title: Cranberry anthocyanin extract prolongs lifespan of fruit flies.
abstract: Cranberry is an excellent source of dietary antioxidants. The present study investigated the effect of cranberry anthocyanin (CrA) extract on the lifespan of fruit flies with focus on its interaction with aging-related genes including superoxide dismutase (SOD), catalase (CAT), methuselah (MTH), insulin receptor (InR), target of rapamycin (TOR), hemipterus (Hep), and phosphoenolpyruvate carboxykinase (PEPCK). Results showed that diet containing 20mg/mL CrA could significantly prolong the mean lifespan of fruit flies by 10% compared with the control diet. This was accompanied by up-regulation of SOD1 and down-regulation of MTH, InR, TOR and PEPCK. The stress resistance test demonstrated that CrA could reduce the mortality rate induced by H2O2 but not by paraquat. It was therefore concluded that the lifespan-prolonging activity of CrA was most likely mediated by modulating the genes of SOD1, MTH, InR, TOR and PEPCK.
authors.affiliation: Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: Yuk Man
authors.initials: YM
authors.lastname: Li
authors.affiliation: Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lei
authors.affiliation: Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Wang
authors.affiliation: Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: Ka Ying
authors.initials: KY
authors.lastname: Ma
authors.affiliation: Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. Electronic address: zhenyuchen@cuhk.edu.hk.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Chen
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects*; D008136:Longevity / Q000187:drug effects / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D016896:Treatment Outcome; D015854:Up-Regulation / Q000187:drug effects; D029799:Vaccinium macrocarpon
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D029721:Drosophila Proteins; D010936:Plant Extracts
keywords: Anthocyanins; Antioxidants; Cranberry; Insulin receptor; Target of rapamycin