title: Investigation of Friction-induced Damage to the Pig Cornea.
abstract: Mechanical friction causes damage to the cornea. A friction measurement device with minimal intervention with the pig cornea tear film revealed a low friction coefficient of 0.011 in glycerine solution. Glycerine molecules presumably bind to water, mucins, and epithelial cells and therewith improve both squeeze film and boundary lubrication. Using confocal microscopy, we determined that glycerine solution reduced damage to epithelial cells by 50% compared with the phosphate buffer saline.
authors.affiliation: University Medical Center Groningen and University of Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, Groningen, The Netherlands.
authors.forename: Raquel C
authors.initials: RC
authors.lastname: Barros
authors.affiliation: University Medical Center Groningen and University of Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, Groningen, The Netherlands.
authors.forename: Theo G
authors.initials: TG
authors.lastname: Van Kooten
authors.affiliation: University Medical Center Groningen and University of Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, Groningen, The Netherlands; Ducom Instruments Europe B.V, Center for Innovation, Groningen, The Netherlands. Electronic address: deepak.v@ducom.com.
authors.forename: Deepak Halenahally
authors.initials: DH
authors.lastname: Veeregowda
mesh_terms: D000818:Animals; D003315:Cornea / Q000473:pathology*; D065306:Corneal Injuries / Q000473:pathology*; D004195:Disease Models, Animal; D018613:Microscopy, Confocal / Q000379:methods*; D013314:Stress, Mechanical; D013552:Swine
keywords: confocal microscopy; cornea; friction device; glycerine