title: A highlight from the LUPUS 2014 meeting: eight great ideas.
abstract: This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.
authors.affiliation: Division of Rheumatology, Department of Medicine , NYU School of Medicine , New York, New York , USA.
authors.forename: Jill P
authors.initials: JP
authors.lastname: Buyon
authors.affiliation: Departments of Medicine, Section of Rheumatology, Department of Microbiology and Immunology , Temple University School of Medicine , Philadelphia, Pennsylvania , USA.
authors.forename: Phillip
authors.initials: P
authors.lastname: Cohen
authors.affiliation: Clinical Pharmacology Research Program , Oklahoma Medical Research Foundation , Oklahoma City, Oklahoma , USA.
authors.forename: Joan T
authors.initials: JT
authors.lastname: Merrill
authors.affiliation: Department of Medicine , Medical University of South Carolina, Medical Research Service, Ralph H. Johnson VAMC , Charleston, South Carolina , USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Gilkeson
authors.affiliation: Systemic Autoimmunity Branch , National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland , USA.
authors.forename: Mariana
authors.initials: M
authors.lastname: Kaplan
authors.affiliation: Department of Arthritis and Clinical Immunology , Oklahoma Medical Research Foundation , Oklahoma City, Oklahoma , USA.
authors.forename: Judith
authors.initials: J
authors.lastname: James
authors.affiliation: Department of Internal Medicine , University of Michigan Health System , Ann Arbor, Michigan , USA.
authors.forename: W Joseph
authors.initials: WJ
authors.lastname: McCune
authors.affiliation: Divisions of Rheumatology and Clinical Epidemiology , McGill University Health Centre , Montreal, Quebec , Canada.
authors.forename: Sasha
authors.initials: S
authors.lastname: Bernatsky
authors.affiliation: Departments of Medicine and Immunology , University of Washington , Seattle, Washington , USA.
authors.forename: Keith
authors.initials: K
authors.lastname: Elkon
keywords: Autoimmunity; Disease Activity; Inflammation; Lupus Nephritis; Systemic Lupus Erythematosus