title: Antimicrobial films based on cellulose-derived hydrocolloids. A synergetic effect of host-guest interactions on quality and functionality.
abstract: A series of active films based on biodegradable cellulose-derived hydrocolloids capable of controlled release of antimicrobial propionic acid (PA) was prepared. β-Cyclodextrin (β-CD), usually used for encapsulation of lipophilic compounds, was utilized in this research to host the hydrophilic PA. It was found that addition of β-CD to the film forming solutions notably enhanced the hydrocolloid matrix capacity and resulted in up to a ten-fold increase in the amount of uploaded PA. In addition, β-CD resulted in a two-fold prolongation of the effective PA release duration. β-CD alone caused undesired effects on the physical, mechanical and morphological properties of the hydrocolloid films. Interestingly, when β-CD was combined with PA in the film formulation, its undesired effects were significantly subdued. The antifungal activity of the films was demonstrated on fresh harvested wheat grains. Films containing β-CD and PA were found to be effective in preventing fungal growth on wheat grains. Thus, incorporation of β-CD and PA in hydrocolloids matrices demonstrated a synergetic effect and resulted in the formation of biodegradable active films that benefit good physical and mechanical properties, high active agent content, prolonged release ability and effective antimicrobial properties.
authors.affiliation: Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel; Department of Food Quality and Safety, Agricultural Research Organization, The Volcani Center, Bet-Dagan 50250, Israel.
authors.forename: Roi
authors.initials: R
authors.lastname: Rutenberg
authors.affiliation: Department of Food Quality and Safety, Agricultural Research Organization, The Volcani Center, Bet-Dagan 50250, Israel.
authors.forename: Solange
authors.initials: S
authors.lastname: Bernstein
authors.affiliation: Department of Food Quality and Safety, Agricultural Research Organization, The Volcani Center, Bet-Dagan 50250, Israel.
authors.forename: Nachman
authors.initials: N
authors.lastname: Paster
authors.affiliation: Department of Food Quality and Safety, Agricultural Research Organization, The Volcani Center, Bet-Dagan 50250, Israel.
authors.forename: Eli
authors.initials: E
authors.lastname: Fallik
authors.affiliation: Department of Food Quality and Safety, Agricultural Research Organization, The Volcani Center, Bet-Dagan 50250, Israel. Electronic address: elenap@volcani.agri.gov.il.
authors.forename: Elena
authors.initials: E
authors.lastname: Poverenov
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000737:chemistry*; D003102:Colloids; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D013818:Thermogravimetry; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D003102:Colloids; D047392:beta-Cyclodextrins; D002482:Cellulose; C031215:betadex
keywords: Antimicrobial; Bio-active hydrocolloids; Cellulose derivatives; Controlled release; Propionic acid; β-Cyclodextrin