title: The complex interplay of Depression, Inflammation and Omega-3: state of the art and progresses in research.
abstract: Many epidemiological and preclinical studies have proven the potential benefit and critical role of omega-3 PUFAs in the development and management of depressive disorders. Depression may be the consequence of a complex interplay between cell-mediated-immune activation and inflammation evolving in neuroprogression. Associations between n-3 PUFAs, inflammation, oxidative stress and the risk of depression have been demonstrated and clinical and animal supplementation studies have shown the potential of PUFAs to decrease neurodegeneration and inflammation. Future research should focus on the dynamic interactions between the different cell signaling networks and oxidative and nitrosative stress pathways that cause depression.
authors.affiliation: Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mazza
authors.affiliation: Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Marano
authors.affiliation: Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Traversi
authors.affiliation: Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Di Nicola
authors.affiliation: Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Catalano
authors.affiliation: Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Janiri
mesh_terms: D000818:Animals; D003863:Depression / Q000503:physiopathology*; D003866:Depressive Disorder / Q000188:drug therapy; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology; D012306:Risk
chemical_list: D015525:Fatty Acids, Omega-3
keywords: Depression; Immunity; Inflammation; Omega-3; Oxidative stress; PUFAs