title: [Determination of 14 pesticide residues in honey by ultra high performance liquid chromatography-high resolution mass spectrometry].
abstract: OBJECTIVE
  To establish a method for simultaneous determination of 14 pesticide residues in honey by ultra high performance liquid chromatography-high resolution mass spectrometry ( UPLC-HRMS).
  
  
  METHODS
  Honey samples were extracted with 1% formic acid in acetonitrile, and the extracts were cleaned up with dispersive solid phase extraction (d-SPE ) using the mixture of PSA and C18 powder as sorbents. The extract components were separated on an Accucore aQ C18 column (2.6 μm, 2.1 mm x 150 mm) by gradient elution. The qualitative and quantitative analyses were operated under Full Scan/ddms2 mode by high resolution mass spectrometry.
  
  
  RESULTS
  The response of each pesticides showed a good linearity with the correlation coefficient not less than 0.998. The limits of quantitation ( LOQs, S/N ≥ 10) for the 14 pesticides in honey were from 0.6 to 6 μg/kg. The recovery results with spike blank honey samples at the levels of LOQs, 15 and 30 μg/kg were satisfied with average recovery rates of 80.3% -112.7% and the RSDs of 0.4% -7.1%.
  
  
  CONCLUSIONS
  The proposed method was suitable for the rapid screening and quantitative analysis of pesticide residues in honey.
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002853:Chromatography, Liquid; D005506:Food Contamination / Q000032:analysis; D006722:Honey / Q000032:analysis*; D013058:Mass Spectrometry; D010573:Pesticide Residues / Q000032:analysis*; D010575:Pesticides; D052616:Solid Phase Extraction / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D010573:Pesticide Residues; D010575:Pesticides