title: A Hypereosinophilic Syndrome with Cardiac Involvement from Thrombotic Stage to Fibrotic Stage.
abstract: Cardiac involvement is a major cause of morbidity and mortality in hypereosinophilic syndrome (HES). It is classified into 3 stages by the degree of eosinophils-mediated heart injury; acute necrotic stage, thrombotic stage, and fibrotic stage. Nonetheless, definitive evidence that each patient passes sequentially through these stages is lacking. We present a case of 48-year-old male patient with dyspnea and peripheral edema who underwent valve replacement surgery due to severe mitral regurgitation. After the valve replacement, HES with cardiac involvement in the thrombotic stage was diagnosed. In the follow-up study, the patient progressed into fibrotic stage of HES.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Nam Kyun
authors.initials: NK
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Chang-Yeon
authors.initials: CY
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Se Yong
authors.initials: SY
authors.lastname: Jang
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Myung Hwan
authors.initials: MH
authors.lastname: Bae
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Jang Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Dong Heon
authors.initials: DH
authors.lastname: Yang
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Hun Sik
authors.initials: HS
authors.lastname: Park
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Yongkeun
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Shung Chull
authors.initials: SC
authors.lastname: Chae
keywords: Fibrotic stage; Hypereosinophilic syndrome; Mitral regurgitation; Thrombotic stage