title: Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors.
abstract: OBJECTIVE
  The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation-tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (CV) risk factors (diabetes, dyslipidemia and arterial hypertension).
  
  
  METHODS
  Twenty-five young women with PCOS and 23 eumenorrheic women without major CV risk factors and matched for body mass index (BMI) were studied. They were subdivided according to BMI and PCOS status and comparisons were made between the PCOS and Control groups, regardless of BMI, and between the Obese and Lean groups, regardless of the presence of PCOS.
  
  
  RESULTS
  Levels of TNF-α, IL-6 and hsCRP were similar between the PCOS group and the Control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-α were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hsCRP were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively).
  
  
  CONCLUSIONS
  Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major CV risk factors.
authors.affiliation: Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
authors.forename: Cristiano Roberto
authors.initials: CR
authors.lastname: Barcellos
authors.affiliation: Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
authors.forename: Michelle Patrocínio
authors.initials: MP
authors.lastname: Rocha
authors.affiliation: Gynecology Unit, University of Sao Paulo, School of Medicine, Brazil.
authors.forename: Sylvia Asaka
authors.initials: SA
authors.lastname: Hayashida
authors.affiliation: Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
authors.forename: Wagner Silva
authors.initials: WS
authors.lastname: Dantas
authors.affiliation: Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
authors.forename: Viviane
authors.initials: V
authors.lastname: Dos Reis Vieira Yance
authors.affiliation: Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Marcondes
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood*; D009765:Obesity / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein