title: Two new glycosides isolated from Sapindus mukorossi fruits: effects on cell apoptosis and caspase-3 activation in human lung carcinoma cells.
abstract: Two new glycosides (1, 2) and two saponins (3, 4) were isolated from the fruits of Sapindus mukorossi Gaertn. The two glycosides were designated as sapindoside G (1) and 4'',4'''''-O-diacetylmukurozioside IIa (2). All four compounds exhibited inhibitory effects against A549 human lung adenocarcinoma cells with inhibition rates up to 69.2-83.3% at a concentration of 100 μg/mL. Flow cytometric analysis revealed that compounds 1-4 could suppress A549 cell growth by promoting cell apoptosis, which was related to the activation of caspase-3.
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-sen University (Higher Education Mega Center) , 132 Waihuan Rd East, Panyu District, Guangzhou 510006 , China.
authors.forename: Xuan-Ming
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-sen University (Higher Education Mega Center) , 132 Waihuan Rd East, Panyu District, Guangzhou 510006 , China.|b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou 510006 , China.
authors.forename: De-Po
authors.initials: DP
authors.lastname: Yang
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-sen University (Higher Education Mega Center) , 132 Waihuan Rd East, Panyu District, Guangzhou 510006 , China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Xie
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-sen University (Higher Education Mega Center) , 132 Waihuan Rd East, Panyu District, Guangzhou 510006 , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou 510006 , China.
authors.forename: Long-Ping
authors.initials: LP
authors.lastname: Zhu
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-sen University (Higher Education Mega Center) , 132 Waihuan Rd East, Panyu District, Guangzhou 510006 , China.|b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou 510006 , China.
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Zhao
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism*; D045744:Cell Line, Tumor; D004789:Enzyme Activation; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology*; D032127:Sapindus / Q000737:chemistry*; D012503:Saponins / Q000494:pharmacology
chemical_list: D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D053148:Caspase 3
keywords: Sapindus mukorossi; apoptosis; caspase-3; flow cytometric; glycosides; spectroscopic analysis