title: Korean Medication Algorithm for Bipolar Disorder 2014: comparisons with other treatment guidelines.
abstract: Our goal was to compare the recommendations of the Korean Medication Algorithm Project for Bipolar Disorder 2014 (KMAP-BP 2014) with other recently published guidelines for the treatment of bipolar disorder. We reviewed a total of four recently published global treatment guidelines and compared each treatment recommendation of the KMAP-BP 2014 with those in other guidelines. For the initial treatment of mania, there were no significant differences across treatment guidelines. All recommended mood stabilizer (MS) or atypical antipsychotic (AAP) monotherapy or the combination of an MS with an AAP as a first-line treatment strategy for mania. However, the KMAP-BP 2014 did not prefer monotherapy with MS or AAP for dysphoric/psychotic mania. Aripiprazole, olanzapine, quetiapine, and risperidone were the first-line AAPs in nearly all of the phases of bipolar disorder across the guidelines. Most guidelines advocated newer AAPs as first-line treatment options in all phases, and lamotrigine in depressive and maintenance phases. Lithium and valproic acid were commonly used as MSs in all phases of bipolar disorder. As research evidence accumulated over time, recommendations of newer AAPs - such as asenapine, paliperidone, lurasidone, and long-acting injectable risperidone - became prominent. This comparison identifies that the treatment recommendations of the KMAP-BP 2014 are similar to those of other treatment guidelines and reflect current changes in prescription patterns for bipolar disorder based on accumulated research data. Further studies are needed to address several issues identified in our review.
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Paik Institute for Clinical Research, Inje University, Busan, Korea ; Department of Health Science and Technology, Graduate School of Inje University, Busan, Korea.
authors.forename: Jeong Goo
authors.initials: JG
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Jeju National University Hospital, Jeju, Korea.
authors.forename: Moon-Doo
authors.initials: MD
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, Korea.
authors.forename: Inki
authors.initials: I
authors.lastname: Sohn
authors.affiliation: Department of Psychiatry, Soonchunhyang University Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, Korea.
authors.forename: Se-Hoon
authors.initials: SH
authors.lastname: Shim
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hee Ryung
authors.initials: HR
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Young Sup
authors.initials: YS
authors.lastname: Woo
authors.affiliation: Department of Psychiatry, Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Korea.
authors.forename: Duk-In
authors.initials: DI
authors.lastname: Jon
authors.affiliation: Department of Psychiatry, Konkuk University Chungju Hospital, School of Medicine, Konkuk University, Chungju, Korea.
authors.forename: Jeong Seok
authors.initials: JS
authors.lastname: Seo
authors.affiliation: Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, Korea.
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Shin
authors.affiliation: Department of Psychiatry, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, Korea.
authors.forename: Kyung Joon
authors.initials: KJ
authors.lastname: Min
authors.affiliation: Department of Psychiatry, Naju National Hospital, Naju, Korea.
authors.forename: Bo-Hyun
authors.initials: BH
authors.lastname: Yoon
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Won-Myong
authors.initials: WM
authors.lastname: Bahk
keywords: KMAP-2014; bipolar disorder; guideline comparison; pharmacotherapy; treatment algorithm