title: Neutrophil-lymphocyte and platelet-lymphocyte ratios as inflammation markers for bipolar disorder.
abstract: In the present study we investigated the involvement of inflammatory cells and their ratios as inflammation markers in Bipolar Disorder. We have enrolled 61 manic, 55 euthymic patients and 54 control subjects to the study. Neutrophil-lymphocyte and platelet-lymphocyte ratios were found significantly higher in both manic and euthymic patients compared to control group. These findings suggest that the inflammatory cells have a role in the pathophysiology of bipolar disorder manic and even in euthymic state.
authors.affiliation: Department of Psychiatry, Bakırköy Mental Health Research and Training State Hospital, Istanbul, Turkey. Electronic address: tevfikkaleli@hotmail.com.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Kalelioglu
authors.affiliation: Department of Psychiatry, Bakırköy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akkus
authors.affiliation: Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Karamustafalioglu
authors.affiliation: Department of Psychiatry, Bakırköy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Genc
authors.affiliation: Department of Psychiatry, Bakırköy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Esra Sena
authors.initials: ES
authors.lastname: Genc
authors.affiliation: Department of Psychiatry, Bakırköy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Alparslan
authors.initials: A
authors.lastname: Cansiz
authors.affiliation: Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Emul
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators
keywords: Bipolar Disorder; Neutrophil–Lymphocyte Ratio; Platelet-Lymphocyte Ratio