title: A new diketopiperazine derivative from a deep sea-derived Streptomyces sp. SCSIO 04496.
abstract: A new diketopiperazine (DKP) derivative, (6R,3Z)-3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione (1), as well as five known DKPs 2-6 was isolated from a deep sea-derived Streptomyces sp. SCSIO 04496. The structure of 1 was elucidated using a combination of 1D and 2D NMR, HR-ESI-MS and chiral-phase HPLC techniques. Compounds 1-6 did not show cytotoxic activity at a concentration of 100 μM in bioactivity assay.
authors.affiliation: a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing 400042 , P.R. China.|b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Minghe
authors.initials: M
authors.lastname: Luo
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Guiling
authors.initials: G
authors.lastname: Tang
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ju
authors.affiliation: a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing 400042 , P.R. China.
authors.forename: Laichun
authors.initials: L
authors.lastname: Lu
authors.affiliation: b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Huang
mesh_terms: D001597:Benzylidene Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D054659:Diketopiperazines / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009792:Oceans and Seas; D010879:Piperazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification; D014871:Water Microbiology
chemical_list: C000609493:3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione; D001597:Benzylidene Compounds; D054659:Diketopiperazines; D010879:Piperazines
keywords: Streptomyces sp.; cyclodipeptide; diketopiperazine