title: Digging for Buried Amino Acids Unearths New Protein Quality Control Treasure.
abstract: Proteins rely on three-dimensional structure for function, yet many proteins are marginally stable and prone to misfolding. In this issue of Structure, Brock et al. (2015) present a novel computational modeling method to gain insights into protein stability and misfolding.
authors.affiliation: Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Ramon D
authors.initials: RD
authors.lastname: Jones
authors.affiliation: Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: gardnerr@uw.edu.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Gardner
mesh_terms: D006801:Humans; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000737:chemistry*
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein