title: Influence of anesthetic variables on short-term and overall survival rates in cats undergoing renal transplantation surgery.
abstract: OBJECTIVE
  To identify factors associated with short-term (30-day) and overall survival rates in cats that underwent renal transplantation surgery (RTS).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  94 cats that underwent RTS from 1998 through 2010.
  
  
  METHODS
  Data obtained from the medical records pertinent to RTS included cat signalment; anesthetic agents, techniques, and timings; supportive treatment; perioperative physiologic findings; and surgery and warm ischemia times. Associations with short-term and overall survival rates were investigated.
  
  
  RESULTS
  Median survival time was 653 days (range, 2 to 4,580 days). Prolonged anesthesia (median, 300 minutes; range, 225 to 445 minutes) reduced overall survival rate but did not influence short-term survival rate. No associations were identified between survival rates and anesthetic agent used, amount and type of fluid administered IV, physiologic abnormalities, and blood product administration. All cats that received μ-opioid receptor antagonists at anesthetic recovery to reverse the effects of μ-opioid receptor agonists survived for at least 30 days. High Hct at the end of anesthesia was also associated with an increase in short-term survival rate. Two cats had an intraoperative hemoglobin oxygen saturation < 90%, and both died within 7 days after surgery. Cats > 12 years old had a lower overall survival rate than did younger cats.
  
  
  CONCLUSIONS
  Minimization of total anesthesia time, reversal of μ-opioid receptor agonists at the end of anesthesia, and prevention of intraoperative decreases in blood oxygen saturation and postoperative decreases in Hct appeared to help maximize postsurgical survival time in cats undergoing RTS.
authors.forename: William
authors.initials: W
authors.lastname: Snell
authors.forename: Lillian
authors.initials: L
authors.lastname: Aronson
authors.forename: Heidi
authors.initials: H
authors.lastname: Phillips
authors.forename: Lynne
authors.initials: L
authors.lastname: Beale
authors.forename: M Paula
authors.initials: MP
authors.lastname: Larenza Menzies
mesh_terms: D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D000777:Anesthetics / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D002371:Cat Diseases / Q000601:surgery*; D002415:Cats; D005260:Female; D016030:Kidney Transplantation / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies
chemical_list: D000777:Anesthetics