title: Differential changes in platelet reactivity induced by acute physical compared to persistent mental stress.
abstract: Platelets are important in hemostasis, but also contain adhesion molecules, pro-inflammatory and immune-modulatory compounds, as well as most of the serotonin outside the central nervous system. Dysbalance in the serotonin pathways is involved in the pathogenesis of depressive symptoms. Thus, changes in platelet aggregation and content of bioactive compounds are of interest when investigating physiological stress-related mental processes as well as stress-related psychiatric diseases such as depression. In the present study, a characterization of platelet reactivity in acute physical and persistent mental stress was performed (aggregation, serotonin and serotonin 2A-receptor, P-selectin, CD40 ligand, matrix metalloproteinase-2 and -9 (MMP-2 and -9), platelet/endothelial adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), β-thromboglobulin (β-TG) and platelet factor 4 (PF-4). Acute physical stress increased platelet aggregability while leaving platelet content of bioactive compounds unchanged. Persistent mental stress led to changes in platelet content of bioactive compounds and serotonin 2A-receptor only. The values of most bioactive compounds correlated with each other. Acute physical and persistent mental stress influences platelets through distinct pathways, leading to differential changes in aggregability and content of bioactive compounds.
authors.affiliation: Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria. Electronic address: katharina.huefner@tirol-kliniken.at.
authors.forename: Katharina
authors.initials: K
authors.lastname: Hüfner
authors.affiliation: Laboratory of Psychiatry and Exp. Alzheimer's Research, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Pia
authors.initials: P
authors.lastname: Koudouovoh-Tripp
authors.affiliation: Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Christina
authors.initials: C
authors.lastname: Kandler
authors.affiliation: Laboratory of Psychiatry and Exp. Alzheimer's Research, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Tanja
authors.initials: T
authors.lastname: Hochstrasser
authors.affiliation: Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Malik
authors.affiliation: Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Giesinger
authors.affiliation: Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Semenitz
authors.affiliation: Laboratory of Psychiatry and Exp. Alzheimer's Research, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Humpel
authors.affiliation: Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sperner-Unterweger
mesh_terms: D000208:Acute Disease; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000502:physiology*; D002908:Chronic Disease; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000502:physiology; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A
keywords: Acute physical stress; Aggregation; Bioactivity; CD40L; Persistent mental stress; Platelets