title: Overexpression of Lysine-Specific Demethylase 1 Is Associated With Tumor Progression and Unfavorable Prognosis in Chinese Patients With Endometrioid Endometrial Adenocarcinoma.
abstract: OBJECTIVE
  Lysine-specific demethylase 1 (LSD1) is a kind of flavin adenine dinucleotide-dependent amine oxidase that regulates normal cellular differentiation, gene activation, tumorigenesis, and progression. This study aims to detect the expression level of LSD1 in endometrial cancer and to explore its role in the progression and prognosis of endometrioid endometrial adenocarcinoma (EEA).
  
  
  METHODS
  Immunohistochemistry was used to examine the expression of LSD1 in 206 EEA specimens, 50 benign endometrial lesion specimens, and 45 normal endometrium specimens. χ Analysis, Kaplan-Meier method, and multivariate Cox proportional hazard analysis were applied for the statistical analysis.
  
  
  RESULTS
  Compared with normal endometrium and benign endometrial lesion (both P < 0.001), LSD1 was overexpressed in EEA. LSD1 expression was correlated with histological grade, International Federation of Gynecology and Obstetrics (FIGO) stage, vascular/lymphatic invasion, depth of myometrial invasion, and lymph node metastasis. Results of the Kaplan-Meier analysis indicated that LSD1 expression was associated with overall survival (OS) and disease-free survival (DFS) of EEA. The negative expression LSD1 group had longer OS and DFS than did the positive expression group. The difference was significant (both P < 0.001, log-rank test). Multivariate Cox regression analysis revealed that the LSD1 expression status was an independent prognostic factor for both OS (P = 0.027) and DFS (P = 0.016) of patients with EEA.
  
  
  CONCLUSIONS
  Overexpression of LSD1 may contribute to the progression of EEA and may thus serve as a new biomarker to predict the prognosis of EEA.
authors.affiliation: *Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University; †Department of General Surgery, Heilongjiang Provincial Hospital; and ‡Department of Breast Surgery, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
authors.forename: Yun-Duo
authors.initials: YD
authors.lastname: Liu
authors.forename: Meng
authors.initials: M
authors.lastname: Dai
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Xiao
authors.forename: Fan-Ling
authors.initials: FL
authors.lastname: Meng
authors.forename: Xiu-Wei
authors.initials: XW
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018269:Carcinoma, Endometrioid / Q000175:diagnosis / Q000201:enzymology* / Q000208:ethnology; D016022:Case-Control Studies; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000208:ethnology; D005260:Female; D005500:Follow-Up Studies; D056466:Histone Demethylases / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D056466:Histone Demethylases; C495195:KDM1A protein, human