title: Clinical utility of RASSF1A methylation in human malignancies.
abstract: The high frequency of RASSF1A methylation has been noted in a vast number of patients in a broad spectrum of malignancies, suggesting that RASSF1A inactivation is associated with cancer pathogenesis. However, whether this recurrent incidence of RASSF1A hypermethylation in human malignancies and its association with more aggressive tumour phenotype is a frequent event across different cancer types has not yet been discussed. In this review, we interrogated existing evidence for association of RASSF1A hypermethylation with clinicopathological characteristics that can indicate more invasive lesions.
authors.affiliation: CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford, Oxford, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Grawenda
authors.affiliation: CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford, Oxford, UK.
authors.forename: E
authors.initials: E
authors.lastname: O'Neill
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D019175:DNA Methylation; D020868:Gene Silencing; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C411762:RASSF1 protein, human; D025521:Tumor Suppressor Proteins