title: Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan.
abstract: BACKGROUND
  Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. The risk of TFA, however, has not been well clarified in Japan. We investigated the association of serum TFA concentration with serum lipid profile, coronary risk factors, and prevalence of CAD.
  
  
  RESULTS
  A total of 902 patients, who were hospitalized at Kobe University Hospital from July 2008 to March 2012 and gave written informed consent, were enrolled in this study. Among them, 463 patients had CAD, and 318 patients had metabolic syndrome (MetS). Serum TFA, elaidic acid (trans-9-C18:1) and linolelaidic acid (trans-9, 12-C18:2), were measured on gas chromatography/mass spectrometry. Serum TFA level had a positive correlation with body mass index, waist circumference, low-density lipoprotein cholesterol, triglycerides, and apolipoprotein B48, and an inverse correlation with age and high-density lipoprotein cholesterol. Fasting serum TFA, by age quartile in the young generation with CAD and/or MetS, was higher than that in patients without CAD and/or MetS. On multivariate logistic regression, TFA was identified as a CAD risk after adjustment for classical risk factors.
  
  
  CONCLUSIONS
  Serum TFA concentration was elevated in young patients with CAD and/or MetS. Diet-derived TFA may cause a serious health problem, particularly in the young generation in Japan.
authors.affiliation: Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine.
authors.forename: Kenta
authors.initials: K
authors.lastname: Mori
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Ishida
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Minoru
authors.initials: M
authors.lastname: Hasokawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Monguchi
authors.forename: Maki
authors.initials: M
authors.lastname: Sasaki
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kondo
authors.forename: Hideto
authors.initials: H
authors.lastname: Nakajima
authors.forename: Masakazu
authors.initials: M
authors.lastname: Shinohara
authors.forename: Toshiro
authors.initials: T
authors.lastname: Shinke
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Irino
authors.forename: Ryuji
authors.initials: R
authors.lastname: Toh
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Nishimura
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000367:Age Factors; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000139:chemically induced* / Q000453:epidemiology*; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology; D008875:Middle Aged; D019301:Oleic Acid / Q000097:blood; D009829:Oleic Acids; D015995:Prevalence; D044242:Trans Fatty Acids / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D004041:Dietary Fats; D009829:Oleic Acids; D044242:Trans Fatty Acids; D019301:Oleic Acid; C011459:elaidic acid