title: Clinical significance of the prenatal double bubble sign - single institution experience.
abstract: OBJECTIVE
  The objective of this study is to determine the risk of aneuploidy, associated structural anomalies, and pregnancy outcome in the presence of prenatal double bubble sign detection.
  
  
  METHODS
  We have performed a retrospective study on ultrasound reports and pregnancy outcomes in 42 fetuses with double bubble sign examined in our ultrasound department between 1998 and 2013.
  
  
  RESULTS
  Additional major defects or aneuploidy markers were present in 24 fetuses. Chromosomal abnormalities occurred in 21 cases. There were 35 live births; two pregnancies ended in intrauterine fetal demise; five patients opted for termination of pregnancy because of additional anomalies or abnormal karyotype. Postnatal or postmortem verification revealed duodenal obstruction secondary to intrinsic or extrinsic cause in 40 cases; in one case, proximal jejunal atresia was diagnosed, and one neonate had normal bowel.
  
  
  CONCLUSIONS
  Sonographic double bubble sign is associated with a significant rate of major anatomic defects, abnormal karyotype, and unfavorable pregnancy outcome. It is strongly indicative of duodenal obstruction.
authors.affiliation: Clinic of Obstetrics and Gynecology, Professor Witold Orłowski Independent Public Clinical Hospital - Postgraduate Medical Education Centre, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Kucińska-Chahwan
authors.affiliation: Clinic of Obstetrics and Gynecology, Professor Witold Orłowski Independent Public Clinical Hospital - Postgraduate Medical Education Centre, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Posiewka
authors.affiliation: Clinic of Obstetrics and Gynecology, Professor Witold Orłowski Independent Public Clinical Hospital - Postgraduate Medical Education Centre, Warsaw, Poland.
authors.forename: Julia
authors.initials: J
authors.lastname: Bijok
authors.affiliation: Clinic of Obstetrics and Gynecology, Professor Witold Orłowski Independent Public Clinical Hospital - Postgraduate Medical Education Centre, Warsaw, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Jakiel
authors.affiliation: Clinic of Obstetrics and Gynecology, Professor Witold Orłowski Independent Public Clinical Hospital - Postgraduate Medical Education Centre, Warsaw, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Roszkowski
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging* / Q000453:epidemiology; D004380:Duodenal Obstruction / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D055815:Young Adult