title: The association of aphasia and right-sided motor impairment in corticobasal syndrome.
abstract: Corticobasal syndrome is defined clinically on the basis of symptoms and findings related to dysfunction of the cerebral cortex and the basal ganglia. Usually, marked asymmetry of motor findings is observed. Although aphasia has now been recognized as a frequent feature of corticobasal syndrome, it remains unclear whether it is usually associated with right-sided motor symptoms, pointing to the involvement of the left hemisphere. Hence, we set out to examine the relationship between the presence of language symptoms and the side affected by extrapyramidal symptoms. We analyzed the electronic care records of patients seen in the years 2003-2013 in the Neurology Department of the University Hospital of Munich. The diagnosis of corticobasal syndrome was discussed in ninety-two individuals. Of those, 38 cases fulfilled diagnostic criteria for corticobasal syndrome. Aphasia correlated highly with a predominant right-sided movement disorder (p = 0.002). In contrast, it was less common in patients with left-sided motor presentation. Dysarthria did not show a preferential correlation (p = 0.25). Our analysis suggests a characteristic presentation of corticobasal syndrome in which motor dysfunction of the right side of the body is associated with aphasia.
authors.affiliation: Neurology Department, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany. johannes.levin@med.uni-muenchen.de.
authors.forename: Johannes
authors.initials: J
authors.lastname: Levin
authors.affiliation: Department of Psychology and Centre for Clinical Brain Sciences, Edinburgh University, Edinburgh, UK.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Bak
authors.affiliation: Department of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Rominger
authors.affiliation: Department of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Erik
authors.initials: E
authors.lastname: Mille
authors.affiliation: Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Arzberger
authors.affiliation: Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Armin
authors.initials: A
authors.lastname: Giese
authors.affiliation: Neurology Department, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Nibal
authors.initials: N
authors.lastname: Ackl
authors.affiliation: Neurology Department, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Lorenzl
authors.affiliation: Neurology Department, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Bader
authors.affiliation: Department of Neuroradiology, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Patzig
authors.affiliation: Neurology Department, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Bötzel
authors.affiliation: Neurology Department, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.|German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
authors.forename: Adrian
authors.initials: A
authors.lastname: Danek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001037:Aphasia / Q000209:etiology / Q000503:physiopathology*; D001480:Basal Ganglia Diseases / Q000150:complications / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004401:Dysarthria / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology*
keywords: Aphasia; Corticobasal degeneration; Corticobasal syndrome; Dementia; Dysarthria; Parkinsonism