title: TOX and CDKN2A/B Gene Polymorphisms Are Associated with Type 2 Diabetes in Han Chinese.
abstract: To study associations between type 2 diabetes (T2DM) candidate genes and microvascular complications of diabetes (MVCDs), we performed case-control association studies for both T2DM and MVCDs in Han Chinese subjects. We recruited 1,939 unrelated Han Chinese T2DM patients and 918 individuals with normal blood glucose levels as nondiabetic controls. Among T2DM patients, 1116 have MVCDs, 266 have a history of T2DM of >10 years but never developed MVCDs. Eighty-two single-nucleotide polymorphisms (SNPs) in 54 candidate genes were genotyped. Discrete association studies were performed by the PLINK program for T2DM and MVCDs. Significant associations were found among candidate gene SNPs and T2DM, including rs1526167 of the TOX gene (allele A, P = 2.85 × 10(-9), OR = 1.44). The SNP rs10811661 of the CDKN2A/B gene was also associated with T2DM (allele T, P = 4.09 × 10(-7), OR = 1.36). When we used control patients with >10 years of T2DM history without MVCD, we found that the G allele of SNP rs1526167 of the TOX gene was associated with MVCD (nominal P = 4.33 × 10(-4)). In our study, significant associations were found between TOX and CDKN2A/B gene SNPs and T2DM. The TOX polymorphism might account for the higher risk of T2DM and the lower risk of MVCDs in the Han Chinese population.
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Fengjiang
authors.initials: F
authors.lastname: Wei
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Chunyou
authors.initials: C
authors.lastname: Cai
authors.affiliation: Tianjin General Hospital, Tianjin Medical University, Tianjin, 300052, China.
authors.forename: Shuzhi
authors.initials: S
authors.lastname: Feng
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Lv
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.affiliation: Metabolic Diseases Hospital, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Baocheng
authors.initials: B
authors.lastname: Chang
authors.affiliation: Eye Hospital, Tianjin Medical University, Tianjin, 300384, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Shi
authors.affiliation: Tianjin General Hospital, Tianjin Medical University, Tianjin, 300052, China.
authors.forename: Hongling
authors.initials: H
authors.lastname: Han
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ling
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.affiliation: Eye Hospital, Tianjin Medical University, Tianjin, 300384, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Tianjin General Hospital, Tianjin Medical University, Tianjin, 300052, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Sun
authors.affiliation: Tianjin General Hospital, Tianjin Medical University, Tianjin, 300052, China.
authors.forename: Jianli
authors.initials: J
authors.lastname: Tian
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Hongxiao
authors.initials: H
authors.lastname: Jiao
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Fuhua
authors.initials: F
authors.lastname: Yang
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Mingshan
authors.initials: M
authors.lastname: Li
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zou
authors.affiliation: Eye Hospital, Tianjin Medical University, Tianjin, 300384, China.
authors.forename: Long
authors.initials: L
authors.lastname: Su
authors.affiliation: Tianjin People's Hospital, Department of Endocrinology, Tianjin, 300191, China.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Li
authors.affiliation: Tianjin General Hospital, Tianjin Medical University, Tianjin, 300052, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Li
authors.affiliation: Tianjin People's Hospital, Department of Endocrinology, Tianjin, 300191, China.
authors.forename: Huina
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Jingmin
authors.initials: J
authors.lastname: Shi
authors.affiliation: Tianjin General Hospital, Tianjin Medical University, Tianjin, 300052, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Liu
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Mingqin
authors.initials: M
authors.lastname: Chang
authors.affiliation: Tianjin People's Hospital, Department of Endocrinology, Tianjin, 300191, China.
authors.forename: Jingna
authors.initials: J
authors.lastname: Lin
authors.affiliation: Metabolic Diseases Hospital, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Chen
authors.affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Li
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006609:High Mobility Group Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C493966:CDKN2B protein, human; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16; D006609:High Mobility Group Proteins; C558851:TOX protein, human