title: Impact of B-type natriuretic peptide (BNP) on development of atrial fibrillation in people with Type 2 diabetes.
abstract: To examine if a simple biomarker can identify people with diabetes who are at high risk of atrial fibrillation.
  
  
  
  A retrospective cohort study was conducted at a single centre in people with Type 2 diabetes referred to our department between January 2000 and December 2007. In 517 consecutive people without any history, signs or symptoms of atrial fibrillation at baseline, the association between baseline B-type natriuretic peptide level and future atrial fibrillation incidence was examined, with adjustments for other potentially confounding factors.
  
  
  
  A total of 28 people were diagnosed with new-onset atrial fibrillation during a median 6-year follow-up. When people were categorized into three groups according to B-type natriuretic peptide clinical thresholds (20 and 100 pg/ml), hazard ratios for the development of atrial fibrillation in the middle and highest B-type natriuretic peptide groups were 2.8 and 9.4, respectively, compared with the lowest B-type natriuretic peptide group. Time-dependent receiver-operating curve analysis identified a threshold for B-type natriuretic peptide to detect atrial fibrillation development of 52.8 pg/ml (sensitivity 75.2%, specificity 68.8%). The B-type natriuretic peptide predictive value was independent of and similar to that of left atrial size and ventricular dimension.
  
  
  
  In people with Type 2 diabetes, high baseline B-type natriuretic peptide levels were significantly associated with future atrial fibrillation development.
authors.affiliation: Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kishimoto
authors.affiliation: Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.affiliation: Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohata
authors.affiliation: Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tamanaha
authors.affiliation: Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tochiya
authors.affiliation: Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kusano
authors.affiliation: Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Anzai
authors.affiliation: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Toyoda
authors.affiliation: Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yasuda
authors.affiliation: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Minematsu
authors.affiliation: Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000453:epidemiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D016016:Proportional Hazards Models; D012189:Retrospective Studies
chemical_list: D020097:Natriuretic Peptide, Brain