title: Evaluation of nasal mucociliary activity in patients with chronic renal failure.
abstract: The ability of respiratory mucosal surfaces to eliminate foreign particles and pathogens and to keep mucosal surfaces moist and fresh depends on mucociliary activity. Chronic renal failure (CRF) is an irreversible medical condition that may result in important extrarenal systemic consequences, such as cardiovascular, metabolic, and respiratory system abnormalities. Although there are studies describing nasal manifestations of CRF, data are lacking concerning the effects of the condition on nasal mucosa. The goal of the current study was to evaluate nasal mucociliary clearance (NMC) time in patients with CRF. This prospective cohort study conducted in a tertiary referral center included 32 non-diabetic end-stage CRF patients and 30 control individuals. The control group consisted of voluntary participants who had been referred to our clinic for symptoms other than rhinological diseases. The mean NMC times in CRF patients and control individuals were 12.51 ± 3.74 min (range 7-22 min) and 8.97 ± 1.83 min (range 6-13 min), respectively. The mean NMC time in patients with CRF was significantly longer than that in control individuals (p < 0.001). Clinicians must keep in mind that NMC time in CRF patients is prolonged and must follow-up these patients more closely for sinonasal and middle ear infections.
authors.affiliation: Department of Otorhinolaryngology, Medicine Faculty of Dumlupınar University, Kutahya, Turkey. ckucur@mynet.com.
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kucur
authors.affiliation: Department of Otorhinolaryngology, Medicine Faculty of Dumlupınar University, Kutahya, Turkey.
authors.forename: Isa
authors.initials: I
authors.lastname: Ozbay
authors.affiliation: Department of Nephrology, Dumlupınar University, Kutahya, Turkey.
authors.forename: Erim
authors.initials: E
authors.lastname: Gulcan
authors.affiliation: Department of Otorhinolaryngology, Evliya Celebi Training and Research Hospital, Kutahya, Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Kulekci
authors.affiliation: Department of Otorhinolaryngology, Medicine Faculty of Dumlupınar University, Kutahya, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aksoy
authors.affiliation: Department of Otorhinolaryngology, Medicine Faculty of Dumlupınar University, Kutahya, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Oghan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology*; D009297:Nasal Mucosa / Q000503:physiopathology*; D011446:Prospective Studies; D013997:Time Factors
keywords: Chronic renal failure; Nasal mucociliary activity; Nasal mucociliary clearance time; Saccharine transit test