title: Substrate Directed C-H Activation for the Synthesis of Benzo[c]cinnolines through a Sequential C-C and C-N Bond Formation.
abstract: A wide range of benzo[c]cinnolines are prepared through a sequential C-C and C-N bond formation by means of an oxidative C-H functionalization. The reaction proceeds via the C-arylation of 1-arylhydrazine-1,2-dicarboxylate with aryl iodide using Pd(OAc)2/AgOAc followed by an oxidative N-arylation in the presence of PhI/oxone in trifluoroacetic acid. It is entirely a new strategy to generate the benzo[c]cinnoline libraries with a diverse substitution pattern.
authors.affiliation: †Natural Product Chemistry, ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: B V Subba
authors.initials: BV
authors.lastname: Reddy
authors.affiliation: †Natural Product Chemistry, ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: C Ravikumar
authors.initials: CR
authors.lastname: Reddy
authors.affiliation: †Natural Product Chemistry, ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: M Rajashekhar
authors.initials: MR
authors.lastname: Reddy
authors.affiliation: †Natural Product Chemistry, ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Suresh
authors.initials: S
authors.lastname: Yarlagadda
authors.affiliation: †Natural Product Chemistry, ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: B
authors.initials: B
authors.lastname: Sridhar