title: Allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndrome: Experience of the Argentinean Group of Bone Marrow Transplantation (GATMO).
abstract: BACKGROUND
  Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative approach for patients with myelodysplastic syndrome (MDS).
  
  
  METHODS
  In this multicenter retrospective study, we analyzed the outcome of adult patients with MDS who underwent AHSCT in Argentina and evaluated the prognostic factors associated with progression-free survival (PFS), overall survival (OS), cumulative incidence (CI) of relapse, and non-relapse mortality (NRM).
  
  
  RESULTS
  We analyzed data from 87 adults (median age: 43 years, range 18-66) who underwent SCT after myeloablative (n = 60) or non-myeloablative conditioning (n = 27), and from related (n = 62) or unrelated (n = 25) donors. For all patients, unadjusted 4-year PFS and OS were 37% and 38%, respectively; no significant differences were found between recipients of related or unrelated donors. One-year CI of relapse and NRM were 21% and 20%, respectively. In the multivariate analysis, intermediate disease risk index (DRI) and acute graft versus host disease AGVHD of all grades (I-IV) were independent variables associated with better PFS and lower relapse CI; only intermediate DRI was associated with better OS.
  
  
  CONCLUSIONS
  AHSCT is a feasible procedure in Argentina, with more than 30% of the patients achieving long-term survival. Recipients with unrelated donors had at least similar outcome than those with related donors. DRI may be useful to identify patients at higher risk of relapse after transplantation.
authors.affiliation: a Hospital Privado Centro Médico de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC) , Córdoba , Argentina.
authors.forename: Ana L
authors.initials: AL
authors.lastname: Basquiera
authors.affiliation: b Hospital Universitario Austral , Pilar, Buenos Aires , Argentina.
authors.forename: María M
authors.initials: MM
authors.lastname: Rivas
authors.affiliation: c FUNDALEU , Buenos Aires , Argentina.
authors.forename: Guillermina
authors.initials: G
authors.lastname: Remaggi
authors.affiliation: d Hospital Rossi , La Plata , Argentina.
authors.forename: Graciela
authors.initials: G
authors.lastname: Klein
authors.affiliation: e Hospital Alemán , Buenos Aires , Argentina.
authors.forename: Vera
authors.initials: V
authors.lastname: Milovic
authors.affiliation: f Instituto Alexander Fleming , Buenos Aires , Argentina.
authors.forename: M Cecilia
authors.initials: MC
authors.lastname: Foncuberta
authors.affiliation: d Hospital Rossi , La Plata , Argentina.
authors.forename: Silvia
authors.initials: S
authors.lastname: Saba
authors.affiliation: g Hospital Italiano de La Plata , La Plata , Argentina.
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Milone
authors.affiliation: h Hospital Italiano de Buenos Aires , Buenos Aires , Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Arbelbide
authors.affiliation: i CEHT, Fundación Favaloro , Buenos Aires , Argentina.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Jaimovich
authors.affiliation: c FUNDALEU , Buenos Aires , Argentina.
authors.forename: Juliana Martínez
authors.initials: JM
authors.lastname: Rolón
authors.affiliation: b Hospital Universitario Austral , Pilar, Buenos Aires , Argentina.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Kusminsky
authors.affiliation: a Hospital Privado Centro Médico de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC) , Córdoba , Argentina.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: García
authors.affiliation: g Hospital Italiano de La Plata , La Plata , Argentina.
authors.forename: María V
authors.initials: MV
authors.lastname: Prates
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts; D001118:Argentina / Q000453:epidemiology; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000401:mortality* / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Disease risk index; Myelodysplastic syndrome; Relapse; Stem cell transplantation; Survival; Unrelated donors