title: Ninety-Day Subchronic Oral Toxicity Study of Senecio scandens Extract in Rats.
abstract: The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female rats at a single dose of 225, 450, and 900 mg/kg/d. There was no obvious toxicity. Certain changes in hematology and coagulation parameters (red cell distribution width (RDW), platelet count (PLT), monocyte percentage (Mo%), activated partial thromboplastin time (APTT), prothrombin time (PT)) were observed in some administration groups. In regards to the blood biochemical parameters, the levels of creatinine (CRN), potassium, and chloride were increased in a number of the treated rats. There were no significant changes in other hematology, coagulation, or biochemical parameters in rats orally administered S. scandens. S. scandens has a slight effect on rat coagulation and metabolism systems. The herb was safe at all doses tested, but caution should be taken when administering S. scandens at higher doses.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine.
authors.forename: Xiu-Kun
authors.initials: XK
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Yi
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Li
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Wang
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Wang
authors.forename: Zheng-Tao
authors.initials: ZT
authors.lastname: Wang
authors.forename: Zu-Guang
authors.initials: ZG
authors.lastname: Ye
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Liang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D058633:Antipyretics / Q000633:toxicity*; D005260:Female; D008297:Male; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012674:Senecio; D059550:Toxicity Tests, Subchronic
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D010936:Plant Extracts