title: Velucarpins A-C, three new pterocarpans and their cytotoxicity from the roots of Dalbergia velutina.
abstract: Three new pterocarpans, named velucarpins A-C (1-3), along with three known pterocarpans (4-6) were isolated from the roots of Dalbergia velutina. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 3 and 5 showed good cytotoxicity against KB and HeLa cells with IC50 values of 8.22, 8.09 μM and 5.99, 8.69 μM, respectively.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Sutin
authors.initials: S
authors.lastname: Kaennakam
authors.affiliation: Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siripong
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: Santi.Ti@chula.ac.th.
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-pyang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D035782:Dalbergia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D036343:Pterocarpans / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036343:Pterocarpans; C000603095:velucarpin C
keywords: Cytotoxicity; Dalbergia velutina; Leguminosae; Pterocarpans; Velucarpins A–C