title: Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice.
abstract: Temporomandibular joint (TMJ) osteoarthritis is typically a slowly progressive asymmetric disease. Little is known regarding the natural destruction of TMJ articular tissues. The aim of the present study was to investigate morphological changes in the TMJ of STR/ort mice, known to be the model for spontaneous osteoarthritis in the knee joint, and to evaluate STR/ort mice as a suitable animal model for TMJ osteoarthritis. TMJs from 32 STR/ort mice euthanized at 30, 40, 50 or 60 weeks of age, and from 6 CBA mice euthanized at 30, 40 or 60 weeks of age were examined. Toluidine blue and tartrate-resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using microcomputed tomography. At the age of 40-50 weeks, 17 (68%) of the 25 STR/ort mice had loss of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by microcomputed tomography. The STR/ort mouse strain appears to develop spontaneous osteoarthritis-like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa 230-8501, Japan ; Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Kanagawa 228-0815, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kumagai
authors.affiliation: Section of Biological Science Research Center for Odontology, School of Dentistry, Nippon Dental University, Tokyo 102-8159, Japan.
authors.forename: Satsuki
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Pathology, School of Life Dentistry at Niigata, The Nippon Dental University, Niigata, Niigata 951-8580, Japan.
authors.forename: Yoriaki
authors.initials: Y
authors.lastname: Kanri
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa 230-8501, Japan ; Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Kanagawa 228-0815, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Matsubara
authors.affiliation: Department of Oral and Maxillofacial Surgery, Sagamihara Kyodo Hospital, Sagamihara, Kanagawa 252-0143, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Fujii
authors.affiliation: Department of Oral and Maxillofacial Surgery, Sendai Tokushukai Hospital, Sendai, Miyagi 981-3131, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Wake
authors.affiliation: Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Kanagawa 228-0815, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Suzuki
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa 230-8501, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hamada
keywords: STR/ort mouse; condylar cartilage; microcomputed tomography; osteoarthritis; temporomandibular joint