title: Sarcopenia and body composition in diabetic Charcot osteoarthropathy.
abstract: BACKGROUND
  Treatment of Charcot osteoarthropathy (COA) requires restricted walking and offloading for several months, which lead to fat re-distribution and increased sarcopenia.
  
  
  OBJECTIVE
  To investigate whether subjects with COA have an altered body composition compared to controls.
  
  
  METHODS
  Cross-sectional case-control study of people with diabetes with acute or chronic Charcot osteoarthropathy, matched with otherwise healthy people with diabetes. A total of 49 subjects (distribution ~1:1) had a total body DXA-scanning, measuring appendicular lean mass, android/gynoid and truncal/total body fat distribution ratios.
  
  
  RESULTS
  Sarcopenia frequency was higher in the total population with diabetes overall (9-40%), compared to normal materials. Using two different models for correlating appendicular lean mass to sarcopenia, there were no differences in sarcopenia-rates between the groups (P=0.413 and 0.948 respectively). There was no significant difference in lean tissue mass between the affected and the unaffected leg in the immobilised subject group (P=0.830). The average fat percentage was (29.4-37.7%) in the population with diabetes, compared to a matching background population (24.5-31.9%), whereas there were no significant differences found between the groups (P=0.065). Neither truncal/total fat percent nor android/gynoid fat percent ratios showed differences between the groups.
  
  
  CONCLUSIONS
  To our knowledge, this is the first published dataset investigating body composition in subjects with Charcot osteoarthropathy. The study population of diabetics were more fat and sarcopenic than normal subjects, whereas no statistically significant impact of Charcot osteoarthropathy was found.
authors.affiliation: Department of Endocrinology, Bispebjerg Hospital, University of Copenhagen, DK-2400 Copenhagen NV, Denmark. Electronic address: Rasmus.Bo.Jansen@regionh.dk.
authors.forename: Rasmus Bo
authors.initials: RB
authors.lastname: Jansen
authors.affiliation: Department of Endocrinology, Bispebjerg Hospital, University of Copenhagen, DK-2400 Copenhagen NV, Denmark.
authors.forename: Tomas Møller
authors.initials: TM
authors.lastname: Christensen
authors.affiliation: Department of Clinical Physiology and Imaging, Bispebjerg Hospital, University of Copenhagen, DK-2400 Copenhagen NV, Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Bülow
authors.affiliation: Department of Clinical Physiology and Imaging, Bispebjerg Hospital, University of Copenhagen, DK-2400 Copenhagen NV, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Rørdam
authors.affiliation: Copenhagen Center for Wound Healing, Bispebjerg Hospital, University of Copenhagen, DK-2400 Copenhagen NV, Denmark.
authors.forename: Per E
authors.initials: PE
authors.lastname: Holstein
authors.affiliation: Department of Endocrinology, Bispebjerg Hospital, University of Copenhagen, DK-2400 Copenhagen NV, Denmark.
authors.forename: Ole Lander
authors.initials: OL
authors.lastname: Svendsen
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis; D000704:Analysis of Variance; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000453:epidemiology* / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012016:Reference Values; D055948:Sarcopenia / Q000175:diagnosis* / Q000453:epidemiology*; D012720:Severity of Illness Index; D017678:Sex Distribution
keywords: Appendicular lean mass; Body composition; Charcot osteoarthropathy; Diabetes mellitus; Sarcopenia