title: Sarcoidosis of the pleura--A case report.
abstract: BACKGROUND
  Pleural involvement is an uncommon manifestation of sarcoidosis. It may manifest as pleural effusion, pneumothorax, pleural thickening and nodules, hydropneumothorax, trapped lung, hemothorax, or chylothorax. The incidence of pleural effusion with sarcoidosis ranges from 0% to 5% but has been reported to be as high as 7.5%. Pleural effusions complicate sarcoidosis in < 3% of patients.
  
  
  METHODS
  We reported a 64-year-old male patient with chronic multiorgan sarcoidosis. This patient developed pleural sarcoidosis with massive pleural effusion several years after the diagnosis of sarcoidosis. A definitive diagnosis of a sarcoid pleural effusion was based on a biopsy demonstrating noncaseating granuloma. The patient responded well to the treatment (methotrexate and methylprednisolone) with a complete withdrawal of pleural effusion following five weeks of the treatment beginning.
  
  
  CONCLUSIONS
  The presented patient is a rare case of pleural involvement of sarcoidosis with massive effusion, who responded well to the treatment.
authors.forename: Dragana
authors.initials: D
authors.lastname: Jovanović
authors.forename: Violeta
authors.initials: V
authors.lastname: Vučinić
authors.forename: Ruža
authors.initials: R
authors.lastname: Stević
authors.forename: Marina Roksandić
authors.initials: MR
authors.lastname: Milenkovic
authors.forename: Natalija
authors.initials: N
authors.lastname: Samardžić
authors.forename: Marta
authors.initials: M
authors.lastname: Velinović
authors.forename: Mihailo
authors.initials: M
authors.lastname: Stjepanović
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010995:Pleural Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate