title: 5'- vs. 3'-end sugar conformational control in shaping up dinucleotides.
abstract: The 5'-end N-sugar puckering is currently believed to govern the intramolecular dinucleotide stacking. We demonstrate that if this 5'-conformation is indeed important in shaping up dinucleotide structures, the 3'-end sugar conformation can either potentiate or cancel the stacking capacity induced by the 5'-end N-sugar conformation.
authors.affiliation: Université de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, UFR de Pharmacie, 51 rue Cognacq-Jay, F-51096 Reims Cedex, France. pascale.clivio@univ-reims.fr.
authors.forename: J
authors.initials: J
authors.lastname: Jakhlal
authors.forename: S
authors.initials: S
authors.lastname: Coantic-Castex
authors.forename: C
authors.initials: C
authors.lastname: Denhez
authors.forename: C
authors.initials: C
authors.lastname: Petermann
authors.forename: A
authors.initials: A
authors.lastname: Martinez
authors.forename: D
authors.initials: D
authors.lastname: Harakat
authors.forename: D
authors.initials: D
authors.lastname: Guillaume
authors.forename: P
authors.initials: P
authors.lastname: Clivio
mesh_terms: D002236:Carbohydrate Conformation; D002942:Circular Dichroism; D015226:Dinucleoside Phosphates / Q000737:chemistry*
chemical_list: D015226:Dinucleoside Phosphates; C017758:thymidylyl-(3'-5')-thymidine