title: Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.
authors.affiliation: Cooperation Group of the Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) Jena and Ulm University (UULM), Ulm, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hartmann
authors.affiliation: Cooperation Group of the Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) Jena and Ulm University (UULM), Ulm, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Illing
authors.affiliation: Department of Pathology, University Hospital of Ulm, Ulm, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Leithäuser
authors.affiliation: Cooperation Group of the Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) Jena and Ulm University (UULM), Ulm, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Baisantry
authors.affiliation: Institute of Pathology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Quintanilla-Martinez
authors.affiliation: Cooperation Group of the Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) Jena and Ulm University (UULM), Ulm, Germany.|Faculty of Medicine, Research Group on Molecular Aging, University Hospital Jena (UKJ), Friedrich-Schiller-University (FSU), Jena, Germany.
authors.forename: K L
authors.initials: KL
authors.lastname: Rudolph
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D004249:DNA Damage; D004195:Disease Models, Animal; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D006579:Heterozygote; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008677:Metaphase; D051379:Mice; D015398:Signal Transduction; D016019:Survival Analysis; D016615:Telomere / Q000737:chemistry; D059506:Telomere Shortening; D034501:Telomere-Binding Proteins / Q000172:deficiency / Q000235:genetics*; D035321:Telomeric Repeat Binding Protein 1 / Q000172:deficiency / Q000235:genetics*
chemical_list: D034501:Telomere-Binding Proteins; D035321:Telomeric Repeat Binding Protein 1; C499083:Tinf2 protein, mouse