title: Evaluation of substituted methyl cyclohexanone hybrids for anti-tubercular, anti-bacterial and anti-fungal activity: Facile syntheses under catalysis by ionic liquids.
abstract: An library of unresolved racemic Mannich bases incorporating two stereogenic carbon centers was evaluated for antibacterial activity against clinically isolated Gram-positive bacteria i.e. Staphylococcus aureus, Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa and for antifungal activity against Candida albicans strains. Additionally, the susceptibility of microorganisms to Mannich bases prompted us to evaluate the potential for anti-tubercular activity against clinically isolated Mycobacterium tuberculosis and virulent H37Rv strains. All compounds showed potent activity against M. tuberculosis strains at MIC ranging from 50 μg/mL to 6.25 μg/mL of concentration. Facile one pot Mannich type syntheses of rac-(2S)-2-[(R)-[(4-substituted phenyl){[4-(4-substituted phenyl)-1,3-thiazol-2-yl]amino}methyl]cyclohexanone derivatives were achieved by reactions of various 2-amino-4-aryl-thiazoles, appropriately substituted aromatic aldehydes and cyclohexanone in Bronsted acidic quaternary ammonium sulfated ionic liquids serving as dual solvents and catalysts.
authors.affiliation: Department of Chemistry, Dhote Bandhu Science College, Gondia 441614, India. Electronic address: ajay.ghatole5@gmail.com.
authors.forename: Ajay M
authors.initials: AM
authors.lastname: Ghatole
authors.affiliation: Department of Chemistry, Mohsinbhai Zawer College, Wadsa, Desaigang, India.
authors.forename: Kushal R
authors.initials: KR
authors.lastname: Lanjewar
authors.affiliation: Department of Chemistry, Shri Lemdeo Patil Mahavidyalaya, Mandhal, Kuhi, India.
authors.forename: Mahesh K
authors.initials: MK
authors.lastname: Gaidhane
authors.affiliation: Department of Chemistry, Dhote Bandhu Science College, Gondia 441614, India.
authors.forename: Kishor M
authors.initials: KM
authors.lastname: Hatzade
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects*; D003512:Cyclohexanones / Q000737:chemistry* / Q000494:pharmacology*; D052578:Ionic Liquids / Q000737:chemistry*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000995:Antitubercular Agents; D003512:Cyclohexanones; D052578:Ionic Liquids; C036468:cyclohexanone
keywords: Anti-microbial activities; Anti-tubercular; Bronsted acidic quaternary ammonium ionic liquids; Mannich bases; rac-(2S)-2-[(R)-[(4-substituted phenyl){[4-(4-substituted phenyl)-1,3-thiazol-2-yl]amino}methyl]cyclohexanones