title: Plasma brain-derived neurotrophic factor levels in patients suffering from post-traumatic stress disorder.
abstract: A number of studies have been done to investigate the role of brain-derived neurotrophic factor (BDNF) in patients with post-traumatic stress disorder (PTSD). In this study we aimed to test the relationship between plasma BDNF levels and PTSD. We solicited 65 subjects having recently experienced road traffic accidents (RTA) conforming to screening criteria. They were given follow-up examinations after one month, three months, and six months. PTSD was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-R-TR, American Psychiatric Association, 2000) using the Mini International Neuropsychiatric Interview (MINI). All participants were divided into two groups: a group with PTSD and a group without PTSD. There were no significant differences in plasma BDNF levels between the two groups at either the 48h or six-month examination. Within the PTSD group, no significant differences were found in plasma BDNF levels between the two examinations. BDNF levels in those without PTSD showed a higher trend over time after trauma. Higher BDNF levels may be an important protective factor for the prevention of traumatized subjects from developing PTSD.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Su
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, PR China. Electronic address: xiaozeping88@163.com.
authors.forename: Zeping
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, PR China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors.forename: Yichao
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, PR China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China. Electronic address: wangzhen@smhc.org.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000063:Accidents, Traffic / Q000523:psychology; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013313:Stress Disorders, Post-Traumatic / Q000097:blood* / Q000523:psychology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: BDNF/ brain-derived neurotrophic factor; PTSD/post-traumatic stress disorder; Stress; Trauma