title: Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer.
abstract: Thyroid extracts were first used to treat patients with metastatic breast cancer over a century ago. Since then, a number of studies have investigated the association between thyroid disorders and breast cancer. The presence of antibodies to thyroid peroxidase (TPOab) was recently reported to be associated with improved outcome in these patients. The aim of the present study was to evaluate the association between TPOab positivity and clinicopathological characteristics in breast cancer patients. The study included 318 newly diagnosed cases of breast cancer treated at Ondokuz Mayis University Hospital, Samsun, Turkey, between 2008 and 2012. Serum thyroid-stimulating hormone, free triiodothyronine and free thyroxine levels were measured at the time of diagnosis. Of the 318 patients, 253 were considered to be TPOab-negative (TPOab ≤34 IU/ml) and 65 TPOab-positive (TPOab >34 IU/ml). No cases with distant metastases were found in the TPOab-positive group. However, 20 (7.9%) of the 253 patients displayed distant metastases in the TPOab-negative group (P=0.01). Therefore, TPOab positivity was found to be associated with a lower incidence of metastasis in breast cancer patients.
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Kemal
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
authors.forename: Guzin
authors.initials: G
authors.lastname: Demirag
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
authors.forename: Kubilay
authors.initials: K
authors.lastname: Ekiz
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
authors.forename: Idris
authors.initials: I
authors.lastname: Yucel
keywords: breast cancer; metastasis; prognostic factor; thyroid peroxidase antibodies