title: Structural and genetic diversity in antibody repertoires from diverse species.
abstract: The antibody repertoire is the fundamental unit that enables development of antigen specific adaptive immune responses against pathogens. Different species have developed diverse genetic and structural strategies to create their respective antibody repertoires. Here we review the shark, chicken, camel, and cow repertoires as unique examples of structural and genetic diversity. Given the enormous importance of antibodies in medicine and biological research, the novel properties of these antibody repertoires may enable discovery or engineering of antibodies from these non-human species against difficult or important epitopes.
authors.affiliation: Fabrus Inc., A Division of Sevion Therapeutics, San Diego, CA 92121, United States.
authors.forename: Miguel
authors.initials: M
authors.lastname: de los Rios
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United States.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Criscitiello
authors.affiliation: Fabrus Inc., A Division of Sevion Therapeutics, San Diego, CA 92121, United States; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
authors.forename: Vaughn V
authors.initials: VV
authors.lastname: Smider
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000737:chemistry* / Q000235:genetics*; D002162:Camelus / Q000235:genetics; D002417:Cattle / Q000235:genetics; D002645:Chickens / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012754:Sharks / Q000235:genetics
chemical_list: D000906:Antibodies