title: Sedation With Propofol Has No Effect on Capsule Endoscopy Completion Rates: A Prospective Single-Center Study.
abstract: Patients who need both capsule endoscopy (CE) and colonoscopy often undergo both examinations on the same day to avoid repeated bowel preparation and fasting. Sedation can relieve pain and is commonly used for colonoscopies but may influence the CE completion rate.To determine whether sedation with propofol influences the completion rate and small-bowel transit time (SBTT) of CE.From July 2014 to December 2014, patients (18-65 years old) who needed both CE and colonoscopy were assessed consecutively for enrollment in our study. Colonoscopies were performed with or without sedation based on patient preferences on the day of capsule ingestion. The completion rate, SBTT, and diagnostic yield of CEs were recorded. Patients' satisfaction and pain scores were also recorded.Sedation with propofol had no significant effect on CE completion rates (83.3% sedation group vs 81.8% nonsedation group, P = 0.86) but was associated with increased SBTT (403.6 ± 160.3 sedation group vs 334.5 ± 134.4 nonsedation group, P = 0.006). The diagnostic yields in the sedation and nonsedation groups were 69.4% and 65.9%, respectively (P = 0.74). The median satisfaction scores were 8.6 in the sedation group and 3.5 in the nonsedation group (P < 0.001). Median pain scores were 1.4 in the sedation group and 6.7 in the nonsedation group (P < 0.001).Sedation with propofol increased SBTT but had no effect on CE completion rates, suggesting that CE and colonoscopy with propofol can be performed on the same day (clinical trial registration number: ChiCTR-ONRC-14004866).
authors.affiliation: From the Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China (H-YG, Y-JW, W-GQ, Z-YC, Z-MX, YB, WG, T-MW, D-SP, F-CZ); Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y-SS, A-JQ); and Department of Gastroenterology, Qingyuan City People's Hospital of Jinan University, Guangdong, China (H-YG).
authors.forename: Huo-Ye
authors.initials: HY
authors.lastname: Gan
authors.forename: Yi-Jie
authors.initials: YJ
authors.lastname: Weng
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Qiao
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Chen
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Bai
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.forename: Tian-Mo
authors.initials: TM
authors.lastname: Wan
authors.forename: De-Shou
authors.initials: DS
authors.lastname: Pan
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Shi
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Qiu
authors.forename: Fa-Chao
authors.initials: FC
authors.lastname: Zhi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D053704:Capsule Endoscopy / Q000379:methods*; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D015742:Propofol