title: Two new isoaurones derivatives from Callistephus chinensis flower.
abstract: Two new isoaurones derivatives were obtained from Callistephus chinensis flower. Their structures were elucidated on the basis of extensive spectroscopic analyses. Both of the new compounds were evaluated cytotoxic activity. Phytochemical investigation of Callistephus chinensis flower led to the isolation of two new isoaurones derivatives (Z)-4',4,10-trihydroxy-siamaurone (1) and (E)-4',4,10-trihydroxy-siamaurone (2). The structures of these new compounds were identified by the interpretation of spectroscopic data (mainly 1D and 2D NMR) and by comparison with data reported in the literature. Both of the new compounds were evaluated for their cytotoxicity.
authors.affiliation: a School of Traditional Chinese Medicine, Shenyang Pharmaceutical University , Shenyang 110016 , People's Republic of China.|b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang PharmaceuticalUniversity , Shenyang 110016 , People's Republic of China.
authors.forename: Xiao-shu
authors.initials: XS
authors.lastname: Zhang
authors.affiliation: a School of Traditional Chinese Medicine, Shenyang Pharmaceutical University , Shenyang 110016 , People's Republic of China.|b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang PharmaceuticalUniversity , Shenyang 110016 , People's Republic of China.
authors.forename: Jia-qing
authors.initials: JQ
authors.lastname: Cao
authors.affiliation: c School of Pharmacy, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , People's Republic of China.
authors.forename: Guo-hui
authors.initials: GH
authors.lastname: Shi
authors.affiliation: d Chifeng MinYi Natural Anthocyanins Company Limited , Inner Mongolia Autonomous Region 024000 , People's Republic of China.
authors.forename: Zhen-ting
authors.initials: ZT
authors.lastname: Liu
authors.affiliation: d Chifeng MinYi Natural Anthocyanins Company Limited , Inner Mongolia Autonomous Region 024000 , People's Republic of China.
authors.forename: Jing-xin
authors.initials: JX
authors.lastname: Liu
authors.affiliation: a School of Traditional Chinese Medicine, Shenyang Pharmaceutical University , Shenyang 110016 , People's Republic of China.|b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang PharmaceuticalUniversity , Shenyang 110016 , People's Republic of China.
authors.forename: Yu-qing
authors.initials: YQ
authors.lastname: Zhao
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D002681:China; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D035264:Flowers / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: C000609681:(E)-4',4,10-trihydroxy-siamaurone; D001572:Benzofurans
keywords: Callistephus chinensis; cytotoxicity; isoaurones