title: [The effect of antianxiety and anti-depressive agents for the acid-related gastrointestinal diseases].
abstract: The first-line drug for acid-related gastrointestinal diseases is acid-suppressive agents (proton pump inhibitor(PPI), H2 receptor antagonist, etc.). However, among them, there are pathophysiological conditions that cannot be cured by acid-suppressive agents. These conditions are related to the complexity of the pathophysiology, and so called "PPI-resistant gastro-esophageal reflux disease (GERD)" is one of such conditions. In these pathophysiological conditions, hypersensitive esophagus to either acid, weakly acid and non-acid, and functional heartburn are included. Esophageal hypersensitivity is associated with psychiatric disorders and anxiety changes the esophageal sensitivity. Therefore, anti-anxiety agents might be effective. However, there has been no evidence. Hypersensitive esophagus, functional heartburn, and non-cardiac chest pain can be the candidates of the use of anti-depressive agents. The evidence of antianxiety and anti-depressive agents on PPI resistant GERD is not enough and further studies are warranted.
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Oshima
authors.forename: Hiroto
authors.initials: H
authors.lastname: Miwa
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D050782:Esophageal pH Monitoring; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D054328:Proton Pump Inhibitors