title: The Decline of Pertussis-Specific Antibodies After Tetanus, Diphtheria, and Acellular Pertussis Immunization in Late Pregnancy.
abstract: We prospectively measured pertussis-specific antibodies 9-15 months after delivery in women immunized with tetanus, diphtheria, and acellular pertussis (Tdap) after the 20th week of their recent pregnancy. The Tdap-immunized women (n = 38) exhibited a decline in geometric mean concentrations between their peripartum and follow-up levels for immunoglobulin G to pertussis toxin (21.48 [95% confidence interval, 12.51-36.89] vs 11.72 [7.09-19.37] IU/mL];); filamentous hemagglutinin (185.95 [157.93-218.94] vs 140.33 IU/mL [113.46-173.57] IU/mL); and pertactin (171.52 [120.73-243.67] vs 83.74 [60.58-115.75] IU/mL) (all P < .001). For women immunized with Tdap during late pregnancy, pertussis-specific immunoglobulin G levels decreased significantly 9-15 months after delivery.
authors.affiliation: Department of Pediatrics The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
authors.forename: Bahaa
authors.initials: B
authors.lastname: Abu Raya
authors.affiliation: Department of Pediatrics Clinical Microbiology Laboratory The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
authors.forename: Isaac
authors.initials: I
authors.lastname: Srugo
authors.affiliation: Division of Allergy and Clinical Immunology, Bnai Zion Medical Center The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
authors.forename: Aharon
authors.initials: A
authors.lastname: Kessel
authors.affiliation: Clinical Microbiology Laboratory.
authors.forename: Michael
authors.initials: M
authors.lastname: Peterman
authors.affiliation: The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
authors.forename: Avraham
authors.initials: A
authors.lastname: Vaknin
authors.affiliation: Clinical Microbiology Laboratory The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
authors.forename: Ellen
authors.initials: E
authors.lastname: Bamberger
mesh_terms: D018829:Adhesins, Bacterial / Q000276:immunology; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008875:Middle Aged; D037342:Pertussis Toxin / Q000276:immunology; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D010566:Virulence Factors, Bordetella / Q000276:immunology; D055815:Young Adult
chemical_list: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D007074:Immunoglobulin G; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis; C068929:pertactin; D037342:Pertussis Toxin
keywords: immunoglobulin G; maternal immunization; pertussis; pertussis toxin; tetanus-diphtheria-acellular pertussis