title: Biochemical protective effect of 1,25-dihydroxyvitamin D3 through autophagy induction in the MPTP mouse model of Parkinson's disease.
abstract: In our previous study, the neuroprotective effect of calcitriol was confirmed in SH-SY5Y cells. In this article, we explored whether calcitriol showed neuroprotection in a subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson's disease. After mice were treated with MPTP alone or cotreated with MPTP and calcitriol, the substantia nigra pars compacta was dissected, and related protein levels were detected by western blot. Our results suggest that the MPTP-injected mice treated with calcitriol had attenuated tyrosine hydroxylase expression and increased LC3-II conversion compared with those that were not. Above all, calcitriol showed neuroprotection in the MPTP mouse model.
authors.affiliation: aNatural Products Research Center, Korea Institute of Science and Technology Departments of bNeurology cRehabilitation Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine dBiomedical Research Center, Gangneung Asan Hospital, Gangneung eDepartment of Biological Chemistry, University of Science & Technology (UST), Daejeon, Republic of Korea fCollege of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Li
authors.forename: Wooyoung
authors.initials: W
authors.lastname: Jang
authors.forename: Hee Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Kwang Deog
authors.initials: KD
authors.lastname: Jo
authors.forename: Moon Kyu
authors.initials: MK
authors.lastname: Lee
authors.forename: Sun Hong
authors.initials: SH
authors.lastname: Song
authors.forename: Hyun Ok
authors.initials: HO
authors.lastname: Yang
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects* / Q000502:physiology; D002117:Calcitriol / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D020734:Parkinsonian Disorders / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D065842:Pars Compacta / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D018696:Neuroprotective Agents; D002117:Calcitriol