title: Effect of yogurt containing deep sea water on health-related serum parameters and intestinal microbiota in mice.
abstract: Deep sea water (DSW) has health benefits and is widely used as food supplement; however, its effect in fermented products has not been explored. Here, we investigated the effect of DSW-containing yogurt on health-related serum parameters and intestinal microbiota in mice. Animals were assigned to 3 feeding groups, which received water (control), normal yogurt (N-yogurt), or DSW-containing yogurt (DSW-yogurt) with a basal diet. Mice were killed at wk 4 or 8 of feeding and analyzed for serum parameters and microbial population in the small intestine. Both yogurt groups demonstrated increased populations of intestinal lactic acid bacteria compared with the control group. The activity of serum aspartate aminotransferase and alanine aminotransferase was markedly decreased in the DSW-yogurt and N-yogurt groups, and triglyceride level tended to be lower in the DSW-yogurt group compared with that in the control mice. Furthermore, the DSW-yogurt group showed a more significant decrease in the ratio of total cholesterol to high-density lipoprotein-cholesterol than did the N-yogurt group. These findings suggest that DSW supplementation of yogurt can increase its beneficial effects on lipid metabolism.
authors.affiliation: Animal Products Utilization Division, National Institute of Animal Science, Rural Development Administration, 1500 Kongjwipatjwi-ro, Iseo-myeon, Wanju-gun 565-851, Korea.
authors.forename: Sun Moon
authors.initials: SM
authors.lastname: Kang
authors.affiliation: Division of Applied Animal Science, College of Animal Life Sciences, Kangwon National University, KNU Ave 1, Chuncheon 200-701, Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Jhoo
authors.affiliation: Division of Applied Animal Science, College of Animal Life Sciences, Kangwon National University, KNU Ave 1, Chuncheon 200-701, Korea.
authors.forename: Jae In
authors.initials: JI
authors.lastname: Pak
authors.affiliation: Division of Applied Animal Science, College of Animal Life Sciences, Kangwon National University, KNU Ave 1, Chuncheon 200-701, Korea.
authors.forename: Ill Kyoung
authors.initials: IK
authors.lastname: Kwon
authors.affiliation: Division of Applied Animal Science, College of Animal Life Sciences, Kangwon National University, KNU Ave 1, Chuncheon 200-701, Korea.
authors.forename: Sung Ki
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Division of Applied Animal Science, College of Animal Life Sciences, Kangwon National University, KNU Ave 1, Chuncheon 200-701, Korea. Electronic address: gykim@kangwon.ac.kr.
authors.forename: Gur Yoo
authors.initials: GY
authors.lastname: Kim
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D000069196:Gastrointestinal Microbiome; D007422:Intestines / Q000382:microbiology*; D007778:Lactobacillus / Q000254:growth & development; D051379:Mice; D010376:Pediococcus / Q000254:growth & development; D012623:Seawater / Q000032:analysis*; D014280:Triglycerides / Q000097:blood; D015014:Yogurt / Q000032:analysis* / Q000382:microbiology
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: deep sea water; intestinal microbiota; serum parameter; yogurt