title: The antioxidant properties of salicylate derivatives: A possible new mechanism of anti-inflammatory activity.
abstract: The synthesis and antioxidant evaluation by DPPH scavenging of a series of salicylic acid derivatives is described. Gentisic acid and its ester, amide, and amino analogs possess more radical scavenging capacity than salicylic acid and other salicylate derivatives. This property can possibly provide an additional pathway for anti-inflammatory activity through either single electron or hydrogen atom transfer, leading to a new strategy for the design of anti-inflammatory agents.
authors.affiliation: Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-110 Belém, PA, Brazil; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, United States. Electronic address: rosborg@ufpa.br.
authors.forename: Rosivaldo S
authors.initials: RS
authors.lastname: Borges
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, United States. Electronic address: scastle@chem.byu.edu.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Castle
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D011789:Quantum Theory; D020156:Salicylic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D020156:Salicylic Acid
keywords: Anti-inflammatory; Antioxidant mechanism; DFT; DPPH(); Salicylate derivatives