title: Implantable Self-Powered Low-Level Laser Cure System for Mouse Embryonic Osteoblasts' Proliferation and Differentiation.
abstract: Bone remodeling or orthodontic treatment is usually a long-term process. It is highly desirable to speed up the process for effective medical treatment. In this work, a self-powered low-level laser cure system for osteogenesis is developed using the power generated by the triboelectric nanogenerator. It is found that the system significantly accelerated the mouse embryonic osteoblasts' proliferation and differentiation, which is essential for bone and tooth healing. The system is further demonstrated to be driven by a living creature's motions, such as human walking or a mouse's breathing, suggesting its practical use as a portable or implantable clinical cure for bone remodeling or orthodontic treatment.
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , Beijing 100083, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , Beijing 100083, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Tian
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , Beijing 100083, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University , Beijing 100191, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yan
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University , Beijing 100191, China.
authors.forename: Jiangxue
authors.initials: J
authors.lastname: Wang
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , Beijing 100083, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Li
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , Beijing 100083, China.|School of Material Science and Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332-0245, United States.
authors.forename: Zhong Lin
authors.initials: ZL
authors.lastname: Wang
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000528:radiation effects*; D002460:Cell Line; D049109:Cell Proliferation / Q000528:radiation effects*; D011211:Electric Power Supplies; D004622:Embryo, Mammalian; D006801:Humans; D007259:Infrared Rays; D028022:Low-Level Light Therapy / Q000295:instrumentation*; D051379:Mice; D049329:Nanostructures / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology / Q000528:radiation effects*; D010012:Osteogenesis / Q000502:physiology / Q000528:radiation effects*
keywords: differentiation; embryonic osteoblast; low-level laser; proliferation; self-powered