title: Effect of Danlou Tablet () on peri-procedural myocardial injury among patients undergoing percutaneous coronary intervention for non-ST elevation acute coronary syndrome: A study protocol of a multicenter, randomized, controlled trial.
abstract: BACKGROUND
  It has been shown that administration of statins reduced the risk of peri-procedural myocardial damage. However, it remains unclear whether Chinese medicine Danlou Tablet (), similar to statins, may protect patients undergoing percutaneous coronary intervention (PCI) from peri-procedural myocardial damage.
  
  
  OBJECTIVE
  To demonstrate the hypothesis whether treatment with Danlou Tablet would improve clinical outcome in patients undergoing selective PCI with non-ST elevation acute coronary syndrome (NSTE-ACS) in China.
  
  
  METHODS
  Approximately 220 patients with unstable angina or non-ST-segment elevation myocardial infarction undergoing PCI will be enrolled and randomized to Danlou Tablet treatment (4.5 g/day for 2 days before intervention, with a further 4.5 g/day for 90 days thereafter) or placebo. All patients will not receive Danlou Tablet before procedure. The primary end point is to evaluate the incidence of cardiac death, myocardial infarction or unplanned re-hospitalization and revascularization after 30 days in patients undergoing selective PCI treated with Danlou Tablet compared with placebo. Secondary endpoints include the incidence of peri-procedural myocardial injury, 3-month clinical outcomes, the quality of life and Chinese medicine syndromes assessment.
  
  
  CONCLUSIONS
  This study protocol will provide important evidence of Danlou Tablet treatment on the peri-procedural myocardial injury in patients with NSTE-ACS undergoing selective PCI, which may support a strategy of routine Danlou Tablet therapy to improve the clinical outcomes.
authors.affiliation: The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.|Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.|Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Mao
authors.affiliation: Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
authors.forename: Jian-yong
authors.initials: JY
authors.lastname: Qi
authors.affiliation: Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
authors.affiliation: The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.|Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
authors.forename: Xin-feng
authors.initials: XF
authors.lastname: Guo
authors.affiliation: Department of Cardiovascular Disease, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Ke-ji
authors.initials: KJ
authors.lastname: Chen
authors.affiliation: The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. minzhouzhang@aliyun.com.|Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China. minzhouzhang@aliyun.com.
authors.forename: Min-zhou
authors.initials: MZ
authors.lastname: Zhang
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004562:Electrocardiography; D023381:Endpoint Determination; D006801:Humans; D009206:Myocardium / Q000473:pathology*; D062645:Percutaneous Coronary Intervention; D018401:Sample Size; D014463:Ultrasonography
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Chinese medicine; Danlou Tablet; non-ST-segment elevation acute coronary syndrome; percutaneous coronary intervention; peri-procedural myocardial infarction