title: Nanofibers used for delivery of antimicrobial agents.
abstract: Nanotechnology has gained an increased interest in several different areas of biotechnology including the drug delivery via nanofibers. Self-assembly, phase separation and electrospinning can all be used to successfully generate nanofibers with sizes well within the range of those of the fibers present in the native extracellular matrix (50-500 nm). In this article, the authors introduced the most popular applications of nanofibers related to the delivery of antimicrobial agents for infectious diseases. To date, only a few in-vivo studies are available at present to demonstrate its clinical potential; most of the studies are of exploratory nature and rely mostly on in-vitro experiments. Therefore, further advancement in the production and clinical performance of drug-loaded nanofibrous matrices seems necessary.
authors.affiliation: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Dave Wei-Chih
authors.initials: DW
authors.lastname: Chen
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan.
authors.forename: Shih-Jung
authors.initials: SJ
authors.lastname: Liu
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry; D004058:Diffusion; D015195:Drug Design; D004595:Electroplating / Q000379:methods*; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size
chemical_list: D000890:Anti-Infective Agents; D053769:Nanocapsules
keywords: antimicrobial agent; drug delivery system; infection; nanofiber