title: Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain.
abstract: BACKGROUND
  Chemotherapy induced neuropathy pain remains as a major dose limiting side effect of many commonly used chemotherapeutic drugs. Presently newer antiepileptic agents have been developed with improved safety and tolerability profiles in alleviating neuropathic pain.
  
  
  OBJECTIVE
  To evaluate the effect of Gabapentin and Pregabalin in Paclitaxel (Taxol) induced neuropathic pain and to compare the effect of these drugs in animal models.
  
  
  METHODS
  Rats were randomly divided into four groups of six animals each. Group 1- vehicle, Group 2 - Paclitaxel (2mg/kg), Group 3 - Gabapentin (60mg/kg) with Paclitaxel, Group 4 - Pregabalin (30mg/kg) with Paclitaxel. Pain was induced by intraperitoneal injection of Paclitaxel on four alternate days. After taking the baseline values, the drugs treated groups (group 3 and 4) were administered with respective drugs once a day orally for eight consecutive days along with paclitaxel. All the animals were tested for thermal hyperalgesia and cold allodynia on day 0, 7, 14, 21 and 28 with Radiant heat method and Tail immersion test, Acetone drop method respectively.
  
  
  RESULTS
  In Radiant heat method, gabapentin and pregabalin treated animals found to have significant increase in the tail latency period compared to control and paclitaxel treated groups in all periods of observation. Acetone drop test and tail immersion test also showed significant response similar to Radiant heat method. Pregabalin showed highly significant effect when compared to gabapentin group.
  
  
  CONCLUSIONS
  Both gabapentin and pregabalin produced significant anti-hyperalgesic and anti-allodynic effects in experimental animal models. Pregabalin treated group showed highly significant effect compared to gabapentin treated animals.
authors.affiliation: Professor, Department of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital , Puducherry, India .
authors.forename: A
authors.initials: A
authors.lastname: Mangaiarkkarasi
authors.affiliation: Postgraduate, Department of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital , Puducherry, India .
authors.forename: S
authors.initials: S
authors.lastname: Rameshkannan
authors.affiliation: Professor and Head, Department of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital , Puducherry, India .
authors.forename: R Meher
authors.initials: RM
authors.lastname: Ali
keywords: Acetone drop method; Cold allodynia; Paclitaxel; Radiant heat; Tail immersion; Thermal hyperalgesia