title: The First Case of Deceased Donor Liver Transplantation for a Patient with End-Stage Liver Cirrhosis Due to Human Immunodeficiency Virus and Hepatitis C Virus Coinfection in Japan.
abstract: We previously reported that progression of liver cirrhosis is quicker and survival is dismal in patients with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection, especially when acquired in childhood through contaminated blood products. Recently, we performed the first deceased donor liver transplantation (DDLT) for an HIV/HCV-coinfected hemophilic patient in Japan. A 40-year-old man was referred to our hospital for liver transplantation. Regular DDLT was performed using the piggyback technique with a full-sized liver graft. Cold ischemia time was 465 min, and the graft liver weighed 1,590 g. The antiretroviral therapy (ART) was switched from darunavir/ritonavir to raltegravir before the transplant for flexible usage of calcineurin inhibitors postoperatively; tenofovir was used as the baseline treatment. The postoperative course was uneventful, and the patient was discharged home on day 43. He started receiving anti-HCV treatment on day 110 with pegylated interferon, ribavirin, and simeprevir after the DDLT. Herein, we report the first case of DDLT in Japan. Meticulous management of ART and clotting factors could lead to the success of DDLT.
authors.affiliation: Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences.
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Takatsuki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Soyama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hidaka
authors.forename: Tota
authors.initials: T
authors.lastname: Kugiyama
authors.forename: Koji
authors.initials: K
authors.lastname: Natsuda
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Adachi
authors.forename: Amane
authors.initials: A
authors.lastname: Kitasato
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Fujita
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kuroki
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006801:Humans; D007564:Japan; D016031:Liver Transplantation; D008297:Male; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents