title: Follicular phase serum and follicular fluid glycodelin measurements in gonadotropin-releasing hormone (GnRH)-antagonist assisted reproduction cycles: A prospective cohort study.
abstract: OBJECTIVE
  To establish the serum pattern for glycodelin and to investigate the possible correlations of serum and follicular fluid (FF) glycodelin with clinical pregnancy in gonadotropin-releasing hormone (GnRH)-antagonist controlled cycles.
  
  
  METHODS
  A prospective observational study conducted with 80 infertile couples who received a GnRH-antagonist controlled cycle. Glycodelin levels were measured in FF, day 2-3, and ovarian pick-up (OPU)-day serum samples.
  
  
  RESULTS
  There were no significant differences in serum glycodelin concentrations in either the early follicular phase or the preovulatory phase, and in FF glycodelin concentrations between clinically pregnant and non-pregnant patients. OPU-day serum glycodelin was found to be significantly higher than early follicular serum glycodelin level in all patients whether pregnancy occurred or not.
  
  
  CONCLUSIONS
  Although day 2-3 and OPU-day measurements of serum glycodelin levels were not significant in predicting clinical pregnancy, the pattern of serum glycodelin seems different in GnRH-antagonist controlled cycles than natural and GnRH-agonist controlled cycles.
authors.forename: H
authors.initials: H
authors.lastname: Hassa
authors.forename: Y
authors.initials: Y
authors.lastname: Aydin
authors.forename: T
authors.initials: T
authors.lastname: Isikci
authors.forename: S
authors.initials: S
authors.lastname: Oner
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry*; D005498:Follicular Phase / Q000378:metabolism*; D000071816:Glycodelin; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006062:Gonadotropins; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007246:Infertility / Q000628:therapy*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted; D016896:Treatment Outcome
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; D006062:Gonadotropins; D006727:Hormone Antagonists; C045246:PAEP protein, human; D007987:Gonadotropin-Releasing Hormone