title: Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk.
abstract: OBJECTIVE
  This study was designed to evaluate the relationship among circulating adiponectin (ADPN), left ventricular mass (LVM) and cardio-metabolic comorbidities in subjects at higher global cardiovascular risk (score of"Cuore Project").
  
  
  METHODS
  115 consecutive subjects were grouped according to normal or low ADPN levels. Left ventricular internal diameter (LVID/h), total LV mass (LVM), LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated.
  
  
  RESULTS
  Low-ADPN subjects were characterized by a significantly higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, diabetes and insulin resistance, LVH, metabolic syndrome (MetS), coronary artery syndrome (CAD). BMI (P < 0.0001), WHR (P < 0.03), trigly cerides (P < 0.001), HOMA-IR (P < 0.001), LVM, LVMI, IVST and RWT (P < 0.0001) were significantly higher and HDL-C (P < 0.001) and LVEF were significantly lower in low-ADPN than in normal-ADPN subjects. LVMI correlated directly with BMI (P < 0.001), WHR (P < 0.001) MBP (P < 0.001), MetS (P < 0.001) and inversely with ADPN (P < 0.0001). Multiple regres- sion analysis indicated that ADPN was independently associated with LVMI.
  
  
  CONCLUSIONS
  ADPN might be considered a key component mediating the cross-talk between adipose tissue, cardiac cells and the vasculature. Accordingly, its routine measurement might become a new target in the management of global CV risk.
authors.forename: Tiziana Di
authors.initials: TD
authors.lastname: Chiara
authors.forename: Christiano
authors.initials: C
authors.lastname: Argano
authors.forename: Alessandra
authors.initials: A
authors.lastname: Scaglione
authors.forename: Salvatore
authors.initials: S
authors.lastname: Corrao
authors.forename: Antonio
authors.initials: A
authors.lastname: Pinto
authors.forename: Rosario
authors.initials: R
authors.lastname: Scaglione
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002306:Cardiac Volume; D002318:Cardiovascular Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013318:Stroke Volume; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D052242:Adiponectin; D015415:Biomarkers