title: Phosphoinositide signaling in cancer: INPP4B Akt(s) out.
abstract: INPP4B acts as a tumor suppressor in various epithelial cancers by inhibiting PI3K/Akt signaling. Unexpectedly, tumor-promoting features of INPP4B in leukemia and breast cancer have been recently uncovered. In this spotlight, we discuss the seemingly paradoxical nature of INPP4B-mediated signaling in cancer.
authors.affiliation: Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
authors.forename: John F
authors.initials: JF
authors.lastname: Woolley
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
authors.forename: Irakli
authors.initials: I
authors.lastname: Dzneladze
authors.affiliation: Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address: leonardo.salmena@utoronto.ca.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Salmena
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D010716:Phosphatidylinositols; D051057:Proto-Oncogene Proteins c-akt; D010744:Phosphoric Monoester Hydrolases; C053153:phosphatidylinositol-3,4-bisphosphate 4-phosphatase
keywords: Akt; INPP4B; PI3K; oncogene; phosphoinositide; tumor suppressor