title: Pd-Catalyzed C(sp(3))-H Carbonylation of Alkylamines: A Powerful Route to γ-Lactams and γ-Amino Acids.
abstract: A novel Pd-catalyzed direct C(sp(3))-H carbonylation of alkylamines for the synthesis of γ-lactams and γ-amino acids has been developed, in which TEMPO was used as the crucial sole oxidant. The synthetic prospect was demonstrated by the concise total synthesis of rac-Pregbalin.
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Pei-Long
authors.initials: PL
authors.lastname: Wang
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Lan
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.|‡Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Shanghai, 200032, China.
authors.forename: Xi-Sheng
authors.initials: XS
authors.lastname: Wang
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D000069583:Pregabalin / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007769:Lactams; D000069583:Pregabalin; D010165:Palladium