title: BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells.
abstract: Many members of the BTB-ZF family have been shown to play important roles in lymphocyte development and function. The role of zinc finger Znf131 (also known as Zbtb35) in T cell lineage was elucidated through the production of mice with floxed allele to disrupt at different stages of development. In this article, we present that Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled. In mature T cells, Znf131 is required for the activation of effector genes, as well as robust proliferation induced upon TCR signal. One of the cyclin-dependent kinase inhibitors, p21(Cip1) encoded by cdkn1a gene, is one of the targets of Znf131. The regulation of T cell proliferation by Znf131 is in part attributed to its suppression on the expression of p21(Cip1).
authors.affiliation: Laboratory of Self Defense Gene Regulation, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan; Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan;
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iguchi
authors.affiliation: Laboratory of Self Defense Gene Regulation, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Aoki
authors.affiliation: Young Chief Investigators Laboratory for Immune Regeneration, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan;
authors.forename: Tomokatsu
authors.initials: T
authors.lastname: Ikawa
authors.affiliation: Laboratory of Biochemistry, Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan;
authors.forename: Masato
authors.initials: M
authors.lastname: Taoka
authors.affiliation: Animal Research Division, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;
authors.forename: Choji
authors.initials: C
authors.lastname: Taya
authors.affiliation: Laboratory of Self Defense Gene Regulation, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshitani
authors.affiliation: Department of Otolaryngology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan;
authors.forename: Makiko
authors.initials: M
authors.lastname: Toma-Hirano
authors.affiliation: Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan;
authors.forename: Osamu
authors.initials: O
authors.lastname: Koiwai
authors.affiliation: Laboratory of Biochemistry, Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan;
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Isobe
authors.affiliation: Department of Immunology, Field of Regeneration Control, Institute of Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan; and.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawamoto
authors.affiliation: Genome Dynamics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Masai
authors.affiliation: Laboratory of Self Defense Gene Regulation, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan; miyatake-si@igakuken.or.jp.
authors.forename: Shoichiro
authors.identifier: http://orcid.org/0000-0001-8796-1653
authors.initials: S
authors.lastname: Miyatake
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D002460:Cell Line; D049109:Cell Proliferation; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000096:biosynthesis / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009687:Nuclear Proteins / Q000276:immunology; D011401:Promoter Regions, Genetic / Q000235:genetics; D050828:Protein Inhibitors of Activated STAT / Q000276:immunology; D020598:Proto-Oncogene Proteins c-myb / Q000235:genetics / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases
chemical_list: C493957:Cdkn1a protein, mouse; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D050828:Protein Inhibitors of Activated STAT; D020598:Proto-Oncogene Proteins c-myb; D016693:Receptors, Antigen, T-Cell, alpha-beta; D014157:Transcription Factors; C519600:ZNF131 protein, mouse; C485521:Miz1 protein, mouse; D044767:Ubiquitin-Protein Ligases