title: Hypofibrinogenemia and the α-Fibrinogen Thr312Ala Polymorphism may be Risk Factors for Early Pregnancy Loss.
abstract: We analyzed a cohort of 36 females with pregnancy loss. In addition to 11 patients with antiphospholipid antibody syndrome and 2 patients with congenital antithrombin (AT) or protein C deficiency, we identified 5 patients with low fibrinogen levels (median 110 mg/dL) prior to 10 weeks of gestation. Four of these 5 patients underwent a fibrinogen gene analysis, and all 4 were found to be heterozygotes for the α-fibrinogen (FGA) Thr321Ala polymorphism. One female without hypofibrinogenemia with a history of 8 pregnancy losses was found to be homozygous for the same polymorphism, and she also showed hypercoagulability without thrombosis. In conclusion, there was a relatively high frequency of pregnancy loss in the setting of hypofibrinogenemia and/or the FGA Thr312Ala polymorphism, and this may be an important risk factor for pregnancy loss and a hypercoagulable state in later pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kamimoto
authors.affiliation: Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan wadahide@clin.medic.mie-u.ac.jp.
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.affiliation: Central laboratory, Mie University Hospital, Mie, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ikejiri
authors.affiliation: Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Kaname
authors.initials: K
authors.lastname: Nakatani
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai City, Miyagi, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugiyama
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Osato
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Murabayashi
authors.affiliation: Department of Dermatology, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Habe
authors.affiliation: Department of Dermatology, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mizutani
authors.affiliation: Department of Blood Transfusion, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Department of Blood Transfusion, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
authors.forename: Kohshi
authors.initials: K
authors.lastname: Ohishi
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D000328:Adult; D000347:Afibrinogenemia / Q000150:complications* / Q000235:genetics; D016736:Antiphospholipid Syndrome / Q000150:complications*; D015331:Cohort Studies; D005260:Female; D005340:Fibrinogen / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D020151:Protein C Deficiency / Q000150:complications; D012307:Risk Factors
chemical_list: D005340:Fibrinogen
keywords: 
  FGA Thr312Ala; abortion; pregnancy; thrombosis