title: Mn(II) mediated degradation of artemisinin based on Fe3O4@MnSiO3-FA nanospheres for cancer therapy in vivo.
abstract: Artemisinin (ART) is a natural drug with potent anticancer activities related with Fe(2+) mediated cleavage of the endoperoxide bridge in ART. Herein, we reported that Mn(2+) could substitute for Fe(2+) to react with ART and generate toxic products, inducing a much higher anticancer efficiency. On this basis, we prepared pH-responsive Fe3O4@MnSiO3-FA nanospheres which can efficiently deliver hydrophobic ART into tumors in mice models. Mn(2+) was released in acidic tumor environments and intracellular lysosomes, interacting with ART to kill cancer cells. The ART-loaded nanocarriers could suppress tumor growth more efficiently than free ART, which could be further illustrated by magnetic resonance imaging (MRI). Histological analysis revealed that the drug delivery system had no obvious effect on the major organs of mice. ART has been reported to have lower toxicity than chemotherapeutics. The ART-loaded nanocarriers are promising to be used in improving the survival of chemotherapy patients, providing a novel method for clinical tumor therapy.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Materials Science & Engineering, CAS High Magnetic Field Laboratory, University of Science and Technology of China, Hefei, 230026, China. cqw@ustc.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Weijie
authors.initials: W
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.forename: Haibao
authors.initials: H
authors.lastname: Wang
authors.forename: Mengni
authors.initials: M
authors.lastname: He
authors.forename: Pengping
authors.initials: P
authors.lastname: Xu
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhenbang
authors.initials: Z
authors.lastname: Liu
authors.forename: Qianwang
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D037621:Artemisinins / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D054118:Nanospheres / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D011859:Radiography; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D037621:Artemisinins; D004337:Drug Carriers; D008345:Manganese; C031327:artemisinin; D052203:Ferrosoferric Oxide