title: Chemical composition and antibacterial activity of essential oil of Nepeta graciliflora Benth. (Lamiaceae).
abstract: The chemical composition of the essential oil obtained from aerial parts of Nepeta graciliflora was analysed, for the first time, by GC-FID and GC-MS. A total of 27 compounds were identified, constituting over 91.44% of oil composition. The oil was strongly characterised by sesquiterpenes (86.72%), with β-sesquiphellandrene (28.75%), caryophyllene oxide (12.15%), α-bisabolol (8.97%), α-bergamotene (8.51%), β-bisabolene (6.33%) and β-Caryophyllene (5.34%) as the main constituents. The in vitro activity of the essential oil was determined against four micro-organisms in comparison with chloramphenicol by the agar well diffusion and broth dilution method. The oil exhibited good activity against all tested organisms.
authors.affiliation: a Department of Chemistry , Kumaun University , SSJ Campus, Almora , Uttarakhand 263601 , India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Sharma
authors.affiliation: a Department of Chemistry , Kumaun University , SSJ Campus, Almora , Uttarakhand 263601 , India.
authors.forename: G C
authors.initials: GC
authors.lastname: Shah
authors.affiliation: b Department of Chemistry , MM University , Sadopur, Ambala , Harayana , India.
authors.forename: Rabia
authors.initials: R
authors.lastname: Sharma
authors.affiliation: c G.B. Pant Institute of Himalayan Environment & Development , Katarmal, Almora , India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Dhyani
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D000081222:Monocyclic Sesquiterpenes; D027521:Nepeta / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001643:Bridged Bicyclo Compounds; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C423904:alpha-bergamotene; C004497:bisabolol; C024714:caryophyllene; C531191:beta-bisabolene; C515179:caryophyllene oxide
keywords: Nepeta graciliflora; antibacterial activity; chemical composition; essential oil