title: The role of autophagy in bacterial infections.
abstract: Autophagy is a highly conserved catabolic process for the degradation of cytosolic components including damaged organelles, protein aggregates, and intracellular bacteria through a lysosome-dependent pathway. Autophagy can be induced in response to stress conditions. Furthermore, autophagy has been described as involved in both innate and adaptive immune responses, and several studies have shown that certain microorganisms can be eliminated by the autophagic route in a process known as xenophagy. However, several pathogens have developed different strategies to evade or exploit autophagy to ensure their survival. Here, we review the role of autophagy in response to bacterial pathogens.
authors.affiliation: Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N.
authors.forename: Nayeli Shantal
authors.initials: NS
authors.lastname: Castrejón-Jiménez
authors.forename: Kahiry
authors.initials: K
authors.lastname: Leyva-Paredes
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Hernández-González
authors.forename: Julieta
authors.initials: J
authors.lastname: Luna-Herrera
authors.forename: Blanca Estela
authors.initials: BE
authors.lastname: García-Pérez
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D001424:Bacterial Infections / Q000382:microbiology* / Q000503:physiopathology*; D016997:Coxiella burnetii; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D016952:Legionella pneumophila; D008089:Listeria monocytogenes; D008247:Lysosomes / Q000378:metabolism; D009169:Mycobacterium tuberculosis; D016966:Porphyromonas gingivalis; D012486:Salmonella typhimurium; D012763:Shigella flexneri; D013297:Streptococcus pyogenes