title: Dioxin-like biological activity of organic extracts from sediments and fish livers sampled along the Israeli Mediterranean and Red Sea coasts.
abstract: This study provides, for the first time, a baseline evaluation of dioxin-like biological activity in sediments and fish sampled in- and adjacent to anchorages along the Mediterranean and Red Sea coasts of Israel. It indicates the effect of past pollution, still present in the sediments of older Israeli harbors, with putative contribution of still existing sources of pollution. A commercial reporter gene bioassay was used to evaluate the biological activity of dioxin-like compounds extracted from the samples. HRGC/HRMS analysis of several samples contributed a profile of dioxin-like compounds in sediments and fish. The results point out 1,2,3,4,6,7,8-HeptaCDD, 2,3,4,6,7,8-HexaCDF, 1,2,3,4,6,7,8-HeptaCDF, РСВ-126 and РСВ-118 as major contributors to the dioxin-like activity in sediments. It indicates polychlorinated biphenyls non-selective absorption in fish livers, in contrary to a biased accumulation of poorly chlorinated and more potent dibenzodioxins and dibenzofurans.
authors.affiliation: Israel Oceanographic and Limnological Research, P.O.B. 8030, Haifa 31080, Israel.
authors.forename: Yana
authors.initials: Y
authors.lastname: Yudkovski
authors.affiliation: Israel Oceanographic and Limnological Research, P.O.B. 8030, Haifa 31080, Israel.
authors.forename: Barak
authors.initials: B
authors.lastname: Herut
authors.affiliation: Israel Oceanographic and Limnological Research, P.O.B. 8030, Haifa 31080, Israel.
authors.forename: Edna
authors.initials: E
authors.lastname: Shefer
authors.affiliation: Israel Oceanographic and Limnological Research, P.O.B. 8030, Haifa 31080, Israel. Electronic address: tom@ocean.org.il.
authors.forename: Moshe
authors.initials: M
authors.lastname: Tom
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000493:pharmacokinetics / Q000633:toxicity; D001681:Biological Assay / Q000379:methods*; D004147:Dioxins / Q000493:pharmacokinetics / Q000633:toxicity*; D004784:Environmental Monitoring; D005399:Fishes; D017930:Genes, Reporter; D019015:Geologic Sediments / Q000032:analysis* / Q000737:chemistry; D019156:Indian Ocean; D007557:Israel; D008099:Liver / Q000737:chemistry*; D008522:Mediterranean Sea; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity; D014020:Tissue Extracts / Q000032:analysis / Q000737:chemistry / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D001572:Benzofurans; D004147:Dioxins; D014020:Tissue Extracts; D014874:Water Pollutants, Chemical; C512003:dibenzodioxin; C023614:dibenzofuran; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl
keywords: DR-CALUX reporter gene assay; Dioxin-like activity; Israel coastal environment; Polychlorinated biphenyls; Polychlorinated dibenzodioxins/dibenzofurans