title: Contrasting network and modular perspectives on inhibitory control.
abstract: A prominent theory proposes that the right inferior frontal cortex of the human brain houses a dedicated region for motor response inhibition. However, there is growing evidence to support the view that this inhibitory control hypothesis is incorrect. Here, we discuss evidence in favour of our alternative hypothesis, which states that response inhibition is one example of a broader class of control processes that are supported by the same set of frontoparietal networks. These domain-general networks exert control by modulating local lateral inhibition processes, which occur ubiquitously throughout the cortex. We propose that to fully understand the neural basis of behavioural control requires a more holistic approach that considers how common network mechanisms support diverse cognitive processes.
authors.affiliation: The Computational, Cognitive and Clinical Neuroimaging Laboratory, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. Electronic address: a.hampshire@imperial.ac.uk.
authors.forename: Adam
authors.initials: A
authors.lastname: Hampshire
authors.affiliation: The Computational, Cognitive and Clinical Neuroimaging Laboratory, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. Electronic address: david.sharp@imperial.ac.uk.
authors.forename: David J
authors.initials: DJ
authors.lastname: Sharp
mesh_terms: D001921:Brain / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*
keywords: attention; cognitive control; fMRI; intrinsic connectivity networks; neural modules; response inhibition