title: Amantadine to Treat Cognitive Dysfunction in Moderate to Severe Traumatic Brain Injury.
abstract: Traumatic brain injury (TBI) is a leading cause of injury, disability, and death in the United States. Amantadine is an established dopamine agonist that supports neurological function. The purpose of this literature review was to determine whether amantadine improves cognitive function post-TBI. PubMed and CINAHL were used to search the literature for articles using amantadine to treat TBI from 1994 to 2004. Outcomes were summarized and the evidence was appraised. Although earlier studies from 1994 to 2003 were lower-level studies and recommended further research on treatment of cognitive dysfunction in TBI, the literature from 2004 to present generally concluded that amantadine improved cognitive function related to arousal, memory, and aggression. It can be started days to months postinjury and still produces benefits.
authors.affiliation: Inpatient Trauma Services (Ms Stelmaschuk), Grant Medical Center, Columbus, Ohio; Central Ohio Primary Care (Ms Will), Columbus, Ohio; and Outpatient Trauma and Acute Care Surgery Office (Ms Meyers), Grant Medical Center, Columbus, Ohio.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Stelmaschuk
authors.forename: Mary Colleen
authors.initials: MC
authors.lastname: Will
authors.forename: Tamara
authors.initials: T
authors.lastname: Meyers
mesh_terms: D000328:Adult; D000547:Amantadine / Q000008:administration & dosage*; D000070642:Brain Injuries, Traumatic / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000547:Amantadine