title: Synthesis and Heteroannulation of Pyridine and Related Heterocyclic Systems Having Surface and Biological Activities.
abstract: Possible approaches to the synthesis of functionalized, pyrazole, isoxazole, pyrimidine, pyridine and fused pyridine derivatives The sequence involves the heterocyclization of ethyl 3-oxo-2-(4-stearamidobenzoyl)butanoate (3) with appropriate reagents. Propoxylated of these heterocycles using propylene oxide to produce nonionic surface active agents having a long alkyl chain with molecular weight suitable for becoming an amphiphilic molecule with correct hydrophilic-lypophilic balance which enhances solubility, biodegradability and hence lowers the toxicity to human beings and becomes environmentally friendly. The antimicrobial activity of the newly synthesized was examined and it was found that some of these compounds have similar or higher activity compared with commercial antibiotic drugs (sulphadiazine), which make them suitable for diverse applications like the manufacturing of drugs, pesticides, emulsifiers, cosmetics, etc.
authors.affiliation: Chemistry Department, College of Applied Sciences, Umm Al-Qura University.
authors.forename: Refat
authors.initials: R
authors.lastname: El-Sayed
mesh_terms: D000090:Acetoacetates / Q000737:chemistry; D001673:Biodegradation, Environmental; D003500:Cyclization; D004352:Drug Resistance, Microbial; D004852:Epoxy Compounds / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007202:Indicators and Reagents / Q000737:chemistry; D008970:Molecular Weight; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000090:Acetoacetates; D004852:Epoxy Compounds; D007202:Indicators and Reagents; D011725:Pyridines; D013501:Surface-Active Agents; C024840:ethyl acetoacetate; C009068:propylene oxide