title: Characterization of nonmelanoma skin cancer for light therapy using spatial frequency domain imaging.
abstract: The dosimetry of light-based therapies critically depends on both optical and vascular parameters. We utilized spatial frequency domain imaging to quantify optical and vascular parameters, as well as estimated light penetration depth from 17 nonmelanoma skin cancer patients. Our data indicates that there exist substantial spatial variations in these parameters. Characterization of these parameters may inform understanding and optimization of the clinical response of light-based therapies.
authors.affiliation: Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rohrbach
authors.affiliation: Department of Dermatology, University of Arizona Cancer Center, Tucson, AZ, USA.
authors.forename: Nathalie C
authors.initials: NC
authors.lastname: Zeitouni
authors.affiliation: Department of Electrical Engineering, University at Buffalo, Buffalo, NY, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Muffoletto
authors.affiliation: Beckman Laser Institute, University of California Irvine, Irvine, CA, USA.
authors.forename: Rolf
authors.initials: R
authors.lastname: Saager
authors.affiliation: Beckman Laser Institute, University of California Irvine, Irvine, CA, USA.
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Tromberg
authors.affiliation: Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA ; Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA.
authors.forename: Ulas
authors.initials: U
authors.lastname: Sunar
keywords: (110.4234) Multispectral and hyperspectral imaging; (170.0110) Imaging systems; (170.1870) Dermatology; (170.6935) Tissue characterization