title: Synthesis and degranulation-inhibiting activities of the proposed apteniols B, C, and G.
abstract: The synthesis of compounds with the structures proposed for the oxyneolignan apteniols B, C, and G is described. The diphenyl ether skeletons of the proposed apteniols were formed via Ullmann ether synthesis. In particular, the spectral data for the synthesized apteniols B, C, and G did not agree with those previously reported for the isolated compounds. Furthermore, the synthesized proposed apteniol B did not show degranulation-inhibiting activity, while the prepared proposed apteniols C and G exhibited activities considerably weaker than that of the methyl ester of proposed apteniol A.
authors.affiliation: a Faculty of Life and Environmental Sciences, Department of Life Sciences , Prefectural University of Hiroshima , Hiroshima , Japan.|b Program in Biological System Sciences , Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima , Hiroshima Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Noshita
authors.affiliation: a Faculty of Life and Environmental Sciences, Department of Life Sciences , Prefectural University of Hiroshima , Hiroshima , Japan.|b Program in Biological System Sciences , Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima , Hiroshima Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tai
authors.affiliation: b Program in Biological System Sciences , Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima , Hiroshima Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Nishikawa
authors.affiliation: b Program in Biological System Sciences , Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima , Hiroshima Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ikeda
authors.affiliation: c Faculty of Pharmaceutical Education, Department of Pharmacy , Kinki University , Osaka , Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Ouchi
authors.affiliation: d Graduate School of Engineering, Osaka Electro-Communication University , Osaka Japan.
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Hamada
authors.affiliation: d Graduate School of Engineering, Osaka Electro-Communication University , Osaka Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Saito
authors.affiliation: e Department of Bioscience and Biotechnology for Future Bioindustry , Graduate School of Agricultural Science, Tohoku University , Sendai Japan.
authors.forename: Teiko
authors.initials: T
authors.lastname: Yamada
mesh_terms: D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry*; D008738:Methyl Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000737:chemistry*
chemical_list: D017705:Lignans; D008738:Methyl Ethers; D010647:Phenyl Ethers; C000598102:apteniol A; C031538:phenyl ether
keywords: Aptenia cordifolia; Ullmann ether synthesis; apteniol, degranulation-inhibiting activity; oxyneolignan