title: Topical R1 and R2 Prophylactic Treatment of Acute Radiation Dermatitis in Squamous Cell Carcinoma of the Head and Neck and Breast Cancer Patients Treated With Chemoradiotherapy.
abstract: OBJECTIVE
  A clinical study was conducted on the use of the topical Lactokine-based R1 and R2 system as a prophylactic treatment of acute radiation dermatitis in patients with squamous cell cancer of the head and neck and breast cancer treated with chemoradiotherapy.
  
  
  METHODS
  Ninety-eight patients were studied who attended the Radiation Oncology Services, La Paz University Hospital, Madrid, for treatment with chemoradiotherapy for head and neck cancer (n = 19) and breast cancer (n = 79). The treatment group (R1 and R2) included 51 patients; 47 control patients were given the local standard topical treatment (5% wt/wt urea lotion). At 3 postradiotherapy follow-up clinics, radiation dermatitis was graded, if present. All patients were administered with "quality-of-life" questionnaires.
  
  
  RESULTS
  Treatment with R1 and R2 significantly reduced the grade of radiation dermatitis in patients treated with chemoradiotherapy. At the fourth (last) clinic visit, at 2 weeks following the end of radiation treatment, 66.7% of patients in the treated group (R1 and R2) were free from radiation dermatitis compared with 34% in those given the center's usual skin care (topical urea lotion). There were no reported side effects, and quality of life improved for patients treated with R1 and R2.
  
  
  CONCLUSIONS
  Topical skin treatment with the R1 and R2 system has been shown to be effective in preventing, reducing the onset, and reducing the degree (grade) of radiation dermatitis in head and neck and breast cancer patients treated with chemoradiation.
authors.affiliation: Radiation Oncology Department, La Paz University Hospital, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Manas
authors.affiliation: Foundation for Biomedical Research, Radiation Oncology Department, La Paz University Hospital, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Santolaya
authors.affiliation: Nursing Unit, IMO Group, Madrid Institute of Oncology, Madrid, Spain.
authors.forename: Violeta Mirela
authors.initials: VM
authors.lastname: Ciapa
authors.affiliation: Radiation Oncology Department, La Paz University Hospital, Madrid, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Belinchón
authors.affiliation: Water-Jel Europe LLP, Unit 3&4, The Mead Business Centre, Hertford, United Kingdom.
authors.forename: Frances
authors.initials: F
authors.lastname: Tully
keywords: breast cancer; chemoradiotherapy; head and neck cancer; prophylaxis; radiation dermatitis