title: A Systematic Review and Meta-Analysis of Three Gene Variants Association with Risk of Prostate Cancer: An Update.
abstract: OBJECTIVE
  Prostate cancer (PCa) is one of the most commonly diagnosed male malignancies. Nu­merous studies have investigated the role of genetic variants in PCa risk. However, the results re­main unclear. The purpose of this study was to evaluate the relationship between single-nucleo­tide polymorphism (SNP) rs2228001 in xeroderma pigmentosum group C (XPC), SNP rs4073 in interleukin 8 (IL8), and SNP rs2279744 in mouse double minute 2 (MDM2) homolog gene with PCa susceptibility.
  
  
  METHODS
  Electronic database of PubMed, Medline, and Embase were searched for eligible articles published between January 2000 and April 2014. The odd ra­tio (OR) with its 95% confidence interval (CI) were calculated to estimate the strength of association.
  
  
  RESULTS
  A total 18 case-control studies, including 5725 PCa cases and 5900 healthy controls, were screened out. Six studies were eligible for each SNP. For XPC 939A/C polymorphism, no significant association was found with PCa risk in the whole population (P > .05). No relationship in subgroup analysis was found by ethnicity. For IL8 -251T/A variant, the A allele was not related with PCa risk in any genetic models when compared with those individuals without A allele. For MDM2 -309T/G mutation, the G allele was not as­sociated with the increased risk of PCa in total population and subgroup analysis by ethnicity as well.
  
  
  CONCLUSIONS
  Our study demonstrated that all these three genetic polymorphisms were not associated with an in­creased risk of developing PCa, which might also provide an insight into the future research. Further large-scale studies with concerning the gene-gene and gene-environment interactions are needed to elucidate final conclusion.
authors.affiliation: Department of Urology, Affiliated Hospital of Huzhou Teachers› College, The First People›s Hospital of Hu zhou, Hu zhou, 313000, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Urology, Affiliated Hospital of Huzhou Teachers› College, The First People›s Hospital of Hu zhou, Hu zhou, 313000, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhong
authors.affiliation: Department of Urology, Affiliated Hospital of Huzhou Teachers› College, The First People›s Hospital of Hu zhou, Hu zhou, 313000, China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Gao
authors.affiliation: Department of Urology, Affiliated Hospital of Huzhou Teachers› College, The First People›s Hospital of Hu zhou, Hu zhou, 313000, China.
authors.forename: Jian-Er
authors.initials: JE
authors.lastname: Tang
authors.affiliation: Department of Urology, Affiliated Hospital of Huzhou Teachers› College, The First People›s Hospital of Huzhou, Huzhou, 313000, China. rongjiangwang_r@163.com.
authors.forename: Rongjiang
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D004273:DNA, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D051759:Xeroderma Pigmentosum Group D Protein / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D051759:Xeroderma Pigmentosum Group D Protein