title: [SECONDARY PREVENTION OF ARTERIAL HYPERTENSION IN VEHICLE DRIVERS--EFFICIENCY, SPECIFIC SAFETY].
abstract: OBJECTIVE
  To estimate effectiveness and safety of pharmacotherapy in vehicle drivers with arterial hypertension (AH).
  
  
  METHODS
  432 patients with grade I-III AH including 82 with cardiovascular complications largely of II and III grade were under observation during 2.5-4 months using clinical and instrumental methods (24hr AP & ECG monitoring) as well as psychophysiological testing (PPT).
  
  
  RESULTS
  Ramipril and atenolol were efficient in 77.4 and 91.6% of the cases respectively; side effects were documented in 23.9 and 10.9%, somnolence and apathy in 13%, signs of somnolence in 2.2% of the cases. PPT revealed deterioration of the ability to drive (p < 0.05) in the patients given rampiril and the absence of its change in those receiving atenolol. Teveten (eprosartan) and diroton (lisinopril) were efficient in 94.8 and 81% of the cases but 8.6% of the patients refused to continue therapy because of side effects, such as somnolence, dry cough. Diroton deteriorated results of PPT (p < 0.05) and teveten improved them (p < 0.01). The effectiveness of isradipine (lomir), clophiline, estulic and trandolapril was 93.7, 7-87.5, 5-81.2, 2-82%. Isradipine had beneficial effect on PPT results (p<O. 01). The remaining drugs negatively influenced the rapid response system (p < 0.05 < 0.01). Therapy with nebilet and teveten in combination with indap was effective in 83.3 and 93.3% of the cases and improved professional reliability of the drivers (p < 0.05, 0.01).
  
  
  CONCLUSIONS
  Assessment of efficacy and safety of pharmacotherapy in vehicle drivers must include evaluation of the degree and character of its influence on professional working ability. Beneficial effect of pharmacotherapy on the rapid response system with simultaneous normalization of AP and health status should be interpreted as evidence of specific safety and effectiveness of antihypertensive treatment.
authors.forename: A A
authors.initials: AA
authors.lastname: Elgarov
authors.forename: R M
authors.initials: RM
authors.lastname: Aramisova
authors.forename: M A
authors.initials: MA
authors.lastname: Elgarov
authors.forename: M A
authors.initials: MA
authors.lastname: Kalmykova
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001334:Automobile Driving; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000188:drug therapy*; D011597:Psychomotor Performance / Q000187:drug effects*; D055502:Secondary Prevention / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents