title: The cellular immunity and oxidative stress markers in early pregnancy loss.
abstract: OBJECTIVE
  We investigated whether changes in cellular immunity and oxidative stress in pregnancy have any association with spontaneous miscarriage.
  
  
  METHODS
  Circulating adenosine deaminase (ADA) activity as a marker of cellular immunity and malondialdehyde (MDA) and catalase (CAT), glutathione peroxidase (GPx) as markers of T lymphocyte activation and parameters of oxidative stress and antioxidant defense were compared between 40 women with early pregnancy loss and another 40 women with ungoing healthy pregnancy.
  
  
  RESULTS
  Women with miscarriage had higher serum ADA and GPx levels when compared with women with normal pregnancy (p = 0.034 and p < 0.001, respectively). Although serum MDA level was slightly higher in women with miscarriage, the difference was not significant (p = 0.083). CAT levels were alike in both groups.
  
  
  CONCLUSIONS
  We have demonstrated an increased cellular immunity and perhaps a compensated oxidative stress related to increased antioxidant activation in women with early spontaneous pregnancy loss.
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women Health Care, Education and Research Hospital , Ankara , Turkey .
authors.forename: Korkut
authors.initials: K
authors.lastname: Daglar
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women Health Care, Education and Research Hospital , Ankara , Turkey .
authors.forename: Ebru
authors.initials: E
authors.lastname: Biberoglu
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women Health Care, Education and Research Hospital , Ankara , Turkey .
authors.forename: Ayse
authors.initials: A
authors.lastname: Kirbas
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women Health Care, Education and Research Hospital , Ankara , Turkey .
authors.forename: Aylin Onder
authors.initials: AO
authors.lastname: Dirican
authors.affiliation: b Department of Biochemistry , Ankara University Faculty of Medicine , Ankara , Turkey , and.
authors.forename: Metin
authors.initials: M
authors.lastname: Genc
authors.affiliation: b Department of Biochemistry , Ankara University Faculty of Medicine , Ankara , Turkey , and.
authors.forename: Aslihan
authors.initials: A
authors.lastname: Avci
authors.affiliation: c Department of Obstetrics and Gynecology , Gazi University Medical School , Ankara , Turkey.
authors.forename: Kutay
authors.initials: K
authors.lastname: Biberoglu
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood* / Q000276:immunology; D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D000243:Adenosine Deaminase
keywords: Adenosine deaminase; catalase; glutathione peroxidase; malondialdehyde; miscarriage; spontaneous abortion