title: Clinical and epidemiological characteristics of acute respiratory virus infections in Vietnamese children.
abstract: Information about viral acute respiratory infections (ARIs) is essential for prevention, diagnosis and treatment, but it is limited in tropical developing countries. This study described the clinical and epidemiological characteristics of ARIs in children hospitalized in Vietnam. Nasopharyngeal samples were collected from children with ARIs at Ho Chi Minh City Children's Hospital 2 between April 2010 and May 2011 in order to detect respiratory viruses by polymerase chain reaction. Viruses were found in 64% of 1082 patients, with 12% being co-infections. The leading detected viruses were human rhinovirus (HRV; 30%), respiratory syncytial virus (RSV; 23·8%), and human bocavirus (HBoV; 7·2%). HRV was detected all year round, while RSV epidemics occurred mainly in the rainy season. Influenza A (FluA) was found in both seasons. The other viruses were predominant in the dry season. HRV was identified in children of all age groups. RSV, parainfluenza virus (PIV) 1, PIV3 and HBoV, and FluA were detected predominantly in children aged 24 months, respectively. Significant associations were found between PIV1 with croup (P < 0·005) and RSV with bronchiolitis (P < 0·005). HBoV and HRV were associated with hypoxia (P < 0·05) and RSV with retraction (P < 0·05). HRV, RSV, and HBoV were detected most frequently and they may increase the severity of ARIs in children.
authors.affiliation: Department of Developmental Medical Sciences,School of International Health,Graduate School of Medicine,The University of Tokyo,Tokyo,Japan.
authors.forename: D N
authors.initials: DN
authors.lastname: Tran
authors.affiliation: Division of Microbiology,Department of Pathology and Microbiology,Nihon University School of Medicine,Tokyo,Japan.
authors.forename: Q D
authors.initials: QD
authors.lastname: Trinh
authors.affiliation: Division of Microbiology,Department of Pathology and Microbiology,Nihon University School of Medicine,Tokyo,Japan.
authors.forename: N T K
authors.initials: NT
authors.lastname: Pham
authors.affiliation: Department of Pediatrics,University of Medicine and Pharmacy at Ho Chi Minh City,Ho Chi Minh City,Vietnam.
authors.forename: M P
authors.initials: MP
authors.lastname: Vu
authors.affiliation: Children's Hospital 2,Ho Chi Minh City,Vietnam.
authors.forename: M T
authors.initials: MT
authors.lastname: Ha
authors.affiliation: Department of Developmental Medical Sciences,School of International Health,Graduate School of Medicine,The University of Tokyo,Tokyo,Japan.
authors.forename: T Q N
authors.initials: TQ
authors.lastname: Nguyen
authors.affiliation: Department of Developmental Medical Sciences,School of International Health,Graduate School of Medicine,The University of Tokyo,Tokyo,Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okitsu
authors.affiliation: Division of Microbiology,Department of Pathology and Microbiology,Nihon University School of Medicine,Tokyo,Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hayakawa
authors.affiliation: Department of Developmental Medical Sciences,School of International Health,Graduate School of Medicine,The University of Tokyo,Tokyo,Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mizuguchi
authors.affiliation: Department of Developmental Medical Sciences,School of International Health,Graduate School of Medicine,The University of Tokyo,Tokyo,Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ushijima
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001988:Bronchiolitis / Q000821:virology; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000453:epidemiology / Q000821:virology; D003371:Cough / Q000821:virology; D003440:Croup / Q000821:virology; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006760:Hospitalization; D056661:Human bocavirus / Q000302:isolation & purification; D006801:Humans; D000860:Hypoxia / Q000821:virology; D007223:Infant; D009980:Influenza A virus / Q000302:isolation & purification; D007251:Influenza, Human / Q000150:complications / Q000453:epidemiology; D008297:Male; D009305:Nasopharynx / Q000821:virology; D010222:Parainfluenza Virus 1, Human / Q000302:isolation & purification; D010224:Parainfluenza Virus 3, Human / Q000302:isolation & purification; D010322:Parvoviridae Infections / Q000150:complications / Q000453:epidemiology; D010850:Picornaviridae Infections / Q000150:complications / Q000453:epidemiology; D018357:Respiratory Syncytial Virus Infections / Q000150:complications / Q000453:epidemiology; D018113:Respiratory Syncytial Virus, Human / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology*; D010253:Respirovirus Infections / Q000150:complications / Q000453:epidemiology; D012229:Rhinovirus / Q000302:isolation & purification; D012621:Seasons; D014744:Vietnam / Q000453:epidemiology
chemical_list: D004279:DNA, Viral
keywords: Acute respiratory infection; Vietnam; children; epidemiology