title: Giant Esophageal GIST: Diagnostic and Therapeutic Challenge - Case Report.
abstract: GIST are rare mesenchymal tumors of the digestive tract (less than 1% of the digestive tract neoplasia). Of these, less than 1% are found in the esophagus. Surgery is the main treatment of GIST and is supported by targeted therapy with tyrosine kinase inhibitors like imatinibmesylate. We present the case of a female patient of 51 years, admitted in our clinic for a bulky tumor in the posterior mediastinum, diagnosed after investigations performed for fatigue for the great efforts. Clinical examination was unspecific. Chest X-ray and thoraco-abdominal CT identified a widening of the mediastinum through a posterior mediastinal tumor mass, determining a deviation to the left of the thoracic esophagus without causing not abledysphagia or respiratory symptoms. It was decided surgery by thoracotomy in V right intercostal space and total excision of the tumor was performed. Histopathology examination confirmed the preoperative suspicion of esophageal GIST. Prognosis is reserved, the risk of relapse is very high given the fact that the tumor was extracted fragmented. Currently the patient is under treatment with imatinib mesylate and entered into clinical and imaging follow-up program, according to clinical guidelines.
authors.forename: S
authors.initials: S
authors.lastname: Constantinoiu
authors.forename: M
authors.initials: M
authors.lastname: Gheorghe
authors.forename: L
authors.initials: L
authors.lastname: Popa
authors.forename: C
authors.initials: C
authors.lastname: Ciocea
authors.forename: C
authors.initials: C
authors.lastname: Iosif
authors.forename: R
authors.initials: R
authors.lastname: Tiutiuca
authors.forename: A
authors.initials: A
authors.lastname: Iordache
authors.forename: I
authors.initials: I
authors.lastname: Cordoş
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate