title: The effectiveness of pulp revascularization in root formation of necrotic immature permanent teeth: A systematic review.
abstract: OBJECTIVE
  The objective of the present study was to carry out a systematic review to analyse the effectiveness of pulp revascularization in the root formation of necrotic immature permanent teeth, as well as the level of scientific evidence regarding this theme.
  
  
  METHODS
  The methodology was based on searching electronic databases such as Web of Science, Pubmed, BVS (Medline, Scielo, Lilacs and BBO), Scopus and Cochrane, including manual searches for the references listed in the studies found. The terms used for the literature search were pulp revascularization and endodontics.
  
  
  RESULTS
  Initially, 277 articles were identified from the electronic databases; 17 studies remained after analysis and exclusion of duplicates; exclusion criteria also eliminated six articles; 11 remained for evaluation.
  
  
  CONCLUSIONS
  Although the results found in the present systematic review are relevant, the scientific evidence should be interpreted with caution as the articles report different methods and evaluation parameters. Despite the capacity of the pulp revascularization technique to stimulate the development of the apical closure and thickening of radicular dentin, several aspects still remain unknown, like the key factors of this repair, the type of tissue formed and the long-term prognosis.
authors.affiliation: a 1 Department of Specific Formation, School of Dentistry, Fluminense Federal University , Nova Friburgo, RJ, Brazil.
authors.forename: Leonardo S
authors.initials: LS
authors.lastname: Antunes
authors.affiliation: b 2 School of Dentistry, Fluminense Federal University , Niterói, RJ, Brazil.
authors.forename: Alessandro G
authors.initials: AG
authors.lastname: Salles
authors.affiliation: a 1 Department of Specific Formation, School of Dentistry, Fluminense Federal University , Nova Friburgo, RJ, Brazil.
authors.forename: Cinthya C
authors.initials: CC
authors.lastname: Gomes
authors.affiliation: c 3 School of Dentistry, Fluminense Federal University , Nova Friburgo, RJ, Brazil.
authors.forename: Thamara B
authors.initials: TB
authors.lastname: Andrade
authors.affiliation: c 3 School of Dentistry, Fluminense Federal University , Nova Friburgo, RJ, Brazil.
authors.forename: Manoela P
authors.initials: MP
authors.lastname: Delmindo
authors.affiliation: a 1 Department of Specific Formation, School of Dentistry, Fluminense Federal University , Nova Friburgo, RJ, Brazil.
authors.forename: Lívia A A
authors.initials: LA
authors.lastname: Antunes
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D056624:Apexification / Q000379:methods*; D001777:Blood Coagulation / Q000502:physiology; D003786:Dental Pulp Cavity / Q000187:drug effects / Q000473:pathology; D003790:Dental Pulp Necrosis / Q000628:therapy*; D006801:Humans; D012038:Regeneration / Q000502:physiology; D012388:Root Canal Irrigants / Q000627:therapeutic use; D019227:Tooth Apex / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D012388:Root Canal Irrigants
keywords: Endodontics; incomplete root formation; pulp revascularization; systematic review