title: Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum.
abstract: OBJECTIVE
  To determine serum thiol-disulfide homeostasis in hyperemesis gravidarum.
  
  
  METHODS
  Twenty-six pregnant women with hyperemesis gravidarum and 37 healthy pregnant women were included in the study. Native thiol, disulfide and total thiol concentrations were measured with a novel automated method.
  
  
  RESULTS
  Serum disulfide levels were 15.68±4.41 μmol l(-1) in the hyperemesis gravidarum group and 13.49±2.81 μmol l(-1) in the healthy group (P=0.031). Native thiol levels were 213.86±26.29 μmol l(-1) in the hyperemesis gravidarum group and 232.18±19.21 μmol l(-1) in healthy group (P=0.004), and total thiol levels were 245.23±28.58 μmol l(-1) in the hyperemesis gravidarum group and 259.17±19.94 μmol l(-1) in the healthy group (P=0.038).
  
  
  CONCLUSIONS
  Native and total thiol were deficient in the hyperemesis gravidarum group and this deficiency was correlated with the severity of the disease. The thiol-disulfide balance has shifted to the oxidative side. This metabolic disturbance may have a role in the pathogenesis of hyperemesis gravidarum.
authors.affiliation: Department of Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ergin
authors.affiliation: Department of Obstetrics and Gynecology, Dr Nafiz Körez Sincan State Hospital, Ankara, Turkey.
authors.forename: B D
authors.initials: BD
authors.lastname: Cendek
authors.affiliation: Department of Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Neselioglu
authors.affiliation: Department of Obstetrics and Gynecology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: A F
authors.initials: AF
authors.lastname: Avsar
authors.affiliation: Department of Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Erel
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004220:Disulfides / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood*; D011247:Pregnancy; D013438:Sulfhydryl Compounds / Q000097:blood*; D055815:Young Adult
chemical_list: D004220:Disulfides; D013438:Sulfhydryl Compounds