title: A patient with esophageal cancer with bone metastasis who achieved pain relief with repetitive administration of strontium-89 chloride.
abstract: A 75-year-old woman was diagnosed with esophageal cancer with difficulty in swallowing. She had a past history of rheumatoid arthritis, scleroderma, interstitial pneumonia, angina pectoris (with coronary artery bypass surgery) and arrhythmia (with pacemaker implantation). She refused surgery, and chemotherapy and radiotherapy were not performed because of the high risk accompanied with multiple comorbidities. She received proton therapy at another hospital and the primary lesion shrank. Bone metastasis in the thoracic vertebrae was diagnosed 10 months after diagnosis of esophageal cancer. Non-steroidal anti-inflammatory drugs and zoledronic acid were administered for back pain. Oxycodone was also administered but discontinued due to nausea. After strontium-89 ((89)Sr) chloride administration, her back pain was relieved. (89)Sr was administered five times every 3 months, and the pain did not worsen until her death due to pneumonia 2 years after diagnosis of esophageal cancer. (89)Sr was effective for pain from bone metastasis of esophageal cancer, and its repeated administration was safe.
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan, maeda-o@med.nagoya-u.ac.jp.
authors.forename: Osamu
authors.initials: O
authors.lastname: Maeda
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ando
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ishiguro
authors.forename: Osamu
authors.initials: O
authors.lastname: Watanabe
authors.forename: Ryoji
authors.initials: R
authors.lastname: Miyahara
authors.forename: Masanao
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kohei
authors.initials: K
authors.lastname: Funasaka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Furukawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ando
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kato
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary*; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D059408:Pain Management / Q000379:methods*; D012074:Remission Induction; D013324:Strontium / Q000008:administration & dosage*
chemical_list: C025700:strontium chloride; D013324:Strontium