title: Evolution of Influenza B Virus in Kuala Lumpur, Malaysia, between 1995 and 2008.
abstract: Influenza B virus causes significant disease but remains understudied in tropical regions. We sequenced 72 influenza B viruses collected in Kuala Lumpur, Malaysia, from 1995 to 2008. The predominant circulating lineage (Victoria or Yamagata) changed every 1 to 3 years, and these shifts were associated with increased incidence of influenza B. We also found poor lineage matches with recommended influenza virus vaccine strains. While most influenza B virus lineages in Malaysia were short-lived, one circulated for 3 to 4 years.
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia jicsam@ummc.edu.my gavin.smith@duke-nus.edu.sg.
authors.forename: I-Ching
authors.initials: IC
authors.lastname: Sam
authors.affiliation: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore.
authors.forename: Yvonne C F
authors.initials: YC
authors.lastname: Su
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Yoke Fun
authors.initials: YF
authors.lastname: Chan
authors.affiliation: Tropical Infectious Diseases Research and Education Centre, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Siti Sarah
authors.initials: SS
authors.lastname: Nor'E
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Ardalinah
authors.initials: A
authors.lastname: Hassan
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Faizatul Lela
authors.initials: FL
authors.lastname: Jafar
authors.affiliation: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore.
authors.forename: Udayan
authors.initials: U
authors.lastname: Joseph
authors.affiliation: J. Craig Venter Institute, Rockville, Maryland, USA.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Halpin
authors.affiliation: Department of Biology, Center for Genomics & Systems Biology, and Global Institute of Public Health, New York University, New York, New York, USA.
authors.forename: Elodie
authors.initials: E
authors.lastname: Ghedin
authors.affiliation: Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: Poh Sim
authors.initials: PS
authors.lastname: Hooi
authors.affiliation: Duke Global Health Institute, Duke University, Durham, North Carolina, USA.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Fourment
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Hamimah
authors.initials: H
authors.lastname: Hassan
authors.affiliation: Tropical Infectious Diseases Research and Education Centre, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Sazaly
authors.initials: S
authors.lastname: AbuBakar
authors.affiliation: J. Craig Venter Institute, Rockville, Maryland, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Wentworth
authors.affiliation: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore Duke Global Health Institute, Duke University, Durham, North Carolina, USA jicsam@ummc.edu.my gavin.smith@duke-nus.edu.sg.
authors.forename: Gavin J D
authors.initials: GJ
authors.lastname: Smith
mesh_terms: D001483:Base Sequence; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D009981:Influenza B virus / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology / Q000235:genetics*; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data