title: The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats.
abstract: The aim of the present study was to investigate the possible protective effects of boron, an antioxidant agent, against arsenic-induced oxidative stress in male and female rats. In total, 42 Wistar albino male and female rats were divided into three equal groups: The animals in the control group were given normal drinking water, the second group was given drinking water with 100 mg/L arsenic, and the third group was orally administered drinking water with 100 mg/kg boron together with arsenic. At the end of the 28-day experiment, arsenic increased lipid peroxidation and damage in the tissues of rats. However, boron treatment reversed this arsenic-induced lipid peroxidation and activities of antioxidant enzymes in rats. Moreover, boron exhibited a protective action against arsenic-induced histopathological changes in the tissues of rats. In conclusion, boron was found to be effective in protecting rats against arsenic-induced lipid peroxidation by enhancing antioxidant defense mechanisms.
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03030, Afyonkarahisar, Turkey. kurt@aku.edu.tr.
authors.forename: Ismail
authors.initials: I
authors.lastname: Kucukkurt
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03030, Afyonkarahisar, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Ince
authors.affiliation: Bayat Vocational School, Afyon Kocatepe University, Bayat Afyonkarahisar, Turkey.
authors.forename: Hasan Huseyin
authors.initials: HH
authors.lastname: Demirel
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03030, Afyonkarahisar, Turkey.
authors.forename: Ruhi
authors.initials: R
authors.lastname: Turkmen
authors.affiliation: Usak Health Training School, Usak University, 64200, Usak, Turkey.
authors.forename: Erten
authors.initials: E
authors.lastname: Akbel
authors.affiliation: Afyon Health Training School, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Celik
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001151:Arsenic / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001895:Boron / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D006454:Hemoglobins; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D001151:Arsenic; D001895:Boron
keywords: Antioxidant Enzymes; Arsenic: Boron; Lipid Peroxidation; Rat