title: [Expression of adiponectin in non-small cell lung cancer and its relationship with MMP-9 and angiogenesis].
abstract: BACKGROUND
  To explore the expression of adiponectin and its relationship with matrix metalloproteinase (MMP)-9 and angiogenesis in non-small cell lung cancer (NSCLC) tissue.
  
  
  METHODS
  A total of 87 samples of NSCLC and 10 samples of normal lung tissue were collected for detection of adiponectin and MMP-9 expression by immunohistochemical method. Anti-CD34 monoclonal antibody against endothelial marker was used to evaluate microvessel density (MVD).
  
  
  RESULTS
  The positive rate for adiponectin in NSCLC (49.43%) was significantly lower than that in normal lung tissues (90.00%) while for MMP-9 in NSCLC (59.77%) was significantly higher than that in normal lung tissues (10.00%, P<0.05); MVD in NSCLC (14.58 ± 0.67) was higher than that in normal lung tissues [(0.80 ± 0.12), P<0.05]. In NSCLC, the positive rates of adiponectin and MMP-9 were varied in groups with different lymph node metastasis, tumor size and clinical stage (P<0.05). Meanwhile, MVD value in NSCLC with or without lymph node metastasis was significantly different. There was a negative correlation between adiponectin level and CD34 (MVD) or MMP-9 level (r=-0.22 or r=-0.55, respectively, P<0.05). On the contrary, MMP-9 was positively correlated with MVD (r=0.21, P<0.05).
  
  
  CONCLUSIONS
  The decreased expression of adiponectin might be related to the development of NSCLC through negative regulation of MMP-9 expression. .
authors.affiliation: Department of Respiratory Disease, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Respiratory Disease, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Lanyan
authors.initials: L
authors.lastname: Zhu
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000378:metabolism*; D008207:Lymphatic Metastasis; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009389:Neovascularization, Pathologic
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9