title: Neuropeptide Y genotype, central obesity, and abdominal fat distribution: the POUNDS LOST trial.
abstract: BACKGROUND
  Neuropeptide Y is a key peptide affecting adiposity and has been related to obesity risk. However, little is known about the role of NPY variations in diet-induced change in adiposity.
  
  
  OBJECTIVE
  The objective was to examine the effects of NPY variant rs16147 on central obesity and abdominal fat distribution in response to dietary interventions.
  
  
  METHODS
  We genotyped a functional NPY variant rs16147 among 723 participants in the Preventing Overweight Using Novel Dietary Strategies trial. Changes in waist circumference (WC), total abdominal adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue (SAT) from baseline to 6 and 24 mo were evaluated with respect to the rs16147 genotypes. Genotype-dietary fat interaction was also examined.
  
  
  RESULTS
  The rs16147 C allele was associated with a greater reduction in WC at 6 mo (P < 0.001). In addition, the genotypes showed a statistically significant interaction with dietary fat in relation to WC and SAT (P-interaction = 0.01 and 0.04): the association was stronger in individuals with high-fat intake than in those with low-fat intake. At 24 mo, the association remained statistically significant for WC in the high-fat diet group (P = 0.02), although the gene-dietary fat interaction became nonsignificant (P = 0.30). In addition, we found statistically significant genotype-dietary fat interaction on the change in total abdominal adipose tissue, visceral adipose tissue, and SAT at 24 mo (P = 0.01, 0.05, and 0.04): the rs16147 T allele appeared to associate with more adverse change in the abdominal fat deposition in the high-fat diet group than in the low-fat diet group.
  
  
  CONCLUSIONS
  Our data indicate that the NPY rs16147 genotypes affect the change in abdominal adiposity in response to dietary interventions, and the effects of the rs16147 single-nucleotide polymorphism on central obesity and abdominal fat distribution were modified by dietary fat.
authors.affiliation: Departments of Epidemiology, Department of Epidemiology, School of Public Health, Brown University, Providence, RI;
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Lin
authors.affiliation: Nutrition, and Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY;
authors.forename: Qibin
authors.initials: Q
authors.lastname: Qi
authors.affiliation: Nutrition, and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Nutrition, and.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: Departments of Human and Medical Genetics, McGill University and Québec Innovation Centre, Montréal, Canada; Fondation Jean Dausset-CEPH, Paris, France;
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.affiliation: Commissariat à l'Energie Atomique, Institut Génomique, Centre National de Génotypage, Evry, France;
authors.forename: Diana
authors.initials: D
authors.lastname: Zelenika
authors.affiliation: Pennington Biomedical Research Center of the Louisiana State University System, Baton Rouge, LA;
authors.forename: George A
authors.initials: GA
authors.lastname: Bray
authors.affiliation: Nutrition, and.
authors.forename: Frank M
authors.initials: FM
authors.lastname: Sacks
authors.affiliation: Departments of Epidemiology, Biostatistics, Harvard School of Public Health, Boston, MA; nhlqi@channing.harvard.edu lliang@hsph.harvard.edu.
authors.forename: Liming
authors.initials: L
authors.lastname: Liang
authors.affiliation: Nutrition, and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA nhlqi@channing.harvard.edu lliang@hsph.harvard.edu.
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
mesh_terms: D050153:Abdominal Fat / Q000473:pathology*; D050154:Adiposity; D000328:Adult; D015992:Body Mass Index; D018752:Diet, Fat-Restricted; D059305:Diet, High-Fat; D004038:Diet, Reducing; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D050152:Intra-Abdominal Fat; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics* / Q000378:metabolism; D056128:Obesity, Abdominal / Q000178:diet therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D050507:Subcutaneous Fat, Abdominal; D055105:Waist Circumference; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D009478:Neuropeptide Y
keywords: SNP; dietary fat; fat distribution; gene-nutrient interaction; neuropeptide Y