title: Involvement of epithelial Wntless in the regulation of postnatal hair follicle morphogenesis.
abstract: The roles of the Wnt cargo receptor Wntless (Wls) during hair follicle (HF) induction and postnatal HF cycling in skin have been elucidated. However, whether Wls regulates postnatal HF morphogenesis remains unclear. In this study, we found that Wls is expressed in developing HF during the morphogenesis stage after birth. By knocking out Wls in mouse skin epithelia with hypomorphic K14-cre, we found that Wls is required for normal HF morphogenesis. Wls-deficient HFs prematurely regressed, which was possibly caused by abnormally activated TGF-β/JNK pathway. Although Wls was reported to be a direct target of the Wnt/β-catenin pathway, we found that epithelial β-catenin was not necessary to maintain Wls expression. Therefore, other signals are involved in regulating Wls transcription in mouse skin.
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
authors.forename: Sixia
authors.initials: S
authors.lastname: Huang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
authors.forename: Xuming
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
authors.forename: Baojie
authors.initials: B
authors.lastname: Li
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China. xzguo2005@gmail.com.
authors.forename: Xizhi
authors.initials: X
authors.lastname: Guo
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China. magang2004@gmail.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Ma
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics; D018859:Hair Follicle / Q000254:growth & development*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000378:metabolism; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000235:genetics*; D051176:beta Catenin / Q000235:genetics
chemical_list: C545200:Gpr177 protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins; D051176:beta Catenin; D048031:JNK Mitogen-Activated Protein Kinases
keywords: Hair follicle; TGF-β; Wntless; Β-catenin