title: Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study.
abstract: BACKGROUND
  Despite the extensive reporting of pediatric ulcerative colitis (UC) from industrialized developed countries, reports from developing countries are limited to small-case series from single centers. The objective of our large multicenter study was to determine the clinical, laboratory, endoscopic characteristics of UC in children from a developing country, Saudi Arabia.
  
  
  METHODS
  A retrospective study of children diagnosed with UC under the age of 18 years during the period from 2003 to 2012.
  
  
  METHODS
  Patients enrolled from 15 medical centers from different regions in Saudi Arabia. A unified database collection form specifically designed for this study was completed by all participating centers.
  
  
  RESULTS
  A total of 188 children were diagnosed with UC during the study period (97 males [51.6%] and 91 females [48.4%]). The mean age at diagnosis was 9.1 years, and the mean duration of symptoms before diagnosis was 8.7 months. Consanguinity was present in 57 cases (32.6%), and the family history of inflammatory bowel disease (IBD) was noted in 16 cases (9%). The most common clinical presentation was blood in stool (90%), followed by diarrhea (86%) and abdominal pain (62%). Laboratory investigations revealed elevated erythrocyte sedimentation rate (82%), anemia (75%), thrombocytosis (72%), and hypoalbuminemia (33%). The extent of the disease was pan colonic in 46.1%, and confined to left side of colon and rectum in 23% and 9.6% of the cases, respectively.
  
  
  CONCLUSIONS
  This demographically pediatric IBD retrospective study revealed age-related variation in the distribution of IBD. Clinical presentation, with a high prevalence of positive consanguinity and positive family history, was noted in young patients with UC. The data from this study indicate that UC is increasingly recognized in Saudi Arabia and show many similarities to data from North America and Europe.
authors.affiliation: Dr. Khalid AlSaleem, MBC 58 Department of Pediatrics,, King Faisal Specialist Hospital and Research Centre,, PO Box 3354, Riyadh 11211,, Saudi Arabia, T: 966505445487, ksaleem@kfshrc.edu.sa.
authors.forename: Khalid
authors.initials: K
authors.lastname: AlSaleem
authors.forename: Mohammad Issa
authors.initials: MI
authors.lastname: El Mouzan
authors.forename: Omar I
authors.initials: OI
authors.lastname: Saadah
authors.affiliation: Dr. Khalid AlSaleem, MBC 58 Department of Pediatrics,, King Faisal Specialist Hospital and Research Centre,, PO Box 3354, Riyadh 11211,, Saudi Arabia, T: 966505445487, ksaleem@kfshrc.edu.sa.
authors.forename: Bader
authors.initials: B
authors.lastname: AlSaleem
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Al-Hussaini
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hassosa
authors.forename: Al-Mehaidib
authors.initials: AM
authors.lastname: Ali
authors.forename: Mohammed Othman
authors.initials: MO
authors.lastname: Banemai
authors.forename: Hana
authors.initials: H
authors.lastname: Halaby
authors.forename: Mohammed
authors.initials: M
authors.lastname: El Edreesi
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001799:Blood Sedimentation; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology*; D003106:Colon / Q000473:pathology; D003241:Consanguinity; D016208:Databases, Factual; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D012007:Rectum / Q000473:pathology; D012189:Retrospective Studies; D012529:Saudi Arabia / Q000453:epidemiology; D017678:Sex Distribution