title: Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid-base interactions.
abstract: A series of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles were efficiently synthesized by cyclocondensation of the appropriate 3-(pyridyl)acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid. The products were identified by means of spectroscopic methods and their pKAionization constants were determined. The influence of substituents on the basicity of the pyridine system has been discussed.
authors.affiliation: Department of Chemical Organic Technology and Petrochemistry, The Silesian University of Technology, Krzywoustego 4, 44100 Gliwice, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kudelko
authors.affiliation: Department of Chemical Organic Technology and Petrochemistry, The Silesian University of Technology, Krzywoustego 4, 44100 Gliwice, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Jasiak
authors.affiliation: Faculty of Chemistry, Opole University, Oleska 48, 45052 Opole, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Ejsmont
keywords: 1,3,4-Oxadiazoles; 3-(Pyridyl)acrylohydrazides; Basicity; Cyclizations; Heterocycles; pKA Ionization constants