title: Trabeculectomy ab interno (trabectome): yet another possibility in the treatment of uncontrolled glaucomatocyclitic crisis under systemic valganciclovir therapy?
abstract: OBJECTIVE
  To assess the outcome of trabectome surgery in the treatment of glaucomatocyclitic crisis (Posner-Schlossman syndrome) in patients with uncontrolled intraocular pressure (IOP).
  
  
  METHODS
  Trabectome surgery was performed in seven patients with diagnosed glaucomatocyclitic crisis and uncontrolled IOP where cytomegalovirus DNA was verified by polymerase chain reaction in aqueous humour samples. All patients were treated with oral valganciclovir. After surgery the patients were followed-up for 12 months.
  
  
  RESULTS
  Mean IOP before trabectome surgery was 40±10 mm Hg (range 33-58 mm Hg). The mean number of antiglaucoma medication prior to surgery was 3.1±0.4. By the end of the 12 months, IOP in all patients was reduced to normal level (13±1 mm Hg) and their antiglaucoma medication was decreased to 0.8±1.1. No recurring attack of glaucomatocyclitic crisis occurred.
  
  
  CONCLUSIONS
  In addition to oral valganciclovir therapy, trabectome surgery seems to be a reliable and effective tool for the management of glaucomatocyclitic crisis with uncontrolled IOP.
authors.affiliation: Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Pahlitzsch
authors.affiliation: Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Torun
authors.affiliation: Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Gonnermann
authors.affiliation: Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.
authors.forename: A K B
authors.initials: AK
authors.lastname: Maier
authors.affiliation: Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Pleyer
authors.affiliation: Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Bertelmann
authors.affiliation: Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Joussen
authors.affiliation: Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.
authors.forename: M K J
authors.initials: MK
authors.lastname: Klamann
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D005260:Female; D015774:Ganciclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005901:Glaucoma / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D006801:Humans; D007429:Intraocular Pressure; D015863:Iridocyclitis / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D014129:Trabecular Meshwork / Q000601:surgery; D014130:Trabeculectomy / Q000379:methods*; D000077562:Valganciclovir
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D000077562:Valganciclovir; D015774:Ganciclovir