title: Mechanical properties of a bioabsorbable nerve guide tube for long nerve defects.
abstract: The mechanical properties of nerve guide tubes must be taken into consideration when they are being developed. We previously reported the feasibility of using 50:50 tubes in a canine 40mm peroneal nerve defect model, where 50:50 represents the proportion of poly(L-lactic) acid (PLLA) and polyglycolic acid (PGA). The aim of the current study was to show that 50:50 tubes have suitable mechanical properties for repairing long nerve defects. Four types of nerve guide tubes made with PLLA to PGA fiber ratios of 100:0 (i.e. 100% PLLA) (100:0 tube), 50:50 (50:50 tube), 10:90 (10:90 tube), and 0:100 (0:100 tube) were designed and created using a tubular braiding machine. Their mechanical properties were examined in vitro (up to 16 weeks). In compression testing, 50:50 tubes had the highest normalized force value, followed in order by the 100:0, 10:90, and 0:100 tubes up to 8 weeks after immersion. From the point of view of biomechanics and bioresorbability, out of the 4 tube types tested, 50:50 tubes appeared to have the optimal mechanical properties for longer nerve defects.
authors.affiliation: Department of bioartificial organs, institute for frontier medical sciences, Kyoto university, Sakyo-ku, 606-8507 Kyoto, Japan; Hand surgery department, Strasbourg university hospitals, FMTS, university of Strasbourg, 67403 Illkirch, France; Department of orthopedic surgery, Juntendo university, 113-8421 Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ichihara
authors.affiliation: Hand surgery department, Strasbourg university hospitals, FMTS, university of Strasbourg, 67403 Illkirch, France.
authors.forename: S
authors.initials: S
authors.lastname: Facca
authors.affiliation: Hand surgery department, Strasbourg university hospitals, FMTS, university of Strasbourg, 67403 Illkirch, France. Electronic address: philippe.liverneaux@chru-strasbourg.fr.
authors.forename: P
authors.initials: P
authors.lastname: Liverneaux
authors.affiliation: Department of bioartificial organs, institute for frontier medical sciences, Kyoto university, Sakyo-ku, 606-8507 Kyoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Inada
authors.affiliation: Department of material chemistry, Kyoto university, Nishikyo-ku, 615-8150 Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takigawa
authors.affiliation: Department of orthopedic surgery, Juntendo university, 113-8421 Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.affiliation: Department of bioartificial organs, institute for frontier medical sciences, Kyoto university, Sakyo-ku, 606-8507 Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D008422:Materials Testing; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods; D010525:Peripheral Nerves / Q000601:surgery*; D011100:Polyglycolic Acid; D011474:Prosthesis Design
chemical_list: D001672:Biocompatible Materials; D011100:Polyglycolic Acid
keywords: Guide de repousse nerveuse; Mechanical properties; Nerve guide tube; PGA; PLLA; Propriétés mécaniques