title: Comparative Study on Serum Levels of 10 Trace Elements in Schizophrenia.
abstract: The etiology and pathophysiology of schizophrenia remain obscure. This study explored the associations between schizophrenia risk and serum levels of 10 trace elements. A 1:1 matched case-control study was conducted and matched by age and sex. Blood samples were collected to determine the concentrations of nickel, molybdenum, arsenic, aluminum, chromium, manganese, selenium, copper, iron and zinc by an inductively coupled plasma-mass spectrometry. The conditional logistic regression model was used to analyze the associations between trace elements and schizophrenia risk. Totally 114 schizophrenia patients and 114 healthy controls were recruited in the study. The multivariate analysis demonstrated that copper≤0.97 μg/mL, selenium≤72 ng/mL and manganese>3.95 ng/mL were associated with an increased risk of schizophrenia. The study showed that lower levels of selenium, copper and higher levels of manganese were found in schizophrenia patients compared with healthy controls.
authors.affiliation: School of Public Health, Peking University, Beijing, People's Republic of China; Civil Aviation Medicine Center, Civil Aviation Administration of China, Beijing, People's Republic of China.
authors.forename: Tiebing
authors.initials: T
authors.lastname: Liu
authors.affiliation: School of Public Health, Peking University, Beijing, People's Republic of China.
authors.forename: Qing-Bin
authors.initials: QB
authors.lastname: Lu
authors.affiliation: School of Public Health, Peking University, Beijing, People's Republic of China.
authors.forename: Lailai
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Clinical Laboratory, PLA 261st Hospital, Beijing, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Clinical Laboratory, PLA 261st Hospital, Beijing, People's Republic of China.
authors.forename: Fangbo
authors.initials: F
authors.lastname: Feng
authors.affiliation: Department of Clinical Laboratory, PLA 261st Hospital, Beijing, People's Republic of China.
authors.forename: Jinyun
authors.initials: J
authors.lastname: Qiu
authors.affiliation: School of Public Health, Peking University, Beijing, People's Republic of China.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012559:Schizophrenia / Q000097:blood*; D014131:Trace Elements / Q000097:blood*
chemical_list: D014131:Trace Elements