title: 99m-Tc-ubiquicidin scintigraphy in diagnosis of knee prosthesis infection and comparison with F-18 fluorodeoxy-glucose positron emission tomography/computed tomography.
abstract: Total knee arthroplasty has witnessed a significant increase in recent years. Despite the advantages of this surgical procedure, it has some complications, the most serious of which is prosthetic infection. The discrimination of bacterial infections from sterile inflammatory processes is of great importance in the management of periprosthetic infection (PPI). Ubiquicidin (UBI) is a synthetic antimicrobial peptide fragment reported to be highly infection-specific. Tc99m-UBI has recently been reported to be a promising radiotracer for infection imaging. We report a case of left knee PPI diagnosed using 99mTc-UBI scintigraphy and compared with F-18 fluorodeoxy-glucose positron emission tomography.
authors.affiliation: Department of Nuclear Medicine, PET/CT and Radionuclide Therapy, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Koramadai Karuppusamy
authors.initials: KK
authors.lastname: Kamaleshwaran
authors.affiliation: Department of Orthopedics, Ganga Medical Centre and Hospitals Private Limited, Coimbatore, Tamil Nadu, India.
authors.forename: N
authors.initials: N
authors.lastname: Rajkumar
authors.affiliation: Department of Nuclear Medicine, PET/CT and Radionuclide Therapy, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Vyshak
authors.initials: V
authors.lastname: Mohanan
authors.affiliation: Department of Nuclear Medicine, PET/CT and Radionuclide Therapy, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Kalarikal
authors.affiliation: Department of Nuclear Medicine, PET/CT and Radionuclide Therapy, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Ajit Sugunan
authors.initials: AS
authors.lastname: Shinto
keywords: Knee joint; Tc99m-ubiquicidin; fluorodeoxy-glucose-positron emission tomography; prosthetic infection