title: Multivalent thioglycopeptoids via photoclick chemistry: potent affinities towards LecA and BC2L-A lectins.
abstract: Solution-phase synthesis of linear and cyclic β- and α,β-peptoids was coupled to photo-induced thiol-ene coupling reaction to readily access multivalent thioglycoclusters. A tetrameric cyclic β-peptoid scaffold displaying 1-thio-β-d-galactose or 1-thio-α-d-mannose has revealed by ITC experiments efficient binding potency for bacterial lectins LecA and BC2L-A, respectively.
authors.affiliation: Université Clermont Auvergne, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, F-63000 Clermont-Ferrand, France.
authors.forename: C
authors.initials: C
authors.lastname: Caumes
authors.forename: E
authors.initials: E
authors.lastname: Gillon
authors.forename: B
authors.initials: B
authors.lastname: Legeret
authors.forename: C
authors.initials: C
authors.lastname: Taillefumier
authors.forename: A
authors.initials: A
authors.lastname: Imberty
authors.forename: S
authors.initials: S
authors.lastname: Faure
mesh_terms: D057508:Burkholderia cenocepacia / Q000737:chemistry*; D057930:Click Chemistry; D037102:Lectins / Q000737:chemistry*; D015394:Molecular Structure; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry; D055668:Photochemical Processes; D011550:Pseudomonas aeruginosa / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D037102:Lectins; D034444:Peptoids; D013438:Sulfhydryl Compounds