title: Faux pas recognition performance in a help-seeking population at clinical high risk of psychosis.
abstract: There is a growing body of evidence suggesting that patients with psychosis show impaired theory of mind (ToM). However, much remains to be understood as to whether ToM deficits occur in the premorbid or post-onset period of psychosis. Our primary aim was to examine empirically impairment on ToM tasks in a group of individuals with clinical high risk (CHR) of psychosis. Fifty CHR participants identified through the Structured Interview for Prodromal Syndromes and 52 age-/education-matched controls were assessed with a complete standard neuropsychological battery (the MCCB, MATRICS Consensus Cognitive Battery) and a social cognition assessment (Faux Pas Test, FPT). We then examined the association of baseline FPT performance with conversion to psychosis at 12-month follow-up. Compared with controls, the CHR group showed significantly poorer performances on the FPT and most MCCB domains. Significant positive correlations were found between faux pas detection and the MCCB domains of Attention/Vigilance and Working Memory in CHR participants when controlling for age and years of education. Mean scores on the FPT in 14 converters who were diagnosed with full-blown psychosis within 12 months were significantly lower than they were for non-converters. Impairments in ToM ability are acquired earlier in the prodromal stage of psychosis, along with general cognition (such as memory function) deficits. Declines in ToM ability may overlap with the progress of psychosis (the gradual loss insight), sharing similar neural substrates, and reflected by impairments in basic cognitive function.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: TianHong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: ZhengHui
authors.initials: Z
authors.lastname: Yi
authors.affiliation: Department of Psychology, Florida A&M University, Tallahassee, FL, 32307, USA.|Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, 75 Fenwood Rd, Boston, MA, 02115, USA.
authors.forename: HuiJun
authors.initials: H
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: HuiRu
authors.initials: H
authors.lastname: Cui
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: YingYing
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: LiHua
authors.initials: L
authors.lastname: Xu
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: ZhenYing
authors.initials: Z
authors.lastname: Qian
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: YiKang
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: LiJuan
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Psychological Medicine, Changi General Hospital, Singapore, Singapore.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Chow
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: ChunBo
authors.initials: C
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: KaiDa
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. xiaozeping88@163.com.
authors.forename: ZePing
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. jijunwang27@163.com.
authors.forename: JiJun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D000066505:Help-Seeking Behavior; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D021641:Recognition, Psychology / Q000502:physiology*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D056345:Theory of Mind; D055815:Young Adult
keywords: Conversion; Prodromal psychosis; Social cognition; Ultra high risk; Working memory