title: Plasma iron, C-reactive protein, albumin, and plasma fibrinogen concentrations in dogs with systemic inflammatory response syndrome.
abstract: OBJECTIVE
  To investigate the diagnostic and prognostic value over time of plasma iron compared with the inflammatory markers albumin, C-reactive protein (CRP), and fibrinogen in dogs with systemic inflammatory response syndrome (SIRS).
  
  
  METHODS
  Prospective observational study of sequentially enrolled dogs.
  
  
  METHODS
  ICU of a veterinary teaching hospital.
  
  
  METHODS
  One hundred and sixteen client-owned dogs: 54 dogs with SIRS or sepsis, 42 with focal inflammation, and 20 clinically healthy dogs.
  
  
  RESULTS
  Blood samples were obtained on admission in all study groups, and then on alternate days until discharge or death in both inflammation groups. On admission, dogs with SIRS had significantly lower plasma iron (65 ± 5.8 μg/dL, P = 0.001) concentrations than dogs with focal inflammation (89.5 ± 6.2 μg/dL, P = 0.001). Plasma iron, albumin, and CRP effectively discriminated the SIRS/sepsis group from those presenting with focal inflammation with areas under the curve for the receiver operating curves of 0.679, 0.834, and 0.704, respectively. The admission values for these variables did not discriminate survivors from nonsurvivors within the SIRS/sepsis group. However, the magnitude of increase in iron concentration and the decrease in CRP concentration from admission to hospital discharge was higher in survivors than in nonsurvivors within the SIRS/septic group (22.8 vs. 2.51 μg/dL, respectively, P = 0.021 for iron; -67.1 vs. -4.1 mg/L, respectively, P = 0.002 for CRP), resulting in iron and CRP concentrations at hospital discharge for survivors similar to those in the focal inflammation group.
  
  
  CONCLUSIONS
  Hypoferremia is a sensitive marker of systemic inflammation in dogs. In this study, the increase in iron concentrations during the hospitalization period of SIRS/septic dogs was associated with a better prognosis, suggesting that plasma iron in combination with CRP and albumin concentrations might be used to monitor dogs with inflammatory disease processes.
authors.affiliation: Servei d'Emergències i Cures Intensives FHCV-UAB, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.|Departament de Medicina i Cirurgia Animals, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Torrente
authors.affiliation: the Departament de Ciència Animal i dels Aliments, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Edgar G
authors.initials: EG
authors.lastname: Manzanilla
authors.affiliation: Servei d'Emergències i Cures Intensives FHCV-UAB, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.|Departament de Medicina i Cirurgia Animals, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Bosch
authors.affiliation: Departament de Medicina i Cirurgia Animals, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Fresno
authors.affiliation: Departament de Medicina i Cirurgia Animals, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Rivera Del Alamo
authors.affiliation: Departament de Medicina i Cirurgia Animals, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Andaluz
authors.affiliation: Departament de Bioquímica i Biologia molecular, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Saco
authors.affiliation: Departament de Medicina i Cirurgia Animals, Facultat de Veterinària de la UAB, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Ruiz de Gopegui
mesh_terms: D000818:Animals; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood* / Q000378:metabolism; D004285:Dogs; D005340:Fibrinogen / Q000378:metabolism*; D006490:Hemostatics; D007249:Inflammation; D007501:Iron / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood / Q000378:metabolism / Q000662:veterinary; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000378:metabolism / Q000662:veterinary*
chemical_list: D015415:Biomarkers; D006490:Hemostatics; D005340:Fibrinogen; D002097:C-Reactive Protein; D007501:Iron
keywords: acute phase proteins; hypoferremia; inflammation; outcome