title: Synthetic tools for studying the chemical biology of InsP8.
abstract: To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.
authors.affiliation: Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Riley
authors.forename: Huanchen
authors.initials: H
authors.lastname: Wang
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Shears
authors.forename: Barry V
authors.initials: BV
authors.lastname: L Potter
mesh_terms: D001665:Binding Sites; D020134:Catalytic Domain; D011756:Diphosphates / Q000737:chemistry; D007295:Inositol Phosphates / Q000096:biosynthesis / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D017856:Phosphotransferases (Phosphate Group Acceptor) / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011756:Diphosphates; D007295:Inositol Phosphates; D017856:Phosphotransferases (Phosphate Group Acceptor)