title: Effects of Ringer's sodium pyruvate solution on serum tumor necrosis factor-α and interleukin-6 upon septic shock.
abstract: OBJECTIVE
  To study the effects of Ringer's sodium pyruvate solution on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) upon septic shock.
  
  
  METHODS
  Ninety emergency patients with septic shock were divided into a treatment group and a control group by random draw. The control group was resuscitated with 50 ml of compound sodium chloride (Ringer's solution), and the treatment group was given 50 ml of Ringer's sodium pyruvate solution. Both groups were basically treated.
  
  
  RESULTS
  All patients were successfully resuscitated. After treatment, extravascular lung water index, intrathoracic blood volume index, systemic vascular resistance index and cardiac index of the two groups were significantly improved compared with those before treatment (P<0.05). However, there were no significant inter-group differences at different time points (P>0.05). Blood lactic acid level, central venous oxygen saturation index and urine output were also improved after treatment, with significant inter-group differences (P<0.05). Serum TNF-α and IL-6 levels of both groups significantly decreased after treatment (P<0.05), and the levels of the treatment group were significantly lower than those of the control group (P<0.05). During 28 days of follow-up, the mortality rate of the treatment group (4.4%) was significantly lower than that of the control group (20.0%) (P<0.05).
  
  
  CONCLUSIONS
  Patients with septic shock are complicated with disordered expressions of inflammatory factors. During resuscitation, Ringer's sodium pyruvate solution can effectively promote blood circulation, mitigate inflammation and maintain acid-base equilibrium, thus decreasing the prognostic mortality rate.
authors.affiliation: Wei Dong, Department of Critical Care Medicine, Second District, Shandong Jining No. 1 People's Hospital, Jining 272011, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.affiliation: Guannan Zhang Shandong Jining No. 1 People's Hospital, Jining 272011, China.
authors.forename: Guannan
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Feng Qu, Chief Physician, Department of Critical Care Medicine, Second District, Shandong Jining No. 1 People's Hospital, Jining 272011, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Qu
keywords: Ringer’s sodium pyruvate solution; Septic shock; Tumor necrosis factor-α; interleukin-6