title: Determination of association constant of host-guest supramolecular complex (molecular recognition of carbamazepine, antiseizure drug, with calix(4)arene).
abstract: The thermodynamic property of the host-guest, inclusion complex formed between p-t-butyl calix(4)arene which is a supramolecule, and the antiseizure drug, carbamazepine was studied. p-t-Butyl calix(4)arene has been used as a host molecule and carbamazepine as a guest molecule. Optical absorption spectral studies were carried out to investigate the molecular recognition properties of p-t-butyl calix(4)arene with carbamazepine. The stochiometry of the host-guest complexes formed and the association constant were determined. An interesting 1:2 stochiometric host-guest complex was formed. Job's continuous method of variation and Benesi-Hildebrand expression were used for the determination of binding constant and the stochiometry of the host-guest complex formed. Molecular dimension of the host molecule plays a vital role in the formation of the host-guest stochiometric complexes.
authors.affiliation: Department of Chemistry, Shri Meenakshi Government College for Women (Autonomous), Madurai 625 002, India. Electronic address: jayabal@outlook.com.
authors.forename: C
authors.initials: C
authors.lastname: Meenakshi
authors.affiliation: Department of Physical Sciences, Bannari Amman Institute of Technology, Sathyamangalam, Erode 638 401, India.
authors.forename: P
authors.initials: P
authors.lastname: Jayabal
authors.affiliation: Department of Laser Studies, School of Physics, Madurai Kamaraj University, Madurai 625 021, India. Electronic address: vr.optics1@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Ramakrishnan
mesh_terms: D000927:Anticonvulsants / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry* / Q000378:metabolism; D002220:Carbamazepine / Q000737:chemistry* / Q000378:metabolism; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
chemical_list: D000927:Anticonvulsants; D010636:Phenols; C121325:calix(4)arene; C525100:para-tert-butylcalix(4)arene; D047250:Calixarenes; D002220:Carbamazepine
keywords: Antiseizure drug; Association constant; Carbamazepine; Molecular recognition; p-t-Butyl calix(4)arene