title: Plausible etiology of brain dysconnectivity in autism - Review and prospectus.
abstract: This report summarizes recent findings related to the neuropathology of autism. Combining the relevant observations assessed here, a comprehensive, coherent hypothesis explaining the etiology of juvenile autism may be deduced. This proposed mechanism describes a process initiated by insulin-like growth factor deficiency, resulting in brain dysconnectivity as central to the behavioral manifestations of this disease.
authors.affiliation: Clinical Adjunct Professor of Biochemistry and Obstetrics/Gynecology, Touro College of Osteopathic Medicine, 230 West 125th St., New York, NY 10017, USA. Electronic address: DAV4601@aol.com.
authors.forename: Gary
authors.initials: G
authors.lastname: Steinman
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*; D001369:Axons / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003712:Dendrites / Q000502:physiology; D004200:Diseases in Twins; D006801:Humans; D007223:Infant; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D051379:Mice; D009474:Neurons / Q000378:metabolism; D011110:Polymorphism, Genetic; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology
chemical_list: D007334:Insulin-Like Growth Factor I