title: The expression difference of insulin-like growth factor 1 receptor in breast cancers with or without diabetes.
abstract: BACKGROUND
  The insulin-like growth factor (IGF) and insulin receptors' (IR) axes play important roles in both breast cancer and diabetes mellitus.
  
  
  OBJECTIVE
  We tend to explore the expression characteristics of proteins in IGF/IR axis in breast cancer with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  We conducted a case-control investigation of T2DM and non-diabetes (n = 40, 1:1) in breast cancer patients.
  
  
  METHODS
  Some important molecules of IGF/IR axis were detected in breast cancer tissues by immunohistochemical staining. The multivariable analyses of the relationship of clinicopathological characters with the significant molecules were also detected.
  
  
  METHODS
  The results were statistically evaluated by Statistical Package for the Social Sciences (SPSS version 17.0) software. Chi-square test and logistic regression are used.
  
  
  RESULTS
  Higher expression of IGF 1 receptor (IGF1R) was found in breast cancers of patients with T2DM, compared those without diabetes (P = 0.044). Negative expression of human epidermal growth factor receptor 2 (Her2) was found to be associated with higher expression of IGF1R in the breast cancers of patients with T2DM. There were no differences found in the expression of proteins of IGF-1, IGF-2, IGF-binding protein 3 (IGFBP3), IR, insulin receptor substrate (IRS)-1, IRS-2 and mammalian target of rapamycin (mTOR) between T2DM group and non-diabetes group.
  
  
  CONCLUSIONS
  Our study found that breast cancer with T2DM had a higher expression of IGF1R, and the higher IGF1R was associated with negative Her2 expression.
authors.forename: Chen
authors.initials: C
authors.lastname: Xin
authors.forename: Ding
authors.initials: D
authors.lastname: Jing
authors.forename: Tang
authors.initials: T
authors.lastname: Jie
authors.forename: Luo
authors.initials: L
authors.lastname: Wu-Xia
authors.forename: Qiu
authors.initials: Q
authors.lastname: Meng
authors.affiliation: Department of Medical Oncology, Cancer Center, The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Ji-Yan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001943:Breast Neoplasms / Q000150:complications* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies; D015398:Signal Transduction; D047368:Tumor Burden
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1