title: Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle-peptide hybrids.
abstract: A novel gold nanoparticle-peptide hybrid strategy was developed to intracellularly deliver a potent PKCδ inhibitor peptide for the treatment of acute lung injury. The gold nanoparticle-peptide hybrids showed good stability with high uptake, and demonstrated in vitro and in vivo efficacy. Our formulation strategy shows great promise in intracellular delivery of peptides.
authors.affiliation: Toronto General Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada. mingyao.liu@utoronto.ca.
authors.forename: Daiyoon
authors.initials: D
authors.lastname: Lee
authors.forename: Jinbo
authors.initials: J
authors.lastname: Zhao
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Shuyun
authors.initials: S
authors.lastname: Xu
authors.forename: Hyunhee
authors.initials: H
authors.lastname: Kim
authors.forename: Shaun
authors.initials: S
authors.lastname: Pacheco
authors.forename: Shaf
authors.initials: S
authors.lastname: Keshavjee
authors.forename: Mingyao
authors.initials: M
authors.lastname: Liu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D018613:Microscopy, Confocal; D010316:Particle Size; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*; D051745:Protein Kinase C-delta / Q000037:antagonists & inhibitors / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy
chemical_list: D004337:Drug Carriers; D010455:Peptides; D047428:Protein Kinase Inhibitors; D006046:Gold; D051745:Protein Kinase C-delta