title: Nanocarrier for Oral Peptide Delivery Produced by Polyelectrolyte Complexation in Nanoconfinement.
abstract: The hydrophilic peptide YY (PYY) is a promising hormone-based antiobesity drug. We present a new concept for the delivery of PYY from pH-responsive chitosan-based nanocarriers. To overcome the drawbacks while retaining the merits of the polyelectrolyte complex (PEC) method, we propose a one-pot approach for the encapsulation of a hydrophilic peptide drug in cross-linked PEC nanocarriers. First, the hydrophilic peptide is encapsulated via polyelectrolyte complexation within water-in-oil miniemulsion droplets. In a second step, the PEC surface is reinforced by controlled interfacial cross-linking. PYY is efficiently encapsulated and released upon pH change. Such nanocarriers are promising candidates for the fight against obesity and, in general, for the oral delivery of protein drugs.
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Parowatkin
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Mailänder
authors.affiliation: ‡University of Ulm, Institute of Micro- and Nanomaterials, Albert-Einstein-Allee 47, D-89081, Ulm, Germany.
authors.forename: Marion
authors.initials: M
authors.lastname: Flechtner-Mors
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Graf
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Best
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Kaloian
authors.initials: K
authors.lastname: Koynov
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Kristin
authors.initials: K
authors.lastname: Mohr
authors.affiliation: §University of Ulm, Institute of Organic Chemistry III, Albert-Einstein-Allee 11, D-89081, Ulm, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Ziener
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Landfester
authors.affiliation: †Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Crespy
mesh_terms: D000464:Alginates / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers; D004573:Electrolytes / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009765:Obesity / Q000188:drug therapy*; D019894:Peptide YY / Q000737:chemistry* / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000464:Alginates; D004337:Drug Carriers; D004573:Electrolytes; D006603:Hexuronic Acids; D011108:Polymers; D019894:Peptide YY; D048271:Chitosan