title: Association between variant amyloid deposits and motor deficits in FAD-associated presenilin-1 mutations: A systematic review.
abstract: BACKGROUND
  The variant amyloid deposits (VAD) include cotton wool plaques and diffuse plaques, which are associated with various motor deficits (e.g. spastic paraparesis, myoclonus, parkinsonism and ataxia). VADs have been repeatedly identified in presenilin 1 (PSEN1) mutations. It is still unknown the effect of VAD on the motor deficits as well as on the course of Alzheimer's disease (AD).
  
  
  METHODS
  We conducted a systematic review of the literature using MEDLINE, AD&FTDMDB and China National Knowledge Infrastructure database.
  
  
  RESULTS
  A total of 46 studies on 84 patients were included. We found that the odds ratio of the motor deficits in the VAD group (56 patients) was 4.231 times of the non-VAD group (28 patients). Moreover, VAD group displayed older age of onset (42.80±9.12 years) and longer duration (9.05±4.75 years) of the diseases.
  
  
  CONCLUSIONS
  These results suggested that the VADs might be associated with the increased occurrence of the motor deficits. Moreover, the VADs might act as a protective modifier of the disease course of AD.
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, PR China.
authors.forename: Shuting
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, PR China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Lei
authors.affiliation: Department of Emergency, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Duke-Nus Graduate Medical School Singapore, 169857 Singapore, Singapore.
authors.forename: Mingming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, PR China.
authors.forename: Wendan
authors.initials: W
authors.lastname: Tao
authors.affiliation: Department of Neurology, The Second Clinical Medical College & Nanchong Center Hospital, North Sichuan Medical College, No. 97 South Renmin Road, Nanchong 637000, Sichuan Province, PR China. Electronic address: hxliumedidoctor@163.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, PR China. Electronic address: wyplmh@hotmail.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics*; D016208:Databases, Factual / Q000706:statistics & numerical data; D006801:Humans; D009069:Movement Disorders / Q000209:etiology / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D058225:Plaque, Amyloid / Q000378:metabolism*; D053764:Presenilin-1 / Q000235:genetics*
chemical_list: D053764:Presenilin-1
keywords: Amyloid plaques; CPW; Cotton wool plaques; Diffuse plaques; Familial Alzheimer's disease; Motor deficits; Presenilin 1; Spastic paraparesis; Systematic review; Variant AD; Variant amyloid deposits