title: Matrix Metalloproteinase 9 Gene Promoter (rs 3918242) Mutation Reduces the Risk of Diabetic Microvascular Complications.
abstract: BACKGROUND
  Many studies have evaluated the association between matrix metalloproteinase 9 (MMP9) gene promoter polymorphism and diabetic microvascular complications. However, the results are conflicting and inconclusive. The aim of this meta-analysis was to evaluate the association more precisely.
  
  
  METHODS
  Studies were retrieved from the PubMed, Embase, Medline, China National Knowledge Infrastructure, Web of Science, and Cochrane databases. All statistical analyses were performed using Review Manager 5.2.
  
  
  RESULTS
  Data were abstracted from four case-control studies that included 446 patients with diabetic microvascular complications and 496 diabetic control subjects. The MMP9-1562 C/T genotype was significantly associated with the risk of diabetic nephropathy after stratification by specific type of microvascular complication (CT + TT vs. CC: OR = 0.42, 95% CI = 0.26-0.69, p = 0.0006; TT vs. CC + CT: OR = 0.37, 95% CI = 0.19-0.76, p = 0.006).
  
  
  CONCLUSIONS
  This study adds to the evidence that MMP9-1562 T gene mutation might reduce the risk of diabetic nephropathy.
authors.affiliation: Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, China. zhangzhongwen521@126.com.|Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China. zhangzhongwen521@126.com.
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China. jkeliya@163.com.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Wu
authors.affiliation: Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China. caitianzhi900205@163.com.
authors.forename: Tian
authors.initials: T
authors.lastname: Cai
authors.affiliation: Department of Cadres Healthcare, Qilu Hospital of Shandong University, Qingdao 266035, China. gaoweiyiqdql@sina.com.
authors.forename: Weiyi
authors.initials: W
authors.lastname: Gao
authors.affiliation: Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China. 1989919zm@163.com.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China. junyuzhao07@gmail.com.
authors.forename: Junyu
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China. jinmingvvip@sina.com.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yao
authors.affiliation: Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China. shanghongxia1989@foxmail.com.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Shang
authors.affiliation: Division of Endocrinology, Department of Medicine, Qilu Hospital of Shandong University, Jinan 250012, China. dongjianjun@medmail.com.cn.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Dong
authors.affiliation: Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China. liaolin009@sina.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Liao
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China; D003925:Diabetic Angiopathies / Q000517:prevention & control*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012306:Risk
chemical_list: D020780:Matrix Metalloproteinase 9
keywords: diabetes mellitus; matrix metalloproteinase 9; meta-analysis