title: Stachybisbins A and B, the first cases of seco-bisabosquals from Stachybotrys bisbyi.
abstract: Stachybisbins A (1) and B (2), two new meroterpenoids with unprecedented seco-bisabosqual skeleton, together with three biogenetically related metabolites (3-5), were isolated from a wetland fungal strain of Stachybotrys bisbyi. The structures of the new compounds were determined by spectroscopic analyses, modified Mosher's method, and quantum chemical CD method. The cytotoxic activities of all compounds were tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines.
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Bao
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Wu
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tyaoxs@jnu.edu.cn.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tghao@jnu.edu.cn.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D013191:Stachybotrys / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D001547:Benzaldehydes; C000603094:LL-Z1272beta; D012717:Sesquiterpenes; D013729:Terpenes
keywords: Cytotoxic activities; Hypocreales; Meroterpenoid; Seco-bisabosqual; Stachybotrys bisbyi