title: Cardiac Troponin T and Hydration  Status as Prognostic Markers in  Hemodialysis Patients.
abstract: This study aimed to assess cardiac troponin T (cTnT) and hydration state as cardiovascular (CV) risk markers in hemodialysis (HD) patients. Two hundred and forty one patients were divided according to HD vintage into two groups: SV (HD ≤24 months) and LV. Water balance was assessed with overhydration (OH%; bioimpedance analysis) and daily diuresis (DD); CV dysfunction with cTnT and heart ultrasound; nutrition with subjective global assessment (SGA), cholesterol (TC) and albumin. SV had lower OH% (2.8 vs. 3.5, p < 0.05) and higher DD (1,161 vs. 637 ml, p < 0.001), while LV had higher cTnT (0.1 ± 0.04 vs. 0.1 ± 0.07 ng/ml, p < 0.05) and lower interventricular septum thickness (IVS; 13.4 vs. 14.5 mm, p < 0.05). Nutritional state as reflected by lower TC was worse in LV (184.7 vs. 169.5 mg/dl, p < 0.05). Mortality was higher in patients in the LV group (15 vs. 27 deaths, p < 0.05). OH% correlated inversely with albumin (r = -0.36, p < 0.001), TC (r = -0.31, p < 0.001) and cTnT (r = -0.4, p < 0.001). cTnT correlated positively with IVS (r = 0.39, p < 0.001), SGA (r = 0.23, p = 0.001) and mortality rate (r = 0.21, p < 0.01), and negatively with DD (r = -0.34, p < 0.001) and albumin (r = -0.25, p < 0.001). Longer dialysis vintage associates with CV dysfunction, overhydration and increased mortality, which may be predicted with OH% and cTnT. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=376603.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Hoppe
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Schwermer
authors.forename: Patrycja
authors.initials: P
authors.lastname: Klysz
authors.forename: Dorota
authors.initials: D
authors.lastname: Radziszewska
authors.forename: Peter
authors.initials: P
authors.lastname: Sawatiuk
authors.forename: Ewa
authors.initials: E
authors.lastname: Baum
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kaczmarek
authors.forename: Magdalena
authors.initials: M
authors.lastname: Roszak
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Kaluzna
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindholm
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pawlaczyk
authors.forename: Andrzej
authors.initials: A
authors.lastname: Oko
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000401:mortality / Q000628:therapy; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011379:Prognosis; D006435:Renal Dialysis / Q000379:methods* / Q000401:mortality; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D016019:Survival Analysis; D020107:Troponin T / Q000097:blood*; D014882:Water-Electrolyte Balance
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D020107:Troponin T; D002784:Cholesterol