title: Regeneration or replacement? A case report and review of literature.
abstract: Endodontic treatment of immature necrotic teeth is a real challenge. Recently, a biologically based treatment strategy, referred to as regeneration, has been introduced. Tissue regeneration requires the presence of stems cells, a scaffold, and growth factors. Endodontic regeneration may improve the prognosis of immature necrotic teeth by re-establishing the functional pulpal tissue and further development of the root. However, the tissue formed in the pulpal space may not be original pulp tissue, and in some cases, it may result in uncontrolled calcification of the pulp. This study reports a case of successful endodontic regeneration and compares this process with the normal development of the contralateral tooth. Finally, it discusses the nature of the tissue formed during endodontic regeneration.
authors.affiliation: Torabinejad Dental Research Center and Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Farhad
authors.affiliation: Endodontist, Private Practice, Isfahan, Iran.
authors.forename: Ali
authors.identifier: http://orcid.org/0000-0002-0530-8608
authors.initials: A
authors.lastname: Shokraneh
authors.affiliation: Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Shekarchizade
mesh_terms: D002648:Child; D003790:Dental Pulp Necrosis / Q000209:etiology* / Q000601:surgery*; D006801:Humans; D007180:Incisor / Q000293:injuries*; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D008297:Male; D010482:Periapical Abscess / Q000209:etiology* / Q000601:surgery*; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation; D054457:Tissue Scaffolds; D018677:Tooth Injuries / Q000150:complications* / Q000601:surgery*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: immature teeth; mineral trioxide aggregate; regenerative endodontics; root development; triple antibiotic paste