title: The therapeutic effect of high-dose esomeprazole on stress ulcer bleeding in trauma patients.
abstract: OBJECTIVE
  To compare the therapeutic effects of different doses of intravenous esomeprazole on treating trauma patients with stress ulcer bleeding.
  
  
  METHODS
  A total of 102 trauma patients with stress ulcer bleeding were randomly divided into 2 groups: 52 patients were assigned to the high-dose group who received 80 mg intravenous esomeprazole, and then 8 mg/h continuous infusion for 3 days; 50 patients were assigned to the conventional dose group who received 40 mg intravenous esomeprazole sodium once every 12 h for 72 h.
  
  
  RESULTS
  Compared with the conventional dose group, the total efficiency of the high-dose group and conventional dose group was 98.08% and 86.00%, respectively (p < 0.05), the hemostatic time was 22.10 h ± 5.18 h and 28.27 h ± 5.96 h, respectively (p < 0.05).
  
  
  CONCLUSIONS
  Both doses of intravenous esomeprazole have good hemostatic effects on stress ulcer bleeding in trauma patients. The high-dose esomeprazole is better for hemostasis.
authors.affiliation: Department of Gastroenterology, Navy General Hospital, Beijing 100048, China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Cui
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Wang
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Yan
authors.forename: Xing
authors.initials: X
authors.lastname: He
authors.forename: San-Dong
authors.initials: SD
authors.lastname: Gong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D064098:Esomeprazole / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*; D013276:Stomach Ulcer / Q000150:complications*; D013315:Stress, Psychological / Q000150:complications*; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D000897:Anti-Ulcer Agents; D064098:Esomeprazole