title: Comparative Study of Intragastric Balloon and Cognitive-Behavioral Approach for Non-Morbid Obesity.
abstract: OBJECTIVE
  Intragastric balloon (IGB) and cognitive-behavioral therapy (CBT) are possible options for weight reduction. The aim of our study was to compare their effectivness in inducing weight loss and metabolic changes accompanying weight loss in non-morbidly obese patients.
  
  
  METHODS
  Subjects were required to be between 18 and 55 years old and to have a BMI between 30 and 45 to be eligible. Exclusion criteria, besides those for IGB placement, were the presence of diabetes, depression, binge-eating disorder and the use of medications that affect body weight. Anthropometric, biochemical and blood pressure measurements were performed at baseline and after 6 months. A total of 114 subjects were recruited to the study and assigned to IGB (n = 60) or CBT group (n = 54). All patients completed the study.
  
  
  RESULTS
  After 6 months, patients treated with IGB lost significantly (P < 0.01) more weight (%EWL = 44.6 ± 23.9) than patients who participated in CBT (%EWL = 24.3 ± 16.0). In IGB group 75% of patients achieved ≥ 10% loss of initial weight, and 42.6% of patients in CBT group respectively. A significant improvement in all indices of metabolic syndrome except HDL cholesterol was seen in both treatment groups but much more in subjects treated with IGB.
  
  
  CONCLUSIONS
  Our results confirmed that intragastric balloon is useful method for promoting weight loss. Due to improvement of metabolic parameters and substantial benefit on liver function, obese people with metabolic syndrome appear to be the best candidates for IGB placement. Combining intragastric balloon treatment with cognitive-behavioral approach might prove valuable for even greater weight loss.
authors.forename: Sanja Klobucar
authors.initials: SK
authors.lastname: Majanovic
authors.forename: Alen
authors.initials: A
authors.lastname: Ruzic
authors.forename: Alessandra Pokrajac
authors.initials: AP
authors.lastname: Bulian
authors.forename: Vanja
authors.initials: V
authors.lastname: Licul
authors.forename: Zeljka Crncevic
authors.initials: ZC
authors.lastname: Orlic
authors.forename: Davor
authors.initials: D
authors.lastname: Stimac
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015928:Cognitive Behavioral Therapy; D017523:Croatia; D004435:Eating; D005247:Feeding Behavior; D005260:Female; D015905:Gastric Balloon; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss; D055815:Young Adult
chemical_list: D015415:Biomarkers