title: Cutaneous Adverse Events in Chronic Hepatitis C Patients Treated With New Direct-Acting Antivirals: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Direct-acting antivirals (DAAs) are known to present with additional dermatological events over pegylated-interferon/ribavirin (Peg-IFN/RBV).
  
  
  OBJECTIVE
  A systematic review and meta-analysis was conducted to assess the incidence/risk of cutaneous adverse events (AEs) for simeprevir, sofosbuvir, ABT450/r-ombitasvir, dasabuvir, ledipasvir, daclatasvir, and asunaprevir.
  
  
  METHODS
  The databases searched included PubMed, Clinicaltrials.gov, and Clinicaloptions.com. Data on telaprevir and boceprevir were obtained from a previous study.
  
  
  RESULTS
  The incidences of cutaneous AEs were 34.3% (95% CI 18.4%-54.8%) for the old DAAs + Peg-IFN/RBV, 22.0% (95% CI 17.9%-26.8%) for the new DAAs + Peg-IFN/RBV, 9.8% (95% CI 8.6%-11.2%) for the DAAs + RBV, and 3.8% (95% CI 2.4%-6.1%) for DAAs only. Simeprevir + Peg-IFN/RBV was associated with an increased relative risk over Peg-IFN/RBV; RR = 1.319 (95% CI 1.026-1.697).
  
  
  CONCLUSIONS
  Dermatological events are still an important issue for many of the new DAAs. Appropriate monitoring, management, and patient education are needed to minimize AEs and achieve HCV cure.
authors.affiliation: Department of Medicine, Division of Dermatology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Parth
authors.initials: P
authors.lastname: Patel
authors.affiliation: College of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Kunal
authors.initials: K
authors.lastname: Malik
authors.affiliation: Department of Medicine, Division of Dermatology, Albert Einstein College of Medicine, Bronx, NY, USA kkderm@gmail.com.
authors.forename: Karthik
authors.initials: K
authors.lastname: Krishnamurthy
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D012871:Skin Diseases / Q000139:chemically induced*
chemical_list: D000998:Antiviral Agents
keywords: dermatitis; dermatology; immunology; infectious disease