title: Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading.
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Pavel
authors.initials: P
authors.lastname: Strop
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Kathy
authors.initials: K
authors.lastname: Delaria
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Davide
authors.initials: D
authors.lastname: Foletti
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Jody Melton
authors.initials: JM
authors.lastname: Witt
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Adela
authors.initials: A
authors.lastname: Hasa-Moreno
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Kris
authors.initials: K
authors.lastname: Poulsen
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Meritxell Galindo
authors.identifier: 0000000250341722
authors.initials: MG
authors.lastname: Casas
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Dorywalska
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Santiago
authors.initials: S
authors.lastname: Farias
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Ariel
authors.initials: A
authors.lastname: Pios
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Lui
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut, USA.
authors.forename: Russell
authors.initials: R
authors.lastname: Dushin
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut, USA.
authors.forename: Dahui
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut, USA.
authors.forename: Thayalan
authors.initials: T
authors.lastname: Navaratnam
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Thomas-Toan
authors.initials: TT
authors.lastname: Tran
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Janette
authors.initials: J
authors.lastname: Sutton
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Lindquist
authors.affiliation: Drug Safety Research and Development, Pfizer Inc., San Diego, California, USA.
authors.forename: Bora
authors.initials: B
authors.lastname: Han
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Liu
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Shelton
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Jaume
authors.initials: J
authors.lastname: Pons
authors.affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California, USA.
authors.forename: Arvind
authors.initials: A
authors.lastname: Rajpal
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D018796:Immunoconjugates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008958:Models, Molecular; D051381:Rats; D023041:Xenograft Model Antitumor Assays
chemical_list: D018796:Immunoconjugates