title: No association of p53 codon 72 polymorphism with idiopathic recurrent pregnancy loss in Korean population.
abstract: OBJECTIVE
  The balance of apoptosis and proliferation is an important part in the embryonic development during pregnancy. It has been reported that the p53 gene plays a significant role in angiogenesis and placental development, namely in reproduction and is suggested as a potential mediator of pregnancy. This study was performed to investigate whether the genetic polymorphism of the p53 gene is associated with idiopathic recurrent pregnancy loss (RPL).
  
  
  METHODS
  We conducted a case-control study in the Korean population. Study subjects consisted of 294 patients with idiopathic RPL and 300 postmenopausal controls. The genotyping for the p53 codon 72 polymorphism was performed using a Taqman assay. Continuous variables were compared using Student's t test and the χ(2) test was used to evaluate differences in the genotype distributions between the RPL and the controls.
  
  
  RESULTS
  There were no significant differences in the genotype distributions or allele frequencies of the p53 codon 72 polymorphism between the RPL and control group. There was also no significant association between the p53 codon 72 polymorphism and RPL risk in both recessive (Pro/Pro vs. Arg-carriers, p=0.314) and dominant model (Pro-carriers vs. Arg/Arg, p=0.383: data not shown).
  
  
  CONCLUSIONS
  The codon 72 polymorphism in the p53 gene did not show any correlation with idiopathic RPL in Korean women, implying that it may not be susceptible allelic variants or be insufficient to cause RPL.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, Dongguk University, Seoul, Republic of Korea.
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea; The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: ymchoi@snu.ac.kr.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.affiliation: The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: Jin Ju
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Min A
authors.initials: MA
authors.lastname: Hong
authors.affiliation: Department of Obstetrics and Gynecology, Konyang University College of Medicine, Daejeon, Republic of Korea.
authors.forename: Sung Ki
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Kwang Moon
authors.initials: KM
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Bundangcheil Women's Hospital, Seongnam, Republic of Korea.
authors.forename: Eun Chan
authors.initials: EC
authors.lastname: Paik
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003062:Codon; D005260:Female; D005787:Gene Frequency; D016158:Genes, p53; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D056910:Republic of Korea; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53
keywords: Codon 72 polymorphism; Recurrent pregnancy loss; p53 tumor suppressor gene