title: Concise Review: Induced Pluripotent Stem Cells as New Model Systems in Oncology.
abstract: The demonstration that pluripotent stem cells could be generated by somatic cell reprogramming led to wonder if these so-called induced pluripotent stem (iPS) cells would extend our investigation capabilities in the cancer research field. The first iPS cells derived from cancer cells have now revealed the benefits and potential pitfalls of this new model. iPS cells appear to be an innovative approach to decipher the steps of cell transformation as well as to screen the activity and toxicity of anticancer drugs. A better understanding of the impact of reprogramming on cancer cell-specific features as well as improvements in culture conditions to integrate the role of the microenvironment in their behavior may strengthen the epistemic interest of iPS cells as model systems in oncology.
authors.affiliation: Gustave Roussy Cancer Center, Villejuif, Paris, France.|INSERM, UMR1170, Villejuif, Paris, France.|Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, Paris, France.|Université Paris I-Panthéon Sorbonne, Institut d'Histoire et de Philosophie des Sciences et des Techniques, Paris, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Laplane
authors.affiliation: Gustave Roussy Cancer Center, Villejuif, Paris, France.|INSERM, UMR1170, Villejuif, Paris, France.|Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, Paris, France.
authors.forename: Allan
authors.initials: A
authors.lastname: Beke
authors.affiliation: Gustave Roussy Cancer Center, Villejuif, Paris, France.|INSERM, UMR1170, Villejuif, Paris, France.|Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, Paris, France.
authors.forename: William
authors.initials: W
authors.lastname: Vainchenker
authors.affiliation: Gustave Roussy Cancer Center, Villejuif, Paris, France.|INSERM, UMR1170, Villejuif, Paris, France.|Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Solary
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D065150:Cellular Reprogramming / Q000235:genetics*; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D009369:Neoplasms / Q000235:genetics*
keywords: Cancer; Clonal evolution; Genetic predisposition; Induced pluripotent stem cells