title: pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans.
abstract: C. elegans has two functional peroxidasins (PXN), PXN-1 and PXN-2. PXN-2 is essential to consolidate the extracellular matrix during development and is suggested to interact with PXN-1 antagonistically. pxn-1 is involved in neuronal development and possibly maintenance; therefore, we investigated the relationship between pxn-1 and pxn-2 in neuronal development and in aging. During neuronal development, defects caused by pxn-1 overexpression were suppressed by overexpression of both pxn-1 and pxn-2. In neuronal aging process, pxn-1 mutants showed less age-related neuronal defects, such as neuronal outgrowth, neuronal wavy processes, and enhanced short-term memory performance. In addition, pxn-2 overexpressing animals retained an intact neuronal morphology when compared with age-matched controls. Consistent with these results, overexpression of both pxn-1 and pxn-2 restored the severe neuronal defects present with pxn-1 overexpression. These results implied that there is a negative relationship between pxn-1 and pxn-2 via pxn-1 regulating pxn-2. Therefore, pxn-1 may function in neuronal development and age-related neuronal maintenance through pxn-2.
authors.affiliation: Department of Biology Education, College of Education, Chosun University, Gwangju 501-759, Korea.
authors.forename: Injeong
authors.initials: I
authors.lastname: Cho
authors.affiliation: Department of Biology Education, College of Education, Chosun University, Gwangju 501-759, Korea.
authors.forename: Gyu Jin
authors.initials: GJ
authors.lastname: Hwang
authors.affiliation: Department of Biology Education, College of Education, Chosun University, Gwangju 501-759, Korea.
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Cho
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D023421:Models, Animal; D055495:Neurogenesis; D054464:Peroxiredoxins / Q000378:metabolism*; D000097423:Peroxidasin
chemical_list: D029742:Caenorhabditis elegans Proteins; D054464:Peroxiredoxins; C000602044:PXN-1 protein, C elegans; D000097423:Peroxidasin; C553208:PXN-2 protein, C elegans
keywords: C. elegans; antagonistic relationship; neuronal aging; neuronal development; pxn-1; pxn-2