title: The Protective Effects of the VEGF -2578C>A and -1154G>A Polymorphisms Against Hypertension Susceptibility.
abstract: OBJECTIVE
  It has been reported that plasma vascular endothelial growth factor (VEGF) levels are elevated in hypertensive patients. The aim of this study was to investigate the association of -2578C>A and -1154G>A polymorphisms in the VEGF gene with susceptibility to hypertension.
  
  
  METHODS
  A total of 640 subjects (320 hypertensive patients and 320 healthy normotensive subjects) were enrolled in the study. Genotyping of the -2578C>A and -1154G>A polymorphisms was performed by polymerase chain reaction and restriction fragment length polymorphism analysis.
  
  
  RESULTS
  The CA and AA genotypes and dominant and recessive models of the -2578C>A polymorphism were protective against MetS susceptibility (p<0.0001, p=0.001, p<0.0001, and p=0.015, respectively). The GA genotype and dominant model (GG vs. GA+AA) of the -1154G >A polymorphism were found less frequently in patients with hypertension compared to the controls (p=0.0001, p<0.0001, respectively). Haplotypes of the -2578C>A and -1154G>A polymorphisms were also different between the patients and controls.
  
  
  CONCLUSIONS
  The A allele of the -2578C>A polymorphism and haplotypes of the -2578C>A and -1154G>A polymorphisms in the promoter region of the VEGF gene might be protective against the development of hypertension in Koreans. Further studies examining these associations in other populations are warranted.
authors.affiliation: 1 Department of Laboratory Medicine, School of Medicine, Jeju National University , Jeju, Republic of Korea.
authors.forename: Young Ree
authors.initials: YR
authors.lastname: Kim
authors.affiliation: 2 Department of Science Education, Teachers College, Jeju National University , Jeju, Republic of Korea.
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Hong
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A