title: B-1 phagocytes: the myeloid face of B-1 cells.
abstract: The relationship between malignant B cells and macrophages has long been established. Furthermore, evolutionary studies have demonstrated that B cells from early vertebrates have both phagocytic and antibody production capabilities. In addition to their lymphoid nature, B-1 cells retain several myeloid characteristics. Various reports have demonstrated that B-1 cells can differentiate into phagocytes. However, descriptions of B-1 cells as a novel phagocyte cell member are rarely found in the literature. This review aims to present the available data regarding B-1 cell-derived phagocytes and also discusses how their existence might be relevant to hematopoiesis and immune responses.
authors.affiliation: Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Ana Flavia
authors.initials: AF
authors.lastname: Popi
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology*
keywords: B-1 cells; lymphoid; myeloid; phagocytosis