title: Lycopene has reduced renal damage histopathologically and biochemically in experimental renal ischemia-reperfusion injury.
abstract: BACKGROUND
  The present study aimed to investigate whether the inflammatory and antioxidant lycopene has a therapeutic effect against renal ischemia/reperfusion (I/R) injury.
  
  
  METHODS
  In this study, 24 Wistar-Albino rats, weighing from 200 to 250 g, were divided into four groups. All rats underwent median laparotomy under anesthesia. No procedures were performed in the control group (Group C), whereas 100 mg/kg lycopene was administered by gavage in the lycopene group (Group L). The arteries of both kidneys were clamped for 45 min in the ischemia group (Group I), whereas 100 mg/kg lycopene was administered by gavage 30 min before clamping renal arteries, and ischemia was performed in the treatment group (Group T) rats. For all rats, blood samples and renal tissues were collected at 6 h of reperfusion. Samples were used to examine serum BUN, creatinine, MDA and GSH levels, and the renal tissues were used to examine MDA and GSH levels, and renal histopathologies.
  
  
  RESULTS
  The treatment group had statistically significant lower serum MDA levels, histopathological tubular vacuolization, loss of brush border and tubular dilatation (p < 0.05), whereas serum BUN, creatinine, tissue MDA, and tissue and serum GSH levels were improved in favor of the treatment group, even though it was not statistically significant (p > 0.05).
  
  
  CONCLUSIONS
  The present study demonstrated that lycopene, which was administered prior to renal I/R injury, prevented renal damage through biochemical and histopathological parameters.
authors.affiliation: a Department of Pediatric Surgery .
authors.forename: Cem
authors.initials: C
authors.lastname: Kaya
authors.affiliation: a Department of Pediatric Surgery .
authors.forename: Ramazan
authors.initials: R
authors.lastname: Karabulut
authors.affiliation: a Department of Pediatric Surgery .
authors.forename: Zafer
authors.initials: Z
authors.lastname: Turkyilmaz
authors.affiliation: a Department of Pediatric Surgery .
authors.forename: Kaan
authors.initials: K
authors.lastname: Sonmez
authors.affiliation: b Department of Pathology , and.
authors.forename: Gamze
authors.initials: G
authors.lastname: Kulduk
authors.affiliation: c Department of Biochemistry , Faculty of Medicine, Gazi University , Ankara , Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Gülbahar
authors.affiliation: a Department of Pediatric Surgery .
authors.forename: Faik
authors.initials: F
authors.lastname: Köse
authors.affiliation: a Department of Pediatric Surgery .
authors.forename: Abdullah Can
authors.initials: AC
authors.lastname: Basaklar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001806:Blood Urea Nitrogen; D002338:Carotenoids / Q000008:administration & dosage*; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D005978:Glutathione / Q000097:blood; D007684:Kidney Tubules / Q000473:pathology*; D000077276:Lycopene; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D000975:Antioxidants; D002338:Carotenoids; D008315:Malondialdehyde; D003404:Creatinine; D005978:Glutathione; D000077276:Lycopene
keywords: Free radical; lycopene; renal ischemia/reperfusion injury