title: High metabolic N-oxidation of voriconazole in a patient with refractory aspergillosis and CYP2C19*17/*17 genotype.
authors.affiliation: Laboratory of pharmacology and toxicology, CHU Amiens Picardie, UPJV, INSERM U1088, France.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Bennis
authors.affiliation: Laboratory of pharmacology and toxicology, CHU Amiens Picardie, UPJV, INSERM U1088, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Bodeau
authors.affiliation: Laboratory of pharmacology and toxicology, Nantes University Hospital, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Bouquié
authors.affiliation: Laboratory of pharmacology and toxicology, Nantes University Hospital, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Deslandes
authors.affiliation: Department of Pharmacology, EA 4123, Le Kremlin Bicêtre University Hospital, Universite Paris Sud, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Verstuyft
authors.affiliation: Department of Clinical Hematology, CHU Amiens Picardie, France.
authors.forename: Bérangère
authors.initials: B
authors.lastname: Gruson
authors.affiliation: Laboratory of pharmacology and toxicology, CHU Amiens Picardie, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Andréjak
authors.affiliation: Laboratory of pharmacology and toxicology, CHU Amiens Picardie, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Lemaire-Hurtel
authors.affiliation: Laboratory of mycology, CHU Amiens Picardie, France.
authors.forename: Taieb
authors.initials: T
authors.lastname: Chouaki
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*; D001228:Aspergillosis / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D010084:Oxidation-Reduction; D017211:Treatment Failure; D065819:Voriconazole / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*
chemical_list: D000935:Antifungal Agents; D065731:Cytochrome P-450 CYP2C19; D065819:Voriconazole