title: Brucella infection in a child with progressive familial intrahepatic cholestasis type 2 who had undergone liver transplantation.
abstract: Brucellosis is considered the most widespread zoonosis in the world. In endemic regions of brucellosis, childhood brucellosis includes up to one-third of all cases of human brucellosis. Brucellosis constitutes a public health problem in Turkey. A boy aged 12 yr who had PFIC2 had undergone deceased-donor liver transplantation in 2008 at the age of seven. The boy presented with fatigue, fever, and pain in the right leg and hip and was admitted to the hospital. Brucella melitensis grew in the blood culture, and the SAT was positive at a titer of 1:640. The patient was treated with oral doxycycline and rifampicin for eight wk. After treatment, the patient recovered and his blood cultures became negative. The patient's mother also had a high Brucella agglutination titer of 1:320 positive and was treated in the internal medicine department with spiramycin and doxycycline. Brucella infection should be suspected in liver transplant recipients with fever of unknown origin, especially in recipients who live in an endemic area.
authors.affiliation: Pediatric Infectious Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sutcu
authors.affiliation: Pediatric Infectious Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Damla
authors.initials: D
authors.lastname: Gokceer
authors.affiliation: Pediatric Infectious Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Hacer
authors.initials: H
authors.lastname: Akturk
authors.affiliation: Pediatric Infectious Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ayper
authors.initials: A
authors.lastname: Somer
authors.affiliation: Pediatric Infectious Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Selda Hancerli
authors.initials: SH
authors.lastname: Torun
authors.affiliation: Pediatric Gastroenterology Hepatology and Nutrition, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Mustafa Serdar
authors.initials: MS
authors.lastname: Cantez
authors.affiliation: Pediatric Gastroenterology Hepatology and Nutrition, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Durmaz
authors.affiliation: Pediatric Infectious Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Nuran
authors.initials: N
authors.lastname: Salman
mesh_terms: D017347:Brucella melitensis / Q000302:isolation & purification*; D002006:Brucellosis / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D002780:Cholestasis, Intrahepatic / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis*
keywords: brucellosis; child; liver transplantation