title: An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates.
abstract: Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica platform conjugated to CuS nanoparticles with two complementary DNA sequences. CuS nanoparticles act as both gatekeepers preventing pre-release of drugs and photothermal agents for effective killing of cancer cells. This system exhibits temperature and NIR-responsive DOX release, with an additional accelerated release rate with GSH treatment. Therefore, it can act as an effective anticancer drug delivery carrier with triggered drug release and efficient anti-cancer effect in vitro after NIR irradiation.
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Sha Tin, N.T., Hong Kong SAR, China. jimyu@cuhk.edu.hk.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Yecheng
authors.initials: Y
authors.lastname: Li
authors.forename: Zexun
authors.initials: Z
authors.lastname: Jin
authors.forename: Jimmy C
authors.initials: JC
authors.lastname: Yu
authors.forename: King Ming
authors.initials: KM
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D001483:Base Sequence; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005978:Glutathione / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009841:Oligonucleotides / Q000737:chemistry; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D009841:Oligonucleotides; D003300:Copper; D004317:Doxorubicin; D004247:DNA; D005978:Glutathione; C017846:cupric sulfide