title: Antioxidant activity of taxifolin: an activity-structure relationship.
abstract: Taxifolin is a kind of flavanonol, whose biological ability. The objectives of this study were to investigate the antioxidants and antiradical activities of taxifolin by using different in vitro bioanalytical antioxidant methods including DMPD√(+), ABTS√(+), [Formula: see text], and DPPH√-scavenging effects, the total antioxidant influence, reducing capabilities, and Fe(2+)-chelating activities. Taxifolin demonstrated 81.02% inhibition of linoleic acid emulsion peroxidation at 30 µg/mL concentration. At the same concentration, standard antioxidants including trolox, α-tocopherol, BHT, and BHA exhibited inhibitions of linoleic acid emulsion as 88.57, 73.88, 94.29, and 90.12%, respectively. Also, taxifolin exhibited effective DMPD√(+), ABTS√(+), [Formula: see text], and DPPH√-scavenging effects, reducing capabilities, and Fe(2+)-chelating effects. The results obtained from this study clearly showed that taxifolin had marked antioxidant, reducing ability, radical scavenging and metal-chelating activities. Also, this study exhibits a scientific shore for the significant antioxidant activity of taxifolin and its structure-activity insight.
authors.affiliation: a Department of Medical Services and Techniques , Gumushane University, Vocational School of Health Services , Gumushane , Turkey .
authors.forename: Fevzi
authors.initials: F
authors.lastname: Topal
authors.affiliation: a Department of Medical Services and Techniques , Gumushane University, Vocational School of Health Services , Gumushane , Turkey .
authors.forename: Meryem
authors.initials: M
authors.lastname: Nar
authors.affiliation: b Central Researching Laboratory, Agri Ibrahim Cecen University , Agri , Turkey .
authors.forename: Hulya
authors.initials: H
authors.lastname: Gocer
authors.affiliation: c Department of Chemistry, Faculty of Sciences , Atatürk University , Erzurum-Turkey , and.
authors.forename: Pınar
authors.initials: P
authors.lastname: Kalin
authors.affiliation: c Department of Chemistry, Faculty of Sciences , Atatürk University , Erzurum-Turkey , and.
authors.forename: Umit M
authors.initials: UM
authors.lastname: Kocyigit
authors.affiliation: c Department of Chemistry, Faculty of Sciences , Atatürk University , Erzurum-Turkey , and.|d Department of Zoology, Fetal Programming of Diseases Research Chair , College of Science, King Saud University , Riyadh , Saudi Arabia.
authors.forename: İlhami
authors.initials: İ
authors.lastname: Gülçin
authors.affiliation: d Department of Zoology, Fetal Programming of Diseases Research Chair , College of Science, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Saleh H
authors.initials: SH
authors.lastname: Alwasel
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D011794:Quercetin; C003377:taxifolin
keywords: Antioxidant activity; radical scavenging; structure–activity insight; taxifolin