title: The Effects of Lithium Administration on Oxidant/Antioxidant Status in Rats: Biochemical and Histomorphological Evaluations.
abstract: Present study was planned to determine possible dose-dependent effects of lithium (Li) on oxidant-antioxidant status and histomorphological changes in liver and kidney tissues. For this purpose, twenty-four Wistar male rats were equally divided into three groups: the rats in group I served as controls, drinking tap water without lithium. Groups II and III received 0.1 and 0.2 % lithium carbonate (Li2CO3) through their drinking water, respectively, for 30 days. At the end of the experimental period, lithium concentrations, levels of malondialdehyde (MDA) and glutathione (GSH) and superoxide dismutase (SOD) activities were measured in considered tissues. Histomorphological study was also performed on liver and kidney tissues. Compared to controls, MDA was significantly higher but GSH level lower in groups II and III. SOD activity was higher in group III, but no difference was determined in group II in liver tissue. In kidney tissue, there was no difference determined in MDA and GSH levels between control and experimental groups but SOD activity in groups II and III was significantly higher. In histologic sections of both experimental liver and kidney tissues, specific degenerations were observed. The results of the present study show that treatment with lithium carbonate may result in liver and kidney tissue abnormalities and oxidative damage.
authors.affiliation: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Selmin
authors.initials: S
authors.lastname: Toplan
authors.affiliation: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. hsf@istanbul.edu.tr.
authors.forename: Semra
authors.initials: S
authors.lastname: Ozdemir
authors.affiliation: Department of Histology and Embryology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Tanriverdi
authors.affiliation: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: M Can
authors.initials: MC
authors.lastname: Akyolcu
authors.affiliation: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Dervis
authors.initials: D
authors.lastname: Ozcelik
authors.affiliation: Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Nuran
authors.initials: N
authors.lastname: Darıyerli
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects*; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D008297:Male; D017208:Rats, Wistar
chemical_list: D000928:Antidepressive Agents; D016651:Lithium Carbonate
keywords: Antioxidants; Kidney; Lithium; Liver fibrosis; Oxidative stress