title: Splenectomy restores tumoricidal activity to promote elimination of intraocular tumors.
abstract: We recently demonstrated that splenectomy restores an interaction between CD8+T cells and macrophages necessary for intraocular tumor elimination. Taking into consideration other studies indicating that intraocular tumor growth does not induce tumor-specific CD8+T-cell tolerance, our data suggest that splenectomy may influence the phenotype of tumor-associated macrophages.
authors.affiliation: Department of Biology; Franciscan University of Steubenville ; Steubenville, OH USA.
authors.forename: Kyle C
authors.initials: KC
authors.lastname: McKenna