title: Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels-Alder reaction: an unexpected inversion of enantioselectivity modulated by K(+) and NH4(+) ions.
abstract: We report that K(+) and NH4(+) present different allosteric activation for higher-order human telomeric G-quadruplex DNA metalloenzyme. The obtained major endo products of Diels-Alder reaction can be switched from one preferred configuration in K(+) media (up to 92% ee) to its mirror configuration in NH4(+) media (up to -90% ee).
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. canli@dicp.ac.cn gqjia@dicp.ac.cn.
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Li
authors.forename: Changhao
authors.initials: C
authors.lastname: Wang
authors.forename: Jingya
authors.initials: J
authors.lastname: Hao
authors.forename: Mingpan
authors.initials: M
authors.lastname: Cheng
authors.forename: Guoqing
authors.initials: G
authors.lastname: Jia
authors.forename: Can
authors.initials: C
authors.lastname: Li
mesh_terms: D064751:Ammonium Compounds / Q000737:chemistry*; D021881:DNA, Catalytic / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D007477:Ions / Q000737:chemistry; D011188:Potassium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D064751:Ammonium Compounds; D021881:DNA, Catalytic; D007477:Ions; D011188:Potassium