title: Rh-Catalyzed Construction of Quinolin-2(1H)-ones via C-H Bond Activation of Simple Anilines with CO and Alkynes.
abstract: A novel and efficient Rh-catalyzed carbonylation and annulation of simple anilines with CO and alkynes through N-H and C-H bond activation for the direct synthesis of quinolin-2(1H)-ones has been developed. Simple anilines without preactivation, broad substrate scope with hetero/polycycles, and high-value products make this protocol very practical and attractive. A key rhodacycle complex was isolated and well-characterized.
authors.affiliation: †State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road 38, Beijing 100191, China.
authors.forename: Xinyao
authors.initials: X
authors.lastname: Li
authors.affiliation: †State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road 38, Beijing 100191, China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Li
authors.affiliation: †State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road 38, Beijing 100191, China.|‡State Key Laboratory of Elemento-organic Chemistry, Nankai University, Weijin Road 94, Tianjin 300071, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000814:Aniline Compounds; D015363:Quinolones; D002244:Carbon; D002248:Carbon Monoxide; D006859:Hydrogen; D012238:Rhodium; C023650:aniline