title: High Definition Colonoscopy Combined with i-SCAN Imaging Technology Is Superior in the Detection of Adenomas and Advanced Lesions Compared to High Definition Colonoscopy Alone.
abstract: Background. Improved detection of adenomatous polyps using i-SCAN has mixed results in small studies. Utility of i-SCAN as a primary surveillance modality for colorectal cancer screening during colonoscopy is uncertain. Aim. Comparing high definition white light endoscopy (HDWLE) to i-SCAN in their ability to detect adenomas during colonoscopy. Methods. Prospective cohort study of 1936 average risk patients who had a screening colonoscopy at an ambulatory procedure center. Patients underwent colonoscopy with high definition white light endoscopy withdrawal versus i-SCAN withdrawal during endoscopic screening exam. Primary outcome measurement was adenoma detection rate for i-SCAN versus high definition white light endoscopy. Secondary measurements included polyp size, pathology, and morphology. Results. 1007 patients underwent colonoscopy with i-SCAN and 929 with HDWLE. 618 adenomas were detected in the i-SCAN group compared to 402 in the HDWLE group (p < 0.01). More advanced adenomas (≥10 mm) were found by i-SCAN, 79 versus 47 (p = 0.021) and based upon histology alone 37 versus 18 (p = 0.028). Conclusions. i-SCAN detected significantly more adenomas and advanced adenomas compared to high definition white light endoscopy.
authors.affiliation: Department of Medicine, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA ; Division of Gastroenterology and Hepatology, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Erik A
authors.initials: EA
authors.lastname: Bowman
authors.affiliation: Department of Medicine, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA ; Division of Gastroenterology and Hepatology, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Pfau
authors.affiliation: Department of Medicine, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Arnab
authors.initials: A
authors.lastname: Mitra
authors.affiliation: Department of Medicine, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA ; Division of Gastroenterology and Hepatology, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Reichelderfer
authors.affiliation: Department of Medicine, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA ; Division of Gastroenterology and Hepatology, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Deepak V
authors.initials: DV
authors.lastname: Gopal
authors.affiliation: Department of Medicine, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA ; Division of Gastroenterology and Hepatology, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Hall
authors.affiliation: Department of Medicine, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA ; Division of Gastroenterology and Hepatology, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Benson