title: Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis.
abstract: β-transducin repeat-containing E3 ubiquitin protein ligase (β-TrCP) targets a number of substrates essential for specific aspects of tumorigenesis. In addition, β-TrCP regulates various important signaling pathways. As β-TrCP is involved in regulating the ubiquitination and degradation of multiple oncogenes and tumor suppressors, the function of β-TrCP varies between cancer types. At present, the association between β-TrCP expression and clinicopathological factors in glioma is unknown. Therefore, the current study used western blotting and immunohistochemistry to investigate the expression of β-TrCP protein in glioma tissue specimens. It was identified that β-TrCP protein expression levels were significantly lower in glioma compared with non-tumorous human brain tissues. Furthermore, the higher the grade of glioma, the lower the level of β-TrCP expression. Kaplan-Meier analysis demonstrated that patients with low β-TrCP expression experienced significantly worse overall survival compared with patients with high β-TrCP expression. The results indicate that downregulation of β-TrCP may be associated with poor survival in patients with glioma. Together, the current data indicates that β-TrCP may be applied as a useful indicator of glioma prognosis and may serve as an anticancer therapeutic target for glioma, however further investigation is required.
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Shao
authors.initials: S
authors.lastname: Xie
authors.affiliation: Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Jin-Xia
authors.initials: JX
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China ; Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Ru-Tong
authors.initials: RT
authors.lastname: Yu
keywords: glioma; immunohistochemistry; prognosis; western blotting; β-transducin repeat-containing E3 ubiquitin protein ligase expression