title: Estimation of in vivo and in vitro exposure to bisphenol A as food contaminant.
abstract: The goal of this cross-sectional study was to examine the occurrence of bisphenol A (BPA) in the morning spot urine taken from 145 female volunteers of various ages. Total urine BPA concentration was detected in 38.6% samples in the 0.92-70.96 μg/g Cr range. The majority of BPA + women belonged to the 25 + body mass index (BMI) group (54.5% were overweight and 43.4% were obese women). Occurrence of BPA in the urine samples was higher at 40 + ages. The maximum BPA concentration of 70.96 μg/g Cr was detected in the urine sample of an obese woman. It is known that BPA is highly toxic in vitro. In this study BPA impaired significantly the growth of all investigated cell lines, i.e. the EC50 values were reached at very low concentrations, in the range from 3.24 to 34.85 μg/mL. The obtained in vivo results suggest that a higher exposure to BPA could contribute to weight problems in women and the absence of the BPA in vitro selective toxicity studies indicates to its general toxic mode of action and raises awareness of the health risks associated with its ubiquitous presence in the environment.
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Milić
authors.affiliation: Experimental Oncology Department, Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Dr Goldmana 4, 21204 Sremska Kamenica, Serbia.
authors.forename: Dragana
authors.initials: D
authors.lastname: Četojević-Simin
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia. Electronic address: majam021@yahoo.com.
authors.forename: Maja
authors.initials: M
authors.lastname: Milanović
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
authors.forename: Jan
authors.initials: J
authors.lastname: Sudji
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Milošević
authors.affiliation: Center for Laboratory Medicine, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
authors.forename: Nikola
authors.initials: N
authors.lastname: Ćurić
authors.affiliation: Department of Health Sciences, University "Magna Graecia", Viale Europa - Germaneto, 88100 Catanzaro, Italy.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Abenavoli
authors.affiliation: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Medić-Stojanoska
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity* / Q000652:urine; D015992:Body Mass Index; D002274:Carcinogens, Environmental / Q000032:analysis / Q000633:toxicity*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003430:Cross-Sectional Studies; D052244:Endocrine Disruptors / Q000633:toxicity* / Q000652:urine; D004784:Environmental Monitoring; D005260:Female; D005506:Food Contamination; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000139:chemically induced* / Q000652:urine; D050177:Overweight / Q000139:chemically induced* / Q000652:urine; D010636:Phenols / Q000633:toxicity* / Q000652:urine; D051381:Rats; D055771:Serbia; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002274:Carcinogens, Environmental; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Endocrine disrupting compounds; Obesity; Toxicity; Urine