title: Exfoliated Tumor Cells in Intraluminal Lavage Samples after Colorectal Endoscopic Submucosal Dissection: A Pilot Study.
abstract: Endoscopic submucosal dissection involves dissecting manipulation performed with tumors in an exposed condition for a long period of time. Thus, there is a risk for implantation of tumor cells. The objectives of this study were to examine exfoliated tumor cells after colorectal endoscopic submucosal dissection and to elucidate the effectiveness of intraluminal lavage to remove these cells. The subjects were 8 patients who had undergone colorectal endoscopic submucosal dissection at our hospital between September and December 2012. A retrospective study was conducted on the cytological findings of intraluminal lavage samples in these patients. Seven of the 8 patients (88%) had exfoliated tumor cells in the lavage samples at the beginning of lavage. Only 3 patients (3 8%) had exfoliated tumor cells after lavage with 300 ml of water. A large number of tumor cells were thought to have exfoliated into the intestinal lumen after endoscopic submucosal dissection. Sufficient intraluminal lavage after colorectal endoscopic submucosal dissection is necessary to remove exfoliated tumor cells.
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
authors.forename: Hisao
authors.initials: H
authors.lastname: Fujii
authors.forename: Fumikazu
authors.initials: F
authors.lastname: Koyama
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Uchimoto
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ueda
authors.forename: Naoto
authors.initials: N
authors.lastname: Nishigori
authors.forename: Keijirou
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Obara
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakamoto
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy / Q000009:adverse effects* / Q000379:methods; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D004210:Dissection / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000601:surgery*; D007564:Japan; D008297:Male; D008875:Middle Aged; D009366:Neoplasm Seeding; D010865:Pilot Projects; D012189:Retrospective Studies; D007507:Therapeutic Irrigation; D016896:Treatment Outcome