title: Voice- and swallow-related quality of life in idiopathic Parkinson's disease.
abstract: OBJECTIVE
  This study explores whether changes in voice- and swallow-related QoL are associated with progression of idiopathic Parkinson's disease (IPD). Furthermore, it examines the relationship between patients' perception of both voice and swallowing disorders in IPD.
  
  
  METHODS
  Prospective clinical study, quality of life (QoL).
  
  
  METHODS
  One-hundred mentally competent IPD patients with voice and swallowing complaints were asked to answer four QoL questionnaires (Voice Handicap Index, MD Anderson Dysphagia Inventory, Visual Analog Scale [VAS] voice, and Dysphagia Severity Scale [DSS]). Differences in means for the QoL questionnaires and their subscales within Hoehn and Yahr stage groups were calculated using one-way analysis of variance. The relationship between voice- and swallow-related QoL questionnaires was determined with the Spearman correlation coefficient.
  
  
  RESULTS
  Scores on both voice and swallow questionnaires suggest an overall decrease in QoL with progression of IPD. A plateau in QoL for VAS voice and the DSS was seen in the early Hoehn and Yahr stages. Finally, scores on voice-related QoL questionnaires were significantly correlated with swallow-related QoL outcomes.
  
  
  CONCLUSIONS
  Voice- and swallow-related QoL decreases with progression of IPD. A significant association was found between voice- and swallow-related QoL questionnaires. Healthcare professionals can benefit from voice- and swallow-related QoL questionnaires in a multidimensional voice- or swallow-assessment protocol. The patient's perception of his/her voice and swallowing disorders and its impact on QoL in IPD should not be disregarded.
  
  
  METHODS
  2b.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
authors.forename: Michel R A
authors.initials: MR
authors.lastname: van Hooren
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
authors.forename: Laura W J
authors.initials: LW
authors.lastname: Baijens
authors.affiliation: Department of Methodology and Statistics, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands.
authors.forename: Rein
authors.initials: R
authors.lastname: Vos
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
authors.forename: Walmari
authors.initials: W
authors.lastname: Pilz
authors.affiliation: Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: Laura M F
authors.initials: LM
authors.lastname: Kuijpers
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
authors.forename: Bernd
authors.initials: B
authors.lastname: Kremer
authors.affiliation: Centre for Gastrointestinal Sciences, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Sciences Centre, Salford Royal Hospital, Salford, United Kingdom.
authors.forename: Emilia
authors.initials: E
authors.lastname: Michou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003679:Deglutition / Q000502:physiology*; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014831:Voice / Q000502:physiology*; D014833:Voice Quality
keywords: Parkinson's disease; dysphagia; dysphonia; quality of life; voice