title: RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms' Tumor in Chinese Children.
abstract: BACKGROUND
  Wilms' tumor (WT) is the most common malignant renal tumor in children. Previous studies suggested the reversion-inducing, cysteine-rich protein with Kazal motifs (RECK) down-regulation might have a role in numerous human cancers. The current study was done to investigate the associations of RECK single-nucleotide polymorphisms (SNPs) with the WT susceptibility in Chinese children.
  
  
  METHODS
  We analyzed 2 SNPs (rs10972727 and rs11788747) in a total of 97 WT children and 194 healthy matched controls (1:2 ratio) by real-time PCR and PCR-RFLP genotyping analysis.
  
  
  RESULTS
  We found that the G allele of rs11788747 in the RECK gene was significantly associated with WT in Chinese children (OR=0.7, 95% CI: 0.45-0.99; P=0.042); as with another SNP rs10972727, however, no statistically significant difference was detected. Further analysis showed there was also a statistically significant difference in genotype frequencies between terminal tumor stage (P=0.026) and metastatic groups (P=0.002).
  
  
  CONCLUSIONS
  The present data indicate that there is a significant association between mutant G of rs11788747 in RECK and WT risk. G carriers with advanced tumor stage or with metastasis might have an increased risk of WT.
authors.affiliation: Department of Pediatric Surgery, Jinan Children's Hospital, Jinan, Shandong, China (mainland).
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Pediatric Surgery, Jinan Children's Hospital, Jinan, Shandong, China (mainland).
authors.forename: Yuanjun
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Pediatric Surgery, Jinan Children's Hospital, Jinan, Shandong, China (mainland).
authors.forename: Kaisheng
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Pediatric Surgery, Jinan Children's Hospital, Jinan, Shandong, China (mainland).
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Pediatric Surgery, Jinan Children's Hospital, Jinan, Shandong, China (mainland).
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pediatric Surgery, Jinan Children's Hospital, Jinan, Shandong, China (mainland).
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D009396:Wilms Tumor / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology
chemical_list: D058851:GPI-Linked Proteins; C115460:RECK protein, human