title: Low levels of mannose-binding lectin at admission increase the risk of adverse neurological outcome in preterm infants: a 1-year follow-up study.
abstract: OBJECTIVE
  The aim of this study was to explore the association between serum levels of mannose-binding lectin (MBL) at admission and neurodevelopmental outcomes in a group of Chinese preterm infants, observed prospectively, until 1-year of corrected age (CA).
  
  
  METHODS
  All preterm infants used in this study were received from the neonatal intensive care unit (NICU) of our Hospital between 1 January 2012 and 31 August 2013. Serum levels of MBL and clinical data were obtained at the time of admission. The influence of MBL levels on neurological outcome was assessed by logistic regression analysis. Clinical follow-up was performed at 1 year.
  
  
  RESULTS
  The study cohort consisted of 175 neonates at baseline and 105 finished the 1-year follow-up. The mean serum MBL levels at the time of admission were significantly lower in children with adverse neurological outcomes as compared with children with no adverse [0.53 (SD = 0.09) μg/ml versus 0.80 (SD = 0.17) μg/ml, respectively; t = 8.342, p < 0.0001]. In multivariate analysis, there was an increased risk of adverse neurological outcomes associated with MBL ≤ 0.68 μg/ml [odds ratios (OR) = 12.11, 95% confidence interval (CI): 2.31-30.32; p < 0.0001] after adjusting for possible factors.
  
  
  CONCLUSIONS
  Preterm infants who had low levels of MBL at admission are exposed to an increased risk of adverse neurological outcomes.
authors.affiliation: a Department of Neonatology , The Second Affiliated Hospital of Shandong University , Jinan , People's Republic of China .
authors.forename: Jiang
authors.initials: J
authors.lastname: Xue
authors.affiliation: a Department of Neonatology , The Second Affiliated Hospital of Shandong University , Jinan , People's Republic of China .
authors.forename: Ai-hong
authors.initials: AH
authors.lastname: Liu
authors.affiliation: b Department of Padiatric Surgery , Central Hospital of Taian City , Taian , People's Republic of China , and.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.affiliation: c Department of Pediatric Intensive Care , Jinan Central Hospital affiliated Shandong University , Jinan , People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Si
authors.affiliation: a Department of Neonatology , The Second Affiliated Hospital of Shandong University , Jinan , People's Republic of China .
authors.forename: Ya-qiong
authors.initials: YQ
authors.lastname: Li
mesh_terms: D002657:Child Development; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D037601:Mannose-Binding Lectin / Q000097:blood*; D065886:Neurodevelopmental Disorders / Q000097:blood*; D011446:Prospective Studies
chemical_list: D037601:Mannose-Binding Lectin
keywords: Mannose-binding lectin; neurodevelopmental outcomes; predictor; preterm infants