title: Depressive symptoms and hormonal profile in climacteric women.
abstract: OBJECTIVE
  The aims of the study were: evaluation of depressive symptoms in climacteric women, comparison of depressive symptoms between peri- and post-menopausal women, and assessment of a possible relationship between the presence of depressive symptoms and the hormonal profile of the studied women.
  
  
  METHODS
  The study included 45 peri-menopausal and 95 post-menopausal women admitted to the Department of Gynecological Endocrinology, Poznafi University of Medical Sciences, because of climacteric symptoms. The following parameters were evaluated in all studied women: intensity of climacteric symptoms (Kupperman Index), intensity of depressive symptoms (Hamilton depression scale), serum concentrations of hypothalamic-pituitary-gonadal axis hormones (FSH, LH, 17β-estradiol), prolactin (PRL) and androgens [total testosterone, dehydroepiandrosterone sulfate (DHEAS)]. FSH, LH, 17β-estradiol, PRL, and total testosterone were evaluated by the immunoenzymatic methods and DHEAS was measured by the radioimmunological method.
  
  
  RESULTS
  Psychic and somatic manifestations of anxiety and fear, shallow sleep, and general somatic symptoms were the most frequent depressive symptoms in both studied groups. Both investigated groups differed in relation to the incidence and intensity of symptoms from the genital system (observed more often in post-menopausal women) and hypochondria (noted more frequently in peri-menopausal women). Numerous relationships between the incidence and intensity of certain symptoms and serum concentrations of the investigated hormones were found in both groups. The correlations were different in peri- and post-menopausal subjects.
authors.forename: R
authors.initials: R
authors.lastname: Słopień
authors.forename: A
authors.initials: A
authors.lastname: Słopień
authors.forename: A
authors.initials: A
authors.lastname: Warenik-Szymankiewicz
authors.forename: S
authors.initials: S
authors.lastname: Sajdak
mesh_terms: D001007:Anxiety / Q000523:psychology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D003863:Depression / Q000097:blood / Q000523:psychology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause / Q000097:blood / Q000502:physiology / Q000523:psychology*; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012890:Sleep; D012893:Sleep Wake Disorders / Q000523:psychology; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone