title: Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men with Peyronie's Disease Independent of Plaque Location.
abstract: OBJECTIVE
  Collagenase clostridium histolyticum is the only FDA (Food and Drug Administration) approved treatment for Peyronie's disease. However, to our knowledge collagenase clostridium histolyticum has not been studied in men with ventral plaques. Given this limitation and the paucity of literature on ventral plaque outcomes, we compared the results of Peyronie's disease treatment in men with different plaque locations treated with intralesional interferon-α2b.
  
  
  METHODS
  We retrospectively analyzed the records of men treated with intralesional interferon-α2b for Peyronie's disease at 1 institution from 2001 to 2014. The men received 2 million U interferon-α2b injected every 2 weeks for 6 to 24 treatments. All men underwent penile duplex Doppler ultrasound before and after interferon-α2b treatment. Patient characteristics, penile duplex Doppler ultrasound and objective measurements were reviewed. Patients were stratified into ventral and dorsal/lateral plaque cohorts with a positive response defined as a 20% or greater reduction in curvature.
  
  
  RESULTS
  A total of 131 patients with a mean±SD age of 53.8±9.5 years underwent a median of 12 intralesional interferon-α2b injections (range 6 to 24). Mean pretreatment dorsal curvature was 42.5±18.6 degrees in group 1 of 111 men and mean ventral curvature was 44.5±21.5 degrees in group 2 of 21 men (p=0.66). Overall 91% of patients responded to therapy. No significant difference was noted between the 2 groups in response rate (54% vs 52%, p=0.92) or absolute change in curvature (mean 8.7±12.6 vs 9.3±17.7 degrees, p=0.84).
  
  
  CONCLUSIONS
  Treatment with intralesional interferon-α2b provided a greater than 20% reduction in curvature in the majority of men with Peyronie's disease. This improvement was independent of plaque location.
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.
authors.forename: Carrie A
authors.initials: CA
authors.lastname: Stewart
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.
authors.forename: Faysal A
authors.initials: FA
authors.lastname: Yafi
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.
authors.forename: Margaret
authors.initials: M
authors.lastname: Knoedler
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.
authors.forename: Sree H
authors.initials: SH
authors.lastname: Mandava
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.
authors.forename: Ian R
authors.initials: IR
authors.lastname: McCaslin
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.
authors.forename: Premsant
authors.initials: P
authors.lastname: Sangkum
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.
authors.forename: Suresh
authors.initials: S
authors.lastname: Sikka
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.
authors.forename: Landon
authors.initials: L
authors.lastname: Trost
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota. Electronic address: whellst@tulane.edu.
authors.forename: Wayne J G
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D000328:Adult; D006801:Humans; D015552:Injections, Intralesional; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010411:Penile Induration / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
keywords: erectile dysfunction; injections; interferons; intralesional; penile induration; penis