title: Association between serum ferritin and lipid peroxidation in hemodialysis patients.
abstract: BACKGROUND
  Iron supplementation is one of the recommendations found in patients with chronic kidney disease (CKD), however, an overload of this mineral can contribute to oxidative stress, a condition closely related to the cardiovascular risk in these patients, as well as disease progression.
  
  
  OBJECTIVE
  The objective of this study was to investigate whether ferritin levels are associated with oxidative stress marker MDA in patients on hemodialysis (HD).
  
  
  METHODS
  Twenty HD patients (55.0 ± 15.2 years, time of dialysis 76.5 ± 46.3 months, BMI 23.6 ± 3.0 kg/m2) were compared with 11 healthy subjects (50.9 ± 8.0 years, BMI 23.8 ± 1.9 kg/m2). Malondialdehyde (MDA) was measured by reaction with thiobarbituric acid and routine biochemical data were obtained from medical records.
  
  
  RESULTS
  MDA levels were significantly higher in HD patients compared to the control group (13.2 ± 5.3 nmol/mL vs. 5.1 ± 2.7nmol/mL, p < 0.01). Twelve patients (60%) had ferritin values greater than the 500 ng/mL and there was a positive correlation between ferritin and MDA in HD (r = 0.66, p = 0.005, n = 17) patients.
  
  
  CONCLUSIONS
  The excess iron stores in HD patients results in increased lipid peroxidation, and consequently contributes to increased oxidative stress in these patients.
authors.affiliation: Universidade Federal Fluminense, Brazil.
authors.forename: Liliana M
authors.initials: LM
authors.lastname: Pedruzzi
authors.affiliation: Universidade Federal Fluminense, Brazil.
authors.forename: Ludmila Ferreira Medeiros de França
authors.initials: LF
authors.lastname: Cardozo
authors.affiliation: Universidade Federal Fluminense, Brazil.
authors.forename: Renata F
authors.initials: RF
authors.lastname: Medeiros
authors.affiliation: Universidade Federal Fluminense, Brazil.
authors.forename: Milena B
authors.initials: MB
authors.lastname: Stockler-Pinto
authors.affiliation: Universidade Federal Fluminense, Brazil.
authors.forename: Denise
authors.initials: D
authors.lastname: Mafra
mesh_terms: D015415:Biomarkers / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism* / Q000628:therapy*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D005293:Ferritins