title: A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching.
abstract: To evaluate the efficacy of experimental proposals of desensitizing agents during tooth bleaching.
  
  
  
  140 participants without tooth sensitivity (TS) received 16% carbamide peroxide (14 days-04 h each) (T1) or 35% hydrogen peroxide (single session-45 min) (T2). Participants used concomitantly (10 per group): desensitizing dentifrices (D1-experimental bioactive glass-ceramic; D2-commercial potassium nitrate; D3-commercial calcium and sodium phosphosilicate) in-home, daily and, desensitizing pastes (D4-experimental bioactive glass-ceramic; D5-experimental Bioglass type 45S5; D6-commercial calcium phosphate), in-office, immediately after the treatment and more 4 times. Participants in the control group did not use any desensitizing agent. We assessed TS with Visual Analogue Scale. Assessment point 1 was immediately after the first participant's exposure to the treatments; and points 2, 3, 4, and 5 were every 72 h along the period of the study. Two-way ANOVA (considering time and desensitizing as factors) and post-hoc Tukey test (α=0.05) analyzed the data.
  
  
  
  In the control group treated with 35% hydrogen peroxide, TS increased significantly on assessment points 1 and 2. The participants who used a 5% potassium nitrate dentifrice and in-office experimental pastes did not experience TS because of the 35% in-office bleaching treatment.
  
  
  
  TS caused by 35% hydrogen peroxide in-office tooth bleaching was controlled by experimental products prepared as pastes D4-experimental bioactive glass-ceramic and D5-experimental Bioglass type 45S5, but not by D1-experimental dentifrice containing bioactive glass-ceramic.
  
  
  
  There is no a gold standard protocol for TS caused by tooth bleaching. The study of novel desensitizing agents that can obliterate the dentinal tubules in a faster-acting and long-lasting way may help meet this clinical need.
authors.affiliation: Department of Dental Materials and Prosthodontics, School of Dentistry of Ribeirão Preto, University of São Paulo, 14040-904, Brazil.
authors.forename: Karen
authors.initials: K
authors.lastname: Pintado-Palomino
authors.affiliation: Vitreous Materials Laboratory, Department of Materials Engineering, Federal University of São Carlos, 13565-905, Brazil.
authors.forename: Oscar
authors.initials: O
authors.lastname: Peitl Filho
authors.affiliation: Vitreous Materials Laboratory, Department of Materials Engineering, Federal University of São Carlos, 13565-905, Brazil.
authors.forename: Edgar Dutra
authors.initials: ED
authors.lastname: Zanotto
authors.affiliation: Department of Dental Materials and Prosthodontics, School of Dentistry of Ribeirão Preto, University of São Paulo, 14040-904, Brazil. Electronic address: catirapelli@forp.usp.br.
authors.forename: Camila
authors.initials: C
authors.lastname: Tirapelli
mesh_terms: D000293:Adolescent; D000328:Adult; D002130:Calcium Phosphates / Q000008:administration & dosage; D000077463:Carbamide Peroxide; D002516:Ceramics / Q000627:therapeutic use; D003802:Dentifrices / Q000008:administration & dosage; D057133:Dentin Desensitizing Agents / Q000008:administration & dosage*; D003807:Dentin Sensitivity / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage; D008297:Male; D009566:Nitrates / Q000008:administration & dosage; D004366:Nonprescription Drugs / Q000008:administration & dosage; D009824:Ointments / Q000008:administration & dosage; D010147:Pain Measurement; D010545:Peroxides / Q000008:administration & dosage; D017680:Potassium Compounds / Q000008:administration & dosage; D012648:Self Care / Q000379:methods; D014073:Tooth Bleaching / Q000009:adverse effects* / Q000379:methods*; D058205:Tooth Bleaching Agents / Q000008:administration & dosage*; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives; D055815:Young Adult
chemical_list: C022107:Bioglass; D002130:Calcium Phosphates; D003802:Dentifrices; D057133:Dentin Desensitizing Agents; D009566:Nitrates; D004366:Nonprescription Drugs; D009824:Ointments; D010545:Peroxides; D017680:Potassium Compounds; D058205:Tooth Bleaching Agents; D000077463:Carbamide Peroxide; D014508:Urea; C020243:calcium phosphate; D006861:Hydrogen Peroxide; C023844:potassium nitrate
keywords: Esthetic dentistry; Tooth bleaching; Tooth sensitivity