title: Cytologic features of gastric-type adenocarcinoma of the uterine cervix.
abstract: BACKGROUND
  Gastric-type mucinous carcinoma (GAS) is a clinically aggressive variant of cervical adenocarcinoma. This study sought to describe the cytologic features of GAS.
  
  
  METHODS
  We reviewed the cervical and endometrial smears of 14 patients with a histopathologic diagnosis of GAS. All slides were conventionally smeared. We included 20 controls with usual-type endocervical adenocarcinoma (UEA).
  
  
  RESULTS
  Monolayered and honeycomb sheets were observed in 78.6% (11/14) of patients with GAS, and were prominent in seven patients. Three-dimensional clusters were more prominent in the UEA group. Vacuolar and/or foamy cytoplasm was observed in 71.4% (10/14) of patients with GAS, whereas this finding was rare among those with UEA (2/18). Marked intracytoplasmic neutrophil entrapment was more common in the GAS group (7/14) than in the UEA group (2/18). Intracytoplasmic mucin was present in eight patients with GAS. Nuclei were vesicular in eight patients with GAS, but were homogenous and hyperchromatic in UEA patients. Conspicuous nucleoli were present in nine patients with GAS. Conversely, this finding was rarely observed in UEA patients.
  
  
  CONCLUSIONS
  The characteristic cytologic findings of GAS include (1) monolayered and honeycomb sheets, (2) vacuolar and/or foamy cytoplasm, (3) intracytoplasmic neutrophil entrapment, and (4) vesicular nuclei with prominent nucleoli.
authors.affiliation: Department of Diagnostic Pathology, Kobe University Hospital, Kobe, Japan.|Department of Diagnostic Pathology, Hyogo Cancer Center, Kobe, Japan.
authors.forename: Fumi
authors.initials: F
authors.lastname: Kawakami
authors.affiliation: Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Mikami
authors.affiliation: Department of Gynecologic Oncology, Hyogo Cancer Center, Kobe, Japan.|Section of Translational Research, Hyogo Cancer Center, Kobe, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sudo
authors.affiliation: Department of Gynecologic Oncology, Hyogo Cancer Center, Kobe, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: Department of Diagnostic Pathology, Hyogo Cancer Center, Kobe, Japan.|Department of Community Medicine and Social Healthcare Science, Division of Pathology for Regional Communication, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Hirose
authors.affiliation: Department of Diagnostic Pathology, Kobe University Hospital, Kobe, Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Itoh
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000166:cytology* / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014626:Vaginal Smears
keywords: Pap smear; cervical adenocarcinoma; cervical cancer screening; gastric-type mucinous carcinoma; minimal deviation adenocarcinoma