title: Spatial learning in men undergoing alcohol detoxification.
abstract: Alcohol dependence is a major public health problem worldwide. Brain and behavioral disruptions including changes in cognitive abilities are common features of alcohol addiction. Thus, the present study was aimed to investigate spatial learning and memory in 29 alcoholic men undergoing alcohol detoxification by using a virtual Morris maze task. As age-matched controls we recruited 29 men among occasional drinkers without history of alcohol dependence and/or alcohol related diseases and with a negative blood alcohol level at the time of testing. We found that the responses to the virtual Morris maze are impaired in men undergoing alcohol detoxification. Notably they showed increased latencies in the first movement during the trials, increased latencies in retrieving the hidden platform and increased latencies in reaching the visible platform. These findings were associated with reduced swimming time in the target quadrant of the pool where the platform had been during the 4 hidden platform trials of the learning phase compared to controls. Such increasing latency responses may suggest motor control, attentional and motivational deficits due to alcohol detoxification.
authors.affiliation: Center for Alcohol Abuse (Centro Riferimento Alcologico Regione Lazio-CRARL), Department of Clinical Medicine, Sapienza University of Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Ceccanti
authors.affiliation: University of New Mexico, Albuquerque, NM, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Hamilton
authors.affiliation: Center for Alcohol Abuse (Centro Riferimento Alcologico Regione Lazio-CRARL), Department of Clinical Medicine, Sapienza University of Rome, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Coriale
authors.affiliation: Institute of Cell Biology and Neurobiology, National Research Council (IBCN-CNR), Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Carito
authors.affiliation: Institute of Cell Biology and Neurobiology, National Research Council (IBCN-CNR), Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Aloe
authors.affiliation: Division of Cell Biology, Medical University, BG-9002 Varna, Bulgaria.
authors.forename: George
authors.initials: G
authors.lastname: Chaldakov
authors.affiliation: Center for Alcohol Abuse (Centro Riferimento Alcologico Regione Lazio-CRARL), Department of Clinical Medicine, Sapienza University of Rome, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Romeo
authors.affiliation: Division of Cell Biology, Medical University, BG-9002 Varna, Bulgaria.
authors.forename: Marco
authors.initials: M
authors.lastname: Ceccanti
authors.affiliation: Department of Health Sciences, University of L'Aquila, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Iannitelli
authors.affiliation: Institute of Cell Biology and Neurobiology, National Research Council (IBCN-CNR), Rome, Italy. Electronic address: marco.fiore@cnr.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Fiore
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000503:physiopathology* / Q000628:therapy*; D000704:Analysis of Variance; D016022:Case-Control Studies; D006801:Humans; D007859:Learning Disabilities / Q000209:etiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000502:physiology; D065853:Spatial Learning / Q000502:physiology*; D014584:User-Computer Interface
keywords: Ethanol detoxification; Virtual Morris maze