title: New flavonoid and pentacyclic triterpene from Sesamum indicum leaves.
abstract: Two new and one known compounds were isolated from the methanol extract of Sesamum indicum leaves. By means of spectroscopic methods, their structures were elucidated and identified to be 3-epibartogenic acid (1), kaempferol 3-O-[2-O-(trans-p-coumaroyl)-3-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside (2) and epigallocatechin (3). Compound 1 and 3 strongly inhibited α-amylase with the IC50 values of 146.7 and 303.9 μM, respectively, in comparison with acarbose (IC50 124.0 μM).
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology , 18-Hoang Quoc Viet, Cau Giay , Hanoi , Vietnam.
authors.forename: Nguyen Tien
authors.initials: NT
authors.lastname: Dat
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology , 18-Hoang Quoc Viet, Cau Giay , Hanoi , Vietnam.
authors.forename: Nguyen Hai
authors.initials: NH
authors.lastname: Dang
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology , 18-Hoang Quoc Viet, Cau Giay , Hanoi , Vietnam.
authors.forename: Le Nguyen
authors.initials: le N
authors.lastname: Thanh
mesh_terms: D020909:Acarbose / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D031685:Sesamum / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D053978:Pentacyclic Triterpenes; D000516:alpha-Amylases; D020909:Acarbose
keywords: Pedaliaceae, 3-epibartogenic acid; Sesamum indicum; α-amylase