title: The dynamic epitranscriptome: A to I editing modulates genetic information.
abstract: Adenosine to inosine editing (A to I editing) is a cotranscriptional process that contributes to transcriptome complexity by deamination of adenosines to inosines. Initially, the impact of A to I editing has been described for coding targets in the nervous system. Here, A to I editing leads to recoding and changes of single amino acids since inosine is normally interpreted as guanosine by cellular machines. However, more recently, new roles for A to I editing have emerged: Editing was shown to influence splicing and is found massively in Alu elements. Moreover, A to I editing is required to modulate innate immunity. We summarize the multiple ways in which A to I editing generates transcriptome variability and highlight recent findings in the field.
authors.affiliation: Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Dr. Bohr Gasse 9/5, A-1030, Vienna, Austria.
authors.forename: Mansoureh
authors.initials: M
authors.lastname: Tajaddod
authors.affiliation: Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Dr. Bohr Gasse 9/5, A-1030, Vienna, Austria. Michael.Jantsch@univie.ac.at.|Department of Cell Biology, Center of Cell Biology and Anatomy, Medical University of Vienna, Schwarzspanierstrasse 17, A-1090, Vienna, Austria. Michael.Jantsch@univie.ac.at.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Jantsch
authors.affiliation: Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Dr. Bohr Gasse 9/5, A-1030, Vienna, Austria. konstantin.licht@univie.ac.at.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Licht
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D003641:Deamination; D006801:Humans; D007113:Immunity, Innate; D007288:Inosine; D008322:Mammals; D017393:RNA Editing; D012326:RNA Splicing; D012333:RNA, Messenger / Q000378:metabolism*; D059467:Transcriptome / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D007288:Inosine; D000241:Adenosine