title: Bilateral Acute Proptosis as Initial Manifestation of Acute Myeloid Leukemia.
abstract: The myeloid sarcoma is an extramedullary finding of acute myeloid leukemia (AML), and orbital leukemic tumors occur most commonly during the first decade of life. To our knowledge, we report the youngest patient with bilateral proptosis of both eyes as an initial manifestation of AML. This case highlights the need for peripheral blood smear and neuro-image work-up for acute proptosis in infancy. AML should be considered in the differential diagnosis of an orbital mass, even in the absence of typical leukemic symptoms.
authors.affiliation: a Department of Ophthalmology , Changhua Christian Hospital , Changhua , Taiwan .
authors.forename: Ya-Chi
authors.initials: YC
authors.lastname: Huang
authors.affiliation: b Pediatric Hematology/Oncology, Changhua Christian Hospital , Changhua , Taiwan , and.
authors.forename: Shih-Chung
authors.initials: SC
authors.lastname: Wang
authors.affiliation: a Department of Ophthalmology , Changhua Christian Hospital , Changhua , Taiwan .|c School of Medicine, Chung Shan Medical University , Taichung City , Taiwan.
authors.forename: San-Ni
authors.initials: SN
authors.lastname: Chen
authors.affiliation: a Department of Ophthalmology , Changhua Christian Hospital , Changhua , Taiwan .
authors.forename: Jieh-Ren
authors.initials: JR
authors.lastname: Jou
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D005094:Exophthalmos / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: Acute myeloid leukemia; myeloid sarcoma; orbital mass; proptosis