title: Choroidal neovascularisation as an unusual ophthalmic manifestation of cat-scratch disease in an 8-year-old girl.
abstract: To report the first case of choroidal neovascularisation (CNV) that appeared during the primary Bartonella henselae infection in an 8-year-old girl. An 8-year-old girl was referred to our clinic complaining of a central scotoma in the right eye. Fundus examination revealed a bilateral disc oedema and in the right eye neuroretinitis with macular star and CNV, which was confirmed by fluorescein angiography. The optical coherence tomography revealed the presence of macular serous retinal detachment. Laboratory analysis showed rising IgM and IgG titres for B. henselae. Cat-scratch disease was diagnosed, and an 8-week treatment with azithromycin was initiated. In addition, an intravitreal injection of ranibizumab was performed in the right eye to treat the CNV. A month later, we decided to administer a systemic antibiotic again for an additional 5 months, due to the persistence of papillitis. Cat-scratch disease should be considered among the different causes of inflammatory CNV secondary to infectious uveitis. Our case was the first described in the literature in which a CNV appeared during the primary infection and not as a later complication. The combination of systemic antibiotic treatment with intravitreal anti-VEGF therapy was a successful choice because it allowed us to obtain the complete resolution of neuroretinitis, associated with the scarring of the choroidal neovascular membrane, with a final visual acuity of 20/20 in both eyes.
authors.affiliation: Ocular Immunopathology Unit, Department of Ophthalmology, "Antonio Cardarelli" Hospital, Naples, Italy, loredana.latanza@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Latanza
authors.forename: F
authors.initials: F
authors.lastname: Viscogliosi
authors.forename: A
authors.initials: A
authors.lastname: Solimeo
authors.forename: F
authors.initials: F
authors.lastname: Calabrò
authors.forename: V
authors.initials: V
authors.lastname: De Angelis
authors.forename: P
authors.initials: P
authors.lastname: De Rosa
mesh_terms: D018416:Bartonella henselae / Q000302:isolation & purification; D002372:Cat-Scratch Disease / Q000150:complications*; D002648:Child; D020256:Choroidal Neovascularization / Q000382:microbiology*; D005260:Female; D006801:Humans; D012173:Retinitis / Q000382:microbiology; D041623:Tomography, Optical Coherence