title: De novo synthesis of phenolic dihydroxanthene near-infrared emitting fluorophores.
abstract: We report a flexible de novo synthesis of phenolic dihydroxanthene fluorophores. The synthesis relies on a one-pot formation of an aldehyde intermediate which can be diversified in 60-70% overall yield, providing an efficient access to this family of near-infrared emitting fluorophores.
authors.affiliation: Organic Chemistry, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, #03-08, Singapore 138667, Singapore. jean_alexandre@ices.a-star.edu.sg.
authors.forename: Jean-Alexandre
authors.initials: JA
authors.lastname: Richard
mesh_terms: D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D010636:Phenols; D014966:Xanthenes