title: [Study of prognostic factors and prevalence of post-thrombotic syndrome in patients with deep vein thrombosis in Spain].
abstract: OBJECTIVE
  The prevalence of post-thrombotic syndrome (PTS) in Spain is not known accurately at present. The main objective of this study was to determine the prevalence of PTS and the possible prognostic factors related to its development and impact on quality of life.
  
  
  METHODS
  This was an observational, multicenter, cross-sectional and retrospective study of patients who had suffered a deep vein thrombosis (DVT) between March 2010 and March 2011. The Villalta scale was applied as a standardized assessment of PTS at the enrollment visit. According to the score, distribution was: patients with PTS (score>4) and patients without PTS (score ≤4). Subsequently, DVT data and risk factors were collected retrospectively. The quality of life of patients was evaluated.
  
  
  RESULTS
  In total 511 patients with DVT were enrolled, of which 7 patients were excluded as they did not meet the inclusion/exclusion criteria. The prevalence of PTS was 53%, with 56.2% having a mild character, 20.6% moderate, and 23.2% severe. The presence of risk factors for DVT including immobilization, hormonal therapy and obesity was significantly higher in patients with PTS than in patients without PTS. There were not significant differences in the location of the DVT. The perception of patients about their health was significantly worse in patients with DVT.
  
  
  CONCLUSIONS
  The prevalence of PTS in patients with DVT is very high. The presence of risk factors for DVT clearly contributes to a greater predisposition to suffering PTS in an average time of 2 years.
authors.affiliation: Servicio de Medicina Interna, Hospital Vall d'Hebron, Barcelona, España.
authors.forename: Josep
authors.initials: J
authors.lastname: Ordi
authors.affiliation: Servicio de Angiología y Cirugía Vascular, Hospital Clínico Universitario San Cecilio, Granada, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Salmerón
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Acosta
authors.affiliation: Departamento de Biometría, Alpha Bioresearch, Madrid, España. Electronic address: Isabel.camacho@alphabioresearch.com.
authors.forename: Isabel
authors.initials: I
authors.lastname: Camacho
authors.affiliation: Departamento Médico, Bayer Hispania S. L., Barcelona, España.
authors.forename: Núria
authors.initials: N
authors.lastname: Marín
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054070:Postthrombotic Syndrome / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D011379:Prognosis; D011788:Quality of Life; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D020246:Venous Thrombosis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000925:Anticoagulants
keywords: Calidad de vida; Deep vein thrombosis; Post-thrombotic syndrome; Prevalence; Prevalencia; Quality of life; Síndrome postrombótico; Trombosis venosa profunda