title: Cellular angiofibroma in women: a review of the literature.
abstract: Cellular Angiofibroma (CA) represents a quite recently described mesenchymal tumour that occurs in both genders, in particular in the vulvo-vaginal region in women and in the inguino-scrotal area in men. The first description of this tumour dates from Nucci et al. article in 1997; since then, the literature reports different reviews and case report of this tumour in both genders, but no article specifically addressing CA treatment and follow-up in women. In this review we collected all 79 published female CA cases, analyzing the clinical, pathological and immunohistochemical features of the tumour.CA affects women mostly during the fifth decade of life, it is generally a small and asymptomatic mass that mainly arises in the vulvo-vaginal region, although there are reported pelvic and extra-pelvic cases. The treatment requires a simple local excision due to an extremely low ability to recurrent locally and no chance to metastasize. Throughout the immunohistochemical and pathological findings it is also easily possible a differential diagnosis from the other soft tissue tumours which affect the vulvo-vaginal area, such as spindle cell lipoma, solitary fibrous tumour, angiomyofibroblastoma and aggressive angiomyxoma.
authors.affiliation: Unit of Obstetrics and Gynecology, IRCCS-Arcispedale S. Maria Nuova di Reggio Emilia, Viale Risorgimento n 80, Reggio Emilia, Italy.
authors.forename: Vincenzo Dario
authors.initials: VD
authors.lastname: Mandato
authors.affiliation: Unit of Obstetrics and Gynecology, IRCCS-Arcispedale S. Maria Nuova di Reggio Emilia, Viale Risorgimento n 80, Reggio Emilia, Italy. susanna.santagni@asmn.re.it.
authors.forename: Susanna
authors.initials: S
authors.lastname: Santagni
authors.affiliation: Unit of Pathology, IRCCS-Arcispedale S. Maria Nuova di Reggio Emilia, Reggio Emilia, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
authors.affiliation: Unit of Obstetrics and Gynecology, IRCCS-Arcispedale S. Maria Nuova di Reggio Emilia, Viale Risorgimento n 80, Reggio Emilia, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Aguzzoli
authors.affiliation: Unit of Obstetrics and Gynecology, IRCCS-Arcispedale S. Maria Nuova di Reggio Emilia, Viale Risorgimento n 80, Reggio Emilia, Italy.
authors.forename: Martino
authors.initials: M
authors.lastname: Abrate
authors.affiliation: Unit of Obstetrics and Gynecology, IRCCS-Arcispedale S. Maria Nuova di Reggio Emilia, Viale Risorgimento n 80, Reggio Emilia, Italy.|Unit of Obstetrics and Gynecology, University of Modena e Reggio Emilia, Reggio Emilia, Italy.
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: La Sala
mesh_terms: D018322:Angiofibroma / Q000473:pathology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology*; D006801:Humans; D012983:Soft Tissue Neoplasms / Q000473:pathology*