title: Co-evolutionary constraints of globular proteins correlate with their folding rates.
abstract: Folding rates (lnkf) of globular proteins correlate with their biophysical properties, but relationship between lnkf and patterns of sequence evolution remains elusive. We introduce 'relative co-evolution order' (rCEO) as length-normalized average primary chain separation of co-evolving pairs (CEPs), which negatively correlates with lnkf. In addition to pairs in native 3D contact, indirectly connected and structurally remote CEPs probably also play critical roles in protein folding. Correlation between rCEO and lnkf is stronger in multi-state proteins than two-state proteins, contrasting the case of contact order (co), where stronger correlation is found in two-state proteins. Finally, rCEO, co and lnkf are fitted into a 3D linear correlation.
authors.affiliation: Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, India; Center of Excellence in Systems Biology and Biomedical Engineering (TEQIP Phase-II), University of Calcutta, India.
authors.forename: Saurav
authors.initials: S
authors.lastname: Mallik
authors.affiliation: Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, India; Center of Excellence in Systems Biology and Biomedical Engineering (TEQIP Phase-II), University of Calcutta, India. Electronic address: skbmbg@caluniv.ac.in.
authors.forename: Sudip
authors.initials: S
authors.lastname: Kundu
mesh_terms: D000465:Algorithms; D005075:Biological Evolution; D030562:Databases, Protein; D007700:Kinetics; D016014:Linear Models; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D011506:Proteins
keywords: Co-evolution; Contact order; Protein folding; Relative co-evolution order