title: Deep Fungal Infections, Blastomycosis-Like Pyoderma, and Granulomatous Sexually Transmitted Infections.
abstract: Granulomatous diseases are caused by multiple infectious and noninfectious causes. Deep fungal infections can present in the skin or extracutaneously, most commonly with lung manifestations. An Azole or amphotericin B is the universal treatment. Blastomycosis-like pyoderma is a clinically similar condition, which is caused by a combination of hypersensitivity and immunosuppression. Successful treatment has been reported with antibiotics and, more recently, the vitamin A analog, acitretin. Granuloma inguinale and lymphogranuloma venereum cause ulcerative genital lesions with a granulomatous appearance on histology. The Centers for Disease Control and Prevention recommens treatment of these genital infections with doxycycline.
authors.affiliation: Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA.
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Guidry
authors.affiliation: Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA. Electronic address: cdowning@ccstexas.com.
authors.forename: Christopher
authors.initials: C
authors.lastname: Downing
authors.affiliation: Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA; Department of Dermatology, University of Texas Health Science Center, 6655 Travis, Suite 600, Houston, TX 77003, USA.
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Tyring
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001393:Azoles / Q000627:therapeutic use; D001759:Blastomycosis / Q000175:diagnosis / Q000188:drug therapy; D003047:Coccidioidomycosis / Q000175:diagnosis / Q000188:drug therapy; D003453:Cryptococcosis / Q000175:diagnosis / Q000188:drug therapy; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy*; D004318:Doxycycline / Q000627:therapeutic use; D006100:Granuloma Inguinale / Q000175:diagnosis / Q000188:drug therapy*; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use; D008219:Lymphogranuloma Venereum / Q000175:diagnosis / Q000188:drug therapy*; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy*; D011711:Pyoderma / Q000175:diagnosis / Q000188:drug therapy; D012749:Sexually Transmitted Diseases / Q000175:diagnosis / Q000188:drug therapy; D013174:Sporotrichosis / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001393:Azoles; D007641:Keratolytic Agents; D000666:Amphotericin B; D017255:Acitretin; D004318:Doxycycline
keywords: Blastomycosis-like pyoderma; Deep mycoses; Donovanosis; Fungal infection; Granuloma inguinale; Granulomatous disease; Lymphogranuloma venereum