title: HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer.
abstract: Cytotoxic T lymphocytes (CTLs) recognize the human leukocyte antigen (HLA) class I and antigenic peptide complex, and they play a crucial role in cancer immunity. Our recent study revealed that HLA class I downregulation is related to poorer prognosis and a low level of intratumoral CTLs is associated with platinum resistance, indicating the significance of immunological surveillance.
authors.affiliation: Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hirohashi
authors.affiliation: Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Torigoe
authors.affiliation: Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan ; Department of Obstetrics and Gynecology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Mariya
authors.affiliation: Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
authors.forename: Vitaly
authors.initials: V
authors.lastname: Kochin
authors.affiliation: Department of Obstetrics and Gynecology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saito
authors.affiliation: Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sato
keywords: CTL; CTL, cytotoxic T lymphocyte; HLA class I; HLA, human leukocyte antigen; MHC, major histocompatibility complex; TAA, tumor-associated antigen; ovarian cancer; platinum resistance