title: Frequency and outcome of treatment in polycystic ovaries related infertility.
abstract: BACKGROUND
  Infertility is defined as inability of couple to conceive after one year of unprotected intercourse. The prevalence of infertility in Pakistan is 21.9%. The most common cause of medically treatable infertility is polycystic ovarian syndrome (PCO). This study was conducted to see the frequency and outcome of treatment in PCOs related infertility in infertile couples coming to Mohammad Medical College Hospital, Mirpurkhas, Sindh.
  
  
  METHODS
  This prospective observational study was conducted at Muhammad Medical College for three years from 2005 to 2008. Total 1289 infertile couples were included in this study.
  
  
  RESULTS
  The frequency of PCOs in female related infertility was 38.5%. Other causes of female infertility were in the frequency of 44% pelvic inflammatory disease, 12.3% endometriosis, 2.9% hyperprolactenemia, and 1.35% hypothyroidism. Patients with PCOS were given different treatment modalities. One hundred fifty patients with PCO were given ovulation induction with clomephene citrate and out of them 109 (72%) conceived. Sixty three women were given combination of clomephene citrate and Metformin. Out of them 50 (79%) conceived. Five patients were given gonadotrophins, Out of them 2 (40%) patients conceived. Five patients had laparoscopic drilling out of them 3 (60%) conceived.
  
  
  CONCLUSIONS
  In contrast to the literature review Polycystic Ovarian Syndrome turned out to be the second most common cause of female related infertility. But as the international literature shows it had very good out come after medical and /or surgical treatment.
authors.affiliation: Dr. Farzana Arain, Associate Professor, Taif Medical College, Taif, Saudi Arabia.
authors.forename: Farzana
authors.initials: F
authors.lastname: Arain
authors.affiliation: Dr. Nesreen Arif, Assistant Professor, Taif Medical College, Taif, Saudi Arabia.
authors.forename: Nesreen
authors.initials: N
authors.lastname: Arif
authors.affiliation: Dr. Hafeez Halepota, Professor of Gynae & Obstetric Department, Muhammad Medical College Hospital, Mirpurkhas, Sindh, Pakistan.
authors.forename: Hafeez
authors.initials: H
authors.lastname: Halepota
keywords: Infertility; Laparoscopic ovarian drilling; Ovulation induction; Polycystic Ovaries