title: The prognostic performance of the complement system in septic patients in emergency department: a cohort study.
abstract: OBJECTIVE
  To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors.
  
  
  METHODS
  The prognostic value of complement components was compared with mortality in emergency department sepsis (MEDS) score.
  
  
  RESULTS
  Median complement 3, MAC and mannose-binding lectin increased directly with the sepsis, severe sepsis and septic shock groups, and were significantly higher in nonsurvivors than in survivors.
  
  
  CONCLUSIONS
  MEDS and MAC independently predicted in-hospital mortality. The prognostic performance of MAC was superior to MEDS as analyzed by receiver operating characteristic curve and area under the curve.
authors.affiliation: Emergency Department, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang District, Beijing 100020, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Emergency Department, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang District, Beijing 100020, China.
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Chen
authors.affiliation: Emergency Department, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang District, Beijing 100020, China.
authors.forename: Chun-Sheng
authors.initials: CS
authors.lastname: Li
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000032:analysis; D015331:Cohort Studies; D015938:Complement Membrane Attack Complex / Q000032:analysis*; D004636:Emergency Service, Hospital; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000032:analysis; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D012372:ROC Curve; D018805:Sepsis / Q000175:diagnosis* / Q000401:mortality
chemical_list: D015415:Biomarkers; D015938:Complement Membrane Attack Complex; D037601:Mannose-Binding Lectin
keywords: MEDS; complement; mortality; sepsis