title: Body Weight Reduction Results in Favorable Changes in Blood Pressure, Serum Lipids, and Blood Sugar in Middle-Aged Japanese Persons: A 5-Year Interval Observational Study of 26,824 Cases.
abstract: OBJECTIVE
  We investigated the relationships between body weight (BWt) and metabolic syndrome (MS) risk factors to elucidate the effect of BWt (?BWt) change and body mass index (BMI) on these factors in the Japanese population.
  
  
  METHODS
  Data were collected on MS-related parameters measured during two annual examinations of 16,640 men (mean age: 41.7±11.6 years) and 10,184 women (mean age: 45.0±12.2 years) without prior treatment of hypertension, diabetes mellitus, or dyslipidemia in 2006 and 2011 in Fukuoka, Japan. The subjects were divided into three groups according to BMI in 2006 (low, middle and high BMI) and into three groups according to change in BMI between 2006 and 2011 (decreased, stable, and increased BMI). Mean values for blood pressure (BP), systolic BP (SBP), diastolic BP (DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), hemoglobin A1c (HbA1c), and fasting blood glucose (FBG) for each group were determined by sex and subjected to statistical analysis for comparison.
  
  
  RESULTS
  High BMI (>26) was associated with higher SBP, LDL-C, FBG, and TG in both sexes. An increase≥1.1 BMI units in 5 years was associated with increased DBP, LDL-C, TG, HbA1c, and FBG and decreased HDL-C. In contrast, decreased BMI was associated with decreased BP and LDL-C and increased HDL-C in both sexes, and decreased TG in men and FBG in women.
  
  
  CONCLUSIONS
  Maintaining a desirable weight or losing weight may help prevent hypertension and MS, even in non-obese individuals.
authors.affiliation: College of Healthcare Management. mandai@medicalingual.com.
authors.forename: Nozomu
authors.initials: N
authors.lastname: Mandai
authors.forename: Kohei
authors.initials: K
authors.lastname: Akazawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ide
authors.forename: Koichi
authors.initials: K
authors.lastname: Ide
authors.forename: Ushio
authors.initials: U
authors.lastname: Dazai
authors.forename: Akiko
authors.initials: A
authors.lastname: Chishaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Chishaki
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D007564:Japan; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000517:prevention & control; D008875:Middle Aged; D012189:Retrospective Studies; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D008055:Lipids