title: Phosphodiesterase 5 Inhibitor Use in Men With Hypertrophic Cardiomyopathy.
abstract: The prevalence of sexual dysfunction (SD) in men with hypertrophic cardiomyopathy (HC) remains unknown, yet its clinical relevance may be high given that its treatment-phosphodiesterase 5 inhibitors (PDE5i)-can increase the left ventricular outflow tract pressure gradient. In this retrospective study, we evaluated the medical records of consecutively seen men with HC for the evidence of SD (defined as SD diagnosis noted in the medical record, the use of medications unique for SD, or SD reported by the patient on a routine clinical questionnaire). Of the 283 consecutively seen men with HC (mean age 52.9 ± 14.1 years), 63 patients (22%) with SD were identified. Of those with SD, 38% were recorded as regularly using PDE5i. In conclusion, SD and the use of PDE5i present a relatively common occurrence in men with HC, and further studies are needed to develop an evidence-guided algorithm for safe implementation of SD therapies in this most common inherited cardiomyopathy.
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic; Department of Anesthesiology and Intensive Care, St. Anne's University Hospital Brno, Brno, Czech Republic.
authors.forename: Lukas
authors.initials: L
authors.lastname: Ruzek
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. Electronic address: tomkony@hotmail.com.
authors.forename: Tomas
authors.initials: T
authors.lastname: Konecny
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
authors.forename: Filip
authors.initials: F
authors.lastname: Soucek
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
authors.forename: Dana
authors.initials: D
authors.lastname: Konecny
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
authors.forename: Lukas
authors.initials: L
authors.lastname: Mach
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Steve R
authors.initials: SR
authors.lastname: Ommen
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Kopecky
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Rick A
authors.initials: RA
authors.lastname: Nishimura
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy* / Q000453:epidemiology*
chemical_list: D000319:Adrenergic beta-Antagonists; D058986:Phosphodiesterase 5 Inhibitors