title: Laparoscopic Adrenalectomy for Large Adrenocortical Carcinoma.
abstract: BACKGROUND
  Adrenocortical cancer (ACC) is a rare disease that is difficult to treat. Laparoscopic adrenalectomy (LA) is performed, even for large adrenocortical carcinomas. However, the oncological effectiveness of LA remains unclear. This review presents the current knowledge of the feasibility and oncological effectiveness of laparoscopic surgery for ACC, with an analysis of data for outcomes and other parameters.
  
  
  METHODS
  A systematic review of the literature was performed by searching the PubMed and Medline databases for all relevant articles in English, published between January 1992 and August 2014 on LA for adrenocortical carcinoma.
  
  
  CONCLUSIONS
  The search resulted in retrieval of 29 studies, of which 10 addressed the outcome of LA versus open adrenalectomy (OA) and included 844 patients eligible for this review. Among these, 206 patients had undergone LA approaches, and 638 patients had undergone OA. Among the 10 studies that compared the outcomes obtained with LA and OA for ACC, 5 noted no statistically significant difference between the 2 groups in the oncological outcomes of recurrence and disease-free survival, whereas the remaining 5 reported inferior outcomes in the LA group. Using a paired t test for statistical analysis, except for tumor size, we found no significant difference in local recurrence, peritoneal carcinomatosis, positive resection margin, and time to recurrence between the LA and OA groups. The overall mean tumor size in patients undergoing LA and OA was 7.1 and 11.2 cm, respectively (P = .0003), and the mean overall recurrence was 61.5 and 57.9%, respectively. The outcome of LA is believed to depend to a large extent on the size and stage of the lesion (I and II being favorable) and the surgical expertise in the center where the patient undergoes the operation. However, the present review shows no difference in the outcome between the 2 approaches across all stages. A poor outcome is likely to result from inadequate surgery, irrespective of whether the approach is open or laparoscopic.
authors.affiliation: Department of Surgery, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Norman Oneil
authors.initials: NO
authors.lastname: Machado
authors.affiliation: Department of Surgery, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Hani
authors.initials: H
authors.lastname: Al Qadhi
authors.affiliation: Department of Surgery, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Khalifa
authors.initials: K
authors.lastname: Al Wahaibi
authors.affiliation: Department of Family Medicine and Public Health, Muscat, Oman.
authors.forename: Syed G
authors.initials: SG
authors.lastname: Rizvi
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods*; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*
keywords: Adrenocortical carcinoma; Laparoscopic adrenalectomy; Peritoneal carcinomatosis