title: Hepatocellular carcinoma in Asia: Prevention strategy and planning.
abstract: OBJECTIVE
  To review all of epidemiological and etiological aspects of hepatocellular carcinoma (HCC) and examined the prevention of this disease in Asia.
  
  
  METHODS
  We conducted a systematic review according to the PRISMA guidelines. We were chosen articles that published previously, from PubMed (MEDLINE), the Cochrane database and Scopus. The key words used in this research were as follows: HCC in Asia and the way of prevention of this disease, with no language limitations. We selected those papers published before 2014 that we considered to be most important and appropriate. All relevant articles were accessed in full text and all relevant materials was evaluated and reviewed.
  
  
  RESULTS
  More than 70% of all new cases of liver cancer were diagnosed in Asia, a region that 75% of all those chronically infected with hepatitis B virus (HBV) in the world. Chronic HBV infection is the main cause of HCC in Asia, where the virus is endemic and vertical transmission is common. Japan, Saudi Arabia, Egypt and Pakistan are exception because of high prevalence of HCV infection in these regions. The prevalence of this cancer is high in Eastern and South-Eastern Asia, But Middle Eastern countries are characterized as moderate prevalence rate of HCC region and Central Asia and some part of Middle Eastern countries are known as low prevalence rate of HCC. In addition of HBV and HCV the other factors such as aflatoxin, alcohol, obesity, diabetes and non-alcoholic fatty liver disease (NAFLD) might be responsible for a low prevalence of HCC in Asian countries. Currently available HCC therapies, chemotherapy, surgical are inefficient, mainly due to usually late diagnosis and high recurrence rates after surgical resection, and usually end with treatment failure. Liver transplantation also remains as a difficult strategy in patients with HCC. Thus prevention of HCC by treating and prevention HBV and HCV infection, the major causative agents of HCC, and the other risk factors such as aflatoxin, alcohol, obesity, diabetes and NAFLD is of a great medical importance.
  
  
  CONCLUSIONS
  The main challenge which still present in Asia, is the high prevalence of chronic hepatitis. So, prevention of HBV and HCV is the key strategy to reduce the incidence of HCC in Asia.
authors.affiliation: Sara Ashtari, Mohamad Amin Pourhoseingholi, Afsaneh Sharifian, Mohamad Reza Zali, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Ashtari
authors.affiliation: Sara Ashtari, Mohamad Amin Pourhoseingholi, Afsaneh Sharifian, Mohamad Reza Zali, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.
authors.forename: Mohamad Amin
authors.initials: MA
authors.lastname: Pourhoseingholi
authors.affiliation: Sara Ashtari, Mohamad Amin Pourhoseingholi, Afsaneh Sharifian, Mohamad Reza Zali, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Sharifian
authors.affiliation: Sara Ashtari, Mohamad Amin Pourhoseingholi, Afsaneh Sharifian, Mohamad Reza Zali, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Zali
keywords: Asian countries; Hepatocellular carcinoma; Prevention strategy; Viral hepatitis