title: A Newly Discovered Epidemic Area of Echinococcus multilocularis in West Gansu Province in China.
abstract: Alveolar echinococcosis (AE) is a lethal parasitic disease. In Gansu Province of China, all AE cases reported in literature were from Zhang and Min Counties, the southern part of the province. Here, we report the discovery of nine AE cases and one cystic echinococcosis (CE) case from Nanfeng Town of Minle County, in the middle of Hexi Corridor in west Gansu Province. The diagnosis of these cases were confirmed by serology, histopathology, computed tomography, B-ultrasound, immunohistochemistry method, DNA polymerase chain reaction and sequencing analysis. Because eight of nine AE cases came from First Zhanglianzhuang (FZLZ) village, we conducted preliminary epidemiological analyses of 730 persons on domestic water, community and ecology such as 356 dogs' faeces of FZLZ, in comparison with those of other five villages surrounding FZLZ. Our studies indicate that Nanfeng Town of Minle County is a newly discovered focus of AE in China as a CE and AE co-epidemic area. Further research of Echinococcus multilocularis transmission pattern in the area should be carried for prevention of this parasitic disease.
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China; The Research Institute of Biomedical Nanotechnology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Genshu
authors.initials: G
authors.lastname: Bao
authors.affiliation: Department of Hepatobiliary Surgery, Ningxia People's Hospital, Yinchuan, China.
authors.forename: Duoqiang
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Zhangye People's Hospital, Zhangye, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Gao
authors.affiliation: Center for Disease Control of Minle County, Minle, China.
authors.forename: Tinjun
authors.initials: T
authors.lastname: Wu
authors.affiliation: Cestode Zoonoses Research Group, School of Environment and Life Sciences, University of Salford, Manchester, United Kingdom.
authors.forename: Philip
authors.initials: P
authors.lastname: Craig
authors.affiliation: Chrono-environment lab, University of Franche-Comté, Besançon, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Giraudoux
authors.affiliation: Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xin
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Lili
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Gen
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China; The Research Institute of Biomedical Nanotechnology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D002681:China / Q000453:epidemiology; D004285:Dogs / Q000469:parasitology*; D004443:Echinococcosis; D004444:Echinococcosis, Hepatic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000635:transmission; D048210:Echinococcus multilocularis / Q000302:isolation & purification* / Q000472:pathogenicity; D058872:Epidemics; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed