title: Epstein-Barr virus-positive inflammatory pseudotumor of the spleen managed with laparoscopic splenectomy.
abstract: We report a case of Epstein-Barr virus (EBV)-positive splenic inflammatory pseudotumor treated by laparoscopic splenectomy. A 66-year-old female without symptoms was found to have a solitary, avascular, solid tumor of the spleen by contrast-enhanced computed tomography. The tumor was compatible with a primary tumor of the spleen. A benign splenic tumor was the most likely diagnosis, but malignant lymphoma could not be ruled out because the serum-soluble interleukin-2 receptor (sIL-2R) level was elevated. Laparoscopic splenectomy was performed to enable a definite diagnosis. Removal of the whole spleen without injury was possible. Possible contamination of the extirpation orifice by cancer cells was carefully prevented by enclosing the spleen in a plastic bag. Histopathological examination showed the tumor to be an EBV-positive inflammatory pseudotumor. To the best of our knowledge, this is only the second report of an EBV-positive splenic inflammatory pseudotumor with an increased serum sIL-2R level. Although EBV-positive inflammatory pseudotumors have been reported to recur, no sign of recurrence has been detected in the present case in the 17 months following splenectomy.
authors.affiliation: Department of Gastroenterological Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan. ise.n@nifty.com.
authors.forename: Norihito
authors.initials: N
authors.lastname: Ise
authors.affiliation: Department of Gastroenterological Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyazawa
authors.affiliation: Department of Gastroenterological Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Satoh
authors.affiliation: Department of Gastroenterological Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
authors.forename: Masatake
authors.initials: M
authors.lastname: Iida
authors.affiliation: Department of Gastroenterological Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchinami
authors.affiliation: Department of Gastroenterological Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kume
authors.affiliation: Department of Gastroenterological Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Yoshioka
authors.affiliation: Department of Clinical Pathology, Akita University School of Medicine, Akita, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nanjo
authors.affiliation: Department of Gastroenterological Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamamoto
keywords: Epstein-Barr virus; Inflammatory pseudotumor; Laparoscopic splenectomy