title: The role of chromatin repressive marks in cognition and disease: A focus on the repressive complex GLP/G9a.
abstract: Histone post-translational modifications are key epigenetic processes controlling the regulation of gene transcription. In recent years it has become apparent that chromatin modifications contribute to cognition through the modulation of gene expression required for the expression and consolidation of memories. In this review, we focus on the role of histone methylation in the nervous system. Histone methylation is involved in a number of cognitive disturbances, such as intellectual disability, cocaine addiction and age-related cognitive decline. We provide an overview of the dynamic changes in methylation of histone lysine residues during learning and memory. With a special focus on H3K9 histone methyltransferases GLP and G9a, we summarize the effects of deficiencies in writer and eraser enzymes on neuronal plasticity and cognition.
authors.affiliation: Department of Cognitive Neuroscience, Radboudumc, 6500 HB Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, The Netherlands.
authors.forename: Marco
authors.initials: M
authors.lastname: Benevento
authors.affiliation: Department of Cognitive Neuroscience, Radboudumc, 6500 HB Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, The Netherlands.
authors.forename: Marise
authors.initials: M
authors.lastname: van de Molengraft
authors.affiliation: Department of Cognitive Neuroscience, Radboudumc, 6500 HB Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, The Netherlands.
authors.forename: Rhode
authors.initials: R
authors.lastname: van Westen
authors.affiliation: Department of Cognitive Neuroscience, Radboudumc, 6500 HB Nijmegen, The Netherlands; Department of Human Genetics, Radboudumc, 6500 HB Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, The Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: van Bokhoven
authors.affiliation: Department of Cognitive Neuroscience, Radboudumc, 6500 HB Nijmegen, The Netherlands; Department of Human Genetics, Radboudumc, 6500 HB Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, The Netherlands. Electronic address: n.nadif@donders.ru.nl.
authors.forename: Nael Nadif
authors.initials: NN
authors.lastname: Kasri
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002843:Chromatin / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000235:genetics*; D044127:Epigenesis, Genetic; D006649:Histocompatibility Antigens / Q000378:metabolism*; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology; D008745:Methylation; D009473:Neuronal Plasticity / Q000235:genetics; D009474:Neurons / Q000378:metabolism; D019966:Substance-Related Disorders / Q000235:genetics
chemical_list: D002843:Chromatin; D006649:Histocompatibility Antigens; C455847:EHMT1 protein, human; C445405:EHMT2 protein, human; D011495:Histone-Lysine N-Methyltransferase
keywords: Epigenetics; G9a; GLP; Histone methylation; Learning and memory