title: DARPA's Big Mechanism program.
abstract: Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.
authors.affiliation: Defense Advanced Research Projects Agency (DARPA).
authors.forename: Paul R
authors.initials: PR
authors.lastname: Cohen
mesh_terms: D006801:Humans; D008956:Models, Chemical; D009369:Neoplasms / Q000737:chemistry* / Q000503:physiopathology*; D015398:Signal Transduction; D013672:Technology / Q000379:methods*