title: Matrix metalloproteinase-1 expression in breast cancer and cancer-adjacent tissues by immunohistochemical staining.
abstract: Although matrix metalloproteinase-1 (MMP-1) has been considered a factor of crucial importance for breast cancer cells invasion and metastasis, the expression of MMP-1 in different breast cancer and cancer-adjacent tissues have not been fully examined. In the present study, immunohistochemical staining was used to detect the MMP-1 expression in non-specific invasive ductal carcinoma of the breast, cancer-adjacent normal breast tissue, lymph node metastatic non-specific invasive ductal carcinoma of the breast and normal lymph node tissue. The results showed that MMP-1 expression is different in the above tissues. MMP-1 had a positive expression in normal lymph node tissue and lymph node metastatic non-specific invasive ductal carcinoma. The MMP-1 negative expression rate was only 6.1% in non-specific invasive ductal carcinoma of the breast and 2.9% in cancer-adjacent normal breast tissue respectively. MMP-1 expression is higher in non-specific invasive ductal carcinoma and lymph node metastatic non-specific invasive ductal carcinoma compared to cancer-adjacent normal breast tissue and normal lymph node tissue. In conclusion, higher expression of MMP-1 in breast cancer may play a crucial role in promoting breast cancer metastasis.
authors.affiliation: College of Life Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Xuan
authors.affiliation: Department of Life Sciences, Tangshan Normal University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Psycology, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Xiujun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Life Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Hu
keywords: breast; immunohistochemical staining; matrix metalloproteinase-1