title: Expression and Significance of Cadherins and Its Subtypes in Development and Progression of Oral Cancers: A Review.
abstract: Cadherins are a family of transmembranous glycoproteins responsible for calcium-dependent intercellular adhesion. Absence or loss of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher invasiveness for extracellular matrices. That is why cadherin expression is considered to be a decisive indicator for differentiation, aggressive behaviour, high proliferation, metastasis, poor prognosis and invasiveness of human carcinoma cells. In this review, the role of cadherin expression was focused on, both in development and carcinogenesis, paying particular attention to mechanisms involved in its down-regulation. The elements common to this process in both physiological and pathological situations was analysed, particularly in relation to one of the most common malignancy, oral squamous cell carcinoma.
authors.affiliation: Senior Lecturer, Department of Oral Pathology, Eklavya Dental College and Hospital , Kotputli, Rajasthan, India .
authors.forename: Yogesh Chand
authors.initials: YC
authors.lastname: Rajwar
authors.affiliation: Reader, Department of Oral Pathology, Eklavya Dental College and Hospital , Kotputli, Rajasthan, India .
authors.forename: Nitul
authors.initials: N
authors.lastname: Jain
authors.affiliation: Senior Lecturer, Department of Periodontics, Eklavya Dental College and Hospital , Kotputli, Rajasthan, India .
authors.forename: Gouri
authors.initials: G
authors.lastname: Bhatia
authors.affiliation: Senior Lecturer, Department of Prosthodontics, PGIDS , Rohtak, India .
authors.forename: Neha
authors.initials: N
authors.lastname: Sikka
authors.affiliation: Senior Lecturer, Department of Oral & Maxillofacial Surgery, PGIDS , Rohtak, India .
authors.forename: Balram
authors.initials: B
authors.lastname: Garg
authors.affiliation: Private Practitioner, Department of Oral Pathology, Center Head, Axiss Dental Pvt Ltd , Faridabad, India .
authors.forename: Esha
authors.initials: E
authors.lastname: Walia
keywords: Cancer biomarkers; Cancer metastasis; Cell-cell adhesion; Desmosomes; Oral squamous cell carcinoma; Prognosis