title: Synthesis, Characterization, and Application of Core-Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents.
abstract: Multimodal nanoparticulate materials are described, offering magnetic, radionuclide, and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography/single-photon emission commuted tomography (PET/SPECT), and optical imaging. They comprise Fe3O4@NaYF4 core/shell nanoparticles (NPs) with different cation dopants in the shell or core, including Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm). These NPs are stabilized by bisphosphonate polyethylene glycol conjugates (BP-PEG), and then show a high transverse relaxivity (r2) up to 326 mM(-1) s(-1) at 3T, a high affinity to [(18)F]-fluoride or radiometal-bisphosphonate conjugates (e.g., (64)Cu and (99m)Tc), and fluorescent emissions from 500 to 800 nm under excitation at 980 nm. The biodistribution of intravenously administered particles determined by PET/MR imaging suggests that negatively charged Co0.16Fe2.84O4@NaYF4(Yb, Er)-BP-PEG (10K) NPs cleared from the blood pool more slowly than positively charged NPs Fe3O4@NaYF4(Yb, Tm)-BP-PEG (2K). Preliminary results in sentinel lymph node imaging in mice indicate the advantages of multimodal imaging.
authors.affiliation: King's College London , Division of Imaging Sciences and Biomedical Engineering, Fourth Floor Lambeth Wing, St. Thomas Hospital, London, SE1 7EH, United Kingdom.
authors.forename: Xianjin
authors.initials: X
authors.lastname: Cui
authors.affiliation: CROmed Ltd. Baross u. 91-95, H-1047, Budapest, Hungary.
authors.forename: Domokos
authors.initials: D
authors.lastname: Mathe
authors.affiliation: CROmed Ltd. Baross u. 91-95, H-1047, Budapest, Hungary.
authors.forename: Noémi
authors.initials: N
authors.lastname: Kovács
authors.affiliation: Department of Biophysics and Radiation Biology, Semmelweis University , IX. Tűzoltó u. 37-47, H-1094, Budapest, Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Horváth
authors.affiliation: King's College London , Division of Imaging Sciences and Biomedical Engineering, Fourth Floor Lambeth Wing, St. Thomas Hospital, London, SE1 7EH, United Kingdom.
authors.forename: Maite
authors.initials: M
authors.lastname: Jauregui-Osoro
authors.affiliation: King's College London , Division of Imaging Sciences and Biomedical Engineering, Fourth Floor Lambeth Wing, St. Thomas Hospital, London, SE1 7EH, United Kingdom.|King's College London , Division of Chemistry, Britannia House, 7 Trinity St., London, SE1 1DB, United Kingdom.
authors.forename: Rafael
authors.initials: R
authors.lastname: Torres Martin de Rosales
authors.affiliation: King's College London , Division of Imaging Sciences and Biomedical Engineering, Fourth Floor Lambeth Wing, St. Thomas Hospital, London, SE1 7EH, United Kingdom.
authors.forename: Gregory E D
authors.initials: GE
authors.lastname: Mullen
authors.affiliation: MRC Centre for Transplantation, King's College London , Guys Hospital, London, SE1 9RT, United Kingdom.
authors.forename: Wilson
authors.initials: W
authors.lastname: Wong
authors.affiliation: School of Chemistry, Nottingham University , Nottingham, NG7 2RD, U.K.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yan
authors.affiliation: King's College London , Division of Imaging Sciences and Biomedical Engineering, Fourth Floor Lambeth Wing, St. Thomas Hospital, London, SE1 7EH, United Kingdom.
authors.forename: Dirk
authors.initials: D
authors.lastname: Krüger
authors.affiliation: School of Chemistry, Nottingham University , Nottingham, NG7 2RD, U.K.
authors.forename: Andrei N
authors.initials: AN
authors.lastname: Khlobystov
authors.affiliation: School of Chemistry, Nottingham University , Nottingham, NG7 2RD, U.K.
authors.forename: Maria
authors.initials: M
authors.lastname: Gimenez-Lopez
authors.affiliation: CROmed Ltd. Baross u. 91-95, H-1047, Budapest, Hungary.
authors.forename: Mariann
authors.initials: M
authors.lastname: Semjeni
authors.affiliation: Department of Biophysics and Radiation Biology, Semmelweis University , IX. Tűzoltó u. 37-47, H-1094, Budapest, Hungary.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Szigeti
authors.affiliation: Department of Biophysics and Radiation Biology, Semmelweis University , IX. Tűzoltó u. 37-47, H-1094, Budapest, Hungary.
authors.forename: Dániel S
authors.initials: DS
authors.lastname: Veres
authors.affiliation: School of Physics and Astronomy, Queen Mary University of London , Mile End Road, London, E1 4NS, United Kingdom.
authors.forename: Haizhou
authors.initials: H
authors.lastname: Lu
authors.affiliation: Dpto. CITIMAC, Universidad de Cantabria , Avda. Los Castros, s/n 39005, Santander, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Hernández
authors.affiliation: School of Physics and Astronomy, Queen Mary University of London , Mile End Road, London, E1 4NS, United Kingdom.
authors.forename: William P
authors.initials: WP
authors.lastname: Gillin
authors.affiliation: King's College London , Division of Imaging Sciences and Biomedical Engineering, Fourth Floor Lambeth Wing, St. Thomas Hospital, London, SE1 7EH, United Kingdom.
authors.forename: Andrea
authors.initials: A
authors.lastname: Protti
authors.affiliation: Department of Biophysics and Radiation Biology, Semmelweis University , IX. Tűzoltó u. 37-47, H-1094, Budapest, Hungary.
authors.forename: Katalin Kis
authors.initials: KK
authors.lastname: Petik
authors.affiliation: King's College London , Division of Imaging Sciences and Biomedical Engineering, Fourth Floor Lambeth Wing, St. Thomas Hospital, London, SE1 7EH, United Kingdom.|King's College London , Division of Chemistry, Britannia House, 7 Trinity St., London, SE1 1DB, United Kingdom.|King's College London , Department of Physics, Strand Campus, London, WC2R 2LS, United Kingdom.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Green
authors.affiliation: King's College London , Division of Imaging Sciences and Biomedical Engineering, Fourth Floor Lambeth Wing, St. Thomas Hospital, London, SE1 7EH, United Kingdom.|King's College London , Division of Chemistry, Britannia House, 7 Trinity St., London, SE1 1DB, United Kingdom.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Blower
mesh_terms: D000818:Animals; D004164:Diphosphonates / Q000737:chemistry / Q000493:pharmacokinetics; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000493:pharmacokinetics; D005459:Fluorides / Q000737:chemistry* / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D064847:Multimodal Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D061848:Optical Imaging / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D015019:Yttrium / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D004164:Diphosphonates; C525362:sodium yttriumtetrafluoride; D011092:Polyethylene Glycols; D015019:Yttrium; D005459:Fluorides; D052203:Ferrosoferric Oxide