title: New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity.
abstract: Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, including antitumor cytotoxic T lymphocytes CTLs. Therefore, strategies targeting both innate and adaptive pDC functions may improve antitumor T-cell immunity.
authors.affiliation: Department of Pathology and Immunology; University of Geneva Medical School ; Geneva, Switzerland.
authors.forename: Leslie
authors.initials: L
authors.lastname: Guéry
authors.affiliation: Department of Pathology and Immunology; University of Geneva Medical School ; Geneva, Switzerland.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Hugues
keywords:  antigen presentation; Th17; anti-tumor immunity; plasmacytoid dendritic cells