title: A Lagrangian Approach for Calculating Microsphere Deposition in a One-Dimensional Lung-Airway Model.
abstract: Using the open-source software openfoam as the solver, a novel approach to calculate microsphere transport and deposition in a 1D human lung-equivalent trumpet model (TM) is presented. Specifically, for particle deposition in a nonlinear trumpetlike configuration a new radial force has been developed which, along with the regular drag force, generates particle trajectories toward the wall. The new semi-empirical force is a function of any given inlet volumetric flow rate, micron-particle diameter, and lung volume. Particle-deposition fractions (DFs) in the size range from 2 μm to 10 μm are in agreement with experimental datasets for different laminar and turbulent inhalation flow rates as well as total volumes. Typical run times on a single processor workstation to obtain actual total deposition results at comparable accuracy are 200 times less than that for an idealized whole-lung geometry (i.e., a 3D-1D model with airways up to 23rd generation in single-path only).
authors.forename: Mayank
authors.initials: M
authors.lastname: Vaish
authors.forename: Clement
authors.initials: C
authors.lastname: Kleinstreuer
mesh_terms: D000388:Air; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008863:Microspheres; D008954:Models, Biological