title: Riparin B, a Synthetic Compound Analogue of Riparin, Inhibits the Systemic Inflammatory Response and Oxidative Stress in Mice.
abstract: The aim of our study was to evaluate the anti-inflammatory, anti-nociceptive, and anti-oxidant action of Riparin B in vivo. We performed experiments in which we induced paw edema by carrageenan and other mediators, carrageenan-induced peritonitis and the level of myeloperoxidase (MPO) activity, pro-inflammatory cytokines (TNF-α and IL-1β), malondialdehyde (MDA) acid, and glutathione (GSH) from the peritoneal fluid. We also performed behavior tests such as acetic acid-induced writhing, formalin-induced linking, and the hot plate test. Among the doses tested of the Riparin B (1, 3, and 10 mg/kg), the dose of 10 mg/kg showed the strongest effect, and this dose was able to reduce the paw edema induced by carrageenan, dextran, histamine serotonin, bradykinin, 48/80, and PGE2. Similarly, the Riparin B in the same dose reduced cell migration and significantly decreased the nociception induced by formalin and acetic acid and reversed the parameters of the oxidative stress. Thus, we can infer that Riparin B exhibits anti-inflammatory, anti-nociceptive, and anti-oxidant actions in vivo.
authors.affiliation: LAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaíba, 64202-020, PI, Brazil.
authors.forename: Renata Fortes
authors.initials: RF
authors.lastname: Santiago
authors.affiliation: LAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaíba, 64202-020, PI, Brazil.
authors.forename: Tarcisio Vieira
authors.initials: TV
authors.lastname: de Brito
authors.affiliation: LAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaíba, 64202-020, PI, Brazil.
authors.forename: Jordana Maia
authors.initials: JM
authors.lastname: Dias
authors.affiliation: LAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaíba, 64202-020, PI, Brazil.
authors.forename: Genilson José
authors.initials: GJ
authors.lastname: Dias
authors.affiliation: LAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaíba, 64202-020, PI, Brazil.
authors.forename: José Simião
authors.initials: JS
authors.lastname: da Cruz
authors.affiliation: LAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaíba, 64202-020, PI, Brazil.
authors.forename: Jalles Arruda
authors.initials: JA
authors.lastname: Batista
authors.affiliation: LAFICA-Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, 60430-270, CE, Brazil.
authors.forename: Renan Oliveira
authors.initials: RO
authors.lastname: Silva
authors.affiliation: LAFICA-Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, 60430-270, CE, Brazil.
authors.forename: Marcellus H L P
authors.initials: MH
authors.lastname: Souza
authors.affiliation: LAFICA-Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, 60430-270, CE, Brazil.
authors.forename: Ronaldo
authors.initials: R
authors.lastname: de Albuquerque Ribeiro
authors.affiliation: Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piauí, Teresina, PI, Brazil.
authors.forename: Stanley Juan Chavez
authors.initials: SJ
authors.lastname: Gutierrez
authors.affiliation: Laboratory for Research in Experimental Neurochemistry, Campus Ministro Petrônio Portella, Federal University of Piauí, Teresina, PI, 64049550, Brazil.
authors.forename: Rivelilson M
authors.initials: RM
authors.lastname: Freitas
authors.affiliation: LAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaíba, 64202-020, PI, Brazil.
authors.forename: Jand-Venes R
authors.initials: JV
authors.lastname: Medeiros
authors.affiliation: LAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaíba, 64202-020, PI, Brazil. andreluiz@ufpi.edu.br.
authors.forename: André Luiz
authors.initials: AL
authors.lastname: Dos Reis Barbosa
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D002351:Carrageenan; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D005978:Glutathione / Q000378:metabolism; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D059226:Nociceptive Pain / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D018384:Oxidative Stress / Q000187:drug effects*; D010538:Peritonitis / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D009195:Peroxidase / Q000378:metabolism; D010627:Phenethylamines / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001549:Benzamides; D016207:Cytokines; D018836:Inflammation Mediators; C000609879:N-(2-(3,4-dimethoxyphenyl)ethyl)benzamide; D010627:Phenethylamines; D008315:Malondialdehyde; D002351:Carrageenan; D009195:Peroxidase; D005978:Glutathione
keywords: Riparin; anti-inflammatory; anti-nociceptive; anti-oxidant