title: Regulation of ROS defense system by Hybanthus enneaspermus in CCl4 induce cardiac damage.
abstract: The purpose of this study is to regulate the ROS (Reactive oxygen species) defense system in cardiac damage induced by CCl₄(Carbon tetra chloride) in rats using Hybanthus enneaspermus. Administration of CCl₄induces damage in the heart of rats as proved by estimation of antioxidant enzymes such as, SOD (Superoxide dismutase), CAT (catalase), GPx (Glutathione Peroxdiase), GR (Glutathione Reductase), GST (Glutathione-S-Transferaes). However, treatment with HEE in CCl₄intoxicated rats was found to be protected the heart, as indicated by the enzyme level in serum. A significant increment of serum enzymes level such as SOD, CAT, GPx, GR and GST were observed following HEE treatment during CCl₄intoxication whereas MDA (Malondialdehyde) level in HEE treated rats were decreased. The results of our experiment suggest that the treatment of HEE may be the critical remedy for the adverse effect of CCl₄in heart function.
authors.affiliation: Department of Biochemistry and Chemistry, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Thirupathi
authors.affiliation: Department of Biochemistry and Chemistry, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.
authors.forename: Kalaiselvan
authors.initials: K
authors.lastname: Ashokan
authors.affiliation: Department of Biochemistry and Chemistry, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.
authors.forename: Shanmugavadivelu
authors.initials: S
authors.lastname: ChandraMohan
authors.affiliation: Department of Mathematics, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.
authors.forename: Balakumar
authors.initials: B
authors.lastname: Rajakrishnan
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D008315:Malondialdehyde / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*; D029649:Violaceae
chemical_list: D010936:Plant Extracts; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D002251:Carbon Tetrachloride