title: Formulation and Solid State Characterization of Nicotinamide-based Co-crystals of Fenofibrate.
abstract: The present investigation deals with formulation of nicotinamide-based co-crystals of fenofibrate by different methods and solid-state characterization of the prepared co-crystals. Fenofibrate and nicotinamide as a coformer in 1:1 molar ratio were used to formulate molecular complexes by kneading, solution crystallization, antisolvent addition and solvent drop grinding methods. The prepared molecular complexes were characterized by powder X-ray diffractometry, differential scanning calorimetry, Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy and in vitro dissolution study. Considerable improvement in the dissolution rate of fenofibrate from optimized co-crystal formulation was due to an increased solubility that is attributed to the super saturation from the fine co-crystals is faster because of large specific surface area of small particles and prevention of phase transformation to pure fenofibrate. In vitro dissolution study showed that the formation of co-crystals improves the dissolution rate of fenofibrate. Nicotinamide forms the co-crystals with fenofibrate, theoretically and practically.
authors.affiliation: Department of Pharmaceutics, Satara College of Pharmacy, Degaon, Satara-415 004, India.
authors.forename: Sheetal
authors.initials: S
authors.lastname: Shewale
authors.affiliation: Research Group, Department of Pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy, Ghogaon, Karad-415 111, India.
authors.forename: A S
authors.initials: AS
authors.lastname: Shete
authors.affiliation: Research Group, Department of Pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy, Ghogaon, Karad-415 111, India.
authors.forename: R C
authors.initials: RC
authors.lastname: Doijad
authors.affiliation: Research Group, Department of Pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy, Ghogaon, Karad-415 111, India.
authors.forename: S S
authors.initials: SS
authors.lastname: Kadam
authors.affiliation: Research Group, Department of Pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy, Ghogaon, Karad-415 111, India.
authors.forename: V A
authors.initials: VA
authors.lastname: Patil
authors.affiliation: Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara-415 002, India.
authors.forename: A V
authors.initials: AV
authors.lastname: Yadav
keywords: Co-crystal; dissolution; fenofibrate; nicotinamide