title: Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region.
abstract: A novel GII.P17-GII.17 variant norovirus emerged as a major cause of norovirus outbreaks from December 2014 to March 2015 in Japan. Named Hu/GII/JP/2014/GII.P17-GII.17, this variant has a newly identified GII.P17 type RNA-dependent RNA polymerase, while the capsid sequence displays amino acid substitutions around histo-blood group antigen (HBGA) binding sites. Several variants caused by mutations in the capsid region have previously been observed in the GII.4 genotype. Monitoring the GII.17 variant's geographical spread and evolution is important.
authors.affiliation: Division of Virology, Kawasaki City Institute for Public Health, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsushima
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: A
authors.initials: A
authors.lastname: Komane
authors.forename: S
authors.initials: S
authors.lastname: Kasuo
authors.forename: M
authors.initials: M
authors.lastname: Shinohara
authors.forename: K
authors.initials: K
authors.lastname: Nagasawa
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: A
authors.initials: A
authors.lastname: Ryo
authors.forename: N
authors.initials: N
authors.lastname: Okabe
authors.forename: K
authors.initials: K
authors.lastname: Haga
authors.forename: Y H
authors.initials: YH
authors.lastname: Doan
authors.forename: K
authors.initials: K
authors.lastname: Katayama
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics; D004196:Disease Outbreaks; D004403:Dysentery / Q000453:epidemiology / Q000235:genetics*; D005243:Feces / Q000821:virology; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D029322:Norovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000235:genetics; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D036022:Capsid Proteins; D012367:RNA, Viral; D012324:RNA-Dependent RNA Polymerase