title: MVsCarta: A protein database of matrix vesicles to aid understanding of biomineralization.
abstract: Matrix vesicles (MVs) are membranous nanovesicles released by chondrocytes, osteoblasts, and odontoblasts. They play a critical role in modulating mineralization. Here, we present a manually curated database of MV proteins, namely MVsCara to provide comprehensive information on MVs of protein components. In the current version, the database contains 2,713 proteins of six organisms identified in bone, cartilage, tooth tissues, and cells capable of producing a mineralized bone matrix. The MVsCarta database is now freely assessed at http://bioinf.xmu.edu.cn/MVsCarta. The search and browse methods were developed for better retrieval of data. In addition, bioinformatic tools like Gene Ontology (GO) analysis, network visualization and protein-protein interaction analysis were implemented for a functional understanding of MVs components. Similar database hasn't been reported yet. We believe that this free web-based database might serve as a useful repository to elucidate the novel function and regulation of MVs during mineralization, and to stimulate the advancement of MV studies.
authors.affiliation: Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Key Laboratory for Biotech-Drugs Ministry of Health.
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Cui
authors.forename: Quan
authors.initials: Q
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Luan
authors.forename: Shichang
authors.initials: S
authors.lastname: Hu
authors.forename: Jianbo
authors.initials: J
authors.lastname: Pan
authors.forename: Jinxiang
authors.initials: J
authors.lastname: Han
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Ji
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002113:Calcification, Physiologic; D002356:Cartilage / Q000378:metabolism; D002417:Cattle; D002645:Chickens; D019902:Chondrocytes / Q000378:metabolism; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D051379:Mice; D010006:Osteoblasts / Q000378:metabolism; D025941:Protein Interaction Mapping; D040901:Proteomics / Q000379:methods; D011817:Rabbits; D051381:Rats; D014070:Tooth / Q000378:metabolism