title: Analysis of gallbladder polypoid lesion size as an indication of the risk of gallbladder cancer.
abstract: OBJECTIVE
  Recent advances in ultrasonography have contributed to the early detection of gallbladder cancer. We attempted to predict the progression of the disease by comparing the sizes of polypoid lesions, and we suggest that the size of the lesion would be a useful guideline to determine an appropriate primary surgical approach for polypoid lesions of the gallbladder.
  
  
  METHODS
  We have retrospectively analyzed 253 patients that, during the operation period from January 2009 to December 2011, had had ultrasonographically detected gallbladder polypoid lesions, and who underwent cholecystectomy at Ulsan university hospital. We have analyzed the demographic data of the patients, the preoperative size of polypoid lesions, and pathologic findings.
  
  
  RESULTS
  Of a total of 253 patients, 235 patients had benign lesions, and 18 patients had malignant lesions. Among the malignant polyp patients, 11 had pT1 cancer, 6 had pT2 cancer, and 1 had pT3 cancer. The average size of polypoid lesions was 9.1±3.1 mm and that of malignant lesions was 28.2±16.4 mm. The receiver operating characteristic (ROC) curve of the benign and malignant groups shows that 14.5 mm is the optimal point of prediction of the malignancy. Of a total of 18 patients of GB cancer, 11 had pT1 and the average size of their polypoid lesions was 20.5±5.8 mm 7 had pT2 with a size of 39.1±20.7 mm. ROC curve analysis of the pT1 and pT2 groups shows that 27 mm would be the optimal point to predict T2 and above cancer.
  
  
  CONCLUSIONS
  In the case of an early cancer, curative treatment can be achieved through a simple and minimally invasive laparoscopic cholecystectomy. We attempted to predict early cancer occurrence among polypoid lesions of the gallbladder using the simplest standard, size. Although there are some limitations, size can be a simple and easy way to evaluate polypoid lesions of the gallbladder.
authors.affiliation: Department of Surgery, Ulsan University Hospital and University of Ulsan College of Medicine, Ulsan, Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Sung
authors.affiliation: Department of Surgery, Ulsan University Hospital and University of Ulsan College of Medicine, Ulsan, Korea.
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Nam
authors.affiliation: Department of Surgery, Ulsan University Hospital and University of Ulsan College of Medicine, Ulsan, Korea.
authors.forename: Yang Won
authors.initials: YW
authors.lastname: Nah
authors.affiliation: Department of Surgery, Ulsan University Hospital and University of Ulsan College of Medicine, Ulsan, Korea.
authors.forename: Byung Sung
authors.initials: BS
authors.lastname: Kim
keywords: Gallbladder; Gallbladder cancer; Polypoid lesion; Size; Stage