title: Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue.
abstract: Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnaires on fatigue, sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted with subjects experiencing daily fatigue. After a run-in period, subjects were administered oral SVE or a placebo (P) for 8 weeks. A questionnaire regarding fatigue, sleep and physical appearance was conducted at 0, 4, and 8 weeks. Plasma low-density lipoprotein oxidation lag time was measured as an indicator of anti-oxidative capacity. The per-protocol analysis revealed significant improvements in fatigue status at 4 and 8 weeks compared to 0 weeks in both groups (p<0.01), and sleep and physical appearance at 8 weeks compared to 0 weeks only in the SVE group (p<0.01). There were no significant differences observed between the groups. According to the 72-subject subgroup analysis (aged 40 and over), the sleep and physical appearance significantly improved compared to the P group (p<0.05), and fatigue status showed a tendency for improvement compared to the P group. Anti-oxidative capacity in the SVE group significantly increased compared to the P group (p<0.01). No adverse events relating to SVE supplementation were confirmed. These results suggest SVE supplementation could safely alleviate daily fatigue and oxidative stress.
authors.affiliation: Suntory Wellness Ltd.. Daisuke_Takemoto@suntory.co.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takemoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yasutake
authors.forename: Namino
authors.initials: N
authors.lastname: Tomimori
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ono
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
authors.forename: Junichi
authors.initials: J
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D004311:Double-Blind Method; D005221:Fatigue / Q000188:drug therapy*; D005260:Female; D006801:Humans; D017705:Lignans / Q000627:therapeutic use*; D008297:Male; D018384:Oxidative Stress; D031685:Sesamum; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D017705:Lignans; D014810:Vitamin E