title: Have You Ever Seen the Impact of Crossing Fiber in DTI?: Demonstration of the Corticospinal Tract Pathway.
abstract: OBJECTIVE
  The identification of the corticospinal tract (CST) pathway with a deterministic fiber tracking approach is limited because of crossing fibers, especially for the hand fibers of the CST due to the crossing superior longitudinal fasciculus (SLF). We examined a patient with congenital bilateral perisylvian syndrome (CBPS) who did not have the SLF, in order to visualize CST hand fibers that were not affected by crossing fibers.
  
  
  METHODS
  A 10-year-old girl without the SLF due to CBPS and three normal healthy subjects participated in this study. We used a deterministic fiber tracking algorithm, and the regions of interest (ROIs) were drawn in the posterior limb of internal capsule (PLIC) and the primary motor cortex. The apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative anisotropy (RA), and volume ratio (VR) were measured based on the extracted fiber tracts.
  
  
  RESULTS
  The ADC values were not different between the normal subjects and the patient with CBPS. The FA, RA, and VR values of the normal subjects were similar, but were relatively higher than those of the patient with CBPS.
  
  
  CONCLUSIONS
  Our results clearly show the impact of the crossing fiber for the hand motor fibers of the CST pathway with deterministic tracking algorithms in diffusion tensor tractography.
authors.affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Physical Therapy, Catholic University of Daegu, Gyeongbuk-do, Republic of Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Park
authors.affiliation: Department of Physical Medicine and Rehabilitation, Chonbuk National University, Jeollabuk-do, Republic of Korea.
authors.forename: Sung-Hee
authors.initials: SH
authors.lastname: Park
authors.affiliation: Center for Medical Metrology, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea.
authors.forename: Cheolpyo
authors.initials: C
authors.lastname: Hong
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D016880:Anisotropy; D016022:Case-Control Studies; D054022:Cerebrum / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D056324:Diffusion Tensor Imaging; D005260:Female; D006225:Hand / Q000294:innervation / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D054220:Malformations of Cortical Development / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D009044:Motor Cortex / Q000473:pathology* / Q000503:physiopathology; D009412:Nerve Fibers / Q000473:pathology*; D011712:Pyramidal Tracts / Q000473:pathology* / Q000503:physiopathology