title: In vitro evaluation of the antioxidant and antimicrobial activity of DIMBOA [2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one].
abstract: The aim of this study was to evaluate the in vitro antioxidant and antimicrobial properties of the natural cyclic hydroxamic acid: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA). Antioxidant activity of the isolated DIMBOA was examined using DPPH, FRAP and ABTS tests. It was found that DIMBOA exhibits a potent free-radical scavenging activity and a weaker iron (III) ions reducing activity. Antimicrobial activity against selected G(+), G(-) bacterial strains and against yeasts-like reference strains of fungi was investigated using disk-diffusion method. It has been shown that DIMBOA possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae.
authors.affiliation: a Department of Pharmacognosy , Wroclaw Medical University , Borowska 211 A, 50-556 Wrocław , Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Gleńsk
authors.affiliation: a Department of Pharmacognosy , Wroclaw Medical University , Borowska 211 A, 50-556 Wrocław , Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Gajda
authors.affiliation: b Department of Microbiology , Wroclaw Medical University , Chałubińskiego 4, 50-368 Wrocław , Poland.
authors.forename: Roman
authors.initials: R
authors.lastname: Franiczek
authors.affiliation: b Department of Microbiology , Wroclaw Medical University , Chałubińskiego 4, 50-368 Wrocław , Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Krzyżanowska
authors.affiliation: a Department of Pharmacognosy , Wroclaw Medical University , Borowska 211 A, 50-556 Wrocław , Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Biskup
authors.affiliation: a Department of Pharmacognosy , Wroclaw Medical University , Borowska 211 A, 50-556 Wrocław , Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Włodarczyk
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D048588:Benzoxazines / Q000494:pharmacology*; D001688:Biological Products; D004926:Escherichia coli / Q000187:drug effects; D016166:Free Radical Scavengers; D008826:Microbial Sensitivity Tests; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000975:Antioxidants; D048588:Benzoxazines; D001688:Biological Products; D016166:Free Radical Scavengers; C050733:2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one
keywords: ABTS; DIMBOA; DPPH; FRAP; Zea mays; antimicrobial; antioxidant