title: Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study.
abstract: BACKGROUND
  Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status.
  
  
  OBJECTIVE
  To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state.
  
  
  METHODS
  We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]).
  
  
  RESULTS
  32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432).
  
  
  CONCLUSIONS
  We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.
authors.affiliation: Department of Dermatology, Roskilde Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Roskilde, Denmark.
authors.forename: Iben Marie
authors.initials: IM
authors.lastname: Miller
authors.forename: Maria Egede
authors.initials: ME
authors.lastname: Johansen
authors.forename: Ulla B
authors.initials: UB
authors.lastname: Mogensen
authors.forename: Kian
authors.initials: K
authors.lastname: Zarchi
authors.forename: Christina
authors.initials: C
authors.lastname: Ellervik
authors.forename: Gregor B E
authors.initials: GB
authors.lastname: Jemec
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D017497:Hidradenitis Suppurativa / Q000097:blood* / Q000453:epidemiology; D006761:Hospitals; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000097:blood / Q000453:epidemiology; D019851:Thrombophilia / Q000097:blood* / Q000453:epidemiology; D055815:Young Adult