title: Serum cytokines and anxiety in adolescent depression patients: Gender effect.
abstract: The present study compares the serum cytokine levels between adolescent depression patients and healthy controls and assesses correlation between depression, anxiety scores and serum levels of eight cytokines. Study also checked the variation in serum levels with medication status (medication free/naïve vs. patients on medication). Following clinical and psychometric assessment of 77 adolescent (aged 13-18 years) depression patients (49 males and 28 females; 56 medication free/naïve) and 54 healthy controls (25 males, 29 females), eight cytokines (IL-1β, IL-2, IL-6, IL-10, TNF-α, IFN-γ, TGF-β1 and IL-17A {denoted IL-17 throughout}) were measured in serum using ELISA. Depressed adolescents had significantly high levels of IL-2 (p<0.001) and IL-6 (p=0.03) as compared to controls. The female population skewed the result of one cytokine (IL-6) in patients. Anxiety scores showed positive correlation (only in female patients) with IL-1β, IL-10 and negative correlation with TGF-β1 and IL-17. The gender effect in relationship between anxiety and cytokines was not straightforward. On comparing study groups on the medication/naïve status, IL-2 and TGF-β1 showed significant difference between the groups (p<0.001, p=0.007 higher in medicated). Depression in adolescents was associated with elevation of proinflammatory serum cytokines with a gender bias for females. Anxiety scores correlated negatively with TGF-β1 and IL-17.
authors.affiliation: Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Pallavi
authors.affiliation: Department of Psychiatry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Sagar
authors.affiliation: Department of Psychiatry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Manju
authors.initials: M
authors.lastname: Mehta
authors.affiliation: Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Subhadra
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Arulselvi
authors.initials: A
authors.lastname: Subramanium
authors.affiliation: Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Farah
authors.initials: F
authors.lastname: Shamshi
authors.affiliation: Stanley Browne Research Laboratory, The Leprosy Mission, New Delhi 110093, India.
authors.forename: Utpal
authors.initials: U
authors.lastname: Sengupta
authors.affiliation: Department of Biostatistics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Ravindra M
authors.initials: RM
authors.lastname: Pandey
authors.affiliation: Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. Electronic address: mukhoak1953@gmail.com.
authors.forename: Asok K
authors.initials: AK
authors.lastname: Mukhopadhyay
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000097:blood* / Q000209:etiology; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000097:blood* / Q000150:complications; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007378:Interleukins / Q000097:blood; D008297:Male; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha
keywords: Adolescent depression; Correlation; Cytokines; Gender-difference