title: Oxygen deteriorates arterial function in type 1 diabetes.
abstract: OBJECTIVE
  Although oxygen is commonly used to treat various medical conditions, it has recently been shown to worsen vascular function (arterial stiffness) in healthy volunteers and even more in patients in whom vascular function might already be impaired. The effects of oxygen on arterial function in patients with type 1 diabetes (T1D) are unknown, although such patients display disturbed vascular function already at rest. Therefore, we tested whether short-term oxygen administration may alter the arterial function in patients with T1D.
  
  
  METHODS
  We estimated arterial stiffness by augmentation index (AIx) and the pulse wave velocity equivalent (SI-DVP) in 98 patients with T1D and 49 age- and sex-matched controls at baseline and during hyperoxia by obtaining continuous noninvasive finger pressure waveforms using a recently validated method.
  
  
  RESULTS
  AIx and SI-DVP increased in patients (P < 0.05) but not in controls in response to hyperoxia. The increase in AIx (P = 0.05), systolic (P < 0.05), and diastolic (P < 0.05) blood pressure was higher in the patients than in the controls.
  
  
  CONCLUSIONS
  Short-term oxygen administration deteriorates arterial function in patients with T1D compared to non-diabetic control subjects. Since disturbed arterial function plays a major role in the development of diabetic complications, these findings may be of clinical relevance.
authors.affiliation: Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, POB 63, 00014, Helsinki, Finland.|Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.|Diabetes and Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gordin
authors.affiliation: Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, POB 63, 00014, Helsinki, Finland.|Department of Internal Medicine, University of Pavia, Pavia, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Bernardi
authors.affiliation: Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, POB 63, 00014, Helsinki, Finland.|Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.|Diabetes and Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland.
authors.forename: Milla
authors.initials: M
authors.lastname: Rosengård-Bärlund
authors.affiliation: South Australian Health and Medical Research Institute, Adelaide, SA, Australia.|School of Biomedical and Molecular Science, University of Adelaide, Adelaide, SA, Australia.
authors.forename: Ville-Petteri
authors.initials: VP
authors.lastname: Mäkinen
authors.affiliation: Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, POB 63, 00014, Helsinki, Finland.|Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.|Diabetes and Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland.
authors.forename: Aino
authors.initials: A
authors.lastname: Soro-Paavonen
authors.affiliation: Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, POB 63, 00014, Helsinki, Finland.|Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.|Diabetes and Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland.
authors.forename: Carol
authors.initials: C
authors.lastname: Forsblom
authors.affiliation: Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, POB 63, 00014, Helsinki, Finland.|Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.|Diabetes and Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Sandelin
authors.affiliation: Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, POB 63, 00014, Helsinki, Finland. per-henrik.groop@helsinki.fi.|Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. per-henrik.groop@helsinki.fi.|Diabetes and Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland. per-henrik.groop@helsinki.fi.|The Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia. per-henrik.groop@helsinki.fi.
authors.forename: Per-Henrik
authors.initials: PH
authors.lastname: Groop
mesh_terms: D000328:Adult; D001158:Arteries / Q000187:drug effects*; D001794:Blood Pressure; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen / Q000008:administration & dosage / Q000009:adverse effects*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects*; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
chemical_list: D010100:Oxygen
keywords: Augmentation index; Blood pressure; Hyperoxia; Oxygen; Pulse wave velocity; Type 1 diabetes