title: CKS2 in human cancers: Clinical roles and current perspectives (Review).
abstract: Cyclin-dependent kinase subunit 2 (CKS2) is indicated in the processes of cell cycle and cell proliferation. Through these processes,CKS2is identified as a cancer gene, but its role has not been well reviewed. The aim of the present study was to summarize the clinicopathological significance and the molecular mechanisms ofCKS2in human cancers. Its expression was upregulated in the majority of the types of cancer studied.CKS2was shown to have a function in cancers of the digestive tract, genital tract, thyroid, nerve and certain other types of cancer.CKS2can promote progression of certain cancers via positive control of proliferation, invasion and migration. Downregulation ofCKS2induces cancer cell apoptosis.CKS2can change a multitude of cellular mechanisms in cancer pathogenesis by regulating the gene translation of numerous validated targets, such asp53, CDK1, cyclin A, cyclin B1, caspase-3 andBax. In addition, the molecular mechanism that causes aberrant expression ofCKS2was epigenetic modification ofmiR-26aand the Y-box-binding protein 1 (YB-1) gene. In conclusion,CKS2is commonly elevated in cancer, most likely due to its ability to promote cancer cell growth, invasion and migration through regulating certain significant genes. Understanding the mechanisms by whichCKS2is involved with cancer pathogenesis will be useful in the development of tumor therapy for patients with cancer.
authors.affiliation: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital, Xiamen, Fujian 361000, P.R. China.
authors.forename: Hanyu
authors.initials: H
authors.lastname: You
authors.affiliation: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital, Xiamen, Fujian 361000, P.R. China.
authors.forename: Huayue
authors.initials: H
authors.lastname: Lin
authors.affiliation: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital, Xiamen, Fujian 361000, P.R. China ; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian 361005, P.R. China.
authors.forename: Zhongying
authors.initials: Z
authors.lastname: Zhang
keywords: CKS2; biological function; cancer; clinicopathological features; molecular mechanisms