title: The Detection of Pancreatic and Retroperitoneal Plasmacytoma Helped to Diagnose Multiple Myeloma: A Case Report.
abstract: Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells producing a monoclonal protein. However, the involvement of pancreas is a rare event. We herein report a rare case of pancreatic plasmacytoma, which was detected before the diagnosis of multiple myeloma.An 83-year-old male was referred to our hospital for further evaluation of obstructive jaundice and a pancreatic mass. A contrast-enhanced computed tomography (CT) scan revealed solid masses with homogenous enhancement in the pancreatic head and retroperitoneum. The histological findings of the retroperitoneal mass obtained by CT-guided biopsy showed multiple sheets of atypical plasma cells, which were positively immunostained for CD79a, CD138, and the κ light chain. Serum immunoelectrophoresis detected M-component of immunoglobulin A-κ, and the histological findings of the bone marrow revealed an abnormally increased number of atypical plasma cells with irregular nuclei and cytoplasmic vacuolation. The patient was therefore diagnosed to have multiple myeloma involving the pancreas and retroperitoneum. Although chemotherapy was performed, the patient died 6 months after the diagnosis.The pancreatic plasmacytoma was detected before the multiple myeloma in the present case. It is difficult to diagnose a pancreatic plasmacytoma without a history of multiple myeloma and related disease.
authors.affiliation: From the Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Utsumi
authors.forename: Junpei
authors.initials: J
authors.lastname: Sasajima
authors.forename: Takuma
authors.initials: T
authors.lastname: Goto
authors.forename: Shugo
authors.initials: S
authors.lastname: Fujibayashi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Dokoshi
authors.forename: Aki
authors.initials: A
authors.lastname: Sakatani
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nomura
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ueno
authors.forename: Shin
authors.initials: S
authors.lastname: Kashima
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Inaba
authors.forename: Junki
authors.initials: J
authors.lastname: Inamura
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shindo
authors.forename: Kentaro
authors.initials: K
authors.lastname: Moriichi
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Fujiya
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kohgo
mesh_terms: D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D010954:Plasmacytoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D014057:Tomography, X-Ray Computed