title: Antitumor quinazoline alkaloids from the seeds of Peganum harmala.
abstract: A phytochemical study on the methanol extracts from the seeds of Peganum harmala L. led to a new quizonaline alkaloid (S)-vasicinone-1-O-β-d-glucopyranoside (1) and four known ones, (R)-vasicinone-1-O-β-d-glucopyranoside (2), (S)-vasicinone (3), vasicine (4), and deoxyvasicinone (5). Their structures were elucidated by spectroscopic analysis including IR, HR-ESI-MS, 1D and 2D NMR, and specific rotation as well as by comparison of the data with those in the literature. All of the alkaloids were screened for antiproliferative activity against human gastric cancer cells MCG-803 with MTT method. Compounds 1 and 3 exhibited moderate inhibitory activity.
authors.affiliation: a School of Pharmaceutical Sciences, Wuhan University , Wuhan 430071 , China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Zeng
authors.forename: Yi-Hai
authors.initials: YH
authors.lastname: Wang
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Cheng
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Ye
authors.forename: Xiang-Jiu
authors.initials: XJ
authors.lastname: He
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032443:Peganum / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013274:Stomach Neoplasms / Q000188:drug therapy
chemical_list: C000601860:(S)-vasicinone-1-O-beta-D-glucopyranoside; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D011799:Quinazolines; C025696:2,3-trimethylene-4-quinazolone; C019592:vasicine; C052548:vasicinone
keywords: (S)-vasicinone-1-O-β-d-glucopyranoside; Peganum harmala; Zygophyllaceae; antiproliferative activity; quizonaline alkaloids