title: Rational Design of Multifunctional Gold Nanoparticles via Host-Guest Interaction for Cancer-Targeted Therapy.
abstract: A versatile gold nanoparticle-based multifunctional nanocomposite AuNP@CD-AD-DOX/RGD was constructed flexibly via host-guest interaction for targeted cancer chemotherapy. The pH-sensitive anticancer prodrug AD-Hyd-DOX and the cancer-targeted peptide AD-PEG8-GRGDS were modified on the surface of AuNP@CD simultaneously, which endowed the resultant nanocomposite with the capability to selectively eliminate cancer cells. In vitro studies indicated that the AuNP@CD-AD-DOX/RGD nanocomposite was preferentially uptaken by cancer cells via receptor-mediated endocytosis. Subsequently, anticancer drug DOX was released rapidly upon the intracellular trigger of the acid microenvirenment of endo/lysosomes, inducing apoptosis in cancer cells. As the ideal drug nanocarrier, the multifunctional gold nanoparticles with the active targeting and controllable intracellular release ability hold the great potential in cancer therapy.
authors.forename: Wei-Hai
authors.initials: WH
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Lei
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Luo
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Sheng
authors.initials: S
authors.lastname: Hong
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Liu
authors.forename: Yin-Jia
authors.initials: YJ
authors.lastname: Cheng
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000218:Adamantane / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D019556:COS Cells; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D065546:Drug Liberation; D004705:Endocytosis; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D018613:Microscopy, Confocal; D053761:Nanocomposites / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D006046:Gold; D006108:Graphite; D004317:Doxorubicin; C031215:betadex; D000218:Adamantane
keywords: Multifunctional; gold nanoparticles; host−guest interaction; targeted therapy; triggered release