title: UsingC. elegansfor aging research.
abstract: Over a century ago, the zoologist Emile Maupas first identified the nematode,Rhabditis elegans,in the soil in Algiers. Subsequent work and phylogenic studies renamed the speciesCaenorhabditis elegansor more commonly referred to asC. elegans; (Caenomeaning recent;rhabditismeaning rod;elegansmeaning nice). However, it was not until 1963, when Sydney Brenner, already successful from his work on DNA, RNA, and the genetic code, suggested the future of biological research lay in model organisms. Brenner believed that biological research required a model system that could grow in vast quantities in the lab, were cheap to maintain and had a simple body plan, and he chose the nematodeC. elegansto fulfill such a role. Since that time,C. eleganshas emerged as one of the premiere model systems for aging research. This paper reviews some initial identification of mutants with altered lifespan with a focus on genetics and then discusses advantages and disadvantages for usingC. elegansas a model system to understand human aging. This review focuses on molecular genetics aspects of this model organism.
authors.affiliation: Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School , Worcester , MA 01605 , USA.
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Tissenbaum
keywords: C. elegans; aging; dauer; insulin/IGF-1; longevity