title: Expanding opportunities for mining bioactive chemistry from patents.
abstract: Bioactive structures published in medicinal chemistry patents typically exceed those in papers by at least twofold and may precede them by several years. The Big-Bang of open automated extraction since 2012 has contributed to over 15 million patent-derived compounds in PubChem. While mapping between chemical structures, assay results and protein targets from patent documents is challenging, these relationships can be harvested using open tools and are beginning to be curated into databases.
authors.affiliation: IUPHAR/BPS Database and Guide to PHARMACOLOGY Web Portal Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK(1). Electronic address: cdsouthan@hotmail.com.
authors.forename: Christopher
authors.initials: C
authors.lastname: Southan
mesh_terms: D002626:Chemistry, Pharmaceutical; D057225:Data Mining; D016208:Databases, Factual; D010330:Patents as Topic