title: Dementia is associated with open-angle glaucoma: a population-based study.
abstract: OBJECTIVE
  Previous epidemiologic studies that focused on the association between open-angle glaucoma (OAG) and dementia showed inconsistent results. In the present study, we explored the association between OAG and dementia in an ethnic Chinese (i.e., Taiwanese) population using a population-based data set.
  
  
  METHODS
  We retrieved data on study subjects for this case-control study from the Longitudinal Health Insurance Database 2000. We identified 7770 patients who had a diagnosis of dementia as cases, and 7770 subjects matched in terms of sex and age, which were randomly extracted as controls. A conditional logistic regression conditioned on age group, sex, and index year was used to assess the association of dementia with previously diagnosed OAG among the sampled patients.
  
  
  RESULTS
  Of 15,540 patients, 1.70% had prior OAG, including 2.02% of the dementia group and 1.38% of the controls. After adjusting for patient socioeconomic characteristics and comorbid medical disorders, dementia patients were more likely to have had prior OAG than controls (odds ratio (OR): 1.44; 95% confidence interval (CI): 1.12-1.85; P<0.01). In addition, female dementia patients were more likely to have had prior OAG than controls (OR: 1.93; 95% CI: 1.35-2.77; P<0.001), whereas no statistical difference in prior OAG between male dementia patients and controls was found.
  
  
  CONCLUSIONS
  Female dementia patients were associated with a higher proportion of prior OAG than were the controls.
authors.affiliation: Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan.|Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: S-D
authors.initials: SD
authors.lastname: Chung
authors.affiliation: Department of Ophthalmology, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: J D
authors.initials: JD
authors.lastname: Ho
authors.affiliation: Department of Thoracic Surgery, Mackay Memorial Hospital, Taipei, Taiwan.|Mackay Medicine, Nursing, and Management College, Taipei, Taiwan.
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.|School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.affiliation: School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.|Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan.
authors.forename: M C
authors.initials: MC
authors.lastname: Tsai
authors.affiliation: Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan.|Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: J J
authors.initials: JJ
authors.lastname: Sheu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000453:epidemiology; D044466:Asian People / Q000208:ethnology; D016022:Case-Control Studies; D016208:Databases, Factual; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D009313:National Health Programs / Q000706:statistics & numerical data; D016017:Odds Ratio; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology