title: Iridium-Catalyzed Direct C-H Sulfamidation of Aryl Nitrones with Sulfonyl Azides at Room Temperature.
abstract: Ir(III)-catalyzed direct C-H sulfamidation of aryl nitrones has been developed to synthesize various sulfamidated nitrones in moderate to excellent yields with excellent regioselectivity and broad functional group tolerance. This transformation could proceed smoothly at room temperature with low catalyst loading in the absence of external oxidants, acids, or bases. Molecular nitrogen was released as the sole byproduct, thus providing an environmentally benign sulfamidation process. And this protocol could efficiently apply to synthesize the substituted benzisoxazoline via one-step transformation from the product.
authors.affiliation: †College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Pi
authors.affiliation: †College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, P. R. China.|‡School of Biomedical Sciences, Engineering Research Centre of Molecular Medicine of Chinese Education Ministry, Xiamen Key Laboratory of Ocean and Gene Drugs, Institute of Molecular Medicine of Huaqiao University, Xiamen 361021, Fujian, P. R. China.
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
authors.affiliation: †College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, P. R. China.
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Wu
mesh_terms: D001386:Azides / Q000737:chemistry*; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006860:Hydrogen Bonding; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013696:Temperature
chemical_list: D001386:Azides; D001583:Benzoxazoles; D009589:Nitrogen Oxides; D013438:Sulfhydryl Compounds; C015388:nitrones; D007495:Iridium