title: NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma.
abstract: A pivotal strategy to improve NK cell-mediated antitumor activity involves the upregulation of activating ligands on tumor cells. Enhancement of NK cell-mediated recognition of multiple myeloma cells was reported by us and others showing increased surface expression of NKG2D and DNAM-1 ligands on tumor cells following treatment with a number of chemotherapeutic agents, such as genotoxic drugs or inhibitors of proteasome, histone deacetylases, GSK3, and HSP-90. These compounds have the capability to affect tumor survival but also to activate specific transduction pathways associated with the upregulation of different NK cell activating ligands on the tumor cells. Here, we will summarize and discuss the molecular pathways whereby these drugs can regulate the expression of NK cell activating ligands in multiple myeloma cells.
authors.affiliation: Department of Molecular Medicine, Pasteur Cenci-Bolognetti Foundation Institute, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Fionda
authors.affiliation: Department of Molecular Medicine, Pasteur Cenci-Bolognetti Foundation Institute, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Soriani
authors.affiliation: Department of Molecular Medicine, Pasteur Cenci-Bolognetti Foundation Institute, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zingoni
authors.affiliation: Department of Molecular Medicine, Pasteur Cenci-Bolognetti Foundation Institute, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Santoni
authors.affiliation: Department of Molecular Medicine, Pasteur Cenci-Bolognetti Foundation Institute, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Cippitelli
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D006801:Humans; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000276:immunology*; D008024:Ligands; D058990:Molecular Targeted Therapy; D009101:Multiple Myeloma / Q000276:immunology* / Q000628:therapy*; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000378:metabolism*; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000098862:T Lineage-Specific Activation Antigen 1; D008024:Ligands; D055655:NK Cell Lectin-Like Receptor Subfamily K