title: Collision cross section calibrants for negative ion mode traveling wave ion mobility-mass spectrometry.
abstract: Unlike traditional drift-tube ion mobility-mass spectrometry, traveling-wave ion mobility-mass spectrometry typically requires calibration in order to generate collision cross section (CCS) values. Although this has received a significant amount of attention for positive-ion mode analysis, little attention has been paid for CCS calibration in negative ion mode. Here, we provide drift-tube CCS values for [M - H](-) ions of two calibrant series, polyalanine and polymalic acid, and evaluate both types of calibrants in terms of the accuracy and precision of the traveling-wave ion mobility CCS values that they produce.
authors.affiliation: NSF/NASA Center for Chemical Evolution.
authors.forename: Jay G
authors.initials: JG
authors.lastname: Forsythe
authors.forename: Anton S
authors.initials: AS
authors.lastname: Petrov
authors.forename: Chelsea A
authors.initials: CA
authors.lastname: Walker
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Allen
authors.forename: Jarrod S
authors.initials: JS
authors.lastname: Pellissier
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Bush
authors.forename: Nicholas V
authors.initials: NV
authors.lastname: Hud
authors.forename: Facundo M
authors.initials: FM
authors.lastname: Fernández
mesh_terms: D002138:Calibration; D008293:Malates / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D008293:Malates; D010455:Peptides; D011108:Polymers; C121060:poly(malic acid); C019529:polyalanine