title: Implications of understanding the signaling, cellular, and cytotoxic mechanisms afforded by afucosylated antibodies.
abstract: Afucosylated antibodies potentiate natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC) by enhancing signaling pathways and cellular processes, which in turn, increases cytotoxic potential. Importantly, a better understanding of these processes and properties will aid in exploiting them to help design therapeutic antibodies and strategies that may be of the greatest benefit to patients.
authors.affiliation: Department of Pathology; Genentech, Inc. ; San Francisco, CA, USA.
authors.forename: Scot D
authors.initials: SD
authors.lastname: Liu
authors.affiliation: Department of Pathology; Genentech, Inc. ; San Francisco, CA, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Lowe
keywords: afucosylated therapeutic antibodies; antibody-dependent cellular cytotoxicity; cellular processes; natural killer cells; obinutuzumab; rituximab; signaling; trastuzumab