title: A Multihit Model: Colitis Lessons from the Interleukin-10-deficient Mouse.
abstract: Complex mechanisms are pulling the strings to initiate the development of inflammatory bowel disease. Current evidence indicates that an interaction of genetic susceptibilities (polymorphisms), environmental factors, and the host microbiota leads to a dysregulation of the mucosal immune system. In the past decades, the interleukin-10-deficient mouse has served as an excellent model to mirror the multifactorial nature of this disease. Here, we want to review in detail the interplay of the genetic factors, immune aspects, and especially summarize and discuss the role of the microbiota contributing to colitis development in the interleukin-10-deficient mouse model of inflammatory bowel disease as a multihit model.
authors.affiliation: Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
authors.forename: Lydia M
authors.initials: LM
authors.lastname: Keubler
authors.forename: Manuela
authors.initials: M
authors.lastname: Buettner
authors.forename: Christine
authors.initials: C
authors.lastname: Häger
authors.forename: André
authors.initials: A
authors.lastname: Bleich
mesh_terms: D000818:Animals; D003092:Colitis / Q000209:etiology* / Q000473:pathology*; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D016753:Interleukin-10 / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout
chemical_list: C556062:IL10 protein, mouse; D016753:Interleukin-10