title: Effect of topical latanoprost 0.005% on intraocular pressure and pupil diameter in normal and glaucomatous cats.
abstract: OBJECTIVE
  To determine the effects of latanoprost on intraocular pressure (IOP) and pupil diameter (PD) in cats with inherited primary congenital glaucoma (PCG) and normal cats.
  IOP and PD were measured in both eyes (OU) of 12 adult cats (six normal, six PCG), three times per week for 3 weeks prior to, for 3 weeks during, and for 2 weeks following twice-daily treatment with 0.005% latanoprost to the right eye (OD) and vehicle to the left (control) eye (OS). IOP and PD were measured hourly, for 8 h, 1 day prior to, and on the first and last days of treatment. Aqueous humor flow rate (AHF) was determined at baseline and at the end of the treatment phase in six normal cats.
  
  
  RESULTS
  Mean IOP was significantly lower in treated vs. control eyes of PCG cats, for up to 8 h following a single latanoprost treatment, and a maximal IOP reduction of 63% occurred in treated eyes at 3 h. Latanoprost acutely lowered IOP in cats with PCG, but this effect appeared to diminish over 3 weeks of treatment. AHF was modestly increased in the treated eyes of normal cats after 3 weeks of latanoprost treatment, although IOP was not significantly affected. Latanoprost caused miosis, with rebound mydriasis at 24 h posttreatment, in the treated eyes of all cats.
  
  
  CONCLUSIONS
  Further research is needed to determine the suitability and efficacy of latanoprost treatment for long-term IOP-lowering in cats with PCG or other forms of glaucoma.
authors.affiliation: Department of Ophthalmology & Visual Sciences, University of Wisconsin - Madison, Madison, WI, 53792, USA.|Department of Surgical Sciences, University of Wisconsin - Madison, Madison, WI, 53706, USA.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: McDonald
authors.affiliation: Department of Ophthalmology & Visual Sciences, University of Wisconsin - Madison, Madison, WI, 53792, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Kiland
authors.affiliation: Department of Ophthalmology & Visual Sciences, University of Wisconsin - Madison, Madison, WI, 53792, USA.|McPherson Eye Research Institute, University of Wisconsin - Madison, Madison, WI, 53706, USA.
authors.forename: Paul L
authors.initials: PL
authors.lastname: Kaufman
authors.affiliation: Department of Surgical Sciences, University of Wisconsin - Madison, Madison, WI, 53706, USA.|McPherson Eye Research Institute, University of Wisconsin - Madison, Madison, WI, 53706, USA.
authors.forename: Ellison
authors.initials: E
authors.lastname: Bentley
authors.affiliation: Department of Animal Sciences, Iowa State University, Ames, IA, 50011, USA.
authors.forename: N Matthew
authors.initials: NM
authors.lastname: Ellinwood
authors.affiliation: Department of Ophthalmology & Visual Sciences, University of Wisconsin - Madison, Madison, WI, 53792, USA.|Department of Surgical Sciences, University of Wisconsin - Madison, Madison, WI, 53706, USA.|McPherson Eye Research Institute, University of Wisconsin - Madison, Madison, WI, 53706, USA.
authors.forename: Gillian J
authors.initials: GJ
authors.lastname: McLellan
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D005260:Female; D005901:Glaucoma / Q000151:congenital / Q000188:drug therapy / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D009883:Ophthalmic Solutions / Q000009:adverse effects / Q000627:therapeutic use*; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*
chemical_list: D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost
keywords: aqueous humor flow; cat; glaucoma; intraocular pressure; latanoprost; pupil diameter