title: [Efficacies of fluid resuscitation volume after combined burn-blast injury shock].
abstract: OBJECTIVE
  To explore the efficacies of resuscitation fluid volume after combined burn-blast injury versus a simple burn.
  
  
  METHODS
  A total of 24 beagle dogs were randomly assigned into 3 groups of normal volume (N), decreased volume (D) and increased volume (I). Fluid volume for group N was calculated with the Parkland formula while groups D and I decreased or increased by 20% respectively. Urinary output (UOP), hemoglobin concentration (HB), cardiac output (CO), intrathoracic blood volume (ITBV), extravascular lung water index (ELWI), oxygen delivery (DO(2)) and oxygen consumption (VO(2)) were determined before and 4, 8, 24, 48 h after injury to evaluate the sufficiency of resuscitation in each group and examine the superiority.
  
  
  RESULTS
  UOP were [(0.41 ± 0.13), (0.77 ± 0.17), (0.30 ± 0.13)] ml · kg(-1) · h(-1) at 4 h post-injury in groups N, I and D respectively. Group I was significantly higher than groups N and D (P < 0.001).It were [(0.59 ± 0.05), (0.88 ± 0.05), (0.53 ± 0.06)] ml · kg(-1) · h(-1) at 24 h post-injury in groups N, I and D respectively. Group I was significantly higher than groups N and D (P < 0.001). CO in group I was remarkably higher than those in groups N and D at 4 h and 8 h post-injury [(1.57 ± 0.19) vs (1.25 ± 0.17), (1.05 ± 0.17) L/min; (1.87 ± 0.20) vs (1.57 ± 0.24), (1.20 ± 0.19) L/min respectively] (P < 0.05); ITBV also significantly increased in group I than two other groups at 4 h and 8 h post-injury [(169 ± 16) vs (140 ± 12), (121 ± 12) ml; (161 ± 14) vs (135 ± 22), (112 ± 12) ml] (P < 0.05). VO2 in group I was significantly higher than that in group N at 24 h post-injury [(129 ± 10) vs (106 ± 12) ml · min(-1) · m(-2)] (P < 0.05). No differences were detected among 3 group in ELWI (P > 0.05).
  
  
  CONCLUSIONS
  Larger fluid volume may compensate circulatory volume loss sooner, alleviate declining cardiac output better, maintain adequate organ perfusion, promote tissue oxygenation and improve anti-hypervolemia and anti-hypoxia.
authors.affiliation: PLA Medical School, Burns and Plastic Institute, Beijing 100853, China.
authors.forename: Donghai
authors.initials: D
authors.lastname: Zhang
authors.affiliation: PLA Medical School, Burns and Plastic Institute, Beijing 100853, China; Email: cjk304@126.com.
authors.forename: Jiake
authors.initials: J
authors.lastname: Chai
authors.affiliation: PLA Medical School, Burns and Plastic Institute, Beijing 100853, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Hu
authors.affiliation: PLA Medical School, Burns and Plastic Institute, Beijing 100853, China.
authors.forename: Bailing
authors.initials: B
authors.lastname: Li
authors.affiliation: PLA Medical School, Burns and Plastic Institute, Beijing 100853, China.
authors.forename: Xulong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: PLA Medical School, Burns and Plastic Institute, Beijing 100853, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.affiliation: PLA Medical School, Burns and Plastic Institute, Beijing 100853, China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Yu
authors.affiliation: PLA Medical School, Burns and Plastic Institute, Beijing 100853, China.
authors.forename: Lingying
authors.initials: L
authors.lastname: Liu
mesh_terms: D000818:Animals; D001753:Blast Injuries; D001794:Blood Pressure; D002056:Burns; D002302:Cardiac Output; D004285:Dogs; D015633:Extravascular Lung Water; D005440:Fluid Therapy; D012151:Resuscitation; D012769:Shock