title: Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients.
abstract: OBJECTIVE
  To compare the changes in anti-malondialdehyde-modified low-density lipoprotein (MDA-LDL) IgG levels among patients undergoing off-pump and on-pump coronary artery bypass grafting (CABG) or valvuloplasty.
  
  
  METHODS
  A total of 38, 39 and 34 patients who underwent off-pump CABG, on-pump CABG and valvuloplasty, respectively, were enrolled in this study. Serum anti-MDA-LDL IgG values were measured 24 h before and after the operative procedures and at discharge. Echocardiography was also done before surgery and before discharge. The results were compared with values from 50 healthy controls.
  
  
  RESULTS
  In all patients, a reduction in antibody titers was observed post-operatively. However, the decrease was significant only in the off-pump CABG - before surgery: 42.33 (25.83-58.51), after surgery: 30.86 (16.36-51.33) and at discharge: 10.96 (6.82-23.57; p = 0.027). There was a significant positive association between anti-MDA-LDL IgG levels and ejection fraction (r = 0.248, p = 0.036) and a negative association with E/E', a marker of pulmonary capillary wedge pressure, in the coronary patients (r = -0.345, p = 0.012), but no significant associations were found in patients with valvular heart disease.
  
  
  CONCLUSIONS
  Serum anti-MDA-LDL IgG levels were associated with cardiac function indices in coronary patients undergoing CABG.
authors.affiliation: Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amir Ali
authors.initials: AA
authors.lastname: Rahsepar
authors.forename: Asadollah
authors.initials: A
authors.lastname: Mirzaee
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Moodi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Khorashadizadeh
authors.forename: Behrooz
authors.initials: B
authors.lastname: Mottahedi
authors.forename: Jamil
authors.initials: J
authors.lastname: Esfehanizadeh
authors.forename: Ali
authors.initials: A
authors.lastname: Azari
authors.forename: Roshanak
authors.initials: R
authors.lastname: Khojasteh
authors.forename: Somayeh
authors.initials: S
authors.lastname: Mousavi
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Paydar
authors.forename: Maral
authors.initials: M
authors.lastname: Amini
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers; D002302:Cardiac Output; D006348:Cardiac Surgical Procedures / Q000379:methods*; D058385:Cardiac Valve Annuloplasty / Q000379:methods; D001026:Coronary Artery Bypass / Q000379:methods; D003324:Coronary Artery Disease / Q000601:surgery*; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008315:Malondialdehyde / Q000031:analogs & derivatives* / Q000276:immunology; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; C569869:malondialdehyde-low density lipoprotein, human; D008315:Malondialdehyde