title: Excitation-resolved cone-beam x-ray luminescence tomography.
abstract: Cone-beam x-ray luminescence computed tomography (CB-XLCT), as an emerging imaging technique, plays an important role in in vivo small animal imaging studies. However, CB-XLCT suffers from low-spatial resolution due to the ill-posed nature of reconstruction. We improve the imaging performance of CB-XLCT by using a multiband excitation-resolved imaging scheme combined with principal component analysis. To evaluate the performance of the proposed method, the physical phantom experiment is performed with a custom-made XLCT/XCT imaging system. The experimental results validate the feasibility of the method, where two adjacent nanophosphors (with an edge-to-edge distance of 2.4 mm) can be located.
authors.affiliation: Shanghai University, School of Communication and Information Engineering, Shanghai 200444, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Fourth Military Medical University, Department of Biomedical Engineering, Xi'an 710032, China.
authors.forename: Qimei
authors.initials: Q
authors.lastname: Liao
authors.affiliation: Dalian University of Technology, Department of Biomedical Engineering, Dalian 116024, China.
authors.forename: Hongkai
authors.initials: H
authors.lastname: Wang
authors.affiliation: Shanghai University, School of Communication and Information Engineering, Shanghai 200444, China.
authors.forename: Zhuangzhi
authors.initials: Z
authors.lastname: Yan
mesh_terms: D054893:Cone-Beam Computed Tomography / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D049329:Nanostructures; D019047:Phantoms, Imaging; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*