title: Correlation between LSP1 polymorphisms and the susceptibility to breast cancer.
abstract: OBJECTIVE
  The present study aimed at assessing the relationship between Leukocyte-specific protein 1 gene (LSP1) polymorphisms (rs569550 and rs592373) and the pathogenesis of breast cancer (BC).
  
  
  METHODS
  70 BC patients and 72 healthy subjects were enrolled in the study. Rs569550 and rs592373 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Odds ratio (OR) with 95% confidence interval (CI) were calculated by the chi-squared test to assess the relationship between LSP1 polymorphisms and BC risk. Linkage disequilibrium (LD) and haplotypes were also analyzed by HaploView software.
  
  
  RESULTS
  Genotype distribution of the control was in accordance with Hardy-Weinberg equilibrium (HWE). The homozygous genotype TT and T allele of rs569550 could significantly increase the risk of BC (TT vs. GG: OR=3.17, 95% CI=1.23-8.91; T vs. G: OR=1.63, 95% CI=1.01-2.64). For rs592373, mutation homozygous genotype CC and C allele were significantly associated with BC susceptibility (CC vs. TT: OR=4.45, 95% CI=1.38-14.8; C vs. T: OR=1.70, 95% CI=1.03-2.81). LD and haplotypes analysis of rs569550 and rs592373 polymorphisms showed that T-C haplotype was a risk factor for BC (T-C vs. G-T: OR=1.74, 95% CI=1.04-2.92).
  
  
  CONCLUSIONS
  LSP1 rs569550 and rs592373 polymorphisms are both risk factors for BC.
authors.affiliation: Department of Galactophore, The General Hospital of Beijing Military Command Beijing, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Galactophore, The General Hospital of Beijing Military Command Beijing, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Galactophore, The General Hospital of Beijing Military Command Beijing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Qiu
authors.affiliation: Department of Galactophore, The General Hospital of Beijing Military Command Beijing, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008840:Microfilament Proteins / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; C489183:LSP1 protein, human; D008840:Microfilament Proteins
keywords: LSP1; breast cancer; polymorphisms