title: Hepatitis B Virus Infection Rate and Distribution in Chinese Systemic Lupus Erythematosus Patients.
abstract: BACKGROUND
  The aim of this study was to investigate the hepatitis B virus (HBV) infection rate in systemic lupus erythematosus (SLE) patients in China, and to determine the age and sex distribution.
  
  
  METHODS
  A total of 3981 SLE patients diagnosed in The First Affiliated Hospital of Sun Yat-sen University from January 1996 to December 2011 were retrospectively investigated for evaluation of the HBV infection rate. The HBV infection rate and the positive rate of hepatitis B surface antibody (HBsAb) and hepatitis B core antibody (HBcAb) were standardized to national census data in 2000 and compared with the prevalence found in the 2006 national survey.
  
  
  RESULTS
  The age and sex standardized HBV infection rate in Chinese SLE patients was 3.3%. The age and sex standardized positive rate of HBsAb and HBcAb were 58.1% and 26.1%, respectively. As compared with the prevalence from the 2006 national survey, the HBV infection rate and the positive rate of HBcAb were lower and the positive rate of HBsAb was higher in SLE patients aged 15-49 years old compared to peers in the general population. There was no difference in HBV infection rate between males and females (4.2% vs. 2.8%, p=0.088) in SLE patients.
  
  
  CONCLUSIONS
  The HBV infection rate was relatively lower in SLE patients compared with the general population, but there was no difference in pediatric patients or patients aged above 50 years old. Unlike in the general population, the HBV infection rate had no statistical differences between males and females in SLE patients.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).
authors.forename: Xumin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Epidemiology Research Unit and Clinical Trails Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).
authors.forename: Lingyao
authors.initials: L
authors.lastname: Hong
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).
authors.forename: Wang
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).
authors.forename: Meng
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).
authors.forename: Qiongqiong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).
authors.forename: Haiping
authors.initials: H
authors.lastname: Mao
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).
authors.forename: Xueqing
authors.initials: X
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies