title: Analysis of alternatives for insulinizing patients to achieve glycemic control and avoid accompanying risks of hypoglycemia.
abstract: The aims of the present study were to explore the efficacy of glycemic control and the risks of hypoglycemia with different methods of insulin therapy, and to provide reference data for the clinical treatment of diabetes. In this retrospective study, hospitalized patients diagnosed with type 2 diabetes between March and December 2014, in the Department of Endocrinology in the First Affiliated Hospital of Wannan Medical College, were divided into three groups, including an intensive insulin analogue therapy group, a premixed insulin analogue treatment group and a premixed human insulin therapy group. The efficacy of glycemic control and the incidence of hypoglycemia were determined in each of the insulin treatment groups. Compared with the other treatment groups, the intensive insulin analogue therapy group was associated with superior blood glucose control, shorter time to reach standard insulin regimen, shorter hospitalization time, fewer fluctuations in blood glucose levels and lower insulin dosage on discharge from hospital. However, this treatment was also associated with a high risk of hypoglycemia. In conclusion, when combined with the effective prevention of hypoglycemia and appropriate nursing care (especially in hospital care), intensive insulin analogue therapy may provide the greatest benefit to patients.
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China ; Anhui Province Key Laboratory of Biological Macro-molecules Research, Wannan Medical College, Wuhu, Anhui 241003, P.R. China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China ; Anhui Province Key Laboratory of Biological Macro-molecules Research, Wannan Medical College, Wuhu, Anhui 241003, P.R. China.
authors.forename: Qianyin
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Miao
authors.affiliation: Anhui Province Key Laboratory of Biological Macro-molecules Research, Wannan Medical College, Wuhu, Anhui 241003, P.R. China ; Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu, Anhui 241003, P.R. China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Libing
authors.initials: L
authors.lastname: Xia
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Meiqin
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Binhua
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Yueping
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Ansu
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China ; Anhui Province Key Laboratory of Biological Macro-molecules Research, Wannan Medical College, Wuhu, Anhui 241003, P.R. China.
authors.forename: Cui
authors.initials: C
authors.lastname: Yu
authors.affiliation: Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu, Anhui 241003, P.R. China.
authors.forename: Li-Zhuo
authors.initials: LZ
authors.lastname: Wang
keywords: glycemic control; hypoglycemia; insulin; treatment method