title: Development of Robust and Recoverable Ultralow-Fouling Coatings Based on Poly(carboxybetaine) Ester Analogue.
abstract: Polyurethane with zwitterionic side chains (PCB-ester-PU) based on a poly(carboxybetaine) ester analogue is developed for marine coatings and biomedical applications by introducing dihydroxy-terminated PCB-ester(OH)2 with different polymerization as the macrodiol, 4,4'-diphenylmethane diisocyanate (MDI) as the diisocyanate, and 1,4-butanediol (1,4-BD) as the chain extender. Robust coatings are obtained and exhibit long-term excellent resistance to nonspecific protein adsorption, bacterial adhesion, and human umbilical vein endothelial cell (HUVEC) attachment after hydrolysis. Tests of adhesion on different substrates and film hardness indicate that the material possesses far more stable mechanic properties than hydrogel coatings. Moreover, such a resistance can be generated not only by alkaline solution, but also by a physiological buffer (such as phosphate-buffered saline (0.15 M pH 7.4 PBS)) or by steam in an autoclave. Ultimately, its excellent long-term nonfouling property, its healing capability through self-regeneration and superior mechanic properties (such as hardness and elasticity), and its good adhesiveness as a paint on both polar and nonpolar substrates make this material an ideal candidate as a coating for marine and medical devices.
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Wang
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Longgang
authors.initials: L
authors.lastname: Wang
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Lin
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Fangqin
authors.initials: F
authors.lastname: Ji
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Guanglong
authors.initials: G
authors.lastname: Ma
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Zhefan
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: †Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.|‡Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
authors.forename: Shengfu
authors.initials: S
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D001422:Bacterial Adhesion / Q000187:drug effects; D002072:Butylene Glycols / Q000737:chemistry; D002448:Cell Adhesion / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D004952:Esters; D006244:Hardness; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006868:Hydrolysis; D007074:Immunoglobulin G / Q000737:chemistry / Q000378:metabolism; D017953:Isocyanates / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry; D013211:Staphylococcus aureus / Q000502:physiology; D013499:Surface Properties; D001559:Benzhydryl Compounds
chemical_list: D002072:Butylene Glycols; D020099:Coated Materials, Biocompatible; D004952:Esters; D007074:Immunoglobulin G; D017953:Isocyanates; D011108:Polymers; D011140:Polyurethanes; C039681:1,4-butanediol; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds
keywords: carboxybetaine; coatings; hydrolysis; nonfouling; polyurethane; zwitterionic polymers