title: Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population.
abstract: Clinicopathological characteristics of small gastric carcinoma have not been well defined in Chinese patients. The aim of this study was to investigate and compare small proximal (PGC, n = 111) with distal (DGC, n = 202) gastric carcinoma in 313 consecutive surgically resected small (≤2 cm) gastric carcinomas diagnosed with the WHO criteria. PGC patients were significantly older (average age 63 years versus 59 in DGCs) with a male/female ratio of 3:1. Most tumours were clustered along the lesser curvature (74% in PGCs and 65% in DGCs). Compared to DGCs, PGCs showed a protruded gross pattern significantly more frequently and were significantly better differentiated with a significantly wider histomorphological spectrum. Surprisingly, PGCs were composed of significantly fewer signet-ring cell carcinomas (1% versus 16% in DGCs) but were significantly more deeply invasive, compared to DGCs. Lymph node metastasis was detected in 23% overall, but was significantly less frequent in PGCs (16%) than in DGCs (26%) (p < 0.05). However, the difference in survival between the two groups was not statistically significant. Our results demonstrate that in Chinese patients, PGCs display distinct clinicopathological characteristics, compared to DGCs.
authors.affiliation: 1Department of Pathology, the Nanjing Drum Tower Hospital, Nanjing, China 2Department of Pathology and Laboratory Medicine, Veterans Affairs Boston Healthcare System, West Roxbury 3Harvard Medical School, Boston 4Department of Surgery, Veterans Affairs Boston Healthcare System, West Roxbury 5Department of Gastroenterology, Veterans Affairs Boston Healthcare System, West Roxbury, MA, United States 6Department of Gastroenterology, the Nanjing Drum Tower Hospital, Nanjing, China 7Department of Emergency Medicine, Boston Medical Center, Boston 8Department of Pathology, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: Qin
authors.initials: Q
authors.lastname: Huang
authors.forename: Jiong
authors.initials: J
authors.lastname: Shi
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Jason S
authors.initials: JS
authors.lastname: Gold
authors.forename: Jieyu
authors.initials: J
authors.lastname: Chen
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wu
authors.forename: Huiping
authors.initials: H
authors.lastname: Yu
authors.forename: Yifen
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mashimo
authors.forename: Chenggong
authors.initials: C
authors.lastname: Yu
authors.forename: Travis
authors.initials: T
authors.lastname: Manasco
authors.forename: Wenyan
authors.initials: W
authors.lastname: Guan
authors.forename: Gregory Y
authors.initials: GY
authors.lastname: Lauwers
mesh_terms: D044466:Asian People; D002277:Carcinoma / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*