title: The innate immune response in human tuberculosis.
abstract: Mycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini-review, we discuss these host-pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome-wide association studies).
authors.affiliation: Mill Hill Laboratory, The Francis Crick Institute, London, UK.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Lerner
authors.affiliation: Mill Hill Laboratory, The Francis Crick Institute, London, UK.
authors.forename: Sophie
authors.initials: S
authors.lastname: Borel
authors.affiliation: Mill Hill Laboratory, The Francis Crick Institute, London, UK.
authors.forename: Maximiliano G
authors.initials: MG
authors.lastname: Gutierrez
mesh_terms: D055106:Genome-Wide Association Study; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology*