title: Acid-Sensitive Nanogels for Synergistic Chemo-Photodynamic Therapy.
abstract: Herein, a novel kind of intelligent nanogels have been designed, which can spatiotemporally control the release of drug (doxorubicin) and photosensitizers (porphyrins) to combine chemo-therapy and photodynamic therapy. Further, the fluorescing properties of porphyrins make it possible to be used as a kind of diagnostic bio-imaging agents. In vitro release assays confirm that DOX-loaded nanogels show obvious intracellular pH-sensitive property. The intracellular experiments further prove that drug-loaded nanogels has the significantly antitumor efficacy due to the combination of chemotherapy and photodynamic therapy, which made this drug delivery system hold great potential applications for further cancer treatment.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China. chenl686@nenu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005782:Gels; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010778:Photochemotherapy / Q000379:methods*; D011166:Porphyrins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D011166:Porphyrins; D004317:Doxorubicin
keywords: bio-imaging; dextran; drug delivery; pH-responsiveness; synergistic therapy