title: The disengagement of visual attention in Alzheimer's disease: a longitudinal eye-tracking study.
abstract: BACKGROUND
  Eye tracking provides a convenient and promising biological marker of cognitive impairment in patients with neurodegenerative disease. Here we report a longitudinal study of saccadic eye movements in a sample of patients with Alzheimer's disease and elderly control participants who were assessed at the start of the study and followed up 12-months later.
  
  
  METHODS
  Eye movements were measured in the standard gap and overlap paradigms, to examine the longitudinal trends in the ability to disengage attention from a visual target.
  
  
  RESULTS
  Overall patients with Alzheimer's disease had slower reaction times than the control group. However, after 12-months, both groups showed faster and comparable reductions in reaction times to the gap, compared to the overlap stimulus. Interestingly, there was a general improvement for both groups with more accurately directed saccades and speeding of reaction times after 12-months.
  
  
  CONCLUSIONS
  These findings point to the value of longer-term studies and follow-up assessment to ascertain the effects of dementia on oculomotor control.
authors.affiliation: Dementia Research and Eye Tracking Lab, Department of Psychology, Centre of Aging Research, Centre for Learning and Human Development, Lancaster University Lancaster, UK.
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Crawford
authors.affiliation: Dementia Research and Eye Tracking Lab, Department of Psychology, Centre of Aging Research, Centre for Learning and Human Development, Lancaster University Lancaster, UK.
authors.forename: Alex
authors.initials: A
authors.lastname: Devereaux
authors.affiliation: Dementia Research and Eye Tracking Lab, Department of Psychology, Centre of Aging Research, Centre for Learning and Human Development, Lancaster University Lancaster, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Higham
authors.affiliation: Dementia Research and Eye Tracking Lab, Department of Psychology, Centre of Aging Research, Centre for Learning and Human Development, Lancaster University Lancaster, UK.
authors.forename: Claire
authors.initials: C
authors.lastname: Kelly
keywords: Alzheimer's disease; attention; cognition; dementia; eye-tracking