title: Ligand-Free Pd-Catalyzed Double Carbonylation of Aryl Iodides with Amines to α-Ketoamides under Atmospheric Pressure of Carbon Monoxide and at Room Temperature.
abstract: A general Pd-catalyzed double carbonylation of aryl iodides with secondary or primary amines to produce α-ketoamides at atmospheric CO pressure has been developed. This transformation proceeds successfully even at room temperature and in the absence of any ligand and additive. A wide range of aryl iodides and amines can be coupled to the desired α-ketoamides in high yields with excellent chemoselectivities. Importantly, the current methodology has been demonstrated to be applied in the synthesis of bioactive molecules and chiral α-ketoamides.
authors.affiliation: †Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road No. 1, Nanjing 210023, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Du
authors.affiliation: †Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road No. 1, Nanjing 210023, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ruan
authors.affiliation: †Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road No. 1, Nanjing 210023, China.
authors.forename: Minghao
authors.initials: M
authors.lastname: Qi
authors.affiliation: †Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road No. 1, Nanjing 210023, China.|‡Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing 210023, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Han
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D001274:Atmospheric Pressure; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013696:Temperature
chemical_list: D000577:Amides; D000588:Amines; D007454:Iodides; D008024:Ligands; C520957:beta-ketoamide; D010165:Palladium; D002248:Carbon Monoxide