title: miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma.
abstract: MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type.
authors.affiliation: Department of Infectious Disease, Heping Hospital Attached to Changzhi Medical College, Changzhi 046000, China. Electronic address: suling_chen86@163.com.
authors.forename: Suling
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Infectious Disease, Heping Hospital Attached to Changzhi Medical College, Changzhi 046000, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Infectious Disease, Heping Hospital Attached to Changzhi Medical College, Changzhi 046000, China.
authors.forename: Haiyun
authors.initials: H
authors.lastname: Chai
authors.affiliation: Department of Infectious Disease, Heping Hospital Attached to Changzhi Medical College, Changzhi 046000, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tao
authors.affiliation: Department of Hematology, Heping Hospital Attached to Changzhi Medical College, Changzhi 046000, China.
authors.forename: Haili
authors.initials: H
authors.lastname: Wang
authors.affiliation: Central Laboratory, Heping Hospital Attached to Changzhi Medical College, Changzhi 046000, China.
authors.forename: Aifang
authors.initials: A
authors.lastname: Ji
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000502:physiology*; D058544:Class Ib Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D005260:Female; D064593:Heterografts; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000502:physiology*
chemical_list: C545730:MIRN502 microRNA, human; D035683:MicroRNAs; D058544:Class Ib Phosphatidylinositol 3-Kinase; C546760:PIK3CG protein, human
keywords: Hepatocellular carcinoma; PIK3CG; Proliferation; miR-502