title: Comparison of Atmospheric Pressure Ionization Gas Chromatography-Triple Quadrupole Mass Spectrometry to Traditional High-Resolution Mass Spectrometry for the Identification and Quantification of Halogenated Dioxins and Furans.
abstract: The goal of this study was to qualify gas chromatography coupled to atmospheric pressure ionization tandem mass spectrometry (APGC-MS/MS) as a reliable and valid technique for analysis of halogenated dioxins and furans that could be used in place of more traditional gas chromatography coupled to high-resolution mass spectrometry (GC-HRMS) analysis. A direct comparison of the two instrumental techniques was performed. APGC-MS/MS system sensitivity was demonstrated to be on the single femtogram level. The APGC-MS/MS analysis also demonstrated method detection limits (MDLs) in both sediment and fish that were 2-18 times lower than those determined for the GC-HRMS. Inlet conditions were established to prevent issues with sample carry-over, due largely to the enhanced sensitivity of this technique. Additionally, this work utilized direct injection for sample introduction through the split/splittless inlet. Finally, quantification of both sediment and fish certified reference materials were directly compared between the APGC-MS/MS and GC-HRMS. The APGC-MS/MS performed similarly to, if not better than, the GC-HRMS instrument in the analysis of these samples. This data is intended to substantiate APGC-MS/MS as a comparable technique to GC-HRMS for the analysis of dioxins and furans.
authors.affiliation: †Biochemistry, Microbiology, and Molecular Biology Department, The Pennsylvania State University, 107 Althouse Laboratory, University Park, Pennsylvania 16802, United States.
authors.forename: Kari L
authors.initials: KL
authors.lastname: Organtini
authors.affiliation: ‡Ontario Ministry of the Environment, 125 Resources Road, Toronto, Ontario, Canada, M9P 3 V6.
authors.forename: Liad
authors.initials: L
authors.lastname: Haimovici
authors.affiliation: ‡Ontario Ministry of the Environment, 125 Resources Road, Toronto, Ontario, Canada, M9P 3 V6.|§Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada, L8S 4M1.
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Jobst
authors.affiliation: ‡Ontario Ministry of the Environment, 125 Resources Road, Toronto, Ontario, Canada, M9P 3 V6.|∥Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada, M5S 3H6.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Reiner
authors.affiliation: ⊥Waters Corporation, 34 Maple Street, Milford, Massachusetts 01757, United States.
authors.forename: Adam
authors.initials: A
authors.lastname: Ladak
authors.affiliation: ⊥Waters Corporation, 34 Maple Street, Milford, Massachusetts 01757, United States.
authors.forename: Douglas
authors.initials: D
authors.lastname: Stevens
authors.affiliation: #Restek Corporation, 110 Benner Circle, Bellefonte, Pennsylvania 16823, United States.|○Forensic Science Program, The Pennsylvania State University, 107 Whitmore Laboratory, University Park, Pennsylvania 16802, United States.
authors.forename: Jack W
authors.initials: JW
authors.lastname: Cochran
authors.affiliation: †Biochemistry, Microbiology, and Molecular Biology Department, The Pennsylvania State University, 107 Althouse Laboratory, University Park, Pennsylvania 16802, United States.|○Forensic Science Program, The Pennsylvania State University, 107 Whitmore Laboratory, University Park, Pennsylvania 16802, United States.
authors.forename: Frank L
authors.initials: FL
authors.lastname: Dorman
mesh_terms: D001274:Atmospheric Pressure; D004147:Dioxins / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D005663:Furans / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D054879:Halogenation; D015386:Hazardous Substances / Q000032:analysis; D015394:Molecular Structure; D012989:Soil Pollutants / Q000032:analysis*; D053719:Tandem Mass Spectrometry
chemical_list: D004147:Dioxins; D005663:Furans; D015386:Hazardous Substances; D012989:Soil Pollutants