title: Clinical and Histological Features of Small Cell Lung Cancer Paraneoplastic Inflammatory Uveitis.
abstract: OBJECTIVE
  Paraneoplastic ocular inflammation can be associated with the autoantibody against collapsin response-mediator protein-5 (anti-CRMP-5). We describe the clinical and histological features of 2 rare cases of small cell lung carcinoma (SCLC) presenting with intraocular inflammation: the first was anti-CRMP-5 positive and the second preceded the auto-antibody's discovery but with remarkably similar features. The previously unreported retinal histology is described.
  
  
  METHODS
  Case notes review.
  
  
  RESULTS
  Both cases presented with bilateral visual loss, constricted visual fields, vitritis, and pale, swollen optic discs. Fundal fluorescein angiographies showed optic disc leakage. Retinal histology of both cases revealed predominantly inner retinal inflammation. Following their diagnosis with SCLC, serology for case 1 was positive for anti-CRMP-5 but case 2 pre-dated its discovery.
  
  
  CONCLUSIONS
  CRMP-5 inflammatory eye disease presents with a distinct pattern of clinical and histological features, which may be the first sign of their underlying cancer. Retinal histology revealed predominantly inner retinal inflammation.
authors.affiliation: a Western Eye Hospital , London , UK .
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Casswell
authors.affiliation: b Kings College Hospital , London , UK .
authors.forename: Edward
authors.initials: E
authors.lastname: Pringle
authors.affiliation: c Department of Ocular Biology and Therapeutics , UCL Institute of Ophthalmology , London , UK .
authors.forename: Caroline
authors.initials: C
authors.lastname: Thuang
authors.affiliation: d National Hospital of Neurology & Neurosurgery, Queen's Square , London , UK , and.
authors.forename: Mike D
authors.initials: MD
authors.lastname: Sanders
authors.affiliation: e St Thomas' Hospital , London , UK.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Graham
mesh_terms: D001323:Autoantibodies / Q000097:blood; D018288:Carcinoma, Small Cell / Q000276:immunology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D006867:Hydrolases; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology*; D008297:Male; D008869:Microtubule-Associated Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000276:immunology / Q000473:pathology*; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000276:immunology / Q000473:pathology*
chemical_list: D001323:Autoantibodies; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C415087:DPYSL5 protein, human; D006867:Hydrolases
keywords: CRMP-5; histology; inflammation; paraneoplastic; visual loss