title: Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines.
abstract: A simple base and ligand free copper catalyzed method for the construction of trifluoromethylated benzoxazines has been developed by using Umemoto's reagent. It involves the oxidative difunctionalization of alkenes through tandem C-O and C-CF3 bond formations. Furthermore, synthesized benzoxazines were selectively converted into trifluoromethylated allylic and (E)-vinylic benzamides by the treatment of KO(t)Bu and CH3Li, respectively.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal By-Pass Road, Bhauri, Bhopal, Madhya Pradesh 462066, India. sangitkumar@iiserb.ac.in.
authors.forename: Sadhan
authors.initials: S
authors.lastname: Jana
authors.forename: Athira
authors.initials: A
authors.lastname: Ashokan
authors.forename: Shailesh
authors.initials: S
authors.lastname: Kumar
authors.forename: Ajay
authors.initials: A
authors.lastname: Verma
authors.forename: Sangit
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D048588:Benzoxazines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D008745:Methylation
chemical_list: D000475:Alkenes; D048588:Benzoxazines; D003300:Copper