title: The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland.
abstract: BACKGROUND
  Psoriasis is an inflammatory disease in which joints involvement may be insidious and difficult to detect. Bone and cartilage biomarkers may be helpful in screening patients with psoriasis for psoriatic arthritis (PsA).
  
  
  OBJECTIVE
  To assess bone and cartilage serum biomarkers in psoriasis. Methods. The study was conducted in 2014 and included 61 psoriatic patients and 30 healthy individuals. In both groups, the serum concentrations of soluble receptor activator of nuclear factor-κB ligand (sRANKL), cartilage oligomeric matrix protein (COMP), osteoprotegerin (OPG), and interleukin-20 (IL-20) were examined. Severity of skin lesions was assessed by Psoriasis Area and Severity Index (PASI), body surface area (BSA), and Physician Global Assessment (PGA) scores.
  
  
  RESULTS
  The duration of psoriasis was from 1 year to 45 years. 22 patients suffered from concomitant PsA. The mean value of PASI was 23.1 ± 12.0 and BSA was 27.6 ± 20.6%. COMP, OPG, and IL-20 concentrations in psoriatic patients were significantly higher than in the control group. OPG/sRANKL ratio was significantly lower in PsA patients than in psoriatic patients without arthritis.
  
  
  CONCLUSIONS
  Results of the conducted study suggest that COMP, OPG, IL-20, and OPG/sRANKL ratio may appear useful biomarkers of bone and cartilage involvement in psoriasis.
authors.affiliation: Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Bartosińska
authors.affiliation: Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Michalak-Stoma
authors.affiliation: Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Juszkiewicz-Borowiec
authors.affiliation: Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kowal
authors.affiliation: Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Chodorowska
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001830:Body Surface Area; D064236:Cartilage Oligomeric Matrix Protein / Q000097:blood*; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D011565:Psoriasis / Q000097:blood*; D053245:RANK Ligand / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D007378:Interleukins; D053244:Osteoprotegerin; D053245:RANK Ligand; C505688:TNFSF11 protein, human; C422042:interleukin 20; C577553:TSP5 protein, human