title: A Spectroscopy Approach for the Study of the Interaction of Oxovanadium(IV)-Salen Complexes with Proteins.
abstract: Oxovanadium(IV)-salen complexes bind with bovine serum albumin (BSA) and ovalbumin (OVA) strongly with binding constant in the range 10(4)-10(7) M(-1) at physiological pH (7.4) confirmed using UV-visible absorption, fluorescence spectral and circular dichroism (CD) study. CD results show that the binding of oxovanadium(IV) complexes induces the conformational change with the loss of α-helicity in the proteins. Docking studies indicate that mode of binding of oxovanadium(IV)-salen complexes with proteins is hydrophobic in nature.
authors.affiliation: Department of Chemistry, V. O. Chidambaram College, Tuticorin, 628 008, India.
authors.forename: Alagarsamy
authors.initials: A
authors.lastname: Mathavan
authors.forename: Arumugam
authors.initials: A
authors.lastname: Ramdass
authors.forename: Seenivasan
authors.initials: S
authors.lastname: Rajagopal
mesh_terms: D000818:Animals; D002417:Cattle; D002942:Circular Dichroism; D005029:Ethylenediamines / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D062105:Molecular Docking Simulation; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*; D010047:Ovalbumin / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D017433:Protein Structure, Secondary; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013816:Thermodynamics; D017968:Vanadium Compounds / Q000737:chemistry / Q000378:metabolism*
chemical_list: D005029:Ethylenediamines; D009942:Organometallic Compounds; D017968:Vanadium Compounds; D012710:Serum Albumin, Bovine; D010047:Ovalbumin; C011452:disalicylaldehyde ethylenediamine