title: [Watermelon stomach: Chronic renal failure and/or imatinib?].
abstract: Watermelon stomach or gastric antral vascular ectasia (GAVE) syndrome is an uncommon cause of sometimes severe upper gastro-intestinal bleeding. Essentially based on a pathognomonic endoscopic appearance, its diagnosis may be unrecognised because mistaken with portal hypertensive gastropathy, while treatment of these two entities is different. Its etiopathogeny remains still unclear, even if it is frequently associated with different systemic illnesses as hepatic cirrhosis, autoimmune disorders and chronic renal failure. The mechanism inducing these vascular ectasia may be linked with mechanical stress on submucosal vessels due to antropyloric peristaltic motility dysfunction modulated by neurohormonal vasoactive alterations. Because medical therapies are not very satisfactory, among the endoscopic modalities, argon plasma coagulation seems to be actually the first-line treatment because the most effective and safe. However, surgical antrectomy may be sometimes necessary. Recently GAVE syndrome appeared as a new adverse reaction of imatinib mesylate, one of the tyrosine kinase inhibitors used in chronic myeloid leukemia, and we report here the observation of such a pathology in one patient treated at the same time by haemodialysis and by imatinib mesylate for chronic myeloid leukemia.
authors.affiliation: Service de néphrologie hémodialyse, centre hospitalier de Troyes, 101, avenue Anatole-France, 10003 Troyes cedex, France. Electronic address: richard.montagnac@ch-troyes.fr.
authors.forename: Richard
authors.initials: R
authors.lastname: Montagnac
authors.affiliation: Service de gastroentérologie, centre hospitalier de Troyes, 101, avenue Anatole-France, 10003 Troyes cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Blaison
authors.affiliation: Service d'hématologie, centre hospitalier de Troyes, 101, avenue Anatole-France, 10003 Troyes cedex, France.
authors.forename: Saïd
authors.initials: S
authors.lastname: Brahimi
authors.affiliation: Service de néphrologie hémodialyse, centre hospitalier de Troyes, 101, avenue Anatole-France, 10003 Troyes cedex, France.
authors.forename: Adeline
authors.initials: A
authors.lastname: Schendel
authors.affiliation: Service de néphrologie hémodialyse, centre hospitalier de Troyes, 101, avenue Anatole-France, 10003 Troyes cedex, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Levasseur
authors.affiliation: Laboratoire d'anatomie pathologique, centre hospitalier de Troyes, 101, avenue Anatole-France, 10003 Troyes cedex, France.
authors.forename: Romulus
authors.initials: R
authors.lastname: Takin
mesh_terms: D020252:Gastric Antral Vascular Ectasia / Q000139:chemically induced* / Q000628:therapy; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D005773:Gastroscopy; D006801:Humans; D000068877:Imatinib Mesylate / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy*; D008297:Male; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D006435:Renal Dialysis
chemical_list: D047428:Protein Kinase Inhibitors; D000068877:Imatinib Mesylate
keywords: Anémie ferriprive; Argon plasma coagulation; Chronic renal failure; Coagulation par plasma argon; Ectasies vasculaires; Gastrointestinal bleeding; Glivec(®); Hémorragie digestive; Imatinib mesylate; Insuffisance rénale chronique; Iron deficiency anemia; Vascular ectasia; Watermelon stomach