title: [DEXMEDETOMIDINE--THEORY OR EXPERIENCE?].
abstract: So far, the ongoing debate about the appropriateness of combining drugs with different mechanisms of analgesic action for optimal antinociceptive protection. The review deals with the theoretical calculations arguing with the physiological rationality for the inclusion of central α2-agonists in the scheme of modern multimodal analgesia. We have presented data from recent reviews regarding the efficacy and safety of intraoperative application of dexmedetomidine as a one of the latest drugs in this class.
authors.forename: P A
authors.initials: PA
authors.lastname: Volkov
authors.forename: B T
authors.initials: BT
authors.lastname: Churadze
authors.forename: S A
authors.initials: SA
authors.lastname: Sevalkin
authors.forename: Yu N
authors.initials: YN
authors.lastname: Volkova
authors.forename: V A
authors.initials: VA
authors.lastname: Guryanov
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism; D015398:Signal Transduction; D009435:Synaptic Transmission / Q000187:drug effects; D014018:Tissue Distribution
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D018712:Analgesics, Non-Narcotic; D018341:Receptors, Adrenergic, alpha-2; D020927:Dexmedetomidine