title: QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode.
abstract: The present study aimed to explore the holistic mechanism for the antihypertrophic effect of a compound in Chinese medicine, QiShenYiQi Pills (QSYQ) and the contributions of its components to the effect in rats with cardiac hypertrophy (CH). After induction of CH by ascending aortic stenosis, rats were treated with QSYQ, each identified active ingredient (astragaloside IV, 3, 4-dihydroxy-phenyl lactic acid or notoginsenoside R1) from its 3 major herb components or dalbergia odorifera, either alone or combinations, for 1 month. QSYQ markedly attenuated CH, as evidenced by echocardiography, morphology and biochemistry. Proteomic analysis and western blot showed that the majority of differentially expressed proteins in the heart of QSYQ-treated rats were associated with energy metabolism or oxidative stress. Each ingredient alone or their combinations exhibited similar effects as QSYQ but to a lesser extent and differently with astragaloside IV and notoginsenoside R1 being more effective for enhancing energy metabolism, 3, 4-dihydroxy-phenyl lactic acid more effective for counteracting oxidative stress while dalbergia odorifera having little effect on the variables evaluated. In conclusion, QSYQ exerts a more potent antihypertrophic effect than any of its ingredients or their combinations, due to the interaction of its active components through a multi-component and multi-target mode.
authors.affiliation: 1] Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China [2] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [3] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [4] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Chen
authors.affiliation: 1] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [2] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [3] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Li
authors.affiliation: 1] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [2] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [3] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Chun-Shui
authors.initials: CS
authors.lastname: Pan
authors.affiliation: 1] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [2] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [3] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.affiliation: 1] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [2] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [3] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Fan
authors.affiliation: 1] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [2] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [3] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Ke
authors.initials: K
authors.lastname: He
authors.affiliation: 1] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [2] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [3] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: 1] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [2] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [3] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Liu
authors.affiliation: 1] Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China [2] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [3] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [4] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Qing-Fang
authors.initials: QF
authors.lastname: Chen
authors.affiliation: Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptide, Ministry of Health, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bai
authors.affiliation: 1] Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China [2] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [3] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [4] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Chuan-She
authors.initials: CS
authors.lastname: Wang
authors.affiliation: The School of Chinese Medicine of Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
authors.forename: Bing
authors.initials: B
authors.lastname: He
authors.affiliation: The School of Chinese Medicine of Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
authors.forename: Ai-Ping
authors.initials: AP
authors.lastname: Lv
authors.affiliation: 1] Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China [2] Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China [3] Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing, China [4] Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of China, Beijing, China.
authors.forename: Jing-Yan
authors.initials: JY
authors.lastname: Han
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000188:drug therapy* / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004734:Energy Metabolism / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D036145:Ginsenosides / Q000008:administration & dosage; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D011312:Pressure; D040901:Proteomics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000008:administration & dosage; D014315:Triterpenes / Q000008:administration & dosage
chemical_list: D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D012503:Saponins; D014315:Triterpenes; C052064:astragaloside A; C072936:notoginsenoside R1