title: Graft rinse prior to reperfusion in liver transplantation: literature review and online survey within the Eurotransplant community.
abstract: Graft rinse prior reperfusion in liver transplantation (LT) is believed to reduce the incidence of postreperfusion syndrome and improve clinical outcome. A MEDLINE search was performed to obtain a comprehensive review of the published literature dealing with graft rinse in LT. Moreover, all thirty-four LT centers in the Eurotransplant (ET) region were invited to participate in an online survey to whether or not graft rinse is performed and whether further research in the field is needed. Seventeen reports have been found to investigate graft rinse protocols in 1894 LT recipients. Eighteen of the thirty centers that participated in the online survey performed graft rinse prior reperfusion in LT. The most commonly used rinse solution was albumin. Nineteen centers stated interest in participating in a multicenter RCT in the field. The published literature does not provide concluding appraisal of the benefit of graft rinse in LT. Graft rinse protocols are not standardized and are based on personal experience. Appropriately designed clinical trials addressing the topic are demanded. The online survey appears to be a helpful tool for the evaluation of clinical practice and future research topics in the transplant community.
authors.affiliation: Department of General and Transplant Surgery, University of Heidelberg, Heidelberg, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Houben
authors.affiliation: Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
authors.forename: Giulia
authors.initials: G
authors.lastname: Manzini
authors.affiliation: Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Kremer
authors.affiliation: Department of General, Visceral and Vascular Surgery, Otto-von-Guericke University, Magdeburg, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Arend
authors.affiliation: Division of Transplantation, Department of Surgery, University of Vienna, Vienna, Austria.
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Berlakovich
authors.affiliation: Department of General, Thoracic, Vascular and Transplantation Surgery, University of Rostock, Rostock, Germany.
authors.forename: Ernst
authors.initials: E
authors.lastname: Klar
authors.affiliation: Department of General, Visceral and Transplant Surgery, Klinikum der Medizinischen Hochschule, Hannover, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Klempnauer
authors.affiliation: Department of Liver Transplant Surgery, University Clinic Saint-Luc, Bruxelles, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Lerut
authors.affiliation: Department of Transplant and Hepato-Biliary-Pancreatic Surgery, Johannes-Gutenberg-University, Mainz, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Otto
authors.affiliation: Department of Abdominal Transplant Surgery, University of Leuven, Leuven, Belgium.
authors.forename: Jacques
authors.initials: J
authors.lastname: Pirenne
authors.affiliation: Department of Transplant Surgery, University of Gent, Gent, Belgium.
authors.forename: Xavier
authors.initials: X
authors.lastname: Rogiers
authors.affiliation: Department of General, Visceral and Transplantation Surgery, University of Berlin, Berlin, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Seehofer
authors.affiliation: Department of General, Visceral and Cancer Surgery, University of Cologne, Köln, Germany.
authors.forename: Dirk L
authors.initials: DL
authors.lastname: Stippel
authors.affiliation: Department of General and Transplant Surgery, University of Heidelberg, Heidelberg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Schemmer
mesh_terms: D005060:Europe; D006801:Humans; D007249:Inflammation; D020407:Internet; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D015337:Multicenter Studies as Topic; D009926:Organ Preservation / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D015424:Reperfusion / Q000379:methods; D012996:Solutions; D011795:Surveys and Questionnaires
chemical_list: D012996:Solutions
keywords: eurotransplant survey; graft rinse; liver transplantation