title: Reorganization of Motor Execution Networks During Sub-Acute Phase After Stroke.
abstract: Numerous studies focused on brain reorganization after stroke from aspects of task-related brain activity and resting-state brain networks. However, studies focusing on the longitudinal reorganization of task-state brain networks were scarce. In this study, functional magnetic resonance imaging data were collected from twelve stroke patients during blocked finger-tapping task at four post-stroke time points (less than 10 days, around 2 weeks, 1 month and 3 months), respectively. The dynamic changes and prognostic value of the network parameters (i.e., topological parameters, functional connectivity and nodal parameters) in task-state motor execution networks were thoroughly evaluated. We found that the topological configuration (clustering coefficient and characteristic path length) of task-state motor execution networks underwent significant shift during stroke recovery. Especially, we found the topological configuration of task-state motor execution networks at the early recovery stage were capable of predicting the motor function restoration during sub-acute phase. In addition, we found increasing functional connectivity between ipsilesional cerebellum and motor cortices in task-state motor execution networks. In general, this study demonstrated the reorganization and prognostic value of task-state brain network after stroke, which provides new insights into understanding the brain reorganization and rehabilitation after stroke.
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Wu
authors.forename: Junfeng
authors.initials: J
authors.lastname: Sun
authors.forename: Yi
authors.initials: Y
authors.lastname: Fu
authors.forename: Xinning
authors.initials: X
authors.lastname: Wang
authors.forename: Guo-Yuan
authors.initials: GY
authors.lastname: Yang
authors.forename: Fei
authors.initials: F
authors.lastname: Miao
authors.forename: Shanbao
authors.initials: S
authors.lastname: Tong
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D002531:Cerebellum / Q000503:physiopathology; D005260:Female; D005385:Fingers; D006225:Hand / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology; D009048:Motor Skills / Q000502:physiology; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000503:physiopathology*; D011379:Prognosis; D011597:Psychomotor Performance; D020127:Recovery of Function; D020521:Stroke / Q000503:physiopathology*; D000071939:Stroke Rehabilitation