title: Clinicopathological features and survival analysis of gastroenteropancreatic neuroendocrine neoplasms: a retrospective study in a single center of China.
abstract: OBJECTIVE
  To investigate the clinicopathological features, survival and prognostic factors for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in a Chinese population.
  
  
  METHODS
  We investigated 154 consecutive patients (88 males, 66 females; median age 56 years, age range 9-86 years) diagnosed with GEP-NENs between 2001 and 2013 at The Affiliated Hospital of Qingdao University. Demographic, clinical and pathological variables and survival data were retrieved.
  
  
  RESULTS
  The pancreas was the most common site of involvement (63/154, 40.9%). Tumor size varied from 0.3 to 16.0 cm (median, 1.2 cm). The patients were followed up for a median period of 22 months (range, 1-157 months). The estimated 3- and 5-year overall survival (OS) rates for all patients were 84.0% and 81.9%, respectively. Multivariate analysis showed that larger tumor size, lymphatic metastases and distant metastases were significant predictors for poor survival outcome.
  
  
  CONCLUSIONS
  Our data provide further information on the clinicopathological features of GEP-NENs in China. Additionally, we identified tumor size, lymphatic metastases and distant metastases as independent prognostic factors for long-term survival.
authors.affiliation: 1 General Surgery Department, 2 Pathology Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 3 Department of Epidemiology and Health Statistics, The Medical College of Qingdao University, Qingdao 266003, China.
authors.forename: Xuelong
authors.initials: X
authors.lastname: Jiao
authors.affiliation: 1 General Surgery Department, 2 Pathology Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 3 Department of Epidemiology and Health Statistics, The Medical College of Qingdao University, Qingdao 266003, China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1 General Surgery Department, 2 Pathology Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 3 Department of Epidemiology and Health Statistics, The Medical College of Qingdao University, Qingdao 266003, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: 1 General Surgery Department, 2 Pathology Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 3 Department of Epidemiology and Health Statistics, The Medical College of Qingdao University, Qingdao 266003, China.
authors.forename: Shanglong
authors.initials: S
authors.lastname: Liu
authors.affiliation: 1 General Surgery Department, 2 Pathology Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 3 Department of Epidemiology and Health Statistics, The Medical College of Qingdao University, Qingdao 266003, China.
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Zhang
authors.affiliation: 1 General Surgery Department, 2 Pathology Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 3 Department of Epidemiology and Health Statistics, The Medical College of Qingdao University, Qingdao 266003, China.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Zhou
keywords: Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN); Ki-67; clinicopathological characteristics; retrospective study; survival analysis