title: Controlling the Morphology of Organic Crystals with Filamentous Bacteriophages.
abstract: The preparation of thiamethoxam (TMX) organic crystals with high morphological uniformity was achieved by controlled aggregation-driven crystallization of primitive TMX crystals and phage using the filamentous M13 bacteriophage. The development of a regular, micrometer-sized, tetragonal-bipyramidal crystal structure was dependent on the amount of phage present. The phage appears to affect the supersaturation driving force for crystallization. The phage adsorption isotherm to TMX was well-fitted by the Satake-Yang model, which suggests a cooperative binding between neighboring phages as well as a binding of phage with the TMX crystal surface. This study shows the potential of phage additives to control the morphology and morphological uniformity of organic crystals.
authors.affiliation: †Department of Chemical and Biomolecular Engineering and Center for Molecular and Engineering Thermodynamics, University of Delaware, 150 Academy Street, Newark, Delaware 19716, United States.
authors.forename: Whirang
authors.initials: W
authors.lastname: Cho
authors.affiliation: ‡Syngenta Crop Protection 410 Swing Road, Greensboro, North Carolina 27409, United States.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: ‡Syngenta Crop Protection 410 Swing Road, Greensboro, North Carolina 27409, United States.
authors.forename: James
authors.initials: J
authors.lastname: Forrest
authors.affiliation: ‡Syngenta Crop Protection 410 Swing Road, Greensboro, North Carolina 27409, United States.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Fowler
authors.affiliation: †Department of Chemical and Biomolecular Engineering and Center for Molecular and Engineering Thermodynamics, University of Delaware, 150 Academy Street, Newark, Delaware 19716, United States.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Furst
mesh_terms: D017104:Bacteriophage M13 / Q000737:chemistry* / Q000648:ultrastructure*; D003460:Crystallization / Q000379:methods*; D017912:Inovirus / Q000737:chemistry / Q000648:ultrastructure; D008422:Materials Testing; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000737:chemistry*; D010078:Oxazines / Q000737:chemistry*; D013499:Surface Properties; D000077922:Thiamethoxam; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000073943:Neonicotinoids; D009574:Nitro Compounds; D010078:Oxazines; D013844:Thiazoles; D000077922:Thiamethoxam
keywords: M13 bacteriophage; Satake−Yang model adsorption isotherm; bioinspired crystallization; biointerfaces; thiamethoxam (TMX) organic crystals