title: Study on the interaction of Fe(III) complex of BODIPY appended di(picolyl)amine with water and HeLa cells.
abstract: The iron complex [(m-BDA)FeCl3] (Fe1) (m-BDA=8-[di(2-picolyl)amine-3-benzyl]-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene) was characterized by spectroscopic methods. The emission intensity of Fe1 is weaker than that of m-BDA due to the electrostatic interaction between the Fe(III) ion and m-BDA. However, the coordination of water with the central Fe(III) ion in Fe1 changed metal-ligand charge transfer, thus the quenched emission at 509 nm was recovered. Furthermore, Fe1 can catalyze water oxidation to generate dioxygen when irradiated by green LED light (10W). In particular, the Fe1 can enter into HepG-2 cells and show different inhibition rates in black and under irradiation. The anticancer activity of Fe1 was greatly enhanced under irradiation. Our results demonstrate that Fe(III) complexes of BODIPY can be developed as new kinds of photodynamic agents.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Meng-Yun
authors.initials: MY
authors.lastname: Kong
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China. Electronic address: chenqy@ujs.edu.cn.
authors.forename: Qiu-Yun
authors.initials: QY
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Xu
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Lu
mesh_terms: D000588:Amines / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D055664:Electrochemical Techniques; D005290:Ferric Compounds / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057054:Molecular Imaging / Q000379:methods; D010084:Oxidation-Reduction; D010848:Picolinic Acids / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry
chemical_list: C501847:2,2'-dipicolylamine; C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000588:Amines; D001896:Boron Compounds; D005290:Ferric Compounds; D005456:Fluorescent Dyes; D010848:Picolinic Acids; C000610350:trichloro(8-(di(2-picolyl)amine-3-benzyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene)iron(III); D014867:Water
keywords: Anticancer; Fe(III) complex; Photodynamic; Water oxidation