title: A novel deep photodynamic therapy modality combined with CT imaging established via X-ray stimulated silica-modified lanthanide scintillating nanoparticles.
abstract: Multifunctional LaF3:Tb scintillating nanoparticles (ScNPs) coated with homogenous layers of silica and subsequently tethered with RB covalently were elaborated. The nanoconjugates with a high colloidal stability and biocompatibility could generate a reasonable amount of (1)O2 through efficient energy transfer upon external illumination, which enables them to be potentially applied in diagnosis and photodynamic therapy for deep seated tumour.
authors.affiliation: National Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. hjun0718@163.com nanomedicine@mail.hust.edu.cn.
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Elmenoufy
authors.forename: Yong'an
authors.initials: Y
authors.lastname: Tang
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Huibi
authors.initials: H
authors.lastname: Xu
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003102:Colloids / Q000737:chemistry; D003131:Combined Modality Therapy; D004735:Energy Transfer; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000175:diagnosis / Q000188:drug therapy; D010100:Oxygen / Q000737:chemistry; D010778:Photochemotherapy; D012822:Silicon Dioxide / Q000737:chemistry*; D014057:Tomography, X-Ray Computed; D014965:X-Rays
chemical_list: D020099:Coated Materials, Biocompatible; D003102:Colloids; D028581:Lanthanoid Series Elements; D012822:Silicon Dioxide; D010100:Oxygen