title: Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation.
abstract: BACKGROUND
  Previous studies proposed that both inflammation, oxidative stress, and impaired endothelial dysfunction have a significant role in occurrence of slow coronary flow (SCF). monocyte-to-high density lipoprotein cholesterol ratio (MHR) is a recently emerged indicator of inflammation and oxidative stress, which have been studied only in patients with chronic kidney disease.
  
  
  OBJECTIVE
  We aimed to assess the relationship between MHR and SCF.
  
  
  METHODS
  Patients who had angiographically normal coronary arteries were enrolled in this retrospective study (n = 253 as SCF group and n = 176 as control group). Patients who had corrected thrombolysis in myocardial infarction frame counts (cTFCs) above the normal cutoffs were defined as with SCF.
  
  
  RESULTS
  The MHR and high-sensitivity C-reactive protein (hsCRP) were significantly higher in the SCF group. In correlation analysis, MHR has a significantly positive correlation with cTFC and serum hsCRP levels (P < .001). In multivariate logistic regression analysis, MHR was found as independently associated with the presence of SCF (odds ratio: 1.24, P < .001).
  
  
  CONCLUSIONS
  Higher MHR which indicates an enhanced inflammation and oxidative stress was significantly and independently associated with the presence of SCF. Besides, MHR was positively correlated with serum hsCRP level as a conventional marker for systemic inflammation.
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey dru_canpolat@yahoo.com.
authors.forename: Ugur
authors.initials: U
authors.lastname: Canpolat
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Elif Hande
authors.initials: EH
authors.lastname: Çetin
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Cetin
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Mehmet Kadri
authors.initials: MK
authors.lastname: Akboga
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Yayla
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Turak
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydogdu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology*; D054318:No-Reflow Phenomenon / Q000097:blood; D018384:Oxidative Stress; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL
keywords: coronary slow flow; high-density lipoprotein cholesterol; inflammation; monocyte count