title: Somatostatin receptor activation is involved in the control of daily torpor in a seasonal mammal.
abstract: Siberian hamsters (Phodopus sungorus) show spontaneous daily torpor only after ∼2 mo in winter-like short photoperiods (SP). Although some SP-induced hormonal changes have been demonstrated to be necessary for the occurrence of seasonal torpor, the whole set of preconditions is still unknown. Recent findings provide evidence that the hypothalamic pituitary growth axis is involved in endocrine responses to SP exposure in the photoperiodic hamsters. To examine whether suppression of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) secretion affects the incidence of daily torpor, we used two somatostatin receptor agonists, pasireotide (SOM230) and octreotide, with different affinity profiles for receptor subtypes. Pasireotide strikingly increased the torpor frequency in male hamsters compared with sham-treated controls, and torpor duration was often increased, which in some cases exceeded 12 h. In contrast, administration of octreotide reduced the body weight of SP hamsters but had only a marginal effect on torpor frequency in males and no effect in females. Together with measured concentrations of circulating IGF-1, the present results strongly suggest that reduced activity of the GH/IGF-1 axis is not critical for stimulation of torpor expression but activation of specific somatostatin receptors is critical. This putative role for certain somatostatin receptor subtypes in torpor induction provides a promising new approach to unravel the endocrine mechanisms of torpor regulation.
authors.affiliation: Department of Zoology, University of Veterinary Medicine Hannover, Hannover, Germany;
authors.forename: Frank
authors.initials: F
authors.lastname: Scherbarth
authors.affiliation: Department of Zoology, University of Veterinary Medicine Hannover, Hannover, Germany;
authors.forename: Victoria
authors.initials: V
authors.lastname: Diedrich
authors.affiliation: Rowett Institute for Nutrition and Health, Aberdeen, United Kingdom; and.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Dumbell
authors.affiliation: Oncology Department, Novartis Institutes for BioMedical Research, Basel, Switzerland.
authors.forename: Herbert A
authors.initials: HA
authors.lastname: Schmid
authors.affiliation: Department of Zoology, University of Veterinary Medicine Hannover, Hannover, Germany; stephan.steinlechner@tiho-hannover.de.
authors.forename: Stephan
authors.initials: S
authors.lastname: Steinlechner
authors.affiliation: Rowett Institute for Nutrition and Health, Aberdeen, United Kingdom; and.
authors.forename: Perry
authors.initials: P
authors.lastname: Barrett
mesh_terms: D000818:Animals; D001831:Body Temperature; D001835:Body Weight; D006224:Cricetinae; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D015282:Octreotide / Q000494:pharmacology; D017111:Phodopus; D012333:RNA, Messenger / Q000096:biosynthesis; D017481:Receptors, Somatostatin / Q000187:drug effects*; D012621:Seasons; D013004:Somatostatin / Q000031:analogs & derivatives / Q000494:pharmacology; D064348:Torpor / Q000187:drug effects*
chemical_list: D012333:RNA, Messenger; D017481:Receptors, Somatostatin; D013004:Somatostatin; C517782:pasireotide; D015282:Octreotide
keywords: GH/IGF-1 axis; octreotide; pasireotide (SOM230); seasonality; somatostatin receptors; torpor