title: Validity of a Spanish Version of the Leicester Cough Questionnaire in Children With Cystic Fibrosis.
abstract: BACKGROUND
  Cystic fibrosis (CF) patients present chronic cough as one of the main symptoms, which has an important effect on quality of life and social relations. Our goal was to validate the Spanish version of the Leicester Cough Questionnaire (LCQ) in a group of children and teenagers with CF.
  
  
  METHODS
  After adapting to Spanish by standardized translation and retro-translation methodology, a sample of 58 stable CF patients from 7 to 18 years were recruited from three CF specialized centers in Spain. The questionnaire was administered twice; the second administration (LCQ2) was performed between 2-4 weeks later than the first one (LCQ1), in order to analyse the reliability and validity of the Spanish version. To correlate results with health related quality of life (HRQoL) we used the Cystic Fibrosis Questionnaire-Revised (CFQ-R).
  
  
  RESULTS
  Population was composed by 62% male, age 11.7 ± 3.1 years and body mass index (BMI) 19 ± 3 kg/m(2). Total scores from LCQ were: LCQ1 19 (17.75-21) vs LCQ2 19 (16-21) (P=.199). Cronbach's Alpha coefficient was 0.83 for the LCQtotal and for each specific domain was: 0.82 LCQphysical; 0.74 LCQpsychological and 0.62 LCQsocial. Intraclass correlation coefficient was: 0.69 LCQphysical; 0.59 LCQpsychological; 0.45 LCQsocial and 0.71 LCQtotal (good reliability). Relations with CFQ-R showed moderated and significant results: for the LCQtotal: respiratory symptom domain r = 0,51 (P<.001) and physical capacity domain r = 0,62 (P<.05).
  
  
  CONCLUSIONS
  The Spanish version of the Leicester Cough Questionnaire is reliable and valid for children and adolescents with CF and it has good relations with health related quality of life in this population.
authors.affiliation: Asociación Madrileña de Fibrosis Quística, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España.
authors.forename: Tamara
authors.initials: T
authors.lastname: Del Corral
authors.affiliation: Máster en Medicina Respiratoria, Universitat de Barcelona y Universitat Pompeu Fabra, Barcelona, España.
authors.forename: Janaína
authors.initials: J
authors.lastname: Percegona
authors.affiliation: Hospital de Sabadell, Corporació Sanitària Universitària Parc Taulí, Sabadell, Barcelona, España.
authors.forename: Núria
authors.initials: N
authors.lastname: López
authors.affiliation: Hospital de Sabadell, Corporació Sanitària Universitària Parc Taulí, Sabadell, Barcelona, España.
authors.forename: Andrea
authors.initials: A
authors.lastname: Valiente
authors.affiliation: Hospital Ramón y Cajal, Madrid, España.
authors.forename: María
authors.initials: M
authors.lastname: Garriga
authors.affiliation: Asociación Madrileña de Fibrosis Quística, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España.
authors.forename: Melisa
authors.initials: M
authors.lastname: Seborga
authors.affiliation: FCS Blanquerna, Grup de Recerca en Salut, Activitat Física i Esport (SAFE), Universitat Ramon Llull, Barcelona, España. Electronic address: jordivc@blanquerna.url.edu.
authors.forename: Jordi
authors.initials: J
authors.lastname: Vilaró
mesh_terms: D000293:Adolescent; D002648:Child; D003371:Cough / Q000175:diagnosis* / Q000209:etiology*; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D011788:Quality of Life; D011795:Surveys and Questionnaires
keywords: Cough; Cough questionnaire and health related quality of life; Cuestionario de tos y calidad de vida relacionada con la salud; Cystic fibrosis; Fibrosis quística; Tos