title: MRI-guided biopsies and minimally invasive therapy for prostate cancer.
abstract: Recent advances in multiparametric magnetic resonance imaging (mp-MRI) have led to a paradigm shift in the diagnosis and management of prostate cancer (PCa). Its sensitivity in detecting clinically significant cancer and the ability to localize the tumor within the prostate gland has opened up discussion on targeted diagnosis and therapy in PCa. Use of mp-MRI in conjunction with prostate-specific antigen followed by targeted biopsy allows for a better diagnostic pathway than transrectal ultrasound (TRUS) biopsy and improves the diagnosis of PCa. Improved detection of PCa by mp-MRI has also opened up opportunities for focal therapy within the organ while reducing the incidence of side-effects associated with the radical treatment methods for PCa. This review discusses the evidence and techniques for in-bore MRI-guided prostate biopsy and provides an update on the status of MRI-guided targeted focal therapy in PCa.
authors.affiliation: Joint Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Sangeet
authors.initials: S
authors.lastname: Ghai
authors.affiliation: Prostate Centre, Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Trachtenberg
keywords: Focal therapy in prostate cancer; MRI-guided prostate biopsy; multiparametric magnetic resonance imaging; prostate cancer