title: Application of BNCT to the treatment of HER2+ breast cancer recurrences: Research and developments in Argentina.
abstract: In the frame of the Argentine BNCT Project a new research line has been started to study the application of BNCT to the treatment of locoregional recurrences of HER2+ breast cancer subtype. Based on former studies, the strategy considers the use of immunoliposomes as boron carriers nanovehicles to target HER2 overexpressing cells. The essential concerns of the current stage of this proposal are the development of carriers that can improve the efficiency of delivery of boron compounds and the dosimetric assessment of treatment feasibility. For this purpose, an specific pool of clinical cases that can benefit from this application was determined. In this work, we present the proposal and the advances related to the different stages of current research.
authors.affiliation: National Atomic Energy Commission (CNEA), Avenida Del Libertador, 8250 Ciudad de Buenos Aires, Argentina. Electronic address: mgadan@cae.cnea.gov.ar.
authors.forename: M A
authors.initials: MA
authors.lastname: Gadan
authors.affiliation: National Atomic Energy Commission (CNEA), Avenida Del Libertador, 8250 Ciudad de Buenos Aires, Argentina; National Council of Scientific and Technological Research (CONICET), Avenida Rivadavia, 1970 Ciudad de Buenos Aires, Argentina.
authors.forename: S J
authors.initials: SJ
authors.lastname: González
authors.affiliation: National Atomic Energy Commission (CNEA), Avenida Del Libertador, 8250 Ciudad de Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Batalla
authors.affiliation: National Atomic Energy Commission (CNEA), Avenida Del Libertador, 8250 Ciudad de Buenos Aires, Argentina.
authors.forename: M S
authors.initials: MS
authors.lastname: Olivera
authors.affiliation: National Atomic Energy Commission (CNEA), Avenida Del Libertador, 8250 Ciudad de Buenos Aires, Argentina; National Council of Scientific and Technological Research (CONICET), Avenida Rivadavia, 1970 Ciudad de Buenos Aires, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Policastro
authors.affiliation: National Atomic Energy Commission (CNEA), Avenida Del Libertador, 8250 Ciudad de Buenos Aires, Argentina.
authors.forename: M L
authors.initials: ML
authors.lastname: Sztejnberg
mesh_terms: D001118:Argentina; D035843:Biomedical Research / Q000639:trends*; D016754:Boron Neutron Capture Therapy / Q000639:trends*; D001943:Breast Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000517:prevention & control / Q000532:radiotherapy*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human
keywords: HER2-enriched breast cancer; Immunoliposomes; Post treatment recurrences