title: Collagen based polyurethanes—A review of recent advances and perspective.
abstract: Collagen is mostly found in fibrous tissues such as tendons, ligaments and skin. Collagen makes up approximately 30% of the proteins within the body. These are tough and strong structures found all over the body: in bones, tendons and ligaments. Collagen being the most abundant protein provides tensile strength via cell matrix interactions to tissue architecture. Biomimetic materials of collagen origin gained wide spread acceptance in clinical applications. Vitamin C deficiency causes scurvy a serious and painful disease in which defective collagen prevents the formation of strong connective tissue, gums deteriorate and bleed, with loss of teeth; skin discolors, and wounds do not heal. Effective collagens prevent the manifestation of such disorders. Polyurethanes on the other hand are frequently used for various applications as they offered in wide-ranging of compositions, properties and complex structures. Collagen/PU bio-composites have potential array for biomedical applications. Considering versatile properties of the elongated fibrils and wide industrial and biomedical applications including biocompatibility of polyurethane, this review shed a light on collagen based polyurethane materials with their potential applications especially focusing the bio-medical field.
authors.affiliation: Institute of Chemistry, Government College University, Allama Iqbal Road, Faisalabad 38030, Pakistan. Electronic address: mohammadzuber@gmail.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zuber
authors.affiliation: Institute of Chemistry, Government College University, Allama Iqbal Road, Faisalabad 38030, Pakistan. Electronic address: fatimazia2011@gmail.com.
authors.forename: Fatima
authors.initials: F
authors.lastname: Zia
authors.affiliation: Institute of Chemistry, Government College University, Allama Iqbal Road, Faisalabad 38030, Pakistan. Electronic address: ziakmpkpolym@yahoo.com.
authors.forename: Khalid Mahmood
authors.initials: KM
authors.lastname: Zia
authors.affiliation: Institute of Chemistry, Government College University, Allama Iqbal Road, Faisalabad 38030, Pakistan. Electronic address: shazia.shazia.qasim@gmail.com.
authors.forename: Shazia
authors.initials: S
authors.lastname: Tabasum
authors.affiliation: Institute of Chemistry, Government College University, Allama Iqbal Road, Faisalabad 38030, Pakistan. Electronic address: mahwish.gene@gmail.com.
authors.forename: Mahwish
authors.initials: M
authors.lastname: Salman
authors.affiliation: Institute of Chemistry, Government College University, Allama Iqbal Road, Faisalabad 38030, Pakistan. Electronic address: nelamsultan@yahoo.com.
authors.forename: Neelam
authors.initials: N
authors.lastname: Sultan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D003094:Collagen / Q000737:chemistry*; D055664:Electrochemical Techniques; D006801:Humans; D011140:Polyurethanes / Q000737:chemistry*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; D003094:Collagen
keywords: Biomedical applications; Collagen; Perspective; Polyurethanes; Recent advances