title: [Venoarterial extracorporeal membrane oxygenation for out-of-hospital cardiac arrest. Case series of prehospital and in-hospital therapies].
abstract: Despite new concepts and strategies of basic and advanced life support, the outcome of patients with out-of-hospital cardiac arrest (OHCA) remains poor. The main reason accounting for these poor results is a low-flow phase during conventional cardiopulmonary resuscitation (CPR) with insufficient end organ perfusion. The early use of venoarterial extracorporeal membrane oxygenation (vaECMO) during CPR, i.e. extracorporeal resuscitation (ECPR) might improve OHCA survival rates as well as the neurological outcome in resuscitated patients. This article on a case series discusses the management of ECPR in three patients with OHCA. All patients suffered from a witnessed OHCA and received effective bystander CPR. After subsequent advanced cardiac life support could not achieve a return of spontaneous circulation (ROSC), vaECMO support was established as a bridge to therapy on site or after transportation to a primary or tertiary hospital. During the course of therapy two patients died and one patient was discharged after a full recovery. Early ECPR might improve the outcome in patients with prolonged cardiac arrest without ROSC. The use of ECPR should be based on the individual decision of an experienced ECPR team considering defined inclusion and exclusion criteria. As the outcome mainly depends on the duration and quality of conventional CPR, ECPR support should be requested immediately after establishing advanced life support (approximately 10-15 min).
authors.affiliation: ARDS/ECMO-Zentrum, Klinik und Poliklinik für Anästhesiologie, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Kippnich
authors.forename: C
authors.initials: C
authors.lastname: Lotz
authors.forename: M
authors.initials: M
authors.lastname: Kredel
authors.forename: C
authors.initials: C
authors.lastname: Schimmer
authors.forename: D
authors.initials: D
authors.lastname: Weismann
authors.forename: C
authors.initials: C
authors.lastname: Sommer
authors.forename: P
authors.initials: P
authors.lastname: Kranke
authors.forename: N
authors.initials: N
authors.lastname: Roewer
authors.forename: R M
authors.initials: RM
authors.lastname: Muellenbach
mesh_terms: D000293:Adolescent; D000328:Adult; D022561:Advanced Cardiac Life Support; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D004632:Emergency Medical Services / Q000379:methods* / Q000592:standards; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D058687:Out-of-Hospital Cardiac Arrest / Q000628:therapy*; D055815:Young Adult