title: The Role of Exercise-Induced Cardiovascular Adaptation in Brain Health.
abstract: Regular aerobic exercise improves brain health; however, a potential dose-response relationship and the underling physiological mechanisms remain unclear. Existing data support the following hypotheses: 1) exercise-induced cardiovascular adaptation plays an important role in improving brain perfusion, structure, and function, and 2) a hormetic relation seems to exist between the intensity of exercise and brain health, which needs to be further elucidated.
authors.affiliation: 1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas; and 2Departments of Internal Medicine and 3Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tarumi
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000222:Adaptation, Physiological; D000368:Aged; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D003071:Cognition / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D010809:Physical Fitness / Q000502:physiology