title: The role of cholescintigraphy in demonstrating delayed post prandial gallbladder motility in cirrhotic patients.
abstract: OBJECTIVE
  The purpose of this study was to investigate the postprandial gallbladder motility of cirrhotic patients using cholescintigraphy by technetium-99m-ethylhydroiminodiacetic acid ((99m)Tc-EHIDA).
  
  
  METHODS
  Sixty two cirrhotic patients (Child-Pugh A: 28 patients; Child-Pugh B: 21 and Child-Pugh C: 13 patients) and 24 normal subjects were included in this study. All patients underwent cholescintigraphy. Mean gallbladder ejection fraction (GBEF) and mean ejection period (EP) were acquired by the region of interest method. In order to evaluate gallbladder contractility of cirrhotic patients, their mean GBEF and EP were compared with the same tests of normal subjects using an independent sample t test.
  
  
  RESULTS
  The mean GBEF of cirrhotic patients was lower and their mean ER was longer than that of normal subjects. The means of GBEF and EP of cirrhotic patients were different among different Child-Pugh grade groups. All these differences showed statistical significance.
  
  
  CONCLUSIONS
  This study suggests that post prandial cholescintigraphy by (99m)Tc EHIDA demonstrated slower gallbladder motility in cirrhotic patients. The ejection period of cholescintigraphy by (99m)Tc-EHIDA can be used as an index of abnormal gallbladder motility.
authors.affiliation: Nuclear Medicine Department, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xi Cheng District, Beijing 100050, PR China. 13681221974@163.com.
authors.forename: Ruirui
authors.initials: R
authors.lastname: Hao
authors.forename: Huiji
authors.initials: H
authors.lastname: Wang
authors.forename: Chunlin
authors.initials: C
authors.lastname: Li
authors.forename: Jigang
authors.initials: J
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005705:Gallbladder Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D016473:Gallbladder Emptying; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid
chemical_list: D019275:Radiopharmaceuticals; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid