title: In Vitro Anticancer Activity of the Crude Extract and two Dicinnamate Isolates from the Jamaican Ball Moss (Tillandsia Recurvata L.).
abstract: A crude chloroform extract from the Jamaican Ball Moss (Tillandsia recurvata L.) was tested for activity against three human cancer cell lines including; A375 (human melanoma), MCF-7 (human breast) and PC-3 (human prostate cancer) using the WST-1 assay. IC50s obtained against these cell lines; A375, MCF-7 and PC-3 in the presence of the crude extract are; 0.9μg/ml, 40.51μg/ml and 5.97μg/ml respectively indicating the promising anti-cancer activity of the ball moss extract. Further, preliminary phytochemical study was conducted in an attempt to identify and isolate the phytochemicals that could possibly be responsible for the observed bioactivity of the ball moss chloroform extract. As a result, two dicinnamates were isolated; 1,3-di-O-Cinnamoyl-glycerol (1) and (E)-3-(cinnamoyloxy)-2-hydroxypropyl 3-(3,4-dimethoxyphenyl)acrylate (2) and we report for the first time isolation of compound2. Even though the bioactivity of these two islaotes were fairly weak against the cell lines, the results presented here will prove useful for further research aimed at identifying molecules that maybe effective against melanoma, breast and prostate cancers associated with fewer side-effects.
authors.affiliation: Bio-Tech R & D Institute, Kingston, Jamaica ; Educational and Scientific Corporation, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Henry Ic
authors.initials: HI
authors.lastname: Lowe
authors.affiliation: Educational and Scientific Corporation, University of Maryland School of Medicine, Baltimore, MD, USA ; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Ngeh J
authors.initials: NJ
authors.lastname: Toyang
authors.affiliation: Bio-Tech R & D Institute, Kingston, Jamaica.
authors.forename: Charah
authors.initials: C
authors.lastname: Watson
authors.affiliation: University of the West Indies, Mona Campus, Jamaica.
authors.forename: Simone
authors.initials: S
authors.lastname: Badal
authors.affiliation: Bio-Tech R & D Institute, Kingston, Jamaica ; University of the West Indies, Mona Campus, Jamaica.
authors.forename: Perceval
authors.initials: P
authors.lastname: Bahado-Singh
authors.affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Bryant
keywords: Jamaican Ball Moss; Tillandsia recurvata; breast cancer; dicinnamates; melanoma; prostate cancer