title: Amide Oxygen-Assisted Palladium-Catalyzed Hydration of Alkynes.
abstract: Herein, an amide oxygen-assisted palladium-catalyzed hydration reaction of alkynes is realized to prepare a series of o-acylacetanilide derivatives with high yield, and single regioselectivity under mild reaction conditions. This transformation is simple, practical, and can be performed on a gram scale. Evaluation of the mechanism shows that the reaction should involve an oxypalladation process, and the 1,3-oxazine compound is proven to be a key intermediate.
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
authors.forename: Zhenming
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.|‡College of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526060, P. R. China.
authors.forename: Lihuan
authors.initials: L
authors.lastname: Wu
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liao
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
authors.forename: Jianxiao
authors.initials: J
authors.lastname: Li
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Li