title: Ionic conductivity of peritoneal dialysate: a new, easy and fast method of assessing peritoneal membrane function in patients undergoing peritoneal dialysis.
abstract: BACKGROUND
  Peritoneal membrane function can be assessed using the peritoneal equilibration test (PET) and similar tests, but these are almost always complicated to use, require a considerable amount of working time and their results cannot always be easily interpreted. Ionic conductivity is a measure of the ability of an electrolyte solution to conduct electricity. We tested the hypothesis that the ionic conductivity of peritoneal dialysate can be used to evaluate peritoneal membrane function in peritoneal dialysis patients.
  
  
  METHODS
  We measured the ionic conductivity and classic biochemical parameters of peritoneal dialysate in 69 patients during a modified PET and compared their ability to evaluate peritoneal membrane function and to diagnose ultrafiltration failure (UFF).
  
  
  RESULTS
  Ionic conductivity was correlated well with classical parameters of peritoneal transport as glucose reabsorption of glucose (D/D0: r(2) = 0.62, P < 0.0001) and creatinine transport (D/PCreat: r(2) = 0.72, P < 0.0001). Twelve patients (17%) experienced UFF and, in them, the ionic conductivity area under the receiver-operating characteristic curve was 0.91 (95% confidence interval: 0.81-0.96) with sensitivity of 1.00 and specificity of 0.84 at a cut-off value of 12.75 mS/cm.
  
  
  CONCLUSIONS
  These findings indicate that the ionic conductivity of peritoneal dialysate can be used as a new screening tool to evaluate peritoneal membrane function.
authors.affiliation: Division of Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: La Milia
authors.affiliation: Division of Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pontoriero
authors.affiliation: Nephrology and Dialysis Unit, Provincial Hospital, Camposampiero (Padova), Italy.
authors.forename: Giovambattista
authors.initials: G
authors.lastname: Virga
authors.affiliation: Division of Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Locatelli
mesh_terms: D000368:Aged; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism*; D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007477:Ions / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000379:methods*; D014462:Ultrafiltration
chemical_list: D015314:Dialysis Solutions; D007477:Ions; D003404:Creatinine; D005947:Glucose
keywords: ionic conductivity; peritoneal equilibration test; peritoneal membrane function; ultrafiltration failure