title: Declined plasma sfrp5 concentration in patients with type 2 diabetes and latent autoimmune diabetes in adults.
abstract: OBJECTIVE
  Secreted frizzled-related protein 5 (sfrp5), like adiponectin, has been identified as a novel insulin-sensitising and anti-inflammatory adipokine. Our objective was to determine whether differences of circulating plasma sfrp5 concentration exist among type 2 diabetes (T2D), latent autoimmune diabetes in adults (LADA) and healthy population.
  
  
  METHODS
  Enzyme-linked immuno sorbent assay was employed to detect the circulating sfrp5 level in plasma, and other lab tests such as fasting glucose and creatinine were also examined. Correlation analysis between sfrp5 and characteristics of subjects was conducted IBM SPSS Statistics and GraphPad Prism.
  
  
  RESULTS
  Circulating sfrp5 level was significantly decreased in T2D and LADA patients plasma compared with that in healthy control (14.14±11.91ng/mL, 14.82±11.27ng/mL, 22.98±12.36ng/mL, respectively), although no differences was observed between LADA and T2D groups. Furthermore, we found sfrp5 was correlated with homeostasis model assessment of insulin resistance (HOMA-IR), diabetes duration and BMI. Finally we found sfrp5 was still negatively correlated with HOMA-IR after being adjusted for disease duration and BMI(r= -0.315, P< 0.05).
  
  
  CONCLUSIONS
  Our results support a role for SFRP5 as a protective factor in the pathogenesis of autoimmune diabetes and facilitate a novel aspect for diabetes research.
authors.affiliation: Liqing Cheng, Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, China, 400038.
authors.forename: Liqing
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Dongmei Zhang, Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China, 400038.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Bing Chen, Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, China, 400038.
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
keywords: Diabetes; Inflammation; Insulin resistance; Secreted frizzled-related protein 5