title: Increased IL-35 serum levels in systemic sclerosis and association with pulmonary interstitial involvement.
abstract: The objective of this study is to assess the serum IL-35 level and its association with clinical manifestations in patients with systemic sclerosis (SSc). IL-35 serum levels were measured by ELISA from 56 patients with SSc and 53 healthy controls. Association of IL-35 serum levels were sought with clinical parameters. Serum IL-35 levels were significantly higher in SSc patients (5.08 ± 0.76 pg/ml) than in healthy individuals (1.89 ± 0.69 pg/ml; p < 0.0001). Patients with lung fibrosis had higher IL-35 levels than those without fibrosis (7.75 ± 1.36 and 3.08 ± 0.70 pg/ml, respectively, p = 0.0022). IL-35 is elevated in the serum of patients with SSc and is associated with lung fibrosis. Our findings suggest that this cytokine can have a role in fibrotic diseases, but further studies are needed to address the role of IL-35 in the pathogenesis of SSc.
authors.affiliation: Laboratório de Imunomodulação e Novas Abordagens Terapêuticas, Recife, Brazil.
authors.forename: Andréa Tavares
authors.initials: AT
authors.lastname: Dantas
authors.forename: Sayonara Maria Calado
authors.initials: SM
authors.lastname: Gonçalves
authors.forename: Michelly Cristiny
authors.initials: MC
authors.lastname: Pereira
authors.forename: Rafaela Silva Guimarães
authors.initials: RS
authors.lastname: Gonçalves
authors.forename: Cláudia Diniz Lopes
authors.initials: CD
authors.lastname: Marques
authors.forename: Moacyr Jesus Barreto de Melo
authors.initials: MJ
authors.lastname: Rego
authors.forename: Ivan da Rocha
authors.initials: Ida R
authors.lastname: Pitta
authors.forename: Angela Luzia Branco Pinto
authors.initials: AL
authors.lastname: Duarte
authors.forename: Maira Galdino da Rocha
authors.initials: MG
authors.lastname: Pitta
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000097:blood*; D012595:Scleroderma, Systemic / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D007378:Interleukins; C532417:interleukin-35, human