title: Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women.
abstract: BACKGROUND
  Studies suggest that brain-derived neurotrophic factor (BDNF) exerts effects on the neuronal function of hippocampal neurons and increases hippocampal mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, which causes depressive behaviors in rat or mouse. Here we focus on the change of serum MKP-1, BDNF, testosterone (T), and estradiol (E2) levels, in order to test the hypothesis that dysregulation of MKP-1, BDNF, T, and E2 are associated with depression in perimenopausal women.
  
  
  METHODS
  Women with depression, after meeting criteria in the International Statistical Classification of Diseases and Related Health Problems, 10th Revision, for mental and behaviural disorders and the 17-item Hamilton Depression Rating Scale (HDRS), were included in the study. Psychosocial data and blood samples were obtained from the subjects in the study, including 38 perimenopausal and 32 young women with depression, 26 healthy control perimenopausal women, and 34 young women.
  
  
  RESULTS
  Serum MKP-1 levels were higher and T was lower in the women with depression compared to controls (p<0.05), and depressed perimenopausal women exhibited the highest serum MKP-1 levels and lowest T levels. Logistic regression analyses showed that MKP-1 levels were positively correlated with HDRS scores in the women, and T levels were inversely correlated with HDRS scores in the perimenopausal women (p<0.05).
  
  
  CONCLUSIONS
  This study suggests that high serum MKP-1 levels are associated with depression in women, and this association did not appear to be confounded by age. Further, the results provide evidence of association between depressive symptom severity and increasing serum MKP-1 levels in women, and decreasing T levels in perimenopausal women.
authors.affiliation: 1 First Affiliated Hospital, Xi'an Jiaotong University , Xi'an, Shaanxi, China .
authors.forename: Ling-yun
authors.initials: LY
authors.lastname: Hui
authors.affiliation: 1 First Affiliated Hospital, Xi'an Jiaotong University , Xi'an, Shaanxi, China .
authors.forename: Ya-wen
authors.initials: YW
authors.lastname: Wang
authors.affiliation: 2 Second Affiliated Hospital, Xi'an Jiaotong University , Xi'an, Shaanxi, China .
authors.forename: Fu-ling
authors.initials: FL
authors.lastname: Zhou
authors.affiliation: 1 First Affiliated Hospital, Xi'an Jiaotong University , Xi'an, Shaanxi, China .
authors.forename: Xian-cang
authors.initials: XC
authors.lastname: Ma
authors.affiliation: 1 First Affiliated Hospital, Xi'an Jiaotong University , Xi'an, Shaanxi, China .
authors.forename: Run-zhi
authors.initials: RZ
authors.lastname: Yan
authors.affiliation: 1 First Affiliated Hospital, Xi'an Jiaotong University , Xi'an, Shaanxi, China .
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: 3 Medical College of Xi'an Jiaotong University , Xi'an, Shaanxi, China .
authors.forename: Quan-li
authors.initials: QL
authors.lastname: Wang
authors.affiliation: 1 First Affiliated Hospital, Xi'an Jiaotong University , Xi'an, Shaanxi, China .
authors.forename: Xuewen
authors.initials: X
authors.lastname: Yu
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D016022:Case-Control Studies; D002681:China; D003863:Depression / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D003865:Major Depressive Disorder / Q000097:blood; D054638:Dual Specificity Phosphatase 1 / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D047648:Perimenopause / Q000097:blood / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012959:Socioeconomic Factors; D013739:Testosterone / Q000097:blood*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D013739:Testosterone; D004958:Estradiol; D054638:Dual Specificity Phosphatase 1