title: Comparative Evaluation of Silicone Hydrogel Contact Lenses and Autologous Serum for Management of Sjögren Syndrome-Associated Dry Eye.
abstract: OBJECTIVE
  To comparatively evaluate the efficacy of a bandage contact lens (BCL) and autologous serum (AS) eye drops in the management of severe dry eye caused by Sjögren syndrome (SS).
  
  
  METHODS
  In this prospective randomized study, 40 patients with SS were enrolled. Patients were divided into 2 treatment groups: BCL and AS.
  
  
  RESULTS
  A total of 37 patients were included, 18 patients (35 eyes) in the AS group and 19 patients (36 eyes) in the BCL group. At the end of 6 weeks, the best-corrected visual acuity improved significantly in the BCL group (0.5 ± 0.3 vs. 0.3 ± 0.2, P = 0.003) but not in the AS group (0.4 ± 0.3 vs. 0.3 ± 0.3, P = 0.11). The best-corrected visual acuity remained stable up to 6 weeks after discontinuation of the BCL (0.5 ± 0.3 vs. 0.4 ± 0.2, P = 0.03). Although the Ocular Surface Disease Index scores decreased significantly after treatment in both groups, patients in the BCL group had lower Ocular Surface Disease Index scores than those in the AS group (53.4 vs. 41.8 at week 3, 47.1 vs. 31.0 at week 6, 52.7 vs. 32.0 at week 12; P = 0.014, <0.001, <0.004, respectively). The "faces" scores showed improved quality of life in both groups. Tear break-up time improved significantly in both groups except at 6 weeks after discontinuation of the AS. Patients in the BCL group had lower corneal staining scores than those of the AS group after 6 weeks of treatment and 6 weeks after discontinuation of treatment (P < 0.01). There was no significant change in Schirmer I test scores between or within groups.
  
  
  CONCLUSIONS
  Balafilcon A silicone hydrogel contact lenses as a BCL were effective in the management of SS-associated dry eye. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02147509.
authors.affiliation: *School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Zhejiang, China; and †Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Hong Kong.
authors.forename: Jinyang
authors.initials: J
authors.lastname: Li
authors.forename: Xiahua
authors.initials: X
authors.lastname: Zhang
authors.forename: Qinxiang
authors.initials: Q
authors.lastname: Zheng
authors.forename: Yirui
authors.initials: Y
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Huixiang
authors.initials: H
authors.lastname: Ma
authors.forename: Vishal
authors.initials: V
authors.lastname: Jhanji
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D000328:Adult; D001458:Bandages; D003263:Contact Lenses, Hydrophilic; D015352:Dry Eye Syndromes / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D020100:Hydrogels; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011446:Prospective Studies; D011788:Quality of Life; D044967:Serum; D012828:Silicones; D012859:Sjogren's Syndrome / Q000503:physiopathology / Q000628:therapy*; D011795:Surveys and Questionnaires; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020100:Hydrogels; D009883:Ophthalmic Solutions; D012828:Silicones; C523195:balafilcon A