title: Transient receptor potential channel superfamily: Role in lower urinary tract function.
abstract: Lower urinary tract symptoms associated with neurogenic bladder and overactive bladder syndrome are mediated in part by members of the transient receptor potential channel superfamily. The best studied member of this superfamily is the vanilloid receptor. Other transient receptor potential channels, such as the melastatin receptor and the ankyrin receptor, are also active in the pathogenesis of lower urinary tract dysfunction. However, the detailed mechanisms by which the transient receptor potential channels contribute to lower urinary tract symptoms are still not clear, and the therapeutic benefits of modulating transient receptor potential channel activity have not been proved in the clinical setting. In the present review, to better understand the pathophysiology and therapeutic potential for lower urinary tract symptoms, we summarize the presence and role of different members of the transient receptor potential channel superfamily in the lower urinary tract.
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Imamura
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Nakazawa
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Hiragata
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagai
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Minagawa
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yokoyama
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Masakuni
authors.initials: M
authors.lastname: Ishikawa
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Domen
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishizuka
mesh_terms: D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000503:physiopathology*; D050051:Transient Receptor Potential Channels / Q000502:physiology*; D001743:Urinary Bladder / Q000503:physiopathology*; D001750:Urinary Bladder, Neurogenic / Q000503:physiopathology*; D014553:Urinary Tract Physiological Phenomena
chemical_list: D050051:Transient Receptor Potential Channels
keywords: bladder; lower urinary tract; transient receptor potential