title: Effects of Xingbi gel on leukotriene E4 and immunoglobulin E production and nasal eosinophilia in a guinea pig model for allergic rhinitis.
abstract: BACKGROUND
  Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal airways.Many therapies do not have immediate effects,even which have side-effects.However,the effects of Xingbi gel for the treatment of AR was investigated.
  
  
  OBJECTIVE
  We investigated the effects of Xingbi gel on serum levels of leukotriene E4 (LTE4) and immunoglobulin E (IgE), as well as eosinophil counts in the nasal mucosa using a guinea pig model of allergic rhinitis (AR).
  
  
  METHODS
  In addition to a healthy control group without AR, guinea pigs with AR were randomly divided into untreated AR control group, low-dose Xingbi gel (0.2483 g/mL) group, high-dose Xingbi gel (0.4966 g/mL) group, and budesonide group.
  
  
  RESULTS
  Compared to the healthy controls, untreated AR guinea pigs had significantly higher ethology scores, serum LTE4 and IgE levels, and nasal mucosa eosinophil counts (p <0.01). Treatments with low-dose Xingbi gel, high-dose Xingbi gel, and budesonide significantly reduced the ethology scores, serum LTE4 and IgE levels, and nasal mucosa eosinophil counts as compared to untreated AR model guinea pigs (p <0.01).
  
  
  CONCLUSIONS
  Xingbi gel alleviates AR in part through inhibiting LTE4 and IgE production and reducing eosinophilia in the nasal mucosa.
authors.affiliation: Fujian University of Traditional Chinese Medicine, Huatuo Road No. 1 Minhou County, Fuzhou 350122, China.
authors.forename: Si
authors.initials: S
authors.lastname: Ai
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.forename: Ke-Dan
authors.initials: KD
authors.lastname: Chu
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Zhang
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D019819:Budesonide / Q000494:pharmacology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D004802:Eosinophilia / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D005782:Gels; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D017999:Leukotriene E4 / Q000097:blood* / Q000276:immunology; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D065631:Rhinitis, Allergic / Q000097:blood / Q000188:drug therapy* / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D005782:Gels; C000613610:xingbi; D007073:Immunoglobulin E; D019819:Budesonide; D017999:Leukotriene E4