title: Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women.
abstract: BACKGROUND
  Betatrophin is produced primarily by liver and adipose tissue and has been recently reported as a novel hormone promoting β-cell proliferation and β-cell mass and improving glucose tolerance.
  
  
  OBJECTIVE
  Because it is markedly regulated by nutritional status, we hypothesized that circulating betatrophin levels might be affected by pathophysiological conditions altering body weight.
  
  
  METHODS
  We analyzed circulating betatrophin levels in 149 female patients, including 99 with extreme body mass index (30 anorexia nervosa, 24 obese, 45 morbid obese, and 50 healthy eating/weight controls).
  
  
  METHODS
  Serum betatrophin levels and its correlations with different anthropometric and biochemical parameters were measured.
  
  
  RESULTS
  Plasma betatrophin levels were significantly elevated in anorexic patients, whereas its levels were reduced in morbidly obese women when compared with normal-weight women. Plasma betatrophin correlated negatively with weight, body mass index, fat percentage, glucose, insulin, and homeostatic model assessment index and positively correlated with high-density lipoprotein.
  
  
  CONCLUSIONS
  These results suggest that metabolic status is an important regulator of circulating betatrophin levels.
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Silvia
authors.initials: S
authors.lastname: Barja-Fernández
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Cintia
authors.initials: C
authors.lastname: Folgueira
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Luisa M
authors.initials: LM
authors.lastname: Seoane
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Felipe F
authors.initials: FF
authors.lastname: Casanueva
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Carlos
authors.initials: C
authors.lastname: Dieguez
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Cecilia
authors.initials: C
authors.lastname: Castelao
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Zaida
authors.initials: Z
authors.lastname: Agüera
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Rosa
authors.initials: R
authors.lastname: Baños
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Cristina
authors.initials: C
authors.lastname: Botella
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Rafael
authors.initials: R
authors.lastname: de la Torre
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Jose C
authors.initials: JC
authors.lastname: Fernández-García
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Jose M
authors.initials: JM
authors.lastname: Fernández-Real
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Gema
authors.initials: G
authors.lastname: Frühbeck
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez-Ambrosi
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Susana
authors.initials: S
authors.lastname: Jiménez-Murcia
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Tinahones
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Xavier
authors.initials: X
authors.lastname: Estivill
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernández-Aranda
authors.affiliation: Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut
authors.forename: Ruben
authors.initials: R
authors.lastname: Nogueiras
mesh_terms: D000293:Adolescent; D000328:Adult; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D000856:Anorexia Nervosa / Q000097:blood*; D001786:Blood Glucose; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood*; D036361:Peptide Hormones / Q000097:blood*; D055815:Young Adult
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D036361:Peptide Hormones