title: Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
abstract: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder related to inflammation. Coenzyme Q10 (CoQ10) is a natural compound that has recently been considered as an anti-inflammatory factor. In the current study we aimed to evaluate the effects of CoQ10 supplementation on liver enzymes, inflammation status, and adipokines in patients with NAFLD.
  
  
  
  Forty-one subjects with NAFLD participated in the current randomized, double-blind, placebo-controlled trial. The participants were randomly divided into 2 groups: one group received CoQ10 capsules (100 mg once a day) and the other received placebo for 12 weeks. Blood samples of each patient were taken before and after the 12-week intervention period for measurement of liver aminotransferases, inflammatory biomarkers, and adipokines (adiponectin and leptin).
  
  
  
  Taking 100 mg CoQ10 supplement daily resulted in a significant decrease in liver aminotransferases (aspartate aminotransferase [AST] and gamma-glutamyl transpeptidase [GGT]), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor α, and the grades of NAFLD in the CoQ10 group in comparison to the control group (p < 0.05). In addition, patients who received CoQ10 supplement had higher serum levels of adiponectin (p = 0.016) and considerable changes in serum leptin (p = 0.053). However, no significant changes occurred in serum levels of interleukin-6 in both groups.
  
  
  
  The present study suggested that CoQ10 supplement at a dosage of 100 mg could be effective for improving the systemic inflammation and biochemical variables in NAFLD.
authors.affiliation: a Department of Nutrition, Nutrition and Metabolic Disease Research Center, Faculty of Paramedicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
authors.forename: Farnaz
authors.initials: F
authors.lastname: Farsi
authors.affiliation: a Department of Nutrition, Nutrition and Metabolic Disease Research Center, Faculty of Paramedicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
authors.forename: Majid
authors.initials: M
authors.lastname: Mohammadshahi
authors.affiliation: b Department of Institute for Infectious Diseases of the Digestive System, Faculty of Medicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
authors.forename: Pezhman
authors.initials: P
authors.lastname: Alavinejad
authors.affiliation: c Department of Radiology, Faculty of Medicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
authors.forename: Afshin
authors.initials: A
authors.lastname: Rezazadeh
authors.affiliation: d Department of Statistics, Faculty of Public Health , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Zarei
authors.affiliation: e Department of Food Hygiene, Faculty of Veterinary Medicine , Shahid Chamran University of Ahvaz , Ahvaz , IRAN.
authors.forename: Kambiz Ahmadi
authors.initials: KA
authors.lastname: Engali
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D020738:Leptin / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000188:drug therapy*; D010919:Placebos; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D010919:Placebos; D014409:Tumor Necrosis Factor-alpha; D014451:Ubiquinone; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; C024989:coenzyme Q10
keywords: adipocytokines; coenzyme Q10 (CoQ10); inflammation; nonalcoholic fatty liver disease (NAFLD)