title: The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease.
abstract: It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of Aβ42 and normal levels of CSF neurofilament light protein and sAPPα and sAPPβ, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.
authors.affiliation: Department of Infectious Diseases, Gävle Hospital, Gävle, Sweden.
authors.forename: Signar
authors.initials: S
authors.lastname: Mäkitalo
authors.affiliation: Clinic of Infectious Diseases, South Älvsborg Hospital, Borås, Sweden ; Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Åsa
authors.initials: Å
authors.lastname: Mellgren
authors.affiliation: Department of Respiratory Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Ellen
authors.initials: E
authors.lastname: Borgh
authors.affiliation: Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
authors.forename: Lena
authors.initials: L
authors.lastname: Kilander
authors.affiliation: Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
authors.forename: Tobias
authors.initials: T
authors.lastname: Skillbäck
authors.affiliation: Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden ; UCL Institute of Neurology, Queen Square, London, UK.
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.affiliation: Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Gisslén
keywords: Alzheimer’s disease; CSF biomarkers; HIV