title: Physiology of Bone.
abstract: Bone serves three main physiological functions: its mechanical nature provides support for locomotion and offers protection to vulnerable internal organs, it forms a reservoir for the storage of calcium and phosphate in the body, and it provides an environment for bone marrow production and haematopoietic cell development. The traditional view of bone as a passive tissue that responds to hormonal and dietary influences has changed over the past half century to one of bone as a dynamic adaptive tissue that responds to mechanical demands. This chapter gathers together some recent advances in bone physiology and molecular cell biology and discusses the potential application of the functional adaptation of bone to loading to enhance bone strength during childhood and adolescence.
authors.affiliation: Faculty of Medicine, Dentistry and Health, Academic Unit of Human Nutrition, University of Sheffield, Sheffield, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Grabowski
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D001846:Bone Development / Q000502:physiology*; D001853:Bone Marrow / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation; D015444:Exercise / Q000502:physiology; D006023:Glycoproteins / Q000378:metabolism; D006410:Hematopoiesis; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism / Q000502:physiology*; D010010:Osteoclasts / Q000378:metabolism / Q000502:physiology*; D010011:Osteocytes; D010710:Phosphates / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism; D013314:Stress, Mechanical; D016474:Weight-Bearing
chemical_list: D006023:Glycoproteins; D010710:Phosphates; D011509:Proteoglycans; D002118:Calcium