title: Poly(acrylic acid) Bridged Gadolinium Metal-Organic Framework-Gold Nanoparticle Composites as Contrast Agents for Computed Tomography and Magnetic Resonance Bimodal Imaging.
abstract: Imaging contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT) have received significant attention in the development of techniques for early stage cancer diagnosis. Gadolinium (Gd)(III), which has seven unpaired electrons and a large magnetic moment, can dramatically influence the water proton relaxation and hence exhibits excellent MRI contrast. On the other hand, gold (Au), which has a high atomic number and high X-ray attenuation coefficient, is an ideal contrast agent candidate for X-ray-based CT imaging. Gd metal-organic framework (MOF) nanoparticles with tunable size, high Gd(III) loading and multivalency can potentially overcome the limitations of clinically utilized Gd chelate contrast agents. In this work, we report for the first time the integration of GdMOF nanoparticles with gold nanoparticles (AuNPs) for the preparation of a MRI/CT bimodal imaging agent. Highly stable hybrid GdMOF/AuNPs composites have been prepared by using poly(acrylic acid) as a bridge between the GdMOF nanoparticles and AuNPs. The hybrid nanocomposites were then evaluated in MRI and CT imaging. The results revealed high longitudinal relaxivity in MRI and excellent CT imaging performance. Therefore, these GdMOF/AuNPs hybrid nanocomposites potentially provide a new platform for the development of multimodal imaging probes.
authors.affiliation: †Department of Chemistry and Geochemistry, Colorado School of Mines, Golden, Colorado 80401, United States.
authors.forename: Chixia
authors.initials: C
authors.lastname: Tian
authors.affiliation: †Department of Chemistry and Geochemistry, Colorado School of Mines, Golden, Colorado 80401, United States.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhu
authors.affiliation: ‡Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.affiliation: †Department of Chemistry and Geochemistry, Colorado School of Mines, Golden, Colorado 80401, United States.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Boyes
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D014057:Tomography, X-Ray Computed
chemical_list: D000180:Acrylic Resins; D003287:Contrast Media; C006903:carbopol 940; D006046:Gold; D005682:Gadolinium
keywords: MRI/CT; gadolinium metal−organic framework nanoparticles; gold nanoparticles; multimodal imaging contrast agent