title: Early phase cancer clinical trials: design, ethics and future directions.
abstract: The main role of early phase clinical trials in cancer is to determine the dose to take forward for future clinical study. However, study design is changing in order to account for the change in focus of drug development toward molecularly targeted agents.
authors.affiliation: Clinical Research Fellow in Medical Oncology.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Coupe
authors.affiliation: Clinical Research Fellow in Medical Oncology in the Early Phase Trials Unit and the IGF Group, Department of Oncology, University of Oxford, Oxford.
authors.forename: Avinash
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Honorary Consultant in Medical Oncology and Senior Clinical Researcher in Experimental Cancer Therapeutics in the Early Phase Trials Unit, Department of Oncology, Churchill Hospital, University of Oxford, Oxford OX3 7LE.
authors.forename: Simon R
authors.initials: SR
authors.lastname: Lord
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic / Q000941:ethics* / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020714:Maximum Tolerated Dose; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents