title: Polydopamine-Coated Magnetic Composite Particles with an Enhanced Photothermal Effect.
abstract: Recently, photothermal therapy (PTT) that utilizes photothermal conversion (PTC) agents to ablate cancer under near-infrared (NIR) irradiation has attracted a growing amount of attention because of its excellent therapeutic efficacy and improved target selectivity. Therefore, exploring novel PTC agents with an outstanding photothermal effect is a current research focus. Herein, we reported a polydopamine-coated magnetic composite particle with an enhanced PTC effect, which was synthesized simply through coating polydopamine (PDA) on the surface of magnetic Fe3O4 particles. Compared with magnetic Fe3O4 particles and PDA nanospheres, the core-shell nanomaterials exhibited an increased NIR absorption, and thus, an enhanced photothermal effect was obtained. We demonstrated the in vitro and in vivo effects of the photothermal therapy using our composite particles and their ability as a contrast agent in the T2-weighted magnetic resonance imaging. These results indicated that the multifunctional composite particles with enhanced photothermal effect are superior to magnetic Fe3O4 particles and PDA nanospheres alone.
authors.affiliation: †State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, No. 220 Handan Road, Shanghai 200433, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zheng
authors.affiliation: ‡School of Pharmacy and Key Laboratory of Smart Drug Delivery, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China.|§Pancreatic Disease Institute, Department of Pancreatic Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.affiliation: †State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, No. 220 Handan Road, Shanghai 200433, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: ‡School of Pharmacy and Key Laboratory of Smart Drug Delivery, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Jiang
authors.affiliation: §Pancreatic Disease Institute, Department of Pancreatic Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China.
authors.forename: Deliang
authors.initials: D
authors.lastname: Fu
authors.affiliation: ‡School of Pharmacy and Key Laboratory of Smart Drug Delivery, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Shun
authors.initials: S
authors.lastname: Shen
authors.affiliation: †State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, No. 220 Handan Road, Shanghai 200433, China.
authors.forename: Wuli
authors.initials: W
authors.lastname: Yang
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis; D003287:Contrast Media / Q000138:chemical synthesis; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry* / Q000627:therapeutic use; D008027:Light; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D008297:Male; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry* / Q000627:therapeutic use; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D007211:Indoles; D058185:Magnetite Nanoparticles; D017319:Photosensitizing Agents; D011108:Polymers; C568283:polydopamine; D052203:Ferrosoferric Oxide
keywords: Fe3O4; composite particles; photothermal therapy; polydopamine; tumor