title: Improved sensitivity and specificity for resting state and task fMRI with multiband multi-echo EPI compared to multi-echo EPI at 7 T.
abstract: A multiband multi-echo (MBME) sequence is implemented and compared to a matched standard multi-echo (ME) protocol to investigate the potential improvement in sensitivity and spatial specificity at 7 T for resting state and task fMRI. ME acquisition is attractive because BOLD sensitivity is less affected by variation in T2*, and because of the potential for separating BOLD and non-BOLD signal components. MBME further reduces TR thus increasing the potential reduction in physiological noise. In this study we used FSL-FIX to clean ME and MBME resting state and task fMRI data (both 3.5mm isotropic). After noise correction, the detection of resting state networks improves with more non-artifactual independent components being observed. Additional activation clusters for task data are discovered for MBME data (increased sensitivity) whereas existing clusters become more localized for resting state (improved spatial specificity). The results obtained indicate that MBME is superior to ME at high field strengths.
authors.affiliation: Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Trigon 204 P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands; Present address: Case Center for Imaging Research, Department of Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA. Electronic address: rasim.boyacioglu@donders.ru.nl.
authors.forename: Rasim
authors.initials: R
authors.lastname: Boyacioğlu
authors.affiliation: Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Trigon 204 P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.
authors.forename: Jenni
authors.initials: J
authors.lastname: Schulz
authors.affiliation: Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Trigon 204 P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands; Nuffield Department of Clinical Neurosciences, Oxford Centre for Functional MRI of the Brain, University of Oxford, United Kingdom.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Koopmans
authors.affiliation: Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Trigon 204 P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands; Present address: Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
authors.forename: Markus
authors.initials: M
authors.lastname: Barth
authors.affiliation: Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Trigon 204 P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands; Erwin L. Hahn Institute for Magnetic Resonance Imaging, UNESCO-Weltkulturerbe Zollverein, Leitstand Kokerei Zollverein, Arendahls Wiese 199, D-45141 Essen, Germany; MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, NL-7500 AE Enschede, The Netherlands.
authors.forename: David G
authors.initials: DG
authors.lastname: Norris
mesh_terms: D000328:Adult; D016477:Artifacts; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: FIX; High field; ICA; Multi-echo; Physiological noise; Precision; Simultaneous multi-slice; Stroop