title: Chiral Metallo-Supramolecular Complex Directed Enantioselective Self-Assembly of β-Sheet Breaker Peptide for Amyloid Inhibition.
abstract: Chiral recognition plays an important role for biomacromolecules involved self-assembly and further affects their biological functions. Herein, it is demonstrated that two chiral metal complexes can enantioselectively bind with Aβ15-20, leading to the formation of different self-assembled nanostructures. With the ability of both metal complexes and Aβ15-20 to inhibit Aβ1-40 aggregation, the NiM@P hybrid particles can act as bifunctional Aβ inhibitors.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Chuanqi
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D000818:Animals; D052160:Benzothiazoles; D006801:Humans; D007700:Kinetics; D053768:Metal Nanoparticles / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D036103:Nanotechnology; D016716:PC12 Cells; D017433:Protein Structure, Secondary; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D013696:Temperature; D013844:Thiazoles / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D052160:Benzothiazoles; D008670:Metals; D013844:Thiazoles; C009462:thioflavin T
keywords: Alzheimer's disease; Aβ15-20; chiral metallo-supramolecular complexes; enantioselectivity; self-assembly