title: Biofunctional properties of Eruca sativa Miller (rocket salad) hydroalcoholic extract.
abstract: Eruca sativa Miller is a worldwide common alimentary plant (rocket leaves). The aim of this study was to correlate the potential in vitro scavenging activity of the E. sativa hydroalcoholic extract (HAE) with its in vivo hypoglycaemic effect. In DDPH free radical (DFR) and ferric-reducing antioxidant power assays, HAE in a concentration dependent manner (25-100 μg/mL) displayed a strong scavenging activity with maximum effect of 88% and 75% at 100 μg/mL, respectively. Daily administration of HAE (50 mg/kg; p.o.) in the in vivo model of alloxan-induced diabetic rabbits for 28 days showed significant reduction in glycaemia, also supported by recovery of body weight. In conclusion, our results give preliminary information on the potential use of this plant as a nutraceutical, useful to control and/or prevent a hyperglycaemic status.
authors.affiliation: a Department of Chemistry , Kohat University of Science and Technology , Kohat , Pakistan.
authors.forename: Khushbakht
authors.initials: K
authors.lastname: Sultan
authors.affiliation: a Department of Chemistry , Kohat University of Science and Technology , Kohat , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zakir
authors.affiliation: b Department of Pharmacy , Abdul Wali Khan University Mardan , Mardan 23200 , Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: c Institute of Chemical Sciences, University of Peshawar , Peshawar , KPK 25120 , Pakistan.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.affiliation: d Department of Zoology , Kohat University of Science and Technology , Kohat , Pakistan.
authors.forename: Noor Ul
authors.initials: NU
authors.lastname: Akber
authors.affiliation: a Department of Chemistry , Kohat University of Science and Technology , Kohat , Pakistan.
authors.forename: Murad Ali
authors.initials: MA
authors.lastname: Khan
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D019607:Brassicaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D011817:Rabbits
chemical_list: D001786:Blood Glucose; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan
keywords: Eruca sativa Miller; antioxidant; hypoglycaemic activity; rocket salad