title: Hepatoid adenocarcinoma of the stomach: A case report and literature review.
abstract: Hepatoid adenocarcinoma (HAC) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. The present case report describes a patient who was referred to the No. 461 Hospital of PLA (Changchun, China) due to nausea and occasional vomiting of acid/water. The patient was diagnosed with gastric signet-ring cell carcinoma and surgery was recommended. A total gastrectomy was performed on the operable lesion. Histopathological analysis revealed that the tumors exhibited two pathological changes: HAC and signet-ring cell carcinoma differentiation. Furthermore, the tumor cells were immunohistochemically positive for α-fetoprotein, cytokeratin low/high molecular weight, Cam5.2, cytokeratin 7, p53, epithelial membrane antigen and carcinoembryonic antigen. Previous studies and our experience have suggested that HAC is an aggressive type of adenocarcinoma; however, radical surgery and chemotherapy may positively impact clinical outcomes.
authors.affiliation: Department of Pathology, No. 461 Clinical Department of No. 208 Hospital of PLA, Changchun, Jilin 130062, P.R. China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Liu
authors.affiliation: Department of Pathology, China-Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China.
authors.forename: Gui-Qiu
authors.initials: GQ
authors.lastname: Chen
authors.affiliation: Department of Surgery, No. 461 Clinical Department of No. 208 Hospital of PLA, Changchun, Jilin 130062, P.R. China.
authors.forename: Shun-Li
authors.initials: SL
authors.lastname: Li
authors.affiliation: Norman Bethune College of Medicine, Jilin University, Changchun, Jilin 130033, P.R. China.
authors.forename: Tian-Shu
authors.initials: TS
authors.lastname: Zai
keywords: hepatoid adenocarcinoma; stomach