title: Influence of Eyelid Pressure on Fluorescein Staining of Ocular Surface in Dry Eyes.
abstract: OBJECTIVE
  To determine the relationship between eyelid pressure during blinking and the fluorescein staining of the cornea and conjunctiva in dry eye patients.
  
  
  METHODS
  Cross-sectional prospective study.
  
  
  METHODS
  The pressure of the upper and lower eyelids was measured with a specially designed blepahro-tensiometer in 130 eyes of 65 dry eye patients (D group) and in 58 eyes of 31 normal controls (N group). The correlations between the location and degree of ocular surface staining scores and the eyelid pressure were calculated for the D group.
  
  
  RESULTS
  The pressures of the upper and lower eyelids were significantly higher in the D group than in the N group (upper P < .0001, lower P = .0040). The lower eyelid pressure was significantly correlated with the ocular surface staining scores for the inferior cornea (r = 0.19, P = .0307) and conjunctiva (r = 0.19, P = .0252).
  
  
  CONCLUSIONS
  The significant correlation between the eyelid pressure and the ocular surface staining suggests that mechanical friction on the ocular surface by the eyelids may be one of the factors that affects the fluorescein staining of the inferior ocular surface.
authors.affiliation: Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Yoshioka
authors.affiliation: Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan; Department of Stem Cell Biology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan. Electronic address: shiraia@m.ehime-u.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiraishi
authors.affiliation: Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kono
authors.affiliation: Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Ohta
authors.affiliation: Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan; Department of Infectious Diseases, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ohashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001767:Blinking / Q000502:physiology*; D003228:Conjunctiva / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D003430:Cross-Sectional Studies; D015352:Dry Eye Syndromes / Q000378:metabolism / Q000503:physiopathology*; D005143:Eyelids / Q000503:physiopathology*; D005260:Female; D019793:Fluorescein; D005456:Fluorescent Dyes; D006801:Humans; D008297:Male; D008365:Manometry / Q000295:instrumentation; D008875:Middle Aged; D011312:Pressure; D011446:Prospective Studies; D013194:Staining and Labeling / Q000379:methods; D055815:Young Adult
chemical_list: D005456:Fluorescent Dyes; D019793:Fluorescein