title: Deleterious Effect of Radiation Therapy on Epidermodysplasia Verruciformis Patients.
abstract: BACKGROUND
  Epidermodysplasia verruciformis (EV) is a rare genodermatosis caused by specific human papillomavirus (HPV) types associated with the development of multiple squamous cell carcinomas (SCC). The treatment for this skin tumour may be difficult. Among the therapy options, radiotherapy (RT) should be avoided due to its deleterious effects on HPV-induced carcinogenesis.
  
  
  OBJECTIVE
  To describe 4 patients with EV who underwent radiotherapy to treat cutaneous SCC.
  
  
  METHODS
  This is a retrospective study. The evolution of cutaneous SCC after adjuvant radiotherapy in 4 patients with EV was observed.
  
  
  RESULTS
  This study included 4 patients with diagnosis of EV. All 4 of the patients had cutaneous SCC. They underwent surgical resection and adjuvant radiotherapy. Over a period of up to 2 years, there was aggressive tumour recurrence.
  
  
  CONCLUSIONS
  Radiotherapy might be associated with progression of SCC in patients with EV, and it is recommended that radiotherapy should be avoided in this patient population.
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Walmar Roncalli
authors.initials: WR
authors.lastname: de Oliveira
authors.affiliation: University of São Paulo, São Paulo, Brazil lana_luiza@hotmail.com.
authors.forename: Lana Luiza
authors.initials: LL
authors.lastname: da Cruz Silva
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Cyro Festa
authors.initials: CF
authors.lastname: Neto
authors.affiliation: The University of Texas Health Science Center, Houston, TX, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Tyring
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000821:virology*; D004819:Epidermodysplasia Verruciformis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000532:radiotherapy / Q000821:virology*
keywords: epidermodysplasia verruciformis; radiotherapy; skin cancer