title: [COMT genetic variation and clinical response to antipsychotic drug treatment: A Meta-analysis].
abstract: OBJECTIVE
  To examine the relationship between COMT polymorphisms and the response to antipsychotic drugs, and then provide a basis for personalized medicine of antipsychotic drugs.
  
  
  METHODS
  We performed a systematic search from PubMed, Embase, Cochrane Library, CBM, CNKI, VIP and Wanfang database for eligible studies. Stata 12.0 was used for Meta-analysis after evaluating the quality of studies and collecting the data.
  
  
  RESULTS
  Nine studies included 868 participants met inclusion criteria. Significant association was found between the COMT Val108/158Met gene polymorphism and antipsychotic drug efficacy. Evaluating the therapeutic efficacy through general symptoms: Met vs Val, RR=1.18, 95% CI: 1.04-1.35, P=0.013; Met/Met vs Val/Val, RR=1.40, 95% CI: 1.08-1.82, P=0.010. Evaluating the therapeutic efficacy through negative symptoms: Met vs Val, RR=1.24, 95% CI: 1.05-1.46, P=0.013; Met/Met vs Val/Val, RR=1.60, 95% CI: 1.04-2.46, P=0.031.
  
  
  CONCLUSIONS
  COMT Val108/158Met gene polymorphism is significantly associated with antipsychotic drug efficacy, and Met gene is a dominant gene which displays a better response to antipsychotic drugs.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078,China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078,China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Tu
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078,China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ni
authors.affiliation: Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008,China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078;Clinical Drug Research and Statistical Analysis Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Linyong
authors.initials: L
authors.lastname: Xu
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D014150:Antipsychotic Agents; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase