title: [Dual role for prostaglandin D2 in intestinal epithelial homeostasis].
abstract: Prostaglandin D2 (PGD2) and derivatives are lipid mediators involved in the control of the intestinal epithelial barrier homeostasis. Their involvement in the pathophysiology of chronic inflammatory bowel disease (IBD) is still debated. Several results highlight the duality of PGD2 as an anti- or pro-inflammatory mediator. This duality seems to be related to a differential expression of its receptors by intestinal epithelial cells and the surrounding immunocompetent cells. The enteric glial cells from the enteric nervous system (ENS) express the lipocalin-type-prostaglandin D synthase and secrete PGD2 and 15d-PGJ2. The protective role of the ENS in the homeostatic control of the epithelial intestinal barrier and its involvement in the pathogenesis of IBD have already been demonstrated. Thus, these lipid mediators seem to be new actors of the neuro-glio-epithelial unit and could play a crucial role maintaining gut barrier integrity.
authors.affiliation: Inserm UMR913, institut des maladies de l'appareil digestif, Université de Nantes, CHU Hôtel-Dieu, 1, place Alexis Ricordeau, 44093 Nantes, France - Laboratoire de Biochimie, institut de biologie, CHU Nantes, 9, quai Moncousu, 44093 Nantes, France.
authors.forename: Anne-Gaelle
authors.initials: AG
authors.lastname: Le Loupp
authors.affiliation: Inserm UMR913, institut des maladies de l'appareil digestif, Université de Nantes, CHU Hôtel-Dieu, 1, place Alexis Ricordeau, 44093 Nantes, France - Laboratoire de Biochimie, institut de biologie, CHU Nantes, 9, quai Moncousu, 44093 Nantes, France.
authors.forename: Kalyane
authors.initials: K
authors.lastname: Bach-Ngohou
authors.affiliation: Inserm UMR913, institut des maladies de l'appareil digestif, Université de Nantes, CHU Hôtel-Dieu, 1, place Alexis Ricordeau, 44093 Nantes, France.
authors.forename: Armel
authors.initials: A
authors.lastname: Bettan
authors.affiliation: Inserm UMR913, institut des maladies de l'appareil digestif, Université de Nantes, CHU Hôtel-Dieu, 1, place Alexis Ricordeau, 44093 Nantes, France - Laboratoire de Biochimie, institut de biologie, CHU Nantes, 9, quai Moncousu, 44093 Nantes, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Denis
authors.affiliation: Inserm UMR913, institut des maladies de l'appareil digestif, Université de Nantes, CHU Hôtel-Dieu, 1, place Alexis Ricordeau, 44093 Nantes, France - Laboratoire de Biochimie, institut de biologie, CHU Nantes, 9, quai Moncousu, 44093 Nantes, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Masson
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000473:pathology; D007413:Intestinal Mucosa / Q000502:physiology*; D008055:Lipids / Q000494:pharmacology; D019899:Paracrine Communication; D015230:Prostaglandin D2 / Q000502:physiology*
chemical_list: D008055:Lipids; D015230:Prostaglandin D2