title: Fibrinogen, red blood cells, and factor XIII in venous thrombosis.
abstract: Cardiovascular disease is the leading cause of death and disability worldwide. Among cardiovascular causes of death, venous thrombosis (VT) is ranked third most common in the world. Venous thrombi have high red blood cell and fibrin content; however, the pathophysiologic mechanisms that contribute to venous thrombus composition and stability are still poorly understood. This article reviews biological, biochemical, and biophysical contributions of fibrinogen, factor XIII, and red blood cells to VT, and new evidence suggesting interactions between these components mediate venous thrombus composition and size.
authors.affiliation: Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: B L
authors.initials: BL
authors.lastname: Walton
authors.affiliation: Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Byrnes
authors.affiliation: Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Wolberg
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D004912:Erythrocytes / Q000378:metabolism*; D005176:Factor XIII / Q000737:chemistry / Q000378:metabolism*; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D011487:Protein Conformation; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D020246:Venous Thrombosis / Q000097:blood* / Q000503:physiopathology
chemical_list: D005337:Fibrin; D005340:Fibrinogen; D005176:Factor XIII
keywords: clot retraction; factor XIII; fibrinogen; platelet; red blood cell; venous thrombosis