title: Modulating gut immunity and neoplasia with oral cytokine adjuvants.
abstract: Oral administration of particulate IL-10 suppressed polyposis, ameliorated systemic pathology and extended lifespan in APCmin/+mice. Therapeutic effect was associated with selective activity of IL-10 on intestinal CD4+Foxp3+RORγt+IL-17+ pathogenic T-regulatory cells. Studies were recently extended to a bacterially-driven murine colon adenocarcinoma model with similar results. Clinical implications of these findings are discussed.
authors.affiliation: Department of Pharmaceutical Microbiology; Erciyes University School of Medicine ; Kayseri, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Ozbilge
authors.affiliation: Department of Surgical Pathology; Roswell Park Cancer Institute ; Buffalo, NY USA.
authors.forename: Charles
authors.initials: C
authors.lastname: LeVea
authors.affiliation: School of Medicine and Biomedical Sciences; University at Buffalo ; Buffalo, NY USA.
authors.forename: Allen Y
authors.initials: AY
authors.lastname: Chung
authors.affiliation: Department of Microbiology and Immunology; University of Louisville School of Medicine ; Louisville, KY USA.
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Microbiology and Immunology; University of Louisville School of Medicine ; Louisville, KY USA.
authors.forename: Nejat K
authors.initials: NK
authors.lastname: Egilmez
keywords: bioerodible microparticles; cancer; gastrointestinal tract; immune therapy; inflammation; oral cytokine