title: Treatment failure by canakinumab in a patient with progressive multisystemic Erdheim-Chester disease refractory to anakinra: successful use of vemurafenib.
authors.affiliation: Vasculitis Center, Department of Rheumatology and Clinical Immunology, Klinikum Bad Bramstedt and University Medical Center Schleswig-Holstein, Bad Bramstedt and j.schirmer@klinikumbb.de.
authors.forename: Jan H
authors.initials: JH
authors.lastname: Schirmer
authors.affiliation: Institute for Pathology, University of Lübeck and University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Thorns
authors.affiliation: Vasculitis Center, Department of Rheumatology and Clinical Immunology, Klinikum Bad Bramstedt and University Medical Center Schleswig-Holstein, Bad Bramstedt and.
authors.forename: Frank
authors.initials: F
authors.lastname: Moosig
authors.affiliation: Vasculitis Center, Department of Rheumatology and Clinical Immunology, Klinikum Bad Bramstedt and University Medical Center Schleswig-Holstein, Bad Bramstedt and.
authors.forename: Julia U
authors.initials: JU
authors.lastname: Holle
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D031249:Erdheim-Chester Disease / Q000188:drug therapy*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors*; D008297:Male; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D012074:Remission Induction; D013449:Sulfonamides / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome; D000077484:Vemurafenib
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D007211:Indoles; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D047428:Protein Kinase Inhibitors; D013449:Sulfonamides; D000077484:Vemurafenib; C541220:canakinumab