title: ICAM-1 molecular mechanism and genome wide SNP's association studies.
abstract: Macrophages transformed foam cell formation occurs as a result of leukocyte accumulation mediated through intercellular adhesion molecule 1 (ICAM1), vascular cell adhesion molecule 1 (VCAM1), and E-selectin, secreted by inflamed or damaged endothelium. The key molecule is the ICAM-1, member of the adhesion immunoglobulin super family that maps to chromosome 19 p13.2-p13.3 codes for 505 amino acids have five extracellular domains including circulatory leukocytes binding site (primarily monocytes) for recruiting it at the sites of inflammation and the tight adhesion with vascular endothelium for the above mentioned pathogenesis as an initial step. Hence the objective of the current paper is to review the Genome Wide Association (GWA) studies and summarizes its understanding of functional Single Nucleotide Polymorphism (SNP's) of ICAM-1 clinical association to provide better guidance for the clinicians and researchers of the merits, demerits of the current results and direct them to do research on larger number of population for better prospective.
authors.affiliation: PhD Scholar, Department of Biotechnology, Sathyabama University, Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai 600 119, India; Physician Assistant, Department of Cardiology, Madras Medical Mission, Institute of Cardiovascular Diseases, Dr. J.J. Nagar, Mogappair, Chennai 600 037, India. Electronic address: anbarasanc@yahoo.com.
authors.forename: C
authors.initials: C
authors.lastname: Anbarasan
authors.affiliation: Associate Professor, Department of Biotechnology, Sathyabama University, Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai 600 119, India.
authors.forename: M
authors.initials: M
authors.lastname: Bavanilatha
authors.affiliation: Head of Cardiac catheterization Laboratory, Department of Cardiology, Madras Medical Mission, Institute of Cardiovascular Diseases, Dr. J.J. Nagar, Mogappair, Chennai 600 037, India.
authors.forename: K
authors.initials: K
authors.lastname: Latchumanadhas
authors.affiliation: Director - Cardiology, Department of Cardiology, Madras Medical Mission, Institute of Cardiovascular Diseases, Dr. J.J. Nagar, Mogappair, Chennai 600 037, India.
authors.forename: S
authors.initials: S
authors.lastname: Ajit Mullasari
mesh_terms: D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology; D055106:Genome-Wide Association Study; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics* / Q000378:metabolism; D018384:Oxidative Stress; D020641:Polymorphism, Single Nucleotide; D014652:Vascular Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D066253:Vascular Remodeling; D014664:Vasodilation / Q000502:physiology*
chemical_list: C573420:ICAM1 protein, human; D018799:Intercellular Adhesion Molecule-1
keywords: Genome wide association study; ICAM; SNP