title: PHOTOLABILE A1-ADENOSINE RECEPTOR AGONISTS AS "CAGED" ELECTROPHYSIOLOGICAL PROBES.
abstract: 5'-Ether derivatives of the potent adenosine agonist N6-cyclopentyladenosine (CPA) were designed as "caged" ligands for the activation of A1-adenosine receptors followingin situphotolysis. The synthesis involved a 2',3'-diol protection scheme using the acid labile ethoxymethynyl group. Generation of CPA was demonstrated chromatographically and in a bioassay measuring the inhibition of synaptic potentials in the rat hippocampus.
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
authors.forename: Michel C
authors.initials: MC
authors.lastname: Maillard
authors.affiliation: Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908.
authors.forename: Lauren
authors.initials: L
authors.lastname: Arlinghaus
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
authors.forename: Marc
authors.initials: M
authors.lastname: Glashofer
authors.affiliation: Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908.
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Jacobson