title: Measuring Cognition in Bipolar Disorder with Psychosis Using the MATRICS Consensus Cognitive Battery.
abstract: Given the substantial overlap in cognitive dysfunction between bipolar disorder (BD) and schizophrenia (SZ), we examined the utility of the MATRICS Consensus Cognitive Battery (MCCB)-developed for use in SZ-for the measurement of cognition in patients with BD with psychosis (BDP) and its association with community functioning. The MCCB, Multnomah Community Ability Scale, and measures of clinical symptoms were administered to participants with BDP (n=56), SZ (n=37), and healthy controls (HC) (n=57). Groups were compared on clinical and cognitive measures; linear regressions examined associations between MCCB and community functioning. BDP and SZ groups performed significantly worse than HC on most neurocognitive domains; BDP and HC did not differ on Social Cognition. Patients with BDP performed better than patients with SZ on most cognitive measures, although groups only differed on social cognition, working memory, verbal memory, and the composite after controlling for clinical variables. MCCB was not associated with community functioning. The MCCB is an appropriate measure of neurocognition in BDP but does not appear to capture social cognitive deficits in this population. The addition of appropriate social cognitive measures is recommended.
authors.affiliation: 1Schizophrenia and Bipolar Disorder Program,McLean Hospital,Belmont,Massachusetts.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Sperry
authors.affiliation: 1Schizophrenia and Bipolar Disorder Program,McLean Hospital,Belmont,Massachusetts.
authors.forename: Lauren K
authors.initials: LK
authors.lastname: O'Connor
authors.affiliation: 1Schizophrenia and Bipolar Disorder Program,McLean Hospital,Belmont,Massachusetts.
authors.forename: Dost
authors.initials: D
authors.lastname: Öngür
authors.affiliation: 1Schizophrenia and Bipolar Disorder Program,McLean Hospital,Belmont,Massachusetts.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Cohen
authors.affiliation: 3Harvard Medical School,Boston,Massachusetts.
authors.forename: Matcheri S
authors.initials: MS
authors.lastname: Keshavan
authors.affiliation: 1Schizophrenia and Bipolar Disorder Program,McLean Hospital,Belmont,Massachusetts.
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Lewandowski
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000150:complications*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D032921:Consensus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D055815:Young Adult
keywords: Bipolar disorder; Cognition; Neuropsychology; Psychometrics; Psychosocial functioning; Schizophrenia