title: Improvement of post-hypoxic action myoclonus with levetiracetam add-on therapy: A case report.
abstract: BACKGROUND
  Chronic post-anoxic myoclonus, also known as Lance-Adams syndrome, may develop following hypoxic brain injury, and is resistant to pharmacological therapy.
  
  
  METHODS
  The patient we presented developed post-anoxic action myoclonus with severe, completely incapacitating myoclonic jerks. Myoclonus did not respond to the treatment with commonly used agents, i.e. valproate and clonazepam alone or in combination. Improvement of the action myoclonus was observed only after adding levetiracetam.
  
  
  CONCLUSIONS
  Although Lance-Adams syndrome may not be fully curable at this point, levetiracetam appears to be a promising agent that can significantly improve functional level and overall quality of life of patients with this disorder.
authors.forename: Ksenija
authors.initials: K
authors.lastname: Božić
authors.forename: Ksenija
authors.initials: K
authors.lastname: Gebauer-Bukurov
authors.forename: Lorand
authors.initials: L
authors.lastname: Sakalaš
authors.forename: Ivana
authors.initials: I
authors.lastname: Divjak
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Ješić
mesh_terms: D000063:Accidents, Traffic; D000927:Anticonvulsants / Q000627:therapeutic use*; D004569:Electroencephalography; D005593:Fracture Fixation, Internal / Q000009:adverse effects; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000188:drug therapy* / Q000209:etiology; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015050:Zygoma / Q000293:injuries / Q000601:surgery
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam