title: Toward Intraoperative Breast Endomicroscopy With a Novel Surface-Scanning Device.
abstract: New optical biopsy methods such as confocal endomicroscopy represent a promising tool for breast conserving surgery, allowing real-time assessment of tumor margins. However, it remains difficult to scan over a large surface area because of the small field-of-view. This paper presents a novel robotic instrument to perform automated scanning with a fiber bundle endomicroscope probe to expand the effective imaging area. The device uses a rigid concentric tube scanning mechanism to facilitate large-area mosaicking. It has a compact design with a diameter of 6 mm, incorporating a central channel with a diameter of 3 mm for passing through a fiber bundle probe. A bespoke bearing, an inflated balloon, and a passive linear structure are used to control image rotation and ensure consistent tool-tissue contact. Experimental results show that the device is able to scan a spiral trajectory over a large hemispherical surface. Detailed performance evaluation was performed and the bending angle ranges from -90° to 90° with high repeatability and minimal rotational hysteresis errors. The device has also been validated with breast phantom and ex vivo human breast tissue, demonstrating the potential clinical value of the system.
authors.forename: Siyang
authors.initials: S
authors.lastname: Zuo
authors.forename: Michael
authors.initials: M
authors.lastname: Hughes
authors.forename: Carlo
authors.initials: C
authors.lastname: Seneci
authors.forename: Tou Pin
authors.initials: TP
authors.lastname: Chang
authors.forename: Guang-Zhong
authors.initials: GZ
authors.lastname: Yang
mesh_terms: D000465:Algorithms; D001940:Breast / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery; D004867:Equipment Design; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D015412:Mastectomy, Segmental / Q000295:instrumentation* / Q000379:methods; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods; D019047:Phantoms, Imaging; D065287:Robotic Surgical Procedures / Q000295:instrumentation* / Q000379:methods