title: Cytomegalovirus-associated ulceration of gastric conduit after chemoradiotherapy following esophagectomy for cancer.
abstract: A 64-year-old man underwent radical esophagectomy for cancer and simultaneous reconstruction using the gastric conduit through the posterior mediastinum. Two courses of adjuvant chemotherapy were performed. Twenty-eight months postoperatively, recurrence of the cancer was detected in the mediastinal lymph nodes, and he underwent concurrent chemoradiotherapy and boost chemotherapy. Endoscopy was then performed to investigate the cause of epigastralgia, and multiple ulcerations were found in the lesser curvature of the gastric conduit. Although a proton-pump inhibitor was orally administered, the ulceration was intractable. Re-examination of the original biopsy specimens and serological testing revealed positivity for cytomegalovirus. The ulcers began to heal after administration of foscarnet sodium. After the treatment, no signs of exacerbation associated with reinstitution of chemotherapy were observed.
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Matsuda
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kishida
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Miyamoto
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Okawa
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Fujiwara
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Ryoya
authors.initials: R
authors.lastname: Hashiba
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Eijiro
authors.initials: E
authors.lastname: Edagawa
authors.affiliation: Department of Diagnostic Pathology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Department of Diagnostic Pathology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Osawa
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585 Japan.
authors.forename: Harushi
authors.initials: H
authors.lastname: Osugi
keywords: Cytomegalovirus; Gastric conduit; Radical esophagectomy; Ulceration