title: Fertility-Preserving Treatments in Patients with Gynecological Cancers: Chinese Experience and Literature Review.
abstract: We conducted a retrospectively reviewed of the literature published of patients underwent fertility-preserving treatments for cervical, endometrial and ovarian cancers using the WANFANG database in Chinese. A majority were retrospective studies and case reports. With cervical cancer, radical trachelectomy(RT) in combination with pelvic lymphadenectomy could preserve the fertility of patients with early stage IA1-IB1 cancers, Tumor size≤2 cm should be emphasized as the indication of RT in considering of the higher recurrent rate in patients with tumor size>2 cm. For endometrial cancers, there is much experience on it. Given accurate pretreatment assessment, hormonal therapy is feasible management option to preserve fertility in young patients with early stage lesions that limited to the endometrium and well differentiated. High dose progestin have been applied, oral medroxyprogesterone acetate (MPA), 250-500 mg/day, megestrol acetate 160-480 mg/day. Other therapies that have been used in a limited number of cases include GnRH analog, intrauterine devices (IUDS) containing progestogen, usually combination of these therapies. All patients should be followed up by ultrasound and/or MRI evaluation, and endometrial curettage at intervals of 3 months. With ovarian cancer, in China, fertility- preserving surgery in patients with stage IA (grade G1) of epithelial ovarian tumor and patients with germ cell tumor and borderline ovarian tumor have been successfully performed.
authors.affiliation: Obstetrics and Gynecology Department, China-Japan Friendship Hospital, Beijing, China E-mail : junechunyliu@sina.com.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Liu
authors.forename: Hua-Jun
authors.initials: HJ
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Lin
authors.forename: Bin
authors.initials: B
authors.lastname: Ling
mesh_terms: D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D005833:Genital Neoplasms, Female / Q000628:therapy*; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control*; D011379:Prognosis; D015996:Survival Rate