title: Antimüllerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels <1 ng/mL versus 1-4 ng/mL.
abstract: OBJECTIVE
  To determine whether antimüllerian hormone (AMH) levels predict the availability of good-quality supernumerary blastocysts for cryopreservation.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Two fertility centers.
  
  
  METHODS
  First fresh IVF cycles (n = 247) grouped as follows: 40 women <35 year old with AMH <1 ng/mL and 77 women with AMH 1-4 ng/mL; 62 women ≥35 year old with AMH <1 ng/mL, and 68 women with AMH 1-4 ng/mL.
  
  
  METHODS
  AMH level measured before IVF with ovarian stimulation protocols based on patient age and AMH level, including short gonadotropin-releasing hormone (GnRH) agonist, GnRH antagonist, or GnRH agonist microdose flare; supernumerary good-quality blastocysts cryopreserved on days 5 or 6 after retrieval.
  
  
  METHODS
  Supernumerary good-quality blastocysts for cryopreservation in relation to AMH levels.
  
  
  RESULTS
  Among women <35 years of age, there was a statistically significant difference in the number of patients with supernumerary good-quality blastocysts for cryopreservation between the groups with AMH <1 ng/mL and AMH 1-4 ng/mL (30.0% vs. 58.4%) when adjusted for age. Among women ≥35 years of age, there was a statistically significant difference in the number of patients with supernumerary good-quality blastocyst cryopreservation between groups with AMH <1 ng/mL and AMH 1-4 ng/mL (16.1% vs. 42.6%), when adjusted for age.
  
  
  CONCLUSIONS
  Low AMH levels are associated with a statistically significantly lower likelihood of blastocysts for cryopreservation as compared with higher AMH levels. This effect was seen among women both <35 and ≥35 years of age. Patient counseling should include realistic expectations for the probability of good-quality supernumerary blastocysts available for cryopreservation.
authors.affiliation: Austin Fertility and Reproductive Medicine/Westlake IVF, Austin, Texas. Electronic address: austinfertility@gmail.com.
authors.forename: Shahryar K
authors.initials: SK
authors.lastname: Kavoussi
authors.affiliation: Austin Fertility and Reproductive Medicine/Westlake IVF, Austin, Texas.
authors.forename: Kate C
authors.initials: KC
authors.lastname: Odenwald
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Boehnlein
authors.affiliation: Austin Fertility and Reproductive Medicine/Westlake IVF, Austin, Texas.
authors.forename: Roxanne B
authors.initials: RB
authors.lastname: Summers-Colquitt
authors.affiliation: Austin Fertility and Reproductive Medicine/Westlake IVF, Austin, Texas.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Pool
authors.affiliation: Austin Fertility and Reproductive Medicine/Westlake IVF, Austin, Texas.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Swain
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Jones
authors.affiliation: Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Lindstrom
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin.
authors.forename: Dan I
authors.initials: DI
authors.lastname: Lebovic
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001755:Blastocyst / Q000502:physiology*; D015925:Cryopreservation; D046149:Embryo Culture Techniques; D004624:Embryo Transfer; D005260:Female; D005298:Fertility / Q000187:drug effects; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D008423:Maternal Age; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013781:Texas; D013997:Time Factors; D016896:Treatment Outcome; D014922:Wisconsin
chemical_list: D015415:Biomarkers; D005300:Fertility Agents, Female; D054304:Anti-Mullerian Hormone
keywords: AMH; Blastocyst; antimüllerian hormone; cryopreservation; freezing