title: Spiroalkaloids from Shensong Yangxin capsule.
abstract: Four spiroalkaloids, including a new compound shensongine A (1), were isolated from the anti-arrhythmic TCM formula Shensong Yangxin capsule. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 3 displayed cardiovascular activities by shortened APD in rat myocardial cells. These compounds were possibly generated from precursors in different composed herbal medicines during the processing of the TCM formula.
authors.affiliation: a Guangdong Institute for Food and Drug Control , Guangzhou 510180 , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ding
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Hou
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D032383:Myocytes, Cardiac / Q000187:drug effects; D051381:Rats; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal; D013141:Spiro Compounds; C000601776:shensongine A
keywords: Shensong Yangxin capsule; TCM formula; spiroalkaloids