title: Brugada syndrome and its relevance in the perioperative period.
abstract: Brugada syndrome is an autosomal dominant genetic disorder associated with an increased risk of sudden cardiac death, as well as ventricular tachyarrhythmias.The defective cardiac sodium channels result in usual electrocardiographic findings of a coved-type ST elevation in precordial leads V1 to V3. The majority of patients have uncomplicated courses with anesthesia, surgery, and invasive procedures. However there is risk of worsening ST elevation and ventricular arrhythmias due to perioperative medications, surgical insult, electrolyte abnormalities, fever, autonomic nervous system tone, as well as other perturbations. Given the increasing numbers of patients with inherited conduction disorders presenting for non-cardiac surgery that are at risk of sudden cardiac death, safe anesthetic management depends upon a detailed knowledge of these conditions.
authors.forename: Dan
authors.initials: D
authors.lastname: Sorajja
authors.forename: Harish
authors.initials: H
authors.lastname: Ramakrishna
authors.forename: A Karl
authors.initials: AK
authors.lastname: Poterack
authors.forename: Win-Kuang
authors.initials: WK
authors.lastname: Shen
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Arizona, AZ 85259, USA.
authors.forename: Farouk
authors.initials: F
authors.lastname: Mookadam
mesh_terms: D053840:Brugada Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D059035:Perioperative Period; D017180:Tachycardia, Ventricular / Q000517:prevention & control*