title: Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Tissue Type Involving the Dura.
abstract: Primary central nervous system marginal zone B-cell lymphoma (MZBCL) is very rare, with only a few reported cases worldwide. It has an indolent disease course with high cure potential. We experienced a rare case of dural MZBCL of mucosa-associated lymphoid tissue (MALT) in a 69-year-old man who presented with headache. A magnetic resonance imaging scan of brain showed a 1.9×3.6-cm-sized extra-axial mass with a broad based dural attachment to the anterosuperior aspect of the falx cerebri, radiographically consistent with meningioma. Surgical resection yielded a MZBCL of the MALT type. Histopathology revealed a lymphoplasmacytic infiltration of the dura, and immunohistochemical study showed a B-cell phenotype with CD20, bcl-2, MUM-1, Ki-67 positive. He was treated with chemotherapy after complete surgical resection and remained free of disease at 30 months after chemotherapy. MALT lymphoma must be considered in the differential diagnosis in patients presenting radiographically with meningioma.
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Ji Hwan
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Geun Yong
authors.initials: GY
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Tae Wook
authors.initials: TW
authors.lastname: Yoon
authors.affiliation: Department of Pathology, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Yoon Jung
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Tae kyu
authors.initials: Tk
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Bong Seog
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Nam
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D004388:Dura Mater / Q000473:pathology*; D006261:Headache / Q000150:complications; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D008579:Meningioma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D009092:Mucous Membrane / Q000473:pathology
keywords: Central nervous system neoplasms; Dura mater; Marginal zone B-cell lymphoma