title: Prevalence and risk factors associated with colonization and infection of extensively drug-resistant Pseudomonas aeruginosa: a systematic review.
abstract: Pseudomonas aeruginosa is a Gram-negative human pathogen with extensively drug-resistant (XDR) strains emerging in hospitals across the globe. This systematic review is focused on the worldwide prevalence of XDR P. aeruginosa (XDR-PA) and on the risk factors associated with its colonization and infection, based on literature available through PubMed, Web of Science and BioMed Central databases. An overview of surveillance systems is provided as well as a synopsis on the prevalence of XDR-PA, showing an increase in recent reports. Risk factors independently associated with XDR-PA colonization or infections are described in four groups with reference to antimicrobial therapy, medical devices as well as patient- and hospital environment-related factors.
authors.affiliation: Institute of Medical Microbiology and Hygiene, University of Tübingen, Tübingen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Buhl
authors.forename: Silke
authors.initials: S
authors.lastname: Peter
authors.forename: Matthias
authors.initials: M
authors.lastname: Willmann
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015169:Colony Count, Microbial / Q000379:methods; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015995:Prevalence; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents
keywords: Pseudomonas aeruginosa; acquisition; colonization; extensive drug resistance; extensively drug-resistant; infection; prevalence; review; risk factors