title: Catalytic dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using iPr3SiH and CO2.
abstract: A versatile method has been found to catalyze the dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using Pd/C, volatile iPr3SiH and CO2 gas without the liberation of any salts. A simple filtration/evaporation process facilitates the easy isolation of the product, thereby enhancing the utility of Tsoc as an amine-protecting group in organic synthesis.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8601, Japan. kitamura@os.rcms.nagoya-u.ac.jp.
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Yamamura
authors.forename: S
authors.initials: S
authors.lastname: Nakane
authors.forename: M
authors.initials: M
authors.lastname: Kitamura
mesh_terms: D000588:Amines / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D014297:Trimethylsilyl Compounds; D002245:Carbon Dioxide