title: A new approach for treatment of precancerous lesions with curcumin solid-lipid nanoparticle-loaded gels: in vitro and clinical evaluation.
abstract: OBJECTIVE
  Preparation and characterization of curcumin solid-lipid nanoparticle (CurSLN)-loaded mucoadhesive gel for local treatment of oral precancerous lesions with low dose.
  
  
  METHODS
  The formulated CurSLNs were dispersed in a mucoadhesive gel matrix to be applied to the buccal mucosa. Conventional mucoadhesive gel using binary system was adopted. The prepared gels were evaluated for in vitro drug dialysis, ex vivo mucoadhesion test and ex vivo permeation study using chicken buccal mucosa. Short-term clinical evaluation was carried out on 10 patients suffering oral erythroplakia in terms of pain index and lesion size measurement. (1) RESULTS: The results showed that the loaded gel with CurSLN showed good mucoadhesion property and 25 min in vivo residence time. In addition to stability enhancement for the Cur powder. All formulae did not show any drug permeated, however, significant amount of Cur was retained within the chicken buccal mucosal tissue confirmed by histological examination. Significant reduction in pain, and complete healing was observed after 6 weeks of treatment.
  
  
  CONCLUSIONS
  The local use of Cur in low dose is a promising option for treatment of precancerous lesions. The lack of local anti-inflammatory compounds with reduced side effects intensifies the importance of studying natural products for this purpose.
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing , Pharos University in Alexandria , Alexandria , Egypt .
authors.forename: Heba A
authors.initials: HA
authors.lastname: Hazzah
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing , Pharos University in Alexandria , Alexandria , Egypt .
authors.forename: Ragwa M
authors.initials: RM
authors.lastname: Farid
authors.affiliation: b Department of Pharmaceutics, Faculty of Pharmacy , and.
authors.forename: Maha M A
authors.initials: MM
authors.lastname: Nasra
authors.affiliation: c Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry , Alexandria University , Alexandria , Egypt.
authors.forename: Mennatallah
authors.initials: M
authors.lastname: Zakaria
authors.affiliation: c Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry , Alexandria University , Alexandria , Egypt.
authors.forename: Yousria
authors.initials: Y
authors.lastname: Gawish
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing , Pharos University in Alexandria , Alexandria , Egypt .
authors.forename: Magda A
authors.initials: MA
authors.lastname: El-Massik
authors.affiliation: b Department of Pharmaceutics, Faculty of Pharmacy , and.
authors.forename: Ossama Y
authors.initials: OY
authors.lastname: Abdallah
mesh_terms: D000268:Adhesiveness; D000818:Animals; D002645:Chickens; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D009061:Mouth Mucosa / Q000737:chemistry / Q000473:pathology*; D053758:Nanoparticles / Q000737:chemistry*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D004337:Drug Carriers; D005782:Gels; D008055:Lipids; D003474:Curcumin
keywords: Curcumin; mucoadhesive gel; precancerous lesions; solid–lipid nanoparticles