title: Blood flow velocity vector field reconstruction from dual-beam bidirectional Doppler OCT measurements in retinal veins.
abstract: In this paper, we demonstrate the possibility to reconstruct the actual blood flow velocity vector field in retinal microvessels from dual-beam bidirectional Doppler optical coherence tomography measurements. First, for a better understanding of measured phase patterns, several flow situations were simulated on the basis of the known dual beam measurement geometry. We were able to extract the vector field parameters that determine the measured phase pattern, allowing for the development of an algorithm to reconstruct the velocity vector field from measured phase data. In a next step, measurements were performed at a straight vessel section and at a venous convergence; the obtained phase data were evaluated by means of the new approach. For the straight vessel section, the reconstructed flow velocity vector field yielded a parabolic flow. For the venous convergence, however, the reconstructed vector field deviated from a parabolic profile, but was in very good accordance with the simulated vector field for the given vessel geometry. The proposed algorithm allows predictions of the velocity vector field. Moreover, the algorithm is also sensitive to directional changes of the flow velocity as small as <1°, thereby offering insight in the flow characteristics of the non-Newtonian fluid blood in microvessels.
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, Austria.
authors.forename: Gerold C
authors.initials: GC
authors.lastname: Aschinger
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20/6L, A-1090 Vienna, Austria.
authors.forename: Leopold
authors.initials: L
authors.lastname: Schmetterer
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, Austria.
authors.forename: Veronika
authors.initials: V
authors.lastname: Doblhoff-Dier
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria.
authors.forename: Rainer A
authors.initials: RA
authors.lastname: Leitgeb
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20/6L, A-1090 Vienna, Austria.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Garhöfer
authors.affiliation: Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Gröschl
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria.
authors.forename: René M
authors.initials: RM
authors.lastname: Werkmeister
keywords: (110.4500) Optical coherence tomography; (170.2655) Functional monitoring and imaging; (280.2490) Flow diagnostics