title: Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease.
abstract: Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine that has been studied extensively in atopic diseases and more recently in various rheumatic disorders. It is involved in T cell development in the thymus and promotes homeostatic T cell expansion by classical dendritic cells. However, deregulated TSLP expression in various rheumatic diseases has implicated this cytokine as a strong mediator in immunopathology. Overexpressed TSLP induces strong T cell activation and production of pro-inflammatory cytokines in human cells and animal models for RA, SSc and LN, underscoring the therapeutic potential of targeting the TSLP-TSLP receptor axis.
authors.affiliation: Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Maarten R
authors.initials: MR
authors.lastname: Hillen
authors.affiliation: Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Timothy R D J
authors.initials: TR
authors.lastname: Radstake
authors.affiliation: Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Cornelis E
authors.initials: CE
authors.lastname: Hack
authors.affiliation: Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands j.vanroon@umcutrecht.nl.
authors.forename: Joel A G
authors.initials: JA
authors.lastname: van Roon
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology*; D003713:Dendritic Cells / Q000473:pathology / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D012216:Rheumatic Diseases / Q000473:pathology* / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000473:pathology / Q000502:physiology; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D000094632:Thymic Stromal Lymphopoietin
keywords: T cells; dendritic cells; immunopathology; thymic stromal lymphopoietin