title: Targeting MYC Translation in Colorectal Cancer.
abstract: There is a great interest in finding ways to inhibit the expression or activity of the "undruggable" MYC, a master regulator of transcription and one of the most deadly oncoproteins in human cancer. In this issue of Cancer Discovery, Wiegering and colleagues find a way of inhibiting translation of MYC in colorectal cancer cells by directly targeting the translation initiation factor eIF4A, resulting in inhibition of MYC-dependent proliferation of colorectal tumor cells in vitro and in vivo.
authors.affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.
authors.forename: Alina
authors.initials: A
authors.lastname: Castell
authors.affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden. Lars-Gunnar.Larsson@ki.se.
authors.forename: Lars-Gunnar
authors.initials: LG
authors.lastname: Larsson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D010442:Peptide Chain Initiation, Translational / Q000187:drug effects*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D014315:Triterpenes / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D016271:Proto-Oncogene Proteins c-myc; D014315:Triterpenes