title: Observation of a cavitation cloud in tissue using correlation between ultrafast ultrasound images.
abstract: The local application of ultrasound is known to improve drug intake by tumors. Cavitating bubbles are one of the contributing effects. A setup in which two ultrasound transducers are placed confocally is used to generate cavitation in ex vivo tissue. As the transducers emit a series of short excitation bursts, the evolution of the cavitation activity is monitored using an ultrafast ultrasound imaging system. The frame rate of the system is several thousands of images per second, which provides several tens of images between consecutive excitation bursts. Using the correlation between consecutive images for speckle tracking, a decorrelation of the imaging signal appears due to the creation, fast movement, and dissolution of the bubbles in the cavitation cloud. By analyzing this area of decorrelation, the cavitation cloud can be localized and the spatial extent of the cavitation activity characterized.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Prieur
authors.forename: Ali
authors.initials: A
authors.lastname: Zorgani
authors.forename: Stefan
authors.initials: S
authors.lastname: Catheline
authors.forename: Rémi
authors.initials: R
authors.lastname: Souchon
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mestas
authors.forename: Maxime
authors.initials: M
authors.lastname: Lafond
authors.forename: Cyril
authors.initials: C
authors.lastname: Lafon
mesh_terms: D000818:Animals; D002645:Chickens; D004867:Equipment Design; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D014159:Transducers; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods*