title: Embryonic-maternal cross-talk via exosomes: potential implications.
abstract: A myriad of locally produced factors into the microenvironment of the reproductive tract is regulated, not one-way but rather, through embryonic-maternal cross-talk. In this mini-review, we focused on the exosomes, which are cell-derived vesicles of 30-100 nm in diameter, as a communicating language facilitating this dialog. These nanovesicles are secreted from pre-implantation embryos, oviduct epithelium, and endometrium as well as from the placenta, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes, and have pleiotropic effects on both embryonic and maternal environments. A better understanding of the molecular mechanisms mediating this cross-talk will lead to the development of new regulating agents, with novel diagnostic, biological, and therapeutic potential for either supporting or hindering the normal reproductive functions.
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Islam M
authors.initials: IM
authors.lastname: Saadeldin
authors.affiliation: Department of Theriogenology and Biotechnology, College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Oh
authors.affiliation: Department of Theriogenology and Biotechnology, College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea ; Institute of Green Bio Science and Technology, Seoul National University, Pyeong Chang, Kangwon do, Republic of Korea.
authors.forename: Byeong Chun
authors.initials: BC
authors.lastname: Lee
keywords: embryo; endometrium; mRNA; miRNA; placenta