title: MicroRNAs in Cardiovascular Disease: Perspectives and Reality.
abstract: Since the discovery of the first noncoding RNA decades ago, the transcriptomics evolution has made a great leap reaching to the detection and recognition of microRNAs (miRNAs) in the early 1990s. Thereafter, numerous miRNAs were reported in different species, with a great body of literature focusing on their role in human health and in pathophysiological processes. miRNAs play a significant role in the cardiovascular system, not only in physiology and normal development but also in disease processes and evolution. Further studies on miRNAs have highlighted their participation in several expressions of cardiovascular disease, such as atherosclerosis, acute and chronic syndromes of coronary artery disease, heart failure, and cardiac arrhythmias. To date, the challenge remains to understand the underlying mechanisms of miRNAs that drive their expression profile so as to use them as innovative diagnostic tools or therapeutic targets in cardiovascular disease.
authors.affiliation: From the 1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papageorgiou
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tslamandris
authors.forename: Anastasios
authors.initials: A
authors.lastname: Giolis
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tousoulis
mesh_terms: D001161:Arteriosclerosis / Q000378:metabolism*; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D035683:MicroRNAs