title: Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story.
abstract: Cardiac hypertrophy is the most documented cardiomyopathy following hyperthyroidism in experimental animals. Thyroid hormone-induced cardiac hypertrophy is described as a relative ventricular hypertrophy that encompasses the whole heart and is linked with contractile abnormalities in both right and left ventricles. The increase in oxidative stress that takes place in experimental hyperthyroidism proposes that reactive oxygen species are key players in the cardiomyopathy frequently reported in this endocrine disorder. The goal of this review is to shed light on the effects of thyroid hormones on the development of oxidative stress in the heart along with the subsequent cellular and molecular changes. In particular, we will review the role of thyroid hormone-induced oxidative stress in the development of cardiomyocyte hypertrophy and associated cardiac dysfunction, as well as the potential effectiveness of antioxidant treatments in attenuating these hyperthyroidism-induced abnormalities in experimental animal models.
authors.affiliation: Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA ; Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
authors.forename: Mohammad T
authors.initials: MT
authors.lastname: Elnakish
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
authors.forename: Amany A E
authors.initials: AA
authors.lastname: Ahmed
authors.affiliation: Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA ; Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mohler
authors.affiliation: Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA ; Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Paul M L
authors.initials: PM
authors.lastname: Janssen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D006332:Cardiomegaly / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006980:Hyperthyroidism / Q000150:complications*; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013963:Thyroid Hormones / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D013963:Thyroid Hormones