title: Is there a role for adaptive immunity in nonalcoholic steatohepatitis?
abstract: The growing diffusion of nonalcoholic fatty liver disease (NAFLD) is a consequence of the worldwide increase in the prevalence of obesity. Oxidative stress is widely recognized to play a pivotal role in NAFLD evolution to nonalcoholic steatohepatitis (NASH). Here we review recent evidence suggesting that oxidative stress-derived antigens originating within fatty livers stimulate both humoral and cellular adaptive immune responses and the possible mechanisms involved in sustaining hepatic inflammation in NASH.
authors.affiliation: Salvatore Sutti, Aastha Jindal, Stefania Bruzzì, Irene Locatelli, Cristina Bozzola, Emanuele Albano, Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University "Amedeo Avogadro" of East Piedmont, 28100 Novara, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sutti
authors.affiliation: Salvatore Sutti, Aastha Jindal, Stefania Bruzzì, Irene Locatelli, Cristina Bozzola, Emanuele Albano, Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University "Amedeo Avogadro" of East Piedmont, 28100 Novara, Italy.
authors.forename: Aastha
authors.initials: A
authors.lastname: Jindal
authors.affiliation: Salvatore Sutti, Aastha Jindal, Stefania Bruzzì, Irene Locatelli, Cristina Bozzola, Emanuele Albano, Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University "Amedeo Avogadro" of East Piedmont, 28100 Novara, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bruzzì
authors.affiliation: Salvatore Sutti, Aastha Jindal, Stefania Bruzzì, Irene Locatelli, Cristina Bozzola, Emanuele Albano, Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University "Amedeo Avogadro" of East Piedmont, 28100 Novara, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Locatelli
authors.affiliation: Salvatore Sutti, Aastha Jindal, Stefania Bruzzì, Irene Locatelli, Cristina Bozzola, Emanuele Albano, Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University "Amedeo Avogadro" of East Piedmont, 28100 Novara, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bozzola
authors.affiliation: Salvatore Sutti, Aastha Jindal, Stefania Bruzzì, Irene Locatelli, Cristina Bozzola, Emanuele Albano, Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University "Amedeo Avogadro" of East Piedmont, 28100 Novara, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Albano
keywords: Adaptive immunity; Hepatic inflammation; Liver; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis