title: Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography.
abstract: We developed robust, three-dimensional methods, as opposed to traditional A-line analysis, for estimating the optical properties of calcified, fibrotic, and lipid atherosclerotic plaques from in vivo coronary artery intravascular optical coherence tomography clinical pullbacks. We estimated attenuation [Formula: see text] and backscattered intensity [Formula: see text] from small volumes of interest annotated by experts in 35 pullbacks. Some results were as follows: noise reduction filtering was desirable, parallel line (PL) methods outperformed individual line methods, root mean square error was the best goodness-of-fit, and [Formula: see text]-trimmed PL ([Formula: see text]-T-PL) was the best overall method. Estimates of [Formula: see text] were calcified ([Formula: see text]), fibrotic ([Formula: see text]), and lipid ([Formula: see text]), similar to those in the literature, and tissue classification from optical properties alone was promising.
authors.affiliation: Case Western Reserve University , Department of Biomedical Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Madhusudhana
authors.initials: M
authors.lastname: Gargesha
authors.affiliation: Case Western Reserve University , Department of Electrical Engineering and Computer Science, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Ronny
authors.initials: R
authors.lastname: Shalev
authors.affiliation: Case Western Reserve University , Department of Biomedical Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: David
authors.initials: D
authors.lastname: Prabhu
authors.affiliation: University Hospitals Case Medical Center , Harrington Heart and Vascular Institute, Cardiovascular Imaging Core Laboratory, 11100 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Case Western Reserve University , Department of Biomedical Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rollins
authors.affiliation: University Hospitals Case Medical Center , Harrington Heart and Vascular Institute, Cardiovascular Imaging Core Laboratory, 11100 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Marco
authors.initials: M
authors.lastname: Costa
authors.affiliation: University Hospitals Case Medical Center , Harrington Heart and Vascular Institute, Cardiovascular Imaging Core Laboratory, 11100 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Hiram G
authors.initials: HG
authors.lastname: Bezerra
authors.affiliation: Case Western Reserve University , Department of Biomedical Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States ; Case Western Reserve University , Department of Radiology, 11100 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: David L
authors.initials: DL
authors.lastname: Wilson
keywords: computational imaging; image analysis; optical coherence tomography