title: Effects of miR-339-5p on invasion and prognosis of hepatocellular carcinoma.
abstract: microRNAs (miRNAs) are short single-strand non-coding RNAs that regulate various cell processes at the post-transcriptional levels. Mounting evidences suggested that dysregulation of miRNA is associated with cancer progression and development. The aberrant expression of miR-339-5p has been found in some types of cancers, however, the association of miR-339-5p expression and hepatocellular carcinoma (HCC) is still unclear. Here, we measured the expression of miR-339-5p in HCC tissues and explored its clinicopathological and prognostic significance. The result showed that miR-339-5p expression level was significantly lower in HCC tissues compared with non-cancerous liver tissues. Moreover, patients with lower miR-339-5p expression level are associated with a poorer overall survival. Multivariate Cox regression analysis showed that the expression of miR-339-5p was an independent prognostic factor for HCC patients. In addition, we found that over-expression of miR-339-5p can inhibit HCC cell invasion. In conclusion, our results indicated that miR-339-5p may serve as a tumor suppressor and play important role in inhibiting tumor invasion. Our work implicates that miR-339-5p may serve as a prognostic marker and molecular therapeutic target in HCC.
authors.affiliation: Department of hepatic surgery, Fudan university Shanghai Cancer Center, 200032 Shanghai, China. Electronic address: yilin_wang002@163.com.
authors.forename: Yi-Lin
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Information center, The First Affiliated of Chongqing Medical University, China.
authors.forename: Chi-mei
authors.initials: CM
authors.lastname: Chen
authors.affiliation: Department of hepatobiliary surgery, Yi Ji-shan hospital, Wan Nan Medical College, 241000 Wuhu, Anhui Province, China. Electronic address: wxm6901@aliyun.com.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Department of hepatic surgery, Fudan university Shanghai Cancer Center, 200032 Shanghai, China. Electronic address: wang.lu@zs-hospital.sh.cn.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis
chemical_list: C543820:MIRN339 microRNA, human; D035683:MicroRNAs