title: Preeclampsia in twin pregnancies: association with selective intrauterine growth restriction.
abstract: OBJECTIVE
  To identify the association between preeclampsia (PE) and selective intrauterine growth restriction (sIUGR) in twin pregnancies.
  
  
  METHODS
  This was a retrospective cohort study of 1004 twin pregnancies from 2008 to 2014. We specifically compared the incidence, clinical characteristics and outcomes of PE between sIUGR and normal-growth twin pregnancies.
  
  
  RESULTS
  PE occurred more frequently in sIUGR pregnancies [29.0% (51/176)] than in normal-growth twin pregnancies [13.1% (99/756), p < 0.001, adjusted odds ratio 3.29]. Among sIUGR, the incidence of PE was significantly higher in dichorionic (DC) pregnancies (37.5%, 30/80) than in monochorionic (MC) pregnancies (21.9%, 21/96). The rates of onset at <32 weeks (p = 0.045) and of severe PE (p = 0.025) were higher in sIUGR pregnancies with PE. The systolic blood pressure was also higher in sIUGR pregnancies with PE (152.6 ± 11.8 mmHg) than in normal-growth pregnancies with PE (148.0 ± 8.2 mmHg) (p = 0.042). Additionally, more sIUGR pregnancies were delivered at 32-36 weeks (p = 0.001), and fewer were delivered at ≥36 weeks (p < 0.001). Moreover, the prevalence of severe neonatal asphyxia was higher in sIUGR pregnancies with PE than in normal-growth pregnancies with PE (8.8% versus 2.5%, p = 0.020).
  
  
  CONCLUSIONS
  sIUGR is associated with increased odds of developing severe PE in twin pregnancies, leading to poorer perinatal outcomes.
authors.affiliation: a Fetal Medicine Center, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , People's Republic of China.
authors.forename: Dongcai
authors.initials: D
authors.lastname: Wu
authors.affiliation: a Fetal Medicine Center, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , People's Republic of China.
authors.forename: Linhuan
authors.initials: L
authors.lastname: Huang
authors.affiliation: a Fetal Medicine Center, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , People's Republic of China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: He
authors.affiliation: a Fetal Medicine Center, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Huang
authors.affiliation: a Fetal Medicine Center, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , People's Republic of China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Fang
authors.affiliation: a Fetal Medicine Center, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , People's Republic of China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Luo
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D006801:Humans; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D059285:Pregnancy, Twin / Q000706:statistics & numerical data*; D012189:Retrospective Studies
keywords: Preeclampsia; selective intrauterine growth restriction; twin pregnancies