title: Vitamin D deficiency and Alzheimer disease: Common links.
abstract: Vitamin D (VitD) deficiency is a worldwide epidemic with estimates of 1 billion affected. In addition to the classically known roles of VitD in calcium regulation and bone health, recent studies demonstrated VitD to be an essential/vital neurosteroid hormone playing a wide variety of essential protective and regulatory roles in the brain. This paper reviews much of the mounting evidence of the detrimental effects of VitD deficiency on the brain and the association of many of these common links with Alzheimer's disease (AD). We also discuss the beneficial effects seen from VitD supplementation. Based on this accumulation of studies, we propose that VitD screening should be performed at least in those individuals at risk for VitD deficiency and AD. With appropriate medical counsel, those found to be VitD deficient should be considered for appropriate supplementation.
authors.affiliation: College of Human Medicine, Translational Science and Molecular Medicine, Michigan State University, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: keeneyj2@msu.edu.
authors.forename: Jeriel T
authors.initials: JT
authors.lastname: Keeney
authors.affiliation: Department of Chemistry and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA. Electronic address: dabcns@email.uky.edu.
authors.forename: D Allan
authors.initials: DA
authors.lastname: Butterfield
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D006801:Humans; D014808:Vitamin D Deficiency / Q000378:metabolism*
keywords: Alzheimer's disease; Amyloid beta-peptide; Deficiency; Signaling; Therapeutic intervention; Vitamin D