title: Propranolol during pregnancy for large chorioangioma.
abstract: Large chorioangiomas are frequently associated with adverse perinatal outcome. Its treatment remains invasive and controversial. Infantile hemangiomas which have numerous similarities with chorioangiomas are now usually treated with propranolol. This drug has been extensively used with a good tolerance during pregnancy in other indications. We report the first use of propranolol with the aim of limiting the increase in chorioangioma volume and avoiding the associated complications. The observed inhibition of the growth of the chorioangioma after introduction of propranolol argues for further evaluation of this treatment in this indication.
authors.affiliation: Department of Pediatrics CHU (University Hospital) and CIC 1414, Rennes, France. Electronic address: patrick.pladys@chu-rennes.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Padys
authors.affiliation: Department of Pharmacy, CHU Rennes, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Fouque
authors.affiliation: Department of Pharmacy, CHU Rennes, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Le Duff
authors.affiliation: Department of Obstetrics, Clinique La Sagesse, Rennes, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: D'Hervé
authors.affiliation: Department of Obstetrics and Prenatal Diagnosis, CHU Rennes, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Poulain
mesh_terms: D000328:Adult; D005260:Female; D006391:Hemangioma / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014470:Umbilical Cord / Q000503:physiopathology; D019043:Vascular Neoplasms / Q000150:complications / Q000188:drug therapy
chemical_list: D011433:Propranolol