title: F18-FDG-PET for recurrent differentiated thyroid cancer: a systematic meta-analysis.
abstract: BACKGROUND
  Positron emission tomography (PET) with fluor-18-deoxy-glucose (FDG) is widely used for diagnosing recurrent or metastatic disease in patients with differentiated thyroid cancer (DTC).
  
  
  OBJECTIVE
  To assess the diagnostic accuracy of FDG-PET for DTC in patients after ablative therapy.
  
  
  METHODS
  A systematic search was conducted in Medline/PubMed, EMBASE, Cochrane Library, Web of Science, and Open Grey looking for all English-language original articles on the performance of FDG-PET in series of at least 20 patients with DTC having undergone ablative therapy including total thyroidectomy. Diagnostic performance measures were pooled using Reitsma's bivariate model.
  
  
  RESULTS
  Thirty-four publications between 1996 and 2014 met the inclusion criteria. Pooled sensitivity and specificity were 79.4% (95% confidence interval [CI], 73.9-84.1) and 79.4% (95% CI, 71.2-85.4), respectively, with an area under the curve of 0.858.
  
  
  CONCLUSIONS
  F18-FDG-PET is a useful method for detecting recurrent DTC in patients having undergone ablative therapy.
authors.affiliation: Nuclear Medicine/PET-Center, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Torjan
authors.initials: T
authors.lastname: Haslerud
authors.affiliation: Section for Endocrine Surgery, Haukeland University Hospital, Bergen, Norway.
authors.forename: Katrin
authors.initials: K
authors.lastname: Brauckhoff
authors.affiliation: Section for Oncological Imaging, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Lars
authors.initials: L
authors.lastname: Reisæter
authors.affiliation: Medical and Dental Library, University of Bergen, Bergen/Norway.
authors.forename: Regina
authors.initials: R
authors.lastname: Küfner Lein
authors.affiliation: Institute of Biostatistics and Clinical Research, University of Münster, Münster/Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Heinecke
authors.affiliation: Section for Oncological Imaging, Department of Radiology, Haukeland University Hospital, Bergen, Norway Department of Clinical Science, University of Bergen, Bergen/Norway.
authors.forename: Jan Erik
authors.initials: JE
authors.lastname: Varhaug
authors.affiliation: Nuclear Medicine/PET-Center, Department of Radiology, Haukeland University Hospital, Bergen, Norway Department of Clinical Medicine, University of Bergen, Bergen/Norway martin.biermann@uib.no.
authors.forename: Martin
authors.initials: M
authors.lastname: Biermann
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Head/neck; PET-CT; neoplasms; thyroid