title: Peptide-based hydrogen sulphide-releasing gels.
abstract: An aromatic peptide amphiphile was designed for delivery of the signaling gas H2S. The peptide self-assembled in water into nanofibers that gelled upon charge screening. The non-toxic gel slowly released H2S over 15 hours, and the presence of H2S in endothelial cells was verified using a fluorescent H2S probe.
authors.affiliation: Department of Chemistry and Macromolecules and Interfaces Institute, Virginia Tech, Blacksburg, VA 24061, USA. jbmatson@vt.edu.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Carter
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Foster
authors.forename: John B
authors.initials: JB
authors.lastname: Matson
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D015195:Drug Design; D065546:Drug Liberation; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry; D005782:Gels; D006862:Hydrogen Sulfide / Q000737:chemistry*; D051379:Mice; D057139:Nanofibers / Q000737:chemistry; D010455:Peptides / Q000737:chemistry* / Q000633:toxicity; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D005456:Fluorescent Dyes; D005782:Gels; D010455:Peptides; D014867:Water; D006862:Hydrogen Sulfide