title: Coexpression networks identify brain region-specific enhancer RNAs in the human brain.
abstract: Despite major progress in identifying enhancer regions on a genome-wide scale, the majority of available data are limited to model organisms and human transformed cell lines. We have identified a robust set of enhancer RNAs (eRNAs) expressed in the human brain and constructed networks assessing eRNA-gene coexpression interactions across human fetal brain and multiple adult brain regions. Our data identify brain region-specific eRNAs and show that enhancer regions expressing eRNAs are enriched for genetic variants associated with autism spectrum disorders.
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Pu
authors.initials: P
authors.lastname: Yao
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Peijie
authors.initials: P
authors.lastname: Lin
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Akira
authors.initials: A
authors.lastname: Gokoolparsadh
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Amelia
authors.initials: A
authors.lastname: Assareh
authors.affiliation: QFAB Bioinformatics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.
authors.forename: Mike W C
authors.initials: MW
authors.lastname: Thang
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Irina
authors.initials: I
authors.lastname: Voineagu
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D002460:Cell Line; D002659:Child Development Disorders, Pervasive / Q000235:genetics*; D002843:Chromatin / Q000378:metabolism*; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D005333:Fetus; D015870:Gene Expression / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D012313:RNA / Q000378:metabolism*; D017423:Sequence Analysis, RNA; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D002843:Chromatin; D012313:RNA