title: Predictors of Clinical Success in the Treatment of Patients with Methicillin-Resistant Staphylococcus aureus (MRSA) Nosocomial Pneumonia (NP).
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) remains an important pathogen in nosocomial pneumonia and is associated with significant morbidity and mortality. Clinical outcomes for nosocomial pneumonia are dependent on patient age, co-morbidities, severity of illness and appropriate antibiotic therapy. The objective of this secondary analysis was to identify baseline clinical variables that are associated with clinical success at the end of the study observation period. Data from a randomized blinded trial (NCT00084266) comparing linezolid (600-mg twice daily) to vancomycin (15-mg/kg twice daily, dose-adjusted) for the treatment of culture-proven MRSA pneumonia were analyzed to evaluate baseline clinical and demographic factors that may predict clinical success at end of study (EOS) (7-30 days after end of treatment). A multivariate logistic regression was conducted to identify baseline factors that are associated with clinical success. Patients treated with linezolid (OR 1.55 95% CI: 1.013, 2.355), no vasopressor receipt (OR 2.30, 95% CI: 1.303, 4.069), unilateral involvement (OR 1.70, 95% CI: 1.078, 2.681) and normal renal function (eGFR 30-80 vs >80 OR 0.48, 95% CI: 0.303, 0.750) were more likely to have clinical success. From a clinical standpoint, identifying reliable predictors of outcome and who might benefit more from one therapy versus another can help inform treatment decisions.
authors.affiliation: Pulmonary Critical Care; Washington Hospital Center, Washington, DC, United States of America.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Shorr
authors.affiliation: Infectious Diseases and Vaccines; Pfizer Inc, Collegeville, Pennsylvania, United States of America.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Puzniak
authors.affiliation: Biostatistics, Pfizer Inc, Collegeville, Pennsylvania, United States of America.
authors.forename: Pinaki
authors.initials: P
authors.lastname: Biswas
authors.affiliation: Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, New York, United States of America.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Niederman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003428:Cross Infection / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D000069349:Linezolid / Q000008:administration & dosage*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008875:Middle Aged; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy* / Q000503:physiopathology; D014640:Vancomycin / Q000008:administration & dosage*
chemical_list: D014640:Vancomycin; D000069349:Linezolid