title: Role of dystrophic epidermolysis bullosa in anxiety, depression and self-esteem: A controlled cross-sectional study.
abstract: The psychological aspect in patients with dystrophic epidermolysis bullosa (DEB) is poorly documented. We sought to determine the role of DEB in anxiety, depression and self-esteem. We conducted a cross-sectional study, collecting data from 27 DEB patients and 26 healthy individuals. DEB patients and healthy controls completed three different psychometric scales for anxiety and depression and one scale for self-esteem. DEB patients and healthy controls were homogeneous for age and sex (P > 0.05), but not for employment, marital status and economic level (P < 0.05). Median values of all psychometric battery scales were not statistically significant between DEB patients and healthy controls, except for Goldberg scale for anxiety (P = 0.003) and depression (P = 0.037) and slightly significant for Zung Scale for anxiety (P = 0.048) with no difference between DEB patients with dominant versus recessive form in all scales (P > 0.05). Among DEB patients, only employment showed a significant difference in all scales (P < 0.05) but Hamilton for depression, whereas self-esteem seemed to be affected by marriage (P = 0.04) and education (P = 0.016). DEB patients apparently are not more anxious and/or depressed and do not have less self-esteem than healthy individuals.
authors.affiliation: Department of Oral Medicine, Carolinas Medical Center, Charlotte, North Carolina, USA.|D.eb.RA. Mexico Foundation, Monterrey, Nuevo Leon, Mexico.|School of Orgonomy "Piero Borrelli", Federico Navarro Institute, Naples, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Fortuna
authors.affiliation: Department of Economics and Statistics, Federico II University of Naples, Naples, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Aria
authors.affiliation: D.eb.RA. Mexico Foundation, Monterrey, Nuevo Leon, Mexico.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cepeda-Valdes
authors.affiliation: D.eb.RA. Mexico Foundation, Monterrey, Nuevo Leon, Mexico.
authors.forename: Sandra Cecilia
authors.initials: SC
authors.lastname: Garcia-Garcia
authors.affiliation: Department of Basic Science, Universidad de Monterrey, San Pedro Garza García, México.
authors.forename: Maria Guadalupe
authors.initials: MG
authors.lastname: Moreno Trevino
authors.affiliation: D.eb.RA. Mexico Foundation, Monterrey, Nuevo Leon, Mexico.|Department of Basic Science, Universidad de Monterrey, San Pedro Garza García, México.
authors.forename: Julio Cesar
authors.initials: JC
authors.lastname: Salas-Alanís
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000209:etiology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology*; D016108:Epidermolysis Bullosa Dystrophica / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D012649:Self Concept; D055815:Young Adult
keywords: anxiety; depression; epidermolysis bullosa; treatment