title: Prospective Randomized Intraindividual Comparison of Posterior Capsule Opacification After Implantation of an IOL With and Without Heparin Surface Modification.
abstract: OBJECTIVE
  To compare posterior capsule opacification (PCO) of a hydrophobic acrylic heparin surface modified intraocular lens (HSM-IOL) and an uncoated IOL (UC-IOL) 1 year after implantation.
  
  
  METHODS
  One hundred two eyes of 51 patients underwent routine phacoemulsification with randomized implantation of a HSM-IOL in one eye (the HSM-IOL group) and a UC-IOL in the fellow eye (the UC-IOL group). Morphologic PCO evaluation was performed comparing digital photographs in retroillumination using the Evaluation of Posterior Capsule Opacification (EPCO) system, grading the density of the opacification from 0 to 4 (0 = none, 1 = minimal, 2 = mild, 3 = moderate, and 4 = severe). Distance visual acuities, subjective manifest refraction, pupil size, straylight measurements, flare in the anterior chamber using a laser flare meter, and contrast sensitivity were also evaluated.
  
  
  RESULTS
  The mean total EPCO score was slightly higher in the HSM-IOL group (0.50 ± 0.45) compared to the UC-IOL group (0.45 ± 0.46), but did not reach statistical significance. No statistically significant differences were found in the other main outcome parameters (straylight measurement, distance visual acuities, flare in the anterior chamber, and mesopic and photopic contrast sensitivity) when comparing both IOLs.
  
  
  CONCLUSIONS
  Although the HSM-IOL showed decreased flare 1 day postoperatively, no statistically significant differences regarding PCO were found 1 year postoperatively.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Krall
authors.forename: Eva M
authors.initials: EM
authors.lastname: Arlt
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Jell
authors.forename: Clemens
authors.initials: C
authors.lastname: Strohmaier
authors.forename: Sarah
authors.initials: S
authors.lastname: Moussa
authors.forename: Alois K
authors.initials: AK
authors.lastname: Dexl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D058442:Capsule Opacification / Q000209:etiology*; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D015350:Contrast Sensitivity / Q000502:physiology; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D007910:Lenses, Intraocular; D008027:Light; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D057852:Posterior Capsule of the Lens / Q000473:pathology*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D012542:Scattering, Radiation; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020099:Coated Materials, Biocompatible; D005343:Fibrinolytic Agents; D006493:Heparin