title: Assessment of Serum Copper State after Gastrectomy with Roux-en-Y Reconstruction for Gastric Cancer.
abstract: BACKGROUND
  Some recent reports have noted that copper deficiency can occur in obese patients who have undergone bariatric surgery, such as Roux-en-Y (RY) gastric bypass or biliopancreatic diversion, or in patients who receive enteral nutrition through a jejunostomy. No reports appear to have assessed the serum copper state of patients following gastrectomy with RY reconstruction for gastric cancer.
  
  
  METHODS
  A cross-sectional study was conducted from June 2013 to December 2014. Serum copper levels (SCLs) in 242 out-clinic patients who underwent curative gastrectomy were obtained. Patients were classified into an RY group (n = 208) and a non-RY group (n = 34).
  
  
  RESULTS
  Hypocupremia was identified in 3 patients in the RY group (1.4%), and 2 patients in the non-RY group (5.9%; p = 0.146), but none experienced any symptoms caused by hypocupremia. No significant difference in the mean SCL was seen between the RY group (105.8 ± 21.2 µg/dl) and non-RY group (107.9 ± 22.7 µg/dl; p = 0.499). In the RY group, the mean SCL was significantly lower in younger patients, patients with follow-up period <3 years, and male patients.
  
  
  CONCLUSIONS
  Some patients developed hypocupremia after gastrectomy with RY reconstruction, but the number is acceptably low, and physical symptoms were unusual.
authors.affiliation: Department of Gastric Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kojima
authors.forename: Mikito
authors.initials: M
authors.lastname: Inokuchi
authors.forename: Keiji
authors.initials: K
authors.lastname: Kato
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sugita
authors.forename: Sho
authors.initials: S
authors.lastname: Otsuki
authors.forename: Kyoko
authors.initials: K
authors.lastname: Higuchi
authors.forename: Kenta
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
mesh_terms: D000328:Adult; D000368:Aged; D000713:Anastomosis, Roux-en-Y; D015415:Biomarkers / Q000097:blood; D003300:Copper / Q000097:blood / Q000172:deficiency*; D003430:Cross-Sectional Studies; D003677:Deficiency Diseases / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D013270:Stomach / Q000601:surgery*; D013274:Stomach Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D003300:Copper