title: PAX5-KIAA1549L: a novel fusion gene in a case of pediatric B-cell precursor acute lymphoblastic leukemia.
abstract: BACKGROUND
  In B-cell precursor acute lymphoblastic leukemia (BCP-ALL) PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is frequently affected by genetic alterations. In 2-3 % of the cases PAX5 rearrangements result in the expression of oncogenic fusion genes. The encoded chimeric proteins consist of the N-terminal PAX5 DNA-binding paired domain, which is fused to the C-terminal domains of a remarkable heterogeneous group of partner proteins.
  
  
  RESULTS
  Employing fluorescence in situ hybridization and molecular methods PAX5-KIAA1549L was identified as novel fusion gene in a case of pediatric BCP-ALL.
  
  
  CONCLUSIONS
  Our report underlines the high diversity of PAX5 fusion partners in BCP-ALL and we describe the second involvement of KIAA1549L in a genetic rearrangement in acute leukemia.
authors.affiliation: CCRI, Children's Cancer Research Institute, St. Anna Kinderkrebsforschung e.V., Vienna, Austria.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Anderl
authors.affiliation: CCRI, Children's Cancer Research Institute, St. Anna Kinderkrebsforschung e.V., Vienna, Austria.
authors.forename: Margit
authors.initials: M
authors.lastname: König
authors.affiliation: Department of Pediatrics, St. Anna Children's Hospital, Vienna, Austria ; Medical University of Vienna, Vienna, Austria.
authors.forename: Andishe
authors.initials: A
authors.lastname: Attarbaschi
authors.affiliation: CCRI, Children's Cancer Research Institute, St. Anna Kinderkrebsforschung e.V., Vienna, Austria.
authors.forename: Sabine
authors.initials: S
authors.lastname: Strehl
keywords: B-cell precursor acute lymphoblastic leukemia; KIAA1549L; PAX5 fusion