title: Protective role of STING against gliomagenesis: Rational use of STING agonist in anti-glioma immunotherapy.
abstract: We recently reported that STING contributes to antiglioma immunity by triggering type I IFN induction in glioma microenvironment. Moreover, intratumoral administration of STING agonist improved the efficacy of peptide vaccination in a mouse glioma model, suggesting the rational use of STING agonists in the immunotherapy of brain tumor.
authors.affiliation: Department of Pathology, Asahikawa Medical University , Asahikawa, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ohkuri
authors.affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine , Pittsburgh, PA USA ; Cancer Virology Program, University of Pittsburgh Cancer Institute , Pittsburgh, PA USA.
authors.forename: Arundhati
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Department of Pathology, Asahikawa Medical University , Asahikawa, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Kosaka
authors.affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine , Pittsburgh, PA USA ; Department of Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA USA ; Cancer Virology Program, University of Pittsburgh Cancer Institute , Pittsburgh, PA USA.
authors.forename: Saumendra N
authors.initials: SN
authors.lastname: Sarkar
authors.affiliation: Department of Neurosurgery, University of California San Francisco , San Francisco, CA USA.
authors.forename: Hideho
authors.initials: H
authors.lastname: Okada
keywords: Immunotherapy; STING; glioma; type I IFNs