title: Toxicity test of a dental commercial composite.
abstract: BACKGROUND
  International rules must be followed for testing biosecurity in dental materials. A new brand of restorative material appeared in the market and regulations indicated that it should be tested for toxicity.
  
  
  OBJECTIVE
  The aim of this study was to determine the 90-day sub chronic toxicity of one triethylene glycol dimethacrylate containing composite (MEDENTAL Light-Cure Composite™) orally administered to rats according to Organization for Economic Co-Operation and Development no. 48 guidelines and the requirements specified in the ISO 10993-11.
  
  
  METHODS
  Wistar rats ate the polymerized composite during 90 days and were observed to determine changes in their behavior, eye and skin signs and other attitudes such as aggressiveness, posture, walking and response to handling. After 90 days were sacrificed to ascertain blood alterations, we did special hematological tests and assessed microscopic slides from 33 different organs.
  
  
  RESULTS
  We recorded no significant changes in clinical behavior of the animals. Microscopic review of the H&E stained slides obtained from the analyzed organs showed no abnormal inflammatory or cytological changes and all hematological special tests were within normal limits.
  
  
  CONCLUSIONS
  Results of this study show that under our experimental conditions the MEDENTAL Light-Cure Composite™ does not produce inflammatory or cytological changes suggestive of toxicity. Key words:Dental materials, composite resin, toxicity, inflammation, TEGDMA.
authors.affiliation: Oral Pathology Laboratory. División de Estudios de Posgrado e Investigación. Facultad de Odontología, Universidad Nacional Autónoma de México. México, Distrito Federal. MÉXICO.
authors.forename: Santa
authors.initials: S
authors.lastname: Ponce-Bravo
authors.affiliation: Oral Pathology Laboratory. División de Estudios de Posgrado e Investigación. Facultad de Odontología, Universidad Nacional Autónoma de México. México, Distrito Federal. MÉXICO.
authors.forename: Constantino
authors.initials: C
authors.lastname: Ledesma-Montes
authors.affiliation: Oral Pathology Laboratory. División de Estudios de Posgrado e Investigación. Facultad de Odontología, Universidad Nacional Autónoma de México. México, Distrito Federal. MÉXICO.
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Martínez-Rivera
authors.affiliation: Oral Pathology Laboratory. División de Estudios de Posgrado e Investigación. Facultad de Odontología, Universidad Nacional Autónoma de México. México, Distrito Federal. MÉXICO.
authors.forename: Maricela
authors.initials: M
authors.lastname: Garcés-Ortíz