title: [Evaluation of N2O inhalation and oral midazolam conscious sedation in pediatric dentistry of children with intellectual disability].
abstract: OBJECTIVE
  To evaluate the effect of N2O inhalation and oral midazolam sedation on uncooperative patients with intellectual disability in pediatric dentistry.
  
  
  METHODS
  N2O inhalation (35%-50%) and oral midazolam conscious sedation (dosages range: 0.50-0.75 mg/kg) were applied to 67 uncooperative pediatric patients with intellectual disability in outpatient department. The patients were divided into 2 groups: group A (N2O inhalation conscious sedation) and group B(oral midazolam conscious sedation).Treatment results and safety were statistically analyzed by Chi-square test with SPSSl3.0 software package.
  
  
  RESULTS
  The mean success rate was 70%. The success rate in group B (75%) was higher than group A (67%). The overall incidence of adverse reactions was 13%(9/67). The adverse reaction rate in group B (25%) was significantly higher than group A (5%, P<0.05).
  
  
  CONCLUSIONS
  N2O inhalation and oral midazolam conscious sedation are effective and safe in pediatric dental uncooperative patients with intellectual disability.
authors.affiliation: Hangzhou Stomatological Hospital. Hangzhou 313000, Zhejiang Province, China.E-mail:15167134798@163.com.
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Tian
authors.forename: Yan-zhong
authors.initials: YZ
authors.lastname: Yang
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Li
mesh_terms: D000280:Administration, Inhalation; D002648:Child; D016292:Procedural Sedation; D006801:Humans; D008607:Intellectual Disability; D008874:Midazolam; D009589:Nitrogen Oxides; D010377:Pediatric Dentistry
chemical_list: D009589:Nitrogen Oxides; D008874:Midazolam