title: Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis.
abstract: BACKGROUND
  The cervical lymph node metastasis (CLNM) of papillary thyroid microcarcinoma (PTMC) is not uncommon. However, prophylactic cervical lymph node dissection in all PTMC is debatable. Molecular markers of predicting CLNM would help to decide to either do or not do cervical lymph node dissection which might increase morbidities.
  
  
  OBJECTIVE
  We aimed to characterize gene expression profiles and molecular markers of CLNM in PTMC.
  
  
  METHODS
  The thyroid frozen tissues were obtained with from six PTMC patients, who underwent total thyroidectomy.
  
  
  METHODS
  We performed oligonucleotide microarray analysis with three PTMCs with CLNM and three without CLNM. Real-time quantitative reverse transcription-polymerase chain reaction was used to validate the gene.
  
  
  METHODS
  We used linear models for microarray data.
  
  
  RESULTS
  We identified 12 differentially expressed gene, and most one is endoplasmic reticulum aminopeptidase 2 (ERAP2).
  
  
  CONCLUSIONS
  ERAP2 might be associated with CLNM in PTMC.
authors.forename: Woo Young
authors.initials: WY
authors.lastname: Kim
authors.affiliation: Department of Surgery, Korea University College of Medicine, Guro Hospital, Seoul, Korea.
authors.forename: Jae Bok
authors.initials: JB
authors.lastname: Lee
authors.forename: Hoon Yub
authors.initials: HY
authors.lastname: Kim
authors.forename: Sang Uk
authors.initials: SU
authors.lastname: Woo
authors.forename: Gil Soo
authors.initials: GS
authors.lastname: Son
authors.forename: Jeoung Won
authors.initials: JW
authors.lastname: Bae
mesh_terms: D000626:Aminopeptidases / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology; D059467:Transcriptome / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D000626:Aminopeptidases; C503944:ERAP2 protein, human