title: Gene "switch" stops colon cancer in mice.
abstract: Researchers developed a mouse model that enabled them to alternately silence and reactivate the tumor suppressor gene adenomatous polyposis coli, which is mutated in the majority of human colorectal cancers. When the tumor suppressor gene was reactivated, the tumors completely regressed within 2 weeks, even in the presence of mutations that commonly sustain disease progression.
mesh_terms: D000818:Animals; D018388:Codon, Terminator; D003110:Colonic Neoplasms / Q000235:genetics*; D017491:Genes, APC; D006801:Humans; D051379:Mice
chemical_list: D018388:Codon, Terminator