title: Peritumoral infiltrate in the prognosis of epidermoid carcinoma of the oral cavity.
abstract: BACKGROUND
  Patients with squamous cell carcinoma of the oral cavity present deficits in their cellular immunity that contribute to neoplastic growth. Thus, the inflammatory activity, such as the immunological response to the tumor, can be used as a prognostic factor.
  
  
  OBJECTIVE
  To evaluate the correlation between peritumoral inflammation and clinical characteristics of the patients, survival, and the disease-free interval.
  
  
  METHODS
  The study sample consisted of a retrospective hospital-based cohort of patients undergoing surgery for resection of oral cavity tumor. The inflammatory infiltrate on the slides was evaluated semi-quantitatively, and were divided into minor and major inflammatory processes.
  
  
  RESULTS
  This study included 57 tumor samples, with infiltration of lymphocytes, plasma cells, and histiocytes. The log-rank test showed no significance for the survival curves and recurrence of the "minor inflammatory" and "major inflammatory" processes, with p=0.14 and p=0.24, respectively. A direct association between age and inflammation (p=0.04) was observed, as well as an indirect association between the degree of tumor differentiation and inflammation (p=0.01).
  
  
  CONCLUSIONS
  Although associated with histological differentiation, the peritumoral inflammatory process cannot be considered a prognostic factor in squamous cell carcinoma of the oral cavity, as it is not related to survival and disease-free interval.
authors.affiliation: Faculdade de Medicina de Marília, Marília, SP, Brazil; Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (HCFMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Vivian Regina
authors.initials: VR
authors.lastname: Affonso
authors.affiliation: Faculdade de Medicina de Marília, Marília, SP, Brazil.
authors.forename: José Raphael de Moura Campos
authors.initials: JR
authors.lastname: Montoro
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (HCFMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Luiz Carlos Conti de
authors.initials: LC
authors.lastname: Freitas
authors.affiliation: Department of Pathology, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil; Pathology Service, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (HCFMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Fabiano Pinto
authors.initials: FP
authors.lastname: Saggioro
authors.affiliation: Department of Child Care and Pediatrics, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Luiz de
authors.initials: Ld
authors.lastname: Souza
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (HCFMRP-USP), Ribeirão Preto, SP, Brazil. Electronic address: rcmmamed@fmrp.usp.br.
authors.forename: Rui Celso Martins
authors.initials: RC
authors.lastname: Mamede
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies
keywords: Carcinoma de células escamosas; Mouth neoplasms; Neoplasias bucais; Prognosis; Prognóstico; Sobrevida; Squamous cell carcinoma; Survival