title: Bouquet variety of antiphospholipid antibodies in recurrent pregnancy loss.
abstract: Seventy-six female patients with two or more recurrent pregnancy losses (RPL) during the 1(st) trimester were studied. Based on the results of the aCL and aB2GPI antibodies testing, patients were divided in two groups: 22 patients with RPL and elevated immunoglobulin (Ig) G/IgM aCL and/or aB2GPI [RPL + antiphospholipid syndrome (APS)] and 54 patients with RPL alone (without high antibodies). Immunoglobulin G aPS and IgG a-AnV in patients with RPL + APS were higher than in controls and IgG aPS were higher in RPL + APS than in RPL alone. Additionally IgG a-AnV and IgM aPE are higher in RPL alone than in controls. In 18/22 (81%) patients with RPL + APS and 29/54 (54%) patients with RPL alone, there were one or more positive antibodies: aPS, aPT, a-AnV or aPE. These results raise a question whether or not these antiphospholipid antibodies should be routinely tested in women with RPL and especially in the context of the so-called "seronegative APS".
authors.affiliation: Medical University-Sofia, University Hospital Alexandrovska, Sofia, Bulgaria.
authors.forename: Marta P
authors.initials: MP
authors.lastname: Baleva
authors.affiliation: Medical University-Sofia, University Hospital Majchin Dom, Sofia, Bulgaria.
authors.forename: Zhivka P
authors.initials: ZP
authors.lastname: Karagyozova
authors.affiliation: Medical University-Sofia, University Hospital Alexandrovska, Sofia, Bulgaria.
authors.forename: Milena K
authors.initials: MK
authors.lastname: Nikolova-Vlahova
authors.affiliation: University Hospital Alexandrovska, Sofia, Bulgaria.
authors.forename: Krasimir V
authors.initials: KV
authors.lastname: Nikolov
authors.affiliation: Medical University Sofia, Sofia, Bulgaria.
authors.forename: Petar K
authors.initials: PK
authors.lastname: Nikolov
keywords: antiphospholipid antibodies; antiphospholipid syndrome; recurrent pregnancy loss