title: Association between Diverticular Disease and Pre-Neoplastic Colorectal Lesions in an Urban African-American Population.
abstract: BACKGROUND
  It is unclear whether there is a shared pathway in the development of diverticular disease (DD) and potentially neoplastic colorectal lesions since both diseases are found in similar age groups and populations.
  
  
  OBJECTIVE
  To determine the association between DD and colorectal pre-neoplastic lesions in an African-American urban population.
  
  
  METHODS
  Data from 1986 patients who underwent colonoscopy at the Howard University Hospital from January 2012 through December 2012 were analyzed for this study. The presence of diverticula and polyps was recorded using colonoscopy reports. Polyps were further classified into adenoma or hyperplastic polyp based on histopathology reports. Multiple logistic regression was done to analyze the association between DD and colonic lesions.
  
  
  RESULTS
  Of the 1986 study subjects, 1,119 (56%) were females, 35% had DD and 56% had at least one polyp. There was a higher prevalence of polyps (70 vs. 49%; OR = 2.3; 95% CI: 1.9-2.8) and adenoma (43 vs. 25%; OR = 2.0; 95% CI: 1.7-2.5) in the diverticular vs. non-diverticula patients. Among patients who underwent screening colonoscopy, the presence of diverticulosis was associated with increased odds of associated polyps (OR = 9.9; 95% CI: 5.4-16.8) and adenoma (OR = 5.1; 95% CI: 3.4-7.8).
  
  
  CONCLUSIONS
  Patients with DD are more likely to harbor colorectal lesions. These findings call for more vigilance on the part of endoscopists during colonoscopy in patients known to harbor colonic diverticula.
authors.affiliation: Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, D.C., USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Ashktorab
authors.forename: Heena
authors.initials: H
authors.lastname: Panchal
authors.forename: Babak
authors.initials: B
authors.lastname: Shokrani
authors.forename: Mansour
authors.initials: M
authors.lastname: Paydar
authors.forename: Andrew
authors.initials: A
authors.lastname: Sanderson
authors.forename: Edward L
authors.initials: EL
authors.lastname: Lee
authors.forename: Rehana
authors.initials: R
authors.lastname: Begum
authors.forename: Tahmineh
authors.initials: T
authors.lastname: Haidary
authors.forename: Adeyinka O
authors.initials: AO
authors.lastname: Laiyemo
authors.forename: Shelly
authors.initials: S
authors.lastname: McDonald-Pinkett
authors.forename: Hassan
authors.initials: H
authors.lastname: Brim
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nouraie
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000473:pathology; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D003111:Colonic Polyps / Q000453:epidemiology* / Q000473:pathology; D003113:Colonoscopy; D003430:Cross-Sectional Studies; D043963:Diverticulosis, Colonic / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D015999:Multivariate Analysis; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000473:pathology; D015995:Prevalence; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology; D014504:Urban Health / Q000706:statistics & numerical data*