title: Venlafaxine induced QTc interval prolongation in a therapeutic dose.
abstract: This is the second report of a patient developing severe prolongation of QTc interval with a dose of 300mg/day of venlafaxine; on stopping it, QTc reverted to normalcy. Venlafaxine was restarted and maintained at 150mg/day, with QTc interval remaining normal, indicating, that it has a dose-dependent effect on QTc interval. Venlafaxine was not changed as she had responded best to this drug compared to any other antidepressant. Over 20 years, the only time she had a period of 5 years of remission, was when she was on 75mg of venlafaxine/day.
authors.affiliation: Department of Psychiatry, Rajarajeswari Medical College & Hospital, Bangalore 560074, India. Electronic address: amar.bavle@gmail.com.
authors.forename: Amar
authors.initials: A
authors.lastname: Bavle
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects*; D000069470:Venlafaxine Hydrochloride / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D000068760:Serotonin and Noradrenaline Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride
keywords: Prolonged QTc; Torsade de pointes; Venlafaxine