title: TGFBR1 polymorphism and risk of breast cancer in Iranian women.
abstract: Numerous epidemiological studies have evaluated the association between transforming growth factor beta receptor type 1 (TGFBR1) polymorphisms and the risk of cancer; however, the results remain inconclusive and controversial. To determine the association between breast cancer risk and the *6A polymorphism of the TGFBR1 gene, a case-control study of 280 breast cancer patients and 280 controls was performed in Iranian women. Our study demonstrates that women who carry the TGFBR1*6A allele are at lower risk of developing breast cancer. The highest protection against breast cancer was observed in 6A/6A homozygotes (OR = 0.32, p = 0.04). A lower frequency of the TGFBR1*6A allele in breast cancer patients may be an important genetic determinant that contributes to a lower risk of breast cancer in Iranian women. The results also showed that the allelic length of TGFBR1 polymorphisms had no significant association with the age at onset or the grade of disease, nor with the expression of progesterone and estrogen receptors and HER2.
authors.affiliation: Division of Genetics, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan - Iran.
authors.forename: Elahe
authors.initials: E
authors.lastname: Kamali
authors.affiliation: Radiation Oncology Department, Isfahan University of Medical Sciences, Isfahan - Iran.
authors.forename: Simin
authors.initials: S
authors.lastname: Hemmati
authors.affiliation: Division of Genetics, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan - Iran.
authors.forename: Forouzan
authors.initials: F
authors.lastname: Safari
authors.affiliation: Division of Genetics, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan - Iran.
authors.forename: Manoochehr
authors.initials: M
authors.lastname: Tavassoli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008875:Middle Aged; D011110:Polymorphism, Genetic; D065840:Protective Factors; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D018911:Trinucleotide Repeats; D055815:Young Adult
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human