title: Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron.
abstract: The electrogenic Na(+)-HCO3 (-) cotransporter 2 (NBCe2) is a newly discovered protein in the distal nephron. Our understanding is minimal regarding its physiological role in renal electrolyte transport. In this mini-review, we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron.
authors.affiliation: Department of Cellular/Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska donghai.wen@phhs.org.
authors.forename: Donghai
authors.initials: D
authors.lastname: Wen
authors.affiliation: Department of Cellular/Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Sansom
mesh_terms: D000818:Animals; D001692:Biological Transport; D004573:Electrolytes / Q000378:metabolism*; D006801:Humans; D006977:Hypertension, Renal / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D009399:Nephrons / Q000378:metabolism*; D027982:Sodium-Bicarbonate Symporters / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D004573:Electrolytes; D027982:Sodium-Bicarbonate Symporters
keywords: Ca2+; K+; NBCe2; acid-base; hypertension