title: Estimated human absorbed dose of ¹⁷⁷Lu-BPAMD based on mice data: Comparison with ¹⁷⁷Lu-EDTMP.
abstract: In this work, the absorbed dose of human organs for (177)Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with (177)Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both (177)Lu-BPAMD and (177)Lu-EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, (177)Lu-BPAMD has considerable characteristics compared with (177)Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), Tehran 14155-1339, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Yousefnia
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), Tehran 14155-1339, Iran. Electronic address: szolghadri@aeoi.org.ir.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Zolghadri
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), Tehran 14155-1339, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Shanehsazzadeh
mesh_terms: D065638:Absorption, Radiation; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D003198:Computer Simulation; D004164:Diphosphonates / Q000493:pharmacokinetics*; D006573:Heterocyclic Compounds, 1-Ring / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008954:Models, Biological; D009928:Organ Specificity; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods*
chemical_list: C528502:(4-(((bis(phosphonopropyl))carbamoyl)methyl)-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl)acetic acid; D004164:Diphosphonates; D006573:Heterocyclic Compounds, 1-Ring; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D019275:Radiopharmaceuticals; C119503:lutetium ethylenediaminetetramethylene phosphonic acid
keywords: Absorbed dose; BPAMD; EDTMP; Lu-177; RADAR