title: Classification and biology of tumour associated stromal cells.
abstract: Stroma is a fundamental component of the tumour microenvironment whereby it supports malignant cell growth and spreading. It consists of different entities including cells of the immune system, vascular structures and fibroblasts. Much attention has recently been paid to fibroblasts since there is compelling evidence that they orchestrate the recruitment of and educate other cells to promote cancer growth. This review proposes to discuss in detail the nomenclature, origin, and biological functions of the different stromal cells residing in tumours.
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, Italy. Electronic address: lizziaraffaghello@ospedale-gaslini.ge.it.
authors.forename: Lizzia
authors.initials: L
authors.lastname: Raffaghello
authors.affiliation: Regenerative & Heamatological Medicine, King's College London, UK.
authors.forename: Francesco
authors.initials: F
authors.lastname: Dazzi
mesh_terms: D002450:Cell Communication / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology / Q000473:pathology; D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000473:pathology; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000473:pathology; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology; D017154:Stromal Cells / Q000276:immunology* / Q000473:pathology; D059016:Tumor Microenvironment / Q000276:immunology*
keywords: Cancer associated fibroblasts; Fibrocytes; Mesenchymal stem cells; Tumor stroma