title: Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners.
abstract: BACKGROUND
  Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners.
  
  
  METHODS
  Eighteen male middle-distance runners in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, Coenzyme Q10: 5mg/kg/day) and placebo group (n= 9, Dextrose: 5mg/kg/day). After acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). Blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. Lactate, serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and creatine kinase (CK) were analyzed. Repeated ANOVA and Bonferuni as a post hoc tests were used to determine the changes in four stages. Differences between groups were determined by t-test.
  
  
  RESULTS
  The results showed that acute and short-term Coenzyme Q10 supplementation had not significant effect on basal parameters. The acute coenzyme Q10 supplementation attenuated only the exercise-induced increase in response of the plasma CRP. The short-term (14-day) coenzyme Q10 supplementation attenuated the exercise-induced increase in response of the lactate, serum interleukin- 6, tumor necrosis factor-alpha, and CRP in male middle-distance runners. However, the acute and short-term coenzyme Q10 supplementation had not any significant effect on the exerciseinduced increase response of total serum creatine kinase.
  
  
  CONCLUSIONS
  Based on the present results, it can be concluded that the 14-day coenzyme Q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, inflammatory and biochemical parameters. Therefore, short-term coenzyme Q10 supplementation is recommended to reduce exercise-induced adverse consequences.
authors.affiliation: PhD Student of Exercise Physiology, Exercise Physiology Department, University of Tabriz, Tabriz, Iran. Mostafaarmanfar@yahoo.com or marmanfar@tabrizu.ac.ir.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Armanfar
authors.affiliation: Associate Professor of Sport Physiology, Department of Physical Education, University of Tabriz, Tabriz, Iran. ajafari.@tabrizu.ac.ir.
authors.forename: Afshar
authors.initials: A
authors.lastname: Jafari
authors.affiliation: Associate Professor of Biochemistry, Department of Biochemistry, University of Tabriz, Tabriz, Iran. dehghan2001.d@yahoo.com.
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Dehghan
authors.affiliation: Department of Sport Physiology, Faculty of physical education and sport sciences, Islamic Azad University, Karaj, Iran. L.Abdizadeh@yahoo.com.
authors.forename: Leila
authors.initials: L
authors.lastname: Abdizadeh
keywords: Coenzyme Q10; Inflammatory; Lactate; Muscle damage; Runners