title: Phenotype and function of tissue-resident unconventional Foxp3-expressing CD4(+) regulatory T cells.
abstract: It is becoming increasingly clear that regulatory T cells (Treg cells) in specific tissues are important parts of immune system. Tissue-resident Treg cells, which are largely Foxp3-expressing CD4(+) Treg cells, are distinct from one another and conventional Treg cells, and have tissue-specific phenotype and function. They have roles in improving insulin sensitivity in adipose tissue, promoting muscle repair, limiting inflammation in intestine, skin and central nervous system. In this Review, we discuss the current understanding of phenotype and function of tissue-resident Treg cells. Understanding phenotypic and functional diversity in different tissues could provide new insight into Treg cells development and investigation.
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, PR China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, PR China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Meng
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, PR China.
authors.forename: Ailing
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, PR China. Electronic address: firstph@163.com.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D002490:Central Nervous System / Q000166:cytology / Q000276:immunology; D051858:Forkhead Transcription Factors / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000276:immunology; D009132:Muscles / Q000166:cytology / Q000276:immunology; D009928:Organ Specificity / Q000276:immunology; D012867:Skin / Q000166:cytology / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000276:immunology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
keywords: Function; Phenotype; Tissue-resident Treg cells