title: Interactions of Antimicrobial Peptides with Bacterial Membranes and Membrane Components.
abstract: Antimicrobial peptides (AMPs) have attracted considerable recent interest as potential therapeutics, motivated by increasing resistance development against conventional antibiotics. This brief overview summarizes some key aspects related to the interaction of AMPs with bacterial and cell membranes, as well as with membrane components, which is at the core of the mode-of-action of these compounds. Throughout, studies on peptide interactions with model lipid membranes and membrane components are correlated to biological results on antimicrobial and anti-inflammatory effects of AMPs, and translated into therapeutic considerations.
authors.forename: Martin
authors.initials: M
authors.lastname: Malmsten
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000166:cytology* / Q000187:drug effects; D002462:Cell Membrane / Q000737:chemistry* / Q000187:drug effects; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry; D008070:Lipopolysaccharides / Q000737:chemistry*; D013682:Teichoic Acids / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D008051:Lipid Bilayers; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid