title: Improvement of Heart Redox States Contributes to the Beneficial Effects of Selenium Against Penconazole-Induced Cardiotoxicity in Adult Rats.
abstract: The present study was performed to evaluate the protective effect of selenium (Se) against penconazole (PEN)-induced oxidative stress in the cardiac tissue of adult rats. Male Wistar rats were divided into four groups of six each. The first group represented the controls. For the second group (PEN), no treatment was performed during the first 6 days, and then, the rats received intraperitoneally 67 mg/kg body weight (bw) of PEN every 2 days from day 7 until day 15, the sacrifice day. For the third group (Se + PEN), Se was administered daily through the diet at a dose of 0.5 mg/kg of diet for 15 days. Rats of this group received also every 2 days PEN (67 mg/kg bw) from day 7 until day 15. The fourth group (Se) received daily, through the diet, Se (0.5 mg/Kg of diet) during 15 days. Our results showed that Se reduced significantly the elevated cardiac levels of malondialdehyde and protein carbonyl following PEN treatment, and attenuated DNA fragmentation induced by this fungicide. In addition, Se modulated the alterations of antioxidant status: enzymatic (superoxide dismutase, glutathione peroxidase, and catalase) and nonenzymatic (glutathione and vitamin C) antioxidants in the heart of PEN-treated rats. This trace element was also able to alleviate perturbations of lipid profile. The protective effect of selenium was further evident through the histopathological changes produced by PEN in the heart tissue. Taken together, our results indicated that Se might be beneficial against PEN-induced cardiac oxidative damage in rats.
authors.affiliation: Enzymes and Bioconversion Unit, National Engineering School of Sfax, University of Sfax, 3038, Sfax, Tunisia.|Animal Physiology Laboratory, Department of Life Sciences, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia.
authors.forename: Mariem
authors.initials: M
authors.lastname: Chaâbane
authors.affiliation: Physiology and aquatic environment laboratory, UR13 ES 35, Tunis Faculty of Sciences, 2092, University of Tunis El Manar, Farhat Hached University Campus El Manar, Tunis. B.P.n 94, 1068, Rommana, Tunisia.
authors.forename: Meriem
authors.initials: M
authors.lastname: Tir
authors.affiliation: Biochemistry Laboratory, University of Sfax, CHU Hedi Chaker, 3029, Sfax, Tunisia.
authors.forename: Safa
authors.initials: S
authors.lastname: Hamdi
authors.affiliation: Histopathology Laboratory, University of Sfax, CHU Habib Bourguiba, 3029, Sfax, Tunisia.
authors.forename: Ons
authors.initials: O
authors.lastname: Boudawara
authors.affiliation: Biochemistry Laboratory, University of Sfax, CHU Hedi Chaker, 3029, Sfax, Tunisia.
authors.forename: Kamel
authors.initials: K
authors.lastname: Jamoussi
authors.affiliation: Histopathology Laboratory, University of Sfax, CHU Habib Bourguiba, 3029, Sfax, Tunisia.
authors.forename: Tahia
authors.initials: T
authors.lastname: Boudawara
authors.affiliation: Enzymes and Bioconversion Unit, National Engineering School of Sfax, University of Sfax, 3038, Sfax, Tunisia.
authors.forename: Raoudha Ellouze
authors.initials: RE
authors.lastname: Ghorbel
authors.affiliation: Animal Physiology Laboratory, Department of Life Sciences, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia. najiba.zeghal@tunet.tn.
authors.forename: Najiba
authors.initials: N
authors.lastname: Zeghal
authors.affiliation: Animal Physiology Laboratory, Department of Life Sciences, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000, Sfax, Tunisia.
authors.forename: Nejla
authors.initials: N
authors.lastname: Soudani
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D066126:Cardiotoxicity / Q000517:prevention & control; D005659:Fungicides, Industrial / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D014230:Triazoles / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D005659:Fungicides, Industrial; D014230:Triazoles; C087058:penconazole; D012643:Selenium
keywords: Cardiotoxicity; Penconazole; Rats; Selenium