title: Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.
abstract: This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.
authors.affiliation: 1. CHR Metz-Thionville, Hôpital de Mercy, Service de radiothérapie, 1 allée du Château, Ars-Laquenexy, 57530, France; ; 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;
authors.forename: Paul
authors.initials: P
authors.lastname: Retif
authors.affiliation: 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;
authors.forename: Sophie
authors.initials: S
authors.lastname: Pinel
authors.affiliation: 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;
authors.forename: Magali
authors.initials: M
authors.lastname: Toussaint
authors.affiliation: 4. Université de Lorraine, LRGP, UMR 7274, 1 rue Grandville, Nancy, 54000, France; ; 5. CNRS, LRGP, UMR 7274, 1 rue Grandville, Nancy, 54000, France;
authors.forename: Céline
authors.initials: C
authors.lastname: Frochot
authors.affiliation: 4. Université de Lorraine, LRGP, UMR 7274, 1 rue Grandville, Nancy, 54000, France; ; 5. CNRS, LRGP, UMR 7274, 1 rue Grandville, Nancy, 54000, France;
authors.forename: Rima
authors.initials: R
authors.lastname: Chouikrat
authors.affiliation: 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 6. Université de Lorraine, INRIA-BIGS & CRAN, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Bastogne
authors.affiliation: 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;
authors.forename: Muriel
authors.initials: M
authors.lastname: Barberi-Heyob
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D060733:Electromagnetic Radiation; D053758:Nanoparticles / Q000008:administration & dosage*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D011878:Radiotherapy / Q000379:methods*; D014965:X-Rays
chemical_list: D011838:Radiation-Sensitizing Agents
keywords: Cancer; Nanoparticles; Photodynamic therapy.; Radiation therapy; Radiobiology; Radiosensitization