title: Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20.
abstract: Malignant gliomas are the most common malignant tumors in the central nervous system (CNS). Up to date, the prognosis of glioma is still very poor, effective therapy with less side-effect is very necessary. Herein, we identify a compound named as "331" selectively induced cell death in glioma cells but not in astrocytes. Compound 331 upregulated miR-494 and downregulated CDC20 in glioma cells but not in astrocytes. These results suggest that compound 331 could be a potential drug selectively targeting glioma cells through upregulating miR-494 and downregulating CDC20.
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: 1] Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, China [2] Aviation Medicine Research Laboratory, The General Hospital of the Air Force, Beijing, China.
authors.forename: Tianhui
authors.initials: T
authors.lastname: Niu
authors.affiliation: Laboratory of Computer-Aided Drug Design &Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
authors.forename: Haichuan
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Laboratory of Computer-Aided Drug Design &Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects; D064199:Cdc20 Proteins / Q000378:metabolism*; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D015536:Down-Regulation / Q000187:drug effects*; D005260:Female; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013882:Thiosemicarbazones / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014183:Transplantation, Heterologous; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D064199:Cdc20 Proteins; C547168:MIRN494 microRNA, human; D035683:MicroRNAs; D011725:Pyridines; D013882:Thiosemicarbazones; C000608321:thiosemicarbazone 331; C577488:CDC20 protein, human