title: Effects of dietary Capsicum oleoresin on productivity and immune responses in lactating dairy cows.
abstract: This study investigated the effect of Capsicum oleoresin in granular form (CAP) on nutrient digestibility, immune responses, oxidative stress markers, blood chemistry, rumen fermentation, rumen bacterial populations, and productivity of lactating dairy cows. Eight multiparous Holstein cows, including 3 ruminally cannulated, were used in a replicated 4×4 Latin square design experiment. Experimental periods were 25 d in duration, including a 14-d adaptation and an 11-d data collection and sampling period. Treatments included control (no CAP) and daily supplementation of 250, 500, or 1,000 mg of CAP/cow. Dry matter intake was not affected by CAP (average 27.0±0.64 kg/d), but milk yield tended to quadratically increase with CAP supplementation (50.3 to 51.9±0.86 kg/d). Capsicum oleoresin quadratically increased energy-corrected milk yield, but had no effect on milk fat concentration. Rumen fermentation variables, apparent total-tract digestibility of nutrients, and N excretion in feces and urine were not affected by CAP. Blood serum β-hydroxybutyrate was quadratically increased by CAP, whereas the concentration of nonesterified fatty acids was similar among treatments. Rumen populations of Bacteroidales, Prevotella, and Roseburia decreased and Butyrivibrio increased quadratically with CAP supplementation. T cell phenotypes were not affected by treatment. Mean fluorescence intensity for phagocytic activity of neutrophils tended to be quadratically increased by CAP. Numbers of neutrophils and eosinophils and the ratio of neutrophils to lymphocytes in peripheral blood linearly increased with increasing CAP. Oxidative stress markers were not affected by CAP. Overall, in the conditions of this experiment, CAP did not affect feed intake, rumen fermentation, nutrient digestibility, T cell phenotypes, and oxidative stress markers. However, energy-corrected milk yield was quadratically increased by CAP, possibly as a result of enhanced mobilization of body fat reserves. In addition, CAP increased neutrophil activity and immune cells related to acute phase immune response.
authors.affiliation: Department of Animal Science, The Pennsylvania State University, University Park 16802.
authors.forename: J
authors.initials: J
authors.lastname: Oh
authors.affiliation: Department of Animal Science, The Pennsylvania State University, University Park 16802.
authors.forename: F
authors.initials: F
authors.lastname: Giallongo
authors.affiliation: Department of Animal Science, The Pennsylvania State University, University Park 16802.
authors.forename: T
authors.initials: T
authors.lastname: Frederick
authors.affiliation: Department of Animal Science, The Pennsylvania State University, University Park 16802.
authors.forename: J
authors.initials: J
authors.lastname: Pate
authors.affiliation: Department of Animal Science, The Pennsylvania State University, University Park 16802.
authors.forename: S
authors.initials: S
authors.lastname: Walusimbi
authors.affiliation: Department of Food Science, The Pennsylvania State University, University Park 16802.
authors.forename: R J
authors.initials: RJ
authors.lastname: Elias
authors.affiliation: Pancosma S.A., CH-1218 Geneva, Switzerland.
authors.forename: E H
authors.initials: EH
authors.lastname: Wall
authors.affiliation: InVivo Animal Nutrition & Health, Talhouët, 56250 Saint-Nolff, France.
authors.forename: D
authors.initials: D
authors.lastname: Bravo
authors.affiliation: Department of Animal Science, The Pennsylvania State University, University Park 16802. Electronic address: anh13@psu.edu.
authors.forename: A N
authors.initials: AN
authors.lastname: Hristov
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D001439:Bacteroides / Q000378:metabolism; D045856:Butyrivibrio / Q000378:metabolism; D002212:Capsicum / Q000737:chemistry*; D002417:Cattle; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D005243:Feces / Q000737:chemistry; D005260:Female; D005285:Fermentation; D000069196:Gastrointestinal Microbiome; D007774:Lactation; D008892:Milk / Q000737:chemistry; D009584:Nitrogen / Q000652:urine; D010936:Plant Extracts / Q000008:administration & dosage*; D018720:Prevotella / Q000378:metabolism; D012417:Rumen / Q000378:metabolism / Q000382:microbiology
chemical_list: D010936:Plant Extracts; C018620:oleoresins; D009584:Nitrogen; D020155:3-Hydroxybutyric Acid
keywords: capsicum oleoresin; dairy cow; immune response; milk production