title: Evaluation of Tl-201 SPECT imaging findings in prostate cancer.
abstract: OBJECTIVE
  To compare with histopathological findings the findings of prostate cancer imaging by SPECT method using Tl-201 as a tumor seeking agent.
  
  
  METHODS
  The study comprised 59 patients (age range 51-79 years, mean age 65.3 ± 6.8 years) who were planned to have transrectal ultrasonography (TRUS)-guided biopsies due to suspicion of prostate cancer between April 2011 and September 2011. Early planar, late planar and SPECT images were obtained for all patients. Scintigraphic evaluation was made in relation to uptake presence and patterns in the visual assessment and to Tumor/Background (T/Bg) ratios for both planar and SPECT images in the quantitative assessment. Histopathological findings were compatible with benign etiology in 36 (61%) patients and malign etiology in 23 (39%) patients. Additionally, comparisons were made to evaluate the relationships between uptake patterns,total PSA values and Gleason scores.
  
  
  RESULTS
  A statistically significant difference was found between the benign and malignant groups in terms of uptake in planar and SPECT images and T/Bg ratios and PSA values. No statistically significant difference was found between uptake patterns of planar and SPECT images and Gleason scores in the malignant group.
  
  
  CONCLUSIONS
  SPECT images were superior to planar images in the comparative assessment. Tl-201 SPECT imaging can provide an additional contribution to clinical practice in the diagnosis of prostate cancer and it can be used in selected patients.
authors.affiliation: Dr. Sami Ulus Training and Research Hospital, Department of Nuclear Medicine, Van. drberkan79@gmail.com.
authors.forename: Sinem
authors.initials: S
authors.lastname: Ozyurt
authors.forename: Gokhan
authors.initials: G
authors.lastname: Koca
authors.forename: Akif
authors.initials: A
authors.lastname: Diri
authors.forename: Koray
authors.initials: K
authors.lastname: Demirel
authors.forename: Tolga
authors.initials: T
authors.lastname: Karakan
authors.forename: Berkan
authors.initials: B
authors.lastname: Resorlu
authors.forename: Meliha
authors.initials: M
authors.lastname: Korkmaz
authors.forename: Cankon
authors.initials: C
authors.lastname: Germiyanoglu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D013794:Thallium Radioisotopes; D017430:Prostate-Specific Antigen