title: Charming neighborhoods on the cell surface: plasma membrane microdomains regulate receptor tyrosine kinase signaling.
abstract: Receptor tyrosine kinases (RTK) are an important family of growth factor and hormone receptors that regulate many aspects of cellular physiology. Ligand binding by RTKs at the plasma membrane elicits activation of many signaling intermediates. The spatial and temporal regulation of RTK signaling within cells is an important determinant of receptor signaling outcome. In particular, the compartmentalization of the plasma membrane into a number of microdomains allows context-specific control of RTK signaling. Indeed various RTKs are recruited to and enriched within specific plasma membrane microdomains under various conditions, including lipid-ordered domains such as caveolae and lipid rafts, clathrin-coated structures, tetraspanin-enriched microdomains, and actin-dependent protrusive membrane microdomains such as dorsal ruffles and invadosomes. We examine the evidence for control of RTK signaling by each of these plasma membrane microdomains, as well as molecular mechanisms for how this spatial organization controls receptor signaling.
authors.affiliation: Department of Chemistry and Biology, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada; Graduate Program in Molecular Science, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada.
authors.forename: Ralph Christian
authors.initials: RC
authors.lastname: Delos Santos
authors.affiliation: Department of Chemistry and Biology, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada; Graduate Program in Molecular Science, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada.
authors.forename: Camilo
authors.initials: C
authors.lastname: Garay
authors.affiliation: Department of Chemistry and Biology, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada; Graduate Program in Molecular Science, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada. Electronic address: cantonescu@ryerson.ca.
authors.forename: Costin N
authors.initials: CN
authors.lastname: Antonescu
mesh_terms: D000818:Animals; D021941:Caveolae / Q000201:enzymology; D022461:Caveolins / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000201:enzymology* / Q000648:ultrastructure; D021381:Protein Transport; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D022461:Caveolins; D020794:Receptor Protein-Tyrosine Kinases
keywords: Clathrin; Dorsal ruffle; Lipid rafts; Receptor signaling; Signal transduction; Spatial organization; Tetraspanin