title: Breaking the Barrier--Chaperone-Mediated Autophagy of Perilipins Regulates the Lipolytic Degradation of Fat.
abstract: Triglyceride hydrolysis by cytosolic and lysosomal lipases mobilizes fatty acids from lipid droplet stores. Kaushik and Cuervo (2015) found that chaperone-mediated autophagy removes the protective barrier from the lipid droplet surface, facilitating lipolysis by cytosolic lipases and assembly of autolipophagosomes for subsequent lysosomal lipid degradation.
authors.affiliation: Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.
authors.forename: Martina
authors.initials: M
authors.lastname: Schweiger
authors.affiliation: Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria. Electronic address: rudolf.zechner@uni-graz.at.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Zechner
mesh_terms: D000818:Animals; D001343:Autophagy; D066292:Lipid Droplets / Q000378:metabolism*; D008066:Lipolysis; D008099:Liver / Q000378:metabolism*; D008297:Male; D018832:Molecular Chaperones / Q000378:metabolism*
chemical_list: D018832:Molecular Chaperones