title: A Review: Proteomics in Nasopharyngeal Carcinoma.
abstract: Although radiotherapy is generally effective in the treatment of major nasopharyngeal carcinoma (NPC), this treatment still makes approximately 20% of patients radioresistant. Therefore, the identification of blood or biopsy biomarkers that can predict the treatment response to radioresistance and that can diagnosis early stages of NPC would be highly useful to improve this situation. Proteomics is widely used in NPC for searching biomarkers and comparing differentially expressed proteins. In this review, an overview of proteomics with different samples related to NPC and common proteomics methods was made. In conclusion, identical proteins are sorted as follows: Keratin is ranked the highest followed by such proteins as annexin, heat shock protein, 14-3-3σ, nm-23 protein, cathepsin, heterogeneous nuclear ribonucleoproteins, enolase, triosephosphate isomerase, stathmin, prohibitin, and vimentin. This ranking indicates that these proteins may be NPC-related proteins and have potential value for further studies.
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University and Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China. chenzetan@163.com.|Key Laboratories of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning 530021, China. chenzetan@163.com.
authors.forename: Ze-Tan
authors.initials: ZT
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University and Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China. zhongguoliang1989@126.com.|Key Laboratories of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning 530021, China. zhongguoliang1989@126.com.
authors.forename: Zhong-Guo
authors.initials: ZG
authors.lastname: Liang
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University and Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China. zhuxdonggxmu@126.com.|Key Laboratories of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning 530021, China. zhuxdonggxmu@126.com.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology*; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D014408:Biomarkers, Tumor
keywords: NPC (nasopharyngeal carcinoma); biomarker; differentially expressed proteins; mass spectrometry; nasopharyngeal carcinoma; proteomics; two-dimensional electrophoresis