title: A cyclodextrin-based polymer for sensing diclofenac in water.
abstract: An assay for the determination of diclofenac concentration, in the micromolar range in water, was developed. It is based on the use of a recently developed cyclodextrin-based polymer that possesses an inherent affinity for the target pharmaceutical. This competitive assay is exploiting the possibility to displace a fluorescent dye, adsorbed in the cyclodextrin-based polymer, by the target drug. This displacement is followed by measuring the increase in fluorescence polarization of the dye released in solution. The assay was successfully tested on a real wastewater sample with a limit of detection of 1 μM.
authors.affiliation: School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, New South Wales 2052, Australia. Electronic address: p.xiao@unsw.edu.au.
authors.forename: Pu
authors.initials: P
authors.lastname: Xiao
authors.affiliation: School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Weibel
authors.affiliation: INOFEA GmbH, Hochbergerstrasse 60c, CH-4057 Basel, Switzerland.
authors.forename: Yves
authors.initials: Y
authors.lastname: Dudal
authors.affiliation: School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, PR China.
authors.forename: Philippe F-X
authors.initials: PF
authors.lastname: Corvini
authors.affiliation: School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland. Electronic address: patrick.shahgaldian@fhnw.ch.
authors.forename: Patrick
authors.initials: P
authors.lastname: Shahgaldian
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D003505:Cyclodextrins / Q000737:chemistry*; D004008:Diclofenac / Q000032:analysis*; D005454:Fluorescence Polarization; D007700:Kinetics; D011108:Polymers / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D011108:Polymers; D014874:Water Pollutants, Chemical; D004008:Diclofenac
keywords: Cyclodextrin-based polymer; Diclofenac; Fluorescent polarization; Wastewater