title: Bio-imaging and Photodynamic Therapy with Tetra Sulphonatophenyl Porphyrin (TSPP)-TiO2 Nanowhiskers: New Approaches in Rheumatoid Arthritis Theranostics.
abstract: Since Rheumatoid arthritis (RA) is one of the major human joint diseases with unknown etiology, the early diagnosis and treatment of RA remains a challenge. In this contribution we have explored the possibility to utilize novel nanocomposites of tetera suplhonatophenyl porphyrin (TSPP) with titanium dioxide (TiO2) nanowhiskers (TP) as effective bio-imaging and photodynamic therapeutic (PDT) agent for RA theranostics. Our observations demonstrate that TP solution PDT have an ameliorating effect on the RA by decreasing significantly the IL-17 and TNF-α level in blood serum and fluorescent imaging could enable us to diagnose the disease in subclinical stages and bio-mark the RA insulted joint.
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Fawad
authors.initials: F
authors.lastname: Ur Rehman
authors.affiliation: Daping Hospital, Third Military Medical University, Chongqing, 400042 P.R. China.
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: NanJing Foreign Language School, Nanjing 210096, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Chemistry and Biochemistry, California State University, Los Angeles, CA 90032, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Chemistry and Biochemistry, California State University, Los Angeles, CA 90032, USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Selke
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Daping Hospital, Third Military Medical University, Chongqing, 400042 P.R. China.
authors.forename: Chongyang
authors.initials: C
authors.lastname: Liu
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D016207:Cytokines / Q000097:blood; D003952:Diagnostic Imaging / Q000379:methods; D004195:Disease Models, Animal; D008297:Male; D053761:Nanocomposites; D061848:Optical Imaging / Q000379:methods; D010778:Photochemotherapy / Q000379:methods; D011166:Porphyrins; D051381:Rats; D000068936:Theranostic Nanomedicine / Q000379:methods; D014025:Titanium
chemical_list: D016207:Cytokines; D011166:Porphyrins; C009495:titanium dioxide; D014025:Titanium