title: Fundamental studies on the feasibility of deep eutectic solvents for the selective partition of glaucarubinone present in the roots of Simarouba glauca.
abstract: Several deep eutectic solvents prepared by the complexation of choline chloride as the hydrogen bond acceptor and hydrogen bond donors such as urea, thiourea, ethylene glycol, and glycerol were employed to partition glaucarubinone, an antimalarial compound present in roots of the plant, Simarouba glauca. Among all the solvents, the deep eutectic solvent consisting of the mixture of choline chloride and urea the most suitable to partition the antimalarial compound from the extract selectively. Analytical tools such as high-performance liquid chromatography and electrospray ionization mass spectrometry were used for characterizations, and glaucarubinone extracted from the roots of the plant by conventional solvent extraction method was used as a reference for comparison. The hydrogen and noncovalent bonds formed between glaucarubinone and the deep eutectic solvents could be responsible for the selective partition of the drug molecule.
authors.affiliation: Process Design and Engineering Cell, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India.
authors.forename: Faisal
authors.initials: F
authors.lastname: Kholiya
authors.affiliation: Marine Biotechnology and Ecology Division, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Bhatt
authors.affiliation: Marine Biotechnology and Ecology Division, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India.
authors.forename: Meena R
authors.initials: MR
authors.lastname: Rathod
authors.affiliation: Process Design and Engineering Cell, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India.|AcSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India.
authors.forename: Ramavatar
authors.initials: R
authors.lastname: Meena
authors.affiliation: Marine Biotechnology and Ecology Division, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India.|AcSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India.
authors.forename: Kamalesh
authors.initials: K
authors.lastname: Prasad
keywords: Antimalarial drugs; Deep eutectic solvents; Glaucarubinone; Selective partition