title: Interactome analysis brings splicing into focus.
abstract: The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing.Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Dominguez
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. cburge@mit.edu.|Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. cburge@mit.edu.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Burge
mesh_terms: D017398:Alternative Splicing; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000378:metabolism*; D006801:Humans; D000068103:Serine-Arginine Splicing Factors / Q000378:metabolism*; D017381:Spliceosomes / Q000378:metabolism*
chemical_list: D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; C000595779:SRSF1 protein, human; D000068103:Serine-Arginine Splicing Factors