title: Malignant Solitary Fibrous Tumor of the Pancreas.
abstract: Solitary fibrous tumor (SFT) arising in the pancreas is exceedingly rare, with only 11 cases reported in the English literature. All cases described thus far have exhibited benign histology. We report the first case of malignant SFT of the pancreas. The patient was a 52-year-old woman who presented with obstructive jaundice and a 15-cm pancreatic head mass. The mass showed areas with typical histologic features for SFT including small fibroblastlike cells arranged in the well-characterized "patternless pattern" of architecture, hemangiopericytomalike vessels, areas with dense collagen and infrequent mitoses (0-2 per 10 high-power fields [HPFs]). In addition, multiple areas with an overtly sarcomatous morphology were present, containing large spindle and epithelioid cells with nuclear pleomorphism, marked cellularity, up to17 mitoses per 10 HPFs, and necrosis. Immunohistochemical stains were positive for CD34 and B-cell CLL/lymphoma 2 (Bcl-2) in both benign and malignant components and showed strong, diffuse p53 and p16 staining in the malignant component. At last follow-up (40 months), the patient was alive and well without evidence of disease. However, given that the presence of a malignant component in extrapancreatic SFT has been associated with recurrence/metastasis and death, complete surgical resection and close long-term follow-up is required.
authors.affiliation: From the Departments of *Pathology, and †Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX.
authors.forename: Jeannelyn S
authors.initials: JS
authors.lastname: Estrella
authors.forename: Huamin
authors.initials: H
authors.lastname: Wang
authors.forename: Priya R
authors.initials: PR
authors.lastname: Bhosale
authors.forename: Harry L
authors.initials: HL
authors.lastname: Evans
authors.forename: Susan C
authors.initials: SC
authors.lastname: Abraham
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation; D002763:Cholecystectomy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D008940:Mitotic Index; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016577:Pancreaticoduodenectomy; D054364:Solitary Fibrous Tumors / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor