title: A self-regulating antimicrobial model based on the ion-exchange stimuli.
abstract: In this study, a novel intelligent antimicrobial model was constructed based on the antibiotic properties of nano-silver and the ion-exchange response of dehydrated alginate (Alg) gel. Through the process of reducing reaction, hydrogel formation and dehydration, the model composed of Alg and nano-silver was fabricated. The distinguished feature of this model lies in its antimicrobial properties and biocompatibility. In this model, the releasing level of nano-silver is determined by the outside-in swelling of Alg composites, which is further self-regulated by the volume of wound exudates. The results showed that the released nano-silver was intelligently maintained within a constant concentration range, so that it could be further designed to exhibit antimicrobial activity without cytotoxicity. Furthermore, the murine wound infection model conducted with these composites resulted in a significant decrease of bacteria number. The self-regulating swelling feature based on the ion-exchange response of Alg along with the controlled release of nano-silver made this composite a promising intelligent model for antimicrobial wound dressing applications.
authors.affiliation: Research Institute of Surface Engineering, Taiyuan University of Technology, 79 Yingze Road, Taiyuan, 030024, People's Republic of China, huangtyut@163.com.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Huang
authors.forename: Yinping
authors.initials: Y
authors.lastname: Liu
authors.forename: Chengliang
authors.initials: C
authors.lastname: Chang
authors.forename: Longan
authors.initials: L
authors.lastname: Jiao
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Hang
authors.forename: Bin
authors.initials: B
authors.lastname: Tang
mesh_terms: D016475:3T3 Cells; D000464:Alginates / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007475:Ion Exchange Resins; D053768:Metal Nanoparticles; D051379:Mice; D012834:Silver / Q000737:chemistry
chemical_list: D000464:Alginates; D000890:Anti-Infective Agents; D006603:Hexuronic Acids; D007475:Ion Exchange Resins; D012834:Silver; D020723:Glucuronic Acid