title: Chromogranin A levels and mortality in patients with severe sepsis.
abstract: BACKGROUND
  Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.
  
  
  OBJECTIVE
  Assess association of CgA levels and mortality risk of severely septic patients.
  
  
  METHODS
  Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.
  
  
  RESULTS
  Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.
  
  
  CONCLUSIONS
  High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
authors.affiliation: a University of Texas Health Science Center San Antonio , San Antonio , TX, USA .
authors.forename: Chih-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Luis F
authors.initials: LF
authors.lastname: Reyes
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Orihuela
authors.forename: Ricardo
authors.initials: R
authors.lastname: Buitrago
authors.forename: Antonio
authors.initials: A
authors.lastname: Anzueto
authors.forename: Nilam J
authors.initials: NJ
authors.lastname: Soni
authors.forename: Stephanie
authors.initials: S
authors.lastname: Levine
authors.forename: Jay
authors.initials: J
authors.lastname: Peters
authors.forename: Cecilia A
authors.initials: CA
authors.lastname: Hinojosa
authors.forename: Stefano
authors.initials: S
authors.lastname: Aliberti
authors.forename: Oriol
authors.initials: O
authors.lastname: Sibila
authors.forename: Alejandro
authors.initials: A
authors.lastname: Rodriguez
authors.forename: James D
authors.initials: JD
authors.lastname: Chalmers
authors.forename: Ignacio
authors.initials: I
authors.lastname: Martin-Loeches
authors.forename: Jose
authors.initials: J
authors.lastname: Bordon
authors.forename: Jose
authors.initials: J
authors.lastname: Blanquer
authors.forename: Francisco
authors.initials: F
authors.lastname: Sanz
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Marcos
authors.forename: Jordi
authors.initials: J
authors.lastname: Rello
authors.forename: Jordi
authors.initials: J
authors.lastname: Solé-Violán
authors.forename: Marcos I
authors.initials: MI
authors.lastname: Restrepo
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D053379:Chromogranin A / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D018805:Sepsis / Q000097:blood / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D053379:Chromogranin A
keywords: Biological marker; Chromogranin A; cardiovascular diseases; mortality; sepsis