title: Population-based study for human papillomavirus (HPV) infection in young women in Japan: A multicenter study by the Japanese human papillomavirus disease education research survey group (J-HERS).
abstract: A multi-center study was conducted to examine 6,628 eligible Japanese women aged from 16 to 50 years for uterine cervical abnormality and HPV infection with a liquid based-cytology test and a novel HPV test using the PCR-SSOP-Luminex(®) method identifying 31 HPV genotypes. In 3,047 normal subjects, the overall prevalence across all HPV types was 25%, while that of the common 13 high-risk (Common-13HR) types (HPV-16, 18. 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) was 17%, and that of the definite high-risk (Definite-HR) types (HPV-16, 18. 31, 33, 35, 45, 52, and 58) was 12%. For Definite-HR, HPV-52, 16, and 58 were the most common, HPV-31 was relatively common, and HPV-18 was less common, while HPV-33, 35, and 45 were rare. Seven Definite-HR excluding HPV-45 and seven Possible-HR (HPV-39, 51, 56, 66, 68, 70, and 82) HPV types were identified as a single type infection in patients with high-grade squamous intraepithelial lesion (HSIL) or worse. The Common-13HR types were detected in 89% of subjects with HSIL, whereas either Definite-HR or Possible-HR types were detected in 95% of HSIL. These 1420 HPV types appear to be involved with HSIL or worse in Japan. The prevalences of multiple-type HPV infections were identified in roughly half of HPV-positive subjects, and decreased significantly with age in normal population and abnormal cytology groups, although the prevalences of single-type infections increased with age in the latter group. Most HPV infections are cleared for some years, while a certain HR-HPV type persists to induce HSIL.
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sasagawa
authors.affiliation: Department of Obstetrics and Gynecology, Tomishiro Central Hospital, Okinawa, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Maehama
authors.affiliation: Chayamachi-Ladies Clinic, Osaka, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Ideta
authors.affiliation: Bunkamura-dori Ladies Clinic, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Irie
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D003584:Cytological Techniques; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008403:Mass Screening; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D017720:Molecular Epidemiology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult
keywords: Japanese women; cervical cancer; epidemiology; liquid-based cytology; mucosal HPV types