title: Oleuropein-Rich Diet Attenuates Hyperglycemia and Impaired Glucose Tolerance in Type 2 Diabetes Model Mouse.
abstract: Oleuropein, a phenolic compound found in abundance in olive leaves, has beneficial effects on various diseases. However, it is unknown whether an oleuropein-rich diet is efficacious against type 2 diabetic phenotypes. In this study, we investigated the effects of the oleuropein-containing supplement OPIACE, whose oleuropein content exceeds 35% (w/w), on the diabetic phenotypes in type 2 diabetes model Tsumura Suzuki Obese Diabetes (TSOD) mouse. TSOD mice were fed OPIACE at 4 weeks of age, i.e., before the TSOD mice exhibited diabetic phenotypes. We revealed that OPIACE attenuated hyperglycemia and impaired glucose tolerance in TSOD mice over the long-term (from 10 to 24 weeks of age) but had no effect on obesity. Furthermore, we demonstrated that OPIACE mildly reduced oxidative stress in TSOD mice by 26.2% and attenuated anxiety-like behavioral abnormality in aged TSOD mice. The results suggest that oleuropein suppresses the progression of type 2 diabetes and diabetes-related behavioral abnormality over the long-term.
authors.affiliation: †Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan.
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Murotomi
authors.affiliation: †Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Umeno
authors.affiliation: †Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan.
authors.forename: Mayu
authors.initials: M
authors.lastname: Yasunaga
authors.affiliation: ‡Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577, Japan.
authors.forename: Mototada
authors.initials: M
authors.lastname: Shichiri
authors.affiliation: ‡Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Ishida
authors.forename: Taisuke
authors.initials: T
authors.lastname: Koike
authors.forename: Toshiki
authors.initials: T
authors.lastname: Matsuo
authors.affiliation: †Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Abe
authors.affiliation: †Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan.
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: †Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000378:metabolism; D004032:Diet; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000178:diet therapy*; D057888:Iridoid Glucosides; D039823:Iridoids / Q000378:metabolism*; D008297:Male; D051379:Mice; D008820:Mice, Obese
chemical_list: D001786:Blood Glucose; D057888:Iridoid Glucosides; D039823:Iridoids; C002769:oleuropein
keywords: anxiety; hyperglycemia; impaired glucose tolerance; oleuropein; type 2 diabetes