title: Neural regulation of the kidney function in rats with cisplatin induced renal failure.
abstract: OBJECTIVE
  Chronic kidney disease (CKD) is often associated with a disturbed cardiovascular homeostasis. This investigation explored the role of the renal innervation in mediating deranged baroreflex control of renal sympathetic nerve activity (RSNA) and renal excretory function in cisplatin-induced renal failure.
  
  
  METHODS
  Rats were either intact or bilaterally renally denervated 4 days prior to receiving cisplatin (5 mg/kg i.p.) and entered a chronic metabolic study for 8 days. At day 8, other groups of rats were prepared for acute measurement of RSNA or renal function with either intact or denervated kidneys.
  
  
  RESULTS
  Following the cisplatin challenge, creatinine clearance was 50% lower while fractional sodium excretion and renal cortical and medullary TGF-β1 concentrations were 3-4 fold higher in both intact and renally denervated rats compared to control rats. In cisplatin-treated rats, the maximal gain of the high-pressure baroreflex curve was only 20% that of control rats, but following renal denervation not different from that of renally denervated control rats. Volume expansion reduced RSNA by 50% in control and in cisplatin-treated rats but only following bilateral renal denervation. The volume expansion mediated natriuresis/diuresis was absent in the cisplatin-treated rats but was normalized following renal denervation.
  
  
  CONCLUSIONS
  Cisplatin-induced renal injury impaired renal function and caused a sympatho-excitation with blunting of high and low pressure baroreflex regulation of RSNA, which was dependent on the renal innervation. It is suggested that in man with CKD there is a dysregulation of the neural control of the kidney mediated by its sensory innervation.
authors.affiliation: Renal Research Laboratory, Department of Physiology, University College Cork Cork, Ireland.
authors.forename: Niamh E
authors.initials: NE
authors.lastname: Goulding
authors.affiliation: Renal Research Laboratory, Department of Physiology, University College Cork Cork, Ireland.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Johns
keywords: baroreflexes; chronic kidney disease; inflammation; renal innervation; renal sodium excretion