title: p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis.
abstract: OBJECTIVE
  There are conflicting data regarding immunohistochemical expression of p53 in pleomorphic adenoma. This systematic review and meta-analysis aimed to examine whether p53 expression has a role in the pathogenesis of pleomorphic adenoma.
  
  
  METHODS
  A comprehensive literature search for relevant studies published from 2000 up to end of 2014 was performed using PubMed, EMBASE and the Cochrane Library Databases. Only articles in which p53 detected by immunohistochemical staining were included. The meta-analysis was done using Comprehensive Meta-Analysis software.
  
  
  RESULTS
  Eighteen eligible studies were included in this meta-analysis. Heterogeneity measures showed a statistically significant Cochrane Q value (P-value<0.001). The random effects model showed an effect size of 0.254 with a 95% CI (0.139-0.417). The overall p53 positivity is 25.4%.
  
  
  CONCLUSIONS
  Mutant p53 has to be detected by more precise techniques to emphasize on its role in development of pleomorphic adenoma of salivary gland.
authors.affiliation: Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia; Department of Oral Medicine and Pathology, Faculty of Dentistry, Sana'a University, Yemen. Electronic address: dr2007nader@yahoo.com.
authors.forename: Nader Ahmed
authors.initials: NA
authors.lastname: Alaizari
authors.affiliation: Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia.
authors.forename: Bassel
authors.initials: B
authors.lastname: Tarakji
authors.affiliation: Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia; Department of Oral Medicine and Pathology, Faculty of Dentistry, Sana'a University, Yemen.
authors.forename: Sadeq Ali
authors.initials: SA
authors.lastname: Al-Maweri
authors.affiliation: Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia.
authors.forename: Hashem Motahir
authors.initials: HM
authors.lastname: Al-Shamiri
authors.affiliation: Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia.
authors.forename: Shourouk
authors.initials: S
authors.lastname: Darwish
authors.affiliation: Aleppo University, Faculty of Dentistry, Syria.
authors.forename: Feras
authors.initials: F
authors.lastname: Baba
mesh_terms: D008949:Adenoma, Pleomorphic / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D012468:Salivary Gland Neoplasms / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53
keywords: Immunohistochemical; Meta-analysis; Pleomorphic adenoma; Systemic review; p53