title: In vitro and in vivo model systems used in prostate cancer research.
abstract: New incidence of prostate cancer is a major public health issue in the Western world, and has been rising in other areas of the globe in recent years. In an effort to understanding the molecular pathogenesis of this disease, numerous cell models have been developed, arising mostly from patient biopsies. The introduction of the genetically engineered mouse in biomedical research has allowed the development of murine models that allow for the investigation of tumorigenic and metastatic processes. Current challenges to the field include lack of an animal model that faithfully recapitulates bone metastasis of prostate cancer.
authors.affiliation: Department of Structural & Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Cunningham
authors.affiliation: Department of Structural & Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA, USA ; Department of Orthopaedic Surgery, Tulane University Health Sciences Center, New Orleans, LA, USA ; Tulane Cancer Center and Louisiana Cancer Research Consortium, Tulane University Health Sciences Center, New Orleans, LA, USA ; Tulane Center for Stem Cell Research and Regenerative Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA ; Tulane Center for Aging, Tulane University Health Sciences Center, New Orleans, LA, USA.
authors.forename: Zongbing
authors.initials: Z
authors.lastname: You
keywords: cell lines; intratibial injection; mouse models; prostate cancer; xenograft