title: FGFR2 gene polymorphisms are associated with breast cancer risk in the Han Chinese population.
abstract: OBJECTIVE
  Breast cancer is one of the most common neoplasms among women in many developing countries including China, and is the leading cause of female cancer-related deaths worldwide.
  
  
  METHODS
  In the current study, we analyzed the relationship between 14 tag single-nucleotide polymorphisms (tSNPs) and breast cancer risk in the Han Chinese population including 185 breast cancer patients and 199 healthy women controls on the different types of breast cancer and menopausal status.
  
  
  RESULTS
  Overall, we found rs2981579 in the FGFR2 gene, and rs2380205 were associated with breast cancer susceptibility.
  
  
  CONCLUSIONS
  These findings indicate that FGFR2 was associated with breast cancer risk in the Han Chinese population, support the hypothesis that the applicability of a common susceptibility locus must be confirmed among genetically different populations.
authors.affiliation: Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710061, China ; School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xia
authors.affiliation: Department of Oncology, First Affiliated Hospital, Xi'an Medical College Xi'an 710077, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China ; Department of endocrinology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710069, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Geng
authors.affiliation: Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710061, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710061, China.
authors.forename: Chengxue
authors.initials: C
authors.lastname: Dang
authors.affiliation: Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710061, China.
authors.forename: Dongmin
authors.initials: D
authors.lastname: Chang
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, 712082, China ; Department of Genetics, Yale University School of Medicine New Haven, CT 06520 USA.
authors.forename: Longli
authors.initials: L
authors.lastname: Kang
authors.affiliation: School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China ; Department of endocrinology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
keywords: FGFR2; Single nucleotide polymorphism (SNP); breast cancer; case-control studies