title: Circulating adropin levels in patients with endometrium cancer.
abstract: OBJECTIVE
  Adropin is a recently identified protein in liver, brain and many peripheral tissues, which is important in energy homeostasis. The purpose of this study is to determine adropin levels in patients with endometrium cancer (EC).
  
  
  METHODS
  A total of 74 patients (47 EC patients and 27 healthy controls) were included in the study. Fasting venous blood samples were collected from all patients. Serum adropin levels were measured by an enzyme-linked immunosorbent assay (ELISA). The correlations between serum adropin levels and clinicopathologic variables were determined.
  
  
  RESULTS
  In body mass index and age-matched groups of patients, adropin levels were determined lower in patients with EC than control group (p < 0.01). Adropin levels were negatively correlated with age (r = -0.265, p = 0.023), homeostasis model-resistance index (HOMA-IR) (r = -0.294, p = 0.005) and fasting insulin levels (r = -0.292, p = 0.001). It was shown that in receiver operator characteristic (ROC) analysis, at cut-off value ≤ 1.055 (ng/ml), adropin had 92.7% sensitivity, 91.5% specificity and had AUC = 0.948, CI; 0.894-1.000 for diagnosis of EC (p < 0.001).
  
  
  CONCLUSIONS
  Adropin seems to be an important protein in pathogenesis of EC. Clearly, there are largely unknown aspects of adropin in EC pathophysiology and require further multi-centered, molecular and genetic studies including high number of cases.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Adnan Menderes University , Aydin , Turkey .
authors.forename: Sümeyra
authors.initials: S
authors.lastname: Nergiz
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Adnan Menderes University , Aydin , Turkey .
authors.forename: Sunduz Ozlem
authors.initials: SO
authors.lastname: Altinkaya
authors.affiliation: b Department of Biostatistics, Faculty of Medicine , Adnan Menderes University , Aydin , Turkey , and.
authors.forename: İmran
authors.initials: İ
authors.lastname: Kurt Ömürlü
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Adnan Menderes University , Aydin , Turkey .
authors.forename: Hasan
authors.initials: H
authors.lastname: Yuksel
authors.affiliation: c Department of Obstetrics and Gynecology, Faculty of Medicine , Mugla Sitki Kocman University , Mugla , Turkey.
authors.forename: Mert
authors.initials: M
authors.lastname: Küçük
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Adnan Menderes University , Aydin , Turkey .
authors.forename: Selda
authors.initials: S
authors.lastname: Demircan Sezer
mesh_terms: D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; C568440:Enho protein, human; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides
keywords: Adropin; endometrium cancer; obesity