title: Reactive Granulomatous Dermatitis: A Review of Palisaded Neutrophilic and Granulomatous Dermatitis, Interstitial Granulomatous Dermatitis, Interstitial Granulomatous Drug Reaction, and a Proposed Reclassification.
abstract: The terms "palisaded neutrophilic and granulomatous dermatitis," "interstitial granulomatous dermatitis," and the subset "interstitial granulomatous drug reaction" are a source of confusion. There exists substantial overlap among the entities with few strict distinguishing features. We review the literature and highlight areas of distinction and overlap, and propose a streamlined diagnostic workup for patients presenting with this cutaneous reaction pattern. Because the systemic disease associations and requisite workup are similar, and the etiopathogenesis is poorly understood but likely similar among these entities, we propose the simplified unifying term "reactive granulomatous dermatitis" to encompass these entities.
authors.affiliation: Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Misha.rosenbach@uphs.upenn.edu.
authors.forename: Misha
authors.initials: M
authors.lastname: Rosenbach
authors.affiliation: University of Pittsburgh, Department of Dermatology, UPMC North Hills Dermatology, Wexford, PA, USA.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: English
mesh_terms: D003872:Dermatitis / Q000145:classification* / Q000473:pathology; D003875:Drug Eruptions / Q000145:classification* / Q000473:pathology; D006099:Granuloma / Q000145:classification* / Q000473:pathology; D006801:Humans; D009504:Neutrophils; D012867:Skin / Q000473:pathology*
keywords: Granuloma annulare; Granulomatous dermatitis; Granulomatous drug reaction; Interstitial granulomatous dermatitis; Interstitial granulomatous drug reaction; Palisaded neutrophilic and granulomatous dermatitis; Reactive granulomatous dermatitis