title: A Structured Nursing Intervention to Address Oral Chemotherapy Adherence in Patients With Non-Small Cell Lung Cancer.
abstract: OBJECTIVE
  To evaluate a nurse-led intervention to enhance medication knowledge and adherence using the Multinational Association for Supportive Care in Cancer Oral Agent Teaching Tool (MOATT).
  
  
  METHODS
  Longitudinal, descriptive feasibility study.
  
  
  METHODS
  An ambulatory thoracic oncology disease center located at the Dana-Farber Cancer Institute in Boston, MA.
  
  
  METHODS
  30 adult patients with lung cancer who received the oral agent erlotinib.
  
  
  METHODS
  Structured, nurse-led education sessions using the MOATT were provided, with a 72-hour follow-up telephone contact. Participants completed a Knowledge Rating Scale (KRS) and adapted Morisky Medication Adherence Scale-8 (MMAS-8) at the end of the first cycle of oral chemotherapy.
  
  
  METHODS
  Knowledge and adherence; feasibility.
  
  
  RESULTS
  Twenty-seven participants completed the study outcome measures reporting high knowledge levels and MMAS-8 scores. Structured, nurse-led education and follow-up monitoring sessions ranged from 14-30 minutes. Several participants also initiated contact for assistance with prescription procurement and symptom management. Participants reported a median of two side effects.
  
  
  CONCLUSIONS
  The structured, nurse-led teaching, using the MOATT tool, and follow-up nurse contacts were feasible as integrated into the thoracic oncology setting. Adherence and knowledge outcomes were encouraging. Additional studies should include objective adherence measures and strategies for delivering supportive care to patients at home.
  
  
  CONCLUSIONS
  Structured teaching with patients is important to enhance proper oral anticancer medication knowledge and adherence, including follow-up monitoring of administration and side effects at 72 hours.
authors.affiliation: Phyllis F. Cantor Center at Dana-Farber Cancer Institute in Boston, MA, and the University of Massachusetts Worcester Graduate School of Nursing.
authors.forename: Jean
authors.initials: J
authors.lastname: Boucher
authors.affiliation: Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute.
authors.forename: Joan
authors.initials: J
authors.lastname: Lucca
authors.affiliation: Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute.
authors.forename: Catherine
authors.initials: C
authors.lastname: Hooper
authors.affiliation: Dana-Farber Cancer Institute.
authors.forename: Lillian
authors.initials: L
authors.lastname: Pedulla
authors.affiliation: Phyllis F. Cantor Center at Dana-Farber Cancer Institute.
authors.forename: Donna L
authors.initials: DL
authors.lastname: Berry
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001900:Boston; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000451:nursing*; D000069347:Erlotinib Hydrochloride / Q000008:administration & dosage*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D024802:Nurse's Role; D009723:Nurse-Patient Relations; D009859:Oncology Nursing / Q000379:methods; D010353:Patient Education as Topic / Q000458:organization & administration*; D010865:Pilot Projects; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents; D000069347:Erlotinib Hydrochloride
keywords: adherence; knowledge; lung cancer; oncology nursing; oral chemotherapy