title: Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF- κ B Signaling.
abstract: The present study was conducted to examine whether heat-processed Scutellariae Radix has an ameliorative effect on lipopolysaccharide- (LPS-) induced acute lung injury in mice. The effects of Scutellariae Radix heat-processed at 160°C (HSR) were compared with those of nonheat-processed Scutellariae Radix (NSR). The LPS-treated group displayed a markedly decreased body weight and significantly increased lung weight; however, the administration of NSR or HSR improved both the body and lung weights. The increased oxidative stress and inflammatory biomarker levels in the serum and lung were reduced significantly with HSR. The reduced superoxide dismutase and catalase increased significantly by both NSR and HSR. Also, the dysregulated oxidative stress and inflammation were significantly ameliorated by NSR and HSR. The expression of inflammatory mediators and cytokines by nuclear factor-kappa B activation was modulated through inhibition of a nuclear factor kappa Bα degradation. Also, lung histological change was markedly suppressed by HSR rather than NSR. Overall, the ameliorative effects of HSR were superior to those when being nonheat-processed. The representative flavonoid contents of Scutellariae Radix that include baicalin, baicalein, and wogonin were greater by heat process. These data reveal heat-processed Scutellariae Radix may be a critical factor involved in the improvement of lung disorders caused by LPS.
authors.affiliation: College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Yu Ock
authors.initials: YO
authors.lastname: Shin
authors.affiliation: College of Korean Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
authors.forename: Chan Hum
authors.initials: CH
authors.lastname: Park
authors.affiliation: Jeollanamdo Development Institute for Korean Traditional Medicine, Jeollanamdo 529-851, Republic of Korea.
authors.forename: Gyeong-Hwan
authors.initials: GH
authors.lastname: Lee
authors.affiliation: College of Korean Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea ; Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609-735, Republic of Korea ; Graduate School of Science and Engineering for Research, University of Toyama, Toyama 930-8555, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa
authors.affiliation: College of Korean Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Roh
authors.affiliation: College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Man Hee
authors.initials: MH
authors.lastname: Rhee