title: "Edgeboost": A Novel Technique to Extend the Ablation Zone Lateral to a Two-Probe Bipolar Radiofrequency Device.
abstract: BACKGROUND
  The dual-electrode bipolar-RFA (B-RFA) is increasingly used to ablate large liver tumours (3-7 cm). However, the challenging aspect of B-RFA is the placement of the two electrodes around the tumour. Realignment often requires the electrodes to be extracted and reinserted.
  
  
  OBJECTIVE
  The aim of this study is to examine "Edgeboost", a novel technique to increase the lateral ablation dimension without requiring any realignment of the electrodes.
  
  
  METHODS
  An egg-white model and an ex vivo calf liver model were used compare the standard bipolar mode ablation to Edgeboost-1 (reaching full impedance in bipolar mode initially, then cycling in unipolar mode between left and right probes) and Edgeboost-2 (similar to Edgeboost-1 but not reaching full impedance initially in bipolar mode in order to minimize charring and, thus, to increase total ablation time).
  
  
  RESULTS
  A significantly larger outer lateral ablation dimension to the probe was achieved with Edgeboost-1 compared to the standard method in the liver model (1.14 cm, SD: 0.16 vs. 0.44 cm, SD: 0.24, p = 0.04). Edgeboost-2 achieved the largest outer lateral ablation dimension of 1.75 cm (SD: 0.35). A similar association was seen in the egg model. Edgeboost-2 almost doubled the mass ablated with standard bipolar alone (mass ratio: 1:1.94 in egg white and 1:1.84 in liver).
  
  
  CONCLUSIONS
  This study demonstrates that the novel "Edgeboost" technique can increase the outer lateral ablation dimension without requiring the two inserted electrodes to be reinserted. This would be beneficial for interventionists who use the dual B-RFA.
authors.affiliation: Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Level 3, Pitney Building, Kogarah, Sydney, NSW, 2217, Australia. ruth.huo@gmail.com.|St George Clinical School, University of New South Wales, Sydney, NSW, Australia. ruth.huo@gmail.com.
authors.forename: Ya Ruth
authors.initials: YR
authors.lastname: Huo
authors.affiliation: Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Level 3, Pitney Building, Kogarah, Sydney, NSW, 2217, Australia. panthera6444@yahoo.com.au.
authors.forename: Krishna
authors.initials: K
authors.lastname: Pillai
authors.affiliation: Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Level 3, Pitney Building, Kogarah, Sydney, NSW, 2217, Australia. s8603151@unsw.edu.au.
authors.forename: Javed
authors.initials: J
authors.lastname: Akhter
authors.affiliation: Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Level 3, Pitney Building, Kogarah, Sydney, NSW, 2217, Australia. david.morris@unsw.edu.au.|St George Clinical School, University of New South Wales, Sydney, NSW, Australia. david.morris@unsw.edu.au.
authors.forename: David L
authors.identifier: http://orcid.org/0000-0001-6282-7677
authors.initials: DL
authors.lastname: Morris
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods*; D002417:Cattle; D004531:Eggs; D004566:Electrodes; D004867:Equipment Design; D008099:Liver
keywords: Bipolar; Dual-probe; Edgeboost; InCircle; Novel technique; Radiofrequency ablation