title: Lipid Peroxidation in a Stomach Medium Is Affected by Dietary Oils (Olive/Fish) and Antioxidants: The Mediterranean versus Western Diet.
abstract: Red meat is an integral part of the Western diet, and high consumption is associated with an increased risk of chronic diseases. Using a system that simulated the human stomach, red meat was interacted with different oils (olive/fish) and lipid peroxidation was determined by measuring accumulation of malondialdehyde (MDA) and lipid peroxides (LOOH). Olive oil decreased meat lipid peroxidation from 121.7 ± 3.1 to 48.2 ± 1.3 μM and from 327.1 ± 9.5 to 77.3 ± 6.0 μM as assessed by MDA and ROOH, respectively. The inhibitory effect of olive oil was attributed to oleic acid rather than its polyphenol content. In contrast, fish oils from tuna or an ω-3 supplement dramatically increased meat lipid peroxidation from 96.2 ± 3.6 to 514.2 ± 6.7 μM MDA. Vitamin E inhibited meat lipid peroxidation in the presence of olive oil but paradoxically increased peroxidation in the presence of fish oil. The inhibitory properties of oleic acid may play a key role in the health benefits of the Mediterranean diet.
authors.affiliation: Institute of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 76100, Israel.
authors.forename: Oren
authors.initials: O
authors.lastname: Tirosh
authors.affiliation: Institute of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 76100, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Shpaizer
authors.affiliation: Institute of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 76100, Israel.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kanner
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D038441:Diet, Mediterranean; D066273:Diet, Western; D004042:Dietary Fats, Unsaturated / Q000378:metabolism; D005395:Fish Oils / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D019301:Oleic Acid / Q000378:metabolism; D000069463:Olive Oil / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D008054:Lipid Peroxides; D000069463:Olive Oil; D019301:Oleic Acid; D008315:Malondialdehyde
keywords: antioxidants; fish oil; lipid peroxidation; olive oil; stomach medium