title: Impact of APEX Ile64val Gene Polymorphisms of DNA Repair Ber System on Modulation of the Risk of Colorectal Cancer in the Polish Population.
abstract: Colorectal cancer (CRC) is one of the deadliest cancers which lie in the incidence of morbidity in second place. Intensive research is to determine and confirm the genetic basis of this disease, which is believed may have a direct relationship with the reduced efficiency of DNA repair systems. The aim of this study was to determine the effect of APEX gene polymorphism Ile64Val on increasing the risk of colorectal cancer in the Polish population.
  
  
  METHODS
  The blood samples collected from 150 patients diagnosed with colon cancer was used. The control group consisted of 150 healthy subjects. Genotyping was performed by TaqMan method.
  
  
  RESULTS
  The results indicate that genotype Ile Val is associated with an increased risk of colorectal cancer (OR 2.069; 95% CI 1,205-3,552; p = 0.008).
  
  
  CONCLUSIONS
  Based on these results, we conclude that the APEX gene polymorphism Ile64Val may be associated with an increased risk of colorectal cancer.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kabziński
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Majsterek
authors.forename: Michał
authors.initials: M
authors.lastname: Mik
authors.forename: Adam
authors.initials: A
authors.lastname: Dziki
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Dziki
authors.forename: Lucjan
authors.initials: L
authors.lastname: Maciejczak
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics*; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D045643:DNA Repair Enzymes