title: Palladium(0)-Catalyzed Methylcyclopropanation of Norbornenes with Vinyl Bromides and Mechanism Study.
abstract: An unusual methylcyclopropanation from [2 + 1] cycloadditions of vinyl bromides to norbornenes catalyzed by Pd(OAc)2/PPh3 in the presence of CH3ONa and CH3OH has been established. A methylcyclopropane subunit was installed by a 3-fold domino procedure involving a key protonation course. Preliminary deuterium-labeling studies revealed that the proton came from methyl of CH3OH and also exposed an additional hydrogen/deuterium exchange process. These two proton-concerned reactions were fully chemoselective.
authors.affiliation: †Department of Chemistry, Zhejiang University, Hangzhou 310028, Zhejiang, P.R. China.|‡School of Metallurgy and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, Jiangxi, P.R. China.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Mao
authors.affiliation: §School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, Zhejiang P.R. China.
authors.forename: Hujun
authors.initials: H
authors.lastname: Xie
authors.affiliation: †Department of Chemistry, Zhejiang University, Hangzhou 310028, Zhejiang, P.R. China.
authors.forename: Weiliang
authors.initials: W
authors.lastname: Bao