title: Association between the IL1B -31C > T polymorphism and Helicobacter pylori infection in Asian and Latin American population: A meta-analysis.
abstract: BACKGROUND
  Host genetic factors that control the production of cytokines, including interleukin-1β (IL-1β), possibly affect susceptibility to many Helicobacter pylori-related diseases. There is a complex interplay between H. pylori infection, the subsequent production of certain cytokines, and H. pylori-related diseases. We conducted a meta-analysis to clarify the association between the IL1B -31C > T polymorphism and H. pylori infection, and possible subsequent pathogenic mechanisms.
  
  
  METHODS
  Published literature contained within PubMed, Embase, and the Cochrane Library was used in our meta-analysis. Data were analyzed with the STATA 13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (95% CI). Egger's regression test, Begg's rank correlation test, and Begg's funnel plot were used to test publication bias.
  
  
  RESULTS
  A total of 12 case-control studies comprising 5827 subjects (3335 cases and 2492 controls) were available for our meta-analysis. The IL1B -31C > T polymorphism was associated with an increased risk of H. pylori infection in Asian and Latin American population (TT + CT vs. CC, OR = 1.29, 95% CI = 1.14-1.46; TT vs. CT + CC, OR = 1.23, 95% CI = 1.09-1.39; TT vs. CC, OR = 1.43, 95% CI = 1.22-1.67; T allele vs. C allele, OR = 1.19, 95% CI = 1.10-1.29). A significant association was also found for all genetic models in various subgroups (cancer and no-cancer, hospital- and population-based).
  
  
  CONCLUSIONS
  Our meta-analysis demonstrated that IL1B -31C > T polymorphism might increase H. pylori infection risk in Asian and Latin American population. Further studies with different ethnicities and larger sample size are required to validate this result.
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Second Hospital of Gansu Province, Lanzhou 730000, China.
authors.forename: Fuhua
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jing
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. Electronic address: hanj@lzu.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Gastroenterology, Second Hospital of Gansu Province, Lanzhou 730000, China. Electronic address: zjh51272@163.com.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zhang
mesh_terms: D001208:Asia; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000235:genetics* / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D007843:Latin America; D020641:Polymorphism, Single Nucleotide
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta
keywords: Helicobacter pylori; Interleukin-1β; Meta-analysis; Polymorphism