title: Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.
abstract: Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expression throughout the different subtypes of mucosal melanoma and tumor development. We detected a frequent expression of CT7 in primaries and corresponding metastases (55%) as well as for CT10 (30%). This expression resulted to be heterogeneous in the same tumor specimen and moreover influenced by the tissue of origin. Our results support the role of these antigens in immunotherapy for mucosal melanoma.
authors.affiliation: Department of Oncology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Curioni-Fontecedro
authors.affiliation: Department of Dermatology, Policlinico Umberto I, University of Rome La Sapienza, 00185 Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pitocco
authors.affiliation: Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: N L
authors.initials: NL
authors.lastname: Schoenewolf
authors.affiliation: Department of Otorhinolaryngology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Holzmann
authors.affiliation: Institute of Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Soldini
authors.affiliation: Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Dummer
authors.affiliation: Department of Dermatology, Policlinico Umberto I, University of Rome La Sapienza, 00185 Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Calvieri
authors.affiliation: Institute of Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Moch
authors.affiliation: Institute of Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Mihic-Probst
authors.affiliation: Institute of Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Fitsche
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism*; D018740:Genetic Heterogeneity; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D009092:Mucous Membrane / Q000378:metabolism* / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D000951:Antigens, Neoplasm; C110905:MAGEC1 protein, human; C405429:MAGEC2 protein, human; D009363:Neoplasm Proteins