title: Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances their Differentiation toward Osteogenic Outcomes.
abstract: Tissue scaffolds allowing the behavior of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein, the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) is described that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation toward osteogenic outcomes.
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.|Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.|Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
authors.forename: John G
authors.initials: JG
authors.lastname: Hardy
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.
authors.forename: Maria K
authors.initials: MK
authors.lastname: Villancio-Wolter
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
authors.forename: Rushi C
authors.initials: RC
authors.lastname: Sukhavasi
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Mouser
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
authors.forename: David
authors.initials: D
authors.lastname: Aguilar
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.|Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
authors.forename: Sydney A
authors.initials: SA
authors.lastname: Geissler
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Kaplan
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.|Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
authors.forename: Christine E
authors.initials: CE
authors.lastname: Schmidt
keywords: bone; conducting polymers; electrical stimulation; stem cells; tissue scaffolds