title: Brain functional plasticity at rest and during action in multiple sclerosis patients.
abstract: We aimed to demonstrate that basal functional connectivity reorganization observed in a specific network at rest using resting state functional MRI (rs-fMRI) could be associated with functional cortical reorganization in such network during action (ta-fMRI) in a population of early multiple sclerosis (MS) patients. Altered basal functional connectivity has been previously reported in patients with MS but relationships with cortical reorganization during action have not been explored. Thirteen patients with early relapsing-remitting MS and 14 matched healthy controls were explored on a 3T MRI scanner at rest and during a motor task (conjugate finger flexion and extension movements of each hand). Hand motor networks were extracted from rs-fMRI data using group spatial independent component analysis. For the non-dominant motor network, patients presented a higher basal functional connectivity at rest and recruited a supplementary prefrontal cortical area during action compared to the controls. The levels of hyperconnectivity at rest and of activation in the recruited area during action were significantly correlated. No differences were demonstrated for the dominant motor network at rest and during action. The present study, combining rs-fMRI and ta-fMRI in non-disabled patients with early MS, revealed for the first time a direct association between functional reorganization depicted at rest and during action within the same system.
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France; Sainte-Anne Military Teaching Hospital, Department of Neurology, Toulon, France. Electronic address: anthonyfa@wanadoo.fr.
authors.forename: Anthony
authors.initials: A
authors.lastname: Faivre
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France; Assistance Publique Hopitaux de Marseille, Timone University Hospital, Department of Neurology and Clinical Neurosciences, Marseille, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Rico
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France.
authors.forename: Wafaa
authors.initials: W
authors.lastname: Zaaraoui
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France; Assistance Publique Hopitaux de Marseille, Timone University Hospital, Department of Neurology and Clinical Neurosciences, Marseille, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Reuter
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France.
authors.forename: Sylviane
authors.initials: S
authors.lastname: Confort-Gouny
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France; Assistance Publique Hopitaux de Marseille, Timone University Hospital, Department of Medical Imaging, Marseille, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Guye
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France; Assistance Publique Hopitaux de Marseille, Timone University Hospital, Department of Neurology and Clinical Neurosciences, Marseille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Pelletier
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ranjeva
authors.affiliation: Aix-Marseille University, National Center for Scientific Research, Center for Magnetic Resonance in Biology and Medicine UMR 7339, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille 13385, France; Assistance Publique Hopitaux de Marseille, Timone University Hospital, Department of Neurology and Clinical Neurosciences, Marseille, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Audoin
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology*; D009473:Neuronal Plasticity; D012146:Rest / Q000502:physiology*; D055815:Young Adult
keywords: Brain plasticity; Functional MRI; Functional connectivity; Motor system; Multiple sclerosis; Resting state