title: Emerging Regenerative Approaches for Periodontal Reconstruction: Practical Applications From the AAP Regeneration Workshop.
abstract: Focused Clinical Question: Can emerging technologies for periodontal regeneration become clinical reality? Summary: Emerging technologies are presenting options to hopefully improve the outcomes of regeneration in challenging clinical scenarios. Cellular allografts represent a current technology in which cells and scaffolds are being delivered directly to the periodontal lesion. Recombinant human fibroblast growth factor 2 and teriparatide (parathyroid 1-34) have each been tested in controlled prospective human randomized clinical trials, and both have been shown to have potential for periodontal regeneration. These examples, as well as other emerging technologies, show promise for continued advancement in the field of periodontal regenerative therapy. Conclusions: At present, there are indications that emerging technologies can be used successfully for periodontal regeneration. Case reports and clinical trials are being conducted with a variety of emerging technologies. However, many are yet to be approved by a regulatory agency, or there is a lack of evidence-based literature to validate their expanded use.
authors.affiliation: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.
authors.forename: Hector F
authors.initials: HF
authors.lastname: Rios
authors.affiliation: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.
authors.forename: Jill D
authors.initials: JD
authors.lastname: Bashutski
authors.affiliation: Department of Periodontology, Oregon Health and Science University, Portland, OR.|Private practice, Tigard, OR.
authors.forename: Bradley S
authors.initials: BS
authors.lastname: McAllister
authors.affiliation: Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Murakami
authors.affiliation: Department of Periodontics, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO.
authors.forename: Charles M
authors.initials: CM
authors.lastname: Cobb
authors.affiliation: Department of Periodontics, University of Texas Health Science Center at San Antonio Dental School, San Antonio, TX.|Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio,TX.
authors.forename: Yong-Hee
authors.initials: YH
authors.lastname: Patricia Chun
authors.affiliation: Department of Periodontics, Virginia Commonwealth University School of Dentistry, Richmond, VA.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Private practice, Park Ridge and Oakbrook Terrace, IL.|Department of Oral and Maxillofacial Surgery, School of Dentistry, Louisiana State University, New Orleans, LA.|Department of Graduate Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL.
authors.forename: George A
authors.initials: GA
authors.lastname: Mandelaris
authors.affiliation: Department of Periodontics, University of Texas Health Science Center at San Antonio Dental School, San Antonio, TX.
authors.forename: David L
authors.initials: DL
authors.lastname: Cochran
keywords: Guided tissue regeneration; investigative techniques; periodontal disease; tissue engineering; wound healing