title: Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?
abstract: To investigate whether Brucella abortus (BA) antigen injections lead to anemia, and to establish an appropriate Chronic Fatigue Syndrome (CFS) animal model by BA injections, 6 repeated injections of BA antigen were fulfilled every 2 weeks. At a high dose of 1∗10(10) particles/mouse, anemia was induced within 2 weeks and then recovered a lot at the end of the research, while at a moderate dose of 1∗10(8) (3 injections) shifting to 1∗10(9)/mouse (3 injections) anemia was absent. In both groups running wheel activity remained very low even 6 weeks after the last injection.
authors.affiliation: Department of General Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Moriya
authors.affiliation: Department of General Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of General Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Uenishi
authors.affiliation: Department of General Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Akazawa
authors.affiliation: Department of General Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Yamakawa
authors.affiliation: Department of General Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Kobayashi
authors.affiliation: Division of Molecular and Cell Biology, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Ishigaki
mesh_terms: D000740:Anemia / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D001522:Behavior, Animal; D002003:Brucella abortus / Q000737:chemistry*; D004195:Disease Models, Animal; D015673:Fatigue Syndrome, Chronic / Q000139:chemically induced*; D005260:Female; D007267:Injections; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000942:Antigens, Bacterial