title: Radiotherapy treatment of large esophageal leiomyosarcoma: A case report.
abstract: Leiomyosarcoma of the esophagus is a rare type of tumor, characterized by a malignant phenotype and smooth muscle histology. Previously, barium studies have been used to identify areas of luminal narrowing, expansile intraluminal masses or large intramural masses with ulceration or tracking. Furthermore, endoscopic biopsies appear to be associated with a high false negative rate, particularly in cases where the mucosa is intact. The optimal treatment strategy is surgical resection, while the role of adjuvant radiotherapy and chemotherapy is controversial. In addition, the prognosis of patients with leiomyosarcoma of the esophagus is improved compared with patients suffering from squamous esophageal cancer. The present study described the case of a 48-year-old woman who presented with dysphagia and was diagnosed with a large leiomyosarcoma of the esophagus. The patient was successfully treated with radiotherapy and remains disease-free two years after the completion of treatment. In addition, the present study conducted a review of the relevant literature, reporting previous cases of esophageal leiomyosarcoma and potential strategies for the management of this disease.
authors.affiliation: Department of Surgical Oncology (Interventional Therapy), Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Surgical Oncology (Interventional Therapy), Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Bu
authors.affiliation: Department of Computerized Tomography, Shandong Medical Imaging Research Institute, Jinan, Shandong 250000, P.R. China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Surgical Oncology (Interventional Therapy), Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Sixth Ward of Shandong Mental Health Center, Jinan, Shandong 250014, P.R. China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Shi
authors.affiliation: Department of Surgical Oncology (Interventional Therapy), Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Surgical Oncology (Interventional Therapy), Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
keywords: esophagus; leiomyosarcoma; radiotherapy