title: [Pancytopenia, Hemolytic Anemia and Schizocytes: a Pragmatic Approach].
abstract: A 58 year old woman presents with a progressive fatigue and dyspnea associated with paresthesia. Laboratory tests show pancytopenia with hypersegmented neutrophiles, macrocytic hyporegenerative anemia and arguments for hemolysis, in particular highly increased LDH. This constellation strongly suggests vitamin B12 deficiency, which was confirmed with an undetectable cobalamine concentration in the blood of our patient. The etiologic work up shows the presence of anti-parietal cells antibodies at a titer of 1/640, diagnostic of Biermer anemia.
authors.affiliation: 1 Service de médecine interne et Service d'hématologie, Département de Médecine, Centre Hospitalier Universitaire Vaudois, Lausanne.
authors.forename: Nil
authors.initials: N
authors.lastname: Gökok
authors.forename: Grégoire
authors.initials: G
authors.lastname: Stalder
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Alberio
authors.forename: Olivier
authors.initials: O
authors.lastname: Lamy
authors.forename: Nora
authors.initials: N
authors.lastname: Schwotzer
mesh_terms: D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology*; D003937:Diagnosis, Differential; D004913:Erythrocytes, Abnormal / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010198:Pancytopenia / Q000097:blood / Q000209:etiology*; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000175:diagnosis*
keywords: Biermer; anemia; anémie; hemolysis; hypovitaminose B12; hémolyse; pancytopenia; pancytopénie; vitamin B12 deficiency