title: Proceedings: Moving Toward Cell-Based Therapies for Heart Disease.
abstract: Heart disease due to myocardial infarction and the ensuing heart failure represent a major unmet medical need. Approved treatments do not prevent loss of cardiac muscle or reduce scar formation, both of which weaken heart function. Cell-based therapies currently being investigated both preclinically and clinically have the potential to address these underlying problems either by actually replacing lost tissue or by supplying paracrine growth factors that may have multiple beneficial effects such as reduction of inflammation, increase of blood supply, improvement in cell survival, and reduction of scar size. The best cell types, stage of disease to target, and delivery method to improve heart function are currently unclear. The California Institute for Regenerative Medicine supports multiple different cell-therapy strategies for heart disease, offering hope that improved treatments will be available for patients in the future.
authors.affiliation: California Institute for Regenerative Medicine, San Francisco, California, USA lcollins@cirm.ca.gov.
authors.forename: Lila R
authors.initials: LR
authors.lastname: Collins
authors.affiliation: California Institute for Regenerative Medicine, San Francisco, California, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Priest
authors.affiliation: California Institute for Regenerative Medicine, San Francisco, California, USA.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Caras
authors.affiliation: California Institute for Regenerative Medicine, San Francisco, California, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Littman
authors.affiliation: California Institute for Regenerative Medicine, San Francisco, California, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Kadyk
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D006333:Heart Failure / Q000628:therapy; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation / Q000639:trends*