title: Tremor and Klinefelter's Syndrome.
abstract: BACKGROUND
  Klinefelter's syndrome (KS) has been associated with tremor, but reports on tremor phenomenology and treatment are limited.
  
  
  METHODS
  Patient 1 is a 17-year-old male with a dystonic tremor treated with deep brain stimulation (DBS). Patient 2 is a 57-year-old male with a predominant left hand resting tremor and dystonic features.
  
  
  CONCLUSIONS
  Our cases suggest that the tremor in patients with KS may be dystonic in nature. Patient 1 is also the third reported case of successful treatment with DBS. These cases have implications for elucidating the underlying neurobiological mechanism of tremor and identifying treatment options.
authors.affiliation: Atlantic Neuroscience Institute, Summit, NJ, USA.
authors.forename: Marcie L
authors.initials: ML
authors.lastname: Rabin
authors.affiliation: Department of Neurology, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Shivam Om
authors.initials: SO
authors.lastname: Mittal
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Bahman
authors.initials: B
authors.lastname: Jabbari
keywords: 47, XXY; Klinefelter’s; Tremor; deep brain stimulation (DBS); dystonia; sex chromosome