title: The Pharmacological Effects of Benachio-F(®) on Rat Gastrointestinal Functions.
abstract: Functional dyspepsia (FD) is a prevalent idiopathic upper gastrointestinal (GI) disorder characterized by diverse symptomatology including epigastric pain or discomfort, postprandial fullness, and early satiety. Although its pathophysiological mechanisms have not yet been fully established, the available studies suggest that the etiology of FD is invariably multifactorial. Benachio-F(®) (BF) is a proprietary liquid formulation of 7 herbal extracts that has been proposed to address this multifactorial etiology using multi-drug phytotherapy. The pharmacological effects of BF, in comparison with those of two other herbal products (Whalmyungsu(®); WM and Iberogast(®); IB) were evaluated in rats. In a laparotomy-induced rat model of delayed GI transit, BF significantly accelerated the delayed gastric emptying caused by morphine, apomorphine, and cisplatin, and also significantly increased mean gastric transit, as compared to the control animals. BF markedly increased gastric accommodation in rats and produced higher gastric volume values than did the control treatment. The effects of BF were generally comparable or superior to those of WM and IB in these models. Furthermore, BF significantly stimulated biliary flow, as compared to the control treatment. These results indicated that BF might have great potential as an effective phytotherapeutic agent capable of reducing GI symptoms and increasing quality of life in FD patients.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan 712-749.
authors.forename: Bijay Kumar
authors.initials: BK
authors.lastname: Poudel
authors.affiliation: Dong-A Pharmaceutical Co. Ltd., Yongin 449-905.
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Yu
authors.affiliation: Dong-A Pharmaceutical Co. Ltd., Yongin 449-905.
authors.forename: Yong Sam
authors.initials: YS
authors.lastname: Kwon
authors.affiliation: Dong-A Pharmaceutical Co. Ltd., Yongin 449-905.
authors.forename: Hyoung Geun
authors.initials: HG
authors.lastname: Park
authors.affiliation: Dong-A Pharmaceutical Co. Ltd., Yongin 449-905.
authors.forename: Miwon
authors.initials: M
authors.lastname: Son
authors.affiliation: Dong-A Pharmaceutical Co. Ltd., Yongin 449-905.
authors.forename: Joon Ho
authors.initials: JH
authors.lastname: Jun
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan 712-749.
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
keywords: Benachio-F®; Bile secretion; Functional dyspepsia; Gastric accommodation; Gastric emptying; Gastric transit