title: Prevalence of Sinusitis Detected by Magnetic Resonance Imaging in Subjects with Dementia or Alzheimer's Disease.
abstract: BACKGROUND
  It has been reported that periodontitis is associated with Alzheimer's disease. However, the association between paranasal sinusitis and Alzheimer's disease has not been studied, although olfactory dysfunction frequently precedes the progress of dementia or Alzheimer's disease.
  
  
  METHODS
  We studied 783 patients (283 men, 500 women; mean age 77.0 ± 7.9 years) who visited the Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, and 2139 control subjects who participated in a population-based study conducted by the National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA) in Japan. Sinusitis was evaluated using magnetic resonance imaging (MRI) according to the Lund-Mackay scoring system. A sinusitis score of ≥ 4 was classified as positive and a score of ≤ 3 was classified as negative.
  
  
  RESULTS
  The prevalence of positive sinusitis was 6.3% in patients with a mini-mental state examination (MMSE) score of < 24 (n = 507), and 5.7% in patients with Alzheimer's disease (n = 280). The rate of positive sinusitis was7.2% in the control group. The prevalence of sinusitis was not significantly different between normal controls and patients with dementia or Alzheimer's disease after adjustments for age and sex. The rate of positive sinusitis was higher in male than in female subjects in both groups.
  
  
  CONCLUSIONS
  The prevalence of sinusitis in patients with Alzheimer's disease or dementia was not higher than in the general population.
authors.forename: Minori
authors.initials: M
authors.lastname: Yasue
authors.forename: Saiko
authors.initials: S
authors.lastname: Sugiura
authors.forename: Yasue
authors.initials: Y
authors.lastname: Uchida
authors.forename: Hironao
authors.initials: H
authors.lastname: Otake
authors.forename: Masaaki
authors.initials: M
authors.lastname: Teranishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakurai
authors.forename: Kenji
authors.initials: K
authors.lastname: Toba
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokata
authors.forename: Fujiko
authors.initials: F
authors.lastname: Ando
authors.forename: Rei
authors.initials: R
authors.lastname: Otsuka
authors.affiliation: Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, 7-430, Morioka- cho, Obu City, 474-0038, Japan. tsutomun@med.nagoya-u.ac.jp.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012852:Sinusitis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology*