title: Salvage robot assisted radical prostatectomy: A propensity matched study of perioperative, oncological and functional outcomes.
abstract: BACKGROUND
  To report the perioperative, functional and oncological outcomes of salvage robot-assisted laparoscopic prostatectomy (s-RARP) in a propensity score-matched analysis.
  
  
  METHODS
  53 patients underwent s-RARP at our institution. Perioperative, functional and oncological outcomes were compared between propensity matched cohorts.
  
  
  RESULTS
  Patients in the s-RARP group were at significantly higher risk based on the D'Amico classification system (p = 0.010). Estimated blood loss, complication rate, hospital stay, BCR risk, persistent cancer and time to return of potency were similar between groups (full nerve spare [NS] n = 22). In the s-RARP cohort there was a higher prevalence of lymphovascular invasion (26.4% versus 13.2%; p = 0.032), time to catheter removal and a higher prevalence of anastomotic leaks in the postoperative period (34.0% vs 5.7%, p < 0.010). The hazard ratio for return to potency regardless of nerve sparing in the s-RARP group was 0.47 (95% CI 0.25-0.88). Significantly more patients undergoing primary RARP with partial nerve sparing (NS) recovered continence (p < 0.001) and potency (p = 0.043) compared to partial NS s-RARP patients. The return to continence and potency did not differ between full NS cases (n = 22; p = 0.616).
  
  
  CONCLUSIONS
  Salvage RARP patients undergoing surgery have more high risk disease. Patients should be counseled that they are more likely to demonstrate anastomotic leakage on cystogram, and prolonged catheterization times. The time to potency and continence in s-RARP undergoing partial and no NS was significantly delayed (n = 49). The proportion of patients returning to potency and continence was also lower in our s-RARP group.
authors.affiliation: Global Robotics Institute, Florida Hospital-Celebration Health, University of Central Florida College of Medicine, USA. Electronic address: anthony.simon.bates@gmail.com.
authors.forename: A S
authors.initials: AS
authors.lastname: Bates
authors.affiliation: Global Robotics Institute, Florida Hospital-Celebration Health, University of Central Florida College of Medicine, USA.
authors.forename: S
authors.initials: S
authors.lastname: Samavedi
authors.affiliation: Global Robotics Institute, Florida Hospital-Celebration Health, University of Central Florida College of Medicine, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Global Robotics Institute, Florida Hospital-Celebration Health, University of Central Florida College of Medicine, USA.
authors.forename: V
authors.initials: V
authors.lastname: Mouraviev
authors.affiliation: Department of Urology, Fondazione Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Rocco
authors.affiliation: University of Sao Paulo State Cancer Institute, Sao Paulo, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Coelho
authors.affiliation: Global Robotics Institute, Florida Hospital-Celebration Health, University of Central Florida College of Medicine, USA.
authors.forename: K
authors.initials: K
authors.lastname: Palmer
authors.affiliation: Global Robotics Institute, Florida Hospital-Celebration Health, University of Central Florida College of Medicine, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Patel
mesh_terms: D000368:Aged; D005298:Fertility / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D057216:Propensity Score; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D012371:Robotics; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome; D014554:Urination / Q000502:physiology*
keywords: Oncological outcomes; Potency; Robotic assisted radical prostatectomy; Salvage prostatectomy; Urinary incontinence