title: Achromobacter xylosoxidans infection in an adult cystic fibrosis unit in Madrid.
abstract: BACKGROUND
  Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis (CF). Although the rate of colonization by this microorganism is variable, prevalence is increasing in CF units.
  
  
  METHODS
  A microbiological/clinical study was conducted on of adult CF patients harboring A. xylosoxidans. Identification and susceptibility testing were performed using MicroScan (Siemens). Decline in lung function was assessed using the variable, annual percentage loss of FEV1 (forced expiratory volume in 1s).
  
  
  RESULTS
  A. xylosoxidans was isolated in 18 (19.8%) of 91 patients over a 14-year period. Mean age was 26.6 years (18-39 years). Nine patients (9.8%) were chronically colonized. Piperacillin/tazobactam and imipenem were the most active antibiotics. Mean annual decline in lung function in chronically colonized patients was 2.49%.
  
  
  CONCLUSIONS
  A. xylosoxidans is a major pathogen in CF. A decreased lung function was observed among patients who were chronically colonized by A. xylosoxidans. Antibiotic therapy should be started early in order to prevent chronic colonization by this microorganism.
authors.affiliation: Department of Microbiology, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Diego de León, 62, Madrid, Spain. Electronic address: laurallorcaotero@gmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Llorca Otero
authors.affiliation: Department of Pulmonology, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Diego de León, 62, Madrid, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Girón Moreno
authors.affiliation: Department of Microbiology, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Diego de León, 62, Madrid, Spain.
authors.forename: Buenaventura
authors.initials: B
authors.lastname: Buendía Moreno
authors.affiliation: Department of Pulmonology, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Diego de León, 62, Madrid, Spain.
authors.forename: Claudia
authors.initials: C
authors.lastname: Valenzuela
authors.affiliation: Department of Microbiology, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Diego de León, 62, Madrid, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Guiu Martínez
authors.affiliation: Department of Microbiology, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Diego de León, 62, Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Alarcón Cavero
mesh_terms: D042441:Achromobacter denitrificans / Q000302:isolation & purification*; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D005541:Forced Expiratory Volume; D016905:Gram-Negative Bacterial Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Achromobacter xylosoxidans; Cystic fibrosis; Fibrosis quística; Función pulmonar; Lung function