title: Downregulation of the long noncoding RNA EGOT correlates with malignant status and poor prognosis in breast cancer.
abstract: Eosinophil granule ontogeny transcript (EGOT) is a long noncoding RNA involved in the regulation of eosinophil granule protein transcript expression. However, little is known about the role of EGOT in malignant disease. This study aimed to assess the potential role of EGOT in the pathogenesis of breast cancer. Quantitative real-time polymerase chain reaction was performed to detect the expression levels of EGOT in 250 breast cancerous tissues and 50 adjacent noncancerous tissues. The correlation of EGOT expression with clinicopathological features and prognosis was also analyzed. EGOT expression was lower in breast cancer compared with the adjacent noncancerous tissues (P < 0.001), and low levels of EGOT expression were significantly correlated with larger tumor size (P = 0.022), more lymph node metastasis (P = 0.020), and higher Ki-67 expression (P = 0.017). Moreover, patients with low levels of EGOT expression showed significantly worse prognosis for overall survival (P = 0.040), and this result was further validated in a larger cohort from a public database. Multivariate analysis suggested that low levels of EGOT were a poor independent prognostic predictor for breast cancer patients (HR = 1.857, 95 % CI = 1.032-3.340, P = 0.039). In conclusion, EGOT may play an important role in breast cancer progression and prognosis and may serve as a new potential prognostic target in breast cancer patients.
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Shou-Ping
authors.initials: SP
authors.lastname: Xu
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Shi-Yao
authors.initials: SY
authors.lastname: Sui
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Nan-Xia
authors.initials: NX
authors.lastname: Bai
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Qing-Yu
authors.initials: QY
authors.lastname: Shi
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Zi-Long
authors.initials: ZL
authors.lastname: You
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhan
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150040, China. vipdon@126.com.|Heilongjiang Academy of Medical Sciences, 157 Baojian Road, Harbin, 150086, China. vipdon@126.com.|Sino-Russian Medical Research Center, Heilongjiang Academy of Medical Sciences, 157 Baojian Road, Harbin, 150086, China. vipdon@126.com.|Northern (China) Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, 157 Baojian Road, Harbin, 150086, China. vipdon@126.com.
authors.forename: Da
authors.initials: D
authors.lastname: Pang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C000606999:EGOT lncRNA, human; D062085:RNA, Long Noncoding
keywords: Breast cancer; EGOT; Long noncoding RNA; Prognosis