title: Vaccination with a multicomponent meningococcal B vaccine in prevention of disease in adolescents and young adults.
abstract: Vaccination programs employing capsular-based meningococcal vaccines have proved successful in a variety of settings globally since first introduced over 40 years ago. Similar successes have been demonstrated using meningococcal vaccines for use against serogroup B (MenB) outbreak strains but the diversity of MenB strains has limited vaccine use outside targeted geographic regions. MenB continues to be a significant cause of outbreaks in adolescents and young adults, as recently demonstrated in university settings in the US (Princeton, New Jersey and Santa Barbara, California) and has the potential for hyperendemic disease levels such as currently experienced in Québec and the United Kingdom. In adolescents, increased endemic disease rates and outbreak potential are likely associated with social behaviors putting individuals at risk for carriage acquisition and may explain regional and temporal variations in epidemiology. A protein-based, multi-component MenB vaccine (4CMenB) is currently licensed for use in 37 countries including EU/EEA countries, Australia, Canada, Chile, Colombia, Uruguay, and the US. In this article we review the most recent clinical trial data with 4CMenB with a focus on adolescents and young adults. The vaccine appears to have an acceptable safety profile and is well-tolerated in adolescents and young adults while providing robust, persistent levels of bactericidal antibodies considered protective for each of the four antigenic components of the vaccine. With the recent availability of this vaccine, health care providers have the first comprehensive opportunity to control meningococcal disease, a highly disruptive public health problem with a disproportionate impact on adolescents and young adults.
authors.affiliation: Melbourne School of Population and Global Health, The University of Melbourne, and Murdoch Children's Research Institute, Victoria 3010, Australia.
authors.forename: Terry
authors.initials: T
authors.lastname: Nolan
authors.affiliation: Programa de Microbiología y Micología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Avda Independencia 1027, Santiago, Chile.
authors.forename: Miguel
authors.initials: M
authors.lastname: O'Ryan
authors.affiliation: Novartis Vaccines and Diagnostics Inc., 350 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: jimwassil@yahoo.com.
authors.forename: James
authors.initials: J
authors.lastname: Wassil
authors.affiliation: Novartis Vaccines and Diagnostics, Inc., S.A.S.10, Rue Chevreul, F-92150 Suresnes, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Abitbol
authors.affiliation: Novartis Vaccines and Diagnostics Inc., 350 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Dull
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D001770:Blood Bactericidal Activity; D014943:Global Health; D006801:Humans; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D038541:Neisseria meningitidis, Serogroup B / Q000276:immunology*; D055815:Young Adult
chemical_list: C570015:4CMenB vaccine; D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines
keywords: Adolescents; Meningitis; Meningococcal B vaccine; Outbreak; Prevention; University