title: Case of plasmablastic lymphoma of the sigmoid colon and literature review.
abstract: Plasmablastic lymphoma (PBL) is a rare form of non-Hodgkin's lymphoma that is associated with human immunodeficiency virus (HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. This report represents an unusual case of HIV-negative PBL that occurred in the sigmoid colon. This patient had a history of systemic lupus erythematosus and an underlying immunosuppressive state from long term steroid therapy. The lymphoma cells were positive for CD138, kappa light chain restriction and Epstein-Barr virus and negative for CD20/L26, CD3, CD79a, UCHL1 (CD45RO) and cytokeratin (AE1/AE3). The patient died approximately 2 mo after the operation. In the present paper, we review cases of PBL of the colon in HIV-negative patients.
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Haramura
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Haraguchi
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Irie
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ito
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tokai
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Noda
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Masachika
authors.initials: M
authors.lastname: Kitajima
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Minami
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Sasaki
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Oshima
authors.affiliation: Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology; D000069293:Plasmablastic Lymphoma / Q000276:immunology / Q000473:pathology* / Q000601:surgery / Q000821:virology; D012811:Sigmoid Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery / Q000821:virology; D013256:Steroids / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D013256:Steroids
keywords: Extra-oral site; Human immunodeficiency virus-negative; Immunosuppressive state; Plasmablastic lymphoma; Sigmoid colon