title: The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles.
abstract: The controlled release of an anticancer agent from drug nanoparticles could be achieved by varying the linker length of dimeric compounds as prodrug. Notably, the cytotoxicity of the cancer cells was closely related to the release rate of drug compounds. This strategy will lead to the establishment of the novel delivery system using drug nanoparticles.
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan. hkasai@tagen.tohoku.ac.jp.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ikuta
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Koseki
authors.forename: Tsunenobu
authors.initials: T
authors.lastname: Onodera
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Oikawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kasai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003998:Dicarboxylic Acids / Q000737:chemistry; D019281:Dimerization; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011034:Podophyllotoxin / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003998:Dicarboxylic Acids; D004337:Drug Carriers; D011355:Prodrugs; D011034:Podophyllotoxin