title: 15 YEARS OF PARAGANGLIOMA: Pathology of pheochromocytoma and paraganglioma.
abstract: Pathologists using their routine diagnostic tools can contribute both to the care of patients with pheochromocytoma/paraganglioma and to understanding the pathobiology of the tumors. They can document details of tissue organization and cytology that are accessible only by microscopy and can characterize admixtures of cell types that are morphologically distinct or show differential expression of immunohistochemical markers. Current roles and challenges for pathologists include differential diagnosis, identifying clues to the presence of hereditary disease, and effective communication of pathology information for clinical and research purposes. Future roles will increasingly involve risk stratification, identification of actionable targets for personalized therapies, and aiding the interpretation of molecular tests by helping characterize genetic variants of unknown significance. It remains to be determined to what extent the need for pathology input will be overshadowed by the availability of genetic testing and other molecular analyses at ever-decreasing cost, together with very effective clinical paradigms for risk stratification and patient care.
authors.affiliation: Department of Pathology and Laboratory MedicineTufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USADepartment of PathologyErasmus MC University Medical Center, Rotterdam, The NetherlandsDepartment of PathologyReinier de Graaf Hospital, Delft, The Netherlands atischler@tuftsmedicalcenter.org.
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Tischler
authors.affiliation: Department of Pathology and Laboratory MedicineTufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USADepartment of PathologyErasmus MC University Medical Center, Rotterdam, The NetherlandsDepartment of PathologyReinier de Graaf Hospital, Delft, The Netherlands Department of Pathology and Laboratory MedicineTufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USADepartment of PathologyErasmus MC University Medical Center, Rotterdam, The NetherlandsDepartment of PathologyReinier de Graaf Hospital, Delft, The Netherlands.
authors.forename: Ronald R
authors.initials: RR
authors.lastname: deKrijger
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D010235:Paraganglioma / Q000235:genetics / Q000473:pathology*; D010673:Pheochromocytoma / Q000235:genetics / Q000473:pathology*
keywords: GAPP; PASS; histology; immunohistochemistry; pathology