title: SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(SUBSTITUTED PHENYL)-2-(5H-[1,2,4]TRIAZINO[5,6-b]INDOL-3-YLSULFANYL)ACETAMIDES AS ANTIMICROBIAL, ANTIDEPRESSANT AND ANTICONVULSANT AGENTS.
abstract: A new series of N-Aryl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides were synthesized by condensation of tricyclic compound 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione with chloro N-phenylacetamides. The tricyclic compound was obtained by condensation of Isatin with thiosemicarbazide. Chloro N-phenylacetamides were obtained from different substituted anilines. Their structures were characterized by IR, 1H NMR, LC-MS and elemental analyses. Newly synthesized compounds were screened for antimicrobial, antidepressant and anticonvulsant activities. Preliminary results indicated that most of the compounds showed lesser MIC value than the standard drug used when tested for antimicrobial activity. Some of the compounds were endowed with very good antidepressant and anticonvulsant activity.
authors.forename: N
authors.initials: N
authors.lastname: Shruthi
authors.forename: Boja
authors.initials: B
authors.lastname: Poojary
authors.forename: Vasantha
authors.initials: V
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Prathibha
authors.forename: Mumtaz Mohammed
authors.initials: MM
authors.lastname: Hussain
authors.forename: B C
authors.initials: BC
authors.lastname: Revanasiddappa
authors.forename: Himanshu
authors.initials: H
authors.lastname: Joshi
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice
chemical_list: D000890:Anti-Infective Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents