title: Japanese nationwide surveillance in 2011 of antibacterial susceptibility patterns of clinical isolates from complicated urinary tract infection cases.
abstract: To investigate antimicrobial susceptibility patterns of various bacterial pathogens isolated from complicated urinary tract infection (UTI) cases, the Japanese Society of Chemotherapy, the Japanese Association of Infectious Disease, and the Japanese Society of Clinical Microbiology conducted the second nationwide surveillance from January to September 2011. With the cooperation of 42 medical institutions throughout Japan, 1036 strains belonging to 8 clinically relevant bacterial species were collected. Among methicillin-resistant Staphylococcus aureus (MRSA) strain, the vancomycin (VCM) MIC for 5.5% (3/55) of the strains was 2 μg/mL. Ampicillin, VCM, and linezolid were relatively active against 209 Enterococcus faecalis strains. The proportion of fluoroquinolone (FQ)-resistant strains was >20%. The MIC90 of FQs against the 382 Escherichia coli strains was 2-64 mg/L and the proportion resistant to FQs was approximately 30%. However, susceptibility of E. coli to sitafloxacin was still high (MIC90 = 2 mg/L). Fifty-eight (15.2%) of 382 E. coli, 6 (4.5%) of 132 Klebsiella pneumoniae, 1 (2.4%) of 41 Klebsiella oxytoca and 4 (6.8%) of 59 Proteus mirabilis strains were suspected of producing extended-spectrum beta-lactamase. Of 93 Pseudomonas aeruginosa strains, the proportions resistant to imipenem, amikacin, and ciprofloxacin were 21.5%, 4.3%, and 20.4%, respectively. Four strains (4.3%) were found to be multidrug-resistant. In complicated UTI cases, all of MRSA and E. faecalis were susceptible to all anti-MRSA agents. Sitafloxacin was active against other FQ-resistant E. coli strains. The isolation of extended-spectrum beta-lactamase-producing and multidrug-resistant strains increased.
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Urology, Fujita Health University School of Medicine, Aichi, Japan. Electronic address: kiyo@fujita-hu.ac.jp.
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Ishikawa
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Urology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Hamasuna
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Uehara
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Yasuda
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Urology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Blood Purification Center, Kagoshima University Hospital, Kagoshima, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayami
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Urology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Minamitani
authors.affiliation: The Surveillance Committee of JSC, JAID and JSCM, Tokyo, Japan.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kadota
authors.affiliation: The Surveillance Committee of JSC, JAID and JSCM, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwata
authors.affiliation: The Surveillance Committee of JSC, JAID and JSCM, Tokyo, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kaku
authors.affiliation: The Surveillance Committee of JSC, JAID and JSCM, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.affiliation: The Surveillance Committee of JSC, JAID and JSCM, Tokyo, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
authors.affiliation: The Surveillance Committee of JSC, JAID and JSCM, Tokyo, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.affiliation: Research Center for Anti-infectious Drugs, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hanaki
authors.affiliation: Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
authors.affiliation: Department of Urology, The Jikei University Katsushika Medical Center, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyota
authors.affiliation: Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Egawa
authors.affiliation: Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Deguchi
authors.affiliation: Division of Urology, Kobe University Graduate School of Medicine, Hyogo, Japan.
authors.forename: Minori
authors.initials: M
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authors.affiliation: Division of Urology, Kobe University Graduate School of Medicine, Hyogo, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Division of Urology, Kobe University Graduate School of Medicine, Hyogo, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Arakawa
authors.affiliation: Division of Urology, Kobe University Graduate School of Medicine, Hyogo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
authors.affiliation: Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumon
authors.affiliation: Department of Urology, Institute of Biomedical & Health Sciences Hiroshima University, Hiroshima, Japan.
authors.forename: Kanao
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Department of Urology, Institute of Biomedical & Health Sciences Hiroshima University, Hiroshima, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Matsubara
authors.affiliation: Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Wakeda
authors.affiliation: Department of Urology, Minami Medical Health Cooperation, Aichi, Japan.
authors.forename: Yoshinosuke
authors.initials: Y
authors.lastname: Amemoto
authors.affiliation: Department of Urology, Fuji City General Hospital, Shizuoka, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Onodera
authors.affiliation: Department of Urology, Fuji City General Hospital, Shizuoka, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Goto
authors.affiliation: Department of Urology, Gifu Municipal Hospital, Gifu, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Komeda
authors.affiliation: Department of Urology, Shinko Hospital, Hyogo, Japan.
authors.forename: Masuo
authors.initials: M
authors.lastname: Yamashita
authors.affiliation: Department of Urology, Japanese Red Cross Okayama Hospital, Okayama, Japan.
authors.forename: Tadasu
authors.initials: T
authors.lastname: Takenaka
authors.affiliation: Department of Urology, Ogaki Municipal Hospital, Gifu, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimoto
authors.affiliation: Department of Urology, Okayama City Hospital, Okayama, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Tsugawa
authors.affiliation: Department of Urology, Gifu Prefectural General Medical Center, Gifu, Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Department of Urology, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maeda
authors.affiliation: Department of Urology, Shiga Medical Center for Adults, Shiga, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Onishi
authors.affiliation: Department of Urology, Shiga Medical Center for Adults, Shiga, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishitoya
authors.affiliation: Department of Urology, Osaka Red Cross Hospital, Osaka, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nishimura
authors.affiliation: Department of Urology, Osaka Red Cross Hospital, Osaka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Mitsumori
authors.affiliation: Department of Urology, Nagoya Ekisaikai Hospital, Aichi, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Urology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Togo
authors.affiliation: Department of Urology, Kobe City Medical Center West Hospital, Hyogo, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakamura
authors.affiliation: Department of Urology, Nishi Kobe Medical Center, Hyogo, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ito
authors.affiliation: Department of Urology, Nishi Kobe Medical Center, Hyogo, Japan.
authors.forename: Sojun
authors.initials: S
authors.lastname: Kanamaru
authors.affiliation: Department of Urology, Japan Community Health Care Organization Hokkaido Hospital, Hokkaido, Japan.
authors.forename: Takaoki
authors.initials: T
authors.lastname: Hirose
authors.affiliation: Department of Urology, Japan Community Health Care Organization Hokkaido Hospital, Hokkaido, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Muranaka
authors.affiliation: Department of Urology, Mitoyo General Hospital, Kagawa, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamada
authors.affiliation: Department of Urology, Kizawa Memorial Hospital, Gifu, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishihara
authors.affiliation: Department of Urology, Nara Social Insurance Hospital, Nara, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Oka
authors.affiliation: Department of Urology, Munakata Suikokai General Hospital, Fukutsu, Japan.
authors.forename: Hisato
authors.initials: H
authors.lastname: Inatomi
authors.affiliation: Department of Urology, Japanese Red Cross Kobe Hospital, Hyogo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsui
authors.affiliation: Department of Urology, National Hospital Organization Iwakuni Clinical Center, Yamaguchi, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobuke
authors.affiliation: Department of Urology, Hokkaido Social Work Association Obihiro Hospital, Hokkaido, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Kunishima
authors.affiliation: Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
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authors.affiliation: Department of Urology, Tottori Municipal Hospital, Tottori, Japan.
authors.forename: Takaharu
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authors.affiliation: Department of Urology, Kagoshima Prefectural Ohshima Hospital, Kagoshima, Japan.
authors.forename: Ichiro
authors.initials: I
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authors.affiliation: Department of Urology, Takikawa Municipal Hospital, Hokkaido, Japan.
authors.forename: Masanori
authors.initials: M
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authors.affiliation: Department of Urology, Fukuoka Shin Mizumaki Hospital, Fukuoka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Urology, Hiroshima City Asa Hospital, Hiroshima, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Mita
authors.affiliation: Department of Urology, Hiroshima City Asa Hospital, Hiroshima, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Kato
authors.affiliation: Department of Urology, Tenri Hospital, Nara, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okumura
authors.affiliation: Department of Urology, Tenri Hospital, Nara, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawanishi
authors.affiliation: Department of Urology, Kansai Electric Power Hospital, Osaka, Japan.
authors.forename: Takayuki
authors.initials: T
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authors.affiliation: Department of Urology, Kansai Electric Power Hospital, Osaka, Japan.
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Aoyama
authors.affiliation: Department of Urology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Shigeta
authors.affiliation: Department of Urology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Koda
authors.affiliation: Department of Urology, Oji General Hospital, Hokkaido, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Taguchi
authors.affiliation: Department of Urology, Oji General Hospital, Hokkaido, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Matsuda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000583:Amikacin / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D007564:Japan; D041121:Klebsiella oxytoca / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D000069349:Linezolid / Q000494:pharmacology; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011159:Population Surveillance; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D014552:Urinary Tract Infections / Q000382:microbiology*; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D014640:Vancomycin; D015378:Imipenem; D000667:Ampicillin; D000583:Amikacin; C076246:sitafloxacin; D000069349:Linezolid
keywords: Complicated urinary tract infection; Surveillance; Susceptibility