title: Roles of A20 in autoimmune diseases.
abstract: A20 (TNFAIP3), known to inhibit NF-κB function by deubiquitinating-specific NF-κB signaling molecules, has been found in many cell types of the immune system. Recent findings suggest that A20 is essential for the development and functional performance of dendritic cell, B cell, T cell and macrophage. A number of studies further demonstrate that these cells are crucial in the pathogenesis of autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, inflammatory bowel disease, ankylosing arthritis, Sjögren's syndrome and rheumatoid arthritis. In this article, we focus on the recent advances on the roles of A20 in autoimmune diseases and discuss the therapeutic significance of these new findings.
authors.affiliation: Suzhou High-tech Zone Center for Disease Prevention and Control, 35 Dengwei Road, Suzhou, 215011, Jiangsu, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: The Second People's Hospital of Wuhu, 259 Jiuhua Central Road, Wuhu, 241000, Anhui, People's Republic of China.
authors.forename: Ling-Long
authors.initials: LL
authors.lastname: Peng
authors.affiliation: Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China.
authors.forename: Jian-Shu
authors.initials: JS
authors.lastname: Wang
authors.affiliation: Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Liu
authors.affiliation: Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China.
authors.forename: Meng-Meng
authors.initials: MM
authors.lastname: Liu
authors.affiliation: Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Hu
authors.affiliation: Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Song
authors.affiliation: Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China. yhbing111@163.com.
authors.forename: Hai-Bing
authors.initials: HB
authors.lastname: Yang
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D015551:Autoimmunity; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016207:Cytokines; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3
keywords: A20 (TNFAIP3); Autoimmune diseases; Autoimmunity; Immune cells