title: Fucoidan Prevents the Progression of Osteoarthritis in Rats.
abstract: This study investigated the effects of fucoidan (extract from Hizikia fusiforme) on symptoms and inflammatory cytokine activation in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Forty male SD rats were divided into five groups, including normal, negative control (MIA), positive control (Lyprinol), and two experimental groups treated with 50 or 100 mg/kg fucoidan. Weight-bearing assessments were done after MIA injection into the right knee to induce OA. After 14 days of treatment, microcomputed tomographic (micro-CT) images were made of rat knee joints, and then animals were sacrificed for joint histology and inflammatory cytokine level assessments. MIA injection successfully induced OA by causing 40% weight-bearing imbalance, severe bone loss and cartilage degeneration, and markedly increased cytokine levels. However, fucoidan groups showed over 45% of imbalance and no articular cartilage surface lesions or change in subchondral trabecular bones in Micro-CT images. Histological analysis revealed that cartilage morphology and cell counts were also normal in the 100 mg/kg fucoidan group. In addition, the 100 mg/kg fucoidan groups exhibited lower serum tumor necrosis factor alpha (TNF-α) (30%), interleukin 1 beta (IL-1β) (48%), and matrix metalloproteinase-1 (MMP-1) (65%) compared to the MIA groups. These results suggest that administration of fucoidan prevents the progression of OA in a MIA-induced OA rat model.
authors.affiliation: 1 Department of Oriental Medicinal Materials & Processing, College of Life Science, Kyung Hee University , Gyeonggi-do, Korea.|2 Graduate School of Biotechnology, Kyung Hee University , Gyeonggi-do, Korea.
authors.forename: Don-Gil
authors.initials: DG
authors.lastname: Lee
authors.affiliation: 1 Department of Oriental Medicinal Materials & Processing, College of Life Science, Kyung Hee University , Gyeonggi-do, Korea.
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Park
authors.affiliation: 3 Department of Rehabilitation Medicine of Korean Medicine, Kyung Hee University , Seoul, Korea.
authors.forename: Won-Seok
authors.initials: WS
authors.lastname: Chung
authors.affiliation: 1 Department of Oriental Medicinal Materials & Processing, College of Life Science, Kyung Hee University , Gyeonggi-do, Korea.
authors.forename: Jae-Hee
authors.initials: JH
authors.lastname: Park
authors.affiliation: 1 Department of Oriental Medicinal Materials & Processing, College of Life Science, Kyung Hee University , Gyeonggi-do, Korea.
authors.forename: Eunson
authors.initials: E
authors.lastname: Hwang
authors.affiliation: 4 Center of Genomic Technologies, Institute of Genetics and Plant Experimental Biology , Academy Sciences of Uzbekistan, Tashkent, Uzbekistan .
authors.forename: Gafurjon Tom
authors.initials: GT
authors.lastname: Mavlonov
authors.affiliation: 5 Division of Metabolism and Functionality Research, Korea Food Research Institute , Gyeonggi-do, Korea.
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Kim
authors.affiliation: 2 Graduate School of Biotechnology, Kyung Hee University , Gyeonggi-do, Korea.
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Kim
authors.affiliation: 1 Department of Oriental Medicinal Materials & Processing, College of Life Science, Kyung Hee University , Gyeonggi-do, Korea.|2 Graduate School of Biotechnology, Kyung Hee University , Gyeonggi-do, Korea.
authors.forename: Tae-Hoo
authors.initials: TH
authors.lastname: Yi
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001842:Bone and Bones / Q000187:drug effects; D002357:Cartilage Diseases / Q000517:prevention & control; D002358:Cartilage, Articular / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D018450:Disease Progression; D053583:Interleukin-1beta / Q000378:metabolism; D007461:Iodoacetates; D007719:Knee Joint / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D020370:Osteoarthritis, Knee / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley; D044647:Sargassum / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D055114:X-Ray Microtomography
chemical_list: D053583:Interleukin-1beta; D007461:Iodoacetates; D010936:Plant Extracts; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; C007789:fucoidan; C576840:MMP1 protein, rat; D020781:Matrix Metalloproteinase 1
keywords: MIA-induced rat; health functional food; matrix metalloproteinases; osteoarthritis; seaweeds