title: Biphenotypic human papillomavirus-associated head and neck squamous cell carcinoma: a report of two cases.
abstract: Human papillomavirus-associated oropharyngeal squamous cell carcinoma is now recognised as a subtype of head and neck cancer with distinct clinical, molecular and histological characteristics. The majority of these carcinomas are of non-keratinising squamous type but there is a growing number of histomorphologic variants of this disease. Here we describe the clinical, histomorphologic and immunophenotypic features of two cases of human papillomavirus-associated oropharyngeal squamous cell carcinoma demonstrating a clearly delineated biphasic differentiated and undifferentiated phenotype.
authors.affiliation: Head and Neck Pathology, 4th Floor Tower Wing, Guy's and St. Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK. gayani.pitiyage@nhs.net.
authors.forename: Gayani
authors.initials: G
authors.lastname: Pitiyage
authors.affiliation: Department of Clinical Oncology, Lower Ground Floor, Lambeth Wing, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, Westminster Bridge Rd, London, SE1 7EH, UK. mary.lei@gstt.nhs.uk.
authors.forename: Mary
authors.initials: M
authors.lastname: Lei
authors.affiliation: Department of Clinical Oncology, Lower Ground Floor, Lambeth Wing, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, Westminster Bridge Rd, London, SE1 7EH, UK. teresa.guerrerourbano@gstt.nhs.uk.
authors.forename: Teresa
authors.initials: T
authors.lastname: Guererro Urbano
authors.affiliation: Head and Neck Pathology, 4th Floor Tower Wing, Guy's and St. Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK. edward.odell@kcl.ac.uk.|Mucosal and Salivary Biology, King's College London Dental Institute, 4th Floor Tower Wing, Great Maze Pond, London, SE1 9RT, UK. edward.odell@kcl.ac.uk.
authors.forename: Edward
authors.initials: E
authors.lastname: Odell
authors.affiliation: Head and Neck Pathology, 4th Floor Tower Wing, Guy's and St. Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK. selvam.thavaraj@kcl.ac.uk.|Mucosal and Salivary Biology, King's College London Dental Institute, 4th Floor Tower Wing, Great Maze Pond, London, SE1 9RT, UK. selvam.thavaraj@kcl.ac.uk.
authors.forename: Selvam
authors.initials: S
authors.lastname: Thavaraj
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology*; D002454:Cell Differentiation; D059248:Chemoradiotherapy; D004279:DNA, Viral / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology*; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics*; D010641:Phenotype; D011237:Predictive Value of Tests; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D004279:DNA, Viral