title: Accelerated Recovery of Endothelium Function after Stent Implantation with the Use of a Novel Systemic Nanoparticle Curcumin.
abstract: Curcumin was reported to exhibit a wide range of pharmacological effects including antioxidant, anti-inflammatory, and antiproliferative activities and significantly prevent smooth muscle cells migration. In the present study, a novel kind of curcumin loaded nanoparticles (Cur-NP) has been prepared and characterized with the aim of inhibiting inflammation formation and accelerating the healing process of the stented arteries. Cur-NP was administrated intravenously after stent implantation twice a week and detailed tissue responses were evaluated. The results demonstrated that intravenous administration of Cur-NP after stent implantation accelerated endothelial cells restoration and endothelium function recovery and may potentially be an effective therapeutic alternative to reduce adverse events for currently available drug eluting stents.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Ye
authors.affiliation: Department of Cardiology, First Affiliated People's Hospital of Suzhou University, Suzhou 215006, China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Gu
authors.affiliation: Department of Electrocardiogram, First Affiliated People's Hospital of Suzhou University, Suzhou 215006, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Feirong
authors.initials: F
authors.lastname: Gong
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001011:Aorta / Q000166:cytology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004355:Drug Stability; D054855:Drug-Eluting Stents; D004730:Endothelium, Vascular / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D051381:Rats; D013552:Swine
chemical_list: D000893:Anti-Inflammatory Agents; D003474:Curcumin