title: Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells.
abstract: BACKGROUND
  Use of Carica papaya leaf extracts, reported to improve thrombocyte counts in dengue patients, demands further analysis on the underlying mechanism of its thrombopoietic cytokines induction
  
  
  METHODS
  In vitro cultures of peripheral blood leukocytes (PBL) and stem cells from human exfoliated deciduous teeth (SHED) were treated with unripe papaya pulp juice (UPJ) to evaluate its potential to induce thrombopoietic cytokines (IL-6 and SCF) RESULTS: In vitro scratch gap closure was significantly faster (p < .05) in SHED culture treated with UPJ. IL-6 concentration was significantly increased (p < .05) in SHED and PBL culture supernatant when treated with UPJ. SCF synthesis in SHED culture was also significantly increased (p < .05) when treated with UPJ CONCLUSION: In vitro upregulated synthesis of IL -6 and SCF both in PBL and SHED reveals the potential mechanism of unripe papaya to induce thrombopoietic cytokines synthesis in cells of hematopoietic and mesenchymal origin.
authors.affiliation: Faculty of Science, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan, 25200, Malaysia. jazliaziz87@gmail.com.
authors.forename: Jazli
authors.initials: J
authors.lastname: Aziz
authors.affiliation: Faculty of Dentistry, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan, 25200, Malaysia. noorlide@iium.edu.my.
authors.forename: Noor Lide
authors.initials: NL
authors.lastname: Abu Kassim
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, University Malaya, Kuala Lumpur, 50603, Malaysia. nhayaty@um.edu.my.
authors.forename: Noor Hayaty
authors.initials: NH
authors.lastname: Abu Kasim
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, University Malaya, Kuala Lumpur, 50603, Malaysia. tanna.bge@gmail.com.
authors.forename: Nazmul
authors.initials: N
authors.lastname: Haque
authors.affiliation: Faculty of Science, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan, 25200, Malaysia. m.tariqur.rahman@gmail.com.
authors.forename: Mohammad Tariqur
authors.initials: MT
authors.lastname: Rahman
mesh_terms: D029441:Carica / Q000737:chemistry*; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology; D059630:Mesenchymal Stem Cells / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D014094:Tooth, Deciduous / Q000166:cytology
chemical_list: D016207:Cytokines; D010936:Plant Extracts