title: [(18)F]-NHC-BF3 adducts as water stable radio-prosthetic groups for PET imaging.
abstract: The radiofluorination of N-heterocyclic carbene (NHC) boron trifluoride adducts affords novel [(18)F]-positron emission tomography probes which resist hydrolytic fluoride release. The labelling protocol relies on an (18)F-(19)F isotopic exchange reaction promoted by the Lewis acid SnCl4. Modification of the NHC backbone with a maleimide functionality provides access to a model peptide conjugate which shows no evidence of defluorination when imaged in vivo.
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA. gabbai@mail.chem.tamu.edu.
authors.forename: Kantapat
authors.initials: K
authors.lastname: Chansaenpak
authors.affiliation: Department of Radiology, Biomedical Research Imaging Center, University of North Carolina, Chapel Hill 27599, USA. ziboli@med.unc.edu.
authors.forename: Mengzhe
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Radiology, Biomedical Research Imaging Center, University of North Carolina, Chapel Hill 27599, USA. ziboli@med.unc.edu.
authors.forename: Zhanhong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA. gabbai@mail.chem.tamu.edu.
authors.forename: Rehmat
authors.initials: R
authors.lastname: Zaman
authors.affiliation: Department of Radiology, Biomedical Research Imaging Center, University of North Carolina, Chapel Hill 27599, USA. ziboli@med.unc.edu.
authors.forename: Zibo
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA. gabbai@mail.chem.tamu.edu.
authors.forename: François P
authors.initials: FP
authors.lastname: Gabbaï
mesh_terms: D001880:Boranes / Q000737:chemistry*; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling; D049268:Positron-Emission Tomography; D014867:Water / Q000737:chemistry
chemical_list: D001880:Boranes; D005462:Fluorine Radioisotopes; D014867:Water; C021274:boron trifluoride