title: Eicosanoid storm in infection and inflammation.
abstract: Controlled immune responses to infection and injury involve complex molecular signalling networks with coordinated and often opposing actions. Eicosanoids and related bioactive lipid mediators derived from polyunsaturated fatty acids constitute a major bioactive lipid network that is among the most complex and challenging pathways to map in a physiological context. Eicosanoid signalling, similar to cytokine signalling and inflammasome formation, has primarily been viewed as a pro-inflammatory component of the innate immune response; however, recent advances in lipidomics have helped to elucidate unique eicosanoids and related docosanoids with anti-inflammatory and pro-resolution functions. This has advanced our overall understanding of the inflammatory response and its therapeutic implications. The induction of a pro-inflammatory and anti-inflammatory eicosanoid storm through the activation of inflammatory receptors by infectious agents is reviewed here.
authors.affiliation: Department of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Dennis
authors.affiliation: Department of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Norris
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D015777:Eicosanoids / Q000096:biosynthesis / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000473:pathology; D018836:Inflammation Mediators / Q000276:immunology* / Q000378:metabolism; D050356:Lipid Metabolism / Q000276:immunology*; D010740:Phospholipases / Q000235:genetics / Q000276:immunology; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D015777:Eicosanoids; D018836:Inflammation Mediators; D003577:Cytochrome P-450 Enzyme System; D011451:Prostaglandin-Endoperoxide Synthases; D010740:Phospholipases