title: Diagnosis of adenoid cystic carcinoma of the breast using fine-needle aspiration cytology: A case report and review of the literature.
abstract: Adenoid cystic carcinoma (ACC) of the breast is a rare variant of breast malignancy and is associated with an excellent prognosis. ACC accounts for 0.1% of all breast carcinomas. It has favorable biological characteristics and an excellent prognosis. A 77-year-old woman presented with a lump in the right breast. Ultrasonography and mammography showed a 12-mm, well-defined, lobulated mass in the retroareolar region of the right breast. The lump was diagnosed as ACC on the basis of immunohistochemical staining results for c-kit (CD117), muscle-specific actin, p63, estrogen receptor, and progesterone receptor using a fine-needle aspiration cytology (FNAC) specimen. This diagnosis was subsequently confirmed by excision biopsy. To the best of our knowledge, this is the first case of ACC of the breast to date to be diagnosed on the basis of immunohistochemical staining of an FNAC cell block material. From our experience, we recommend the usage of cell block material for immunohistochemical studies to accurately diagnose ACC of the breast.
authors.affiliation: Department of Pathology, Umraniye Education and Research Hospital, Istanbul, Turkey.
authors.forename: Tosun M
authors.initials: TM
authors.lastname: Ilkay
authors.affiliation: Department of Pathology, Umraniye Education and Research Hospital, Istanbul, Turkey.
authors.forename: Kir
authors.initials: K
authors.lastname: Gozde
authors.affiliation: Department of Radiology, Umraniye Education and Research Hospital, Istanbul, Turkey.
authors.forename: Sarica
authors.initials: S
authors.lastname: Ozgur
authors.affiliation: Department of Pathology, GATA Haydarpasa Education Hospital, Istanbul, Turkey.
authors.forename: Demirel
authors.initials: D
authors.lastname: Dilaver
mesh_terms: D000199:Actins / Q000032:analysis; D000368:Aged; D044963:Biopsy, Fine-Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008327:Mammography; D008565:Membrane Proteins / Q000032:analysis; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D000199:Actins; C081876:CKAP4 protein, human; D008565:Membrane Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: FNAC; adenoid cystic carcinoma; breast cytopathology