title: Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms.
abstract: The aim of the study was to determine the serum levels of soluble adhesion molecules and hs-CRP in elderly diabetics with mild cognitive impairment (MCI) alone or with depressive symptoms. Methods. 219 diabetics elders were screened for psychiatric disorders and divided: group 1, MCI without depressive mood; group 2, MCI with depressive mood; group 3, controls. Data of biochemical parameters and biomarkers were collected. Results. In groups 1 and 2 levels of all biomarkers were significantly higher as compared to controls. The highest level of hs-CRP and sICAM-1 was detected in group 2. SVCAM-1 and sE-selectin levels were also the highest in group 2; however they did not significantly differ as compared to group 1. MoCA score was negatively correlated with all biomarkers in group 1. The logistic regression model showed that variables which increased the likelihood of having depressive syndrome in MCI patients were older age, stroke, neuropathy, increased number of comorbidities, and higher sICAM-1 level. Conclusions. We first demonstrated that elderly diabetic patients with MCI, particularly those with depressive mood have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation. Coexisting depressive syndrome in patients with MCI through common inflammatory pathways may result in augmentation of psychiatric disorders.
authors.affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Gorska-Ciebiada
authors.affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Saryusz-Wolska
authors.affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Borkowska
authors.affiliation: Department of General and Oncological Pneumology, Medical University of Lodz, 22 Kopcinskiego Street, 90-153 Lodz, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Ciebiada
authors.affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Loba
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D060825:Cognitive Dysfunction / Q000097:blood / Q000150:complications / Q000453:epidemiology; D015331:Cohort Studies; D003863:Depression / Q000097:blood / Q000150:complications / Q000453:epidemiology; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules