title: 1HMRS results of hippocampus in the patients with obsessive-compulsive disorder before and after cognitive behavioral therapy.
abstract: OBJECTIVE
  In the present study, we examined the effects of cognitive behavioral therapy (CBT) on the hippocampal neurochemistry in patients with obsessive-compulsive disorder (OCD).
  
  
  METHODS
  Twelve patients with OCD and same number of healthy controls were included into the study. Neurochemical variables of the hippocampus were measured before and after the CBT treatment in the patient group.
  
  
  RESULTS
  At baseline, the patients with OCD had significantly lower ratio of N-acetyl-l-aspartate/choline (NAA/CHO) compared with that of healthy control subjects. When comparing pre-treatment results of the patient group with those of post-treatment ones using paired t-test, we found that NAA/CHO ratio increased from 2.47 ± 0.64 to 3.66 ± 0.88, with a statisical significance.
  
  
  CONCLUSIONS
  The findings may implicate that CBT increases the level of NAA which is a marker of neuronal integrity.
authors.affiliation: a Department of Psychiatry , School of Medicine, Firat University , Elazig , Turkey.
authors.forename: Murad
authors.initials: M
authors.lastname: Atmaca
authors.affiliation: b Department of Radiology , School of Medicine, Firat University , Elazig , Turkey.
authors.forename: Hanefi
authors.initials: H
authors.lastname: Yildirim
authors.affiliation: a Department of Psychiatry , School of Medicine, Firat University , Elazig , Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: a Department of Psychiatry , School of Medicine, Firat University , Elazig , Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Caglar
authors.affiliation: a Department of Psychiatry , School of Medicine, Firat University , Elazig , Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Mermi
authors.affiliation: c Elazig Mental Health Hospital , Elazig , Turkey.
authors.forename: M Gurkan
authors.initials: MG
authors.lastname: Gurok
authors.affiliation: d Yildirim Beyazit Diskapı Educationald and Investigational Hospital , Ankara , Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Kekilli
authors.affiliation: e Department of Psychiatry , School of Medicine, Hasan Kalyoncu University , Istanbul , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Turkcapar
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism* / Q000628:therapy*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*
keywords: CBT; MRS; OCD; hippocampus