title: Joint Coupled-Feature Representation and Coupled Boosting for AD Diagnosis.
abstract: Recently, there has been a great interest in computer-aided Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) diagnosis. Previous learning based methods defined the diagnosis process as a classification task and directly used the low-level features extracted from neuroimaging data without considering relations among them. However, from a neuroscience point of view, it's well known that a human brain is a complex system that multiple brain regions are anatomically connected and functionally interact with each other. Therefore, it is natural to hypothesize that the low-level features extracted from neuroimaging data are related to each other in some ways. To this end, in this paper, we first devise a coupled feature representation by utilizing intra-coupled and inter-coupled interaction relationship. Regarding multi-modal data fusion, we propose a novel coupled boosting algorithm that analyzes the pairwise coupled-diversity correlation between modalities. Specifically, we formulate a new weight updating function, which considers both incorrectly and inconsistently classified samples. In our experiments on the ADNI dataset, the proposed method presented the best performance with accuracies of 94.7% and 80.1% for AD vs. Normal Control (NC) and MCI vs. NC classifications, respectively, outperforming the competing methods and the state-of-the-art methods.
authors.affiliation: State Key Laboratory for Novel Software Technology, Nanjing University, China.
authors.forename: Yinghuan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Radiology and BRIC, UNC Chapel Hill, U.S.A.
authors.forename: Heung-Il
authors.initials: HI
authors.lastname: Suk
authors.affiliation: State Key Laboratory for Novel Software Technology, Nanjing University, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Radiology and BRIC, UNC Chapel Hill, U.S.A.
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen