title: Characterization of Third-Generation-Cephalosporin-Resistant Shiga Toxin-Producing Strains of Escherichia coli O157:H7 in Japan.
abstract: We isolated Shiga toxin-producing Escherichia coli O157:H7 strains resistant to third-generation cephalosporins. The resistant strains harbored blaCMY-2, a plasmid-mediated AmpC β-lactamase. Genotyping of isolates revealed the possible spread of this problematic bacterium. Results suggested the importance of the investigation and surveillance of enterobacteria with plasmids harboring blaCMY-2.
authors.affiliation: Division of Bacteriology, Osaka Prefectural Institute of Public Health, Osaka, Japan kawahara@iph.pref.osaka.jp.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kawahara
authors.affiliation: Division of Bacteriology, Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Seto
authors.affiliation: Division of Bacteriology, Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Masumi
authors.initials: M
authors.lastname: Taguchi
authors.affiliation: Division of Bioresources, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan Hokkaido University, The Global Station for Zoonosis Control, Sapporo, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Nakajima
authors.affiliation: Division of Bacteriology, Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kumeda
authors.affiliation: Division of Bioresources, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan Hokkaido University, The Global Station for Zoonosis Control, Sapporo, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004927:Escherichia coli Infections / Q000382:microbiology; D019453:Escherichia coli O157 / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D005838:Genotype; D006801:Humans; D007564:Japan; D010957:Plasmids / Q000032:analysis; D022621:Shiga Toxin / Q000378:metabolism*; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D022621:Shiga Toxin