title: Disruption of White Matter Integrity in Adult Survivors of Childhood Brain Tumors: Correlates with Long-Term Intellectual Outcomes.
abstract: BACKGROUND
  Although chemotherapy and radiation treatment have contributed to increased survivorship, treatment-induced brain injury has been a concern when examining long-term intellectual outcomes of survivors. Specifically, disruption of brain white matter integrity and its relationship to intellectual outcomes in adult survivors of childhood brain tumors needs to be better understood.
  
  
  METHODS
  Fifty-four participants underwent diffusion tensor imaging in addition to structural MRI and an intelligence test (IQ). Voxel-wise group comparisons of fractional anisotropy calculated from DTI data were performed using Tract Based Spatial Statistics (TBSS) on 27 survivors (14 treated with radiation with and without chemotherapy and 13 treated without radiation treatment on average over 13 years since diagnosis) and 27 healthy comparison participants. Whole brain white matter fractional anisotropy (FA) differences were explored between each group. The relationships between IQ and FA in the regions where statistically lower FA values were found in survivors were examined, as well as the role of cumulative neurological factors.
  
  
  RESULTS
  The group of survivors treated with radiation with and without chemotherapy had lower IQ relative to the group of survivors without radiation treatment and the healthy comparison group. TBSS identified white matter regions with significantly different mean fractional anisotropy between the three different groups. A lower level of white matter integrity was found in the radiation with or without chemotherapy treated group compared to the group without radiation treatment and also the healthy control group. The group without radiation treatment had a lower mean FA relative to healthy controls. The white matter disruption of the radiation with or without chemotherapy treated survivors was positively correlated with IQ and cumulative neurological factors.
  
  
  CONCLUSIONS
  Lower long-term intellectual outcomes of childhood brain tumor survivors are associated with lower white matter integrity. Radiation and adjunct chemotherapy treatment may play a role in greater white matter disruption. The relationships between white matter integrity and IQ, as well as cumulative neurological risk factors exist in young adult survivors of childhood brain tumors.
authors.affiliation: Department of Psychology & Neuroscience Institute, Georgia State University, Atlanta, Georgia, United States of America.
authors.forename: Tricia Z
authors.initials: TZ
authors.lastname: King
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America.
authors.forename: Liya
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America.
authors.forename: Hui
authors.initials: H
authors.lastname: Mao
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology / Q000532:radiotherapy; D002648:Child; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D011879:Radiotherapy Dosage; D017741:Survivors; D066127:White Matter / Q000473:pathology*; D055815:Young Adult