title: Vitamin E protects salivary glands dysfunction induced by ionizing radiation in rats.
abstract: The purpose of this study is to investigate the radioprotective effect of vitamin E as a natural product. Vitamin E protects the salivary glands dysfunction that is induced by ionizing radiation. It was analysed with radioisotope scintigraphy and then salivary gland to background counts ratio was calculated. Histopathological evaluation was performed. The rats were treated with vitamin E at dose of 400IU/kg 48, 24, and 1h before 15Gy gamma rays irradiation. The rats were evaluated for the salivary gland function through nuclear medicine protocol. Radiation causes significant salivary glands dysfunction at the 3rd and the 70th days with a reduction in radioactivity uptake in the salivary glands. Ratios of salivary gland to background radioactivities were 1.99±0.11, 1.58±0.08 and 1.92±0.04 for control, radiation, and vitamin E plus radiation groups, respectively. Vitamin E significantly improved salivary gland dysfunction induced by ionizing radiation in the rats. In conclusion, our results indicate protective effects of vitamin E against salivary gland dysfunction induced by gamma radiation. Thus, vitamin E is a promising radioprotective agent for patients who receive radiation in head and neck cancer therapy.
authors.affiliation: Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Abedi
authors.affiliation: Department of Oral Medicine, Faculty of Dentistry, Babol University of Medical Science, Babol, Iran; Cellular and Biology Research Center, Babol University of Medical Science, Babol, Iran. Electronic address: fateme.yarmand@gmail.com.
authors.forename: Fateme
authors.initials: F
authors.lastname: Yarmand
authors.affiliation: Department of Oral Medicine, Faculty of Dentistry, Babol University of Medical Science, Babol, Iran; Cellular and Biology Research Center, Babol University of Medical Science, Babol, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Motallebnejad
authors.affiliation: Dental Materials Research Center, Faculty of Dentistry, Babol University of Medical Science, Babol, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Seyedmajidi
authors.affiliation: Department of Radiotherapy, Faculty of Medicine, Babol University of Medical Science, Babol, Iran.
authors.forename: Dariush
authors.initials: D
authors.lastname: Moslemi
authors.affiliation: Department of Physiology and Cellular and Molecular Biology Research Center, Babol University of Medical Science, Babol, Iran.
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Ashrafpour
authors.affiliation: Faculty of Medicine, Babol University of Medical Science, Babol, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Bijani
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Babol University of Medical Science, Babol, Iran.
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Moghadamnia
authors.affiliation: Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mardanshahi
authors.affiliation: Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Seyed Jalal
authors.initials: SJ
authors.lastname: Hosseinimehr
mesh_terms: D000818:Animals; D008297:Male; D011839:Radiation, Ionizing; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000528:radiation effects*; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D011837:Radiation-Protective Agents; D014810:Vitamin E
keywords: Radioprotective; Radiotherapy; Salivary gland dysfunction; Vitamin E