title: Abnormal cerebral functional connectivity in esophageal cancer patients with theory of mind deficits in resting state.
abstract: OBJECTIVE
  To explore the function of the default mode network (DMN) in the psychopathological mechanisms of theory of mind deficits in patients with an esophageal cancer concomitant with depression in resting the state.
  
  
  METHODS
  Twenty-five cases of esophageal cancer with theory of mind deficits (test group) that meet the diagnostic criteria of esophageal cancer and neuropsychological tests, including Beck depression inventory, reading the mind in the eyes, and Faux pas, were included, Another 25 cases of esophageal cancer patients but without theory of mind deficits (control group) were enrolled. Each patient completed a resting-state functional magnetic resonance imaging.
  
  
  RESULTS
  The functional connectivity intensities within the cerebral regions in the DMN of all the enrolled patients were analyzed. The results of each group were compared. The functional connectivity of the bilateral prefrontal central region with the precuneus, bilateral posterior cingulate gyrus and bilateral ventral anterior cingulate gyrus in the patients of the test group were all reduced significantly (P < 0.05). In the resting state, the functional connectivity is abnormal in the cerebral regions in the DMN of esophageal cancer patients with theory of mind deficits.
  
  
  CONCLUSIONS
  The theory of mind deficits might have an important function in the pathogenesis of esophageal cancer.
authors.forename: Yin
authors.initials: Y
authors.lastname: Cao
authors.forename: JianBo
authors.initials: J
authors.lastname: Xiang
authors.forename: Nong
authors.initials: N
authors.lastname: Qian
authors.forename: SuPing
authors.initials: S
authors.lastname: Sun
authors.forename: LiJun
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Psychology, The Affiliated Zhongda Hospital of Southeast University, Nanjing 210000, China.
authors.forename: YongGui
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D003863:Depression / Q000523:psychology; D004938:Esophageal Neoplasms / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012146:Rest / Q000523:psychology*; D056345:Theory of Mind / Q000502:physiology*