title: Genetic variants identified by GWAS was associated with colorectal cancer in the Han Chinese population.
abstract: OBJECTIVE
  Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. Recently, genome-wide association studies have identified two single nucleotide polymorphisms (SNP) associated with CRC in Caucasians.
  
  
  METHODS
  To validate whether the same variations conferred risk to CRC in the Han Chinese population, we genotyped 760 individuals (380 controls and 380 cases samples) recruited from the Han Chinese origin.
  
  
  RESULTS
  We found rs11987193 in 8p12 (P = 0.0472 after correction, OR = 0.751) was significantly associated with CRC but rs12080929 in 1p33 (P = 0.0650 after correction, OR = 0.750) was not.
  
  
  CONCLUSIONS
  Our findings supported that rs11987193 is a susceptibility locus for CRC, and gene DUSP4 was possible to play a role in the pathology of CRC.
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Qiao
authors.forename: Chun-Yang
authors.initials: CY
authors.lastname: Zhang
authors.forename: Zhi-Long
authors.initials: ZL
authors.lastname: Yu
authors.forename: Qi-Min
authors.initials: QM
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: Department of Radiology, Medical College of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Cao
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors