title: Warfarin-related recurrent knee haemarthrosis treated with arterial embolisation and intra-articular injection of tranexamic acid.
abstract: Haemarthrosis is an uncommon complication of anticoagulation therapy. Tranexamic acid (TXA) has a high clinical value for the treatment of bleeding due to fibrinolysis. We describe a case of a 61-year-old woman with a mechanical heart valve who presented with warfarin-related recurrent haemarthrosis of her right knee, which recurred after transarterial embolisation. Intra-articular injection of TXA led to a cessation of haemarthrosis without any adverse event for 1 year. Intra-articular injection of TXA may be an effective treatment for warfarin-related haemarthrosis.
authors.affiliation: Department of Orthopaedic Surgery, Suita Municipal Hospital, Suita, Osaka, Japan.
authors.forename: Yasuo
authors.identifier: http://orcid.org/0000-0001-7934-6896
authors.initials: Y
authors.lastname: Kunugiza
authors.affiliation: Department of Orthopaedic Surgery, Suita Municipal Hospital, Suita, Osaka, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Radiology, Suita Municipal Hospital, Suita, Osaka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Mikami
authors.affiliation: Department of Orthopaedic Surgery, Suita Municipal Hospital, Suita, Osaka, Japan.
authors.forename: Shozo
authors.initials: S
authors.lastname: Suzuki
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D004621:Embolization, Therapeutic; D005260:Female; D006395:Hemarthrosis / Q000139:chemically induced / Q000150:complications / Q000628:therapy*; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000473:pathology*; D018810:Magnetic Resonance Angiography; D008875:Middle Aged; D012008:Recurrence; D014148:Tranexamic Acid / Q000008:administration & dosage*; D016896:Treatment Outcome; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D014859:Warfarin; D014148:Tranexamic Acid