title: [The usefulness of prokinetics in the treatment of acid-related disease].
abstract: The main drugs for the acid-related disease are acid suppression agents, however, such treatment sometimes fail to obtain a satisfactory relief of symptoms. In primary care settings, it is usually difficult to discern the underlying pathophysiology of the putative acid-related symptoms whether excessive acid secretion or impaired gastrointestinal motility is involved. Prokinetic agents have the usefull effects such as the reduction in the gastroesophageal reflux episodes by increasing lower esophageal sphincter pressure, the improvement of esophageal clearance by strengthening esophageal peristalsis, the prevention of rise in intragastric pressure by ameliorating delayed gastric emptying and impaired accommodation, and the attenuation of visceral hypersensitivity by heightening the threshold to gastric distension, therefore, it is conceivable that prokinetic agents relief the acid-related symptoms via a different mechanism other than acid suppression agents. Prokinetic agents seem potent as an alternative or an additional drug in the treatment of acid-related symptoms when the acid suppression agents are ineffective.
authors.forename: Koji
authors.initials: K
authors.lastname: Nakada
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Hanyu
authors.forename: Norio
authors.initials: N
authors.lastname: Mitsumori
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
mesh_terms: D004415:Dyspepsia; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007700:Kinetics
chemical_list: D005765:Gastrointestinal Agents