title: Neglected Plasmodium vivax malaria in northeastern States of India.
abstract: OBJECTIVE
  The northeastern States of India are co-endemic for Plasmodium falciparum and P. vivax malaria. The transmission intensity is low-to-moderate resulting in intermediate to stable malaria. Malaria control prioritized P. falciparum being the predominant and life threatening infection (>70%). P. vivax malaria remained somewhat neglected. The present study provides a status report of P. vivax malaria in the northeastern States of India.
  
  
  METHODS
  Data on spatial distribution of P. vivax from seven northeastern States (Arunachal Pradesh, Assam, Manipur, Meghalaya, Mizoram, Nagaland and Tripura) were analysed retrospectively from 2008-2013. In addition, cross-sectional malarial surveys were conducted during 1991-2012 in malaria endemic pockets across the States of Assam, Meghalaya, Mizoram and Tripura to ascertain the prevalence of P. vivax in different age groups.
  
  
  RESULTS
  Vivax malaria was encountered in all northeastern States but there existed a clear division of two malaria ecotypes supporting ≤30 and >30 per cent of total malaria cases. High proportions of P. vivax cases (60-80%) were seen in Arunachal Pradesh and Nagaland in the north with alpine environment, 42-67 per cent in Manipur, whereas in Assam it varied from 23-31 per cent with subtropical and tropical climate. Meghalaya, Tripura and Mizoram had the lowest proportion of P. vivax cases. Malaria cases were recorded in all age groups but a higher proportion of P. vivax consistently occurred among <5 yr age group compared to P. falciparum (P<0.05). P. vivax cases were recorded throughout the year with peak coinciding with rainy season although transmission intensity and duration varied.
  
  
  CONCLUSIONS
  In northeast India, P. vivax is a neglected infection. Estimating the relapsing pattern and transmission dynamics of P. vivax in various ecological settings is an important pre-requisite for planning malaria elimination in the northeastern States.
authors.forename: Vinod P
authors.initials: VP
authors.lastname: Sharma
authors.affiliation: National Institute of Malaria Research (Field Station) (ICMR), Guwahati, Assam, India.
authors.forename: Vas
authors.initials: V
authors.lastname: Dev
authors.forename: Sobhan
authors.initials: S
authors.lastname: Phookan
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007194:India; D016780:Malaria, Vivax / Q000453:epidemiology* / Q000469:parasitology* / Q000635:transmission; D008297:Male; D010966:Plasmodium vivax / Q000472:pathogenicity*; D012189:Retrospective Studies; D012621:Seasons