title: Medical treatment of prosthetic vascular graft infections: Review of the literature and proposals of a Working Group.
abstract: More than 400000 vascular grafts are inserted annually in the USA. Graft insertion is complicated by infection in 0.5-4% of cases. Vascular graft infections (VGIs) are becoming one of the most frequent prosthesis-related infections and are associated with considerable mortality, ranging from 10 to 25% within 30 days following the diagnosis. Treatment of VGI is based on urgent surgical removal of the infected graft followed by prolonged antibiotherapy. Data regarding the best antibiotherapy to use are lacking since no well designed trial to study antimicrobial treatment of VGI exists. Moreover, since VGIs demonstrate very specific pathophysiology, guidelines on other material-related infections or infective endocarditis treatment cannot be entirely applied to VGI. A French multidisciplinary group gathering infectious diseases specialists, anaesthesiologists, intensivists, microbiologists, radiologists and vascular surgeons was created to review the literature dealing with VGI and to make some proposals regarding empirical and documented antibiotic therapy for these infections. This article reveals these proposals.
authors.affiliation: Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France; CIC Inserm 1414, Rennes 1 University, Rennes, France.
authors.forename: M
authors.initials: M
authors.lastname: Revest
authors.affiliation: Intensive Care Unit, Saint-André University Hospital, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Camou
authors.affiliation: Infectious Diseases Department, Gustave Dron Hospital, Tourcoing, Lille 2 University, France.
authors.forename: E
authors.initials: E
authors.lastname: Senneville
authors.affiliation: Bacteriology Department, EA 3826 Nantes University, Hôtel Dieu University Hospital, Nantes, France.
authors.forename: J
authors.initials: J
authors.lastname: Caillon
authors.affiliation: Bacteriology Department, International Center for Infectiology Research (CIRI) - INSERM U1111, CNRS UMR5308, Lyon 1 University, ENS de Lyon, Hospices Civils de Lyon, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Laurent
authors.affiliation: Anesthesiology Department, Beziers, France.
authors.forename: B
authors.initials: B
authors.lastname: Calvet
authors.affiliation: Department of Vascular Surgery, University Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Feugier
authors.affiliation: Department of Vascular Surgery, University of Nice-Sophia Antipolis, Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: Batt
authors.affiliation: Infectious Diseases Department, University Claude Bernard Lyon 1, Hospices Civils de Lyon, Inserm U1111, Lyon 1 University, Lyon, France. Electronic address: christian.chidiac@chu-lyon.fr.
authors.forename: C
authors.initials: C
authors.lastname: Chidiac
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003646:Debridement; D005602:France; D006801:Humans; D017410:Practice Guidelines as Topic; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D058017:Vascular Grafting / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic therapy; Rifampicin; Staphylococcus; Vascular prosthesis infection