title: [Looking through zebrafish to study host-pathogen interactions].
abstract: The zebrafish offers many advantages that motivated and validated its use to study the virulence of numerous human pathogens, including viruses, bacteria and fungi. Its immune system is homologous to the one of mammals. The optical transparency of zebrafish embryos allows non-invasive and real-time monitoring of the infection processes through the use of imaging techniques. The zebrafish is therefore a useful and powerful model to study host-pathogen interactions at a cellular level. It may be used to describe pathophysiological events and subversion mechanisms that are specific to each pathogen. In addition to increasing our understanding of the host immune defense, this model is of high potential for medical application, being particularly amenable to high-throughput screening for the discovery of new anti-infective molecules.
authors.affiliation: Centre d'étude des pathogènes pour la biotechnologie et la santé (CPBS), CNRS FRE3689, 1919, route de Mende, 34293 Montpellier Cedex 05, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Bernut
authors.affiliation: Laboratoire de dynamique des interactions membranaires normales et pathologiques, CNRS UMR5235, université de Montpellier, place Eugène Bataillon, Montpellier, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Lutfalla
authors.affiliation: Centre d'étude des pathogènes pour la biotechnologie et la santé (CPBS), CNRS FRE3689, 1919, route de Mende, 34293 Montpellier Cedex 05, France - Inserm, CPBS, 1919, route de Mende, 34293 Montpellier Cedex 05, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Kremer
mesh_terms: D000818:Animals; D001419:Bacteria / Q000472:pathogenicity; D004195:Disease Models, Animal; D004625:Embryo, Nonmammalian; D005658:Fungi / Q000472:pathogenicity; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D014780:Viruses / Q000472:pathogenicity; D015027:Zebrafish / Q000196:embryology / Q000254:growth & development / Q000276:immunology