title: Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report.
abstract: Chondromas originating from the sella turcica are rare, and the most common initial symptoms are headache and visual disturbance. We describe a case of sellar chondroma with endocrine impairment as an initial manifestation that completely resolved after surgery. A 40-year-old Japanese woman with amenorrhea and galactorrhea for the last 2 years was referred to our department of neurosurgery for the evaluation of high prolactin levels and a tumor in the sella turcica. A biochemical assessment indicated endocrine dysfunction. Magnetic resonance imaging and computed tomography indicated a tumor in the sella turcica. The patient's presentation favored the preoperative diagnosis of pituitary adenoma or Rathke's cleft cyst. However, because calcification was detected, other types of tumors, such as craniopharyngioma, meningioma, and chordoma, were also considered. Endoscopic transsphenoidal surgery was performed, and the possibility of a bony tumor was recognized. Finally, the tumor was completely removed, and the histopathological findings confirmed chondroma. The postoperative course was uneventful, and endocrine function improved. Five years after surgery, the patient is doing well without pituitary insufficiency, pituitary hormone medications, or signs of tumor recurrence. In cases of sellar chondroma, endocrine dysfunction sometimes precedes other symptoms, such as headache and visual disturbance. When examining a patient with an intrasellar tumor harboring calcification, clinicians must consider the possibility of sellar chondroma. Furthermore, to the best of our knowledge, this case is the first of sellar chondroma treated with endoscopic surgery to be reported.
authors.affiliation: Department of Neurosurgery, Nippon Medical School.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hattori
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tahara
authors.forename: Takuya
authors.initials: T
authors.lastname: Nakakuki
authors.forename: Mao
authors.initials: M
authors.lastname: Takei
authors.forename: Yudo
authors.initials: Y
authors.lastname: Ishii
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
authors.forename: Akio
authors.initials: A
authors.lastname: Morita
mesh_terms: D000328:Adult; D002812:Chondroma / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D004703:Endocrine System / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D051457:Hyaline Cartilage / Q000473:pathology; D008279:Magnetic Resonance Imaging; D012658:Sella Turcica / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*
chemical_list: D006728:Hormones