title: Machine-Assisted Organic Synthesis.
abstract: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors. In the rapidly changing, multivariant environment of the research laboratory, equipment needs to be modular to accommodate high and low temperatures and pressures, enzymes, multiphase systems, slurries, gases, and organometallic compounds. Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods. All of these areas create both opportunities and challenges during adoption as enabling technologies.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK).
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Fitzpatrick
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK).
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Myers
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK).
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK).
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ingham
mesh_terms: D001709:Biotechnology / Q000379:methods*; D060326:Chemistry Techniques, Synthetic; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances
keywords: machine-assisted synthesis; sustainable chemistry; synthetic methods