title: RNA interference technology with emphasis on delivery vehicles-prospects and limitations.
abstract: BACKGROUND
  RNA interference (RNAi)-based therapeutics rely upon safe and efficient delivery of small interfering RNA (siRNA) molecules.
  
  
  OBJECTIVE
  This review explores various dimensions of RNAi with emphasis on the development of nanoparticle-based delivery vectors for safe and efficient siRNA delivery.
  
  
  METHODS
  An exhaustive database search has been done regarding studies done to investigate the potential of siRNA delivery employing nanoparticles has been cited in the present review.
  
  
  CONCLUSIONS
  With the current challenges, there is a need for collaborative work allowing for the successful development of nanoparticle/siRNA complexes as health-promoting biotherapeutics.
authors.affiliation: a Department of Pharmaceutical Chemistry , Jamia Hamdard University , New Delhi , India.
authors.forename: Shashi
authors.initials: S
authors.lastname: Prabha
authors.affiliation: b Department of Biotechnology , The IIS University , Jaipur , India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Vyas
authors.affiliation: b Department of Biotechnology , The IIS University , Jaipur , India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Gupta
authors.affiliation: a Department of Pharmaceutical Chemistry , Jamia Hamdard University , New Delhi , India.
authors.forename: Bahar
authors.initials: B
authors.lastname: Ahmed
authors.affiliation: c Department of Chemistry , University of Delhi , Delhi , India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chandra
authors.affiliation: d Department of Biotechnology , Central University of Rajasthan, School of Life Sciences , Ajmer , India.
authors.forename: Surendra
authors.initials: S
authors.lastname: Nimesh
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000737:chemistry / Q000235:genetics; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000096:biosynthesis / Q000235:genetics
chemical_list: D034741:RNA, Small Interfering
keywords: RNA interference; gene silencing; nanoparticles; small interfering RNA; transfection