title: [Autologous mesenchymal stem cells and cutaneus autograft as a treatment for chronic ulcer secondary to diabetes mellitus 2].
abstract: BACKGROUND
  Diabetes mellitus 2 has become a global problem. It is estimated that 15% to 25% of patients could develop a chronic ulcer in their life, and nearly 33% of direct care costs of the diabetes mellitus 2 is spent on treating these ulcers. Mesenchymal stem cells have emerged as a promising cell source for the treatment of these ulcers.
  
  
  METHODS
  The case is presented of a 67 year-old male with a history of diabetes mellitus, acute myocardial infarction, and food ulcer chronic involving right foot and part of his leg. He was treated with mesenchymal stem cell management, resulting in skin graft integration and full coverage of the lesion.
  
  
  CONCLUSIONS
  The implementation of mesenchymal stem cell techniques for treatment of chronic ulcer is feasible. The impact on the population would lead to a significant improvement in their quality of life and reduce healthcare spending.
authors.affiliation: Departamento de Laboratorio de Morfología Celular, Escuela Superior de Medicina, Instituto Politécnico Nacional, México D.F., México. Electronic address: gamaliel.benitez@imss.gob.mx.
authors.forename: Gamaliel
authors.initials: G
authors.lastname: Benítez-Arvízu
authors.affiliation: Departamento de Laboratorio de Morfología Celular, Escuela Superior de Medicina, Instituto Politécnico Nacional, México D.F., México.
authors.forename: Ícela
authors.initials: Í
authors.lastname: Palma-Lara
authors.affiliation: Servicio de Ortopedia, Hospital General de Puebla, Secretaria de Salud del estado de Puebla, Puebla, Puebla, México.
authors.forename: René
authors.initials: R
authors.lastname: Vazquez-Campos
authors.affiliation: Servicio de Ortopedia, Hospital General de Puebla, Secretaria de Salud del estado de Puebla, Puebla, Puebla, México.
authors.forename: Raimundo Alfonso
authors.initials: RA
authors.lastname: Sesma-Villalpando
authors.affiliation: Departamento de Laboratorio de Medicina Regenerativa y Cáncer, Escuela Superior de Medicina, Instituto Politécnico Nacional, México D.F., México.
authors.forename: Alberto
authors.initials: A
authors.lastname: Parra-Barrera
authors.affiliation: Departamento de Laboratorio de Medicina Regenerativa y Cáncer, Escuela Superior de Medicina, Instituto Politécnico Nacional, México D.F., México.
authors.forename: Gisela
authors.initials: G
authors.lastname: Gutiérrez-Iglesias
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001854:Bone Marrow Cells; D003646:Debridement; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D017719:Diabetic Foot / Q000209:etiology / Q000601:surgery*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D016523:Foot Ulcer / Q000209:etiology / Q000382:microbiology / Q000601:surgery*; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000382:microbiology / Q000601:surgery*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D016038:Skin Transplantation; D013207:Staphylococcal Skin Infections / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D020858:Tissue and Organ Harvesting / Q000379:methods; D014034:Toes / Q000601:surgery; D014182:Transplantation, Autologous; D014946:Wound Infection / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Chronic ulcer; Células troncales mesenquimales; Diabetes mellitus tipo2; Mesenchymal stem cells; Type2 diabetes mellitus; Úlcera crónica