title: COMPARISON OF VITAMIN D REPLACEMENT STRATEGIES WITH HIGH-DOSE INTRAMUSCULAR OR ORAL CHOLECALCIFEROL: A PROSPECTIVE INTERVENTION STUDY.
abstract: OBJECTIVE
  To ascertain the frequency of correction of vitamin D deficiency (VDD) with single or multiple doses of oral (p.o.) and intramuscular (i.m.) administration of 2 high-dose preparations of vitamin D3 (VD3).
  
  
  METHODS
  This was a prospective intervention study conducted in an ambulatory care setting. One hundred participants with VDD (25-hydroxy vitamin D [25-OHD] <20 ng/mL) were randomized to receive a dose of 600,000 or 200,000 IU of VD3 via a p.o. or i.m. route. The main outcome measure was serum 25-OHD levels at 2, 4, and 6 months after the intervention. The same dose was repeated in participants if 25-OHD remained <30 ng/mL at 2 and 4 months.
  
  
  RESULTS
  At 2 months, VDD was corrected in 93.8% of participants in Group 1 (600,000 IU i.m.); 83.3% in Group 2 (600,000 IU p.o.), 87.5% in Group 3 (200,000 IU i.m.), and 70.6% in Group 4 (200,000 IU p.o.). The mean changes from baseline in vitamin D levels at 2 months were 29.6 ± 13.7, 19.8 ± 12.3, 18.3 ± 10.6, and 13.7 ± 7.8 ng/mL in Groups 1, 2, 3, and 4, respectively. The mean levels remained significantly higher from baseline in all groups at all time points during the 6 months of observation. The mean 25-OHD level achieved in Group 1 was significantly higher than all other groups at 6 months.
  
  
  CONCLUSIONS
  Two months after the intervention, VDD was corrected in more than 70% of participants with a single dose of either 600,000 or 200,000 IU given p.o. or i.m.
authors.forename: Muhammad Qamar
authors.initials: MQ
authors.lastname: Masood
authors.forename: Aysha
authors.initials: A
authors.lastname: Khan
authors.forename: Safia
authors.initials: S
authors.lastname: Awan
authors.forename: Farhan
authors.initials: F
authors.lastname: Dar
authors.forename: Sabahat
authors.initials: S
authors.lastname: Naz
authors.forename: Ghazala
authors.initials: G
authors.lastname: Naureen
authors.forename: Shakil
authors.initials: S
authors.lastname: Saghir
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D016896:Treatment Outcome; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D002762:Cholecalciferol