title: Fluorescence switching method for cascade detection of salicylaldehyde and zinc(II) ion using protein protected gold nanoclusters.
abstract: A new fluorescence switching sensor for cascade detection of salicylaldehyde (SA) and Zinc(II) ion was developed based on bovine serum albumin protected gold nanoclusters (BSA-AuNCs). In the detection, SA interacted with amino groups of BSA-AuNCs, inducing simultaneous formation of fluorescent Schiff base and fluorescence quenching of AuNCs. Zn(II) could further strongly coordinate with the Schiff base ligands, leading to blue-shift and increase of the fluorescence from Schiff base-metal coordination complexes and simultaneous recovery of fluorescence from AuNCs. The new fluorescence switching sensor for Zn(2+) detection has advantages of simplicity, rapidity, naked-eye detection, high sensitivity and selectivity. The linear range of the method for Zn(2+) detection is from 0.1 μM to 100 μM with the limit of detection (LOD) of 29.28 nM. In practical samples, the recoveries of the samples ranged from 99.63% to 100.58%.
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No. 29, Zhongguancun, East Road, Beijing 100190, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No. 29, Zhongguancun, East Road, Beijing 100190, People's Republic of China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No. 29, Zhongguancun, East Road, Beijing 100190, People's Republic of China.
authors.forename: Xiangling
authors.initials: X
authors.lastname: Ren
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No. 29, Zhongguancun, East Road, Beijing 100190, People's Republic of China. Electronic address: liuhy@mail.ipc.ac.cn.
authors.forename: Huiyu
authors.initials: H
authors.lastname: Liu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No. 29, Zhongguancun, East Road, Beijing 100190, People's Republic of China. Electronic address: linlinli@mail.ipc.ac.cn.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No. 29, Zhongguancun, East Road, Beijing 100190, People's Republic of China. Electronic address: mengxw@mail.ipc.ac.cn.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D000447:Aldehydes / Q000032:analysis* / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000295:instrumentation*; D015032:Zinc / Q000032:analysis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D020099:Coated Materials, Biocompatible; C013243:salicylaldehyde; D012710:Serum Albumin, Bovine; D006046:Gold; D015032:Zinc
keywords: Coordination; Fluorescence switching; Gold nanoclusters; Salicylaldehyde; Schiff base; Zn(2+)