title: Electrostatic Polyion Micelles with Fluorescence and MRI Dual Functions.
abstract: We report in this work the formation of fluorescence and MRI bimodal imaging nanoparticles achieved by electrostatic self-assembly. The nanoparticles are micelles formed with Gd(3+) ion, a bisligand that contains aggregation induced emission (AIE) group, and a block copolymer. The coordination between the Gd(3+) ion and the bisligand produces a negatively charged coordination complex, which interacted with the positive-neutral block copolymer to form polyion micelles. The micelles exhibit considerable fluorescence owing to the rotation restriction of the AIE group; meanwhile, the longitudinal relaxation of water was significantly slowed down which provide T1 contrast for magnetic resonance imaging. In vitro fluorescence imaging and in vivo MRI measurements verified this micelle indeed exhibit dual imaging ability. We expect that this orthogonal imaging may provide more accurate diagnosis in practical applications and will pave the way for the development of an advanced technique for diagnosis.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yan
mesh_terms: D005453:Fluorescence; D008279:Magnetic Resonance Imaging; D008823:Micelles; D011108:Polymers / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D008823:Micelles; D011108:Polymers