title: Aspp1: A Guardian of Hematopoietic Stem Cell Integrity.
abstract: Eliminating hematopoietic stem cells (HSCs) with DNA damage is necessary to maintain the homeostasis of HSCs, but the mechanisms underlying this apoptotic elimination are unclear. Now in Cell Stem Cell, Yamashita et al. (2015) show that Aspp1 coordinates with p53 to protect HSC pool integrity, guarding against hematological malignancies.
authors.affiliation: Ludwig Institute for Cancer Research, University of Oxford, OX3 7DQ, Oxford, UK.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Zak
authors.affiliation: Ludwig Institute for Cancer Research, University of Oxford, OX3 7DQ, Oxford, UK. Electronic address: xin.lu@ludwig.ox.ac.uk.
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D002471:Cell Transformation, Neoplastic; D006412:Hematopoietic Stem Cells / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing