title: Hematological Parameters as Predictors of Cardiovascular Disease in Obstructive Sleep Apnea Syndrome Patients.
abstract: We investigated the role of the red cell distribution width (RDW) and other parameters including platelet (PLT) count, mean platelet volume (MPV), and platelet distribution width (PDW) in patients with obstructive sleep apnea syndrome (OSAS) having cardiovascular diseases (CVDs). Patients (n = 142) having sleep disorders and who applied for a night polysomnography were included in this study. For statistical analysis, chi-square test, bivarite correlation, and logistic and stepwise regression tests were used. A positive correlation between RDW MPV, RDW, and body mass index as well as PLT and apnea-hypopnea index were observed. A negative correlation between AHI and PDW (P= .041) and a positive correlation between AHI and PLT (P= .010) were found in the patients ≥40 years old with CVD. The RDW was higher in patients ≥40 years old who had CVD (P= .016), and 19% of them had RDW >14%. The PDW (odds ratio = 6.02 [95% confidence interval = 1.3-28.2],P= .023) appeared to be associated with increased risk of hyperlipidemia in patients with severe OSAS. If these results are confirmed, RDW could be used with other markers, especially PLT and PDW, in prediction of CVD in patients with severe OSAS.
authors.affiliation: Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey Center for Sleep Sciences and Medicine, Suleyman Demirel University, Isparta, Turkey fizyolog@gmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Saygin
authors.affiliation: Center for Sleep Sciences and Medicine, Suleyman Demirel University, Isparta, Turkey Department of Chest Diseases, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Onder
authors.initials: O
authors.lastname: Ozturk
authors.affiliation: Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey Center for Sleep Sciences and Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Mehmet Fehmi
authors.initials: MF
authors.lastname: Ozguner
authors.affiliation: Center for Sleep Sciences and Medicine, Suleyman Demirel University, Isparta, Turkey Department of Chest Diseases, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akkaya
authors.affiliation: Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004909:Erythrocyte Indices / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods; D008875:Middle Aged; D010976:Platelet Count / Q000379:methods; D017286:Polysomnography / Q000379:methods; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis
chemical_list: D015415:Biomarkers
keywords: cardiovascular diseases; mean platelet volume; obstructive sleep apnea syndrome; platelet count; platelet distribution width; red cell distribution width