title: Association between Serum Fructosamine and Kidney Function in Nondiabetic Individuals without Chronic Kidney Disease.
abstract: BACKGROUND
  Serum fructosamine (SF) has been considered to be an indicator that estimates glycemic control in patients with diabetes mellitus (DM). There is increasing evidence that SF concentration and oxidative stress are significantly elevated in patients with chronic kidney disease (CKD). However, the data about SF and its association with kidney function are lacking in nondiabetic individuals without CKD. We included 1891 nondiabetic individuals who had not been diagnosed with CKD to determine the association between SF and kidney function.
  
  
  METHODS
  We conducted a retrospective analysis on the basis of the biochemistry database in nondiabetic individuals without CKD.
  
  
  RESULTS
  When eligible participants were stratified in accordance with SF quartiles, from the bottom to the top quartile of SF, a significant decrease of estimated glomerular filtration rate (GFR) was observed in baseline data. SF concentration was negatively associated with estimated GFR (r=-0.066, P=0.004) in the Pearson correlation analysis. Estimated GFR was associated with SF levels independently of glucose (GLU), total cholesterol (TC), triglyceride (TG), and total protein (TP) in multivariable logistic regression analysis (OR=0.984; CI 95% 0.977-0.991; P<0.001).
  
  
  CONCLUSIONS
  We suggest that mild elevation of SF concentration is associated with estimated GFR in nondiabetic individuals without CKD. These findings indicate that SF may underlie CKD in nondiabetic individuals.
authors.affiliation: Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: You-Fan
authors.initials: YF
authors.lastname: Peng
authors.affiliation: Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Cao
authors.affiliation: Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Zhao
authors.affiliation: Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Ling
authors.initials: L
authors.lastname: Cao
authors.affiliation: Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Zhao-Xia
authors.initials: ZX
authors.lastname: Zhang
authors.affiliation: Department of General Medicine, The First Affiliated Hospital, Xin Jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.affiliation: Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D019270:Fructosamine / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D019270:Fructosamine