title: Association between KLKB1 Polymorphisms and Pulmonary Thromboembolism.
abstract: To investigate the potential correlation between the single nucleotide polymorphisms (SNPs) in the KLKB1 region and pulmonary thromboembolism(PTE) in a Chinese Han population.
  
  
  
  In this case-control study, 95 patients with confirmed PTE were enrolled as the PTE group and 90 healthy subjects as the control group. The genotypes, alleles, and haplotypes of the SNPs were analyzed with PLINK 1.07 and Haploview 4.2 software using chi-square test and Logistic regression analysis. SNPs were further analyzed under three genetic models (additive, dominant, and recessive).
  
  
  
  The distribution of rs3733402 in KLKB1 gene showed significant difference between PTE group and control group (P=0.041). The distributions of GTG haplotypes consisted of rs2292423, rs4253325,and rs3733402 in KLKB1 gene were also significantly different between PTE group and control group(P=0.040).
  
  
  
  The rs3733402 locus variation in KLKB1 gene is associated with PTE in Chinese Han people.
authors.affiliation: Graduate School,CAMS and PUMC,Beijing 100730,China;National Center for Clinical Laboratories,Beijing Hospital,Beijing 100730,China.
authors.forename: Min-Ne
authors.initials: MN
authors.lastname: Wang
authors.affiliation: Department of Respiratory and Critical Care Medicine,Beijing Hospital,Bejing 100730,China.
authors.forename: Xiao-Mao
authors.initials: XM
authors.lastname: Xu
authors.affiliation: Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders,Beijing Institute of Respiratory Medicine, Department of Respiratory Disease,Chaoyang Hospital,Capital University of Medical Sciences,Beijing 100020,China.
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Zhai
authors.affiliation: Beijing Institute of Geriatric Medicine,Beijing Hospital,Beijing 100730,China.
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.affiliation: Beijing Institute of Geriatric Medicine,Beijing Hospital,Beijing 100730,China.
authors.forename: Bao-Min
authors.initials: BM
authors.lastname: Fang
authors.affiliation: Beijing Institute of Geriatric Medicine,Beijing Hospital,Beijing 100730,China.
authors.forename: Xiao
authors.initials: F
authors.lastname: Fei
authors.affiliation: Beijing Institute of Geriatric Medicine,Beijing Hospital,Beijing 100730,China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guo
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007610:Kallikreins; D020641:Polymorphism, Single Nucleotide; D011655:Pulmonary Embolism
chemical_list: D007610:Kallikreins