title: Anticancer effect and mechanism of a Se-modified porphyrin Au(III) complex.
abstract: Au, Se and porphyrin are widely used components in the design of anticancer drugs, but their combination has never been referred to. In this work, a Se-modified porphyrin Au(III) complex, [AuTPP-Se]Cl, was designed and synthesized as a potential anticancer agent. This compound exhibits remarkable antiproliferative activity on all the six tested cancer cells. Its potency on HepG2 is even ten times higher than that of CDDP. The synergistic action among Au, Se and porphyrin components was validated. Mechanism study showed that both the induction of mitochondria-dependent apoptosis and the arrest of cell cycle contribute to the anticancer activity of [AuTPP-Se]Cl.
authors.affiliation: Department of Pharmacology, Tianjin Medical University, No. 22 of Qixiangtai Road, Tianjin 300070, China.
authors.forename: Feng-Rui
authors.initials: FR
authors.lastname: Yang
authors.affiliation: Department of Chemistry, Nankai University, No. 94 of Weijin Road, Tianjin 300071, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry, Nankai University, No. 94 of Weijin Road, Tianjin 300071, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, Tianjin Medical University, No. 22 of Qixiangtai Road, Tianjin 300070, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Nankai University, No. 94 of Weijin Road, Tianjin 300071, China.
authors.forename: Hong-Rui
authors.initials: HR
authors.lastname: Guo
authors.affiliation: Department of Chemistry, Nankai University, No. 94 of Weijin Road, Tianjin 300071, China. Electronic address: wjruan@nankai.edu.cn.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Ruan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D050607:Organogold Compounds / Q000737:chemistry* / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology; D018036:Selenium Compounds / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D050607:Organogold Compounds; D011166:Porphyrins; D018036:Selenium Compounds
keywords: Anticancer; Cell cycle arrest; Mitochondria-dependent apoptosis; Synergetic action; [AuTPP-Se]Cl