title: Mycobacterial spindle cell pseudotumour of the brain in a patient with sarcoidosis.
abstract: Mycobacterial spindle cell pseudotumours (MSP) are benign lesions characterised by local proliferation of spindle-shaped histiocytes caused by mycobacterial infections. Cerebral MSP due to Mycobacterium avium intracellulare (MAI) infection is rare, and is often misdiagnosed clinically and radiologically as a brain tumour. We present a case with underlying sarcoidosis and known pulmonary MAI infection presenting with partial seizures and headaches. Imaging of the brain revealed a solitary extra axial tumour within the right temporal area. Biopsy of the tumour showed evidence of MPS due to MAI infection. Prolonged treatment with antituberculous therapy showed complete resolution of the cerebral lesion.
authors.affiliation: Department of Respiratory Medicine, Heart of England NHS Foundation Trust, Sutton Coldfield, West Midlands, UK.
authors.forename: Iyad
authors.initials: I
authors.lastname: Ismail
authors.affiliation: Department of Pathology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, West Midlands, UK.
authors.forename: Martyn
authors.initials: M
authors.lastname: Carey
authors.affiliation: Department of Pathology, Heart of England NHS Foundation Trust, Birmingham, West Midlands, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Trotter
authors.affiliation: Department of Respiratory Medicine, Queen Mary University Hospital, London, London, UK.
authors.forename: Heinke
authors.initials: H
authors.lastname: Kunst
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000175:diagnosis* / Q000188:drug therapy; D001932:Brain Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D020773:Headache Disorders / Q000382:microbiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis* / Q000188:drug therapy; D012507:Sarcoidosis / Q000150:complications*; D012509:Sarcoma / Q000175:diagnosis; D012640:Seizures / Q000382:microbiology; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents