title: Hemophagocytic Lymphohistiocytic Syndrome and Enteropathy-Associated T-cell Lymphoma in a Patient with Refractory Celiac Disease.
abstract: A 70-year-old woman with celiac disease presented with weight loss and diarrhea unresponsive to gluten-free diet (GFD) and prednisone. Diagnosis of type 2 refractory celiac disease (RCD) was made by small intestinal biopsies showing severe villous blunting and intraepithelial lymphocytosis. She was diagnosed with hemophagocytic lymphohistiocytic syndrome (HLH) after developing fever, pancytopenia, hypofibrinogenemia, elevated ferritin, and demonstration of hemophagocytosis on her bone marrow biopsy. An expert pathologist on lymphoma reviewed her biopsies and revised the final diagnosis to type 1 enteropathy-associated T-cell lymphoma (EATL) based on large T-cells infiltrating the lamina propria. We describe the first case of HLH associated with localized EATL and RCD.
authors.affiliation: Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Lucy
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Shuoyan
authors.initials: S
authors.lastname: Ning
authors.affiliation: Harvard School of Public Health, Harvard University, Boston, MA.
authors.forename: Zain
authors.initials: Z
authors.lastname: Kassam
authors.affiliation: Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Richard
authors.initials: R
authors.lastname: Hunt
authors.affiliation: Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Marco
authors.initials: M
authors.lastname: Puglia