title: [Micro RNA and its role in the pathophysiology of spinal cord injury - a further step towards neuroregenerative medicine].
abstract: In the pathophysiology of spinal cord injury, the secondary biological processes involving changes in gene expression become more important day a day. Within these changes, the expression of different microRNAs has been involved in some of the pathophysiological processes of spinal cord injury. There are several studies that describe the transient expression of microRNA in spinal cord injury, some of them related to inflammation and apoptosis and others to functional recovery and regeneration. MicroRNA may be a potential target for the treatment of spinal cord injury, modifying the processes of inflammation, oxidation, apoptosis, functional recovery and regeneration. It is necessary to continue the study of microRNAs in spinal cord injury, as well as the identification of their target genes and signaling mechanisms involved in its neurological effects. With this, the ultimate goal is the development of effective and safe therapeutic and diagnostic strategies for patients with spinal cord injury.
authors.affiliation: División de Rehabilitación Neurológica, Instituto Nacional de Rehabilitación, México D.F., México. Electronic address: jimenaqf@hotmail.com.
authors.forename: Jimena
authors.initials: J
authors.lastname: Quinzaños-Fresnedo
authors.affiliation: División de Rehabilitación Cardiaca, Instituto Nacional de Rehabilitación, México D.F., México.
authors.forename: Roberto Carlos
authors.initials: RC
authors.lastname: Sahagún-Olmos
mesh_terms: D000558:Ambystoma mexicanum; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D005911:Gliosis / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D007249:Inflammation / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics*; D023421:Models, Animal; D009416:Nerve Regeneration / Q000235:genetics; D009841:Oligonucleotides / Q000627:therapeutic use; D010084:Oxidation-Reduction; D051381:Rats; D020127:Recovery of Function; D044968:Regenerative Medicine / Q000379:methods*; D013116:Spinal Cord / Q000378:metabolism / Q000502:physiology; D013119:Spinal Cord Injuries / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy
chemical_list: D035683:MicroRNAs; D009841:Oligonucleotides
keywords: Fisiopatología; Lesión medular; Micro ARN; Micro RNA; Pathophysiology; Spinal cord injuries