title: Sex-Specific Patterns of Aberrant Brain Function in First-Episode Treatment-Naive Patients with Schizophrenia.
abstract: Male and female patients with schizophrenia show significant differences in a number of important clinical features, yet the neural substrates of these differences are still poorly understood. Here we explored the sex differences in the brain functional aberrations in 124 treatment-naïve patients with first-episode schizophrenia (61 males), compared with 102 age-matched healthy controls (50 males). Maps of degree centrality (DC) and amplitude of low-frequency fluctuations (ALFF) were constructed using resting-state functional magnetic resonance imaging data and compared between groups. We found that: (1) Selective DC reduction was observed in the right putamen (Put_R) in male patients and the left middle frontal gyrus (MFG) in female patients; (2) Functional connectivity analysis (using Put_R and MFG as seeds) found that male and female patients have disturbed functional integration in two separate networks, i.e., the sensorimotor network and the default mode network; (3) Significant ALFF alterations were also observed in these two networks in both genders; (4) Sex specific brain functional alterations were associated with various symptoms in patients. These results suggested that sex-specific patterns of functional aberration existed in schizophrenia, and these patterns were associated with the clinical features both in male and female patients.
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. lw17022@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Lei
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. xinzhishui@tom.com.
authors.forename: Mingli
authors.initials: M
authors.lastname: Li
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. mrdengwei@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.affiliation: Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Branch Hospital of West China Hospital, Sichuan University, Chengdu 610041, China. znxc119@sina.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. maxiaohong@scu.edu.cn.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. wangqiang130@hotmail.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. guowjcn@163.com.
authors.forename: Wanjun
authors.initials: W
authors.lastname: Guo
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. li-yinfei@163.com.
authors.forename: Yinfei
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. doctorjiangli@163.com.
authors.forename: Lijun
authors.initials: L
authors.lastname: Jiang
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. maggiehyy2011@hotmail.com.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Han
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. chaohua118@gmail.com.
authors.forename: Chaohua
authors.initials: C
authors.lastname: Huang
authors.affiliation: Biobank, West China Hospital, Sichuan University, Chengdu 610041, China. hxxhu99@gmail.com.
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. litaohx@scu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012727:Sex Characteristics
keywords: brain functional network; functional MRI; schizophrenia; sex difference