title: Hepatic sinusoidal obstruction associated with S-1 plus cisplatin chemotherapy for highly advanced gastric cancer with paraaortic lymph node metastases: report of a case.
abstract: A 56-year-old man who was diagnosed with gastric cancer with multiple paraaortic lymph node metastases was treated with S-1 plus cisplatin. The spleen gradually enlarged during the therapeutic courses. After the 6th course of therapy, the primary gastric lesion and paraaortic lymphadenopathies disappeared. He underwent a curative resection, including a distal gastrectomy with regional and paraaortic lymph node dissections. Irregularly distributed congestion of the liver was noted during the surgery. Histological examinations revealed residual cancer cells in 3 regional lymph nodes and no cancer cells in the primary site and paraaortic lymph nodes. Hepatic sinusoidal obstruction syndrome (SOS) was also confirmed histologically. This is the first report of a case with SOS after S-1 plus cisplatin therapy. S-1 plus cisplatin therapy can cause SOS, although it is a promising preoperative chemotherapy for highly advanced gastric cancer.
authors.affiliation: Department of Surgery, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan. toihirofumi@gmail.com.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Toi
authors.affiliation: Department of Gastroenterology, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Miura
authors.affiliation: Department of Surgery, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Shibasaki
authors.affiliation: Department of Gastroenterology, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Chisaka
authors.affiliation: Department of Gastroenterology, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Goto
authors.affiliation: Department of Surgery, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuda
authors.affiliation: Department of Surgery, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Surgery, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Hase
keywords: Drug liver injury; Neoadjuvant chemotherapy; Oral fluoropyrimidines; Splenomegaly; Veno-occlusive disease