title: Cascade bicyclizations of o-alkynyl aldehydes with thiazolium salts: a new access toward poly-functionalized indeno[2,1-b]pyrroles.
abstract: A new cascade bicyclization of o-alkynyl aldehydes with thiazolium salts is described, in which 25 examples of densely functionalized indeno[2,1-b]pyrroles are achieved in a functional-group-compatible manner. Thiazole carbenes generated in situ from thiazolium salts play dual roles as reaction partners and as NHC catalysts. The synthetic utility of these bicyclization reactions results in subsequent C-C bond-forming events to rapidly build up molecular complexity.
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, 211116, P. R. China. wjhao@jsnu.edu.cn jiangchem@jsnu.edu.cn laotu@jsnu.edu.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Hao
authors.forename: Jin-Peng
authors.initials: JP
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D012492:Salts / Q000138:chemical synthesis / Q000737:chemistry; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D007192:Indenes; D011758:Pyrroles; D012492:Salts; D013844:Thiazoles; C030011:carbene; D008697:Methane