title: Combination therapy in pulmonary arterial hypertension: is this the new standard of care?
abstract: Pulmonary arterial hypertension (PAH) is a rare, progressive, and potentially fatal cardiopulmonary syndrome that imposes a significant burden on patients in terms of morbidity and mortality, and on managed care organizations in terms of resource utilization. The majority of PAH-approved therapies are high-touch, high-management, high-cost treatments dispensed through specialty pharmacies. Current treatment guidelines recommend combination therapy for patients who show inadequate clinical response or who deteriorate on monotherapy. Combination therapies target 2, or sometimes 3, distinct PAH-associated signaling pathways: the endothelin, prostacyclin, and nitric oxide pathways. Registry data suggest that combination therapy is utilized in more than half of patients with PAH in the United States. Evidence supporting the use of combination therapy is provided through clinical trials, retrospective research, registry data, and expert guidelines. Managed care decision makers are charged with making population-based decisions on resource allocation. These decision makers must always consider cost, but must also be aware that clinical evidence suggests that early treatment with combination therapy can significantly reduce disease burden, may reduce hospitalizations, and should be considered when making coverage decisions.
authors.affiliation: Medstar Heart Institute, 110 Irving St NW, Washington, DC 20010. E-mail: george.ruiz@medstar.net.
authors.forename: George
authors.initials: G
authors.lastname: Ruiz
authors.forename: Gary M
authors.initials: GM
authors.lastname: Besinque
authors.forename: Cassandra A
authors.initials: CA
authors.lastname: Lickert
authors.forename: Susan
authors.initials: S
authors.lastname: Raspa
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D059039:Standard of Care
chemical_list: D000959:Antihypertensive Agents