title: Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.
abstract: We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Kaimin
authors.initials: K
authors.lastname: Cai
authors.affiliation: Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Yen
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yin
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lezmi
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Xujuan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: William G
authors.initials: WG
authors.lastname: Helferich
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA ; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects*; D002626:Chemistry, Pharmaceutical; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D061986:MCF-7 Cells / Q000737:chemistry / Q000187:drug effects*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D017239:Paclitaxel / Q000737:chemistry / Q000627:therapeutic use*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D011108:Polymers; D011092:Polyethylene Glycols; D004317:Doxorubicin; D017239:Paclitaxel