title: New cytotoxic constituents from the Red Sea soft coral Nephthea sp.
abstract: Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2-9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.
authors.affiliation: a Phytochemistry Department and Center of Excellence for Advanced Sciences, National Research Centre , 33 El Bohouth st. (Former El Tahrir st.) Dokki, Giza, P.O. Box 12622, Egypt.
authors.forename: Mohamed-Elamir F
authors.initials: ME
authors.lastname: Hegazy
authors.affiliation: b Cancer Biology Lab, Center of Excellence for Advanced Sciences, and Biochemistry Department, National Research Centre , 33 El Bohouth st. (Former El Tahrir st.) Dokki, Giza, P.O. Box 12622, Egypt.
authors.forename: Amira M
authors.initials: AM
authors.lastname: Gamal-Eldeen
authors.affiliation: a Phytochemistry Department and Center of Excellence for Advanced Sciences, National Research Centre , 33 El Bohouth st. (Former El Tahrir st.) Dokki, Giza, P.O. Box 12622, Egypt.
authors.forename: Tarik A
authors.initials: TA
authors.lastname: Mohamed
authors.affiliation: c National Institute of Oceanography and Fisheries, Red Sea Branch , Hurghada 84511 , Egypt.
authors.forename: Montaser A
authors.initials: MA
authors.lastname: Alhammady
authors.affiliation: d Department of Chemistry , Faculty of Science, Suez University , Egypt.
authors.forename: Abuzeid A
authors.initials: AA
authors.lastname: Hassanien
authors.affiliation: e National Institute of Oceanography & Fisheries , Alexandria , Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Shreadah
authors.affiliation: d Department of Chemistry , Faculty of Science, Suez University , Egypt.
authors.forename: Ibrahim I
authors.initials: II
authors.lastname: Abdelgawad
authors.affiliation: e National Institute of Oceanography & Fisheries , Alexandria , Egypt.
authors.forename: Eman M
authors.initials: EM
authors.lastname: Elkady
authors.affiliation: f Department of Chemistry and Biochemistry , Texas Tech University , Lubbock , TX 79409 , USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Paré
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D019156:Indian Ocean; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D013256:Steroids
keywords: Nephthea sp.; breast cancer cell line MCF-7; cytotoxicity; terpenes