title: Consecutive Food and Respiratory Allergies Amplify Systemic and Gut but Not Lung Outcomes in Mice.
abstract: Epidemiological data suggest a link between food allergies and the subsequent development of asthma. Although this progression may result from the additional effects of exposure to multiple allergens, whether both allergies amplify each other's effects remains unknown. This study investigated whether oral exposure to food allergens influences the outcomes of subsequent respiratory exposure to an asthma-inducing allergen. Mice were sensitized and orally challenged with wheat (FA) and then exposed to house dust mite (HDM) extract (RA). Immunoglobulin (Ig), histamine, and cytokine levels were assayed by ELISA. Intestinal and lung physiology was assessed. Ig levels, histamine release, and cytokine secretion were higher after exposure to both allergens than after separate exposure to each. Intestinal permeability was higher, although airway hyper-responsiveness and lung inflammation remained unchanged. Exposure to food and respiratory allergens amplifies systemic and gut allergy-related immune responses without any additional effect on lung function and inflammation.
authors.affiliation: †INRA, UR1268 BIA, rue de la géraudière, B.P. 71627, F-44316 Nantes, France.
authors.forename: Gregory
authors.initials: G
authors.lastname: Bouchaud
authors.affiliation: †INRA, UR1268 BIA, rue de la géraudière, B.P. 71627, F-44316 Nantes, France.
authors.forename: Paxcal
authors.initials: P
authors.lastname: Gourbeyre
authors.affiliation: ‡INSERM, UMR1087, l'institut du thorax, F-44000 Nantes, France.|#CNRS, UMR 6291, F-44000 Nantes, France.|⊥Université de Nantes, F-44000 Nantes, France.|ΔCHU Nantes, l'institut du thorax, Service de pneumologie, F-44000 Nantes, France.|ΠDHU2020 médecine personnalisée des maladies chroniques, F-44100 Nantes, France.
authors.forename: Tiphaine
authors.initials: T
authors.lastname: Bihouée
authors.affiliation: ⊥Université de Nantes, F-44000 Nantes, France.|ΠDHU2020 médecine personnalisée des maladies chroniques, F-44100 Nantes, France.|⊗INSERM UMR S 913, Institut des Maladies de l'Appareil Digestif (IMAD), Faculté de Médecine, F-44000 Nantes, France.
authors.forename: Phillippe
authors.initials: P
authors.lastname: Aubert
authors.affiliation: ‡INSERM, UMR1087, l'institut du thorax, F-44000 Nantes, France.|#CNRS, UMR 6291, F-44000 Nantes, France.|⊥Université de Nantes, F-44000 Nantes, France.|ΔCHU Nantes, l'institut du thorax, Service de pneumologie, F-44000 Nantes, France.|ΠDHU2020 médecine personnalisée des maladies chroniques, F-44100 Nantes, France.
authors.forename: David
authors.initials: D
authors.lastname: Lair
authors.affiliation: ‡INSERM, UMR1087, l'institut du thorax, F-44000 Nantes, France.|#CNRS, UMR 6291, F-44000 Nantes, France.|⊥Université de Nantes, F-44000 Nantes, France.|ΔCHU Nantes, l'institut du thorax, Service de pneumologie, F-44000 Nantes, France.|ΠDHU2020 médecine personnalisée des maladies chroniques, F-44100 Nantes, France.
authors.forename: Marie-Aude
authors.initials: MA
authors.lastname: Cheminant
authors.affiliation: †INRA, UR1268 BIA, rue de la géraudière, B.P. 71627, F-44316 Nantes, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Denery-Papini
authors.affiliation: ⊥Université de Nantes, F-44000 Nantes, France.|ΠDHU2020 médecine personnalisée des maladies chroniques, F-44100 Nantes, France.|⊗INSERM UMR S 913, Institut des Maladies de l'Appareil Digestif (IMAD), Faculté de Médecine, F-44000 Nantes, France.|ΓCHU Nantes, Institut des Maladies de l'Appareil Digestif (IMAD), F-44000 Nantes, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Neunlist
authors.affiliation: ‡INSERM, UMR1087, l'institut du thorax, F-44000 Nantes, France.|#CNRS, UMR 6291, F-44000 Nantes, France.|⊥Université de Nantes, F-44000 Nantes, France.|ΔCHU Nantes, l'institut du thorax, Service de pneumologie, F-44000 Nantes, France.|ΠDHU2020 médecine personnalisée des maladies chroniques, F-44100 Nantes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Magnan
authors.affiliation: †INRA, UR1268 BIA, rue de la géraudière, B.P. 71627, F-44316 Nantes, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Bodinier
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000276:immunology*; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D005512:Food Hypersensitivity / Q000150:complications* / Q000276:immunology*; D006632:Histamine / Q000097:blood; D007136:Immunoglobulins / Q000097:blood; D008168:Lung; D008221:Lymphoid Tissue / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D039981:Pyroglyphidae / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000276:immunology; D012137:Respiratory System / Q000166:cytology / Q000276:immunology; D014908:Triticum / Q000276:immunology
chemical_list: D000485:Allergens; D016207:Cytokines; D007136:Immunoglobulins; D006632:Histamine
keywords: T-cells; allergy; asthma; cytokines; gut; house dust mite; immunity; mouse; wheat