title: Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties.
abstract: Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (-)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (-)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (-)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (-)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening.
authors.affiliation: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. eric.chu@astellas.com.
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Chu
authors.affiliation: Department of Nursing, Tzu Hui Institute of Technology, Pingtung County 926, Taiwan. beagleliu@gmail.com.
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Liu
authors.affiliation: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. meinch@kmu.edu.tw.
authors.forename: Mei-Ing
authors.initials: MI
authors.lastname: Chung
authors.affiliation: Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan. xx377@fy.edu.tw.
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D029562:Magnoliaceae / Q000737:chemistry*; D008543:Melanins / Q000037:antagonists & inhibitors*; D008546:Melanoma, Experimental / Q000473:pathology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008543:Melanins; D010936:Plant Extracts
keywords: Magnoliaceae; Michelia compressa var. lanyuensis; melanin; tyrosinase activity