title: Promoting Kidney Function Recovery in Patients with AKI Requiring RRT.
abstract: AKI requiring RRT is associated with high mortality, morbidity, and long-term consequences, including CKD and ESRD. Many patients never recover kidney function; in others, kidney function improves over a period of many weeks or months. Methodologic constraints of the available literature limit our understanding of the recovery process and hamper adequate intervention. Current management strategies have focused on acute care and short-term mortality, but new data indicate that long-term consequences of AKI requiring RRT are substantial. Promotion of kidney function recovery is a neglected focus of research and intervention. This lack of emphasis on recovery is illustrated by the relative paucity of research in this area and by the lack of demonstrated effective management strategies. In this article the epidemiologic implications of kidney recovery after AKI requiring RRT are discussed, the available literature and its methodologic constraints are reviewed, and strategies to improve the understanding of factors that affect kidney function recovery are proposed. Measures to promote kidney function recovery are a serious unmet need, with a great potential to improve short- and long-term patient outcomes.
authors.affiliation: Department of Medicine, Division of Nephrology, Albany Medical College, Albany, New York; cerdaj@mail.amc.edu cerda@nycap.rr.com.
authors.forename: Jorge
authors.initials: J
authors.lastname: Cerdá
authors.affiliation: Division of Nephrology, Department of Medicine University of California, San Francisco, San Francisco, California.
authors.forename: Kathleen D
authors.initials: KD
authors.lastname: Liu
authors.affiliation: Department of Medicine, Division of Nephrology, University of California San Diego, San Diego, California;
authors.forename: Dinna N
authors.initials: DN
authors.lastname: Cruz
authors.affiliation: Department of Medicine, St. Elizabeth's Medical Center Tufts University School of Medicine, Boston, Massachussetts;
authors.forename: Bertrand L
authors.initials: BL
authors.lastname: Jaber
authors.affiliation: Department of Nephrology, University of Chicago, Chicago, Illinois;
authors.forename: Jay L
authors.initials: JL
authors.lastname: Koyner
authors.affiliation: Department of Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan;
authors.forename: Michael
authors.initials: M
authors.lastname: Heung
authors.affiliation: Department of Medicine, University of Virginia, Charlottesville, Virginia; and.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Okusa
authors.affiliation: Department of Medicine, Division of Nephrology, University of Colorado Denver, Denver, Colorado.
authors.forename: Sarah
authors.initials: S
authors.lastname: Faubel
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D000925:Anticoagulants / Q000008:administration & dosage; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D020127:Recovery of Function; D017582:Renal Replacement Therapy / Q000379:methods; D015996:Survival Rate; D013997:Time Factors; D014882:Water-Electrolyte Balance
chemical_list: D000925:Anticoagulants
keywords: AKI; RRT; kidney function recovery; progression of renal failure; survival