title: Effects of a weight loss program on body composition and the metabolic profile in obese postmenopausal women displaying various obesity phenotypes: a MONET group study.
abstract: Obesity is a heterogeneous condition, since the metabolic profile may differ greatly from one individual to another. The objective of this study was to compare the effect of a 6-month diet-induced weight loss program on body composition and the metabolic profile in obese individuals displaying different obesity phenotypes. Secondary analyses were done on 129 obese (% body fat: 46% ± 4%) postmenopausal women (age: 57 ± 4 years). Outcome measures included body composition, body fat distribution, glucose homeostasis, fasting lipids, and blood pressure. Obesity phenotypes were determined based on lean body mass (LBM) index (LBMI = LBM/height(2)) and visceral fat (VF) accumulation, as follows: 1, lower VF and lower LBMI (n = 35); 2, lower VF and higher LBMI (n = 19); 3, higher VF and lower LBMI (n = 14); and 4, higher VF and higher LBMI (n = 61). All groups had significantly improved measures of body composition after the intervention (P < 0.0001). Greater decreases in LBM and LBMI were observed in the higher LBMI groups than in the lower LBMI groups (P < 0.0001). Similarly, decreases in VF were greater in the higher VF groups than in the lower VF groups (P < 0.05). Overall, fasting insulin levels and glucose disposal improved following the intervention, with higher LBMI groups showing a trend for greater improvements (P = 0.06 and 0.07, respectively). Overall, no difference was observed among the different obesity phenotypes regarding improvements in the metabolic profile in response to weight loss. Individuals displaying higher VF or higher LBMI at baseline experienced significantly greater decreases for these variables after the intervention.
authors.affiliation: a Faculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.|b Research Centre on Aging, Institute of Geriatrics of Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Eve
authors.initials: E
authors.lastname: Normandin
authors.affiliation: c Faculty of Health Sciences, School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Doucet
authors.affiliation: d Department of Nutrition, Université de Montréal, Montreal, QC, Canada.|e Montreal Diabetes Research Centre, Montreal, QC, Canada.|f Institut de recherches cliniques de Montréal, Montreal, QC, Canada.
authors.forename: Rémi
authors.initials: R
authors.lastname: Rabasa-Lhoret
authors.affiliation: a Faculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.|b Research Centre on Aging, Institute of Geriatrics of Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Brochu
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition / Q000502:physiology*; D050218:Body Fat Distribution / Q000706:statistics & numerical data; D005215:Fasting; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000628:therapy*; D010641:Phenotype; D017698:Postmenopause / Q000502:physiology*; D061217:Weight Reduction Programs
chemical_list: D001786:Blood Glucose
keywords: graisse viscérale; lean body mass; masse maigre; metabolic profile; profil métabolique; visceral fat