title: radir package: an R implementation for cytogenetic biodosimetry dose estimation.
abstract: The Bayesian framework has been shown to be very useful in cytogenetic dose estimation. This approach allows description of the probability of an event in terms of previous knowledge, e.g. its expectation and/or its uncertainty. A new R package entitled radir (radiation inverse regression) has been implemented with the aim of reproducing a recent Bayesian-type dose estimation methodology. radir adopts the method of dose estimation under the Poisson assumption of the responses (the chromosomal aberrations counts) for the required dose-response curve (typically linear or quadratic). The individual commands are described in detail and relevant examples of the use of the methods and the corresponding radir software tools are given. The suitability of this methodology is highlighted and its application encouraged by providing a user-friendly command-type software interface within the R statistical software (version 3.1.1 or higher), which includes a complete manual.
authors.affiliation: Centre for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra (UPF), CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain. Unitat de Fonaments de l'Anàlisi Econòmica, Departament d'Economia i Història Econòmica, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Moriña
authors.forename: Manuel
authors.initials: M
authors.lastname: Higueras
authors.forename: Pedro
authors.initials: P
authors.lastname: Puig
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Ainsbury
authors.forename: Kai
authors.initials: K
authors.lastname: Rothkamm
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D002869:Chromosome Aberrations / Q000528:radiation effects*; D002877:Chromosomes, Human / Q000528:radiation effects*; D020732:Cytogenetic Analysis / Q000379:methods*; D006801:Humans; D016012:Poisson Distribution; D011336:Probability; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D012984:Software