title: Health benefits of anthocyanins and molecular mechanisms: Update from recent decade.
abstract: Anthocyanins are one of the most widespread families of natural pigments in the plant kingdom. Their health beneficial effects have been documented in many in vivo and in vitro studies. This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms. It appears that several signaling pathways, including mitogen-activated protein kinase, nuclear factor κB, AMP-activated protein kinase, and Wnt/β-catenin, as well as some crucial cellular processes, such as cell cycle, apoptosis, autophagy, and biochemical metabolism, are involved in these beneficial effects and may provide potential therapeutic targets and strategies for the improvement of a wide range of diseases in future. In addition, specific anthocyanin metabolites contributing to the observed in vivo biological activities, structure-activity relationships as well as additive and synergistic efficacy of anthocyanins are also discussed.
authors.affiliation: a College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, and Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University , Beijing , China.
authors.forename: Daotong
authors.initials: D
authors.lastname: Li
authors.affiliation: a College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, and Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University , Beijing , China.
authors.forename: Pengpu
authors.initials: P
authors.lastname: Wang
authors.affiliation: b Department of Nutrition and Food Science , University of Maryland , College Park , Maryland , USA.
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Luo
authors.affiliation: a College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, and Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University , Beijing , China.
authors.forename: Mengyao
authors.initials: M
authors.lastname: Zhao
authors.affiliation: a College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, and Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University , Beijing , China.
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
mesh_terms: D000872:Anthocyanins / Q000737:chemistry* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis; D001343:Autophagy; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002453:Cell Cycle; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction
chemical_list: D000872:Anthocyanins; D000893:Anti-Inflammatory Agents; D019440:Anti-Obesity Agents; D000970:Antineoplastic Agents; D007004:Hypoglycemic Agents; D018696:Neuroprotective Agents
keywords: Anthocyanins; anti-cancer activity; anti-inflammation activity; benefits; mechanism; neuroprotective activity