title: Association of short-term ozone and temperature with sleep disordered breathing.
abstract: Scarce evidence suggests that ambient air pollution and temperature might play a role in incidence and severity of sleep disordered breathing (SDB). We investigated the association of short-term exposure to fine particulate matter (particles with a 50% cut-off aerodynamic diameter of 10 μm (PM10)), ozone and temperature with SDB in the general population. Between 2006 and 2008, 1773 participants (aged 50-80 years) of the Heinz Nixdorf Recall study underwent screening for SDB, as defined by the apnoea-hypopnoea index (AHI). We assessed daily exposure to PM10, ozone, temperature and humidity. We used multiple linear regression to estimate associations of daily PM10, ozone levels and temperature on the day of screening, adjusting for relative humidity, season, age, sex, body mass index, education, smoking habits, alcohol consumption and physical activity. In the study population, the mean±sd AHI was 11.2±11.4 events·h(-1). Over all seasons, an interquartile range increase in temperature (8.6°C) and ozone (39.5 µg·m(-3)) was associated with a 10.2% (95% CI 1.2-20.0%) and 10.1% (95% CI 2.0-18.9%) increase in AHI, respectively. Associations for temperature were stronger in summer, yielding a 32.4% (95% CI 0.0-75.3%) increase in AHI per 8.6°C (p-value for season-temperature interaction 0.08). We observed that AHI was not associated with PM10. This study suggests that short-term variations in ozone concentration and temperature are associated with SDB.
authors.affiliation: Dept of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University-Duisburg Essen, Essen, Germany gerhard.weinreich@ruhrlandklinik.uk-essen.de.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Weinreich
authors.affiliation: Dept of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University-Duisburg Essen, Essen, Germany.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Wessendorf
authors.affiliation: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: Noreen
authors.initials: N
authors.lastname: Pundt
authors.affiliation: IUF Leibniz Research Institute of Environmental Medicine at the University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Weinmayr
authors.affiliation: IUF Leibniz Research Institute of Environmental Medicine at the University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Hennig
authors.affiliation: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Moebus
authors.affiliation: Clinic of Cardiology, Stiftung Krankenhaus Bethanien, Moers, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Möhlenkamp
authors.affiliation: Clinic of Cardiology, West German Heart Center Essen, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
authors.affiliation: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Jöckel
authors.affiliation: Dept of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University-Duisburg Essen, Essen, Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Teschler
authors.affiliation: IUF Leibniz Research Institute of Environmental Medicine at the University of Düsseldorf, Düsseldorf, Germany Medical Faculty, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Hoffmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000397:Air Pollution / Q000009:adverse effects; D005260:Female; D005858:Germany; D006801:Humans; D006813:Humidity; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000009:adverse effects*; D052638:Particulate Matter / Q000009:adverse effects; D012621:Seasons; D012891:Sleep Apnea Syndromes / Q000453:epidemiology*; D013696:Temperature
chemical_list: D052638:Particulate Matter; D010126:Ozone