title: Examination of Local Functional Homogeneity in Autism.
abstract: Increasing neuroimaging evidence suggests that autism patients exhibit abnormal brain structure and function. We used the Autism Brain Imaging Data Exchange (ABIDE) sample to analyze locally focal (~8 mm) functional connectivity of 223 autism patients and 285 normal controls from 15 international sites using a recently developed surface-based approach. We observed enhanced local connectivity in the middle frontal cortex, left precuneus, and right superior temporal sulcus, and reduced local connectivity in the right insular cortex. The local connectivity in the right middle frontal gyrus was positively correlated with the total score of the autism diagnostic observation schedule whereas the local connectivity within the right superior temporal sulcus was positively correlated with total subscores of both the communication and the stereotyped behaviors and restricted interests of the schedule. Finally, significant interactions between age and clinical diagnosis were detected in the left precuneus. These findings replicated previous observations that used a volume-based approach and suggested possible neuropathological impairments of local information processing in the frontal, temporal, parietal, and insular cortices. Novel site-variability analysis demonstrated high reproducibility of our findings across the 15 international sites. The age-disease interaction provides a potential target region for future studies to further elucidate the neurodevelopmental mechanisms of autism.
authors.affiliation: Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; University of Chinese Academy of Sciences, Shijingshan, Beijing 100049, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Hou
authors.affiliation: Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; University of Chinese Academy of Sciences, Shijingshan, Beijing 100049, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Yang
authors.affiliation: Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; Laboratory for Functional Connectome and Development, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China.
authors.forename: Xi-Nian
authors.initials: XN
authors.lastname: Zuo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001321:Autistic Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002648:Child; D063132:Connectome; D005260:Female; D006801:Humans; D008297:Male; D011859:Radiography; D015203:Reproducibility of Results