title: Osteoporosis in Children with Chronic Disease.
abstract: Serious illness in children and its therapy can cause osteoporosis, manifesting as vertebral and nonvertebral fractures, pain, skeletal deformity and temporary or even permanent loss of ambulation. In contrast to adults, skeletal growth in children offers tremendous potential to recover bone mineral density and to reshape fractured vertebral bodies, even without bone-targeted therapy, provided that bone health threats are transient and residual growth is sufficient. Here, we outline the principles of bone strength development and the risk factors for osteoporosis due to various paediatric systemic illnesses. We also explain why the approach to the diagnosis and monitoring of childhood osteoporosis has moved away from a bone density-centric focus to a more functional assessment. Finally, we discuss the best candidates for and current approaches to the treatment of osteoporosis in children.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Högler
authors.forename: Leanne
authors.initials: L
authors.lastname: Ward
mesh_terms: D000856:Anorexia Nervosa / Q000150:complications*; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001846:Bone Development; D001842:Bone and Bones; D002648:Child; D002908:Chronic Disease; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D007249:Inflammation / Q000150:complications; D007938:Leukemia / Q000150:complications*; D009468:Neuromuscular Diseases / Q000150:complications*; D010024:Osteoporosis / Q000209:etiology* / Q000517:prevention & control; D058866:Osteoporotic Fractures / Q000209:etiology* / Q000517:prevention & control; D012216:Rheumatic Diseases / Q000150:complications; D012307:Risk Factors; D055502:Secondary Prevention; D013131:Spine; D019737:Transplants
chemical_list: D050071:Bone Density Conservation Agents; D005938:Glucocorticoids