title: Amisulpride and symptomatic bradycardia: a case report.
abstract: OBJECTIVE
  Amisulpride is a second-generation antipsychotic agent indicated for the treatment of schizophrenia and other major psychotic illnesses. Amisulpride-induced bradycardia is a rare condition of unknown etiology and mechanism. Asymptomatic bradycardia has been associated with amisulpride in only two cases. In our case, the association was rated as "probable" on the Naranjo adverse drug reaction probability scale.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 45-year-old male patient developed symptomatic bradycardia during usage of amisulpride (400-800 mg/day), which dramatically improved after the complete termination of amisulpride usage. The psychiatric condition remained relatively stable without bradycardia after administration of another antipsychotic agent [risperidone (3 mg/day)].
  
  
  CONCLUSIONS
  This is the first case report of symptomatic bradycardia associated with the use of amisulpride. Although bradycardia is a rare adverse reaction to antipsychotics, this finding may alert psychiatrists and physicians to this antipsychotic drug side effect. Further study is needed to disclose the role of antipsychotics in bringing about symptomatic bradycardia.
authors.affiliation: Department of Psychiatry, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan; Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
authors.forename: Li-Chung
authors.initials: LC
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
authors.forename: Li-Yen
authors.initials: LY
authors.lastname: Huang
authors.affiliation: Department of Pharmachology, Taichung Veterans General Hospital Chia Yi Branch, Chia-Yi City, Taiwan.
authors.forename: Shih-Yen
authors.initials: SY
authors.lastname: Tseng
authors.affiliation: Department of Psychiatry, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan.
authors.forename: Yuh-Ming
authors.initials: YM
authors.lastname: Hou
authors.affiliation: Department of Psychiatry, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan. Electronic address: cych07209@gmail.com.
authors.forename: Cheng-Cheng
authors.initials: CC
authors.lastname: Hsiao
mesh_terms: D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001919:Bradycardia / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride
keywords: Adverse drug reaction; Amisulpride; Bradycardia; Psychotic disorder