title: A Highly Responsive Silicon Nanowire/Amplifier MOSFET Hybrid Biosensor.
abstract: This study demonstrates a hybrid biosensor comprised of a silicon nanowire (SiNW) integrated with an amplifier MOSFET to improve the current response of field-effect-transistor (FET)-based biosensors. The hybrid biosensor is fabricated using conventional CMOS technology, which has the potential advantage of high density and low noise performance. The biosensor shows a current response of 5.74 decades per pH for pH detection, which is 2.5 × 10(5) times larger than that of a single SiNW sensor. In addition, we demonstrate charged polymer detection using the biosensor, with a high current change of 4.5 × 10(5) with a 500 nM concentration of poly(allylamine hydrochloride). In addition, we demonstrate a wide dynamic range can be obtained by adjusting the liquid gate voltage. We expect that this biosensor will be advantageous and practical for biosensor applications which requires lower noise, high speed, and high density.
authors.affiliation: 1] School of Electrical Engineering, Kookmin University, Seoul 136-702, Republic of Korea [2] Department of Electrical Engineering, Yale University, New Haven, Connecticut 06511, United States.
authors.forename: Jieun
authors.initials: J
authors.lastname: Lee
authors.affiliation: School of Electrical Engineering, Kookmin University, Seoul 136-702, Republic of Korea.
authors.forename: Jaeman
authors.initials: J
authors.lastname: Jang
authors.affiliation: School of Electrical Engineering, Kookmin University, Seoul 136-702, Republic of Korea.
authors.forename: Bongsik
authors.initials: B
authors.lastname: Choi
authors.affiliation: School of Electrical Engineering, Kookmin University, Seoul 136-702, Republic of Korea.
authors.forename: Jinsu
authors.initials: J
authors.lastname: Yoon
authors.affiliation: Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors.forename: Jee-Yeon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors.forename: Yang-Kyu
authors.initials: YK
authors.lastname: Choi
authors.affiliation: School of Electrical Engineering, Kookmin University, Seoul 136-702, Republic of Korea.
authors.forename: Dong Myong
authors.initials: DM
authors.lastname: Kim
authors.affiliation: School of Electrical Engineering, Kookmin University, Seoul 136-702, Republic of Korea.
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Kim
authors.affiliation: School of Electrical Engineering, Kookmin University, Seoul 136-702, Republic of Korea.
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: Choi
mesh_terms: D000669:Amplifiers, Electronic; D015374:Biosensing Techniques / Q000379:methods; D053770:Nanowires / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012825:Silicon / Q000737:chemistry*; D014173:Transistors, Electronic
chemical_list: D011108:Polymers; D012825:Silicon