title: Remitting seronegative symmetrical synovitis with pitting edema associated with parvovirus B19 infection: two new cases and review of the comorbidities.
abstract: BACKGROUND
  Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare syndrome consisting of acute symmetrical tenosynovitis of the hands and wrists associated with pain and marked pitting edema of the dorsum of the hands or the feet. Persistent rheumatoid factor seronegativity and elevated acute phase reactants are the rule, while radiographic findings are characterized by the absence of bony erosions. The syndrome has occasionally been associated with a wide range of diseases including solid and hematological malignancies, polymyalgia rheumatica, and other inflammatory rheumatic diseases.
  
  
  METHODS
  Two patients with skin eruption on hands and feet associated with arthromyalgias have been investigated to confirm diagnosis of RS3PE and to detect comorbidities. A revision of all the possible medical conditions correlated to RS3PE has been performed.
  
  
  RESULTS
  We report two cases of RS3PE associated with Parvovirus B19 infection/reactivation. There are very few reports on the association between RS3PE and infectious agents, and in only one case the syndrome has been correlated to parvovirus infection.
  
  
  CONCLUSIONS
  We want to underline the importance for patients with RS3PE to be seen by dermatologists who should become familiar with this syndrome and remark that Parvovirus B19 infection may be a potential cause of RS3PE.
authors.affiliation: DISSAL, Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Drago
authors.affiliation: DISSAL, Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ciccarese
authors.affiliation: DISSAL, Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
authors.forename: Arianna F
authors.initials: AF
authors.lastname: Agnoletti
authors.affiliation: DISSAL, Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
authors.forename: Ludovica
authors.initials: L
authors.lastname: Cogorno
authors.affiliation: UO Radiologia 1, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Muda
authors.affiliation: DISSAL, Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cozzani
authors.affiliation: DISSAL, Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
authors.forename: Aurora
authors.initials: A
authors.lastname: Parodi
mesh_terms: D000328:Adult; D000842:Ankle; D002097:C-Reactive Protein / Q000378:metabolism; D015897:Comorbidity; D004487:Edema / Q000175:diagnosis*; D005534:Foot Diseases / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000175:diagnosis*; D016732:Parvovirus B19, Human; D012217:Rheumatoid Factor / Q000097:blood; D013577:Syndrome; D013717:Tenosynovitis / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D014953:Wrist
chemical_list: D002097:C-Reactive Protein; D012217:Rheumatoid Factor