title: New tumour antigen PLAC1/CP1, a potentially useful prognostic marker and immunotherapy target for gastric adenocarcinoma.
abstract: OBJECTIVE
  To evaluate protein expression and clinical significance of PLAC1/CP1 antigen in primary gastric adenocarcinoma.
  
  
  METHODS
  Protein expression of PLAC1/CP1 was analysed by tissue chip and immunohistochemistry in surgical specimens obtained from 119 patients with gastric cancer. The data were analysed using SPSS V.16.0 software applying the χ(2) test and Kaplan-Meier method.
  
  
  RESULTS
  The positive expression frequency of PLAC1/CP1 protein was 61.3% (73/119 patients). The overall survival of patients with PLAC1/CP1 protein-positive expression was significantly lower than that of patients with PLAC1/CP1 protein-negative expression (p<0.05). There was no significant relationship between PLAC1/CP1 expression and patient gender, age, tumour position, tumour size, differentiation, gross type, lymph node or TNM stage.
  
  
  CONCLUSIONS
  PLAC1/CP1 protein is expressed in over half of cases of primary gastric cancer, and PLAC1/CP1 protein expression is inversely correlated with patient survival. The data indicate that PLAC1/CP1 provides a marker for identifying gastric cancers with poor prognosis, and suggest that PLAC1/CP1 may provide a useful target for immunotherapy.
authors.affiliation: Department of Pathology, Peking University People's Hospital, Beijing, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Pathology, Peking University People's Hospital, Beijing, China.
authors.forename: Danhua
authors.initials: D
authors.lastname: Shen
authors.affiliation: Department of Statistics Office, Peking University Health Science Center, Beijing, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Kang
authors.affiliation: Department of Clinical Epidemiology, Peking University People's Hospital, Beijing, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Peking University People's Hospital, Beijing, China.
authors.forename: Qiujing
authors.initials: Q
authors.lastname: Song
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007167:Immunotherapy / Q000379:methods; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011257:Pregnancy Proteins / Q000032:analysis / Q000096:biosynthesis*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D046888:Tissue Array Analysis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C415583:PLAC1 protein, human; D011257:Pregnancy Proteins
keywords: GASTRIC CANCER; IMMUNOHISTOCHEMISTRY; PROTEINS; TUMOUR IMMUNITY; TUMOUR MARKERS