title: PLA2-responsive and SPIO-loaded phospholipid micelles.
abstract: PLA2-responsive and superparamagnetic iron oxide (SPIO) nanoparticle-loaded phospholipid micelles were developed. The release of a phospholipid-conjugated dye from these micelles was triggered due to phospholipid degradation by phospholipase A2. The high relaxivity of the encapsulated SPIO could enable non-invasive magnetic resonance imaging.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. zcheng@seas.upenn.edu.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Gao
authors.forename: Lesan
authors.initials: L
authors.lastname: Yan
authors.forename: Michael
authors.initials: M
authors.lastname: Chiorazzo
authors.forename: E James
authors.initials: EJ
authors.lastname: Delikatny
authors.forename: Andrew
authors.initials: A
authors.lastname: Tsourkas
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008823:Micelles; D054467:Phospholipases A2 / Q000737:chemistry / Q000378:metabolism*; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism
chemical_list: D058185:Magnetite Nanoparticles; D008823:Micelles; D010743:Phospholipids; D054467:Phospholipases A2