title: [Primary cervical cancer screening].
abstract: Cervico-uterine cancer screening with cytology decrease incidence by more than 50%. The cause of this cancer is the human papilloma virus high risk, and requires a sensitive test to provide sufficient sensitivity and specificity for early detection and greater interval period when the results are negative. The test of the human papilloma virus high risk, is effective and safe because of its excellent sensitivity, negative predictive value and optimal reproducibility, especially when combined with liquid-based cytology or biomarkers with viral load, with higher sensitivity and specificity, by reducing false positives for the detection of cervical intraepithelial neoplasia grade 2 or greater injury, with excellent clinical benefits to cervical cancer screening and related infection of human papilloma virus diseases, is currently the best test for early detection infection of human papillomavirus and the risk of carcinogenesis.
authors.affiliation: Dirección de Investigación, Hospital Juárez de México D.F., México. Electronic address: vvargashernandez@yahoo.com.mx.
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: Vargas-Hernández
authors.affiliation: Hospital de Oncología, Centro Médico Nacional siglo XXI, Instituto Mexicano del Seguro Social, México.
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: Vargas-Aguilar
authors.affiliation: Dirección de Investigación, Hospital Juárez de México D.F., México.
authors.forename: José María
authors.initials: JM
authors.lastname: Tovar-Rodríguez
mesh_terms: D014408:Biomarkers, Tumor; D015344:DNA Probes, HPV; D055088:Early Detection of Cancer / Q000379:methods* / Q000639:trends; D005260:Female; D005814:Genes, Viral; D019942:Genes, p16; D006293:Health Promotion; D006801:Humans; D015994:Incidence; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D009856:Oncogene Proteins, Viral / Q000235:genetics; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D014626:Vaginal Smears; D019562:Viral Load; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000821:virology
chemical_list: D014408:Biomarkers, Tumor; D015344:DNA Probes, HPV; D009856:Oncogene Proteins, Viral
keywords: Biomarcadores; Biomarkers; Cervical intraepithelial neoplasia virus; Human papillomavirus high-risk; Methods of early detection of cervical cancer; Métodos de detección oportuna de cáncer cervicouterino; Neoplasias intraepiteliales cervicales; Virus del papiloma humano de alto riesgo