title: Adjunctive Effects of A Piscean Collagen-Based Controlled-Release Chlorhexidine Chip in the Treatment of Chronic Periodontitis: A Clinical and Microbiological Study.
abstract: BACKGROUND
  PerioChip a bovine origin gelatine based CHX chip has shown beneficial effects in the management of Chronic Periodontitis. A new fish collagen based CHX chip similar to PerioChip is currently available; however this product has not been thoroughly researched.
  
  
  OBJECTIVE
  The aim of the present study was to evaluate the effectiveness of a new Piscean collagen-based controlled-release chlorhexidine chip (CHX chip) as an adjunctive therapy to scaling and root planing (SRP).
  
  
  METHODS
  The study was conducted as a randomised, split-mouth, controlled clinical trial at Krishnadevaraya College of Dental Sciences, Bangalore, India.
  
  
  METHODS
  In a split-mouth study involving 20 sites in 10 patients with chronic periodontitis, control sites received scaling and root planing and test sites received scaling and root planing (SRP) and the intrapocket CHX chip placement as an adjunct. Subgingival plaque samples were collected from both control and test sites at baseline, 11 days and 11 weeks and the anaerobic colony count were assessed. Clinical parameters that were recorded at baseline and 11 weeks were gingival index, Plaque index, Probing pocket depth (PPD), and Clinical attachment level (CAL). Plaque index was recorded additionally at 11 days.
  
  
  RESULTS
  In the test group there was a statistically significant reduction in the total anaerobic colony count, gingival index and plaque scores from baseline as compared to control sites at all time intervals. An additional 0.8mm reduction in mean probing pocket depth was noted in the test group. Gain in Clinical attachment level was comparable in both groups.
  
  
  CONCLUSIONS
  The adjunctive use of the new collagen-based CHX chip yielded significant antimicrobial benefit accompanied by a reduction in probing depth and a clinical attachment level gain as compared to SRP alone. This suggests that it may be a useful treatment option of nonsurgical periodontal treatment of chronic periodontitis.
authors.affiliation: Senior Lecturer, Mar Baselious Dental College , Kothamangalam, Kerala, India.
authors.forename: Priya
authors.initials: P
authors.lastname: John
authors.affiliation: Former Professor and HOD, Department of Periodontology, Best Dental College , Madurai, India .
authors.forename: Flemingson
authors.initials: F
authors.lastname: Lazarus
authors.affiliation: Professor, Department of Periodontics, Krishnadevaraya College of Dental Sciences , Bangalore, India .
authors.forename: Joann Pauline
authors.initials: JP
authors.lastname: George
authors.affiliation: Professor and HOD, Department of Microbiology, Krishnadevaraya College of Dental Sciences , Bangalore, India .
authors.forename: Arul
authors.initials: A
authors.lastname: Selvam
authors.affiliation: Professor and HOD, Department of Periodontics, Krishnadevaraya College of Dental Sciences , Bangalore, India .
authors.forename: Munivenkatappa Lakshmaiah Venkatesh
authors.initials: ML
authors.lastname: Prabhuji
keywords: Chlorhexidine; Chronic periodontitis; Dental plaque; Drug delivery systems; Microbiological analysis