title: [Molecular Mechanism of Action of hnRNP K and RTN3 in the Replication of Enterovirus 71].
abstract: Enterovirus 71 (EV71) is a neurotropic pathogen that can induce hand, foot and mouth disease in children. There is an appreciable mortality rate after EV71 infections. The mechanism of action of EV71 replication is not known. Recent work has identified some of cell factors of the host that participate in the synthesis of the RNA and proteins of EV71 (e.g., hnRNP K, reticulon 3 (RTN 3)). In that work, researchers used a competitive assay to show that hnRNP K can interact with EV71 5' UTR, which is required for efficient synthesis of viral RNA. Using a yeast two-hybrid system, other researchers demonstrated that RTN 3 interacts with the N-terminal domain of EV71 2C, which is crucial for replication of viral RNA. Here, we discuss recent work focusing on the molecular mechanisms of hnRNP K and RTN 3 in the synthesis of the RNA and proteins of EV71.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhong
authors.forename: Mao
authors.initials: M
authors.lastname: Fan
authors.forename: Liyue
authors.initials: L
authors.lastname: Kui
authors.forename: Huiying
authors.initials: H
authors.lastname: Li
authors.forename: Jianying
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D029821:Enterovirus A, Human / Q000235:genetics / Q000502:physiology*; D004769:Enterovirus Infections / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D054884:Host-Pathogen Interactions; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000235:genetics / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication
chemical_list: D002352:Carrier Proteins; D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C476198:RTN3 protein, human; D012261:Ribonucleoproteins; D014764:Viral Proteins; C072074:HNRNPK protein, human