title: Differences in Eccentricity Index and Systolic-Diastolic Ratio in Extremely Low-Birth-Weight Infants with Bronchopulmonary Dysplasia at Risk of Pulmonary Hypertension.
abstract: OBJECTIVE
  To compare the left ventricular eccentricity index (EI) and tricuspid valve systolic-diastolic (SD) ratio in infants at risk of bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH).
  
  
  METHODS
  Review of echocardiograms performed on infants born at ≤ 28 weeks' postmenstrual age, categorized into the following three cohorts: BPD and PH (n = 13); BPD only (n = 16); and controls (n = 59). EI was measured from a parasternal short axis 2D image. The SD ratio was measured from the continuous wave Doppler tracing. Groups were compared using Kruskal-Wallis and Wilcoxon rank sum tests.
  
  
  RESULTS
  EI and SD ratios were successfully measured in all infants. There were no differences between controls and BPD cohort. In contrast, the BPD and PH cohort had increased systolic EI (1.46 vs. 1.00-1.01), diastolic EI (1.47 vs. 1.00), and SD ratio (1.12 vs. 0.97-1.00) compared with controls and BPD only cohort (p ≤ 0.01 for all).
  
  
  CONCLUSIONS
  The EI and SD ratio may be useful as a screening tool for PH in this population.
authors.affiliation: Department of Pediatrics, Duke University Hospital, Durham, North Carolina.
authors.forename: A W
authors.initials: AW
authors.lastname: McCrary
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Duke University Hospital, Durham, North Carolina.
authors.forename: J R
authors.initials: JR
authors.lastname: Malowitz
authors.affiliation: Department of Pediatrics, Duke University Hospital, Durham, North Carolina.
authors.forename: C P
authors.initials: CP
authors.lastname: Hornick
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Duke University Hospital, Durham, North Carolina.
authors.forename: K D
authors.initials: KD
authors.lastname: Hill
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Duke University Hospital, Durham, North Carolina.
authors.forename: C M
authors.initials: CM
authors.lastname: Cotten
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Duke University Hospital, Durham, North Carolina.
authors.forename: G H
authors.initials: GH
authors.lastname: Tatum
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Duke University Hospital, Durham, North Carolina.
authors.forename: P C
authors.initials: PC
authors.lastname: Barker
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology*; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology*; D007223:Infant; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D013599:Systole; D016277:Ventricular Function, Left