title: [Effect of 18-β Glycyrrhetinic Acid on the Endoplasmic Reticulum of Nasal Epithelial Cells in Allergic Rhinitis Model Rats].
abstract: OBJECTIVE
  To explore the effect of 18-β glycyrrhetinic acid (GA) on the endoplasmic reticulum of nasal epithelial cells in allergic rhinitis (AR) model rats.
  
  
  METHODS
  Totally 96 Wistar rats were randomly divided into the blank group, the AR model group, the loratadine group, the GA group, 24 in each group. AR models were established by peritoneally injecting ovalbumin (OVA). Morphological scoring was performed. GA at 21. 6 mg/kg was intragastrically administered to rats in the GA group. Nasal mucosal tissues were taken for electron microscopic examinations at the second, fourth, sixth, and tenth week after drug intervention.
  
  
  RESULTS
  The overlapping score was 2.10 ± 0.45 in the blank group, 5.10 ± 0.56 in the loratadine group, 5.10 ± 0.56 in the AR model group, 5.20 ± 0.78 in the GA group, showing statistical difference when compared with the blank group (P < 0.01). Results under transmission electron microscope showed that the number of the endoplasmic reticulum increased in the AR model group, with obvious cystic dilatation, a lot of vacuole formation, and degranulation. A large number of free ribosomes could be seen in cytoplasm. With persistent allergen exposure, changes mentioned above was progressively aggravated in the endoplasmic reticulum of nasal mucosal epithelium in the AR model group. But the dilation of endoplasmic reticulum, vacuole formation, and degranulation were relieved in the GA group, and got close to those of the blank group.
  
  
  CONCLUSIONS
  18-β GA could improve the expansion, vacuolization, and degranulation of the endoplasmic reticulum of nasal epithelial cells in AR model rats.
authors.forename: Gui-jun
authors.initials: GJ
authors.lastname: Yang
authors.forename: Ke-hu
authors.initials: KH
authors.lastname: Xi
authors.forename: Xiao-wan
authors.initials: XW
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Gui
authors.forename: You-hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Fu-hong
authors.initials: FH
authors.lastname: Zhang
authors.forename: Chun-xia
authors.initials: CX
authors.lastname: Ma
authors.forename: Hao
authors.initials: H
authors.lastname: Hong
authors.forename: Xiang-yi
authors.initials: XY
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Ma
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Ming
authors.initials: M
authors.lastname: Dong
authors.forename: Xiao-bing
authors.initials: XB
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004721:Endoplasmic Reticulum; D004847:Epithelial Cells / Q000187:drug effects; D006034:Glycyrrhetinic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D009297:Nasal Mucosa / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D065631:Rhinitis, Allergic / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D006034:Glycyrrhetinic Acid