title: [Evolution of the management of pediatric and adult medulloblastoma].
abstract: Medulloblastoma are cerebellar tumours belonging to the group of primitive neuroectodermal tumours (PNET) and are the most common malignant brain tumours of childhood. These tumours are rare and heterogeneous, requiring some multicentric prospective studies and multidisciplinary care. The classical therapeutic approaches are based on clinical, radiological and surgical data. They involve surgery, radiation therapy and chemotherapy. Some histological features were added to characterize risk. More recently, molecular knowledge has allowed to devise risk-adapted strategies and helped to define groups with good outcome and reduce long-term sequelae, improve the prognostic of high-risk medulloblastoma and develop new therapeutic tools.
authors.affiliation: Département de radiothérapie, centre de lutte contre le cancer Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Vigneron
authors.affiliation: Service d'oncologie pédiatrique, CHU Hautepierre, 1, avenue Molière, 67098 Strasbourg cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Entz-Werlé
authors.affiliation: Service d'oncologie pédiatrique, CHU Hautepierre, 1, avenue Molière, 67098 Strasbourg cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Lutz
authors.affiliation: Service d'oncologie pédiatrique, CHU Hautepierre, 1, avenue Molière, 67098 Strasbourg cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Spiegel
authors.affiliation: Service d'oncologie pédiatrique, CHU Hautepierre, 1, avenue Molière, 67098 Strasbourg cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Jannier
authors.affiliation: Département de radiothérapie, institut Curie, 26, rue d'Ulm, 75005 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Helfre
authors.affiliation: Département de radiothérapie, institut Curie, 26, rue d'Ulm, 75005 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Alapetite
authors.affiliation: Service de neurochirurgie, CHU Hautepierre, 1, avenue Molière, 67098 Strasbourg cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Coca
authors.affiliation: Service de neurochirurgie, CHU Hautepierre, 1, avenue Molière, 67098 Strasbourg cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Kehrli
authors.affiliation: Département de radiothérapie, centre de lutte contre le cancer Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; Laboratoire EA 3430, fédération de médecine translationnelle de Strasbourg (FMTS), université de Strasbourg, 4, rue Kirschleger, 67085 Strasbourg cedex, France. Electronic address: gnoel@strasbourg.unicancer.fr.
authors.forename: G
authors.initials: G
authors.lastname: Noël
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000145:classification / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002658:Developmental Disabilities / Q000209:etiology; D020022:Genetic Predisposition to Disease; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008527:Medulloblastoma / Q000145:classification / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D009155:Mutism / Q000209:etiology; D009364:Neoplasm Recurrence, Local; D011182:Postoperative Care; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; D051153:Wnt Proteins
keywords: Adult; Adulte; Child; Enfant; Management; Medulloblastoma; Médulloblastomes; Prise en charge