title: High Residual Collagen-Induced Platelet Reactivity Predicts Development of Restenosis in the Superficial Femoral Artery After Percutaneous Transluminal Angioplasty in Claudicant Patients.
abstract: OBJECTIVE
  Although platelet reactivity is routinely inhibited with aspirin after percutaneous angioplasty (PTA) in peripheral arteries, the restenosis rate in the superficial femoral artery (SFA) is high. Interaction of activated platelets and the endothelium in the region of intervention could be one reason for this as collagen in the subendothelium activates platelets.
  
  
  METHODS
  A prospective study evaluating on-site platelet reactivity during PTA and its influence on the development of restenosis with a total of 30 patients scheduled for PTA of the SFA. Arterial blood was taken from the PTA site after SFA; platelet function was evaluated with light transmission aggregometry. After 3, 6, 12, and 24 months, duplex sonography was performed and the restenosis rate evaluated.
  
  
  RESULTS
  Eight out of 30 patients developed a hemodynamically relevant restenosis (>50 % lumen narrowing) in the PTA region during the 24-month follow-up period. High residual collagen-induced platelet reactivity defined as AUC >30 was a significant predictor for the development of restenosis [adjusted odds ratio 11.8 (9.4, 14.2); P = .04].
  
  
  CONCLUSIONS
  High residual collagen-induced platelet reactivity at the interventional site predicts development of restenosis after PTA of the SFA. Platelet function testing may be useful for identifying patients at risk.
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. thomas.gary@medunigraz.at.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gary
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. florian.prueller@klinikum-graz.at.|Research Unit for Perioperative Platelet Function Testing, Medical University of Graz, Graz, Austria. florian.prueller@klinikum-graz.at.
authors.forename: Florian
authors.initials: F
authors.lastname: Prüller
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. reinhard.raggam@klinikum-graz.at.|Research Unit for Perioperative Platelet Function Testing, Medical University of Graz, Graz, Austria. reinhard.raggam@klinikum-graz.at.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Raggam
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria. elisabeth.mahla@medunigraz.at.|Research Unit for Perioperative Platelet Function Testing, Medical University of Graz, Graz, Austria. elisabeth.mahla@medunigraz.at.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mahla
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. philipp.eller@medunigraz.at.
authors.forename: Philipp
authors.initials: P
authors.lastname: Eller
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. franz.hafner@klinikum-graz.at.
authors.forename: Franz
authors.initials: F
authors.lastname: Hafner
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. marianne.brodmann@medunigraz.at.
authors.forename: Marianne
authors.initials: M
authors.lastname: Brodmann
mesh_terms: D000368:Aged; D000792:Angiography; D017130:Angioplasty / Q000379:methods*; D001241:Aspirin / Q000008:administration & dosage; D001792:Blood Platelets / Q000502:physiology*; D003094:Collagen / Q000502:physiology*; D005260:Female; D005263:Femoral Artery; D006439:Hemodynamics; D006801:Humans; D007383:Intermittent Claudication / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D014463:Ultrasonography
chemical_list: D010975:Platelet Aggregation Inhibitors; D003094:Collagen; D001241:Aspirin