title: Evaluation on bioactivities of total flavonoids from Lavandula angustifolia.
abstract: Lavandula angustifolia was used to treat flus and fevers, joint swelling and pain in Uighur medicine. This study aimed to investigate antioxidant, antit anti-inflammatory and antalgic noids content (530.1mg/g rutin/g dry extract) with stronger DPPH scavenging abilities and reduciactivities of total flavonoids from Lavandula angustifolia (LTF). Results indicated that LTF possesses the highest total flavong power. Some flavonoids separated from LTF, and their DPPH scavenging abilities as follows: rosmarinic acid (2, near to Vit C) >luteolin (3) >apigenin (4) >luteolin 7-O-β-D-glucoside (5) >apigenin 7-O-β-D-glucoside (6) >luteolin 7-O-β-D-glucuronide (7). LTF significantly decreased malondialdehyde (MDA) level in D-galactose induced aging model compared to the control group (P<0.05), as well as significantly increased plasma superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities (P<0.05). Moreover, 17.4, 34.8 and 69.6 mg/kg doses of LTF were exhibited signiﬁcant analgesic and anti-inﬂammatory activities in a dose dependent manner (P<0.05). Cytotoxicity of LTF on Bel-7402 and Hela cell lines were showed by MTT assay also. These results verified traditional usage of this plant and suggested also that LTF is worth developing and studying further.
authors.affiliation: College of Public Health, Xinjiang Medical University, Urumqi, China / Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Xu
authors.affiliation: Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
authors.forename: Tengfei
authors.initials: T
authors.lastname: Ji
authors.affiliation: Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, China.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Li
authors.affiliation: Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Public Health, Xinjiang Medical University, Urumqi, China.
authors.forename: Long
authors.initials: L
authors.lastname: Ma
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D027523:Lavandula / Q000737:chemistry*; D051379:Mice
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D016166:Free Radical Scavengers