title: Divergence of Vascular Specification in Visceral Lymphoid Organs-Genetic Determinants and Differentiation Checkpoints.
abstract: Despite their functional similarities, peripheral lymphoid tissues are remarkably different according to their developmental properties and structural characteristics, including their specified vasculature. Access of leukocytes to these organs critically depends on their interactions with the local endothelium, where endothelial cells are patterned to display a restricted set of adhesion molecules and other regulatory compounds necessary for extravasation. Recent advances in high throughput analyses of highly purified endothelial subsets in various lymphoid tissues as well as the expansion of various transgenic animal models have shed new light on the transcriptional complexities of lymphoid tissue vascular endothelium. This review is aimed at providing a comprehensive analysis linking the functional competence of spleen and intestinal lymphoid tissues with the developmental programming and functional divergence of their vascular specification, with particular emphasis on the transcriptional control of endothelial cells exerted by Nkx2.3 homeodomain transcription factor.
authors.affiliation: a Department of Immunology and Biotechnology.|b Lymphoid Organogenesis Research Group Szentágothai Research Center, University of Pécs , Pécs , Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Kellermayer
authors.affiliation: c Laboratory of Immunoregulation, Osaka University Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University , Osaka , Japan.
authors.forename: Haruko
authors.initials: H
authors.lastname: Hayasaka
authors.affiliation: d Department of Pathology , University of Pécs , Pécs , Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Kajtár
authors.affiliation: a Department of Immunology and Biotechnology.
authors.forename: Diána
authors.initials: D
authors.lastname: Simon
authors.affiliation: e Centro de Investigación Médica Aplicada of the University of Navarra , Pamplona , Spain.
authors.forename: Eloy F
authors.initials: EF
authors.lastname: Robles
authors.affiliation: e Centro de Investigación Médica Aplicada of the University of Navarra , Pamplona , Spain.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Martinez-Climent
authors.affiliation: a Department of Immunology and Biotechnology.|b Lymphoid Organogenesis Research Group Szentágothai Research Center, University of Pécs , Pécs , Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Balogh
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002454:Cell Differentiation / Q000276:immunology*; D042783:Endothelial Cells / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D005786:Gene Expression Regulation / Q000276:immunology*; D059014:High-Throughput Nucleotide Sequencing; D018398:Homeodomain Proteins / Q000235:genetics / Q000276:immunology; D006801:Humans; D007422:Intestines / Q000098:blood supply / Q000196:embryology / Q000502:physiology; D007962:Leukocytes / Q000276:immunology; D008221:Lymphoid Tissue / Q000098:blood supply* / Q000196:embryology / Q000502:physiology*; D051379:Mice; D038081:Organogenesis; D010581:Peyer's Patches / Q000098:blood supply / Q000196:embryology / Q000502:physiology; D017423:Sequence Analysis, RNA; D013154:Spleen / Q000098:blood supply / Q000196:embryology / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology
chemical_list: D018398:Homeodomain Proteins; C534957:NKX2-3 protein, human; C522706:Nkx2.3 protein, mouse; D014157:Transcription Factors
keywords: Endothelium; Nkx2.3; Peyer patches; patterning; spleen