title: Low EphA7 Expression Correlated with Lymph Node Metastasis and Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma.
abstract: As a member of the Eph family of receptor tyrosine kinases, EphA7 plays an important role in cancer. However, the expression and significance of Eph receptors in esophageal squamous cell carcinoma (ESCC) remain unclear. Here, we detected the expression of EphA7 by immunohistochemistry in a sample of 352 patients with ESCC, and aimed to investigate the expression status of EphA7 in ESCC and its impact on prognosis. The results showed that low EphA7 expression significantly correlated with lymph node metastases (N0: 29%; N1: 64%. p<0.001), poor degree of tumor differentiation (G1: 31%; G2: 49%; G3: 58%. p=0.009) and pTNM staging (I+II: 33%; III+IV: 58%. p<0.001). Furthermore, in a combined analysis, patients with low EphA7-expressing tumors showed a shorter overall survival than those with high expression, resulting in a five-year overall survival rate of 47.4% vs. 52.6%, respectively (p=0.016). Consequently, patients with a low EphA7 expression have poorer prognosis in ESCC compared with those manifesting high expression.
authors.affiliation: Department of Pathology, Medical College of Chifeng University ; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Bai
authors.affiliation: Department of Pathology, Medical College of Chifeng University ; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College.
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Research Centre of Molecular Medicine, Medical College of Chifeng University ; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College.
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Bai
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College ; Institute of Oncologic Pathology, Medical College of Shantou University.
authors.forename: Xiu-E
authors.initials: XE
authors.lastname: Xu
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College ; Department of Biochemistry and Molecular Biology, Medical College of Shantou University , Shantou 515041, China.
authors.forename: Jian-Yi
authors.initials: JY
authors.lastname: Wu
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College ; Institute of Oncologic Pathology, Medical College of Shantou University.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College ; Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wu
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College ; Oncology Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University , Shantou 515041, China.
authors.forename: Shao-Hong
authors.initials: SH
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College ; Institute of Oncologic Pathology, Medical College of Shantou University.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College ; Oncology Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University , Shantou 515041, China.
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Shen
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College ; Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Yao
authors.affiliation: Department of Pathology, The Second Hospital of Chifeng City , Chifeng 024000, China.
authors.forename: Lian-Zhu
authors.initials: LZ
authors.lastname: Gao
authors.affiliation: Department of Histology and Embryology, Medical College of Chifeng University , Chifeng 024000, China.
authors.forename: Bao
authors.initials: B
authors.lastname: Wu
authors.affiliation: Department of Pediatrics, Affiliated Hospital of Chifeng University , Chifeng 024000, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Gu
authors.affiliation: Department of Pathology, Medical College of Chifeng University.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Department of Pathology, Medical College of Chifeng University.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College.
authors.forename: En-Min
authors.initials: EM
authors.lastname: Li
authors.affiliation: The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Xu
keywords: EphA7; esophageal squamous cell carcinoma; immunohistochemistry; lymph mode metastasis; prognosis