title: Intracranial meningiomas and seizures: a review of the literature.
abstract: BACKGROUND
  Seizures are a common manifestation of brain tumors, but literature on the incidence of seizures before and after surgery for meningiomas is limited, and principles for use of antiepileptic drugs (AEDs) are controversial.
  
  
  METHODS
  This review is based on a MEDLINE search for articles from 1994 to 2014 describing intracranial meningioma and seizures or epilepsy, and AEDs treatment during and after surgery.
  
  
  RESULTS
  Up to 40 % of patients with symptomatic meningiomas present with seizures before operation. Tumor removal usually results in seizure control, but around 20 % of patients continue to have or develop new-onset seizures after surgery. Risk factors for seizures after surgery include preoperative seizures, tumor location, and extent of tumor removal. There are no solid data to support routine pre- or postoperative AED prophylaxis in seizure-free patients, and the decision to treat and the selection of AEDs should follow the general principles of treatment of focal epilepsies.
  
  
  CONCLUSIONS
  Seizures are a common manifestation of meningiomas, but about 80 % patients with preoperative seizures can be seizure free after tumor removal. Prospective controlled AED trials specifically on meningioma patients are much needed.
authors.affiliation: Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China, marcoxue2003@hotmail.com.
authors.forename: Hai
authors.initials: H
authors.lastname: Xue
authors.forename: Olafur
authors.initials: O
authors.lastname: Sveinsson
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Tomson
authors.forename: Tiit
authors.initials: T
authors.lastname: Mathiesen
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D006801:Humans; D008577:Meningeal Neoplasms / Q000601:surgery*; D008579:Meningioma / Q000601:surgery*; D019635:Neurosurgical Procedures / Q000009:adverse effects; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000927:Anticonvulsants