title: [Comparative Assessment of Effects of Isosorbide Dinitrate, Isosorbide-5-Mononitrate and Nicorandil on the Frequency of Angina Attacks and Vasoregulating Endothelial Function in Patients With Ischemic Heart Disease].
abstract: to compare effects of isosorbide dinitrate, isosorbide-5-mononitrate and nicorandil on frequency of angina attacks and vasoregulating endothelial function in patients with ischemic heart disease (IHD). MATERIAL AND METHODS. In 117 patients with stable II-III functional class angina we analyzed frequency of angina attacks, exercise tolerance, data of 24-hour Holter ECG monitoring and brachial artery Doppler study. RESULTS. Patients with IHD had impaired endothelium-dependent vasodilation in the form of reduced endothelial response to increase of "shear stress" during test with reactive hyperemia. Long-term therapy with isosorbide dinitrate, isosorbide-5-mononitrate, and nicorandil was associated with normalization of endothelium-dependent vasodilation of the brachial artery. This effect was more pronounced during therapy with nicorandil.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Sizova
authors.forename: N V
authors.initials: NV
authors.lastname: Kozlova
authors.forename: V L
authors.initials: VL
authors.lastname: Zakharova
authors.forename: E S
authors.initials: ES
authors.lastname: Shameeva
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D020108:Nicorandil; D018570:Risk Assessment / Q000379:methods*; D012426:Russia / Q000453:epidemiology; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D020108:Nicorandil; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate