title: A signal detection theory analysis of behavioral pattern separation paradigms.
abstract: Behavioral pattern separation (BPS) paradigms ask participants to discriminate previously encoded (old) stimuli from highly similar (lure) and categorically distinct (novel) stimuli. The lure-old discrimination, thought to uniquely reflect pattern separation in the hippocampal formation, is typically pitted against the traditional novel-old discrimination. However, BPS paradigms have measured lure-old discrimination neither consistently across studies nor in such a way that allows for accurate comparison to novel-old discrimination. Therefore, we advocate for signal detection theory (SDT) as a unified framework. Moreover, we compare SDT with previously used measures of lure-old discrimination, indicating how other formulas' inaccuracies can lead to erroneous conclusions.
authors.affiliation: Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA rloioti1@jhu.edu.
authors.forename: Rita E
authors.initials: RE
authors.lastname: Loiotile
authors.affiliation: Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21218, USA F. M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, Maryland 21218, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Courtney
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008960:Models, Psychological; D009483:Neuropsychological Tests; D012372:ROC Curve; D021641:Recognition, Psychology; D017603:Signal Detection, Psychological; D055815:Young Adult