title: Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population.
abstract: Polymorphisms in microRNA (miRNA) binding site have been widely discussed to be associated with cancer risk; however, the associations were unclear in Chinese population. To investigate the associations of five polymorphisms (rs11097457, rs1434536, rs1970801, rs1044129, rs11169571) in miRNA binding sites with breast cancer risk, a total of 435 female patients with breast cancer and 439 age- and gender-matched tumor-free individuals were enrolled in this case-control study. Sequenom MassARRAY was applied to detect the polymorphisms, and the immunohistochemistry assay was used to measure the expression of estrogen receptor (ER) and progesterone receptor (PR) and CerbB-2. The data showed that these polymorphisms were not associated with breast cancer risk or clinical characters of breast cancer in all participants and sub-group with the exception that, in the sub-group of women with their first menstruation after 14 years old, those who carried rs1970801 T allele (genotype TT/GT) were associated with decreased breast cancer risk. In short, this case-control study provided the evidence that women with their first menstruation after 14 years old and carried rs1970801 T allele (genotype TT/GT) were associated with decreased breast cancer risk.
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China.
authors.forename: Bang-Shun
authors.initials: BS
authors.lastname: He
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Pan
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Lin
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China.
authors.forename: Hou-Qun
authors.initials: HQ
authors.lastname: Ying
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China.
authors.forename: Qi-Wen
authors.initials: QW
authors.lastname: Deng
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Sun
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China.
authors.forename: Tian-Yi
authors.initials: TY
authors.lastname: Gao
authors.affiliation: The Central Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006 Jiangsu Province, China. Electronic address: shukwang@163.com.
authors.forename: Shu-Kui
authors.initials: SK
authors.lastname: Wang
mesh_terms: D000328:Adult; D001665:Binding Sites; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D035683:MicroRNAs
keywords: Breast cancer; MicroRNA binding sites; Polymorphism