title: [1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and  cognitive dysfunction].
abstract: OBJECTIVE
  To detect metabolic changes of bilateral frontal lobe in patients with multiple system atrophy (MSA) and cognitive dysfunction by 1H-proton magnetic resonance spectroscopy (1H-MRS).
  
  
  METHODS
  N-acetylaspartate (NAA)/creatine(Cr), choline (Cho)/Cr, myoinositol (mI)/Cr in three sides of frontal lobe were detected by 1H-MRS in 48 healthy controls, 23 patients with MSA and cognitive dysfunction and 19 patients with MSA but without cognitive dysfunction.
  
  
  RESULTS
  NAA/Cr of bilateral frontal lobes in patients with MSA and cognitive dysfunction was significantly decreased compared with MSA patients without cognitive dysfunction and healthy controls (P<0.05). mI/Cr of right frontal lobes was significantly increased in patients with MSA and cognitive dysfunction compared with healthy controls (P<0.05). There was a negative correlation between NAA/Cr of bilateral frontal lobes and duration while a positive correlation between NAA/Cr of bilateral frontal lobes and MoCA score in patients with MSA and cognitive dysfunction.
  
  
  CONCLUSIONS
  There is a decrease in NAA/Cr and an increase in mI/Cr in frontal lobes in patients with MSA and cognitive dysfunction, which may be associated with cognitive dysfunction in MSA patients.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008;Department of Neurology, Xiangxi Autonomous Prefecture People's Hospital, Jishou Hunan 416000, China.
authors.forename: Xiaoshuang
authors.initials: X
authors.lastname: Xiang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Zhanfang
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Gaofeng
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008.
authors.forename: Beisha
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003072:Cognition Disorders / Q000503:physiopathology*; D003401:Creatine / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000378:metabolism; D019578:Multiple System Atrophy / Q000503:physiopathology*; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline