title: GSTM1 and GSTT1 genes null polymorphisms in kidney cancer susceptibility: evidence based on a meta-analysis.
abstract: BACKGROUND
  Renal cancer is a complex and multifactorial oncourologic disease.
  
  
  OBJECTIVE
  To conduct a meta-analysis in order to investigate the association of GSTM1 and GSTT1 genes null polymorphisms in renal cancer.
  
  
  METHODS
  Case-control studies in humans, published from 1999 to 2013, that investigated the association of GSTM1 and GSTT1 genes null polymorphisms in renal cancer were grouped in order to make of this meta-analysis.
  
  
  RESULTS
  Ten articles were selected on the subject proposed. No associations were found between polymorphisms of GSTM1-null (OR = 1.015, 95% CI = 0.897 to 1.147) and GSTT1-null (OR = 1.081, 95% CI = 0.791 to 1.479) and renal cancer.
  
  
  CONCLUSIONS
  Based on the results obtained, we conclude that the GSTM1 and GSTT1 null polymorphisms are not associated with the risk of developing renal cancer, since they have limited role, if there is any on effective contribution in the development of renal tumors.
authors.affiliation: Pontifícia Universidade Católica de Goiás, Brazil.
authors.forename: Cláudio Nunes
authors.initials: CN
authors.lastname: da Silva
authors.affiliation: Pontifícia Universidade Católica de Goiás, Brazil.
authors.forename: Douglas Nunes
authors.initials: DN
authors.lastname: da Silva
authors.affiliation: Universidade Federal de Goiás, Brazil.
authors.forename: Katarinne Lima
authors.initials: KL
authors.lastname: Moraes
authors.affiliation: Universidade Federal de Goiás, Brazil.
authors.forename: Jacqueline Andréia Bernardes Leão
authors.initials: JA
authors.lastname: Cordeiro
authors.affiliation: Universidade Federal de Goiás, Brazil.
authors.forename: Virginia Visconde
authors.initials: VV
authors.lastname: Brasil
authors.affiliation: Pontifícia Universidade Católica de Goiás, Brazil.
authors.forename: Vera Aparecida
authors.initials: VA
authors.lastname: Saddi
authors.affiliation: Pontifícia Universidade Católica de Goiás, Brazil.
authors.forename: Antonio Márcio Teodoro Cordeiro
authors.initials: AM
authors.lastname: Silva
mesh_terms: D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1