title: Olefin Preparation via Palladium-Catalyzed Oxidative De-Azotative and De-Sulfitative Internal Cross-Coupling of Sulfonylhydrazones.
abstract: A novel reactivity of sulfonylhydrazones under Pd catalysis is described, where SO2 and N2 are formally extruded to afford the product of an apparent internal coupling reaction. The reaction is effective with both carbocyclic and heterocyclic aromatic precursors.
authors.affiliation: †Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201600, P. R. China.|§STA Pharmaceuticals, 288 Fute Zhong Road, Shanghai 200131, P. R. China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Tan
authors.affiliation: ‡Janssen Pharmaceutica, API Development, Turnhoutseweg 30, 2340 Beerse, Belgium.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Houpis
authors.affiliation: §STA Pharmaceuticals, 288 Fute Zhong Road, Shanghai 200131, P. R. China.
authors.forename: Renmao
authors.initials: R
authors.lastname: Liu
authors.affiliation: §STA Pharmaceuticals, 288 Fute Zhong Road, Shanghai 200131, P. R. China.
authors.forename: Youchu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: †Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201600, P. R. China.
authors.forename: Zhilong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D006571:Heterocyclic Compounds; D006835:Hydrazones; D013438:Sulfhydryl Compounds; D010165:Palladium