title: First-episode psychosis is associated with oxidative stress: Effects of short-term antipsychotic treatment.
abstract: OBJECTIVE
  In the present study, our aim was to investigate the oxidative-antioxidative systems in unmedicated first-episode psychosis (FEP) patients at the beginning and after short-term treatment.
  
  
  METHODS
  This study consisted of 29 patients who experienced an FEP and 25 control subjects. In order to investigate the oxidative status, we determined plasma malondialdehyde (MDA) levels, oxidizability of red blood cells, oxidation and oxidizability of apolipoprotein B-containing lipoproteins (apo B-basal MDA and apo B-ΔMDA). In order to evaluate the antioxidative defense, we measured serum total antioxidative capacity, uric acid, albumin, total bilirubin and vitamin E levels and serum paraoxonase/arylesterase, whole blood glutathione peroxidase (GPx) and red blood cell superoxide dismutase activities before and after 6 weeks of treatment in patients with FEP.
  
  
  RESULTS
  Plasma MDA and apo B-basal MDA levels and red blood cell superoxide dismutase activity were significantly higher and serum arylesterase and whole blood-GPx activities were lower in the FEP group than those of the healthy control group. There were not any significant changes in the oxidative and antioxidative system parameters (except increased vitamin E levels) after treatment.
  
  
  CONCLUSIONS
  The results of this study suggest that FEP is accompanied by oxidative stress. However, further studies are needed to clarify the role of oxidative stress in the physiopathologic mechanisms of FEP, so that oxidative and antioxidative system parameters can be used in the management of these patients. In accordance with psychiatric evaluation, for a better management, patients with FEP may require a multidisciplinary approach, including oxidative and antioxidative system parameters.
authors.affiliation: Departments of Psychiatry.
authors.forename: Asli
authors.initials: A
authors.lastname: Sarandol
authors.affiliation: Clinical Biochemistry, Uludag University Medical Faculty, Bursa, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Sarandol
authors.affiliation: Clinical Biochemistry, Uludag University Medical Faculty, Bursa, Turkey.
authors.forename: Hacer Ebru
authors.initials: HE
authors.lastname: Acikgoz
authors.affiliation: Departments of Psychiatry.
authors.forename: Salih Saygin
authors.initials: SS
authors.lastname: Eker
authors.affiliation: Departments of Psychiatry.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Akkaya
authors.affiliation: Clinical Biochemistry, Uludag University Medical Faculty, Bursa, Turkey.
authors.forename: Melehat
authors.initials: M
authors.lastname: Dirican
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D053299:Apolipoprotein B-100 / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D016022:Case-Control Studies; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D011618:Psychotic Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism; D000075462:Serum Albumin, Human; D013482:Superoxide Dismutase / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood; D055815:Young Adult
chemical_list: C422455:ALB protein, human; C569471:APOB protein, human; D014150:Antipsychotic Agents; D053299:Apolipoprotein B-100; D012709:Serum Albumin; D014810:Vitamin E; D014527:Uric Acid; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; D001663:Bilirubin; D000075462:Serum Albumin, Human
keywords: affective disorders; antioxidant; first-episode psychosis; oxidative stress; schizophrenia