title: Different induction therapies for kidney transplantation with living donor.
abstract: BACKGROUND
  Indications for induction therapy is not consensual in living donors.
  
  
  OBJECTIVE
  The objective of this study was compare no induction with thymoglobulin and basiliximab induction in the incidence of acute rejection in kidney transplantation with living donor.
  
  
  METHODS
  We select all cases of renal transplantation with living donor performed in Hospital das Clínicas de Botucatu da UNESP during the period of January 2010 to December 2013. The group was divided by the type of medication used for induction.
  
  
  RESULTS
  A total of 90 patients were evaluated. There were no differences in baseline characteristics of age and underlying disease. The rate of biopsy-proven acute rejection was higher in the group without induction (42.9%) compared to basiliximab group (20%) and Thymoglobulin (16.7%), p = 0.04. The rejection by compatibility shows that the identical had the lower rejection rate (10%). The haploidentical group without induction had the highest rejection rates (53.3%). In all distinct group the rejection rates were similar with basiliximab or Thymoglobulin, p = NS. The use of induction therapy was associated independently with a lower risk of rejection (OR = 0.32 CI: 0.11 to 0.93, p = 0.036). There were no differences in renal function at 6 months and patient survival and graft in the three groups.
  
  
  CONCLUSIONS
  The haploidentical patients without induction were those with higher rates of acute rejection. The group of patients induced with Thymoglobulin had a higher immunological risk, however showed low rates of rejection.
  
  
  CONCLUSIONS
  The use of induction therapy resulted in lower rates of rejection in transplantation with living donor.
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Hong Si
authors.initials: HS
authors.lastname: Nga
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Paula Dalsoglio
authors.initials: PD
authors.lastname: Garcia
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Mariana Moraes
authors.initials: MM
authors.lastname: Contti
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Henrique Mochida
authors.initials: HM
authors.lastname: Takase
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Maria Fernanda Cordeiro
authors.initials: MF
authors.lastname: de Carvalho
authors.affiliation: Universidade Estadual Paulista, Brazil.
authors.forename: Luis Gustavo Modelli
authors.initials: LG
authors.lastname: de Andrade
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D000077552:Basiliximab; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use*; D012189:Retrospective Studies
chemical_list: D000911:Antibodies, Monoclonal; D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D011993:Recombinant Fusion Proteins; D000077552:Basiliximab; C512542:thymoglobulin