title: Plant Mediator complex and its critical functions in transcription regulation.
abstract: The Mediator complex is an important component of the eukaryotic transcriptional machinery. As an essential link between transcription factors and RNA polymerase II, the Mediator complex transduces diverse signals to genes involved in different pathways. The plant Mediator complex was recently purified and comprises conserved and specific subunits. It functions in concert with transcription factors to modulate various responses. In this review, we summarize the recent advances in understanding the plant Mediator complex and its diverse roles in plant growth, development, defense, non-coding RNA production, response to abiotic stresses, flowering, genomic stability and metabolic homeostasis. In addition, the transcription factors interacting with the Mediator complex are also highlighted.
authors.affiliation: State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, China.|The National Plant Gene Research Center (Beijing), Beijing 100101, China.
authors.forename: Li-Jia
authors.initials: LJ
authors.lastname: Qu
mesh_terms: D035264:Flowers / Q000502:physiology; D018506:Gene Expression Regulation, Plant; D056892:Mediator Complex / Q000378:metabolism*; D063245:Plant Development / Q000235:genetics; D010944:Plants / Q000235:genetics* / Q000276:immunology; D014158:Transcription, Genetic
chemical_list: D056892:Mediator Complex
keywords: Mediator complex; transcription factors; transcription regulation