title: Disulfide-bridged peptide macrobicycles from nature.
abstract: Disulfide-bridged peptide bicycles (DBPBs) are molecules that contain a transannular disulfide bridge within a macrocyclic framework. While DBPBs are precedented in nature, the development of synthetic analogues and their use as therapeutic agents has yet to realize their full potential. A series of naturally-occurring DBPBs and their respective structural and biological features is presented, followed by a description of synthetic methods used to prepare and understand these unique bicyclic systems. The synergy of high-throughput biology and synthetic chemistry should facilitate the development of novel DBPBs in the near future.
authors.affiliation: Lash Miller Chemical Laboratories, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6. ayudin@chem.utoronto.ca.
authors.forename: Benjamin K W
authors.initials: BK
authors.lastname: Chung
authors.forename: Andrei K
authors.initials: AK
authors.lastname: Yudin
mesh_terms: D004220:Disulfides / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D004220:Disulfides; D010455:Peptides