title: Self-assembly induced solubilization of drug-like molecules in nanostructured ionic liquids.
abstract: Here we report a novel self-assembly induced solubilization strategy with nanostructured ionic liquids as solvents. Highly ordered mesoscopic structures featuring the solute as a key component, such as liquid crystals, were formed via self-assembly in nanostructured long-chain carboxylate ionic liquids, resulting in extremely high solubilities for sparingly soluble drug molecules.
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China. xinghb@zju.edu.cn.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Jin
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Yang
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zongbi
authors.initials: Z
authors.lastname: Bao
authors.forename: Qilong
authors.initials: Q
authors.lastname: Ren
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Yang
authors.forename: Huabin
authors.initials: H
authors.lastname: Xing
mesh_terms: D002784:Cholesterol / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*; D009930:Organic Chemicals; D012995:Solubility
chemical_list: D052578:Ionic Liquids; D009930:Organic Chemicals; D002784:Cholesterol