title: Mean platelet volume is significantly associated with serum levels of thyroid-stimulating hormone in a cohort of older euthyroid subjects.
abstract: OBJECTIVE
  This retrospective and observational study aimed to establish whether any relationship exists between the values of serum thyroid-stimulating hormone (TSH) and those of the mean platelet volume (MPV) in a large cohort of older euthyroid Italian subjects.
  
  
  METHODS
  The study population was represented by a cohort of 1,050 ostensibly healthy and euthyroid patients aged 50 years and older, who were referred for screening of thyroid disorders over a 1-year period.
  
  
  RESULTS
  A significant association was found between MPV and TSH values in both simple (r = 0.12; p < 0.001) and multivariable regression analysis (beta coefficient, 0.07; p < 0.001) after adjustment for age, sex, free thyroxin values and platelet count. After stratification of the study population according to quartiles of serum TSH levels, a graded increase of MPV values was found from the first to the fourth quartile of TSH (p = 0.013). The odds ratio for an increased MPV value of the fourth versus the first quartile of TSH was 1.54 (95% CI, 1.08-2.20; p = 0.017).
  
  
  CONCLUSIONS
  The results of this investigation demonstrate that a significant, positive and independent association exists between MPV and serum TSH values in a large cohort of older euthyroid Italian subjects.
authors.affiliation: a Laboratory of Clinical Chemistry and Hematology , Academic Hospital of Parma , Parma , Italy .
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.affiliation: b Clinical Chemistry Section, Department of Life and Reproductive Sciences, Academic Hospital of Verona , Verona , Italy , and.
authors.forename: Elisa
authors.initials: E
authors.lastname: Danese
authors.affiliation: b Clinical Chemistry Section, Department of Life and Reproductive Sciences, Academic Hospital of Verona , Verona , Italy , and.
authors.forename: Martina
authors.initials: M
authors.lastname: Montagnana
authors.affiliation: c Department of Clinical and Experimental Medicine , Academic Hospital of Parma , Parma , Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Nouvenne
authors.affiliation: c Department of Clinical and Experimental Medicine , Academic Hospital of Parma , Parma , Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Meschi
authors.affiliation: c Department of Clinical and Experimental Medicine , Academic Hospital of Parma , Parma , Italy.
authors.forename: Loris
authors.initials: L
authors.lastname: Borghi
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin
keywords: Mean platelet volume; platelet; thrombosis; thyroid; thyroid-stimulating hormone