title: Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives.
abstract: This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry.
authors.affiliation: Department of Organic Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş street, RO-400012 Cluj-Napoca, Romania. hapau.denisa@umfcluj.ro.
authors.forename: Denisa
authors.initials: D
authors.lastname: Leonte
authors.affiliation: Department of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, Romania. cslbencze@chem.ubbcluj.ro.
authors.forename: László Csaba
authors.initials: LC
authors.lastname: Bencze
authors.affiliation: Department of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, Romania. paizs@chem.ubbcluj.ro.
authors.forename: Csaba
authors.initials: C
authors.lastname: Paizs
authors.affiliation: Department of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, Romania. irimie@chem.ubbcluj.ro.
authors.forename: Florin Dan
authors.initials: FD
authors.lastname: Irimie
authors.affiliation: Department of Organic Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş street, RO-400012 Cluj-Napoca, Romania. vzaharia@umfcluj.ro.
authors.forename: Valentin
authors.initials: V
authors.lastname: Zaharia
mesh_terms: D066241:Carbon-13 Magnetic Resonance Spectroscopy; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008352:Mannich Bases / Q000138:chemical synthesis*; D013058:Mass Spectrometry; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D006571:Heterocyclic Compounds; D008352:Mannich Bases
keywords: Mannich reaction; biocatalytic promiscuity; heterocyclic compounds; lipase