title: Calcium Carbonate Nanoplate Assemblies with Directed High-Energy Facets: Additive-Free Synthesis, High Drug Loading, and Sustainable Releasing.
abstract: Developing drug delivery systems (DDSs) with high drug-loading capacity and sustainable releasing is critical for long-term chemotherapeutic efficacy, and it still remains challenging. Herein, vaterite CaCO3 nanoplate assemblies with exposed high-energy {001} facets have been synthesized via a novel, additive-free strategy. The product shows a high doxorubicin-loading capacity (65%); the best of all the CaCO3-based DDSs so far. Also, the product's sustainable releasing performance and its inhibition of the initial burst release, together, endow it with long-term drug efficacy. The work may shed light on exposing directed high-energy facets for rationally designing of a drug delivery system with long-term efficacy.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Xie
authors.affiliation: §Laboratory of Inorganic Materials Chemistry, University of Namur, B-5000 Namur, Belgium.
authors.forename: Bao-Lian
authors.initials: BL
authors.lastname: Su
authors.forename: Bin
authors.initials: B
authors.lastname: Yao
authors.forename: Yixia
authors.initials: Y
authors.lastname: Yin
authors.forename: Shipu
authors.initials: S
authors.lastname: Li
authors.affiliation: ∥Department of Medicine Experiment, Wuhan General Hospital, Wuhan 430070, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Zhengyi
authors.initials: Z
authors.lastname: Fu
mesh_terms: D065966:Absorption, Physicochemical; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects*; D002119:Calcium Carbonate / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry*; D004735:Energy Transfer; D056945:Hep G2 Cells; D006801:Humans; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D013499:Surface Properties
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D004317:Doxorubicin; D002119:Calcium Carbonate
keywords: additive-free synthesis; calcium carbonate; drug delivery; high-energy facet; nanostructure