title: Synthesis and antiproliferative activity of pterostilbene and 3′-methoxy pterostilbene Mannich base derivatives against Hela cells.
abstract: Fourteen novel pterostilbene (1) and [Formula: see text]-methoxy pterostilbene (2) Mannich base derivatives (3-16) were synthesized via the microwave-assisted Mannich reaction of 1 or 2 with various secondary amines and formaldehyde. The regioselectivity of the reaction occurred preferentially at [Formula: see text] position of the B-ring of stilbene. The biological testing results showed that all the target compounds exhibit antiproliferative activity against Hela cells from [Formula: see text]-[Formula: see text]. Compounds 1-3, 7, 11-13, and 16 displayed higher (lower [Formula: see text] values) activity than the positive control cisplatin [Formula: see text].
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
authors.forename: Chongyang
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
authors.forename: Linpei
authors.initials: L
authors.lastname: Dong
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
authors.forename: Shengchun
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China. wangqa@hnu.edu.cn.
authors.forename: Qiuan
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D049109:Cell Proliferation / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008352:Mannich Bases; D015394:Molecular Structure; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D008352:Mannich Bases; D013267:Stilbenes; C107773:pterostilbene
keywords: -Methoxy pterostilbene; Antiproliferative activity; Hela cells; Mannich base derivatives; Pterostilbene; Synthesis