title: THE RELATIONSHIP BETWEEN SERUM 25-HYDROXYVITAMIN D AND GLUCOSE HOMEOSTASIS IN OBESE CHILDREN AND ADOLESCENTS IN ZHEJIANG, CHINA.
abstract: OBJECTIVE
  Evidence of the association between vitamin D, insulin resistance, and oral disposition index (oDI) in obese children and adolescents is limited. To fill this research gap, we measured serum 25-hydroxyvitamin D (25[OH]D) levels in obese children and analyzed the relationship between serum 25(OH)D levels and glucose homeostasis.
  
  
  METHODS
  Altogether, 348 obese and 445 nonobese children and adolescents (age, 6 to 16 years) were enrolled in this study. Obese children were divided into 4 subgroups: normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG and IGT (IFG+IGT) according to oral glucose tolerance test results. We measured serum 25(OH)D levels and calculated the homeostasis model assessment (HOMA) of insulin resistance (IR), the whole-body insulin sensitivity index (WBISI), and the disposition index.
  
  
  RESULTS
  The levels of 25(OH)D in the obese group were significantly lower than in the nonobese group; serum 25(OH)D level in the NGT subgroup was higher than those of the other 3 subgroups, and it was significantly inversely correlated with logHOMA-IR (r = -0.090; P = .045) and positively correlated with logWBISI and logHOMA-oDI (r = 0.091, P = .049; and r = 0.108, P = .046, respectively). Obese patients with vitamin D deficiency thus have a significantly higher risk of disturbances in glucose metabolism.
  
  
  CONCLUSIONS
  25(OH)D deficiency or insufficiency is quite common in obese children and adolescents in Zhejiang, China. Obese patients with 25(OH)D deficiency (<30 nmol/L) are shown to be at higher risk for abnormal glucose metabolism.
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.forename: You-Jun
authors.initials: YJ
authors.lastname: Jiang
authors.forename: Jun-fen
authors.initials: JF
authors.lastname: Fu
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Liang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhu
authors.forename: Li-Fei
authors.initials: LF
authors.lastname: Hu
authors.forename: Guan-Pin
authors.initials: GP
authors.lastname: Dong
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D008297:Male; D063766:Pediatric Obesity / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism; D012621:Seasons; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D014807:Vitamin D; C104450:25-hydroxyvitamin D