title: [The relationship between acute gastric mucosal lesions (AGML) and oxidative stress from gastric acid].
abstract: Acute gastric mucosal lesions (AGML) are primary gastrointestinal affection and many people suffer from this disease. Although there are several causes in this disease, reactive oxygen species from mitochondria (mitROS) would like to be related deeply. Surprisingly, not only non-steroidal anti-inflammatory drugs (NSAIDs) but also gastric acid with moderate pH induces mitROS, and resulted in inducing cellular apoptosis. In addition, previous our study showed manganese superoxide dismutase (MnSOD) overexpressed gastric mucosal cells, which scavenge mitROS specifically, suppressed generating lipid peroxidation attributed from mitROS and cellular death. Therefore, mitROS from NSAIDs and gastric acid are likely to cause AGML, and control of mitROS suppresses AGML and other gastrointestinal disease.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Matsui
authors.forename: Hiromu
authors.initials: H
authors.lastname: Ito
mesh_terms: D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology; D018384:Oxidative Stress; D013276:Stomach Ulcer / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal