title: Effect of the Combination of Hemodialysis and  Hemoperfusion on Clearing Advanced Glycation  End Products: A Prospective, Randomized,  Two-Stage Crossover Trial in Patients Under  Maintenance Hemodialysis.
abstract: Advanced glycation end products (AGEs) are protein-bound uremic toxins and are elevated in patients with the end-stage of renal disease. The present study sought to develop an effective method to remove the circulating AGEs from patients using the combination of hemodialysis (HD) and hemoperfusion (HP). Thirty-six patients undergoing maintenance HD for 3 months were randomly divided into two groups. Patients in Group 1 received HD, followed by the combined HP + HD treatment once, whereas patients in Group 2 were first treated with HP + HD and then they received the HD treatment alone. Patients treated with HD alone did not alter higher levels of serum AGEs. In contrast, patients treated with the combined HP + HD exhibited significantly lower levels of serum AGEs and TNF-α. Results from this study demonstrate that the combination of HD + HP treatment may be an effective and better approach to remove the protein-bound uremic toxins and inflammatory cytokines.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chang-Lin
authors.initials: CL
authors.lastname: Mei
authors.forename: Shu
authors.initials: S
authors.lastname: Rong
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Liu
authors.forename: Guan-Qing
authors.initials: GQ
authors.lastname: Xiao
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Shao
authors.forename: Yao-Zhong
authors.initials: YZ
authors.lastname: Kong
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D018592:Cross-Over Studies; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006464:Hemoperfusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D014511:Uremia / Q000097:blood / Q000473:pathology / Q000628:therapy*
chemical_list: D017127:Glycation End Products, Advanced; D014409:Tumor Necrosis Factor-alpha