title: Current and future molecular diagnostics in non-small-cell lung cancer.
abstract: The molecular investigation of lung cancer has opened up an advanced area for the diagnosis and therapeutic management of lung cancer patients. Gene alterations in cancer initiation and progression provide not only information on molecular changes in lung cancer but also opportunities in advanced therapeutic regime by personalized targeted therapy. EGFR mutations and ALK rearrangement are important predictive biomarkers for the efficiency of tyrosine kinase inhibitor treatment in lung cancer patients. Moreover, epigenetic aberration and microRNA dysregulation are recent advances in the early detection and monitoring of lung cancer. Although a wide range of molecular tests are available, standardization and validation of assay protocols are essential for the quality of the test outcome. In this review, current and new advancements of molecular biomarkers for non-small-cell lung cancer will be discussed. Recommendations on future development of molecular diagnostic services will also be explored.
authors.affiliation: Department of Health Technology and Informatics, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hong Kong Special Administrative Region, Hong Kong, China.
authors.forename: Chun Man
authors.initials: CM
authors.lastname: Li
authors.forename: Wing Ying
authors.initials: WY
authors.lastname: Chu
authors.forename: Di Lun
authors.initials: DL
authors.lastname: Wong
authors.forename: Hin Fung
authors.initials: HF
authors.lastname: Tsang
authors.forename: Nancy Bo Yin
authors.initials: NB
authors.lastname: Tsui
authors.forename: Charles Ming Lok
authors.initials: CM
authors.lastname: Chan
authors.forename: Vivian Wei Wen
authors.initials: VW
authors.lastname: Xue
authors.forename: Parco Ming Fai
authors.initials: PM
authors.lastname: Siu
authors.forename: Benjamin Yat Ming
authors.initials: BY
authors.lastname: Yung
authors.forename: Lawrence Wing Chi
authors.initials: LW
authors.lastname: Chan
authors.forename: Sze Chuen Cesar
authors.initials: SC
authors.lastname: Wong
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D025202:Molecular Diagnostic Techniques
chemical_list: D014408:Biomarkers, Tumor
keywords: ALK rearrangement; EGFR mutation; molecular diagnostics; non-small-cell lung cancer