title: Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies-A review.
abstract: Cells used in adoptive cell-transfer immunotherapies against cancer include dendritic cells (DCs), natural-killer cells, and CD8+T-cells. These cells may have limited efficacy due to their lifespan, activity, and immunosuppressive effects of tumor cells. Therefore, increasing longevity and activity of these cells may boost their efficacy. Four cytokines that can extend immune effector-cell longevity are IL-2, IL-7, IL-21, and IL-15. This review will discuss current knowledge on effector-cell lifespans and the mechanisms by which IL-2, IL-7, IL-15, and IL-21 can extend effector-cell longevity. We will also discuss how lifespan and efficacy of these cells can be regulated to allow optimal clinical benefits.
authors.affiliation: MRC Centre for Transplantation; Kings College London; Guys Hospital ; London, UK.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Nayar
authors.affiliation: MRC Centre for Transplantation; Kings College London; Guys Hospital ; London, UK.
authors.forename: Prokar
authors.initials: P
authors.lastname: Dasgupta
authors.affiliation: MRC Centre for Transplantation; Kings College London; Guys Hospital ; London, UK.
authors.forename: Christine
authors.initials: C
authors.lastname: Galustian
keywords: Adoptive transfer; Dendritic cells; NK cells; T cells; cytokines; lifespan