title: Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder.
abstract: Although more than 90% systemic mastocytosis (SM) patients express gain of function mutations in the KIT receptor, recent next generation sequencing has revealed the presence of several additional genetic and epigenetic mutations in a subset of these patients, which confer poor prognosis and inferior overall survival. A clear understanding of how genetic and epigenetic mutations cooperate in regulating the tremendous heterogeneity observed in these patients will be essential for designing effective treatment strategies for this complex disease. In this review, we describe the clinical heterogeneity observed in patients with mastocytosis, the nature of relatively novel mutations identified in these patients, therapeutic strategies to target molecules downstream from activating KIT receptor and finally we speculate on potential novel strategies to interfere with the function of not only the oncogenic KIT receptor but also epigenetic mutations seen in these patients.
authors.affiliation: Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Anindya
authors.initials: A
authors.lastname: Chatterjee
authors.affiliation: Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.|Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Joydeep
authors.initials: J
authors.lastname: Ghosh
authors.affiliation: Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.|Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.|Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.|Department of Molecular Biology and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Reuben
authors.initials: R
authors.lastname: Kapur
mesh_terms: D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics; D000090205:DNA Methyltransferase 3A; D006801:Humans; D008415:Mastocytosis / Q000145:classification / Q000188:drug therapy / Q000235:genetics*; D008957:Models, Genetic; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000188:drug therapy / Q000235:genetics*; D019009:Proto-Oncogene Proteins c-kit / Q000037:antagonists & inhibitors / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D018631:ras Proteins / Q000235:genetics
chemical_list: C000717967:DNMT3A protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; D019009:Proto-Oncogene Proteins c-kit; D018631:ras Proteins
keywords: KIT mutations; alternative targets in mastocytosis; mastocytosis; myeloproliferative disorder; signaling pathways in mastocytosis