title: Synthesis and antifungal activity evaluation of new heterocycle containing amide derivatives.
abstract: A series of heterocycle containing amide derivatives (1-28) were synthesised by the combination of acyl chlorides (1a, 2a) and heterocyclic/homocyclic ring containing amines, and their in vitro antifungal activity was evaluated against five plant pathogenic fungi, namely Gibberella zeae, Helminthosporium maydis, Rhizoctonia solani, Botrytis cinerea and Sclerotinia sclerotiorum. Results of antifungal activity analysis indicated that some of the products showed good to excellent antifungal activity, as compound 2 showed excellent activity against G. zeae and R. solani and potent activity against H. maydi, B. cinerea and S. sclerotiorum, and compounds 1, 8 and 10 also displayed excellent antifungal potential against H. maydi, B. cinerea and S. sclerotiorum and good activity against R. solani when compared with the standard carbendazim.
authors.affiliation: a School of Physics and Chemistry, Xihua University , Chengdu 610039 , P.R. China.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Wang
authors.affiliation: a School of Physics and Chemistry, Xihua University , Chengdu 610039 , P.R. China.
authors.forename: Sumei
authors.initials: S
authors.lastname: Gao
authors.affiliation: a School of Physics and Chemistry, Xihua University , Chengdu 610039 , P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.affiliation: a School of Physics and Chemistry, Xihua University , Chengdu 610039 , P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: a School of Physics and Chemistry, Xihua University , Chengdu 610039 , P.R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: a School of Physics and Chemistry, Xihua University , Chengdu 610039 , P.R. China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Tang
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D001562:Benzimidazoles; D020171:Botrytis / Q000187:drug effects; D002219:Carbamates; D005670:Fusarium / Q000187:drug effects; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure; D010944:Plants / Q000382:microbiology; D012232:Rhizoctonia / Q000187:drug effects
chemical_list: D000577:Amides; D000935:Antifungal Agents; D001562:Benzimidazoles; D002219:Carbamates; C006698:carbendazim
keywords: amide derivatives; antifungal activity; plant pathogenic fungi; synthesis