title: Plasmakinetic resection technology for the treatment of benign prostatic hyperplasia: evidence from a systematic review and meta-analysis.
abstract: The aim of this study was to compare plasmakinetic resection of the prostate (PKRP) with transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH) in terms of efficacy and safety. Published RCTs were searched from PubMed, Embase, Science Citation Index, and Cochrane Library up to April 10, 2014. After methodological quality assessment and data extraction, meta-analysis was performed using the STATA 12.0 software. 18 reports of 16 RCTs were included in this analysis. Meta-analyses showed that PKRP significantly improved Qmax at 12 months, but no significant difference was found for other efficacy outcomes. In terms of safety, treatment of PKRP was associated with reduced drop in serum sodium, lower TUR syndrome, reduced need of blood transfusion, clot retention, and shorter catheterization time and hospital stay; in contrast, there were no significant differences in the analysis of operative time, postoperative fever, and long-term postoperative complications. In summary, current evidence suggests that, although PKRP and TURP are both effective for BPH, PKRP is associated with additional potential benefits in efficacy and more favorable safety profile. It may be possible that PKRP may replace the TURP in the future and become a new standard surgical procedure.
authors.affiliation: 1] Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China [2] Center for Evidence-based and Translational Medicine, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.affiliation: Chinese Evidence-Based Center and Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
authors.forename: Joey S W
authors.initials: JS
authors.lastname: Kwong
authors.affiliation: 1] Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China [2] Center for Evidence-based and Translational Medicine, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zeng
authors.affiliation: Department of Hematology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Ruan
authors.affiliation: Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Tong-Zu
authors.initials: TZ
authors.lastname: Liu
authors.affiliation: Center for Evidence-based and Translational Medicine, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Weng
authors.affiliation: Department of Epidemiology, School of Public Health, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Chang
authors.initials: C
authors.lastname: Xu
authors.affiliation: Center for Evidence-based and Translational Medicine, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Jin-Zhu
authors.initials: JZ
authors.lastname: Yan
authors.affiliation: Center for Evidence-based and Translational Medicine, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Meng
authors.affiliation: 1] Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China [2] Center for Evidence-based and Translational Medicine, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Xing-Huan
authors.initials: XH
authors.lastname: Wang
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D011468:Prostatectomy / Q000009:adverse effects / Q000379:methods*; D011470:Prostatic Hyperplasia / Q000601:surgery*; D017594:Publication Bias; D011788:Quality of Life; D020728:Transurethral Resection of Prostate; D016896:Treatment Outcome