title: Hypersensitivity to Tomato (Lycopersicon esculentum) in Peach-Allergic Patients: rPrup 3 and rPrup 1 Are Predictive of Symptom Severity.
abstract: Background: The role of allergens in the severity of tomato allergy symptoms has not yet been studied.
  
  
  OBJECTIVE
  To evaluate the relationship between severe allergic reactions to peach and tomato and between tomato allergy symptoms and the pattern of IgE positivity for rPru p 1, rPru p 3, rPru p 4, rBetv 1, rBetv 2, rBetv4, rPhl p 1, and rPhl p 12 in order to identify the role of recombinant allergens in the severity of reactions to tomato.
  
  
  METHODS
  We studied peach-allergic patients with clinical reactions to tomato by performing an open food challenge, skin prick test, and determination of serum specific IgE to tomato and to recombinant peach, birch, and grass allergens. Statistical analysis was carried out to evaluate the relationship between the severity of tomato symptoms and IgE positivity to the different allergens and to peach-induced symptoms.
  
  
  RESULTS
  We found a significant association between severe reactions to tomato and severe reactions to peach (P = .01 7) and levels of IgE to rPru p3 (P = .029) and between mild tomato allergy symptoms and levels of IgE to rPru p1 (P = .047), anti-rBetv 1 (P = .0414), anti-rBetv 2 (P = .0457), and Phleum pratense (P = .0022).
  
  
  CONCLUSIONS
  We observed a significant relationship between peach and symptoms of tomato allergy. IgE positivity for rPru p3 seems to be a surrogate biochemical marker for severe tomato allergy, whereas the presence of anti-rPru p 1 IgE may be an indicator of mild tomato allergy.
authors.forename: A
authors.initials: A
authors.lastname: Mascheri
authors.forename: L
authors.initials: L
authors.lastname: Farioli
authors.forename: V
authors.initials: V
authors.lastname: Pravettoni
authors.forename: M
authors.initials: M
authors.lastname: Piantanida
authors.forename: C
authors.initials: C
authors.lastname: Stafylaraki
authors.forename: J
authors.initials: J
authors.lastname: Scibilia
authors.forename: C
authors.initials: C
authors.lastname: Mirone
authors.forename: D
authors.initials: D
authors.lastname: Preziosi
authors.forename: M
authors.initials: M
authors.lastname: Nichelatti
authors.forename: E A
authors.initials: EA
authors.lastname: Pastorello
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D052179:Antigens, Plant / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D005638:Fruit; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests; D007558:Italy; D018551:Solanum lycopersicum / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010940:Plant Proteins / Q000276:immunology*; D011237:Predictive Value of Tests; D027861:Prunus / Q000009:adverse effects* / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D012698:Serologic Tests; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D052179:Antigens, Plant; D015415:Biomarkers; D010940:Plant Proteins; C403252:Pru p 1 allergen; C463181:Pru p 3 allergen; D011994:Recombinant Proteins; D007073:Immunoglobulin E