title: The promise and peril of chemical probes.
authors.affiliation: 1] Structural Genomics Consortium, Toronto, Ontario, Canada. [2] Princess Margaret Cancer Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Cheryl H
authors.initials: CH
authors.lastname: Arrowsmith
authors.affiliation: Constellation Pharmaceuticals, Cambridge, Massachusetts, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Audia
authors.affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Austin
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Baell
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, Boston, Massachusetts, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bennett
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.
authors.forename: Julian
authors.initials: J
authors.lastname: Blagg
authors.affiliation: Structural Genomics Consortium, University of Oxford, Oxford, UK.
authors.forename: Chas
authors.initials: C
authors.lastname: Bountra
authors.affiliation: 1] Structural Genomics Consortium, University of Oxford, Oxford, UK. [2] Target Discovery Institute, University of Oxford, Oxford, UK.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Brennan
authors.affiliation: Structural Genomics Consortium, Toronto, Ontario, Canada.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Brown
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer, Cambridge, Massachusetts, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Bunnage
authors.affiliation: GlaxoSmithKline, Collegeville, Pennsylvania, USA.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Buser-Doepner
authors.affiliation: Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Campbell
authors.affiliation: Corporate Department Research Networking, Boehringer Ingelheim GmbH, Ingelheim, Germany.
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Carter
authors.affiliation: The Sir James Black Centre, University of Dundee, Dundee, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Cohen
authors.affiliation: Epizyme, Inc., Cambridge, Massachusetts, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Copeland
authors.affiliation: Department of Chemical Physiology, Scripps Research Institute, San Diego, California, USA.
authors.forename: Ben
authors.initials: B
authors.lastname: Cravatt
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Jayme L
authors.initials: JL
authors.lastname: Dahlin
authors.affiliation: Janssen Research and Development, Spring House, Pennsylvania, USA.
authors.forename: Dashyant
authors.initials: D
authors.lastname: Dhanak
authors.affiliation: Structural Genomics Consortium, Toronto, Ontario, Canada.
authors.forename: Aled M
authors.initials: AM
authors.lastname: Edwards
authors.affiliation: Novartis Institutes for BioMedical Research, Novartis, Basel, Switzerland.
authors.forename: Mathias
authors.initials: M
authors.lastname: Frederiksen
authors.affiliation: Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Frye
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: Nathanael
authors.initials: N
authors.lastname: Gray
authors.affiliation: Takeda California Inc., San Diego, California, USA.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Grimshaw
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer, Cambridge, Massachusetts, USA.
authors.forename: David
authors.initials: D
authors.lastname: Hepworth
authors.affiliation: Janssen Research and Development, High Wycombe, Bucks, UK.
authors.forename: Trevor
authors.initials: T
authors.lastname: Howe
authors.affiliation: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
authors.forename: Kilian V M
authors.initials: KV
authors.lastname: Huber
authors.affiliation: 1] Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [3] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Jin
authors.affiliation: 1] Structural Genomics Consortium, University of Oxford, Oxford, UK. [2] Target Discovery Institute, University of Oxford, Oxford, UK.
authors.forename: Stefan
authors.initials: S
authors.lastname: Knapp
authors.affiliation: Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
authors.forename: Joanne D
authors.initials: JD
authors.lastname: Kotz
authors.affiliation: Cancer Epigenetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
authors.forename: Ryan G
authors.initials: RG
authors.lastname: Kruger
authors.affiliation: Vertex Pharmaceuticals, Boston, Massachusetts, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Lowe
authors.affiliation: Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, USA.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Mader
authors.affiliation: Structural Genomics Consortium, University of Oxford, Oxford, UK.
authors.forename: Brian
authors.initials: B
authors.lastname: Marsden
authors.affiliation: Bayer Pharma AG, Berlin, Germany.
authors.forename: Anke
authors.initials: A
authors.lastname: Mueller-Fahrnow
authors.affiliation: 1] Structural Genomics Consortium, University of Oxford, Oxford, UK. [2] Target Discovery Institute, University of Oxford, Oxford, UK.
authors.forename: Susanne
authors.initials: S
authors.lastname: Müller
authors.affiliation: Oncology Discovery, Merck Research Laboratories, Boston, Massachusetts, USA.
authors.forename: Ronan C
authors.initials: RC
authors.lastname: O'Hagan
authors.affiliation: 1] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK. [2] Stratified Medical, London, UK.
authors.forename: John P
authors.initials: JP
authors.lastname: Overington
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer, Cambridge, Massachusetts, USA.
authors.forename: Dafydd R
authors.initials: DR
authors.lastname: Owen
authors.affiliation: AbbVie, North Chicago, Illinois, USA.
authors.forename: Saul H
authors.initials: SH
authors.lastname: Rosenberg
authors.affiliation: The National Institute of Mental Health Psychoactive Active Drug Screening Program (NIMH PDSP), Department of Pharmacology, The University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Roth
authors.affiliation: UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Roth
authors.affiliation: Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ruth
authors.initials: R
authors.lastname: Ross
authors.affiliation: 1] Structural Genomics Consortium, Toronto, Ontario, Canada. [2] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Schapira
authors.affiliation: Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Schreiber
authors.affiliation: School of Pharmacy, University of California-San Francisco, San Francisco, California, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Shoichet
authors.affiliation: 1] Structural Genomics Consortium, Karolinska Institutet, Solna, Sweden. [2] Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Sundström
authors.affiliation: 1] CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. [2] Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
authors.forename: Giulio
authors.initials: G
authors.lastname: Superti-Furga
authors.affiliation: 1] Department of Cellular and Molecular Pharmacology, University of California-San Francisco, San Francisco, California, USA. [2] Howard Hughes Medical Institute, University of California-San Francisco, San Francisco, California, USA.
authors.forename: Jack
authors.initials: J
authors.lastname: Taunton
authors.affiliation: CHDI Management/CHDI Foundation, Los Angeles, California, USA.
authors.forename: Leticia
authors.initials: L
authors.lastname: Toledo-Sherman
authors.affiliation: Structural Genomics Consortium, McGill University, Montreal, Quebec, Canada.
authors.forename: Chris
authors.initials: C
authors.lastname: Walpole
authors.affiliation: University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Walters
authors.affiliation: 1] UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Structural Genomics Consortium, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Willson
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Workman
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Young
authors.affiliation: 1] UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Structural Genomics Consortium, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Zuercher
mesh_terms: D035843:Biomedical Research / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D033181:Information Dissemination / Q000941:ethics*; D018973:Intellectual Property; D020407:Internet; D015335:Molecular Probes / Q000737:chemistry* / Q000494:pharmacology; D008970:Molecular Weight; D012680:Sensitivity and Specificity; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D015335:Molecular Probes; D054852:Small Molecule Libraries