title: Thoracic non-osseous lesions in cancer patients detected in low-dose CT images acquired as part of skeletal SPECT/CT examinations.
abstract: OBJECTIVE
  Hybrid single-photon emission tomographic (SPECT) and X-ray computed tomography (CT) systems are increasingly used in oncologic imaging. With SPECT/CT not only the thoracic spine but also the surrounding soft tissue needs to be evaluated for pathological findings. The purpose of this study was to assess the prevalence of non-osseous findings detectable on low-dose CT datasets from patients studied by thoracic 99mTc-dicarboxypropane diphosphonate (DPD)-SPECT/CT.
  
  
  METHODS
  119 consecutive oncologic patients (81 breast cancer, 38 with other cancer) who underwent DPD-SPECT CT of the thoracic region were included in this study. Non-osseous findings on CT were classified as either probably benign or suspicious. Suspicious findings were correlated with retrievable previous imaging and if performed with follow up imaging (MRI, CT with contrast medium, Ultrasound) or biopsy results.
  
  
  RESULTS
  In 80/119 (67%) patients no imaging was performed before SPECT/CT. Only 7/119 subjects (6%) had no other lesions than bone lesions. In 101/119 (85%) patients lesions found on SPECT/CT images were rated as benign and in 65/119 (55%) patients as suspicious. In 8/119 (7%) patients with previously unknown suspicious lesions on SPECT/CT images suspicious findings were confirmed by biopsy.
  
  
  CONCLUSIONS
  7% of patients referred to SPECT/CT of the thoracic spine for staging of malignant disease had previously unknown suspicious non-osseous lesions detectable on the low-dose CT images which were confirmed by biopsy. This could be especially relevant for cancer entities like breast and prostate, in which no thorax-CT is routinely intended for staging.
authors.affiliation: Wolfgang Wuest, MD, Radiological Institute, Friedrich-Alexander-University-Erlangen-Nuremberg, Maximiliansplatz 1, 91054 Erlangen, Germany, Tel. +49/(0)91 31/854 55 07, Fax +49/(0)91 31/853 60 68, E-mail: wolfgang.wuest@uk-erlangen.de.
authors.forename: W
authors.initials: W
authors.lastname: Wuest
authors.forename: M
authors.initials: M
authors.lastname: Lell
authors.forename: M S
authors.initials: MS
authors.lastname: May
authors.forename: M
authors.initials: M
authors.lastname: Saake
authors.forename: T
authors.initials: T
authors.lastname: Kuwert
authors.forename: M
authors.initials: M
authors.lastname: Uder
authors.forename: R
authors.initials: R
authors.lastname: Linke
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000175:diagnosis*; D002648:Child; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000175:diagnosis; D013899:Thoracic Neoplasms / Q000175:diagnosis*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
keywords: Non-osseous suspicious lesions; incidental findings; low-dose thorax CT images; skeletal SPECT/CT