title: Reincarnation of ancient links between coagulation and complement.
abstract: Throughout evolution, organisms have developed means to contain wounds by simultaneously limiting bleeding and eliminating pathogens and damaged host cells via the recruitment of innate defense mechanisms. Disease emerges when there is unchecked activation of innate immune and/or coagulation responses. A key component of innate immunity is the complement system. Concurrent excess activation of coagulation and complement - two major blood-borne proteolytic pathways - is evident in numerous diseases, including atherosclerosis, diabetes, venous thromboembolic disease, thrombotic microangiopathies, arthritis, cancer, and infectious diseases. Delineating the cross-talk between these two cascades will uncover novel therapeutic insights.
authors.affiliation: Centre for Blood Research, Life Sciences Institute, Division of Hematology, Department of Medicine, Faculty of Medicine, University of British Columbia (UBC), Vancouver, BC, Canada.
authors.forename: E M
authors.initials: EM
authors.lastname: Conway
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002450:Cell Communication; D003167:Complement Activation; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D015398:Signal Transduction
chemical_list: D001779:Blood Coagulation Factors; D003165:Complement System Proteins
keywords: endothelial cells; innate immunity; platelet; thrombosis; thrombotic microangiopathy