title: Genetic Polymorphisms Might Predict Suicide Attempts in Mental Disorder Patients: A Systematic Review And Meta-Analysis.
abstract: The aim of the present study was to analyze if the genetic polymorphisms might predict suicide attempts in mental disorder patients. The literature review and meta-analysis were conducted using the PubMed/Medline, Web of science and Scopus database using the terms: "5-HTT or SLC6A4 or 5-SERT and suicide, suicidal ideation or suicidal behavior or suicidal attempt". Thirty articles were analyzed. We found 17 articles that showed association and 13 articles that showed no association between LPR serotonin transporter polymorphism and suicide. A higher study of suicide identified the serotonin transporter polymorphism in patients with schizophrenia, mental disorder, major depression and bipolar disorder. There is an association between the serotonin-transporter-linked polymorphic region and suicidal behavior. The mental disorders with greater relationship with the suicide were the bipolar disorder, major depression and schizophrenia. The L allele had higher risk for suicide.
authors.affiliation: Federal University of Alagoas, Alagoas, Brazil. veronica.ufal.arapiraca@gmail.com.
authors.forename: Veronica
authors.initials: V
authors.lastname: de Medeiros Alves
authors.forename: Daniele Goncalves
authors.initials: DG
authors.lastname: Bezerra
authors.forename: Tiago Gomes
authors.initials: TG
authors.lastname: de Andrade
authors.forename: Valfrido Leao
authors.initials: VL
authors.lastname: de Melo Neto
authors.forename: Antonio E
authors.initials: AE
authors.lastname: Nardi
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013406:Suicide, Attempted; D044465:White People / Q000235:genetics / Q000523:psychology
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins