title: Facile synthesis of functionalized ionic surfactant templated mesoporous silica for incorporation of poorly water-soluble drug.
abstract: The present paper reported amino group functionalized anionic surfactant templated mesoporous silica (Amino-AMS) for loading and release of poorly water-soluble drug indomethacin (IMC) and carboxyl group functionalized cationic surfactant templated mesoporous silica (Carboxyl-CMS) for loading and release of poorly water-soluble drug famotidine (FMT). Herein, Amino-AMS and Carboxyl-CMS were facilely synthesized using co-condensation method through two types of silane coupling agent. Amino-AMS was spherical nanoparticles, and Carboxyl-CMS was well-formed spherical nanosphere with a thin layer presented at the edge. Drug loading capacity was obviously enhanced when using Amino-AMS and Carboxyl-CMS as drug carriers due to the stronger hydrogen bonding force formed between surface modified carrier and drug. Amino-AMS and Carboxyl-CMS had the ability to transform crystalline state of loaded drug from crystalline phase to amorphous phase. Therefore, IMC loaded Amino-AMS presented obviously faster release than IMC because amorphous phase of IMC favored its dissolution. The application of asymmetric membrane capsule delayed FMT release significantly, and Carboxyl-CMS favored sustained release of FMT due to its long mesoporous channels and strong interaction formed between its carboxyl group and amino group of FMT.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, Shenyang 110016, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, Shenyang 110016, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, Shenyang 110016, China.
authors.forename: Baixue
authors.initials: B
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, Shenyang 110016, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, Shenyang 110016, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Bao
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, Shenyang 110016, China.
authors.forename: Weisan
authors.initials: W
authors.lastname: Pan
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, Shenyang 110016, China. Electronic address: li_sanming2013@163.com.
authors.forename: Sanming
authors.initials: S
authors.lastname: Li
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D015738:Famotidine / Q000737:chemistry; D007213:Indomethacin / Q000737:chemistry; D016062:Porosity; D011437:Propylamines; D012821:Silanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D011437:Propylamines; D012821:Silanes; D013501:Surface-Active Agents; D014867:Water; C040733:tetraethoxysilane; D015738:Famotidine; D012822:Silicon Dioxide; C477625:amino-propyl-triethoxysilane; D007213:Indomethacin
keywords: Amine modification; Carboxylic modification; Drug incorporation; Ionic surfactant template; Mesoporous silica