title: Parenchymal texture analysis in digital mammography: robust texture feature identification and equivalence across devices.
abstract: An analytical framework is presented for evaluating the equivalence of parenchymal texture features across different full-field digital mammography (FFDM) systems using a physical breast phantom. Phantom images (FOR PROCESSING) are acquired from three FFDM systems using their automated exposure control setting. A panel of texture features, including gray-level histogram, co-occurrence, run length, and structural descriptors, are extracted. To identify features that are robust across imaging systems, a series of equivalence tests are performed on the feature distributions, in which the extent of their intersystem variation is compared to their intrasystem variation via the Hodges-Lehmann test statistic. Overall, histogram and structural features tend to be most robust across all systems, and certain features, such as edge enhancement, tend to be more robust to intergenerational differences between detectors of a single vendor than to intervendor differences. Texture features extracted from larger regions of interest (i.e., [Formula: see text]) and with a larger offset length (i.e., [Formula: see text]), when applicable, also appear to be more robust across imaging systems. This framework and observations from our experiments may benefit applications utilizing mammographic texture analysis on images acquired in multivendor settings, such as in multicenter studies of computer-aided detection and breast cancer risk assessment.
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Brad M
authors.initials: BM
authors.lastname: Keller
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Andrew
authors.initials: A
authors.lastname: Oustimov
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Biostatistics and Epidemiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Chen
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Acciavatti
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Yuanjie
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Shonket
authors.initials: S
authors.lastname: Ray
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: James C
authors.initials: JC
authors.lastname: Gee
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Andrew D A
authors.initials: AD
authors.lastname: Maidment
authors.affiliation: University of Pennsylvania , Perelman School of Medicine, Department of Radiology, 3600 Market Street, Suite 360, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Despina
authors.initials: D
authors.lastname: Kontos
keywords: digital mammography; parenchymal pattern; robust texture features