title: B cells drive Th2 responses by instructing human dendritic cell maturation.
abstract: Dendritic cells (DCs) are known to regulate the functions of various immune cells. Reciprocal signaling by these immune cells also "educate" the DCs and determine the quality of the ensuing immune responses. Recently, we demonstrated that human DCs undergo maturation upon interaction with activated B cells to acquire unique abilities to promote polarization of Th2 cells.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale ; Paris, France ; Centre de Recherche des Cordeliers; Equipe - Immunopathology and Therapeutic Immunointervention ; Paris, France ; Sorbonne Universités, UPMC Univ Paris , Paris, France ; Emory Vaccine Center; Yerkes National Primate Research Center; Emory University ; Atlanta, GA, USA.
authors.forename: Mohan S
authors.initials: MS
authors.lastname: Maddur
authors.affiliation: Institut National de la Santé et de la Recherche Médicale ; Paris, France ; Centre de Recherche des Cordeliers; Equipe - Immunopathology and Therapeutic Immunointervention ; Paris, France ; Sorbonne Universités, UPMC Univ Paris , Paris, France ; Université Paris Descartes ; Sorbonne Paris Cité ; Paris, France ; International Associated Laboratory IMPACT (Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India); National Institute of Immunohematology ; Mumbai, India.
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
keywords: B lymphocytes; BAFF-R, B–cell-activating factor receptor; BCR, B-cell receptor; DAMPs, damage-associated molecular patterns; DCs, dendritic cells; OX-40 ligand; OX-40L, OX-40 ligand; PAMPs, pathogen-derived molecular patterns (PAMPs); TACI, transmembrane activator and calcium-modulating cyclophilin ligand interactor; Th2; Tregs, regulatory T cells; antibody response; antitumor; dendritic cells