title: Speech preparation in adults with persistent developmental stuttering.
abstract: Motor efference copy conveys movement information to sensory areas before and during vocalization. We hypothesized speech preparation would modulate auditory processing, via motor efference copy, differently in men who stutter (MWS) vs. fluent adults. Participants (n=12/group) had EEG recorded during a cue-target paradigm with two conditions: speech which allowed for speech preparation, while a control condition did not. Acoustic stimuli probed auditory responsiveness between the cue and target. MWS had longer vocal reaction times (p<0.01) when the cue-target differed (10% of trials), suggesting a difficulty of rapidly updating their speech plans. Acoustic probes elicited a negative slow wave indexing motor efference copy that was smaller in MWS vs. fluent adults (p<0.03). Current density responses in MWS showed smaller left prefrontal responses and auditory responses that were delayed and correlated to stuttering rate. Taken together, the results provide insight into the cortical mechanisms underlying atypical speech planning and dysfluencies in MWS.
authors.affiliation: Department of Psychology, Tulane University, United States. Electronic address: jmock@tulane.edu.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Mock
authors.affiliation: Department of Neurology at University of Missouri, Kansas City School of Medicine, United States.
authors.forename: Anne L
authors.initials: AL
authors.lastname: Foundas
authors.affiliation: Department of Psychology, Tulane University, United States; Program in Neuroscience, Tulane University, United States.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Golob
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D003463:Cues; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D017397:Prefrontal Cortex / Q000503:physiopathology; D011930:Reaction Time; D013060:Speech / Q000502:physiology; D013067:Speech Perception; D013342:Stuttering / Q000503:physiopathology*; D055815:Young Adult
keywords: Auditory event-related potentials; Motor efference copy; Speech preparation; Stuttering