title: Efficacy of oxitard capsules in the treatment of oral submucous fibrosis.
abstract: OBJECTIVE
  Oral submucous fibrosis (OSMF) is a high-risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to evaluate the efficacy of oxitard capsules in the management of OSMF.
  
  
  METHODS
  Total of 120 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups; Group A (oxitard group) and Group B (placebo group). Group A was administered 2 oxitard capsules twice daily and Group B was given placebo tablets twice daily, for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Student's paired t test and Chi-square test. P < 0.001 was considered to be statistically significant.
  
  
  RESULTS
  Clinical improvements in mouth-opening and tongue protrusion were significant in the Group A (P < 0.001). Subjective symptoms of burning sensation (P = 0.0001), pain associated with the lesion (P = 0.000), difficulty in swallowing (P = 0.0003) and speech (P = 0.0005) also significantly improved in the Group A. There was a mild to moderate decrease in the size of the lesion.
  
  
  CONCLUSIONS
  Though there is no definitive treatment for the condition; however, oxitard capsules can bring about significant clinical improvements in the symptoms like mouth-opening, tongue protrusion, burning sensation, difficulty in swallowing and speech and pain associated with the lesion, thereby improving the quality of life of the affected individuals.
authors.affiliation: Department of Oral Medicine and Radiology, Chattisgarh Dental College and Research Institute, Rajnandgaon, Chattisgarh, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Patil
authors.forename: B S
authors.initials: BS
authors.lastname: Santosh
authors.forename: Sneha
authors.initials: S
authors.lastname: Maheshwari
authors.forename: Abhijeet
authors.initials: A
authors.lastname: Deoghare
authors.forename: Satish
authors.initials: S
authors.lastname: Chhugani
authors.forename: P R
authors.initials: PR
authors.lastname: Rajesh
mesh_terms: D000328:Adult; D002214:Capsules; D005260:Female; D006801:Humans; D008297:Male; D009914:Oral Submucous Fibrosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002214:Capsules; D010936:Plant Extracts