title: Cutaneous hyperneury: a new entity or an atypical cutaneous manifestation of MEN 2B?
abstract: A 33-year-old healthy woman with a family history of hyperlipidemia presented with asymptomatic skin-colored yellowish linear transverse plaques and papules on the trunk and forearms for a period of 6 months (Figure 1). She noticed that the lesions during this period have been gradually increasing in size and number. The initial clinical impression was eruptive xanthomas. A serum lipid profile showed a total serum cholesterol level of 406 mmol/L (high-density lipoprotein, 1.38 mmol/L; low-density lipoprotein, 2.73 mmol/L) and a triglyceride level of 1.1 mmol/L, which is within the normal range. A 4-mm punch biopsy was performed from the skin lesion on the patient's forearm, and findings showed the presence of bundles of mature nerve fibers in the papillary dermis (Figure 2) with a normal overlying epidermis. No abnormalities were seen in the subcutaneous tissue. There was no evidence of lipid deposition. A diagnosis of cutaneous hyperneury was made.
authors.forename: Taseer Ahmed
authors.initials: TA
authors.lastname: Bhatt
authors.forename: Samara
authors.initials: S
authors.lastname: Mimesh
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018814:Multiple Endocrine Neoplasia Type 2b / Q000150:complications*; D009463:Neuroma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000175:diagnosis* / Q000473:pathology