title: [Gout and and calcium pyrophosphate crystal arthropathies: pathophysiology].
abstract: Microcrystalline arthropathies are consecutive to microcrystals formation and deposition within the joint. The formation of monosodium urate crystals depends on many physico-chemical factors: the concentration of uric acid, the temperature and pH. Beyond 60 mg/L (360 µmol/L), uric acid crystallizes in tissues. Chronic hyperuricemia is a necessary condition for the occurrence of gouty arthropathy. The mechanisms of hyperuricemia and inflammatory access and their therapeutic implications are described. Chondrocalcinosis is a radiographic entity characterized by deposits of calcium pyrophosphate crystals (CPP) within the fibrocartilage or hyalin cartilage. CPP arthropathies symptomatology is polymorphic and likely resemble in primary osteoarthritis, pseudo-gout acute attacks, or chronic mono-, oligo- or polyarthritis. Its pathophysiology remains uncompletely understood, although there is growing knowledge on the place of some actors involved in the pathogenesis of chondrocalcinosis, described in the article.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Coiffier
authors.forename: Jean-David
authors.initials: JD
authors.lastname: Albert
mesh_terms: D000208:Acute Disease; D002131:Calcium Pyrophosphate / Q000378:metabolism; D002805:Chondrocalcinosis / Q000175:diagnosis / Q000209:etiology*; D006073:Gout / Q000209:etiology*; D006801:Humans; D014527:Uric Acid / Q000097:blood / Q000378:metabolism
chemical_list: D014527:Uric Acid; D002131:Calcium Pyrophosphate