title: Malignant Eccrine Spiradenoma of the Face.
abstract: Malignant eccrine spiradenoma, or spiradenocarcinoma, is an exceedingly rare sweat-gland tumor, with only 102 reported cases. Low-grade carcinomas are especially rare with only a few cases reported. Because of the limited number of case reports, the biologic behavior of low-grade malignant eccrine spiradenoma is poorly understood and no evidence-based therapeutic approach is established. Here, the authors report a 29-year-old woman who presented with a history of left-sided facial lesions present since the age of 2 months. Histopathologic examination revealed multiple benign spiradenomas, several of which showed foci of low-grade malignant transformation evidenced by loss of the characteristic 2-cell population seen in the benign tumor component. Included are the clinical presentation, histopathologic description, and surgical decision making in an effort to guide recognition of this rare entity.
authors.affiliation: *Division of Plastic Surgery †Division of Dermatopathology, Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
authors.forename: Theodore T
authors.initials: TT
authors.lastname: Nyame
authors.forename: David
authors.initials: D
authors.lastname: Mattos
authors.forename: Christine G
authors.initials: CG
authors.lastname: Lian
authors.forename: Scott R
authors.initials: SR
authors.lastname: Granter
authors.forename: Alvaro C
authors.initials: AC
authors.lastname: Laga
authors.forename: E J
authors.initials: EJ
authors.lastname: Caterson
mesh_terms: D006607:Adenoma, Sweat Gland / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003937:Diagnosis, Differential; D005153:Facial Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology; D054079:Vascular Malformations / Q000175:diagnosis