title: Macrophage Supply and Demand at the Core of the Necrotic Granuloma.
abstract: Central necrosis of granulomas is linked to progression of major diseases, including tuberculosis and atherosclerosis. In this issue of Cell Host & Microbe, Pagán et al. (2015) reveal that necrotic granulomas develop when macrophage supply is insufficient. These findings suggest augmenting macrophage availability as a therapeutic strategy in tuberculosis.
authors.affiliation: Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: grandolph@path.wustl.edu.
authors.forename: Gwendalyn J
authors.initials: GJ
authors.lastname: Randolph
mesh_terms: D000818:Animals; D006099:Granuloma / Q000473:pathology*; D054884:Host-Pathogen Interactions; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology*; D019910:Mycobacterium marinum / Q000254:growth & development* / Q000276:immunology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins