title: Accuracy of Endorectal Endoscopic Ultrasound (EUS) for Locally Advanced Rectal Cancer (LARC) Restaging After Neoadjuvant Chemoradiotherapy (NAT): A Meta-Analysis.
abstract: OBJECTIVE
  Endorectal endoscopic ultrasound (EUS) can provide accurate and reliable information for initial staging of locally advanced rectal cancer (LARC) in both the depth of rectal cancer penetration (T-stage) and regional lymph node involvement (N-stage). However, there is still no consensus about its accuracy in retagging LARC after neoadjuvant chemoradiotherapy (NAT).
  
  
  METHODS
  In this study, we retrieved previous studies and performed a meta-analysis for assessing the accuracy of EUS for retagging of LARC after NAT.
  
  
  RESULTS
  It was found the accuracy of EUS for T restaging of LARC was relatively low and over-staging was common, although the accuracy for assessing T3/4 was significantly higher than T0-T2 stage. The specificity of EUS for assessing N stage was relatively high, but the sensitivity was relatively low.
  
  
  CONCLUSIONS
  Data obtained in this study confirmed the overall accuracy of EUS is not sufficient to serve as a basis for decisions on restaging Exploring the possible application of new techniques is necessary for better restaging.
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Zhao
authors.forename: Dan-Ming
authors.initials: DM
authors.lastname: Cao
authors.forename: Qi-Chang
authors.initials: QC
authors.lastname: Zhou
authors.forename: Nuan
authors.initials: N
authors.lastname: Yang
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Yao
mesh_terms: D059186:Chemoradiotherapy, Adjuvant; D016009:Chi-Square Distribution; D019160:Endosonography; D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging / Q000379:methods*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D015203:Reproducibility of Results; D016896:Treatment Outcome