title: Incremental value of resting three-dimensional speckle-tracking echocardiography in detecting coronary artery disease.
abstract: The aim of the present study was to investigate the incremental value of resting three-dimensional speckle-tracking echocardiography (3D-STE) in the detection of early-stage left ventricular dysfunction in patients with coronary artery disease (CAD). A total of 110 patients suspected of having CAD were recruited. All patients underwent 3D-STE and coronary artery angiography (CAG). They were divided to a CAD group and a normal group according to the results of CAG. Using 3D-STE software, the peak values of longitudinal strain (LS), circumferential strain (CS), radial strain (RS) and area strain (AS) and the time to peak value of these strains (T-LS, T-CS, T-RS and T-AS) were measured. A receiver operator characteristic curve (ROC) was used to analyze the sensitivity of these strains for the diagnosis of CAD. ROC analysis indicated that T-LS and composite indices combining the peak strain value and time to peak of LS, CS and AS have diagnostic value for the early detection of CAD; the area under the curve (AUC) values were 0.667, 0.692, 0.621 and 0.672 respectively (P<0.005). The composite index of longitudinal strain demonstrated the highest diagnostic value for CAD with 62% sensitivity and 76% specificity. These results indicate that 3D-STE has incremental value for the diagnosis of CAD in patients at rest.
authors.affiliation: Department of Ultrasonography, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: You-Jing
authors.initials: YJ
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Rui-Sheng
authors.initials: RS
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Chen-Guang
authors.initials: CG
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Wei-Er
authors.initials: WE
authors.lastname: Zang
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Ming-Zhou
authors.initials: MZ
authors.lastname: Li
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
keywords: coronary artery disease; left ventricular dysfunction; strain; three-dimensional speckle-tracking echocardiography