title: Wireless programmable electrochemical drug delivery micropump with fully integrated electrochemical dosing sensors.
abstract: We present a fully integrated implantable electrolysis-based micropump with incorporated EI dosing sensors. Wireless powering and data telemetry (through amplitude and frequency modulation) were utilized to achieve variable flow control and a bi-directional data link with the sensors. Wireless infusion rate control (0.14-1.04 μL/min) and dose sensing (bolus resolution of 0.55-2 μL) were each calibrated separately with the final circuit architecture and then simultaneous wireless flow control and dose sensing were demonstrated. Recombination detection using the dosing system, as well as, effects of coil separation distance and misalignment in wireless power and data transfer were studied. A custom-made normally closed spring-loaded ball check valve was designed and incorporated at the reservoir outlet to prevent backflow of fluids as a result of the reverse pressure gradient caused by recombination of electrolysis gases. Successful delivery, infusion rate control, and dose sensing were achieved in simulated brain tissue.
authors.affiliation: Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB-140, Los Angeles, CA, 90089-1111, USA.
authors.forename: Roya
authors.initials: R
authors.lastname: Sheybani
authors.forename: Angelica
authors.initials: A
authors.lastname: Cobo
authors.forename: Ellis
authors.initials: E
authors.lastname: Meng
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation; D002138:Calibration; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004572:Electrolysis / Q000295:instrumentation*; D004867:Equipment Design; D008297:Male; D051379:Mice; D011312:Pressure; D019736:Prostheses and Implants; D051381:Rats; D013686:Telemetry / Q000295:instrumentation; D059015:Wireless Technology