title: Two Cases of Granulomatous Mastitis Caused by Corynebacterium kroppenstedtii Infection in Nulliparous Young Women with Hyperprolactinemia.
abstract: Recently, an association between granulomatous mastitis and local infection with Corynebacterium (C.) kroppenstedtii has been suggested. We herein report two cases of granulomatous mastitis resulting from C. kroppenstedtii infection in nulliparous young women with hyperprolactinemia. Both cases involved nulliparous patients with drug-induced hyperprolactinemia, and both individuals received incision and drainage, after which the pus was sent to our laboratory. Corynebacterium spp. grew on blood agar, and 16S rRNA gene sequencing identified the pathogen as C. kroppenstedtii. In conclusion, lactational changes caused by drug-induced hyperprolactinemia may increase the risk of granulomatous mastitis after C. kroppenstedtii infection.
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kutsuna
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Mezaki
authors.forename: Maki
authors.initials: M
authors.lastname: Nagamatsu
authors.forename: Junwa
authors.initials: J
authors.lastname: Kunimatsu
authors.forename: Kei
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fujiya
authors.forename: Momoko
authors.initials: M
authors.lastname: Mawatari
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeshita
authors.forename: Kayoko
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kato
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kanagawa
authors.forename: Norio
authors.initials: N
authors.lastname: Ohmagari
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003352:Corynebacterium / Q000235:genetics / Q000302:isolation & purification*; D003354:Corynebacterium Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D004322:Drainage; D005260:Female; D058890:Granulomatous Mastitis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications*; D064704:Levofloxacin / Q000627:therapeutic use; D011388:Prolactin / Q000378:metabolism; D012336:RNA, Ribosomal, 16S / Q000302:isolation & purification; D013469:Sulpiride / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S; D064704:Levofloxacin; D013469:Sulpiride; D011388:Prolactin