title: AIMing 2 Curtail Cancer.
abstract: The dysregulation of the relationship between gut microbiota and innate immune homeostasis can lead to a range of complex diseases. In this issue, Man et al. reveal that the intracellular innate sensor AIM2 regulates microbial and stem cell homeostasis in the gut to protect against colorectal cancer.
authors.affiliation: Institute for Systems Biology, Seattle, WA 98101, USA.
authors.forename: Leah M
authors.initials: LM
authors.lastname: Rommereim
authors.affiliation: Institute for Systems Biology, Seattle, WA 98101, USA. Electronic address: nsubrama@systemsbiology.org.
authors.forename: Naeha
authors.initials: N
authors.lastname: Subramanian
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D013234:Stem Cells / Q000473:pathology*
chemical_list: D004268:DNA-Binding Proteins