title: Influence of thyroid dysfunction on serum levels of angiopoietin-like protein 6.
abstract: Angiopoietin-like protein 6 (ANGPTL6) is a novel metabolic regulator that modulates energy expenditure as well as glucose and lipid metabolism. Thyroid hormone can induce metabolic changes that are similar to those induced by ANGPTL6. Herein, we investigated whether circulating ANGPTL6 levels change according to thyroid hormone status in humans. We measured the serum levels of ANGPTL6 and metabolic parameters in 150 drug-naïve subjects with overt hyperthyroid, subclinical hyperthyroid, euthyroid, subclinical hypothyroid, or overt hypothyroid status (n=30 in each group). Serum ANGPTL6 levels were significantly higher in patients with overt hypothyroidism than in the other subjects. Women had significantly higher serum levels of ANGPTL6 than men. ANGPTL6 levels correlated positively with thyroid stimulating hormone (TSH), total cholesterol, aspartate aminotransferase, and alanine aminotransferase (ALT) and negatively with serum free thyroxine (T4) level. Multiple stepwise linear regression analysis revealed that sex, TSH, free T4, and ALT were independent predictors of serum ANGPTL6 levels. In summary, serum ANGPTL6 levels increased in patients with a hypothyroid status, and both TSH and free T4 levels are associated with ANGPLT6 levels, suggesting a possible association between thyroid function and ANGPTL6 levels. Whether the upregulated ANGPTL6 level in the hypothyroid status is primarily owing to a direct association or a compensatory mechanism remains to be determined.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul; Department of Internal Medicine, National Medical Center, Seoul.
authors.forename: Jung Ah
authors.initials: JA
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Eulji Medical Center, Seoul.
authors.forename: Hyo Jeong
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul; Department of Internal Medicine, Chung-Ang University Hospital, Seoul.
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Ahn
authors.affiliation: Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: Kyoung Un
authors.initials: KU
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul.
authors.forename: Ka Hee
authors.initials: KH
authors.lastname: Yi
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul.
authors.forename: Do Joon
authors.initials: DJ
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul.
authors.forename: Hak Chul
authors.initials: HC
authors.lastname: Jang
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul. Electronic address: yjparkmd@snu.ac.kr.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Park
mesh_terms: D000328:Adult; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000097:blood*; D058070:Asymptomatic Diseases; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000453:epidemiology; D007037:Hypothyroidism / Q000097:blood / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013959:Thyroid Diseases / Q000097:blood* / Q000453:epidemiology; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: C477601:ANGPTL6 protein, human; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D013972:Thyrotropin; D013974:Thyroxine
keywords: Adipokines; Angiopoietin-like 6 protein; Human; Thyroid