title: Do pre-procedural laboratory parameters predict drug-eluting stent restenosis?
abstract: OBJECTIVE
  Drug-eluting stents (DES) have considerably reduced the rates of in-stent restenosis (ISR). Several studies reported pre-procedural C-reactive protein (CRP), neutrophil to lymphocyte (N/L) ratio, red cell distribution width (RDW), serum uric acid (UA), and mean platelet volume (MPV) as independent predictors of ISR using bare metal stents. This study investigates whether any laboratory parameter obtained before the coronary stenting procedure is associated with ISR using DES in stable coronary artery disease.
  
  
  METHODS
  Three hundred fifteen stents were retrospectively analysed in 285 patients who had undergone coronary stenting and a control coronary angiography within one year of stenting, between January 2012 and April 2014. Pre-procedural complete blood count, biochemistry, and CRP were recorded. Off-line quantitative coronary angiography analysis was performed.
  
  
  RESULTS
  Overall restenosis rate was 10.2%. When the stents were analysed with respect to the presence of ISR, the number of diabetics and smokers was higher in the ISR group. CRP levels were significantly higher in the ISR group, but there were no differences in N/L, monocytes, eosinophils, RDW, MPV, UA, and total bilirubin levels. In the univariate regression analysis, DM, CRP, stent length, stent diameter, pre-procedural diameter stenosis, pre-procedural minimal lumen diameter (MLD), post-procedural residual diameter stenosis, post-procedural reference vessel diameter, and post-procedural MLD were predictors of ISR. However, multivariate regression analysis identified only DM and post-procedural residual stenosis as independent predictors of ISR.
  
  
  CONCLUSIONS
  Pre-procedural blood parameters do not independently predict ISR in DES, which is mainly determined by the presence of diabetes and post-procedural residual stenosis.
authors.affiliation: Department of Cardiology, Ufuk University Faculty of Medicine, Ankara, Turkey. aslitanindi@gmail.com.
authors.forename: Aslı
authors.initials: A
authors.lastname: Tanındı
authors.affiliation: Department of Cardiology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Berkay
authors.initials: B
authors.lastname: Ekici
authors.affiliation: Department of Cardiology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hasan Fehmi
authors.initials: HF
authors.lastname: Töre
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D023903:Coronary Restenosis / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein