title: Gliomas with intratumoral abscess formation: Description of new cases, review of the literature, and the role of (99m)TC-Leukoscan.
abstract: Abscess formation within a brain tumor is uncommon. Intrasellar or parasellar tumors are the most common neoplasms that develop such complications. Cerebral gliomas with abscesses are extremely rare. In this paper three rare cases of glioma associated with abscess formation are described. The diagnosis of brain tumor associated with abscess is particularly difficult by conventional neuroradiological studies. (99m)Tc-labeled sulesomab can be useful in the diagnosis of brain tumors with intratumoral abscesses. There are no precise guidelines for the diagnosis and treatment of cerebral gliomas associated with abscesses formation for the low number of cases reported to date. Appropriate treatment, aimed at radical surgery, and a suitable antibiotic-protocol, deferring adjuvant postoperative therapy, is associated with a more favorable outcome. A review of the pertinent literature is also performed.
authors.affiliation: Nuclear Medicine Unit, Department of Biomedical Sciences, Morphological and Functional Images, University of Messina School of Medicine, Messina, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Campennì
authors.affiliation: Neurosurgical Clinic, Department of Neuroscience, University of Messina School of Medicine, Messina, Italy. Electronic address: gcaruso@unime.it.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Caruso
authors.affiliation: Department of Human Pathology, University of Messina School of Medicine, Messina, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Barresi
authors.affiliation: Neurosurgical Clinic, Department of Neuroscience, University of Messina School of Medicine, Messina, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Pino
authors.affiliation: Nuclear Medicine Unit, Department of Biomedical Sciences, Morphological and Functional Images, University of Messina School of Medicine, Messina, Italy.
authors.forename: Mariapaola
authors.initials: M
authors.lastname: Cucinotta
authors.affiliation: Nuclear Medicine Unit, Department of Biomedical Sciences, Morphological and Functional Images, University of Messina School of Medicine, Messina, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Baldari
authors.affiliation: Neurosurgical Clinic, Department of Neuroscience, University of Messina School of Medicine, Messina, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Caffo
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D001922:Brain Abscess / Q000188:drug therapy* / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014054:Tomography
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; C101172:Sulesomab
keywords: Brain abscess; Cerebral gliomas; Intratumoral abscess; Leukoscan; Sulesomab