title: Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications.
abstract: The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers valuable features for photodynamic therapy such as remarkable cellular selectivity, rapid cell uptake by receptor-mediated endocytosis, efficient generation of (1)O2 upon irradiation, potent phototoxicity as well as low cytotoxicity in the "off"-state.
authors.affiliation: Institute of Organic Chemistry III, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. David.Ng@uni-ulm.de Tanja.Weil@uni-ulm.de.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Natalia
authors.initials: N
authors.lastname: Zabarska
authors.forename: Yuzhou
authors.initials: Y
authors.lastname: Wu
authors.forename: Markus
authors.initials: M
authors.lastname: Lamla
authors.forename: Stephan
authors.initials: S
authors.lastname: Fischer
authors.forename: Katharina
authors.initials: K
authors.lastname: Monczak
authors.forename: David Y W
authors.initials: DY
authors.lastname: Ng
authors.forename: Sven
authors.initials: S
authors.lastname: Rau
authors.forename: Tanja
authors.initials: T
authors.lastname: Weil
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D004705:Endocytosis; D006801:Humans; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D017481:Receptors, Somatostatin / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry*; D026082:Singlet Oxygen / Q000378:metabolism; D013004:Somatostatin / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D056831:Coordination Complexes; D017319:Photosensitizing Agents; D017481:Receptors, Somatostatin; D026082:Singlet Oxygen; D013004:Somatostatin; D012428:Ruthenium