title: Design of a hyperpolarized (15)N NMR probe that induces a large chemical-shift change upon binding of calcium ions.
abstract: Ca(2+) is a fundamental metal ion for physiological functioning. Therefore, molecular probes for Ca(2+) analysis are required. Recently, a hyperpolarized NMR probe has emerged as a promising tool. Here, we report a new design of a hyperpolarized NMR probe for Ca(2+), which showed a large chemical shift change upon binding to Ca(2+) and was applied for Ca(2+) sensing in a hyperpolarized state.
authors.affiliation: Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan.
authors.forename: Ryunosuke
authors.initials: R
authors.lastname: Hata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nonaka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Takakusagi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Sando
mesh_terms: D001665:Binding Sites; D002118:Calcium / Q000032:analysis* / Q000737:chemistry*; D002413:Cations, Divalent / Q000032:analysis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes / Q000032:analysis / Q000737:chemistry*; D015394:Molecular Structure; D009587:Nitrogen Isotopes; D012015:Reference Standards
chemical_list: D002413:Cations, Divalent; D015335:Molecular Probes; D009587:Nitrogen Isotopes; D002118:Calcium