title: Colony-stimulating factors for chemotherapy-related febrile neutropenia are associated with improved prognosis in adult acute lymphoblastic leukemia.
abstract: Colony-stimulating factors (CSF) have been widely used to prevent febrile neutropenia associated with chemotherapy. Due to the high intensity of chemotherapy in acute lymphoblastic leukemia (ALL), CSF as a crucial component of supportive care has played a significant role in the therapy. However, the effectiveness of CSF in treatment has not been identified by large clinical trials until now. The aim of the present study was to evaluate the effect of CSF on the long-term outcome of adult ALL patients. A comprehensive search strategy has been conducted, which covered the Cochrane Central Register of Controlled Trials, PubMed and Web of Science. The result includes seven randomized controlled trials containing a total of 753 patients. The administration of CSF significantly reduced the mortality at the end of the follow-up (RR, 0.85; 95% CI, 0.75-0.95), the mortality at day 30 (RR, 0.41; 95% CI, 0.23-0.74) and the number of patients with infection or severe infections (RR, 0.8; 95% CI, 0.7-0.9 and RR, 0.48; 95% CI, 0.3-0.75). The addition of CSF also marginally increased the number of patients achieving CR (RR, 1.14; 95% CI, 1.05-1.23). The use of CSF also shortened the duration of neutropenia (median days, 8-17 to 12.5-24). In conclusion, CSFs can be administered to ALL patients during myelosuppressive chemotherapy, particularly in the induction phase.
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Shi-Guang
authors.initials: SG
authors.lastname: Ye
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Y I
authors.initials: YI
authors.lastname: Ding
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Ai-Bin
authors.initials: AB
authors.lastname: Liang
keywords: acute lymphoblastic leukemia; colony-stimulating factors; meta-analysis; survival