title: Second Primary Cancer after Diagnosis and Treatment of Cervical Cancer.
abstract: OBJECTIVE
  This study was conducted to investigate the incidence and survival outcomes of second primary cancers after the diagnosis of cervical cancer.
  
  
  METHODS
  Data from the Korea Central Cancer Registry between 1993 and 2010 were reviewed and analyzed. Standardized incidence ratios (SIRs) of second primary cancers among women with cervical cancer were analyzed. Kaplan-Meier survival curves were constructed for cervical cancer patients with or without a second primary cancer.
  
  
  RESULTS
  Among 72,805 women with cervical cancer, 2,678 (3.68%) developed a second primary cancer within a mean follow-up period of 7.34 years. The overall SIR for a second cancer was 1.08 (95% confidence interval, 1.04 to 1.12). The most frequent sites of second primary cancers were the vagina, bone and joints, vulva, anus, bladder, lung and bronchus, corpus uteri, and esophagus. However, the incidence rates of four second primary cancers (breast, rectum, liver, and brain) were decreased. The 5-year and 10-year overall survival rates were 78.3% and 72.7% in all women with cervical cancer, and for women with a second primary cancer, these rates were 83.2% and 65.5% from the onset of cervical cancer and 54.9% and 46.7% from the onset of the second primary cancer, respectively.
  
  
  CONCLUSIONS
  The incidence rates of second primary cancers were increased in women with cervical cancer compared to the general population, with the exception of four decreasing cancers. The 10-year overall survival rates were decreased in cervical cancer patients with a second primary cancer.
authors.affiliation: Gynecologic Cancer Branch, National Cancer Center, Goyang, Korea.|Center for Uterine Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Myong Cheol
authors.initials: MC
authors.lastname: Lim
authors.affiliation: Cancer Registration and Statistics Branch, National Cancer Center, Goyang, Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Won
authors.affiliation: Cancer Registration and Statistics Branch, National Cancer Center, Goyang, Korea.
authors.forename: Jiwon
authors.initials: J
authors.lastname: Lim
authors.affiliation: Center for Uterine Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Yeon-Joo
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Center for Uterine Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Seo
authors.affiliation: Gynecologic Cancer Branch, National Cancer Center, Goyang, Korea.|Center for Uterine Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Sokbom
authors.initials: S
authors.lastname: Kang
authors.affiliation: Center for Breast Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Lee
authors.affiliation: Center for Colorectal Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Oh
authors.affiliation: Center for Uterine Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Gynecologic Cancer Branch, National Cancer Center, Goyang, Korea.|Center for Uterine Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Park
mesh_terms: D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D016609:Neoplasms, Second Primary; D056910:Republic of Korea; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000628:therapy
keywords: Cervix uteri; Korean; Neoplasms; Second primary neoplasm