title: Comparative Speed of Kill, Repellent (anti-feeding) and Acaricidal Efficacy of an Imidacloprid/Flumethrin Collar (Seresto®) and a Fipronil/(S)-Methoprene/Eprinomectin/Praziquantel Spot-on (Broadline®) against Ixodes ricinus (Linné, 1758) on Cats.
abstract: Speed of kill, repellent (anti-feeding) and acaricidal efficacy of an imidacloprid 10 % (w/w) /flumethrin 4.5 % (w/w) collar (Seresto(®), Bayer) and a spot-on formulation of fipronil 8.3 % (w/v) /(S)-methoprene 10 % (w/v) /eprinomectin 0.4 % (w/v) /praziquantel 8.3 % (w/v) (Broadline(®), Merial) against artificiallyinduced infestations with Ixodes ricinus on cats, were assessed in a parallel group design, randomised, controlled study. Twenty-four cats were included and randomly allocated to treatment groups or a non-treated control group. Starting on Day (D) 7 after treatment until D28, cats were each infested with 50 I. ricinus at weekly intervals. Ticks were counted in situ on the cats at 6, 12 and 24 h and upon removal 48 h after each infestation. Based on arithmetic means, Seresto(®) proved to be 100 % effective against adult I. ricinus at all assessment times (6, 12, 24 and 48 h after infestation) throughout the month-long study. Broadline(®) was 0 % to 16.7 % effective at 6 h, 26.8 % to 50.0 % effective at 12 h, while at 24 h after infestation efficacy peaked at 81.5 % on D15 declining to 31.5 % on D29. Based on the 48 h tick counts, the efficacy of Broadline(®) peaked at 100 % on D16 after treatment and decreased to 83.2 % by D30. The Seresto(®) collar provided significantly faster speed of kill and better persistent acaricidal effectiveness against Ixodes ricinus on cats compared to Broadline(®) spot-on. The additional repellent (anti-feeding) effect of Seresto(®) prevents parasites from taking a blood meal and thereby reduces the risk of vector-borne disease pathogen transmission.
authors.affiliation: ClinVet International, Universitas, Bloemfontein, 9321, South Africa, josephus.fourie@clinvet.com.
authors.forename: Josephus J
authors.initials: JJ
authors.lastname: Fourie
authors.forename: Ivan G
authors.initials: IG
authors.lastname: Horak
authors.forename: Christa
authors.initials: C
authors.lastname: de Vos
authors.forename: Katrin
authors.initials: K
authors.lastname: Deuster
authors.forename: Bettina
authors.initials: B
authors.lastname: Schunack
mesh_terms: D056810:Acaricides / Q000008:administration & dosage / Q000494:pharmacology*; D000287:Administration, Topical; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy / Q000469:parasitology*; D002415:Cats; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D018884:Ixodes / Q000187:drug effects*; D008726:Methoprene / Q000008:administration & dosage / Q000627:therapeutic use; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use; D011722:Pyrethrins / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D056810:Acaricides; D007093:Imidazoles; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011720:Pyrazoles; D011722:Pyrethrins; C041392:flumethrin; C082359:imidacloprid; D011223:Praziquantel; D007559:Ivermectin; C101434:eprinomectin; D008726:Methoprene; C082360:fipronil