title: Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile.
abstract: Clostridium difficile is the major etiological agent of pseudomembranous colitis and is found in up to 20% of adult inpatients. The recommended treatment is antibiotic therapy with metronidazole and/or vancomycin. However, the recurrence rate may reach up to 25% and it increases in each episode. The newest alternative to treat diarrhea due to recurrent Clostridium difficile is fecal microbiota transplantation. The procedure was performed in 12 patients, with a 6-month follow-up on 10 of them. Of the ten cases, bacterial recurrence was diagnosed in only one patient, after a course of antibiotic to treat urinary tract infection, without presenting with diarrhea. The particularity of our study, besides being an unprecedented event in South America, is the way to perform the infusion of fecal microbiota by enteroscopy.
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Arnaldo José
authors.initials: AJ
authors.lastname: Ganc
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Ricardo Leite
authors.initials: RL
authors.lastname: Ganc
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Sílvia Mansur
authors.initials: SM
authors.lastname: Reimão
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Alberto
authors.initials: A
authors.lastname: Frisoli Junior
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Jacyr
authors.initials: J
authors.lastname: Pasternak
mesh_terms: D000369:Aged, 80 and over; D016360:Clostridioides difficile; D003967:Diarrhea / Q000382:microbiology / Q000628:therapy*; D020776:Endoscopes, Gastrointestinal / Q000592:standards*; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology / Q000628:therapy*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D008297:Male; D064307:Microbiota; D012008:Recurrence; D014184:Transplantation, Homologous / Q000379:methods; D016896:Treatment Outcome