title: An ethane-bridged porphyrin dimer as a model of di-heme proteins: inorganic and bioinorganic perspectives and consequences of heme-heme interactions.
abstract: Interaction between heme centers has been cleverly implemented by Nature in order to regulate different properties of multiheme cytochromes, thereby allowing them to perform a wide variety of functions. Our broad interest lies in unmasking the roles played by heme-heme interactions in modulating different properties viz., metal spin state, redox potential etc., of the individual heme centers using an ethane-bridged porphyrin dimer as a synthetic model of dihemes. The large differences in the structure and properties of the diheme complexes, as compared to the monoheme analogs, provide unequivocal evidence of the role played by heme-heme interactions in the dihemes. This Perspective provides a brief account of our recent efforts to explore these interesting aspects and the subsequent outcomes.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India. sprath@iitk.ac.in.
authors.forename: Debangsu
authors.initials: D
authors.lastname: Sil
authors.forename: Sankar Prasad
authors.initials: SP
authors.lastname: Rath
mesh_terms: D003580:Cytochromes / Q000737:chemistry; D045263:Cytochromes a1 / Q000737:chemistry / Q000378:metabolism; D003575:Cytochromes c1 / Q000737:chemistry / Q000378:metabolism; D019281:Dimerization; D055664:Electrochemical Techniques; D004578:Electron Spin Resonance Spectroscopy; D004980:Ethane / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D005296:Ferrous Compounds / Q000737:chemistry; D006418:Heme / Q000737:chemistry*; D008968:Molecular Conformation; D009565:Nitrate Reductases / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D003580:Cytochromes; D005290:Ferric Compounds; D005296:Ferrous Compounds; D011166:Porphyrins; D006418:Heme; D045263:Cytochromes a1; D003575:Cytochromes c1; D009565:Nitrate Reductases; C054690:nitrate reductase (cytochrome); D004980:Ethane