title: A coupled non-Fickian model of a cardiovascular drug delivery system.
abstract: A coupled non-Fickian model of a cardiovascular drug delivery system using a biodegradable drug-eluting stent is proposed. The numerical results are obtained using an implicit-explicit finite-element method. The influence of vessel stiffness on the transport of drug eluted from the stent is analysed. The results presented in this paper suggest new perspectives to adapt the drug delivery profile to the needs of the patient.
authors.affiliation: CMUC, Department of Mathematics, University of Coimbra, 3001-454 Coimbra, Portugal ferreira@mat.uc.pt.
authors.forename: J A
authors.initials: JA
authors.lastname: Ferreira
authors.affiliation: CMUC, Department of Mathematics, University of Coimbra, 3001-454 Coimbra, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Naghipoor
authors.affiliation: CMUC, Department of Mathematics, University of Coimbra, 3001-454 Coimbra, Portugal.
authors.forename: Paula de
authors.initials: Pd
authors.lastname: Oliveira
mesh_terms: D001808:Blood Vessels; D002317:Cardiovascular Agents; D054855:Drug-Eluting Stents; D006801:Humans; D008962:Models, Theoretical
chemical_list: D002317:Cardiovascular Agents
keywords: cardiovascular drug delivery; drug-eluting stent; non-Fickian coupled model; numerical simulation