title: TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis.
abstract: TREM-1 and TREM-2 molecules are members of the TREM transmembrane glycoproteins. In our previous study we identified increased expressions of TREM-1 and TREM-2 receptors in pulmonary sarcoidosis (PS). Only a few studies concerning the association between vitamin D and TREM receptor expression can be found. The aim of our current study was to determine the association between the levels of an inactive form of 25(OH)D vitamin and TREM-1 and TREM-2 receptor expressions. We have detected low levels of 25(OH)D vitamin in 79% of PS patients. Only 21% of patients had normal serum level of 25(OH)D vitamin with values clustered within the low-normal range. The most striking findings were the increased TREM-2 expressions on myeloid cells surfaces in BALF of PS patients with normal 25(OH)D vitamin serum levels compared with those with its decreased levels. The total number of TREM-2 positive cells was 5.7 times higher and the percentage of TREM-2 positive cells was also significantly increased in BALF of PS patients with normal compared to PS patients with low 25(OH)D vitamin serum levels. A significant correlation between total TREM-2 expression and vitamin D levels has been detected too. However, we have not detected similar differences in TREM-1expression and 25(OH)D vitamin serum levels.
authors.affiliation: Institute of Immunology, Faculty of Medicine, Comenius University, 81372 Bratislava, Slovakia.
authors.forename: Maria
authors.initials: M
authors.lastname: Bucova
authors.affiliation: Institute of Immunology, Faculty of Medicine, Comenius University, 81372 Bratislava, Slovakia.
authors.forename: Magda
authors.initials: M
authors.lastname: Suchankova
authors.affiliation: Medirex Ltd., 82016 Bratislava, Slovakia.
authors.forename: Elena
authors.initials: E
authors.lastname: Tibenska
authors.affiliation: Department of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, Slovakia.
authors.forename: Eva
authors.initials: E
authors.lastname: Tedlova
authors.affiliation: Department of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, Slovakia.
authors.forename: Juraj
authors.initials: J
authors.lastname: Demian
authors.affiliation: Department of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, Slovakia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Majer
authors.affiliation: Department of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, Slovakia.
authors.forename: Helena
authors.initials: H
authors.lastname: Novosadova
authors.affiliation: 1st Department of Otorhinolaryngology, Faculty of Medicine, Comenius University, 85107 Bratislava, Slovakia.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Tedla
mesh_terms: D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000502:physiology; D011971:Receptors, Immunologic / Q000032:analysis* / Q000502:physiology; D017565:Sarcoidosis, Pulmonary / Q000378:metabolism*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; C498715:TREM2 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014807:Vitamin D; C104450:25-hydroxyvitamin D