title: Effects of estrogen intervention on the biomechanical characteristics of serum SOD, MDA, and middle cerebral artery in aged female rats.
abstract: OBJECTIVE
  This study aims to study the biological and biomechanical characteristics of the middle cerebral artery (MCA) in aged and estrogen-intervened aged rats, thereby providing biomechanical basis for clinics.
  
  
  METHODS
  Thirty 18-month-old Sprague Dawley (SD) rats, 30 18-month-old estrogen-intervened SD rats, and 30 four-month-old SD rats were studied. The estrogen-intervened rats were given estradiol benzoate on the fifth feeding day. Thirty-four days after the feeding, the serum of each rat was obtained. The radioimmunoassay was performed for the content determination of serum E2, ER, malondialdehyde (MDA), and superoxide dismutase (SOD). The tensile test was performed to evaluate the MCA of each rat.
  
  
  RESULTS
  Through the estrogen intervention, the serum contents of E2, ER, SOD, and MDA in old rats were restored to normal levels. The maximum stress, maximum strain, and elastic limit of the MCA in the aged estrogen-intervened rat group were greater than those of the non-intervened aged rat group, with a significant difference (p < 0.05). The elastic modulus in the aged estrogen-intervened rat group was less than that of the non-intervened aged rat group, with a significant difference (p < 0.05).
  
  
  CONCLUSIONS
  E2 intervention can improve the flexibility, toughness, and compliance of MCA in aged rats.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: S J
authors.initials: SJ
authors.lastname: Zhao
authors.forename: Y S
authors.initials: YS
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Yu
authors.forename: M
authors.initials: M
authors.lastname: Luo
mesh_terms: D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood* / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008315:Malondialdehyde / Q000097:blood*; D020768:Middle Cerebral Artery / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000097:blood / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood*; D059289:Vascular Stiffness / Q000187:drug effects*
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen; C074283:estradiol 3-benzoate; D004958:Estradiol; D008315:Malondialdehyde; D013482:Superoxide Dismutase