title: Affinity-mediated capture and release of amphiphilic copolymers for controlling antimicrobial activity.
abstract: Capture and release of amphiphilic copolymers by a nano-sized polysaccharide gel (nanogel) was controlled by altering the hydrophobic binding affinity between the copolymer chains and nanogel. The antimicrobial activity of captured copolymer chains was suppressed, and regained upon release from the nanogel.
authors.affiliation: Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA. kkuroda@umich.edu.
authors.forename: Haruko
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kazunari
authors.initials: K
authors.lastname: Akiyoshi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kuroda
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002784:Cholesterol / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D000080385:Nanogels; D011108:Polymers; D011134:Polysaccharides; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D002784:Cholesterol