title: DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.
abstract: Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia. The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence. A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.The two variants might therefore be grouped into a unified category.
authors.affiliation: Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland. Hala.Kannuna@hcuge.ch.
authors.forename: Hala
authors.initials: H
authors.lastname: Kannuna
authors.affiliation: Department of Pathology, Karolinska University Hospital, Stockholm, Sweden. Carlos.Rubio@ki.se.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Rubio
authors.affiliation: Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland. Patricia.CaseiroSilverio@hcuge.ch.
authors.forename: Patricia Caseiro
authors.initials: PC
authors.lastname: Silverio
authors.affiliation: Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland. Marc.Girardin@hcuge.ch.
authors.forename: Marc
authors.initials: M
authors.lastname: Girardin
authors.affiliation: Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland. Nicolas.Goossens@hcuge.ch.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Goossens
authors.affiliation: Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland. Laura.Rubbia-Brandt@hcuge.ch.
authors.forename: Laura
authors.initials: L
authors.lastname: Rubbia-Brandt
authors.affiliation: Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland. giacomo.puppa@hcuge.ch.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Puppa
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000145:classification / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002430:Cecal Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology* / Q000601:surgery; D003082:Colectomy; D003110:Colonic Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology* / Q000601:surgery; D003113:Colonoscopy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008221:Lymphoid Tissue / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010641:Phenotype; D011237:Predictive Value of Tests; D009626:Terminology as Topic; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor