title: STAT3in arsenic lung carcinogenicity.
abstract: We recently found that the chronic sterile inflammation contributes to arsenic lung tumorigenesis which is inhibited by autophagy.STAT3regulates the interaction between inflammation and autophagy.STAT3may also play a critical role in mediating the crosstalk between lung epithelial cells and their microenvironment, including immune cells, during arsenic lung carcinogenesis.
authors.affiliation: Department of Pharmacology & Nutritional Sciences; University of Kentucky College of Medicine ; Lexington, KY, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
keywords: STAT3; arsenic; autophagy; immunosurveillance; lung tumorigenesis; microenvironment