title: Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding.
abstract: Osteopetrosis is a genetic disorder of bone remodeling caused by osteoclast dysfunction. Clinical features include short stature, frequent fractures, and recurrent infections. Abnormal bone obliterates the marrow cavity, resulting pancytopenia and extramedullary hematopoiesis in the liver and spleen. The splenomegaly can lead to left-sided portal hypertension. We report the second case of osteopetrosis-induced portal hypertension and the first case of upper gastrointestinal bleeding in a 52-year-old woman with osteopetrosis.
authors.affiliation: Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
authors.forename: Kristina N
authors.initials: KN
authors.lastname: Katz
authors.affiliation: Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Shafqet
authors.affiliation: Department of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
authors.forename: S Devi
authors.initials: SD
authors.lastname: Rampertab
authors.affiliation: Department of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
authors.forename: Nakechand
authors.initials: N
authors.lastname: Pooran