title: Associations of Serum Isoflavone, Adiponectin and Insulin Levels with Risk for Epithelial Ovarian Cancer: Results of a Case-control Study.
abstract: BACKGROUND
  The aim of this study was to examine the association of serum isoflavones, adiponectin, and insulin levels with ovarian cancer risk.
  
  
  METHODS
  We gathered cases with histologically confirmed epithelial ovarian cancer at Sapporo Medical University Hospital from October 2010 to September 2012. Potential controls were recruited from female inpatients without any history of cancer or diabetes mellitus in different wards of the same hospital over the same period of time. Serum isoflavones, adiponectin, and insulin levels were measured in order to estimate associations with ovarian cancer risk in a case-control study. Data from 71 cases and 80 controls were analyzed with a logistic regression model adjusting for known risk factors.
  
  
  RESULTS
  A significant reduction in ovarian cancer risk was observed for the high tertile of serum daidzein level versus the low (Ptrend<0.001). A significant reduction in ovarian cancer risk was also observed for the high tertile of serum glycitein level versus the low (Ptrend=0.005). Furthermore, a significant reduction in ovarian cancer risk was observed for the high tertile of serum adiponectin level versus the low (Ptrend=0.004). Conversely, serum insulin level showed significantly elevated risk for ovarian cancer with the high tertile versus the low Ptrend<0.001).
  
  
  CONCLUSIONS
  Decreased serum isoflavones levels, such as those for daidzein and glycitein, decreased serum adiponectin levels, and increased serum insulin levels could be shown to be associated with elevated risk of ovarian cancer.
authors.affiliation: Department of Public Health, Sapporo Medical University School of Health Sciences, Sapporo, Japan E-mail : mitsurum@sapmed.ac.jp.
authors.forename: Seiko
authors.initials: S
authors.lastname: Otokozawa
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akasaka
authors.forename: Eiki
authors.initials: E
authors.lastname: Ito
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Asakura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Saito
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Miura
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saito
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Mori
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D061385:Insulins / Q000097:blood*; D007529:Isoflavones / Q000097:blood*; D016015:Logistic Models; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood*; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D061385:Insulins; D007529:Isoflavones; C004742:daidzein; C086566:glycitein