title: Cavitary pulmonary involvement of diffuse large B-cell lymphoma transformed from extra nodal marginal zone B-cell lymphoma MALT type.
abstract: We describe a case of pulmonary diffuse large B-cell lymphoma (DLBCL), which was thought to arise from extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). A 68-year-old woman presented with a 2-month history of cough and bloody sputum. The chest X-ray and computed tomography revealed a mass with cavitation in the right lower lobe. Transbronchial biopsy specimens revealed a granulomatous infiltration without malignant cells. However, diagnosis of MALT lymphoma was established from gastric biopsy specimen. Subsequently, a right lower lobectomy was performed because of hemoptysis. Examination of the resected specimen revealed a diffuse large B-cell lymphoma, which was considered to have transformed from MALT lymphoma, because both lung and stomach lesions had the chromosomal translocation t(11;18)(q21;q21) in common. In addition, there were no nodules, masses, alveolar or interstitial infiltrates in the lung fields, which are usually observed in the case of marginal zone B-cell lymphoma of bronchial mucosa-associated lymphoid tissue. These findings indicate that involvement of DLBCL have to be considered in patients with MALT lymphoma and cavitary lesion of the lung.
authors.affiliation: Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Oji-cho, Niihama, Ehime, 792-8543, Japan. hiromichi_yamane@ni.sbh.gr.jp.|4th Department of General Medicine, Kawasaki Medical School, 2-1-80 Nakasange, Okayama, 700-8505, Japan. hiromichi_yamane@ni.sbh.gr.jp.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yamane
authors.affiliation: Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ohsawa
authors.affiliation: Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Oji-cho, Niihama, Ehime, 792-8543, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shiote
authors.affiliation: Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Oji-cho, Niihama, Ehime, 792-8543, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Umemura
authors.affiliation: Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Oji-cho, Niihama, Ehime, 792-8543, Japan.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Suwaki
authors.affiliation: Division of Pathology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Oji-cho, Niihama, Ehime, 792-8543, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Shirakawa
authors.affiliation: Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Oji-cho, Niihama, Ehime, 792-8543, Japan.
authors.forename: Haruhito
authors.initials: H
authors.lastname: Kamei
authors.affiliation: 4th Department of General Medicine, Kawasaki Medical School, 2-1-80 Nakasange, Okayama, 700-8505, Japan.|Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
authors.affiliation: Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kiura
keywords: Cavitation; Diffuse large B-cell lymphoma; MALT lymphoma; Primary lung cancer