title: Could nanovesicles containing a penetration enhancer clinically improve the therapeutic outcome in skin fungal diseases?
abstract: OBJECTIVE
  To study whether the formulation of an antifungal drug in nanovesicular form containing skin penetration enhancer would clinically modulate its therapeutic effectiveness.
  
  
  METHODS
  Nanovesicles containing different skin penetration enhancers 'PEVs' were prepared and loaded with sertaconazole. Penetration-enhancer vesicles were characterized for entrapment efficiency, particle size, zeta potential, elasticity, viscosity, morphology and ex vivo skin deposition. Selected formulae were preliminary tested for clinical efficacy on patients suffering from tinea corporis and tinea versicolor.
  
  
  CONCLUSIONS
  The nanosize of the vesicles, their content of penetration enhancer and their deformable nature are three cornerstones positively influencing the therapeutic outcome of topical antifungal therapy, and hence, can be considered a promising treatment modality for skin fungal diseases.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, October 6 University, Giza Governorate, Egypt.
authors.forename: Eman A
authors.initials: EA
authors.lastname: Bsieso
authors.affiliation: Department of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Monazamet El Wehda El Afrikia St., El Abbassia, Cairo, Egypt.
authors.forename: Maha
authors.initials: M
authors.lastname: Nasr
authors.affiliation: Department of Dermatology, STDs & Andrology, Faculty of Medicine, Al-Minya University, Al-Minya, Egypt.
authors.forename: Noha H
authors.initials: NH
authors.lastname: Moftah
authors.affiliation: Department of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Monazamet El Wehda El Afrikia St., El Abbassia, Cairo, Egypt.
authors.forename: Omaima A
authors.initials: OA
authors.lastname: Sammour
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, October 6 University, Giza Governorate, Egypt.
authors.forename: Nabaweya A
authors.initials: NA
authors.lastname: Abd El Gawad
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002648:Child; D003881:Dermatomycoses / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D012867:Skin / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology*; D012869:Skin Absorption; D013876:Thiophenes / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D014783:Viscosity; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D053769:Nanocapsules; D014677:Pharmaceutical Vehicles; D013876:Thiophenes; C061131:sertaconazole
keywords: clinical perspective of efficacy; nanotechnology; penetration-enhancer vesicles; sertaconazole; tinea