title: Single nucleotide polymorphisms near IL28B gene and response to treatment of chronic hepatitis C in hemodialysis patients.
abstract: BACKGROUND
  It has been shown that single nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) gene were associated with sustained virological response following standard antivirological treatment of chronic hepatitis C.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the association between SNPs near the IL28B gene and response to the treatment of chronic hepatitis C in hemodialysis patients.
  
  
  METHODS
  The study group included 24 hemodialysis patients with chronic hepatitis C routinely treated with pegylated interferon α-2 a. HCV genotype 1 was the cause of chronic hepatitis C in all study participants. Sustained virological response was determined by an assay with a sensitivity of 20 IU/mL, 6 months after completion of the antivirological treatment. The genotyping of the three most widely studied IL28B gene polymorphisms (rs12979860, rs8099917, and rs12980275) was performed in all study participants.
  
  
  RESULTS
  Sustained virological response was achieved in 50% of the treated patients. The treatment response was significantly associated with the CC genotype of rs12979860, TT genotype of rs8099917, and AA genotype of rs12980275 (p = 0.003, p = 0.009, and p = 0.012, respectively).
  
  
  CONCLUSIONS
  The three most widely studied SNPs near the IL28B gene were associated with sustained virological response following antivirological treatment of chronic hepatitis C in hemodialysis patients.
authors.affiliation: a Department of Dialysis , University Hospital of Nephrology , Skopje , R. Macedonia .
authors.forename: Pavlina
authors.initials: P
authors.lastname: Dzekova-Vidimliski
authors.affiliation: a Department of Dialysis , University Hospital of Nephrology , Skopje , R. Macedonia .
authors.forename: Igor G
authors.initials: IG
authors.lastname: Nikolov
authors.affiliation: b Faculty of Pharmacy , University "Ss Cyril and Methodius" , Skopje , R. Macedonia .
authors.forename: Nadica
authors.initials: N
authors.lastname: Matevska-Geshkovska
authors.affiliation: c Special Hospital for Nephrology and Dialysis , Struga , R. Macedonia , and.
authors.forename: Sami
authors.initials: S
authors.lastname: Mena
authors.affiliation: d Department of Nephrology , Dialysis and Organ Transplantation , CHU Rangueil , Toulouse , France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
authors.affiliation: b Faculty of Pharmacy , University "Ss Cyril and Methodius" , Skopje , R. Macedonia .
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Dimovski
authors.affiliation: a Department of Dialysis , University Hospital of Nephrology , Skopje , R. Macedonia .
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Sikole
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis / Q000379:methods; D012254:Ribavirin / Q000627:therapeutic use*; D019562:Viral Load; D000095022:Interferon Lambda
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D007372:Interferons; D007378:Interleukins; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D012254:Ribavirin; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C100416:peginterferon alfa-2a
keywords: Hemodialysis; IFN-lambda-3 protein; hepatitis C chronic; single nucleotide polymorphisms; treatment