title: Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand.
abstract: Our preclinical data demonstrate that an intravenous injection of Modified Vaccinia virus Ankara induces CD8+lymphocytes to infiltrate organs to control the growth of orthotopic renal carcinoma upon combination with a toll-like receptor 9 agonist. Such shaping of the tumor microenvironment could constitute the basis of more effective clinical protocols of tumor immunotherapy.
authors.affiliation: Transgene S.A.; Illkirch-Graffenstaden ; Strasbourg, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Préville
authors.affiliation: Transgene S.A.; Illkirch-Graffenstaden ; Strasbourg, France.
authors.forename: Karola
authors.initials: K
authors.lastname: Rittner
authors.affiliation: Transgene S.A.; Illkirch-Graffenstaden ; Strasbourg, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Fend
keywords: MUC1; MVA; TLR9; immunotherapy; orthotopic; renal carcinoma