title: Clinical Outcomes in Patients with Parkinson's Disease Treated with a Monoamine Oxidase Type-B inhibitor: A Cross-Sectional, Cohort Study.
abstract: OBJECTIVE
  To evaluate the long-term risk of developing cognitive symptoms (e.g., dementia, hallucinations), dyskinesia, falls, and freezing of gait (FoG) in patients with Parkinson's disease (PD) who received monoamine oxidase type B inhibitors (MAOB-Is) compared with patients who had never received MAOB-Is.
  
  
  METHODS
  Retrospective, cross-sectional, cohort study.
  
  
  METHODS
  Academic movement disorders clinic.
  
  
  METHODS
  One hundred eighty-one patients with idiopathic PD who were receiving MAOB-I therapy on a long-term basis for a minimum of 1 year (MAOB-I current-user cohort) and 121 patients with idiopathic PD who had never received MAOB-I therapy (MAOB-I never-user cohort [control group]) between January 1, 1996, and November 30, 2011.
  
  
  RESULTS
  The five study outcome variables were dementia, dyskinesia, falls, FoG, and hallucinations. Baseline and outcome data were collected from medical records. Patients in the MAOB-I current-user group were included only if absence of the specified outcomes was documented at baseline. Adjusted multiple logistic regression analyses were performed to calculate the odds ratios (ORs) for MAOB-I use versus never use on clinical outcomes. MAOB-I treatment was associated with a 44.7% reduced risk of dyskinesia (adjusted OR 0.553, 95% confidence interval 0.314-0.976, p=0.041), with the greatest risk reduction observed after 2 years of treatment. No significant association was noted with MAOB-I use and development of dementia, falls, FoG, or hallucinations.
  
  
  CONCLUSIONS
  Long-term use of MAOB-I therapy was associated with reduced risk of dyskinesia in patients with PD.
authors.affiliation: School of Medicine, Loma Linda University, Loma Linda, California.
authors.forename: Khashayar
authors.initials: K
authors.lastname: Dashtipour
authors.affiliation: School of Medicine, Loma Linda University, Loma Linda, California.|College of Pharmacy, Marshall B. Ketchum University, Fullerton, California.
authors.forename: Jack J
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: School of Medicine, Loma Linda University, Loma Linda, California.
authors.forename: Camellia
authors.initials: C
authors.lastname: Kani
authors.affiliation: School of Public Health, Loma Linda University, Loma Linda, California.
authors.forename: Khaled
authors.initials: K
authors.lastname: Bahjri
authors.affiliation: School of Public Health, Loma Linda University, Loma Linda, California.
authors.forename: Mark
authors.initials: M
authors.lastname: Ghamsary
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D020820:Dyskinesias / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D012189:Retrospective Studies
chemical_list: D008996:Monoamine Oxidase Inhibitors
keywords: Parkinson's disease; dyskinesia; monoamine oxidase inhibitor; rasagiline; selegiline