title: Subcutaneous panniculitis-like T-cell lymphoma: Pediatric case series demonstrating heterogeneous presentation and option for watchful waiting.
abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and primary cutaneous gamma delta T-cell lymphoma (PCGD-TCL) were initially both classified as subcutaneous panniculitis-like T-cell lymphoma. In 2008, SPTCL with alpha-beta T-cell receptor subtype was separated from primary cutaneous gamma delta T-cell lymphomas (PCGD-TCL). We report four pediatric cases that demonstrate the heterogeneity of each disease and show that PCGD-TCL in children can have an indolent course, whereas SPTCL can behave aggressively. Three patients had spontaneous, durable remissions without treatment, whereas the one patient with disease progression was treated successfully. Watchful waiting may thus be appropriate for initial management of children.
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
authors.forename: Emily E
authors.initials: EE
authors.lastname: Johnston
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California.
authors.forename: Robert E
authors.initials: RE
authors.lastname: LeBlanc
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California.|Department of Dermatology, Stanford University School of Medicine, Stanford, California.
authors.forename: Jinah
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, University of California Davis, Sacramento, California.
authors.forename: Jong
authors.initials: J
authors.lastname: Chung
authors.affiliation: Department of Pediatrics, University of California Davis, Sacramento, California.
authors.forename: Jay
authors.initials: J
authors.lastname: Balagtas
authors.affiliation: Department of Dermatology, Stanford University School of Medicine, Stanford, California.
authors.forename: Youn H
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Link
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D018205:Neoplasms, Adipose Tissue / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D015434:Panniculitis
keywords: lymphoma; medical oncology; non-Hodgkin lymphoma; oncology; pediatric hematology/oncology; subcutaneous panniculitis-like T-Cell lymphoma