title: Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease.
abstract: Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. Various therapeutic approaches are being used to improve the cholinergic neurotransmission, but their role in AD pathogenesis is still unknown. Although, an increase in tau protein concentration in CSF has been described in AD, but several issues remains unclear. Extensive and accurate analysis of CSF could be helpful to define presence of tau proteins in physiological conditions, or released during the progression of neurodegenerative disease. The amyloid cascade hypothesis postulates that the neurodegeneration in AD caused by abnormal accumulation of amyloid beta (Aβ) plaques in various areas of the brain. The amyloid hypothesis has continued to gain support over the last two decades, particularly from genetic studies. Therefore, current research progress in several areas of therapies shall provide an effective treatment to cure this devastating disease. This review critically evaluates general biochemical and physiological functions of Aβ directed therapeutics and their relevance.
authors.affiliation: Department of Biotechnology, Shivaji University, Kolhapur 416004, Maharashtra (M.S.), India.
authors.forename: Sagar H
authors.initials: SH
authors.lastname: Barage
authors.affiliation: Structural Bioinformatics Unit, Department of Biochemistry, Shivaji University, Kolhapur 416004, Maharashtra (M.S.), India; Department of Microbiology, Shivaji University, Kolhapur 416004, Maharashtra (M.S.), India. Electronic address: kds_biochem@unishivaji.ac.in.
authors.forename: Kailas D
authors.initials: KD
authors.lastname: Sonawane
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016874:Neurofibrillary Tangles / Q000378:metabolism; D015398:Signal Transduction; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; C054369:MAPT protein, human; D016875:tau Proteins; D000109:Acetylcholine
keywords: AD genetics; Alzheimer's disease; Amyloid based therapies; Amyloid cascade hypothesis; Aβ degrading enzyme; Neuropeptides