title: RIT2 rs12456492 polymorphism and the risk of Parkinson's disease: A meta-analysis.
abstract: Many published case-control studies have investigated the association between rs12456492(A/G) variant in RIT2 gene and the risk of Parkinson's disease(PD); however, an ambiguous conclusion remains elusive. Our aim was to evaluate the association of RIT2 rs12456492(A/G) polymorphism with the risk of PD. We searched the Pubmed, Science Direct, EMBASE and EBSCO databases up to May 2015 for related studies. A total of 5 studies with 2541 PD cases and 2531 controls were included in the meta-analysis based on the strict inclusion and exclusion criteria. STATA 12.0 statistics software was used to calculate available data from each study. The pooled odds ratios (OR) and 95% confidence interval (CI) were calculated to assess the genetic association between RIT2 rs12456492 polymorphism and the risk of PD. There is a significant association between rs12456492 and PD (Gvs.A:OR=1.024, 95%CI:1.112-1.303, P=0.001; GGvs.AA:OR=1.486, 95%CI:1.259-1.755, P=0.001; GAvs.AA:OR=1.217, 95%CI:1.071-1.383, P=0.003; GG+GAvs.AA:OR=1.290, 95%CI:1.143-1.455, P=0.001; GGvs.GA+AA:OR=1.262, 95%CI:1.097-1.451, P=0.001). The data of our meta-analysis indicates that the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of PD.
authors.affiliation: Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Mengyue
authors.initials: M
authors.lastname: Niu
authors.affiliation: Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: xieanmu@163.com.
authors.forename: Anmu
authors.initials: A
authors.lastname: Xie
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D020559:Monomeric GTP-Binding Proteins; C583559:RiT2 protein, human
keywords: Gene polymorphism; Meta-analysis; Parkinson’s disease