title: Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report.
abstract: Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33-year-old male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine.
authors.affiliation: Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Sung Gyu
authors.initials: SG
authors.lastname: Im
authors.affiliation: Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Sun Hong
authors.initials: SH
authors.lastname: Yoo
authors.affiliation: Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Park
authors.affiliation: Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Sun Kyung
authors.initials: SK
authors.lastname: Jang
authors.affiliation: Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Dong Ok
authors.initials: DO
authors.lastname: Jeon
authors.affiliation: Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of pulmonology-Allergy, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Mi Jung
authors.initials: MJ
authors.lastname: Oh
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D004342:Drug Hypersensitivity / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D000077213:Lamotrigine; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D017093:Liver Failure / Q000209:etiology*; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000188:drug therapy; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000077213:Lamotrigine
keywords: Hepatotoxicity; Hypersensitivity; Lamotrigine