title: Post-operative steroid treatment for eosinophilic-type sinonasal polyposis.
abstract: CONCLUSIONS
  The preliminary finding of significantly lower eosinophilic-type CRSwNP recurrence rates in patients with associated asthma or ASA intolerance treated post-operatively with local nasal and oral steroids warrants further investigation in larger, prospective series.
  
  
  OBJECTIVE
  A high recurrence rate after functional endoscopic sinus surgery (FESS) has been widely reported in patients with eosinophilic-type chronic rhinosinusitis with nasal polyps (CRSwNP). This study compared the influence of two post-operative medical treatments - local nasal steroids alone vs local nasal and oral steroids - on the recurrence of eosinophilic-type CRSwNP.
  
  
  METHODS
  Between January 2009-December 2010, 32 patients with eosinophilic-type CRSwNP received local steroid nasal therapy after FESS (Group A); from January 2011 onwards, another 28 patients were treated post-operatively with the same nasal treatment plus two cycles a year of oral steroids (Group B). All patients in both groups had a follow-up of at least 36 months.
  
  
  RESULTS
  Groups A and B did not differ significantly in recurrence rate (31.25% vs 32.14%, p = 1) or disease-free interval (p = 0.91), but Group B patients who were asthmatic or ASA-intolerant had a significantly lower recurrence rate than Group A patients with asthma or ASA intolerance (p = 0.04 and p = 0.004, respectively).
authors.affiliation: a 1 Department of Neurosciences DNS, Otolaryngology Section, Padova University , Padova, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Brescia
authors.affiliation: a 1 Department of Neurosciences DNS, Otolaryngology Section, Padova University , Padova, Italy.
authors.forename: Gino
authors.initials: G
authors.lastname: Marioni
authors.affiliation: a 1 Department of Neurosciences DNS, Otolaryngology Section, Padova University , Padova, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Franchella
authors.affiliation: a 1 Department of Neurosciences DNS, Otolaryngology Section, Padova University , Padova, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ramacciotti
authors.affiliation: a 1 Department of Neurosciences DNS, Otolaryngology Section, Padova University , Padova, Italy.
authors.forename: Alfonso Luca
authors.initials: AL
authors.lastname: Pendolino
authors.affiliation: a 1 Department of Neurosciences DNS, Otolaryngology Section, Padova University , Padova, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Callegaro
authors.affiliation: b 2 Department of Medicine DIMED, Padova University , Padova, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Giacomelli
authors.affiliation: b 2 Department of Medicine DIMED, Padova University , Padova, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Marino
authors.affiliation: a 1 Department of Neurosciences DNS, Otolaryngology Section, Padova University , Padova, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martini
mesh_terms: D000281:Administration, Intranasal; D004724:Endoscopy; D004802:Eosinophilia / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D011182:Postoperative Care / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids
keywords: FESS; Sinonasal polyposis; eosinophilic-type; post-operative medical treatment; recurrence