title: Advanced oxidation protein products in predicting acute kidney injury following cardiac surgery.
abstract: To test the hypothesis whether serum advanced oxidation protein products (AOPP) are associated with increased acute kidney injury (AKI) after cardiopulmonary bypass (CPB) and could serve as a biomarker in this aspect, we performed a prospective cohort study. Thirty-five (22.3%) patients developed AKI, and 32 age- and gender-matched patients without AKI were selected as control. Serum AOPP 1 h after CPB were significantly higher among AKI patients compared with non-AKI patients (81.8 ± 18.6 versus 67.4 ± 12.5 μmol/L, p < 0.001), with an area under the receiver-operating characteristic (ROC) curve of 0.714. An optimal serum AOPP 1 h after CPB cutoff of 69.9 μmol/L had a sensitivity of 74%, specificity of 63% and a positive predictive value of 68% for predicting AKI. These results demonstrated that serum AOPP might be an early biomarker for AKI after CPB.
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery and.
authors.forename: Song-lin
authors.initials: SL
authors.lastname: Du
authors.forename: Xiang-zhen
authors.initials: XZ
authors.lastname: Zeng
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Tian
authors.forename: Jun
authors.initials: J
authors.lastname: Ai
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.forename: Jian-xing
authors.initials: JX
authors.lastname: He
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology / Q000601:surgery; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers; D003404:Creatinine
keywords: Acute kidney injury; advanced oxidation protein products; cardiopulmonary bypass; early diagnosis; oxidative stress