title: Ultrasensitive ROS-Responsive Coassemblies of Tellurium-Containing Molecules and Phospholipids.
abstract: Reactive oxygen species (ROS) play crucial roles in cell signaling and redox homeostasis and are strongly related to metabolic activities. The increase of the ROS concentration in organisms can result in several diseases, such as cardiovascular diseases and cancer. The concentration of ROS in biologically relevant conditions is typically as low as around tens of micromolars to 100 μM H2O2, which makes it necessary to develop ultrasensitive ROS-responsive systems. A general approach is reported here to fabricate an ultrasensitive ROS-responsive system via coassembly between tellurium-containing molecules and phospholipids, combining the ROS-responsiveness of tellurium and the biocompatibility of phospholipids. By using dynamic light scattering, transmission electron microscopy, scanning electron microscopy, and NMR spectra, coassembly behaviors and the responsiveness of the coassemblies have been investigated. These coassemblies can respond to 100 μM H2O2, which is a biologically relevant ROS concentration, and demonstrate reversible redox properties.
authors.affiliation: †Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: †Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.|‡The Research Centre for Molecular Science and Engineering, Northeastern University, Shenyang, 110004, People's Republic of China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Fan
authors.affiliation: †Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.affiliation: †Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Huaping
authors.initials: H
authors.lastname: Xu
mesh_terms: D008422:Materials Testing; D015336:Molecular Probe Techniques; D015335:Molecular Probes / Q000138:chemical synthesis*; D010743:Phospholipids / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000032:analysis* / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013691:Tellurium / Q000737:chemistry*
chemical_list: D015335:Molecular Probes; D010743:Phospholipids; D017382:Reactive Oxygen Species; D013691:Tellurium
keywords: coassembly; phospholipid; reactive oxygen species; tellurium; ultrasensitive