title: Five in one therapy for graded treatment of haemophilic arthritis.
abstract: BACKGROUND
  Haemophilic arthritis is the most universal clinical appearance of haemophilia. Treatment of this disease has become an important and difficult issue worldwide until recently.
  
  
  OBJECTIVE
  To investigate the efficacy and safety of five in one therapy for graded treatment of haemophilic arthritis.
  
  
  METHODS
  Haemophilic arthritis was classified into grades I-IV according to severity and the standards of De Palma and Cotler. Under no application of FVIII/FIX replacement therapy state, the effect of five in one therapy (intra-articular cavity drug injection, oral drug preparation, physiotherapy, and prevention of haemorrhage and infection evoked by puncture) was observed in 1527 affected joints of 750 cases of haemophilic arthritis.
  
  
  RESULTS
  After 20 days treatment, all grade I and II, 94.98% of grade III and 56.16% of grade IV affected joints were completely relieved; 5.02% of grade III and 41.47% of grade IV affected joints were basically relieved; and 2.38% of grade IV were partially relieved. This resulted in short-term complete and basic relief of 98.56% (1505/1527) of all affected joints. After follow-up of 1-6 years, 86.97% of the affected joints were completely relieved, without any adverse reaction or complication.
  
  
  CONCLUSIONS
  The results suggest that five in one therapy is safe and effective for treatment of haemophilic arthritis, and provides a convenient, cost-effective way of preventing and treating deformity caused by haemophilic arthritis.
authors.affiliation: Shaanxi Yida Hemophilia Institute, Xi'an, Shaanxi, China.
authors.forename: S X
authors.initials: SX
authors.lastname: Liu
authors.affiliation: Shaanxi Yida Hemophilia Institute, Xi'an, Shaanxi, China.
authors.forename: P B
authors.initials: PB
authors.lastname: Li
authors.affiliation: Shaanxi Yida Hemophilia Institute, Xi'an, Shaanxi, China.
authors.forename: Y G
authors.initials: YG
authors.lastname: Liu
authors.affiliation: Shaanxi Yida Hemophilia Institute, Xi'an, Shaanxi, China.
authors.forename: P H
authors.initials: PH
authors.lastname: Wang
keywords: five in one therapy; graded treatment; haemophilic arthritis