title: Multi-Target Cytotoxic Actions of Flavonoids in Blood Cancer Cells.
abstract: To date, cytotoxic effects of flavonoids in various cancer cells are well accepted. However, the intracellular signaling cascades triggered by these natural compounds remain largely unknown and elusive. In this mini- review, the multiplicity of molecular targets of flavonoids in blood cancer cells is discussed by demonstrating the involvement of various signaling pathways in induction of apoptotic responses. Although these data reveal a great potential of flavonoids for the development of novel agents against different types of hematological malignancies, the pleiotropic nature of these compounds in modulation of cellular processes and their interactions certainly need unraveling and further investigation.
authors.affiliation: Department of Hematology and Oncology, University of Tartu, Tartu, Estonia E-mail : katrin.sak.001@mail.ee.
authors.forename: Katrin
authors.initials: K
authors.lastname: Sak
authors.forename: Hele
authors.initials: H
authors.lastname: Everaus
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D005419:Flavonoids