title: Controlled release of anti-diabetic drug Gliclazide from poly(caprolactone)/poly(acrylic acid) hydrogels.
abstract: Drug Gliclazide (Glz) has limited solubility and low bioavailability. In order to obtain a controlled release of this drug and to improve its bioavailability, the drug has been loaded into poly(caprolactone) (PCL)/poly(acrylic acid) (PAAc) hydrogels, prepared by free radical polymerization of acrylic acid in the presence of poly(caprolactone) in acetone medium using azo-isobutyronitrile as initiator and N,N' methylene bisacrylamide as cross-linking agent. The swelling behaviour of these hydrogels has been investigated in the physiological gastric and intestinal fluids to obtain an optimum composition suitable for delivery of a biologically active compound. The gels were loaded with anti-diabetic drug Glz and a detailed investigation of release of drug has been carried out. Various kinetic models have been applied on the release data. Finally, the Albino wistar rats were treated for Streptozotocin plus nicotinamide - induced diabetes using a Glz-loaded PCL/PAAc hydrogel. The results indicated a fair reduction in the glucose level of rats.
authors.affiliation: a Polymer Research Lab, Department of Chemistry , Govt. Model Science College , Jabalpur , M.P. , India.
authors.forename: S K
authors.initials: SK
authors.lastname: Bajpai
authors.forename: Navin
authors.initials: N
authors.lastname: Chand
authors.forename: Shweta
authors.initials: S
authors.lastname: Soni
mesh_terms: D000096:Acetone / Q000737:chemistry; D000178:Acrylamides / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D002208:Caproates / Q000737:chemistry; D003692:Delayed-Action Preparations; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D005744:Gastric Acid / Q000378:metabolism; D005907:Gliclazide / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005947:Glucose / Q000378:metabolism; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007419:Intestinal Secretions / Q000378:metabolism; D007700:Kinetics; D007783:Lactones / Q000737:chemistry; D008958:Models, Molecular; D009570:Nitriles / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D058105:Polymerization; D017208:Rats, Wistar; D014867:Water / Q000737:chemistry
chemical_list: D000178:Acrylamides; D000179:Acrylates; D000180:Acrylic Resins; D002208:Caproates; D003692:Delayed-Action Preparations; D020100:Hydrogels; D007004:Hypoglycemic Agents; D007783:Lactones; D009570:Nitriles; D011091:Polyesters; D014867:Water; D000096:Acetone; C016240:polycaprolactone; C006903:carbopol 940; C121056:caprolactone; C022246:isobutyronitrile; C021221:N,N'-methylenebisacrylamide; D005907:Gliclazide; D005947:Glucose; C036658:acrylic acid
keywords: biodegradable polymer; diabetes; hydrogel; swelling