title: Restoration of defective cross-presentation in tumors by gemcitabine.
abstract: Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8+T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites.
authors.affiliation: School of Medicine and Pharmacology; The University of Western Australia ; Nedlands, WA, Australia ; National Centre for Asbestos Related Diseases ; Nedlands, WA, Australia.
authors.forename: Alison M
authors.initials: AM
authors.lastname: McDonnell
authors.affiliation: School of Medicine and Pharmacology; The University of Western Australia ; Nedlands, WA, Australia ; National Centre for Asbestos Related Diseases ; Nedlands, WA, Australia.
authors.forename: W
authors.initials: W
authors.lastname: Joost Lesterhuis
authors.affiliation: School of Medicine and Pharmacology; The University of Western Australia ; Nedlands, WA, Australia ; National Centre for Asbestos Related Diseases ; Nedlands, WA, Australia.
authors.forename: Andrea
authors.initials: A
authors.lastname: Khong
authors.affiliation: School of Medicine and Pharmacology; The University of Western Australia ; Nedlands, WA, Australia ; National Centre for Asbestos Related Diseases ; Nedlands, WA, Australia ; Department of Medical Oncology; Sir Charles Gairdner Hospital ; Nedlands, WA, Australia.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Nowak
authors.affiliation: School of Medicine and Pharmacology; The University of Western Australia ; Nedlands, WA, Australia ; National Centre for Asbestos Related Diseases ; Nedlands, WA, Australia.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lake
authors.affiliation: School of Medicine and Pharmacology; The University of Western Australia ; Nedlands, WA, Australia ; School of Veterinary and Life Sciences, Murdoch University , Murdoch, WA, Australia.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Currie
authors.affiliation: School of Medicine and Pharmacology; The University of Western Australia ; Nedlands, WA, Australia ; National Centre for Asbestos Related Diseases ; Nedlands, WA, Australia.
authors.forename: Bruce Ws
authors.initials: BW
authors.lastname: Robinson
keywords:  chemotherapy; cross-presentation; gemcitabine; tumor-infiltrating dendritic cells