title: Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma.
authors.affiliation: Department of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA.
authors.forename: Anupam
authors.initials: A
authors.lastname: Mitra
authors.affiliation: Department of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA.
authors.forename: Jesus I
authors.initials: JI
authors.lastname: Luna
authors.affiliation: Department of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA.
authors.forename: Alina I
authors.initials: AI
authors.lastname: Marusina
authors.affiliation: Department of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Merleev
authors.affiliation: School of Medicine, University of California Davis, VA Medical Center Sacramento, Mather, California, USA.
authors.forename: Smriti
authors.initials: S
authors.lastname: Kundu-Raychaudhuri
authors.affiliation: Department of Dermatology, Stanford University, Redwood City, California, USA.
authors.forename: David
authors.initials: D
authors.lastname: Fiorentino
authors.affiliation: School of Medicine, University of California Davis, VA Medical Center Sacramento, Mather, California, USA.
authors.forename: Siba P
authors.initials: SP
authors.lastname: Raychaudhuri
authors.affiliation: Department of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA. Electronic address: emaverakis@yahoo.com.
authors.forename: Emanual
authors.initials: E
authors.lastname: Maverakis
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001707:Biopsy, Needle; D002478:Cells, Cultured; D005347:Fibroblasts; D005355:Fibrosis / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D007150:Immunohistochemistry; D058990:Molecular Targeted Therapy; D010766:Phosphorylation / Q000187:drug effects; D016133:Polymerase Chain Reaction / Q000379:methods; D045743:Scleroderma, Diffuse / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D012680:Sensitivity and Specificity; D020123:Sirolimus / Q000494:pharmacology*; D051899:Smad2 Protein / Q000187:drug effects / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000187:drug effects / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000187:drug effects / Q000378:metabolism*; D014227:Triazines / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D007093:Imidazoles; C568605:OSI 027; D051899:Smad2 Protein; D016212:Transforming Growth Factor beta; D014227:Triazines; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus