title: Development and functions of the choroid plexus-cerebrospinal fluid system.
abstract: The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates. Various animal models have provided insights into how the ChP-CSF system develops and matures. In addition, recent studies have uncovered new, active roles for this dynamic system in the regulation of neural stem cells, critical periods and the overall health of the nervous system. Together, these findings have brought about a paradigm shift in our understanding of brain development and health, and have stimulated new initiatives for the treatment of neurological disease.
authors.affiliation: 1] Department of Pathology, Boston Children's Hospital, Boston, Massachusetts 02115, USA. [2] Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
authors.forename: Melody P
authors.initials: MP
authors.lastname: Lun
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, Irvine, California 92697, USA.
authors.forename: Edwin S
authors.initials: ES
authors.lastname: Monuki
authors.affiliation: Department of Pathology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Maria K
authors.initials: MK
authors.lastname: Lehtinen
mesh_terms: D000818:Animals; D002555:Cerebrospinal Fluid / Q000502:physiology*; D002831:Choroid Plexus / Q000254:growth & development* / Q000502:physiology*; D006801:Humans