title: Size characterization of commercial micelles and microemulsions by Taylor dispersion analysis.
abstract: In this work, Taylor dispersion analysis was applied to the measurement of micelles (or microdroplets) molecular diffusion coefficient in micellar (or microemulsion) systems based on neutral/anionic/cationic or zwitterionic surfactants. The choice of the micellar marker and the influence the surfactant/marker concentrations on this determination are studied. Experimental results are compared to those derived from the literature using other experimental techniques. Taylor dispersion analysis, experienced in narrow capillaries, was found to be an efficient and suitable method for micelle (or microdroplet) size measurement due to: the low sample consumption, the absence of filtration requirement of the sample, the broad range of size determination (with no lower limit down to angstroms), the simplicity of the protocol, the possibility to measure the viscosity of surfactant solutions in given conditions and the determination of the weight-average micelle hydrodynamic radius. Application to the size-characterization of commercial microemulsions (Gelucire(®) 44/14), used as an excipient in the pharmaceutical formulation, is provided with a comparison to DLS measurements. It was found that the polydispersity in size of the micelle did not influence the Gaussian peak shape of the taylorgram due to rapid surfactant exchange compared to the time-scale of the experiments (a few minutes).
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM, UMR 5247, CNRS, Université de Montpellier, Ecole Nationale Supérieure de Chimie de Montpellier), Place Eugène Bataillon, CC 1706, 34095 Montpellier, France.
authors.forename: Joseph
authors.initials: J
authors.lastname: Chamieh
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM, UMR 5247, CNRS, Université de Montpellier, Ecole Nationale Supérieure de Chimie de Montpellier), Place Eugène Bataillon, CC 1706, 34095 Montpellier, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Davanier
authors.affiliation: GATTEFOSSE SAS, 36, Chemin de Genas, 69804 Saint-Priest, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Jannin
authors.affiliation: GATTEFOSSE SAS, 36, Chemin de Genas, 69804 Saint-Priest, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Demarne
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM, UMR 5247, CNRS, Université de Montpellier, Ecole Nationale Supérieure de Chimie de Montpellier), Place Eugène Bataillon, CC 1706, 34095 Montpellier, France. Electronic address: herve.cottet@umontpellier.fr.
authors.forename: Hervé
authors.initials: H
authors.lastname: Cottet
mesh_terms: D002623:Chemistry Techniques, Analytical; D016503:Drug Delivery Systems; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D008823:Micelles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D004655:Emulsions; D005079:Excipients; D008823:Micelles; D013501:Surface-Active Agents; C104509:gelucire 44-14; D011092:Polyethylene Glycols
keywords: Brij 35 (PubChem CID: 2724258); Brij 58 (PubChem CID: 2724259); C12E6 (PubChem CID: 18282); CHAPS (PubChem CID: 107670); Cetyltrimethylammonium bromide (CTAB) (PubChem CID: 5974); Diffusion coefficient; Hydrodynamic radius; Micelles; Microemulsions; Pharmaceutical excipient; Sodium dodecyl sulfate (PubChem CID: 3423265); Sodium taurocholate (PubChem CID: 23666345); Taylor dispersion analysis; Tween 20 (PubChem CID: 443314)