title: Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease.
abstract: We report a 46-year-old white woman with adult-onset Still's disease (AOSD) treated with anakinra, a IL-1B receptor antagonist. Within weeks, her liver enzymes deteriorated; subsequent cessation and rechallenge confirmed anakinra-related drug-induced liver injury (DILI). Although AOSD has been associated with liver involvement, little is known about the hepatotoxicity of anakinra. Heightened awareness by gastroenterologists and hepatologists is warranted.
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Toronto Western Hospital, University of of Toronto, Toronto, Ontario, Canada.
authors.forename: Osman
authors.initials: O
authors.lastname: Ahmed
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Toronto Western Hospital, University of of Toronto, Toronto, Ontario, Canada.
authors.forename: Mayur
authors.initials: M
authors.lastname: Brahmania
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Majid
authors.initials: M
authors.lastname: Alsahafi
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Saad
authors.initials: S
authors.lastname: Alkhowaiter
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Sig
authors.initials: S
authors.lastname: Erb