title: Assessing effects of prenatal alcohol exposure using group-wise sparse representation of fMRI data.
abstract: Task-based fMRI activation mapping has been widely used in clinical neuroscience in order to assess different functional activity patterns in conditions such as prenatal alcohol exposure (PAE) affected brains and healthy controls. In this paper, we propose a novel, alternative approach of group-wise sparse representation of the fMRI data of multiple groups of subjects (healthy control, exposed non-dysmorphic PAE and exposed dysmorphic PAE) and assess the systematic functional activity differences among these three populations. Specifically, a common time series signal dictionary is learned from the aggregated fMRI signals of all three groups of subjects, and then the weight coefficient matrices (named statistical coefficient map (SCM)) associated with each common dictionary were statistically assessed for each group separately. Through inter-group comparisons based on the correspondence established by the common dictionary, our experimental results have demonstrated that the group-wise sparse coding strategy and the SCM can effectively reveal a collection of brain networks/regions that were affected by different levels of severity of PAE.
authors.affiliation: School of Automation, Northwestern Polytechnical University, Xi'an, China; Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, GSRC 415, Athens, GA, USA.
authors.forename: Jinglei
authors.initials: J
authors.lastname: Lv
authors.affiliation: Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, GSRC 415, Athens, GA, USA.
authors.forename: Xi
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, GSRC 415, Athens, GA, USA.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, GSRC 415, Athens, GA, USA.
authors.forename: Dajiang
authors.initials: D
authors.lastname: Zhu
authors.affiliation: School of Automation, Northwestern Polytechnical University, Xi'an, China; Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, GSRC 415, Athens, GA, USA.
authors.forename: Shijie
authors.initials: S
authors.lastname: Zhao
authors.affiliation: School of Automation, Northwestern Polytechnical University, Xi'an, China; Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, GSRC 415, Athens, GA, USA.
authors.forename: Tuo
authors.initials: T
authors.lastname: Zhang
authors.affiliation: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors.forename: Xintao
authors.initials: X
authors.lastname: Hu
authors.affiliation: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Han
authors.affiliation: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.affiliation: Biomedical Imaging Technology Center, Emory University, 1760 Haygood Drive, Atlanta, GA, USA.
authors.forename: Zhihao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Psychiatry and Behavioral Sciences, Emory University, 1256 Briarcliff Road, Atlanta, GA, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Coles
authors.affiliation: Biomedical Imaging Technology Center, Emory University, 1760 Haygood Drive, Atlanta, GA, USA.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
authors.affiliation: Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, GSRC 415, Athens, GA, USA.
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
mesh_terms: D001143:Arousal / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011340:Problem Solving / Q000502:physiology*; D012016:Reference Values; D055815:Young Adult
keywords: Group-wise; Prenatal alcohol exposure; Sparse coding; Task fMRI