title: Treatment of Leptomeningeal Carcinomatosis in a Patient With Metastatic Cholangiocarcinoma.
abstract: A 49-year-old woman with cholangiocarcinoma metastatic to the lungs presented with new-onset unrelenting headaches. A lumbar puncture revealed malignant cells consistent with leptomeningeal metastasis from her cholangiocarcinoma. Magnetic resonance imaging (MRI) of the brain revealed leptomeningeal enhancement. An intrathecal (IT) catheter was placed and IT chemotherapy was initiated with methotrexate. Her case is notable for the rarity of cholangiocarcinoma spread to the leptomeninges, the use of IT chemotherapy with cytologic and potentially symptomatic response, and a possible survival benefit in comparison to previously reported cases of leptomeningeal carcinomatosis secondary to cholangiocarcinoma.
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Ramon E A
authors.initials: RE
authors.lastname: Jacobs
authors.affiliation: Division of Hematology and Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY.
authors.forename: Katharine
authors.initials: K
authors.lastname: McNeill
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Frank M
authors.initials: FM
authors.lastname: Volpicelli
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Karin
authors.initials: K
authors.lastname: Warltier
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Iturrate
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Charles
authors.initials: C
authors.lastname: Okamura
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Nicole
authors.initials: N
authors.lastname: Adler
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Joshua
authors.initials: J
authors.lastname: Smith
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Alana
authors.initials: A
authors.lastname: Sigmund
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Aron
authors.initials: A
authors.lastname: Mednick
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Wertheimer
authors.affiliation: Department of Medicine, New York University School of Medicine, New York, NY.
authors.forename: Katherine
authors.initials: K
authors.lastname: Hochman