title: Semipermeable Hollow Fiber Phantoms for Development and Validation of Perfusion-Sensitive MR Methods and Signal Models.
abstract: Two semipermeable, hollow fiber phantoms for the validation of perfusion-sensitive magnetic resonance methods and signal models are described. Semipermeable hollow fibers harvested from a standard commercial hemodialysis cartridge serve to mimic tissue capillary function. Flow of aqueous media through the fiber lumen is achieved with a laboratory-grade peristaltic pump. Diffusion of water and solute species (e.g., Gd-based contrast agent) occurs across the fiber wall, allowing exchange between the lumen and the extralumenal space. Phantom design attributes include: i) small physical size, ii) easy and low-cost construction, iii) definable compartment volumes, and iv) experimental control over media content and flow rate.
authors.affiliation: Department of Chemistry, Washington University, 1 Brookings Drive, St. Louis, MO 63130.
authors.forename: J R
authors.initials: JR
authors.lastname: Anderson
authors.affiliation: Department of Chemistry, Washington University, 1 Brookings Drive, St. Louis, MO 63130 ; Department of Radiology, Washington University, 1 Brookings Drive, St. Louis, MO 63130 ; Department of Internal Medicine, Washington University, 1 Brookings Drive, St. Louis, MO 63130.
authors.forename: J J H
authors.initials: JJ
authors.lastname: Ackerman
authors.affiliation: Department of Radiology, Washington University, 1 Brookings Drive, St. Louis, MO 63130.
authors.forename: J R
authors.initials: JR
authors.lastname: Garbow
keywords: MR phantom design; dialyzer; hollow fiber bioreactor; perfusion; semipermeable hollow fiber