title: Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children.
abstract: Background. Insulin induced gene 2 (INSIG2) encodes a protein that has a biological effect on regulation of adipocyte metabolism and body weight. This study aimed to investigate the association of INSIG2 gene -102G>A polymorphism with obesity related phenotypes in Chinese children and test gender-specific effects. Methods. The 2,030 independent individuals aged from 7 to 18 years, including 705 obese cases and 1,325 nonobese controls, were recruited from local schools. We measured the obesity-related phenotypes and detected the serum lipids. We genotype -102G>A polymorphism by using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Results. In all individuals, we found that the GG/GA genotype of INSIG2 -102G>A polymorphism was associated with risk of severe obesity (OR = 1.62, 95% CI: 1.11-2.36, and P = 0.012) under the dominant model. The association with severe obesity existed only in boys (OR = 1.91, 95% CI: 1.15-3.17, P = 0.012). The GG/GA genotype of -102G>A polymorphism was also associated with higher waist circumference (β = 2.61 cm, P = 0.031) in boys. No similar association was found in girls. The polymorphism was not associated with other obesity-related phenotypes, neither in all individuals nor in gender-specific population. Conclusions. This study identified a gender-specific effect of INSIG2 -102G>A polymorphism on risk of severe obesity and waist circumference in Chinese boys.
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Fang-Hong
authors.initials: FH
authors.lastname: Liu
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Jie-Yun
authors.initials: JY
authors.lastname: Song
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Zhang
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Wang