title: Investigation of effects of myricetin on thyroid-gonadal axis of male rats at prepubertal period.
abstract: The present study is to investigate the effects of myricetin on pubertal development and thyroid hormone concentrations in the male rat. The rats were exposed to 25 and 50mg/kg/day of myricetin by gavage from post natal day (PND) 23 to 53. Preputial separation (PPS), organ weights and biochemical and hormone analysis were investigated. PPS was significantly delayed in low dose myricetin groups. Total serum thyroxine (T4) and, triiodothyronine (T3) levels increased in 25mg/kg myricetin dose group but thyroid-stimulating hormone (TSH) level increased in 0.7 μg/kg/day ethinyl estradiol dose groups. Myricetin exposure did not significantly change androgen dependent tissue weights; however myricetin exposure caused congestion, germinal cell debris and tubular atrophy in testis colloidal and tubular degeneration in thyroid gland were observed while there was germinal cell debris in epididymis. This study demonstrated that orally gavages myricetin caused adverse effects on male thyroid-gonadal axis during peripubertal period to pubertal period.
authors.affiliation: Akdeniz University, Faculty of Medicine, Department of Histology and Embryology, 07058 Campus Antalya, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Okan
authors.affiliation: Hacettepe University, Faculty of Science, Department of Biology, 06532 Beytepe, Ankara, Turkey. Electronic address: nurhayatbarlas3@gmail.com.
authors.forename: Nurhayat
authors.initials: N
authors.lastname: Barlas
authors.affiliation: Hacettepe University, Faculty of Science, Department of Biology, 06532 Beytepe, Ankara, Turkey.
authors.forename: Gözde
authors.initials: G
authors.lastname: Karabulut
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004997:Ethinyl Estradiol / Q000008:administration & dosage; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*; D013961:Thyroid Gland / Q000187:drug effects*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D005419:Flavonoids; D014284:Triiodothyronine; D004997:Ethinyl Estradiol; C040015:myricetin; D013974:Thyroxine
keywords: Flavonoid; Myricetin; Phytoestrogens; Prepubertal male rat; Thyroid axis