title: Renal denervation for treatment of uncontrolled hypertension in an Asian population: results from the Global SYMPLICITY Registry in South Korea (GSR Korea).
abstract: Reports detailing the response of hypertensive patients to renal denervation (RDN) in Asian patients are limited. We evaluated 6- and 12-month outcomes after RDN in an Asian population and compared outcomes to a primarily Caucasian population. The Global SYMPLICITY Registry (GSR) is a prospective, all-comer, worldwide registry that evaluates the safety and effectiveness of RDN and includes the Korean registry substudy (GSR Korea) and a Caucasian subset (GSR Caucasian). Given differences in baseline characteristics among GSR Korea (n=93) as compared with GSR Caucasian (n=169) patients, including lower baseline office systolic blood pressure (SBP), lower body mass index and differences in medications, propensity score adjustment was performed when comparing the change in SBP between subsets. The 6- and 12-month change in SBP in GSR Korea was -19.4±17.2 and -27.2±18.1 mm Hg, respectively (P<0.001 for both vs baseline). GSR Caucasian had a SBP change similar to GSR Korea at 6 months (-20.9±21.4 mm Hg, unadjusted P=0.547, adjusted P=0.998), whereas at 12 months the change was significantly less pronounced (-20.1±23.9 mm Hg, unadjusted P=0.004, adjusted P=0.002). There were no protocol-defined procedure-related adverse events and no chronic adverse events associated with the device in an Asian population. RDN provided a significant reduction in 6- and 12-month office SBP among Asian patients, with a favorable safety profile. The 12-month SBP reduction was larger than that observed in Caucasian patients.
authors.affiliation: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: B-K
authors.initials: BK
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine and Cardiology, Universitätsklinikum des Saarlandes, Homburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Böhm
authors.affiliation: Department of Internal Medicine and Cardiology, Universitätsklinikum des Saarlandes, Homburg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Mahfoud
authors.affiliation: Center of Epidemiology and Clinical Trials, University of Milano-Bicocca, Monza, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mancia
authors.affiliation: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: S
authors.initials: S
authors.lastname: Park
authors.affiliation: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.|Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: M-K
authors.initials: MK
authors.lastname: Hong
authors.affiliation: Division of Cardiology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: H-S
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Division of Interventional Cardiology, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Division of Cardiology, Korea University College of Medicine, Seoul, Korea.
authors.forename: C G
authors.initials: CG
authors.lastname: Park
authors.affiliation: Department of Cardiovascular Medicine, Catholic University of Korea, Seoul, Korea.
authors.forename: K B
authors.initials: KB
authors.lastname: Seung
authors.affiliation: Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: H-C
authors.initials: HC
authors.lastname: Gwon
authors.affiliation: Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam-si, Korea.
authors.forename: D-J
authors.initials: DJ
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Gachon University of Medicine and Science, Incheon, Korea.
authors.forename: T H
authors.initials: TH
authors.lastname: Ahn
authors.affiliation: Cardiovascular Center, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
authors.forename: C J
authors.initials: CJ
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: H M
authors.initials: HM
authors.lastname: Kwon
authors.affiliation: Baker IDI Heart and Diabetes Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Esler
authors.affiliation: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.|Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Y S
authors.initials: YS
authors.lastname: Jang
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D017115:Catheter Ablation / Q000706:statistics & numerical data*; D003714:Denervation / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D012077:Renal Artery / Q000294:innervation*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents