title: Necrotizing Scleritis, Conjunctivitis, and Other Pathologic Findings in the Left Eye and Brain of an Ebola Virus-Infected Rhesus Macaque (Macaca mulatta) With Apparent Recovery and a Delayed Time of Death.
abstract: A 3.5-year-old adult female rhesus macaque (Macaca mulatta) manifested swelling of the left upper eyelid and conjunctiva and a decline in clinical condition 18 days following intramuscular challenge with Ebola virus (EBOV; Kikwit-1995), after apparent clinical recovery. Histologic lesions with strong EBOV antigen staining were noted in the left eye (scleritis, conjunctivitis, and peri-optic neuritis), brain (choriomeningoencephalitis), stomach, proximal duodenum, and pancreas. Spleen, liver, and adrenal glands, common targets for acute infection, appeared histologically normal with no evidence of EBOV immunoreactivity. These findings may provide important insight for understanding sequelae seen in West African survivors of Ebola virus disease.
authors.affiliation: Defense Health Agency Veterinary Services, Defense Health Headquarters, Falls Church, Virginia.
authors.forename: Derron A
authors.initials: DA
authors.lastname: Alves
authors.affiliation: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick.
authors.forename: Anna N
authors.initials: AN
authors.lastname: Honko
authors.affiliation: Uniformed Services University of the Health Sciences, Bethesda.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Kortepeter
authors.affiliation: Pathology Division.
authors.forename: Mei
authors.initials: M
authors.lastname: Sun
authors.affiliation: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Johnson
authors.affiliation: Veterinary Medicine Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Lugo-Roman
authors.affiliation: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick.
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Hensley
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology* / Q000821:virology; D020805:Central Nervous System Viral Diseases / Q000209:etiology / Q000473:pathology* / Q000821:virology; D003231:Conjunctivitis / Q000209:etiology / Q000473:pathology* / Q000821:virology; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000302:isolation & purification*; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D008253:Macaca mulatta; D009336:Necrosis; D015423:Scleritis / Q000209:etiology / Q000473:pathology* / Q000821:virology
keywords: Ebola virus; Ebola virus disease; brain; delayed death; eye; intramuscular; macaque; rhesus; sequelae