title: Synthesis and bioactivity of nobilamide B.
abstract: An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B.Z-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.
authors.affiliation: Institute of Chemistry, College of Science, National Science Complex, University of the Philippines, Diliman, Quezon City, 1100, Philippines.
authors.forename: M P V
authors.initials: MP
authors.lastname: Jacinto
authors.affiliation: Marine Science Institute, College of Science, National Science Complex, University of the Philippines, Diliman, Quezon City, 1100, Philippines.
authors.forename: M S
authors.initials: MS
authors.lastname: Flores
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah UT 84112, United States.
authors.forename: Z
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Marine Science Institute, College of Science, National Science Complex, University of the Philippines, Diliman, Quezon City, 1100, Philippines.
authors.forename: G P
authors.initials: GP
authors.lastname: Concepcion
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah UT 84112, United States.
authors.forename: E W
authors.initials: EW
authors.lastname: Schmidt
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Faulkner
authors.affiliation: Institute of Chemistry, College of Science, National Science Complex, University of the Philippines, Diliman, Quezon City, 1100, Philippines.
authors.forename: A J L
authors.initials: AJ
authors.lastname: Villaraza