title: Assessment of cytokine levels and hs-CRP in bipolar I disorder before and after treatment.
abstract: We aimed to assess the relationship between cytokine levels and the severity of the manic period in medication free patients. 30 Medication free patients and 28 healthy subjects (HS) were recruited. Plasma levels of pro-inflammatory, anti-inflammatory, inflammatory cytokines, and hs-CRP levels were investigated upon hospital admission, after six weeks follow up in bipolar disease manic episode and the results were compared to HS. The severity of the manic episodes was assessed according to the Young mania rating scale. TNF-α, INF-γ, IL-6 and hs-CRP levels were significantly higher in patients with manic episode of bipolar I disorder before treatment than HS. After treatment the levels of TNF-α, INF-γ, IL-6 and hs-CRP were observed to be significantly decreased. There was no difference between the levels of anti-inflammatory cytokines in patients before or after treatment of bipolar disorder and HS. hs-CRP was observed to be the only parameter correlated with clinical response. The most significant outcome of this study is the correlation between clinical outcome and hs-CRP levels in treatment naive manic episode bipolar type I patients. hs-CRP is the most consistent indicator according to pro-inflammatory, inflammatory and anti-inflammatory cytokines, in predicting treatment outcomes.
authors.affiliation: Edirne State Hospital, Psychiatry Unit, Edirne, Turkey. Electronic address: drvesile99@yahoo.com.tr.
authors.forename: Vesile
authors.initials: V
authors.lastname: Uyanik
authors.affiliation: Trakya University Faculty of Medicine, Department of Psychiatry, Edirne, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Tuglu
authors.affiliation: Trakya University Faculty of Medicine, Department of Psychiatry, Edirne, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Gorgulu
authors.affiliation: Trakya University Faculty of Medicine, Department of Microbiology, Edirne, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Kunduracilar
authors.affiliation: Trakya University Faculty of Medicine, Department of Hematology, Edirne, Turkey.
authors.forename: Mehmet Sevki
authors.initials: MS
authors.lastname: Uyanik
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy*; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D018692:Antimanic Agents; D016207:Cytokines; D015850:Interleukin-6; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D002097:C-Reactive Protein
keywords: Acute phase; Inflammation; Manic episode; Mood disorder