title: Visual Acuity in Birdshot Retinochoroidopathy Evaluation.
abstract: OBJECTIVE
  To determine the statistical correlation between visual acuity (VA) and various quantitative parameters relevant to birdshot retinochoroidopathy (BRC) evaluation.
  
  
  METHODS
  Hospital-based retrospective observational study.
  
  
  METHODS
  setting: Institutional.
  
  
  METHODS
  Consecutive HLA29+ BRC patients were included between May and August 2013 at a single tertiary center (Pitié-Salpétrière Hospital, Paris).
  
  
  METHODS
  Demographic data and quantitative parameters relevant to BRC at baseline were collected: VA, degree of anterior and posterior inflammatory reaction, foveal thickness measured by optical coherence tomography (OCT), Arden ratio, and electrooculography (EOG) light peak.
  
  
  METHODS
  Correlation between VA and the other parameters of the ipsilateral and fellow eye was performed using Spearman rank correlation coefficients.
  
  
  RESULTS
  Fifty-five patients were included. Mean VA was 6/9.5 in the right eye (OD) and 6/12 in the left eye (OS). Mean foveal thickness was 240 μm OD (range: 112-606) and 251 μm OS (range: 85-662). Mean Arden ratio was 159% OD and 160% OS. EOG light peak was 714 mV OD (range: 316-1379) and 746 mV OS (range: 272-1652). VA of a given eye was moderately correlated with VA of the contralateral eye (r = 0.4). On the contrary, all other parameters showed a strong correlation between both eyes (all r > 0.7, P < .01). Overall, none of the studied parameters was correlated with its VA (all r < 0.5).
  
  
  CONCLUSIONS
  In BRC, visual acuity alone does not seem to fully reflect the disease severity in terms of clinical or ancillary quantitative findings at baseline.
authors.affiliation: Ophthalmology Department, Reference Center in Rare Diseases, DHU Sight Restore, Hôpital Pitié Salpêtrière, University Paris VI, Paris, France. Electronic address: saratouhami@gmail.com.
authors.forename: Sara
authors.initials: S
authors.lastname: Touhami
authors.affiliation: Ophthalmology Department, Reference Center in Rare Diseases, DHU Sight Restore, Hôpital Pitié Salpêtrière, University Paris VI, Paris, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Fardeau
authors.affiliation: AP-HP, University Hospital Pitié-Salpêtrière Charles-Foix, Department of Biostatistics Public Health and Medical Informatics, Paris, France; Sorbonne Universités, UPMC, Université Paris 6, Department of Biostatistics, Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Vanier
authors.affiliation: Ophthalmology Department, Reference Center in Rare Diseases, DHU Sight Restore, Hôpital Pitié Salpêtrière, University Paris VI, Paris, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Knoeri
authors.affiliation: Ophthalmology Department, Reference Center in Rare Diseases, DHU Sight Restore, Hôpital Pitié Salpêtrière, University Paris VI, Paris, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Simon
authors.affiliation: AP-HP, University Hospital Pitié-Salpêtrière Charles-Foix, Department of Biostatistics Public Health and Medical Informatics, Paris, France; Sorbonne Universités, UPMC Université Paris 6, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique, Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Tezenas du Montcel
authors.affiliation: Ophthalmology Department, CHU Kremlin-Bicetre, Le Kremlin-Bicêtre, France.
authors.forename: Yacine
authors.initials: Y
authors.lastname: Troumani
authors.affiliation: Ophthalmology Department, Reference Center in Rare Diseases, DHU Sight Restore, Hôpital Pitié Salpêtrière, University Paris VI, Paris, France.
authors.forename: Bahram
authors.initials: B
authors.lastname: Bodaghi
authors.affiliation: Ophthalmology Department, Reference Center in Rare Diseases, DHU Sight Restore, Hôpital Pitié Salpêtrière, University Paris VI, Paris, France.
authors.forename: Phuc
authors.initials: P
authors.lastname: Le Hoang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000080365:Birdshot Chorioretinopathy; D002825:Chorioretinitis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D004585:Electrooculography; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D015234:HLA-A Antigens / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests
chemical_list: D005938:Glucocorticoids; D015234:HLA-A Antigens; C035524:HLA-A29 antigen; D007166:Immunosuppressive Agents