title: Association between fetal DES-exposure and psychiatric disorders in adolescence/adulthood: evidence from a French cohort of 1002 prenatally exposed children.
abstract: In utero diethylstilbestrol (DES) exposure has been demonstrated to be associated with somatic abnormalities in adult men and women. Conversely, the data are contradictory regarding the association with psychological or psychiatric disorders during adolescence and adulthood. This work was designed to determine whether prenatal exposure to DES affects brain development and whether it is associated with psychiatric disorders in male and female adolescents and young adults. HHORAGES Association, a national patient support group, has assembled a cohort of 1280 women who took DES during pregnancy. We obtained questionnaire responses from 529 families, corresponding to 1182 children divided into three groups: Group 1 (n = 180): firstborn children without DES treatment, Group 2 (n = 740): exposed children, and Group 3 (n = 262): children born after a previous pregnancy treated by DES. No psychiatric disorders were reported in Group 1. In Group 2, the incidence of disorders was drastically elevated (83.8%), and in Group 3, the incidence was still elevated (6.1%) compared with the general population. This work demonstrates that prenatal exposure to DES is associated with a high risk of psychiatric disorders in adolescence and adulthood.
authors.affiliation: a Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7628, Université Paris 6 and Association HHORAGES-France , Asnières sur Oise , France .
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Soyer-Gobillard
authors.affiliation: b Unité d'Endocrinologie-Gynécologie Pédiatrique , Service de Pédiatrie, Hôpital Arnaud de Villeneuve, CHU Montpellier and Université Montpellier , Montpellier , France , and.
authors.forename: Françoise
authors.initials: F
authors.lastname: Paris
authors.affiliation: b Unité d'Endocrinologie-Gynécologie Pédiatrique , Service de Pédiatrie, Hôpital Arnaud de Villeneuve, CHU Montpellier and Université Montpellier , Montpellier , France , and.
authors.forename: Laura
authors.initials: L
authors.lastname: Gaspari
authors.affiliation: c Département d'Urgence et Post Urgence Psychiatrique , CHU Montpellier & Université Montpellier , Montpellier , France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.affiliation: b Unité d'Endocrinologie-Gynécologie Pédiatrique , Service de Pédiatrie, Hôpital Arnaud de Villeneuve, CHU Montpellier and Université Montpellier , Montpellier , France , and.
authors.forename: Charles
authors.initials: C
authors.lastname: Sultan
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology*; D016022:Case-Control Studies; D015331:Cohort Studies; D003866:Depressive Disorder / Q000453:epidemiology*; D004054:Diethylstilbestrol / Q000627:therapeutic use*; D004968:Estrogens, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012559:Schizophrenia / Q000453:epidemiology*; D035781:Siblings; D013405:Suicide / Q000706:statistics & numerical data; D013406:Suicide, Attempted / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol
keywords: Adolescence; adulthood; prenatal DES exposure; psychiatric disorders; suicide