title: Chronic Pancreatitis with Acinar-Ductal Metaplasia and Ductal Dysplasia in a Horse.
abstract: A 16-year-old Friesian gelding with relapsing colic was humanely destroyed during diagnostic laparotomy due to suspected abdominal neoplasia. On post-mortem examination, the pancreas appeared as a firm mass (20 × 8 × 8 cm). The cut surface had a lobular structure with multiple cavities. Histological examination revealed severe chronic fibrosing pancreatitis with acinar-ductal metaplasia and duct dysplasia, which was considered to be the cause of the recurrent colic. Formation of tubular complexes within a background of acinar-ductal metaplasia is similar to the regressive lesions detected in the human pancreas in the context of inflammation, duct obstruction, cystic fibrosis and neoplasia. Pancreatic acinar-ductal metaplasia and ductal dysplasia are considered to be preneoplastic conditions in man and in the mouse.
authors.affiliation: Institute of Veterinary Pathology, Ludwig Maximilians University, Munich, Germany. Electronic address: leipig@patho.vetmed.uni-muenchen.de.
authors.forename: M
authors.initials: M
authors.lastname: Leipig
authors.affiliation: Institute of Veterinary Pathology, Ludwig Maximilians University, Munich, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Abenthum
authors.affiliation: Clinic for Horses at the Centre for Clinical Veterinary Medicine, Ludwig Maximilians University, Munich, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Wollanke
authors.affiliation: Clinic for Horses at the Centre for Clinical Veterinary Medicine, Ludwig Maximilians University, Munich, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Czupalla
authors.affiliation: Department of Pathology, Technische Universität, Munich, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Esposito
authors.affiliation: Department of Pathology, Technische Universität, Munich, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Steiger
authors.affiliation: Institute of Veterinary Pathology, Ludwig Maximilians University, Munich, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hermanns
authors.affiliation: Institute of Veterinary Pathology, Ludwig Maximilians University, Munich, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Herbach
mesh_terms: D000818:Animals; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D008297:Male; D008679:Metaplasia; D010183:Pancreatic Ducts / Q000473:pathology*; D050500:Pancreatitis, Chronic / Q000473:pathology / Q000662:veterinary*
keywords: chronic pancreatitis; dysplasia; horse; metaplasia