title: Six new prenylated acetophenone derivatives from the leaves of Acronychia oligophlebia.
abstract: Six new prenylated acetophenone derivatives were isolated from the leaves of Acronychia oligophlebia. The chemical structures of them were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The cytotoxic activity of the isolates was evaluated against MCF-7 cells. Among these compounds, 2 and 6 exhibited mild cytotoxic activity with IC50 values of 33.5 and 25.6 μM, respectively.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Xian
authors.initials: X
authors.lastname: Yang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Zhong-Nan
authors.initials: ZN
authors.lastname: Wu
authors.affiliation: Department of Biochemistry, The School of Medicine, Jinan University, Guangzhou 510632, PR China.
authors.forename: Xiang-Qiang
authors.initials: XQ
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry, The School of Medicine, Jinan University, Guangzhou 510632, PR China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Jiang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, PR China. Electronic address: tliyl@jnu.edu.cn.
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, PR China. Electronic address: twangguocai@jnu.edu.cn.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D054876:Prenylation; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000972:Antineoplastic Agents, Phytogenic; C038699:acetophenone
keywords: Acronychia oligophlebia; Cytotoxic activity; Prenylated acetophenone