title: Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence.
abstract: Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean ± SD 13.4 ± 2.2 years) were matched on age and sex to healthy controls. Common nouns were presented simultaneously from visual and auditory sensory inputs in "match" and "mismatch" conditions. Neuromagnetic responses M1, M2, M3, M4, and M5 with latencies of ~100 ms, ~150 ms, ~250 ms, ~350 ms, and ~450 ms, respectively, elicited during the "match" condition were identified. Compared to healthy children, epilepsy patients had both significantly delayed latency of the M1 and reduced amplitudes of M3 and M5 responses. These results provide neurophysiologic evidence of altered word recognition in children with intractable epilepsy.
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Pardos
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA ; Milena's Functional Brain Mapping and Brain-Computer Interface Lab, Florida Hospital for Children, Orlando, FL 32803, USA ; Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, FL 32803, USA ; MEG Lab, Florida Hospital for Children, Orlando, FL 32803, USA.
authors.forename: Milena
authors.initials: M
authors.lastname: Korostenskaja
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Hisako
authors.initials: H
authors.lastname: Fujiwara
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA ; Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, FL 32803, USA.
authors.forename: Ki H
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA ; Division of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45299, USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Horn
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Byars
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA ; Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Research Foundation and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Vannest
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA ; Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Nat
authors.initials: N
authors.lastname: Hemasilpin
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Rose
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D007802:Language; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology*; D016896:Treatment Outcome