title: Pre-training Catechin gavage prevents memory impairment induced by intracerebroventricular streptozotocin in rats.
abstract: OBJECTIVE
  To evaluate the effects of Catechin (CAT) on memory acquisition and retrieval in the animal model of sporadic alzheimer`s disease (sAD) induced by intracerebroventricular (icv) injection of streptozotocin (STZ) in passive avoidance memory test.
  
  
  METHODS
  Thirty adult rats were divided into 5 experimental groups (n=6). Animals were treated by icv saline/STZ (3 mg/kg) injection at day one and 3 after cannulation. The STZ+CAT group received 40 mg/kg CAT by daily gavages for 10 days, after icv STZ treatment and before training. The step-through latency (STL) and time spent in the dark compartment (TDC) were evaluated to examine the memory acquisition and retrieval. All tests were performed in Qom University of Medical Sciences, Qom, Iran, from April to December 2013.
  
  
  RESULTS
  The STZ treatment significantly decreased STL and increased the number of entries to the dark compartment on the training day. It also increased TDC, on day one and 7 after training. Pre-training gavage of CAT reversed the STL significantly (p=0.027). The CAT treatment also decreased the TDC in both early and late retrieval, in respect to STZ group.
  
  
  CONCLUSIONS
  This data suggests that CAT as an antioxidant could improve both memory acquisition and retrieval in the animal model of sAD.
authors.affiliation: Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Zamani
authors.forename: Kambiz
authors.initials: K
authors.lastname: Rohampour
authors.forename: Maryam
authors.initials: M
authors.lastname: Zeraati
authors.forename: Narges
authors.initials: N
authors.lastname: Hosseinmardi
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Kazemian
mesh_terms: D000284:Administration, Oral; D000544:Alzheimer Disease / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002392:Catechin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000633:toxicity
chemical_list: D013311:Streptozocin; D002392:Catechin