title: Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia.
abstract: We observed a case of recombinant human erythropoietin resistance caused by Gastric Antral Vascular Ectasia in a 40-year-old female with ESRD on hemodialysis. Some associated factors such as autoimmune disease, hemolysis, heart and liver disease were discarded on physical examination and complementary tests. The diagnosis is based on the clinical history and endoscopic appearance of watermelon stomach. The histologic findings are fibromuscular proliferation and capillary ectasia with microvascular thrombosis of the lamina propria. However, these histologic findings are not necessary to confirm the diagnosis. Gastric Antral Vascular Ectasia is a serious condition and should be considered in ESRD patients on hemodialysis with anemia and resistance to recombinant human erythropoietin because GAVE is potentially curable with specific endoscopic treatment method or through surgical procedure.
authors.affiliation: Escola Paulista de Medicina, UNIFESP, Brazil.
authors.forename: Desiree Ji Re
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: Hospital do Rim, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Fragata
authors.affiliation: Escola Paulista de Medicina, UNIFESP, Brazil.
authors.forename: José Osmar Medina
authors.initials: JO
authors.lastname: Pestana
authors.affiliation: Escola Paulista de Medicina, UNIFESP, Brazil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Draibe
authors.affiliation: Escola Paulista de Medicina, UNIFESP, Brazil.
authors.forename: Maria Eugênia
authors.initials: ME
authors.lastname: Canziani
authors.affiliation: Escola Paulista de Medicina, UNIFESP, Brazil.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cendoroglo
authors.affiliation: Escola Paulista de Medicina, UNIFESP, Brazil.
authors.forename: Miguel Ângelo
authors.initials: MÂ
authors.lastname: de Góes
mesh_terms: D000328:Adult; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology*; D004351:Drug Resistance; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D020252:Gastric Antral Vascular Ectasia / Q000150:complications*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*
chemical_list: C554270:EPO protein, human; D004921:Erythropoietin