title: Expedient and Divergent Tandem One-Pot Synthesis of Benz[e]indole and Spiro[indene-1,3'-pyrrole] Derivatives from Alkyne-Tethered Chalcones/Cinnamates and TosMIC.
abstract: An efficient solvent-dependent regioselective [3 + 2]-cycloaddition/iodocyclization cascade reaction of alkyne-tethered chalcones/cinnamates and TosMIC has been developed. The reaction represents a novel protocol for the expedient and divergent one-pot synthesis of benz[e]indoles and spiro[indene-1,3'-pyrroles] from acyclic common precursors at room temperature.
authors.affiliation: †Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.affiliation: †Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Chengjie
authors.initials: C
authors.lastname: Feng
authors.affiliation: ‡Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: †Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Li
authors.affiliation: †Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Pan
authors.affiliation: †Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Xianxiu
authors.initials: X
authors.lastname: Xu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D047188:Chalcones / Q000737:chemistry*; D002934:Cinnamates / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D061565:Cycloaddition Reaction; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D047188:Chalcones; D002934:Cinnamates; D003486:Cyanides; D007211:Indoles; D011758:Pyrroles; D013141:Spiro Compounds; C000602345:spiro(indene-1,3'-pyrrole); C469613:tosylmethyl isocyanide