title: Understanding pharmaceutical polymorphic transformations II: crystallization variables and influence on dosage forms.
abstract: Excipients or formulation variables have often been exploited to improve stability, modify release, or improve physicochemical properties of dosage forms. In pharmaceutical field, it is generally expected that excipients work at macromolecular level where they might influence the crystal structure of a solid. These polymers/colloidal particles may modify the rate and direction of crystal growth. It has also been observed, that different polymorphic crystals exhibit different colors on exposure to same colorant, predominantly due to difference in surface pH of different crystal lattices. Apart from physicochemical affect, crystal habit also influences pharmacokinetic parameters of the dosage form. Crystals with smaller size or lower lattice energy have shown to exhibit higher bioavailability with faster rate of release.
authors.affiliation: Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, Punjab, India.
authors.forename: Jatin
authors.initials: J
authors.lastname: Sood
authors.affiliation: Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, Punjab, India.
authors.forename: Bharti
authors.initials: B
authors.lastname: Sapra
authors.affiliation: Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, Punjab, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Bhandari
authors.affiliation: Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, Punjab, India.
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Tiwary
mesh_terms: D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D010599:Pharmacokinetics; D012997:Solvents / Q000737:chemistry; D013696:Temperature
chemical_list: D005079:Excipients; D012997:Solvents