title: Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins.
abstract: Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.
authors.affiliation: School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. 2140220106@email.szu.edu.cn.
authors.forename: Meiqi
authors.initials: M
authors.lastname: Zeng
authors.affiliation: School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. 83484191@qq.com.
authors.forename: Manyin
authors.initials: M
authors.lastname: Zheng
authors.affiliation: School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. delu@szu.edu.cn.
authors.forename: Desheng
authors.initials: D
authors.lastname: Lu
authors.affiliation: School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. yxywj@szu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. jiangwq@sysucc.org.cn.|School of Medicine, Shenzhen University, Shenzhen, 518060, Guangdong, People's Republic of China. jiangwq@sysucc.org.cn.|State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, People's Republic of China. jiangwq@sysucc.org.cn.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, Guangdong, People's Republic of China. jiangwq@sysucc.org.cn.
authors.forename: Wenqi
authors.initials: W
authors.lastname: Jiang
authors.affiliation: School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. shaou@szu.edu.cn.
authors.forename: Ou
authors.initials: O
authors.lastname: Sha
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D017209:Apoptosis; D004721:Endoplasmic Reticulum; D006801:Humans; D008928:Mitochondria; D010940:Plant Proteins; D053218:Receptors, Death Domain; D054788:Ribosome Inactivating Proteins; D012270:Ribosomes
chemical_list: D000970:Antineoplastic Agents; D010940:Plant Proteins; D053218:Receptors, Death Domain; D054788:Ribosome Inactivating Proteins