title: Localized laryngeal amyloidosis - a case report.
abstract: Amyloidosis encompasses a variety of conditions, caused by extracellular, insoluble protein fibrils that disturb the normal functioning of cells and organs. The disease may be localized or systemic, hereditary or acquired (associated with chronic inflammatory or hematological diseases). We present the case of a 49-year-old woman, with symptoms including dysphagia, dysphonia and dyspnea. After taking the case history and performing clinical examination, we suspected a laryngeal tumor to be the cause of the symptoms. Microlaryngoscopy and biopsy were performed. The histopathological examination result of the biopsy specimen was amyloidosis. Surgical excision of the tumor was performed. Our case presentation describes this rare pathological finding, its clinical manifestations, the histopathological and surgical diagnostic problems, treatment, patient evolution and the difficulties we encountered along the way, through the scope of our personal experience.
authors.affiliation: Department of Otolaryngology, University of Medicine and Pharmacy of Tirgu Mures, Romania; ghe.muhlfay@gmail.com.
authors.forename: Mihály
authors.initials: M
authors.lastname: Szőcs
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Mühlfay
authors.forename: Simona Liliana
authors.initials: SL
authors.lastname: Mocan
authors.forename: Andor
authors.initials: A
authors.lastname: Balázs
authors.forename: Radu Mircea
authors.initials: RM
authors.lastname: Neagoe
mesh_terms: D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D007828:Laryngoscopy; D008875:Middle Aged; D014057:Tomography, X-Ray Computed