title: INPP4B Is a Tumor Suppressor in the Context of PTEN Deficiency.
abstract: Enzymes (PI3K and PTEN) controlling cellular levels of 3-phosphorylated phosphoinositides are known as important drivers or suppressors of tumorigenesis in various cancers. In this issue of Cancer Discovery, Kofuji and colleagues and Chew and colleagues identify the lipid phosphatase INPP4B as a context-specific tumor suppressor that controls phosphoinositide levels and AKT2 activation in PTEN-deficient cells.
authors.affiliation: Department of Molecular Biology & Biochemistry, University of California, Irvine, California.
authors.forename: Thanh-Trang T
authors.initials: TT
authors.lastname: Vo
authors.affiliation: Department of Molecular Biology & Biochemistry, University of California, Irvine, California. dfruman@uci.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Fruman
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology*; D000818:Animals; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D051059:PTEN Phosphohydrolase / Q000172:deficiency*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D018129:Phosphatidylinositol Phosphates; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase