title: Mean platelet volume and left ventricular geometry in patients with aortic valve stenosis.
abstract: BACKGROUND
  Mean platelet volume (MPV) is a well-established marker of platelet activation. In the current study, we compared MPV between patients with aortic valve stenosis (AS) and control subjects. We also assessed the association between MPV and left ventricular geometry in patients with AS.
  
  
  RESULTS
  The study population consisted of 75 patients with AS and 38 age- and sex-matched control subjects. In patients with AS, peak pressure gradient was 83.0 ± 30.8 mm Hg. MPV was significantly larger in patients with AS than control subjects (10.57 ± 1.05 fl versus 9.72 ± 0.66 fl, p < 0.001). There was a significant association between peak pressure gradient and MPV in 75 patients with AS and 38 control subjects (r = 0.35, p < 0.001). Among the patients with AS, there were 12 patients with normal geometry, 10 patients with concentric remodeling, 14 patients with eccentric hypertrophy and 39 patients with concentric hypertrophy. There was no significant difference in MPV among the four groups. There was no significant association between MPV and LVM index.
  
  
  CONCLUSIONS
  Our data suggested that MPV increased in patients with AS, but did not reflect left ventricular geometry.
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kurisu
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Tadanao
authors.initials: T
authors.lastname: Higaki
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikenaga
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Watanabe
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimonaga
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Iwasaki
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Ishibashi
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Dohi
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Fukuda
authors.affiliation: a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Kihara
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods*; D020257:Ventricular Remodeling / Q000502:physiology*
keywords: Aortic valve; platelet; ventricular hypertrophy