title: Analysis of AC3-33 gene expression in multiple organ cancer and adjacent normal tissue by RNAin situhybridization.
abstract: TheAC3-33gene encodes a secretory protein that can inhibit Elk1 transcriptional activity via the ERK1/2 pathway. In the current study,in situRNA hybridization was used to detect theAC3-33gene expression in multiple organ cancer and cancer-adjacent normal tissue. The results showed that the expression level ofAC3-33varies across different tissues.AC3-33exhibited positive expression in squamous cell carcinoma of the esophagus, adenocarcinoma of the rectum, hepatocellular carcinoma, squamous cell carcinoma (SCC) of the lung, cancer-adjacent normal hepatic tissue, clear cell carcinoma of the kidney, invasive ductal carcinoma of the breast, SCC of the uterine cervix and cancer-adjacent normal kidney tissue. Negative expression ofAC3-33was observed in adenocarcinoma of the stomach and colon, cancer-adjacent normal esophageal tissue, cancer-adjacent normal gastric tissue, cancer-adjacent normal colon tissue, cancer-adjacent normal rectal tissue, serous adenocarcinoma of the ovary and cancer-adjacent normal ovarian tissue. However, the expression ofAC3-33in cancer adjacent normal breast tissue was partially positive. In conclusion, theAC3-33gene does exhibit positive expression in certain carcinomas, which may indicate thatAC3-33has a significant involvement in the development and progression of these carcinomas.
authors.affiliation: College of Life Sciences, College of Psychology, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Hu
authors.affiliation: College of Life Sciences, College of Psychology, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Yang
authors.affiliation: College of Life Sciences, College of Psychology, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Lv
authors.affiliation: College of Life Sciences, College of Psychology, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Environment and Chemical Engineering, Tangshan College, Tangshan, Hebei 063000, P.R. China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Meng
authors.affiliation: College of Life Sciences, College of Psychology, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Gou
authors.affiliation: College of Life Sciences, College of Psychology, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Xiujun
authors.initials: X
authors.lastname: Zhang
keywords: AC3-33; RNA in situ hybridization; cancer