title: Pediatric Semicircular Canal Dehiscence: Radiographic and Histologic Prevalence, With Clinical Correlation.
abstract: OBJECTIVE
  To determine the prevalence of radiographic and histologic superior semicircular canal dehiscence (SSCD) and posterior semicircular canal dehiscence (PSCD) and associated changes in temporal bone thickness in children aged 0 to 7 years.
  
  
  METHODS
  Retrospective chart review and histopathologic review of cadaveric bone specimens.
  
  
  METHODS
  Two tertiary referral centers.
  
  
  METHODS
  Children younger than 7 years who underwent high-resolution computed tomography scan including the temporal bones between 1998 and 2013 and temporal bones harvested from children younger than 7 years.
  
  
  METHODS
  Two hundred twenty-eight computed tomography studies and 58 temporal bone specimens were reviewed. Available patient demographics were tabulated.
  
  
  METHODS
  Prevalence of SSCD and PSCD and bone thickness over semicircular canals, with comparison across age groups. Clinical data were extracted for patients with radiographic dehiscence.
  
  
  RESULTS
  Prevalence by ear of SSCD was 11.9%, 4.9%, 2.8%, and 0% and of PSCD was 16.7%, 2.4%, 1.4%, and 0% in children aged less than 6 months, 6 to 11 months, 12 to 35 months, and 3 to 7 years, respectively. SSCD was statistically more common before 1 year of age and PSCD before 6 months of age. Bone thickness overlying both the SSC and the PSC increased with age. Radiographic PSC bone was significantly thicker than SSC bone in patients older than 12 months. No dehiscences were found in the histologic specimens.
  
  
  CONCLUSIONS
  Radiographic dehiscence of the canals is common in the first 6 months of life, with thin bone seen histologically. Prevalence decreases with increasing age as the bone overlying the canals increases in thickness.
authors.affiliation: *Stanford University Medical Center, Palo Alto, California; †Brigham and Women's Hospital, Boston, Massachusetts; ‡The Johns Hopkins University Hospital, Baltimore, Maryland; and §Lucile Salter Packard Children's Hospital, Palo Alto, California, U.S.A.
authors.forename: Duncan A
authors.initials: DA
authors.lastname: Meiklejohn
authors.forename: C Eduardo
authors.initials: CE
authors.lastname: Corrales
authors.forename: Brian M
authors.initials: BM
authors.lastname: Boldt
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Sharon
authors.forename: Kristen W
authors.initials: KW
authors.lastname: Yeom
authors.forename: John P
authors.initials: JP
authors.lastname: Carey
authors.forename: Nikolas H
authors.initials: NH
authors.lastname: Blevins
mesh_terms: D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D007759:Labyrinth Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D015995:Prevalence; D012107:Research Design; D012189:Retrospective Studies; D012665:Semicircular Canals / Q000000981:diagnostic imaging* / Q000473:pathology; D013701:Temporal Bone / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed