title: [Analysis of choroidal thickness in AP-ROP, threshold disease and ROP without laser photocoagulation].
abstract: BACKGROUND
  Enhanced depth imaging (EDI) and spectral domain optical coherence tomography (SD-OCT) provide high-definition cross-sectional images of the choroid. Information on alterations in choroidal thickness (CT) after laser photocoagulation (LC) in aggressive posterior retinopathy of prematurity (APROP) and threshold disease (TD) is rare.
  
  
  METHODS
  A total of 75 eyes were retrospectively analyzed in 4 groups. Groups 1 and 2 included patients with APROP and TD, respectively, who underwent LC. Group 3 included ROP children who did not undergo LC and group 4 included full-term children. Infants aged ≥4 < 7, who had examination of subfoveal (SF) CT with SD-EDI-OCT, visual acuity (VA), spherical equivalent (SE), anterior segment and fundus examination, axial lenght (AXL) were included. The results of SFCT, VA and SE at the age of ≥ 4 < 7 years, AXL, gestational age (GA), birth weight (BW) and age at examination were compared between the groups. Potential risk factors (GA, BW, SE, AXL and SFCT) influencing visual acuity were evaluated by using multivariate linear regression analysis.
  
  
  RESULTS
  The results of SFCT and AXL were not significantly different between groups 2 and 3 or between groups 3 and 4. There was a significant difference between the other groups for SFCT and AXL and VA was significantly different between all groups. The SE was not significantly different between groups 3 and 4 but there was a significant difference for SE, BW and GA between the groups. Age at examination was not significantly different between the groups. Multivariate linear regression analysis revealed SFCT for groups 1 and 2, GA for group 3 and GA, SFCT and AXL for group 4 as independent risk factors influencing visual acuity.
  
  
  CONCLUSIONS
  The regression model used for groups 1-4 explains the variation of the dependent risk factor LogMar VA for groups 1-4 with 31.2 %, 43.5 %, 9.6 % and 69.4 %, respectively. These values expressed in percentage demonstrate that even more predictors may influence the dependent factor LogMar VA than evaluated in the study.
authors.affiliation: Faculty of Medicine, Department of Ophthalmology, Baskent University, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Gökgöz-Özisik
authors.affiliation: Faculty of Medicine, Department of Ophthalmology, Baskent University, Ankara, Turkey. retina95akk@yahoo.de.
authors.forename: Imren
authors.initials: I
authors.lastname: Akkoyun
authors.affiliation: Faculty of Medicine, Department of Ophthalmology, Baskent University, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Oto
authors.affiliation: Faculty of Medicine, Department of Ophthalmology, Baskent University, Ankara, Turkey.
authors.forename: S A
authors.initials: SA
authors.lastname: Bayar
authors.affiliation: Faculty of Medicine, Division of Neonatology, Department of Pediatrics, Baskent University, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Tarcan
authors.affiliation: Faculty of Medicine, Department of Anesthesiology and Reanimation, Baskent University, Ankara, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Kayhan
authors.affiliation: Faculty of Medicine, Department of Ophthalmology, Baskent University, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Yilmaz
mesh_terms: D002675:Child, Preschool; D002829:Choroid / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017075:Laser Coagulation / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012178:Retinopathy of Prematurity / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome
keywords: Choroid; Regression model; Risk factors; Spectral domain optical coherence tomography; Visual acuity