title: Association between the MTHFR A1298C polymorphism and risk of cancer: evidence from 265 case-control studies.
abstract: Many molecular, epidemiological studies have been performed to explore the association between MTHFR A1298C polymorphism and cancer risk. However, the results were inconsistent or even contradictory. Hence, we performed a meta-analysis to investigate the association between cancer risk and MTHFR A1298C (81,040 cases and 114,975 controls from 265 studies) polymorphism. Overall, significant association was observed between MTHFR A1298C polymorphism and cancer risk when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, significantly increased cervical cancer (dominant model: OR 1.46, 95 % CI 1.13-1.90; AC vs. AA: OR 1.48, 95 % CI 1.13-1.92) and lymphoma (dominant model: OR 1.22, 95 % CI 1.04-1.44; recessive model: OR 1.66, 95 % CI 1.15-2.39; CC vs. AA: OR 1.75, 95 % CI 1.21-2.53) risk were observed in Asians, and significantly decreased colorectal cancer risk was found in Asians (recessive model: OR 0.75, 95 % CI 0.59-0.96; CC vs. AA: OR 0.77, 95 % CI 0.60-1.00). In summary, this meta-analysis suggests that MTHFR A1298C polymorphism is associated with increased cervical cancer and lymphoma risk in Asians, and MTHFR A1298C polymorphism is associated with decreased colorectal cancer risk in Asians. Moreover, this meta-analysis also points out the importance of new studies, such as oral cancer and chronic myeloid leukemia, because they had high heterogeneity in this meta-analysis (I (2) > 75 %).
authors.affiliation: Department of Radiotherapy, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
authors.forename: Xin-Li
authors.initials: XL
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, 519000, China.
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Liu
authors.affiliation: Department of Radiotherapy, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. yansenxiang@yeah.net.
authors.forename: Sen-Xiang
authors.initials: SX
authors.lastname: Yan
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, 519000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Radiotherapy, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. ruixiachang12@163.com.
authors.forename: Rui-Xia
authors.initials: RX
authors.lastname: Chang
authors.affiliation: Department of Obstetric, Peace Hospital of Changzhi Medical College, Changzhi, 046000, China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Zhang
authors.affiliation: Department of Obstetric, Peace Hospital of Changzhi Medical College, Changzhi, 046000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Cancer; MTHFR; Meta-analysis; Polymorphism; Susceptibility