title: Association of MnSOD AA Genotype with the Progression of Prostate Cancer.
abstract: OBJECTIVE
  To investigate whether manganese superoxide dismutase (MnSOD) genetic polymorphism is associated with the clinical significance of prostate cancer.
  
  
  METHODS
  Prostates were obtained from 194 deceased men 45 years or older who did not have a history of prostate cancer. Serial sections and histological examinations of the prostate were performed. The MnSOD genotypes of the specimens were determined by polymerase chain reaction restriction fragment length polymorphism analysis.
  
  
  RESULTS
  Of the 194 men, 31 and 26 had clinically insignificant and significant prostate cancer. Clinically significant cancer comprised 29% and 58% of the cancers in men <70 and >70 years old, respectively. The age-specific proportion of significant cancer significantly increased with the advance of age (p<0.001). MnSOD AA, as compared with the other genotypes (VA and VV together), was associated with significant prostate cancer across all ages, odds ratio (OR) 2.34, 95% confidence interval (CI) 0.99-5.49, and in men older than 69 years (OR 4.89, 95% CI 1.51-15.8), but not in men younger than 70 years. The genotype was not associated with clinically insignificant cancer regardless of age. The comparison between significant and insignificant cancer, the OR (95% CI) for MnSOD AA was 5.04 (1.05-24.2) (sensitivity 0.57, specificity 0.78, positive predictive value 0.78) in men older than 69 years.
  
  
  CONCLUSIONS
  MnSOD polymorphism is strongly associated with the clinical significance of prostate cancer in men older than 69 years, but not in men younger than 70 years suggesting that oxidative stress may be involved in the progression of the disease. MnSOD may be a clinically useful marker to predict the potential of progression of prostate cancer.
authors.affiliation: Department of Urology, SUNY Upstate Medical University, Syracuse, New York, United States of America; Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Iguchi
authors.affiliation: Department of Urology, SUNY Upstate Medical University, Syracuse, New York, United States of America.
authors.forename: Ching Y
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Department of Urology, SUNY Upstate Medical University, Syracuse, New York, United States of America; Department of Urology, Cochin Hospital, Paris, France.
authors.forename: Nicolas B
authors.initials: NB
authors.lastname: Delongchamps
authors.affiliation: Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Kato
authors.affiliation: Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tamada
authors.affiliation: Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamasaki
authors.affiliation: Department of Pathology, SUNY Upstate Medical University, Syracuse, New York, United States of America.
authors.forename: Gustavo
authors.initials: G
authors.lastname: de la Roza
authors.affiliation: Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
authors.affiliation: Department of Urology, SUNY Upstate Medical University, Syracuse, New York, United States of America.
authors.forename: Gabriel P
authors.initials: GP
authors.lastname: Haas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018450:Disease Progression; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D013482:Superoxide Dismutase