title: Epidemiology and characteristics of febrile neutropenia in oncology patients from Spanish tertiary care hospitals: PINNACLE study.
abstract: Febrile neutropenia (FN) is one of the most common adverse events associated with myelosuppressive chemotherapy for cancer treatment. The objective of this study was to describe the incidence of hospitalization due to FN in Spanish tertiary care hospitals (PINNACLE study). This epidemiological, retrospective, multicenter, nationwide study involved 119 patients from oncology units of 10 Spanish tertiary care hospitals who were admitted for FN. The primary endpoint was to assess the epidemiology and characteristics of FN. The incidence of admissions due to FN in oncology patients was 2.0% (interquartile range [IQR], 1.6-3.0). In terms of fever and absolute neutrophil count (ANC), 37.0% of the patients had a temperature of ≥38.2°C and an ANC of ≤500/m3. The number of patients who received prophylactic treatment with granulocyte colony-stimulating factor (G-CSF) was significantly higher in the palliative group (32.6%) compared with that in the non-palliative group (13.5%). The hospital length of stay was significantly shorter in patients who received prophylactic G-CSF compared with those who did not (5.0 days; IQR, 4.0-9.0 vs. 7.0 days; IQR, 5.0-11.0, respectively). The hospital length of stay was also significantly shorter in patients receiving palliative treatment (5.0 days; IQR, 3.0-7.0) compared with those receiving non-palliative therapy (7.0 days; IQR, 5.0-12.0). In conclusion, the incidence of admissions due to FN in oncology patients was 2.0% and the duration of hospital stay was 7.0 days. Prophylactic G-CSF treatment was found to be associated with better outcomes and shorter hospital stays. Therefore, the use of this treatment becomes relevant for achieving better clinical outcomes and reducing hospitalization cost in the management of FN.
authors.affiliation: University Hospital La Paz, 28046 Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: DE Castro Carpeño
authors.affiliation: Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
authors.forename: Pere
authors.initials: P
authors.lastname: Gascón-Vilaplana
authors.affiliation: University Hospital Virgen del Rocío, 41013 Seville, Spain.
authors.forename: Ana Maria Casas-Fernández-DE
authors.initials: AM
authors.lastname: Tejerina
authors.affiliation: University Hospital Miguel Servet, 50009 Zaragoza, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Antón-Torres
authors.affiliation: University Hospital Complex of Santiago, 15706 Santiago de Compostela, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: López-López
authors.affiliation: Department of Medical Oncology, Hospital of Saint Paul, 08025 Barcelona, Spain ; Department of Medicine, Autonomous University of Barcelona, 08913 Barcelona, Spain.
authors.forename: Agustí
authors.initials: A
authors.lastname: Barnadas-Molins
authors.affiliation: University Hospital of Salamanca, 37007 Salamanca, Spain.
authors.forename: Juan Jesús
authors.initials: JJ
authors.lastname: Cruz-Hernández
authors.affiliation: University General Hospital of Alicante, 03010 Alicante, Spain.
authors.forename: Bartomeu
authors.initials: B
authors.lastname: Massuti-Sureda
authors.affiliation: University General Hospital of Valencia, University of Valencia, 46014 Valencia, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Camps-Herrero
authors.affiliation: Maimónides Institute of Biomedical Research, Hospital Reina Sofía, University of Córdoba, 14004 Cordoba, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Aranda-Aguilar
authors.affiliation: Sandoz Farmacéutica SA, 28023 Madrid, Spain.
authors.forename: Francisco José Rebollo
authors.initials: FJ
authors.lastname: Laserna
keywords: PINNACLE study; Spain; cancer; chemotherapy; febrile neutropenia; hospitalization