title: Celiac disease as an autoimmune condition.
abstract: Autoimmune diseases have become a major medical problem of recent years. Celiac disease is an autoimmune disease model. The aim of our study was to follow the changes in the clinical autoimmunity picture of the celiac disease from recent years. The study of autoimmunity in celiac disease has focused on associated diseases with the aforementioned disease: type 1 diabetes mellitus, thyroid autoimmunity disease, Graves' disease, Hashimoto's disease, systemic lupus erythematosus, systemic sclerosis, spondyloarthritis, hyperprolactinemia, Turner syndrome, Addison's disease, sensory neuronopathies. Immune reactivity to tissue transglutaminase targeted autoantibodies and other autoantigens, including transglutaminase 3, actin, ganglioside, collagen, calreticulin or zonulin which have been reported in the celiac disease. New research directions given by celiac disease autoimmunity, interleukin 1, interleukin 2, protein tyrosine phosphatase non-receptor type 22, CD4+CD25+ T lymphocytes, cytotoxic T-lymphocyte antigen 4, infection with Necator americanus and definitive identification of pathogenic T cell epitopes, seem to provide a solution in celiac disease treatment.
authors.affiliation: Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania ; Children's Emergency Hospital, Cluj-Napoca, Romania.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Samasca
authors.affiliation: Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania ; Children's Emergency Hospital, Cluj-Napoca, Romania.
authors.forename: Genel
authors.initials: G
authors.lastname: Sur
authors.affiliation: Molecular Biology Center, Institute for Interdisciplinary Research on Bio-Nano-Sciences, "Babes-Bolyai" University, Cluj-Napoca, Romania.
authors.forename: Iulia
authors.initials: I
authors.lastname: Lupan
authors.affiliation: Department of Cellular and Molecular Biology, University of Medicine and Pharmacy Targu Mures, Romania.
authors.forename: Mariana
authors.initials: M
authors.lastname: Tilinca
authors.affiliation: Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Diana
authors.initials: D
authors.lastname: Deleanu
keywords: autoimmunity disease; diagnosis; research direction