title: Self-oocyte activation and parthenogenesis: an unusual outcome of a misconducted IVF cycle.
abstract: A rare cause of infertility is the lack of fertilisation with the spontaneous activation of oocytes, leading to parthenogenesis. We present such a case. The patient was a G1P0 38-year-old woman of African ethnicity, who requested an in vitro fertilisation (IVF) with donor sperm. She received a stimulation protocol of 75 IU of FSH/LH from day 3 of the cycle, which she interrupted after 2 d, and restarted with the same dosage for another 3 d from day 7, plus one administration of GnRH antagonist in day 10 of the cycle. With a follicle reaching 19 mm on day 11, estradiol of 325 ng/ml, ovulation was induced with hMG 5000 UI, and oocyte pick-up performed at 30 h. One oocyte was retrieved, and good-quality sperms were added to the insemination procedure. No fecundation occurred at 20 h, with the extruded oocyte separated from the granulosa wall. At 40 h and 64 h the aspect was of three cells, one cell with one nucleus, the others with high granulation and no visible nuclei. This case shows an unusual self-activation oocyte in a poorly managed IVF cycle. The patient will be further evaluated, to decide if a better managed stimulation protocol would prevent recurrence.
authors.affiliation: a Department of Obstetrics and Gynecology , University of Medicine and Pharmacy Gr.T.Popa , Iasi , Romania .
authors.forename: Razvan
authors.initials: R
authors.lastname: Socolov
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebner
authors.forename: Vlad
authors.initials: V
authors.lastname: Gorduza
authors.forename: Violeta
authors.initials: V
authors.lastname: Martiniuc
authors.forename: Stefano
authors.initials: S
authors.lastname: Angioni
authors.forename: Demetra
authors.initials: D
authors.lastname: Socolov
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009865:Oocytes; D010062:Ovulation Induction; D010312:Parthenogenesis / Q000502:physiology*; D017211:Treatment Failure
keywords: IVF failure; Incorrect hormonal treatment; oocyte self-activation; parthenogenesis