title: Green Synthesis of Oxovanadium(IV)/chitosan Nanocomposites and Its Ameliorative Effect on Hyperglycemia, Insulin Resistance, and Oxidative Stress.
abstract: In this paper, the preparation, characterization, and ameliorative effect on high-fat high-sucrose diet-induced hyperglycemia, insulin resistance, oxidative stress in mice of novel oxovanadium(IV)/chitosan (OV/CS) nanocomposites were investigated. The nanobiocomposite was produced by chemical reduction by chitosan and L-ascorbic acid using microwave heating, under environment-friendly conditions, using aqueous solutions, and notably, by using both mediators as reducing and stabilizing agents. In addition, OV/CS nanocomposites were characterized by transmission electron microscopy, energy dispersive spectroscopy, particle size, and zeta potential measurements. In vivo experiments were designed to examine whether the OV/CS nanocomposites would provide additional benefits on oxidative stress, hyperglycemia, and insulin resistance in mice with type 2 diabetes. The results rendered insulin resistant by treating with OV/CS nanocomposites alleviate insulin resistance and improve oxidative stress. Such nanocomposite seem to be a valuable therapy to achieve and/or maintain glycemic control and therapeutic agents in the treatment arsenal for insulin resistance and type 2 diabetes.
authors.affiliation: College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China. fs-lauyang@hotmail.com.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China. xujie9@ouc.edu.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Jie
authors.affiliation: College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China. foodgyl@outlook.com.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Guo
authors.affiliation: College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China. 1209539022@qq.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China. jfwang@ouc.edu.cn.
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China. xuechanghuouc@163.com.
authors.forename: Changhu
authors.initials: C
authors.lastname: Xue
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D004355:Drug Stability; D005951:Glucose Tolerance Test; D055772:Green Chemistry Technology; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008810:Mice, Inbred C57BL; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D018384:Oxidative Stress / Q000187:drug effects*; D014638:Vanadates / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: C075743:oxovanadium IV; D014638:Vanadates; D048271:Chitosan
keywords: Chitosan; Hyperglycemia; Insulin resistance; Oxidative stress; Oxovanadium(IV)/chitosan nanocomposites