title: [The availability of prostaglandin derivatives in a treatment and prevention for gastrointestinal mucosal injury].
abstract: Prostaglandins play important roles in the gastric mucosal protection and gastric ulcer healing. Administration of the prostaglandin derivatives has been proven to be effective for both treatment and prevention of gastric ulcers associated with non-steroidal anti-inflammatory drugs (NSAIDs). The risk of postoperative hemorrhage following gastric endoscopic submucosal dissection (ESD) is higher in patients with antithrombotic therapy. Mucosal protective agents, including prostaglandin derivatives, may be effective in preventing post-ESD hemorrhage in patients on antithrombotic therapy. Recently, NSAIDs-induced small intestinal damages are recognized by video capsule endoscopy and balloon endoscopy. Prostaglandin derivatives are also useful for these small intestinal damages.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Harada
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Shoko
authors.initials: S
authors.lastname: Edogawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ota
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kojima
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Higuchi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects; D005753:Gastric Mucosa / Q000187:drug effects* / Q000293:injuries; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000293:injuries; D011453:Prostaglandins / Q000737:chemistry / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins