title: Look what else we found--clinically significant abnormalities detected during routine ROP screening.
abstract: OBJECTIVE
  The purpose of this study was to report the spectrum of anterior and posterior segment diagnoses in Asian Indian premature infants detected serendipitously during routine retinopathy of prematurity (ROP) screening during a 1 year period.
  
  
  METHODS
  A retrospective review of all Retcam (Clarity MSI, USA) imaging sessions during the year 2011 performed on infants born either <2001 g at birth and/or <34.1 weeks of gestation recruited for ROP screening was performed. All infants had a minimum of seven images at each session, which included the dilated anterior segment, disc, and macula center and the four quadrants using the 130° lens.
  
  
  RESULTS
  Of the 8954 imaging sessions of 1450 new infants recruited in 2011, there were 111 (7.66%) with a diagnosis other than ROP. Anterior segment diagnoses seen in 31 (27.9%) cases included clinically significant cataract, lid abnormalities, anophthalmos, microphthalmos, and corneal diseases. Posterior segment diagnoses in 80 (72.1%) cases included retinal hemorrhages, cherry red spots, and neonatal uveitis of infective etiologies. Of the 111 cases, 15 (13.5%) underwent surgical procedures and 24 (21.6%) underwent medical procedures; importantly, two eyes with retinoblastoma were detected which were managed timely.
  
  
  CONCLUSIONS
  This study emphasizes the importance of ocular digital imaging in premature infants. Visually significant, potentially life-threatening, and even treatable conditions were detected serendipitously during routine ROP screening that may be missed or detected late otherwise. This pilot data may be used to advocate for a possible universal infant eye screening program using digital imaging.
authors.forename: Chaitra
authors.initials: C
authors.lastname: Jayadev
authors.affiliation: Department of Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bengaluru, Karnataka, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Vinekar
authors.forename: Noel
authors.initials: N
authors.lastname: Bauer
authors.forename: Shwetha
authors.initials: S
authors.lastname: Mangalesh
authors.forename: Padmamalini
authors.initials: P
authors.lastname: Mahendradas
authors.forename: Vasudha
authors.initials: V
authors.lastname: Kemmanu
authors.forename: Ashwin
authors.initials: A
authors.lastname: Mallipatna
authors.forename: Bhujang
authors.initials: B
authors.lastname: Shetty
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D012160:Retina / Q000473:pathology*; D012166:Retinal Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D012178:Retinopathy of Prematurity / Q000150:complications / Q000175:diagnosis*; D012189:Retrospective Studies