title: In Situ Synthesis of Magnetic Field-Responsive Hemicellulose Hydrogels for Drug Delivery.
abstract: A one-pot synthetic methodology for fabricating stimuli-responsive hemicellulose-based hydrogels was developed that consists of the in situ formation of magnetic iron oxide (Fe3O4) nanoparticles during the covalent cross-linking of O-acetyl-galactoglucomannan (AcGGM). The Fe3O4 nanoparticle content controlled the thermal stability, macrostructure, swelling behavior, and magnetization of the hybrid hydrogels. In addition, the magnetic field-responsive hemicellulose hydrogels (MFRHHs) exhibited excellent adsorption and controlled release profiles with bovine serum albumin (BSA) as the model drug. Therefore, the MFRHHs have great potential to be utilized in the biomedical field for tissue engineering applications, controlled drug delivery, and magnetically assisted bioseparation. Magnetic field-responsive hemicellulose hydrogels, prepared using a straightforward one-step process, expand the applications of biomass-derived polysaccharides by combining the renewability of hemicellulose and the magnetism of Fe3O4 nanoparticles.
authors.affiliation: †Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), Teknikringen 56-58 SE-100 44, Stockholm, Sweden.|‡College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, 610065, Chengdu, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Zhao
authors.affiliation: †Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), Teknikringen 56-58 SE-100 44, Stockholm, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Odelius
authors.affiliation: †Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), Teknikringen 56-58 SE-100 44, Stockholm, Sweden.
authors.forename: Ulrica
authors.initials: U
authors.lastname: Edlund
authors.affiliation: ‡College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, 610065, Chengdu, China.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Zhao
authors.affiliation: †Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), Teknikringen 56-58 SE-100 44, Stockholm, Sweden.
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Albertsson
mesh_terms: D000818:Animals; D002417:Cattle; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005290:Ferric Compounds; D020100:Hydrogels; D058185:Magnetite Nanoparticles; D011134:Polysaccharides; C000499:ferric oxide; D012710:Serum Albumin, Bovine; C007916:hemicellulose