title: Biocompatible films with tailored spectral response for prevention of DNA damage in skin cells.
abstract: A hybrid nanostructured organic-in-organic biocompatible film capable of efficiently blocking a preselected range of ultraviolet light is designed to match the genotoxic action spectrum of human epithelial cells. This stack protects cultured human skin cells from UV-induced DNA lesions. As the shielding mechanism relies exclusively on reflection, the secondary effects due to absorption harmful radiation are prevented.
authors.affiliation: Synthetic Biology and Smart Therapeutic Systems Group, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), Parque Tecnológico de Andalucía, C/Severo Ochoa 35, 29590, Campanillas, Málaga, Spain.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Núñez-Lozano
authors.affiliation: Synthetic Biology and Smart Therapeutic Systems Group, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), Parque Tecnológico de Andalucía, C/Severo Ochoa 35, 29590, Campanillas, Málaga, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Pimentel
authors.affiliation: Multifunctional Optical Materials Group, Institute of Materials Science of Sevilla, Spanish National Research Council-University of Seville, C/Américo Vespucio 49, 41092, Sevilla, Spain.
authors.forename: José R
authors.initials: JR
authors.lastname: Castro-Smirnov
authors.affiliation: Multifunctional Optical Materials Group, Institute of Materials Science of Sevilla, Spanish National Research Council-University of Seville, C/Américo Vespucio 49, 41092, Sevilla, Spain.
authors.forename: Mauricio E
authors.initials: ME
authors.lastname: Calvo
authors.affiliation: Multifunctional Optical Materials Group, Institute of Materials Science of Sevilla, Spanish National Research Council-University of Seville, C/Américo Vespucio 49, 41092, Sevilla, Spain.
authors.forename: Hernán
authors.initials: H
authors.lastname: Míguez
authors.affiliation: Synthetic Biology and Smart Therapeutic Systems Group, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), Parque Tecnológico de Andalucía, C/Severo Ochoa 35, 29590, Campanillas, Málaga, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: de la Cueva-Méndez
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D008856:Microscopy, Fluorescence; D016062:Porosity; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays; D015040:Zirconium / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D013473:Sunscreening Agents; D015040:Zirconium; C028541:zirconium oxide
keywords: UV protection; nanoparticles; optical interference filters; photonic crystals; porous multilayers