title: Cobalt(II)-Catalyzed C(sp2)-H Alkynylation/Annulation with Terminal Alkynes: Selective Access to 3-Methyleneisoindolin-1-one.
abstract: A highly efficient cobalt(II)-catalyzed alkynylation/annulation of terminal alkynes assisted by an N,O-bidentate directing group is described. This protocol is characterized by wide substrate scope utilizing cheap cobalt catalysts, and offers a new approach to 3-methyleneisoindolin-1-one, which can be converted into an oxadiazine salt in one step. Moreover, the directing group could be removed in three steps.
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Kexue avenue 100, Zhengzhou 450001 (P. R. China).
authors.forename: Lin-Bao
authors.initials: LB
authors.lastname: Zhang
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Kexue avenue 100, Zhengzhou 450001 (P. R. China).
authors.forename: Xin-Qi
authors.initials: XQ
authors.lastname: Hao
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Kexue avenue 100, Zhengzhou 450001 (P. R. China).
authors.forename: Zhan-Jiang
authors.initials: ZJ
authors.lastname: Liu
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Kexue avenue 100, Zhengzhou 450001 (P. R. China).
authors.forename: Xin-Xiang
authors.initials: XX
authors.lastname: Zheng
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Kexue avenue 100, Zhengzhou 450001 (P. R. China).
authors.forename: Shou-Kun
authors.initials: SK
authors.lastname: Zhang
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Kexue avenue 100, Zhengzhou 450001 (P. R. China). niujunlong@zzu.edu.cn.
authors.forename: Jun-Long
authors.initials: JL
authors.lastname: Niu
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Kexue avenue 100, Zhengzhou 450001 (P. R. China). mpsong@zzu.edu.cn.
authors.forename: Mao-Ping
authors.initials: MP
authors.lastname: Song
keywords: CH activation; annulations; cobalt; ligand design; nitrogen oxides