title: The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean.
abstract: BACKGROUND
  The human Y-box-binding protein 1 (YB-1) is a member of the DNA/RNA-binding family of proteins that regulates transcription and translation of genes. Previous studies suggest that YB-1 may have an oncogenic role in various cancers. In this study, we evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer.
  
  
  METHODS
  Immunohistochemical staining study was performed with YB-1 using tissue block from 233 patients with invasive ductal carcinoma. Patients were divided into two groups according to expression of cytoplasmic YB-1 in tumor cell (high versus low). The relationship between the expression of YB-1, clinicopathological characteristics and breast cancer prognosis was analyzed.
  
  
  RESULTS
  Hormone receptor negativity, worse histologic and nuclear grade, high tumor stage, lymphovascular invasion and high Ki67 (≥14 %) were related with the increased expression of cytoplasmic YB-1 in tumor cell (p < 0.05). Although there was no significant difference in relapse-free survival (RFS) between the two groups (p = 0.412), difference in overall survival (OS) was statistically significant (p = 0.035). In multivariate analysis for OS, YB-1 was an independent prognostic factor (p = 0.043).
  
  
  CONCLUSIONS
  This suggests that the increased expression of cytoplasmic YB-1 in tumor cells can be regarded as an independent prognostic factor for breast cancer, related to poor prognostics. Expression of cytoplasmic YB-1 in cancer cell could be used as an independent prognostic marker for predicting OS in breast cancer.
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, College of Medicine, Busan, Korea.
authors.forename: Anbok
authors.initials: A
authors.lastname: Lee
authors.affiliation: Department of Surgery, School of Medicine, Mokdong Hospital, Ewha Womans University, Seoul, Korea.
authors.forename: Juhyun
authors.initials: J
authors.lastname: Woo
authors.affiliation: Department of Pathology, School of Medicine, Mokdong Hospital, Ewha Womans University, Seoul, Korea.
authors.forename: Heejung
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Pathology, School of Medicine, Mokdong Hospital, Ewha Womans University, Seoul, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Sung
authors.affiliation: Department of Microbiology, School of Medicine, Ewha Womans University, Seoul, Korea.
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Seoh
authors.affiliation: Department of Surgery, School of Medicine, Mokdong Hospital, Ewha Womans University, Seoul, Korea. limw@ewha.ac.kr.
authors.forename: Woosung
authors.initials: W
authors.lastname: Lim
authors.affiliation: Department of Surgery, School of Medicine, Mokdong Hospital, Ewha Womans University, Seoul, Korea. mbit@ewha.ac.kr.
authors.forename: Byung-In
authors.initials: BI
authors.lastname: Moon
mesh_terms: D000328:Adult; D044466:Asian People; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D051840:Y-Box-Binding Protein 1 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human
keywords: Breast neoplasm; Cytoplasm; Human; Prognosis; YBX1 protein