title: Synthesis of stable isotopically labelled 3-methylfuran-2(5H)-one and the corresponding strigolactones.
abstract: Conventional synthetic procedures of strigolactones (SLs) involve the independent synthesis of ring ABC and ring D, followed by a coupling of the two fragments. Here we prepared three kinds of stable, isotopically labelled D-ring analogues productively using a facile protocol. Then, a coupling of the D-rings to ring ABC produced three isotope-labelled SL derivatives. Moreover, (+)-D3-2'-epi-1A and (-)-ent-D3-2'-epi-1A with high enantiomeric purity were obtained via chiral resolution.
authors.affiliation: Institute of Applied Chemistry, East China University of Science and Technology, 130 Mei Long Road, Shanghai, 200237, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Institute of Applied Chemistry, East China University of Science and Technology, 130 Mei Long Road, Shanghai, 200237, China.
authors.forename: Wen-hui
authors.initials: WH
authors.lastname: Ding
authors.affiliation: Institute of Applied Chemistry, East China University of Science and Technology, 130 Mei Long Road, Shanghai, 200237, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Long
authors.affiliation: Institute of Applied Chemistry, East China University of Science and Technology, 130 Mei Long Road, Shanghai, 200237, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Center for Advanced materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Ling Ling Lu, Shanghai, 200032, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Center for Advanced materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Ling Ling Lu, Shanghai, 200032, China.
authors.forename: Xiao-qiang
authors.initials: XQ
authors.lastname: Li
mesh_terms: D004355:Drug Stability; D005663:Furans / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*; D007783:Lactones / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification*
chemical_list: D005663:Furans; D007783:Lactones; D019275:Radiopharmaceuticals; C039851:3-methylfuran; C483518:strigol
keywords: 3-methylfuran-2(5H)-one; 5-deoxystrigol; isotope; strigolactone