title: Transcranial direct current stimulation (tDCS) on the dorsolateral prefrontal cortex alters P50 gating.
abstract: Transcranial direct current stimulation (tDCS) has been reported to modify cortical function by inducing alterations in the underlying brain function. P50auditory evoked potentials, as assessed using a paired auditory stimulus (S1 and S2) paradigm, are thought to reflect a sensory gating process in which the functional involvement of the dorsolateral prefrontal cortex (DLPFC) is suggested. P50 sensory gating has also been reported to be associated with the pathogenesis of psychiatric diseases such as schizophrenia and anxiety-related disorders. Here we investigated whether the tDCS over the DLPFC could modulate the cortical function leading to alteration of the P50 sensory gating. P50 gating indices (the S2/S1 ratio and S1-S2 difference) were measured during the tDCS (current 1.0 mA, duration 15 min) over the DLPFC with different conditions (anodal, cathodal and sham). Ten male healthy volunteers were studied on separate days in a single blinded paradigm. We observed that the cathodaltDCS significantly altered the mean P50 gating indices compared to the other two conditions. Our results suggest that sensory gating could be modulated by cathodaltDCS on the left DLPFC but not by anodal/sham tDCS.
authors.affiliation: Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Japan; Department of Rehabilitation, Chiba Central Medical Center, Chiba, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Terada
authors.affiliation: Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Japan; Research Center for Child Mental Development, Graduate School of Medicine, Chiba University, Japan; Tokyo Bay Rehabilitation Hospital, Chiba, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kurayama
authors.affiliation: Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Nakazawa
authors.affiliation: Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Japan; Research Center for Child Mental Development, Graduate School of Medicine, Chiba University, Japan. Electronic address: dmatsuzawa@facutlty.chiba-u.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsuzawa
authors.affiliation: Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Japan; Research Center for Child Mental Development, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D004566:Electrodes; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D055139:Sensory Gating; D065908:Transcranial Direct Current Stimulation