title: In Vitro Efficacy of Antiviral Compounds against Enterovirus D68.
abstract: In 2014, the United States experienced a large outbreak of severe respiratory illness associated with enterovirus D68 (EV-D68). We used a homogeneous, cell-based assay to assess the antiviral activity of compounds developed for EV/rhinovirus infection or other indications. Three of 15 compounds were highly active against all four strains tested (the prototype and three 2014 strains), with 50% effective concentrations of 0.0012 to 0.027 μM. Additional studies are needed to assess their in vivo efficacy against EV-D68.
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Rhoden
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Immunization Planning Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, China.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: W Allan
authors.initials: WA
authors.lastname: Nix
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA soberste@cdc.gov.
authors.forename: M Steven
authors.initials: MS
authors.lastname: Oberste
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002213:Capsid / Q000187:drug effects; D004196:Disease Outbreaks; D030016:Enterovirus D, Human / Q000187:drug effects*; D004769:Enterovirus Infections / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011480:Protease Inhibitors / Q000494:pharmacology; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000821:virology
chemical_list: D000998:Antiviral Agents; D011480:Protease Inhibitors