title: Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic Patients.
abstract: Thiazide diuretics (TDs) are a cost-effective first-line therapy for uncomplicated hypertension; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTaGENE project was used. Nondiabetic hypertensive participants on monotherapy for hypertension were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 hypertensive participants, 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, -1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated hypertension.
authors.affiliation: Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada.|Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
authors.forename: Cristiano S
authors.initials: CS
authors.lastname: Moura
authors.affiliation: Division of Experimental Medicine, McGill University, Montreal, QC, Canada.|Division of General Internal Medicine, McGill University, Montreal, QC, Canada.
authors.forename: Stella S
authors.initials: SS
authors.lastname: Daskalopoulou
authors.affiliation: Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.
authors.forename: Linda E
authors.initials: LE
authors.lastname: Levesque
authors.affiliation: Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada.|Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
authors.forename: Sasha
authors.initials: S
authors.lastname: Bernatsky
authors.affiliation: Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada.|Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
authors.forename: Michal
authors.initials: M
authors.lastname: Abrahamowicz
authors.affiliation: Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada.
authors.forename: Meytal A
authors.initials: MA
authors.lastname: Tsadok
authors.affiliation: Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada.
authors.forename: Shadi
authors.initials: S
authors.lastname: Rajabi
authors.affiliation: Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada.|Division of General Internal Medicine, McGill University, Montreal, QC, Canada.
authors.forename: Louise
authors.initials: L
authors.lastname: Pilote
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D049993:Sodium Chloride Symporter Inhibitors