title: Micro- and Nanoparticles for Treating Cardiovascular Disease.
abstract: Cardiovascular disease, including myocardial infarction (MI) and peripheral artery disease (PAD), afflicts millions of people in Unites States. Current therapies are insufficient to restore blood flow and repair the injured heart or skeletal muscle, respectively, which is subjected to ischemic damage following vessel occlusion. Micro- and nano-particles are being designed as delivery vehicles for growth factors, enzymes and/or small molecules to provide a sustained therapeutic stimulus at the injured tissue. Depending on the formulation, the particles can be injected directly into the heart or skeletal muscle, or accumulate at the site of injury following an intravenous injection. In this article we review existing particle based therapies for treating MI and PAD.
authors.affiliation: Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California, United States.
authors.forename: S
authors.initials: S
authors.lastname: Suarez
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences and KACST UCSD Center of Excellence in Nanomedicine, University of California, San Diego, La Jolla, California, United States.
authors.forename: A
authors.initials: A
authors.lastname: Almutairi
authors.affiliation: Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California, United States.
authors.forename: K L
authors.initials: KL
authors.lastname: Christman
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology*; D016503:Drug Delivery Systems / Q000379:methods*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous / Q000379:methods*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D058729:Peripheral Arterial Disease / Q000628:therapy*