title: Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole.
abstract: Herein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB) treatment in spite of low MIC levels (MIC: 0.5 mcg/mL). Both of the patients' blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7 mg/kg per day). After starting voriconazole blood cultures became negative and both of the patients were treated successfully without any side effects. In conclusion, although it is not a standard treatment in neonatal patients, our limited experience with these patients suggests that voriconazole appears to be a safe antifungal agent to be used in critically ill preterm infants with persistent fungemia despite AMB treatment.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Altuncu
authors.affiliation: Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Bilgen
authors.affiliation: Division of Pediatric Infectious Disease, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Soysal
authors.affiliation: Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, Turkey.
authors.forename: Eren
authors.initials: E
authors.lastname: Ozek