title: Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry.
abstract: The aim of this review is to provide a summary of the use of copper-catalyzed azide-alkyne cycloaddition (CuAAC) in the synthesis of porphyrin, chlorin and phthalocyanine derivatives for different types of therapeutic applications. The click reaction is a powerful and versatile tool for scientists working on the synthesis of various symmetrically and asymmetrically substituted tetrapyrrolic derivatives. For example, click chemistry is widely used for the elaboration of photosensitizer conjugates for photodynamic therapy applications. Other biological applications are also described.
authors.forename: Samir
authors.initials: S
authors.lastname: Acherar
authors.forename: Ludovic
authors.initials: L
authors.lastname: Colombeau
authors.forename: Céline
authors.initials: C
authors.lastname: Frochot
authors.affiliation: Laboratoire de Chimie Physique Macromoleculaire (LCPM), Universite de Lorraine - CNRS, UMR 7375, 1 rue Grandville BP 20451, 54001 Nancy cedex, France. regis.vanderesse@univ-lorraine.fr.
authors.forename: Régis
authors.initials: R
authors.lastname: Vanderesse
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D057930:Click Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D054833:Isoindoles; D015394:Molecular Structure; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D007211:Indoles; D054833:Isoindoles; D011166:Porphyrins; C006969:chlorin; C013647:phthalocyanine