title: Tannin containing legumes as a model for nutraceuticals against digestive parasites in livestock.
abstract: Parasitic infections with gastrointestinal nematodes (GINs) still represent a worldwide major pathological threat associated with the outdoor production of various livestock species. Because of the widespread resistance to synthetic chemical anthelmintics, there is a strong impetus to explore novel approaches for a more integrated management of these infections. The use of nutraceuticals in the control of GINs is one of the alternatives which has been widely studied for 20 years. The objectives of this review are: (i) to define and illustrate the concept of 'nutraceutical' in the context of veterinary parasitology based on data obtained on the most studied models to control GINs in small ruminants, the tannin-containing legumes (Fabaceae); (ii) to illustrate how the 'nutraceutical concept' could be expanded to other plants, other livestock production systems and other GI parasitic diseases, and (iii) to explain how this concept is opening up new research fields for better understanding the interactions between the host, the digestive parasites and the environment.
authors.affiliation: INRA, UMR 1225 IHAP, 23 Chemin des Capelles, Toulouse F-31076, France; Université de Toulouse, ENVT, 23 Chemin des Capelles, Toulouse F-31076, France. Electronic address: h.hoste@envt.fr.
authors.forename: H
authors.initials: H
authors.lastname: Hoste
authors.affiliation: Campus de Ciencias Biológicas y Agropecuarias, FMVZ, Universidad Autónoma de Yucatán, Km 15.5 Carretera Mérida-Xmatkuil, Merida, Yucatan, Mexico.
authors.forename: J F J
authors.initials: JF
authors.lastname: Torres-Acosta
authors.affiliation: Campus de Ciencias Biológicas y Agropecuarias, FMVZ, Universidad Autónoma de Yucatán, Km 15.5 Carretera Mérida-Xmatkuil, Merida, Yucatan, Mexico.
authors.forename: C A
authors.initials: CA
authors.lastname: Sandoval-Castro
authors.affiliation: University of Reading, School of Agriculture, Policy and Development, 1 Earley Gate, P.O. Box 236, Reading, RG6 6AT, United Kingdom.
authors.forename: I
authors.initials: I
authors.lastname: Mueller-Harvey
authors.affiliation: Veterinary Research Institute - Hellenic Agricultural Organization Demeter, 57001, Thermi, Thessaloniki, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Sotiraki
authors.affiliation: Laboratory of Animal Nutrition, Centre for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, São Paulo, Brazil.
authors.forename: H
authors.initials: H
authors.lastname: Louvandini
authors.affiliation: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
authors.forename: S M
authors.initials: SM
authors.lastname: Thamsborg
authors.affiliation: Fort Valley State University,1005 State University Drive Fort Valley, GA 31030, USA.
authors.forename: T H
authors.initials: TH
authors.lastname: Terrill
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements; D007887:Fabaceae / Q000737:chemistry*; D058751:Livestock / Q000469:parasitology*; D009348:Nematoda / Q000187:drug effects; D009349:Nematode Infections / Q000628:therapy / Q000662:veterinary*; D010273:Parasitic Diseases, Animal / Q000628:therapy*; D010936:Plant Extracts / Q000494:pharmacology; D012418:Ruminants / Q000469:parasitology; D013634:Tannins / Q000494:pharmacology
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts; D013634:Tannins
keywords: Antiparasitic effects; Condensed tannins; Gastrointestinal nematodes; Nutraceuticals; Polyphenols; Small ruminants