title: Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
abstract: FADS1 (fatty acid desaturase 1) plays a crucial role in fatty acid metabolism, and it was recently reported to be involved in tumorigenesis. However, the role of FADS1 expression in esophageal squamous cell carcinoma (ESCC) remains unknown. In the current study, we investigated the expression and clinical pathologic and prognostic significance of FADS1 in ESCC. Immunohistochemical analyses revealed that 58.2% (146/251) of the ESCC tissues had low levels of FADS1 expression, whereas 41.8% (105/251) exhibited high levels of FADS1 expression. In positive cases, FADS1 expression was detected in the cytoplasm of cells. Correlation analyses demonstrated that FADS1 expression was significantly correlated with tumor location (p=0.025) but not with age, gender, histological grade, tumor status, nodal status or TNM staging. Furthermore, patients with tumors expressing high levels of FADS1had a longer disease-free survival time (p<0.001) and overall survival time (p<0.001). Univariate and multivariate analyses revealed that, along with nodal status, FADS1 expression was an independent and significant predictive factor (p<0.001). In conclusion, our study suggested that FADS1 might be a valuable biomarker and potential therapeutic target for ESCC.
authors.affiliation: State Key Laboratory of Oncology in South China, Departments of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China E-mail : zengmsh@mail.sysu.edu.cn, liyong@sysucc.org.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Du
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Yan
authors.forename: Wan-Yi
authors.initials: WY
authors.lastname: Gu
authors.forename: Fan
authors.initials: F
authors.lastname: He
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Huang
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Ren-Hui
authors.initials: RH
authors.lastname: Chen
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhong
authors.forename: Man-Zhi
authors.initials: MZ
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Mu-Sheng
authors.initials: MS
authors.lastname: Zeng
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D000090943:Delta-5 Fatty Acid Desaturase; D004938:Esophageal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human