title: Protective effect of telmisartan on rats with renal failure and its mechanism.
abstract: OBJECTIVE
  To study the protective effect of telmisartan on rats with renal failure and its mechanism.
  
  
  METHODS
  60 Wistar rats were chosen as study objective, and were divided into 4 groups randomly: 15 in group A (sham operation group), 15 in group B (model group), 15 in group C (telmisartan group) and 15 in group D (telmisartan + GW9962 group). The difference of survival rate, blood-urine biochemical indexes, renal pathological change, and the expression level of PPARγ and nNOS were compared.
  
  
  RESULTS
  After 12 weeks, the survival rate of group A was 93.33% (14/15), that of group B was 46.67% (7/15), that of group C was 86.67% (13/15), that of group D was 60.00% (9/15), and the difference among 4 groups had statistical significance (P < 0.05). After 1 week, the difference of Scr, that of BUN and that of 24 h protein urine among 4 groups was not statistical significant (P > 0.05); after 3 weeks, 6 weeks and 12 weeks, these difference was statistical significant (P < 0.05). The difference of blood-urine biochemical indexes, that of renal pathological change, and that of the expression level of PPARγ and nNOS was statistical significant (P < 0.05).
  
  
  CONCLUSIONS
  Telmisartan has protective effect on renal failure caused by 5/6 nephrectomy, which might be relative to the expression level of PPARγ and nNOS.
authors.affiliation: Department of Nephrology, Linyi People's Hospital, Linyi 276003, Shandong, China. Electronic address: Wangzk1996@aliyun.com.
authors.forename: Zhi-Kui
authors.initials: ZK
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Linyi People's Hospital, Linyi 276003, Shandong, China.
authors.forename: Zhen-Ying
authors.initials: ZY
authors.lastname: Liu
authors.affiliation: Department of Kidney Disease and Blood Purification Treatment, Tianjin Institute of Urology, The Second Hospital, Tianjin Medical University, Tianjin 300211, China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Yu
keywords: 5/6 Nephrectomy; Renal failure; Telmisartan