title: Bioactive compounds from the endophytic fungus Fusarium proliferatum.
abstract: The crude extract of an endophytic fungus isolated from Syzygium cordatum and identified as Fusarium proliferatum showed 100% cytotoxicity against the brine shrimp Artemia salina at 100 μg/mL. Seven coloured, biologically active metabolites - including ergosta-5,7,22-trien-3β-ol, nectriafurone-8-methyl ether, 9-O-methyl fusarubin, bostrycoidin, bostrycoidin-9-methyl ether and 8-hydroxy-5,6-dimethoxy-2-methyl-3-(2-oxo-propyl)-1,4-naphthoquinone- were isolated from the extract.
authors.affiliation: a Department of Organic and Biomolecular Chemistry , University of Göttingen , Tammannstraße 2, D-37077 Göttingen , Germany.
authors.forename: Zerihun T
authors.initials: ZT
authors.lastname: Dame
authors.affiliation: b Department of Chemistry , University of Venda , P/Bag X5050, Thohoyandou 0950 , South Africa.
authors.forename: Beauty
authors.initials: B
authors.lastname: Silima
authors.affiliation: c Department of Plant Sciences , University of the Free State , PO Box 339, Bloemfontein 9300 , South Africa.
authors.forename: Marieka
authors.initials: M
authors.lastname: Gryzenhout
authors.affiliation: b Department of Chemistry , University of Venda , P/Bag X5050, Thohoyandou 0950 , South Africa.
authors.forename: Teunis
authors.initials: T
authors.lastname: van Ree
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects*; D003116:Color; D005670:Fusarium / Q000737:chemistry* / Q000378:metabolism; D007546:Isoquinolines / Q000302:isolation & purification; D059625:Liquid-Liquid Extraction; D009285:Naphthoquinones / Q000302:isolation & purification; D000069436:Toxicological Phenomena
chemical_list: D007546:Isoquinolines; D009285:Naphthoquinones; C060461:bostrycoidin
keywords: Endophytic fungus; Fusarium proliferatum; Syzygium cordatum; naphthoquinone