title: Association between polymorphisms in IL27 gene and renal cell carcinoma.
abstract: BACKGROUND
  Interleukin-27 is a new member of the IL-12 family which plays an important role in human carcinogenesis.
  
  
  OBJECTIVE
  To investigate whether polymorphisms in IL27 contribute to renal cell carcinoma (RCC) risk.
  
  
  METHODS
  These two polymorphisms were genotyped in 329 RCC patients and 386 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  Significantly increased RCC risk was associated the G allele of both rs153109 and rs17855750 (rs153109: p = 0.006, OR = 1.364, 95%CI = 1.095-1.700; rs17855750: p = 0.001, OR = 1.768, 95%CI = 1.245-2.511).
  
  
  CONCLUSIONS
  The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.
authors.affiliation: a Department of Forensic Biology , West China School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , Sichuan , P.R. China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Pu
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Wang
authors.forename: Yaping
authors.initials: Y
authors.lastname: Song
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human
keywords: Cytokine; IL27; polymorphisms; genetic susceptibility; renal cell carcinoma