title: T-helper 22 cells as a new player in chronic inflammatory skin disorders.
abstract: T-helper 22 (Th22) cell is a new subset of CD4+ T cells that secrets interleukin (IL)-22 but not IL-17 or interferon-γ. Th22 is distinct from Th17 and other known CD4+ T-cell subsets with distinguished gene expression and function. Th22 subsets have chemokine receptors CCR6+ CCR4+ CCR10+ phenotype and aryl hydrocarbon receptor as the key transcription factor. This T-helper subset, by producing cytokines such as IL-22, IL-13, and tumor necrosis factor-α, is implicated in the pathogenesis of inflammatory skin disorder. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis.
authors.affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirshafiey
authors.affiliation: Karolinska Institutet Science Park AB, Huddinge, Sweden.
authors.forename: Anita
authors.initials: A
authors.lastname: Simhag
authors.affiliation: Department of Histology, Dubai Medical College, Dubai, UAE.
authors.forename: Nadia M M
authors.initials: NM
authors.lastname: El Rouby
authors.affiliation: Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.|Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Azizi
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D011565:Psoriasis / Q000276:immunology*; D012867:Skin / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D000097043:Interleukin-22