title: The prognostic value of plasma thrombospondin-1 concentrations after aneurysmal subarachnoid hemorrhage.
abstract: BACKGROUND
  Thrombospondin-1 is a homotrimeric glycoprotein with well known functions in hemostasis and angiogenesis. Its expression was increased after experimental intracerebral hemorrhage. We determined whether increased plasma thrombospondin-1 concentrations are predictive of clinical outcomes of aneurysmal subarachnoid hemorrhage (aSAH).
  
  
  METHODS
  Plasma thrombospondin-1 concentrations of 118 aSAH patients and 118 age- and gender-matched healthy controls were determined using enzyme-linked immunosorbent assay. Patients were followed up until death or completion of 6months after aSAH. An unfavorable outcome was defined as Glasgow Outcome Scale score of 1-3. Multivariate analyses of significant variables of univariate analyses were performed to determine independent risk factors for the clinical outcomes.
  
  
  RESULTS
  Plasma thrombospondin-1 concentrations were significantly higher in aSAH patients than in healthy controls; plasma thrombospondin-1 concentrations were independently associated with clinical severity reflected by the World Federation of Neurological Surgeons score and Fisher score; thrombospondin-1 was identified as an independent predictor of 6-month mortality and 6-month unfavorable outcome; thrombospondin-1 had similar predictive performance compared with the World Federation of Neurological Surgeons score and Fisher score according to receiver operating characteristic curve analysis.
  
  
  CONCLUSIONS
  Higher plasma thrombospondin-1 concentrations are associated with clinical severity and long-term prognosis of aSAH patients.
authors.affiliation: Department of Neurosurgery, The Tumor Hospital of Hangzhou City, 34 Yanguan Lane, Hangzhou 310002, China.
authors.forename: Yong-Feng
authors.initials: YF
authors.lastname: Shen
authors.affiliation: Department of Neurosurgery, The Affiliated Zhongda Hospital of Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China. Electronic address: dxqhyy@163.com.
authors.forename: Xiao-Qiao
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Du
authors.affiliation: Department of Neurosurgery, The Tumor Hospital of Hangzhou City, 34 Yanguan Lane, Hangzhou 310002, China.
authors.forename: Ding-Bo
authors.initials: DB
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Yuan-Feng
authors.initials: YF
authors.lastname: Du
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Zu-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, The Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Che
authors.affiliation: Department of Neurosurgery, The Tumor Hospital of Hangzhou City, 34 Yanguan Lane, Hangzhou 310002, China.
authors.forename: Qun-Jie
authors.initials: QJ
authors.lastname: Liu
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000175:diagnosis*; D019700:Thrombospondin 1 / Q000097:blood*
chemical_list: D019700:Thrombospondin 1
keywords: Intracranial aneurysmal; Prognosis; Severity; Subarachnoid hemorrhage; Thrombospondin-1