title: Inverse association between yerba mate consumption and idiopathic Parkinson's disease. A case-control study.
abstract: Yerba mate tea is a very common beverage in some countries of South America. We conducted a case-control study on an individual basis using hospital records to investigate the association between Parkinson's disease (PD) and yerba mate intake. A case was defined as an age of ≥ 40 years with ≥ 1 year of PD. Each case was individually matched by two controls. Exposure was measured by yerba mate consumption, coffee, tea, and alcohol intake and smoking status. The sample consisted of 223 PD patients (mean age 68 years and mean disease duration 7.3 years) and 406 controls. There was an inverse association between yerba mate "bombilla" consumption and PD (OR 0.64, 95% CI: 0.54-0.76, p=0.00001). A multivariate analysis with a logistic regression adjusted by sex, alcohol intake and smoking provided the following results: yerba mate (OR 0.63, 95% CI: 0.53-0.76), tea (OR 0.60, 95% CI: 0.42-0.86), coffee (OR 0.51, 95% CI: 0.35-0.73). We found an inverse association between yerba mate consumption and PD. These results led us to hypothesize that yerba mate may have a potential protective role in the development of PD.
authors.affiliation: Instituto de Neurociencias Buenos Aires, INEBA, Buenos Aires, Argentina. Electronic address: emiliamgatto@gmail.com.
authors.forename: Emilia Mabel
authors.initials: EM
authors.lastname: Gatto
authors.affiliation: Fundación para la Investigación en Neuroepidemiología (FINEP), Junín, Provincia de Buenos Aires, Argentina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Melcon
authors.affiliation: Departamento Neurología, Sanatorio de la Trinidad Mitre, Buenos Aires, Argentina.
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Parisi
authors.affiliation: Hospital A. Zubizarreta, Laboratorio de Investigación de la Memoria, Buenos Aires, Argentina.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bartoloni
authors.affiliation: Departamento de Farmacología, Facultad de Medicina, UBA, Argentina.
authors.forename: Claudio D
authors.initials: CD
authors.lastname: Gonzalez
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D000704:Analysis of Variance; D001118:Argentina / Q000453:epidemiology; D016022:Case-Control Studies; D003069:Coffee / Q000009:adverse effects; D005260:Female; D006801:Humans; D030019:Ilex paraguariensis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D003069:Coffee
keywords: Parkinson's disease; Risk factors; Yerba mate