title: Modulating reconsolidation: a link to causal systems-level dynamics of human memories.
abstract: A vital property of the brain is its plasticity, which manifests as changes in behavioral performance. Invasive studies at the cellular level in animal models reveal time-restricted windows during which existing memories that are reactivated become susceptible to modification through reconsolidation, and evidence suggests similar effects in humans. In this review we summarize recent work utilizing noninvasive brain stimulation in humans to uncover the systems-level mechanisms underlying memory reconsolidation. This novel understanding of memory dynamics may have far-reaching clinical implications, including the potential to modulate reconsolidation in patients with memory disorders.
authors.affiliation: Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA; Human Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Sandrini
authors.affiliation: Human Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
authors.forename: Leonardo G
authors.initials: LG
authors.lastname: Cohen
authors.affiliation: School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: censornitzan@post.tau.ac.il.
authors.forename: Nitzan
authors.initials: N
authors.lastname: Censor
mesh_terms: D001921:Brain / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology; D006801:Humans; D008568:Memory / Q000502:physiology*
keywords: TMS; episodic; memory; motor skill; noninvasive brain stimulation; tDCS