title: The use of solid lipid nanoparticles for sustained drug release.
abstract: Novel solid lipid drug delivery systems such as solid lipid nanoparticles (SLN) have attracted wide and increasing attention in recent years. It has been sought as an interesting alternative drug delivery carrier system for bioactives for a variety of delivery routes. They show major advantages such as sustained release, improved bioavailability, improved drug incorporation and very wide application. This paper presents a discussion on the production protocols of SLN, lyophilization of SLN and delivery of SLN across the blood-brain barrier. Special attention was also paid to entrapment and release of drugs from SLN and strategies to enhance drug entrapment in SLN for sustained release. Analytical methods for the characterization of SLN were also discussed. Various routes of administration of SLN were presented as well as a consideration of the ethical issues and future prospects in the production and use of SLN for sustained release of bioactives.
authors.affiliation: Drug Delivery & Nanomedicines Research Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.|Nanomedicine & Drug Delivery Research Unit, Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra State, Nigeria.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Attama
authors.affiliation: Nanomedicine & Drug Delivery Research Unit, Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra State, Nigeria.
authors.forename: Chukwuebuka E
authors.initials: CE
authors.lastname: Umeyor
mesh_terms: D001812:Blood-Brain Barrier / Q000378:metabolism*; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D004333:Drug Administration Routes; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D065546:Drug Liberation; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008055:Lipids; D013501:Surface-Active Agents