title: Anticancer Organometallic Osmium(II)-p-cymene Complexes.
abstract: Osmium compounds are attracting increasing attention as potential anticancer drugs. In this context, a series of bifunctional organometallic osmium(II)-p-cymene complexes functionalized with alkyl or perfluoroalkyl groups were prepared and screened for their antiproliferative activity. Three compounds from the series display selectivity toward cancer cells, with moderate cytotoxicity observed against human ovarian carcinoma (A2780) cells, whereas no cytotoxicity was observed on non-cancerous human embryonic kidney (HEK-293) cells and human endothelial (ECRF24) cells. Two of these three cancer-cell-selective compounds induce cell death largely via apoptosis and were also found to disrupt vascularization in the chicken embryo chorioallantoic membrane (CAM) model. Based on these promising properties, these compounds have potential clinical applications.
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).
authors.forename: Emilia
authors.initials: E
authors.lastname: Păunescu
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).|Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, 1081 HV Amsterdam (The Netherlands).
authors.forename: Patrycja
authors.initials: P
authors.lastname: Nowak-Sliwinska
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Clavel
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).
authors.forename: Rosario
authors.initials: R
authors.lastname: Scopelliti
authors.affiliation: Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, 1081 HV Amsterdam (The Netherlands).
authors.forename: Arjan W
authors.initials: AW
authors.lastname: Griffioen
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland). paul.dyson@epfl.ch.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D018360:Crystallography, X-Ray; D000081007:Cymenes; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D042783:Endothelial Cells / Q000187:drug effects; D057809:HEK293 Cells / Q000187:drug effects; D006801:Humans; D039821:Monoterpenes / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D017892:Osmium Compounds / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000081007:Cymenes; D039821:Monoterpenes; D009942:Organometallic Compounds; D017892:Osmium Compounds; C007210:4-cymene; D012428:Ruthenium
keywords: antitumor agents; bioorganometallic chemistry; chorioallantoic membrane model; osmium complexes