title: Modulation of nuclear receptor activity by the F domain.
abstract: The F domain located at the C-terminus of proteins is one of the least conserved regions of the estrogen receptors alpha and beta, members of the nuclear hormone receptor superfamily. Indeed, many members of the superfamily lack the F domain. However, when present, removing the F domain entirely or mutating it alters transactivation, dimerization, and the responses to agonist and antagonist ligands. This review focuses on the functions of the F domain of the estrogen receptors, particularly in relation to other members of the superfamily.
authors.affiliation: Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Shivali R
authors.initials: SR
authors.lastname: Patel
authors.affiliation: Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: dskafar@med.wayne.edu.
authors.forename: Debra F
authors.initials: DF
authors.lastname: Skafar
mesh_terms: D065171:Estrogen Receptor Antagonists / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D011487:Protein Conformation / Q000187:drug effects; D017434:Protein Structure, Tertiary / Q000187:drug effects; D011960:Receptors, Estrogen / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D065171:Estrogen Receptor Antagonists; D004967:Estrogens; D011960:Receptors, Estrogen
keywords: Estrogen; Estrogen receptor; Nuclear hormone receptor superfamily