title: Relationship of preoperative neutrophil lymphocyte ratio with prognosis in gastrointestinal stromal tumors.
abstract: OBJECTIVE
  Gastrointestinal stromal tumors are believed to play a role in immunosuppression with their local effect. In some cancers with associated inflammation, an increased pretreatment neutrophil lymphocyte ratio is considered as an indicator of poor prognosis. The aim of our study was to assess the relationship of increased blood neutrophil lymphocyte ratio with disease prognosis in patients with gastrointestinal stromal tumors.
  
  
  METHODS
  The data of 78 patients who underwent surgery with the diagnosis of primary gastrointestinal stromal tumor in our clinic were evaluated retrospectively. The preoperative neutrophil lymphocyte ratio in the peripheral blood was determined. The neutrophil lymphocyte ratio and its relationship with tumor risk and prognosis were compared. The data were evaluated by Pearson's correlation analysis and the Welch ANOVA test.
  
  
  RESULTS
  The preoperative neutrophil lymphocyte ratio was significantly increased in the high-risk groups (p<0.05). An increased preoperative neutrophil lymphocyte ratio was associated with shorter survival (r=-0.32, p=0.009). In addition, an increase in the neutrophil lymphocyte ratio was associated with an increase in the mitotic activity of the tumor (r=-0.364, p=0.025).
  
  
  CONCLUSIONS
  The preoperative neutrophil lymphocyte ratio in gastrointestinal stromal tumors can be used as an indicator of high-risk tumors and poor prognosis.
authors.affiliation: Clinic of General Surgery, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Kargın
authors.affiliation: Department of General Surgery, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Çakır
authors.affiliation: Department of General Surgery, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
authors.forename: Ebubekir
authors.initials: E
authors.lastname: Gündeş
authors.affiliation: Department of General Surgery, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yavuz
authors.affiliation: Department of Medical Pathology, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
authors.forename: Hacı Hasan
authors.initials: HH
authors.lastname: Esen
authors.affiliation: Department of Medical Statistics, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Sinan İyisoy
authors.affiliation: Department of Medical Pathology, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
authors.forename: Naile
authors.initials: N
authors.lastname: Kökbudak
authors.affiliation: Department of General Surgery, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Küçükkartallar
keywords: Gastrointestinal stromal tumor; neutrophil lymphocyte ratio; prognosis