title: Biodegradable fibre scaffolds incorporating water-soluble drugs and proteins.
abstract: A new type of biodegradable drug-loaded fibre scaffold has been successfully produced for the benefit of water-soluble drugs and proteins. Model drug loaded calcium carbonate (CaCO3) microparticles incorporated into poly(lactic acid-co-glycolic acid) (PLGA) fibres were manufactured by co-precipitation of CaCO3 and the drug molecules, followed by electrospinning of a suspension of such drug-loaded microparticles in a PLGA solution. Rhodamine 6G and bovine serum albumin were used as model drugs for our release study, representing small bioactive molecules and protein, respectively. A bead and string structure of fibres was achieved. The drug release was investigated with different drug loadings and in different pH release mediums. Results showed that a slow and sustained drug release was achieved in 40 days and the CaCO3 microparticles used as the second barrier restrained the initial burst release.
authors.affiliation: School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
authors.forename: J
authors.initials: J
authors.lastname: Ma
authors.forename: J
authors.initials: J
authors.lastname: Meng
authors.forename: M
authors.initials: M
authors.lastname: Simonet
authors.forename: N
authors.initials: N
authors.lastname: Stingelin
authors.forename: T
authors.initials: T
authors.lastname: Peijs
authors.forename: G B
authors.initials: GB
authors.lastname: Sukhorukov
mesh_terms: D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011506:Proteins / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004364:Pharmaceutical Preparations; D011506:Proteins; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid