title: Computerized Analysis of Vocal Folds Vibration From Laryngeal Videostroboscopy.
abstract: OBJECTIVE
  To develop an objective analysis of laryngeal videostroboscopy (VSS) movies in the space-time domain for quantitative determination of the true vocal folds (TVFs) vibratory pattern to allow for detection of local pathologies at early stages of development.
  
  
  METHODS
  Contours of the TVF and false vocal folds (FVFs) were tracked on each frame of a VSS movie. A registration algorithm was used with respect to the centerline of the FVF to eliminate movements not related to TVF vibration. The registered contours of the TVF were analyzed in time and frequency domains.
  
  
  RESULTS
  The TVF vibration demonstrated a sinusoidal pattern with the same fundamental frequency at every section along the folds of healthy subjects, as well as detection of an abnormal area with a different fundamental frequency in TVF with local pathologies. Analysis of the TVF vibration time delay of healthy subject revealed a posterior-to-anterior longitudinal wave that was not detected by visual observation.
  
  
  CONCLUSIONS
  An objective analysis of laryngeal VSS movies was developed for quantitative determination of the TVF vibration. This analysis was able to detect and quantify TVF characteristics in normal subjects as well as in patients with pathologies beyond the ability of examinee's naked eyes.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Silvia
authors.initials: S
authors.lastname: Gora
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Noy
authors.initials: N
authors.lastname: Yavin
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel. Electronic address: elad@post.tau.ac.il.
authors.forename: David
authors.initials: D
authors.lastname: Elad
authors.affiliation: Department of Otorhinolaryngology, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Wolf
authors.affiliation: Department of Otorhinolaryngology, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Primov-Fever
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D016022:Case-Control Studies; D003560:Cysts / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D007828:Laryngoscopy; D008297:Male; D010363:Pattern Recognition, Automated; D010699:Phonation; D011237:Predictive Value of Tests; D049489:Stroboscopy; D013997:Time Factors; D014732:Vibration; D014741:Video Recording; D014827:Vocal Cords / Q000473:pathology / Q000503:physiopathology*
keywords: Active contours; Videostroboscopy; Vocal folds vibration