title: Acid Suppressive Therapy for Stress Ulcer Prophylaxis in Noncritically Ill Patients.
abstract: BACKGROUND
  The current literature discourages the use of acid suppressive therapy (AST) for stress ulcer prophylaxis (SUP) in noncritically ill patients. However, several sources indicate that the majority of noncritically ill patients are given AST for SUP while there may only be a small proportion of high-risk patients who need SUP therapy. There is a new scoring system to aid practitioners in stratifying the risk of stress ulcer-related gastrointestinal bleeding in noncritically ill patients developed by Herzig et al and appropriately prescribe AST for SUP in this population.
  
  
  OBJECTIVE
  Our primary objective was to determine the current usage of AST in noncritically ill patients at a tertiary teaching hospital and use the new scoring system to identify non-intensive care unit patients who were inappropriately given AST.
  
  
  METHODS
  We retrospectively determined the percentage of noncritically ill patients who were given AST on medical floors between January 2010 and December 2012. After identifying these patients, we randomly selected a sample and retrospectively collected data from their medical record to determine the gastrointestinal bleeding risk score to determine if the patient was appropriately given AST.
  
  
  RESULTS
  Of the 42 600 admissions, 22 949 (53.7%) noncritically ill patients were given AST. A total of 442 patients were randomly selected for data collection and 156 patients were excluded. Gastrointestinal bleeding risk score was calculated in 286 patients. This new risk stratification tool identified 253 (88.5%) patients to have a low (≤7) and low-medium risk score (8-9).
  
  
  CONCLUSIONS
  A large percentage of noncritically ill patients were given AST during their hospital stay; 88.5% of these medications were given inappropriately to patients who were at extremely low risk of gastrointestinal bleeding. Using the above information and the AST prescribing patterns at our institution, we estimate a potential inpatient medication cost savings of $114 622 for the study period.
authors.affiliation: Medical Center Hospital, Odessa, TX, USA Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Minh T
authors.initials: MT
authors.lastname: Hong
authors.affiliation: Medical Center Hospital, Odessa, TX, USA Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Leslie C
authors.initials: LC
authors.lastname: Monye
authors.affiliation: Texas Tech University Health Sciences Center, Lubbock, TX, USA charles.seifert@ttuhsc.edu.
authors.forename: Charles F
authors.initials: CF
authors.lastname: Seifert
mesh_terms: D000328:Adult; D000368:Aged; D017046:Cost Savings; D016527:Drug Costs; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000191:economics / Q000209:etiology / Q000517:prevention & control; D006635:Histamine H2 Antagonists / Q000191:economics / Q000627:therapeutic use; D006760:Hospitalization; D006784:Hospitals, Teaching; D006801:Humans; D007297:Inpatients; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000191:economics / Q000209:etiology / Q000517:prevention & control*; D054328:Proton Pump Inhibitors / Q000191:economics / Q000627:therapeutic use; D012189:Retrospective Studies; D012306:Risk; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000150:complications; D062606:Tertiary Care Centers; D014456:Ulcer
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
keywords: acid suppressive therapy; histamine type 2 antagonists; inpatients; proton pump inhibitors; stress ulcer prophylaxis