title: Prenatal exposure to polybrominated diphenyl ethers and birth outcomes.
abstract: This study aimed to examine the potential association between maternal PBDEs and birth outcomes, including birth weight (g), length (cm), head circumference (cm) and gestational age (week). 215 mothers were recruited from a prospective birth cohort in rural northern China between September 2010 and February 2012. Serum PBDE congeners were detected and their association with birth outcomes were examined. The median maternal serum concentrations of BDE-28, -47, -99, -100, -153 were 2.27, 2.26, 3.58, 2.13, 4.87 ng/g lipid, respectively. Maternal LgBDE-28 and LgBDE-100 were negatively associated with birth length (β = -0.92, 95% confidence interval (CI): -1.82, -0.02; β = -0.97, 95% CI: -1.83, -0.08). A negative association was found between LgBDE-28 and birth weight among male infants (β = -253.76, 95% CI: -438.16, -69.36). PBDE congeners were not associated with head circumference, or gestational age. Our results contribute to growing evidence suggesting that PBDEs have adverse effects on birth outcomes.
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Limei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Caifeng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Research Base of Key Laboratory of Surveillance and Early Warning on Infection Disease in China CDC, Shanghai Pudong New Area Center for Disease Control and Prevention, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Cui
authors.affiliation: Department of Pediatrics, Dongfang Hospital, Tongji University, Shanghai, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Ding
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: Gaoyu999@hotmail.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: tianmiejp@sjtu.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000328:Adult; D001724:Birth Weight; D002681:China; D005260:Female; D005865:Gestational Age; D055768:Halogenated Diphenyl Ethers / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D007223:Infant; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000503:physiopathology*; D011446:Prospective Studies; D012424:Rural Population
chemical_list: D055768:Halogenated Diphenyl Ethers
keywords: Birth outcomes; Infant development; Maternal exposure; Polybrominated diphenyl ethers