title: Yeast with bacteriocin from ruminal bacteria enhances glucose utilization, reduces ectopic fat accumulation, and alters cecal microbiota in dietary-induced obese mice.
abstract: BACKGROUND
  This study investigated the effect of yeast with bacteriocin (YB) on the homeostasis of lipid and glucose in diet-induced obese (DIO) mice. Seven-week-old C57BL/6 male mice were fed with a Western diet for 24 weeks to induce obesity. These DIO mice were randomly assigned to 2 groups: obese control (WS) and WYB [0.125 μg YB per g body weight (BW)]. YB was administered daily to the WYB mice in the last 4 weeks, while an equal volume of normal saline was administered to the WS mice.
  
  
  RESULTS
  YB caused a significant reduction in BW, and in plasma levels of total cholesterol and glucose. Less hepatic lipid accumulation and smaller adipocytes were observed in WYB mice. WYB mice had higher lipid catabolism in liver and adipose tissue. Compared with WS mice, WYB mice had higher glycolysis in the liver and muscles. YB suppressed hepatic GLUT5 expression, altered the composition of cecal microbiota, and also caused more efficient carbohydrate utilization for energy expenditure.
  
  
  CONCLUSIONS
  YB resulted in body weight loss, promoted lipid catabolism and carbohydrate utilization; it also modulated cecal microbiota, and therefore partially improved the health of obese mice.
authors.affiliation: Department of Animal Science and Technology, National Taiwan University, No. 50, Lane 155, Sec 3, Keelung Rd, Taipei, Taiwan. ronichen@ntu.edu.tw.
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Tsai
authors.forename: Han-Tsung
authors.initials: HT
authors.lastname: Wang
authors.forename: Jih-Tay
authors.initials: JT
authors.lastname: Hsu
authors.forename: Yi-Hung
authors.initials: YH
authors.lastname: Li
authors.forename: Ching-Yi
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D001430:Bacteriocins / Q000008:administration & dosage* / Q000235:genetics / Q000378:metabolism; D002432:Cecum / Q000382:microbiology*; D005223:Fats / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D001430:Bacteriocins; D005223:Fats; C581354:albusin B, Ruminococcus albus; D005947:Glucose