title: APOE Effects on Default Mode Network in Chinese Cognitive Normal Elderly: Relationship with Clinical Cognitive Performance.
abstract: BACKGROUND
  Functional connectivity in default mode network (DMN) may be changed in Alzheimer's disease (AD) patients and related risk populations, such as amnestic mild cognitive impairment (aMCI) patients and APOE ε4 carriers. Exploring DMN changes and related behavioral performance of APOE ε4 population might provide valuable evidence for better understanding the development of AD.
  
  
  METHODS
  Subjects were enrolled from a population-based cohort established in a multi-center study in China. Forty-nine cognitive normal individuals were enrolled after standardized cognitive evaluations, MRI examination and APOE genotyping. Regions of interest (ROI)-based functional connectivity analyses were performed, and voxel-based analyses were used to validate these findings. The correlation between DMN functional connectivity and behavioral performance was further evaluated between APOE ε4ε3 and ε3ε3 carriers.
  
  
  RESULTS
  Comparing to ε3ε3 carriers, functional connectivity between left parahippocampal gyrus and right superior frontal cortex (LPHC-R.Sup.F), left parahippocampal gyrus and medial prefrontal cortex (ventral) (LPHC-vMPFC) were significantly increased in ε4ε3 carriers, while connectivity between cerebellar tonsils and retrosplenial was decreased. LPHC-R.Sup.F connectivity was positively correlated with the changes of delay recall from baseline to follow-up (r = 0.768, p = 0.009), while LPHC-vMPFC connectivity had a positive correlation with MMSE at baseline (r = 0.356, p = 0.018), and a negative correlation with long-delayed recognition at follow-up (r = -0.677, p = 0.031). Significantly increased functional connectivity in vMPFC was confirmed in voxel-based analyses by taking LPHC as seed region.
  
  
  CONCLUSIONS
  APOE ε4 carriers present both increased and decreased functional connectivity in DMN, which is correlated with clinical cognitive performances. DMN changes might be an early sign for cognitive decline.
authors.affiliation: Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Song
authors.affiliation: Institute of Automation, Chinese Academy of Sciences, Beijing, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Long
authors.affiliation: Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Zuo
authors.affiliation: Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
authors.affiliation: Institute of Automation, Chinese Academy of Sciences, Beijing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, China.
authors.forename: Zhiqun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Jia
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000378:metabolism*; D044466:Asian People; D001931:Brain Mapping; D003071:Cognition; D003710:Demography; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006579:Heterozygote; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology*
chemical_list: D001057:Apolipoproteins E