title: [Whole-body diffusion-weighted magnetic resonance imaging by estimating the measurable diffusion coefficient in Hodgkin Iymphoma].
abstract: OBJECTIVE
  To determine whether the measurable diffusion coefficient (MIC) may be used to differentiate normal and lymphomatosis-altered lymph nodes (LNs) in patients with Hodgkin lymphoma (HL).
  
  
  METHODS
  Whole-body magnetic resonance (MR) imaging was used to compare the MICs of LNs in 27 apparently healthy individuals and 41 patients with a verified diagnosis of HL.
  
  
  RESULTS
  Construction of 95% confidence intervals showed that the MICs of normal LNs were in the range of 1.00 to 1.73 x x10(-3) mm2/sec and significantly higher (p < 0.05) than those of lymphomatosis-affected LNs (MIC, 0.59 to 0.94 x 10(-3) mm2/sec). The cut-off point (for discretization) of normal and lymphomatosis-altered LNs was in the range of 0.94 to 1.00 x 10(-3) mm2/sec. Consequently, the LN with a MIC of less than 0.94 x 10(-3) mm2/sec may be thought of as affected by the lymphomatous process.
  
  
  CONCLUSIONS
  MIC calculation permits differentiation of normal and affected LNs having equal signal characteristics (including those on diffusion-weighted MR images).
authors.forename: A I
authors.initials: AI
authors.lastname: Mikhaĭlov
authors.forename: V O
authors.initials: VO
authors.lastname: Panov
authors.forename: I E
authors.initials: IE
authors.lastname: Tiurin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult