title: Autologous fat augmentation of the vocal fold with basic fibroblast growth factor: Computed tomographic assessment of fat tissue survival after augmentation.
abstract: CONCLUSIONS
  The volume of fat tissue loss after vocal fold augmentation can be decreased when augmentation is performed with addition of basic fibroblast growth factor (b-FGF).
  
  
  OBJECTIVE
  The effectiveness of augmentation is easily decreased due to absorption. Canine experiments have confirmed that the decreased effectiveness caused by absorption after augmentation can be reduced by administering low-concentration b-FGF. Clinical application was trialed after acquiring approval from the institutional clinical review committee.
  
  
  METHODS
  Autologous fat tissue with b-FGF was injected into the vocal folds in cases of unilateral vocal cord paralysis. This study compared fat tissue survival after injection by assessing images from computed tomography (CT).
  
  
  RESULTS
  Assessments using CT revealed that the decrease in volume of injected fat tissue was smaller in cases treated using b-FGF than in cases using the conventional method. No severe complications were encountered using this method.
authors.affiliation: a 1 Department of Otorhinolaryngology, Tokai University School of Medicine, Tokai University Tokyo Hospital , Tokyo, Japan.
authors.forename: Etsuyo
authors.initials: E
authors.lastname: Tamura
authors.affiliation: b 2 Institute for Frontier Medical Sciences, Kyoto University , Kyoto, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
authors.affiliation: c 3 Health Screening Center, Tokai University Tokyo Hospital , Tokyo, Japan.
authors.forename: Chizumi
authors.initials: C
authors.lastname: Yamada
authors.affiliation: d 4 Department of Otorhinolaryngology, Tokai University School of Medicine, Tokai University Hachioji Hospital , Tokyo, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Okada
authors.affiliation: e 5 Department of Otorhinolaryngology, Tokai University School of Medicine , Kanagawa, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iida
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000368:Aged; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014826:Vocal Cord Paralysis / Q000000981:diagnostic imaging / Q000628:therapy*; D014827:Vocal Cords; D014833:Voice Quality
chemical_list: D016222:Fibroblast Growth Factor 2
keywords: Regenerative medicine; autologous fat tissue; unilateral vocal cord paralysis