title: Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography.
abstract: Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation.
authors.affiliation: Department of Bioengineering, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Eberle
authors.affiliation: Division of Biomedical Sciences, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
authors.forename: Mike S
authors.initials: MS
authors.lastname: Hsu
authors.affiliation: Department of Bioengineering, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
authors.forename: Carissa L
authors.initials: CL
authors.lastname: Rodriguez
authors.affiliation: Division of Biomedical Sciences, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
authors.forename: Jenny I
authors.initials: JI
authors.lastname: Szu
authors.affiliation: Department of Bioengineering, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Oliveira
authors.affiliation: Division of Biomedical Sciences, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
authors.forename: Devin K
authors.initials: DK
authors.lastname: Binder
authors.affiliation: Department of Bioengineering, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
authors.forename: B Hyle
authors.initials: BH
authors.lastname: Park
keywords: (100.2960) Image analysis; (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging