title: Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum.
abstract: Infection with Schistosoma japonicum causes high levels of pathology that is predominantly determined by the cellular and humoral response of the host. However, the specific antibody response that arises during the development of disease is largely undescribed in Asian schistosomiasis-endemic populations. A schistosome protein microarray was used to compare the antibody profiles of subjects with acute infection, with early or advanced disease associated with severe pathology, with chronic infection, and subjects exposed but stool negative for S. japonicum eggs to the antibody profiles of nonexposed controls. Twenty-five immunodominant antigens were identified, including vaccine candidates, tetraspanin-related proteins, transporter molecules, and unannotated proteins. Additionally, individuals with severe pathology had a limited specific antibody response, suggesting that individuals with mild disease may use a broad and strong antibody response, particularly against surface-exposed proteins, to control pathology and/or infection. Our study has identified specific antigens that can discriminate between S. japonicum-exposed groups with different pathologies and may also allow the host to control disease pathology and provide resistance to parasite infection.
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane.
authors.forename: Patrick
authors.initials: P
authors.lastname: Driguez
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane Hunan Institute of Parasitic Diseases, Yueyang, China.
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns Centro de Pesquisas René Rachou, Oswaldo Cruz Foundation, Minas Gerais, Brazil.
authors.forename: Soraya
authors.initials: S
authors.lastname: Gaze
authors.affiliation: Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Pearson
authors.affiliation: University of California-Irvine.
authors.forename: Rie
authors.initials: R
authors.lastname: Nakajima
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane.
authors.forename: Angela
authors.initials: A
authors.lastname: Trieu
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane.
authors.forename: Denise L
authors.initials: DL
authors.lastname: Doolan
authors.affiliation: University of California-Irvine.
authors.forename: Philip L
authors.initials: PL
authors.lastname: Felgner
authors.affiliation: Hunan Institute of Parasitic Diseases, Yueyang, China.
authors.forename: Xunya
authors.initials: X
authors.lastname: Hou
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane Institute for Molecular Biosciences, University of Queensland, St. Lucia, Australia.
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Cardoso
authors.affiliation: University of California-Irvine.
authors.forename: Algis
authors.initials: A
authors.lastname: Jasinskas
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane.
authors.forename: Geoffrey N
authors.initials: GN
authors.lastname: Gobert
authors.affiliation: Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns.
authors.forename: Alex
authors.initials: A
authors.lastname: Loukas
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane.
authors.forename: Donald P
authors.initials: DP
authors.lastname: McManus
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood / Q000145:classification / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology*; D016000:Cluster Analysis; D015331:Cohort Studies; D015801:Helminth Proteins / Q000276:immunology; D006801:Humans; D040081:Protein Array Analysis; D012549:Schistosoma japonicum / Q000276:immunology*; D012552:Schistosomiasis / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015801:Helminth Proteins
keywords: Schistosoma japonicum; antibody; human disease; immunology; protein microarray; schistosomiasis