title: Comparison of Avena sativa, vinegar, and hydroxyzine for uremic pruritus of hemodialysis patients: a crossover randomized clinical trial.
abstract: BACKGROUND
  Uremic pruritus is a common complication in patients with chronic kidney disease. While its cause is not known for certain, different treatments are currently applied. This study aimed to compare the effects of Avena sativa, diluted vinegar, and hydroxyzine on the reduction of uremic pruritus.
  
  
  METHODS
  In this crossover randomized clinical trial, 23 hemodialysis patients with uremic pruritus were randomly divided into 3 groups. The first group was treated with Avena sativa lotion, twice a day, for as long as 2 weeks; the second group received diluted vinegar; and the third group took hydroxyzine tablets for the same time span. After 3-day-long washout periods, the therapeutic methods were crossed over. The data were collected by a pruritus scale and a visual analogue scale, which were completed before and after the interventions.
  
  
  RESULTS
  Avena sativa lotion significantly decreased the mean scores of pruritus intensity, consequences, and the verbal descriptor, although it did not have a significant effect on the frequency of pruritus and the pruritic surface. Vinegar and hydroxyzine significantly decreased all of the scores.  Conclusions. Avena sativa, vinegar, and hydroxyzine were effective in decreasing pruritus. Diluted vinegar and Avena sativa can be used as a complement to hydroxyzine, which is itself a common pharmaceutical therapy.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Nakhaee
authors.affiliation: Health Qualitative Research Center, Birjand University of Medical Sciences, Birjand, Iran. nasiri2006@bums.ac.ir.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Nasiri
authors.forename: Yadollah
authors.initials: Y
authors.lastname: Waghei
authors.forename: Jamileh
authors.initials: J
authors.lastname: Morshedi
mesh_terms: D019342:Acetic Acid / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D018554:Avena; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011537:Pruritus / Q000188:drug therapy*; D006435:Renal Dialysis / Q000009:adverse effects; D014511:Uremia / Q000150:complications / Q000628:therapy*
chemical_list: D006919:Hydroxyzine; D019342:Acetic Acid