title: Hepatoid adenocarcinoma of the stomach: A case report and review of the literature.
abstract: Hepatoid adenocarcinoma is a rare tumor, associated with an extremely poor prognosis. In the present report, a 72-year-old female presented to Huashan Hospital (Shanghai, China) with upper abdominal discomfort and, following endoscopy, an ulcerated lesion was observed in the stomach. A computed tomography scan revealed a mass in the antrum of the stomach and the α-fetoprotein level was normal. Sections of the mass exhibited malignant cells arranged in a solid to trabecular pattern; the cells were polygonal shaped with well-defined cytoplasmic borders. Immunohistochemical analysis was performed and the cells were positive for Hep1, CK, CK8, CK18 and P53. The histological features together with the immunohistochemical findings were diagnostic of a hepatoid adenocarcinoma of the stomach. Immunohistochemical studies may aid in the identification of the characteristic features and prevent the misdiagnosis of this tumor.
authors.affiliation: Department of General Surgery, Luwan Branch, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200020, P.R. China.
authors.forename: R U
authors.initials: RU
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Yantao
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Y I
authors.initials: YI
authors.lastname: Yang
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Zongyou
authors.initials: Z
authors.lastname: Chen
keywords: gastric adenocarcinoma; hepatoid adenocarcinoma; immunohistochemistry