title: Innate immune interactions within the central nervous system modulate pathogenesis of viral infections.
abstract: The innate immune system mediates protection against neurotropic viruses that replicate in the central nervous system (CNS). Virus infection within specific cells of the CNS triggers activation of several families of pattern recognition receptors including Toll-like receptors, retinoic acid-inducible gene I like receptors, nucleotide-binding oligomerization domain-like receptors, and cytosolic DNA sensors. In this review, we highlight recent advances in our understanding of how cell-intrinsic host defenses within the CNS modulate infection of different DNA and RNA viruses.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Nair
authors.affiliation: Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: diamond@borcim.wustl.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Diamond
mesh_terms: D000818:Animals; D020805:Central Nervous System Viral Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D035683:MicroRNAs / Q000235:genetics; D011971:Receptors, Immunologic / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000821:virology*
chemical_list: D035683:MicroRNAs; D011971:Receptors, Immunologic; D014157:Transcription Factors