title: Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson's disease.
abstract: Cerebello-thalamo-cortical circuit has been indicated important for tremor in Parkinson's disease (PD), but the role of dentate nucleus (DN) in parkinsonian tremor remains unclear. To investigate whether DN plays a role in PD tremor, we recruited 50 PD and 29 age-matched health controls (HC). The patients were divided into tremor-dominant (TD) and non-tremor-dominant (NTD) groups. We collected resting-state fMRIs data for each subject. The bilateral DN was then chosen as the region of interest to examine PD tremor-related network changes, as well as its correlation with tremor severity. Voxel-wise functional connectivity analysis revealed that the bilateral DN had higher connectivity with the bilateral cerebellar anterior lobe, and had lower connectivity with the bilateral prefrontal cortex in TD compared to the HC and NTD groups. Functional connectivity of the bilateral DN with the bilateral cerebellar posterior lobe was also higher in TD than NTD group. Functional connectivity between the bilateral DN and the bilateral cerebellar posterior lobe showed positive correlation with tremor severity, while that between the bilateral DN and the bilateral prefrontal cortex displayed negative correlation. Our study demonstrates higher dentato-cerebellar connectivity and lower dentato-prefrontal connectivity in TD patients, which might be involved in the pathogenesis of PD tremor. And we conclude that DN might be associated with the pathogenesis of PD tremor.
authors.affiliation: Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors.forename: Huizi
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Ma
authors.affiliation: Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.|Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.|Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.|Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
authors.forename: Jiarong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing, 100050, China. bxbkyjs@sina.com.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China. bxbkyjs@sina.com.|Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. bxbkyjs@sina.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
mesh_terms: D000368:Aged; D002529:Cerebellar Nuclei / Q000503:physiopathology*; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D014202:Tremor / Q000209:etiology / Q000503:physiopathology*
keywords: Dentate nucleus; Functional connectivity; Parkinson’s disease; Tremor; fMRI