title: A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking.
abstract: We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.
authors.affiliation: 1] Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University, Beijing 100191, China. [2] National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Yi-xiao
authors.initials: YX
authors.lastname: Luo
authors.affiliation: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Yan-xue
authors.initials: YX
authors.lastname: Xue
authors.affiliation: 1] Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University, Beijing 100191, China. [2] National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Liu
authors.affiliation: Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Hai-shui
authors.initials: HS
authors.lastname: Shi
authors.affiliation: 1] Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University, Beijing 100191, China. [2] National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Min
authors.initials: M
authors.lastname: Jian
authors.affiliation: 1] Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University, Beijing 100191, China. [2] National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Wei-li
authors.initials: WL
authors.lastname: Zhu
authors.affiliation: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Bao
authors.affiliation: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.affiliation: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Zeng-bo
authors.initials: ZB
authors.lastname: Ding
authors.affiliation: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Hao-wei
authors.initials: HW
authors.lastname: Shen
authors.affiliation: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Shi
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
authors.forename: Yavin
authors.initials: Y
authors.lastname: Shaham
authors.affiliation: 1] Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University, Beijing 100191, China. [2] National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China. [3] Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
mesh_terms: D000818:Animals; D066272:Basolateral Nuclear Complex / Q000378:metabolism*; D001522:Behavior, Animal / Q000502:physiology*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D003042:Cocaine / Q000008:administration & dosage*; D003213:Conditioning, Psychological / Q000502:physiology; D003463:Cues; D058999:Drug-Seeking Behavior / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology*; D007266:Inhibition, Psychological; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008774:Methylphenidate / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism*; D012008:Recurrence; D012646:Self Administration
chemical_list: D000697:Central Nervous System Stimulants; D018091:Receptors, AMPA; D008774:Methylphenidate; D003042:Cocaine