title: Impact of different controlled ovarian stimulation protocols on the physical and psychological burdens in women undergoing in vitro fertilization/intra cytoplasmic sperm injection.
abstract: BACKGROUND
  Infertility treatment involves a considerable amount of physical and psychological burden which may impact the outcome.
  
  
  OBJECTIVE
  The objective was to understand the amount of physical and psychological burden in women undergoing their first in vitro fertilization (IVF)/intra cytoplasmic sperm injection (ICSI) cycles.
  
  
  METHODS
  Multi-center, prospective, parallel, observational study.
  
  
  METHODS
  The study was conducted across 12 IVF centers in India. A total of 692 women undergoing controlled ovarian stimulation as a part of the first cycle IVF/ICSI completed the trial. Women were recruited in 2 groups based on type of treatment (Group A - gonadotropin-releasing hormone [GnRH] antagonist; Group B - GnRH agonist) and were asked to fill questionnaires during the 2 treatment visits.
  
  
  RESULTS
  The mean changes between Visit 1 (baseline) and Visit 2 in anxiety and depression (Hospital Anxiety and Depression Scale) scores in Group A for anxiety and depression were -0.5 (3.67), -0.1 (3.57) respectively and for Group B were -0.4 (3.68), 0.1 (3.67) respectively, which was not statistically significant. In Group A, the mean (±standard deviation [SD]) Hopkins Symptom Check List (HSCL) score was 17.9 (±5.17) in visit 1 and 19.1 (±5.45) Visit 2. The change between visits was 1.1 (P < 0.0001) with higher score reflecting higher somatic distress symptoms. In Group B, the mean (±SD) HSCL score was 18.2 (±5.19) in Visit 1 and 18.8 (±5.23) in visit 2. The change between visits was 0.6 (P < 0.0014). The difference of the mean change in physical burden between Group A and Group B was not statistically significant.
  
  
  CONCLUSIONS
  A significant impact in both treatment protocols with respect to the physical burden was found between Visit 1 and Visit 2 but no difference in physical or psychological burden between the two treatment groups was observed.
authors.affiliation: Medical Director, Infertility Institute and Research Center, Hyderabad, Telangana, India.
authors.forename: Deenadayal
authors.initials: D
authors.lastname: Mamata
authors.affiliation: Associate Director, Organon India Pvt. Ltd., Mumbai, Maharashtra, India.
authors.forename: Subrat K
authors.initials: SK
authors.lastname: Ray
authors.affiliation: Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Kumar
authors.initials: K
authors.lastname: Pratap
authors.affiliation: Director, Reproduction and Genetics at Jaslok Hospital, Mumbai, Maharashtra, India.
authors.forename: Parikh
authors.initials: P
authors.lastname: Firuza
authors.affiliation: Associate Director, Organon India Pvt. Ltd., Mumbai, Maharashtra, India.
authors.forename: Ashish Ramesh
authors.initials: AR
authors.lastname: Birla
authors.affiliation: Executive Director, Nova IVI Fertility Specialty, Ahmedabad, Gujarat, India.
authors.forename: Banker
authors.initials: B
authors.lastname: Manish
keywords: GnRH Agonist; GnRH Antagonist; In vitro fertilization; OHSS; physical and psychological burden