title: Intraductal papillary mucinous neoplasm of the ileal heterotopic pancreas in a patient with hereditary non-polyposis colorectal cancer: A case report.
abstract: We report a case of intraductal papillary mucinous neoplasm (IPMN) originating from the ileal heterotopic pancreas in a patient with hereditary non-polyposis colorectal cancer (HNPCC). A 49-year-old woman had a past history of total colectomy and total hysterectomy with bilateral salpingo-oophorectomy due to colonic adenocarcinoma and endometrial adenocarcinoma 11 years ago. Her parents died from colonic adenocarcinoma and her sister died from colonic adenocarcinoma and endometrial adenocarcinoma. The clinician found an ileal mass with necrotic change and the mass increased in size from 1.7 cm to 2.2 cm during the past 2 years on computed tomography. It was surgically resected. Microscopically, the ileal mass showed heterotopic pancreas with IPMN high grade dysplasia. Immunohistochemical staining revealed positive reactivity for MLH1/PMS2 and negative reactivity for MSH2/MSH6. This is the first report of IPMN originating from the ileal heterotopic pancreas in a patient with HNPCC in the English literature.
authors.affiliation: Sang Hwa Lee, Wook Youn Kim, Hye Seung Han, Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, South Korea.
authors.forename: Sang Hwa
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Sang Hwa Lee, Wook Youn Kim, Hye Seung Han, Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, South Korea.
authors.forename: Wook Youn
authors.initials: WY
authors.lastname: Kim
authors.affiliation: Sang Hwa Lee, Wook Youn Kim, Hye Seung Han, Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, South Korea.
authors.forename: Dae-Yong
authors.initials: DY
authors.lastname: Hwang
authors.affiliation: Sang Hwa Lee, Wook Youn Kim, Hye Seung Han, Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, South Korea.
authors.forename: Hye Seung
authors.initials: HS
authors.lastname: Han
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002828:Choristoma; D003082:Colectomy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005260:Female; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D007078:Ileal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D007150:Immunohistochemistry; D008875:Middle Aged; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010179:Pancreas; D010190:Pancreatic Neoplasms; D010641:Phenotype; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor
keywords: Choristoma; Colorectal neoplasms; Hereditary nonpolyposis; Pancreatic neoplasms