title: Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging.
abstract: We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.
authors.affiliation: Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia. niveen.khashab@kaust.edu.sa.
authors.forename: Y
authors.initials: Y
authors.lastname: Fatieiev
authors.forename: J G
authors.initials: JG
authors.lastname: Croissant
authors.forename: K
authors.initials: K
authors.lastname: Julfakyan
authors.forename: L
authors.initials: L
authors.lastname: Deng
authors.forename: D H
authors.initials: DH
authors.lastname: Anjum
authors.forename: A
authors.initials: A
authors.lastname: Gurinov
authors.forename: N M
authors.initials: NM
authors.lastname: Khashab
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D053761:Nanocomposites / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D017646:Organosilicon Compounds