title: Association of Vitamin D Level with Clinicopathological Features in Breast Cancer.
abstract: A population-based relationship between low vitamin D status and increased cancer risk is now generally accepted. However there were only few studies reported on prognostic impact. To determine the effect of low vitamin D on progression of breast cancer, we conducted a cross-sectional analysis of vitamin D levels and clinico- pathological characteristics in 200 cases of breast cancer diagnosed during 2011-2012 at the National Cancer Institute of Thailand. Vitamin D levels were measured by high-performance liquid chromatography (HPLC). Clinical and pathological data were accessed to examine prognostic effects of vitamin D. We found that the mean vitamin D level was 23.0±6.61 ng/ml. High vitamin D levels (≥32 ng/ml) were detected in 7% of patients, . low levels (<32 ng/ml) in 93% Mean vitamin D levels for stages 1-4 were 26.1±6.35, 22.3±6.34, 22.2±6.46 and 21.3±5.42 ng/ml respectively (P=0.016) and 24.1 and 21.3 ng/ml for lymph node negative and positive cases (P=0.006). Low vitamin D level (<32 ng/ml) was significantly found in majority of cases with advanced stage of the disease (P=0.036), positive node involvement (P=0.030) and large tumors (P=0.038). Our findings suggest that low and decreased level of vitamin D might correlate with progression and metastasis of breast cancer.
authors.affiliation: Surgery Division, National Cancer Institute, Bangkok, Thailand E-mail : dr.somchai.t@gmail.com.
authors.forename: Somchai
authors.initials: S
authors.lastname: Thanasitthichai
authors.forename: Arkom
authors.initials: A
authors.lastname: Chaiwerawattana
authors.forename: Aree
authors.initials: A
authors.lastname: Prasitthipayong
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013785:Thailand / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology / Q000473:pathology*; D014815:Vitamins / Q000097:blood*
chemical_list: D014815:Vitamins; D014807:Vitamin D