title: Red selenium nanoparticles and gray selenium nanorods as antibacterial coatings for PEEK medical devices.
abstract: Bacterial infections are commonly found on various poly(ether ether ketone) (PEEK) medical devices (such as orthopedic instruments, spinal fusion devices, and segments in dialysis equipment), and thus, there is a significant need for introducing antibacterial properties to such materials. The objective of this in vitro study was to introduce antibacterial properties to PEEK medical devices by coating them with nanosized selenium. In this study, red selenium (an elemental form of selenium) nanoparticles were coated on PEEK medical devices through a quick precipitation method. Furthermore, with heat treatment at 100°C for 6 days, red selenium nanoparticles were transferred into gray selenium nanorods on the PEEK surfaces. Bacteria test results showed that both red and gray selenium-coated PEEK medical devices significantly inhibited the growth of Pseudomonas aeruginosa compared with uncoated PEEK after either 1, 2, or 3 days. Red selenium nanoparticle-coated PEEK showed less bacteria growth on its surface than gray selenium nanorod-coated PEEK after 3 days. This study demonstrated that red, and to a lesser extent gray, nanosized selenium could be used as potential antibacterial coatings to prevent bacteria function on PEEK medical devices. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1352-1358, 2016.
authors.affiliation: Department of Bioengineering, College of Engineering, Northeastern University, Boston, Massachusetts, 02115.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Bioengineering, University of Antioquia, Medellín, Antioquia, Colombia.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Mejía Jaramillo
authors.affiliation: Department of Bioengineering, University of Antioquia, Medellín, Antioquia, Colombia.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Pavon
authors.affiliation: Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, Massachusetts, 02115. th.webster@neu.edu.|Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia. th.webster@neu.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Webster
mesh_terms: D001577:Benzophenones; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers; D011550:Pseudomonas aeruginosa / Q000254:growth & development*; D012643:Selenium / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D020099:Coated Materials, Biocompatible; D007659:Ketones; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols; D012643:Selenium
keywords: PEEK medical devices; antibacterial; gray selenium nanorods; red selenium nanoparticles