title: Increased prevalence of comorbid conditions in women with uterine cancer.
abstract: OBJECTIVE
  To compare comorbidities of women with uterine cancer (UC) to controls so as to aid in development of survivorship care plans and programs.
  
  
  METHODS
  Retrospective cohort study using the University HealthSystem Consortium (UHC) database that compared women who had a hysterectomy for UC to women without UC undergoing hysterectomy. Frequencies and odds ratios (ORs) of 26 comorbidities were calculated. Mantel-Haenszel stratified ORs were determined to correct for different age distributions between the UC and control groups using UHC predetermined age groups.
  
  
  RESULTS
  23,227 patients in the dataset were included in the UC cohort, and 142,601 patients served as controls. Uncorrected ORs≥2 were found for hypertension, diabetes, obesity, congestive heart failure, pulmonary circulatory diseases, peripheral vascular disease, and renal failure. Higher ORs for UC remained significant after stratification by age for hypertension (OR=1.7), diabetes (OR=2.1), obesity (OR=3.3), congestive heart failure (OR=1.5), pulmonary circulatory disorders (OR=1.7), and renal failure (OR=1.2).
  
  
  CONCLUSIONS
  Multiple comorbid conditions, specifically those related to the metabolic syndrome, were more prevalent in UC survivors than in the general population, and this difference persisted after adjustment for age. UC survivorship programs should plan to allocate resources to account for these differences in healthcare needs.
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, Rebecca and John Moores Cancer Center, San Diego, CA, USA. Electronic address: kckurnit@gmail.com.
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Kurnit
authors.affiliation: University of Florida College of Medicine- Jacksonville, Jacksonville, FL, USA.
authors.forename: Kristy K
authors.initials: KK
authors.lastname: Ward
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, Rebecca and John Moores Cancer Center, San Diego, CA, USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: McHale
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, Rebecca and John Moores Cancer Center, San Diego, CA, USA.
authors.forename: Cheryl C
authors.initials: CC
authors.lastname: Saenz
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, Rebecca and John Moores Cancer Center, San Diego, CA, USA.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Plaxe
mesh_terms: D000367:Age Factors; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology*
keywords: Comorbid conditions; Survivorship programs; Uterine cancer