title: Whole Brain ¹H-Spectroscopy: A Developing Technique for Advanced Analysis of Cerebral Metabolism.
abstract: OBJECTIVE
  Accompanying the advance of neuroscientific research and modern therapeutic methods, efforts have been made to develop more practical and effective advanced magnetic resonance (MR) spectroscopic techniques.
  
  
  METHODS
  We present a brief overview on (1)H-MRS techniques in neuroradiological diagnosis and several application examples of recently reported whole brain MR spectroscopic imaging technique (wbMRSI).
  
  
  RESULTS
  Despite the benefits of using established (1)H-MRS techniques both single voxel MR spectroscopy (SVS) and chemical shift imaging (CSI) techniques suffer from limited spatial coverage. It is always necessary to define prior to the MRS examination which brain structure is physiologically or pathologically involved and thus should be targeted with (1)H-MRS. In contrast, the advanced wbMRSI allows estimating metabolite changes within a much larger brain region and at multiple brain structures simultaneously.
  
  
  CONCLUSIONS
  As a developing technique for advanced analysis of cerebral metabolism a wide application of the wbMRSI in both clinical diagnostics and neuroscience could be expected.
authors.affiliation: Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. ding.xiaoqi@mh-hannover.de.
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Ding
authors.affiliation: Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. ding.xiaoqi@mh-hannover.de.
authors.forename: H
authors.initials: H
authors.lastname: Lanfermann
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Brain metabolite; Chemical shift imaging; Single voxel spectroscopy; Whole brain MR spectroscopic imaging