title: Fluorinated and Un-fluorinated N-halamines as Antimicrobial and Biofilm-controlling Additives for Polymers.
abstract: The objective of this study was to evaluate the effects of fluorination on the antimicrobial and biofilm-controlling activities of N-halamine-based additives for polymers. A fluorinated N-halamine, 1-chloro-3-1H,1H,2H,2H-perflurooctyl-5,5-dimetylhydantoin (Cl-FODMH), and its un-fluorinated counterpart, 1-chloro-3-octyl-5,5-dimethylhydantoin (Cl-ODMH), were synthesized and characterized with FT-IR,1H-NMR, and DSC studies. Polyurethane (PU) films containing Cl-ODMH and Cl-FODMH as antimicrobial additives were fabricated through solvent casting. With the same additive contents (1wt%-5 wt%), PU films with Cl-FODMH showed higher contact angle values. AFM, SEM and DSC results revealed that while Cl-ODMH distributed evenly within PU, Cl-FODMH aggregated and formed macro-domains in PU. Antimicrobial studies showed that PU films with Cl-ODMH had higher antimicrobial and biofilm-controlling potency against Gram-positive and Gram-negative bacteria than PU samples with Cl-FODMH. These results demonstrated the importance of distribution of additives in polymers on antimicrobial performances, shedding lights on future antimicrobial material design strategies.
authors.affiliation: Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854.
authors.forename: Jiajin
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854.
authors.forename: Fuguang
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854.
authors.forename: Jianchuan
authors.initials: J
authors.lastname: Wen
authors.affiliation: Biomedical Engineering Program, University of South Dakota, Sioux Falls, SD 57107.
authors.forename: Wei
authors.initials: W
authors.lastname: Lv
authors.affiliation: Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-4404.
authors.forename: Nuala
authors.initials: N
authors.lastname: Porteous
authors.affiliation: Biomedical Engineering Program, University of South Dakota, Sioux Falls, SD 57107.
authors.forename: Ying
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854.
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Sun