title: Lipopeptide surfactants: Production, recovery and pore forming capacity.
abstract: Lipopeptides are microbial surface active compounds produced by a wide variety of bacteria, fungi and yeast. They are characterized by highly structural diversity and have the ability to decrease the surface and interfacial tension at the surface and interface, respectively. Surfactin, iturin and fengycin of Bacillus subtilis are among the most studied lipopeptides. This review will present the main factors encountering lipopeptides production along with the techniques developed for their extraction and purification. Moreover, we will discuss their ability to form pores and destabilize biological membrane permitting their use as antimicrobial, hemolytic and antitumor agents. These open great potential applications in biomediacal, pharmaceutic and agriculture fields.
authors.affiliation: Higher Institute of Biotechnology, Tunisia; Unit Enzymes and Bioconversion, National School of Engineers, Tunisia. Electronic address: inesmnif2011@gmail.com.
authors.forename: Mnif
authors.initials: M
authors.lastname: Inès
authors.affiliation: Higher Institute of Biotechnology, Tunisia; Unit Enzymes and Bioconversion, National School of Engineers, Tunisia.
authors.forename: Ghribi
authors.initials: G
authors.lastname: Dhouha
mesh_terms: D001412:Bacillus subtilis / Q000737:chemistry* / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D055666:Lipopeptides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013501:Surface-Active Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D055666:Lipopeptides; D013501:Surface-Active Agents
keywords: Antimicrobials; Biological activities; Biosynthesis; Extraction; Lipopeptides; Production; Purification; Surfactants