title: Carotid Plaques Correlates in Patients With Familial Hypercholesterolemia.
abstract: Patients with familial hypercholesterolemia (FH) are at increased risk of premature cardiovascular disease. We compared factors associated with the presence of carotid plaques and carotid intima-media thickness (cIMT), markers of subclinical atherosclerosis, in 241 patients with FH (98, 40.7% men; mean age 41 ± 18.4 years). Patients with FH having carotid plaques (36.5%) had mean age, apolipoprotein (apo) B, glucose, apoA1, systolic blood pressure (SBP) and diastolic BP, waist/hip ratio (WHR), and body mass index higher than patients without plaques. Logistic regression revealed that apoB (odds ratio [OR] per 1 unit change 1.03,P= .005), high-density lipoprotein cholesterol (HDL-C; OR per 1 standard deviation [SD] change 0.59,P= .015), and non-HDL-C (OR per 1SD change 1.53,P= .04) were significantly associated with the presence of plaques. The cIMT correlated with obesity parameters, BP, apoB, glucose, high-sensitivity C-reactive protein, creatinine, γ-glutamyl transpeptidase, and alanine transaminase (P< .001). Regression analysis revealed that cIMT was significantly associated with apoB, SBP, and WHR. These results confirm the role of apoB-containing lipoproteins and low HDL-C with the presence of carotid plaques and apoB, BP, and WHR with cIMT.
authors.affiliation: Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland mmwalus@wp.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Waluś-Miarka
authors.affiliation: First Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Czarnecka
authors.affiliation: First Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Wojciechowska
authors.affiliation: First Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Kloch-Badełek
authors.affiliation: Department of Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Kapusta
authors.affiliation: Second Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Sanak
authors.affiliation: Department of Pediatric and Adolescent Endocrinology, Pediatric Institute, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Wójcik
authors.affiliation: Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: M T
authors.initials: MT
authors.lastname: Małecki
authors.affiliation: Department of Pediatric and Adolescent Endocrinology, Pediatric Institute, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Starzyk
authors.affiliation: Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Idzior-Waluś
mesh_terms: D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood / Q000150:complications*; D001794:Blood Pressure / Q000502:physiology; D059168:Carotid Intima-Media Thickness; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL
keywords: apolipoprotein B; carotid intima–media thickness; carotid plaques; familial hypercholesterolemia