title: Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion.
abstract: Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, dietary feeding with Cynara scolymus leaf extract reduces the growth of mesothelioma xenografted tumors similarly to pemetrexed, a commonly employed drug in the treatment of mesothelioma. In aggregate our findings suggest that leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma.
authors.affiliation: Molecular Chemoprevention Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Pulito
authors.affiliation: Molecular Chemoprevention Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Mori
authors.affiliation: Translational Oncogenomic Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sacconi
authors.affiliation: Department of Chemistry, University of Rome "La Sapienza", Rome, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Casadei
authors.affiliation: Translational Oncogenomic Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Ferraiuolo
authors.affiliation: Department of Chemistry, University of Rome "La Sapienza", Rome, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Valerio
authors.affiliation: Molecular Chemoprevention Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Raffaela
authors.initials: R
authors.lastname: Santoro
authors.affiliation: Translational Oncogenomic Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Frauke
authors.initials: F
authors.lastname: Goeman
authors.affiliation: Aboca SpA Società Agricola, Sansepolcro, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Maidecchi
authors.affiliation: Aboca SpA Società Agricola, Sansepolcro, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Mattoli
authors.affiliation: Department of Chemistry, University of Rome "La Sapienza", Rome, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Manetti
authors.affiliation: Translational Oncogenomic Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Di Agostino
authors.affiliation: Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Paola
authors.initials: P
authors.lastname: Muti
authors.affiliation: Translational Oncogenomic Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.|Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Blandino
authors.affiliation: Molecular Chemoprevention Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.|Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Strano
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D031943:Cynara scolymus / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008654:Mesothelioma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000086002:Mesothelioma, Malignant; D051379:Mice; D009361:Neoplasm Invasiveness; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D013997:Time Factors; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: apoptosis; invasion; mesothelioma; pathway; tumorigenicity