title: Collective cell migration: guidance principles and hierarchies.
abstract: Collective cell migration results from the establishment and maintenance of collective polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell migration depends on a reciprocal process between cell-intrinsic multicellular organization with leader-follower cell behavior and results in mechanosensory integration of extracellular guidance cues. Important guidance mechanisms include chemotaxis, haptotaxis, durotaxis, and strain-induced mechanosensing to move cell groups along interfaces and paths of least resistance. Additional guidance mechanisms steering cell groups during specialized conditions comprise electrotaxis and passive drift. To form higher-order cell and tissue structures during morphogenesis and cancer invasion, these guidance principles act in parallel and are integrated for collective adaptation to and shaping of varying tissue environments. We review mechanochemical and electrical inputs and multiparameter signal integration underlying collective guidance, decision making, and outcome.
authors.affiliation: Radboud Institute for Molecular Life Sciences, Department of Cell Biology, Post 283, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Anna
authors.initials: A
authors.lastname: Haeger
authors.affiliation: Radboud Institute for Molecular Life Sciences, Department of Cell Biology, Post 283, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Katarina
authors.initials: K
authors.lastname: Wolf
authors.affiliation: Radboud Institute for Molecular Life Sciences, Department of Cell Biology, Post 283, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Mirjam M
authors.initials: MM
authors.lastname: Zegers
authors.affiliation: Radboud Institute for Molecular Life Sciences, Department of Cell Biology, Post 283, PO Box 9101, 6500 HB Nijmegen, The Netherlands; UT MD Anderson Cancer Center, Genitourinary Medical Oncology - Research, Houston, TX, USA; Cancer Genomics Network Netherlands (http://www.cancergenomics.nl). Electronic address: Peter.Friedl@radboudumc.nl.
authors.forename: Peter
authors.initials: P
authors.lastname: Friedl
mesh_terms: D000818:Animals; D002465:Cell Movement; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology; D040542:Mechanotransduction, Cellular
keywords: collective migration; extracellular matrix; guidance cues; leader cells; mechanocoupling; signal integration