title: Effect of Atorvastatin on Serum Levels of Total Cholesterol and High-Sensitivity C-reactive Protein in High-Risk Patients with Atrial Fibrillation in Asia.
abstract: OBJECTIVE
  The aim of this meta-analysis was to investigate the effects of atorvastatin on serum levels of high-sensitivity C-reactive protein (hs-CRP) and total cholesterol in atrial fibrillation (AF) patients in Asia.
  
  
  METHODS
  By searching English and Chinese language-based electronic databases (ie, PubMed, EBSCO, Ovid, SpringerLink, Wiley, Web of Science, Wanfang database, China National Knowledge Infrastructure, and VIP database), we identified 13 studies relevant to our topic of interest. Data were collected from the 13 studies and analyzed with Comprehensive Meta-Analysis software (version 2.0, Biostat Inc., Englewood, New Jersey).
  
  
  RESULTS
  Initially, our database searches retrieved 356 studies (45 in English, 311 in Chinese). Thirteen studies were selected for the meta-analysis following stringent criteria. The data included 1239 patients with AF, of whom 634 were treated with atorvastatin and included in the treatment group, and 605 patients were treated with conventional treatment and included in the control group. The results of our meta-analysis suggested that the serum levels of hs-CRP (mg/L) and total cholesterol (mmol/L) in the treatment group were significantly lower than those of the control group (hs-CRP: standardized mean difference = 0.962; 95% CI, 0.629-1.295, P < 0.001; total cholesterol: standardized mean difference = 1.400; 95% CI, 0.653-2.146, P < 0.001).
  
  
  CONCLUSIONS
  The findings of this study suggest that atorvastatin may be very effective in decreasing serum levels of hs-CRP and total cholesterol to prevent cardiovascular events.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China.
authors.forename: Ming Yu
authors.initials: MY
authors.lastname: Shi
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China.
authors.forename: Feng Hua
authors.initials: FH
authors.lastname: Xue
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China.
authors.forename: Shi Chao
authors.initials: SC
authors.lastname: Teng
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yin
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China. Electronic address: guhongyue218@126.com.
authors.forename: Hong Yue
authors.initials: HY
authors.lastname: Gu
mesh_terms: D000069059:Atorvastatin / Q000494:pharmacology* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000097:blood* / Q000188:drug therapy; D002097:C-Reactive Protein / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D006538:Heptanoic Acids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D011758:Pyrroles / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D002097:C-Reactive Protein; D002784:Cholesterol; D000069059:Atorvastatin
keywords: atorvastatin; atrial fibrillation; high-sensitivity C-reactive protein; meta-analysis; serum level; total cholesterol