title: A new 3-alkylpyridine alkaloid from the marine sponge Haliclona sp. and its cytotoxic activity.
abstract: A new alkaloid, 3-dodecyl pyridine containing a terminal cyano group (1), was isolated from the methanol extract of an Indonesia marine sponge Haliclona sp. Its chemical structure was determined by a combination of spectroscopic methods, including 1D and 2D NMR. Bioassay results indicated that compound 1 had moderate cytotoxity against tumour cell lines A549, MCF-7 and Hela with IC50 values of 41.8, 48.4 and 33.2 μM, respectively.
authors.affiliation: a School of Pharmaceutical Sciences, Zhejiang University of Technology , Hangzhou 310014 , P.R. China.|b Department of Chemistry and Biochemistry , University of California , Santa Cruz , CA 95064 , USA.
authors.forename: Huawei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: b Department of Chemistry and Biochemistry , University of California , Santa Cruz , CA 95064 , USA.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Loveridge
authors.affiliation: b Department of Chemistry and Biochemistry , University of California , Santa Cruz , CA 95064 , USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Tenney
authors.affiliation: b Department of Chemistry and Biochemistry , University of California , Santa Cruz , CA 95064 , USA.
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D047129:Haliclona / Q000737:chemistry*; D006801:Humans; D007214:Indonesia; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D011725:Pyridines / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D011725:Pyridines; C023666:pyridine
keywords: 3-alkylpyridine; Haliclona sp.; alkaloid; cytotoxicity