title: Tuberculosis and Leprosy: Classical Granulomatous Diseases in the Twenty-First Century.
abstract: Leprosy and tuberculosis are chronic mycobacterial infections that elicit granulomatous inflammation. Both infections are curable, but granulomatous injury to cutaneous structures, including cutaneous nerves in leprosy, may cause permanent damage. Both diseases are major global concerns: tuberculosis for its high prevalence and mortality, and leprosy for its persistent global presence and high rate of neuropathic disability. Cutaneous manifestations of both leprosy and tuberculosis are frequently subtle and challenging in dermatologic practice and often require a careful travel and social history and a high index of suspicion.
authors.affiliation: National Hansen's Disease Programs, 1770 Physician Park Drive, Baton Rouge, LA 70816, USA. Electronic address: dscollard@hrsa.gov.
authors.forename: David M
authors.initials: DM
authors.lastname: Scollard
authors.affiliation: Center for Dermatology and Cosmetic Laser Surgery, 5026 Tennyson Parkway, Plano, TX 75024, USA; Department of Dermatology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9069, USA.
authors.forename: Mara M
authors.initials: MM
authors.lastname: Dacso
authors.affiliation: Department of Dermatology, Jose R. Reyes Memorial Medical Center, Rizal Avenue, Manila 1008, Philippines.
authors.forename: Ma Luisa
authors.initials: ML
authors.lastname: Abad-Venida
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use; D007918:Leprosy / Q000175:diagnosis / Q000188:drug therapy; D015440:Leprosy, Lepromatous / Q000175:diagnosis* / Q000188:drug therapy; D015441:Leprosy, Tuberculoid / Q000175:diagnosis* / Q000188:drug therapy; D008177:Lupus Vulgaris / Q000175:diagnosis* / Q000188:drug therapy; D012867:Skin / Q000473:pathology*; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy; D014391:Tuberculosis, Miliary / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D007917:Leprostatic Agents
keywords: Atypical mycobacteria; Cell-mediated immunity; Granuloma; Hansen disease; Leprosy; Leprosy reaction; Lupus vulgaris; Tuberculosis