title: GEP-NETs UPDATE: Secreting gastro-enteropancreatic neuroendocrine tumours and biomarkers.
abstract: Neuroendocrine tumours (NETs) are rare tumours with an annual incidence in the population in a range of 2-5 new cases per 100,000 inhabitants. NETs are widely variable in terms of anatomical location, hormone production, clinical behaviour and syndromes they can cause. This article reviews the many localizations and clinical presentations of NETs with a main focus on clinical biomarkers and their use in medical practice.
authors.affiliation: Departments of GastroenterologyClinical ChemistryMedical OncologyThe Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: Wieke H M
authors.initials: WH
authors.lastname: Verbeek
authors.affiliation: Departments of GastroenterologyClinical ChemistryMedical OncologyThe Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: Catharina M
authors.initials: CM
authors.lastname: Korse
authors.affiliation: Departments of GastroenterologyClinical ChemistryMedical OncologyThe Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands m.tesselaar@nki.nl.
authors.forename: Margot E T
authors.initials: ME
authors.lastname: Tesselaar
mesh_terms: D015415:Biomarkers / Q000097:blood*; D053379:Chromogranin A / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D020097:Natriuretic Peptide, Brain / Q000097:blood; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D009928:Organ Specificity; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D010191:Pancreatic Polypeptide / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D011994:Recombinant Proteins / Q000097:blood; D012701:Serotonin / Q000097:blood; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy
chemical_list: D015415:Biomarkers; D053379:Chromogranin A; D010446:Peptide Fragments; D011994:Recombinant Proteins; C109794:pro-brain natriuretic peptide (1-76); C087079:pro-gastrin-releasing peptide (31-98); D020097:Natriuretic Peptide, Brain; D012701:Serotonin; D010191:Pancreatic Polypeptide