title: A bioactive cycloartane triterpene from Garcinia hombroniana.
abstract: The dichloromethane bark extract of Garcinia hombroniana yielded one new cycloartane triterpene; (22Z,24E)-3β-hydroxycycloart-14,22,24-trien-26-oic acid (1) together with five known compounds: garcihombronane G (2), garcihombronane J (3), 3β acetoxy-9α-hydroxy-17,14-friedolanostan-14,24-dien-26-oic acid (4), (22Z, 24E)-3β, 9α-dihydroxy-17,14-friedolanostan-14,22,24-trien-26-oic acid (5) and 3β, 23α-dihydroxy-17,14-friedolanostan-8,14,24-trien-26-oic acid (6). Their structures were established by the spectral techniques of NMR and ESI-MS. These compounds together with some previously isolated compounds; garcihombronane B (7), garcihombronane D (8) 2,3',4,5'-tetrahydroxy-6-methoxybenzophenone (9), volkensiflavone (10), 4''-O-methyll-volkensiflavone (11), volkensiflavone-7-O-glucopyranoside (12), volkensiflavone-7-O-rhamnopyranoside (13), Morelloflavone (14), 3''-O-methyl-morelloflavone (15) and morelloflavone-7-O-glucopyranoside (16) were evaluated for cholinesterase enzymes inhibitory activities using acetylcholinesterase and butyrylcholinesterase. In these activities, compounds 1-9 showed good dual inhibition on both the enzymes while compounds 10-16 did not reasonably contribute to both the cholinesterases inhibitory effects.
authors.affiliation: a School of Chemical Sciences , Universiti Sains Malaysia , 11800 Minden , Penang , Malaysia.
authors.forename: Nargis
authors.initials: N
authors.lastname: Jamila
authors.affiliation: b Department of Chemistry , Kohat University of Science and Technology , 26000 Kohat , Khyber Pakhtunkhwa , Pakistan.
authors.forename: Naeem
authors.initials: N
authors.lastname: Khan
authors.affiliation: c Department of Electrical Engineering , CECOS University , 25000 Peshawar , Khyber Pakhtunkhwa , Pakistan.
authors.forename: Imran
authors.initials: I
authors.lastname: Khan
authors.affiliation: d Department of Bio-informatics and Biotechnology , International Islamic University , H-10, Islamabad , Pakistan.
authors.forename: Amir Atlas
authors.initials: AA
authors.lastname: Khan
authors.affiliation: e Department of Medical Lab Technology , University of Haripur , 22060 Haripur , Khyber Pakhtunkhwa , Pakistan.
authors.forename: Sadiq Noor
authors.initials: SN
authors.lastname: Khan
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D044946:Biflavonoids / Q000737:chemistry / Q000494:pharmacology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D029760:Garcinia / Q000737:chemistry*; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: C000619092:(22Z,24E)-3beta-hydroxycycloart-14,22,24-trien-26-oic acid; D044946:Biflavonoids; D002800:Cholinesterase Inhibitors; D014315:Triterpenes; C000619093:garcihombronane G; C000619094:garcihombronane J; C105620:morelloflavone; C085352:cycloartane; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
keywords: (22Z, 24E)-3β-hydroxycycloart-14,22,24-trien-26-oic acid; Garcinia hombroniana; acetylcholinesterase; butyrylcholinesterase