title: Orbital Compartment Syndrome as the Presenting Sign of Disseminated Intravascular Coagulation From Metastatic Prostatic Cancer to the Orbit.
abstract: A 70-year-old man with castrate-resistant metastatic prostate cancer to the lumbar spine presented with sudden onset of left orbital compartment syndrome. Hematologic workup revealed disseminated intravascular coagulation with isolated left orbital hemorrhage. A canthotomy and blood product transfusions failed to control the bleeding and restore vision. Operative intervention found a new left orbital roof metastasis from primary prostatic carcinoma. Acute onset of headache or ocular pain in patients with metastatic prostate cancer warrants further workup to rule out orbital and intracranial metastases, rare but significant clinical entities that can lead to severe complications.
authors.affiliation: Department of Urology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA. Electronic address: Hong.Truong@jefferson.edu.
authors.forename: Hong
authors.initials: H
authors.lastname: Truong
authors.affiliation: Department of Urology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
authors.forename: May Jean
authors.initials: MJ
authors.lastname: Counsilman
authors.affiliation: Division of Hematology, Department of Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
authors.forename: Mahasweta
authors.initials: M
authors.lastname: Gooptu
authors.affiliation: Division of Hematology, Department of Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pulte
authors.affiliation: Department of Pathology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Prestipino
authors.affiliation: Department of Urology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
authors.forename: Costas D
authors.initials: CD
authors.lastname: Lallas
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000556:secondary*; D000368:Aged; D003161:Compartment Syndromes / Q000209:etiology*; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D009916:Orbital Diseases / Q000209:etiology*; D009918:Orbital Neoplasms / Q000150:complications* / Q000556:secondary*; D011471:Prostatic Neoplasms / Q000473:pathology*