title: A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal.
abstract: This work assessed the antioxidant potential, acetylcholinesterase (AChE) inhibition and the in vitro cytotoxic activity of extracts of the seagrasses Zostera marina and Zostera noltei collected from southern Portugal. The total phenolic contents (TPCs), the rosmarinic acid (RA) concentration (HPLC/DAD) and the fatty acid (FA) profile (GC/MS) are also described. Z. marina had the highest TPC, radical scavenging activity against DPPH radicals and copper chelating activity. Z. noltei had metal chelation capacity to copper and iron ions. None of the species was able to inhibit AChE. Both seagrasses had high levels of polyunsaturated FAs. Z. marina significantly and selectively reduced the viability of tumorous neuronal cells. Z. noltei was highly toxic for the three cell lines tested and was selective against hepatocarcinoma cells at the concentration of 100 μg/mL. RA was the main compound identified in Z. marina, but not in Z. noltei.
authors.affiliation: a Center of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas , 8005-139 Faro , Portugal.
authors.forename: Luísa
authors.initials: L
authors.lastname: Custódio
authors.affiliation: a Center of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas , 8005-139 Faro , Portugal.
authors.forename: Simona
authors.initials: S
authors.lastname: Laukaityte
authors.affiliation: a Center of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas , 8005-139 Faro , Portugal.
authors.forename: Aschwin H
authors.initials: AH
authors.lastname: Engelen
authors.affiliation: a Center of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas , 8005-139 Faro , Portugal.
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Rodrigues
authors.affiliation: a Center of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas , 8005-139 Faro , Portugal.|b Department of Chemistry and Science of Materials , Faculty of Experimental Sciences, University of Huelva , Avda. Fuerzas Armadas s/n, Huelva 21007 Spain.
authors.forename: Hugo
authors.initials: H
authors.lastname: Pereira
authors.affiliation: a Center of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas , 8005-139 Faro , Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Vizetto-Duarte
authors.affiliation: a Center of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas , 8005-139 Faro , Portugal.
authors.forename: Luísa
authors.initials: L
authors.lastname: Barreira
authors.affiliation: d Institute for Research in Biomedicine , Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona , Spain.
authors.forename: Hortensia
authors.initials: H
authors.lastname: Rodríguez
authors.affiliation: c School of Chemistry, Yachay Tech, Yachay City of Knowledge , 100119 Urcuqui , Ecuador.|d Institute for Research in Biomedicine , Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona , Spain.|e School of Chemistry, University of KwaZulu-Natal , 4001 Durban , South Africa.
authors.forename: Fernando
authors.initials: F
authors.lastname: Alberício
authors.affiliation: a Center of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas , 8005-139 Faro , Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Varela
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry / Q000302:isolation & purification; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D002934:Cinnamates / Q000302:isolation & purification; D053630:Depsides / Q000302:isolation & purification; D005227:Fatty Acids / Q000737:chemistry; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*; D011174:Portugal; D035962:Zosteraceae / Q000737:chemistry* / Q000145:classification; D000097123:Rosmarinic Acid
chemical_list: D000975:Antioxidants; D002614:Chelating Agents; D002800:Cholinesterase Inhibitors; D002934:Cinnamates; D053630:Depsides; D005227:Fatty Acids; D010636:Phenols; D010936:Plant Extracts; D000097123:Rosmarinic Acid
keywords: PUFA; cytotoxicity; oxidative stress; rosmarinic acid; seagrasses