title: Association between the traditional Chinese medicine pathological factors of opioid addiction and DRD2/ANKK1 TaqIA polymorphisms.
abstract: BACKGROUND
  As we known, Traditional Chinese Medicine (TCM) helps to prevent the relapse of drug addiction. However, the scientific basis of TCM remains unclear because of limitations of current reductionist approaches. We aimed to explore the possible mechanism of how ANKK1 TaqIA (A1/A2) [rs1800497(T/C)] affects the relapse of opioid addiction on the perspective of Chinese traditional medicine.
  
  
  METHODS
  The ANKK1 TaqIA (A1/A2) [rs1800497(T/C)] of the dopamine D2 receptor (DRD2) polymorphisms were genotyped in a case-control sample consisting of 347 opioid addicts and 155 healthy controls with RT-PCR and the TCM pathological factors were collected by means of Syndrome Elements Differentiation in the case-control sample.
  
  
  RESULTS
  DRD2/ANKK1 TaqIA Polymorphisms has no relation with opioid addiction relapse; but for those who were diagnosed with phlegm syndrome, DRD2/ANKK1 TaqIA Polymorphisms affect the replapse of apioid addiction (P < 0.05).
  
  
  CONCLUSIONS
  DRD2/ANKK1 TaqIA is associated with opioid addict and it is obvious in opioid addicts who suffer from the phlegm syndrome.
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, PR China. 13665075084@126.com.
authors.forename: Meimei
authors.initials: M
authors.lastname: Cai
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, PR China. szy664299597@163.com.
authors.forename: Zhiyang
authors.initials: Z
authors.lastname: Su
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, PR China. zouhongjayfans@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Zou
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, PR China. memory5253@163.comC.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, PR China. shenjianying0721@gmail.com.
authors.forename: Jianying
authors.initials: J
authors.lastname: Shen
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, PR China. daph2220@gmail.com.
authors.forename: Lingyuan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Biomedical Sciences, Fudan University, Shanghai, PR China. walter-teng@163.com.
authors.forename: Teng
authors.initials: T
authors.lastname: Wang
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, PR China. yzy813@yahoo.com.cn.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, PR China. fjzylcd@126.com.
authors.forename: Candong
authors.initials: C
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000453:epidemiology* / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D055815:Young Adult
chemical_list: C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2; C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases