title: [Diagnosis and treatment of aspirin--and NSAID-induced peptic ulcers].
abstract: A Japanese case-control study showed the odds ratio of upper gastrointestinal bleeding was 5.5 for aspirin and 6.1 for other NSAIDs. A Japanese cohort study showed that peptic ulcers were found in 6.5% of 1,454 patients receiving low-dose aspirin (LDA). Some endoscopic studies reported that NSAID users often had antral, multiple, and irregular ulcers, irrespective of Helicobacter pylori status. Proton-pump inhibitor (PPI) and misoprostol should be used for therapy for NSAID-ulcers. Maintenance therapy with PPI should be given for prevention of relapse of ulcers of NSAIDs and LDA users. PPI and histamine 2-recetor antagonist were effective for prevention of upper GI mucosal injury in patients receiving LDA.
authors.forename: Kiichi
authors.initials: K
authors.lastname: Satoh
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanabe
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Ichiishi
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Ando
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy* / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D012008:Recurrence
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin