title: Redox implications in adipose tissue (dys)function--A new look at old acquaintances.
abstract: Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to "adipocyte dysfunction", rather than fat mass accretion per se, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow.
authors.affiliation: University of Belgrade, Department of Physiology, Institute for Biological Research "Sinisa Stankovic", Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jankovic
authors.affiliation: University of Belgrade, Faculty of Biology, Center for Electron Microscopy, Belgrade, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Korac
authors.affiliation: University of Belgrade, Department of Physiology, Institute for Biological Research "Sinisa Stankovic", Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Buzadzic
authors.affiliation: University of Belgrade, Department of Physiology, Institute for Biological Research "Sinisa Stankovic", Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Otasevic
authors.affiliation: University of Belgrade, Department of Physiology, Institute for Biological Research "Sinisa Stankovic", Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Stancic
authors.affiliation: 2nd Medical Department, Molecular Cardiology, University Medical Center, Mainz, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Daiber
authors.affiliation: University of Belgrade, Department of Physiology, Institute for Biological Research "Sinisa Stankovic", Bulevar Despota Stefana 142, 11060 Belgrade, Serbia. Electronic address: koracb@ibiss.bg.ac.rs.
authors.forename: Bato
authors.initials: B
authors.lastname: Korac
mesh_terms: D017667:Adipocytes / Q000378:metabolism* / Q000473:pathology; D050156:Adipogenesis; D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004734:Energy Metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D009243:NAD / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism; D009765:Obesity / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010084:Oxidation-Reduction
chemical_list: D009243:NAD; D006861:Hydrogen Peroxide; D019255:NADPH Oxidases
keywords: Adipose tissue; Insulin resistance; Obesity; Redox