title: Developmental Coordination Disorder in Children with a History of Infantile Colic.
abstract: OBJECTIVE
  To investigate whether children with a history of infantile colic showed impaired motor development at age 7 years compared with unaffected peers.
  
  
  METHODS
  We studied 27,940 children from the Danish National Birth Cohort (1997-2002), including 1879 (6.8%) with a history of infantile colic. Infantile colic was defined according to the modified Wessel criteria as crying for more than 3 hours per day and more than 3 days per week. We compared the parental Developmental Coordination Disorder Questionnaire 2007 (DCDQ'07) scores in children with and without infantile colic after adjustment for intrauterine exposures, feeding type, parity, maternal age, socioeconomic status, Apgar score, gestational age, and birth weight.
  
  
  RESULTS
  Children with a history of infantile colic had an elevated risk of scoring above the predefined cutoff limit of possible or suspected developmental coordination disorder (OR, 1.3; 95% CI, 1.0-1.7; P = .034). The mean total DCDQ'07 score was -0.4 point (95% CI, -0.8 to 0) lower in children with a history of infantile colic. Moreover, they were at higher risk for a low total score (OR for a 10-point decrease, 1.1; 95% CI, 1.0-1.1; P = .006) and a low general coordination score (OR, 1.3; 95% CI, 1.1-1.5, P = .000) in the DCDQ'07. All associations appeared to be stronger among boys, but no statistically significant effect measure modification between infantile colic and sex was found.
  
  
  CONCLUSIONS
  We found no evidence of a strong association between infantile colic and developmental coordination disorder in this large Danish cohort.
authors.affiliation: Perinatal Epidemiology Research Unit, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark. Electronic address: ioanna.milidou@clin.au.dk.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Milidou
authors.affiliation: Perinatal Epidemiology Research Unit, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Morten Søndergaard
authors.initials: MS
authors.lastname: Lindhard
authors.affiliation: Department of Pediatrics, Herning Regional Hospital, Herning, Denmark.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Søndergaard
authors.affiliation: Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Jørn
authors.initials: J
authors.lastname: Olsen
authors.affiliation: Perinatal Epidemiology Research Unit, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark; Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Tine Brink
authors.initials: TB
authors.lastname: Henriksen
mesh_terms: D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003085:Colic / Q000453:epidemiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D019957:Motor Skills Disorders / Q000453:epidemiology*; D012044:Regression Analysis; D012737:Sex Factors