title: Interaction of synchronized dynamics in cortex and basal ganglia in Parkinson's disease.
abstract: Parkinson's disease pathophysiology is marked by increased oscillatory and synchronous activity in the beta frequency band in cortical and basal ganglia circuits. This study explores the functional connections between synchronized dynamics of cortical areas and synchronized dynamics of subcortical areas in Parkinson's disease. We simultaneously recorded neuronal units (spikes) and local field potentials (LFP) from subthalamic nucleus (STN) and electroencephalograms (EEGs) from the scalp in parkinsonian patients, and analysed the correlation between the time courses of the spike-LFP synchronization and inter-electrode EEG synchronization. We found the (non-invasively obtained) time course of the synchrony strength between EEG electrodes and the (invasively obtained) time course of the synchrony between spiking units and LFP in STN to be weakly, but significantly, correlated with each other. This correlation is largest for the bilateral motor EEG synchronization, followed by bilateral frontal EEG synchronization. Our observations suggest that there may be multiple functional modes by which the cortical and basal ganglia circuits interact with each other in Parkinson's disease: not only may synchronization be observed between some areas in cortex and the basal ganglia, but also synchronization within cortex and within basal ganglia may be related, suggesting potentially a more global functional interaction. More coherent dynamics in one brain region may modulate or activate the dynamics of another brain region in a more powerful way, causing correlations between changes in synchrony strength in the two regions.
authors.affiliation: Department of Mathematical Sciences and Center for Mathematical Biosciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
authors.forename: Sungwoo
authors.initials: S
authors.lastname: Ahn
authors.affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: S Elizabeth
authors.initials: SE
authors.lastname: Zauber
authors.affiliation: Department of Mathematical Sciences and Center for Mathematical Biosciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.|Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Worth
authors.affiliation: Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Witt
authors.affiliation: Department of Mathematical Sciences and Center for Mathematical Biosciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.|Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Leonid L
authors.initials: LL
authors.lastname: Rubchinsky
mesh_terms: D000200:Action Potentials; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001479:Basal Ganglia / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003344:Cortical Synchronization / Q000502:physiology*; D046690:Deep Brain Stimulation; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D012815:Signal Processing, Computer-Assisted; D020531:Subthalamic Nucleus / Q000503:physiopathology*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa
keywords: EEG; LFP; subthalamic nucleus; synchronization