title: Association between PDW and Long Term Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome.
abstract: BACKGROUND
  The aim of the present study was to perform a preliminary evaluation of the potential association between platelet distribution width (PDW) and frequency of major adverse cardiovascular events (MACEs) development in an observational study of acute coronary syndrome (ACS) patients.
  
  
  METHODS
  A total of 679 consecutive patients with ACS (498 (73.3%) males; mean age was 63.31±11.2 years; study population composed of 320 patients with acute myocardial infarction and 359 patients with unstable angina pectoris) subjected to primary percutaneous coronary intervention with transradial approach (TRA) were retrospectively enrolled to the study. Tertiles were formed based on PDW levels. The associations between PDW and in-hospital and long-term MACEs were analysed.
  
  
  RESULTS
  The frequencies of in-hospital instent thrombosis (P=0.05), long-term instent restenosis (P=0.005) and long-term total MACEs (P=0.008) were higher in tertiles having a high PDW value. In multivariate analyses, PDW was an independent predictor of in-hospital and long-term MACEs (odds ratio 1.081, 95% confidence interval 1.003-1.165; p=0.042). The projected Kaplan-Meier incidence of a MACEs in the PDW tertiles groups were 12.8%, 12.1%, and 21.6% at 40 months (respectively, p=0.003).
  
  
  CONCLUSIONS
  The pre-procedural PDW may be an independent predictor of both in-hospital and long-term adverse outcomes in patients with ACS.
authors.affiliation: Department of Cardiology, Mevlana University, Konya, Turkey.
authors.forename: Şeref
authors.initials: Ş
authors.lastname: Ulucan
authors.affiliation: Department of Cardiology, Mevlana University, Konya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Keser
authors.affiliation: Department of Cardiology, Mevlana University, Konya, Turkey. Electronic address: zeynettinkaya@yahoo.com.
authors.forename: Zeynettin
authors.initials: Z
authors.lastname: Kaya
authors.affiliation: Department of Cardiology, Mevlana University, Konya, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Katlandur
authors.affiliation: Department of Cardiology, Mevlana University, Konya, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Özdil
authors.affiliation: Department of Internal Medicine, Mevlana University, Konya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Bilgi
authors.affiliation: Department of Cardiology, Kazakh National University of S.D. Asfendiyarov, Almaty, Kazakhstan.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Ateş
authors.affiliation: Department of Cardiology, Mevlana University, Konya, Turkey.
authors.forename: Mehmet Sıddık
authors.initials: MS
authors.lastname: Ülgen
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000401:mortality / Q000601:surgery; D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000401:mortality / Q000601:surgery; D001792:Blood Platelets / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality / Q000601:surgery; D062645:Percutaneous Coronary Intervention; D012189:Retrospective Studies; D015996:Survival Rate; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000401:mortality
keywords: Acute coronary syndrome; Major adverse cardiac events; Platelet distribution width; Primary percutaneous coronary intervention; Transradial