title: Latent Expression of the Epstein-Barr Virus (EBV)-Encoded Major Histocompatibility Complex Class I TAP Inhibitor, BNLF2a, in EBV-Positive Gastric Carcinomas.
abstract: The Epstein-Barr virus (EBV) BNLF2a gene product provides immune evasion properties to infected cells through inhibition of transporter associated with antigen processing (TAP)-mediated transport of antigen peptides. Although BNLF2a is considered to be a lytic gene, we demonstrate that it is expressed in nearly half of the EBV-associated gastric carcinomas analyzed. Further, we show that BNLF2a expression is dissociated from lytic gene expression. BNLF2a is therefore expressed in this latency setting, potentially helping protect the infected tumor cells from immunosurveillance.
authors.affiliation: Department of Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA Tulane Cancer Center, New Orleans, Louisiana, USA.
authors.forename: Michael J
authors.identifier: http://orcid.org/0000-0001-9930-3578
authors.initials: MJ
authors.lastname: Strong
authors.affiliation: Department of Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA Tulane Cancer Center, New Orleans, Louisiana, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Laskow
authors.affiliation: Department of Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA Tulane Cancer Center, New Orleans, Louisiana, USA.
authors.forename: Hani
authors.initials: H
authors.lastname: Nakhoul
authors.affiliation: Department of Microbiology, Immunology & Parasitology, Louisiana State University School of Medicine, New Orleans, Louisiana, USA.
authors.forename: Eugene
authors.initials: E
authors.lastname: Blanchard
authors.affiliation: Department of Biostatistics and Bioinformatics, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
authors.forename: Yaozhong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA Tulane Cancer Center, New Orleans, Louisiana, USA.
authors.forename: Melody
authors.initials: M
authors.lastname: Baddoo
authors.affiliation: Department of Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA Tulane Cancer Center, New Orleans, Louisiana, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Tulane Cancer Center, New Orleans, Louisiana, USA Department of Pulmonary Diseases, Critical Care, and Environmental Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
authors.forename: Qinyan
authors.initials: Q
authors.lastname: Yin
authors.affiliation: Department of Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA Tulane Cancer Center, New Orleans, Louisiana, USA erik@tulane.edu.
authors.forename: Erik K
authors.initials: EK
authors.lastname: Flemington
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors*; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000821:virology*; D015870:Gene Expression; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D013274:Stomach Neoplasms / Q000276:immunology* / Q000821:virology*; D019139:Tumor Escape; D014763:Viral Matrix Proteins / Q000235:genetics* / Q000276:immunology
chemical_list: D018528:ATP-Binding Cassette Transporters; C539239:BNLF21 protein, human herpesvirus 4; D015395:Histocompatibility Antigens Class I; D014763:Viral Matrix Proteins; C477327:transporter associated with antigen processing (TAP)