title: Synthesis of new 5-((2-(substituted phenoxymethyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazole-2-thiol: A novel class of potential antibacterial and antifungal agents.
abstract: Novel 1,3,4-Oxadiazoles bearing benzimidazole nucleus were designed, synthesized using 2-(2-(substituted phenoxymethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide and carbon disulfide. These newly synthesized benzimidazolyl oxadiazoles along with benzimidazolyl acetates and benzimidazolyl acetohydrazides were screened for their antibacterial activity against two kinds of strains using the agar disk diffusion method and antifungal activity against Aspergillus niger and Ustilago maydis. The results showed that some of the compounds exhibited moderate activity against both the strains in antibacterial activity and majority of compounds are not active in antifungal activity. The structure-activity relationships were briefly discussed. The studies indicated that compounds of Benzimidazolyl acetohydrazide were the most potent inhibitors compared to the other compounds under investigation.
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515 003, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Manjunath
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515 003, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Bheemaraju
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515 003, Andhra Pradesh, India.
authors.forename: M
authors.initials: M
authors.lastname: Mahesh
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515 003, Andhra Pradesh, India. Electronic address: ramanapv54@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Venkata Ramana
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001562:Benzimidazoles; D007093:Imidazoles; D010069:Oxadiazoles; D013438:Sulfhydryl Compounds; C583463:1,3,4-oxadiazole
keywords: Activité antibactérienne; Activité antifongique; Antibacterial activity; Antifungal activity; Cresol; Crésol; Imidazole; L’o-phénylènediamine; O-phenylenediamine; Oxadiazole