title: Mucosal lichenoid drug reaction associated with glimepiride: a case report.
abstract: We report the case of a 52-year-old man with type 2 diabetes, who developed severe mucosal erosions of the tongue, glans penis and perianal area, induced by glimepiride. A tissue biopsy was performed and revealed the characteristics of lichen planus (LP). The improvement of the patient's condition after withdrawal of glimepiride added to recurrence of the lesions when medication was reintroduced confirmed that the second generation anti-diabetic was the causative agent. To the best of our knowledge, this has not been reported previously.
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Sfax, Sfax, Tunisia. hammamj_serria@yahoo.fr.
authors.forename: S
authors.initials: S
authors.lastname: Hammami
authors.forename: K
authors.initials: K
authors.lastname: Ksouda
authors.forename: H
authors.initials: H
authors.lastname: Affes
authors.forename: Z
authors.initials: Z
authors.lastname: Sahnoun
authors.forename: K
authors.initials: K
authors.lastname: Zeghal
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy; D003875:Drug Eruptions / Q000175:diagnosis; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D017512:Lichenoid Eruptions / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000009:adverse effects*; D014059:Tongue / Q000473:pathology
chemical_list: D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; C057619:glimepiride