title: Brain glucose sensing in homeostatic and hedonic regulation.
abstract: Glucose homeostasis as well as homeostatic and hedonic control of feeding is regulated by hormonal, neuronal, and nutrient-related cues. Glucose, besides its role as a source of metabolic energy, is an important signal controlling hormone secretion and neuronal activity, hence contributing to whole-body metabolic integration in coordination with feeding control. Brain glucose sensing plays a key, but insufficiently explored, role in these metabolic and behavioral controls, which when deregulated may contribute to the development of obesity and diabetes. The recent introduction of innovative transgenic, pharmacogenetic, and optogenetic techniques allows unprecedented analysis of the complexity of central glucose sensing at the molecular, cellular, and neuronal circuit levels, which will lead to a new understanding of the pathogenesis of metabolic diseases.
authors.affiliation: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Steinbusch
authors.affiliation: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
authors.forename: Gwenaël
authors.initials: G
authors.lastname: Labouèbe
authors.affiliation: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. Electronic address: Bernard.Thorens@unil.ch.
authors.forename: Bernard
authors.initials: B
authors.lastname: Thorens
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D004734:Energy Metabolism; D005518:Food Preferences / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology
chemical_list: D005947:Glucose
keywords: autonomic nervous system; counter-regulation; dopamine; feeding behavior; glucose; glucose sensing