title: Strain Variation and Disease Severity in Congenital Cytomegalovirus Infection: In Search of a Viral Marker.
abstract: The wide spectrum of congenital cytomegalovirus (CMV) disease and known differences in the biology and in vitro growth of CMV strains continue to drive studies in search for specific viral genetic determinants that may predict severity of congenital CMV disease. Several CMV genes have been studied in detail in congenitally infected children, but the complexity of the viral genome and differences in the definition of symptomatic disease versus asymptomatic CMV infection continue to raise questions related to what constitutes a pathogenic CMV strain.
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: boger@jhmi.edu.
authors.forename: Ravit
authors.initials: R
authors.lastname: Arav-Boger
mesh_terms: D015415:Biomarkers; D002648:Child; D003587:Cytomegalovirus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000635:transmission / Q000821:virology*; D005814:Genes, Viral; D014644:Genetic Variation; D005838:Genotype; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D057131:Immune Evasion; D007223:Infant; D008562:Membrane Glycoproteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; C119624:UL144 ORF protein, Human herpesvirus 5; D014764:Viral Proteins
keywords: Congenital infection; Cytomegalovirus; Genotypes; Immune evasion genes; Multiple strains; Next-generation sequencing; Population-based sequencing; Strains