title: [Modulating endoplasmic reticulum stress in the treatment of cancer].
abstract: An imbalance of protein homeostasis caused by external or internal stress in the endoplasmic reticulum triggers the initiation of signalling pathways downstream of the IRE1, ATF6 and PERK sensors to a translational or transcriptional adaptive response known as UPR (Unfolded Protein Response). According to the intensity and duration of stress, the dual function of the UPR leads to either cell adaptation or cell death. UPR pathways in cancer cells are often altered and generally lead to an adaptation to an hostile environment. As the UPR becomes an emerging therapeutic target due to its increasing contribution to various diseases, we describe in this review various strategies that have been developed to discover new compounds enabling to manipulate the magnitude of ER stress in the context of cancer.
authors.affiliation: Inserm U1053, Université de Bordeaux Segalen, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France - BMYscreen, Bordeaux, France - Adresse actuelle : Inserm U916, CRLCC Institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux Cedex, France.
authors.forename: Saïd
authors.initials: S
authors.lastname: Taouji
authors.affiliation: Inserm U1053, Université de Bordeaux Segalen, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France - BMYscreen, Bordeaux, France.
authors.forename: Éric
authors.initials: É
authors.lastname: Chevet
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects*; D004722:Endoribonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D056811:Unfolded Protein Response / Q000187:drug effects; D019892:eIF-2 Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C460640:EIF2AK3 protein, human; C528229:ERN1 protein, human; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase; D004722:Endoribonucleases