title: New naphthopyrones from marine-derived fungus Aspergillus niger 2HL-M-8 and their in vitro antiproliferative activity.
abstract: A new cytotoxic dimeric naphthopyrone, aurasperone H (1), together with eight related known polyketides (2-9) was isolated from a marine-derived fungus Aspergillus niger 2HL-M-8. The structure of new compound 1 was elucidated on the basis of its spectroscopic data (1D, 2D NMR and CD). Compound 1 exhibited moderate inhibitory activity against the human lung adenocarcinoma A549 and the human leukaemia HL-60 cell lines. Compound 5 displayed significant in vitro antiproliferative activity against HL-60 cell line with an IC50 value of 0.8 μM.
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Da-Hong
authors.initials: DH
authors.lastname: Li
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Tong
authors.initials: T
authors.lastname: Han
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Guan
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Zhan-Lin
authors.initials: ZL
authors.lastname: Li
authors.affiliation: b School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.affiliation: a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001234:Aspergillus niger / Q000737:chemistry*; D045744:Cell Line, Tumor / Q000187:drug effects; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D015394:Molecular Structure; D009281:Naphthalenes / Q000302:isolation & purification / Q000494:pharmacology*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009281:Naphthalenes; D061065:Polyketides; D011753:Pyrones; C000611767:aurasperone H; C432445:naphthopyrone dimer
keywords: Aspergillus niger; antiproliferative activity; dimeric naphthopyrones