title: Neuroleptic Malignant Syndrome: A Case Aimed at Raising Clinical Awareness.
abstract: A 60-year-old man with a history of bipolar disorder on risperidone, bupropion, and escitalopram was admitted for community acquired streptococcal pneumonia. Four days later, he developed persistent hyperthermia, dysautonomia, rigidity, hyporeflexia, and marked elevation of serum creatine phosphokinase. He was diagnosed with neuroleptic malignant syndrome (NMS) and improved with dantrolene, bromocriptine, and supportive therapy. This case emphasizes the importance of considering a broad differential diagnosis for fever in the ICU, carefully reviewing the medication list for all patients, and considering NMS in patients with fever and rigidity.
authors.affiliation: Department of Internal Medicine, Thomas Jefferson University Hospital, 1025 Walnut Street, Jefferson College Building, Suite 805, Philadelphia, PA 19107, USA.
authors.forename: Jad
authors.initials: J
authors.lastname: Al Danaf
authors.affiliation: Department of Internal Medicine, Thomas Jefferson University Hospital, 1025 Walnut Street, Jefferson College Building, Suite 805, Philadelphia, PA 19107, USA.
authors.forename: John
authors.initials: J
authors.lastname: Madara
authors.affiliation: Department of Internal Medicine, Thomas Jefferson University Hospital, 1025 Walnut Street, Jefferson College Building, Suite 805, Philadelphia, PA 19107, USA.
authors.forename: Caitlin
authors.initials: C
authors.lastname: Dietsche