title: Platelet activation after endovascular repair of abdominal aortic aneurysm.
abstract: OBJECTIVE
  To investigate the effect of endovascular aneurysm repair (EVAR) on platelet (PLT) function and reveal possible associated factors.
  
  
  METHODS
  Fifty consecutive patients were included. PLT count and activation (CD62P-CD36), white blood cell (WBC) count, and high sensitivity C-reactive protein (hs-CRP) were measured preoperatively, at the first and third postoperative day.
  
  
  RESULTS
  EVAR elicited a significant reduction in PLT count from baseline to first day after EVAR (p < 0.001), while no significant difference was noted between the first and third day. Furthermore, CD62P expression was markedly elevated at the first day after EVAR (median % positive PLTs from 13.7 at baseline to 22.1, p = 0.05), but returned to baseline levels by the third day. Maximum abdominal aortic aneurysm diameter was the only factor that significantly affected the CD62P values (p = 0.005). Postoperative CD36 values were significantly correlated with total aneurysm volume (p = 0.05) and were higher in endografts made from polyester (p = 0.01). There were no correlation between PLT activation and hs-CRP, WBC, maximum temperature, and 30-day morbidity.
  
  
  CONCLUSIONS
  EVAR has elucidated a significant reduction in PLT count and increase in PLT activation at the immediate postoperative period. The type of the endograft material and the aneurysm maximum diameter and volume appear to play an important role in PLT activation.
authors.affiliation: Department of Anesthesiology, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Arnaoutoglou
authors.affiliation: Department of Surgery, Vascular Surgery Unit, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Kouvelos
authors.affiliation: Department of Surgery, Vascular Surgery Unit, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: Nektario
authors.initials: N
authors.lastname: Papa
authors.affiliation: Laboratory of Haematology, Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece.
authors.forename: Achilleas
authors.initials: A
authors.lastname: Karamoutsios
authors.affiliation: Department of Surgery, Vascular Surgery Unit, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Bouris
authors.affiliation: Laboratory of Haematology, Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Vartholomatos
authors.affiliation: Department of Surgery, Vascular Surgery Unit, Medical School, University of Ioannina, Ioannina, Greece mimats@cc.uoi.gr.
authors.forename: Miltiadis
authors.initials: M
authors.lastname: Matsagkas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D001027:Aortography / Q000379:methods; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D002097:C-Reactive Protein / Q000378:metabolism; D018955:CD36 Antigens / Q000097:blood; D000072226:Computed Tomography Angiography; D057510:Endovascular Procedures / Q000009:adverse effects* / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D010979:Platelet Function Tests; D011446:Prospective Studies; D011474:Prosthesis Design; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018955:CD36 Antigens; D019007:P-Selectin; C546937:SELP protein, human; D002097:C-Reactive Protein
keywords: Platelets; activation; aneurysm; endovascular; endovascular aneurysm repair