title: Predictive factors of cytotoxic damage in radioactive iodine treatment of differentiated thyroid cancer patients.
abstract: Radioactive iodine (131I) therapy in patients suffering from differentiated thyroid cancer (DTC) is a targeted treatment commonly used for thyroid ablation and locoregional and distant metastatic spread management. Despite a significant proportion of the131I dose entering the circulation, there is currently no detailed information regarding its effect on the blood cell system. In order to assess the cytotoxic effects of131I therapy on the circulatory system, blood cell levels, thyroid-related hormones and CD45+cell cytotoxicity were estimated in blood collected from patients with DTC. The micronuclei (MN) frequency of the peripheral blood CD45+cell fraction was significantly increased after 30 days of131I therapy compared to that prior to treatment, although a strong individual variation was observed. A significantly negative correlation between MN frequency and the level of platelets and plateletcrit was observed; however, there was no such correlation with thyroid-related hormones. These resultS suggest that the correlation between MN frequency and the platelet system may serve as a biomarker of exposure and, possibly, of sensitivity in DTC patients undergoing131I therapy following thyroid and lymph node surgery.
authors.affiliation: Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Monzen
authors.affiliation: Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Mariya
authors.affiliation: Centre for Radiation Protection Research, MBW Department, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wojcik
authors.affiliation: Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.
authors.forename: Chika
authors.initials: C
authors.lastname: Kawamura
authors.affiliation: Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Nakamura
authors.affiliation: Department of Biomedical Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Chiba
authors.affiliation: Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hosoda
authors.affiliation: Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takai
keywords: cytotoxic damage; differentiated thyroid cancer; micronuclei; predictive factors; radioactive iodine therapy