title: Is there a need for an alternative in the era of novel anticoagulants?
abstract: With the development of the new direct oral anticoagulants, many of the unmet needs of the vitamin K antagonists were fulfilled, such as the absence of dietary interactions, few drug interactions, predictable effects and no need for monitoring. However, growing experience with the direct oral anticoagulants indicates there is still room for improvement. Developing antithrombotic agents that optimize their antithrombotic effect while producing little or no risk of bleeding is a long sought after goal. This and other enhanced attributes of candidate drugs are on the horizon.
authors.affiliation: a Hofstra North Shore/LIJ School of Medicine, 15 Waterview Way, Long Branch, NJ 07740, USA.
authors.forename: Jack
authors.initials: J
authors.lastname: Ansell
mesh_terms: D000284:Administration, Oral; D000991:Antithrombins / Q000008:administration & dosage / Q000009:adverse effects*; D055808:Drug Discovery; D004347:Drug Interactions; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans
chemical_list: D000991:Antithrombins
keywords: DOACs; NOACs; anticoagulants; direct oral anticoagulants; novel oral anticoagulants