title: Filopodia in cell adhesion, 3D migration and cancer cell invasion.
abstract: This review discusses recent advances in our understanding of the role filopodia and filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in vitro and in vivo. In particular, we focus on recent advances demonstrating that filopodia are involved in substrate tethering and environment sensing in vivo. We further discuss the emerging role of filopodia and filopodial proteins in tumor dissemination as mounting in vitro, in vivo and clinical evidence suggest that filopodia drive cancer cell invasion and highlight filopodia proteins as attractive therapeutic targets. Finally, we outline outstanding questions that remain to be addressed to elucidate the role of filopodia during 3D cell migration.
authors.affiliation: Turku Centre for Biotechnology, University of Turku, Tykistökatu 6A, FIN-20520 Turku, Finland.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Jacquemet
authors.affiliation: Turku Centre for Biotechnology, University of Turku, Tykistökatu 6A, FIN-20520 Turku, Finland.
authors.forename: Hellyeh
authors.initials: H
authors.lastname: Hamidi
authors.affiliation: Turku Centre for Biotechnology, University of Turku, Tykistökatu 6A, FIN-20520 Turku, Finland. Electronic address: joivaska@utu.fi.
authors.forename: Johanna
authors.initials: J
authors.lastname: Ivaska
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology; D011554:Pseudopodia / Q000378:metabolism