title: LAMP3 and TP53 overexpression predicts poor outcome in laryngeal squamous cell carcinoma.
abstract: Lysosomal associated membrane protein 3 (LAMP3) is a newly identified tumor-specific and hypoxia-induced protein. It is a downstream target gene of tumor suppressor TP53 and its expression has been associated with hypoxia-induced metastasis and poor overall survival in cervical, breast and gastrointestinal cancers. However, little is known of LAMP3 protein expression in laryngeal squamous cell carcinoma (LSCC) and its prognostic value. We determined protein expression of LAMP3 and TP53 in LSCC tissues (n=117) by immunohistochemistry analysis on tissue microarray (TMA), their expression was correlated with patients' clinical parameters and overall survival. LAMP3 and TP53 protein expression was significantly higher in cancerous tissues compared to adjacent normal surgical margin tissues. Both high LAMP3 and high TP53 protein expression was significantly associated with tumor stage and size. Significant correlation between LAMP3 and TP53 expression was observed. Patients with high LAMP3 or high TP53 expression had a poor overall survival. Our data suggest that both epithelial LAMP3 expression and TP53 expression are independent prognostic markers for LSCC.
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, Nantong University Affiliated Hospital Jiangsu 226001, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, Nantong University Affiliated Hospital Jiangsu 226001, China.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: You
authors.affiliation: Department of Pathology, Nantong University Affiliated Hospital Jiangsu 226001, China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Laboratory Medicine, Nantong University Affiliated Hospital Jiangsu 226001, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, Nantong University Affiliated Hospital Jiangsu 226001, China.
authors.forename: Huijun
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Nantong University Affiliated Hospital Jiangsu 226001, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Wang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D051907:Lysosomal Membrane Proteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D059666:Lysosomal-Associated Membrane Protein 3
chemical_list: D051907:Lysosomal Membrane Proteins; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53; C114233:LAMP3 protein, human; D059666:Lysosomal-Associated Membrane Protein 3; C495901:TP53 protein, human
keywords: LAMP3; TP53; laryngeal squamous cell carcinoma; prognosis