title: Left atrial appendage isolation using percutaneous (endocardial/epicardial) devices: Pre-clinical and clinical experience.
abstract: Atrial fibrillation (AF) is the most common arrhythmia in the elderly population and it is associated with a four-fold to five-fold increased risk of thromboembolic events. It was not until the mid-1950s that the left atrial appendage (LAA) was identified as the main location of thrombus formation, particularly in patients with non-valvular AF. In this review, we explain at some extent its embryology, anatomy and physiology, and as well as the clinical and pre-clinical trials published to date testing the safety and efficacy of most LAA closure devices. Among those devices, the most studied include the PLAATO system (ev3 Endovascular, Plymouth, MN), the Amplatzer cardiac plug (St Jude, Golden Valley, MN; St. Jude Medical, Minneapolis, MN), the WATCHMAN device (Boston Scientific, Plymouth, MN; Atritech Inc., Plymouth, MN), and the LARIAT device (SentreHEART, Palo Alto, CA). Similarly, newer LAA closure devices currently under investigation such as the Transcatheter Patch (Custom Medical Devices, Athens, Greece), AEGIS, and the Coherex WaveCrest (Salt Lake City, UT) will also be discussed. Future perspectives and the need for well-designed prospective studies between devices and new oral anticoagulant drugs are also proposed.
authors.affiliation: Montefiore Medical Center, Albert Einstein College of Medicine, Montefiore-Einstein Center for Heart & Vascular Care, Bronx, NY; Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Department of Medicine, Division of Cardiology/Electrophysiology, Los Angeles, CA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Romero
authors.affiliation: Texas Cardiac Arrhythmia Institute at St. David׳s Medical Center, Austin, TX; Department of Biomedical Engineering, University of Texas, Austin, TX; Division of Cardiology, Stanford University, Palo Alto, CA; Case Western Reserve University, Cleveland, OH; Scripps Clinic, San Diego, CA; Dell Medical School, Austin, TX.
authors.forename: Andrea
authors.initials: A
authors.lastname: Natale
authors.affiliation: Montefiore Medical Center, Albert Einstein College of Medicine, Montefiore-Einstein Center for Heart & Vascular Care, Bronx, NY.
authors.forename: Krysthel
authors.initials: K
authors.lastname: Engstrom
authors.affiliation: Montefiore Medical Center, Albert Einstein College of Medicine, Montefiore-Einstein Center for Heart & Vascular Care, Bronx, NY; Texas Cardiac Arrhythmia Institute at St. David׳s Medical Center, Austin, TX; Department of Biomedical Engineering, University of Texas, Austin, TX; Department of Cardiology, University of Foggia, Foggia, Italy. Electronic address: dibbia@gmail.com.
authors.forename: Luigi
authors.initials: L
authors.lastname: Di Biase
mesh_terms: D000925:Anticoagulants / Q000145:classification / Q000494:pharmacology; D020517:Atrial Appendage / Q000196:embryology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D001281:Atrial Fibrillation / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods; D006325:Heart Atria; D006801:Humans; D053831:Surgical Fixation Devices / Q000145:classification*; D013927:Thrombosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants