title: Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells.
abstract: Biodegradable bridged silsesquioxane (BS) nanomaterials for two-photon-excited (TPE) imaging and therapy of breast cancer cells were described. A versatile synthesis was developed to design monodisperse tetra-alkoxysilylated diamino-diphenylbutadiene or Zn-porphyrin-based nanospheres of 30 to 50 nm.
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM cc 1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France. durand@um2.fr.
authors.forename: Jonas G
authors.initials: JG
authors.lastname: Croissant
authors.forename: Chiara
authors.initials: C
authors.lastname: Mauriello-Jimenez
authors.forename: Marie
authors.initials: M
authors.lastname: Maynadier
authors.forename: Xavier
authors.initials: X
authors.lastname: Cattoën
authors.forename: Michel
authors.initials: M
authors.lastname: Wong Chi Man
authors.forename: Laurence
authors.initials: L
authors.lastname: Raehm
authors.forename: Olivier
authors.initials: O
authors.lastname: Mongin
authors.forename: Mireille
authors.initials: M
authors.lastname: Blanchard-Desce
authors.forename: Marcel
authors.initials: M
authors.lastname: Garcia
authors.forename: Magali
authors.initials: M
authors.lastname: Gary-Bobo
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Durand
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004220:Disulfides / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D061986:MCF-7 Cells; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use*; D010316:Particle Size; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D004220:Disulfides; D017646:Organosilicon Compounds; D017319:Photosensitizing Agents