title: [Effect of H2-receptor antagonist and proton pomp inhibitor on the treatment of acid-related disease].
abstract: We summarized proton pump inhibitors(PPI) and histamine H2-receptor antagonist (H2B) with reference to acid-related disease. The both drugs act process of gastric acid secretion in parietal cell of stomach. Inhibition of H2B is reversible, but that of PPI is irreversible, so period of acting in PPI is longer than that in H2B. PPI is more effective than H2B in treatment of acid-related disease. Especially PPI is recommended the first choice in GERD and NSAID ulcer.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawai
authors.forename: Kenji
authors.initials: K
authors.lastname: Yagi
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
mesh_terms: D004381:Duodenal Ulcer / Q000188:drug therapy; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors