title: Single-Layer WEBs: Intrasaccular Flow Disrupters for Aneurysm Treatment—Feasibility Results from a European Study.
abstract: OBJECTIVE
  The safety and efficiency of the dual-layer Woven EndoBridge (WEB) device has already been published. However, this international multicenter study sought to evaluate the safety of single-layer devices, which are the newest generation of the WEB intrasaccular flow-disrupter family. They have been designed to offer smaller-sized devices with a lower profile to optimize navigability and delivery, which may, in turn, broaden their range of use.
  
  
  METHODS
  Data from all consecutive patients treated with a single-layer WEB device, in 10 European centers from June 2013 to May 2014 were included. Clinical presentations, technical details, intra- and perioperative complications, and outcomes at discharge were recorded. Clinical and angiographic data at last follow-up were also analyzed when available.
  
  
  RESULTS
  Ninety patients with 98 WEB-treated aneurysms were included in this study. In 93 cases (95%), WEB placement was possible. Complete occlusion at the end of the procedure was obtained in 26 instances (26%). Additional treatment during the procedure (coiling and/or stent placement) was necessary in 12 cases (12.7%). Procedure-related complications occurred in 13 cases, leading to permanent neurologic deficits in 4 patients (4.4%). Early vascular imaging follow-up data were available for 44 patients (57%), with an average time interval of 3.3 months. Treatment-related morbidity and mortality rates at last follow-up were 2.2% and 1.1%, respectively.
  
  
  CONCLUSIONS
  In this study, the feasibility and safety of the single-layer WEB device was comparable with that of the double-layer. However, further studies are needed to evaluate long-term efficacies.
authors.affiliation: From the Interventional Neuroradiology NEURI Center (J.C., C.M., J.M., L.S.), Beaujon Hospital, Clichy, France Jildaz.caroff@bjn.aphp.fr.
authors.forename: J
authors.identifier: http://orcid.org/0000-0002-0029-1835
authors.initials: J
authors.lastname: Caroff
authors.affiliation: From the Interventional Neuroradiology NEURI Center (J.C., C.M., J.M., L.S.), Beaujon Hospital, Clichy, France Department of Neurosurgery (C.M.), University of Medicine and Pharmacy "Victor Babes," Timisoara, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Mihalea
authors.affiliation: Department of Neuroradiology (J.K., C.S.), Helios General Hospital, Erfurt, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Klisch
authors.affiliation: Department of Neuroradiology (J.K., C.S.), Helios General Hospital, Erfurt, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Strasilla
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology (A.B.), Klinikum Augsburg, Augsburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Berlis
authors.affiliation: MRI Department (T.P.), Leeds Teaching Hospitals National Health Service Trust, Leeds, UK.
authors.forename: T
authors.initials: T
authors.lastname: Patankar
authors.affiliation: Interventional Neuroradiology (W.W.), Ruhr University Medical Center, Bochum, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.affiliation: Departments of Radiology and Neuroradiology (D.B.), Klinikum Vest, Recklinghausen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Behme
authors.affiliation: Interventional Neuroradiology (E.A.J.), Oslo University Hospital, Oslo, Norway.
authors.forename: E A
authors.initials: EA
authors.lastname: Jacobsen
authors.affiliation: Interventional Neuroradiology (T.L.), Universitatsklinik Koeln, Köln, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Liebig
authors.affiliation: Abteilung für Diagnostische und Interventionelle Neuroradiologie (S.P.), Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Prothmann
authors.affiliation: Interventional Neuroradiology (C.C.), Centre Hospitalier Universitaire Hôpital Purpan, Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Cognard
authors.affiliation: Interventional Neuroradiology (T.F.), Klinikum Nürnberg Süd, Nürnberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Finkenzeller
authors.affiliation: From the Interventional Neuroradiology NEURI Center (J.C., C.M., J.M., L.S.), Beaujon Hospital, Clichy, France.
authors.forename: J
authors.initials: J
authors.lastname: Moret
authors.affiliation: From the Interventional Neuroradiology NEURI Center (J.C., C.M., J.M., L.S.), Beaujon Hospital, Clichy, France.
authors.forename: L
authors.initials: L
authors.lastname: Spelle
mesh_terms: D000328:Adult; D000368:Aged; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004867:Equipment Design; D004869:Equipment Safety; D005060:Europe; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome