title: Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.
abstract: OBJECTIVE
  Head and neck cancer is the sixth most common cancer in worldwide with an increasing incidence rate in recent years. LOXL4 is expressed in several tissues, and its expression has been shown to display a significant correlation with local lymph node metastasis. In this study, we aimed to explore the LOXL4 expression level in metastatic and non-metastatic LSCC tissues and to determine its prognostic significance.
  
  
  METHODS
  Basic science research study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A total of 40 patients were included in the study.
  
  
  METHODS
  LOXL4 expression status in metastatic, non-metastatic LSCC and normal tissue samples was investigated by quantitative reverse-transcription PCR.
  
  
  RESULTS
  We demonstrated that LOXL4 was significantly overexpressed in LSCC tumour tissue samples in comparison with the corresponding normal tissues (P < 0.001); however, no significant relationship has been found between LOXL4 expression and either the metastatic potential or the T classification of the specimens.
  
  
  CONCLUSIONS
  Although expression of LOXL4 is not statistically associated with neck metastases, we showed that LOXL4 expression significantly increased in laryngeal cancer.
authors.affiliation: Department of Otorhinolaryngology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Department of Medical Genetics, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Suer
authors.affiliation: Department of Medical Genetics, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey.|Department of Molecular Biology and Genetics, Erzurum Technical University, Erzurum, Turkey.
authors.forename: O F
authors.initials: OF
authors.lastname: Karatas
authors.affiliation: Department of Otorhinolaryngology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Cansiz
authors.affiliation: Department of Medical Genetics, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey.|Department of Molecular Biology and Genetics, Biruni University, Istanbul, Turkey.|Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ozen
mesh_terms: D000368:Aged; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D008249:Protein-Lysine 6-Oxidase; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D000594:Amino Acid Oxidoreductases; C445682:LOXL4 protein, human; D008249:Protein-Lysine 6-Oxidase