title: VGF expression by T lymphocytes in patients with Alzheimer's disease.
abstract: Secretion of VGF is increased in cerebrospinal fluid and blood in neurodegenerative disorders like Alzheimer's disease (AD) and VGF is a potential biomarker for these disorders. We have shown that VGF is expressed in peripheral T cells and is correlated with T cell survival and cytokine secretion. The frequency of VGF+CD3+ T cells increases with normal aging. We found an increased number of VGF-expressing T cells in patients with AD compared to aged healthy controls, which was associated with enhanced HbA1c levels in blood. Upon treatment with rivastigmine, T cell proliferation and VGF expression in AD patients decreased to the level found in controls. Moreover, rapamycin treatment in vitro reduced the number of VGF+CD3+ cells in AD patients to control levels.
authors.affiliation: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Busse
authors.affiliation: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.|Center for Behavioral Brain Sciences, University of Magdeburg, Magdeburg, Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Steiner
authors.affiliation: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Glorius
authors.affiliation: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Dobrowolny
authors.affiliation: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Greiner-Bohl
authors.affiliation: Department of Neuropathology, University of Magdeburg, Magdeburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Mawrin
authors.affiliation: Institute of Molecular and Clinical Immunology, University of Magdeburg, Magdeburg, Germany.
authors.forename: Ursula
authors.initials: U
authors.lastname: Bommhardt
authors.affiliation: Institute of Molecular and Clinical Immunology, University of Magdeburg, Magdeburg, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Hartig
authors.affiliation: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.|Center for Behavioral Brain Sciences, University of Magdeburg, Magdeburg, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Bogerts
authors.affiliation: Department of Pediatric Pulmonology, Allergology & Neonatology, Medical University of Hannover, Hannover, Germany.
authors.forename: Mandy
authors.initials: M
authors.lastname: Busse
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D017252:CD3 Complex / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005434:Flow Cytometry; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology; D000068836:Rivastigmine / Q000494:pharmacology / Q000627:therapeutic use; D020123:Sirolimus / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D017252:CD3 Complex; D006442:Glycated Hemoglobin; D007166:Immunosuppressive Agents; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D000068836:Rivastigmine; D020123:Sirolimus; C510637:VGF protein, human
keywords: Alzheimer’s disease; Gerotarget; T cells; VGF expression; rapamycin; rivastigmine