title: Low titer of antibody against Toxoplasma gondii may be related to resistant to cancer.
abstract: BACKGROUND
  Toxoplasma gondii is a protozoan parasite with a world-wide distribution. However, the majority of infected cases remain symptomless. There are raising scientific evidences indicating that parasitic infections induce antitumor activity against certain types of cancers. The inhibitory effect of T. gondii on cancer growth has also been shown in cell culture and mouse model.
  
  
  OBJECTIVE
  Considering the anti-tumor effect of this parasite, in this study the relationship between low titer of antibodies against T. gondii and resistant to cancers has been investigated.
  
  
  METHODS
  In two separate experiments, anti T. gondii antibody was estimated in 150 patients with cancer and 120 normal people.
  
  
  METHODS
  Chi-square test was used for data analysis.
  
  
  RESULTS
  The frequency of low titer antibody against Toxoplasma gondii in cancer patients was significantly higher than the frequency of low-titer antibody against this parasite in normal people.
  
  
  CONCLUSIONS
  Exposure to T. gondii may be related to resistance to cancer.
authors.forename: Maryam Sharafi
authors.initials: MS
authors.lastname: Seyedeh
authors.forename: Salehi
authors.initials: S
authors.lastname: Nahid
authors.forename: Mortazavi
authors.initials: M
authors.lastname: Nahid
authors.forename: Danesh Pour
authors.initials: DP
authors.lastname: Shima
authors.forename: Yousefi
authors.initials: Y
authors.lastname: Morteza
authors.affiliation: Cancer Prevention Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Yousofi Darani
authors.initials: YD
authors.lastname: Hossein
mesh_terms: D000328:Adult; D000368:Aged; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000276:immunology* / Q000473:pathology*; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000150:complications / Q000276:immunology*; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan