title: Relationship Between Mean Platelet Volume and Pulmonary Embolism in Patients With Deep Vein Thrombosis.
abstract: BACKGROUND
  Mean platelet volume (MPV) has been demonstrated to be associated with deep vein thrombosis (DVT). However, its role in the prediction of pulmonary embolism (PE), which is a major complication of DVT, is still unclear. Therefore, we investigated the association of MPV values with acute PE in patients with DVT.
  
  
  METHODS
  The study included three groups: patients with DVT and PE (n=98); patients with DVT without PE (n=97); and control group (No DVT, No PE, n=98). We also evaluated DVT patients according to the MPV values on admission and categorised them into two groups: MPV≤9.15 fL (n=82) and MPV>9.15 fL (n=113).
  
  
  RESULTS
  MPV was significantly higher in all DVT patients than controls (9.3±0.9 fL vs 7.9±0.7 fL, p<0.001) and in DVT patients with PE than DVT patients without PE (9.9±0.6 fL vs 8.7±0.7 fL, p<0.001). The rate of PE was higher in patients with DVT with MPV>9.15 fL than those with MVP≤9.15 fL (75.2% vs 15.9%, p<0.001). The presence of PE in patients with DVT was independently associated with MPV (OR: 22.19, 95%CI: 9.39-53.19, P<0.001).
  
  
  CONCLUSIONS
  Although our findings should be considered within the limitations of the study, they suggest that MPV measures may be elevated in DVT patients and a higher MPV may be associated with PE in patients with DVT.
authors.affiliation: Department of Cardiology, Ahi Evran University Faculty of Medicine, Kirsehir, Turkey. Electronic address: atillaicli@hotmail.com.
authors.forename: Atilla
authors.initials: A
authors.lastname: Icli
authors.affiliation: Department of Cardiology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Aksoy
authors.affiliation: Department of Cardiology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Turker
authors.affiliation: Department of Cardiology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.
authors.forename: Bayram Ali
authors.initials: BA
authors.lastname: Uysal
authors.affiliation: Department of Cardiovascular Surgery, Ahi Evran University Education and Research Hospital, Kirsehir, Turkey.
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Alpay
authors.affiliation: Department of Cardiology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
authors.affiliation: Department of Cardiology, Ahi Evran University Faculty of Medicine, Kirsehir, Turkey.
authors.forename: Gökay
authors.initials: G
authors.lastname: Nar
authors.affiliation: Department of Cardiology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000097:blood / Q000150:complications; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000097:blood / Q000150:complications
keywords: Acute pulmonary embolism; Deep vein thrombosis; Mean platelet volume; Platelet activation; Platelet count