title: Formal Asymmetric Hydrobromination of StyrenesviaCopper-Catalyzed 1,3-Halogen Migration.
abstract: An enantioselective Cu(I)-catalyzed 1,3-halogen migration reaction accomplishes a formal hydrobromination by transferring a bromine activating group from a sp2carbon to a benzylic carbon in gooderand with concomitant borylation of the Ar-Br bond. Computational modelling aids in understanding the reaction outcome and suggests future directions to improve the formal asymmetric hydrobromination. The benzyl bromide can be displaced with a variety of nucleophiles to produce a wide array of functionalized products.
authors.affiliation: Department of Chemistry, University of Wisconsin, 1101 University Ave. Madison, Wisconsin 53706, United States.
authors.forename: R J
authors.initials: RJ
authors.lastname: Van Hoveln
authors.affiliation: Department of Chemistry, University of Wisconsin, 1101 University Ave. Madison, Wisconsin 53706, United States.
authors.forename: S C
authors.initials: SC
authors.lastname: Schmid
authors.affiliation: Department of Chemistry, University of Wisconsin, 1101 University Ave. Madison, Wisconsin 53706, United States.
authors.forename: M
authors.initials: M
authors.lastname: Tretbar
authors.affiliation: Department of Chemistry, University of Wisconsin, 1101 University Ave. Madison, Wisconsin 53706, United States.
authors.forename: C T
authors.initials: CT
authors.lastname: Buttke
authors.affiliation: Department of Chemistry, University of Wisconsin, 1101 University Ave. Madison, Wisconsin 53706, United States.
authors.forename: J M
authors.initials: JM
authors.lastname: Schomaker