title: Synthesis and Nematicidal Activities of 1,2,3-Benzotriazin-4-one Derivatives against Meloidogyne incognita.
abstract: A series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized by the reaction of 3-bromoalkyl-1,2,3-benzotriazin-4-ones with potassium salt of 2-cyanoimino-4-oxothiazolidine in the presence of potassium iodide. Nematicidal assays in vivo showed that some of them exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita, up to 100% at the concentration of 10.0 mg L(-1), which indicated that 1,2,3-benzotriazin-4-one derivatives might be potential for novel promising nematicides. The nematicidal activity was influenced by the combination of substituent type, substituted position, and linker length in the molecule. The inhibition rate data at the concentrations of 5.0 and 1.0 mg L(-1) for the compounds with high inhibitory activities were also provided. When tested in vitro, none of them showed direct inhibition against M. incognita. The investigation of a significant difference between in vivo and in vitro data is in progress.
authors.affiliation: †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
authors.forename: Gaolei
authors.initials: G
authors.lastname: Wang
authors.affiliation: †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
authors.forename: Xiulei
authors.initials: X
authors.lastname: Chen
authors.affiliation: †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
authors.forename: Yayun
authors.initials: Y
authors.lastname: Deng
authors.affiliation: †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.|‡Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Li
authors.affiliation: †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.|‡Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Xu
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D018553:Cucumis sativus / Q000469:parasitology; D015394:Molecular Structure; D010935:Plant Diseases / Q000469:parasitology; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D014431:Tylenchoidea / Q000187:drug effects* / Q000502:physiology
chemical_list: D000969:Antinematodal Agents; D014227:Triazines; C102393:1,2,3-benzotriazin-4-one
keywords: 1,2,3-benzotriazin-4-one; 2-cyanoiminothiazolidin-4-one; Meloidogyne incognita; in vivo; nematicide