title: Fetuin-A as a predicator of sarcopenic left ventricular dysfunction.
abstract: Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541 asymptomatic elderly (≥ 65 years) patients. Compared with non-sarcopenic population, FetA levels were significantly elevated in the ninety-two (17%) patients (79 ± 6 years; male: 34.7%) diagnosed with sarcopenia (621.1 ± 140.7 vs. 697.3 ± 179.6 μg/ml, < 0.001). Sarcopenic left ventricular dysfunction (S-LVD) was defined by the coexistence of sarcopenia and systolic impairment (LVEF < 50%) and 23 (4.3%) of them met the criteria. Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD). Conversely, in the group without sarcopenia, FetA levels were similar regardless of systolic function. Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD. In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.
authors.affiliation: 1] Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [2] Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan [3] Division of Cardiovascular Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Chang
authors.affiliation: Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Wei-Chuan
authors.initials: WC
authors.lastname: Tsai
authors.affiliation: Department of Family Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Chih-Hsing
authors.initials: CH
authors.lastname: Wu
authors.affiliation: College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yen-Wei
authors.initials: YW
authors.lastname: Lee
authors.affiliation: 1] Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [2] Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Tai
authors.affiliation: Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Yi-Heng
authors.initials: YH
authors.lastname: Li
authors.affiliation: Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Liang-Miin
authors.initials: LM
authors.lastname: Tsai
authors.affiliation: Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Jyh-Hong
authors.initials: JH
authors.lastname: Chen
authors.affiliation: 1] Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [2] Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ping-Yen
authors.initials: PY
authors.lastname: Liu
mesh_terms: D000368:Aged; D001823:Body Composition / Q000502:physiology; D003971:Diastole / Q000502:physiology; D005260:Female; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D055948:Sarcopenia / Q000378:metabolism*; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000378:metabolism* / Q000473:pathology*; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: C556354:AHSG protein, human; D060749:alpha-2-HS-Glycoprotein