title: Effect of Leukocyte-Rich and Platelet-Rich Plasma on Healing of a Horizontal Medial Meniscus Tear in a Rabbit Model.
abstract: There are limited reports on the effect of platelet-rich plasma (PRP) on meniscus healing. The purpose of this study was to investigate the effect of leukocyte-rich PRP (L-PRP) on potential healing of the horizontal medial meniscus tears in a rabbit model. A horizontal medial meniscus tear was created in both knees of nine skeletally mature adult rabbits. Left or right knees were randomly assigned to a L-PRP group, or a control group. 0.5 mL of L-PRP from 10 mL of each rabbit's whole blood was prepared and injected into the horizontal tears in a L-PRP group. None was applied to the horizontal tears in a control group. The histological assessment of meniscus healing was performed at two, four, and six weeks after surgery. We found that there were no significant differences of quantitative histologic scoring between two groups at 2, 4, and 6 weeks after surgery (p > 0.05). This study failed to show the positive effect of single injection of L-PRP on enhancing healing of the horizontal medial meniscus tears in a rabbit model. Single injection of L-PRP into horizontal meniscus tears may not effectively enhance healing of horizontal medial meniscus tears.
authors.affiliation: Department of Orthopaedic Surgery, Korea University Anam Hospital, Korea University College of Medicine & Medical School, Seoul 136-705, Republic of Korea.
authors.forename: Kyun Ho
authors.initials: KH
authors.lastname: Shin
authors.affiliation: Korea University College of Medicine & Medical School, Seoul 136-705, Republic of Korea.
authors.forename: Haseok
authors.initials: H
authors.lastname: Lee
authors.affiliation: Korea University College of Medicine & Medical School, Seoul 136-705, Republic of Korea.
authors.forename: Seonghyun
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Orthopaedic Surgery, Korea University Ansan Hospital, Korea University College of Medicine & Medical School, Ansan 425-707, Republic of Korea.
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Ko
authors.affiliation: Department of Orthopaedic Surgery, Korea University Guro Hospital, Korea University College of Medicine & Medical School, Seoul 152-703, Republic of Korea.
authors.forename: Seung-Yup
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Orthopaedic Surgery, Korea University Ansan Hospital, Korea University College of Medicine & Medical School, Ansan 425-707, Republic of Korea.
authors.forename: Jung-Ho
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Orthopaedic Surgery, Korea University Guro Hospital, Korea University College of Medicine & Medical School, Seoul 152-703, Republic of Korea.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Bae
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007718:Knee Injuries / Q000601:surgery*; D007962:Leukocytes; D008592:Menisci, Tibial / Q000601:surgery*; D053657:Platelet-Rich Plasma; D011817:Rabbits; D000070600:Tibial Meniscus Injuries