title: Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph.
abstract: A new monoterpenoid indole alkaloid compound (1) and six known monoterpenoid indole alkaloids compounds (2-7) were isolated from the barks of Voacanga africana Staph. The structures were established by spectral analysis as ibogamine-16-carboxylic acid,17,20-didehydro-5,6-dioxo-10-methoxy-methyl ester (1), voacamine (2), vobasine (3), voacangine (4), voacristine (5), 19-epi-voacristine (6) and 19-epi-heyneanine (7). Compound 1 was confirmed by X-ray crystallographic analysis. All of the isolated compounds were evaluated for cytotoxicity against five cell lines (HEPG-2, A375, MDA-MB-231, SH-SY5Y, CT26). Among them, compounds 2 and 6 displayed significant inhibitory activities, compounds 3, 4 and 5 showed moderate inhibitory activities, while compounds 1 and 7 showed no inhibitory activities against the five cell lines.
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Chen
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Yang
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Li
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Zhi-Xing
authors.initials: ZX
authors.lastname: Cao
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Dan
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Mei
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Da-Le
authors.initials: DL
authors.lastname: Guo
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Chuan-Xia
authors.initials: CX
authors.lastname: Song
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Dai
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Hu
authors.affiliation: a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Deng
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D007050:Ibogaine / Q000031:analogs & derivatives / Q000302:isolation & purification; D026121:Indole Alkaloids / Q000302:isolation & purification; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D046948:Secologanin Tryptamine Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology*; D036902:Voacanga / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D026121:Indole Alkaloids; D046948:Secologanin Tryptamine Alkaloids; C413805:ibogamine; C000611770:ibogamine-16-carboxylic acid,17,20-didehydro-5,6-dioxo-10-methoxy-methyl ester; C057239:vobasine; C005891:voacamine; D007050:Ibogaine; C012098:voacangine; C049505:voacristine
keywords: Voacanga africana Staph; cytotoxicity; monoterpenoid indole alkaloids