title: Therapeutic Whole-Lung Lavage for Pulmonary Alveolar Proteinosis: A Procedural Update.
abstract: Pulmonary alveolar proteinosis is a disease caused by increased accumulation and impaired clearance of surfactant by alveolar macrophages. This narrative review summarizes the role of therapeutic whole-lung lavage in the management of pulmonary alveolar proteinosis. We describe the preprocedural evaluation, indications, and anesthetic considerations, along with step-by step technical aspects of the procedure, postoperative recovery, potential complications, and long-term outcomes.
authors.affiliation: Departments of *General Anesthesiology and Outcomes Research †Critical Care Anesthesiology, Anesthesiology Institute ‡Respiratory Institute, Cleveland Clinic, Cleveland, OH.
authors.forename: Basem B
authors.initials: BB
authors.lastname: Abdelmalak
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Khanna
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Culver
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Popovich
mesh_terms: D018893:Bronchoalveolar Lavage / Q000009:adverse effects / Q000379:methods*; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000503:physiopathology / Q000628:therapy*; D009873:Operating Rooms; D011649:Pulmonary Alveolar Proteinosis / Q000503:physiopathology / Q000628:therapy*