title: [Eosinophilic esophagitis].
abstract: Eosinophilic esophagitis (EoE) is a clinicopathologic condition of increasing recognition and prevalence. Because of elevated total IgE levels and high rates of concurrent allergic diseases compared with the general population, EoE appears to be an antigen-driven immunologic process that caused by allergens like food or aeroallergens. EoE is a disease that features dense intraepithelial infiltration by eosinophils which cause excessive mucosal immunologic reactions which cause several symptoms that mostly involve dysphagia. For establishment of the diagnosis, infiltration of eosinophils (≥ 20 eosinophils/HPF) should be identified in an esophageal mucosal biopsy specimen. In treatment of patients have a possibility of EoE, proton-pump inhibitors(PPIs) must be tried as first choice. Other proved therapeutic options include topical or systemic corticosteroids, chronic dietary elimination, and esophageal dilation, but local administration of glucocorticoids has recently been reported as useful therapy for EoE.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kusunose
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ohara
mesh_terms: D000328:Adult; D000368:Aged; D057765:Eosinophilic Esophagitis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors