title: Hormonal and psychosocial correlates of psychological well-being and negative affectivity in young gynecological-endocrinological patients.
abstract: To study the relationship between hormones, psychosocial factors and psychological well-being or negative affectivity (NA), 102 women (aged 15-31) responded to the 12-item well-being questionnaire (W-BQ12), with subscales for positive well-being (PWB), negative well-being (NWB) and energy (ENE); the Hospital Anxiety and Depression Scale (HADS), consisting of depression (HADS-D) and anxiety (HADS-A) subscales; the Beck Depression Inventory (BDI), and the Hamilton Depression Scale (HAMD). The univariate analysis revealed significant negative correlations between luteinizing hormone (LH) and HADS-T, HADS-D and HADS-A, and between follicle stimulating hormone (FSH) and HADS-A. Positive correlations were shown for thyroid stimulating hormone (TSH), HADS-T, and HADS-A. Cortisol and prolactin levels strongly correlated with BDI and HAMD scores, respectively. In a multivariate analysis, TSH significantly predicted the mood impairment in HADS-T (β = 0.68) and HADS-A (β = 0.68), while economic status predicted the general well-being (β = 0.75), NWB (β = -0.83), ENE (β = 0.89), and HADS-A (β = -0.63). We could not detect any significant differences in NA or well-being in patients with versus without PCOS or with versus without hirsutism, but almost all psychometric parameters differed significantly according to the economic status. In conclusion, TSH was the only hormonal predictor of overall NA and anxiety, and low-economic status overtrumped the impact of hormones on the psychological well-being.
authors.affiliation: a Department of Gynecology and Obstetrics , St. Josefskrankenhaus, Teaching Hospital of the University of Freiburg , Freiburg , Germany .
authors.forename: Rafal
authors.initials: R
authors.lastname: Watrowski
authors.affiliation: b Department of Psychosomatics in Gynecology , Women's University Hospital Bonn , Bonn , Germany , and.
authors.forename: Anke
authors.initials: A
authors.lastname: Rohde
authors.affiliation: c Department of Gynecological Endocrinology , Poznan University of Medical Sciences , Poznan , Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Maciejewska-Jeske
authors.affiliation: c Department of Gynecological Endocrinology , Poznan University of Medical Sciences , Poznan , Poland.
authors.forename: Blazej
authors.initials: B
authors.lastname: Meczekalski
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect; D001007:Anxiety / Q000378:metabolism / Q000523:psychology*; D003863:Depression / Q000378:metabolism / Q000523:psychology*; D004704:Endocrinology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006176:Gynecology; D006628:Hirsutism / Q000209:etiology / Q000378:metabolism / Q000523:psychology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008603:Mental Health; D015999:Multivariate Analysis; D009839:Oligomenorrhea / Q000209:etiology / Q000378:metabolism / Q000523:psychology; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism / Q000523:psychology*; D011388:Prolactin / Q000378:metabolism; D011594:Psychometrics; D012923:Social Class; D011795:Surveys and Questionnaires; D013972:Thyrotropin / Q000378:metabolism; D055815:Young Adult
chemical_list: D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D006854:Hydrocortisone
keywords: Anxiety; TSH; depression; economic status; hormones; psychological well-being