title: Acute Urinary Retention Rates in the General Male Population and in Adult Men With Lower Urinary Tract Symptoms Participating in Pharmacotherapy Trials: A Literature Review.
abstract: Despite proven efficacy, antimuscarinics are not frequently used for treating lower urinary tract symptoms in adult men, due to the perception of an increased risk of acute urinary retention (AUR). Men treated with α-blockers, 5α-reductase inhibitors, or their combinations have lower AUR incidence rates than the general symptomatic population. In the selected study population in this review (men with post-void residuals ≤200 mL), the risk of AUR with antimuscarinics with and/or without α-blockers may be increased during short-term treatment, but if patients do not develop AUR in the first 3 months, their subsequent risk is lower than in the untreated, symptomatic population.
authors.affiliation: Department of Urology, Hannover Medical School, Hannover, Germany. Electronic address: oelke.matthias@mh-hannover.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Oelke
authors.affiliation: Department of Urology, Musgrove Park Hospital, Taunton, United Kingdom.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Speakman
authors.affiliation: Department of Urology, St. Louis Hospital, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Desgrandchamps
authors.affiliation: Department of Urology, University of Crete Medical School, Heraklion, Crete, Greece.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Mamoulakis
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D014943:Global Health; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D008297:Male; D009017:Morbidity / Q000639:trends; D012307:Risk Factors; D016055:Urinary Retention / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D064804:Urological Agents / Q000627:therapeutic use*
chemical_list: D064804:Urological Agents