title: Assessement of the pharmacokinetics, tissue distribution and excretion studies of a novel antiplatelet agent S007-867, following administration to rats.
abstract: S007-867 is a promising novel antiplatelet agent with better efficacy and lesser bleeding risk than existing agents. The present study investigated the absorption, tissue distribution, and excretion of S007-867 in rat model for further advancement of the molecule. A simple and robust ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) bioanalytical method was used to determine S007-867 in various matrices. Following oral administration, the compound was quickly dispersed in the various tissues and peak concentration levels were achieved within 0.5-1 h. Overall, exposure of drug, i.e., AUC in different tissues was found in the order of small intestine > liver > heart > spleen > lungs > kidney > brain. The total recoveries of the S007-867 within 96 h were 3.36% in urine and faeces. This might be due to a first-pass effect by the liver and intestine as most of the drug was eliminated in metabolite form. These findings provide a crucial information about further development of S007-867 as antithrombotic agent. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Pharmacokinetics & Metabolism Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.|Medicinal & Process Chemistry Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.
authors.forename: Hardik
authors.initials: H
authors.lastname: Chandasana
authors.affiliation: Pharmacokinetics & Metabolism Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.|Medicinal & Process Chemistry Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.
authors.forename: Yashpal S
authors.initials: YS
authors.lastname: Chhonker
authors.affiliation: Pharmacokinetics & Metabolism Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.|Medicinal & Process Chemistry Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.
authors.forename: Tulsankar Sachin
authors.initials: TS
authors.lastname: Laxman
authors.affiliation: Pharmacokinetics & Metabolism Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.
authors.forename: Yarra Durga
authors.initials: YD
authors.lastname: Prasad
authors.affiliation: Medicinal & Process Chemistry Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: K S
authors.affiliation: Medicinal & Process Chemistry Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Dikshit
authors.affiliation: Pharmacokinetics & Metabolism Div., CSIR-Central Drug Research Institute, Lucknow, 226031, India.|Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, Rafi Marg, New Delhi, 110 001, India.|Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, 229010, India.
authors.forename: Rabi S
authors.initials: RS
authors.lastname: Bhatta
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000191:economics / Q000379:methods*; D005243:Feces / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D053719:Tandem Mass Spectrometry / Q000191:economics / Q000379:methods*; D014018:Tissue Distribution
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: absorption; excretion; metabolism; pharmacokinetics; rat; tissue distribution