title: Pharmacokinetics and Tolerability of Intravenous Sildenafil in Two Subjects with Child-Turcotte-Pugh Class C Cirrhosis and Renal Dysfunction.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S. Greene Street, N3W50, Baltimore, MD, 21201, USA. amindiko@medicine.umaryland.edu.
authors.forename: Ayse L
authors.initials: AL
authors.lastname: Mindikoglu
authors.affiliation: College of Pharmacy, Ferris State University, Grand Rapids, MI, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Dowling
authors.affiliation: Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Schaub
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S. Greene Street, N3W50, Baltimore, MD, 21201, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Hutson
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S. Greene Street, N3W50, Baltimore, MD, 21201, USA.
authors.forename: Darryn R
authors.initials: DR
authors.lastname: Potosky
authors.affiliation: Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Christenson
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Rolf N
authors.initials: RN
authors.lastname: Barth
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: LaMattina
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Steven I
authors.initials: SI
authors.lastname: Hanish
authors.affiliation: Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Weir
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S. Greene Street, N3W50, Baltimore, MD, 21201, USA.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Raufman
mesh_terms: D016903:Drug Monitoring; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D012720:Severity of Illness Index; D000068677:Sildenafil Citrate / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D016896:Treatment Outcome
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D000068677:Sildenafil Citrate
keywords: Cirrhosis; Pharmacokinetics; Renal dysfunction; Sildenafil