title: Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls.
abstract: A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.
authors.forename: Marco
authors.initials: M
authors.lastname: Calabrò
authors.affiliation: .Department of Biomedical Science and morphological and functional images, University of Messina, Italy; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
authors.forename: Calabrò
authors.initials: C
authors.lastname: Marco
authors.forename: Antonio
authors.initials: A
authors.lastname: Drago
authors.affiliation: I.R.C.C.S. "San Giovanni di Dio", Fatebenefratelli, Brescia, Italy. Electronic address: antonio.drago76@gmail.com.
authors.forename: Drago
authors.initials: D
authors.lastname: Antonio
authors.forename: Antonina
authors.initials: A
authors.lastname: Sidoti
authors.affiliation: .Department of Biomedical Science and morphological and functional images, University of Messina, Italy; IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
authors.forename: Sidoti
authors.initials: S
authors.lastname: Antonina
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.affiliation: Department of Biomedical and Neuromotor Sciences - DIBINEM -, University of Bologna, Italy.
authors.forename: Serretti
authors.initials: S
authors.lastname: Alessandro
authors.forename: Concetta
authors.initials: C
authors.lastname: Crisafulli
authors.affiliation: .Department of Biomedical Science and morphological and functional images, University of Messina, Italy.
authors.forename: Crisafulli
authors.initials: C
authors.lastname: Concetta
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D053263:Gene Regulatory Networks / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000235:genetics; D038622:Internationality; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*
keywords: Pathway analysis; Pruning; Schizophrenia