title: SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity.
abstract: Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
authors.forename: Dawid
authors.initials: D
authors.lastname: Lewandowski
authors.affiliation: Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ruszkowski
authors.affiliation: Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Anita
authors.initials: A
authors.lastname: Pińska
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Schroeder
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kurczewska
mesh_terms: D000327:Adsorption; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005707:Gallic Acid / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D009942:Organometallic Compounds; C509969:SBA-15; D005707:Gallic Acid; D012822:Silicon Dioxide