title: IL-17C is required for lethal inflammation during systemic fungal infection.
abstract: Within the interleukin-17 (IL-17) family of cytokines, IL-17A is known to be critical in the host defense against fungal infections; however, the function of the other IL-17 family members in anti-fungal immunity remains largely unknown. Here, we show that IL-17C expression was highly induced in kidney epithelial cells after fungal infection. Mice that lacked IL-17C exhibited increased survival and attenuated kidney tissue damage, although they had similar fungal loads. IL-17C deficiency resulted in decreased pro-inflammatory cytokine expression compared with wild-type control mice. Additionally, IL-17C directly acted on renal epithelial cells in vitro to promote pro-inflammatory cytokine production. Taken together, our data demonstrate that IL-17C is a critical factor that potentiates inflammatory responses and causes host injury during fungal infection.
authors.affiliation: Institute for Immunology, Tsinghua University, Beijing, 100084, China.
authors.forename: Jinling
authors.initials: J
authors.lastname: Huang
authors.affiliation: Institute for Immunology, Tsinghua University, Beijing, 100084, China.
authors.forename: Shaoshuai
authors.initials: S
authors.lastname: Meng
authors.affiliation: Institute for Immunology, Tsinghua University, Beijing, 100084, China.
authors.forename: Shanjuan
authors.initials: S
authors.lastname: Hong
authors.affiliation: Institute for Immunology, Tsinghua University, Beijing, 100084, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lin
authors.affiliation: Institute for Immunology, Tsinghua University, Beijing, 100084, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.affiliation: Institute for Immunology, Tsinghua University, Beijing, 100084, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology*; D018836:Inflammation Mediators / Q000378:metabolism; D020381:Interleukin-17 / Q000172:deficiency / Q000378:metabolism*; D007668:Kidney / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008810:Mice, Inbred C57BL; D009181:Mycoses / Q000276:immunology* / Q000382:microbiology*; D016019:Survival Analysis
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D020381:Interleukin-17