title: The association of autoimmune diseases with pediatric ulcerative colitis does not influence its disease course.
abstract: OBJECTIVE
  Ulcerative colitis (UC) is a chronic inflammatory condition. Previous reports suggested that UC may have a worse prognosis when associated with auto-immune diseases. We compared characteristics at diagnosis and natural history of the disease between classical ulcerative colitis (CUC) and UC associated with auto-immune diseases (CAI) in children.
  
  
  METHODS
  In this study, 67 children followed for UC at Nancy University Hospital between 1993 and 2012 were included: 45 patients in the CUC group and 22 in the CAI group.
  
  
  RESULTS
  Median follow-up was 4.8 years. Median age at diagnosis was 11.6 years in the CAI group and 9.8 years in the CUC group. Time between symptoms onset and diagnosis was broadly similar in the two groups (<3 months) and there were no significant differences regarding biological and histological findings. At 5 years, the need for corticosteroids and azathioprine did not differ between the CAI and the CUC groups. There was also no significant difference between the two groups regarding infliximab use at 1 and 5 years.
  
  
  CONCLUSIONS
  In this pediatric study, CAI had similar characteristics at baseline as CUC. The course of CAI does not seem to be influenced by the presence of concomitant auto-immune diseases.
authors.affiliation: a 1 Unité d'Hépato Gastro-Entérologie et Nutrition Pédiatriques, Service de Médecine Infantile et Génétique Clinique, Hôpital d'Enfants, CHU Nancy Brabois, Inserm U954, Université de Lorraine , rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Guinet-Charpentier
authors.affiliation: b 2 Service d'Anatomopathologie, CHU Nancy Brabois , rue du Morvan, 54511 Vandoeuvre-lès-Nancy, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Champigneulle
authors.affiliation: c 3 Service d'Hépato-Gastro-Entérologie, CHU Nancy Brabois, Inserm U954, Université de Lorraine , rue du Morvan, 54511 Vandoeuvre-lès-Nancy, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Williet
authors.affiliation: c 3 Service d'Hépato-Gastro-Entérologie, CHU Nancy Brabois, Inserm U954, Université de Lorraine , rue du Morvan, 54511 Vandoeuvre-lès-Nancy, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
authors.affiliation: a 1 Unité d'Hépato Gastro-Entérologie et Nutrition Pédiatriques, Service de Médecine Infantile et Génétique Clinique, Hôpital d'Enfants, CHU Nancy Brabois, Inserm U954, Université de Lorraine , rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Morali
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D018450:Disease Progression; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D000069285:Infliximab / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D000069285:Infliximab; D001379:Azathioprine
keywords: auto-immunity; children; pediatric inflammatory bowel disease; ulcerative colitis