title: In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease.
abstract: The large 2014/2015 Ebola virus outbreak in West Africa points out the urgent need to develop new preventive and therapeutic approaches that are effective against Ebola viruses and  can be rapidly utilized. Recently, a simple theoretical criterion for the virtual screening of molecular libraries for candidate inhibitors of Ebola virus infection was proposed. Using this method the 'drug space' was screened and 267 approved and 382 experimental drugs as candidates for treatment of the Ebola virus disease (EVD) have been selected. Detailed analysis of these drugs revealed the non-steroidal anti-inflammatory drug ibuprofen as an inexpensive, widely accessible and minimally toxic candidate for prevention and treatment of EVD. Furthermore, the molecular mechanism underlying this possible protective effect of ibuprofen against EVD is suggested in this article.
authors.affiliation: Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
authors.forename: Veljko
authors.initials: V
authors.lastname: Veljkovic
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, Netherlands.
authors.forename: Marco
authors.initials: M
authors.lastname: Goeijenbier
authors.affiliation: Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Glisic
authors.affiliation: Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
authors.forename: Nevena
authors.initials: N
authors.lastname: Veljkovic
authors.affiliation: Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
authors.forename: Vladimir R
authors.initials: VR
authors.lastname: Perovic
authors.affiliation: Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Sencanski
authors.affiliation: Canadian Blood Services, Center for Innovation, 67 College Street, Toronto, M5G 2M1, Canada.
authors.forename: Donald R
authors.initials: DR
authors.lastname: Branch
authors.affiliation: Department of Pathology, Galveston National Laboratory, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, USA.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Paessler
keywords: NSAID; drug space; molecular libraries