title: ACETYLCHOLINESTERASE INHIBITION ACTIVITY OF SOME QUINOLINYL SUBSTITUTED TRIAZOLOTHIADIAZOLE DERIVATIVES.
abstract: A series of aralkanoic acids was converted into aralkanoic acid hydrazides through their esters formation. The aralkanoic acid hydrazides upon treatment with carbon disulfide and methanolic potassium hydroxide yielded potassium dithiocarbazinate salts, which on refluxing with aqueous hydrazine hydrate yielded 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles. The target compounds, 3-aralkyl-6-(substitutedquinolinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles, were synthesized by condensing various quinolinyl substituted carboxylic acids with 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles in phosphorus oxychloride. The structures of the newly synthesized triazolothiadiazoles were characterized by IR, 1H NMR, 13C NMR, and elemental analysis studies. The structure of one of the 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles was unambiguously deduced by single crystal X-ray diffraction analysis. All the synthesized compounds were screened for their acetylcholinesterase inhibition activities. Four of the triazolothiadiazoles exhibited excellent acetylcholinesterase inhibition activities as compared to the reference inhibitor.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Rafiq
authors.forename: Qamar
authors.initials: Q
authors.lastname: Abbas
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saleem
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanif
authors.forename: Ki Hwan
authors.initials: KH
authors.lastname: Lee
authors.forename: Sung-Yum
authors.initials: SY
authors.lastname: Seo
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D058990:Molecular Targeted Therapy
chemical_list: D002800:Cholinesterase Inhibitors; D006912:Hydroxyquinolines; D000110:Acetylcholinesterase