title: HIV burden in men who have sex with men: a prospective cohort study 2007-2012.
abstract: We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 enrollees who were HIV-negative at enrollment and completed at least one follow-up interview, we identified 440 incident cases of HIV in the follow up period: this constituted an HIV incidence rate of 7.1 per 100 person-years (95% CI: 6.4-7.7). Early treatment of syphilis may have significantly reduced risk of HIV infection (RR: 1.45, 95% CI: 1.11-1.93), while MSM presenting perfect compliance in the cohort did not show reduction in HIV infection. Our study suggested that HIV incidence has been remained high in this sample of Chinese MSM during the intensive preventive intervention, suggesting that we need to find new strategies to prevent HIV infection in this population.
authors.affiliation: 1] National Institute of Drug Dependence, Health Science Center, Peking University Beijing 100191, China [2] Peking University Clinical Research Institute, Health Science Center, Peking University Beijing 100191, China [3] Takemi Program in International Health, Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Huang
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: School of Geography, Beijing Normal University, Beijing 100875, China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Ding
authors.affiliation: National Institute of Drug Dependence, Health Science Center, Peking University Beijing 100191, China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Feili
authors.initials: F
authors.lastname: Wei
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Caiping
authors.initials: C
authors.lastname: Guo
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Danlei
authors.initials: D
authors.lastname: Mou
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Dexi
authors.initials: D
authors.lastname: Chen
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Huiping
authors.initials: H
authors.lastname: Yan
authors.affiliation: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Chen
authors.affiliation: The Global Fund to fight AIDS, Tuberculosis and Malaria, 1214 Geneva, Switzerland.
authors.forename: Jinkou
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Aaron Diamond AIDS Research Center, New York, 10016, USA.
authors.forename: Kathrine
authors.initials: K
authors.lastname: Meyers
authors.affiliation: Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
authors.forename: Ted
authors.initials: T
authors.lastname: Cohen
authors.affiliation: The Fenway Institute, Fenway Health, Boston, MA 02118, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Mayer
authors.affiliation: Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Salomon
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Zuhong
authors.initials: Z
authors.lastname: Lu
authors.affiliation: HIV/AIDS, Tuberculosis, Malaria &Neglected Tropical Diseases, World Health Organization, 1211 Geneva 27, Switzerland.
authors.forename: Christopher
authors.initials: C
authors.lastname: Dye
mesh_terms: D000293:Adolescent; D000328:Adult; D000068476:Beijing; D060085:Coinfection / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000517:prevention & control; D018451:Homosexuality, Male; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D021841:Safe Sex; D013587:Syphilis / Q000453:epidemiology; D035862:Vulnerable Populations; D055815:Young Adult