title: In vitro and in silico toxicity evaluation of bioactive 4'-aminochalcone derivatives.
abstract: The 4'-aminochalcones compounds are open-chain flavonoids structures which have shown a known array of pharmacological activities, such as antibacterial, antifungal, anti-inflammatory and antitumor effects. There is little toxicological information available about these compounds in the literature. Therefore, the investigation of toxic effects of three 4'-aminochalcone derivatives was performed using in silico and in vitro assays. In silico provided results that indicated the occurrence of mutagenic and genotoxic effects. In vitro tests, using Cellular Proliferation and Viability, Micronucleus, and DNA damage by Comet assay, showed that the compounds studied also present mutagenic and genotoxic effects, which confirm the result determined by the in silico analysis. The use of experimental and computational models is complementary to each other and the results determined for 4'-aminochalones suggest that the chalcones should also be carefully considered since they show some risks to cause toxic effects to human cells.
authors.affiliation: a Programa de Pós-Graduação em Ciências Farmacêuticas and.
authors.forename: Patrícia Albano
authors.initials: PA
authors.lastname: Mariño
authors.affiliation: b Curso de Farmácia, Universidade Federal do Pampa , Uruguaiana , RS , Brazil.
authors.forename: Danillo Baptista
authors.initials: DB
authors.lastname: Pereira
authors.affiliation: b Curso de Farmácia, Universidade Federal do Pampa , Uruguaiana , RS , Brazil.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Santi
authors.affiliation: b Curso de Farmácia, Universidade Federal do Pampa , Uruguaiana , RS , Brazil.
authors.forename: Raul Oliveira
authors.initials: RO
authors.lastname: de Souza
authors.affiliation: a Programa de Pós-Graduação em Ciências Farmacêuticas and.|b Curso de Farmácia, Universidade Federal do Pampa , Uruguaiana , RS , Brazil.
authors.forename: Débora
authors.initials: D
authors.lastname: Faoro
authors.affiliation: a Programa de Pós-Graduação em Ciências Farmacêuticas and.|b Curso de Farmácia, Universidade Federal do Pampa , Uruguaiana , RS , Brazil.
authors.forename: Luís Flávio Souza
authors.initials: LF
authors.lastname: de Oliveira
authors.affiliation: a Programa de Pós-Graduação em Ciências Farmacêuticas and.|b Curso de Farmácia, Universidade Federal do Pampa , Uruguaiana , RS , Brazil.
authors.forename: Michel Mansur
authors.initials: MM
authors.lastname: Machado
authors.affiliation: a Programa de Pós-Graduação em Ciências Farmacêuticas and.|b Curso de Farmácia, Universidade Federal do Pampa , Uruguaiana , RS , Brazil.
authors.forename: Fávero Reisdorfer
authors.initials: FR
authors.lastname: Paula
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000473:pathology; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D008954:Models, Biological; D018675:Toxicity Tests
chemical_list: D047188:Chalcones
keywords: Chalcones; computational toxicity evaluation; genotoxicity; mutagenicity