title: Microvessels Density in Uterine Leiomyosarcoma.
abstract: Uterine leiomyosarcomas (LMS) are rare tumors typically presenting rapid growth and unfavorable outcome. Nowadays the results of uterine LMS treatment do not meet expectations. Angiogenesis is one of processes investigated to be target for future treatment. The aim of the research was to assess microvessels density (MVD) in tumor samples collected from 50 patients with histological confirmed uterine leiomyosarcoma and to investigate statistical relations between MVD, patients survival, and FIGO stage of tumor. The assessment was carried out using immunohistochemistry methods with anti-CD34 antibody. No significant difference in MVD between FIGO stages was observed. Furthermore, contrary to many other malignancies, we found no significant relation between MVD and patients overall and 2-year survival. Results obtained in the study suggest that processes on vascular mimicry and mesenchymal to epithelial transition (MET) may play important role in development of LMS. No statistical relation between MVD and survival leads to conclusion that not only angiogenesis but other mechanisms as well should be taken into consideration in planning future research.
authors.affiliation: 1st Chair and Department of Gynaecological Oncology and Gynaecology, Medical University in Lublin, 16 Staszica Street, 20-081 Lublin, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Bobiński
authors.affiliation: 1st Chair and Department of Gynaecological Oncology and Gynaecology, Medical University in Lublin, 16 Staszica Street, 20-081 Lublin, Poland.
authors.forename: Wiesława
authors.initials: W
authors.lastname: Bednarek
authors.affiliation: Chair and Department of Clinical Pathomorphology, Medical University in Lublin, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Szumiło
authors.affiliation: Chair and Department of Biochemistry and Molecular Biology, Medical University in Lublin, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Cybulski
authors.affiliation: 1st Chair and Department of Gynaecological Oncology and Gynaecology, Medical University in Lublin, 16 Staszica Street, 20-081 Lublin, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Polak
authors.affiliation: 1st Chair and Department of Gynaecological Oncology and Gynaecology, Medical University in Lublin, 16 Staszica Street, 20-081 Lublin, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Kotarski
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007890:Leiomyosarcoma / Q000098:blood supply* / Q000473:pathology*; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D016019:Survival Analysis; D014594:Uterine Neoplasms / Q000098:blood supply* / Q000473:pathology*
chemical_list: D018952:Antigens, CD34