title: Proteomic signatures of antiplatelet drugs: new approaches to exploring drug effects.
abstract: Antiplatelet agents represent the mainstay of acute coronary syndrome (ACS) therapy to prevent ischemic events and to improve safety in patients undergoing percutaneous coronary intervention. However, despite the availability of several drugs and the use of dual antiplatelet therapy, the pharmacological response is highly variable with a subset of patients continuing to experience recurrent thrombotic events, revealing a wide variability in platelet response to antiplatelet drugs. Several factors may explain this, including genetic variation and environmental factors. Here we look at the application of proteomic analysis, an approach that provides an integrated readout of these diverse influences.
authors.affiliation: School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
authors.forename: S
authors.initials: S
authors.lastname: Marcone
authors.affiliation: School of Biomedical and Biomolecular Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
authors.forename: F
authors.initials: F
authors.lastname: Dervin
authors.affiliation: School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
authors.forename: D J
authors.initials: DJ
authors.lastname: Fitzgerald
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D004351:Drug Resistance; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011506:Proteins / Q000378:metabolism*; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010975:Platelet Aggregation Inhibitors; D011506:Proteins
keywords: antiplatelet drugs; biomarkers; cardiovascular diseases; platelets; proteomics