title: Antidepressants with a high serotonin reuptake transporter affinity and serum lipid levels in a population-based study in older adults.
abstract: OBJECTIVE
  We aimed to investigate the association between antidepressants and serum lipid levels in a population-based study in older adults.
  
  
  METHODS
  We included participants from the prospective Rotterdam Study with data on lipid levels (total, low-density lipoprotein (LDL) and high-density lipoprotein cholesterol, and triglycerides). We classified antidepressants based on binding affinity to the serotonin transporter (low/intermediate- and high-affinity antidepressants). We compared lipid levels in users of these groups of antidepressants with lipid levels in non-users. Furthermore, we studied effect modification by the 102 C>T polymorphism (HTR2A gene), which is associated with antidepressant drug response and metabolic outcomes.
  
  
  RESULTS
  Compared with non-users (N = 6438), LDL cholesterol level was higher (2.9 versus 3.1 mmol/L, respectively; p = 0.05) in users of high-affinity antidepressants (N = 89). Similar levels of the other lipids were observed between the groups for the other lipids. The mean difference in serum LDL cholesterol level between non-users and users of high-affinity antidepressants was largest in participants with the CC genotype compared with the other genotypes (notably 0.47 mmol/L), indicative of effect modification (p-value for interaction = 0.03).
  
  
  CONCLUSIONS
  Antidepressants with a high serotonin reuptake transporter affinity were associated with higher LDL cholesterol levels, which were modified by a common genetic variation in the HTR2A gene.
authors.affiliation: Department of Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
authors.forename: Raymond
authors.initials: R
authors.lastname: Noordam
authors.affiliation: Department of Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
authors.forename: Nikkie
authors.initials: N
authors.lastname: Aarts
authors.affiliation: Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands The Health Care Inspectorate, The Hague, the Netherlands.
authors.forename: Catherine E
authors.initials: CE
authors.lastname: de Keyser
authors.affiliation: Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands The Health Care Inspectorate, The Hague, the Netherlands b.stricker@erasmusmc.nl.
authors.forename: Bruno H
authors.initials: BH
authors.lastname: Stricker
authors.affiliation: Department of Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands Apotheek Haagse Ziekenhuizen - HAGA, The Hague, the Netherlands.
authors.forename: Loes E
authors.initials: LE
authors.lastname: Visser
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
chemical_list: D000928:Antidepressive Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D050486:Serotonin Plasma Membrane Transport Proteins; D014280:Triglycerides; D012701:Serotonin
keywords: Cholesterol; Mendelian randomization analysis; antidepressants; serotonin receptor; single nucleotide polymorphism; triglycerides