title: Secondary Metabolites Isolated from the Amazonian Endophytic Fungus Diaporthe sp. SNB-GSS10.
abstract: We describe a Sabicea cinerea endophytic fungus closely related to Diaporthe pseudomangiferae that produces two known metabolites, mycoepoxydiene (1) and altiloxin A (2), as well as enamidin (3) and eremofortin F (4), two compounds not previously described in the literature. The structure of these four metabolites was elucidated using spectroscopic analysis, and their cytotoxic activities were measured against the human cell lines KB, MRC-5, and MDA-MB-435.
authors.affiliation: †CNRS-Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Mandavid
authors.affiliation: †CNRS-Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France.
authors.forename: Alice M S
authors.initials: AM
authors.lastname: Rodrigues
authors.affiliation: ‡Laboratório de Farmacognosia, Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Laila S
authors.initials: LS
authors.lastname: Espindola
authors.affiliation: †CNRS-Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Eparvier
authors.affiliation: †CNRS-Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France.|§UPMC Univ Paris 06, CNRS, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Sorbonne Universités, Observatoire Océanologique, 66650 Banyuls-sur-Mer, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Stien
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D011753:Pyrones; D012717:Sesquiterpenes; C000602217:altiloxin A; C476085:mycoepoxydiene