title: [Advance in studies on effect of Glycyrrhizae Radix et Rhizoma in relieving purgative activity of Rhei Radix et Rhizoma].
abstract: Rhei Radix et Rhizoma, as a commonly used traditional Chinese medicine, has been widely applied in clinic. Its major purgative constituent is anthraquinones, which are believed to be a toxic ingredient. Glycyrrhizae Radix et Rhizoma has been reputed as the best alexipharmic to moderate medicine natures. In this paper, the effect of Glycyrrhizae Radix et Rhizoma in relieving purgative activity of Rhei Radix et Rhizoma was studied in two aspects--the boiling process and intestinal metabolism; Studies on combined administration of Glycyrrhizae Radix et Rhizoma and Rhei Radix et Rhizoma in recent years were summarized according to chemical constituent, intestinal flora, I/II phase metabolism and drug transport. However, the material basis and mechanism for their compatibility remain unclear, further studies will be made in the future.
authors.forename: Bin
authors.initials: B
authors.lastname: Su
authors.forename: Xiao-bo
authors.initials: XB
authors.lastname: Li
mesh_terms: D000818:Animals; D002400:Cathartics / Q000009:adverse effects / Q000032:analysis / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000032:analysis / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D006801:Humans; D012250:Rheum / Q000009:adverse effects* / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry*
chemical_list: D002400:Cathartics; D004365:Drugs, Chinese Herbal