title: Response to Dual Antiplatelet Therapy Does Not Impact Bleeding Risks in Patients Undergoing Oral Surgery after Acute Coronary Syndromes.
abstract: BACKGROUND
  Oral surgery (OS) in patients on antecedent dual antiplatelet therapy (DAPT) may be associated with extra bleeding risks. Monitoring platelet activity in such patients may be beneficial for safety when performing OS.
  
  
  OBJECTIVE
  The aim of this study was to assess whether platelet function during DAPT impacted the risk of bleeding following OS in patients with acute coronary syndromes (ACS).
  
  
  METHODS
  Patients who required OS on top of DAPT with aspirin and clopidogrel (n = 55) for invasively treated ACS were included. The control group (n = 33) consisted of patients who underwent OS with no antiplatelet agent. Platelet aggregation before OS was assessed with a Multiplate® analyzer. Bleeding during OS and at days 1, 3, 7 and 10 after surgery was serially evaluated.
  
  
  RESULTS
  All 88 patients completed the study. An incomplete response to aspirin or clopidogrel was observed in 43.6% of the patients. In 11% of the cases, an excessive response to clopidogrel was demonstrated. No excessive bleeding upon OS was exhibited in either group during the entire follow-up. Platelet aggregation values and the use of DAPT did not impact the performance of OS.
  
  
  CONCLUSIONS
  Therapy with clopidogrel and aspirin after ACS does not seem to increase the risk of real-life bleeding following OS, regardless of the platelet activity response to DAPT. © 2015 S. Karger AG, Basel.
authors.affiliation: Dental Surgery Clinic, Torun, Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Dudek
authors.forename: Wiktor
authors.initials: W
authors.lastname: Kuliczkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Kaczmarski
authors.forename: Joanna
authors.initials: J
authors.lastname: Wiechec
authors.forename: Edyta
authors.initials: E
authors.lastname: Reichman-Warmusz
authors.forename: Oliwia
authors.initials: O
authors.lastname: Segiet
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Helewski
authors.forename: Romuald
authors.initials: R
authors.lastname: Wojnicz
authors.forename: Victor L
authors.initials: VL
authors.lastname: Serebruany