title: [CENTRAL NERVOUS SYSTEM INVOLVEMENT IN GRANULOMATOSIS WITH POLYANGIITIS (GPA)].
abstract: We present the case of a 75 year-old female with Wegener's Granulomatosis. The patient arrived intubated to the emergency room, following loss of consciousness and a generalized seizure. A magnetic resonance imaging brain scan revealed a space occupying lesion (SOL) in the right temporal region. Subsequent investigation indicated the SOL to be a primary lymphoma of the central nervous system. The clinical manifestations of granulomatosis with polyangiitis on both the central and peripheral nervous systems are reviewed herein, as well as the appropriated treatment modalities and the link between this disease and various malignancies.
authors.forename: Yuval
authors.initials: Y
authors.lastname: Horovitz
authors.forename: Merav
authors.initials: M
authors.lastname: Lidar
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D024221:Antineoplastic Protocols; D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D003399:Craniotomy / Q000379:methods*; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005629:Frozen Sections / Q000379:methods; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000276:immunology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D008727:Methotrexate / Q000008:administration & dosage*; D011878:Radiotherapy / Q000379:methods*; D012640:Seizures / Q000209:etiology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods; D014474:Unconsciousness / Q000209:etiology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate