title: Prognostic value of serum IL-17 and VEGF levels in small cell lung cancer.
abstract: OBJECTIVE
  To explore the prognostic value of serum interleukin-17 (IL-17) and vascular endothelial growth factor (VEGF) levels in patients with small cell lung cancer (SCLC).
  
  
  METHODS
  IL-17 and VEGF levels were determined by a commercially available ELISA method.
  
  
  RESULTS
  Serum IL-17 and VEGF levels were higher in the SCLC group than the control group (p&lt;0.001 and p&lt;0.0001, respectively). In addition, there was a significant correlation between IL-17 and VEGF. The level of IL-17 showed significant correlations with tumor stage and tumor metastasis, while serum VEGF levels were significantly associated only with tumor metastasis. Univariate and multivariate analysis indicated that an elevated IL-17 level was an independent prognostic factor for shorter overall survival in SCLC.
  
  
  CONCLUSIONS
  IL-17 may play an important role in tumor dissemination in SCLC patients and measurement of IL-17 could have useful prognostic value for worse overall survival in patients with SCLC.
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Putian University, Putian, Fujian - China.
authors.forename: Qunying
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Thoracic Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai - China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xue
authors.affiliation: Cancer Center, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing - China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.affiliation: Cancer Center, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing - China.|International Joint Cancer Institute, The Second Military Medical University, Shanghai - China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Putian University, Putian, Fujian - China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Putian University, Putian, Fujian - China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Lin
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Putian University, Putian, Fujian - China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Cancer Center, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing - China.|International Joint Cancer Institute, The Second Military Medical University, Shanghai - China.
authors.forename: Kexing
authors.initials: K
authors.lastname: Fan
authors.affiliation: Cancer Center, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing - China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Gu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D055752:Small Cell Lung Carcinoma / Q000097:blood* / Q000401:mortality / Q000556:secondary; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D020381:Interleukin-17; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A