title: Polycyclic Aromatic Hydrocarbons in the Mainstream Smoke of Popular U.S. Cigarettes.
abstract: The mainstream smoke yields of 14 polycyclic aromatic hydrocarbons (PAHs) were determined for 50 commercial U.S. cigarettes using a validated GC/MS method with the International Organization of Standardization (ISO) and Canadian Intense (CI) smoking machine regimens. PAH mainstream smoke deliveries vary widely among the commercial cigarettes with the ISO smoking regimen primarily because of differing filter ventilation. The more abundant, lower molecular weight PAHs such as naphthalene, fluorene, and phenanthrene predominantly comprise the total PAH yields. In contrast, delivery yields of high molecular weight PAHs such as benzo[b]fluoranthene, benzo[e]pyrene, benzo[k]fluoranthene, and benzo[a]pyrene (BaP) are much lower. Comparative analysis of PAHs deliveries shows brand specific differences. Correlation analysis shows strong positive associations between BaP and most of the other PAHs as well as total PAHs. The results suggest that BaP may be a representative marker for other PAH constituents in cigarette smoke generated from similarly blended tobacco, particularly those PAHs with similar molecular weights and chemical structures.
authors.affiliation: †Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States.
authors.forename: An T
authors.initials: AT
authors.lastname: Vu
authors.affiliation: †Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Taylor
authors.affiliation: †Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Holman
authors.affiliation: ‡Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
authors.forename: Yan S
authors.initials: YS
authors.lastname: Ding
authors.affiliation: ‡Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
authors.forename: Bryan
authors.initials: B
authors.lastname: Hearn
authors.affiliation: ‡Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
authors.forename: Clifford H
authors.initials: CH
authors.lastname: Watson
mesh_terms: D015394:Molecular Structure; D008970:Molecular Weight; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis*; D012906:Smoke / Q000032:analysis*; D012907:Smoking; D062789:Tobacco Products / Q000032:analysis*; D014481:United States
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D012906:Smoke