title: Synthesis of 3-chloro-6-((4-(di-tert-butyl[(18)F]fluorosilyl)-benzyl)oxy)-1,2,4,5-tetrazine ([(18)F]SiFA-OTz) for rapid tetrazine-based (18)F-radiolabeling.
abstract: An efficient method to prepare the (18)F-labeled tetrazine-derivative [(18)F]-SiFA-OTz for bioorthogonal radiochemistry was developed. [(18)F]-SiFA-OTz can be synthesized with a radiochemical yield of 78 ± 5% within 25 min and can quantitatively react with a model strained dienophile, trans-cyclooctenol.
authors.affiliation: Department of Chemistry and Centre for Self-Assembled Chemical Structures, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 2K6, Canada. bruce.lennox@mcgill.ca.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Stephen
authors.initials: S
authors.lastname: Li
authors.forename: Carmen
authors.initials: C
authors.lastname: Wängler
authors.forename: Björn
authors.initials: B
authors.lastname: Wängler
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Lennox
authors.forename: Ralf
authors.initials: R
authors.lastname: Schirrmacher
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling; D017646:Organosilicon Compounds / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis
chemical_list: D005462:Fluorine Radioisotopes; D017646:Organosilicon Compounds; D019275:Radiopharmaceuticals