title: Tumour Necrosis Factor-α Gene Polymorphism Is Associated with Metastasis in Patients with Triple Negative Breast Cancer.
abstract: Tumour necrosis factor-α (TNF-α) is critical in the regulation of inflammation and tumour progression. TNF-α-308G > A is associated with constitutively elevated TNF-α expression. The purpose of this study was to assess the association between TNF-α-308G > A and breast cancer (BC) risk by subtype and the connection between genotypes and clinical features of BC. A total of 768 patients and 565 controls were enrolled in this study, and genotypes were detected using the TaqMan assay. No effect on susceptibility for any BC subtype was found for the TNF-α-308 polymorphism in our study or in the pooled meta-analysis. This polymorphism was shown to be associated with age at menarche in all BC and in progesterone receptor-negative BC. Interestingly, triple negative breast cancer (TNBC) patients with TNF-α-308A had an increased risk of distant tumour metastasis (OR = 3.80, 95% CI: 1.31-11.02, P = 0.009). Multi-regression analysis showed that TNF-α-308A was also a risk factor for distant tumour metastasis after adjustment for tumour size and lymph node metastasis status (OR = 6.26, 95% CI: 1.88-20.87, P = 0.003). These findings indicate that TNF-α might play a distinct role in the progression of TNBC, especially in distant tumour metastasis of TNBC.
authors.affiliation: Department of Medical Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China.
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Liu
authors.affiliation: Department of Radiology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Medical Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250117, China.
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Sun
authors.affiliation: Department of Medical Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China.
authors.forename: Chun-Xiao
authors.initials: CX
authors.lastname: Chang
authors.affiliation: Department of Medical Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China.
authors.forename: Zhe-Hai
authors.initials: ZH
authors.lastname: Wang
authors.affiliation: Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Zhai
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016208:Databases, Factual; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D064726:Triple Negative Breast Neoplasms / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha