title: Short-Term Treprostinil Use in Infants with Congenital Diaphragmatic Hernia following Repair.
abstract: We describe 2 infants with congenital diaphragmatic hernia with severe pulmonary hypertension at 6 weeks. Treprostinil was used with rapid clinical improvement. Repeat cardiac catheterization showed dramatic improvement. Both infants were weaned off the drug, representing the first reports of successful short-term treprostinil use in neonates with congenital diaphragmatic hernia.
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA.
authors.forename: Emma
authors.initials: E
authors.lastname: Olson
authors.affiliation: Division of Neonatology, Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Lusk
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Fineman
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA.
authors.forename: Laura
authors.initials: L
authors.lastname: Robertson
authors.affiliation: Division of Neonatology, Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA. Electronic address: kellerr@peds.ucsf.edu.
authors.forename: Roberta L
authors.initials: RL
authors.lastname: Keller
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D065630:Hernias, Diaphragmatic, Congenital / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn
chemical_list: D000959:Antihypertensive Agents; D011464:Epoprostenol; C427248:treprostinil