title: Quantitative simultaneous positron emission tomography and magnetic resonance imaging.
abstract: Simultaneous positron emission tomography and magnetic resonance imaging (PET-MR) is an innovative and promising imaging modality that is generating substantial interest in the medical imaging community, while offering many challenges and opportunities. In this study, we investigated whether MR surface coils need to be accounted for in PET attenuation correction. Furthermore, we integrated motion correction, attenuation correction, and point spread function modeling into a single PET reconstruction framework. We applied our reconstruction framework to in vivo animal and patient PET-MR studies. We have demonstrated that our approach greatly improved PET image quality.
authors.affiliation: Massachusetts General Hospital , Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, Massachusetts 02114, United States ; Harvard Medical School , Department of Radiology, Boston, Massachusetts 02114, United States.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ouyang
authors.affiliation: Massachusetts General Hospital , Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, Massachusetts 02114, United States ; Sorbonne Universités , UPMC Univ Paris 06, Paris 75634, France.
authors.forename: Yoann
authors.initials: Y
authors.lastname: Petibon
authors.affiliation: Massachusetts General Hospital , Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, Massachusetts 02114, United States ; Harvard Medical School , Department of Radiology, Boston, Massachusetts 02114, United States.
authors.forename: Chuan
authors.initials: C
authors.lastname: Huang
authors.affiliation: Harvard Medical School , Department of Radiology, Boston, Massachusetts 02114, United States ; Massachusetts General Hospital , Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, United States.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Reese
authors.affiliation: Massachusetts General Hospital , Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, Massachusetts 02114, United States.
authors.forename: Aleksandra L
authors.initials: AL
authors.lastname: Kolnick
authors.affiliation: Massachusetts General Hospital , Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, Massachusetts 02114, United States ; Harvard Medical School , Department of Radiology, Boston, Massachusetts 02114, United States.
authors.forename: Georges
authors.initials: G
authors.lastname: El Fakhri
keywords: motion correction; point spread function modeling; positron emission tomography and magnetic resonance imaging; positron emission tomography attenuation correction; surface coils