title: Literature review and meta-analysis of translaminar pressure difference in open-angle glaucoma.
abstract: There is increasing evidence in the literature regarding translaminar pressure difference's (TPD) role in the pathophysiology of glaucoma. The optic nerve is exposed not only to intraocular pressure in the eye, but also to intracranial pressure (ICP), as it is surrounded by cerebrospinal fluid in the subarachnoid space. Although pilot studies have identified the potential importance of TPD in glaucoma, limited available data currently prevent a comprehensive description of the role that TPD may have in glaucomatous pathophysiology. In this review, we present all available qualified data from a systematic review of the literature of the role of TPD in open-angle glaucoma (OAG). PubMed (Medline), OVID Medline, ScienceDirect, SpringerLink, and all available library databases were reviewed and subsequent meta-analysis of pooled mean differences are presented where appropriate. Five papers including 396 patients met criteria for inclusion to the analysis. Importantly, we included all observational studies despite differences in ICP measurement methods, as there is no consensus regarding best-practice ICP measurements in glaucoma. Our results show that not only TPD is higher in glaucoma patients compared with healthy subjects, it is related to structural glaucomatous changes of the optic disc. Our analysis suggests further longitudinal prospective studies are needed to investigate the influence of TPD in OAG, with a goal of overcoming methodological weaknesses of previous studies.
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: L
authors.initials: L
authors.lastname: Siaudvytyte
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: I
authors.initials: I
authors.lastname: Januleviciene
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: A
authors.initials: A
authors.lastname: Daveckaite
authors.affiliation: Health Telematics Science Centre of Kaunas University of Technology, Kaunas, Lithuania.
authors.forename: A
authors.initials: A
authors.lastname: Ragauskas
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.|Health Telematics Science Centre of Kaunas University of Technology, Kaunas, Lithuania.
authors.forename: L
authors.initials: L
authors.lastname: Bartusis
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: J
authors.initials: J
authors.lastname: Kucinoviene
authors.affiliation: Glaucoma Research and Diagnostic Center, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: B
authors.initials: B
authors.lastname: Siesky
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.|Glaucoma Research and Diagnostic Center, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: A
authors.initials: A
authors.lastname: Harris
mesh_terms: D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D007429:Intraocular Pressure / Q000502:physiology*; D009901:Optic Nerve Diseases / Q000503:physiopathology*