title: Influence of chemerin rs17173608 polymorphism on polycystic ovary syndrome susceptibility.
abstract: OBJECTIVE
  The purpose of this study was to assess the association between the rs17173608 chemerin polymorphism and polycystic ovary syndrome risk (PCOS).
  
  
  METHODS
  This case-control study was performed on 150 patients with PCOS and 150 normal women as the control group. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphism.
  
  
  RESULTS
  Our finding showed a positive association between the chemerin gene rs17173608 polymorphism and risk of PCOS. In the dominant effect of the G allele (comparison between TG+GG and TT), TG+GG genotypes were associated with the risk of PCOS (odds ratio = 2; 95% confidence interval = 1.3-3.2, p = 0.003). The G allele is thus dominant and increases the risk of PCOS as compared to the T allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.5, p = 0.009). Nonetheless, there was no significant association between chemerin rs17173608 gene polymorphism and PCOS after adjusting genotypes for body mass index and age.
  
  
  CONCLUSIONS
  These results suggested that there was a significant association between chemerin rs17173608 polymorphism and the PCOS; but this relationship was affected by obesity status.
authors.affiliation: Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Movahed
authors.affiliation: Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran. Electronic address: Kohan@iaua.ac.ir.
authors.forename: Leila
authors.initials: L
authors.lastname: Kohan
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Fallahi
authors.affiliation: Department of Natural Resources, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Tabiee
mesh_terms: D000328:Adult; D000367:Age Factors; D000483:Alleles; D015992:Body Mass Index; D016022:Case-Control Studies; D018925:Chemokines / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human
keywords: chemerin; genetic obesity; polycystic ovary syndrome; polymorphism