title: Long non-coding RNAs in innate and adaptive immunity.
abstract: Long noncoding RNAs (lncRNAs) represent a newly discovered class of regulatory molecules that impact a variety of biological processes in cells and organ systems. In humans, it is estimated that there may be more than twice as many lncRNA genes than protein-coding genes. However, only a handful of lncRNAs have been analyzed in detail. In this review, we describe expression and functions of lncRNAs that have been demonstrated to impact innate and adaptive immunity. These emerging paradigms illustrate remarkably diverse mechanisms that lncRNAs utilize to impact the transcriptional programs of immune cells required to fight against pathogens and maintain normal health and homeostasis.
authors.affiliation: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, United States. Electronic address: tom.aune@vanderbilt.edu.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Aune
authors.affiliation: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, United States. Electronic address: chase.spurlock@vanderbilt.edu.
authors.forename: Charles F
authors.initials: CF
authors.lastname: Spurlock
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D062085:RNA, Long Noncoding / Q000235:genetics / Q000276:immunology*; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000235:genetics / Q000276:immunology*
chemical_list: D062085:RNA, Long Noncoding
keywords: Epigenetics; Immune system; Long non-coding RNA; Transcriptional regulation; Whole genome RNA-sequencing