title: Effect of statins on preventing infectious complications after surgery: Systematic review and meta-analysis.
abstract: OBJECTIVE
  *These authors contributed equally to this work.A meta-analysis to investigate the association between preoperative statin use and the risk of postoperative infectious complications in patients undergoing surgery.
  
  
  METHODS
  PubMed(®) and Embase(®) databases were searched for relevant studies. Data were extracted using a standardized data collection form. The primary effect measure was the odds ratio (OR) of postoperative infectious complications. Summary OR were calculated.
  
  
  RESULTS
  The analysis included 10 cohort studies with a total of 147 263 participants. Statin use was associated with a lower incidence of postoperative infectious complications in all studies (summary OR 0.917, 95% conﬁdence intervals [CI] 0.862, 0.975, fixed-effects model; summary OR 0.731, 95% CI 0.584, 0.870, random-effects model); cardiac surgery (summary OR 0.673; 95% CI 0.535, 0.847); treatment in the USA (summary OR 0.678; 95% CI 0.597, 0.770); retrospective cohort studies (summary OR 0.664; 95% CI 0.521, 0.846).
  
  
  CONCLUSIONS
  Preoperative statin use is associated with a reduced risk of postoperative infectious complications.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Binzhou Medical University, Binzhou, China sfdbh2006@sohu.com.
authors.forename: Bao-Xin
authors.initials: BX
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Affiliated Hospital of Binzhou Medical University, Binzhou, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Cardiology, Affiliated Hospital of Binzhou Medical University, Binzhou, China.
authors.forename: Jing-Sen
authors.initials: JS
authors.lastname: Li
authors.affiliation: Department of Geriatrics, First Hospital of Jilin University, Changchun, China.
authors.forename: Sui-Sheng
authors.initials: SS
authors.lastname: Wu
mesh_terms: D003141:Communicable Diseases / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology*; D011300:Preoperative Care
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Statin; postoperative infection; surgery