title: Chemoselective N-Heterocyclic Carbene-Catalyzed Cascade of Enals with Nitroalkenes.
abstract: An unprecedented N-heterocyclic carbene catalyzed chemoselective and enantioselective cascade reaction of enals with nitroalkenes has been developed. A wide range of enantioenriched dihydrocoumarins has been prepared, and the reaction goes through an enolate intermediate generated under a catalytic process.
authors.affiliation: Department of Pharmacology and Pharmaceutical Science, School of Medicine, Tsinghua University, Beijing 117543, China.
authors.forename: Zijun
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Pharmacology and Pharmaceutical Science, School of Medicine, Tsinghua University, Beijing 117543, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmacology and Pharmaceutical Science, School of Medicine, Tsinghua University, Beijing 117543, China.
authors.forename: Fangyi
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Pharmacology and Pharmaceutical Science, School of Medicine, Tsinghua University, Beijing 117543, China.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Pharmacology and Pharmaceutical Science, School of Medicine, Tsinghua University, Beijing 117543, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D006571:Heterocyclic Compounds; D009574:Nitro Compounds; C030011:carbene; D008697:Methane