title: Synthesis of a new class of iminosugars based on constrained azaspirocyclic scaffolds by way of catalytic C-H amination.
abstract: The synthesis of the first examples of a new class of iminosugars based on constrained spirocyclic scaffolds has been achieved via Rh-catalyzed C(sp(3))-H amination. In this process, the needed electronic control in securing high regioselectivity from substrates with a high density of activated C-H bonds was achieved by using a combination of activating and electron-withdrawing groups.
authors.affiliation: Laboratoire de Synthèse Organique et Molécules Bioactives (SYBIO), Université de Strasbourg/CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, 67087 Strasbourg, France. philippe.compain@unistra.fr.
authors.forename: Pierre-Antoine
authors.initials: PA
authors.lastname: Nocquet
authors.forename: Raphaël
authors.initials: R
authors.lastname: Hensienne
authors.forename: Joanna
authors.initials: J
authors.lastname: Wencel-Delord
authors.forename: Eric
authors.initials: E
authors.lastname: Wimmer
authors.forename: Damien
authors.initials: D
authors.lastname: Hazelard
authors.forename: Philippe
authors.initials: P
authors.lastname: Compain