title: Hypothesizing repetitive paraphilia behavior of a medication refractive Tourette's syndrome patient having rapid clinical attenuation with KB220Z-nutrigenomic amino-acid therapy (NAAT).
abstract: Background and aims Many patients presenting multiple behaviors including drug and food abuse as well as other pathological repetitive unwanted activities such as gambling, self-mutilation and paraphilias may not be appropriately diagnosed. Here we present a case of a male presenting many of these seemingly diverse behaviors and finally diagnosed with reward deficiency syndrome (RDS) by his attending physician. Methods The use of the dopamine agonist, ropinirole after two weeks showed improvement in terms of sexual behavior but tolerance set in and was discontinued especially when an infraction occurred with the patient's insurance. In this article, we carefully explore the potential of ropinirole to downregulate dopamine receptors causing adenylate cyclase receptor supersensitivity and tolerance a feature of neurotransmitter cross-talk. Based on previous scientific evidence showing KB220Znutrigenomic amino-acid therapy (NAAT) to rapidly (post one-hour) activate dopaminergic pathways in both the pre-frontal cortex cingulate gyrus (relapse loci) and ventral tegmental area-caudate-accumbens-putamen (craving and emotion loci) the patient was prescribed NAAT. Results and discussion Within one week of utilization the repetitive paraphilia was eliminated. There were also a number of other positive effects such as enhanced focus that persisted even after the patient stopped using KB220Z suggesting neuroplasticity (e.g. altruistic thoughts). However, these observed profound benefits require more in-depth study, especially in a large cohort against a placebo. While this report focused on a rapid response rather than long-term benefits previously associated with NAAT, it is somewhat encouraging and longer term required follow-up and larger placebo controlled studies are warranted before any definitive conclusions could be gleaned from this case report.
authors.forename: Thomas
authors.initials: T
authors.lastname: Mclaughlin
authors.forename: Marlene
authors.initials: M
authors.lastname: Oscar-Berman
authors.forename: Thomas
authors.initials: T
authors.lastname: Simpatico
authors.forename: John
authors.initials: J
authors.lastname: Giordano
authors.forename: Scot
authors.initials: S
authors.lastname: Jones
authors.forename: Debmayla
authors.initials: D
authors.lastname: Barh
authors.forename: William B
authors.initials: WB
authors.lastname: Downs
authors.forename: Roger L
authors.initials: RL
authors.lastname: Waite
authors.forename: Margaret
authors.initials: M
authors.lastname: Madigan
authors.forename: Kristina
authors.initials: K
authors.lastname: Dushaj
authors.forename: Raquel
authors.initials: R
authors.lastname: Lohmann
authors.forename: Eric R
authors.initials: ER
authors.lastname: Braverman
authors.forename: David
authors.initials: D
authors.lastname: Han
authors.forename: Kenneth
authors.initials: K
authors.lastname: Blum
keywords: NAAT; Tourette's; aggressive sexual behavior; dopamine activation; repetitive paraphilia behavior; reward deficiency syndrome (RDS)