title: Association of metabolic syndrome with testosterone and inflammation in men.
abstract: OBJECTIVE
  There is limited data on the assessment of relationship between sex hormones, metabolic syndrome (MS) and inflammation. Therefore, our objective was to examine the relationship between metabolic syndrome, testosterone and inflammation.
  
  
  METHODS
  It was a cross-sectional study which included 309 subjects in the age range of 30-70years. Blood was analyzed for plasma glucose, serum lipids, total testosterone (TT) and high-sensitivity C-reactive protein (hs-CRP).
  
  
  RESULTS
  There were 153 patients with metabolic syndrome and 156 without MS according to modified NCEP guidelines. Age, BMI, obesity, dyslipidaemia, smoking (OR=2.35, CI=1.35-4.09), LDL-Ch, low TT (OR=0.76, CI=0.38-1.52) and elevated hs-CRP (OR=1.56, CI=0.87-2.80) were significant independent predictors of MS (all P<0.05).
  
  
  CONCLUSIONS
  The low testosterone and high hs-CRP levels are independent predictors of metabolic syndrome.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Ruhuna, P.O. Box: 70, Galle, Sri Lanka. Electronic address: chandimadhu@live.com.
authors.forename: Chandima Madhu
authors.initials: CM
authors.lastname: Wickramatilake
authors.affiliation: International Medical University, IMU Clinical School, 6 Jalan Indah, Taman Sri Kenangan 83000, Batu Pahat, Johor, Malaysia.
authors.forename: Mohamed R
authors.initials: MR
authors.lastname: Mohideen
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Ruhuna, P.O. Box: 70, Galle, Sri Lanka.
authors.forename: Chitra
authors.initials: C
authors.lastname: Pathirana
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000150:complications; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000473:pathology; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013739:Testosterone / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D013739:Testosterone; D002097:C-Reactive Protein
keywords: Hommes; Inflammation; Men; Metabolic syndrome; Syndrome métabolique; Testosterone; Testostérone