title: SomaticSignatures: inferring mutational signatures from single-nucleotide variants.
abstract: Mutational signatures are patterns in the occurrence of somatic single-nucleotide variants that can reflect underlying mutational processes. The SomaticSignatures package provides flexible, interoperable and easy-to-use tools that identify such signatures in cancer sequencing data. It facilitates large-scale, cross-dataset estimation of mutational signatures, implements existing methods for pattern decomposition, supports extension through user-defined approaches and integrates with existing Bioconductor workflows.
  
  
  METHODS
  The R package SomaticSignatures is available as part of the Bioconductor project. Its documentation provides additional details on the methods and demonstrates applications to biological datasets.
  
  
  BACKGROUND
  julian.gehring@embl.de, whuber@embl.de
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany, Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA and.
authors.forename: Julian S
authors.initials: JS
authors.lastname: Gehring
authors.affiliation: European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany, Computational Genome Biology, German Cancer Research Center, 69120 Heidelberg, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Fischer
authors.affiliation: Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA and.
authors.forename: Michael
authors.initials: M
authors.lastname: Lawrence
authors.affiliation: European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Huber
mesh_terms: D015894:Genome, Human; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012984:Software