title: Comparison of toxicity of class-based organic chemicals to algae and fish based on discrimination of excess toxicity from baseline level.
abstract: Toxicity data to fish and algae were used to investigate excess toxicity between species. Results show that chemicals exhibiting excess toxicity to fish also show excess toxicity to algae for most of the compounds. This indicates that they share the same mode of action between species. Similar relationships between logKOW and toxicities to fish and algae for baseline and less inert compounds suggest that they have similar critical body residues in the two species. Differences in excess toxicity for some compounds suggest that there is a difference of physiological structure and metabolism between fish and algae. Some reactive compounds (e.g. polyamines) exhibit greater toxic effects for algae than those for fish because of relatively low bio-uptake potential of these hydrophilic compounds in fish as compared with that in algae. Esters exhibiting greater toxicity in fish than that in algae indicate that metabolism can affect the discrimination of excess toxicity from baseline level. Algae growth inhibition is a very good surrogate for fish lethality. This is not only because overall toxicity sensitivity to algae is greater than that to fish, but also the excess toxicity calculated from algal toxicity can better reflect reactivity of compounds with target molecules than fish toxicity.
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Jin J
authors.initials: JJ
authors.lastname: Li
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Hong W
authors.initials: HW
authors.lastname: Tai
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wen
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Xiao H
authors.initials: XH
authors.lastname: Wang
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China. Electronic address: zhaoyh@nenu.edu.cn.
authors.forename: Yuan H
authors.initials: YH
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000460:Chlorophyta / Q000187:drug effects*; D005399:Fishes; D009930:Organic Chemicals / Q000633:toxicity*; D013045:Species Specificity
chemical_list: D009930:Organic Chemicals
keywords: Algae; Excess toxicity; Fish; Hydrophobicity; Interspecies correlation; Toxic mechanism