title: Linking trait-based phenotypes to prefrontal cortex activation during inhibitory control.
abstract: Inhibitory control is subserved in part by discrete regions of the prefrontal cortex whose functionality may be altered according to specific trait-based phenotypes. Using a unified model of normal range personality traits, we examined activation within lateral and medial aspects of the prefrontal cortex during a manual go/no-go task. Evoked hemodynamic oxygenation within the prefrontal cortex was measured in 106 adults using a 16-channel continuous-wave functional near-infrared spectroscopy system. Within lateral regions of the prefrontal cortex, greater activation was associated with higher trait levels of extraversion, agreeableness and conscientiousness, and lower neuroticism. Higher agreeableness was also related to more activation in the medial prefrontal cortex during inhibitory control. These results suggest that personality traits reflecting greater emotional stability, extraversion, agreeableness and conscientiousness may be associated with more efficient recruitment of control processes subserved by lateral regions of the prefrontal cortex. These findings highlight key links between trait-based phenotypes and neural activation patterns in the prefrontal cortex underlying inhibitory control.
authors.affiliation: Department of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada and.
authors.forename: Achala H
authors.initials: AH
authors.lastname: Rodrigo
authors.affiliation: Department of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada and.
authors.forename: Stefano I
authors.initials: SI
authors.lastname: Di Domenico
authors.affiliation: Department of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada and.
authors.forename: Bryanna
authors.initials: B
authors.lastname: Graves
authors.affiliation: Department of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada and.
authors.forename: Jaeger
authors.initials: J
authors.lastname: Lam
authors.affiliation: School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
authors.forename: Hasan
authors.initials: H
authors.lastname: Ayaz
authors.affiliation: Department of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada and.
authors.forename: R Michael
authors.initials: RM
authors.lastname: Bagby
authors.affiliation: Department of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada and anthony.ruocco@gmail.com.
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Ruocco
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007206:Individuality; D007266:Inhibition, Psychological; D008297:Male; D010100:Oxygen / Q000097:blood*; D010641:Phenotype; D017397:Prefrontal Cortex / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared; D013694:Temperament / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: five-factor model; inhibitory control; personality traits; prefrontal cortex