title: Prevalence of Kaposi's sarcoma associated herpesvirus among men attending sexually transmitted infections clinics in Anhui, China.
abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) may be transmitted via sexual contacts, but limited information is available on KSHV infection status among sexually transmitted infection (STI) patients in China. The main objective of the present study was to determine the KSHV seroprevalence and its risk factors among male STI patients. A cross-sectional survey was conducted in three prefectures of Anhui province, China, between June and September 2013. A total of 1,600 male patients who visited an STI clinic were invited, and 1,372 participated in the study. Data were abstracted from the medical records for all the patients. Blood samples were collected and tested for antibodies to KSHV, HIV, HCV, and syphilis. Factors associated with KSHV seropositivity were examined using multivariable logistic regression analysis. The overall prevalence of KSHV, HIV, HCV, and syphilis was 13.3%, 0.7%, 0.6%, and 12.5%, respectively. After adjusting for potential confounders, KSHV infection was significantly associated with ever having anal sex with men (19 out of 30 males, OR: 8.64, 95%CI: 1.92-38.79) and HIV infection (six out of nine HIV-positive individuals, OR: 8.39, 95%CI: 1.80-39.04). There were no significant associations of KSHV infection with drug use, heterosexual sex behaviors, syphilis, and HCV. Our finding has shown that a relatively moderate prevalence of KSHV was found among male STI patients. While an increased risk for KSHV infection was observed among participants with homosexual contacts. Routine KSHV testing is recommended for male individuals attending STI clinics.
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Anhui Provincial Institute of Dermatology and Venereology, Hefei, Anhui, China.
authors.forename: Shuying
authors.initials: S
authors.lastname: Liu
authors.affiliation: School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Cao
authors.affiliation: School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ontario, Canada.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Nebraska Center of Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska.
authors.forename: Veenu
authors.initials: V
authors.lastname: Minhas
authors.affiliation: Nebraska Center of Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska.
authors.forename: Charles
authors.initials: C
authors.lastname: Wood
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000554:Ambulatory Care Facilities; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D016174:Hepacivirus; D006564:Herpesviridae; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000453:epidemiology* / Q000821:virology; D016036:Seroepidemiologic Studies; D012749:Sexually Transmitted Diseases / Q000453:epidemiology* / Q000821:virology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: China; Kaposi's sarcoma-associated herpesvirus; prevalence