title: Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation.
abstract: This review presents recent evidence implicating microRNAs (miRNAs) in the beneficial effects of resveratrol (trihydroxystilbene), a nonflavonoid plant polyphenol, with emphasis on its anti-inflammatory effects. Many diseases and pathologies have been linked, directly or indirectly, to inflammation. These include infections, injuries, atherosclerosis, diabetes mellitus, obesity, cancer, osteoarthritis, age-related macular degeneration, demyelination, and neurodegenerative diseases. Resveratrol can both decrease the secretion of proinflammatory cytokines (e.g., IL-6, IL-8, and TNF-α) and increase the production of anti-inflammatory cytokines; it also decreases the expression of adhesion proteins (e.g., ICAM-1) and leukocyte chemoattractants (e.g., MCP-1). Resveratrol's primary targets appear to be the transcription factors AP-1 and NF-κB, as well as the gene COX2. Although no mechanistic link between any particular miRNA and resveratrol has been identified, resveratrol effects depend at least in part upon the modification of the expression of a variety of miRNAs that can be anti-inflammatory (e.g., miR-663), proinflammatory (e.g., miR-155), tumor suppressing (e.g., miR-663), or oncogenic (e.g., miR-21).
authors.affiliation: Laboratoire Bio-PeroxIL, Université de Bourgogne, Dijon, France.
authors.forename: Norbert
authors.initials: N
authors.lastname: Latruffe
authors.affiliation: Laboratoire Bio-PeroxIL, Université de Bourgogne, Dijon, France.
authors.forename: Allan
authors.initials: A
authors.lastname: Lançon
authors.affiliation: Department of Research and Statistics, Translational Research Laboratory, IRCCS Arcispedale S.Maria Nuova, Reggio Emilia, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Frazzi
authors.affiliation: Laboratoire Bio-PeroxIL, Université de Bourgogne, Dijon, France.|INSERM UMR 866, Dijon, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Aires
authors.affiliation: Laboratoire Bio-PeroxIL, Université de Bourgogne, Dijon, France.|INSERM UMR 866, Dijon, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Delmas
authors.affiliation: Laboratoire Bio-PeroxIL, Université de Bourgogne, Dijon, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Michaille
authors.affiliation: INSERM U1124, Université Paris Descartes, Paris, France.
authors.forename: Fatima
authors.initials: F
authors.lastname: Djouadi
authors.affiliation: INSERM U1124, Université Paris Descartes, Paris, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Bastin
authors.affiliation: Laboratoire Bio-PeroxIL, Université de Bourgogne, Dijon, France.
authors.forename: Mustapha
authors.initials: M
authors.lastname: Cherkaoui-Malki
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001095:Arachidonic Acids / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D035683:MicroRNAs / Q000502:physiology*; D034622:RNA Interference; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D018836:Inflammation Mediators; D035683:MicroRNAs; D013267:Stilbenes; D000077185:Resveratrol
keywords: inflammation; miRNAs; regulation; resveratrol