title: Investigations on the Flat-Detector Computed Tomography-Based CBV Map Acquisition Using a Left Ventricle Contrast Media Injection Protocol.
abstract: OBJECTIVE
  Cerebral blood volume (CBV) acquired with the use of flat-detector computed tomography with contrast media (CM) injected at the ascending aorta provides real-time brain functional information with minimized CM usage; however, unexpected asymmetric perfusion is observed for certain patients without cerebral circulatory disorders. This work tested the feasibility of left ventricle (LV) CM injection to achieve symmetric perfusion.
  
  
  METHODS
  CBV maps were acquired for 10 patients without perfusion-related cerebral abnormities. Perfusion symmetry was predicted with the use of color-coded quantitative digital subtracted angiography with CM injected at ascending aorta. Time density curves were extracted at bilateral common carotid arteries with area under curves calculated. Planes were selected on CBV maps with regions of interest defined covering characteristic regions, where asymmetric perfusion most likely to appear.
  
  
  RESULTS
  No adverse physiological changes were detected for any patient. Non-uniform CM distributions were detected for 4 patients with relative area under curves 0.66 ± 0.03, indicating asymmetric perfusion using ascending aorta injection. With LV injection, all the patients demonstrated good perfusion symmetry with relative CBV 1.03 ± 0.07.
  
  
  CONCLUSIONS
  CBV maps acquisition with LV injection offered an approach to acquire immediate brain functional information for patients who are limited by asymmetric perfusion using ascending aorta injection and are sensitive to CM dose.
authors.affiliation: Southern Medical University, Beijing, China; Beijing PLA Military General Hospital Affiliated Bayi Brain Hospital, Beijing, China.
authors.forename: Song
authors.initials: S
authors.lastname: Chaoyan
authors.affiliation: Beijing PLA Military General Hospital Affiliated Bayi Brain Hospital, Beijing, China. Electronic address: vivien-sun1226@hotmail.com.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Qiang
authors.affiliation: Siemens Ltd. China, Healthcare Sector, Beijing, China.
authors.forename: Sun
authors.initials: S
authors.lastname: Qi
authors.affiliation: Beijing PLA Military General Hospital Affiliated Bayi Brain Hospital, Beijing, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Hao
authors.affiliation: Beijing PLA Military General Hospital Affiliated Bayi Brain Hospital, Beijing, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Tonghui
authors.affiliation: Beijing PLA Military General Hospital Affiliated Bayi Brain Hospital, Beijing, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Wenlong
authors.affiliation: Beijing PLA Military General Hospital Affiliated Bayi Brain Hospital, Beijing, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Mei
authors.affiliation: Siemens Ltd. China, Healthcare Sector, Beijing, China.
authors.forename: Han
authors.initials: H
authors.lastname: Jingfeng
authors.affiliation: Siemens AG, Healthcare Sector, Angiography & Interventional X-Ray Systems, Forchheim, Germany.
authors.forename: Deuerling-Zheng
authors.initials: DZ
authors.lastname: Yu
authors.affiliation: Southern Medical University, Beijing, China; Beijing PLA Military General Hospital Affiliated Bayi Brain Hospital, Beijing, China. Electronic address: xuruxiang_bjjz@hotmail.com.
authors.forename: Xu
authors.initials: X
authors.lastname: Ruxiang
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D001810:Blood Volume; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D054893:Cone-Beam Computed Tomography; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media
keywords: Cerebral blood volume; Color-coded quantitative digital subtraction angiography; Flat-detector computed tomography; Left ventricle; Perfusion symmetry