title: Net gain analysis, an addition to responder analysis--The case of antipsychotic treatment of acute mania.
abstract: Net Gain Analysis (NGA) is proposed as an alternative to Responders Analysis (RA) as a more comprehensive method to tap clinical relevance of the effect of treatment. NGA is the group difference in responders minus the group difference in deteriorators; while RA is the group difference in responders. We examined the performance of these two methods in a dataset consisting of individual patient data from 10 randomized controlled trials (N = 2666) of five different antipsychotics in patients with acute mania by comparing the rank ordering of the five compounds according to both systems (NGA and RA). The rank order did not differ between the 2 systems but the inferiority of one compound was revealed more evidently by the NGA in comparison to the RA.
authors.affiliation: Dept. of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Medicines Evaluation Board, Utrecht, The Netherlands. Electronic address: c.c.welten@amc.uva.nl.
authors.forename: C C M
authors.initials: CC
authors.lastname: Welten
authors.affiliation: Dept. of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: M W J
authors.initials: MW
authors.lastname: Koeter
authors.affiliation: Medicines Evaluation Board, Utrecht, The Netherlands.
authors.forename: T D
authors.initials: TD
authors.lastname: Wohlfarth
authors.affiliation: Dept. of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: Storosum
authors.affiliation: Dept. of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: van den Brink
authors.affiliation: Medicines Evaluation Board, Utrecht, The Netherlands.
authors.forename: C C
authors.initials: CC
authors.lastname: Gispen-de Wied
authors.affiliation: Medicines Evaluation Board, Utrecht, The Netherlands.
authors.forename: H G M
authors.initials: HG
authors.lastname: Leufkens
authors.affiliation: Dept. of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
authors.forename: D A J P
authors.initials: DA
authors.lastname: Denys
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D014150:Antipsychotic Agents
keywords: Bipolar mania; Efficacy; Pharmacotherapy; Regulatory; Responder analysis