title: Murine and human mast cell progenitors.
abstract: The development of mature mast cells (MCs) from hematopoietic progenitor cells as well as the identification and characterization of committed progenitor cells are a current focus of mast cell research. Most published reports in this area are on the origin and differentiation of MCs in mice. Evidence for the human system, i.e. derived from primary human MCs, is widely lacking. Based on the published data, MCs develop either from a committed progenitor or from a common basophil/mast cell precursor. This review summarizes the current knowledge on MC development and MC differentiation.
authors.affiliation: Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Schmetzer
authors.affiliation: Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Patricia
authors.initials: P
authors.lastname: Valentin
authors.affiliation: Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Martin K
authors.initials: MK
authors.lastname: Church
authors.affiliation: Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Maurer
authors.affiliation: Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: frank.siebenhaar@charite.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Siebenhaar
mesh_terms: D000818:Animals; D006801:Humans; D008407:Mast Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D013234:Stem Cells / Q000166:cytology*
keywords: Development; Differentiation; HSC; Mast cell; Progenitor