title: Hybrid Crosslinked Methylcellulose Hydrogel: A Predictable and Tunable Platform for Local Drug Delivery.
abstract: Design of experiment is used to develop a hybrid methylcellulose hydrogel that combines physical and chemical crosslinks, resulting in an injectable, in situ stiffening, and long-lasting material with predictable swelling and rheological properties. Chemical crosslinking is complete prior to injection, allowing for ease of use and storage. Controlled release of two relevant protein therapeutics and biocompatibility of the hydrogel are demonstrated.
authors.affiliation: Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St., Toronto, ON, M5S 3E5, Canada.|Institute for Biomaterials and Bioengineering, University of Toronto, 164 College St., Rm 407, Toronto, ON, M5S 3G9, Canada.
authors.forename: Malgosia M
authors.initials: MM
authors.lastname: Pakulska
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON, M5S 3H6, Canada.
authors.forename: Katarina
authors.initials: K
authors.lastname: Vulic
authors.affiliation: Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St., Toronto, ON, M5S 3E5, Canada.|Institute for Biomaterials and Bioengineering, University of Toronto, 164 College St., Rm 407, Toronto, ON, M5S 3G9, Canada.
authors.forename: Roger Y
authors.initials: RY
authors.lastname: Tam
authors.affiliation: Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St., Toronto, ON, M5S 3E5, Canada.|Institute for Biomaterials and Bioengineering, University of Toronto, 164 College St., Rm 407, Toronto, ON, M5S 3G9, Canada.|Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON, M5S 3H6, Canada.
authors.forename: Molly S
authors.initials: MS
authors.lastname: Shoichet
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D065546:Drug Liberation; D020100:Hydrogels / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry; D008747:Methylcellulose / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D008747:Methylcellulose
keywords: design of experiment; drug delivery; hydrogels; rheology; spinal cord injuries