title: Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study.
abstract: OBJECTIVE
  To evaluate the prognostic effects of neoadjuvant chemotherapy (NAC) in patients with local advanced gastric cancer.
  
  
  METHODS
  We retrospectively analyzed prognosis in 191 patients with advanced gastric cancer, of whom 71 were treated with NAC and 120 received surgery only between February 2007 and July 2013. Postoperative complication rate was recorded. Survival by clinicopathological features, pathological T and N stages, and histopathological tumor regression was retrospectively compared between the two groups.
  
  
  RESULTS
  According to Response Evaluation Criteria in Solid Tumors, none of the 71 patients in the NAC followed by surgery group showed complete response, 36 showed partial response, 25 had stable disease, and 10 had progressive disease. The chemotherapy response rate was 50.7%; the disease control rate was 85.9%. Grade 3/4 adverse events were seen in less than 20% patients, with acceptable toxicities. No difference was found in the overall postoperative complication rates between the two groups (7 versus 22 cases, P=0.18). Median survival time was significantly different, at 54 months in the NAC combined with surgery group and 25 months in the surgery-only group (P=0.025).
  
  
  CONCLUSIONS
  In patients with operable gastric adenocarcinomas, NAC can significantly improve overall survival without increasing surgical complications.
authors.forename: Shu-bo
authors.initials: SB
authors.lastname: Tian
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Yu
authors.forename: Wei-ming
authors.initials: WM
authors.lastname: Kang
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Ma
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
authors.forename: Chao
authors.initials: C
authors.lastname: Yan
authors.forename: Ya-kai
authors.initials: YK
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology