title: Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders.
abstract: Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Caitlin N
authors.initials: CN
authors.lastname: Spaulding
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Karen W
authors.initials: KW
authors.lastname: Dodson
authors.affiliation: Department of MCDB, University of Michigan, Ann Arbor, MI 48109-1048, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Chapman
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: hultgren@wusm.wustl.edu.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Hultgren
mesh_terms: D000682:Amyloid / Q000378:metabolism*; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D004269:DNA, Bacterial / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D012480:Salmonella Infections / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*
chemical_list: D000682:Amyloid; D001426:Bacterial Proteins; D004269:DNA, Bacterial