title: Clinical Characteristics and Outcomes of Pyogenic Liver Abscess in Elderly Korean Patients.
abstract: OBJECTIVE
  Incidence of pyogenic liver abscess (PLA) has been increasing worldwide, especially in the elderly population. Therefore, the aim of this study is to elucidate the clinical features and outcomes of PLA in elderly patients.
  
  
  METHODS
  A total of 602 patients diagnosed with PLA from January 2003 to January 2013 were analyzed retrospectively. The patients were divided according to two age groups;≥ 65 years (n=296) and <65 years (n=306).
  
  
  RESULTS
  The mean age was 73.59 ± 5.98 (range, 65-93) years in the elderly group. Significantly higher incidence of females (52.4% vs. 29.1%, p<0.001), hepatobiliary disease (41.2% vs. 24.8%, p<0.001), hepatobiliary procedure (29.4% vs. 13.7%, p<0.001), underlying malignancy (18.2% vs. 4.6%, p<0.001), culture positivity of resistant organism (20.6% vs. 14.4%, p=0.047), occurrence of complication (19.6% vs. 12.8%, p=0.026), and higher white blood cell (13.44 ± 6.56 vs. 12.26 ± 5.89, p=0.021), but lower rates of right lobe abscess (67.2% vs. 80.4%, p<0.001), fever (68.6% vs. 79.3%, p=0.003), and lower CRP (16.79 ± 9.67 vs. 18.80 ± 9.86, p=0.012) was observed in elderly PLA patients, compared to younger patients. Regarding complications, elderly patients had higher incidence of septic shock (8.1% vs. 2.3%, p=0.001) and cardiovascular disease (2% vs. 0%, p=0.014).
  
  
  CONCLUSIONS
  More atypical presentations and complications tend to occur in elderly PLA patients compared with younger patients. Clinicians should be aware of these age-related differences in PLA and devise management strategies accordingly.
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Wi
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Eun Ae
authors.initials: EA
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Chung Hwan
authors.initials: CH
authors.lastname: Jun
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Joo
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Sung Kyu
authors.initials: SK
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Jong Sun
authors.initials: JS
authors.lastname: Rew
authors.affiliation: Divisions of Gastroenterology and Infectious Disease, Chonnam National University College of Medicine, Gwangju, Korea.
authors.forename: Sook In
authors.initials: SI
authors.lastname: Jung
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D002648:Child; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D006801:Humans; D015994:Incidence; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D007958:Leukocyte Count; D046290:Liver Abscess, Pyogenic / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012737:Sex Factors; D012772:Shock, Septic / Q000453:epidemiology / Q000209:etiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Aged; Elderly; Prognosis; Pyogenic liver abscess