title: An Extensible Neuroimaging e-Repository for Clinical Trials of Paediatric Brain Tumours.
abstract: Novel imaging techniques are playing an increasing role in tumour characterisation, assessment and management. However, incorporating imaging data into clinical trials presents a number of challenges in terms of quality control, standardisation in data collection, interoperability of widely used archiving systems and extensibility of imaging software architectures. Additionally, currently available monolithic applications cannot fulfil the diverse and rapidly changing needs of the clinical imaging research community. This paper discusses the limitations of the current CCLG Remote Data Entry (RDE) system and introduces the prototype of an alternative modular system based on the Extensible Neuroimaging Archive Toolkit (XNAT). The modular nature of the presented prototype promotes incremental software evolution and allows for flexible system customisation to suit the needs of individual imaging centres.
authors.affiliation: Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK.
authors.forename: Ahmed E
authors.initials: AE
authors.lastname: Fetit
authors.affiliation: Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK.
authors.forename: Omar
authors.initials: O
authors.lastname: Khan
authors.affiliation: Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK.
authors.forename: Soroosh
authors.initials: S
authors.lastname: Afyouni
authors.affiliation: Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
authors.forename: Niloufar
authors.initials: N
authors.lastname: Zarinabad
authors.affiliation: Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
authors.forename: Jan
authors.initials: J
authors.lastname: Novak
authors.affiliation: Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Peet
authors.affiliation: Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK.
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Arvanitis
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D002986:Clinical Trials as Topic / Q000458:organization & administration*; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods*; D059906:Neuroimaging / Q000379:methods*; D012985:Software Design; D018511:Systems Integration; D014584:User-Computer Interface