title: Highly Active Antiretroviral Therapy (HAART)-Related Hypertriglyceridemia Is Associated With Failure of Recovery of CD14lowCD16+ Monocyte Subsets in AIDS Patients.
abstract: As cellular reservoirs, CD16 monocyte subsets play important roles in the progression of HIV infection. Previous studies have shown that highly active antiretroviral therapy (HAART) reduced the percentages of CD14CD16 monocyte subsets, but did not recover the percentages of CD14CD16 subsets. Eighty-four chronic HIV-infected, HAART-naïve individuals and 55 HIV-negative subjects (31 without hyperlipidemia and 24 with hypertriglyceridemia) were enrolled. Plasma HIV-1 RNA levels, CD4 T-cell counts, triglycerides, total cholesterol, high-density lipoprotein, and low-density lipoprotein were followed up for 48 weeks during HAART treatment in the longitudinal study. We found that mild hypertriglyceridemia in HIV-negative subjects and HIV-infected patients, naïve to HAART, did not affect the percentage of monocyte subsets. However, a failure of CD14CD16 subset recovery was observed in patients with HAART-related hypertriglyceridemia at 48 weeks. Thus, HAART-related hypertriglyceridemia altered homeostasis of monocyte subsets to antiviral therapy, which might further affect immune reconstitution.
authors.affiliation: From the Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University (JH, HZ, YH, YL, CS, HZ); Beijing Key Laboratory of Emerging Infectious Diseases (JH, HZ, YH, YL, CS, HZ); Division of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University (HZ, NH); Institute of Basic Medical Theory, China Academy of Chinese Medical Sciences (YM); Division of 2nd In Vitro Diagnostic Reagents, National Institutes for Food and Drug Control (HZ); Department of Medical Laboratory, Beijing Tongren Hospital, Capital Medical University (XL); and Department of Geriatric Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China (MQ). These authors contributed equally to this study.
authors.forename: Junyan
authors.initials: J
authors.lastname: Han
authors.forename: Hongxin
authors.initials: H
authors.lastname: Zhao
authors.forename: Yaluan
authors.initials: Y
authors.lastname: Ma
authors.forename: Haiwei
authors.initials: H
authors.lastname: Zhou
authors.forename: Yu
authors.initials: Y
authors.lastname: Hao
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Li
authors.forename: Chuan
authors.initials: C
authors.lastname: Song
authors.forename: Ning
authors.initials: N
authors.lastname: Han
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Zeng
authors.forename: Mingzhao
authors.initials: M
authors.lastname: Qin
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000276:immunology*; D008137:Longitudinal Studies; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D019562:Viral Load