title: Imaging Potential and Biodistribution in vivo of 2-[18F]Fluoropropionic Acid in Breast Cancer-bearing Mice.
abstract: To investigate the imaging potential and biodistribution in vivo of a novel positron imaging agent,2-[(18)F]fluoropropionic,in breast cancer-bearing mice. Methods: 2-[(18)F]fluoropropionic acid (7.4-11.1 MBq)was injected into the breast cancer-bearing mice via tail vein,followed by micro positron emission tomography at 60 min and 120 min.The radioactivity per volume (Bq/ml) in organs was transferred to percentage injected dose per gram(% ID/g)by Inveon Research software and the biodistribution of 2-[(18)F]fluoropropionic acid in organs was deduce.The same operations were done with (18)F-FDG.
  
  
  
  2-[(18)F]fluoropropionic acid was mainly distributed in the urinary bladder,intestine,and liver between 60 min to 120 min.The breast cancer at right flank was visualized clearly,and the radioactivity uptake was (13.74±1.97)% ID/g and (14.84±1.06)% ID/g,respectively,at these two time points (P=0.454).The radioactivity uptakes in muscle and brown tissue were relatively low.The radioactivity uptake of (18)F-FDG was (10.27±2.34)% ID/g at the breast cancer 60 min after injection,and radioactivity uptake of the brown fat on the back was obvious.
  
  
  
  Positron imaging agent 2-[(18)F]fluoropropionic acid can be used to image breast cancer.It may be applied in the noninvasive imaging of breast cancer in clinical settings.
authors.affiliation: Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Dang
authors.affiliation: Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
mesh_terms: D000818:Animals; D001943:Breast Neoplasms; D019788:Fluorodeoxyglucose F18; D051379:Mice; D049268:Positron-Emission Tomography; D014018:Tissue Distribution
chemical_list: D019788:Fluorodeoxyglucose F18