title: Scopolamine attenuates auditory cortex response.
abstract: CONCLUSIONS
  Scopolamine, a tropane alkaloid drug that mainly acts as an antagonist of muscarinic acetylcholine receptors, was found to reduce the local field potentials (LFP) of auditory cortex (AC) evoked by tone and gap-offsets whose effects may compensate the cortical hyperexcitability related to tinnitus.
  
  
  OBJECTIVE
  To study the effects of scopolamine on the AC and the inferior colliculus (IC) of awake rats in order to understand scopolamine's effect on tinnitus and gap detection.
  
  
  METHODS
  Silent gaps (duration varied from 2-100 ms) embedded in otherwise continuous noise were used to elicit AC and IC response. Gap evoked AC and IC field potentials were recorded from awake rats before and after treatment of scopolamine (3 mg/kg, i.m.).
  
  
  RESULTS
  Acute injection of scopolamine (3 mg/kg, i.m.) induced a significant reduction of the AC response, but not the IC response, to the offset of the gaps embedded in white noise. The results suggest that scopolamine may reduce AC neural synchrony.
authors.affiliation: a 1 Department of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Third Military Medical University , Chongqing, PR China.
authors.forename: Anchun
authors.initials: A
authors.lastname: Deng
authors.affiliation: a 1 Department of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Third Military Medical University , Chongqing, PR China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Liang
authors.affiliation: b 2 Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo , Buffalo, NY, USA.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Sun
authors.affiliation: a 1 Department of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Third Military Medical University , Chongqing, PR China.
authors.forename: Yanghong
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: a 1 Department of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Third Military Medical University , Chongqing, PR China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Yang
authors.affiliation: a 1 Department of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Third Military Medical University , Chongqing, PR China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yan
authors.affiliation: b 2 Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo , Buffalo, NY, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects* / Q000503:physiopathology; D001309:Auditory Threshold; D004567:Electrodes, Implanted; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D007245:Inferior Colliculi; D007267:Injections; D008297:Male; D018727:Muscarinic Antagonists / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine / Q000008:administration & dosage*; D014012:Tinnitus / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D018727:Muscarinic Antagonists; D012601:Scopolamine
keywords: Scopolamine; acetylcholine; auditory cortex; gap detection; tinnitus