title: Animal Models of Corneal Injury.
abstract: The cornea is an excellent model system to use for the analysis of wound repair because of its accessibility, lack of vascularization, and simple anatomy. Corneal injuries may involve only the superficial epithelial layer or may penetrate deeper to involve both the epithelial and stromal layers. Here we describe two well-establishedin vivocorneal wound models: a mechanical wound model that allows for the study of re-epithelialization and a chemical wound model that may be used to study stromal activation in response to injury (Steppet al., 2014; Carlsonet al., 2003).
authors.affiliation: Francis I. Proctor Foundation, University of California, San Francisco, USA ; Department of Ophthalmology, University of California, San Francisco, USA.
authors.forename: Matilda F
authors.initials: MF
authors.lastname: Chan
authors.affiliation: Department of Anatomy, University of California, San Francisco, USA.
authors.forename: Zena
authors.initials: Z
authors.lastname: Werb