title: [ETHIOLOGY OF LEPTOSPIROSIS IN GEORGIA].
abstract: Investigation of leptospirosis was initiated in 1950s, when the first cases in humans were detected in Gudauta rayon. Serology test confirmed the diagnose. High level of antibodies to serogroup Pomona was revealed in all cases. Later on the infection encountered as sporadic cases, the exception was 1986, when a large outbreak was reported in Sukhumi. At present leptospirosis is widely spread in the country, especially in Ajara region, where indicators of morbidity recently reached 11.4 per 100 thousand population. It is likely that warm humid climate creates exceptionally favorite conditions for spreading of Leptospira. In order to determine the true magnitude of the infection in the country a seroprevalence study was carried out in 50-60-ies of the past century in humans, agricultural animals and rodents. It was found that serotgroups Pomona, Icteroheamorrhagiae and Grippothypos prevailed in humans, Serogroup L. Pomona - dominated in animals, while in rodents the dominated serotgrouo was L. Icteroheamorrhagiae. Similar study, conducted by us in 1990-2005 showed that L.Pomona and L. Icteroheamorrhagiae prevailed in humans and rodents while L. Icteroheamorrhagiae was the only serogroup isolated in gray rats, trapped in Tbilisi. Infectivity of rodants composed 70%. Currently lesptosirosis is caused by a new serogroups of Leptospira - L. Sejroe, namely by serotypes Wolfii and Hardjo, L. Australis (serotype Bratislava) and L. Autumnalis along with the previously occurring serogroups L. Icteroheamorrhagiae, L. Bataviae, L. Hebdomadis. In our opinion the recent increase in leptospirosis in the country is attributable to the improvements in diagnostics of the infection as well as to the emergence of new serogroups of Leptospira, which in turn is a result of intensive migration processes in the country.
authors.affiliation: National Center for Disease Control and Public Health; Tbilisi State Medical University, Department of Public Health; I. Javakhisvili Tbilisi State University, Department of Public Health, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Mamuchishvili
authors.affiliation: National Center for Disease Control and Public Health; Tbilisi State Medical University, Department of Public Health; I. Javakhisvili Tbilisi State University, Department of Public Health, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Kuchuloria
authors.affiliation: National Center for Disease Control and Public Health; Tbilisi State Medical University, Department of Public Health; I. Javakhisvili Tbilisi State University, Department of Public Health, Georgia.
authors.forename: I
authors.initials: I
authors.lastname: Mchedlishvili
authors.affiliation: National Center for Disease Control and Public Health; Tbilisi State Medical University, Department of Public Health; I. Javakhisvili Tbilisi State University, Department of Public Health, Georgia.
authors.forename: P
authors.initials: P
authors.lastname: Imnadze
authors.affiliation: National Center for Disease Control and Public Health; Tbilisi State Medical University, Department of Public Health; I. Javakhisvili Tbilisi State University, Department of Public Health, Georgia.
authors.forename: D
authors.initials: D
authors.lastname: Mirzashvili
mesh_terms: D000818:Animals; D005846:Georgia (Republic); D006801:Humans; D007919:Leptospira / Q000472:pathogenicity*; D007922:Leptospirosis / Q000453:epidemiology* / Q000382:microbiology; D051381:Rats; D016036:Seroepidemiologic Studies