title: Distribution and antimicrobial susceptibility of bacteria from adults with community-acquired pneumonia or complicated skin and soft tissue infections in France: the nationwide French PREMIUM study.
abstract: The empirical therapy of community-acquired pneumonia (CAP) and complicated skin and soft tissue infections (cSSTIs) must be based on updated bacterial distribution and susceptibility data. A nationwide study consecutively collected 1288 isolates from CAP (n=467) and cSSTIs (n=821) from 18 French hospitals between 2012 and 2013. The MIC values of commonly used antimicrobial agents, including ceftaroline, were determined. Bacterial distribution featured Pneumococcus, Haemophilus influenzae, and Staphylococcus aureus for CAPs and S. aureus, β-hemolytic streptococci and Enterobacteriaceae for cSSTIs. Antimicrobial susceptibility testing indicated i) the sustained third-generation cephalosporins and levofloxacin activity against pneumococci and H. influenzae, ii) no methicillin-resistant Staphylococcus aureus emergence among respiratory pathogens, iii) the high in vitro activity of ceftaroline against staphylococci from cSSTIs (98.7% susceptibility), and iv) the worrisome decreasing fluoroquinolone and third-generation cephalosporin susceptibilities among Enterobacteriaceae. This laboratory-based survey depicts a contrasting situation and supports the scoring of patients for the resistant pathogen risk before empirical therapy.
authors.affiliation: Department of Microbiology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France.
authors.forename: C
authors.initials: C
authors.lastname: Leprince
authors.affiliation: Department of Microbiology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France; University Paris East Créteil, 94000 Créteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Desroches
authors.affiliation: Department of Microbiology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France; Department of Biology, Sud-Essonne Hospital, 91150 Etampes, France.
authors.forename: A
authors.initials: A
authors.lastname: Emirian
authors.affiliation: Department of Microbiology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France.
authors.forename: C
authors.initials: C
authors.lastname: Coutureau
authors.affiliation: Department of Microbiology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France.
authors.forename: L
authors.initials: L
authors.lastname: Anais
authors.affiliation: Department of Microbiology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France.
authors.forename: V
authors.initials: V
authors.lastname: Fihman
authors.affiliation: Department of Microbiology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France; University Paris East Créteil, 94000 Créteil, France.
authors.forename: C J
authors.initials: CJ
authors.lastname: Soussy
authors.affiliation: Department of Microbiology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France; University Paris East Créteil, 94000 Créteil, France. Electronic address: jean-winoc.decousser@hmn.aphp.fr.
authors.forename: J W
authors.initials: JW
authors.lastname: Decousser
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000382:microbiology*; D017192:Skin Diseases, Bacterial / Q000453:epidemiology / Q000382:microbiology*; D018461:Soft Tissue Infections / Q000453:epidemiology / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Ceftaroline; Cutaneous infection; Lower respiratory tract infection; Methicillin-resistant Staphylococcus aureus