title: Comparing effects of low and high-flow anesthesia on hemorheology and coagulation factors.
abstract: OBJECTIVE
  In the current study, we compared the effects of low- and high-flow anesthesia techniques on hemorheology and coagulation parameters in patients who received sevofluran.
  
  
  METHODS
  Forty patients classified as Risk Group I-II according to American Society of Anesthesiologists' (ASA) guidelines who were scheduled to undergo general anesthesia were randomly assigned to one of two groups. Low-flow anesthesia was administered to the first group, and high-flow anesthesia was used in the second group. Blood samples were obtained in the preoperative and peroperative periods (at 60 and 120 min) for determination of blood and plasma viscosity, plasma oncotic pressure, international normalized ratio (INR), phorotrombin time (PT), activated partial phorotrombin time (aPTT) and fibrinogen. Blood was also drawn for analysis of factor VIII (FVIII) activity, which was measured in the preoperative period and at postoperative six hour.
  
  
  RESULTS
  The peroperative plasma viscosity was significantly low in Group 1 relative to Group 2. aPTT was significantly elevated at 60 minutes in Group 1 relative to Group 2, but the increase at 120 minutes was not significant.
  
  
  CONCLUSIONS
  The effects of low-flow anesthesia on hemorheology were greater than those of high-flow anesthesia.
authors.affiliation: Orhan Binici, MD. Anesthesiology and Reanimation, Erzincan State Hospital, Erzincan, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Binici
authors.affiliation: Ismail Kati, MD. Yuzuncuyil University Medical Faculty, Anesthesiology and Reanimation, Van, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Kati
authors.affiliation: Ugur Goktas, MD. Yuzuncuyil University Medical Faculty, Anesthesiology and Reanimation, Van, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Goktas
authors.affiliation: Lokman Soyaral, MD. Yuzuncuyil University Medical Faculty, Anesthesiology and Reanimation, Van, Turkey.
authors.forename: Lokman
authors.initials: L
authors.lastname: Soyaral
authors.affiliation: Osman Cagatay Aytekin, MD. Yuzuncuyil University Medical Faculty, Anesthesiology and Reanimation, Van, Turkey.
authors.forename: Osman Cagatay
authors.initials: OC
authors.lastname: Aytekin
keywords: Cogulation; Hemorheology; Low flow anesthesia