title: Preliminary in vitro evaluation of genistein chemopreventive capacity as a result of esterification and cyclodextrin encapsulation.
abstract: The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment.
authors.affiliation: Department of Pharmacognosy, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
authors.forename: Corina
authors.initials: C
authors.lastname: Danciu
authors.affiliation: Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
authors.forename: Codruta
authors.initials: C
authors.lastname: Soica
authors.affiliation: Department of Toxicology, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Dehelean
authors.affiliation: Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eotvos utca 6, Szeged 6720, Hungary.
authors.forename: Istvan
authors.initials: I
authors.lastname: Zupko
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Dómtér 8., Szeged 6720, Hungary.
authors.forename: Erzsebet
authors.initials: E
authors.lastname: Csanyi
authors.affiliation: Department of Toxicology, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
authors.forename: Iulia
authors.initials: I
authors.lastname: Pinzaru
mesh_terms: D002152:Calorimetry, Differential Scanning; D045744:Cell Line, Tumor; D018890:Chemoprevention; D003505:Cyclodextrins / Q000737:chemistry*; D004951:Esterification; D019833:Genistein / Q000737:chemistry* / Q000627:therapeutic use*; D006801:Humans; D008855:Microscopy, Electron, Scanning
chemical_list: D003505:Cyclodextrins; D019833:Genistein