title: High Peritoneal Glucose Exposure Is Associated with Increased Incidence of Relapsing and Recurrent Bacterial Peritonitis in Patients Undergoing Peritoneal Dialysis.
abstract: OBJECTIVE
  We investigated the association of peritoneal glucose exposure and dialysis exchange number with peritonitis outcome in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
  
  
  METHODS
  The first episodes of bacterial peritonitis were retrospectively analyzed in 187 CAPD patients. Peritoneal glucose exposure was calculated based on PD prescription at the onset of peritonitis.
  
  
  RESULTS
  Patients with peritoneal glucose exposure ≤140 g/day showed a higher and complete cure rate of peritonitis (66 vs. 51.7%, p = 0.047), lower occurrence of relapsing/recurrent peritonitis (10.0 vs. 21.8%, p = 0.026) and catheter removal (14.0 vs. 26.4%, p = 0.033). Patients who exchanged more than three times every day demonstrated marginally higher catheter removal rate (24.1 vs. 13.0%, p = 0.085). Logistic analysis indicated that peritoneal glucose exposure >140 g/day was an independent predictor for relapsing/recurrent peritonitis (RR: 1.959, p = 0.042).
  
  
  CONCLUSIONS
  High peritoneal glucose exposure is associated with increased incidence of relapsing/recurrent peritonitis in CAPD patients.
authors.affiliation: Department of Nephrology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, and Shanghai Center for Peritoneal Dialysis Research, Shanghai, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Jiang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Qian
authors.forename: Shan
authors.initials: S
authors.lastname: Mou
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ni
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005947:Glucose / Q000009:adverse effects; D015312:Hemodialysis Solutions / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000150:complications / Q000209:etiology / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000379:methods; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D010538:Peritonitis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D015312:Hemodialysis Solutions; D005947:Glucose