title: Renal mineralocorticoid receptor and electrolyte homeostasis.
abstract: The renal mineralocorticoid receptor (MR) is a steroid hormone receptor essential for maintaining electrolyte homeostasis. Its role in mediating effects of aldosterone was likely vital in enabling the evolution of terrestrial life. Dysregulated aldosterone-MR signaling has been identified as the cause of multiple clinical diseases, suggesting the physiological importance of the MR. While the physiology of this pathway has been studied for over 60 years, only more recently have genetic mouse models been available to dissect its function in vivo. This review will focus on recent advances in our knowledge of MR function with an emphasis on these models.
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon; and.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Terker
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon; and Veteran Affairs Portland Health Care System, Portland, Oregon ellisond@ohsu.edu.
authors.forename: David H
authors.initials: DH
authors.lastname: Ellison
mesh_terms: D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D007668:Kidney / Q000502:physiology*; D008954:Models, Biological; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism*; D018161:Receptors, Mineralocorticoid; D014882:Water-Electrolyte Balance
chemical_list: D015221:Potassium Channels; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone; D011188:Potassium
keywords: Na+ Cl− cotransporter; homeostasis; mineralocorticoid; potassium; sodium