title: New ruthenium(II) coordination compounds possessing bidentate aminomethylphosphane ligands: synthesis, characterization and preliminary biological study in vitro.
abstract: Addition of aminomethylphosphane P{CH2N(CH2CH2)2O}3 (), PPh2{CH2N(CH2CH2)2O} () or PPh2{CH2N(CH2CH2)2NCH2CH3} () to a methanolic solution of RuCl3 results in reduction of ruthenium(iii) ions giving finally ttt-[RuCl2()2] (), ttt-[RuCl2()2] () and ttt-[RuCl2()2] (). The synthesized complexes are the first examples of ruthenium(ii) coordination compounds possessing aminomethylphosphanes chelating via phosphorus and nitrogen atoms. They were fully characterized (NMR, ESI-MS, IR, elemental analysis, X-ray crystallography). Preliminary studies of the in vitro cytotoxicity on the A549 cell line (human lung adenocarcinoma) and interactions with human serum proteins (albumin and apotransferrin) showed moderate activity of the complexes. Interestingly, the P,N-chelation leads to formation of strained 4-membered Ru-P-C-N-Ru rings, which in the case of and undergo opening in the presence of CH3CN, which results in rearrangement to ctc-[RuCl2()2(CH3CN)2] () and ctc-[RuCl2()2(CH3CN)2] ().
authors.affiliation: Faculty of Chemistry, Jagiellonian University in Krakow, Ingardena 3, 30-060 Krakow, Poland. kyziol@chemia.uj.edu.pl.
authors.forename: Michał
authors.initials: M
authors.lastname: Płotek
authors.forename: Radosław
authors.initials: R
authors.lastname: Starosta
authors.forename: Urszula K
authors.initials: UK
authors.lastname: Komarnicka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Skórska-Stania
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jeżowska-Bojczuk
authors.forename: Grażyna
authors.initials: G
authors.lastname: Stochel
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kyzioł
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001059:Apoproteins / Q000378:metabolism; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D010087:Oxides / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D012709:Serum Albumin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001059:Apoproteins; D056831:Coordination Complexes; D008024:Ligands; D010087:Oxides; D010720:Phosphines; D012709:Serum Albumin; D014168:Transferrin; C028284:apotransferrin; D012428:Ruthenium; C044646:phosphine