title: The UCLA Study of Children with Moderate-to-Severe Traumatic Brain Injury: Event-Related Potential Measure of Interhemispheric Transfer Time.
abstract: Traumatic brain injury (TBI) frequently results in diffuse axonal injury and other white matter damage. The corpus callosum (CC) is particularly vulnerable to injury following TBI. Damage to this white matter tract has been associated with impaired neurocognitive functioning in children with TBI. Event-related potentials can identify stimulus-locked neural activity with high temporal resolution. They were used in this study to measure interhemispheric transfer time (IHTT) as an indicator of CC integrity in 44 children with moderate/severe TBI at 3-5 months post-injury, compared with 39 healthy control children. Neurocognitive performance also was examined in these groups. Nearly half of the children with TBI had IHTTs that were outside the range of the healthy control group children. This subgroup of TBI children with slow IHTT also had significantly poorer neurocognitive functioning than healthy controls-even after correction for premorbid intellectual functioning. We discuss alternative models for the relationship between IHTT and neurocognitive functioning following TBI. Slow IHTT may be a biomarker that identifies children at risk for poor cognitive functioning following moderate/severe TBI.
authors.affiliation: 1 Department of Psychiatry and Biobehavioral Sciences, University of California , Los Angeles, Los Angeles, California.|2 Fuller Graduate School of Psychology , Pasadena, California.
authors.forename: Monica U
authors.initials: MU
authors.lastname: Ellis
authors.affiliation: 2 Fuller Graduate School of Psychology , Pasadena, California.
authors.forename: Sarah
authors.initials: S
authors.lastname: DeBoard Marion
authors.affiliation: 3 Department of Neurosurgery, University of California , Los Angeles, Los Angeles, California.
authors.forename: David L
authors.initials: DL
authors.lastname: McArthur
authors.affiliation: 1 Department of Psychiatry and Biobehavioral Sciences, University of California , Los Angeles, Los Angeles, California.|4 Mattel Children's Hospital, University of California , Los Angeles, Los Angeles, California.
authors.forename: Talin
authors.initials: T
authors.lastname: Babikian
authors.affiliation: 3 Department of Neurosurgery, University of California , Los Angeles, Los Angeles, California.|4 Mattel Children's Hospital, University of California , Los Angeles, Los Angeles, California.|5 Steve Tisch BrainSPORT Program, University of California , Los Angeles, Los Angeles, California.|6 Brain Injury Research Center, University of California , Los Angeles, Los Angeles, California.|7 Department of Pediatrics, University of California , Los Angeles, Los Angeles, California.
authors.forename: Christopher
authors.initials: C
authors.lastname: Giza
authors.affiliation: 1 Department of Psychiatry and Biobehavioral Sciences, University of California , Los Angeles, Los Angeles, California.|4 Mattel Children's Hospital, University of California , Los Angeles, Los Angeles, California.
authors.forename: Claudia L
authors.initials: CL
authors.lastname: Kernan
authors.affiliation: 1 Department of Psychiatry and Biobehavioral Sciences, University of California , Los Angeles, Los Angeles, California.
authors.forename: Nina
authors.initials: N
authors.lastname: Newman
authors.affiliation: 1 Department of Psychiatry and Biobehavioral Sciences, University of California , Los Angeles, Los Angeles, California.|4 Mattel Children's Hospital, University of California , Los Angeles, Los Angeles, California.
authors.forename: Lisa
authors.initials: L
authors.lastname: Moran
authors.affiliation: 8 Wayne State University School of Medicine , Detroit, Michigan.
authors.forename: Roy
authors.initials: R
authors.lastname: Akarakian
authors.affiliation: 1 Department of Psychiatry and Biobehavioral Sciences, University of California , Los Angeles, Los Angeles, California.
authors.forename: Asal
authors.initials: A
authors.lastname: Houshiarnejad
authors.affiliation: 7 Department of Pediatrics, University of California , Los Angeles, Los Angeles, California.|9 Harbor-University of California , Los Angeles Medical Center, Torrance, California.
authors.forename: Richard
authors.initials: R
authors.lastname: Mink
authors.affiliation: 10 Department of Clinical Pediatrics, University of Southern California ; Department of Pediatrics, Los Angeles County+USC Medical Center, Los Angeles, California.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Johnson
authors.affiliation: 11 Department of Pediatrics, Miller Children's Hospital , Long Beach, California.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Babbitt
authors.affiliation: 1 Department of Psychiatry and Biobehavioral Sciences, University of California , Los Angeles, Los Angeles, California.|12 Alexander Olsen Department of Psychology, Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital , Trondheim, Norway .
authors.forename: Alexander
authors.initials: A
authors.lastname: Olsen
authors.affiliation: 1 Department of Psychiatry and Biobehavioral Sciences, University of California , Los Angeles, Los Angeles, California.|13 Department of Psychology, University of California , Los Angeles, Los Angeles, California.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Asarnow
mesh_terms: D000293:Adolescent; D000070642:Brain Injuries, Traumatic / Q000150:complications / Q000503:physiopathology*; D002648:Child; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D015599:Trauma Severity Indices
keywords: corpus callosum; event-related potential; interhemispheric transfer time; neurocognitive functioning; pediatric traumatic brain injury