title: A crucial piece in the puzzle of the artemisinin resistance mechanism in Plasmodium falciparum.
abstract: The spread of resistance of malaria infections to artemisinin is a major concern for the future. The Plasmodium falciparum phosphatidylinositol-3-kinase (PfPI3K) may be a potential target of artemisinin and effector of resistance. This could be mediated by the Kelch13 protein, the molecular marker of resistance that modulates PfPI3K ubiquitination.
authors.affiliation: School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address: zbozdech@ntu.edu.sg.
authors.forename: Zbynek
authors.initials: Z
authors.lastname: Bozdech
authors.affiliation: School of Biological Sciences, Nanyang Technological University, Singapore.
authors.forename: Pedro E
authors.initials: PE
authors.lastname: Ferreira
authors.affiliation: School of Biological Sciences, Nanyang Technological University, Singapore.
authors.forename: Sachel
authors.initials: S
authors.lastname: Mok
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D037621:Artemisinins / Q000737:chemistry / Q000494:pharmacology*; D001210:Asia, Southeastern; D004351:Drug Resistance / Q000235:genetics / Q000502:physiology*; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000187:drug effects*; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D019869:Phosphatidylinositol 3-Kinases; D015800:Protozoan Proteins; C031327:artemisinin
keywords: artemisinin; drug resistance; malaria