title: Complex Genetic Disorders: Evaluating When Genetic Research Findings Are Applicable for Genetic Counseling Practice.
abstract: Traditional genetic counseling processes and principles will be extended to a new realm-complex disorders. Although it may seem like a daunting task, understanding the methodologies used to study complex genetic disorders will enable genetic counselors to critically analyze research studies involving complex disorders. In this article, we explain newly evolving methodologies for genetic research, including case-control studies and transmission disequilibrium testing (TDT). Additionally, a framework is provided for evaluating original research findings and replication studies.
authors.affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, chantell@chg.mc.duke.edu.
authors.forename: C M
authors.initials: CM
authors.lastname: Wolpert
authors.forename: E C
authors.initials: EC
authors.lastname: Melvin
authors.forename: M C
authors.initials: MC
authors.lastname: Speer