title: Drosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response.
abstract: Aging is characterized by the accumulation of dysfunctional mitochondria. Since these organelles are involved in many important cellular processes, different mechanisms exist to maintain their integrity. Among them is the mitochondrial unfolding protein response, which triggers the expression of a set of proteins aimed at re-establishing mitochondrial homeostasis. The induction of mitochondrial chaperones expression, particularly of Hsp60 and Hsp70, is a hallmark of this pathway. In Drosophila melanogaster, Hsp22 is also up-regulated by mitochondrial stress. This small heat shock protein is one of the members of the family to be localized inside mitochondria. One characteristic of Drosophila Hsp22 is its preferential up-regulation during aging and in oxidative stress conditions. It is a beneficial protein since its over-expression increases lifespan and resistance to stress while its down-regulation is detrimental. This review focuses on Drosophila Hsp22 and its links with the mitochondrial unfolding protein response and the aging process, in addition to highlight the important role of this sHSP in mitochondrial homeostasis.
authors.affiliation: Laboratoire de Génétique Cellulaire et Développementale, Département de biologie moléculaire, biochimie médicale et pathologie, Institute de Biologie Intégrative et des Systèmes (IBIS) and PROTEO, Université Laval, Pavillon CE-Marchand, 1030 avenue de la médecine, Québec, QC, G1V 0A6, Canada.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Morrow
authors.affiliation: Laboratoire de Génétique Cellulaire et Développementale, Département de biologie moléculaire, biochimie médicale et pathologie, Institute de Biologie Intégrative et des Systèmes (IBIS) and PROTEO, Université Laval, Pavillon CE-Marchand, 1030 avenue de la médecine, Québec, QC, G1V 0A6, Canada.
authors.forename: Marie
authors.initials: M
authors.lastname: Le Pécheur
authors.affiliation: Laboratoire de Génétique Cellulaire et Développementale, Département de biologie moléculaire, biochimie médicale et pathologie, Institute de Biologie Intégrative et des Systèmes (IBIS) and PROTEO, Université Laval, Pavillon CE-Marchand, 1030 avenue de la médecine, Québec, QC, G1V 0A6, Canada. robert.tanguay@ibis.ulaval.ca.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Tanguay
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D000071256:Uncoupling Protein 1
chemical_list: D029721:Drosophila Proteins; D006360:Heat-Shock Proteins; C490752:Hsp22 protein, Drosophila; D007473:Ion Channels; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1
keywords: Aging; Hsp22; Mitochondrial unfolding protein response (UPRMT); Oxidative stress; Reactive oxygen species (ROS); Small heat shock protein (sHSP)