title: A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium polonicum AP2T1.
abstract: Four quinolinones (1-4; 1 is a new compound) were isolated from the static fermentation culture of a shark gill-derived fungus Penicillium polonicum AP2T1. In addition, five new quinolinone derivatives (5-9) and also 1 were obtained in a trimethylsilyldiazomethane-induced methylation reaction of 4. Their structures were elucidated by spectroscopic analyses. In bioassays, compounds 7 and 5 with lactim structures moderately inhibited the proliferation of human cancer cell line HCT116 (wild-type) with IC50-24 h of 8.4 μg/mL and 30.7 μg/mL, respectively; the other compounds displayed weaker inhibition. The p53 gene may play some role in their action as suggested by their much weakened activity towards p53-knockout HCT116 cell line. Besides, 6 and 8 exhibited moderate or weak toxicity to brine shrimp larvae, and 3, 4, 8 and 9 showed weak inhibition against Staphylococcus aureus. It is the first report on elucidation of new compounds with origin of shark-derived fungi.
authors.affiliation: a College of Food Science and Technology, Guangdong Ocean University , Zhanjiang , P.R. China.|b Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Ocean University , Zhanjiang , P.R. China.|c Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Guangdong Ocean University , Zhanjiang , P.R. China.|d School of Environmental and Chemical Engineering, Dalian Jiaotong University , Dalian , P.R. China.|e School of Life Science and Technology, Dalian University of Technology , Dalian , P.R. China.|f Institute of Organic Chemistry, University of Tübingen , Tübingen , Germany.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: g Marine Science and Technology College, Zhejiang Ocean University , Zhoushan , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Mu
authors.affiliation: h Inter-faculty Institute for Biochemistry, University of Tübingen , Tübingen , Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Essmann
authors.affiliation: a College of Food Science and Technology, Guangdong Ocean University , Zhanjiang , P.R. China.|b Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Ocean University , Zhanjiang , P.R. China.|c Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Guangdong Ocean University , Zhanjiang , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.affiliation: f Institute of Organic Chemistry, University of Tübingen , Tübingen , Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Kramer
authors.affiliation: d School of Environmental and Chemical Engineering, Dalian Jiaotong University , Dalian , P.R. China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Bao
authors.affiliation: f Institute of Organic Chemistry, University of Tübingen , Tübingen , Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Grond
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D005880:Gills / Q000382:microbiology*; D006801:Humans; D010407:Penicillium / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012754:Sharks / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D015363:Quinolones
keywords: 2-quinolinones; Penicillium polonicum; antiproliferative; larvicidal; shark gill