title: Metabolomics in the pharmaceutical industry.
abstract: Metabolomics has roots in the pharmaceutical industry that go back nearly three decades. Initially focused on applications in toxicology and disease pathology, more recent academic and commercial efforts have helped advance metabolomics as a tool to reveal the molecular basis of biological processes and pharmacological responses to drugs. This article will discuss areas where metabolomic technologies and applications are poised to have the greatest impact in the discovery and development of pharmaceuticals.
authors.affiliation: Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Co., Princeton, NJ, USA. Electronic address: michael.reily@bms.com.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Reily
authors.affiliation: Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Co., Princeton, NJ, USA.
authors.forename: Adrienne A
authors.initials: AA
authors.lastname: Tymiak
mesh_terms: D055808:Drug Discovery; D004345:Drug Industry; D006801:Humans; D055432:Metabolomics