title: Clinical insights by the presence of bipolar disorder in pseudohypoparathyroidism type 1A.
abstract: Pseudohypoparathyroidism type 1A and its association with bipolar disorder (BD) have never been reported so far. We report a new case with both clinical entities and discuss the potential pathophysiological mechanisms of this association (protein kinase A hypoactivation, parathyroid hormone, hypocalcemia, protein kinase C activation, vitamin D deficiency). In this patient, the correction of the underlying calcium and vitamin D deficiencies leads to a better BD outcome and lower dosage of psychopharmacological agents. The conclusions might be generalized for a better understanding and management of these conditions.
authors.affiliation: Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, Italy. Electronic address: i.kadilli@outlook.com.
authors.forename: Irket
authors.initials: I
authors.lastname: Kadilli
authors.affiliation: Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Colicchio
authors.affiliation: Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Guglielmo
authors.affiliation: Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Catello
authors.initials: C
authors.lastname: Vollono
authors.affiliation: Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Della Marca
authors.affiliation: Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Janiri
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications*; D015897:Comorbidity; D005260:Female; D006801:Humans; D011547:Pseudohypoparathyroidism / Q000150:complications* / Q000503:physiopathology; D014808:Vitamin D Deficiency / Q000150:complications
keywords: Bipolar disorder; GNAS1 mutation; Pseudohypoparathyroidism type 1A; Vitamin D deficiency