title: Glutamatergic metabolite correlations with neuropsychological tests in first episode schizophrenia.
abstract: Increased glutamatergic metabolites have been found in first episode schizophrenia. Although abnormal neuropsychological functioning has been demonstrated to be a core feature of schizophrenia, no studies have examined glutamatergic metabolites and neuropsychological function in drug-naïve patients. The present study addressed whether higher levels of glutamatergic metabolites would be associated with poorer neuropsychological performance and social functioning in first episode patients. Glutamatergic concentration estimates were obtained from the left anterior cingulate cortex (ACC) and thalamus at baseline and 10 months after treatment in 16 patients with psychosis using 4.0 T (1)H magnetic resonance spectroscopy. A neuropsychological test battery was administered at baseline and 1 year. In the ACC, baseline glutamine was associated with performance on the Paced Auditory Serial Addition Task (PASAT). Glutamate at 10 months was associated with Wisconsin Card Sorting Test (WCST) errors and Trail-Making Test-B duration. Glutamine at 10 months was positively associated with WCST errors and negatively associated with WCST categories completed. In the thalamus, baseline glutamine was negatively associated with performance on the PASAT. Thalamic glutamate at baseline showed a trend towards a negative association with social functioning at 5 years. Glutamatergic metabolites were associated with neuropsychological test deficits and impaired social functioning at 5-year follow-up in patients with first episode psychosis, findings suggestive of an association between glutamatergic alterations on neurotoxicity early in the course of schizophrenia.
authors.affiliation: Department of Psychiatry, Western University, London, Ontario, Canada. Electronic address: kdempste@uwo.ca.
authors.forename: Kara
authors.initials: K
authors.lastname: Dempster
authors.affiliation: Department of Psychiatry, Western University, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.
authors.forename: Ross
authors.initials: R
authors.lastname: Norman
authors.affiliation: Department of Psychiatry, Western University, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada; St. Joseph's Health Care London, London, Ontario, Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Théberge
authors.affiliation: Department of Psychiatry, Western University, London, Ontario, Canada; St. Joseph's Health Care London, London, Ontario, Canada.
authors.forename: Maria
authors.initials: M
authors.lastname: Densmore
authors.affiliation: Department of Psychiatry, Western University, London, Ontario, Canada.
authors.forename: Betsy
authors.initials: B
authors.lastname: Schaefer
authors.affiliation: Department of Psychiatry, Western University, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada; St. Joseph's Health Care London, London, Ontario, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Williamson
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D018698:Glutamic Acid / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012917:Social Adjustment; D013223:Statistics as Topic; D013788:Thalamus / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D018698:Glutamic Acid
keywords: ACC; Cognition; Glutamate; MRS; Psychosis; Social functioning; Thalamus