title: Hydrostable and Nitryl/Methyl-Functionalized Metal-Organic Framework for Drug Delivery and Highly Selective CO2 Adsorption.
abstract: By using a strategy of introducing hydrophobic groups to the linkers, a hydrostable MOF was constructed based on 5-nitroisophthalate and 2,2'-dimethyl-4,4'-bipyridine coligands, revealing a 3D dia topology structure with a 1D channel parallel to the c axis. TGA, PXRD, and water vapor sorption results show high thermal and water stability for the framework. The framework is very porous and possesses not only high busulfan payloads with an encapsulation efficiency up to 21.5% (17.2 wt %) but also very high CO2 selective capture compared with that of other small gases (i.e., CH4, N2, O2, CO, and H2) at 298 K based on molecular simulations due to the pore surface being populated by methyl and nitryl groups. Furthermore, in vitro MTT assays were conducted on four different cells lines with increasing concentrations of the framework, and the results showed that the framework was nontoxic (cell viability >80%) in spite of the concentrations up to 500 μg/mL.
authors.affiliation: †School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, P. R. China.
authors.forename: De-Yun
authors.initials: DY
authors.lastname: Ma
authors.affiliation: ‡State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249, P. R. China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.affiliation: †School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, P. R. China.
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Xiao
authors.affiliation: †School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Deng
authors.affiliation: †School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, P. R. China.
authors.forename: Pei-Feng
authors.initials: PF
authors.lastname: Lin
authors.affiliation: †School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, P. R. China.
authors.forename: Rui-Qun
authors.initials: RQ
authors.lastname: Chen
authors.affiliation: †School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, P. R. China.
authors.forename: Yun-Qiu
authors.initials: YQ
authors.lastname: Liang
authors.affiliation: †School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, P. R. China.
authors.forename: Hai-Fu
authors.initials: HF
authors.lastname: Guo
authors.affiliation: ‡State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249, P. R. China.
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.affiliation: §Guangdong Medical College, School of Pharmacy, Dongguan, 523808, P. R. China.
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D002066:Busulfan / Q000008:administration & dosage; D002245:Carbon Dioxide / Q000302:isolation & purification*; D002470:Cell Survival; D018360:Crystallography, X-Ray; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D009573:Nitrites / Q000737:chemistry* / Q000633:toxicity; D009942:Organometallic Compounds / Q000737:chemistry* / Q000633:toxicity; D010795:Phthalic Acids / Q000737:chemistry* / Q000633:toxicity; D016062:Porosity; D011725:Pyridines / Q000737:chemistry* / Q000633:toxicity
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004337:Drug Carriers; D009573:Nitrites; D009942:Organometallic Compounds; D010795:Phthalic Acids; D011725:Pyridines; C059768:isophthalate; D002245:Carbon Dioxide; D002066:Busulfan; C034306:4,4'-bipyridyl