title: Lncing epigenetic control of transcription to cardiovascular development and disease.
abstract: Transcriptional and epigenetic regulation is critical for proper heart development, cardiac homeostasis, and pathogenesis. Long noncoding RNAs have emerged as key components of the transcriptional regulatory pathways that govern cardiac development as well as stress response, signaling, and remodeling in cardiac pathologies. Within the past few years, studies have identified many long noncoding RNAs in the context of cardiovascular biology and have begun to reveal the key functions of these transcripts. In this review, we discuss the growing roles of long noncoding RNAs in different aspects of cardiovascular development as well as pathological responses during injury or disease. In addition, we discuss diverse mechanisms by which long noncoding RNAs orchestrate cardiac transcriptional programs. Finally, we explore the exciting potential of this novel class of transcripts as biomarkers and novel therapeutic targets for cardiovascular diseases.
authors.affiliation: From the Department of Biology, Massachusetts Institute of Technology, Cambridge.
authors.forename: Gizem
authors.initials: G
authors.lastname: Rizki
authors.affiliation: From the Department of Biology, Massachusetts Institute of Technology, Cambridge. lboyer@mit.edu.
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Boyer
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena / Q000235:genetics*; D002319:Cardiovascular System / Q000254:growth & development*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D044127:Epigenesis, Genetic; D005318:Fetal Heart / Q000378:metabolism; D005544:Forecasting; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D006345:Heart Septal Defects, Ventricular / Q000235:genetics; D006657:Histones / Q000378:metabolism; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics; D032383:Myocytes, Cardiac / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000145:classification / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: cardiovascular disease; epigenomics; homeostasis; long noncoding RNA