title: Structural correlates of spoken language abilities: A surface-based region-of interest morphometry study.
abstract: Brain structure can predict many aspects of human behavior, though the extent of this relationship in healthy adults, particularly for language-related skills, remains largely unknown. The objective of the present study was to explore this relation using magnetic resonance imaging (MRI) on a group of 21 healthy young adults who completed two language tasks: (1) semantic fluency and (2) sentence generation. For each region of interest, cortical thickness, surface area, and volume were calculated. The results show that verbal fluency scores correlated mainly with measures of brain morphology in the left inferior frontal cortex and bilateral insula. Sentence generation scores correlated with structure of the left inferior parietal and right inferior frontal regions. These results reveal that the anatomy of several structures in frontal and parietal lobes is associated with spoken language performance. The presence of both negative and positive correlations highlights the complex relation between brain and language.
authors.affiliation: Centre de Recherche de l'Institut Universitaire en santé mentale de Québec (CRIUSMQ), Québec City, QC, Canada; Université Laval, Faculté de médecine, Québec City, QC, Canada.
authors.forename: Didier
authors.initials: D
authors.lastname: Roehrich-Gascon
authors.affiliation: University of California, Irvine, USA.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Small
authors.affiliation: Centre de Recherche de l'Institut Universitaire en santé mentale de Québec (CRIUSMQ), Québec City, QC, Canada; Université Laval, Faculté de médecine, Québec City, QC, Canada. Electronic address: Pascale.Tremblay@fmed.ulaval.ca.
authors.forename: Pascale
authors.initials: P
authors.lastname: Tremblay
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology; D012660:Semantics; D013060:Speech / Q000502:physiology*; D055815:Young Adult
keywords: Cerebral cortex; Gray matter; Language; Magnetic resonance imaging; Neuroanatomy; Sentence generation; Speech production; Surface-based morphometry; Verbal fluency