title: Efficient Synthesis of Single-Chain Globules Mimicking the Morphology and Polymerase Activity of Metalloenzymes.
abstract: Endowing unimolecular soft nanoobjects with biomimetic functions is attracting significant interest in the emerging field of single-chain technology. Inspired by the compartmentalized structure and polymerase activity of metalloenzymes, copper-containing compact nanoglobules have been designed, synthesized, and characterized endowed with metalloenzyme mimicking characteristics toward controlled synthesis of water-soluble polymers and thermoresponsive hydrogels. When compared to metalloenzymes, artificial nanoobjects endowed with metalloenzyme mimicking characteristics offer increased stability against thermal changes and reduced degradability by hydrolytic enzymes.
authors.affiliation: Centro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center, Paseo Manuel de Lardizábal 5, 20018, San Sebastián, Spain.|Departamento de Física de Materiales, Universidad del País Vasco (UPV/EHU), Apartado 1072, 20800, San Sebastián, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Sanchez-Sanchez
authors.affiliation: Centro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center, Paseo Manuel de Lardizábal 5, 20018, San Sebastián, Spain.
authors.forename: Arantxa
authors.initials: A
authors.lastname: Arbe
authors.affiliation: Laboratory for Neutron Scattering, Paul Scherrer Institut, CH-5232, Villigen, Switzerland.
authors.forename: Joachim
authors.initials: J
authors.lastname: Kohlbrecher
authors.affiliation: Centro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center, Paseo Manuel de Lardizábal 5, 20018, San Sebastián, Spain.|Departamento de Física de Materiales, Universidad del País Vasco (UPV/EHU), Apartado 1072, 20800, San Sebastián, Spain.|Donostia International Physics Center (DIPC), Paseo Manuel de Lardizabal 4, 20018, San Sebastián, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Colmenero
authors.affiliation: Centro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center, Paseo Manuel de Lardizábal 5, 20018, San Sebastián, Spain.|Departamento de Física de Materiales, Universidad del País Vasco (UPV/EHU), Apartado 1072, 20800, San Sebastián, Spain.|IKERBASQUE-Basque Foundation for Science, Maria Diaz de Haro 3, 48013, Bilbao, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Pomposo
mesh_terms: D004798:Enzymes / Q000378:metabolism*
chemical_list: D004798:Enzymes
keywords: ATRP; RAFT; metal-polymer complexes; nanoparticles; self-assembly