title: N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma.
abstract: OBJECTIVE
  To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma.
  
  
  METHODS
  N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points.
  
  
  RESULTS
  N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events.
  
  
  CONCLUSIONS
  Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.
authors.affiliation: Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anne K
authors.initials: AK
authors.lastname: Mylin
authors.affiliation: Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jens P
authors.initials: JP
authors.lastname: Goetze
authors.affiliation: Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Heickendorff
authors.affiliation: Division of Hematology, Linköping University Hospital, Linköping, Sweden.
authors.forename: Lucia
authors.initials: L
authors.lastname: Ahlberg
authors.affiliation: Section of Hematology, TromsøUniversity Hospital, Tromsø, Norway.
authors.forename: Inger Marie
authors.initials: IM
authors.lastname: Dahl
authors.affiliation: Department of Hematology, Odense University Hospital, Odense, Denmark.
authors.forename: Niels
authors.initials: N
authors.lastname: Abildgaard
authors.affiliation: Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Gimsing
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D001847:Bone Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood; D011859:Radiography
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; D020098:Natriuretic Peptide, C-Type
keywords: CNP; bone disease; multiple myeloma; natriuretic peptides; renal impairment