title: The concept and evolution of involved site radiation therapy for lymphoma.
abstract: We describe the development of radiation therapy for lymphoma from extended field radiotherapy of the past to modern conformal treatment with involved site radiation therapy based on advanced imaging, three-dimensional treatment planning and advanced treatment delivery techniques. Today, radiation therapy is part of the multimodality treatment of lymphoma, and the irradiated tissue volume is much smaller than before, leading to highly significant reductions in the risks of long-term complications.
authors.affiliation: Department of Oncology and Hematology, Section 3994, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark. lena.specht@regionh.dk.
authors.forename: Lena
authors.identifier: http://orcid.org/0000-0002-6902-2190
authors.initials: L
authors.lastname: Specht
authors.affiliation: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Joachim
authors.initials: J
authors.lastname: Yahalom
mesh_terms: D006801:Humans; D021621:Imaging, Three-Dimensional; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D008223:Lymphoma / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D047368:Tumor Burden
keywords: Lymphoma; Radiation therapy