title: Insulin-like growth factor 1 receptor expression in breast cancer tissue and mammographic density.
abstract: The aim of this study was to evaluate the association between insulin-like growth factor 1 receptor (IGF-1R) expression in breast cancer tissue and mammographic density and the clinical significance of IGF-1R overexpression. A total of 167 patients with primary invasive breast cancer were analyzed. Mammographic breast density and IGF-1R overexpression were correlated with clinicopathological parameters and analyzed by overall survival (OS) and disease-free survival (DFS). Increased breast tissue density was significantly associated with age, body mass index, menopausal status, histological grade and IGF-1R overexpression in the univariate analysis and with age (P=0.001), histological grade (P=0.045) and IGF-1R overexpression (P=0.021) in the multivariate analysis. IGF-1R overexpression was significantly associated with dense breast tissue in patients aged >40 years (P=0.002). IGF-1R overexpression in breast cancer in premenopausal women was associated with human epidermal growth factor receptor 2 (HER-2) positivity (P=0.016) and worse DFS (P=0.0414). There was no significant difference in OS and DFS between dense and non-dense breast tissue. IGF-1R expression in breast cancer tissue was significantly associated with mammographic breast tissue density in patients aged >40 years. It appears that IGF-1R expression in breast cancer tissue plays an important role in breast cancer in patients with dense breast tissue. In premenopausal women, IGF-1R overexpression in breast cancer tissue was significantly associated with HER-2 positivity and poor DFS.
authors.affiliation: Department of Surgery, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon 301-723, Republic of Korea.
authors.forename: Woo-Young
authors.initials: WY
authors.lastname: Sun
authors.affiliation: Department of Surgery, College of Medicine and Medical Research Institute, Cheongju, Chungcheong 361-763, Republic of Korea.
authors.forename: Hyo-Young
authors.initials: HY
authors.lastname: Yun
authors.affiliation: Department of Surgery, College of Medicine and Medical Research Institute, Cheongju, Chungcheong 361-763, Republic of Korea.
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Song
authors.affiliation: Department of Preventive Medicine, College of Medicine and Medical Research Institute, Cheongju, Chungcheong 361-763, Republic of Korea.
authors.forename: Heon
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Pathology, Chungbuk National University, College of Medicine and Medical Research Institute, Cheongju, Chungcheong 361-763, Republic of Korea.
authors.forename: Ok-Jun
authors.initials: OJ
authors.lastname: Lee
authors.affiliation: Department of Surgery, Samsung Medical Center, Seoul 135-710, Republic of Korea.
authors.forename: Seok-Jin
authors.initials: SJ
authors.lastname: Nam
authors.affiliation: Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.
authors.forename: Ja-Seung
authors.initials: JS
authors.lastname: Koo
keywords: breast neoplasm; density; immunohistochemistry; insulin-like growth factor 1 receptor; mammography