title: Bevacizumab alleviates radiation-induced brain necrosis: A report of four cases.
abstract: To analyze the therapeutic effect of bevacizumab on radiation-induced brain necrosis. Four radiation-induced brain necrosis patients, administered with bevacizumab at a dose of 7.5 mg/kg every 3 weeks, 2 times. One case of brain metastasis of lung cancer and one case of nasopharyngeal carcinoma with brain necrosis after radiotherapy. However, their physical signs disappeared after the treatment with bevacizumab. One case of brainstem lesion and one case of brain glioma patient showed a transient improvement in signs and symptoms after treatment with bevacizumab. Bevacizumab can significantly alleviate the radiation-induced brain edema, and can improve the symptoms successively.
authors.forename: Li
authors.initials: L
authors.lastname: Xiang-Pan
authors.forename: Chu
authors.initials: C
authors.lastname: Yuxin
authors.forename: Wu
authors.initials: W
authors.lastname: Xiao-Fei
authors.forename: Li
authors.initials: L
authors.lastname: Na
authors.forename: Xu
authors.initials: X
authors.lastname: Tang-Peng
authors.forename: Xu
authors.initials: X
authors.lastname: Xiao-Tao
authors.forename: Ruan
authors.initials: R
authors.lastname: Chang-Li
authors.affiliation: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Wei-Guo
authors.affiliation: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.
authors.forename: Song
authors.initials: S
authors.lastname: Qi-Bin
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002277:Carcinoma; D002648:Child; D005260:Female; D005910:Glioma / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000473:pathology; D009336:Necrosis / Q000188:drug therapy* / Q000473:pathology; D011832:Radiation Injuries / Q000188:drug therapy* / Q000473:pathology
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab