title: Non-alkaloids extract from Stemona sessilifolia enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells.
abstract: One of the major impediments to the successful treatment of cancer is the development of resistant cancer cells, which could cause multidrug resistance (MDR), and overexpression of ABCB1/P-glycoprotein (P-gp) is one of the most common causes of MDR in cancer cells. Recently, natural products or plant-derived chemicals have been investigated more and more widely as potential multidrug-resistant (MDR) reversing agents. The current study demonstrated for the first time that non-alkaloids extract from Stemona sessilifolia significantly reversed the resistance of chemotherapeutic agents, adriamycin, paclitaxel and vincristine to MCF-7/ADR cells compared with MCF-7/S cells in a dose-dependent manner. The results obtained from these studies indicated that the non-alkaloids extract from S. sessilifolia plays an important role in reversing MDR of cancer as a P-gp modulator in vitro and may be effective in the treatment of multidrug-resistant cancers.
authors.affiliation: a Department of Pharmacy , General Hospital of Shenyang Military Area Command , Shenyang 110840 , China.|b Department of Life Science and Biochemistry , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Lu
authors.initials: L
authors.lastname: Han
authors.affiliation: b Department of Life Science and Biochemistry , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Yang-Mei
authors.initials: YM
authors.lastname: Ma
authors.affiliation: b Department of Life Science and Biochemistry , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Li
authors.initials: L
authors.lastname: An
authors.affiliation: b Department of Life Science and Biochemistry , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: a Department of Pharmacy , General Hospital of Shenyang Military Area Command , Shenyang 110840 , China.
authors.forename: Chang-Li
authors.initials: CL
authors.lastname: Wang
authors.affiliation: a Department of Pharmacy , General Hospital of Shenyang Military Area Command , Shenyang 110840 , China.
authors.forename: Qing-Chun
authors.initials: QC
authors.lastname: Zhao
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans; D061986:MCF-7 Cells; D017239:Paclitaxel / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D041901:Stemonaceae / Q000737:chemistry*
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D000970:Antineoplastic Agents; D010936:Plant Extracts; D004317:Doxorubicin; D017239:Paclitaxel
keywords: MCF-7/ADR cells; P-gp; Stemona sessilifolia; cancer; multidrug resistance; non-alkaloids extract