title: Hepatitis A seroprevalence in preschool children in Assis Brazil, Acre, Brazil, in 2003 and 2010.
abstract: BACKGROUND
  The Amazon region has the highest seroprevalence of hepatitis A virus (HAV) in Brazil.
  
  
  METHODS
  In the present study, the seroprevalence of total HAV antibodies in two groups, composed of 147 and 254 children between 1 and 5 years old in Assis Brasil, Acre, was measured in 2003 and 2010, respectively, and compared with socio-economic changes in the city.
  
  
  RESULTS
  In 2003, the HAV seroprevalence rate was 26.5%, while in 2010, it was 22.4%. There was an overall improvement in socio-economic and sanitary conditions, with the exception of open sewage. In 2003, factors associated with positive serology were child age (aOR [adjusted odds ratio] 1.84; 95% CI: 1.28-2.64), having a latrine or not having a toilet at home (aOR 4.73; 95% CI: 1.06-21.17) and the treatment of drinking water with chlorine (aOR 0.26; 95% CI: 0.07-0.92). In 2010, the main factors associated with positive serology were using rivers, streams and rainwater as sources of water for domestic purposes (aOR 24.36; 95% CI: 3.69-160.85); having a wooden or ground floor at home (OR 2.51; 95% CI: 1.11-5.69) and child age (aOR 2.33; 95% CI: 1.66-3.28).
  
  
  CONCLUSIONS
  In the Brazilian Amazon, sanitation and water treatment still require improvement and socio-economic development is warranted in order to decrease hepatitis A transmission.
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Thasciany M
authors.initials: TM
authors.lastname: Pereira
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Saulo A S
authors.initials: SA
authors.lastname: Mantovani
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Fernando L C C
authors.initials: FL
authors.lastname: Branco
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Athos M
authors.initials: AM
authors.lastname: Braña
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Humberto
authors.initials: H
authors.lastname: Oliart-Guzmán
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Breno M
authors.initials: BM
authors.lastname: Delfino
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Martins
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Thiago S
authors.initials: TS
authors.lastname: Araújo
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Cristieli S M
authors.initials: CS
authors.lastname: Oliveira
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769.
authors.forename: Pascoal T
authors.initials: PT
authors.lastname: Muniz
authors.affiliation: Health Sciences Center, Federal University of Acre, BR 364 km 04, Distrito Industrial, Rio Branco, Acre, Brazil, 69919-769 msnunes1@yahoo.com.br.
authors.forename: Mônica
authors.initials: M
authors.lastname: da Silva-Nunes
mesh_terms: D017677:Age Distribution; D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D060766:Drinking Water; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology*; D035922:Hepatitis A Antibodies / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D016017:Odds Ratio; D012499:Sanitation; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors
chemical_list: D060766:Drinking Water; D035922:Hepatitis A Antibodies
keywords: Amazon; Children; Hepatitis A; Sanitation; Water usage