title: Lysosome targeting fluorescence probe for imaging intracellular thiols.
abstract: A BODIPY-based fluorescence turn-on probe, exhibiting high selectivity and sensitivity towards intracellular thiols with excellent lysosomal localization is reported. The probe displayed fast response towards biothiols in aqueous solution. Localization of the probe in lysosome was demonstrated by intracellular colocalization studies with the aid of LysoSensor Green.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411008, India. ptalukdar@iiserpune.ac.in.
authors.forename: Dnyaneshwar
authors.initials: D
authors.lastname: Kand
authors.forename: Tanmoy
authors.initials: T
authors.lastname: Saha
authors.forename: Mayurika
authors.initials: M
authors.lastname: Lahiri
authors.forename: Pinaki
authors.initials: P
authors.lastname: Talukdar
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D021621:Imaging, Three-Dimensional; D042541:Intracellular Space / Q000737:chemistry*; D007700:Kinetics; D008247:Lysosomes / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds