title: miR-216a may inhibit pancreatic tumor growth by targeting JAK2.
abstract: This study was aimed to investigate miR-216a expression in pancreatic cancer and determine its effects on proliferation. miR-216a was found downregulated in pancreatic cancer tissues as compared to benign pancreatic lesions. JAK2 was identified as a miR-216a gene target. Further, in vivo treatment of PANC-1 tumors with miR-216a reduced JAK2 protein levels in the tumor and reduced tumor volume. In conclusion, miR-216a may function as a tumor suppressor regulating pancreatic cancer cells by targeting the JAK/STAT pathway. Further studies with a larger number of patient samples are necessary to fully explore the diagnostic and therapeutic potential of miR-216a for pancreatic cancer.
authors.affiliation: Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, PR China.
authors.forename: Bao-hua
authors.initials: BH
authors.lastname: Hou
authors.affiliation: Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, PR China.
authors.forename: Zhi-xiang
authors.initials: ZX
authors.lastname: Jian
authors.affiliation: Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cui
authors.affiliation: Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, PR China.
authors.forename: Shao-jie
authors.initials: SJ
authors.lastname: Li
authors.affiliation: Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, PR China.
authors.forename: Rui-qing
authors.initials: RQ
authors.lastname: Tian
authors.affiliation: Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, PR China. Electronic address: oujinrui@aliyun.com.
authors.forename: Jin-rui
authors.initials: JR
authors.lastname: Ou
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000328:Adult; D000368:Aged; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D015153:Blotting, Western; D002460:Cell Line; D045744:Cell Line, Tumor; D015536:Down-Regulation; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D047368:Tumor Burden / Q000235:genetics; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D020413:3' Untranslated Regions; C575482:MIRN216 microRNA, human; D035683:MicroRNAs; C507924:JAK2 protein, human; D053614:Janus Kinase 2
keywords: Apoptosis; Cell proliferation; JAK2; Microarray miR-216a; Pancreatic cancer