title: Effect of non-surgical periodontal treatment on glycemic control of patients with diabetes: a meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  The present study aimed at investigating whether non-surgical periodontal treatment can reduce the Haemoglobin A1c (HbA1c) % level in type 2 diabetic patients.
  
  
  METHODS
  A search of the literature on English publications was performed in Cochrane Central, Medline, ISI Web of Knowledge and EMBASE (until 06 February 2014). An RCT was selected if the subject was type 2 diabetic patients diagnosed with chronic periodontitis, and compared HbA1c% change after non-surgical periodontal treatment alone for at least three months of the study duration. Weighted mean difference for pooled data and large sample size strata were calculated. Heterogeneity and publication bias were explored.
  
  
  RESULTS
  After the study selection process, only 9 RCTs were suitable. Compared to the control group, the pooled analysis (n=1082) showed -0.27% (95% CI:-0.46% to -0.07%, p = 0.007) absolute difference in HbA1c % with treatment while studies with sufficient sample size had HbA1c% change of -0.014% (95% CI:-0.18% to 0.16%, p = 0.87). Publication bias was marginally significant with Egger's teat (p=0.045) but not with Begg's test (p=0.72).
  
  
  CONCLUSIONS
  The moderate reduction in HbA1c after the non-surgical therapy in patients with type 2 diabetes is consistent with previous systematic reviews. However, more large scale and high-quality RCTs are necessitated to confirm these results.
authors.affiliation: Center of Stomatology, the Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Soochow, 215004, P. R. China. liquan84@163.com.
authors.forename: Quan
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Integrated Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. haosha717@sina.com.|Department of Medical Oncology, JingmenTraditional Chinese Medicine Hospital, Jingmen, 448000, China. haosha717@sina.com.
authors.forename: Sha
authors.initials: S
authors.lastname: Hao
authors.affiliation: Center of Stomatology, the Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Soochow, 215004, P. R. China. fannyjie@126.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Stomatology, the First Affiliated Hospital of Wenzhou Medical College, No.2 Fuxue Road, Wenzhou, China. xiejingdentist@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Cardiology, the People's Hospital of Jingmen, Jingmen, 448000, China. 40987082@qq.com.
authors.forename: Xiang-Hui
authors.initials: XH
authors.lastname: Kong
authors.affiliation: Center of Stomatology, the Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Soochow, 215004, P. R. China. yangjx13@163.com.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Yang
mesh_terms: D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D016009:Chi-Square Distribution; D055113:Chronic Periodontitis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D003777:Dental Prophylaxis; D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012307:Risk Factors; D016745:Root Planing; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human