title: The prevalence of IgG and IgA against adenoviruses in serum of children aged 11-26 months, hospitalised in the Clinical Paediatric Hospital in Warsaw, Poland.
abstract: Adenoviruses are widely spread viruses causing infections related mainly to children. Contact with the pathogen may result in the presence of either immunoglobulin (Ig) A or IgG antibodies in the serum. The aim of this study was to assess the prevalence of IgA and IgG antibodies against adenoviruses in serum of children aged 11-27 months, hospitalised at the Public Children's Clinical Hospital in Warsaw. Immunoassay tests DRG Adenovirus IgA ELISA and IgG DRG Adenovirus ELISA detecting antibodies against all pathogenic serotypes of adenoviruses were performed in 128 sera samples. A low percentage of positive results for both immunoglobulins, 17 cases (13.28%) for IgA and 16 cases (12.50%) for IgG antibodies respectively were reported. We conclude, that the prevalence of antibodies against adenoviruses does not coincide with epidemiological data on the spread of infections among young children. The assays performed may be more useful in distinguishing the active form of the infection from seropositivity due to prior infection.
authors.affiliation: Students Scientific Group at Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Poland.
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Trojnar
authors.affiliation: Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Poland.
authors.forename: Olga
authors.initials: O
authors.lastname: Ciepiela
authors.affiliation: Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Poland.
authors.forename: Urszula Anna
authors.initials: UA
authors.lastname: Demkow
keywords: ELISA; IgA; IgG; adenoviruses; antibodies