title: Localized juvenile spongiotic gingival hyperplasia possibly originates from the junctional gingival epithelium-an immunohistochemical study.
abstract: OBJECTIVE
  To immunohistochemically evaluate the cytokeratin (CK) pattern of expression in localized juvenile spongiotic gingival hyperplasia (LJSGH) as compared with the gingival epithelium (GE).
  
  
  RESULTS
  Ten cases of LJSGH were semiquantitatively evaluated for the immunohistochemical pattern of CK1/10, CK4, CK8/18, and CK19. GE controls were taken from 10 cases of reactive gingival fibroepithelial hyperplasia. GEs showed mean positivity rates of 80% for both CK1/10 and CK4, and 5% for both CK8/18 and CK19. LJSGHs showed mean positivity rates of 65% for CK19, 60% for CK8/18, 30% for CK4, and 5% for CK1/10. The differences between LJSGHs and GEs were statistically significant (P < 0.01).
  
  
  CONCLUSIONS
  The LJSGH pattern of CK expression is reminiscent of the profile described in the literature for the junctional epithelium (JE). Possibly, JE exteriorized from the gingival sulcus would be more prone to irritation from a variety of sources, resulting in inflammation and hyperplasia, with the subsequent development of LJSGH.
authors.affiliation: Department of Oral Pathology & Oral Medicine, School of Dental Medicine, Tel-Aviv University, Tel Aviv, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Allon
authors.affiliation: Baylor College of Dentistry, Texas A&M University, Dallas, TX, USA.
authors.forename: Kaila M
authors.initials: KM
authors.lastname: Lammert
authors.affiliation: Baylor College of Dentistry, Texas A&M University, Dallas, TX, USA.
authors.forename: Rei
authors.initials: R
authors.lastname: Iwase
authors.affiliation: Baylor College of Dentistry, Texas A&M University, Dallas, TX, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Spears
authors.affiliation: Baylor College of Dentistry, Texas A&M University, Dallas, TX, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Wright
authors.affiliation: Baylor College of Dentistry, Texas A&M University, Dallas, TX, USA.
authors.forename: Aparna
authors.initials: A
authors.lastname: Naidu
mesh_terms: D000293:Adolescent; D002648:Child; D004846:Epithelial Attachment / Q000473:pathology*; D005260:Female; D005881:Gingiva / Q000473:pathology; D005885:Gingival Hyperplasia / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis / Q000096:biosynthesis; D008297:Male
chemical_list: D007633:Keratins
keywords: cytokeratin; gingiva; hyperplasia; junctional epithelium; localized juvenile spongiotic gingival sulcular epithelium