title: Nucleosome Dancing at the Tempo of Histone Tail Acetylation.
abstract: The impact of histone acetylation on transcription was revealed over 50 years ago by Allfrey and colleagues. However, it took decades for an understanding of the fine mechanism by which this posttranslational modification affects chromatin structure and promotes transcription. Here, we review breakthroughs linking histone tail acetylation, histone dynamics, and transcription. We also discuss the histone exchange during transcription and highlight the important function of a pool of non-chromatinized histones in chromatin dynamics.
authors.affiliation: UMR CNRS 6286 UFIP, Université de Nantes, Epigénétique: Proliferation et Différenciation, 2 rue de Houssinière, 44322 Nantes Cedex 03, France. Angelique.Galvani@univ-nantes.fr.
authors.forename: Angélique
authors.initials: A
authors.lastname: Galvani
authors.affiliation: UMR CNRS 6286 UFIP, Université de Nantes, Epigénétique: Proliferation et Différenciation, 2 rue de Houssinière, 44322 Nantes Cedex 03, France. Christophe.Thiriet@univ-nantes.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Thiriet
keywords: chromatin dynamics; histone acetylation; transcription