title: Association between arsenic exposure and thyroid function: data from NHANES 2007-2010.
abstract: The association of arsenic variables in urine, total arsenic (UAS), arsenobetaine (UAB), dimethylarsinic acid (UDMA), and arsenic adjusted for arsenobetaine (UAAS) with thyroid-stimulating hormone (TSH), free and total serum thyroxine (FT4, TT4), free and total triiodothyronine (FT3, TT3), and thyroglobulin (TGN) was evaluated by analyzing data from 2007-2010 National Health and Nutrition Examination Survey. For iodine deficient males, there was a positive association between TSH and UDMA (p < 0.01) and a negative association between the levels of TT4 and UDMA (p < 0.01). Levels of UAAS were inversely associated with the levels of TT4 for both iodine-deficient (p = 0.054) and iodine-replete females (p < 0.01). For iodine-replete females, levels of both TSH and TGN increased with decrease in the levels of both UAB (p < 0.01) and UAS (p < 0.01). There was also a negative association between TSH and UAB as well as UAS (p < 0.01). For iodine-replete males, increased levels of UDMA were associated with decreasing levels of FT4 (p = 0.03).
authors.affiliation: a Private Consultant , Sanford , NC , USA.
authors.forename: Ram B
authors.initials: RB
authors.lastname: Jain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001151:Arsenic / Q000097:blood / Q000633:toxicity*; D001152:Arsenicals / Q000009:adverse effects / Q000097:blood; D002101:Cacodylic Acid / Q000097:blood / Q000633:toxicity; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D013954:Thyroglobulin / Q000097:blood; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014481:United States; D055815:Young Adult
chemical_list: D001152:Arsenicals; D014284:Triiodothyronine; D013972:Thyrotropin; D013954:Thyroglobulin; D002101:Cacodylic Acid; D001151:Arsenic; D013974:Thyroxine; C038992:arsenobetaine
keywords: arsenobetaine; dimethylarsinic acid; iodine sufficiency; smoking