title: Vincristine-Induced Neuropathy Presenting as Ptosis and Ophthalmoplegia in a 2-Year-Old Boy.
abstract: Vincristine is used in the treatment of leukemias, solid tumors, and lymphomas. A case of a 2-year-old boy undergoing treatment for leukemia who developed sudden onset bilateral ptosis and ophthalmoplegia along with generalized neuropathy due to vincristine's neurotoxic effects is presented. He was successfully treated with pyridoxine and pyridostigmine. The possible mechanisms of action and the treatment for vincristine-induced neuropathy are discussed. Prompt treatment and close follow-up is needed, especially in children because prolonged ptosis and motility restriction may have a profound effect on a child's visual function.
authors.forename: Amit H
authors.initials: AH
authors.lastname: Palkar
authors.forename: Akshay Gopinathan
authors.initials: AG
authors.lastname: Nair
authors.forename: Roshani J
authors.initials: RJ
authors.lastname: Desai
authors.forename: Nayana A
authors.initials: NA
authors.lastname: Potdar
authors.forename: Chhaya A
authors.initials: CA
authors.lastname: Shinde
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects; D001763:Blepharoptosis / Q000139:chemically induced* / Q000175:diagnosis; D002675:Child, Preschool; D005133:Eye Movements / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009886:Ophthalmoplegia / Q000139:chemically induced* / Q000175:diagnosis; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine