title: Differentially Addressable Cavities within Metal-Organic Cage-Cross-Linked Polymeric Hydrogels.
abstract: Here we report a new class of hydrogels formed by polymers that are cross-linked through subcomponent self-assembled metal-organic cages. Selective encapsulation of guest molecules within the cages creates two distinct internal phases within the hydrogel, which allows for contrasting release profiles of related molecules depending on their aptitude for encapsulation within the cages. The hydrogels were fabricated into microparticles via a droplet-based microfluidic approach and proved responsive to a variety of stimuli, including acid and competing amine or aldehyde subcomponents, allowing for the triggered release of cargo.
authors.affiliation: †University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Foster
authors.affiliation: †University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Parker
authors.affiliation: †University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Belenguer
authors.affiliation: ‡Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatuta, Midori-ku, Yokohama 226-8502, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kishi
authors.affiliation: †University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Sam
authors.initials: S
authors.lastname: Sutton
authors.affiliation: †University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Chris
authors.initials: C
authors.lastname: Abell
authors.affiliation: †University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Nitschke
mesh_terms: D000143:Acids / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000143:Acids; D000447:Aldehydes; D000588:Amines; D003432:Cross-Linking Reagents; D005296:Ferrous Compounds; D020100:Hydrogels; D011092:Polyethylene Glycols