title: [Effect of Qi Benefiting Blood Activating Method on Plasma Fibrinogen and D-dimer in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease].
abstract: OBJECTIVE
  To explore the therapeutic effect of qi benefiting blood activating method (QB-BAM) on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with blood stasis syndrome (BSS) by observing its effect on plasma fibrinogen (Fg) and D-dimer (D-D) levels.
  
  
  METHODS
  Sixty AECOPD patients with BSS were randomly assigned to the treated group and the control group, 30 in each group. All patients received conventional therapy for AECOPD. Those in the treated group were additionally injected with Shengmai Injection and Tanshinone IIA Injection. Clinical efficacy and indices including levels of Fg, D-D, PaO2, and PaCO2 were measured and compared before and after treatment.
  
  
  RESULTS
  The effective rate was 93.3% (28/30 cases) in the treated group, higher than that of the control group [73.3% (22/30 cases) , P < 0.05]. There was no significant difference in all indices between the treated group and the control group before treatment (P >0.05). After treatment all indices were significantly improved in the two groups (P < 0.01). But in the treated group levels of Fg and D-D decreased more and levels of PaO2 increased more (P < 0.01). Plasma levels of Fg and D-D levels were negatively correlated with PaO2 (r = -0.493, r = -0.438, P < 0.01) before treatment, and also negatively correlated with PaO2 (r = -0.452, r = -0.325, P < 0.01, P < 0.05) after treatment, but they were not significantly correlated with PaCO2 before and after treatment (P >0.05).
  
  
  CONCLUSIONS
  QBBAM could play a therapeutic role in improving prethrombotic states of AECOPD patients with BSS. Plasma levels of Fg and D-D were related to the severity of AECOPD.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
authors.forename: Chun-dong
authors.initials: CD
authors.lastname: Zhu
authors.forename: Chun-ying
authors.initials: CY
authors.lastname: Li
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhou
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Ji
mesh_terms: D000208:Acute Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D006490:Hemostatics; D006801:Humans; D010949:Plasma; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D019413:Qi
chemical_list: D004365:Drugs, Chinese Herbal; D005338:Fibrin Fibrinogen Degradation Products; D006490:Hemostatics; C036309:fibrin fragment D; D005340:Fibrinogen