title: Effect of TiO2 nanotubes arrays on osseointegration of orthodontic miniscrew.
abstract: To increase the stability of orthodontic miniscrews, TiO2 nanotube arrays were fabricated on the surface of Ti miniscrews and the effect of those arrays on the osseointegration of miniscrews was evaluated. Highly ordered TiO2 nanotube arrays were grown on the surface of orthodontic miniscrews. Ethylene glycol based electrolyte was used in the anodic oxidation process. Two-step anodic oxidation was conducted to obtain clean and open windows in TiO2 nanotube arrays. The diameter and length of the TiO2 nanotube arrays were ~ 70 nm and ~ 5 μm, respectively. The miniscrews with TiO2 nanotube arrays were implanted in the legs of New Zealand white rabbits for 8 weeks. Histological osseointegration was assessed by bone-to-implant contact ratio, and three-dimensional bone volume ratio was measured by micro-computed tomography analysis. The miniscrews with TiO2 nanotube arrays had a greater mean bone-to-implant contact ratio of 52.8 % than the control, 29.3 %. Mean bone volume ratio (BV/TV) was also higher in the miniscrews with TiO2 nanotube arrays, at 81.2 % than those in the control via micro-CT analysis. Our findings support that TiO2 nanotube arrays on the surface of miniscrews enhance osseointegration and improve the stability of the miniscrew.
authors.affiliation: Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, Gangneung, 210-720, South Korea.
authors.forename: Insan
authors.initials: I
authors.lastname: Jang
authors.forename: Seong-Cheol
authors.initials: SC
authors.lastname: Shim
authors.forename: Dong-Soon
authors.initials: DS
authors.lastname: Choi
authors.forename: Bong-Kuen
authors.initials: BK
authors.lastname: Cha
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Lee
authors.forename: Byung-Hak
authors.initials: BH
authors.lastname: Choe
authors.forename: Won-Youl
authors.initials: WY
authors.lastname: Choi
mesh_terms: D000818:Animals; D001863:Bone Screws; D005260:Female; D046228:Microarray Analysis; D043942:Nanotubes / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects*; D019736:Prostheses and Implants; D011817:Rabbits; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D055114:X-Ray Microtomography
chemical_list: C009495:titanium dioxide; D014025:Titanium