title: Intrahippocampal injection of TsTX-I increases the levels of INF-γ in the cerebral tissue but not the levels of glutamate.
abstract: TsTX-I, isolated from Tityus serrulatus scorpion venom, causes epileptic-like discharges when injected into the central nervous system. The involvement of excitatory amino acids and cytokines in this activity was investigated. Our results have demonstrated that TsTX-I increases the release of IFN-γ but does not alter the intracerebral concentration of the excitatory amino acids in rats. Thus, this cytokine seems to be more important in the convulsive process than glutamate.
authors.affiliation: Laboratory of Pharmacology, Butantan Institute, São Paulo, Brazil; Post-Graduation Program in Toxinology of Butantan Institute, São Paulo, Brazil.
authors.forename: Renan Volner
authors.initials: RV
authors.lastname: Rodriguez
authors.affiliation: Laboratory of Pharmacology, Butantan Institute, São Paulo, Brazil.
authors.forename: Valquiria Abrão Coronado
authors.initials: VA
authors.lastname: Dorce
authors.affiliation: Laboratory of Pharmacology, Butantan Institute, São Paulo, Brazil.
authors.forename: Lucas Alves
authors.initials: LA
authors.lastname: de Freitas
authors.affiliation: Laboratory of Pharmacology, Butantan Institute, São Paulo, Brazil.
authors.forename: Ana Leticia Coronado
authors.initials: AL
authors.lastname: Dorce
authors.affiliation: Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, Brazil.
authors.forename: Ivo
authors.initials: I
authors.lastname: Lebrun
authors.affiliation: Laboratory of Pharmacology, Butantan Institute, São Paulo, Brazil.
authors.forename: Ana Claudia Martins
authors.initials: AC
authors.lastname: Sobral
authors.affiliation: Laboratory of Immunochemistry, Butantan Institute, São Paulo, Brazil.
authors.forename: Fernanda Calheta Vieira
authors.initials: FC
authors.lastname: Portaro
authors.affiliation: Laboratory of Immunochemistry, Butantan Institute, São Paulo, Brazil.
authors.forename: Alexandre Kazuo
authors.initials: AK
authors.lastname: Kuniyoshi
authors.affiliation: Laboratory of Immunochemistry, Butantan Institute, São Paulo, Brazil.
authors.forename: Daniela Cajado
authors.initials: DC
authors.lastname: Carvalho
authors.affiliation: Laboratory of Pharmacology, Butantan Institute, São Paulo, Brazil. Electronic address: analeonor@butantan.gov.br.
authors.forename: Ana Leonor Abrahão
authors.initials: AL
authors.lastname: Nencioni
mesh_terms: D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007371:Interferon-gamma / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism; D053582:Interleukin-1alpha / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D051381:Rats; D012604:Scorpion Venoms / Q000008:administration & dosage* / Q000633:toxicity*; D012605:Scorpions / Q000378:metabolism
chemical_list: D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D012604:Scorpion Venoms; D016753:Interleukin-10; D018698:Glutamic Acid; D007371:Interferon-gamma
keywords: Convulsion; Cytokines; Glutamate; Hippocampus; Tityus serrulatus scorpion; TsTX-I