title: Relationship of adiponectin and its multimers to metabolic indices in cats during weight change.
abstract: Adiponectin is an important anti-inflammatory hormone secreted from adipose tissue. The high-molecular-weight form of adiponectin (HMW) closely correlates with insulin sensitivity in human beings. This study uses a novel method of size-exclusion gel chromatography combined with enzyme-linked immunosorbent assay to measure HMW feline adiponectin and determine its relationship to leptin, cholesterol, and insulin sensitivity as cats gain and lose weight. In addition, total adiponectin and its messenger RNA expression in subcutaneous adipose tissue were measured. No correlations were found between total serum adiponectin and subcutaneous adipose messenger RNA expression, fat mass, or measures of insulin sensitivity. This study demonstrates that cats have high percentages of HMW adiponectin. Although weak correlations between HMW adiponectin and fat mass were detected, additional cats are needed to determine if the correlations are significant.
authors.affiliation: Department of Small Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA. Electronic address: witzel@utk.edu.
authors.forename: A L
authors.initials: AL
authors.lastname: Witzel
authors.affiliation: Department of Small Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Kirk
authors.affiliation: Department of Biomedical and Diagnostic Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Kania
authors.affiliation: Department of Small Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Bartges
authors.affiliation: Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Boston
authors.affiliation: Department of Small Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA.
authors.forename: T
authors.initials: T
authors.lastname: Moyers
authors.affiliation: Department of Small Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA.
authors.forename: H
authors.initials: H
authors.lastname: Byrd
authors.affiliation: Department of Small Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lauten
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001823:Body Composition; D002415:Cats / Q000502:physiology*; D005260:Female; D008297:Male; D050177:Overweight / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D052242:Adiponectin
keywords: Adipokine; Adiponectin; Cat; Feline; Leptin