title: Effects of Curculigoside on Memory Impairment and Bone Loss via Anti-Oxidative Character in APP/PS1 Mutated Transgenic Mice.
abstract: Alzheimer's disease (AD) and osteoporosis are two closely related multifactorial progressively degenerative diseases that predominantly affect aged people. These two diseases share many common risk factors, including old age, being female, smoking, excessive drinking, low estrogen, and vitamin D3 levels. Additionally, oxidative damage and the dysfunction of the antioxidant system play important roles in the pathogenesis of osteoporosis and AD. Aβ not only leads to impaired memory but also plays a crucial role in the demineralization process of bone tissues of older people and women with menopause. Curculigoside can promote calcium deposition and increase the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character. Therefore, we investigated the effects of CUR on the spatial learning and memory by the Morris water maze and brain immunohistochemistry, and bone microstructure and material properties of femurs by micro-computed tomography and mechanical testing in APP/PS1 mutated transgenic mice. Oral administration of CUR can significantly enhance learning performance and ameliorate bone loss in APP/PS1 mutated transgenic mice, and the mechanism may be related to its antioxidant effect. Based on these results, CUR has real potential as a new natural resource for developing medicines or dietary supplements for the prevention and treatment of the two closely linked multifactorial progressive degenerative disorders, AD and osteoporosis.
authors.affiliation: School of Pharmacy, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Pharmacology, School of Pharmacy, Chengdu Medical College, Sichuan, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.affiliation: People's Liberation Army (PLA) 455 Hospital, Shanghai, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai, China.
authors.forename: Qiaoyan
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Zejian
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yin
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001565:Benzoates / Q000494:pharmacology / Q000627:therapeutic use*; D001696:Biomechanical Phenomena / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001862:Bone Resorption / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D005269:Femur / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D008569:Memory Disorders / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics*; D053764:Presenilin-1 / Q000235:genetics; D065852:Spatial Memory / Q000187:drug effects; D000071681:Tartrate-Resistant Acid Phosphatase; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016564:Amyloid beta-Protein Precursor; D000975:Antioxidants; D001565:Benzoates; D005960:Glucosides; D015850:Interleukin-6; D007527:Isoenzymes; D053764:Presenilin-1; D014409:Tumor Necrosis Factor-alpha; C477170:curculigoside; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase