title: [Genotype of Rotavirus Vaccine Strain LLR in China is G10P[15]].
abstract: Rotavirus is the leading causal agent of severe acute gastroenteritis in children aged <5 years. A specific pharmacologic agent for the treatment of rotavirus-infected children is lacking. In China, only the Luo Tewei oral vaccine (Lanzhou Institute of Biological Products, Shanghai, China), which is produced from Lanzhou lamb rotavirus vaccine (LLR), is available. Studies have hypothesized that the genotype of LLR is G10P[12], To identify the genotype of LLR by reverse transcription-polymerase chain reaction, we showed that the VP7 and VP4 genotypes of LLR were G10 and P[15], respectively, based on sequencing, alignment and phylogenetic analyses. In conclusion, we identified the genotype of rotavirus strain LLR to be G10P[15].
authors.forename: Dandi
authors.initials: D
authors.lastname: Li
authors.forename: Ziqian
authors.initials: Z
authors.lastname: Xu
authors.forename: Guangcheng
authors.initials: G
authors.lastname: Xie
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xiaoman
authors.initials: X
authors.lastname: Sun
authors.forename: Nijun
authors.initials: N
authors.lastname: Guo
authors.forename: Lili
authors.initials: L
authors.lastname: Pang
authors.forename: Zhaojun
authors.initials: Z
authors.lastname: Duan
mesh_terms: D002681:China; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012401:Rotavirus / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000821:virology*; D022243:Rotavirus Vaccines / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D022243:Rotavirus Vaccines; D014764:Viral Proteins