title: Management of IBD in the Elderly Patient With Cancer.
abstract: The management of inflammatory bowel disease (IBD) in patients with known or recently treated cancer has become a common dilemma in our ageing population. Older patients are commonly excluded from prospective trials, and co-morbid status and polypharmacy may muddy our understanding of the impact of therapies on these patients. Immunosuppression (anti-TNF therapy, antimetabolite therapy) carries a relative contra-indication in the setting of known cancer as it is expected to increase cancer risk and increase propagation of in situ cancer. Recent studies have sought to investigate this risk by looking from two sides-the impact of cancer therapies on IBD outcomes and the risk of cancer occurrence/recurrence in patients on IBD therapies. In this chapter, we review this data and determine the safety of commonly used IBD therapies in this potentially vulnerable elderly population.
authors.affiliation: Inflammatory Bowel Disease Program, Columbia University Medical Center, 161 Fort Washington Ave, Suite 862, New York, NY, 10032, USA, gl2501@cumc.columbia.edu.
authors.forename: Garrett
authors.initials: G
authors.lastname: Lawlor
authors.forename: Seymour
authors.initials: S
authors.lastname: Katz