title: Candida albicans Biofilm Development and Its Genetic Control.
abstract: The fungus Candida albicans is a major source of device-associated infection because of its capacity for biofilm formation. It is part of the natural mucosal flora and thus has access to available niches that can lead to infection. In this chapter we discuss the major properties of C. albicans biofilms and the insight that has been gleaned from their genetic determinants. Our specific areas of focus include biofilm structure and development, cell morphology and biofilm formation, biofilm-associated gene expression, the cell surface and adherence, the extracellular matrix, biofilm metabolism, and biofilm drug resistance.
authors.affiliation: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
authors.forename: Jigar V
authors.initials: JV
authors.lastname: Desai
authors.affiliation: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Mitchell
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D002176:Candida albicans / Q000187:drug effects / Q000235:genetics*; D002448:Cell Adhesion / Q000235:genetics*; D002473:Cell Wall / Q000502:physiology*; D025141:Drug Resistance, Fungal; D004866:Equipment Contamination; D005109:Extracellular Matrix / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D006801:Humans
chemical_list: D000935:Antifungal Agents