title: Efficacy of recombinant adenoviral human p53 gene in the treatment of lung cancer-mediated pleural effusion.
abstract: Pleural effusion induced by lung cancer exerts a negative impact on quality of life and prognosis. The aim of the present study was to evaluate the value of the recombinant adenoviral human p53 gene (rAd-p53) in the local treatment of lung cancer and its synergistic effect with chemotherapy. The present study retrospectively recruited 210 patients with lung cancer-mediated pleural effusion who had adopted a treatment strategy of platinum chemotherapy. Pleurodesis was performed via the injection of cisplatin or rAd-p53. Long-term follow-up was conducted to investigate the therapeutic effects of cisplatin and rAd-p53 administration on pleural effusion and other relevant clinical indicators. The short-term effect of pleurodesis was as follows: The efficacy rate of rAd-p53 therapy was significantly higher compared with cisplatin therapy (71.26 vs. 54.47%), and the efficacy of treatment with ≥2×1012 viral particles of rAd-p53 for pleurodesis was significantly greater than treatment with 40 mg cisplatin (P<0.05). Furthermore, efficacy analysis performed 6 and 12 months after pleurodesis indicated that the efficacy rate of rAd-p53 was significantly greater than that of cisplatin (P<0.05). A comparison of median progression-free survival (PFS) time identified a significant difference (P<0.05) between rAd-p53 and cisplatin therapy (3.3 vs. 2.7 months); however, a comparison of median overall survival time identified no significant difference (P>0.05) between rAd-p53 and cisplatin therapy (9.6 vs. 8.7 months). In addition, Cox regression analysis indicated that PFS was not affected by clinical indicators such as age, gender, prognostic staging and smoking status; however, PFS was affected by pathological subtype (adenocarcinoma or squamous carcinoma) in the rAd-p53 group. rAd-p53 administration for pleurodesis exerts long-term therapeutic effects on the local treatment of lung cancer. Thus, a combination of rAd-p53 and chemotherapy may exert a synergistic effect and reverse multidrug resistance.
authors.affiliation: Department of Respiration, Daping Hospital, Third Military Medical University, Yuzhong, Chongqing 400042, P.R. China.
authors.forename: Kun-Lin
authors.initials: KL
authors.lastname: Li
authors.affiliation: Department of Respiration, Daping Hospital, Third Military Medical University, Yuzhong, Chongqing 400042, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Kang
authors.affiliation: College of Interpreting and Translation, Sichuan International Studies University, Shapingba, Chongqing 400031, P.R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Respiration, Daping Hospital, Third Military Medical University, Yuzhong, Chongqing 400042, P.R. China.
authors.forename: L I
authors.initials: LI
authors.lastname: Li
authors.affiliation: Department of Respiration, Daping Hospital, Third Military Medical University, Yuzhong, Chongqing 400042, P.R. China.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Wang
authors.affiliation: Department of Respiration, Daping Hospital, Third Military Medical University, Yuzhong, Chongqing 400042, P.R. China.
authors.forename: Heng-Yi
authors.initials: HY
authors.lastname: Chen
authors.affiliation: Department of Respiration, Daping Hospital, Third Military Medical University, Yuzhong, Chongqing 400042, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: He
keywords: lung cancer; malignant pleural effusion; pleurodesis