title: The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
abstract: As an intracellular polypeptide, heat shock protein 70 (HSP70) can be exposed on the plasma membrane and/or released into the circulation. However, the role of HSP70 in various nondisease and disease conditions remains unknown. Quantitative methods for the detection of HSP70 have been used in clinical studies, revealing that an increase in circulating HSP70 is associated with various types of exercise, elderly patients presenting with inflammation, mobile phones, inflammation, sepsis, chronic obstructive pulmonary disease, asthma, carotid intima-media thickness, glutamine-treated ill patients, mortality, diabetes mellitus, active chronic glomerulonephritis, and cancers. Circulating HSP70 decreases with age in humans and in obstructive sleep apnea, arteriosclerosis, atrial fibrillation (AF) following coronary artery bypass surgery, nonalcoholic fatty liver disease, moderate-to-severe alcoholic fatty liver disease, hepatic steatosis, and Helicobacter pylori infection. In conclusion, quantitative methods can be used to detect HSP70, particularly in determining circulating HSP70 levels, using more convenient and rapid screening methods. Studies have shown that changes in HSP70 are associated with various nondisease and disease conditions; thus, HSP70 might be a novel potential biomarker reflecting various nondisease conditions and also the severity of disease conditions. However, the reliability and accuracy, as well as the underlying mechanism, of this relationship remain poorly understood, and large-sample clinical research must be performed to verify the role.
authors.affiliation: Internal Medicine, Taishan Hospital, No. 3 Tianwaicun Street, Taian City, Shandong, 271000, People's Republic of China. qubaoge@sina.com.
authors.forename: Baoge
authors.initials: B
authors.lastname: Qu
authors.affiliation: Internal Medicine, Taishan Hospital, No. 3 Tianwaicun Street, Taian City, Shandong, 271000, People's Republic of China.
authors.forename: Yiguo
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Internal Medicine, Taishan Hospital, No. 3 Tianwaicun Street, Taian City, Shandong, 271000, People's Republic of China.
authors.forename: Yuanxun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Internal Medicine, Taishan Hospital, No. 3 Tianwaicun Street, Taian City, Shandong, 271000, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Internal Medicine, Taishan Hospital, No. 3 Tianwaicun Street, Taian City, Shandong, 271000, People's Republic of China.
authors.forename: Guangying
authors.initials: G
authors.lastname: Ren
authors.affiliation: Internal Medicine, Taishan Hospital, No. 3 Tianwaicun Street, Taian City, Shandong, 271000, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male
chemical_list: D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins
keywords: Biomarkers; Disease conditions; Heat shock protein 70; Inflammation; Nondisease conditions