title: Tadalafil therapy for erectile dysfunction following prostatectomy.
abstract: Erectile dysfunction is a major complication affecting the quality of life of patients and partners after radical prostatectomy. Evolving evidence suggests that early penile rehabilitation may provide better erectile function after surgery. Phosphodiesterase type 5 (PDE-5) inhibitors are routinely considered a first-line treatment option in most algorithms for penile rehabilitation owing to their efficacy, ease of use, wide availability and minimal morbidity. Tadalafil is a long-acting, potent PDE-5 inhibitor for erectile dysfunction, with demonstrated effect in animal studies at preserving penile smooth muscle content and prevention of fibrosis of cavernosal tissue. This article evaluates the existing literature on tadalafil and critically analyzes its impact on erectile function following radical prostatectomy.
authors.affiliation: Department of Urology, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Ateş
authors.initials: A
authors.lastname: Kadıoğlu
authors.affiliation: Department of Urology, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Mazhar
authors.initials: M
authors.lastname: Ortaç
authors.affiliation: Department of Urology, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Dinçer
authors.affiliation: University of Western Ontario, 268 Grosvenor St, London, Ontario, Canada N6A4V2.
authors.forename: Gerald
authors.initials: G
authors.lastname: Brock
keywords: erectile dysfunction; penile rehabilitation; radical prostatectomy; tadalafil