title: Oxidative Stress and Lung Ischemia-Reperfusion Injury.
abstract: Ischemia-reperfusion (IR) injury is directly related to the formation of reactive oxygen species (ROS), endothelial cell injury, increased vascular permeability, and the activation of neutrophils and platelets, cytokines, and the complement system. Several studies have confirmed the destructiveness of the toxic oxygen metabolites produced and their role in the pathophysiology of different processes, such as oxygen poisoning, inflammation, and ischemic injury. Due to the different degrees of tissue damage resulting from the process of ischemia and subsequent reperfusion, several studies in animal models have focused on the prevention of IR injury and methods of lung protection. Lung IR injury has clinical relevance in the setting of lung transplantation and cardiopulmonary bypass, for which the consequences of IR injury may be devastating in critically ill patients.
authors.affiliation: Thoracic Surgery Department, Laboratory of Airways and Lung, Hospital of Clínicas of Porto Alegre, Ramiro Barcelos 2.350, 90035-903 Porto Alegre, RS, Brazil ; Federal University of Rio Grande of Sul (FRGS), Rua Ramiro Barcelos 2400, 2° andar Bairro Santana, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: Renata Salatti
authors.initials: RS
authors.lastname: Ferrari
authors.affiliation: Thoracic Surgery Department, Laboratory of Airways and Lung, Hospital of Clínicas of Porto Alegre, Ramiro Barcelos 2.350, 90035-903 Porto Alegre, RS, Brazil ; Federal University of Rio Grande of Sul (FRGS), Rua Ramiro Barcelos 2400, 2° andar Bairro Santana, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: Cristiano Feijó
authors.initials: CF
authors.lastname: Andrade
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology*; D015222:Sodium Channels / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015220:Calcium Channels; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species; D015222:Sodium Channels