title: Comparison of Acute Health Effects From Exposures to Diesel and Biodiesel Fuel Emissions.
abstract: OBJECTIVE
  To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions.
  
  
  METHODS
  We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting-lung function, lung and systemic inflammation, novel biomarkers of exposure, and oxidative stress were assessed.
  
  
  RESULTS
  B75 reduced respirable diesel particulate matter by 20%. Lung function declined significantly more after exposure to diesel emissions. Lung inflammatory cells along with sputum and plasma inflammatory mediators increased significantly to similar levels with both exposures. Urinary 8-hydroxydeoxyguanosine, a marker of oxidative stress, was not significantly changed after either exposure.
  
  
  CONCLUSIONS
  Use of B75 lowered respirable diesel particulate matter exposure and some associated acute health effects, although lung and systemic inflammation were not reduced compared with diesel use.
authors.affiliation: From the Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson.
authors.forename: Aaron A
authors.initials: AA
authors.lastname: Mehus
authors.forename: Rustin J
authors.initials: RJ
authors.lastname: Reed
authors.forename: Vivien S T
authors.initials: VS
authors.lastname: Lee
authors.forename: Sally R
authors.initials: SR
authors.lastname: Littau
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Hu
authors.forename: Eric A
authors.initials: EA
authors.lastname: Lutz
authors.forename: Jefferey L
authors.initials: JL
authors.lastname: Burgess
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis; D056804:Biofuels; D015415:Biomarkers / Q000032:analysis; D023381:Endpoint Determination; D004784:Environmental Monitoring; D005260:Female; D005742:Gasoline; D064368:Healthy Volunteers; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008297:Male; D008906:Mining; D016273:Occupational Exposure / Q000032:analysis*; D018384:Oxidative Stress; D052638:Particulate Matter / Q000032:analysis*; D012129:Respiratory Function Tests; D001335:Vehicle Emissions / Q000032:analysis*
chemical_list: D000395:Air Pollutants, Occupational; D056804:Biofuels; D015415:Biomarkers; D005742:Gasoline; D052638:Particulate Matter; D001335:Vehicle Emissions