title: Preparation of starch macrocellular foam for increasing the dissolution rate of poorly water-soluble drugs.
abstract: Starch macrocellular foam (SMF), a novel natural bio-matrix material, was prepared by the hard template method in order to improve the dissolution rate and oral bioavailability of poorly water-soluble drugs. Nitrendipine (NDP) was chosen as a model drug and was loaded into SMF by the solvent evaporation method. SMF and the loaded SMF samples (NDP-SMF) were characterized by scanning electron microscopy, differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. In vitro drug release studies showed that SMF significantly increased the dissolution rate of NDP. In vivo studies showed that the NDP-SMF tablets clearly increased the oral bioavailability of NDP in comparison with the reference commercial tablets. All the results obtained demonstrated that SMF was a promising carrier for the oral delivery of poor water-soluble drugs.
authors.affiliation: a Pharmacy School, Liaoning Medical University, Linghe District , Jinzhou , Liaoning Province , P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a Pharmacy School, Liaoning Medical University, Linghe District , Jinzhou , Liaoning Province , P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.affiliation: a Pharmacy School, Liaoning Medical University, Linghe District , Jinzhou , Liaoning Province , P.R. China.
authors.forename: Zongzhe
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: a Pharmacy School, Liaoning Medical University, Linghe District , Jinzhou , Liaoning Province , P.R. China.
authors.forename: Yanna
authors.initials: Y
authors.lastname: Hao
authors.affiliation: a Pharmacy School, Liaoning Medical University, Linghe District , Jinzhou , Liaoning Province , P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: a Pharmacy School, Liaoning Medical University, Linghe District , Jinzhou , Liaoning Province , P.R. China.
authors.forename: Tong
authors.initials: T
authors.lastname: Yu
authors.affiliation: a Pharmacy School, Liaoning Medical University, Linghe District , Jinzhou , Liaoning Province , P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: a Pharmacy School, Liaoning Medical University, Linghe District , Jinzhou , Liaoning Province , P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D065546:Drug Liberation / Q000187:drug effects / Q000502:physiology; D009568:Nitrendipine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits; D011897:Random Allocation; D012995:Solubility; D013213:Starch / Q000737:chemistry / Q000493:pharmacokinetics*; D055682:Viscoelastic Substances / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D014867:Water / Q000737:chemistry / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D000959:Antihypertensive Agents; D055682:Viscoelastic Substances; D014867:Water; D013213:Starch; D009568:Nitrendipine
keywords: Biodegradability; biological safety; nitrendipine; poorly water-soluble drugs; starch macrocellular foam