title: [Vacuolar H(+)-ATPase and the Secondary Transporters: Their Identification, Mechanism, Function and Physiological Relevance].
abstract: Eukaryotic cells possess acidic compartments with pH ranging from 0.1-6.5. Studies in the last couple of decades indicated that the acid pool is established by vacuolar proton ATPase, and is essential for various physiological and pathological processes. I have identified the vacuolar ATPase as well as several secondary transporters which are energetically coupled with vacuolar ATPase. I have also established the protocol for analysis of the structure and function of transporter proteins applicable to essentially all known transporters. In this article, I am going to summarize this study and describe some topics.
authors.affiliation: Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Moriyama
mesh_terms: D000818:Animals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008565:Membrane Proteins / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000502:physiology*; D017494:Proton Pumps; D025262:Vacuolar Proton-Translocating ATPases / Q000502:physiology*
chemical_list: D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D017494:Proton Pumps; D025262:Vacuolar Proton-Translocating ATPases