title: Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics.
abstract: OBJECTIVE
  Matrix metalloproteinase-9 (MMP-9) index is the ratio of active MMP-9 and total MMP-9 levels. It reflects the importance of MMP-9 in acute coronary syndrome (ACS).
  
  
  METHODS
  The study included 3 groups of patients (n = 87): the group 1 - non-diabetic subjects without ACS (control); the group 2 - diabetic patients with ACS [subgroups with unstable angina pectoris (UAP), myocardial infarction (MI) or reinfarction]; and the group 3 non-diabetics patients with ACS. Total and active MMP-9 were measured and used to create MIP-9 index.
  
  
  RESULTS
  MMP-9 index, as a marker showed good sensitivity and specificity, of ACS in diabetics, with a cut-off value over 58.2. MMP-9 was higher in the study groups than in the control one. MMP-9 correlated with ACS occurrence and type of cardiovascular event. A statistically significant difference was found among the groups according to active MMP-9 (p < 0.001). The same was found with active MMP-9 between the control and the group with MI (p < 0.001). The control was highly statistically significantly different from the group of patients with UAP (p < 0.01). Statically significant differences in MMP-9 index was found between the control and the diabetics with ACS (P < 0.001). Statistically significant difference of MMP-9 index was also found in the controls compared to the value in non-diabetic patients with ACS (p < 0.01).
  
  
  CONCLUSIONS
  MMP-9 index may be a possible marker of atheromatous plaque rupture in diabetics.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Popović
authors.forename: Fadil
authors.initials: F
authors.lastname: Canović
authors.forename: Miroljub
authors.initials: M
authors.lastname: Ilić
authors.forename: Sašo
authors.initials: S
authors.lastname: Rafajlovski
authors.forename: Vesna
authors.initials: V
authors.lastname: Dimitrijević-Srećović
authors.forename: Dragana
authors.initials: D
authors.lastname: Matanović
authors.forename: Svetlana
authors.initials: S
authors.lastname: Vujović
authors.forename: Predrag
authors.initials: P
authors.lastname: Djordjević
authors.forename: Draško
authors.initials: D
authors.lastname: Gostiljac
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D058226:Plaque, Atherosclerotic
chemical_list: D015415:Biomarkers; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9