title: Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis.
abstract: OBJECTIVE
  To investigate the efficacy and safety profile of pancreatic duct (PD) stent placement for prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).
  
  
  METHODS
  We performed a search of MEDLINE, EMBASE, and Cochrane Library to identify randomized controlled clinical trials of prophylactic PD stent placement after ERCP. RevMan 5 software provided by Cochrane was used for the heterogeneity and efficacy analyses, and a meta-analysis was performed for the data that showed homogeneity. Categorical data are presented as relative risks and 95% confidence intervals (CIs), and measurement data are presented as weighted mean differences and 95%CIs.
  
  
  RESULTS
  The incidence rates of severe pancreatitis, operation failure, complications and patient pain severity were analyzed. Data on pancreatitis incidence were reported in 14 of 15 trials. There was no significant heterogeneity between the trials (I(2) = 0%, P = 0.93). In the stent group, 49 of the 1233 patients suffered from PEP, compared to 133 of the 1277 patients in the no-stent group. The results of this meta-analysis indicate that it may be possible to prevent PEP by placing a PD stent.
  
  
  CONCLUSIONS
  PD stent placement can reduce postoperative hyperamylasemia and might be an effective and safe option to prevent PEP if the operation indications are well controlled.
authors.affiliation: Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.
authors.forename: Jin-He
authors.initials: JH
authors.lastname: Fan
authors.affiliation: Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.
authors.forename: Jun-Bo
authors.initials: JB
authors.lastname: Qian
authors.affiliation: Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.
authors.forename: Ya-Min
authors.initials: YM
authors.lastname: Wang
authors.affiliation: Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Shi
authors.affiliation: Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.
authors.forename: Cheng-Jin
authors.initials: CJ
authors.lastname: Zhao
mesh_terms: D016009:Chi-Square Distribution; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects* / Q000295:instrumentation*; D006801:Humans; D015994:Incidence; D016017:Odds Ratio; D010195:Pancreatitis / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D011474:Prosthesis Design; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome
keywords: Endoscopic retrograde cholangiopancreatography; Pancreatic stent placement; Pancreatitis; Post-endoscopic retrograde cholangiopancreatography pancreatitis