title: Mechanochemical synthesis of zinc-apatitic calcium phosphate and the controlled zinc release for bone tissue engineering.
abstract: In this study, in order to control zinc (Zn)-release from calcium phosphate (CaP), the crystalline forms of CaP-containing Zn were modified by wet ball milling and/or heat treatment. The CaP (CaO:CaHPO4:ZnO = 7:20:3, molar ratio) was ground in a ball mill with the addition of purified water, and the ground products were heated to 400 °C and 800 °C. The physicochemical properties of these ground products were measured by powder X-ray diffraction (XRD), infrared spectroscopy (IR), scanning electron microscopy and energy-dispersive X-ray spectroscopy. Zn release characteristics from the samples were evaluated using a dissolution tester. The results of XRD and IR suggested that the structures of the starting materials were destroyed after 2.5 h of grinding, and new apatite-like amorphous solid containing Zn was generated. The Zn-release from the ground products was markedly suppressed after 2.5 h of grinding.
authors.affiliation: a Faculty of Pharmacy , Research Institute of Pharmaceutical Sciences, Musashino University , Tokyo , Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hattori
authors.affiliation: a Faculty of Pharmacy , Research Institute of Pharmaceutical Sciences, Musashino University , Tokyo , Japan.
authors.forename: Hiroe
authors.initials: H
authors.lastname: Mori
authors.affiliation: a Faculty of Pharmacy , Research Institute of Pharmaceutical Sciences, Musashino University , Tokyo , Japan.
authors.forename: Joshua
authors.initials: J
authors.lastname: Chou
authors.affiliation: a Faculty of Pharmacy , Research Institute of Pharmaceutical Sciences, Musashino University , Tokyo , Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Otsuka
mesh_terms: D001031:Apatites / Q000138:chemical synthesis* / Q000378:metabolism; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000138:chemical synthesis* / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000378:metabolism; D023822:Tissue Engineering / Q000379:methods*; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001031:Apatites; D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; C020243:calcium phosphate; D015032:Zinc
keywords: Controlled zinc release system; energy-dispersive X-ray spectroscopy; infrared spectroscopy; powder X-ray dif fraction; wet ball milling; zinc-containing apatite-related calcium phosphate