title: Eosinophilic gastroenteritis in a patient with chronic hepatitis C who received treatment with pegylated interferon.
abstract: A 54-year-old male was treated for chronic hepatitis C with pegylated interferon (PEG-IFN) α-2a administered for 24 weeks. HCV-RNA was negative at 24 weeks after treatment, showing sustained virological response (SVR). Abdominal distention and diarrhea were observed 28 weeks after commencing the treatment, i.e., 4 weeks after completing treatment. The elevation of eosinophil count was observed in blood tests and ascites, and because eosinophilic infiltration was also observed on gastrointestinal histopathology, the patient was diagnosed with eosinophilic enteritis. As the eosinophil count spontaneously improved and abdominal symptoms disappeared, the patient was not treated with steroids. The onset of eosinophilic enteritis during interferon therapy is comparatively rare. In this case, PEG-IFN was considered to be the causative factor. Furthermore, we suggested that subserosal eosinophilic enteritis may have characteristic symptoms in patients having hepatic diseases treated with interferon.
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan. g.hirano@minf.med.fukuoka-u.ac.jp.
authors.forename: Genryu
authors.initials: G
authors.lastname: Hirano
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fukunaga
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sohda
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Kunimoto
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yotsumoto
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Sakurai
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Iwashita
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.|The Division of Advanced Clinical Research for Viral Hepatitis and Liver Cancer, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ueda
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Yokoyama
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.|The Division of Advanced Clinical Research for Viral Hepatitis and Liver Cancer, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Morihara
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tomioka
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Anan
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Takeyama
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Eguchi
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.|The Division of Advanced Clinical Research for Viral Hepatitis and Liver Cancer, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Sakamoto
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Irie
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Iwata
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shakado
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Aoyagi
authors.affiliation: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.|The Division of Advanced Clinical Research for Viral Hepatitis and Liver Cancer, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Sakisaka
keywords: Chronic hepatitis C; Eosinophilic gastroenteritis; Pegylated interferon (PEG-IFN); Predominant subserosal layer disease