title: Long-term survival after resection of brain metastases from esophagogastric junction adenocarcinoma: report of two cases and review of the literature.
abstract: The prognosis for brain metastasis from primary esophageal or gastric cancer is often poor because of late detection and a lack of effective treatments. We encountered two cases of long-term survival after resection of brain metastasis that was detected >1 year after primary esophagogastric junction adenocarcinoma resection. Both patients underwent total gastrectomy, middle to lower esophagectomy, and Roux-en-Y reconstruction using the jejunum, and intrathoracic anastomosis was performed via right thoracotomy and laparotomy for primary tumor resection as well as brain metastasis resection followed by CyberKnife irradiation. They remained recurrence free-one remains alive after 6.5 years, while the other died of myocardial infarction 4 years after surgery. The present cases emphasize that long-term survival in patients with brain metastasis from gastric cancer can be expected after resection and stereotactic radiosurgery of brain metastasis detected >1 year after the resection of primary gastric adenocarcinoma.
authors.affiliation: Department of Surgery, Jikeikai Nishida Hospital, 2-266, Tsuruoka Nishimachi, Saiki-shi, Oita, 876-0047, Japan, mmandmacgyver@yahoo.co.jp.
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Matsunaga
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Wada
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Daa
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Harada
authors.forename: Kazuki
authors.initials: K
authors.lastname: Okamura
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery*; D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D004943:Esophagogastric Junction; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D013997:Time Factors