title: Association between RTEL1, PHLDB1, and TREH Polymorphisms and Glioblastoma Risk: A Case-Control Study.
abstract: BACKGROUND
  Glioblastoma (GBM) is a highly invasive, aggressive, and incurable brain tumor. Genetic factors play important roles in GBM risk. The aim of this study was to elucidate the influence of gene polymorphism on GBM susceptibility.
  
  
  METHODS
  In this case-control study, we included 72 GBM patients and 320 healthy controls to analyze the association between 29 single-nucleotide polymorphisms and GBM cancer risk in the Chinese Han population. The single-nucleotide polymorphisms were determined by Sequenom MassARRAY RS1000 and statistical analysis was performed using SPSS software and SNPStats software.
  
  
  RESULTS
  Using the χ(2) test, we found that rs2297440 and rs6010620 in RTEL1 increased risk of GBM. In the recessive model, we also found that the genotypes "CC" of rs2297440 and "GG" of rs6010620 in RTEL1 significantly increased GBM risk. The variant TT genotype of TREH rs17748 and the variant TT genotype of PHLDB1 rs498872 decreased GBM risk in the recessive model. We also found that the TREH rs17748 variant C allele showed an increased risk in males in the dominant model.
  
  
  CONCLUSIONS
  Our results suggest a significant association between the RETL1, TREH, and PHLDB1 genes and GBM development in the Han Chinese population.
authors.affiliation: Department of Outpatient, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Medical, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
authors.forename: Liang
authors.initials: L
authors.lastname: Heng
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China (mainland).
authors.forename: Shuli
authors.initials: S
authors.lastname: Du
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China (mainland).
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China (mainland).
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Nursing, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
authors.forename: Hongjun
authors.initials: H
authors.lastname: Lang
authors.affiliation: Department of Outpatient, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
authors.forename: Shanqu
authors.initials: S
authors.lastname: Li
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004265:DNA Helicases / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014198:Trehalase / Q000235:genetics*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; C487973:PHLDB1 protein, human; D014198:Trehalase; C532890:RTEL1 protein, human; D004265:DNA Helicases