title: Divergent Synthesis of Imidazoles and Quinazolines via Pd(OAc)2-Catalyzed Annulation of N-Allylamidines.
abstract: A Pd(OAc)2-catalyzed divergent synthesis of multisubstituted imidazoles and quinazolines from N-allylamidines has been developed. In the presence of oxidant O2 from air and/or a ligand and Pd(OAc)2, imidazoles were obtained. Nonetheless, under microwave (MW) irradiation in a sealed system, quinazolines as major products were produced.
authors.affiliation: †Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: †Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Hongxian
authors.initials: H
authors.lastname: Li
authors.affiliation: †Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Ziyang
authors.initials: Z
authors.lastname: Liao
authors.affiliation: †Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Kaiyan
authors.initials: K
authors.lastname: Lou
authors.affiliation: †Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Hexin
authors.initials: H
authors.lastname: Xie
authors.affiliation: †Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: †Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.|‡Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, United States.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000578:Amidines / Q000737:chemistry*; D002384:Catalysis; D007093:Imidazoles / Q000138:chemical synthesis; D008872:Microwaves; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000085:Acetates; D000578:Amidines; D007093:Imidazoles; D009942:Organometallic Compounds; D011799:Quinazolines; C516071:palladium(II) acetate