title: Serum levels of alpha-1 acid glycoprotein and pentraxin 3 in patients with Behçet's disease and relationship with disease activity.
abstract: BACKGROUND
  To evaluate the relationship between disease activity and levels of alpha 1-acid glycoprotein and pentraxin 3 in patients with Behçet's disease (BD).
  
  
  METHODS
  Forty-eight patients with BD and 29 age- and gender-matched healthy control subjects were included in the study. Serum pentraxin 3 levels were measured using enzyme-linked immunosorbent assay (ng/ml), and alpha 1-acid glycoprotein levels were measured using nephelometry (mg/dl). Disease activity was assessed using the BD Current Activity Form (BDCAF).
  
  
  RESULTS
  Serum alpha-1 acid glycoprotein levels were significantly higher in patients with BD compared to the control group (P = 0.048). There were no significant differences between two groups in terms of levels of pentraxin 3 (P = 0.697). According to Pearson's analysis, alpha 1-acid levels are significantly positively correlated with erythrocyte sedimentation rate, C-reactive protein, and skin lesions and arthritis of BDCAF scores. Pentraxin 3 levels did not correlate with erythrocyte sedimentation rate, C-reactive protein, or any domains of BDCAF scores.
  
  
  CONCLUSIONS
  The results of the present study demonstrate that serum levels of alpha-1 acid glycoprotein were significantly higher in patients with BD relative to the control group. Alpha-1 acid glycoprotein is greatly associated with skin lesions and arthritis in patients with BD. We did not find high serum levels of PTX3 in patients with BD compared to healthy controls, and pentraxin 3 is not associated with disease activity in BD.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Yazmalar
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Batmaz
authors.affiliation: Department of Dermatology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Sula
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Yüzüncüyıl University, Van, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Alpaycı
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Aydın
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Türkçü
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yıldız
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Kaplan
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Bozkurt
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Abdullah Zubeyr
authors.initials: AZ
authors.lastname: Dağlı
authors.affiliation: Department of Physical Medicine and Rehabilitation, Memorial Hospital, Diyarbakır, Turkey.
authors.forename: Yahya Kemal
authors.initials: YK
authors.lastname: Burkan
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Mustafa Akif
authors.initials: MA
authors.lastname: Sarıyıldız
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000097:blood; D001528:Behcet Syndrome / Q000097:blood* / Q000473:pathology; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D012720:Severity of Illness Index; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D009961:Orosomucoid; D000683:Serum Amyloid P-Component; D000099153:Pentraxins