title: Efficacy of different irrigation solutions on the early debridement of open fracture in rats.
abstract: Contaminating bacteria are only found on wound surfaces in the initial stages of open fractures; therefore, effective debridement is critical for bacterial infection prevention and the reduction of inflammatory reactions. Various irrigation solutions are currently being used; however, a comprehensive study on their efficacy is lacking. In the present study, a comparison of the effects of normal saline, iodophor and hydrogen peroxide as the irrigation solutions for debridement of open femur fractures in rat models was conducted. It was revealed that all three solutions were comparably effective in bacterial removal while normal saline was superior in minimizing adverse wound inflammation; therefore, the use of normal saline for routine debridement is recommended in the early-stage treatment of open fractures in the trauma clinic and in relief fieldwork.
authors.affiliation: Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Department of Obstetrics and Gynecology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China.
authors.forename: Dong-Hua
authors.initials: DH
authors.lastname: DI
authors.affiliation: Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China.
authors.forename: Guo-Yang
authors.initials: GY
authors.lastname: Zhao
authors.affiliation: Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China.
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Cui
keywords: debridement; irrigation solution; open fractures