title: Platelets and Their Interactions with Other Immune Cells.
abstract: Platelets are anucleate blood cells, long known to be critically involved in hemostasis and thrombosis. In addition to their role in blood clots, increasing evidence reveals significant roles for platelets in inflammation and immunity. However, the notion that platelets represent immune cells is not broadly recognized in the field of Physiology. This article reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions.
authors.affiliation: Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas, USA.|Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.
authors.forename: Fong W
authors.initials: FW
authors.lastname: Lam
authors.affiliation: Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas, USA.|Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.|Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.|Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.
authors.forename: K Vinod
authors.initials: KV
authors.lastname: Vijayan
authors.affiliation: Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas, USA.|Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.|Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.
authors.forename: Rolando E
authors.initials: RE
authors.lastname: Rumbaut
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D018925:Chemokines / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D013927:Thrombosis / Q000276:immunology*; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism
chemical_list: D018925:Chemokines; D016207:Cytokines; D051193:Toll-Like Receptors