title: An Extraordinary Case Associated with an Allergic Reaction to Clopidogrel: Coronary Artery Spasm or Kounis Syndrome?
abstract: Kounis syndrome is the concurrence of acute coronary syndrome with allergic reactions, such as anaphylaxis or anaphylactoid reactions. Here, we describe a unique case: CASs (coronary artery spasms) with both non-hypersensitivity and hypersensitivity aetiology (associated with clopidogrel hypersensitivity) were observed in a 61 year-old patient. Herein, the mechanism and clinical implications of this association are discussed.
authors.affiliation: Department of Emergency Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Liping
authors.affiliation: Department of Pharmacology, Shanghai Academy of Health Sciences.
authors.forename: Hui
authors.initials: H
authors.lastname: Bin
authors.affiliation: Department of Emergency Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address: sun_zlp@sina.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Qiming
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D000077144:Clopidogrel; D003329:Coronary Vasospasm / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000077144:Clopidogrel; D013988:Ticlopidine
keywords: Allergic reaction; Clopidogrel; Coronary artery spasm; Kounis syndrome