title: [Two Cases of Primary Intracranial Solitary Fibrous Tumor:Genetic Examination ofNAB2-STAT6Fusion and Its Association with Hemangiopericytoma].
abstract: Using whole exome and transcriptome sequencing, NAB2-STAT6 gene fusions have recently been identified in patients with solitary fibrous tumors (SFT). We report two cases of SFT in which NAB2-STAT6 fusions were identified. The patients were a 32-year-old man with a parasagittal tumor involving the superior sagittal sinus, and a 40-year-old man with a cerebellar convexity tumor partially involving the transverse sinus. Their tumors were gross totally resected and diagnosed to be SFT according to the following pathological findings:the tumors were composed of spindle cells with a patternless architecture, with prominent stromal collagen and staghorn vessels. An immunohistochemical study yielded positive results for CD34, CD99, and Bcl-2 and negative results for EMA, GFAP, and S100. The MIB-1 indexes were 13 and 7%, respectively. NAB2-STAT6 fusions were detected in both cases with a common fusion variant, NAB2ex6-STAT6ex16/17. We also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17. These findings suggest that solitary fibrous tumor and hemangiopericytoma may be diagnosed based on the presence of NAB2-STAT6 fusion, and not classified separately because of the same genetic background.
authors.affiliation: Department of Neurosurgery, Tokyo Women's Medical University Medical Center East.
authors.forename: Asami
authors.initials: A
authors.lastname: Kikuchi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fujita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Suguru
authors.initials: S
authors.lastname: Yokosako
authors.forename: Chika
authors.initials: C
authors.lastname: Yoshimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Akagawa
authors.forename: Mariko
authors.initials: M
authors.lastname: Fujibayashi
authors.forename: Osami
authors.initials: O
authors.lastname: Kubo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Onda
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kasuya
mesh_terms: D000328:Adult; D001483:Base Sequence; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005091:Exons; D015972:Gene Expression Regulation, Neoplastic; D006393:Hemangiopericytoma / Q000235:genetics* / Q000601:surgery; D006801:Humans; D007438:Introns; D008297:Male; D011994:Recombinant Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics*; D050800:STAT6 Transcription Factor / Q000235:genetics*; D054364:Solitary Fibrous Tumors / Q000235:genetics* / Q000601:surgery
chemical_list: C491000:NAB2 protein, human; D011994:Recombinant Proteins; D012097:Repressor Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human