title: Could zoledronic acid prevent root resorption in replanted rat molar?
abstract: OBJECTIVE
  In this study, we evaluated whether zoledronate could suppress the progression of external root resorption in rat due to delayed replantation by inhibiting osteoclastic activity. Also, we estimated the optimal dosage of zoledronate in root treatment of the rat model for a maximum effect of zoledronate.
  
  
  METHODS
  Maxillary first molars in Sprague Dawley rats (N = 84) were extracted, dried for 60 min, and then replanted. The rats were divided into 6 groups (1 mM alendronate, and 1, 5, 10, 20, 40 μM zoledronate). At 4 and 8 weeks postreplantation, the animals were sacrificed and evaluated by radiographic and histological analysis.
  
  
  CONCLUSIONS
  There were no significant differences at 4 weeks. However, at 8 weeks, 10, 20, and 40 μM ZOL showed more increased radiopaque and smaller periapical lesion in radiographic analysis. In histological analysis, all groups showed similar inflammatory root resorption rate at 4 weeks. However, at 8 weeks, 20 and 40 μM ZOL showed lower rate than those of other groups (P < 0.05). In concerning of replacement resorption, there were no significant differences statistically. In this animal experiment, zoledronate was capable of limiting the occurrence of root resorption in delayed replantation model. In particular, 20 μM dosage of zoledronate solution showed the most effective dose in long-term follow up and might be suitable for inhibition of root resorption in delayed tooth replantation.
authors.affiliation: Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Yoo
authors.affiliation: Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
authors.forename: Mi Sun
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Maxillofacial Surgery, School of dentistry, Kyung Hee University, Seoul, Korea.
authors.forename: Yong-Dae
authors.initials: YD
authors.lastname: Kwon
authors.affiliation: Department of Maxillofacial Tissue Regeneration and Research Center for Tooth & Periodontal Regeneration (MRC), School of Dentistry, Kyung Hee University, Seoul, Korea.
authors.forename: Eun-Cheol
authors.initials: EC
authors.lastname: Kim
authors.affiliation: Department of Pediatric Dentistry, Kyung Hee University Dental Hospital, Gangdong, Kyung Hee University, Seoul, Korea.
authors.forename: Kwang Chul
authors.initials: KC
authors.lastname: Kim
authors.affiliation: Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Choi
mesh_terms: D019386:Alendronate / Q000494:pharmacology*; D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D004164:Diphosphonates / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012391:Root Resorption / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D014090:Tooth Replantation; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D019386:Alendronate
keywords: avulsion; replacement resorption; replantation; soft X-ray; zoledronate; zoledronic acid