title: [Current and prospective issues about adult asthma].
abstract: The management of asthma treatment is likely to change in coming years, with the development of a more personalized approach. Biological therapies targeting Th2 cytokines (IL-4, IL-5 and IL-13) offer new treatment pathways for patients with severe asthma and high Th2 activity. Bronchial thermoplasty is the only treatment for severe asthma that could provide a long standing effect, but many questions still remain and its use is restricted to clinical research. Weight loss should be a goal during long-term management of obese asthmatics. Involvement of a new inflammatory pathway including IL-1 and IL-17 in a murine model of obesity and asthma may lead to new therapies in this subgroup of asthmatics.
authors.affiliation: Service de pneumologie et centre de compétence pour les maladies pulmonaires rares, hôpital Bichat, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors.forename: A
authors.initials: A
authors.lastname: Justet
authors.affiliation: Service de pneumologie et centre de compétence pour les maladies pulmonaires rares, hôpital Bichat, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors.forename: P
authors.initials: P
authors.lastname: Pradère
authors.affiliation: Service de pneumologie et centre de compétence pour les maladies pulmonaires rares, hôpital Bichat, 46, rue Henri-Huchard, 75877 Paris cedex 18, France. Electronic address: camille.taille@bch.aphp.fr.
authors.forename: C
authors.initials: C
authors.lastname: Taillé
mesh_terms: D000069594:Abatacept / Q000627:therapeutic use; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001249:Asthma / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D017075:Laser Coagulation / Q000009:adverse effects / Q000379:methods; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009765:Obesity / Q000150:complications / Q000628:therapy; D035703:Therapies, Investigational / Q000009:adverse effects / Q000639:trends
chemical_list: D018927:Anti-Asthmatic Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C582203:dupilumab; D000069594:Abatacept
keywords: Anticorps monoclonal; Asthma; Asthme; Monoclonal antibody; Obesity; Obésité; Thermoplastie; Thermoplasty