title: Synthesis and spectral studies of metal complexes of a Schiff base derived from (2-amino-5-chlorophenyl)phenyl methanone.
abstract: Some new complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Fe(III) with the Schiff base 5-chloro-2-(furan-2-yl methylamino)phenyl)phenyl methanone has been synthesized and characterized by elemental analysis, spectroscopic data including FT-IR, (1)H NMR, Electronic, ESI mass, Mössbauer & ESR. It has been found that the Schiff base behaves as a neutral bidentate N, O donor which chelates with the metal ions in 1:2 stoichiometry. Magnetic moment and electrolytic conductance data confirms this. The Schiff base and selected complexes were screened for antimicrobial activity. The complexes and the Schiff base were subjected to antioxidant study. The antitumor activity of Co(II) complex was tested by MTT assay. The result indicates the viability of the complex against tested cell lines.
authors.affiliation: University College, M G Road, Palayam, Thiruvananthapuram 695 034, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Mini
authors.affiliation: University College, M G Road, Palayam, Thiruvananthapuram 695 034, Kerala, India. Electronic address: sadasivan.v@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Sadasivan
authors.affiliation: Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
authors.forename: S S
authors.initials: SS
authors.lastname: Meena
authors.affiliation: Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
authors.forename: Pramod
authors.initials: P
authors.lastname: Bhatt
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D056831:Coordination Complexes; D008670:Metals; D012545:Schiff Bases
keywords: (2-Amino-5-chlorophenyl)phenyl methanone; 2-Amino-5-chlorobenzophenone; Mössbauer spectra