title: Successful long-term ambulatory norepinephrine infusions in a patient with pure autonomic failure.
abstract: We present a case study of a patient with pure autonomic failure who was successfully treated with ambulatory norepinephrine (NE) infusions over a 9-year-period of time before death occurred unexpectedly. Given this patient's response to the NE infusion treatment, we discuss the option of ambulatory NE infusions as a treatment for severe orthostatic hypotension that is refractory to common treatments.
authors.affiliation: Nerve-Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital CHUV, Lausanne, Switzerland. Anastasia.zek@gmail.com.|Laboratory of Neuroimmunology, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA. Anastasia.zek@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Zekeridou
authors.affiliation: Nerve-Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital CHUV, Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Michel
authors.affiliation: Nerve-Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital CHUV, Lausanne, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Medlin
authors.affiliation: Department of Internal Medicine, Fribourg University Hospital, Fribourg, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Hayoz
authors.affiliation: Laboratory Medicine Service, Division of Neurology, Department of Clinical Neurosciences, Department of Genetic Medicine and Laboratory, Geneva University Hospital HUG, Geneva, Switzerland.
authors.forename: P H
authors.initials: PH
authors.lastname: Lalive
authors.affiliation: Nerve-Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital CHUV, Lausanne, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Kuntzer
mesh_terms: D000553:Ambulatory Care / Q000379:methods*; D017809:Fatal Outcome; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage*; D054970:Pure Autonomic Failure / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D009638:Norepinephrine
keywords: Norepinephrine infusions; PAF; Pure autonomic failure