title: Ischemia-modified albumin as an oxidative stress biomarker in early pregnancy loss.
abstract: OBJECTIVE
  This study aimed to determine the association between early pregnancy loss and serum ischemia-modified albumin (IMA) concentrations.
  
  
  METHODS
  Serum samples of 180 women that included healthy pregnant women, women admitted for termination of pregnancy due to the absence of fetal cardiac activity or absence of fetal pole on ultrasonographic examination, and healthy non-pregnant women attending for gynecological examination. Each group included 60 patients. Serum concentrations of IMA were compared among the groups, and the correlations with patients' age, gravidity, BMI, gestational age and total serum albumin concentrations were calculated.
  
  
  RESULTS
  When the groups were compared with respect to IMA concentrations, the group with early pregnancy loss was found to have significantly higher IMA concentrations (p < 0.001). An IMA threshold of >163 ng/mL had a sensitivity of 75%, specificity of 55% to discriminate between healthy pregnant patients and patients with early pregnancy loss in first trimester.
  
  
  CONCLUSIONS
  Our findings support the theory that possible oxidative stress, a more hypoxic environment and defective placentation lead to increased serum IMA concentrations. These findings may help to shed light on the complicated pathogenesis of early pregnancy loss.
authors.affiliation: a Department of Obstetrics and Gynaecology , Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Cengiz
authors.affiliation: a Department of Obstetrics and Gynaecology , Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Hediye
authors.initials: H
authors.lastname: Dagdeviren
authors.affiliation: a Department of Obstetrics and Gynaecology , Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Ammar
authors.initials: A
authors.lastname: Kanawati
authors.affiliation: a Department of Obstetrics and Gynaecology , Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Suzen Çaypinar
authors.affiliation: a Department of Obstetrics and Gynaecology , Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yesil
authors.affiliation: a Department of Obstetrics and Gynaecology , Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ekin
authors.affiliation: a Department of Obstetrics and Gynaecology , Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Yasar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005313:Fetal Death; D006801:Humans; D018384:Oxidative Stress; D011247:Pregnancy; D012372:ROC Curve; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: Defective placentation; early pregnancy loss; ischemia-modified albumin; oxidative stress