title: MMPs and ADAMTSs in intervertebral disc degeneration.
abstract: Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with low back pain, a leading cause of musculoskeletal disability worldwide. The major components of extracellular matrix (ECM) within the discs are type II collagen (Col II) and aggrecan. Excessive destruction of ECM, especially loss of Col II and aggrecan, plays a critical role in promoting the occurrence and development of IDD. Matrix metalloproteinases (MMPs) and a disintegrin and metalloprotease with thrombospondin motifs (ADAMTSs) are primary enzymes that degrade collagens and aggrecan. There is a large and growing body of evidence that many members of MMPs and ADAMTSs are highly expressed in degenerative IVD tissue and cells, and are closely involved in ECM breakdown and the process of disc degeneration. In contrast, targeting these enzymes has shown promise for promoting ECM repair and mitigating disc regeneration. In the current review, after a brief description regarding the biology of MMPs and ADAMTSs, we mainly focus on their expression profiles, roles and therapeutic potential in IDD. A greater understanding of the catabolic pathways involved in IDD will help to develop potential prophylactic or regenerative biological treatment for degenerative disc disease in the future.
authors.affiliation: Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China. Electronic address: wwwwjj167@qq.com.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Wang
authors.affiliation: Life Science Research Center, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Yu
authors.affiliation: Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Wen-Si
authors.initials: WS
authors.lastname: He
authors.affiliation: Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Shu-Jun
authors.initials: SJ
authors.lastname: Zhang
authors.affiliation: Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Yi-Guo
authors.initials: YG
authors.lastname: Yan
authors.affiliation: Department of Hand and Micro-surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D051722:ADAM Proteins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000188:drug therapy / Q000378:metabolism*; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D051722:ADAM Proteins; D020782:Matrix Metalloproteinases
keywords: ADAMTSs; Aggrecan; Col II; IDD; MMPs