title: Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer.
abstract: The humoral innate immune system is composed of three major branches, complement, coagulation, and natural antibodies. To persist in the host, pathogens, such as bacteria, viruses, and cancers must evade parts of the innate humoral immune system. Disruptions in the humoral innate immune system also play a role in the development of autoimmune diseases. This review will examine how Gram positive bacteria, viruses, cancer, and the autoimmune conditions systemic lupus erythematosus and anti-phospholipid syndrome, interact with these immune system components. Through examining evasion techniques it becomes clear that an interplay between these three systems exists. By exploring the interplay and the evasion/disruption of the humoral innate immune system, we can develop a better understanding of pathogenic infections, cancer, and autoimmune disease development.
authors.affiliation: Division of Biology, College of Arts and Science, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: Trisha A
authors.initials: TA
authors.lastname: Rettig
authors.affiliation: Department of Diagnostic Medicine and Pathobiology College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: Julie N
authors.initials: JN
authors.lastname: Harbin
authors.affiliation: Division of Biology, College of Arts and Science, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: Adelaide
authors.initials: A
authors.lastname: Harrington
authors.affiliation: Division of Biology, College of Arts and Science, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: Leonie
authors.initials: L
authors.lastname: Dohmen
authors.affiliation: Division of Biology, College of Arts and Science, Kansas State University, Manhattan, KS 66506, USA. Electronic address: sdflemin@ksu.edu.
authors.forename: Sherry D
authors.initials: SD
authors.lastname: Fleming
mesh_terms: D000906:Antibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D015331:Cohort Studies; D003165:Complement System Proteins / Q000276:immunology; D016908:Gram-Positive Bacterial Infections / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D056724:Immunity, Humoral / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D019139:Tumor Escape / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D000906:Antibodies; D003165:Complement System Proteins
keywords: B1 B cells; Cancer; Coagulation; Complement; Natural antibodies; Pathogens; SLE