title: 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1.
abstract: 2'-5'-Oligoadenylate synthetase-like protein (OASL) is an interferon-inducible antiviral protein. Here we describe differential inhibitory activities of human OASL and the two mouse OASL homologs against respiratory syncytial virus (RSV) replication. Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteasome-dependent degradation of specific OASL isoforms. We conclude that OASL acts as a cellular antiviral protein and that RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.
authors.affiliation: Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA.
authors.forename: Jayeeta
authors.initials: J
authors.lastname: Dhar
authors.affiliation: Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Rolando A
authors.initials: RA
authors.lastname: Cuevas
authors.affiliation: Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA.
authors.forename: Ramansu
authors.initials: R
authors.lastname: Goswami
authors.affiliation: Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA saumen@pitt.edu s.barik@csuohio.edu.
authors.forename: Saumendra N
authors.initials: SN
authors.lastname: Sarkar
authors.affiliation: Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA saumen@pitt.edu s.barik@csuohio.edu.
authors.forename: Sailen
authors.initials: S
authors.lastname: Barik
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000276:immunology / Q000502:physiology*; D000818:Animals; D057809:HEK293 Cells; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007111:Immunity, Cellular; D051379:Mice; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D059748:Proteolysis; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000502:physiology*; D014779:Virus Replication / Q000276:immunology / Q000502:physiology*
chemical_list: C512343:NS2 protein, human respiratory syncytial virus; D017361:Viral Nonstructural Proteins; C115020:OASL protein, human; C475083:Oasl1 protein, mouse; C475084:Oasl2 protein, mouse; D015088:2',5'-Oligoadenylate Synthetase; D046988:Proteasome Endopeptidase Complex