title: Validation of renal artery dimensions measured by magnetic resonance angiography in patients referred for renal sympathetic denervation.
abstract: OBJECTIVE
  Magnetic resonance angiography (MRA) is a well-established modality for the assessment of renal artery stenosis. Using dedicated quantitative analyses, MRA can become a useful tool for assessing renal artery dimensions in patients referred for renal sympathetic denervation (RDN) and for providing accurate measurements of vascular response after RDN. The purpose of this study was to test the reproducibility of a novel MRA quantitative imaging tool and to validate these measurements against intravascular ultrasound (IVUS).
  
  
  METHODS
  In nine patients referred for renal denervation, renal artery dimensions were measured. Bland-Altman analysis was used to assess the intraobserver and interobserver reproducibility.
  
  
  RESULTS
  Mean lumen diameter was 5.8 ± 0.7 mm, with a very good intraobserver and interobserver variability of 0.7% (reproducibility: bias, 0 mm; standard deviation [SD], 0.1 mm) and 1.2% (bias, 0 mm; SD, 0.1 mm), respectively. Mean total lumen volume was 1035.3 ± 403.6 mm(3) with good intraobserver and interobserver variability of 2.9% (bias, -9.7 mm(3); SD, 34.0 mm(3)) and 2.8% (bias, -11.4 mm(3); SD, 42.4 mm(3)). The correlation (Pearson R) between mean lumen diameter measured with MRA and IVUS was 0.750 (P = .002).
  
  
  CONCLUSIONS
  Using a novel MRA quantitative imaging tool, renal artery dimensions can be measured with good reproducibility and accuracy. MRA-derived diameters and volumes correlated well with IVUS measurements.
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands; Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Matthijs
authors.initials: M
authors.lastname: van Kranenburg
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands.
authors.forename: Antonis
authors.initials: A
authors.lastname: Karanasos
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands; Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Raluca Gabriela
authors.initials: RG
authors.lastname: Chelu
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands.
authors.forename: Elco
authors.initials: E
authors.lastname: van der Heide
authors.affiliation: Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ouhlous
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands; Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Koen
authors.initials: K
authors.lastname: Nieman
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands.
authors.forename: Nicolas
authors.initials: N
authors.lastname: van Mieghem
authors.affiliation: Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Krestin
authors.affiliation: Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Wiro
authors.initials: W
authors.lastname: Niessen
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands.
authors.forename: Felix
authors.initials: F
authors.lastname: Zijlstra
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands; Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Robert-Jan
authors.initials: RJ
authors.lastname: van Geuns
authors.affiliation: Department of Cardiology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands. Electronic address: j.daemen@erasmusmc.nl.
authors.forename: Joost
authors.initials: J
authors.lastname: Daemen
mesh_terms: D059925:Anatomic Landmarks / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000008:administration & dosage; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data; D007275:Injections, Intravenous; D007668:Kidney / Q000294:innervation*; D018810:Magnetic Resonance Angiography / Q000706:statistics & numerical data*; D015588:Observer Variation; D009942:Organometallic Compounds / Q000008:administration & dosage; D012077:Renal Artery / Q000000981:diagnostic imaging*; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging; D015203:Reproducibility of Results; D013562:Sympathectomy / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000706:statistics & numerical data
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol
keywords: Renal artery; intravascular ultrasound; magnetic resonance angiography; percutaneous renal sympathetic denervation