title: Hematochezia Associated with Sevalamer-Induced Mucosal Injury.
abstract: We present a case of a 61-year-old woman with end-stage renal disease (ESRD) who developed painless hematochezia following initiation of anticoagulation. Work-up revealed a large ulceration in the sigmoid colon, and histologic images revealed sevelamer crystals embedded in the colonic mucosa, consistent with sevelamer crystal-mediated injury. This is a novel cause of gastrointestinal hemorrhage that has not previously been described in the literature. Physicians should be aware of the potential for sevelamer-induced injury.
authors.affiliation: Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Preethi
authors.initials: P
authors.lastname: Chintamaneni
authors.affiliation: Department of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Rohit
authors.initials: R
authors.lastname: Das
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Shih-Fan
authors.initials: SF
authors.lastname: Kuan
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Taher R
authors.initials: TR
authors.lastname: Kermanshahi
authors.affiliation: Department of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Jana G
authors.initials: JG
authors.lastname: Hashash