title: FBXO31 promotes cell proliferation, metastasis and invasion in lung cancer.
abstract: FBXO31 is a member of F-box family which is involved in diverse biological functions and development of disease. Recent reports in breast cancer, hepatocellular carcinoma and ovarian cancer demonstrated inhibitory effect of FBXO31 on proliferation and tumorigenesis. However, the function of FBXO31 is not analyzed in lung cancer so far. In this study, we reported that expression of FBXO31 was higher in lung cancer tissues compared with non-cancerous lung tissues, and that higher expression of FBXO31 was significantly associated with tumor size, tumor infiltration, clinical stages and lymph node metastasis. In addition, exogenous expression of FBXO31 promoted cell growth, metastasis and invasion in A549 cells. Conversely, silencing FBXO31 by specific siRNA caused inhibitory effect on cell growth, metastasis and invasion. Moreover, tumorigenicity assays in nude mice showed FBXO31 promoted tumor growth in vivo. In conclusion, our data suggest FBXO31 promotes cell proliferation, metastasis and invasion in lung cancer.
authors.affiliation: Clinical Research Center, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Huang
authors.affiliation: Clinical Research Center, Guangdong Medical College Zhanjiang 524001, China ; Department of Respiratory Medicine, Affiliated hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Clinical Research Center, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Ya-Hong
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Clinical Research Center, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Chen
authors.affiliation: Clinical Research Center, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: He
authors.affiliation: The First Affiliated Hospital, Medical School of Xi'an Jiaotong University China ; Clinical Research Center, The Affiliated Hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Tie
authors.initials: T
authors.lastname: Liu
authors.affiliation: Clinical Research Center, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Yang
authors.affiliation: Clinical Research Center, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: La-Wei
authors.initials: LW
authors.lastname: Yang
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated Hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, Affiliated hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Ze-Qing
authors.initials: ZQ
authors.lastname: Song
authors.affiliation: Department of Respiratory Medicine, Affiliated hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Yao
authors.affiliation: Department of Respiratory Medicine, Affiliated hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.affiliation: Clinical Research Center, Guangdong Medical College Zhanjiang 524001, China ; Department of Respiratory Medicine, Affiliated hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
keywords: FBXO31; invasion; lung cancer; metastasis; tumor growth