title: Comparative Efficacy of an Imidacloprid/Flumethrin Collar (Seresto®) and an Oral Fluralaner Chewable Tablet (Bravecto®) against Tick (Dermacentor variabilis and Amblyomma americanum) Infestations on Dogs: a Randomised Controlled Trial.
abstract: This controlled laboratory study demonstrated the residual speed of efficacy of an imidacloprid/flumethrin collar (Seresto(®), Bayer) for the control of ticks (Dermacentor variabilis, Amblyomma americanum) at 6 and 12 hours post-infestation on dogs when compared to oral fluralaner (Bravecto(®), Merck). Dogs were randomised by pre-treatment tick counts: Group 1) imidacloprid 10 % (w/w)/flumethrin 4.5 % (w/w) collar, 2) fluralaner (dosage 25.1 - 49.4 mg/kg), and 3) non-treated controls. Ticks (50/species/dog) were infested on days 3, 14, 21, 28, 42, and 56 followed by 50 D. variabilis on days 70 and 84. Live and dead attached ticks were counted 6 and 12 hours later. Efficacy against both species at 6 and 12 hours for Group 1 was 94 - 100 %. Efficacy for Group 2 against both species at 6 hours was 4 - 69 %; efficacy at 12 hours was 8 - 100 %. Live (attached and non-attached) tick counts at 6 hours in Group 1 were significantly lower (p ≤ 0.05) than counts in Group 2 and 3 on all days. At 12 hours, live counts were significantly lower (p ≤ 0.05) in Group 1 than Group 2 for D. variabilis from days 56 - 84 and for A. americanum from days 28 - 56. There were significantly fewer (p ≤ 0.05) total ticks (total live and dead attached) on dogs in Group 1 compared to Group 2 and 3 at all time points. This study demonstrated that an imidacloprid/flumethrin collar was highly efficacious (94 - 100 %) at repelling and killing ticks on dogs at 6 and 12 hours post-infestation and was more efficacious than fluralaner as early as 6 hours post-infestation on all challenge days.
authors.affiliation: Bayer HealthCare, LLC, Animal Health, Shawnee, KS, 66201, USA, Cameon.Ohmes@bayer.com.
authors.forename: Cameon M
authors.initials: CM
authors.lastname: Ohmes
authors.forename: Joe
authors.initials: J
authors.lastname: Hostetler
authors.forename: Wendell L
authors.initials: WL
authors.lastname: Davis
authors.forename: Terry
authors.initials: T
authors.lastname: Settje
authors.forename: Amy
authors.initials: A
authors.lastname: McMinn
authors.forename: William R
authors.initials: WR
authors.lastname: Everett
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology*; D004285:Dogs; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D026863:Ixodidae / Q000187:drug effects*; D008297:Male; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D011722:Pyrethrins / Q000008:administration & dosage / Q000627:therapeutic use*; D013984:Tick Infestations / Q000188:drug therapy / Q000662:veterinary*
chemical_list: C000591860:A1443 compound; D007093:Imidazoles; D007555:Isoxazoles; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011722:Pyrethrins; C041392:flumethrin; C082359:imidacloprid