title: Bulky mesonephric adenocarcinoma of the uterine cervix treated with neoadjuvant chemotherapy and radical surgery: report of the first case.
abstract: OBJECTIVE
  Malignant mesonephric adenocarcinoma of the uterine cervix is a rare occurrence with few cases described in the literature. Although surgery seems to be effective in the treatment of early-stage tumor, no cases describing outcomes of locally advanced stage are available.
  
  
  METHODS
  We report the first case of a patient with International Federation of Obstetrics and Gynecologists stage IIB mesonephric adenocarcinoma undergoing neoadjuvant chemotherapy and radical surgery.
  
  
  CONCLUSIONS
  Despite the inherent limitation of a single description of a case, our experience supports the utilization of neoadjuvant chemotherapy in patients with malignant mesonephric adenocarcinoma of the uterine cervix. Further prospective multi-institutional studies are needed.
authors.affiliation: Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Ditto
authors.affiliation: Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Martinelli
authors.affiliation: Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bogani
authors.affiliation: Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Gasparri
authors.affiliation: Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Violante Di
authors.initials: VD
authors.lastname: Donato
authors.affiliation: Department of Pathology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Biagio
authors.initials: B
authors.lastname: Paolini
authors.affiliation: Department of Pathology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Carcangiu
authors.affiliation: Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Domenica
authors.initials: D
authors.lastname: Lorusso
authors.affiliation: Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan - Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Raspagliesi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000628:therapy*; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008649:Mesonephroma / Q000175:diagnosis* / Q000628:therapy*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000628:therapy*