title: Markers of bone metabolism, serum leptin levels and bone mineral density in preterm babies.
abstract: The prospective study assessed the influence of serum leptin levels on markers of bone metabolism and bone mineral density in 2-year-old infants born preterm. A total of 57 randomized preterm Caucasian newborns (32nd-37th week of gestation) were included in the study. Bone metabolism markers were measured every 6 months. The infants were monitored prospectively up to the age of 2 years. When the infants turned 2 years of age, they were investigated by dual energy X-ray absorptiometry (lumbar spine). The median cord blood leptin levels was 3.07 μg/L. The median leptin level during check-ups before 2 years of age was 9.96 μg/L. The other laboratory markers were within the normal ranges for that age. The bone mineral density reached, on average, 0.410 g/cm2. Lower leptin levels in the cord blood and in the serum of preterm infants do not influence bone mineral density during the first 2 years of life.
authors.forename: Petra Kanioková
authors.initials: PK
authors.lastname: Veselá
authors.forename: Radek
authors.initials: R
authors.lastname: Kaniok
authors.forename: Milan
authors.initials: M
authors.lastname: Bayer
mesh_terms: D015502:Absorptiometry, Photon; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000175:diagnosis*; D001842:Bone and Bones / Q000378:metabolism*; D002675:Child, Preschool; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D020738:Leptin / Q000097:blood*; D008297:Male; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D020738:Leptin