title: Association of TCF7L2 Polymorphism with Diabetic Nephropathy in the South Indian Population.
abstract: The transcription factor 7-like 2 (TCF7L2) gene plays a significant role in the development of type 2 diabetes and diabetic nephropathy. The aim of this study was to investigate the association of TCF7L2 rs12255372 (G/T)polymorphism with type 2 diabetic nephropathy in the South Indian population. A total of 2102 subjects, 927 normal glucose tolerant (NGT) subjects, 598 type 2 diabetic subjects without nephropathy (DM), and 577 type 2 diabetic subjects with nephropathy (DN) were genotyped by MassARRAY. As compared to the NGT group, the odds ratio (adjusted for age, sex, BMI, HbA1c, and systolic BP) computed for the GT/TT genotype taking the GG genotype as reference was found to be 2.02 (95% CI: 1.16-3.51, p = 0.013) for DN and 1.94 (95% CI: 1.36-2.78, p = 0.0002) for DM. The genotype frequency was not significantly different between the DM and DN groups. In conclusion, the rs12255372 polymorphism in the TCF7L2 gene is associated with type 2 diabetes and DN but its association with DN is mediated through diabetes.
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Dhanasekaran
authors.initials: D
authors.lastname: Bodhini
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.|Qatar Cardiovascular Research Centre, Qatar.
authors.forename: Manickam
authors.initials: M
authors.lastname: Chidambaram
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Samuel
authors.initials: S
authors.lastname: Liju
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Visvanathan G
authors.initials: VG
authors.lastname: Prakash
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Gayathri
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Coimbatore S
authors.initials: CS
authors.lastname: Shanthirani
authors.affiliation: Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention & Control, IDF Centre of Education, Chennai, India.
authors.forename: Unnikrishnan
authors.initials: U
authors.lastname: Ranjith
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.|Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention & Control, IDF Centre of Education, Chennai, India.
authors.forename: Ranjit M
authors.initials: RM
authors.lastname: Anjana
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.|Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention & Control, IDF Centre of Education, Chennai, India.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Radha
keywords: TCF7L2 gene; diabetic nephropathy; rs12255372 variant; south Indians; type 2 diabetes