title: Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes.
abstract: Nucleoside antibiotics constitute an important family of microbial natural products bearing diverse bioactivities and unusual structural features. Their biosynthetic logics are unique with involvement of complex multi-enzymatic reactions leading to the intricate molecules from simple building blocks. Understanding how nature builds this family of antibiotics in post-genomic era sets the stage for rational enhancement of their production, and also paves the way for targeted persuasion of the cell factories to make artificial designer nucleoside drugs and leads via synthetic biology approaches. In this review, we discuss the recent progress and perspectives on the natural and engineered biosynthesis of nucleoside antibiotics.
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan university, Wuhan, 430071, China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Chen
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan university, Wuhan, 430071, China.
authors.forename: Jianzhao
authors.initials: J
authors.lastname: Qi
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan university, Wuhan, 430071, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Wu
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan university, Wuhan, 430071, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wan
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan university, Wuhan, 430071, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan university, Wuhan, 430071, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Feng
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan university, Wuhan, 430071, China. zxdeng@sjtu.edu.cn.|State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China. zxdeng@sjtu.edu.cn.
authors.forename: Zixin
authors.initials: Z
authors.lastname: Deng
mesh_terms: D039903:Actinobacteria / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D060847:Metabolic Engineering; D009705:Nucleosides / Q000096:biosynthesis* / Q000737:chemistry; D058615:Synthetic Biology
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D009705:Nucleosides
keywords: Natural products; Nucleoside antibiotics; Post-genomic era; Synthetic biology