title: Assessment of Long-Term Outcomes in Hbs Ag-Negative Renal Transplant Recipients Transplanted from Hbs Ag-Positive Donors.
abstract: BACKGROUND
  The aim of this study was to evaluate the long-term outcomes of renal transplantation from Hbs Ag-positive donors to Hbs Ag-negative recipients.
  
  
  METHODS
  A total of 78 patients who underwent renal transplantation in our clinic between January 2006 and May 2014 were included in the study. Patients were divided into 2 groups: Group 1: Donor Hbs Ag (+) (n=26, Hbs Ab (-), Hbe Ag (-), Hbe Ab (+), Hbc Ig total (+) and HBV DNA (+), male/female (M/F): 16 (61.5%)/10 (38.5%), and Group 2: Donor Hbs Ag (-) (n=52, M/F: 41 (78.8%)/11 (21.2%). Hbs Ab levels were similar in recipients in both groups. Data were collected retrospectively. Analyses were performed by using SPSS 20.0 software, and patient and graft survival were measured by using Kaplan-Meier survival curve and compared by using the log-rank test.
  
  
  RESULTS
  Demographic data were similar in the 2 groups. The rate of acute Hepatitis B infection was significantly higher in Group 1 than in Group 2 [n=3 (11.5%) vs. n=0 (0%), respectively, p=0.012]. Acute hepatitis B attacks were detected in vaccinated patients. Graft survival rates (groups 1 and 2, respectively; at 1st, 3rd, 5th and 8th years: 95% vs. 96%, 95% vs. 94%, 85% vs. 88%, 85% vs. 82%, p=0.970) and patient survival rates (p=0.098), acute rejection rates (p=0.725), delayed graft function, chronic allograft dysfunction, new-onset diabetes after transplantation (NODAT), cytomegalovirus infection, and the need for postoperative dialysis and plasmapheresis were similar between groups.
  
  
  CONCLUSIONS
  Our study revealed that the risk of developing acute hepatitis B was higher in patients renally transplanted from Hbs Ag (+) donors, but the other clinical outcomes were similar between groups.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: Vural Taner
authors.initials: VT
authors.lastname: Yilmaz
authors.affiliation: Department of General Surgery, Dicle University Medical School, Diyarbakır, Turkey.
authors.forename: Burak Veli
authors.initials: BV
authors.lastname: Ulger
authors.affiliation: Department of General Surgery, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Aliosmanoglu
authors.affiliation: Department of General Surgery, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Erbis
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: Yasar
authors.initials: Y
authors.lastname: Tuna
authors.affiliation: Department of Biochemistry, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: Halide
authors.initials: H
authors.lastname: Akbas
authors.affiliation: Department of Biochemistry, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: Sebahat
authors.initials: S
authors.lastname: Ozdem
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Cetinkaya
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: Gultekin
authors.initials: G
authors.lastname: Suleymanlar
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Kocak
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D006509:Hepatitis B / Q000453:epidemiology; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D014019:Tissue Donors; D066027:Transplant Recipients; D016896:Treatment Outcome
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens