title: Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial.
abstract: OBJECTIVE
  To compare the efficacy and safety of two different second-generation ablation devices, Novasure impedance control system and microwave endometrial ablation (MEA), in cases of abnormal uterine bleeding (AUB).
  
  
  METHODS
  This is a randomized controlled trial that took place in a single Gynecological Department of a University Hospital. Sixty-six women with dysfunctional uterine bleeding (DUB), unresponsive to medical treatment, were included in the trial. The ratio of women allocated to bipolar radio-frequency ablation or MEA was 1:1. Follow-up assessments were carried out at three and 12 months post-ablation. The present main outcome measure was amenorrhea rates 12-months post-treatment.
  
  
  RESULTS
  The rate of amenorrhea at 12-months post-ablation was significantly higher in women treated by Novasure (25/33; 75.8%) as compared to those treated by MEA (8/33; 24.2%) (rate difference: +51.5%, 95% CI: +27.8 to +67.7).
  
  
  CONCLUSIONS
  In women with DUB, endometrial ablation with Novasure bipolar radiofrequency impedance-controlled system is associated with increased rates of amenorrhea at 12-months post-treatment as compared to the MEA method.
authors.forename: D
authors.initials: D
authors.lastname: Athanatos
authors.forename: G
authors.initials: G
authors.lastname: Pados
authors.forename: C A
authors.initials: CA
authors.lastname: Venetis
authors.forename: P
authors.initials: P
authors.lastname: Stamatopoulos
authors.forename: D
authors.initials: D
authors.lastname: Rousso
authors.forename: D
authors.initials: D
authors.lastname: Tsolakidis
authors.forename: C P
authors.initials: CP
authors.lastname: Stamatopoulos
authors.forename: B C
authors.initials: BC
authors.lastname: Tarlatzis
mesh_terms: D000328:Adult; D000568:Amenorrhea; D017115:Catheter Ablation / Q000379:methods*; D004311:Double-Blind Method; D017097:Electric Impedance / Q000627:therapeutic use; D055356:Endometrial Ablation Techniques; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000601:surgery*; D008796:Metrorrhagia / Q000601:surgery*; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome