title: [Effects of fructose on triglycerides in individuals with diabetes: a Meta-analysis of experimental trials].
abstract: OBJECTIVE
  To assess the effects of fructose on the blood triglycerides, particularly examining treatment dose, duration, and control of food in individuals with diabetes.
  
  
  METHODS
  A systematic review and Meta-analysis of experimental clinical trials were conducted to investigate the effect of isocaloric fructose exchange for carbohydrate on triglycerides, total cholesterol. MedLine, EMBASE, The Cochrane Library, CMBdisc, CNKI (1970-2014), and some related journals were searched. Heterogeneity was assessed by 2 tests and quantified by I2. Meta-analysis was conducted by RevMan 5.3.
  
  
  RESULTS
  15 reports (21 trials) met the eligibility criteria. Isocaloric fructose exchange for carbohydrate raised triglycerides under specific conditions in individuals with type 2 diabetes. A triglyceride-raising effect without heterogeneity was seen only in type 2 diabetes when the dose was ≥ 100 g fructose/d (WMD 0.17, 95% CI0.08 - 0.25, P < 0.0001). A triglyceride-raising effect with heterogeneity was seen in type 2 diabetes when the reference carbohydrate was starch (WMD 0.13, 95% CI 0.02 - 0.23 , P = 0.02).
  
  
  CONCLUSIONS
  Effect of fructose on the level of TG in type 2 diabetes patients is more sensitive than that in type 1 diabetes. The effect on triglycerides is dose dependent and depends on what kinds of carbohydrate is being exchanged with fructose.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Xiang
authors.forename: Jia
authors.initials: J
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Wang
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Yang
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism*; D005632:Fructose / Q000494:pharmacology*; D006801:Humans; D013549:Sweetening Agents / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
chemical_list: D013549:Sweetening Agents; D014280:Triglycerides; D005632:Fructose