title: Nanocellulose coated with various free fatty acids can adsorb fumonisin B1, and decrease its toxicity.
abstract: The aim of this study was to evaluate the adsorption and biological properties of nanocellulose coated with free fatty acids (NCCFFAs). At first, nanocellulose was synthesized by acid hydrolysis, and then separately coated with different free fatty acids (FFAs), including lauric acid, alpha linoleic acid, oleic acid, and palmitic acid. Next, the serial concentrations of NCCFFAs (1, 10, 100, and 1000 μg/mL) was separately added to fumonisin B1 (FB1) at 1000 μg/mL, and separately incubated at 37 °C for 1, 2, and 3h. Then, the percentage of adsorption was calculated. In the next experiment, the viability of mouse liver cells was measured when they exposed to serial concentrations of NCCFFAs, FFAs, and FB1. This study showed that the increase of incubation time and concentration of NCCFFAs led to increase of FB1 adsorption. Although FFAs and NCCFFAs had no remarkable toxicity, the high toxicity was observed for FB1. Importantly, the toxicity of FB1 was highly decreased, when incubated together with FFAs or NCCFFAs. These novel adsorbents, NCCFFAs, can be used together with different foodstuffs to remove FB1.
authors.affiliation: Department of Food Science, Yazd Science and Research Branch, Islamic Azad University, Yazd, Iran; Department of Food Science, Yazd Branch, Islamic Azad University, Yazd, Iran.
authors.forename: Mohammad Hossein Balal
authors.initials: MH
authors.lastname: Zadeh
authors.affiliation: Department of Food Science, Yazd Science and Research Branch, Islamic Azad University, Yazd, Iran; Department of Food Science, Yazd Branch, Islamic Azad University, Yazd, Iran. Electronic address: hshahdadi.2014@gmail.com.
authors.forename: Hossein
authors.initials: H
authors.lastname: Shahdadi
mesh_terms: D000327:Adsorption; D000818:Animals; D002482:Cellulose / Q000737:chemistry*; D005230:Fatty Acids, Nonesterified / Q000737:chemistry*; D037341:Fumonisins / Q000493:pharmacokinetics* / Q000633:toxicity; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles
chemical_list: D005230:Fatty Acids, Nonesterified; D037341:Fumonisins; C056933:fumonisin B1; D002482:Cellulose
keywords: Adsorption; Free fatty acid; Fumonisin B1; Nanocellulose; Toxicity