title: Inhibition of ileal bile acid transporter: An emerging therapeutic strategy for chronic idiopathic constipation.
abstract: Chronic idiopathic constipation is a common disorder of the gastrointestinal tract that encompasses a wide profile of symptoms. Current treatment options for chronic idiopathic constipation are of limited value; therefore, a novel strategy is necessary with an increased effectiveness and safety. Recently, the inhibition of the ileal bile acid transporter has become a promising target for constipation-associated diseases. Enhanced delivery of bile acids into the colon achieves an accelerated colonic transit, increased stool frequency, and relief of constipation-related symptoms. This article provides insight into the mechanism of action of ileal bile acid transporter inhibitors and discusses their potential clinical use for pharmacotherapy of constipation in chronic idiopathic constipation.
authors.affiliation: Paula Mosińska, Jakub Fichna, Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92215 Lodz, Poland.
authors.forename: Paula
authors.initials: P
authors.lastname: Mosińska
authors.affiliation: Paula Mosińska, Jakub Fichna, Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92215 Lodz, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Fichna
authors.affiliation: Paula Mosińska, Jakub Fichna, Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92215 Lodz, Poland.
authors.forename: Martin
authors.initials: M
authors.lastname: Storr
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003248:Constipation / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D003672:Defecation / Q000187:drug effects*; D004151:Dipeptides / Q000627:therapeutic use*; D015195:Drug Design; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D058990:Molecular Targeted Therapy; D029363:Organic Anion Transporters, Sodium-Dependent / Q000037:antagonists & inhibitors* / Q000378:metabolism; D027981:Symporters / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013841:Thiazepines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D004151:Dipeptides; D005765:Gastrointestinal Agents; D029363:Organic Anion Transporters, Sodium-Dependent; D027981:Symporters; D013841:Thiazepines; C071908:sodium-bile acid cotransporter; C581303:elobixibat
keywords: Bile acids; Chronic idiopathic constipation; Ileal bile acid transporter