title: Complete blood count parameters may have a role in diagnosis of gestational trophoblastic disease.
abstract: OBJECTIVE
  The goal of this study was to investigate whether gestational trophoblastic disease (GTD) and healthy pregnancy differ with respect to complete blood count parameters and these parameters can be used both to explain the pathophysiologic mechanisms and differentiate the two conditions from each other.
  
  
  METHODS
  The data obtained from 37 women with GTD and 61 healthy pregnancies (control group) regarding platelet (PLT), mean PLT volume (MPV) and PLT distribution width (PDW), and white blood cell (WBC) levels were evaluated. Patients with GTD were further subdivided into two groups composed of 20 partial mole (PM) and 17 complete mole (CM) cases.
  
  
  RESULTS
  PDW and WBC were lower in the GTD than the control. There were no differences for PLT and MPV. WBC was lower in PM and both WBC and PDW were lower in CM compared with control. ROC curve analysis revealed an area under curve (AUC) 75.5% for WBC and AUC 69.3% for PDW. A cut-off value was determined 8.19 for WBC with 81.0% sensitivity and 54.1% specificity. While, 15.85 were accepted for PDW, with 87.9% sensitivity and 44.4% specificity.
  
  
  CONCLUSIONS
  Lower WBC in GTD may suggest that molar pregnancy requires a lower inflammatory reaction facilitating trophoblastic invasion. Lower PDW as an indicator of platelet activation in CM may suggest that CM requires less PLT activation than healthy pregnancy that needs stronger trophoblast invasion for normal placental development. Decreased PDW levels especially < 15.85 and WBC levels < 8.19 may alert clinicians for risk of GTD.
authors.affiliation: Fatma Eskicioglu, Celal Bayar University, School of Medicine, Department of Obstetrics and Gynecology, 45050 Manisa, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Eskicioglu
authors.affiliation: Burcu Artunc Ulkumen, Celal Bayar University, School of Medicine, Department of Obstetrics and Gynecology, 45050 Manisa, Turkey.
authors.forename: Burcu Artunc
authors.initials: BA
authors.lastname: Ulkumen
authors.affiliation: Esat Calik, Celal Bayar University, School of Medicine, Department of Obstetrics and Gynecology, 45050 Manisa, Turkey.
authors.forename: Esat
authors.initials: E
authors.lastname: Calik
keywords: Gestational trophoblastic disease; Leukocyte count; Platelet activation