title: Assessment of cortical and trabecular bone changes in two models of post-traumatic osteoarthritis.
abstract: Subchondral bone is thought to play a significant role in the initiation and progression of the post-traumatic osteoarthritis. The goal of this study was to document changes in tibial and femoral subchondral bone that occur as a result of two lapine models of anterior cruciate ligament injury, a modified ACL transection model and a closed-joint traumatic compressive impact model. Twelve weeks post-injury bones were scanned via micro-computed tomography. The subchondral bone of injured limbs from both models showed decreases in bone volume and bone mineral density. Surgical transection animals showed significant bone changes primarily in the medial hemijoint of femurs and tibias, while significant changes were noted in both the medial and lateral hemijoints of both bones for traumatic impact animals. It is believed that subchondral bone changes in the medial hemijoint were likely caused by compromised soft tissue structures seen in both models. Subchondral bone changes in the lateral hemijoint of traumatic impact animals are thought to be due to transmission of the compressive impact force through the joint. The joint-wide bone changes shown in the traumatic impact model were similar to clinical findings from studies investigating the progression of osteoarthritis in humans.
authors.affiliation: School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado.
authors.forename: Hannah M
authors.initials: HM
authors.lastname: Pauly
authors.affiliation: Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado.
authors.forename: Blair E
authors.initials: BE
authors.lastname: Larson
authors.affiliation: School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado.|Department of Mechanical Engineering, Colorado State University, Fort Collins, Colorado.
authors.forename: Garrett A
authors.initials: GA
authors.lastname: Coatney
authors.affiliation: Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.
authors.forename: Keith D
authors.initials: KD
authors.lastname: Button
authors.affiliation: Small Animal Clinical Sciences, College of Veterinary, Michigan State University, East Lansing, Michigan.
authors.forename: Charlie E
authors.initials: CE
authors.lastname: DeCamp
authors.affiliation: Department of Radiology, Michigan State University, East Lansing, Michigan.
authors.forename: Ryan S
authors.initials: RS
authors.lastname: Fajardo
authors.affiliation: Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.|Department of Radiology, Michigan State University, East Lansing, Michigan.
authors.forename: Roger C
authors.initials: RC
authors.lastname: Haut
authors.affiliation: School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado.|Department of Mechanical Engineering, Colorado State University, Fort Collins, Colorado.
authors.forename: Tammy L
authors.initials: TL
authors.lastname: Haut Donahue
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D006614:Hindlimb / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008592:Menisci, Tibial / Q000601:surgery; D010003:Osteoarthritis / Q000000981:diagnostic imaging*; D011817:Rabbits; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology; D055114:X-Ray Microtomography
keywords: anterior cruciate ligament; knee; micro-computed tomography; subchondral bone