title: Thyroglossal duct cyst carcinoma: diagnostic and management considerations in a 15-year-old with a large submental mass.
abstract: A 15-year old boy presented with a 2-year history of a painless slowly enlarging submental neck mass. Head and neck imaging showed a multicystic mass with a central solid component that was closely applied to the hyoid bone. Core needle biopsy under general anaesthesia revealed a papillary thyroid neoplasm. The mass was resected and frozen section histology confirmed papillary carcinoma. Intraoperatively, enlarged cervical lymph nodes were palpable. Bilateral neck dissections and total thyroidectomy with parathyroid reimplantation were performed. On histological examination, the thyroid gland was not involved. The patient recovered uneventfully from the surgery and is planned for radioactive iodine therapy and thyroxine suppression, with subsequent follow-up with serum thyroid-stimulating hormone and thyroglobulin for surveillance. We review the literature and discuss challenges in the diagnosis and surgical management of this rare entity in the paediatric age group.
authors.affiliation: Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore.
authors.forename: Isaac
authors.initials: I
authors.lastname: Seow-En
authors.affiliation: Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore.
authors.forename: Amos Hong Pheng
authors.initials: AH
authors.lastname: Loh
authors.affiliation: Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
authors.forename: Derrick Wen Quan
authors.initials: DW
authors.lastname: Lian
authors.affiliation: Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore.
authors.forename: Shireen Anne
authors.initials: SA
authors.lastname: Nah
mesh_terms: D000293:Adolescent; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007455:Iodine; D008198:Lymph Nodes; D008297:Male; D037981:Neck Dissection; D010280:Parathyroid Glands; D013954:Thyroglobulin; D013955:Thyroglossal Cyst / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013961:Thyroid Gland / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D013965:Thyroidectomy; D013972:Thyrotropin; D013974:Thyroxine
chemical_list: D013972:Thyrotropin; D013954:Thyroglobulin; D007455:Iodine; D013974:Thyroxine