title: Efficacy of colchicine in a child with relapsing bullous Henoch-Schönlein purpura.
abstract: Colchicine is not usually considered a treatment option for cutaneous lesions of Henoch-Schönlein purpura (HSP) in children. We report a case of pediatric HSP with severe chronic and relapsing cutaneous manifestations that were resistant to corticosteroids. Colchicine had remarkable therapeutic efficacy, with positive dechallenge and rechallenge, without any adverse effects.
  
  
  CONCLUSIONS
  Colchicine should be considered for chronic, severe cutaneous lesions of pediatric HSP.
  
  
  BACKGROUND
  Colchicine is not usually considered a treatment option for cutaneous lesions of Henoch-Schönlein purpura (HSP) in children. What is New: We report a case of pediatric HSP with severe cutaneous manifestations that responded well to colchicine. Colchicine should be considered for chronic cutaneous lesions of HSP in children.
authors.affiliation: Department of General Pediatrics, Hôpital Necker-Enfants Malades, APHP, Paris Descartes University, 149 rue de Sèvres, 75015, Paris, France. slimane.allali@nck.aphp.fr.
authors.forename: Slimane
authors.initials: S
authors.lastname: Allali
authors.affiliation: Department of Pathology, Hôpital Necker-Enfants Malades, APHP, Paris Descartes University, 149 rue de Sèvres, 75015, Paris, France. sylvie.fraitag@nck.aphp.fr.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Fraitag
authors.affiliation: Department of Internal Medicine, Hôpital Cochin, APHP, Paris Descartes University, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France. benjamin.terrier@cch.aphp.fr.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Terrier
authors.affiliation: Department of Dermatology, Hôpital Necker-Enfants Malades, APHP, Paris Descartes University, 149 rue de Sèvres, 75015, Paris, France. christine.bodemer@nck.aphp.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Bodemer
authors.affiliation: Department of General Pediatrics, Hôpital Necker-Enfants Malades, APHP, Paris Descartes University, 149 rue de Sèvres, 75015, Paris, France. martin.chalumeau@nck.aphp.fr.
authors.forename: Martin
authors.initials: M
authors.lastname: Chalumeau
mesh_terms: D002675:Child, Preschool; D002908:Chronic Disease; D003078:Colchicine / Q000627:therapeutic use*; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012008:Recurrence
chemical_list: D003078:Colchicine
keywords: Chronic severe cutaneous lesions; Colchicine; Henoch-Schönlein purpura; Immunoglobulin A vasculitis; Leukocytoclastic vasculitis