title: Synthesis and Characterization of pH-Responsive Copolypeptides Vesicles for siRNA and Chemotherapeutic Drug Co-Delivery.
abstract: Novel diblock copolypeptides are synthesized and evaluated as a pH-sensitive drug delivery vector for anticancer drugs and siRNA co-delivery. The synthetic process involve the ring opening polymerization of α-amino acid N-carboxyanhydrides as well as aminolysis and deprotection reactions, and the structures are characterized. The copolypeptides can self-assemble into stable vesicles at neutral pH, and disassemble in acidic endosomal/lysosomal, which shown the pH-responsive behavior. The cell uptake results indicated that the vesicles can co-deliver DOX and siRNA inside the same cell and exhibit a pH-sensitive release behavior. Therefore, the novel polymeric vesicles are a promising carrier for co-delivery anticancer drug and siRNA to overcome the drug resistance and enhance cancer treatment.
authors.affiliation: People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China.
authors.forename: Zhanrong
authors.initials: Z
authors.lastname: Li
authors.affiliation: People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China. lijingguo@mail.zzu.edu.cn.|PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China. lijingguo@mail.zzu.edu.cn.
authors.forename: Jingguo
authors.initials: J
authors.lastname: Li
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Huang
authors.affiliation: People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China. chengdu@mail.sysu.edu.cn.
authors.forename: Du
authors.initials: D
authors.lastname: Cheng
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China.
authors.forename: Xintao
authors.initials: X
authors.lastname: Shuai
mesh_terms: D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D010455:Peptides; D034741:RNA, Small Interfering
keywords: co-delivery; copolypeptide; pH-responsive; polymersome; vesicles