title: Dl-3-n-butylphthalide is effective for demyelination: a case-combined study.
abstract: Demyelinating diseases is common in neurology department, but its treatment is still not clear. A 40-year-old male who was addicted in heroin was hospitalized and presented worsening altered mental status in hospital. Brain magnetic resonance imaging (MRI) revealed a symmetrical diffuse long T1 and long T2 time abnormalities in the white matter of cerebral hemispheres which indicated demyelination. High-dose intravenous methylprednisolone was not effective as expected. However, after treatment with intravenous Dl-3-n-butylphthalide for 7 days, the patient's symptoms and features of electroencephalogram (EEG) and MRI improved. Hence, ethidium bromide was used in a rat model to evaluate the positive effects of Dl-3-n-butylphthalide in demyelinating diseases. The results indicated that Dl-3-n-butylphthalide prevented white matter from demyelinating by regulating apoptosis through multiple approaches.
authors.affiliation: Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 6th Shuangyong Road, Nanning, Guangxi 530021, China. Electronic address: Nwuyuan90@163.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 6th Shuangyong Road, Nanning, Guangxi 530021, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 6th Shuangyong Road, Nanning, Guangxi 530021, China.
authors.forename: Xixia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 6th Shuangyong Road, Nanning, Guangxi 530021, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wei
mesh_terms: D000328:Adult; D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging*; D003711:Demyelinating Diseases / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011859:Radiography; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
chemical_list: D001572:Benzofurans; C027125:3-n-butylphthalide; D008775:Methylprednisolone
keywords: Apoptosis; Demyelination; Dl-3-n-butylphthalide; Heroin; Mitochondria