title: Palladium-catalyzed oxidative 6-exo-trig cyclization of 1,6-enynes: facile synthesis of bicyclo[4.1.0]heptan-5-ones.
abstract: We here describe a new palladium-catalyzed oxidative 6-exo-trig cyclization of 1,6-enynes at room temperature using tBuONO as an oxidant for the synthesis of 3-bicyclo[4.1.0]heptan-5-ones. This cascade strategy involves the hydration, cyclization and cyclopropanation sequence, and represents a new transition-metal-catalyzed oxidative cyclization of 1,6-enynes in a 6-exo-trig fashion.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. srj0731@hnu.edu.cn jhli@hnu.edu.cn.
authors.forename: Bang
authors.initials: B
authors.lastname: Liu
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.forename: Xuan-Hui
authors.initials: XH
authors.lastname: Ouyang
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li