title: 7.0 T high-resolution 1H-MR spectroscopy of metabolic changes induced by chronic codeine phosphate in rat hippocampus.
abstract: Codeine phosphate is used widely to treat cough and pain. It is actually a sedative, but is known to cause codeine dependence. The exact mechanisms of codeine dependence are not fully understood, but are generally believed to be related to drug-induced neuroadaptation. Metabolites changes can provide information for pathological processes and mechanisms before the shape change. It is very useful for the diagnosis and treatment of drug addiction. We used H NMR spectroscopy in vivo to measure the concentrations of cerebral metabolites in the hippocampus of rats subjected to repeated codeine treatment. After 2 months of codeine treatment, the concentration of N-acetylaspartate was significantly decreased in hippocampi, as was that of glutamate, choline, and taurine. Our study highlights the potential use of metabolic profiling to enhance our understanding of metabolite alteration associated with codeine dependence.
authors.affiliation: aDepartment of Medical Imaging, The Second Affiliated Hospital bDepartment of Medical Imaging, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guang Dong Province, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cao
authors.forename: Pei-yin
authors.initials: PY
authors.lastname: Lin
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Shen
authors.forename: Ye-yu
authors.initials: YY
authors.lastname: Xiao
authors.forename: Ren-hua
authors.initials: RH
authors.lastname: Wu
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003061:Codeine / Q000008:administration & dosage* / Q000378:metabolism*; D005247:Feeding Behavior / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003061:Codeine