title: The Correlation Between Diffusion-Weighted Imaging at 3.0-T Magnetic Resonance Imaging and Histopathology for Pancreatic Ductal Adenocarcinoma.
abstract: OBJECTIVE
  The aim of this study was to discuss the correlation between diffusion-weighted imaging (DWI) at 3.0-T magnetic resonance and histopathology for pancreatic ductal adenocarcinoma (PDA).
  
  
  METHODS
  Twenty-eight patients with histopathologically proven PDA were included in this study after 108 cases of suspected pancreatic tumors had been performed with DWI. The sequences of DWI included respiratory-triggered DWI and breath-hold DWI, which were performed with 2 b values (0 and 500 s/mm; 0 and 1000 s/mm), respectively. According to magnetic resonance images, wax blocks and slices were selected and stained with hematoxylin-eosin for anti-vascular endothelial growth factor (VEGF), anti-CD34, and anti-Ki-67 (Mib-1). The relationship between tumor apparent diffusion coefficient (ADC) and tumor fibrosis, as well as the expression of tumor VEGF, Ki-67, and multivessel density (MVD), were studied.
  
  
  RESULTS
  The ADC values of PDA of different grades of differentiation and fibrosis grade did not show statistically significant difference. The ADC values of PDA did not show the statistically significant correlation with the grades of differentiation, fibrosis grade, Ki-67 expression, and expression of VEGF and MVD.
  
  
  CONCLUSIONS
  The ADC of PDA cannot be used to reflect grades of differentiation, degree of tumor fibrosis, the expression of VEGF, the expression of Ki-67, and the tumor MVD.
authors.affiliation: From the *Department of Radiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu; †Department of Radiology, Fudan University Shanghai Cancer Center, and ‡Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Kefu
authors.initials: K
authors.lastname: Liu
authors.forename: Weijun
authors.initials: W
authors.lastname: Peng
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D015203:Reproducibility of Results; D012189:Retrospective Studies