title: Pancreatic regeneration: basic research and gene regulation.
abstract: Pancreatic regeneration (PR) is an interesting phenomenon that could provide clues as to how the control of diabetes mellitus might be achieved. Due to the different regenerative abilities of the pancreas and liver, the molecular mechanism responsible for PR is largely unknown. In this review, we describe five representative murine models of PR and thirteen humoral mitogens that stimulate β-cell proliferation. We also describe pancreatic ontogenesis, including the molecular transcriptional differences between α-cells and β-cells. Furthermore, we review 14 murine models which carry defects in genes related to key transcription factors for pancreatic ontogenesis to gain further insight into pancreatic development.
authors.affiliation: Department of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Okita
authors.affiliation: Department of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan. tmizu@sapmed.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Mizuguchi
authors.affiliation: Department of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
authors.forename: Ota
authors.initials: O
authors.lastname: Shigenori
authors.affiliation: Department of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ishii
authors.affiliation: Department of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Nishidate
authors.affiliation: Department of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ueki
authors.affiliation: Department of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Meguro
authors.affiliation: Department of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Tanimizu
authors.affiliation: Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ichinohe
authors.affiliation: Department of Pathology I, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Torigoe
authors.affiliation: Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kojima
authors.affiliation: Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Mitaka
authors.affiliation: Department of Pathology I, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sato
authors.affiliation: Department of Surgical Pathology II, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
authors.forename: Norimasa
authors.initials: N
authors.lastname: Sawada
authors.affiliation: Department of Surgery, JR Sapporo Hospital, N-3, E-1, Chuo-Ku, Sapporo, Hokkaido, 060-0033, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000235:genetics / Q000502:physiology; D004815:Epidermal Growth Factor / Q000502:physiology*; D005755:Gastrins / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology; D050416:Glucagon-Secreting Cells; D006801:Humans; D054795:Incretins / Q000502:physiology*; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D010179:Pancreas / Q000166:cytology / Q000502:physiology*; D012038:Regeneration / Q000235:genetics* / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D005755:Gastrins; D054795:Incretins; D036341:Intercellular Signaling Peptides and Proteins; D014157:Transcription Factors; D004815:Epidermal Growth Factor
keywords: Gene regulation; Pancreatic regeneration; Transcriptional factors