title: Which Patient Characteristics Among Cocaine Users with HIV Relate to Drug Use and Adherence Outcomes Following a Dual-Focused Intervention?
abstract: This is a secondary analysis of data from a randomized trial of dually-focused interventions for nonadherent HIV patients with cocaine use disorders (Ingersoll et al. in Drug Alcohol Depend 116(1-3):177-187, 2011). We examined the relationships among baseline demographic, psychological, psychiatric, and behavioral characteristics and 6-months post-study ART adherence, log viral load (VL), ASI Drug Composite Score, and days using cocaine. We used the SAS GLMSELECT procedure to build multivariate models of each post-study outcome. Post-study ART adherence was related to 2 psychological variables; while logVL was related to 2 drug-related behaviors. ASI Drug Composite score was related to 2 psychiatric disorders, 1 demographic, and 1 psychological variable; in contrast, days using cocaine related to 1 behavioral and 3 psychological variables. Analyses show clear, robust relationships among behavioral, psychological and psychiatric diagnosis factors with post-study ART adherence and cocaine use outcomes. Future ART adherence interventions for cocaine users should consider tailoring to these patient characteristics.
authors.affiliation: Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, 310 Old Ivy Way, Suite 102, Charlottesville, VA, 22903, USA.
authors.forename: Gaia
authors.initials: G
authors.lastname: Read
authors.affiliation: Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, 310 Old Ivy Way, Suite 102, Charlottesville, VA, 22903, USA. kareningersoll@virginia.edu.
authors.forename: Karen S
authors.initials: KS
authors.lastname: Ingersoll
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D019970:Cocaine-Related Disorders / Q000453:epidemiology* / Q000523:psychology / Q000628:therapy; D016578:Crack Cocaine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012959:Socioeconomic Factors; D016896:Treatment Outcome; D016903:Drug Monitoring
chemical_list: D044966:Anti-Retroviral Agents; D016578:Crack Cocaine
keywords: ART adherence; Crack cocaine; Patient characteristics