title: Multicystic dedifferentiated retroperitoneal liposarcoma: tumour cyst fluid analysis and implications for management.
abstract: Liposarcomas are soft tissue sarcomas of adipocyte origin. We describe a case of a dedifferentiated retroperitoneal liposarcoma with an unusual presentation on recurrence as a large, multicystic tumour. The patient was a 72-year-old woman who had undergone multiple treatments including two prior resections. For her most recent locoregional disease recurrence, the patient was offered surgical debulking for symptom palliation. At this operation, performed after two cycles of chemotherapy, the tumour cyst fluid was analysed and found to have a predominance of immune cells with no identifiable malignant cells. This case and the results of our tumour cyst fluid analysis raise several interesting considerations for the management of this unique situation in a rare disease.
authors.affiliation: Department of Surgery, Section of Surgical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Mitri
authors.initials: M
authors.lastname: Khoury
authors.affiliation: Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL.
authors.forename: Geok Choo
authors.initials: GC
authors.lastname: Sim
authors.affiliation: Department of Breast Surgical Oncology, Tochigi Cancer Center, Utsunomiya, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Harao
authors.affiliation: Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL Lion Biotechnologies, Woodland Hills, CA.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Radvanyi
authors.affiliation: Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Behrang
authors.initials: B
authors.lastname: Amini
authors.affiliation: Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Benjamin
authors.affiliation: University Health Care System, Toronto, Canada.
authors.forename: Peter W T
authors.initials: PW
authors.lastname: Pisters
authors.affiliation: Division of Surgical Oncology, The James Cancer Center, Ohio State University, Columbus, OH.
authors.forename: Raphael E
authors.initials: RE
authors.lastname: Pollock
authors.affiliation: Department of Surgery, Section of Surgical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA Sarcoma Program, Hoag Family Cancer Institute and Hoag Memorial Hospital Presbyterian, Newport Beach, CA.
authors.forename: William W
authors.initials: WW
authors.lastname: Tseng
mesh_terms: D000368:Aged; D020420:Cyst Fluid; D003560:Cysts / Q000601:surgery*; D019468:Disease Management; D005260:Female; D006801:Humans; D008080:Liposarcoma / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D012186:Retroperitoneal Neoplasms / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000473:pathology / Q000601:surgery