title: Recent Advances in Biocatalytic Promiscuity: Hydrolase-Catalyzed Reactions for Nonconventional Transformations.
abstract: Enzymes have emerged in recent decades as ideal catalysts for synthetic transformations under mild reaction conditions. Their capacity to accelerate a myriad of biotransformations with high levels of selectivity and broad substrate specificity including excellent atom economy has led to a current full recognition. The six classes of enzymes (oxidoreductases, transferases, hydrolases, lyases, isomerases and ligases) possess outstanding abilities to perform specific modifications in target molecules. Nevertheless, in the last fifteen years, novel examples have appeared related to nonconventional processes catalyzed by various classes of biocatalysts. Amongst these, hydrolases have received special attention since they display remarkable activities in initially unexpected reactions such as carbon-carbon and carbon-heteroatom bond-formation reactions, oxidative processes and novel hydrolytic transformations. In this review, the main findings in this area will be disclosed, highlighting the catalytic properties of hydrolases not only to catalyze single processes but also multicomponent and tandem nonconventional reactions.
authors.affiliation: Organic and Inorganic Chemistry Department, Biotechnology Institute of Asturias, Universidad de Oviedo, Avenida Julián Clavería s/n, Oviedo, 33006, Spain.
authors.forename: María
authors.initials: M
authors.lastname: López-Iglesias
authors.affiliation: Organic and Inorganic Chemistry Department, Biotechnology Institute of Asturias, Universidad de Oviedo, Avenida Julián Clavería s/n, Oviedo, 33006, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor-Fernández
mesh_terms: D000818:Animals; D055162:Biocatalysis; D006801:Humans; D006867:Hydrolases / Q000378:metabolism*; D008049:Lipase / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D006867:Hydrolases; D008049:Lipase
keywords: biocatalytic promiscuity; enzymes; hydrolases; lipases; organic synthesis