title: HEREDITARY ANGIOEDEMA: A Literature Review and National Management Guidelines.
abstract: BACKGROUND
  Hereditary angioedema, a rare and potentially life-threatening condition, is the result of a defect in the C1 esterase inhibitor. Primary care physicians should be familiar with this condition to avoid complications and improve quality of care.
  
  
  METHODS
  We present two cases of hereditary angioedema followed by a discussion based on a literature review of the recent guidelines and advances in this condition.
  
  
  OBJECTIVE
  To highlight the clinical aspects, diagnosis and treatment of this condition and propose a practical local management based on the available medication.
  
  
  CONCLUSIONS
  Hereditary angioedema management is still evolving. More efforts should be made concerning the drug therapy which is very costly and not available worldwide.
authors.forename: Ramez
authors.initials: R
authors.lastname: Azzam
authors.forename: Jacques
authors.initials: J
authors.lastname: Boutros
authors.forename: Carla
authors.initials: C
authors.lastname: Irani
mesh_terms: D000328:Adult; D054179:Angioedemas, Hereditary / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010949:Plasma; D017410:Practice Guidelines as Topic; D014081:Tooth Extraction
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone