title: Trajectories of Obesity and Overweight Rates Among Survivors of Childhood Acute Lymphoblastic Leukemia.
abstract: OBJECTIVE
  To describe the trajectories of obesity/overweight rates by age group among survivors of childhood acute lymphoblastic leukemia (ALL) from diagnosis through several years post-therapy.
  
  
  METHODS
  Longitudinal, descriptive.
  
  
  METHODS
  Hematology/oncology clinic in the southwestern United States.
  
  
  METHODS
  62 child and adolescent ALL survivors receiving treatment and follow-up care from 1999-2013.
  
  
  METHODS
  Retrospective chart review of height, weight, and body mass index.
  
  
  METHODS
  Annual obesity/overweight rates and developmental age groups.
  
  
  RESULTS
  Different trajectories of obesity/overweight rates existed among age groups. Forty-seven percent of adolescents met the Centers for Disease Control and Prevention criteria for obesity/overweight status at some point following diagnosis, compared to 68% of school-age and 73% of preschool children. Preschool children demonstrated the most rapid rate increase following diagnosis, with a particularly susceptible period in the years immediately following therapy. Obesity/overweight persistence was most characteristic of school-age children.
  
  
  CONCLUSIONS
  Important variations in rate and pattern of weight status trajectories exist by age group, demonstrating that children diagnosed with ALL during the preschool and school-age developmental years have the greatest vulnerability of developing obesity/overweight status.
  
  
  CONCLUSIONS
  Obesity/overweight prevention efforts are greatly needed in children with ALL, and efforts should occur before ALL treatment completion in preschool and school-age children.
authors.affiliation: Duke University in Durham, NC.
authors.forename: Megan R
authors.initials: MR
authors.lastname: Winkler
authors.affiliation: Duke University in Durham, NC.
authors.forename: Marilyn J
authors.initials: MJ
authors.lastname: Hockenberry
authors.affiliation: Baylor College of Medicine in Houston, TX.
authors.forename: Kathy S
authors.initials: KS
authors.lastname: McCarthy
authors.affiliation: School of Nursing at Duke University.
authors.forename: Susan G
authors.initials: SG
authors.lastname: Silva
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000209:etiology*; D063766:Pediatric Obesity / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy*; D012189:Retrospective Studies; D015206:Southwestern United States; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents
keywords: adolescent; child; leukemia; pediatric obesity; preschool