title: Reliability of oscillometric central hemodynamic responses to an orthostatic challenge.
abstract: BACKGROUND
  Monitoring central hemodynamic responses to an orthostatic challenge may provide important insight into autonomic nervous system function. Oscillometric pulse wave analysis devices have recently emerged, presenting clinically viable options for investigating central hemodynamic properties. The purpose of the current study was to determine whether oscillometric pulse wave analysis can be used to reliably (between-day) assess central blood pressure and central pressure augmentation (augmentation index) responses to a 5 min orthostatic challenge (modified tilt-table).
  
  
  METHODS
  Twenty healthy adults (26.4 y (SD 5.2), 55% F, 24.7 kg/m(2) (SD 3.8)) were tested on 3 different mornings in the fasted state, separated by a maximum of 7 days. Central hemodynamic variables were assessed on the left arm using an oscillometric device.
  
  
  RESULTS
  Repeated measures analysis of variance indicated a significant main effect of the modified tilt-table for all central hemodynamic variables (P < 0.001). In response to the tilt, central diastolic pressure increased by 4.5 mmHg (CI: 2.6, 6.4), central systolic blood pressure increased by 2.3 (CI: 4.4, 0.16) mmHg, and augmentation index decreased by an absolute - 5.3%, (CI: -2.7, -7.9%). The intra-class correlation coefficient values for central diastolic pressure (0.83-0.86), central systolic blood pressure (0.80-0.87) and AIx (0.79-0.82) were above the 0.75 criterion in both the supine and tilted positions, indicating excellent between-day reliability.
  
  
  CONCLUSIONS
  Central hemodynamic responses to an orthostatic challenge can be assessed with acceptable between-day reliability using oscillometric pulse wave analysis.
authors.affiliation: School of Sport and Exercise, Massey University, Wellington, Private Bag 756, Wellington, 6140, New Zealand. Electronic address: l.stoner@massey.ac.nz.
authors.forename: Lee
authors.initials: L
authors.lastname: Stoner
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, USA.
authors.forename: Chantel
authors.initials: C
authors.lastname: Bonner
authors.affiliation: School of Human Performance and Recreation, University of Southern Mississippi, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Credeur
authors.affiliation: Faculty of Health Sciences, University of Southampton, Hants, UK.
authors.forename: Danielle
authors.initials: D
authors.lastname: Lambrick
authors.affiliation: Department of Sport & Exercise, University of Winchester, UK.
authors.forename: James
authors.initials: J
authors.lastname: Faulkner
authors.affiliation: School of Sport and Exercise, Massey University, Wellington, Private Bag 756, Wellington, 6140, New Zealand.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wadsworth
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Williams
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000592:standards*; D015331:Cohort Studies; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D009991:Oscillometry / Q000379:methods*; D011187:Posture; D063177:Pulse Wave Analysis; D015203:Reproducibility of Results; D055815:Young Adult
keywords: Arterial wave reflection; Augmentation index; Central blood pressure; Orthostatic challenge; Pulse wave analysis