title: α-Galacto-oligosaccharides Dose-Dependently Reduce Appetite and Decrease Inflammation in Overweight Adults.
abstract: BACKGROUND
  Dietary fibers have been associated with a reduction in appetite and energy intake. Although a few studies suggest that nonviscous fibers can exert such effects, likely through colonic fermentation, limited data are available.
  
  
  OBJECTIVE
  The objective of this study was to determine whether α-galacto-oligosaccharides (α-GOSs), fermentable soluble fibers extracted from legumes, could reduce appetite, food intake, and inflammation in overweight subjects.
  
  
  METHODS
  In 2 single-center, double-blind, randomized, placebo-controlled trials, 88 overweight adults [50% men and 50% women; 18-60 y old; body mass index (in kg/m(2)): 25-28] were supplemented for 14 d with tea that contained α-GOSs with different α-GOS dosages (6, 12, or 18 g α-GOSs/d), formulas (12 g α-GOSs/d with >80% of molecules with a degree of polymerization of 2, 3, or 4), or a control substance (glucose syrup). Appetite scores (5 appetite dimensions were assessed on visual analog scales during a preload test meal), food intake (test meal and 24-h food recall), and inflammatory markers [plasma lipopolysaccharide (LPS) and C-reactive protein (CRP)] were evaluated at day 0 (baseline) and day 15.
  
  
  RESULTS
  Changes in appetite scores from day 0 to day 15 were significantly higher after α-GOS intake, with areas under the curve for the satiety score of +121 ± 108, +218 ± 218, and +306 ± 205 score · min for 6, 12, and 18 g α-GOSs/d, respectively, and -5 ± 64 score · min for the control group. We observed dose-dependent effects that did not vary by α-GOS composition. The administration of 6, 12, or 18 g α-GOSs/d significantly and dose-dependently increased the change in energy intake from day 0 to day 15 during a test meal (-13 ± 19, -26 ± 22, and -32 ± 22 kcal, respectively; +6 ± 21 kcal for the control group). Reductions in energy intake during lunch and dinner were also higher in the α-GOS groups in the dose-effect study. At day 15, LPS was dose-dependently reduced without an association with α-GOS composition (0.16 ± 0.02, 0.12 ± 0.08, and 0.08 ± 0.05 EU/mL for 6, 12, and 18 g α-GOSs/d, respectively, and 0.06 ± 0.04 EU/mL for the control group) and CRP was significantly lower in the α-GOS groups than in the control group in the formulation-effect study.
  
  
  CONCLUSIONS
  Consumption of α-GOSs for 14 d dose-dependently reduced appetite, food intake, and inflammation in overweight adults with no impact of α-GOS composition. Consequently, α-GOSs appear to promote long-term weight loss and mitigate metabolic disorders.
authors.affiliation: Olygose S.A.S., Compiègne, France; fanny.morel@olygose.com.
authors.forename: Fanny B
authors.initials: FB
authors.lastname: Morel
authors.affiliation: Institute of Nutrition and Health Food, Tongji University, Shanghai, China;
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Dai
authors.affiliation: Sprim (Shanghai) Consulting Company, Shanghai, China; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada; and.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Ni
authors.affiliation: Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada; and.
authors.forename: Doneal
authors.initials: D
authors.lastname: Thomas
authors.affiliation: UMR 1280, Physiology and Nutritional Adaptation, National Institute of Agronomic Research-Université de Nantes, Institute of Digestive Diseases, Center for Research in Human Nutrition, Nantes, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Parnet
authors.affiliation: Olygose S.A.S., Compiègne, France;
authors.forename: Pascale
authors.initials: P
authors.lastname: Fança-Berthon
mesh_terms: D000293:Adolescent; D000328:Adult; D001066:Appetite / Q000187:drug effects*; D015992:Body Mass Index; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D002149:Energy Intake; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D062407:Meals; D008875:Middle Aged; D050177:Overweight / Q000188:drug therapy*; D012527:Satiation; D016896:Treatment Outcome; D014312:Trisaccharides / Q000008:administration & dosage*; D015431:Weight Loss; D055815:Young Adult
chemical_list: D014312:Trisaccharides; C072242:4'-galactooligosaccharide
keywords: alpha-galacto-oligosaccharides; appetite; fibers; food intake; inflammation