title: Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin.
abstract: Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by increasing the protein level of Sirtuins, which prevented metabolic disorders to mimic the effect of calorie restriction. Experiments in vitro showed that cAMP directly bound to SIRT1 and SIRT3 and consequently increased their activity. These findings suggest that cAMP slows the ageing process and is a good candidate to mimic calorie restriction. Our research provides a promising therapeutic strategy to target metabolic disorder-induced ageing-related diseases.
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Zhuoran
authors.initials: Z
authors.lastname: Wang
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Yaru
authors.initials: Y
authors.lastname: Liang
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Xu
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Lang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: 1] MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China [2] Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo 226-8051, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Fuji
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Mu
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Li
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Junjun
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of chemistry, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ju
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D031204:Caloric Restriction; D016922:Cellular Senescence; D000242:Cyclic AMP / Q000378:metabolism* / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D018384:Oxidative Stress / Q000187:drug effects; D010641:Phenotype; D056564:Sirtuin 1 / Q000378:metabolism; D056566:Sirtuin 3 / Q000378:metabolism; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D000242:Cyclic AMP; D056564:Sirtuin 1; D056566:Sirtuin 3; D037761:Sirtuins