title: Is platelet mass a more significant indicator than platelet count of closure of patent ductus arteriosus?
abstract: BACKGROUND
  The purpose of this study was to evaluate whether or not platelet mass contributes to closure of patent ductus arteriosus (PDA) in premature newborns.
  
  
  METHODS
  This retrospective study included 115 preterm newborns with hemodynamically significant PDA (hPDA) and 120 newborns without PDA. The newborns' platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) were noted from their files and the platelet mass (platelet count plus MPV/10(3)) was calculated. Patients with congenital abnormality, persistent pulmonary hypertension or sepsis were not included in the study.
  
  
  RESULTS
  Platelet count and PDW were found to not be risk factors for closure of hPDA (p > 0.05), but both high platelet mass (OR 1.25; 95% CI 1.12-1.41) and MPV (OR 1.87; 95% CI 2.52-3.85) were determined to be independent risk factors for hPDA.
  
  
  CONCLUSIONS
  Platelet mass may be a more significant indicator than platelet count of closure of hPDA in preterm newborns.
authors.affiliation: a Department of Pediatrics, Division of Neonatology .
authors.forename: Nihat
authors.initials: N
authors.lastname: Demir
authors.affiliation: a Department of Pediatrics, Division of Neonatology .
authors.forename: Erdal
authors.initials: E
authors.lastname: Peker
authors.affiliation: b Department of Pediatrics, Division of Cardiology .
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Ece
authors.affiliation: c Department of Pediatric Surgery , and.
authors.forename: Kemal
authors.initials: K
authors.lastname: Ağengin
authors.affiliation: d Department of Pediatrics, Division of Endocrinology , Yuzuncu Yil University School of Medicine , Van , Turkey.
authors.forename: Keziban Asli
authors.initials: KA
authors.lastname: Bulan
authors.affiliation: a Department of Pediatrics, Division of Neonatology .
authors.forename: Oğuz
authors.initials: O
authors.lastname: Tuncer
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D016022:Case-Control Studies; D004374:Ductus Arteriosus, Patent / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010976:Platelet Count
keywords: Ductus arteriosus; platelet count; platelet mass; preterm newborn