title: Diversity, Structures, and Collagen-Degrading Mechanisms of Bacterial Collagenolytic Proteases.
abstract: Bacterial collagenolytic proteases are important because of their essential role in global collagen degradation and because of their virulence in some human bacterial infections. Bacterial collagenolytic proteases include some metalloproteases of the M9 family from Clostridium or Vibrio strains, some serine proteases distributed in the S1, S8, and S53 families, and members of the U32 family. In recent years, there has been remarkable progress in discovering new bacterial collagenolytic proteases and in investigating the collagen-degrading mechanisms of bacterial collagenolytic proteases. This review provides comprehensive insight into bacterial collagenolytic proteases, especially focusing on the structures and collagen-degrading mechanisms of representative bacterial collagenolytic proteases in each family. The roles of bacterial collagenolytic proteases in human diseases and global nitrogen cycling, together with the biotechnological and medical applications for these proteases, are also briefly discussed.
authors.affiliation: State Key Laboratory of Microbial Technology and Marine Biotechnology Research Center, Jinan, China.
authors.forename: Yu-Zhong
authors.initials: YZ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Microbial Technology and Marine Biotechnology Research Center, Jinan, China.
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Ran
authors.affiliation: State Key Laboratory of Microbial Technology and Marine Biotechnology Research Center, Jinan, China.
authors.forename: Chun-Yang
authors.initials: CY
authors.lastname: Li
authors.affiliation: State Key Laboratory of Microbial Technology and Marine Biotechnology Research Center, Jinan, China cxl0423@sdu.edu.cn.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Chen
mesh_terms: D001419:Bacteria / Q000201:enzymology*; D003094:Collagen / Q000378:metabolism*; D017364:Collagenases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014644:Genetic Variation; D006801:Humans; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D059748:Proteolysis
chemical_list: D003094:Collagen; D017364:Collagenases