title: Neutrophil CD64 expression: a reliable diagnostic marker of infection in advanced cancer patients?
abstract: Infection and sepsis are major health problems in cancer patients. There is a need for the identification and validation of biomarkers to improve their early diagnosis and treatment. Emerging evidence showed that neutrophil CD64 is a highly sensitive and specific marker for systemic infection and sepsis in critically ill patients with various diseases but data on patients bearing solid tumors are still lacking. Using a dedicated flow cytometric assay we evaluated neutrophil CD64 expression in patients with advanced cancer without active infections to verify if it could be utilized as a reliable biomarker of early infections also in oncologic patients.
authors.affiliation: Laboratori di Ricerca Biotecnologie e S.C. Microbiologia e Virologia, Fondazione IRCCS San Matteo, Pavia, Italy.|Medicina Interna e Oncologia Medica, Ospedale di Vigevano, A.o. di Pavia, Italy.
authors.forename: Giuditta
authors.initials: G
authors.lastname: Comolli
authors.affiliation: Epidemiologia Clinica e Biometria, Direzione Scientifica, Fondazione IRCCS San Matteo, Pavia, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Torchio
authors.affiliation: Medicina Interna e Oncologia Medica, Ospedale di Vigevano, A.o. di Pavia, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Lenta
authors.affiliation: Epidemiologia Clinica e Biometria, Direzione Scientifica, Fondazione IRCCS San Matteo, Pavia, Italy.
authors.forename: Benvenuto
authors.initials: B
authors.lastname: Franceschetti
authors.affiliation: Medicina Interna e Oncologia Medica, Ospedale di Vigevano, A.o. di Pavia, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Chiesa
authors.affiliation: Medicina Interna e Oncologia Medica, Ospedale di Vigevano, A.o. di Pavia, Italy.
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Calarota
authors.affiliation: Medicina Interna e Oncologia Medica, Ospedale di Vigevano, A.o. di Pavia, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Baldanti
authors.affiliation: Epidemiologia Clinica e Biometria, Direzione Scientifica, Fondazione IRCCS San Matteo, PAVIA.
authors.forename: Luigia
authors.initials: L
authors.lastname: Scudeller
authors.affiliation: Medicina Interna e Oncologia Medica, Ospedale di Vigevano, A.o. di Pavia, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Marone
authors.affiliation: Epidemiologia Clinica e Biometria, Direzione Scientifica, Fondazione IRCCS San Matteo, Pavia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Danova
authors.forename: Danova
authors.initials: D
authors.lastname: Marco
mesh_terms: D015415:Biomarkers / Q000032:analysis; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D009504:Neutrophils / Q000378:metabolism*; D017452:Receptors, IgG / Q000235:genetics* / Q000378:metabolism; D018805:Sepsis / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D017452:Receptors, IgG
keywords: Cancer patients; Flow cytometry; Infections; Neutrophil CD64; Sepsis