title: Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery.
abstract: PEGylation in polymeric nanomedicine has gained substantial predominance in biomedical applications due to its resistance to protein absorption, which is critically important for a therapeutic delivery system in blood circulation. The shielding layer of PEGylation, however, creates significant steric hindrance that negatively impacts cellular uptake and intracellular distribution at the target site. This unexpected effect compromises the biological efficacy of the encapsulated payload. To address this issue, one of the key strategies is to tether the disulfide bond to PEG for constructing a disulfide-bridged cleavable PEGylation. The reversible disulfide bond can be cleaved to enable selective PEG detachment. This article provides an overview on the strategy, method and progress of PEGylation nanosystem with the cleavable disulfide bond.
authors.affiliation: Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science (iNANO), Tongji University School of Medicine, Shanghai, China.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Dong
authors.affiliation: Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science (iNANO), Tongji University School of Medicine, Shanghai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Tang
authors.affiliation: Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science (iNANO), Tongji University School of Medicine, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science (iNANO), Tongji University School of Medicine, Shanghai, China.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Mechanical Engineering, University of Texas at Dallas, TX 75080, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Qian
authors.affiliation: Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science (iNANO), Tongji University School of Medicine, Shanghai, China.|The Materials Science & Engineering Program, Department of Mechanical & Materials Engineering, College of Engineering & Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: Donglu
authors.initials: D
authors.lastname: Shi
mesh_terms: D003432:Cross-Linking Reagents / Q000138:chemical synthesis; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis*; D004220:Disulfides / Q000737:chemistry*; D015195:Drug Design; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004220:Disulfides; D053769:Nanocapsules; D011092:Polyethylene Glycols
keywords: cleavable PEGylation; disulfide bond; drug delivery; gene delivery; micelles; prodrug; vesicles