title: Clonal Spread of Enterotoxigenic Escherichia coli O128:H45 Strain in the Neonate Unit.
abstract: Enterotoxigenic Escherichia coli (ETEC) has the potential to cause nosocomial infantile diarrhea in a hospital setting. We detected 12 ETEC serotype O128:H45 isolates from diarrheal neonates in our neonatal unit from July through October 2012. These infants developed hospital-acquired and epidemiologically related diarrhea. Pulsed-field gel electrophoresis analysis and multilocus sequence typing of these 12 isolates suggested that a specific clone of ETEC serotype O128:H45-CS21-ST2332 caused nosocomial diarrhea among neonates. Of concern, this ETEC clone strain was resistant to multiple drugs, particularly third-generation cephalosporins.
authors.affiliation: Department of Infectious Diseases, Children's Hospital of Fudan University.
authors.forename: Mei
authors.initials: M
authors.lastname: Zeng
authors.forename: Wenjing
authors.initials: W
authors.lastname: Shi
authors.forename: Hailing
authors.initials: H
authors.lastname: Chang
authors.forename: Aimin
authors.initials: A
authors.lastname: Wang
authors.forename: Leiyan
authors.initials: L
authors.lastname: He
authors.forename: Pan
authors.initials: P
authors.lastname: Fu
authors.forename: Xuebin
authors.initials: X
authors.lastname: Xu
authors.forename: Chuanqing
authors.initials: C
authors.lastname: Wang
mesh_terms: D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D054307:Enterotoxigenic Escherichia coli / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D008297:Male; D058889:Molecular Typing; D012189:Retrospective Studies; D065288:Serogroup