title: Neonatal lupus erythematosus: a review of 123 cases in China.
abstract: OBJECTIVE
  To analyze the clinical features, outcomes and prognosis of neonatal lupus erythematosus (NLE) in China.
  
  
  METHODS
  We reviewed 12 NLE cases at the Peking Union Medical College Hospital and compared the data with 111 cases reported in China between 1990 and 2014. The Chinese medical journal search engines used in this study were Wanfang.data and Science China.
  
  
  RESULTS
  No gender dominance in NLE incidence was found. Cutaneous lesions were present in more than 96% of patients, while cardiac, hematological and hepatobiliary manifestations were seen in 12.61%, 45.53% and 17.89% of cases, respectively. Congenital heart block (CHB) tended to be more persistent, with two cases showing CHB for 1 year and three cases persisting for 7-10 years. In this study more than 90% of mothers were anti-Sjögren's syndrome A positive, and 65.04% were asymptomatic prior to the pregnancy.
  
  
  CONCLUSIONS
  These results indicate that clinicians, especially dermatologists, in China should improve their recognition of this disease to avoid misdiagnosis, and more attention should be paid to the follow-up of NLE patients and their asymptomatic mothers.
authors.affiliation: Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: Li
authors.affiliation: Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, West China Hospital, Sichuan University, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D008297:Male; D000068097:Maternal Health; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers
keywords: anti-Sjogren's syndrome antigen/B antibodies; congenital heart block; neonatal lupus erythematosus