title: Blood hypercoagulability and systemic inflammation in horses with heaves.
abstract: As inflammation and coagulation are intertwined processes, the efficiency of blood coagulation of heaves-affected horses and controls were compared in an observational case-control study, using thrombelastography. In experiment 1 (Exacerbation, six heaves, five controls), horses were housed indoors and fed hay. Thrombelastography, functional fibrinogen, platelet count, hematology, and antithrombin were measured. In experiment 2 (Remission, eight heaves, 11 controls), horses were housed in a low-dust environment for at least a month when thrombelastography was performed. Heaves-affected horses in exacerbation had greater maximum amplitude and higher functional fibrinogen than controls. Heaves-affected horses in clinical remission had greater maximum amplitude than controls. The hypercoagulable state and systemic inflammation of horses with heaves may be a consequence of pulmonary inflammation and may contribute to the perpetuation of airway dysfunction.
authors.affiliation: Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, J2S 7C6, Québec, Canada. Electronic address: mathilde.leclere@umontreal.ca.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Leclere
authors.affiliation: Department of Pathology and Microbiology, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, J2S 7C6, Québec, Canada.
authors.forename: Christian
authors.initials: C
authors.lastname: Bédard
authors.affiliation: Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, J2S 7C6, Québec, Canada.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Cortes-Dubly
authors.affiliation: Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, J2S 7C6, Québec, Canada.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lavoie
mesh_terms: D000818:Animals; D006734:Horse Diseases / Q000097:blood* / Q000473:pathology; D006736:Horses; D007249:Inflammation / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D013916:Thrombelastography / Q000662:veterinary; D019851:Thrombophilia / Q000097:blood / Q000473:pathology / Q000662:veterinary*
keywords: Coagulation; Inflammation; Recurrent airway obstruction