title: A pathoanatomic approach to the management of mitral regurgitation.
abstract: Mitral regurgitation remains the most common global valvular heart disease. From otherwise unsuspecting healthy patients without overt symptoms to those with recalcitrant heart failure, mitral valve (MV) disease touches millions of patients per year. While MV prolapse without regurgitation remains benign, once regurgitation begins, quantification of severity is related to prognosis. Understanding the mechanism of regurgitation guides appropriate treatment. Current management guidelines emphasize early therapy after careful assessment of both anatomy and severity of mitral regurgitation. The objective of this review is to provide an update on the treatment of MV disease and to offer additional granularity on pathoanatomic decision making that may aid a more precise application of optimal guideline-directed therapy of primary and secondary mitral regurgitation.
authors.affiliation: The Center for Mitral Valve Disease, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address: badhwarv@upmc.edu.
authors.forename: Vinay
authors.initials: V
authors.lastname: Badhwar
authors.affiliation: The Center for Mitral Valve Disease, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Anson J C
authors.initials: AJ
authors.lastname: Smith
authors.affiliation: The Center for Mitral Valve Disease, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: João L
authors.initials: JL
authors.lastname: Cavalcante
mesh_terms: D000066491:Clinical Decision-Making / Q000379:methods; D019468:Disease Management; D042241:Early Diagnosis; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D017410:Practice Guidelines as Topic; D011379:Prognosis
keywords: Diagnosis; Management; Mitral regurgitation; Mitral valve disease; Surgery