title: Drug Delivery Innovations for Enhancing the Anticancer Potential of Vitamin E Isoforms and Their Derivatives.
abstract: Vitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E delivery. Furthermore, several drug delivery systems that incorporate Vitamin E isoforms have been synthesized in order to increase the bioavailability of chemotherapeutic agents or to provide a synergistic effect. D-alpha-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) is a synthetic derivative of natural alpha-tocopherol which is gaining increasing interest in the development of drug delivery systems and has also shown promising anticancer effect as a single agent. This review provides a summary of the properties and anticancer effects of the most potent Vitamin E isoforms and an overview of the various formulations developed to improve their efficacy, with an emphasis on the use of TPGS in drug delivery approaches.
authors.affiliation: Department of Biological Sciences, Faculty of Pure and Applied Sciences, University of Cyprus, 1678 Nicosia, Cyprus.
authors.forename: Christiana M
authors.initials: CM
authors.lastname: Neophytou
authors.affiliation: Department of Biological Sciences, Faculty of Pure and Applied Sciences, University of Cyprus, 1678 Nicosia, Cyprus.
authors.forename: Andreas I
authors.initials: AI
authors.lastname: Constantinou
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014810:Vitamin E / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000737:chemistry; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D014810:Vitamin E; D024502:alpha-Tocopherol