title: Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins.
abstract: Recent functional studies on chondroitin sulfate-dermatan sulfate (CS-DS) demonstrated its indispensable roles in various biological events including brain development and cancer. CS-DS proteoglycans exert their physiological activity through interactions with specific proteins including growth factors, cell surface receptors, and matrix proteins. The characterization of these interactions is essential for regulating the biological functions of CS-DS proteoglycans. Although amino acid sequences on the bioactive proteins required for these interactions have already been elucidated, the specific saccharide sequences involved in the binding of CS-DS to target proteins have not yet been sufficiently identified. In this review, recent findings are described on the interaction between CS-DS and some proteins which are especially involved in the central nervous system and cancer development/metastasis.
authors.affiliation: Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Mizumoto
authors.affiliation: Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Sapporo, Japan. Electronic address: k-sugar@sci.hokudai.ac.jp.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sugahara
mesh_terms: D000818:Animals; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000378:metabolism; D003871:Dermatan Sulfate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry* / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000378:metabolism; D060449:Wnt Signaling Pathway
chemical_list: D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; D000067759:Receptor for Advanced Glycation End Products; D011956:Receptors, Cell Surface; C069524:dermatan sulfate chondroitin sulfate; D003871:Dermatan Sulfate; D002809:Chondroitin Sulfates