title: Effect of adjustable gastric banding on quality of life and weight loss in the Helping Evaluate Reduction in Obesity (HERO) registry study: 2 year analysis.
abstract: OBJECTIVE
  This report from the Helping Evaluate Reduction in Obesity (HERO) Study investigated weight loss, health-related quality of life (HRQOL), and factors predictive of HRQOL improvement during a 2 year period following Lap-Band AP implantation (post-LBAP).
  
  
  METHODS
  This prospective, observational study included patients with 1 and 2 year follow-up data post-LBAP (N = 585). Changes in body mass index (BMI), percentage of weight loss (%WL), excess weight loss (%EWL) and HRQOL (Impact of Weight on Quality of Life [IWQOL]-Lite measure), and differences between <30% EWL and ≥30% EWL subgroups were assessed at 1 and 2 years post-LBAP. Multiple linear regression examined association of %EWL groups with IWQOL-Lite scores controlling for age, gender, region (US vs outside US), household income, employment status, and comorbidities.
  
  
  RESULTS
  Most patients were female (80.2%) and from the US (64.8%); overall mean (SD) age was 43.6 (11.28) years and 65.8% of patients had ≥30% EWL at year 2. At 2 years post-LBAP, mean %EWL was 43.5%; %EWL was 12.4% in the <30% EWL group and 59.6% in ≥30% EWL group (P ≤ 0.0001). Changes in IWQOL total and subscores were significantly greater in ≥30% EWL versus <30% EWL patients (all P < 0.0005) at years 1 and 2; Self-Esteem and Physical subscores had the largest changes. Multiple regression analysis showed that patients with ≥30% EWL had clinically meaningful improvements in HRQOL compared with patients having <30% EWL (P ≤ 0.001). Similarly, US patients and females had a clinically significant change in IWQOL score versus their counterparts (P ≤ 0.001). Conversely, income, comorbidities and employment status were not significant predictors of change in IWQOL scores at year 2.
  
  
  CONCLUSIONS
  These results support and extend findings regarding the effectiveness of LBAP for weight loss and illustrate the importance of ≥30% EWL as a significant factor in predicting clinically significant improvement in HRQOL 1 and 2 years post-LBAP.
  
  
  BACKGROUND
  NCT00953173.
authors.affiliation: a a University of Arizona , Tucson , AZ , USA.
authors.forename: W-L
authors.initials: WL
authors.lastname: Lao
authors.forename: D C
authors.initials: DC
authors.lastname: Malone
authors.forename: E P
authors.initials: EP
authors.lastname: Armstrong
authors.forename: D
authors.initials: D
authors.lastname: Voellinger
authors.forename: S
authors.initials: S
authors.lastname: Somers
authors.forename: J
authors.initials: J
authors.lastname: Jin
authors.forename: N
authors.initials: N
authors.lastname: Dreyer
authors.forename: D
authors.initials: D
authors.lastname: Globe
mesh_terms: D000328:Adult; D005260:Female; D015391:Gastroplasty / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000523:psychology / Q000601:surgery*; D011446:Prospective Studies; D011788:Quality of Life; D012042:Registries; D015431:Weight Loss
keywords: Bariatric surgery; Gastric banding; Gender; Geographic region; Prospective registry; Quality of life; Weight loss