title: Cough hypersensitivity as a neuro-immune interaction.
abstract: Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to 'cough hypersensitivity syndrome' suggests that chronic cough arises from hypersensitivity of the airway sensory nerves. As cough reflex is determined by interaction of the nervous system with immune system, persistent dysregulation of one or both of these systems may lead to chronic cough hypersensitivity. Here we review the current evidence for the neuro-immune interactions that underlie cough hypersensitivity and discuss future therapeutic strategies.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Chongno-gu, Seoul, 110-744 South Korea ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea.
authors.forename: Woo-Jung
authors.identifier: 0000-0002-4630-9922
authors.initials: WJ
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Chongno-gu, Seoul, 110-744 South Korea ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do South Korea.
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Chang
keywords: Cough; Hypersensitivity; Immune; Interaction; Neuron