title: Insights into IL-23 biology: From structure to function.
abstract: Interleukin (IL-)23 is a central cytokine controlling TH17 development. Overshooting IL-23 signaling contribute to autoimmune diseases. Moreover, GWAS studies have identified several SNPs within the IL-23 receptor, which are associated with autoimmune diseases. IL-23 is a member of the IL-12-type cytokine family and consists of IL-23p19 and p40. Within the IL-12 family, IL-12 and IL-23 share the p40 cytokine subunit and the IL-12Rβ1 as one chain of the receptor complex. For signaling, IL-23 triggers heterodimerization of IL-12Rβ1 and the IL-23R. Subsequently, signal transduction pathways including JAK/STAT, MAPK and PI3K are activated. Most studies have investigated the biological relevance of IL-23 in the development of TH17 cells and autoimmunity, whereas less is known about the molecular context of IL-23 biology. Therefore, we focused on IL-23 receptor complex assembly, signal transduction and functional relevance of IL-23R SNPs in the context of IL-23-inhibitory principles.
authors.affiliation: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address: Doreen.Floss@uni-duesseldorf.de.
authors.forename: Doreen M
authors.initials: DM
authors.lastname: Floss
authors.affiliation: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Jutta
authors.initials: J
authors.lastname: Schröder
authors.affiliation: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Franke
authors.affiliation: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address: jscheller@uni-duesseldorf.de.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Scheller
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D053759:Interleukin-23 / Q000276:immunology*; D053612:Janus Kinases / Q000276:immunology; D020935:MAP Kinase Signaling System / Q000276:immunology*; D019869:Phosphatidylinositol 3-Kinases / Q000276:immunology; D018123:Receptors, Interleukin / Q000276:immunology*; D053707:Receptors, Interleukin-12 / Q000276:immunology*; D050791:STAT Transcription Factors / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology* / Q000473:pathology
chemical_list: C508438:IL12RB1 protein, human; C515500:IL23R protein, human; D053759:Interleukin-23; D018123:Receptors, Interleukin; D053707:Receptors, Interleukin-12; D050791:STAT Transcription Factors; D019869:Phosphatidylinositol 3-Kinases; D053612:Janus Kinases
keywords: IL-12Rβ1; IL-23 receptor; Interleukin 23; Signal transduction