title: Large-Volume Microfluidic Cell Sorting for Biomedical Applications.
abstract: Microfluidic cell-separation technologies have been studied for almost two decades, but the limited throughput has restricted their impact and range of application. Recent advances in microfluidics enable high-throughput cell sorting and separation, and this has led to various novel diagnostic and therapeutic applications that previously had been impossible to implement using microfluidics technologies. In this review, we focus on recent progress made in engineering large-volume microfluidic cell-sorting methods and the new applications enabled by them.
authors.affiliation: BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602; email: jyhan@mit.edu.|School of Mechanical and Manufacturing Engineering, Australian Centre for NanoMedicine, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Majid Ebrahimi
authors.initials: ME
authors.lastname: Warkiani
authors.affiliation: Department of Biological Engineering and.
authors.forename: Lidan
authors.initials: L
authors.lastname: Wu
authors.affiliation: BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602; email: jyhan@mit.edu.
authors.forename: Andy Kah Ping
authors.initials: AK
authors.lastname: Tay
authors.affiliation: BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602; email: jyhan@mit.edu.|Department of Biological Engineering and.|Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Jongyoon
authors.initials: J
authors.lastname: Han
mesh_terms: D001698:Biomedical Engineering; D032701:Biomimetics; D001803:Blood Transfusion; D002453:Cell Cycle; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D002498:Centrifugation / Q000379:methods; D004867:Equipment Design; D057166:High-Throughput Screening Assays / Q000295:instrumentation / Q000379:methods; D006801:Humans; D057446:Hydrodynamics; D007688:Kidneys, Artificial; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D057725:Operative Blood Salvage; D018805:Sepsis / Q000097:blood / Q000628:therapy
keywords: blood transfusion; cell sorting; circulating cancer cells; high-throughput; inertial; large-volume microfluidic; separation; sepsis