title: Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine spongeStellettasp.
abstract: Two new HIV-inhibitory depsipeptides, stellettapeptins A (1) and B (2), were isolated from an extract of the marine spongeStellettasp., collected from northwestern Australia. Structures of these cyclic nonribosomal peptides were elucidated on the basis of extensive NMR data analysis, and chemical degradation and derivatization studies. Stellettapeptins contain numerous nonproteinogenic amino acid residues and they are the first peptides reported to contain a 3-hydroxy-6,8-dimethylnon-4-(Z)-enoic acid moiety. Compounds1and2potently inhibit infection of human T-lymphoblastoid cells by HIV-1RFwith EC50values of 23 and 27 nM, respectively.
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Building 562, Room 201, Frederick, MD 21702-1201, USA.
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Building 562, Room 201, Frederick, MD 21702-1201, USA.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Rashid
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Building 562, Room 201, Frederick, MD 21702-1201, USA ; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702-1201, USA.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Cartner
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Building 562, Room 201, Frederick, MD 21702-1201, USA ; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702-1201, USA.
authors.forename: Heidi R
authors.initials: HR
authors.lastname: Bokesch
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Building 562, Room 201, Frederick, MD 21702-1201, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Wilson
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Building 562, Room 201, Frederick, MD 21702-1201, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: McMahon
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Building 562, Room 201, Frederick, MD 21702-1201, USA.
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Gustafson
keywords: Anti-HIV; Depsipeptide; Sponge peptide; Stelletta