title: Maternal serum omentin-1 profile is similar in humans and in the rat animal model.
abstract: Omentin-1 is an adipocytokine with anti-inflammatory activity that has been associated with different metabolic disorders. The aim of this study is to investigate the serum profiles of omentin-1 throughout human and rat pregnancy. Serum omentin-1 levels were determined by ELISA in a prospective cohort study of healthy pregnant women (n=40) during the three trimesters of pregnancy and in twenty healthy non-pregnant women during the follicular and luteal phase of the menstrual cycle. In addition, serum omentin-1 levels were measured in rats during different periods of pregnancy (gestational days 8, 12, 16, 19, and 21) and in an age-matched control (virgin) group of rats (n=12rats/group). Finally, immunohistochemistry was used to demonstrate the presence of omentin-1 protein in human and rat placenta. Omentin-1 immunoreactivity was detected in cytotrophoblasts, syncytiotrophoblasts, sparse Hofbauer cells, and endothelial cells of the stem villi of human placenta. Additionally, it was detected in the labyrinthine trophoblast and yolk sac layer of the rat placenta. Human and rat serum omentin-1 levels were significantly lower in the late gestational period when compared with the non-pregnant women and virgin rats (p<0.05). Serum omentin-1 changes were not significant throughout the gestation in both species (p>0.05). Human serum omentin-1 levels have an inverse relationship with triglyceride levels during pregnancy. Our findings have not determined the exact role of omentin-1 during pregnancy, concerning the metabolic control of triglycerides and other energy sources. Whether omentin-1 decrease implies a regulatory function is still not clear. Further studies are needed to address this issue and determine the role of omentin-1 in metabolic adaptations during normal human and rat pregnancy.
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: María F
authors.initials: MF
authors.lastname: Garcés
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Ruíz-Linares
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Vallejo
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Jhon J
authors.initials: JJ
authors.lastname: Peralta
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sanchez
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Alexsandra
authors.initials: A
authors.lastname: Ortiz-Rovira
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Yurani
authors.initials: Y
authors.lastname: Curtidor
authors.affiliation: Department of Obstetrics & Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Mario O
authors.initials: MO
authors.lastname: Parra
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Luis G
authors.initials: LG
authors.lastname: Leal
authors.affiliation: Institute of Clinical Investigations, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Alzate
authors.affiliation: Deparment of Pathology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Bernarda Jineth
authors.initials: BJ
authors.lastname: Acosta
authors.affiliation: Department of Physiology (CIMUS), School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Diéguez
authors.affiliation: Department of Physiology (CIMUS), School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Nogueiras
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia. Electronic address: jecaminosp@unal.edu.co.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Caminos
mesh_terms: D000328:Adult; D000818:Animals; D002824:Chorionic Villi / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007150:Immunohistochemistry; D037102:Lectins / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism; D015017:Yolk Sac / Q000378:metabolism; D055815:Young Adult
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D014280:Triglycerides; C000591992:omentin protein, rat
keywords: Adipocytokines; Adiponectin; Gestation; Omentin-1