title: Roles of DPY30 in the Proliferation and Motility of Gastric Cancer Cells.
abstract: Various types of histone methylation have been associated with cancer progression. Depending on the methylation site in histone proteins, its effects on transcription are different. DPY30 is a common member of SET1/MLL histone H3K4 methyltransferase complexes. However, its expression and roles in gastric cancer have been poorly characterized. To determine whether DPY30 has pathophysiological roles in gastric cancer, its expression and roles were examined. Immunohistochemistry and real time PCR showed up-regulation of DPY30 expression in some gastric cancer cell lines and patients' tissues. Its knockdown by siRNA decreased the proliferation, migration, and invasion of gastric cancer cells, whereas its overexpression showed the opposite effects. These results indicate that DPY30 has critical roles in the proliferation, migration, and invasion of gastric cancer cells, and suggest DPY30 might be a therapeutic target in gastric cancer.
authors.affiliation: Departments of Anatomy, School of Medicine, Pusan National University, Busan, Republic of Korea.
authors.forename: Yong Joo
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Departments of Anatomy, School of Medicine, Pusan National University, Busan, Republic of Korea; Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Busan, Republic of Korea.
authors.forename: Myoung-Eun
authors.initials: ME
authors.lastname: Han
authors.affiliation: Medical Genomics Research Center, KRIBB, Daejeon, Republic of Korea.
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Baek
authors.affiliation: Medical Genomics Research Center, KRIBB, Daejeon, Republic of Korea.
authors.forename: Seon-Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Departments of Anatomy, School of Medicine, Pusan National University, Busan, Republic of Korea.
authors.forename: Sae-Ock
authors.initials: SO
authors.lastname: Oh
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D014157:Transcription Factors
chemical_list: C507432:DPY30 protein, human; D009687:Nuclear Proteins; D014157:Transcription Factors