title: Paraneoplastic cerebellar degeneration in a patient with ovarian cancer.
abstract: OBJECTIVE
  Herein, we report a case of ovarian serous carcinoma with paraneoplastic cerebellar degeneration.
  
  
  METHODS
  A 44-year-old female presented to our hospital with dizziness, slurred speech, and ataxic gait. Brain magnetic resonance imaging was normal. A lumbar puncture revealed a normal cell count in the cerebrospinal fluid, but slightly elevated protein. Her serum cancer antigen -125 level was high (2126.4 U/mL), and abdominal computed tomography disclosed a pelvic mass measuring 11 cm in diameter. Exploratory laparotomy was then performed, and a frozen section of the tumor revealed serous carcinoma.
  
  
  CONCLUSIONS
  According to the surgical findings and pathological report, The International Federation of Gynecology and Obstetrics (FIGO) Stage IIIC, Grade 3, serous-type ovarian cancer was diagnosed. Due to the abovementioned symptoms and signs, we performed a serial test to document the presence of anti-Yo antibody in this patient.
authors.affiliation: Department of Obstetrics and Gynecology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
authors.forename: Hung-Ju
authors.initials: HJ
authors.lastname: Chien
authors.affiliation: Department of Neurology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
authors.forename: Chuo-Yu
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Neurology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
authors.forename: Lu-An
authors.initials: LA
authors.lastname: Chen
authors.affiliation: Department of Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan.
authors.forename: Chao-Chih
authors.initials: CC
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan; Department of Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan; Department of Medicine, Mackay Medical College, Shanchi, New Taipei City, Taiwan. Electronic address: cl_chang@yahoo.com.
authors.forename: Chih-Long
authors.initials: CL
authors.lastname: Chang
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D004244:Dizziness / Q000209:etiology; D005260:Female; D020234:Gait Ataxia / Q000209:etiology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000032:analysis; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology*; D013064:Speech Disorders / Q000209:etiology
chemical_list: C095184:CDR2 protein, human; D009419:Nerve Tissue Proteins
keywords: anti-Yo antibody; ovarian cancer; paraneoplastic cerebellar degeneration