title: Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases.
abstract: Emerging evidence reveals that various cytokines and tissue microenvironments contribute to liver inflammation and autoimmunity, and IL-17 family is one of highlights acknowledged. Although the implication of IL-17 family in most common autoimmune diseases (such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis) has been extensively characterized, the role of this critical family in pathophysiology of autoimmune liver diseases (AILD) still needs to be clarified. In the review, we look into the intriguing biology of IL-17 family and further dissect on the intricate role of IL-17-mediated pathway in AILD. Considering encouraging data from preclinical and clinical trials, IL-17 targeted therapy has shown promises in several certain autoimmune conditions. However, blocking IL-17-mediated pathway is just beginning, and more fully investigation and reflection are required. Taking together, targeting IL-17-mediated responses may open up new areas of potential clinical treatment for AILD.
authors.affiliation: Liver Unit and Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, 20089 Milan, Italy ; State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Liver Unit and Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bernuzzi
authors.affiliation: Liver Unit and Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
authors.forename: Ana
authors.initials: A
authors.lastname: Lleo
authors.affiliation: State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Liver Unit and Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Invernizzi
mesh_terms: D001327:Autoimmune Diseases / Q000209:etiology / Q000628:therapy*; D015209:Cholangitis, Sclerosing / Q000209:etiology / Q000628:therapy; D019693:Hepatitis, Autoimmune / Q000209:etiology / Q000628:therapy; D006801:Humans; D020381:Interleukin-17 / Q000037:antagonists & inhibitors* / Q000502:physiology; D008105:Liver Cirrhosis, Biliary / Q000209:etiology / Q000628:therapy; D008107:Liver Diseases / Q000209:etiology / Q000628:therapy*; D053722:Receptors, Interleukin-17 / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17