title: The Association of FTO SNP rs9939609 with Weight Gain at University.
abstract: OBJECTIVE
  We tested the hypothesis that the obesity-associated FTO SNP rs9939609 would be associated with clinically significant weight gain (≥ 5% of initial body weight) in the first year of university; a time identified as high risk for weight gain.
  
  
  METHODS
  We collected anthropometric data from university students (n = 1,411, mean age: 22.4 ± 2.5 years, 49.1% male) at the beginning and end of the academic year. DNA was analysed for FTO rs9939609. Associations of FTO genotype with BMI at baseline were analysed using ANCOVA, and with risk of 5% weight gain over follow-up with logistic regression; both analyses adjusting for age and sex. The alpha level was reduced to 0.0125 to account for multiple testing.
  
  
  RESULTS
  Using an additive model, FTO status was not associated with higher BMI at baseline (22.2 vs. 21.9 kg/m2, p = 0.059). Dropout was high but unrelated to genotype. Among the 310 (21.9%) completing follow-up, those with AT genotypes had twice the odds of ≥ 5% weight gain compared with TTs (OR = 2.05, 95% CI = 1.05-4.01, p = 0.036), but this was no longer significant after Bonferroni correction. There was a trend for AA carriers for ≥ 5% weight gain compared with TT carriers (p = 0.089), but sample size was small.
  
  
  CONCLUSIONS
  This study provides nominal evidence for the genetic susceptibility hypothesis, but findings need to be replicated.
authors.affiliation: Cancer Research UK Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, UK.
authors.forename: Susanne F
authors.initials: SF
authors.lastname: Meisel
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Beeken
authors.forename: Cornelia H M
authors.initials: CH
authors.lastname: van Jaarsveld
authors.forename: Jane
authors.initials: J
authors.lastname: Wardle
mesh_terms: D000483:Alleles; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008131:London; D008297:Male; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013223:Statistics as Topic; D015430:Weight Gain / Q000235:genetics*; D055815:Young Adult