title: Tedizolid Adsorption and Transmembrane Clearance during in vitro Continuous Renal Replacement Therapy.
abstract: OBJECTIVE
  To study transmembrane clearance (CLTM) and adsorption of tedizolid, a novel oxazolidinone antibiotic, in continuous hemofiltration (CVVH) and continuous hemodialysis (CVVHD).
  
  
  METHODS
  In vitro CVVH/CVVHD models with polysulfone and AN69 hemodiafilters were used. Tedizolid CLTM during CVVH/CVVHD was assessed at various ultrafiltrate (Quf) and dialysate rates (Qd). Tedizolid adsorption was tested in a recirculating CVVH model over 4 h.
  
  
  RESULTS
  In CVVH, CLTM did not differ between filter types. In CVVHD, tedizolid CLTM was significantly higher with the polysulfone hemodiafilter at Qd 6 l/h (p < 0.02). Tedizolid exhibited irreversible adsorption to the CRRT apparatus and bound significantly higher to the polysulfone hemodiafilter.
  
  
  CONCLUSIONS
  Tedizolid's CLTM is dependent on Qd, Quf, and hemodiafilter type. At conventional CRRT rates, tedizolid CLTM appears modest relative to total body clearance and is unlikely to require dose adjustments. CRRT adsorption in the clinical setting is likely less than what we observed in this in vitro, continuously recirculating blood model.
authors.affiliation: Department of Clinical, Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, USA.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Lewis
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Switaj
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Mueller
mesh_terms: D000327:Adsorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002417:Cattle; D015314:Dialysis Solutions; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D008657:Metabolic Clearance Rate; D023303:Oxazolidinones / Q000493:pharmacokinetics*; D006435:Renal Dialysis / Q000379:methods; D017582:Renal Replacement Therapy / Q000379:methods; D013777:Tetrazoles / Q000493:pharmacokinetics*; D013997:Time Factors; D014508:Urea / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D015314:Dialysis Solutions; D023303:Oxazolidinones; D013777:Tetrazoles; D014508:Urea; C546016:tedizolid