title: Impact of EGFR and p53 expressions on survival and quality of life in locally advanced oral squamous cell carcinoma patients treated with chemoradiation.
abstract: EGFR and p53 are molecular markers which play important role in tumor progression and development. The objective of this study was to assess the association between EGFR and p53 expression and survival, and to determine whether EGFR and p53 expression levels were associated with differences quality of life in OSCC patients undergoing chemoradiation. A total of 120 OSCC patients aged 20-67 y and stage III/IV were recruited. Treatment response was assessed according to W.H.O. (1979). EGFR and p53 expression in tumor tissue was estimated by immunohistochemical (IHC) method and quantified as percentage positive nuclei. Molecular marker expressions of both EGFR and p53 were found significantly (P < 0.01 or P < 0.001) associated with overall response, survivals and quality of life. Neither EGFR nor p53 expression was associated with hematologic or non-hematologic toxicity. EGFR and p53 molecular marker expressions may have significant association with survival and QOL in OSCC patients undergoing chemoradiation.
authors.affiliation: a Department of Radiotherapy ; King George's Medical University ; Lucknow , UP , India.
authors.forename: Seema
authors.initials: S
authors.lastname: Gupta
authors.affiliation: a Department of Radiotherapy ; King George's Medical University ; Lucknow , UP , India.
authors.forename: Huma
authors.initials: H
authors.lastname: Khan
authors.affiliation: a Department of Radiotherapy ; King George's Medical University ; Lucknow , UP , India.
authors.forename: Vandana Singh
authors.initials: VS
authors.lastname: Kushwaha
authors.affiliation: b Department of Pathology ; RMLIMS ; Lucknow , UP , India.
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
authors.affiliation: c Clinical and Experimental Medicine Division; CSIR-Central Drug Research Institute ; Lucknow , UP , India.
authors.forename: Mps
authors.initials: M
authors.lastname: Negi
authors.affiliation: c Clinical and Experimental Medicine Division; CSIR-Central Drug Research Institute ; Lucknow , UP , India.
authors.forename: Ashim
authors.initials: A
authors.lastname: Ghatak
authors.affiliation: a Department of Radiotherapy ; King George's Medical University ; Lucknow , UP , India.
authors.forename: Mlb
authors.initials: M
authors.lastname: Bhatt
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D059248:Chemoradiotherapy; D015331:Cohort Studies; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D018307:Neoplasms, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D016016:Proportional Hazards Models; D011788:Quality of Life; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: chemoradition; immunohistochemistry; oral squamous cell carcinoma; quality of life; survival endpoints; toxicity