title: Stromal cell-derived factor-1 alpha alleviates hypoxic-ischemic brain damage in mice.
abstract: Hypoxic-ischemic brain damage (HIBD) is a major cause of acute deaths and chronic nervous system damage. There is good evidence that stromal cell-derived factor-1 alpha (SDF-1α) has been receiving much interest in its role in the treatment of ischemic diseases. Here we aim to investigate the effect of intraperitoneal delivery of SDF-1α after experimental hypoxia-ischemia (HI) and the potentially involved mechanisms. A total of 129 mice were subjected to unilateral carotid artery ligation followed by 2.5 h of hypoxia, randomly assigned to three groups: sham, HI + vehicle and HI + SDF-1α. Mice treated with SDF-1α showed recovery of spatial learning abilities and pathological conditions, decreased number of apoptotic cells, and elevated expression of SDF-1α and its cognate receptor, CXC chemokine receptor-4 (CXCR4). Meanwhile, the increased number of mesenchymal stem cells (MSCs) was found in peripheral blood after SDF-1α treatment. Taken together, the treatment of SDF-1α after HIBD contributed to an improved functional recovery, and this behavioral restoration was paralleled by a reduction of apoptosis and mobilization of MSCs via SDF-1α/CXCR4.
authors.affiliation: College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China. Electronic address: qinyu3587@126.com.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yu
authors.affiliation: College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Bone Marrow Transplantation Center, The First Affiliate Hospital, Medical School of Zhejiang University, Hangzhou, Zhejiang 310003, PR China.
authors.forename: Lizhen
authors.initials: L
authors.lastname: Liu
authors.affiliation: The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Cong
authors.affiliation: The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Ge
authors.affiliation: College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
authors.forename: Deju
authors.initials: D
authors.lastname: Lin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D054377:Chemokine CXCL12 / Q000378:metabolism / Q000502:physiology*; D003071:Cognition; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D019718:Receptors, CXCR4 / Q000378:metabolism
chemical_list: C514936:CXCR4 protein, mouse; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4
keywords: Brain damage; CXC chemokine receptor-4; Functional recovery; Hypoxic-ischemic; Stromal cell-derived factor-1 alpha