title: Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?
abstract: The health-promoting benefits of exercise have been recognized for centuries, yet the molecular and cellular mechanisms for the acute and chronic adaptive response to a variety of physical activities remain incompletely described. This Perspective will take a forward view to highlight emerging questions and frontiers in the ever-changing landscape of exercise biology. The biology of exercise is complex, highly variable, and involves a myriad of adaptive responses in multiple organ systems. Given the multitude of changes that occur in each organ during exercise, future researchers will need to integrate tissue-specific responses with large-scale omics to resolve the integrated biology of exercise. The ultimate goal will be to understand how these system-wide, tissue-specific exercise-induced changes lead to measurable physiological outcomes at the whole-body level to improve health and well-being.
authors.affiliation: Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institute, von Eulers väg 4a, 4 Tr. SE 171 77, Stockholm, Sweden; Department of Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institute, von Eulers väg 4a, 4 Tr. SE 171 77, Stockholm, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK 2200 Copenhagen N, Denmark. Electronic address: juleen.zierath@ki.se.
authors.forename: Juleen R
authors.initials: JR
authors.lastname: Zierath
authors.affiliation: Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institute, von Eulers väg 4a, 4 Tr. SE 171 77, Stockholm, Sweden; Department of Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institute, von Eulers väg 4a, 4 Tr. SE 171 77, Stockholm, Sweden.
authors.forename: Harriet
authors.initials: H
authors.lastname: Wallberg-Henriksson
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D015444:Exercise; D006262:Health; D006801:Humans; D009132:Muscles / Q000502:physiology; D020543:Proteome / Q000378:metabolism
chemical_list: D020543:Proteome