title: Dual-modality fiber-based OCT-TPL imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques.
abstract: New optical imaging techniques that provide contrast to study both the anatomy and composition of atherosclerotic plaques can be utilized to better understand the formation, progression and clinical complications of human coronary artery disease. We present a dual-modality fiber-based optical imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques that combines optical coherence tomography (OCT) and two-photon luminescence (TPL) imaging. Experimental results from ex vivo human coronary arteries show that OCT and TPL optical contrast in recorded OCT-TPL images is complimentary and in agreement with histological analysis. Molecular composition (e.g., lipid and oxidized-LDL) detected by TPL imaging can be overlaid onto plaque microstructure depicted by OCT, providing new opportunities for atherosclerotic plaque identification and characterization.
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Austin
authors.initials: A
authors.lastname: McElroy
authors.affiliation: Division of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA ; South Texas Veterans Health Care System, San Antonio, Texas 78229, USA.
authors.forename: David
authors.initials: D
authors.lastname: Halaney
authors.affiliation: Texas Heart Institute, Houston, Texas 77030, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Vela
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Edmund
authors.initials: E
authors.lastname: Fung
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Shafat
authors.initials: S
authors.lastname: Hossain
authors.affiliation: Division of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Phipps
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Bingqing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Biwei
authors.initials: B
authors.lastname: Yin
authors.affiliation: Division of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA ; South Texas Veterans Health Care System, San Antonio, Texas 78229, USA.
authors.forename: Marc D
authors.initials: MD
authors.lastname: Feldman
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Milner
keywords: (110.4500) Optical coherence tomography; (170.6280) Spectroscopy, fluorescence and luminescence; (170.6935) Tissue characterization; (190.1900) Diagnostic applications of nonlinear optics; (190.4370) Nonlinear optics, fibers