title: SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL FUSED THIAZOLO[3,2A]PYRIMIDINES AS POTENTIAL ANALGESIC AND ANTI-INFLAMMATORY AGENTS.
abstract: Some novel bicyclic thiazolopyrimidine derivatives bearing various substituents have been synthesized through one-pot three-component method. Structures of the target compounds were confirmed by elemental analysis and spectral data. Some selected members of the newly synthesized compounds were investigated for their analgesic and anti-inflammatory activities and revealed pronounced anti-inflammatory activity greater than that of indomethacin (reference drug).
authors.forename: Nagy M
authors.initials: NM
authors.lastname: Khalifa
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Al-Omar
authors.forename: Abd El-Galil E
authors.initials: Ael-G
authors.lastname: Amr
authors.forename: Ayman R
authors.initials: AR
authors.lastname: Baiuomy
authors.forename: Rehab F
authors.initials: RF
authors.lastname: Abdel-Rahman
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004341:Drug Evaluation; D005260:Female; D008297:Male; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011743:Pyrimidines; D013844:Thiazoles