title: Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides.
abstract: A series of novel phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides were synthesized by condensation of sulfonamides with heterocyclic methyl carbimidates obtained from heterocyclic carbonitriles and used 'at its inception.' The molecular structure of the obtained compounds is discussed. Compounds possessing heterocyclic systems with a nitrogen atom in the α position to the functional group showed a different single-crystal structure than expected. The synthesized derivatives were evaluated for antimicrobial activities: tuberculostatic, antibacterial, and antifungal.
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authors.affiliation: Department of Organic Chemistry, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Gobis
authors.affiliation: Department of Organic Chemistry, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Henryk
authors.initials: H
authors.lastname: Foks
authors.affiliation: Department of Medicinal Microbiology, Chair of Microbiology, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Wiśniewska
authors.affiliation: Department of Medicinal Microbiology, Chair of Microbiology, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Dąbrowska-Szponar
authors.affiliation: Department of Microbiology, Institute of Tuberculosis and Pulmonary Diseases, Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Augustynowicz-Kopeć
authors.affiliation: Department of Microbiology, Institute of Tuberculosis and Pulmonary Diseases, Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Napiórkowska
authors.affiliation: Department of Physical Chemistry, University of Gdańsk, Gdańsk, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Sikorski
keywords: Antimicrobial activity; Crystal structure; Heterocycles; Structure–activity relationship; Sulfonamidine; Synthesis