title: Association of three 8q24 polymorphisms with prostate cancer susceptibility: evidence from a meta-analysis with 50,854 subjects.
abstract: The 8q24 polymorphisms have been implicated in various cancers. Three 8q24 polymorphisms (rs1447295 C>A, rs16901979 C>A, and rs6983267 T>G) have been extensively investigated for their association with prostate cancer (PCa) susceptibility, yet conclusions are contradictory. We conducted a comprehensive meta-analysis to reevaluate the associations between those polymorphisms and PCa susceptibility, according to the latest meta-analysis guidelines (PRISMA). Eligible publications were searched from MEDLINE, EMBASE and CBM. False positive report possibility analysis was performed. We totally collected 20184 cases and 20439 controls from 20 studies for the rs1447295 C>A, 1850 cases and 2090 controls from 7 studies for the rs16901979 C>A, and 12233 cases and 7582 controls from 17 studies for the rs6983267 T>G. Overall, each of studied 8q24 polymorphisms was significantly associated with PCa risk individually. Significant associations were also observed in stratified analysis by ethnicity, source of control, and quality score. Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans. The effect of rs16901979 was more prominent among Africa-Americans than Asians. Likewise, rs6983267 conferred a higher Pca risk among Caucasians than Asians. Collectively, these 8q24 variant(s) may modulate PCa risk in an ethnic-specific manner.
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi, Xinjiang, 830054, China.
authors.forename: Qiaoxin
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi, Xinjiang, 830054, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Oncology, First affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Er Road, Guangzhou, Guangdong, 510080, China.
authors.forename: Rui-Xi
authors.initials: RX
authors.lastname: Hua
authors.affiliation: Department of Uorology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi, Xinjiang, 830054, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Uorology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi, Xinjiang, 830054, China.
authors.forename: Hengqing
authors.initials: H
authors.lastname: An
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi, Xinjiang, 830054, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Molecular Epidemiology Laboratory and Department of Laboratory Medicine, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, Heilongjang, 150040, China.
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D044466:Asian People / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics