title: Evaluation of a new lateral flow test for detection of Streptococcus pneumoniae and Legionella pneumophila urinary antigen.
abstract: Pneumonia is a major cause of morbidity and mortality worldwide. Early diagnosis of the etiologic agent is important in order to choose the correct antibiotic treatment. In this study we evaluated the first commercial combined test for the agents of pneumococcal pneumonia and Legionnaires' disease based on urinary antigen detection, the ImmuView® Streptococcus pneumoniae and Legionella pneumophila Urinary Antigen Test. In this evaluation, the new test had a significantly higher sensitivity than the BinaxNOW® lateral flow tests and the Binax® EIA test. This identifies the ImmuView® S. pneumoniae and L. pneumophila Urinary Antigen Test as a fast and sensitive point of care test for identification of the infectious agent in a major group of patients with pneumonia.
authors.affiliation: Department of Microbiological Diagnostics & Virology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark. Electronic address: csv@ssi.dk.
authors.forename: Charlotte S
authors.initials: CS
authors.lastname: Jørgensen
authors.affiliation: Department of Microbiology & Infection Control, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark. Electronic address: su@ssi.dk.
authors.forename: Søren A
authors.initials: SA
authors.lastname: Uldum
authors.affiliation: Department of Production and Development, SSI Diagnostica, Herredsvejen 2, 3400 Hillerød, Denmark. Electronic address: jfd@ssi.dk.
authors.forename: Jesper F
authors.initials: JF
authors.lastname: Sørensen
authors.affiliation: Department of Production and Development, SSI Diagnostica, Herredsvejen 2, 3400 Hillerød, Denmark. Electronic address: ics@ssi.dk.
authors.forename: Ian C
authors.initials: IC
authors.lastname: Skovsted
authors.affiliation: Department of Production and Development, SSI Diagnostica, Herredsvejen 2, 3400 Hillerød, Denmark. Electronic address: sot@ssi.dk.
authors.forename: Sanne
authors.initials: S
authors.lastname: Otte
authors.affiliation: Department of Production and Development, SSI Diagnostica, Herredsvejen 2, 3400 Hillerød, Denmark. Electronic address: pel@ssi.dk.
authors.forename: Pernille L
authors.initials: PL
authors.lastname: Elverdal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000652:urine*; D005260:Female; D006801:Humans; D016952:Legionella pneumophila / Q000276:immunology* / Q000302:isolation & purification*; D007877:Legionnaires' Disease / Q000175:diagnosis; D008875:Middle Aged; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis; D000067716:Point-of-Care Testing; D011933:Reagent Kits, Diagnostic / Q000592:standards; D012680:Sensitivity and Specificity; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D000942:Antigens, Bacterial; D011933:Reagent Kits, Diagnostic
keywords: Legionella pneumophila; Pneumonia; Streptococcus pneumoniae; Urinary Antigen Test