title: A prospective clinical trial of radiofrequency ablation for pulmonary metastases.
abstract: Pulmonary oligometastases can be treated by local treatment options, such as resection, radiofrequency ablation (RFA), and radiotherapy, in selected patients. In the present study, 67 patients with 115 pulmonary metastases were treated, and all the lesions were treated by RFA and followed with a computed tomography scan. The local control, overall survival (OS), progression-free survival (PFS) and treatment-related toxicity were observed. Median follow-up duration after the initial RFA was 24 months (range, 3-39 months). The median PFS from RFA was 14 months [95% confidence interval (CI), 11.6-16.4]. The 6-, 12- and 18-month PFS rates were 82.1, 55.7 and 27.5%, respectively. The median OS rate from RFA was 24 months (95% CI, 18.2-29.8). The 1-, 2- and 3-year OS rates were 83.6, 46.3 and 14.3%, respectively. Primary tumor was significantly correlated to PFS and OS on multivariate analysis, and other variates showed no significance. Therefore, RFA is safe for patient treatment and can be considered as a promising treatment option for patients with pulmonary metastases.
authors.affiliation: Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China.
authors.forename: Yizong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China.
authors.forename: Xueguan
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Interventional Radiology, Qilu Hospital (Qingdao) of Shandong University, Qingdao, Shandong 266035, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
keywords: local tumor control; prognostic factors; pulmonary metastases; radiofrequency ablation