title: Formaldehyde Exposure and Mortality Risks From Acute Myeloid Leukemia and Other Lymphohematopoietic Malignancies in the US National Cancer Institute Cohort Study of Workers in Formaldehyde Industries.
abstract: OBJECTIVE
  To evaluate associations between cumulative and peak formaldehyde exposure and mortality from acute myeloid leukemia (AML) and other lymphohematopoietic malignancies.
  
  
  METHODS
  Cox proportional hazards analyses.
  
  
  RESULTS
  Acute myeloid leukemia was unrelated to cumulative exposure. Hodgkin lymphoma relative risk estimates in the highest exposure categories of cumulative and peak exposures were, respectively, 3.76 (Ptrend = 0.05) and 5.13 (Ptrend = 0.003). There were suggestive associations with peak exposure observed for chronic myeloid leukemia, albeit based on very small numbers. No other lymphohematopoietic malignancy was associated with either chronic or peak exposure.
  
  
  CONCLUSIONS
  Insofar as there is no prior epidemiologic evidence supporting associations between formaldehyde and either Hodgkin leukemia or chronic myeloid leukemia, any causal interpretations of the observed risk patterns are at most tentative. Findings from this re-analysis do not support the hypothesis that formaldehyde is a cause of AML.
authors.affiliation: From the Department of Family Medicine & Public Health (Dr Checkoway), University of California, San Diego School of Medicine, La Jolla; ENVIRON International Corporation (Mss Dell and Crawford, Drs Gallagher and Mundt), Amherst, Mass; Mount Sinai Hospital (Dr Boffetta), New York, NY; and Johns Hopkins Bloomberg School of Public Health (Dr Lees), Baltimore, Md.
authors.forename: Harvey
authors.initials: H
authors.lastname: Checkoway
authors.forename: Linda D
authors.initials: LD
authors.lastname: Dell
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Alexa E
authors.initials: AE
authors.lastname: Gallagher
authors.forename: Lori
authors.initials: L
authors.lastname: Crawford
authors.forename: Peter Sj
authors.initials: PS
authors.lastname: Lees
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Mundt
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D019337:Hematologic Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced / Q000453:epidemiology; D008297:Male; D054547:National Cancer Institute (U.S.); D009784:Occupational Diseases / Q000139:chemically induced* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D005557:Formaldehyde