title: Forecasting new development of tumor areas using spatial and temporal distribution profiles of hemoglobin saturation in a mouse model.
abstract: Features of the tumor microenvironment (TME), such as hemoglobin saturation (HbSat), can provide valuable information on early development and progression of tumors. HbSat correlates with high metabolism and precedes the formation of angiogenic tumors; therefore, changes in HbSat profile can be used as a biomarker for early cancer detection. In this project, we develop a methodology to evaluate HbSat for forecasting early tumor development in a mouse model. We built a delta ([Formula: see text]) cumulative feature that includes spatial and temporal distribution of HbSat for classifying tumor/normal areas. Using a two-class (normal and tumor) logistic regression, the [Formula: see text] feature successfully forecasts tumor areas in two window chamber mice ([Formula: see text] and 0.85). To assess the performance of the logistic regression-based classifier utilizing the [Formula: see text] feature of each region, we conduct a 10-fold cross-validation analysis (AUC of the [Formula: see text]). These results show that the TME features based on HbSat can be used to evaluate tumor progression and forecast new occurrences of tumor areas.
authors.affiliation: University of Maryland Baltimore County , Department of Computer Science and Electrical Engineering, 1000 Hilltop Circle, Baltimore, Maryland 21250 ; National Cancer Institute , 9609 Medical Center Drive, Rockville, Maryland 20850.
authors.forename: Miguel R
authors.initials: MR
authors.lastname: Ossandon
authors.affiliation: University of Maryland Baltimore County , Department of Computer Science and Electrical Engineering, 1000 Hilltop Circle, Baltimore, Maryland 21250.
authors.forename: Dhananjay S
authors.initials: DS
authors.lastname: Phatak
authors.affiliation: National Cancer Institute , 9609 Medical Center Drive, Rockville, Maryland 20850.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Sorg
authors.affiliation: University of Maryland Baltimore County , Department of Computer Science and Electrical Engineering, 1000 Hilltop Circle, Baltimore, Maryland 21250.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kalpakis
keywords: hemoglobin saturation; image analysis; tumor angiogenesis; tumor microenvironment