title: Histone deacetylases: Targets for antifungal drug development.
abstract: The interaction of pathogens and its hosts causes a drastic change in the transcriptional landscape in both cells. Among the several mechanisms of gene regulation, transcriptional initiation is probably the main point. In such scenario, the access of transcriptional machinery to promoter is highly regulated by post-translational modification of histones, such as acetylation, phosphorylation and others. Inhibition of histone deacetylases is able to reduce fungal pathogens fitness during infection and, therefore, is currently being considered for the development of new antifungal therapy strategies.
authors.affiliation: a Programa de Pós-Graduação em Biologia Celular e Molecular; Centro de Biotecnologia; UFRGS ; Porto Alegre , Brazil.|b Departamento de Biologia Molecular e Biotecnologia ; Instituto de Biociências; UFRGS ; Porto Alegre , Brazil.
authors.forename: Livia
authors.initials: L
authors.lastname: Kmetzsch
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D055808:Drug Discovery / Q000639:trends; D005658:Fungi / Q000187:drug effects* / Q000201:enzymology*; D015966:Gene Expression Regulation, Fungal; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans
chemical_list: D000935:Antifungal Agents; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases
keywords: Cryptococcus neoformans; fungal pathogens; histone deacetylases; histone deacetylases inhibitors; sodium butyrate; trichostatin A