title: The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression.
abstract: Epithelial-mesenchymal transition and immunosuppression are crucial for cancer metastasis and treatment resistance. The mechanism by which these distinct processes are co-opted remains incompletely understood. Our recent work has exposed the "dirty affairs" of the 2 at the tumor site, thus calling for a combined therapy to break such a dangerous liaison.
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
authors.forename: Limo
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
authors.forename: John V
authors.initials: JV
authors.lastname: Heymach
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Center of Systems Medicine, Institute of Basic Medical Sciences , Suzhou, China ; Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, China.
authors.forename: F Xiao-Feng
authors.initials: FX
authors.lastname: Qin
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Department of Molecular and Cellular Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
authors.forename: Don L
authors.initials: DL
authors.lastname: Gibbons
keywords: epithelial–mesenchymal transition; immunosuppression; miRNA; therapy resistance; tumor microenvironment