title: Short and highly efficient synthesis of lipid peroxidation inhibitor pyrrolostatin and some analogues thereof.
abstract: A highly efficient and scalable synthesis of potent lipid peroxidation inhibitor pyrrolostatin is reported (4 steps, 48%). In addition to the synthesis of the natural product, strategies for the preparation of analogues differing in the three structural subunits, the polar head group, the N-substituent and the lipophilic tail are described.
authors.affiliation: Fachbereich Chemie, Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany. stark@chemie.unihamburg.de.
authors.forename: Jens
authors.initials: J
authors.lastname: Schmidt
authors.forename: Juliane
authors.initials: J
authors.lastname: Adrian
authors.lastname: Christian B W Stark
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D005227:Fatty Acids / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D012997:Solvents / Q000737:chemistry
chemical_list: D005227:Fatty Acids; D012997:Solvents; C013584:lipid peroxidation inhibitor; C082418:pyrrolostatin; D011392:Proline