title: Quality of Sexual Life in Women with Primary Sjögren Syndrome.
abstract: OBJECTIVE
  To assess the quality of sexual life of women with primary Sjögren syndrome (pSS) and to identify its correlations with disease activity and damage, quality of life, and mood disorders.
  
  
  METHODS
  The quality of sexual life of 24 women with pSS was assessed with the Female Sexual Function Index (FSFI). Twenty-four healthy women, matched by age and hormonal status, were enrolled as controls. Mood disorders and quality of life were investigated using the Hospital Anxiety and Depression Scale (HADS) and the Medical Outcomes Study Short Form-36. Patients underwent a gynecological visit with vaginal pH measurement, cervicovaginal swabs, and Pap smears. Disease activity and damage were assessed by the European League Against Rheumatism Sjögren syndrome disease activity and damage indexes.
  
  
  RESULTS
  Patients with pSS showed a pathological mean FSFI score (19.1 ± 7.33) significantly different from controls (p = 0.004), both in menstruating women (p = 0.006) and in menopausal women (p = 0.03). Major differences between the 2 groups were detected in dyspareunia (p < 0.005), lubrication (p = 0.006), desire (p = 0.004), and arousal (p = 0.018). The FSFI score was inversely correlated with age (p = 0.008) and anxiety HADS (p = 0.031). No early anatomical changes, swabs, and Pap smear alterations were revealed in patients with pSS; however, vaginal pH was higher than normal in premenopausal patients (6.0 ± 0.77).
  
  
  CONCLUSIONS
  Both premenopausal and postmenopausal women with pSS have a worse sexual quality of life. We reported a greater prevalence of dyspareunia that is statistically significant when compared with controls. The FSFI could be a useful tool to assess this topic, but has been neglected in the care of patients with pSS heretofore.
authors.affiliation: From the Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, and Department of Gynecological and Obstetrical Sciences and Urological Sciences, Gynecology Clinic, Sapienza University of Rome; Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health, Rome, Italy.R. Priori, MD, PhD; A. Minniti, MD; B. Antonazzo, MD; F. Brancatisano, MD; G. Valesini, Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome; M. Derme, MD; M. Framarino-dei-Malatesta, MD, PhD, Gynecology Clinic, Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome; S. Ghirini, MSc, Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health.
authors.forename: Roberta
authors.initials: R
authors.lastname: Priori
authors.affiliation: From the Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, and Department of Gynecological and Obstetrical Sciences and Urological Sciences, Gynecology Clinic, Sapienza University of Rome; Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health, Rome, Italy.R. Priori, MD, PhD; A. Minniti, MD; B. Antonazzo, MD; F. Brancatisano, MD; G. Valesini, Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome; M. Derme, MD; M. Framarino-dei-Malatesta, MD, PhD, Gynecology Clinic, Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome; S. Ghirini, MSc, Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health.
authors.forename: Antonina
authors.initials: A
authors.lastname: Minniti
authors.affiliation: From the Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, and Department of Gynecological and Obstetrical Sciences and Urological Sciences, Gynecology Clinic, Sapienza University of Rome; Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health, Rome, Italy.R. Priori, MD, PhD; A. Minniti, MD; B. Antonazzo, MD; F. Brancatisano, MD; G. Valesini, Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome; M. Derme, MD; M. Framarino-dei-Malatesta, MD, PhD, Gynecology Clinic, Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome; S. Ghirini, MSc, Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health.
authors.forename: Martina
authors.initials: M
authors.lastname: Derme
authors.affiliation: From the Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, and Department of Gynecological and Obstetrical Sciences and Urological Sciences, Gynecology Clinic, Sapienza University of Rome; Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health, Rome, Italy.R. Priori, MD, PhD; A. Minniti, MD; B. Antonazzo, MD; F. Brancatisano, MD; G. Valesini, Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome; M. Derme, MD; M. Framarino-dei-Malatesta, MD, PhD, Gynecology Clinic, Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome; S. Ghirini, MSc, Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health.
authors.forename: Barbara
authors.initials: B
authors.lastname: Antonazzo
authors.affiliation: From the Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, and Department of Gynecological and Obstetrical Sciences and Urological Sciences, Gynecology Clinic, Sapienza University of Rome; Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health, Rome, Italy.R. Priori, MD, PhD; A. Minniti, MD; B. Antonazzo, MD; F. Brancatisano, MD; G. Valesini, Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome; M. Derme, MD; M. Framarino-dei-Malatesta, MD, PhD, Gynecology Clinic, Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome; S. Ghirini, MSc, Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health.
authors.forename: Filippo
authors.initials: F
authors.lastname: Brancatisano
authors.affiliation: From the Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, and Department of Gynecological and Obstetrical Sciences and Urological Sciences, Gynecology Clinic, Sapienza University of Rome; Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health, Rome, Italy.R. Priori, MD, PhD; A. Minniti, MD; B. Antonazzo, MD; F. Brancatisano, MD; G. Valesini, Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome; M. Derme, MD; M. Framarino-dei-Malatesta, MD, PhD, Gynecology Clinic, Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome; S. Ghirini, MSc, Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health.
authors.forename: Silvia
authors.initials: S
authors.lastname: Ghirini
authors.affiliation: From the Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, and Department of Gynecological and Obstetrical Sciences and Urological Sciences, Gynecology Clinic, Sapienza University of Rome; Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health, Rome, Italy.R. Priori, MD, PhD; A. Minniti, MD; B. Antonazzo, MD; F. Brancatisano, MD; G. Valesini, Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome; M. Derme, MD; M. Framarino-dei-Malatesta, MD, PhD, Gynecology Clinic, Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome; S. Ghirini, MSc, Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health. guido.valesini@uniroma1.it.
authors.forename: Guido
authors.initials: G
authors.lastname: Valesini
authors.affiliation: From the Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, and Department of Gynecological and Obstetrical Sciences and Urological Sciences, Gynecology Clinic, Sapienza University of Rome; Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health, Rome, Italy.R. Priori, MD, PhD; A. Minniti, MD; B. Antonazzo, MD; F. Brancatisano, MD; G. Valesini, Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome; M. Derme, MD; M. Framarino-dei-Malatesta, MD, PhD, Gynecology Clinic, Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome; S. Ghirini, MSc, Population Health and Health Determinant Unit, National Centre for Surveillance, Prevention and Health Promotion, National Institute of Health.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Framarino-dei-Malatesta
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008593:Menopause / Q000523:psychology; D008875:Middle Aged; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*; D012725:Sexual Behavior / Q000523:psychology*; D012859:Sjogren's Syndrome / Q000523:psychology*
keywords: FEMALE SEXUAL FUNCTION INDEX; FSFI; SEXUAL LIFE; SJÖGREN SYNDROME