title: Epidermolysis bullosa acquisita in a 17-year-old boy with Crohn's disease.
abstract: Epidermolysis bullosa acquisita is a rare, acquired, autoimmune subepidermal blistering disease of the skin, characterised by blisters and erosions, especially in trauma-prone sites and extensor skin surface, scarring with formation of milia, skin fragility and nail dystrophy. Epidermolysis bullosa acquisita is extremely rare in childhood and it has been reported to be frequently associated with Crohn's disease. Furthermore, autoantibodies against type VII collagen have been found in a large number of patients with Crohn's disease without epidermolysis bullosa acquisita. We report a case of a 17-year-old boy affected by Crohn's disease who presented with milia on infiltrated erythematous plaques over the back of the hands. The diagnosis of epidermolysis bullosa acquisita was confirmed by histopathology, direct and indirect immunofluorescence analysis and ELISA.
authors.affiliation: Unit of Dermatology, University of Padua, Padova, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Russo
authors.affiliation: Unit of Dermatology, University of Padua, Padova, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Ferrazzi
authors.affiliation: Unit of Dermatology, University of Padua, Padova, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Zanetti
authors.affiliation: Unit of Dermatology, University of Padua, Padova, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Alaibac
mesh_terms: D000293:Adolescent; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications*; D003622:Dapsone / Q000627:therapeutic use*; D016107:Epidermolysis Bullosa Acquisita / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012867:Skin / Q000473:pathology*
chemical_list: D000890:Anti-Infective Agents; D003622:Dapsone