title: Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex.
abstract: BACKGROUND
  Phosphoinositides, lipid-signaling molecules, participate in diverse brain processes within a wide metabolic cascade.
  
  
  OBJECTIVE
  Gene transcriptional networks coordinately regulate the phosphoinositide cascade during human brain Development and Aging.
  
  
  METHODS
  We used the public BrainCloud database for human dorsolateral prefrontal cortex to examine age-related expression levels of 49 phosphoinositide metabolic genes during Development (0 to 20+ years) and Aging (21+ years).
  
  
  RESULTS
  We identified three groups of partially overlapping genes in each of the two intervals, with similar intergroup correlations despite marked phenotypic differences between Aging and Development. In each interval, ITPKB, PLCD1, PIK3R3, ISYNA1, IMPA2, INPPL1, PI4KB, and AKT1 are in Group 1, PIK3CB, PTEN, PIK3CA, and IMPA1 in Group 2, and SACM1L, PI3KR4, INPP5A, SYNJ1, and PLCB1 in Group 3. Ten of the genes change expression nonlinearly during Development, suggesting involvement in rapidly changing neuronal, glial and myelination events. Correlated transcription for some gene pairs likely is facilitated by colocalization on the same chromosome band.
  
  
  CONCLUSIONS
  Stable coordinated gene transcriptional networks regulate brain phosphoinositide metabolic pathways during human Development and Aging.
authors.affiliation: Brain Physiology and Metabolism Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America.
authors.forename: Stanley I
authors.initials: SI
authors.lastname: Rapoport
authors.affiliation: Brain Physiology and Metabolism Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Primiani
authors.affiliation: Section on Nutritional Neurosciences, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, United States of America.
authors.forename: Chuck T
authors.initials: CT
authors.lastname: Chen
authors.affiliation: Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States of America.
authors.forename: Kwangmi
authors.initials: K
authors.lastname: Ahn
authors.affiliation: Brain Physiology and Metabolism Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America.
authors.forename: Veronica H
authors.initials: VH
authors.lastname: Ryan
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000235:genetics / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D015870:Gene Expression; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010716:Phosphatidylinositols / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000502:physiology; D055815:Young Adult
chemical_list: D010716:Phosphatidylinositols