title: Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients.
abstract: We hypothesized that attenuated niacin skin flushing in schizophrenia patients might be associated with polymorphic variants in PLA2G6 and PLA2G4C genes (rs4375 and rs1549637 variations) which encode calcium-independent phospholipase A2 beta (iPLA2β) and cytosolic phospholipase A2 gamma (cPLA2γ) enzymes. The iPLA2β and cPLA2γ may play an important role in niacin-mediated signaling; in addition to their major role - mediating phospholipids remodeling, which alters membrane receptors and signal transduction, they regulate the reservoir of arachidonic acid for prostaglandins synthesis. Skin response to topical niacin of 0.1M, 0.01M, 0.001M and 0.0001M concentrations in 75 schizophrenia patients was rated using the method of volumetric niacin response (VNR). Neither PLA2G6 nor PLA2G4C gene polymorphisms were significantly associated with VNR values. Furthermore, polymorphisms׳ synergy on niacin skin flushing was also not detected.
authors.affiliation: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia. Electronic address: sergej.nadalin@medri.uniri.hr.
authors.forename: S
authors.initials: S
authors.lastname: Nadalin
authors.affiliation: School of Medicine, University of Rijeka, Rijeka, Croatia.
authors.forename: I
authors.initials: I
authors.lastname: Radović
authors.affiliation: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Buretić-Tomljanović
mesh_terms: D000328:Adult; D017523:Croatia; D005260:Female; D005483:Flushing / Q000139:chemically induced* / Q000235:genetics*; D054513:Group IV Phospholipases A2 / Q000235:genetics* / Q000378:metabolism; D054522:Group VI Phospholipases A2 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000008:administration & dosage*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
chemical_list: D009525:Niacin; C472331:PLA2G4C protein, human; D054513:Group IV Phospholipases A2; D054522:Group VI Phospholipases A2; C516475:PLA2G6 protein, human
keywords: Niacin skin flush response; PLA2G4C gene polymorphism; PLA2G6 gene polymorphism; Schizophrenia