title: Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats.
abstract: Jia-Yuan-Qing pill (JYQP) composed ofPorcellio laevisLatreille, Corydalis Rhizoma and Radix Cynanchi Paniculati at a ratio of 9:7:7 has been found to be an effective analgesic agent. The present study aimed to evaluate the safety, addictive potential and anti-cancer pain activity of JYQP in a rat model. During the 6-month chronic toxicity test, no significant changes in general behavior, defecation, postural abnormalities, dietary or water intake or blood biochemical parameters were observed in male and female rats. Although a high dose of JYQP (5 g/kg) caused swelling of the liver, spleen and kidney in male and female rats, no pathological changes were observed in all organs examined via hematoxylin and eosin staining. The analgesic effect of JYQP on bone cancer pain was successfully confirmed in a rat model of Walker 256 cell-induced bone cancer. In contrast to morphine, in a physical dependence test, JYQP produced no withdrawal symptoms following chronic administration. The data from this study provide experimental evidence supporting the clinical use of JYQP as an effective, safe and non-addictive agent for the treatment of bone cancer pain.
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Y E
authors.initials: YE
authors.lastname: Tian
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Teng
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Zhen-Zuo
authors.initials: ZZ
authors.lastname: Wang
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Qing-Fan
authors.initials: QF
authors.lastname: Meng
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Lu
authors.affiliation: Jilin Academy of Traditional Chinese Medicine, Changchun, Jilin 130012, P.R. China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Tian
authors.affiliation: Jilin Academy of Traditional Chinese Medicine, Changchun, Jilin 130012, P.R. China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Zheng
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: D I
authors.initials: DI
authors.lastname: Wang
authors.affiliation: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: LE-Sheng
authors.initials: LS
authors.lastname: Teng
keywords: Jia-Yuan-Qing pill; bone cancer pain; long-term toxicity; psychological addiction; traditional Chinese medicine