title: High dose cytarabine, mitoxantrone and l-asparaginase (HAMA) salvage for relapsed or refractory acute myeloid leukemia (AML) in the elderly.
abstract: Acute myeloid leukemia (AML) is an aggressive malignancy that affects older patients. The role of salvage therapy in the elderly is controversial and there is little data on efficacy. Outcomes for 94 relapsed or refractory AML patients who received salvage HAMA therapy were analyzed. Of the 94 patients 66 were ≥60, including 26 patients ≥70, and 28 were <60 years old. Early mortality (30-day) was 14% (4%<60, 18%≥60 years old). Overall, 27% of patients died during hospitalization or were discharged to hospice (11%<60, 33%≥60 years old). CR/CRi was achieved in 41% of patients (61%<60, 33%≥60 years old). Median survival was 6.1 months (15.7<60, 5.2≥60). Patients ≥60 who achieved a CR/CRi had a median survival of 11.7 months. At 12 months 56% of patients <60 were alive versus 24% of patients ≥60. At 24 months these numbers fell to 40% and 2% respectively. In those <60 years old, 50% went on to allogeneic hematopoietic stem cell transplant (HSCT) whereas 14% of patients in the ≥60 cohort did so. In conclusion, HAMA salvage therapy results in a 33% response rate in patients ≥60 years old with acceptable toxicity.
authors.affiliation: Internal Medicine, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Tamjeed
authors.initials: T
authors.lastname: Ahmed
authors.affiliation: Internal Medicine, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Scott
authors.initials: S
authors.lastname: Holwerda
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Heidi D
authors.initials: HD
authors.lastname: Klepin
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Scott
authors.initials: S
authors.lastname: Isom
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Leslie R
authors.initials: LR
authors.lastname: Ellis
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Susan
authors.initials: S
authors.lastname: Lyerly
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Megan
authors.initials: M
authors.lastname: Manuel
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Sarah
authors.initials: S
authors.lastname: Dralle
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Dmitriy
authors.initials: D
authors.lastname: Berenzon
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States.
authors.forename: Bayard L
authors.initials: BL
authors.lastname: Powell
authors.affiliation: Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, United States; Cancer Biology, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC, United States. Electronic address: tspardee@wakehealth.edu.
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Pardee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols; D001215:Asparaginase / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D016019:Survival Analysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D003561:Cytarabine; D008942:Mitoxantrone; D001215:Asparaginase
keywords: Acute myeloid leukemia; Elderly patients; High dose cytarabine; Salvage therapy