title: TBI-the most complex disease in the most complex organ: the CENTER-TBI trial-a commentary.
abstract: Each year, approximately 2.5 million people experience some form of traumatic brain injury (TBI) in Europe. One million of these are admitted to hospital and 75 000 will die. TBI represents a major cause of death and disability, particularly among those of working age. Substantial investments have been made in an effort to improve diagnosis, management and survival in TBI, but with little success. The Collaborative European Neuro-Trauma Effectiveness Research in TBI (CENTER-TBI) study promises to use the natural variability seen in the management of TBI across Europe with the application of Comparative Effectiveness Research (CER). It will generate repositories of baseline and comprehensive TBI patient data, neuroimaging, neurogenetics and biomarkers, which aim to improve the diagnosis, stratification, management and prognostication of patients with TBI.
authors.affiliation: Department of Anaesthesia, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: Joanna L C
authors.initials: JL
authors.lastname: Wheble
authors.affiliation: Department of Anaesthesia, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: D K
authors.initials: DK
authors.lastname: Menon
mesh_terms: D001930:Brain Injuries / Q000175:diagnosis / Q000628:therapy*; D005060:Europe; D006801:Humans; D059906:Neuroimaging; D064887:Observational Studies as Topic; D011379:Prognosis; D012042:Registries
keywords: Neurogenetics < NEUROLOGY; TRAUMA MANAGEMENT