title: N-heterocyclic carbene metal complexes as bio-organometallic antimicrobial and anticancer drugs.
abstract: Late transition metal complexes that bear N-heterocyclic carbene (NHC) ligands have seen a speedy growth in their use as both, metal-based drug candidates and potentially active homogeneous catalysts in a plethora of C-C and C-N bond forming reactions. This review article focuses on the recent developments and advances in preparation and characterization of NHC-metal complexes (metal: silver, gold, copper, palladium, nickel and ruthenium) and their biomedical applications. Their design, syntheses and characterization have been reviewed and correlated to their antimicrobial and anticancer efficacies. All these initial discoveries help validate the great potential of NHC-metal derivatives as a class of effective antimicrobial and anticancer agents.
authors.affiliation: Centre for Nano & Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, Karnataka, India.
authors.forename: Siddappa A
authors.initials: SA
authors.lastname: Patil
authors.affiliation: Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine & Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
authors.forename: Shivaputra A
authors.initials: SA
authors.lastname: Patil
authors.affiliation: Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine & Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
authors.forename: Renukadevi
authors.initials: R
authors.lastname: Patil
authors.affiliation: Centre for Nano & Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, Karnataka, India.
authors.forename: Rangappa S
authors.initials: RS
authors.lastname: Keri
authors.affiliation: Centre for Nano & Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, Karnataka, India.
authors.forename: Srinivasa
authors.initials: S
authors.lastname: Budagumpi
authors.affiliation: Centre for Nano & Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, Karnataka, India.
authors.forename: Geetha R
authors.initials: GR
authors.lastname: Balakrishna
authors.affiliation: School of Chemistry & Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Tacke
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008670:Metals / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D006571:Heterocyclic Compounds; D008670:Metals; C030011:carbene; D008697:Methane
keywords: N-heterocyclic carbene; anticancer drug; antimicrobial; gold; palladium; silver