title: Hereditary diffuse gastric cancer--An overview.
abstract: The incidence of gastric cancer varies by up to ten fold throughout the world, and the geographic distribution of hereditary cases is not well explored. Familial clustering is seen in 10% of cases, and approximately 3% of all gastric cancers develop due to hereditary diffuse gastric cancer (HDGC). In this review, the characteristics of HDGC are presented according to molecular particularities, geographic distribution, and other parameters. Based on our experience and the data from the literature, we discuss the possibility of applying a mutation signature (spectrum) study and adductomic approaches to a comparative carcinogenesis of HDGC. We also provide a comprehensive, up-to-date review of genetic counseling and criteria for screening and surveillance of eligible families.
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Romania. Electronic address: simonagurzu@yahoo.com.
authors.forename: Simona
authors.initials: S
authors.lastname: Gurzu
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Romania.
authors.forename: Ioan
authors.initials: I
authors.lastname: Jung
authors.affiliation: Department of Pathology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
authors.forename: Janina
authors.initials: J
authors.lastname: Orlowska
authors.affiliation: Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sugimura
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Romania; Department of Oncology, University of Medicine and Pharmacy of Tirgu-Mures, Romania.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Kadar
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Romania.
authors.forename: Sabin
authors.initials: S
authors.lastname: Turdean
authors.affiliation: Department of Surgery, University of Medicine and Pharmacy of Tirgu-Mures, Romania.
authors.forename: Tivadar
authors.initials: T
authors.lastname: Bara
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D004252:DNA Mutational Analysis; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D040941:Heredity; D006801:Humans; D015994:Incidence; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor
keywords: Adductomics; Ethnic difference; Geographic distribution; Hereditary gastric cancer