title: Clinical Evaluation of Sinonasal Lesions in Patients With Immunoglobulin G4-Related Disease.
abstract: OBJECTIVE
  Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease entity characterized by elevated serum IgG4 and extensive IgG4-positive plasma cell infiltration of various organs. Patients with IgG4-RD show nasal manifestations with chronic rhinosinusitis. The objective of this study was to evaluate the clinical characteristics of sinonasal lesions in patients with IgG4-RD.
  
  
  METHODS
  We evaluated radiological findings of sinonasal lesions in 79 patients with IgG4-RD who were divided into 3 groups according to severity. We also compared serological findings, including serum IgG4 and IgE levels, and eosinophil counts.
  
  
  RESULTS
  Rhinosinusitis was found in 41 patients (51.9%). Although there were no significant differences in the serum IgG4 and IgE levels of the groups, there was a significant increase in eosinophil counts (445 ± 311.9/mm³) in Group C. Furthermore, 14 of the 41 patients with rhinosinusitis (34.1%) showed improvement after prednisolone administration. Patients with IgG4-RD and serum eosinophilia tend to also have sinonasal lesions.
  
  
  CONCLUSIONS
  Rhinosinusitis is common in patients with IgG4-RD, and its pathogenesis can be similar to eosinophilic chronic rhinosinusitis.
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan kent@sapmed.ac.jp.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takano
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Abe
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Ryoto
authors.initials: R
authors.lastname: Yajima
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kakuki
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Sumito
authors.initials: S
authors.lastname: Jitsukawa
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Nomura
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Himi
mesh_terms: D002908:Chronic Disease; D004804:Eosinophils / Q000166:cytology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012220:Rhinitis / Q000188:drug therapy / Q000276:immunology*; D012720:Severity of Illness Index; D012852:Sinusitis / Q000188:drug therapy / Q000276:immunology*; D053668:Syndecan-1 / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G; C508241:SDC1 protein, human; D053668:Syndecan-1; D007073:Immunoglobulin E; D011239:Prednisolone
keywords: IgE; IgG4; IgG4-related disease; eosinophil; paranasal sinus; rhinosinusitis