title: Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer.
abstract: Biocomposite scaffolds of lithium (Li)-containing mesoporous bioglass and monomethoxy poly(ethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine) (mPEG-PLGA-b-PLL) copolymer were fabricated in this study. The results showed that the water absorption and degradability of Li-containing mesoporous bioglass/mPEG-PLGA-b-PLL composite (l-MBPC) scaffolds were obviously higher than Li-containing bioglass/mPEG-PLGA-b-PLL composite (l-BPC) scaffolds. Moreover, the apatite-formation ability of l-MBPC scaffolds was markedly enhanced as compared with l-BPC scaffolds, indicating that l-MBPC scaffolds containing mesoporous bioglass exhibited good bioactivity. The cell experimental results showed that cell attachment, proliferation, and alkaline phosphatase activity of MC3T3-E1 cells on l-MBPC scaffolds were remarkably improved as compared to l-BPC scaffolds. In animal experiments, the histological elevation results revealed that l-MBPC scaffolds significantly promoted new bone formation, indicating good osteogenesis. l-MBPC scaffolds with improved properties would be an excellent candidate for bone tissue repair.
authors.affiliation: The College of Basic Science of Medicine, Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Lieping
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: An
authors.affiliation: School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Ji
authors.affiliation: Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Niu
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects*; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D011091:Polyesters; C574222:monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine); D011107:Polylysine; D011092:Polyethylene Glycols; D008094:Lithium
keywords: MBG; bioactivity; bone repair; cell proliferation; copolymer; degradability; osteogenesis