title: Gold nanoparticles and vaccine development.
abstract: Mucosal vaccines constitute an advantageous immunization approach to achieve broad immunization against widespread diseases; however, improvements in this field are still required to expand their exploitation. As gold nanoparticles are biocompatible and can be easily functionalized with antigens, they have been proposed as carriers for the delivery of vaccines. The study of gold nanoparticles (AuNPs) in vaccinology has been of interest for a number of research groups in recent years and important advances have been made. This review provides a summary of the AuNPs synthesis methodologies and an updated overview of the current AuNPs-based vaccines under development. The implications of these advances for the development of new mucosal vaccines as well as future prospects for the field are discussed.
authors.affiliation: Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, SLP, 78210, México.
authors.forename: Jorge Alberto
authors.initials: JA
authors.lastname: Salazar-González
authors.forename: Omar
authors.initials: O
authors.lastname: González-Ortega
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosales-Mendoza
mesh_terms: D058956:Administration, Mucosal; D000818:Animals; D004337:Drug Carriers; D055808:Drug Discovery / Q000639:trends; D006046:Gold; D006801:Humans; D053758:Nanoparticles; D013678:Technology, Pharmaceutical / Q000639:trends; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D004337:Drug Carriers; D014612:Vaccines; D006046:Gold
keywords: antigen uptake; delivery vehicle; functionalization; immunogenicity; intranasal immunization; mucosal vaccine; nanoparticles; oral immunization; toxicity; vaccine cost