title: [Expressions of discoidin domain receptor 1 and matrix metalloproteinase 2 in salivary gland adenoid cystic carcinoma and clinical significance].
abstract: OBJECTIVE
  To investigate the expressions of discoidin domain receptor 1(DDR1) and matrix metalloproteinase 2(MMP2) in salivary gland adenoid cystic carcinoma (SACC) and discuss their significance and correlations with clinicopathological parameters.
  
  
  METHODS
  SP immunohistochemical method was used to detect the expressions of DDR1 and MMP2 in 54 samples of SACC and 30 normal salivary gland samples. SPSS 13.0 software package was used for statistical analysis.
  
  
  RESULTS
  The positive expression rate of DDR1 in SACC was 87.0%, which was significantly higher than that in normal salivary gland tissues (10.0%, P<0.01). The positive expression of DDR1 was related with neural invasion and lymph node metastasis (P<0.05). The positive expression rate of MMP2 was 68.5% in SACC, which was significantly higher than that in normal group(13.3%, P<0.01). The expression of DDR1 was positively correlated with MMP2 by Spearman rank analysis(r=0.332, P<0.05).
  
  
  CONCLUSIONS
  High expressions of DDR1 and MMP2 correlate with carcinogenesis and progress of SACC. Supported by Research Fund of Science and Technology Project of Liaoning Province (2012225100).
authors.affiliation: Department of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University. Shengyang 110004, Liaoning Province, China.E-mail:wangzm@sj-hospital.org.
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Ye
authors.forename: Yu-fei
authors.initials: YF
authors.lastname: Zhang
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhou
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Zhang
authors.forename: Wei-xian
authors.initials: WX
authors.lastname: Liu
mesh_terms: D003528:Carcinoma, Adenoid Cystic; D000070819:Discoidin Domain Receptor 1; D006801:Humans; D008207:Lymphatic Metastasis; D020778:Matrix Metalloproteinase 2; D020794:Receptor Protein-Tyrosine Kinases; D012468:Salivary Gland Neoplasms
chemical_list: C092030:DDR1 protein, human; D000070819:Discoidin Domain Receptor 1; D020794:Receptor Protein-Tyrosine Kinases; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2