title: Recurrent pulmonary synovial sarcoma effectively treated with amrubicin: A case report.
abstract: Pulmonary synovial sarcoma is a rare but aggressive disease. The present study describes the case of a 68-year-old female with pulmonary synovial sarcoma. The patient was mistakenly treated for small cell lung cancer due to false-positive staining for synaptophysin and cluster of differentiation 56. Despite severe myelotoxicity, platinum-containing chemotherapies (cisplatin plus irinotecan and carboplatin plus etoposide) were not effective. As a third-line therapy, the patient received amrubicin (AMR) monotherapy. A partial response was achieved, and the patient was able to undertake ordinary daily life at home for 13 months from the initiation of AMR chemotherapy. Due to the atypical clinical condition and unusual response to chemotherapy in this patient, the pathological examination was repeated. The SS18 split-signal was detected in fluorescencein situhybridization analysis. From these results, the tumor was diagnosed as a monophasic synovial sarcoma. To the best of our knowledge, this is the first case of a patient with pulmonary synovial sarcoma who underwent successful treatment with AMR. The present case could demonstrate a specific chemosensitivity of such a rare tumor.
authors.affiliation: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 210-0015, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
authors.affiliation: Division of Pathology, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 210-0015, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Takayashiki
authors.affiliation: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shiozawa
authors.affiliation: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Miyazaki
authors.affiliation: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 210-0015, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Ohara
authors.affiliation: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 210-0015, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Kagohashi
authors.affiliation: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 210-0015, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kurishima
authors.affiliation: Department of Pathology, Sapporo Medical University, Sapporo, Hokkaido 060-8556, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Sugita
authors.affiliation: Department of Pathology, Sapporo Medical University, Sapporo, Hokkaido 060-8556, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Aoyama
authors.affiliation: Department of Pathology, Sapporo Medical University, Sapporo, Hokkaido 060-8556, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
authors.affiliation: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
keywords: amrubicin; chemotherapy; pulmonary synovial sarcoma