title: Long-Term Risk of Progressive Chronic Kidney Disease in Patients with Severe Acute Kidney Injury Requiring Dialysis after Coronary Artery Bypass Surgery.
abstract: OBJECTIVE
  Few studies have evaluated patients after cardiac surgery for subsequent chronic kidney disease (CKD) which increases cardiovascular morbidity and mortality. This study aimed to ascertain the long-term renal outcome in adult patients with severe acute kidney injury (AKI) after coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  This is a single-center retrospective cohort study of consecutive adult patients who received acute dialysis for AKI after CABG between February 8, 2009 and January 30, 2011. Data on pre- and intra-operative factors were retrieved from electronic medical records. The primary endpoint was CKD progression as defined by dialysis dependence or doubling of serum creatinine from the pre-operative level. Secondary endpoints included in-hospital mortality and renal function at 3 months and 1 year.
  
  
  RESULTS
  Fifty-five patients required acute dialysis after CABG. The median age was 67 years (IQR: 61, 75), and 70.9% were male. Median pre-operative serum creatinine was 157 µmol/l (IQR: 122, 203). A total of 19 patients (34.5%) died. The median follow-up time for hospital survivors was 44.2 months (IQR: 25.0, 49.4) after surgery. Among the 36 survivors, 14 patients (38.9%) reached the primary endpoint. Patients with CKD progression had higher pre-operative serum creatinine [median 214 µmol/l (IQR: 159, 399) vs. 155 µmol/l (112, 187), p = 0.015] and lower eGFR [median 20.4 ml/min/1.73 m(2) (IQR: 11.9, 38.2) vs. 39.9 ml/min/1.73 m(2) (25.9, 55.5), p = 0.027] compared to those who did not have CKD progression.
  
  
  CONCLUSIONS
  Patients with severe AKI after CABG are at high risk of long-term renal dysfunction and should be monitored regularly for deterioration.
authors.affiliation: Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
authors.forename: Cynthia C
authors.initials: CC
authors.lastname: Lim
authors.affiliation: Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
authors.forename: Chieh Suai
authors.initials: CS
authors.lastname: Tan
authors.affiliation: Department of Cardiothoracic Surgery, National Heart Center, Singapore, Singapore.
authors.forename: Cynthia M L
authors.initials: CM
authors.lastname: Chia
authors.affiliation: Department of Cardiothoracic Surgery, National Heart Center, Singapore, Singapore.
authors.forename: Ann Kheng
authors.initials: AK
authors.lastname: Tan
authors.affiliation: Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
authors.forename: Jason C J
authors.initials: JC
authors.lastname: Choo
authors.affiliation: Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
authors.forename: Manish
authors.initials: M
authors.lastname: Kaushik
authors.affiliation: Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
authors.forename: Han Khim
authors.initials: HK
authors.lastname: Tan
keywords: Acute kidney injury; Chronic kidney disease; Coronary artery bypass; Intensive care; Kidney failure; Renal replacement therapy