title: Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems.
abstract: A nanocarrier-integrated bottom-up method is a promising strategy for advanced drug-release systems. Self-assembled nanogels, which are one of the most beneficial nanocarriers for drug-delivery systems, are tectonically integrated to prepare nanogel-crosslinked (NanoClik) microspheres. NanoClik microspheres consisting of nanogel-derived structures (observed by STED microscopy) release "drug-loaded nanogels" after hydrolysis, resulting in successful sustained drug delivery in vivo.
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.|Japan Science and Technology Agency (JST), The Exploratory Research for Advanced Technology (ERATO), Bio-Nanotransporter Project, Katsura Int'tech Center, Katsura, Nishikyo-ku, Kyoto, 615-8530, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Tahara
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.|Japan Science and Technology Agency (JST), The Exploratory Research for Advanced Technology (ERATO), Bio-Nanotransporter Project, Katsura Int'tech Center, Katsura, Nishikyo-ku, Kyoto, 615-8530, Japan.
authors.forename: Sada-Atsu
authors.initials: SA
authors.lastname: Mukai
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.|Japan Science and Technology Agency (JST), The Exploratory Research for Advanced Technology (ERATO), Bio-Nanotransporter Project, Katsura Int'tech Center, Katsura, Nishikyo-ku, Kyoto, 615-8530, Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Sawada
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sasaki
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.|Japan Science and Technology Agency (JST), The Exploratory Research for Advanced Technology (ERATO), Bio-Nanotransporter Project, Katsura Int'tech Center, Katsura, Nishikyo-ku, Kyoto, 615-8530, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Akiyoshi
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004355:Drug Stability; D004738:Engineering; D020100:Hydrogels / Q000737:chemistry*; D007267:Injections; D051379:Mice; D008863:Microspheres; D008958:Models, Molecular; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D020100:Hydrogels
keywords: drug delivery; microspheres; nanogels; polysaccharides; proteins