title: Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients.
abstract: BACKGROUND
  The aim of this study was to investigate the expression of Paxillin in colorectal carcinoma and its significance in clinical prognosis.
  
  
  METHODS
  Tissue specimens from 242 colorectal cancer patients who underwent radical resection were collected in Shaanxi Provincial People's Hospital from 2010 to 2014. The mRNA levels of Paxillin in colorectal cancer tissue and tissue adjacent to carcinoma of 62 patients were measured by quantitative real-time PCR. Immunohistochemistry staining was used to detect the expression of Paxillin in 242 samples of paraffin-embedded tissues.
  
  
  RESULTS
  The mRNA and protein level of Paxillin in colorectal cancer tissues were significantly higher than those in the tissue adjacent to carcinoma (P<0.001 and P=0.003, respectively). The expression of Paxillin was significantly correlated to tumor histological grade (P<0.001), tumor size (P=0.01), serum CA199 level (P<0.001), the clinical TNM stage (P<0.001), and distant metastasis (P<0.001). Survival analysis showed that the prognosis of the patients with high expression of Paxillin was poorer than those with low expression of Paxillin (P=0.03). Cox proportional hazards model with stepwise selection showed that age, Paxillin expression level, and the clinical TNM stage were independent prognostic factors influencing survival for patients (P=0.01, P=0.004 and P<0.001, respectively).
  
  
  CONCLUSIONS
  Paxillin was expressed at significantly higher levels in colorectal cancer tissues and might serve as a potential prognostic indicator in patients with colorectal cancer.
authors.affiliation: Department of Emergency, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China (mainland).
authors.forename: Cheng-jin
authors.initials: CJ
authors.lastname: Zhao
authors.affiliation: Department of Emergency, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China (mainland).
authors.forename: Shuang-kuan
authors.initials: SK
authors.lastname: Du
authors.affiliation: Department of Emergency, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China (mainland).
authors.forename: Xing-bo
authors.initials: XB
authors.lastname: Dang
authors.affiliation: Department of Ophthalmology, Union Hospital of Hua Zhong University of Science and Technology, Wuhan, Hubei, China (mainland).
authors.forename: Min
authors.initials: M
authors.lastname: Gong
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051419:Paxillin / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D051419:Paxillin