title: Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors.
abstract: Myeloid cells contribute to increased malignancy and poor prognosis in breast cancer. We demonstrate that anti-CSF-1R therapy depletes a cell population sharing characteristics of tumor-associated macrophages (TAMs) and dendritic cells (DCs). Intravital imaging combined with cellular characterization has refined our understanding of anti-CSF-1R therapy on the tumor microenvironment.
authors.affiliation: Department of Anatomy; University of California ; San Francisco, CA, USA.
authors.forename: Amy-Jo
authors.initials: AJ
authors.lastname: Casbon
authors.affiliation: Department of Anatomy; University of California ; San Francisco, CA, USA.
authors.forename: Marja
authors.initials: M
authors.lastname: Lohela
authors.affiliation: Department of Anatomy; University of California ; San Francisco, CA, USA.
authors.forename: Zena
authors.initials: Z
authors.lastname: Werb
keywords: M-CSF; MMP, matrix metalloproteinase; TAM, tumor-associated macrophages; breast cancer; matrix metalloproteinase; tumor microenvironment; tumor-associated macrophages