title: High maternal serum ferritin in early pregnancy and risk of spontaneous preterm birth.
abstract: Previous studies have reported inconsistent associations between maternal serum ferritin concentrations and the risk of spontaneous preterm birth (sPTB). The aim of the present study was to examine the association between Fe biomarkers, including serum ferritin concentrations, and the risk of total ( 75th percentile ( ≥ 43 μg/l) (OR 1.49, 95% CI 1.06, 2.10) and >90th percentile ( ≥ 68 μg/l) (OR 1.92, 95% CI 1.25, 2.96). Increased odds of early and moderate-to-late sPTB were associated with ferritin levels >90th percentile (OR 2.50, 95% CI 1.32, 4.73) and >75th percentile (OR 1.56, 95% CI 1.03, 2.37), respectively. No association was found between the risk of sPTB and elevated sTfR levels or Fe deficiency. In conclusion, elevated maternal serum ferritin levels in early pregnancy are associated with an increased risk of sPTB from 34 weeks of gestation. The usefulness of early pregnancy ferritin levels in identifying women at risk of sPTB warrants further investigation.
authors.affiliation: Clinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Royal North Shore Hospital,B52, St Leonards,Sydney,NSW2065,Australia.
authors.forename: Amina Z
authors.initials: AZ
authors.lastname: Khambalia
authors.affiliation: Priority Research Centre for Physical Activity and Nutrition, Faculty of Health and Medicine, School of Health Sciences, University of Newcastle,Callaghan,NSW2308,Australia.
authors.forename: Clare E
authors.initials: CE
authors.lastname: Collins
authors.affiliation: Clinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Royal North Shore Hospital,B52, St Leonards,Sydney,NSW2065,Australia.
authors.forename: Christine L
authors.initials: CL
authors.lastname: Roberts
authors.affiliation: Clinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Royal North Shore Hospital,B52, St Leonards,Sydney,NSW2065,Australia.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Morris
authors.affiliation: Pathology North, NSW Health Pathology, Royal North Shore Hospital,St Leonards,NSW,Australia.
authors.forename: Katie L
authors.initials: KL
authors.lastname: Powell
authors.affiliation: Pathology North, NSW Health Pathology, Royal North Shore Hospital,St Leonards,NSW,Australia.
authors.forename: Vitomir
authors.initials: V
authors.lastname: Tasevski
authors.affiliation: Clinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Royal North Shore Hospital,B52, St Leonards,Sydney,NSW2065,Australia.
authors.forename: Natasha
authors.initials: N
authors.lastname: Nassar
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood*; D005322:Premature Rupture of Fetal Membranes / Q000097:blood; D005865:Gestational Age; D006801:Humans; D007501:Iron / Q000097:blood; D009517:New South Wales; D007752:Obstetric Labor, Premature / Q000097:blood; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood*; D011990:Receptors, Transferrin / Q000097:blood; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D011990:Receptors, Transferrin; D005293:Ferritins; D007501:Iron
keywords: Ferritin; Iron; Pregnancy; Preterm; Risk factors