title: Drug Delivery Nanocarriers from a Fully Degradable PEG-Conjugated Polyester with a Reduction-Responsive Backbone.
abstract: The remarkably high intracellular concentration of reducing agents is an excellent endogenous stimulus for designing nanocarriers programmed for intracellular delivery of therapeutic agents. However, despite their excellent biodegradability profiles, aliphatic polyesters that are fully degradable in response to the intracellular reducing environment are rare. Herein, a reduction-responsive drug delivery nanocarrier derived from a linear polyester bearing disulfide bonds is reported. The reduction-responsive polyester is synthesized via a convenient polycondensation process. After conjugation of terminal carboxylic acid groups of polyester to polyethylene glycol (PEG), the resulting polymer self-assembles into nanoparticles that are capable of encapsulating dye and anticancer drug molecules. The reduction-responsive nanoparticles display a fast payload release rate in response to the intracellular reducing environment, which translates into superior anticancer activity towards PC-3 cells.
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesiology Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 (USA) http://farokhzad.bwh.harvard.edu/
authors.forename: Basit
authors.initials: B
authors.lastname: Yameen
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesiology Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 (USA) http://farokhzad.bwh.harvard.edu/|Universidad Andres Bello, Facultad de Medicina, Center for Integrative Medicine and Innovative Science (CIMIS), Echaurren 183, Santiago 8370071 (Chile).
authors.forename: Cristian
authors.initials: C
authors.lastname: Vilos
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesiology Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 (USA) http://farokhzad.bwh.harvard.edu/
authors.forename: Won Il
authors.initials: WI
authors.lastname: Choi
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesiology Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 (USA) http://farokhzad.bwh.harvard.edu/|Univerity of Waterloo, 200 University Avenue West Waterloo, ON, N2L 3G1 (Canada).
authors.forename: Andrew
authors.initials: A
authors.lastname: Whyte
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesiology Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 (USA) http://farokhzad.bwh.harvard.edu/|Univerity of Waterloo, 200 University Avenue West Waterloo, ON, N2L 3G1 (Canada).
authors.forename: Jining
authors.initials: J
authors.lastname: Huang
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesiology Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 (USA) http://farokhzad.bwh.harvard.edu/|Univerity of Waterloo, 200 University Avenue West Waterloo, ON, N2L 3G1 (Canada).
authors.forename: Lori
authors.initials: L
authors.lastname: Pollit
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesiology Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 (USA) http://farokhzad.bwh.harvard.edu/. ofarokhzad@zeus.bwh.harvard.edu.|King Abdulaziz University, Jeddah 21589 (Saudi Arabia). ofarokhzad@zeus.bwh.harvard.edu.
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D008297:Male; D053758:Nanoparticles / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D011092:Polyethylene Glycols
keywords: bioreducible polyester; cancer; cytotoxicity; drug delivery; nanomedicine