title: Biodegradable poly(vinyl alcohol)/polyoxalate electrospun nanofibers for hydrogen peroxide-triggered drug release.
abstract: Release of drugs in a controlled and sustainable manner is of great interest for treating some inflammatory diseases, drug delivery, and cosmetics. In this work, we demonstrated the control release of a drug from composite nanofibers mediated by hydrogen peroxide. Composite nanofibers of polyvinyl alcohol (PVA)/polyoxalate (PVA/POX NFs) blended at various weight ratios were successfully prepared by electrospinning. Rhodamine B (RB) was used as a model of drug and was initially loaded into the POX portion. The morphology of NFs was characterized using scanning electron microscopy (SEM). The functional groups presented in the NFs were characterized using IR spectroscopy. In vitro release behavior and cell toxicity of nanofibers were also investigated using the MTT assay. The results indicated that POX content had a significant effect on the size and release profiles of nanofibers. Microstructure analysis revealed that sizes of PVA/POX NFs increased with increasing POX content, ranging from 214 to 422 nm. Release profiles of RB at 37 °C were non-linear and showed different release mechanisms. The mechanism of drug release depended on the chemical composition of the NFs. RB release from the NFs with highest POX content was caused by the degradation of the nanofiber matrix, whereas the RB release in lower POX content NFs was caused by diffusion. The NFs with POX showed a loss of structural integrity in the presence of hydrogen peroxide as seen using SEM. The MTT assay showed that composite nanofibers had minimal cytotoxicity. We anticipate that nanofibrous PVA/POX can potentially be used to target numerous inflammatory diseases that overproduce hydrogen peroxide and may become a potential candidate for use as a local drug delivery vehicle.
authors.affiliation: a Materials Science and Nanotechnology Program, Faculty of Science , Khon Kaen University , Khon Kaen 40002 , Thailand.
authors.forename: Nutthakritta
authors.initials: N
authors.lastname: Phromviyo
authors.forename: Aurachat
authors.initials: A
authors.lastname: Lert-Itthiporn
authors.forename: Ekaphan
authors.initials: E
authors.lastname: Swatsitang
authors.forename: Apiwat
authors.initials: A
authors.lastname: Chompoosor
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000502:physiology; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000493:pharmacokinetics; D006861:Hydrogen Peroxide / Q000737:chemistry; D007700:Kinetics; D008264:Macrophages / Q000502:physiology; D008422:Materials Testing; D051379:Mice; D064347:Microscopy, Electrochemical, Scanning; D008958:Models, Molecular; D057139:Nanofibers / Q000737:chemistry; D017711:Nonlinear Dynamics; D010070:Oxalates / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012235:Rhodamines / Q000008:administration & dosage / Q000493:pharmacokinetics; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D005456:Fluorescent Dyes; D010070:Oxalates; D012235:Rhodamines; D011142:Polyvinyl Alcohol; D006861:Hydrogen Peroxide; C029773:rhodamine B
keywords: anti-inflammatory; drug release; electrospun nanofibers; hydrogen peroxide responsive; polyoxalate