title: Recent research on bioactive xanthones from natural medicine: Garcinia hanburyi.
abstract: Garcinia hanburyi, a tropical plant found in south Asia, has a special long history in the development of both medicine and art. This review mainly focuses on the pharmacy research of the bioactive compounds from the plant in recent years. Preparative and analysis separation methods were introduced. Moreover, the chemical structure of the isolated compounds was included. The studies of biological activities of the caged xanthones from the plant, including antitumor, anti-HIV-1, antibacterial, and neurotrophic activities, were reviewed in detail. Furthermore, the mechanisms of its antitumor activity were also reviewed. As mentioned above, some of the xanthones from G. hanburyi can be promising drug candidates, which is worth studying. However, we still need much evidence to prove their efficacy and safety. So, further research is critical for the future application of xanthones from G. hanburyi.
authors.affiliation: School of Pharmacy, Anhui University of Chinese Medicine, 001 Qianjiang Road, Hefei, 230012, Anhui, China.
authors.forename: Buyun
authors.initials: B
authors.lastname: Jia
authors.forename: Shanshan
authors.initials: S
authors.lastname: Li
authors.forename: Xuerui
authors.initials: X
authors.lastname: Hu
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhu
authors.forename: Weidong
authors.initials: W
authors.lastname: Chen
mesh_terms: D000818:Animals; D019540:Area Under Curve; D045744:Cell Line, Tumor; D004347:Drug Interactions; D029760:Garcinia / Q000737:chemistry*; D006207:Half-Life; D006801:Humans; D051381:Rats; D017207:Rats, Sprague-Dawley; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D044004:Xanthones