title: Selected Inflammatory and Metabolic Markers in Psoriatic Patients Treated with Goeckerman Therapy.
abstract: Psoriasis is associated with metabolic activity of adipose tissue which produces pro- and anti-inflammatory adipokines. Goeckerman therapy (GT) represents an effective treatment of psoriasis. This study evaluated variation of selected inflammatory and metabolic markers during GT and the relationships between the markers, severity of the disease (PASI score), body mass, and the basic characteristics of the therapy. The study was conducted on a group of patients (n = 32) and on a control group (n = 24). Before GT, we found significantly elevated levels of proinflammatory CRP (p < 0.001) and leptin (p < 0.05) in psoriatic patients (compared to the controls). The therapy significantly decreased the levels of CRP and adiponectin. We found positive correlations between CRP and total duration of GT (p < 0.05) and CRP and the time of UV exposure (p < 0.01) and negative correlations between adiponectin and the total duration of GT (p < 0.05) and adiponectin and the application of CCT ointment (p < 0.001). From our results, we can conclude that GT causes partial reduction of both proinflammatory and anti-inflammatory markers. However, the levels of proinflammatory CRP and leptin remained significantly higher in the patients than in the control group.
authors.affiliation: Institute of Clinical Immunology and Allergology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Kondelkova
authors.affiliation: Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Borska
authors.affiliation: Institute of Clinical Immunology and Allergology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrys
authors.affiliation: Institute of Clinical Immunology and Allergology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Krejsek
authors.affiliation: Department of Dermatology and Venereal Diseases, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Kvetoslava
authors.initials: K
authors.lastname: Hamakova
authors.affiliation: Department of Dermatology and Venereal Diseases, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Simona
authors.initials: S
authors.lastname: Rendarova
authors.affiliation: Department of Transfusion Medicine, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Vit
authors.initials: V
authors.lastname: Rehacek
authors.affiliation: Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Kremlacek
authors.affiliation: Institute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Fiala
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*; D012720:Severity of Illness Index
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D009824:Ointments; D002097:C-Reactive Protein