title: Clinicopathological features of plasmablastic multiple myeloma: a population-based cohort.
abstract: Multiple myeloma (MM) is a common malignant hematological disease displaying considerable heterogeneity. Historical data indicate a prognostic significance of plasmablastic morphology, proliferation, and adverse cytogenetics, but there is little knowledge on the degree of interdependency of these parameters. The aim of this study was to study the degree of overlap between these variables. In a consecutive population-based cohort of 194 untreated MM patients, morphology, and proliferation index, using immunohistochemical double staining for Ki-67 and CD138, was analyzed. In addition, cytogenetic changes were studied by karyotyping and fluorescence in situ hybridization (FISH). Plasmablastic morphology correlated with unfavorable clinical features, high proliferation index, high percentage of plasma cell infiltration in the bone marrow, abnormal karyotype, and del(13q) detected by karyotyping, which indicates that plasmablastic morphology reflects advanced and highly proliferative disease. However, plasmablastic morphology did not correlate with established adverse prognostic cytogenetics identified by FISH, for example, t(4;14), t(14;16) and del(17p).
authors.affiliation: Department of Pathology, Odense University Hospital, Odense, Denmark.
authors.forename: Hanne E H
authors.initials: HE
authors.lastname: Møller
authors.affiliation: Department of Pathology, Odense University Hospital, Odense, Denmark.
authors.forename: Birgitte S
authors.initials: BS
authors.lastname: Preiss
authors.affiliation: Department of Haematology, SVS Esbjerg, Esbjerg, Denmark.
authors.forename: Per
authors.initials: P
authors.lastname: Pedersen
authors.affiliation: Department of Haematology, Odense University Hospital, Odense, Denmark.
authors.forename: Ida B
authors.initials: IB
authors.lastname: Kristensen
authors.affiliation: Department of Haematology, Odense University Hospital, Odense, Denmark.
authors.forename: Charlotte T
authors.initials: CT
authors.lastname: Hansen
authors.affiliation: Department of Haematology, SHS Aabenraa, Aabenraa, Denmark.
authors.forename: Mikael
authors.initials: M
authors.lastname: Frederiksen
authors.affiliation: Department of Haematology, Odense University Hospital, Odense, Denmark.
authors.forename: Niels
authors.initials: N
authors.lastname: Abildgaard
authors.affiliation: Department of Pathology, Odense University Hospital, Odense, Denmark.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Møller
mesh_terms: D000328:Adult; D000368:Aged; D049109:Cell Proliferation; D003582:Cytogenetics / Q000379:methods; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping / Q000379:methods; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D017384:Sequence Deletion; D053668:Syndecan-1 / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; C508241:SDC1 protein, human; D053668:Syndecan-1
keywords: Multiple myeloma; antigen Ki-67; cytogenetic abnormalities; fluorescent in situ hybridization; plasmablastic myeloma