title: The paradoxical role of IL-10 in immunity and cancer.
abstract: Interleukin-10 (IL-10) produced by a wide-variety of cells is a highly pleiotropic cytokine. It has been implicated in the pathogenesis and/or development of autoimmune diseases and cancer, although it displays differential effects that seem to be contradictory sometimes. The ultimate role of this cytokine in disease, however, cannot be fully determined until the immunological contexts that regulate its function are further elucidated. In this review, we will discuss a wide variety of evidence of IL-10 in immunity and cancer in an effort to illuminate the remaining mysteries in the function of this cytokine that, when fully understood, may prove to be a powerful tool in the battle against cancer.
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Mannino
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA 50312, USA; The Affilated Hospital of Xiangnan University, ChenZhou, Hunan 423000, China.
authors.forename: Huaping
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Bai
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wakefield
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA; Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA 50312, USA. Electronic address: yujiang.fang@dmu.edu.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism*; D015551:Autoimmunity; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism*; D053701:Receptors, Interleukin-10 / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D053701:Receptors, Interleukin-10; D016753:Interleukin-10
keywords: Cancer; IL-10; Immune