title: A novel oxidative stress marker in acute myocardial infarction; thiol/disulphide homeostasis.
abstract: BACKGROUND
  The aim of this study was to investigate a novel oxidative stress marker (thiol/disulphide homeostasis) in patients with acute myocardial infarction (AMI) and compare the results with healthy controls for the first time in literature.
  
  
  METHODS
  A total of 450 participants including 300 patients with AMI and 150 healthy individuals were included in the study. Left ventricular ejection fraction, body mass index, peak troponin I levels, triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein (HDL), native thiol, total thiol, and disulphide as well as disulphide/native thiol and disulphide/total thiol ratios were compared between the groups.
  
  
  RESULTS
  There were significant differences between AMI patients and the controls for left ventricular ejection fraction and troponin, HDL, native thiol, total thiol, and disulphide levels as well as disulphide/native thiol and disulphide/total thiol ratios (P < .05). Stepwise logistic regression model indicated that HDL (odds ratio [OR] = 0.923, P < .001) and disulphide levels (OR = 0.548, P < .001) and disulphide/total thiol ratio (OR = 0.356, P < .001) were significantly and independently related to AMI. The cutoff value of disulphide/total thiol ratio percentage on admission to predict AMI in all population was 4.3, with a sensitivity of 70% and a specificity of 69%.
  
  
  CONCLUSIONS
  Thiol/disulphide homeostasis may be used as a novel oxidative stress marker in patients with AMI because it is readily available, easily calculated, and relatively cheap. Further studies are needed to confirm the pathophysiologic role of thiol/disulphide homeostasis in AMI.
authors.affiliation: Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey. Electronic address: harunkundi@hotmail.com.
authors.forename: Harun
authors.initials: H
authors.lastname: Kundi
authors.affiliation: Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ates
authors.affiliation: Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Emrullah
authors.initials: E
authors.lastname: Kiziltunc
authors.affiliation: Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.affiliation: Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Cicekcioglu
authors.affiliation: Biochemistry Department, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Neselioglu
authors.affiliation: Biochemistry Department, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.affiliation: Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Ornek
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004220:Disulfides / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D018384:Oxidative Stress; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds