title: Protective effect of probiotics in the treatment of infantile eczema.
abstract: The aim of the present study was to provide evidence for the application of probiotics in the prevention and treatment of infantile eczema by exploring changes in the intestinalBifidobacterialevels and the Scoring Atopic Dermatitis (SCORAD) index prior and subsequent to treatment with probiotics in infants with eczema. A total of 40 infants with eczema were randomly divided into treatment and control groups. Prior and subsequent to the treatment, the SCORAD index was evaluated and the content ofBifidobacterium bifidumin the stool of each infant in the two groups was quantified using 16S rRNA/DNA quantitative polymerase chain reaction analysis. After four weeks of treatment withB. bifidumtriple viable capsules, the levels ofB. bifidumincreased sharply (P<0.05) and the SCORAD index was notably reduced (P<0.05) as compared with the values prior to treatment. By contrast, neither the content ofB. bifidumnor the SCORAD index changed significantly in the control group after four weeks (P>0.05). Following treatment, the levels ofB. bifidumin the stools of the treatment group were significantly higher than those in the stools of the control group (P<0.05), and the SCORAD index was significantly lower than that of the control group (P<0.05). In conclusion, probiotic supplementation has a positive effect on the prevention and treatment of infantile eczema.
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266071, P.R. China.
authors.forename: Rong-Jun
authors.initials: RJ
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, The Maternal-Child Healthcare Center of Qingdao, Qingdao, Shandong 266035, P.R. China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Qiu
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266071, P.R. China.
authors.forename: Ren-Zheng
authors.initials: RZ
authors.lastname: Guan
authors.affiliation: Department of Pediatrics, The Maternal-Child Healthcare Center of Qingdao, Qingdao, Shandong 266035, P.R. China.
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Hu
authors.affiliation: Department of Pediatrics, The Maternal-Child Healthcare Center of Qingdao, Qingdao, Shandong 266035, P.R. China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Shandong Traffic hospital, Jinan, Shandong 250031, P.R. China.
authors.forename: Guang-Jun
authors.initials: GJ
authors.lastname: Wang
keywords: Bacillus bifidus; eczema; infants; probiotics