title: Insight into the Spectrum of Coronary Atherosclerosis in Asymptomatic Urban Han Chinese Population by Coronary Computed Tomography Angiography.
abstract: OBJECTIVE
  Highlighted the spectrum of coronary atherosclerosis in asymptomatic population by Computed Tomography Angiography (CTA) and developed a surrogation of expensive CTA to early detect coronary atherosclerosis.
  
  
  METHODS
  Three hundred and seven self-referred urban Han Chinese asymptomatic individuals underwent coronary CTA were consecutively enrolled. Total plaque score (TPS), Segment stenosis score (SSS) and Coronary Artery Disease severity (CADS) were used to measure and illustrate the spectrum of atherosclerosis burden by mapping their incidence and proportion onto coronary artery tree. Logistic regression model was further used to explore the association between lipid biomarkers and TPS (SSS) for developing a surrogation of CTA to early detect coronary atherosclerosis.
  
  
  RESULTS
  We found that the incidence of TPS, SSS and CADS were up to 71.34%, 68.08%, and 71.34%; and high-risk individuals reached up to 11.07%, 15.31% and 16.29% respectively. All TPS, SSS and CADS were much higher in male than female, and have trend of increasing with age. The most lesion segment emerged on proximal LAD, followed by proximal RCA, mid LAD, proximal LCX, and mid RCA with mixed plaque as dominant. HDL-C was a predictor to both TPS [OR: 0.12 (0.02-0.82)] and SSS [OR: 0.15 (0.03-0.76)], and could identify the serious atherosclerosis subjects of TPS or SSS score >5 (AUC 0.73 and 0.70).
  
  
  CONCLUSIONS
  The atherosclerosis plaque burden was about one in ten as high-risk individuals in this specific urban Han Chinese population. As potential surrogation of CTA, HDL-C was recognized as a significant predictor to atherosclerosis burden and revealed a good performance for identifying high-risk individuals.
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
authors.forename: Jiangbing
authors.initials: J
authors.lastname: Li
authors.affiliation: Division of Biostatistics, School of Public Health, Shandong University, Shandong, China.
authors.forename: Ruihong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Division of Biostatistics, School of Public Health, Shandong University, Shandong, China.
authors.forename: Xiaokang
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Neurosurgery, Qilu Hospital, Shandong University, Shandong, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xue
authors.affiliation: Health Management Center of Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Health Management Center of Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Wang
authors.affiliation: Health Management Center of Shengli Qilfield Central Hospital, Shandong, China.
authors.forename: Qicai
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Division of Biostatistics, School of Public Health, Shandong University, Shandong, China.
authors.forename: Fuzhong
authors.initials: F
authors.lastname: Xue
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
authors.forename: Lianqun
authors.initials: L
authors.lastname: Cui
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D015994:Incidence; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D012372:ROC Curve; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014504:Urban Health / Q000706:statistics & numerical data; D014505:Urban Population / Q000706:statistics & numerical data
chemical_list: D008076:Cholesterol, HDL; D008055:Lipids