title: Tea consumption and risk of gallbladder cancer: A meta-analysis of epidemiological studies.
abstract: Previous epidemiological studies investigating the association between tea consumption and the risk of gallbladder cancer have yielded inconsistent results. Therefore, we aimed to assess this association by conducting a meta-analysis of all available studies. A search was conducted through Pubmed, Embase, Chinese Biomedical literature Database and China Knowledge Resource Integrated Database to identify relevant studies on tea consumption and the risk of gallbladder cancer. A random-effects model was used to calculate the overall combined risk estimates. Six studies (4 case-control and 2 cohort studies), involving a total of 753 patients and 115,349 controls, were included in this meta-analysis. The overall combined odds ratio (OR) for tea consumption and gallbladder cancer was 0.67 [95% confidence interval (CI): 0.40-1.12, P=0.13]. Similar results were obtained for the high or moderate tea consumption vs. the low/non-consumption groups. However, our meta-analysis identified a significant association between tea consumption and reduced gallbladder cancer risk in women (OR=0.46, 95% CI: 0.26-0.81, P=0.008), but not in men (OR=0.43, 95% CI: 0.12-1.59, P=0.21). Therefore, the results of the present meta-analysis suggest that, according to the currently available epidemiological studies, tea consumption may reduce the risk of gallbladder cancer in women, but not in men. Further epidemiological studies are required to determine the association between tea consumption and the risk of gallbladder cancer.
authors.affiliation: Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China ; Key Laboratory of Ministry of Education for Gastrointestinal Cancer and Key Laboratory of Tumor Microbiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Guangwei
authors.initials: G
authors.lastname: Zhu
authors.affiliation: The First Clinic Medical College and The First Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Hua
authors.affiliation: The Affiliated People's Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350005, P.R. China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Key Laboratory of Ministry of Education for Gastrointestinal Cancer and Key Laboratory of Tumor Microbiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Feifei
authors.initials: F
authors.lastname: She
authors.affiliation: Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China ; Key Laboratory of Ministry of Education for Gastrointestinal Cancer and Key Laboratory of Tumor Microbiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Chen
keywords: epidemiological studies; gallbladder carcinoma; meta-analysis; tea consumption