title: Negative symptom domain prevalence across diagnostic boundaries: The relevance of diagnostic shifts.
abstract: Negative symptoms are included in diagnostic manuals as part of criteria for schizophrenia spectrum psychoses only, however some studies have found their presence in other diagnoses. This study sought to clarify negative symptom domain prevalence across diagnostic categories, while investigating whether negative symptoms predicted diagnostic shift over time. Scale for the Assessment of Negative Symptoms (SANS) data were collected at first presentation in 197 individuals presenting with first episode psychosis and again at one year follow-up assessment. Negative symptoms were highest among individuals with schizophrenia and among those whose diagnosis shifted from non-schizophrenia spectrum at baseline to schizophrenia spectrum at follow-up. In a non-schizophrenia spectrum group negative symptoms at baseline were not a significant predictor of diagnostic shift to schizophrenia spectrum diagnoses. The study suggests negative symptoms can present among individuals with non-schizophrenia spectrum diagnoses, although this is most relevant for individuals following diagnostic shift from non-schizophrenia spectrum to schizophrenia spectrum diagnoses. The findings support introduction of a negative symptom dimension when describing a range of psychotic illnesses, and indicate that further research investigating the evolution of negative symptoms in non-schizophrenia diagnoses is needed.
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock, Co. Dublin, Ireland; College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland; Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland; The School of Psychotherapy, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: johnlyne@mail.com.
authors.forename: John
authors.initials: J
authors.lastname: Lyne
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock, Co. Dublin, Ireland; College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland; Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland; The School of Psychotherapy, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Laoise
authors.initials: L
authors.lastname: Renwick
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock, Co. Dublin, Ireland; College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland; Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland; The School of Psychotherapy, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Brian
authors.initials: B
authors.lastname: O'Donoghue
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock, Co. Dublin, Ireland; Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland; The School of Psychotherapy, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Anthony
authors.initials: A
authors.lastname: Kinsella
authors.affiliation: Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland; The School of Psychotherapy, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; Department of Psychiatry, Psychotherapy and Mental Health Research, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Elm Park, Dublin 4, Ireland.
authors.forename: Kevin
authors.initials: K
authors.lastname: Malone
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock, Co. Dublin, Ireland; Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland; The School of Psychotherapy, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Niall
authors.initials: N
authors.lastname: Turner
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock, Co. Dublin, Ireland; Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland; The School of Psychotherapy, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; St. John of God Community Services Ltd., Blackrock, Co. Dublin, Ireland.
authors.forename: Eadbhard
authors.initials: E
authors.lastname: O'Callaghan
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock, Co. Dublin, Ireland; Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland; The School of Psychotherapy, St. Vincent's University Hospital/School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; St. John of God Community Services Ltd., Blackrock, Co. Dublin, Ireland.
authors.forename: Mary
authors.initials: M
authors.lastname: Clarke
mesh_terms: D000293:Adolescent; D000328:Adult; D001526:Behavioral Symptoms; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis* / Q000453:epidemiology*; D012565:Schizophrenic Psychology; D055815:Young Adult
keywords: Diagnosis; Negative symptoms; Persistent; Psychosis; Schizophrenia; Transdiagnostic