title: The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model.
abstract: C-peptide is produced, processed, and secreted with insulin, and appears to exert separate but intimately related effects. In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-peptide.
authors.affiliation: Department of Pharmacological and Physiological Science, St. Louis University School of Medicine, St. Louis, Missouri; and gyosten@slu.edu.
authors.forename: Gina L C
authors.initials: GL
authors.lastname: Yosten
authors.affiliation: Department of Pathology, St. Louis University School of Medicine, St. Louis, Missouri.
authors.forename: Grant R
authors.initials: GR
authors.lastname: Kolar
mesh_terms: D000818:Animals; D002096:C-Peptide / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000378:metabolism / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008954:Models, Biological; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D002096:C-Peptide; D007328:Insulin; D043562:Receptors, G-Protein-Coupled