title: MicroRNA-410 promotes cell proliferation by targeting BRD7 in non-small cell lung cancer.
abstract: miR-410 acts as an oncogene or tumor suppressor gene in some malignancies. However, its role in NSCLC is still unknown. In this study, we showed that the expression of miR-410 was up-regulated in both human NSCLC tissues and cells. Overexpression of miR-410 promoted cell proliferation, migration, and invasion of NSCLC. In addition, bromodomain-containing protein 7 (BRD7) was a direct target of miR-410. MiR-410-mediated downregulation of BRD7 led to increase Akt phosphorylation. Inhibition of Akt phosphorylation can rescue the effect of miR-410 on NSCLC cell. The expression of BRD7 was downregulated in NSCLC and was inversely expressed with miR-410 in NSCLC. Our data provided new knowledge regarding the role of miR-410 in the lung cancer progression.
authors.affiliation: Department of General Internal Medicine, Chest Hospital of Hebei Province, Shijiazhuang, Hebei 050041, China.
authors.forename: Dengrui
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Pathology, Chest Hospital of Hebei Province, Shijiazhuang, Hebei 050041, China. Electronic address: yxht21@126.com.
authors.forename: YongHui
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Pathology, Chest Hospital of Hebei Province, Shijiazhuang, Hebei 050041, China.
authors.forename: GuiYun
authors.initials: G
authors.lastname: Zhu
authors.affiliation: The First Department of Oncology, Chest Hospital of Hebei Province, Shijiazhuang, Hebei 050041, China.
authors.forename: XinYan
authors.initials: X
authors.lastname: Liu
authors.affiliation: The Second Department of Oncology, Chest Hospital of Hebei Province, Shijiazhuang, Hebei 050041, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pathology, Chest Hospital of Hebei Province, Shijiazhuang, Hebei 050041, China.
authors.forename: XiaoXia
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, Chest Hospital of Hebei Province, Shijiazhuang, Hebei 050041, China.
authors.forename: QinOu
authors.initials: Q
authors.lastname: Yang
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000328:Adult; D001483:Base Sequence; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction / Q000235:genetics; D000092468:Bromodomain Containing Proteins
chemical_list: D020413:3' Untranslated Regions; D002868:Chromosomal Proteins, Non-Histone; D035683:MicroRNAs; D051057:Proto-Oncogene Proteins c-akt; C485694:BRD7 protein, human; D000092468:Bromodomain Containing Proteins; C568527:MIRN410 microRNA, human
keywords: Bromodomain-containing protein 7; Non-small cell lung cancer; miR-410; microRNA