title: Granulomatous Drug Eruptions.
abstract: Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a granulomatous reaction pattern are rare, and defined by a predominance of histiocytes in the inflammatory infiltrate. This review summarizes current knowledge on the various types of granulomatous drug eruptions, focusing on the 4 major types: interstitial granulomatous drug reaction, drug-induced accelerated rheumatoid nodulosis, drug-induced granuloma annulare, and drug-induced sarcoidosis.
authors.affiliation: Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M1-737, Toronto, ON M4N 3M5, Canada; Department of Dermatology, Ha'emek Medical Center, Afula 18101, Israel.
authors.forename: Roni P
authors.initials: RP
authors.lastname: Dodiuk-Gad
authors.affiliation: Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M1-737, Toronto, ON M4N 3M5, Canada; Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room M1-737, Toronto, Ontario M4N 3M5, Canada. Electronic address: neil.shear@sunnybrook.ca.
authors.forename: Neil H
authors.initials: NH
authors.lastname: Shear
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects; D000998:Antiviral Agents / Q000009:adverse effects; D002121:Calcium Channel Blockers / Q000009:adverse effects; D003875:Drug Eruptions / Q000175:diagnosis*; D006099:Granuloma / Q000139:chemically induced / Q000175:diagnosis*; D016460:Granuloma Annulare / Q000139:chemically induced / Q000175:diagnosis*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects; D012218:Rheumatoid Nodule / Q000139:chemically induced / Q000175:diagnosis*; D012507:Sarcoidosis / Q000139:chemically induced / Q000175:diagnosis*
chemical_list: D018501:Antirheumatic Agents; D000998:Antiviral Agents; D002121:Calcium Channel Blockers; D016898:Interferon-alpha
keywords: Drug; Granuloma; Granulomatous drug eruptions; Noninfectious granuloma; Skin