title: Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats.
abstract: Lamotrigine (LTG) has shown benefits in animal models of cerebral ischemia, but the mechanism involved was not fully studied. This study was carried out to examine the effects of LTG on cognitive dysfunction, β-amyloid1-42 accumulation, and tau protein hyperphosphorylation in the hippocampus of ischemic rats. Transient ischemic stroke was induced by middle cerebral artery occlusion. The Morris water maze test was used to evaluate the cognitive function of rats. We found that LTG significantly attenuated ischemia-induced cognitive deficits and decreased neuronal injury in the hippocampal CA1 zone. Moreover, LTG reduced β-amyloid1-42 and phosphorylated tau (AT8) in the hippocampus after ischemia. These results suggested that the cognition-protective effects of LTG after cerebral ischemia might involve inhibition of toxic β-amyloid accumulation and tau hyperphosphorylation in the hippocampus.
authors.affiliation: aDepartment of Pharmacy, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai bDepartment of Surgery, The Second Affiliated Hospital of Guiyang Medical University, Kaili, China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Han
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Qian
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: Daiwei
authors.initials: D
authors.lastname: Zhao
authors.forename: Guangchun
authors.initials: G
authors.lastname: Sun
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D003072:Cognition Disorders / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D000077213:Lamotrigine; D008297:Male; D010766:Phosphorylation / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014227:Triazines / Q000494:pharmacology / Q000627:therapeutic use*; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D014227:Triazines; D016875:tau Proteins; D000077213:Lamotrigine