title: Epidemiology of multiple sclerosis in the pediatric population of Sardinia, Italy.
abstract: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Several authors report MS affecting not only young adults but also children and adolescents. Sardinia is one of the regions at the highest risk for MS worldwide in the adult population; to date, no definite data exist on the pediatric population. The aim of this study was to estimate the incidence and prevalence of pediatric MS (pMS) in northern Sardinia. Patients with diagnosis of optic neuritis, myelitis, acute disseminated encephalomyelitis (ADEM), demyelinating disorders, MS, or clinically isolated syndrome (CIS) according to McDonald criteria were enrolled, when disease onset occurred within the range of 0-18 years. From January 1, 2001 to December 31, 2012, 21 cases of pMS and 5 cases of CIS were found in northern Sardinia. The annual mean pMS incidence was 2.85 cases per 100,000 pediatric population, and the annual mean CIS incidence was 0.68 cases per 100,000 pediatric population. The pMS and CIS prevalence computed on 31 December 2012 was 26.92 and 6.41 per 100,000 pediatric population, respectively.
  
  
  CONCLUSIONS
  Our pMS data among Sardinians corroborate the epidemiological scenario described in the adult population being the incidence estimates significantly higher than those reported elsewhere.
  
  
  BACKGROUND
  Sardinia is one of the regions at the highest risk for MS worldwide in the adult population. To date, no definite data exist on the pediatric population.
  
  
  BACKGROUND
  The pediatric MS incidence in Sardinia is estimated to be significantly higher than those reported elsewhere. The pediatric MS prevalence in Sardinia is among the highest values worldwide.
authors.affiliation: Department of Clinical and Experimental Medicine, Section of Child Neuropsychiatry, University of Sassari, Sassari, Italy. silviagem85@hotmail.it.
authors.forename: Silvia
authors.initials: S
authors.lastname: Dell'Avvento
authors.affiliation: Department of Biomedical Sciences, Human Anatomy, University of Sassari, Sassari, Italy. asotgiu@uniss.it.
authors.forename: Maria Alessandra
authors.initials: MA
authors.lastname: Sotgiu
authors.affiliation: Unit of Neuropsychiatry for Infants and Adolescents (UONPIA), ASL 1, Sassari, Italy. icamanca@yahoo.it.
authors.forename: Salvatorica
authors.initials: S
authors.lastname: Manca
authors.affiliation: Department of Biomedical Sciences, Clinical Epidemiology and Medical Statistics Unit, University of Sassari, Sassari, Italy. gsotgiu@uniss.it.|Research, Medical Education and Professional Development Unit, AOU Sassari, Sassari, Italy. gsotgiu@uniss.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sotgiu
authors.affiliation: Department of Clinical and Experimental Medicine, Section of Child Neuropsychiatry, University of Sassari, Sassari, Italy. stefanos@uniss.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Sotgiu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology*; D015995:Prevalence
keywords: Children; Clinically isolated syndrome; Incidence; Multiple sclerosis; Prevalence; Sardinia