title: Vasoconstrictive effects of levobupivacaine on the basilar artery in the rabbit.
abstract: BACKGROUND
  Spinal anesthesia is a widely used technique of the modern practice of anesthesia. Spinal cord ischemia is a rare but catastrophic complication of spinal anesthesia which may be caused by a direct vasoconstrictive effect of the local anesthetic. Although the vasoconstrictive effects of levobupivacaine have been widely studied, the vasoconstrictive effects of this drug on the intradural arteries have never been studied. The aim of this study is to evaluate whether levobupivacaine has vasoconstrictive effects on the basilar artery in rabbits.
  
  
  METHODS
  Thirty male New Zealand white rabbits were divided randomly into three groups of ten rabbits each: group 1 (control); group 2 (0.125% levobupivacaine); group 3 (0.25% levobupivacaine). The cisterna magna was punctured as described below, then 1 ml of saline or 0.125% or 0.25% levobupivacaine was injected into the cisterna magna in 10 min by an infusion pump in groups 1, 2 and 3 respectively. All animals were euthanized by perfusion-fixation 30 min after the procedure. The luminal area and the size of the cross-sectional area for each basilar artery were measured.
  
  
  RESULTS
  Both 0.125% and 0.25% levobupivacaine infusion caused significant vasoconstriction. Vasoconstriction was more significant for the 0.125% concentration.
  
  
  CONCLUSIONS
  The results of this study indicated that both 0.125% and 0.25% concentrations of levobupivacaine caused significant vasoconstriction of the basilar artery when administered into the subarachnoid space. This may constitute proof that subarachnoid administration of levobupivacaine may diminish the spinal cord blood flow, causing ischemia.
authors.affiliation: Anesthesiology Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Julide
authors.initials: J
authors.lastname: Ergil
authors.affiliation: Neurosurgery Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Hayri
authors.initials: H
authors.lastname: Kertmen
authors.affiliation: Anesthesiology Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sayın
authors.affiliation: Neurosurgery Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Bora
authors.initials: B
authors.lastname: Gürer
authors.affiliation: Neurosurgery Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Erdal Reşit
authors.initials: ER
authors.lastname: Yılmaz
authors.affiliation: Anesthesiology Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Özkan
authors.affiliation: Department of Pathology, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Ata Türker
authors.initials: AT
authors.lastname: Arıkök
authors.affiliation: National Public Health Agency, Ministry of Health, Ankara, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Kanat
authors.affiliation: Anesthesiology Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Zeki
authors.initials: Z
authors.lastname: Şekerci
keywords: basilar artery; levobupivacaine; subarachnoid; vasoconstriction