title: Click chemistry-mediated catalytic hairpin self-assembly for amplified and sensitive fluorescence detection of Cu(2+) in human serum.
abstract: Chemically reduced Cu(2+) triggers the ligation of alkynyl- and azido-modified DNA via click chemistry. Subsequently, the ligated DNA initiates cyclic assembly of two fluorescently quenched hairpin DNAs and generates significantly amplified fluorescence signals for highly sensitive detection of Cu(2+) in human serum samples.
authors.affiliation: Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China. yunatswu@swu.edu.cn.
authors.forename: Daxiu
authors.initials: D
authors.lastname: Li
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Zhou
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Chai
authors.forename: Ruo
authors.initials: R
authors.lastname: Yuan
authors.forename: Yun
authors.initials: Y
authors.lastname: Xiang
mesh_terms: D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000097:blood* / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D006801:Humans; D055029:Inverted Repeat Sequences; D007477:Ions / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D007477:Ions; D003300:Copper; D004247:DNA