title: Dyslipidemia in young patients with type 1 diabetes mellitus.
abstract: OBJECTIVE
  The association between type 1 diabetes mellitus (T1D) and dyslipidemia (DLP) increases the risk of cardiovascular disease (CVD). The aim of this study was to evaluate the presence of dyslipidemia in young T1D patients.
  
  
  METHODS
  The study design was cross-sectional and descriptive. We reviewed medical records of T1D patients followed at an endocrinology service, from 1998-2012.
  
  
  METHODS
  gender, actual age and age at diagnosis, duration of T1D since diagnosis, body mass index (BMI), pubertal stage, glycemic control (GC) determined by glycated hemoglobin (HbA1c), total cholesterol (TC), HDL, LDL, triglycerides (TG). To analyze lipid profile and metabolic control, we used the Brazilian Society of Diabetes Guidelines.
  
  
  RESULTS
  Were included 239 T1D patients, 136 (56.9%) females; mean ± SD: actual age 15.7 ± 5.0 years and at T1D diagnosis 7.3 ± 3.9; T1D duration 10.6 ± 6.4 years, 86.6% puberty, 15.1% overweight. The prevalence of DLP was 72.5%, 63.3% females, 86.6% puberty, mean ± SD: actual age 15.4 ± 4.8 years and at T1D diagnosis 7.2 ± 4.1 years, duration of T1D 10.7 ± 6.1 years. We found high-CT in 56.7%, low-HDL = 21.7%, high LDL = 44.0%, high-TG = 11.8%. Between females with DLP, 83.5% was in puberty. We find correlation between the presence of DLP, a poor GC and BMC.
  
  
  CONCLUSIONS
  We found a high prevalence of DLP in young patients with T1D, particularly in puberty females. Programs targeting the prevention of dyslipidemia should be adopted, especially for this group, in order to prevent/delay chronic complications and cardiovascular disease.
authors.affiliation: Pediatric Endocrinology Unit, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
authors.forename: Thaís Kataoka
authors.initials: TK
authors.lastname: Homma
authors.affiliation: School of Medicine, Santa Casa São Paulo, São Paulo, SP, Brazil.
authors.forename: Camila Matsuura
authors.initials: CM
authors.lastname: Endo
authors.affiliation: School of Medicine, Santa Casa São Paulo, São Paulo, SP, Brazil.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Saruhashi
authors.affiliation: School of Medicine, Santa Casa São Paulo, São Paulo, SP, Brazil.
authors.forename: Ana Paula Ivata
authors.initials: AP
authors.lastname: Mori
authors.affiliation: Pediatrics Department, ISCMSP, São Paulo, SP, Brazil.
authors.forename: Renata Maria de
authors.initials: RM
authors.lastname: Noronha
authors.affiliation: Pediatric Endocrinology Unit, Pediatrics Department, ISCMSP.
authors.forename: Osmar
authors.initials: O
authors.lastname: Monte
authors.affiliation: Pediatric Endocrinology Unit, Pediatrics Department, ISCMSP.
authors.forename: Luis Eduardo Procópio
authors.initials: LE
authors.lastname: Calliari
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology*; D050171:Dyslipidemias / Q000150:complications / Q000453:epidemiology*; D004812:Epidemiologic Methods; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D017678:Sex Distribution; D012737:Sex Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D002784:Cholesterol; D006442:Glycated Hemoglobin; D014280:Triglycerides