title: Left and right ventricular systolic function impairment in type 1 diabetic young adults assessed by 2D speckle tracking echocardiography.
abstract: OBJECTIVE
  Subclinical left ventricular (LV) and right ventricular (RV) systolic dysfunction has been proved in type 2 diabetes mellitus (DM). There is lack of uniform data on systolic myocardial function in type 1 DM. The aim of this study was to evaluate LV and RV function with 2D speckle tracking echocardiography (2D STE) in adult type 1 diabetic patients.
  
  
  RESULTS
  Totally, 50 patients with type 1 DM and 50 control subjects in the same range of age were prospectively evaluated. The 2D STE assessment of LV longitudinal, radial, circumferential strain and RV free-wall longitudinal strain was performed. In diabetic group, left ventricular global longitudinal strain (LVGLS), left ventricular global circumferential strain (LVGCS), left ventricular radial strain at basal level (LVRS-basal), and right ventricular free-wall global longitudinal strain (RVGLS) were significantly lower compared with the controls: LVGLS (-20.3 ± 2.0% vs. -22.2 ± 1.8%, P < 0.001), LVGCS (-21.1 ± 2.5% vs. -22.2 ± 2.4%, P < 0.05), LVRS-basal (50.5% ± 11.5 vs. 57.1% ±17.0, P < 0.05), and RVGLS (-30.1% ± 3.5 vs. -32.7% ± 3.9, P < 0.01). Multivariable logistic regression analysis showed that the only independent predictor of reduced LVGLS was low-density lipoprotein cholesterol [odds ratio 3.65 (95% confidence interval: 1.27-10.5), P = 0.014].
  
  
  CONCLUSIONS
  Type 1 DM is associated with subclinical LV systolic dysfunction and worse RV systolic function, which can be detected with 2D STE.
authors.affiliation: Department of Cardiology, Medical University of Warsaw, Brodnowski Hospital, ul. Kondratowicza 8, 03-242 Warsaw, Poland iglowka74@gmail.com.
authors.forename: Ilona
authors.initials: I
authors.lastname: Jędrzejewska
authors.affiliation: Department of Cardiology, Medical University of Warsaw, Brodnowski Hospital, ul. Kondratowicza 8, 03-242 Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Król
authors.affiliation: Department of Cardiology, Medical University of Warsaw, Brodnowski Hospital, ul. Kondratowicza 8, 03-242 Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Światowiec
authors.affiliation: Diabetes Outpatients Clinic, Medical University of Warsaw, Brodnowski Hospital, Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wilczewska
authors.affiliation: Department of Cardiology, Medical University of Warsaw, Brodnowski Hospital, ul. Kondratowicza 8, 03-242 Warsaw, Poland.
authors.forename: Iwonna
authors.initials: I
authors.lastname: Grzywanowska-Łaniewska
authors.affiliation: Department of Cardiology, Medical University of Warsaw, Brodnowski Hospital, ul. Kondratowicza 8, 03-242 Warsaw, Poland.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Dłużniewski
authors.affiliation: Department of Cardiology, Medical University of Warsaw, Brodnowski Hospital, ul. Kondratowicza 8, 03-242 Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Braksator
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D058065:Diabetic Cardiomyopathies / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000503:physiopathology
keywords: diabetic cardiomyopathy; speckle tracking echocardiography; type 1 diabetes mellitus; ventricular function