title: Non-alcoholic fatty liver disease following liver transplantation: a clinical review.
abstract: Non-alcoholic steatohepatitis (NASH) is rapidly becoming the leading indication for liver transplantation (LT) in the United States. While post-transplantation outcomes are similar to other indications for transplant, recent evidence has suggested that reduction in risk factors for post-transplant metabolic syndrome may impose a significant survival benefit in this patient population. Cardiovascular mortality is the leading cause of death following transplantation for NASH. While pre-transplant pharmacologic and surgical approaches have been utilized to reduce cardiovascular risk factors following transplantation, the effectiveness of these treatment approaches in the post-transplant setting is poorly defined. Studies are urgently needed in the treatment of this rapidly growing population.
authors.affiliation: Section of Transplantation and Immunology, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Merola
authors.affiliation: Division of Digestive Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: AnnMarie
authors.initials: A
authors.lastname: Liapakis
authors.affiliation: Section of Transplantation and Immunology, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Mulligan
authors.affiliation: Section of Transplantation and Immunology, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Yoo
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003131:Combined Modality Therapy; D006801:Humans; D016031:Liver Transplantation; D024821:Metabolic Syndrome / Q000209:etiology / Q000517:prevention & control; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000209:etiology / Q000601:surgery* / Q000628:therapy; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D012307:Risk Factors; D016896:Treatment Outcome
keywords: fatty liver disease; non-alcoholic steatohepatitis; transplantation