title: Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population.
abstract: OBJECTIVE
  To assess the high-sensitivity C-reactive protein (hs-CRP) levels and explore the risk factors for an elevated hs-CRP level. We also provide the clinical utility of CRP to identify subjects with metabolic syndrome (MetS).
  
  
  METHODS
  Data were drawn from a cross-sectional survey in China. Subjects were divided into three subgroups: hs-CRP ≤ 1 mg/L, 1 mg/L < hs-CRP ≤ 3 mg/L and hs-CRP > 3 mg/L. Multiple linear regressions and logistic regression models were used.
  
  
  RESULTS
  In the Chinese population, 50.43% subjects had a low hs-CRP level, 30.21% subjects had an intermediate hs-CRP level and 19.36% subjects had an elevated hs-CRP level. Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP. In multivariate analysis, relative risks of an elevated CRP level were 2.40 (95% CI 1.44-3.99, p = 0.001), 3.63 (95% CI 2.20-5.98, p < 0.001), 4.23 (95% CI 2.51-7.11, p < 0.001) and 6.23 (95% CI 3.45-11.26, p < 0.001) for subjects with 1, 2, 3, or more than 3 MetS components, respectively. The accurate estimates of the area under the receiver operating characteristic of hs-CRP for MetS was 0.6954 (95% CI, 0.67-0.72).
  
  
  CONCLUSIONS
  Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and ACR are correlated with log-CRP. The number of MetS components is a significant determinant of elevated CRP levels after adjusted for other potential confounders.
authors.affiliation: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China. feixia_97@163.com.|Department of Nephrology, Huhhot First Hospital, Huhhot, Inner Mongolia 010010, China. feixia_97@163.com.
authors.forename: Mingxia
authors.initials: M
authors.lastname: Sun
authors.affiliation: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China. zhangliying926@126.com.|Department of Nephrology, The First Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia 010010, China. zhangliying926@126.com.
authors.forename: Liying
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China. dqydqy386@sina.com.|Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China. dqydqy386@sina.com.
authors.forename: Shanying
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China. pepsi84@163.com.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China. shaoxfei@126.com.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Shao
authors.affiliation: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China. hequnzou@hotmail.com.
authors.forename: Hequn
authors.initials: H
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology*; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D002681:China; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000208:ethnology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood; D012307:Risk Factors; D057185:Sedentary Behavior
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D002097:C-Reactive Protein
keywords: C-reactive protein; metabolic disorder