title: ROS1 rearranged non-small cell lung cancer brain metastases respond to low dose radiotherapy.
abstract: We present a young woman with ROS1 gene rearranged non-small cell lung cancer (NSCLC) with brain metastases. ROS is a proto-oncogene tyrosine protein kinase. The patient received a partial course of whole brain radiation therapy and experienced a sustained partial response in the brain. We hypothesize that ROS1 rearranged NSCLC brain metastases may be particularly sensitive to radiation therapy.
authors.affiliation: Department of Neurology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA. Electronic address: rlukas@neurology.bsd.uchicago.edu.
authors.forename: Rimas V
authors.initials: RV
authors.lastname: Lukas
authors.affiliation: Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Hasan
authors.affiliation: Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Martin K
authors.initials: MK
authors.lastname: Nicholas
authors.affiliation: Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, USA.
authors.forename: Ravi
authors.initials: R
authors.lastname: Salgia
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics* / Q000532:radiotherapy* / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000532:radiotherapy* / Q000556:secondary; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human
keywords: Brain metastases; Crizotinib; Non-small cell lung cancer; ROS1; Radiotherapy