title: Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans.
abstract: BACKGROUND
  This article reviews the current status of the Clinical Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI), and summarizes planning for the next stage of the project.
  
  
  METHODS
  Clinical Core activities and plans were synthesized based on discussions among the Core leaders and external advisors.
  
  
  RESULTS
  The longitudinal data in ADNI-2 provide natural history data on a clinical trials population and continue to inform refinement and standardization of assessments, models of trajectories, and clinical trial methods that have been extended into sporadic preclinical Alzheimer's disease (AD).
  
  
  CONCLUSIONS
  Plans for the next phase of the ADNI project include maintaining longitudinal follow-up of the normal and mild cognitive impairment cohorts, augmenting specific clinical cohorts, and incorporating novel computerized cognitive assessments and patient-reported outcomes. A major hypothesis is that AD represents a gradually progressive disease that can be identified precisely in its long presymptomatic phase, during which intervention with potentially disease-modifying agents may be most useful.
authors.affiliation: Department of Neurosciences, University of California San Diego, San Diego, CA, USA. Electronic address: paisen@ucsd.edu.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Aisen
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.affiliation: Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Donohue
authors.affiliation: Departments of Radiology and Biomedical Imaging, Medicine, Psychiatry and Neurology, University of California San Francisco, San Fransisco, CA, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000367:Age Factors; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis*; D002986:Clinical Trials as Topic / Q000266:history / Q000379:methods*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D003195:Computer Communication Networks; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008137:Longitudinal Studies; D059906:Neuroimaging / Q000266:history / Q000379:methods / Q000592:standards
keywords: Alzheimer's disease; Amyloid; Cognitive assessment