title: Catalytic meta-selective C-H functionalization to construct quaternary carbon centres.
abstract: A catalytic meta-selective C-H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C-H functionalization proceeds through a radical process directed via a remote σ-activation.
authors.affiliation: Centre for Sustainable Chemical Technologies, University of Bath, Bath, BA2 7AY, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Paterson
authors.forename: Sahra
authors.initials: S
authors.lastname: St John-Campbell
authors.forename: Mary F
authors.initials: MF
authors.lastname: Mahon
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Press
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Frost
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D007536:Isomerism; D008958:Models, Molecular; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry*
chemical_list: D011725:Pyridines; C058324:2-phenylpyridine; D002244:Carbon; D006859:Hydrogen