title: Stereoselective Electrophilic Cyclization.
abstract: Electrophilic cyclizations of unactivated alkenes play highly important roles in the synthesis of useful building blocks. This account describes our contributions to the rational design of monofunctionalized chiral Lewis base catalysts for enantioselective iodo- and protocyclizations. For the stereoselective promotion of electrophilic bromocyclizations, nucleophilic phosphite-urea cooperative catalysts have been designed.
authors.affiliation: Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Sakakura
authors.affiliation: Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, (Japan) and Japan Science and Technology Agency (JST), CREST, Furo-cho, Chikusa, Nagoya, 464-8603, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D054879:Halogenation; D007783:Lactones / Q000737:chemistry*; D058115:Lewis Bases / Q000737:chemistry*; D017905:Phosphites / Q000737:chemistry; D013237:Stereoisomerism; D014508:Urea / Q000737:chemistry
chemical_list: D000475:Alkenes; D007783:Lactones; D058115:Lewis Bases; D017905:Phosphites; D014508:Urea
keywords: Lewis bases; asymmetric synthesis; electrophilic cyclization; lactonization; organocatalysis