title: New phenyl derivatives from endophytic fungus Botryosphaeria sp. SCSIO KcF6 derived of mangrove plant Kandelia candel.
abstract: Two new phenyl derivatives (1 and 3), along with two new natural products (4 and 5), and three known compounds (2, 6 and 7), were isolated from an endophytic fungus Botryosphaeria sp. SCSIO KcF6. The structures of these compounds 1-7 were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds 1 and 3 were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound 3 exhibited a specific COX-2 inhibitory activity with the IC50 value of 1.12 μM.
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , P.R. China.|b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Zhi-ran
authors.initials: ZR
authors.lastname: Ju
authors.affiliation: c Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , P.R. China.
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Qin
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Xiu-ping
authors.initials: XP
authors.lastname: Lin
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Jun-feng
authors.initials: JF
authors.lastname: Wang
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Kumaravel
authors.initials: K
authors.lastname: Kaliyaperumal
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Yong-qi
authors.initials: YQ
authors.lastname: Tian
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , P.R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: c Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , P.R. China.
authors.forename: Zhengchao
authors.initials: Z
authors.lastname: Tu
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , P.R. China.
authors.forename: Shi-hai
authors.initials: SH
authors.lastname: Xu
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000502:physiology; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D060026:Endophytes / Q000737:chemistry; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D043982:Rhizophoraceae / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology; D053833:Wetlands
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D001688:Biological Products; D052246:Cyclooxygenase 2 Inhibitors; D012717:Sesquiterpenes; C000609496:botryosphaerin A; C000609498:botryosphaerin B
keywords: Botryosphaeria sp. SCSIO KcF6; COX-2 inhibitory activity; endophytic fungus