title: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma.
abstract: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare, and the etiology of disease is not fully understood. We present herein the case of a primary hepatic MALT lymphoma with Helicobacter pylori and hepatitis C virus infection. A 71-year-old male was admitted to our institution to undergo a precise evaluation of a hepatic tumor incidentally detected during a computed tomography (CT) scan for chest examination. Dynamic CT showed faint enhancement during the arterial phase. The gadoxetate disodium-enhanced magnetic resonance imaging showed a hyper-intensity on the arterial phase and low intensity during the late and hepatocyte phases. Liver biopsy specimen showed small to intermediate size atypical lymphocytes with positive CD20 immunohistochemical staining. It was finally diagnosed as primary hepatic MALT lymphoma. FDG-PET/CT showed faintly increased uptake with a maximum standardized uptake value of 4.6, and did not show other pathological uptake. We present the rare case of primary hepatic MALT lymphoma and discussed the etiology of this disease.
authors.affiliation: Department of Gastroenterology, Fuji Heavy Industries Health Insurance Society, Ota Memorial Hospital, Ota, Gunma, 373-8585, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hamada
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan. kakizaki@showa.gunma-u.ac.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kakizaki
authors.affiliation: Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Koiso
authors.affiliation: Department of Hematology, Gunma Prefectural Cancer Center, Ota, Gunma, 373-8500, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Irisawa
authors.affiliation: Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan.
authors.forename: Sumihito
authors.initials: S
authors.lastname: Nobusawa
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
keywords: Helicobacter pylori; Hepatitis C virus; Liver neoplasms; Lymphoma