title: Short communication: mucocutaneous leishmaniasis in HIV-related immune reconstitution syndrome.
abstract: Immune reconstitution inflammatory syndrome (IRIS) is an immuno-pathologic reaction to quiescent opportunistic microbial pathogens upon restoration of underlying immune defects. Here we report a Honduran patient with HIV/AIDS who developed a facial rash worsening on antiretroviral therapy and increasing CD4 count. Culture and PCR analysis from the skin biopsy identified Leishmania panamensis, which was effectively treated with long-term liposomal amphotericin B. This is the first report of mucocutaneous leishmaniasis (MCL)-associated IRIS due to L. panamensis.
authors.affiliation: 1 Division of Dermatology, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
authors.forename: Grace L
authors.initials: GL
authors.lastname: Lee
authors.affiliation: 2 Division of Infectious Diseases, Department of Internal Medicine, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Woods
authors.affiliation: 3 Division of Dermatopathology, Department of Pathology, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Clark
authors.affiliation: 3 Division of Dermatopathology, Department of Pathology, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
authors.forename: Sara
authors.initials: S
authors.lastname: Peters
authors.affiliation: 1 Division of Dermatology, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
authors.forename: Henry K
authors.initials: HK
authors.lastname: Wong
authors.affiliation: 2 Division of Infectious Diseases, Department of Internal Medicine, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
authors.forename: Bradford S
authors.initials: BS
authors.lastname: McGwire
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000276:immunology; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications* / Q000276:immunology; D007891:Leishmania; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D016133:Polymerase Chain Reaction
chemical_list: D000981:Antiprotozoal Agents; D000666:Amphotericin B