title: Self-maintenance of neurogenic inflammation contributes to a vicious cycle in skin.
abstract: Cutaneous neurogenic inflammation (CNI) is frequently associated with skin disorders. CNI is not limited to the retrograde signalling of nociceptive sensory nerve endings but can instead be regarded as a multicellular phenomenon. Thus, soluble mediators participating in communication among sensory nerves, skin and immune cells are key components of CNI. These interactions induce the self-maintenance of CNI, promoting a vicious cycle. Certain G protein-coupled receptors (GPCRs) play a prominent role in these cell interactions and contribute to self-maintenance. Protease-activated receptors 2 and 4 (PAR-2 and PAR-4, respectively) and Mas-related G protein-coupled receptors (Mrgprs) are implicated in the synthesis and release of neuropeptides, proteases and soluble mediators from most cutaneous cells. Regulation of the expression and release of these mediators contributes to the vicious cycle of CNI. The authors propose certain hypothetical therapeutic options to interrupt this cycle, which might reduce skin symptoms and improve patient quality of life.
authors.affiliation: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France.|Uriage Dermatological Laboratories, Courbevoie, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Gouin
authors.affiliation: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lebonvallet
authors.affiliation: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France.
authors.forename: Killian
authors.initials: K
authors.lastname: L'Herondelle
authors.affiliation: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Le Gall-Ianotto
authors.affiliation: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Buhé
authors.affiliation: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Plée-Gautier
authors.affiliation: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Carré
authors.affiliation: Uriage Dermatological Laboratories, Courbevoie, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Lefeuvre
authors.affiliation: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Misery
mesh_terms: D000818:Animals; D006801:Humans; D055633:Immune System Phenomena; D020078:Neurogenic Inflammation / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D044464:Receptor, PAR-2 / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D018179:Receptors, Thrombin / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism; D012871:Skin Diseases / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D044464:Receptor, PAR-2; D043562:Receptors, G-Protein-Coupled; D018179:Receptors, Thrombin; C112908:protease-activated receptor 4
keywords: PAR; inflammation; mrgpr; neurogenic; neurotransmitter; skin