title: A rare case of glycine encephalopathy unveiled by valproate therapy.
abstract: Glycine encephalopathy (GE) or nonketotic hyperglycinemia is an autosomal recessive disorder due to a primary defect in glycine cleavage enzyme system. It is characterized by elevated levels of glycine in plasma and cerebrospinal fluid usually presenting with seizures, hypotonia, and developmental delay. In our case, paradoxical increase in seizure frequency on starting sodium valproate led us to diagnose GE.
authors.affiliation: Department of Paediatric Neurology, Institute of Social Paediatrics, Stanley Medical College, Chennai, Tamil Nadu, India.
authors.forename: Velusamy
authors.initials: V
authors.lastname: Subramanian
authors.affiliation: Department of Biochemistry, Institute of Child Health, Madras Medical College, Chennai, Tamil Nadu, India.
authors.forename: Pramila
authors.initials: P
authors.lastname: Kadiyala
authors.affiliation: Intern, Stanley Medical College, Chennai, Tamil Nadu, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Hariharan
authors.affiliation: Department of Paediatrics, Institute of Social Paediatrics, Stanley Medical College, Chennai, Tamil Nadu, India.
authors.forename: E
authors.initials: E
authors.lastname: Neeraj
keywords: Glycine encephalopathy; nonketotic hyperglycinemia; organic acidemia; recurrent seizures; valproate