title: Pneumococcal Meningitis Vaccine Breakthroughs and Failures After Routine 7-Valent and 13-Valent Pneumococcal Conjugate Vaccination in Children in France.
abstract: We collected cases of pneumococcal meningitis vaccine breakthrough (VBT) and vaccine failure (VF) from 2003 to 2013 after the implementation of pneumococcal conjugate vaccines (PCVs) in France. VBT accounted for 3.2% of the cases (PCV7 era: 24 of 943, PCV13 era: 15 of 290) and VF 0.6% (PCV7 era: 6 of 943, PCV13 era: 2 of 290). VBT and VF are rare and occur in most cases in children younger than 2 years. The serotype 19F was the most frequent cause even after the introduction of PCV13.
authors.affiliation: From the *Groupe de Pathologie Infectieuse Pédiatrique (GPIP) de la Société Française de Pédiatrie (SFP), Paris, France; †Service de pédiatrie générale, Centre Hospitalier Intercommunal de Créteil, Créteil, France; ‡Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV), Saint-Maur-des-Fossés, France; §Centre de Recherche Clinique (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France; ¶Centre National de Référence des pneumocoques, hôpital européen Georges-Pompidou, Paris, France; ‖Centre d'étude des déficits immunitaires (CEDI), hôpital Necker-Enfants Malades, Paris, France; **Laboratoire de Génétique Humaine des Maladies Infectieuses, INSERM UMR 1163-Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, Paris, France; and ††Service de néonatologie, unité court séjour petits nourrissons, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Godot
authors.forename: Corinne
authors.initials: C
authors.lastname: Levy
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Varon
authors.forename: Capucine
authors.initials: C
authors.lastname: Picard
authors.forename: Fouad
authors.initials: F
authors.lastname: Madhi
authors.forename: Robert
authors.initials: R
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D012189:Retrospective Studies; D017211:Treatment Failure; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate