title: Association investigation ofBACH2rs3757247 andSOD2rs4880 polymorphisms with the type 1 diabetes and diabetes long-term complications risk in the Polish population.
abstract: Genetic factors are indicated in the development of type 1 diabetes (DM1). Recently, nucleotide variants ofBACH2andSOD2have been associated with this chronic condition. Therefore, the purpose of the present study was to investigate the contribution ofBACH2rs3757247 andSOD2rs4880 (Ala16Val) polymorphisms to the risk of DM1 and diabetes long-term complications. Selected polymorphic variants ofBACH2andSOD2were investigated in a group of 141 patients with DM1 and in a group of age, gender-matched healthy subjects (n=369) using a high-resolution melting curve method. There was no evidence for either allelic or genotypic association with the risk of DM1 and diabetes chronic complications for analysed polymorphisms. In addition, no interaction betweenBACH2andSOD2variants in the development of this condition was observed. However, the frequency ofBACH2rs3757247 AG and AA genotypes was statistically different between DM1 patients with retinopathy and healthy individuals (odds ratio, 2.455; 95% confidence interval, 0.999-6.035; P=0.044), but this result did not survive multiple testing corrections. The present study did not confirm the involvement ofBACH2rs3757247 andSOD2rs4880 polymorphisms in the development of DM1 and diabetes long-term complications. Further studies in a larger population sample are required.
authors.affiliation: Lipid Metabolism Laboratory, Department of General Chemistry, Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Poznan 60-780, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wegner
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan 60-781, Poland.
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mostowska
authors.affiliation: Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan 60-843, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Araszkiewicz
authors.affiliation: Department of Pharmaceutical Sciences, Texas A&M Health Science Center College of Pharmacy, Kingsville 78363, TX, USA.
authors.forename: Mahua
authors.initials: M
authors.lastname: Choudhury
authors.affiliation: Department of Clinical Biochemistry and Laboratory Medicine, Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Poznan 60-780, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Piorunska-Stolzmann
authors.affiliation: Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan 60-843, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Zozulinska-Ziolkiewicz
authors.affiliation: Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan 60-843, Poland.
authors.forename: Bogna
authors.initials: B
authors.lastname: Wierusz-Wysocka
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan 60-781, Poland.
authors.forename: Pawel P
authors.initials: PP
authors.lastname: Jagodzinski
keywords: BACH2 rs3757247 polymorphism; SOD2 rs4880 polymorphism; type 1 diabetes