title: ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer.
abstract: Immunoglobulin-like transcript (ILT) 4 is critical for the inhibitory function of certain immune cells. We previously demonstrated that ILT4 is over-expressed in human non-small cell lung cancer (NSCLC) cells and is involved in tumour evasion via an unknown mechanism. In this report, we demonstrate that ILT4 increases the expression of the co-inhibitory molecule B7-H3 through PI3K/AKT/mTOR signalling. In primary human NSCLC tissues, a significant positive relationship is observed between ILT4 and B7-H3 expression. ILT4/B7-H3 co-expression is significantly associated with a reduction in T infiltrating lymphoid cells and lower overall survival. In summary, ILT4 increases B7-H3 expression and ILT4/B7-H3 co-expression may be involved in NSCLC progression.
authors.affiliation: Department of Oncology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Pei
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Geratology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Oncology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Chuanyong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Oncology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oncology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Wenli
authors.initials: W
authors.lastname: Lin
authors.affiliation: Department of Oncology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Aiqin
authors.initials: A
authors.lastname: Gao
authors.affiliation: Department of Oncology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Oncology, Jinan Central Hospital, Shandong University, 105 Jie Fang Road, Jinan, Shandong 250013, PR China. Electronic address: 13370582181@163.com.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Sun
mesh_terms: D060887:B7 Antigens / Q000235:genetics* / Q000378:metabolism; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics* / Q000378:metabolism; D034622:RNA Interference; D011971:Receptors, Immunologic / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000235:genetics; D058570:TOR Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism
chemical_list: D060887:B7 Antigens; D008562:Membrane Glycoproteins; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D011971:Receptors, Immunologic; D058570:TOR Serine-Threonine Kinases; C423237:CD276 protein, human; C491341:LILRB2 protein, human; C546842:MTOR protein, human
keywords: B7-H3; ILT4; Non-small cell lung cancer; PI3K/AKT/mTOR signalling