title: Deciphering the genetic evolution of T-cell resistance in melanoma.
abstract: T-cell-based immunotherapy of melanoma becomes ineffective when β2m-deficient tumor cells of a human leukocyte antigen (HLA) class I-negative phenotype grow out. We demonstrated that an early-acquired chromosomal deletion and subsequent inactivating gene mutation lead to β2m deficiency, suggesting that melanoma cells can genetically evolve to avoid being recognized by CD8+T cells.
authors.affiliation: Department of Dermatology; University Hospital; University Duisburg-Essen and German Cancer Consortium (DKTK) ; Essen, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Sucker
authors.affiliation: Department of Dermatology; University Hospital; University Duisburg-Essen and German Cancer Consortium (DKTK) ; Essen, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Paschen
keywords: CD8+ T cells; HLA class I loss; genetic alterations; melanoma; β2m deficiency