title: Technical aspects and effectiveness of percutaneous fetal therapies for large sacrococcygeal teratomas: cohort study and literature review.
abstract: OBJECTIVE
  The objectives of this study were to evaluate the efficacy of minimally invasive ablation of high-risk large sacrococcygeal teratomas (SCT) and to compare the efficacy of vascular and interstitial tumor ablation.
  
  
  METHODS
  This was a retrospective multicenter study including a cohort of fetuses with high-risk large SCTs between 2004 and 2010. In addition, we performed a systematic literature review of all cases that underwent tumor ablation in order to compare the survival rates after 'vascular' and 'interstitial' ablation. Statistical analysis was conducted using Bayesian methods.
  
  
  RESULTS
  In our cohort, a total of 13 fetuses had high-risk large SCT and five of them underwent tumor ablation. The estimated difference in hydrops resolution rate between the fetal intervention and the no fetal intervention groups was 44.6% (95% credibility interval, 1.5 to 81.0%; Pdiff> 0 = 97.9%). The estimated difference in survival rate between the fetal intervention and the no fetal intervention groups was 31.0% (13.9 to 48.1%; Pdiff> 0 = 99.9%). We analyzed our five cases together with 28 cases from the literature and estimated the difference in survival rate between the vascular and interstitial ablation groups as 19.8% (-13.1 to 50.1%; Pdiff> 0 = 88.3%). The estimated difference in hydrops resolution rate between the vascular and the interstitial ablation groups was 36.7% (-5.7 to 72.7%; Pdiff> 0 = 95.5%).
  
  
  CONCLUSIONS
  Minimally invasive surgery seems to improve perinatal outcome in cases of high-risk large fetal SCT. Our findings suggest that 'vascular' ablation may improve outcome and may be more effective than 'interstitial' tumor ablation, but this hypothesis needs further investigation in a larger multicenter prospective study. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.
authors.affiliation: Texas Children's Fetal Center and Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.|Department of Obstetrics and Gynecology, Strasbourg University Hospital, Strasbourg, France.|INSERM, UMR-S 1121, 'Biomatériaux et Bioingénierie', Strasbourg, France.
authors.forename: N
authors.initials: N
authors.lastname: Sananes
authors.affiliation: Texas Children's Fetal Center and Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: P
authors.initials: P
authors.lastname: Javadian
authors.affiliation: Texas Children's Fetal Center and Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: I
authors.initials: I
authors.lastname: Schwach Werneck Britto
authors.affiliation: Department of Public Health, Strasbourg University Hospital, Strasbourg, France.
authors.forename: N
authors.initials: N
authors.lastname: Meyer
authors.affiliation: Department of Obstetrics and Gynecology, Strasbourg University Hospital, Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Koch
authors.affiliation: Department of Obstetrics and Gynecology, Strasbourg University Hospital, Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Gaudineau
authors.affiliation: Department of Obstetrics and Gynecology, Strasbourg University Hospital, Strasbourg, France.
authors.forename: R
authors.initials: R
authors.lastname: Favre
authors.affiliation: Texas Children's Fetal Center and Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.|Department of Obstetrics and Gynecology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Ruano
mesh_terms: D055011:Ablation Techniques / Q000379:methods* / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D046128:Fetal Therapies / Q000379:methods*; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D011247:Pregnancy; D012189:Retrospective Studies; D012445:Sacrococcygeal Region; D013125:Spinal Neoplasms / Q000601:surgery*; D016019:Survival Analysis; D013724:Teratoma / Q000601:surgery*; D016896:Treatment Outcome
keywords: fetal surgery; sacrococcygeal teratoma; tumor interstitial ablation; vascular ablation