title: Clear cell carcinoma of the nasal cavity: A case report from histopathological viewpoint.
abstract: We report an extremely rare case of primary clear cell carcinoma (CCC), not otherwise specified (NOS) of the nasal cavity. An 80-year-old woman was referred to our hospital with left nasal obstruction caused by a nasal cavity tumor. The tumor was resected completely with lateral rhinotomy approach. Histopathological examination revealed CCC. CCC metastasis from renal cell carcinoma (RCC), which is at the top of differential diagnosis, was ruled out by the absence of renal tumor at computed tomography (CT). Also, immunohistochemical results of the specimen with vimentin negative and CK7 focally positive excluded the possibility of RCC metastasis. The patient is free from recurrence 1 year after the surgery, and there is no evidence of RCC. In this report histopathological characteristics, especially immunohistochemical properties of primary CCC, NOS of the nasal cavity are presented together with some clinical features of this rare tumor. Also, we refer to histopathogenesis of primary CCC of nasal cavity in relation to myoepithelial carcinoma. Histopathological discussion is further extended to include other CCC and CCC-resembling histologies to confirm the uniqueness of the present case.
authors.affiliation: Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan. Electronic address: takayuki.imai629@gmail.com.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Imai
authors.affiliation: Department of Pathology, Miyagi Cancer Center, Natori, Miyagi, Japan.
authors.forename: Ikuro
authors.initials: I
authors.lastname: Satoh
authors.affiliation: Department of Diagnostic Radiology, Miyagi Cancer Center, Natori, Miyagi, Japan.
authors.forename: Ko
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Pathology, Miyagi Cancer Center, Natori, Miyagi, Japan.
authors.forename: Shigemi
authors.initials: S
authors.lastname: Ito
authors.affiliation: Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Asada
authors.affiliation: Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Kato
authors.affiliation: Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan.
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Koshiba
authors.affiliation: Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saijo
authors.affiliation: Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Matsuura
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D015508:Nasal Obstruction / Q000209:etiology; D009669:Nose Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000378:metabolism
chemical_list: D014746:Vimentin; D007633:Keratins
keywords: Clear cell carcinoma NOS; Hyalinizing clear cell carcinoma; Myoepithelial carcinoma; Nasal cavity; Renal cell carcinoma; Sinonasal renal cell-like adenocarcinoma