title: Concurrent thymoma, thymic carcinoma, and T lymphoblastic leukemia/lymphoma in an anterior mediastinal mass.
abstract: We report a case of a 62-year-old man with concurrent thymoma, thymic carcinoma, and T lymphoblastic leukemia/lymphoma. Computed tomography revealed a 5.5-cm anterior mediastinal mass, and surgical resection was performed. Histologically, the mass showed concurrent thymoma (type AB), thymic carcinoma, and T lymphoblastic leukemia/lymphoma. Lymphoma cells infiltrated in the left lung, pulmonary hilar lymph nodes, and involved bone marrow. The patient underwent chemotherapy for T lymphoblastic leukemia/lymphoma and achieved remission. One year after surgery, he remains free of both thymoma and thymic carcinoma, and T lymphoblastic leukemia/lymphoma remains complete remission under maintenance therapy. Thymoma and T lymphoblastic leukemia/lymphoma can combine in the same mass, although this is quite rare. At the time of the diagnosis of thymoma, additional attention should be directed toward lymphocytes in the background.
authors.affiliation: Division of Pathology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Ito
authors.affiliation: Division of Pathology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Division of Pathology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Akiko Miyagi
authors.initials: AM
authors.lastname: Maeshima
authors.affiliation: Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nakagawa
authors.affiliation: Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: Department of Hematology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Department of Hematology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Fukuhara
authors.affiliation: Division of Pathology, National Cancer Center Hospital, Tokyo 104-0045, Japan. Electronic address: tsutakoj@hirakata.kmu.ac.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuta
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008479:Mediastinal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013945:Thymoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: T lymphoblastic leukemia/lymphoma; Thymic carcinoma; Thymoma; Thymus