title: HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist.
authors.affiliation: Houston Methodist Research Institute, Houston, TX, USA.
authors.forename: S G T
authors.initials: SG
authors.lastname: Devaraj
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: W
authors.initials: W
authors.lastname: Fiskus
authors.affiliation: Houston Methodist Research Institute, Houston, TX, USA.
authors.forename: B
authors.initials: B
authors.lastname: Shah
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Qi
authors.affiliation: Houston Methodist Research Institute, Houston, TX, USA.
authors.forename: B
authors.initials: B
authors.lastname: Sun
authors.affiliation: Houston Methodist Research Institute, Houston, TX, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Iyer
authors.affiliation: University of Utah, Huntsman Cancer Institute, Salt Lake City, UT, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Bradner
authors.affiliation: MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: K N
authors.initials: KN
authors.lastname: Bhalla
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001381:Azepines / Q000494:pharmacology; D018797:Cell Cycle Proteins; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D051379:Mice; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors*; D016601:RNA-Binding Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000037:antagonists & inhibitors*; D014230:Triazoles / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays; D000092468:Bromodomain Containing Proteins
chemical_list: D000970:Antineoplastic Agents; D001381:Azepines; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D014230:Triazoles; C561695:(+)-JQ1 compound; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C476123:HEXIM1 protein, human