title: Synthetic Aziridines in Medicinal Chemistry: A Mini-Review.
abstract: Azaheterocyclic compounds are well-known to have diverse types of biological activity. Among them, azacyclopropanes, commonly referred as aziridines, occupy a prominent place in synthetic organic and medicinal chemistry due to its occurrence in natural resources, complexity involved in synthesis due to ring-strain, building blocks in organic synthesis, and its biological properties. Several novel compounds containing aziridine ring have been designed and synthesized recently by medicinal chemists for evaluating their biological profile. A number of compounds are reported as cysteine protease inhibitors, antibacterial, antifungal, anticancer, antileishmanial, and antimalarial agents. This review article summarizes the biological activity of such compounds. The preparation of such compounds is also described.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Botswaba, P. Bag: 0022, Gaborone, Botswana. singhgs@mopipi.ub.bw.
authors.forename: Girija S
authors.initials: GS
authors.lastname: Singh
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001388:Aziridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D055808:Drug Discovery / Q000379:methods; D005199:Fanconi Anemia / Q000188:drug therapy; D006801:Humans; D008288:Malaria / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D050257:Tubulin Modulators / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001388:Aziridines; D015853:Cysteine Proteinase Inhibitors; D050257:Tubulin Modulators