title: Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma.
abstract: Naringin, a well known component isolated from Exocarpium Citri Grandis, has significant antitussive effects. Recently, Naringin exhibited novel anti-inflammatory effect in chronic inflammatory diseases. In this work, we firstly evaluated the effects of naringin on enhanced cough, airway hyper-responsiveness (AHR), and airway inflammation in an ovalbumin-induced experimental cough-variant asthma (CVA) model in guinea pigs. We investigated the effect of naringin (18.4 mg/kg, per os, single dose or consecutively) on cough to inhaled capsaicin after challenge with an aerosolized antigen in actively sensitized guinea pigs. The effect of naringin on AHR to inhaled methacholine was evaluated 24 h after cough determination. Airway inflammation was assessed via bronchoalveolar lavage fluid (BALF) cytology and lung histopathology. Naringin, given consecutively, significantly reduced ovalbumin-induced enhanced cough and AHR, inhibited the increases in the leukocytes, interleukin-4 (IL-4), IL-5, and IL-13 in BALF compared with the model group. Moreover, the pathologic changes in lung tissues were clearly ameliorated by naringin treatment. These results suggest that naringin may be a beneficial agent for CVA treatment.
authors.affiliation: Guangdong Key Laboratory of Plant Resources, Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China; Institute of Traditional Chinese Medicine, Guangdong Food and Drug Vocational College, Guangzhou, Guangdong, 510520, China.
authors.forename: Hao-yan
authors.initials: HY
authors.lastname: Jiao
authors.affiliation: Guangdong Key Laboratory of Plant Resources, Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China. Electronic address: lsssww@126.com.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Su
authors.affiliation: Guangdong Key Laboratory of Plant Resources, Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China.
authors.forename: Pei-bo
authors.initials: PB
authors.lastname: Li
authors.affiliation: Guangdong Key Laboratory of Plant Resources, Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Guangdong Key Laboratory of Plant Resources, Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Guangdong Key Laboratory of Plant Resources, Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhu
authors.affiliation: Guangdong Key Laboratory of Plant Resources, Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China.
authors.forename: Li-li
authors.initials: LL
authors.lastname: He
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D002211:Capsaicin / Q000008:administration & dosage; D003371:Cough / Q000188:drug therapy* / Q000276:immunology; D004195:Disease Models, Animal; D044950:Flavanones / Q000494:pharmacology*; D006168:Guinea Pigs; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D008297:Male; D010047:Ovalbumin / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D044950:Flavanones; D010047:Ovalbumin; C005274:naringin; D002211:Capsaicin
keywords: Airway hyper-responsiveness (AHR); Anti-inflammation; CVA; Cough; Naringin; Naringin (PubChem CID: 442428)