title: An Extended-gate Type Organic FET Based Biosensor for Detecting Biogenic Amines in Aqueous Solution.
abstract: This study is the first to report on the detection of biogenic amines in an aqueous solution using an organic field-effect transistor (OFET) device with an extended gate electrode modified with a layer of diamine oxidase and a horseradish peroxidase osmium-redox polymer. The limit of detection (LOD) for histamine was estimated to be 1.2 μM. These results reveal that extended-gate type OFET devices are highly suitable enzyme-based biosensors for the detection of biogenic amine levels.
authors.affiliation: Research Center for Organic Electronics (ROEL), Graduate School of Science and Engineering, Yamagata University.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Minami
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Sato
authors.forename: Tsukuru
authors.initials: T
authors.lastname: Minamiki
authors.forename: Shizuo
authors.initials: S
authors.lastname: Tokito
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000737:chemistry / Q000378:metabolism; D001679:Biogenic Amines / Q000032:analysis* / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation*; D004566:Electrodes; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D006632:Histamine / Q000032:analysis / Q000737:chemistry; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism; D057230:Limit of Detection; D010084:Oxidation-Reduction; D012996:Solutions; D014173:Transistors, Electronic; D014867:Water / Q000737:chemistry*
chemical_list: D001679:Biogenic Amines; D004800:Enzymes, Immobilized; D012996:Solutions; D014867:Water; D006632:Histamine; D006735:Horseradish Peroxidase; D006631:Amine Oxidase (Copper-Containing)