title: Neuropsychological Performance in Polyconsumer Men Under Treatment. Influence of Age of Onset of Substance Use.
abstract: Neurocognition is a key factor in the development and maintenance of Substance Use Disorders (SUD). However, there are still several aspects that need to be studied in this area. In this study, we elucidate the influence of age of onset of substance use (OSU) on the clinical course and neuropsychological performance of substance use disorder (SUD) patients, as well as to explore the influence of years of education, duration of drug use and premorbid intelligence quotient (IQ) on the cognitive results obtained. An exhaustive neuropsychological battery was used to assess different cognitive domains in 80 male polyconsumers, 41 with earlier OSU (16 years or before: OSU ≤ 16) and 39 with later OSU (17 years or later: OSU ≥ 17). The patients were under treatment with at least 4 months of abstinence confirmed by urinalysis. The OSU ≤ 16 group presented a worse clinical state, as well as a lower premorbid IQ and worse performance in processing speed, visual perception and planning skills. The duration of drug use may account for the differences in planning and processing speed. In this work we discuss the premorbid or acquired nature of the cognitive deficits found.
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig Vall d'Hebrón 171, 08035 Barcelona, Spain.
authors.forename: Maria del Mar
authors.initials: Mdel M
authors.lastname: Capella
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig Vall d'Hebrón 171, 08035 Barcelona, Spain.
authors.forename: Irina
authors.initials: I
authors.lastname: Benaiges
authors.affiliation: 1] Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig Vall d'Hebrón 171, 08035 Barcelona, Spain [2] Institute for Brain, Cognition and Behavior (IR3C), Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Adan
mesh_terms: D000328:Adult; D017668:Age of Onset; D015897:Comorbidity; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012307:Risk Factors; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000523:psychology* / Q000628:therapy; D055815:Young Adult