title: Mean Platelet Volume as a Biomarker for Thyroid Carcinoma.
abstract: AbstractObjective: This study aimed to determine the relationship between MPV and thyroid malignancy by comparing patients who underwent surgery for benign or malignant thyroid diseases.
  
  
  BACKGROUND
  Mean platelet volume (MPV) is a useful early indicator of platelet activation. Platelets differ in terms of functional activity and size. Large platelets are relatively new, more reactive and produce more thrombogenic factors. Therefore, in conditions that involve increased platelet activation, an increase in the proportion of young platelets and MPV is expected.
  
  
  METHODS
  This study involved 146 patients who underwent total thyroidectomy because of benign (99 patients) or malignant (47 patients) diseases of the thyroid. Data on age, sex, MPV, white blood cell (WBC) count, hemoglobin level and platelet count were collected retrospectively.
  
  
  RESULTS
  MPV was significantly higher in patients with malignant thyroid diseases than in those with benign thyroid diseases. Age, sex, hemoglobin level, WBC count and platelet count did not significantly differ between the two groups.
  
  
  CONCLUSIONS
  MPV was significantly higher in patients with thyroid malignancies than in patients with benign thyroid diseases. We propose that MPV might be an important predictive factor for thyroid malignancies. Further prospective studies with a larger number of patients in high-volume endocrine surgery centers are required to confirm our findings.
authors.affiliation: b Dumlupinar University, Faculty of Medicine, Kutahya, 43100, Turkey.
authors.forename: Zulfu
authors.initials: Z
authors.lastname: Bayhan
authors.forename: Sezgin
authors.initials: S
authors.lastname: Zeren
authors.forename: Isa
authors.initials: I
authors.lastname: Ozbay
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kahraman
authors.forename: Faik
authors.initials: F
authors.lastname: Yaylak
authors.forename: Cagri
authors.initials: C
authors.lastname: Tiryaki
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ekici
keywords: Platelet activation; mean platelet volume.; platelet count; thyroid carcinoma