title: Left ventricular hypertrophy on long-term cardiovascular outcomes in patients with ST-elevation myocardial infarction.
abstract: BACKGROUND
  Left ventricular hypertrophy (LVH) had been associated with increased adverse cardiovascular events in hypertensive patients. Prognostic significance of LVH in patients with ST-elevation myocardial infarction (STEMI) is not established. This study aimed to investigate prognostic impact of LVH on the patients with STEMI.
  
  
  METHODS
  We analyzed the data and clinical outcomes of 30-day survivors with STEMI who underwent successful coronary intervention from 2003 to 2009. Definition of LVH was LV mass index (LVMI) >115 g/m(2) in male and >95 g/m(2) in female. Patients were classified into a LVH group and a non-LVH group. Occurrence of major adverse cardiovascular events (MACE; death, recurrent MI, target vessel revascularization (TVR)) within 5 years was evaluated.
  
  
  RESULTS
  We enrolled 418 patients and mean follow-up duration was 43 ± 17 months. Two hundred and fourteen patients (51%) had LVH. The survival of the patients with LVH was significantly worse than the patients without LVH (log-rank p = 0.024). In a multivariate regression model, the presence of LVH was independently associated with increased risk for all-cause mortality (OR, 2.37; 95% CI, 1.096-5.123, p = 0.028). When the end points were analyzed based on LVH severity, all-cause mortality was significantly correlated with LVH severity (p = 0.011). The severe LVH was independently associated with increased risk for all-cause mortality (OR, 5.110; 95% CI, 1.454-17.9, p = 0.001).
  
  
  CONCLUSIONS
  LVH was associated with increased rate of adverse clinical outcomes in 30-day survivors after STEMI, who underwent successful coronary intervention.
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: Jin-Sun
authors.initials: JS
authors.lastname: Park
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: Jeong-Sook
authors.initials: JS
authors.lastname: Shin
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: You-Hong
authors.initials: YH
authors.lastname: Lee
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: Kyoung-Woo
authors.initials: KW
authors.lastname: Seo
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: Byoung-Joo
authors.initials: BJ
authors.lastname: Choi
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Choi
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: Myeong-Ho
authors.initials: MH
authors.lastname: Yoon
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: Gyo-Seung
authors.initials: GS
authors.lastname: Hwang
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: Seung-Jea
authors.initials: SJ
authors.lastname: Tahk
authors.affiliation: a Department of Cardiology , Ajou University School of Medicine , Suwon , Korea.
authors.forename: Joon-Han
authors.initials: JH
authors.lastname: Shin
mesh_terms: D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Left ventricular hypertrophy; myocardial infarction; prognosis