title: Simultaneous PET/MRI in stroke: a case series.
abstract: Prospective studies on magnetic resonance imaging (MRI)-guided systemic thrombolysis >4.5 hours after stroke onset did not reach their primary end points. It was discussed and observed in post hoc data re-assessment that this was partly because of limited MRI accuracy to measure critical hypoperfusion. We report the first cases of simultaneous [(15)O]H2O-positron emission tomography (PET)/MRI in stroke patients and an ovine model. Discrepancies between simultaneously obtained PET and MRI readouts were observed that might explain the above current limitations of stroke MRI. By offering highly complementary information, [(15)O]H2O-PET/MRI might help to identify critically hypoperfused tissue resulting in an improved patient stratification in thrombolysis trials.
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Werner
authors.affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Saur
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Vilia
authors.initials: V
authors.lastname: Zeisig
authors.affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ettrich
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Marianne
authors.initials: M
authors.lastname: Patt
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Sattler
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Thies
authors.initials: T
authors.lastname: Jochimsen
authors.affiliation: Department of Neuroradiology, University of Leipzig, Leipzig, Germany.
authors.forename: Donald
authors.initials: D
authors.lastname: Lobsien
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Philipp M
authors.initials: PM
authors.lastname: Meyer
authors.affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.|Translational Centre for Regenerative Medicine, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.
authors.forename: Florian Then
authors.initials: FT
authors.lastname: Bergh
authors.affiliation: Translational Centre for Regenerative Medicine, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.|Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Dreyer
authors.affiliation: Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.|Massachusetts General Hospital and Harvard Medical School, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts, USA.
authors.forename: Johannes
authors.initials: J
authors.lastname: Boltze
authors.affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.
authors.forename: Joseph
authors.initials: J
authors.lastname: Classen
authors.affiliation: Department of Neuroradiology, University of Leipzig, Leipzig, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Fritzsch
authors.affiliation: Department of Neuroradiology, University of Leipzig, Leipzig, Germany.
authors.forename: Karl-Titus
authors.initials: KT
authors.lastname: Hoffmann
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Osama
authors.initials: O
authors.lastname: Sabri
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Henryk
authors.initials: H
authors.lastname: Barthel
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D049268:Positron-Emission Tomography; D011859:Radiography; D020521:Stroke / Q000000981:diagnostic imaging*