title: New Class of Heterogeneous Helical Peptidomimetics.
abstract: A new class of unnatural heterogeneous foldamers is reported to contain alternative α-amino acid and sulfono-γ-AA amino acid residues in a 1:1 repeat pattern. Two-dimensional NMR data show that two 1:1 α/sulfono-γ-AA peptides with diverse side chains form analogous right-handed helical structures in solution. The effects of sequence length, side chain, N-capping, and temperature on folding propensity were further investigated using circular dichroism and small-angle X-ray scattering.
authors.affiliation: †Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Haifan
authors.initials: H
authors.lastname: Wu
authors.affiliation: †Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Qiao
authors.affiliation: †Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Teng
authors.affiliation: †Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Yaogang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: †Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Antoniadis
authors.affiliation: ‡X-ray Science Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, United States.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zuo
authors.affiliation: †Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai