title: Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor.
abstract: The as-yet unidentified E. coli metabolite colibactin induces DNA damage in eukaryotic cells and promotes tumorigenesis. Its wide distribution in pathogenic and probiotic strains has raised great interest in its structure and biosynthesis. Here we show that colibactin formation involves a rare aminomalonyl unit used as a building block.
authors.affiliation: Institute of Microbiology, Eigenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland. jpiel@ethz.ch.
authors.forename: A O
authors.initials: AO
authors.lastname: Brachmann
authors.forename: C
authors.initials: C
authors.lastname: Garcie
authors.forename: V
authors.initials: V
authors.lastname: Wu
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: R
authors.initials: R
authors.lastname: Ueoka
authors.forename: E
authors.initials: E
authors.lastname: Oswald
authors.forename: J
authors.initials: J
authors.lastname: Piel
mesh_terms: D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D061065:Polyketides / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D010455:Peptides; D061065:Polyketides; C569566:colibactin