title: Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag.
abstract: Severe refractory ITP is clinically challenging and a variety of single or combination chemotherapies have been tried with limited outcome. We report a case of ITP that was unresponsive to multiple agents including high-dose steroid, IVIG, Rho(D) immune globulin, rituximab, cyclosporine, azathioprine, vincristine, mycophenolate mofetil, romiplostim, and eltrombopag; however, it achieved complete remission with combination treatment of cyclophosphamide and eltrombopag.
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ 86721, USA.
authors.forename: Faiz
authors.initials: F
authors.lastname: Anwer
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ 86721, USA.
authors.forename: Seongseok
authors.initials: S
authors.lastname: Yun
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ 86721, USA.
authors.forename: Anju
authors.initials: A
authors.lastname: Nair
authors.affiliation: Medical Oncology, Arizona Oncology Associates, Tucson, AZ 85704, USA.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ahmad
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ 86721, USA.
authors.forename: Ravitharan
authors.initials: R
authors.lastname: Krishnadashan
authors.affiliation: Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA.
authors.forename: H Joachim
authors.initials: HJ
authors.lastname: Deeg