title: Neonatal Cholestasis Caused by Undiagnosed Maternal Graves' Disease.
abstract: Neonatal cholestasis results from a variety of etiologies, including anatomic, infectious, and metabolic abnormalities. Hyperthyroidism, in contrast to hypothyroidism, is infrequently associated with neonatal cholestasis. Newborn screening is an important tool to detect newborn metabolic disorders, including thyroid dysfunction. However, one must exercise caution when interpreting these reports; typically only high thyroid stimulating hormone (TSH) levels are flagged as abnormal, while low or undetectable levels may not be. We present a unique case of cholestasis in a hyperthyroid neonate of an untreated, undiagnosed mother with Graves' disease; the infant's metabolic screen was not flagged as abnormal.
authors.affiliation: University of Utah School of Medicine, Salt Lake City, UT ; Northwest Pediatric Gastroenterology, LLC, Portland, OR.
authors.forename: Raghu U
authors.initials: RU
authors.lastname: Varier
authors.affiliation: University of Utah School of Medicine, Salt Lake City, UT.
authors.forename: M Kyle
authors.initials: MK
authors.lastname: Jensen
authors.affiliation: University of Utah School of Medicine, Salt Lake City, UT.
authors.forename: Christa J
authors.initials: CJ
authors.lastname: Adams
authors.affiliation: University of Utah School of Medicine, Salt Lake City, UT.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Book