title: [Vascular endothelial Barrier Function].
abstract: Endothelium is an important regulator of selective permeability of the vascular wall for different molecules and cells. This review summarizes current data on endothelial barrier function. Endothelial glycocalyx structure, its function and role in the molecular transport and leukocytes migration across the endothelial barrier are discussed. The mechanisms of transcellular transport of macromolecules and cell migration through endothelial cells are reviewed. Special section of this article addresses the structure and function of tight and adherens endothelial junction, as well as their importance for the regulation of paracellular transport across the endothelial barrier. Particular attention is paid to the signaling mechanism of endothelial barrier function regulation and the factors that influence on the vascular permeability.
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanov
authors.forename: D M
authors.initials: DM
authors.lastname: Puchinyan
authors.forename: I A
authors.initials: IA
authors.lastname: Norkin
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000502:physiology; D002465:Cell Movement; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D019276:Glycocalyx / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000502:physiology; D046911:Macromolecular Substances / Q000378:metabolism*; D015398:Signal Transduction; D019108:Tight Junctions / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D015815:Cell Adhesion Molecules; D046911:Macromolecular Substances