title: Outcome of Isolated Premature Menarche: A Retrospective and Follow-Up Study.
abstract: OBJECTIVE
  Isolated premature menarche is isolated or recurrent vaginal bleeding in a female in the absence of appropriate secondary sexual characters.
  
  
  METHODS
  Retrospective chart review of patients with premature menarche, followed by a telephone questionnaire. Charts of patients evaluated in the Pediatric Endocrine Clinic for premature vaginal bleeding from 1982-2013 were reviewed.
  
  
  RESULTS
  Of 21 patients identified, 17 could be contacted. Five newly diagnosed patients were recruited during the course of the study. The median age at initial presentation was 7 years. Most patients presented with Tanner I sexual development. Some had more advanced breast staging, which regressed later. All had prepubertal baseline and stimulated gonadotropins. Most of the patients reported a single or few episodes of menses. Two reported continuation of irregular bleeding into adulthood. All reported an adult height within the midparental target height.
  
  
  CONCLUSIONS
  Premature menarche in the absence of other appropriate secondary sexual characteristics is a benign entity. Most patients have a few isolated episodes of menses that stop spontaneously; some may continue to have periods into adulthood. Unlike true puberty, these patients do not demonstrate advanced skeletal maturation, and the adult height is normal. Fertility appears to be normal.
authors.affiliation: Division of Pediatric Endocrinology, Stony Brook Children's Hospital, Stony Brook University, Stony Brook, N.Y., USA.
authors.forename: Sehar
authors.initials: S
authors.lastname: Ejaz
authors.forename: Andrew
authors.initials: A
authors.lastname: Lane
authors.forename: Thomas
authors.initials: T
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008572:Menarche / Q000502:physiology*; D008598:Menstruation / Q000502:physiology*; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D055815:Young Adult