title: Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice.
abstract: Pregnant women who are obese or have gestational diabetes mellitus have elevated leptin levels and their children have an increased risk for child and adult obesity. The goals of this study were to determine whether offspring weights are altered by maternal hyperleptinemia, and whether this occurs via behavioral changes that influence energy balance. We used 2 hyperleptinemic mouse models. The first was females heterozygous for a leptin receptor mutation (DB/+), which were severely hyperleptinemic, and that were compared with wild-type females. The second model was wild-type females infused with leptin (LEP), which were moderately hyperleptinemic, and were compared with wild-type females infused with saline (SAL). Total food consumption, food preference, locomotor activity, coordinated motor skills, and anxiety-like behaviors were assessed in wild-type offspring from each maternal group at 3 postnatal ages: 4-6, 11-13, and 19-21 weeks. Half the offspring from each group were then placed on a high-fat diet, and behaviors were reassessed. Adult offspring from both groups of hyperleptinemic dams weighed less than their respective controls beginning at 23 weeks of age, independent of diet or sex. Weight differences were not explained by food consumption or preference, because female offspring from hyperleptinemic dams tended to consume more food and had reduced preference for palatable, high-fat and sugar, food compared with controls. Offspring from DB/+ dams were more active than offspring of controls, as were female offspring of LEP dams. Maternal hyperleptinemia during pregnancy did not predispose offspring to obesity, and in fact, reduced weight gain.
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health (K.E.P., K.A.P., L.C.S.), University of Missouri, Columbia, Missouri 65212; Department of Animal Sciences (K.E.P., M.R.E., L.C.S.), University of Missouri, Columbia, Missouri 65211; Department of Health Sciences (D.S.), University of Missouri, Columbia, Missouri 65212; School of Medicine (R.T.), University of Missouri, Columbia, Missouri 65212; Division of Biological Sciences (J.K., L.C.S.), University of Missouri, Columbia, Missouri 65211; and Department of Psychological Sciences (D.K.M.), University of Missouri, Columbia, Missouri 65211.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Pollock
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health (K.E.P., K.A.P., L.C.S.), University of Missouri, Columbia, Missouri 65212; Department of Animal Sciences (K.E.P., M.R.E., L.C.S.), University of Missouri, Columbia, Missouri 65211; Department of Health Sciences (D.S.), University of Missouri, Columbia, Missouri 65212; School of Medicine (R.T.), University of Missouri, Columbia, Missouri 65212; Division of Biological Sciences (J.K., L.C.S.), University of Missouri, Columbia, Missouri 65211; and Department of Psychological Sciences (D.K.M.), University of Missouri, Columbia, Missouri 65211.
authors.forename: Damaiyah
authors.initials: D
authors.lastname: Stevens
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health (K.E.P., K.A.P., L.C.S.), University of Missouri, Columbia, Missouri 65212; Department of Animal Sciences (K.E.P., M.R.E., L.C.S.), University of Missouri, Columbia, Missouri 65211; Department of Health Sciences (D.S.), University of Missouri, Columbia, Missouri 65212; School of Medicine (R.T.), University of Missouri, Columbia, Missouri 65212; Division of Biological Sciences (J.K., L.C.S.), University of Missouri, Columbia, Missouri 65211; and Department of Psychological Sciences (D.K.M.), University of Missouri, Columbia, Missouri 65211.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Pennington
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health (K.E.P., K.A.P., L.C.S.), University of Missouri, Columbia, Missouri 65212; Department of Animal Sciences (K.E.P., M.R.E., L.C.S.), University of Missouri, Columbia, Missouri 65211; Department of Health Sciences (D.S.), University of Missouri, Columbia, Missouri 65212; School of Medicine (R.T.), University of Missouri, Columbia, Missouri 65212; Division of Biological Sciences (J.K., L.C.S.), University of Missouri, Columbia, Missouri 65211; and Department of Psychological Sciences (D.K.M.), University of Missouri, Columbia, Missouri 65211.
authors.forename: Rose
authors.initials: R
authors.lastname: Thaisrivongs
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health (K.E.P., K.A.P., L.C.S.), University of Missouri, Columbia, Missouri 65212; Department of Animal Sciences (K.E.P., M.R.E., L.C.S.), University of Missouri, Columbia, Missouri 65211; Department of Health Sciences (D.S.), University of Missouri, Columbia, Missouri 65212; School of Medicine (R.T.), University of Missouri, Columbia, Missouri 65212; Division of Biological Sciences (J.K., L.C.S.), University of Missouri, Columbia, Missouri 65211; and Department of Psychological Sciences (D.K.M.), University of Missouri, Columbia, Missouri 65211.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kaiser
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health (K.E.P., K.A.P., L.C.S.), University of Missouri, Columbia, Missouri 65212; Department of Animal Sciences (K.E.P., M.R.E., L.C.S.), University of Missouri, Columbia, Missouri 65211; Department of Health Sciences (D.S.), University of Missouri, Columbia, Missouri 65212; School of Medicine (R.T.), University of Missouri, Columbia, Missouri 65212; Division of Biological Sciences (J.K., L.C.S.), University of Missouri, Columbia, Missouri 65211; and Department of Psychological Sciences (D.K.M.), University of Missouri, Columbia, Missouri 65211.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Ellersieck
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health (K.E.P., K.A.P., L.C.S.), University of Missouri, Columbia, Missouri 65212; Department of Animal Sciences (K.E.P., M.R.E., L.C.S.), University of Missouri, Columbia, Missouri 65211; Department of Health Sciences (D.S.), University of Missouri, Columbia, Missouri 65212; School of Medicine (R.T.), University of Missouri, Columbia, Missouri 65212; Division of Biological Sciences (J.K., L.C.S.), University of Missouri, Columbia, Missouri 65211; and Department of Psychological Sciences (D.K.M.), University of Missouri, Columbia, Missouri 65211.
authors.forename: Dennis K
authors.initials: DK
authors.lastname: Miller
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health (K.E.P., K.A.P., L.C.S.), University of Missouri, Columbia, Missouri 65212; Department of Animal Sciences (K.E.P., M.R.E., L.C.S.), University of Missouri, Columbia, Missouri 65211; Department of Health Sciences (D.S.), University of Missouri, Columbia, Missouri 65212; School of Medicine (R.T.), University of Missouri, Columbia, Missouri 65212; Division of Biological Sciences (J.K., L.C.S.), University of Missouri, Columbia, Missouri 65211; and Department of Psychological Sciences (D.K.M.), University of Missouri, Columbia, Missouri 65211.
authors.forename: Laura Clamon
authors.initials: LC
authors.lastname: Schulz
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D059305:Diet, High-Fat; D004435:Eating / Q000187:drug effects / Q000235:genetics; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D015870:Gene Expression; D020738:Leptin / Q000097:blood* / Q000494:pharmacology; D008297:Male; D008659:Metabolic Diseases / Q000097:blood / Q000503:physiopathology; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D009765:Obesity / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000503:physiopathology*; D054411:Receptors, Leptin / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors
chemical_list: D020738:Leptin; D054411:Receptors, Leptin