title: Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice.
abstract: The effects of dietary plant-origin glucosylceramide (GlcCer) on symptoms similar to those of inflammatory bowel diseasewere investigated in dextran sulfate sodium salt (DSS)-treated mice. Dietary GlcCer suppressed decreases in body weight due to DSS administration. To determine its effects on the colon, we examined its surface under a microscope following toluidine blue staining. Dietary GlcCer decreased DSS-induced chorionic crypt injury and elevated myeloperoxidase levels. Moreover, dietary GlcCer significantly suppressed the production of cytokines by the intestinal mucosa. These results provide evidence for the suppression of DSS-induced inflammation by dietary GlcCer.
authors.affiliation: Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine.
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Arai
authors.forename: Yu
authors.initials: Y
authors.lastname: Mizobuchi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Tokuji
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Aida
authors.forename: Shinji
authors.initials: S
authors.lastname: Yamashita
authors.forename: Masao
authors.initials: M
authors.lastname: Ohnishi
authors.forename: Mikio
authors.initials: M
authors.lastname: Kinoshita
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D016264:Dextran Sulfate / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D005963:Glucosylceramides / Q000008:administration & dosage* / Q000494:pharmacology; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D008807:Mice, Inbred BALB C; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D015431:Weight Loss / Q000187:drug effects
chemical_list: D016207:Cytokines; D005963:Glucosylceramides; D016264:Dextran Sulfate; D009195:Peroxidase