title: Time-limited hydrotubation combined with clomiphene citrate treatment for unexplained infertility.
abstract: OBJECTIVE
  To evaluate time-limited hydrotubation combined with clomiphene citrate as treatment for unexplained infertility.
  
  
  METHODS
  In this unblinded, randomized controlled trial of patients who had unexplained infertility, 40 patients were treated with time-limited hydrotubation (saline, 20 ml; flushed within 20 to 30 seconds) and clomphene citrate (total, 70 cycles) and 40 patients were treated with clomiphene citrate alone (total, 74 cycles). All women underwent an ovulation induction protocol with clomiphene citrate (100 mg/d orally for five days, from day 3 to day 7 of the cycle). Hydrotubation was performed after detection of the dominant follicle.
  
  
  RESULTS
  There were 15 pregnancies in the 80 patients (19%) (total, 144 stimulated cycles; 10% pregnancies per cycle). The frequency of clinical pregnancy per cycle was significantly greater in patients who were treated with hydrotubation and clomiphene citrate (nine pregnancies per cycle [13%]) than those treated with clomiphene citrate alone (two pregnancies per cycle [3%]; odds ratio, 5.3; 95% confidence interval, 1.1 to 25.5; p ≤ 0.05). The frequency of pregnancy per patient (total, clinical, or chemical) was similar for the two treatment groups. The frequency of live birth or abortion per cycle or patient was similar between the two treatment groups.
  
  
  CONCLUSIONS
  Time-limited hydrotubation and clomiphene citrate may increase the frequency of clinical pregnancy per cycle in women who have unexplained infertility.
authors.forename: O E
authors.initials: OE
authors.lastname: Yapca
authors.forename: I B
authors.initials: IB
authors.lastname: Delibas
authors.forename: I
authors.initials: I
authors.lastname: Karaca
authors.forename: Y
authors.initials: Y
authors.lastname: Kumtepe
authors.forename: S
authors.initials: S
authors.lastname: Kadanali
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005187:Fallopian Tubes; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D007246:Infertility / Q000628:therapy; D007247:Infertility, Female / Q000628:therapy*; D050498:Live Birth; D006080:Ovarian Follicle; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D007507:Therapeutic Irrigation / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene