title: Prevalence and risk factors of deep vein thrombosis in patients after spine surgery: a retrospective case-cohort study.
abstract: Deep vein thrombosis (DVT) is common seen in patients undergoing spine surgery. However, its prevalence and associated risk factors have not been well understood yet. This retrospective case-cohort study was designed to investigate risk factors for postoperative DVT using retrospectively collected data from department of spine surgery between 07/2013 and 07/2014. Univariate analysis and binary logistic regression analysis were used to determine risk factors for DVT. A total of 861 patients were admitted into DVT-associated analyses, including 410 males and 451 females, aged from 15 to 87 years old (median 54, IQR 18). Of them, 147 cases (17%) sustained postoperative DVT. DVT incidence was 15.9% in patients undergoing lumbar interbody fusion, 13.5% in patients treated by low-molecular-weight heparin (LMWH), while only 8.1% in patients without LMWH. However, it revealed no significant difference between LMWH group and non-LMWH group (χ(2) = 1.933, p = 0.164). Logistic regression equation was logit P = -4.09 + 0.05*X1 - 0.55*X2 + 0.41*X3 + 1.41*X7, (X1 = age; X2 = regions; X3 = hypertension; X7 = D-dimer). In this study, LMWH prophylaxis after spine surgery proved ineffective. Advanced age, D-dimer and hypertension have proved to be the risk factors for postoperative DVT in patients undergoing spine surgery.
authors.affiliation: Department of Spinal Surgery, The Third Hospital of Hebei Medical University, 139Ziqiang Road, Shijiazhuang 050051, PR China.
authors.forename: Si-Dong
authors.initials: SD
authors.lastname: Yang
authors.affiliation: Department of Spinal Surgery, The Third Hospital of Hebei Medical University, 139Ziqiang Road, Shijiazhuang 050051, PR China.
authors.forename: Huan
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Spinal Surgery, The Third Hospital of Hebei Medical University, 139Ziqiang Road, Shijiazhuang 050051, PR China.
authors.forename: Ya-Peng
authors.initials: YP
authors.lastname: Sun
authors.affiliation: Department of Spinal Surgery, The Third Hospital of Hebei Medical University, 139Ziqiang Road, Shijiazhuang 050051, PR China.
authors.forename: Da-Long
authors.initials: DL
authors.lastname: Yang
authors.affiliation: Department of Spinal Surgery, The Third Hospital of Hebei Medical University, 139Ziqiang Road, Shijiazhuang 050051, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Orthopaedic Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, PR China.
authors.forename: Shi-Qing
authors.initials: SQ
authors.lastname: Feng
authors.affiliation: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3East Qingchun Road, Hangzhou 310016, PR China.
authors.forename: Feng-Dong
authors.initials: FD
authors.lastname: Zhao
authors.affiliation: 1] Department of Spinal Surgery, The Third Hospital of Hebei Medical University, 139Ziqiang Road, Shijiazhuang 050051, PR China [2] Hebei Provincial Key Laboratory of Orthopaedic Biomechanics, 139Ziqiang Road, Shijiazhuang 050051, PR China.
authors.forename: Wen-Yuan
authors.initials: WY
authors.lastname: Ding
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013123:Spinal Fusion / Q000009:adverse effects*; D020246:Venous Thrombosis / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult