title: Intracranial meningeal hemangiopericytoma: Recurrences at the initial and distant intracranial sites and extraneural metastases to multiple organs.
abstract: Regardless of the controversial pathogenesis, intracranial meningeal hemangiopericytoma (M-HPC) is a rare, highly cellular and vascularized mesenchymal tumor that is characterized by a high tendency for recurrence and extraneural metastasis, despite radical excision and postoperative radiotherapy. M-HPC shares similar clinical manifestations and radiological findings with meningioma, which causes difficulty in differentiation of this entity from those prognostically favorable mimics prior to surgery. Treatment of M-HPC, particularly in metastatic settings, remains a challenge. A case is described of primary M-HPC with recurrence at the initial and distant intracranial sites and extraneural multiple-organ metastases in a 36-year-old female. The metastasis of M-HPC was extremely extensive, and to the best of our knowledge this is the first case of M-HPC with delayed metastasis to the bilateral kidneys. The data suggests that preoperative computed tomography and magnetic resonance imaging could provide certain diagnostic clues and useful information for more optimal treatment planning. The results may imply that novel drugs, such as temozolomide and bevacizumab, as a component of multimodality therapy of M-HPC may deserve further investigation.
authors.affiliation: Department of Radiology and Molecular Imaging, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P.R. China.
authors.forename: Guangquan
authors.initials: G
authors.lastname: Wei
authors.affiliation: Department of Radiology and Molecular Imaging, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P.R. China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Kang
authors.affiliation: Department of Radiology and Molecular Imaging, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P.R. China.
authors.forename: Xianping
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Radiology and Molecular Imaging, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P.R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P.R. China.
authors.forename: Qinlong
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P.R. China.
authors.forename: Juntao
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Radiology and Molecular Imaging, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
keywords: brain tumor; computed tomography treatment; magnetic resonance imaging; meningeal hemangiopericytoma; metastasis