title: The Role of the XPF Gene Polymorphism (Xrcc4) Ser835ser in the Risk of Malignant Transformation of Cells in the Colorectal Cancer.
abstract: Participation of DNA repair systems in the pathogenesis of cancer has been a suspected phenomenon for a long time. Decreased efficiency in DNA repair translates to their ability to fix and consequently leads to mutations and the process of carcinogenesis. Linking individual polymorphisms of DNA repair systems with an increased risk of colorectal cancer will allow the classification of patients to high-risk groups and their placement under preventive program. The aim of the study was to determine the effect of XPF gene polymorphism Ser835Ser on increasing the risk of colorectal cancer in the Polish population.
  
  
  METHODS
  as the material blood collected from 146 patients diagnosed with colon cancer was used. The control group consisted of 149 healthy subjects. Genotyping was performed by Taq- Man method.
  
  
  RESULTS
  The results indicate that genotype TCC/TCT is associated with an decreased risk of colorectal cancer (OR 0.574; CI 95% 0.335-0.984; p=0.043).
  
  
  CONCLUSIONS
  Based on these results, we conclude that the XPF gene polymorphism Ser835Ser may be associated with a decreased risk of colorectal cancer.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kabziński
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Majsterek
authors.forename: Adam
authors.initials: A
authors.lastname: Dziki
authors.forename: Michał
authors.initials: M
authors.lastname: Mik
mesh_terms: D000483:Alleles; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011044:Poland / Q000453:epidemiology; D044465:White People / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C095888:xeroderma pigmentosum group F protein