title: A topical desiccant agent in association with ultrasonic debridement in the initial treatment of chronic periodontitis: a clinical and microbiological study.
abstract: Effective sub-gingival debridement is crucial to prevent serious systemic infections in hospitalized patients. Lack of compliance and the impracticality of repeated treatment in a short span of time are identified barriers to the performance of full mouth scaling and root planing (SRP). The aim of this randomized study was to evaluate the clinical and microbiological effects of the adjunctive administration of a locally delivered desiccant liquid with molecular hygroscopic properties (HYBENX® Oral Tissue Decontaminant™; HBX) in association with sub-gingival ultrasonic debridement (UD) in a hospital setting. Sixteen patients presenting moderate to severe chronic periodontitis were followed in a randomized 3 month, split mouth, single-blind, prospective study. At baseline (T1) control and test sides were treated with supra and subgingival UD with or without the association of a locally delivered desiccant liquid (HBX). Treatment was repeated after 6 weeks (T2). Clinical and microbiological parameters were assessed at T1, T2 and at 3 months (T3). The test group sites presented a significantly greater reduction in visible plaque index (VPI), bleeding on probing scores (BOP) and gingival index (GI) at T2 and T3 compared to the control group sites. HBX as monotherapy reached the same bacterial load reduction as UD. Compared to UD, a combined HBX-UD treatment resulted in a statistically significant greater bacterial load reduction immediately after treatment. A significantly lower anaerobic bacterial load was still present at T2. Data obtained show that decreased inflammatory signs and reduction of the bacterial load can be obtained in the short term by topical association of the desiccant agent HBX with UD.
authors.affiliation: Department of Surgery, School of Dentistry, University of Verona, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Lombardo
authors.affiliation: Department of Pathology and Diagnostic, University of Verona, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Signoretto
authors.affiliation: Department of Surgery, School of Dentistry, University of Verona, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Corrocher
authors.affiliation: Department of Surgery, School of Dentistry, University of Verona, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Pardo
authors.affiliation: Department of Surgery, School of Dentistry, University of Verona, Italy.
authors.forename: Jacopo
authors.initials: J
authors.lastname: Pighi
authors.affiliation: Department of Surgery, School of Dentistry, University of Verona, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Rovera
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Caccuri
authors.affiliation: Department of Surgery, School of Dentistry, University of Verona, Italy.
authors.forename: Pier Francesco
authors.initials: PF
authors.lastname: Nocini
mesh_terms: D000328:Adult; D000368:Aged; D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D055113:Chronic Periodontitis / Q000382:microbiology* / Q000601:surgery / Q000628:therapy*; D003646:Debridement; D005260:Female; D006801:Humans; D058427:Hygroscopic Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014464:Ultrasonic Therapy
chemical_list: D058427:Hygroscopic Agents
keywords: Anaerobic bacterial load; Disinfection; Periodontitis; Topical agent; Ultrasonic debridement