title: Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury.
abstract: The degree of post-traumatic brain edema and dysfunction of the blood-brain barrier (BBB) influences the neurofunctional outcome after a traumatic brain injury (TBI). Previous studies have demonstrated that the administration of apolipoprotein E-mimetic peptide COG1410 reduces the brain water content after subarachnoid hemorrhage, intra-cerebral hemorrhage, and focal brain ischemia. However, the effects of COG1410 on vasogenic edema following TBI are not known. The current study evaluated the effects of 1 mg/kg daily COG1410 versus saline administered intravenously after a controlled cortical impact (CCI) injury on BBB dysfunction and vasogenic edema at an acute stage in mice. The results demonstrated that treatment with COG1410 suppressed the activity of matrix metalloproteinase-9, reduced the disruption of the BBB and Evans Blue dye extravasation, reduced the TBI lesion volume and vasogenic edema, and decreased the functional deficits compared with mice treated with vehicle, at an acute stage after CCI. These findings suggest that COG1410 is a promising preclinical therapeutic agent for the treatment of traumatic brain injury.
authors.affiliation: 1 Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University , Chongqing, China .
authors.forename: Fang
authors.initials: F
authors.lastname: Cao
authors.affiliation: 2 Department of Neurosurgery, the Affiliated Hospital of Luzhou Medical College , Luzhou, China .
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: 1 Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University , Chongqing, China .
authors.forename: Yue
authors.initials: Y
authors.lastname: Wu
authors.affiliation: 1 Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University , Chongqing, China .
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhong
authors.affiliation: 2 Department of Neurosurgery, the Affiliated Hospital of Luzhou Medical College , Luzhou, China .
authors.forename: Jieshi
authors.initials: J
authors.lastname: Liu
authors.affiliation: 2 Department of Neurosurgery, the Affiliated Hospital of Luzhou Medical College , Luzhou, China .
authors.forename: Xinghu
authors.initials: X
authors.lastname: Qin
authors.affiliation: 2 Department of Neurosurgery, the Affiliated Hospital of Luzhou Medical College , Luzhou, China .
authors.forename: Ligang
authors.initials: L
authors.lastname: Chen
authors.affiliation: 3 Department of Medicine (Neurology), Duke University Medical Center , Durham, North Carolina.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Vitek
authors.affiliation: 4 Cognosci Inc. , Research Triangle Park, North Carolina.
authors.forename: Fengqiao
authors.initials: F
authors.lastname: Li
authors.affiliation: 5 Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University , Chongqing, China .
authors.forename: Lu
authors.initials: L
authors.lastname: Xu
authors.affiliation: 1 Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University , Chongqing, China .
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy*; D004195:Disease Models, Animal; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D020127:Recovery of Function / Q000187:drug effects*
chemical_list: D001057:Apolipoproteins E; C524548:COG1410; D020780:Matrix Metalloproteinase 9; C501830:Mmp9 protein, mouse
keywords: COG1410; apolipoprotein E; blood–brain barrier; controlled cortical impact injury; traumatic brain injury; vasogenic edema