title: Analysis of various risk factors affecting potentially malignant disorders and oral cancer patients of Central India.
abstract: BACKGROUND
  The use of tobacco/betel quid can alone lead to death. India is the fourth largest consumer of tobacco/betel quid in the world and the third-largest producer of tobacco/betel quid after China and Brazil.
  
  
  OBJECTIVE
  A case-control study was carried out to assess the prevalence and various risk factors among potentially malignant disorders (PMD) and oral cancer patients of central India.
  
  
  METHODS
  A total of 100 clinically and histopathologically diagnosed PMD and oral cancer patients were selected for the study.
  
  
  METHODS
  A histopathologically confirmed 100 patients who were suffering from PMD and oral cancers were selected and an equal number 100 healthy controls who were age- and sex-matched at par with the cases were also examined and interviewed. Chi-square (χ(2)) test and adjusted odds ratio (ORs) with 95% confidence interval (CI) were calculated to estimate the suspected risk factors for PMD and oral cancers by using multivariate logistic regression analysis. Significance level was set at P < 0.05.
  
  
  RESULTS
  Statistically significant difference was observed in the age group, socioeconomic status (SES), duration, frequency, exposure time and synergistic effect of tobacco/betel quid chewing, smoking, and alcohol drinking in our study population.
  
  
  CONCLUSIONS
  Chewing tobacco/betel quid is a strong risk factor in the development of PMD and oral cancer. Also age, gender, SES, education, and occupation influence the development of PMD and oral cancer.
authors.affiliation: Department of Oral Pathology, Microbiology and Forensic Odontology, Krishna Institute of Medical Sciences University, Malkapur, Karad, Satara, India.
authors.forename: Vidya
authors.initials: V
authors.lastname: Kadashetti
authors.forename: Minal
authors.initials: M
authors.lastname: Chaudhary
authors.forename: Swati
authors.initials: S
authors.lastname: Patil
authors.forename: Madhuri
authors.initials: M
authors.lastname: Gawande
authors.forename: K M
authors.initials: KM
authors.lastname: Shivakumar
authors.forename: Snehal
authors.initials: S
authors.lastname: Patil
authors.forename: R C
authors.initials: RC
authors.lastname: Pramod
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D016017:Odds Ratio; D011159:Population Surveillance; D012307:Risk Factors; D012907:Smoking; D014030:Tobacco, Smokeless / Q000009:adverse effects*; D055815:Young Adult