title: Glycerophospholipid synthesis and functions in Pseudomonas.
abstract: The genus Pseudomonas is one of the most heterogeneous groups of eubacteria, presents in all major natural environments and in wide range of associations with plants and animals. The wide distribution of these bacteria is due to the use of specific mechanisms to adapt to environmental modifications. Generally, bacterial adaptation is only considered under the aspect of genes and protein expression, but lipids also play a pivotal role in bacterial functioning and homeostasis. This review resumes the mechanisms and regulations of pseudomonal glycerophospholipid synthesis, and the roles of glycerophospholipids in bacterial metabolism and homeostasis. Recently discovered specific pathways of P. aeruginosa lipid synthesis indicate the lineage dependent mechanisms of fatty acids homeostasis. Pseudomonas glycerophospholipids ensure structure functions and play important roles in bacterial adaptation to environmental modifications. The lipidome of Pseudomonas contains a typical eukaryotic glycerophospholipid--phosphatidylcholine -, which is involved in bacteria-host interactions. The ability of Pseudomonas to exploit eukaryotic lipids shows specific and original strategies developed by these microorganisms to succeed in their infectious process. All compiled data provide the demonstration of the importance of studying the Pseudomonas lipidome to inhibit the infectious potential of these highly versatile germs.
authors.affiliation: Normandie University of Rouen, Laboratory of Microbiology Signals and Microenvironment (LMSM), EA 4312, 55 rue St. Germain, 27000 Evreux, France.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kondakova
authors.affiliation: Centre de Biophysique Moléculaire, CNRS, UPR4301, rue Charles Sadron, 45071 Orléans, France.
authors.forename: François
authors.initials: F
authors.lastname: D'Heygère
authors.affiliation: Normandie University of Rouen, Laboratory of Microbiology Signals and Microenvironment (LMSM), EA 4312, 55 rue St. Germain, 27000 Evreux, France.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Feuilloley
authors.affiliation: Normandie University of Rouen, Laboratory of Microbiology Signals and Microenvironment (LMSM), EA 4312, 55 rue St. Germain, 27000 Evreux, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: Orange
authors.affiliation: Department of Environmental Biotechnology, UFZ Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.
authors.forename: Hermann J
authors.initials: HJ
authors.lastname: Heipieper
authors.affiliation: Normandie University of Rouen, Laboratory of Microbiology Signals and Microenvironment (LMSM), EA 4312, 55 rue St. Germain, 27000 Evreux, France. Electronic address: cecile.poc@univ-rouen.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Duclairoir Poc
mesh_terms: D020404:Glycerophospholipids / Q000096:biosynthesis* / Q000737:chemistry / Q000378:metabolism*; D011549:Pseudomonas / Q000378:metabolism*
chemical_list: D020404:Glycerophospholipids
keywords: Biosynthesis; Host; Interactions; Lineage; Lipidomics; Membranes; Phosphatidylcholine; Phospholipids