title: The crosstalk between acinar cells withKrasmutations and M1-polarized macrophages leads to initiation of pancreatic precancerous lesions.
abstract: Recent studies on the processes that lead to the development of pancreatic cancer indicate that inflammatory macrophages have key functions in the initiation of pre-neoplastic lesions. Specifically, acquisition of an activatingKrasmutation in pancreatic acinar cells leads to upregulation of intercellular adhesion molecule-1 (ICAM-1), which serves as a chemoattractant for M1-polarized macrophages. M1 macrophages then contribute to acinar cell metaplasia and development of precancerous lesions through inflammatory cytokines and secreted proteases.
authors.affiliation: Department of Cancer Biology; Mayo Clinic Comprehensive Cancer Center; Mayo Clinic ; Jacksonville, FL, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Storz
keywords: Kras; PanIN; acinar-to-ductal metaplasia; inflammation; macrophages; pancreas; pancreatic cancer; pancreatitis