title: Functional disconnection between the visual cortex and the sensorimotor cortex suggests a potential mechanism for self-disorder in schizophrenia.
abstract: Self-disorder is a hallmark characteristic of schizophrenia. This deficit may stem from an inability to efficiently integrate multisensory bodily signals. Twenty-nine schizophrenia patients and thirty-one healthy controls underwent resting-state fMRI in this study. A data-driven method, functional connectivity density mapping (FCD), was used to investigate cortical functional connectivity changes in the patients. Areas with significantly different FCD were chosen to calculate functional connectivity maps. The schizophrenia patients exhibited increased local FCD in frontal areas while demonstrating decreased local FCD in the primary sensorimotor area and in the occipital lobe. The functional connectivity analysis illustrated decreased functional connectivity between visual areas and the primary sensorimotor area. These findings suggest disturbed integration in perception-motor processing, which may contribute to mapping the neural physiopathology associated with self-disorder in schizophrenia patients.
  
  
  BACKGROUND
  Chinese Clinical Trial Registry. Registration number. ChiCTR-RCS-14004878.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Science and Education, The Fourth People's Hospital Chengdu, Chengdu, China.
authors.forename: Mingjun
authors.initials: M
authors.lastname: Duan
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Qiankun
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Yongxiu
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Dong
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Weifang
authors.initials: W
authors.lastname: Cao
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: dyao@uestc.edu.cn.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: chengluo@uestc.edu.cn.
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012146:Rest; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D066191:Sensorimotor Cortex / Q000187:drug effects / Q000503:physiopathology*; D014793:Visual Cortex / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D014150:Antipsychotic Agents
keywords: Data-driven method; Primary perceptional system; Resting-state fMRI; Schizophrenia; Self-disorder