title: Incidence and Clinical Significance of Poststent Optical Coherence Tomography Findings: One-Year Follow-Up Study From a Multicenter Registry.
abstract: BACKGROUND
  Optical coherence tomography (OCT) was recently introduced to optimize percutaneous coronary intervention. However, the exact incidence and significance of poststent OCT findings are unknown.
  
  
  RESULTS
  A total of 900 lesions treated with 1001 stents in 786 patients who had postprocedure OCT imaging were analyzed to evaluate the incidence of poststent OCT findings and to identify the OCT predictors for device-oriented clinical end points, including cardiac death, target vessel-related myocardial infarction, target lesion revascularization, and stent thrombosis. Patients were followed up to 1 year. Stent edge dissection was detected in 28.7% of lesions, and incomplete stent apposition was detected in 39.1% of lesions. The incidences of smooth protrusion, disrupted fibrous tissue protrusion, and irregular protrusion were 92.9%, 61.0%, and 53.8%, respectively. Small minimal stent area, defined as a lesion with minimal stent area <5.0 mm(2) in a drug-eluting stent or <5.6 mm(2) in a bare metal stent, was observed in 40.4% of lesions. One-year device-oriented clinical end points occurred in 33 patients (4.5%). Following adjustment, irregular protrusion and small minimal stent area were independent OCT predictors of 1-year device-oriented clinical end points (P=0.003 and P=0.012, respectively).
  
  
  CONCLUSIONS
  Abnormal poststent OCT findings were frequent. Irregular protrusion and small minimal stent area were independent predictors of 1-year device-oriented clinical end points, which were primarily driven by target lesion revascularization.
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Tsunenari
authors.initials: T
authors.lastname: Soeda
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Shiro
authors.initials: S
authors.lastname: Uemura
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Seung-Jung
authors.initials: SJ
authors.lastname: Park
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Stephen
authors.initials: S
authors.lastname: Lee
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Jin-Man
authors.initials: JM
authors.lastname: Cho
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Soo-Joong
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Rocco
authors.initials: R
authors.lastname: Vergallo
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Minami
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Ong
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Hang
authors.initials: H
authors.lastname: Lee
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Shaosong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.). yubodr@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.).
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Saito
authors.affiliation: From Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.S., R.V., Y.M., D.S.O., L.G., I.-K.J.); First Department of Medicine, Nara Medical University, Kashihara, Japan (T.S., S.U., Y.S.); Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-J.P.,); Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (Y.J.); Queen Mary Hospital, Hong Kong University, Hong Kong (S.L.); Division of Cardiology, Kyung Hee University, Seoul, Republic of Korea (J.-M.C., S.-J.K., I.-K.J.); Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (H.L.,); and Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China (S.Z., B.Y.). yubodr@163.com.
authors.forename: Ik-Kyung
authors.initials: IK
authors.lastname: Jang
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000628:therapy*; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology*; D012042:Registries; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*; D013927:Thrombosis / Q000175:diagnosis / Q000453:epidemiology*; D041623:Tomography, Optical Coherence / Q000379:methods; D016896:Treatment Outcome
keywords: diagnostic imaging; optical coherence tomography; stents