title: [The brain-gut axis: insights from the obese pig model].
abstract: The pig, which shares several similarities with humans, is increasingly used for biomedical research, particularly in nutrition and neurosciences. Recent studies in minipigs have shown that a deleterious nutritional environment (e.g. a high-fat and high-sugar diet) induces obesity which, as in humans, is associated with increased adiposity, insulin resistance, modified eating behaviour, and altered gastric function and intestinal sensitivity. These changes are accompanied by differences in the activation matrices and metabolic activity of several brain areas. Using this animal model, we have revisited the concept of dual hedonic and homeostatic control of food intake. We have thus developed a minimally invasive and potentially reversible surgical approach to the control of food intake, as an alternative to bariatric surgery, based on chronic vagal stimulation at the abdominal level.
authors.affiliation: Unité Alimentation & Adaptations Digestives, Nerveuses et Comportementales, INRA, Domaine de la Prise - 35590 Saint-Gilles, France. charles-henri.malbert@rennes.inra.fr
authors.forename: Charles-Henri
authors.initials: CH
authors.lastname: Malbert
mesh_terms: D050154:Adiposity / Q000502:physiology; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004040:Dietary Carbohydrates / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy; D002149:Energy Intake; D005247:Feeding Behavior / Q000502:physiology; D015390:Gastric Bypass; D013271:Gastric Dilatation / Q000503:physiopathology; D041981:Gastrointestinal Tract / Q000294:innervation / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000209:etiology / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D044343:Overnutrition / Q000503:physiopathology / Q000662:veterinary; D011964:Receptors, Gastrointestinal Hormone / Q000235:genetics / Q000502:physiology; D012528:Satiety Response / Q000502:physiology; D013552:Swine; D013553:Swine Diseases / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D013556:Swine, Miniature / Q000235:genetics / Q000502:physiology*; D014161:Transduction, Genetic; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D011964:Receptors, Gastrointestinal Hormone; C041086:gastric inhibitory polypeptide receptor