title: Malaria vaccine clinical trials: what's on the horizon.
abstract: Significant progress toward a malaria vaccine, specifically for Plasmodium falciparum, has been made in the past few years with the completion of numerous clinical trials. Each trial has utilized a unique combination of antigens, delivery platforms, and adjuvants, which has provided the research community with a wealth of critical information to apply towards the development of next generation malaria vaccines. Despite the progress toward a P. falciparum vaccine, P. vivax vaccine research requires more momentum and additional investigations to identify novel vaccine candidates. In this review, recently completed and ongoing malaria vaccine clinical trials as well as vaccine candidates that are in the development pipeline are reviewed. Perspectives for future research using post-genomic mining, nonhuman primate models, and systems biology are also discussed.
authors.affiliation: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA; Malaria Host-Pathogen Interaction Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Medicine, Emory University, 69 Jesse Hill, Jr. Drive, SE, Atlanta, GA 30303, USA. Electronic address: alberto.moreno@emory.edu.
authors.forename: Alberto
authors.initials: A
authors.lastname: Moreno
authors.affiliation: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA; Malaria Host-Pathogen Interaction Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
authors.forename: Chester
authors.initials: C
authors.lastname: Joyner
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D057225:Data Mining; D004195:Disease Models, Animal; D006801:Humans; D017780:Malaria Vaccines / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology / Q000517:prevention & control*; D016780:Malaria, Vivax / Q000276:immunology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000276:immunology; D010966:Plasmodium vivax / Q000276:immunology*; D011323:Primates; D049490:Systems Biology
chemical_list: D017780:Malaria Vaccines