title: Bioengineering methods for myocardial regeneration.
abstract: The challenging task of heart regeneration is being pursued in three related directions: derivation of cardiomyocytes from human stem cells, in vitro engineering and maturation of cardiac tissues, and development of methods for controllable cell delivery into the heart. In this review, we focus on tissue engineering methods that recapitulate biophysical signaling found during normal heart development and maturation. We discuss the use of scaffold-bioreactor systems for engineering functional human cardiac tissues, and the methods for delivering stem cells, cardiomyocytes and engineered tissues into the heart.
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY, United States.
authors.forename: Hesam
authors.initials: H
authors.lastname: Parsa
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY, United States.
authors.forename: Kacey
authors.initials: K
authors.lastname: Ronaldson
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY, United States; Department of Medicine, Columbia University, New York, NY, United States. Electronic address: gv2131@columbia.edu.
authors.forename: Gordana
authors.initials: G
authors.lastname: Vunjak-Novakovic
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D055592:Biophysical Phenomena; D019149:Bioreactors; D002454:Cell Differentiation; D055724:Electrophysiological Phenomena; D006321:Heart / Q000502:physiology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology*; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
keywords: Bioreactor; Cardiomyocyte; Cell and tissue delivery to the heart; Electro-mechanical stimulation; Human induced pluripotent stem cells; Tissue engineering