title: Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery.
abstract: Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo. The results indicated that GE11 conjugated phospholipid micelles should have potential applications in cancer therapy.
authors.affiliation: a State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Fan
authors.affiliation: a State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Liang
authors.affiliation: a State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Danbo
authors.initials: D
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Pan
authors.affiliation: a State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Zonghai
authors.initials: Z
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Hongyang
authors.initials: H
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Bizhi
authors.initials: B
authors.lastname: Shi
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008823:Micelles; D010455:Peptides / Q000378:metabolism; D010743:Phospholipids / Q000008:administration & dosage*
chemical_list: C572557:GE11 peptide; D008823:Micelles; D010455:Peptides; D010743:Phospholipids; D004317:Doxorubicin; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: Doxorubicin; GE11; epidermal growth factor receptor; micelles; targeted drug delivery