title: Higher plasma prorenin concentration plays a role in the development of coronary artery disease.
abstract: BACKGROUND
  Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to examine the relationships among plasma prorenin concentration, CAD and clinical parameters.
  
  
  METHODS
  We measured plasma prorenin and renin concentrations and other parameters in 85 patients who underwent coronary angiography. Patients were divided into a CAD group (≥75 % stenosis in one or more coronary arteries) and a non-CAD group.
  
  
  RESULTS
  There was a weak correlation between prorenin and plasma renin concentration (r =0.35, p =0.001), and plasma renin activity (r =0.34, p =0.001). There was no significant difference in the plasma prorenin concentration between the CAD group and non-CAD group. However, patients with a high plasma prorenin concentration frequently suffered CAD. Receiver-operating-characteristic curve analysis showed that the optimal cutoff value of plasma prorenin concentration to detect CAD was 1,100 pg/ml, with a positive predictive value of 94 % and a negative predictive value of 36 %.
  
  
  CONCLUSIONS
  The plasma prorenin concentration increases with increases in plasma renin concentration. Higher plasma prorenin concentration (>1,100 pg/ml) plays a role in the development of CAD.
authors.affiliation: Department of Nephrology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Gakuro
authors.initials: G
authors.lastname: Yoshida
authors.affiliation: Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194 Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Kawasaki
authors.affiliation: Department of Nephrology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Ichijiro
authors.initials: I
authors.lastname: Murata
authors.affiliation: Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194 Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Hayakawa
authors.affiliation: Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194 Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Aoyama
authors.affiliation: Department of Nephrology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Nagisa
authors.initials: N
authors.lastname: Miyazaki
authors.affiliation: Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194 Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194 Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nishigaki
authors.affiliation: Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Arai
authors.affiliation: Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Suzuki
authors.affiliation: Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194 Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Minatoguchi
keywords: Coronary artery disease; Prorenin; Renin