title: The Toll/NF-κB pathway in cuttlefish symbiotic accessory nidamental gland.
abstract: The female genital apparatus of decapod cephalopods contains a symbiotic accessory nidamental gland (ANG) that harbors bacterial symbionts. Although the ANG bacterial consortium is now well described, the impact of symbiosis on Sepia officinalis innate immunity pathways remains unknown. In silico analysis of the de novo transcriptome of ANG highlighted for the first time the existence of the NF-κB pathway in S. officinalis. Several signaling components were identified, i.e. five Toll-like receptors, eight signaling cascade features, and the immune response target gene iNOS, previously described as being involved in the initiation of bacterial symbiosis in a cephalopod gland. This work provides a first key for studying bacterial symbiosis and its impact on innate immunity in S. officinalis ANG.
authors.affiliation: Université de Caen Basse-Normandie, F-14032 Caen, France; UMR 7208 BOREA CNRS INEE, F-14032 Caen, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Cornet
authors.affiliation: Université de Caen Basse-Normandie, F-14032 Caen, France; UMR 7208 BOREA CNRS INEE, F-14032 Caen, France; Plateforme Post-génomique PROTEOGEN, F-14032 Caen, France.
authors.forename: Joël
authors.initials: J
authors.lastname: Henry
authors.affiliation: Plateforme ABiMS, Station biologique de Roscoff (UPMC-CNRS), F-29688 Roscoff, France.
authors.forename: Erwan
authors.initials: E
authors.lastname: Corre
authors.affiliation: Plateforme ABiMS, Station biologique de Roscoff (UPMC-CNRS), F-29688 Roscoff, France.
authors.forename: Gildas
authors.initials: G
authors.lastname: Le Corguillé
authors.affiliation: Université de Caen Basse-Normandie, F-14032 Caen, France; UMR 7208 BOREA CNRS INEE, F-14032 Caen, France. Electronic address: celine.gaudin@unicaen.fr.
authors.forename: Céline
authors.initials: C
authors.lastname: Zatylny-Gaudin
mesh_terms: D000818:Animals; D005835:Genitalia / Q000378:metabolism*; D007113:Immunity, Innate / Q000276:immunology*; D064307:Microbiota / Q000276:immunology; D016328:NF-kappa B / Q000235:genetics* / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000235:genetics; D049833:Sepia / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D013559:Symbiosis; D051193:Toll-Like Receptors / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome / Q000235:genetics
chemical_list: D016328:NF-kappa B; D051193:Toll-Like Receptors; D052247:Nitric Oxide Synthase Type II
keywords: Cephalopod; Genital glands; Innate immunity; Invertebrate; NF-kappaB pathway; Symbiosis; Toll-like receptor