title: Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis.
abstract: Osteoarthritis (OA) is a chronic, progressive, and irreversible degenerative joint disease. Conventional OA treatments often result in complications such as pain and limited activity. However, transplantation of mesenchymal stem cells (MSCs) has several beneficial effects such as paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. In addition, MSCs can be differentiated into several cell types, including chondrocytes, osteocytes, endothelia, and adipocytes. Thus, transplantation of MSCs is a suggested therapeutic tool for treatment of OA. However, transplanted naïve MSCs can cause problems such as heterogeneous populations including differentiated MSCs and undifferentiated cells. To overcome this problem, new strategies for inducing differentiation of MSCs are needed. One possibility is the application of microRNA (miRNA) and small molecules, which regulate multiple molecular pathways and cellular processes such as differentiation. Here, we provide insight into possible strategies for cartilage regeneration by transplantation of differentiated MSCs to treat OA patients.
authors.affiliation: Catholic Kwandong University International St. Mary's Hospital, Incheon 404-834, Korea. onju1336@gmail.com.
authors.forename: Onju
authors.initials: O
authors.lastname: Ham
authors.affiliation: Department of Integrated Omics for Biomedical Sciences, Yonsei University, 50 Yonsei-ro, Seodamun-gu, Seoul 120-759, Korea. cylee083@gmail.com.
authors.forename: Chang Youn
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Korea. kimran2448@naver.com.
authors.forename: Ran
authors.initials: R
authors.lastname: Kim
authors.affiliation: Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Korea. wlgus3045@nate.com.
authors.forename: Jihyun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. ohskjhmi@gmail.com.
authors.forename: Sekyung
authors.initials: S
authors.lastname: Oh
authors.affiliation: Department of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu 702-701, Korea. vetmedic@knu.ac.kr.
authors.forename: Min Young
authors.initials: MY
authors.lastname: Lee
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul 140-742, Korea. jkim@sookmyung.ac.kr.
authors.forename: Jongmin
authors.initials: J
authors.lastname: Kim
authors.affiliation: Catholic Kwandong University International St. Mary's Hospital, Incheon 404-834, Korea. kchwang@cku.ac.kr.
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Hwang
authors.affiliation: Institute of Catholic Integrative Medicine, Incheon St. Mary's Hospital, the Catholic University of Korea, College of Medicine, Incheon 403-720, Korea. mls1004@catholic.ac.kr.
authors.forename: Lee-So
authors.initials: LS
authors.lastname: Maeng
authors.affiliation: Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Korea. wchang1975@pusan.ac.kr.
authors.forename: Woochul
authors.initials: W
authors.lastname: Chang
mesh_terms: D000818:Animals; D020219:Chondrogenesis; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics; D010003:Osteoarthritis / Q000628:therapy*
chemical_list: D035683:MicroRNAs
keywords: differentiation; mesenchymal stem cells; microRNA; osteoarthritis; small molecule