title: Anticonvulsant properties of Euterpe oleracea in mice.
abstract: Açai (Euterpe oleracea Mart.), a highly consumed fruit in Amazon, is from a common palm with remarkable antioxidant properties. Because oxidative stress and seizures are intimately linked, this study investigated the potential neuroprotective and anticonvulsant effects of commercial clarified açai juice (EO). EO did not alter spontaneous locomotor activity. Four doses of EO were sufficient to increase latencies to both first myoclonic jerk and first generalized tonic-clonic seizure and significantly decrease the total duration of tonic-clonic seizures caused by pentylenetetrazol administration. Also, electrocortical alterations provoked by pentylenetetrazol were prevented, significantly decreasing amplitude of discharges and frequencies above 50 Hz. EO was also able to completely prevent lipid peroxidation in the cerebral cortex, showing a potent direct scavenging property. These results demonstrate for the first time that E. oleracea significantly protects against seizures and seizure-related oxidative stress, indicating an additional protection for humans who consume this fruit.
authors.affiliation: Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
authors.forename: José Rogerio
authors.initials: JR
authors.lastname: Souza-Monteiro
authors.affiliation: Laboratório de Farmacologia e Toxicologia de Produtos Naturais e, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
authors.forename: Moisés
authors.initials: M
authors.lastname: Hamoy
authors.affiliation: Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
authors.forename: Danielle
authors.initials: D
authors.lastname: Santana-Coelho
authors.affiliation: Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
authors.forename: Gabriela P F
authors.initials: GP
authors.lastname: Arrifano
authors.affiliation: Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
authors.forename: Ricardo S O
authors.initials: RS
authors.lastname: Paraense
authors.affiliation: Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
authors.forename: Allan
authors.initials: A
authors.lastname: Costa-Malaquias
authors.affiliation: Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
authors.forename: Jackson R
authors.initials: JR
authors.lastname: Mendonça
authors.affiliation: Petruz Fruity, Castanhal, Pará, Brazil.
authors.forename: Rafael F
authors.initials: RF
authors.lastname: da Silva
authors.affiliation: Petruz Fruity, Castanhal, Pará, Brazil.
authors.forename: Wallena S C
authors.initials: WS
authors.lastname: Monteiro
authors.affiliation: College of Food Engineering & Centre for the Valorization of Bioactive Compounds from Amazonia, UFPA, Belém, Brazil.
authors.forename: Hervé
authors.initials: H
authors.lastname: Rogez
authors.affiliation: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Diogo L
authors.initials: DL
authors.lastname: de Oliveira
authors.affiliation: Laboratório de Neuroquímica Molecular e Celular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
authors.forename: José Luiz M
authors.initials: JL
authors.lastname: do Nascimento
authors.affiliation: Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil. Electronic address: maria.elena.crespo.lopez@gmail.com.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Crespo-López
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D065748:Euterpe / Q000378:metabolism; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D012640:Seizures / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D000975:Antioxidants; D010936:Plant Extracts; D010433:Pentylenetetrazole
keywords: Amazon; Anticonvulsant; EEG; Euterpe oleracea; Oxidative stress; Seizure