title: Neurogliaform cells in cortical circuits.
abstract: Recent research into local-circuit GABAergic inhibitory interneurons of the mammalian central nervous system has provided unprecedented insight into the mechanics of neuronal circuitry and its dysfunction. Inhibitory interneurons consist of a broad array of anatomically and neurochemically diverse cell types, and this suggests that each occupies an equally diverse functional role. Although neurogliaform cells were observed by Cajal over a century ago, our understanding of the functional role of this class of interneurons is in its infancy. However, it is rapidly becoming clear that this cell type operates under a distinct repertoire of rules to provide novel forms of inhibitory control of numerous afferent pathways.
authors.affiliation: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham. Shelby Building 1003, 1825 University Boulevard, Birmingham, Alabama 35294, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Overstreet-Wadiche
authors.affiliation: Program in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development. Porter Neuroscience, Building 35, Room 3C903, Lincoln Drive, Bethesda, Maryland 20892, USA.
authors.forename: Chris J
authors.initials: CJ
authors.lastname: McBain
mesh_terms: D000344:Afferent Pathways / Q000166:cytology* / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D007395:Interneurons / Q000166:cytology* / Q000502:physiology*