title: Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1.
abstract: Zearalenone (ZEN) and its derivative, zearalanone (ZAN), are endocrine disruptive mycotoxins produced by Fusarium species. We investigated the human placental metabolism of ZEN and ZAN in vitro in JEG-3 cells, human term placental subcellular fractions and recombinant enzymes. Human placental enzymes were capable of metabolizing ZEN and ZAN to their primary OH-metabolites which have higher affinity for estrogen receptors than their parent compounds. These metabolites may interfere with physiological placental estrogen signaling and thus disrupt the progress of gestation.
authors.affiliation: School of Pharmacy, University of Eastern Finland, FIN-70211 Kuopio, Finland. Electronic address: pasi.huuskonen@uef.fi.
authors.forename: Pasi
authors.initials: P
authors.lastname: Huuskonen
authors.affiliation: School of Pharmacy, University of Eastern Finland, FIN-70211 Kuopio, Finland.
authors.forename: Seppo
authors.initials: S
authors.lastname: Auriola
authors.affiliation: School of Pharmacy, University of Eastern Finland, FIN-70211 Kuopio, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Pasanen
mesh_terms: D001141:Aromatase / Q000378:metabolism*; D045744:Cell Line, Tumor; D052244:Endocrine Disruptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011994:Recombinant Proteins; D015025:Zearalenone / Q000378:metabolism*
chemical_list: D052244:Endocrine Disruptors; D011994:Recombinant Proteins; D015025:Zearalenone; D001141:Aromatase; C561410:CYP19A1 protein, human
keywords: CYP19A1; Endocrine disruptor; JEG-3; Placenta; Zearalanone; Zearalenone