title: Orbitofrontal cortex mediates the differential impact of signaled-reward probability on discrimination accuracy.
abstract: Orbitofrontal cortex (OFC) function is critical to decision making and behavior based on the value of expected outcomes. While some of the roles the OFC plays in value computations and behavior have been identified, the role of the OFC in modulating cognitive resources based on reward expectancy has not been explored. Here we assessed the involvement of OFC in the interaction between motivation and attention. We tested mice in a sustained-attention task in which explicitly signaling the probability of reward differentially modulates discrimination accuracy. Using pharmacogenetic methods, we generated mice in which neuronal activity in the OFC could be transiently and reversibly inhibited during performance of our signaled-probability task. We found that inhibiting OFC neuronal activity abolished the ability of reward-associated cues to differentially impact accuracy of sustained-attention performance. This failure to modulate attention occurred despite evidence that mice still processed the differential value of the reward-associated cues. These data indicate that OFC function is critical for the ability of a reward-related signal to impact other cognitive and decision-making processes and begin to delineate the neural circuitry involved in the interaction between motivation and attention.
authors.affiliation: Department of Neuroscience, Columbia University New York, NY, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Ward
authors.affiliation: Department of Neuroscience, Columbia University New York, NY, USA.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Winiger
authors.affiliation: Department of Neuroscience, Columbia University New York, NY, USA ; Howard Hughes Medical Institute Chevy Chase, MD, USA ; Kavli Institute for Brain Science, Columbia University New York, NY, USA.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Kandel
authors.affiliation: Department of Psychiatry, Columbia University New York, NY, USA ; Department of Psychology, Barnard College New York, NY, USA ; New York State Psychiatric Institute New York, NY, USA.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Balsam
authors.affiliation: Department of Psychiatry, Columbia University New York, NY, USA ; New York State Psychiatric Institute New York, NY, USA.
authors.forename: Eleanor H
authors.initials: EH
authors.lastname: Simpson
keywords: DREADD; cognition-motivation interactions; discrimination accuracy; motivation; orbitofrontal cortex; pharmacogenetic inhibition; signaled-reward probability; sustained attention