title: Clinical features and prognosis-associated factors of non-small cell lung cancer exhibiting symptoms of bone metastasis at the time of diagnosis.
abstract: The present study aimed to analyze the clinical characteristics and prognosis-related factors of non-small cell lung cancer (NSCLC) patients with bone metastases at the time of diagnosis. A total of 46 NSCLC patients with skeletal metastases at the time of diagnosis from Anhui Provincial Hospital and Anhui Provincial Cancer Hospital Affiliated to Anhui Medical University (Hefei, China) between February 2010 and February 2012 were investigated retrospectively. The median age was 58 years, with a range of 40-80 years, the ratio of males and females was 2:1, and adenocarcinoma and squamous cell carcinoma accounted for 71.7 and 28.3% of cases, respectively. Furthermore, 84.8% of patients exhibited multiple skeletal metastases at more than two sites and 54.3% of patients experienced skeletal-related events at the time of diagnosis. The median overall survival (OS) time of the patients was 237 days, and Kaplan-Meier analysis demonstrated that patients with adenocarcinoma (P=0.002), single bone metastases (P=0.023), an Eastern Cooperative Oncology Group performance status of 0-1 (P<0.001) or positive expression of estrogen receptor (ER)-β (P=0.039) exhibited significantly longer survival times. Furthermore, multivariate analysis identified the following independent predictors of OS: Tumor subtype (P=0.022), the number of bone metastases (P=0.016) and an ER-β-positive tumor (P=0.035). In the cohort of NSCLC patients with bone metastases at the time of diagnosis, adenocarcinoma and multiple skeletal metastases were most common.
authors.affiliation: Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical Univeristy, Hefei, Anhui 230001, P.R. China ; Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Yi-Fu
authors.initials: YF
authors.lastname: He
authors.affiliation: Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical Univeristy, Hefei, Anhui 230001, P.R. China.
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Luo
authors.affiliation: Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical Univeristy, Hefei, Anhui 230001, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical Univeristy, Hefei, Anhui 230001, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical Univeristy, Hefei, Anhui 230001, P.R. China.
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Yao
authors.affiliation: Department of Orthopedics, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Shan-Bao
authors.initials: SB
authors.lastname: Cai
authors.affiliation: Department of Pathology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Shu-Sheng
authors.initials: SS
authors.lastname: Wu
authors.affiliation: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Xiao-Xiu
authors.initials: XX
authors.lastname: Hu
authors.affiliation: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Ke
authors.affiliation: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Niu
authors.affiliation: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230001, P.R. China.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Li
authors.affiliation: Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical Univeristy, Hefei, Anhui 230001, P.R. China.
authors.forename: Chu-Shu
authors.initials: CS
authors.lastname: Ji
authors.affiliation: Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical Univeristy, Hefei, Anhui 230001, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
keywords: bone metastases; clinical characteristics; estrogen receptor-β; non-small cell lung cancer; prognostic factors