title: Effects of genetic variants for the swine FABP3, HMGA1, MC4R, IGF2, and FABP4 genes on fatty acid composition.
abstract: This study aimed to verify genetic relationships between fatty acid composition (FAC) and genotypes of several genes (FABP3, HMGA1, MC4R, IGF2, and FABP4) using pig breeds. The effects of genetic variations on FAC of the longissimus muscle were statistically significant with additive and dominance effects. The polymorphisms of FABP3 and IGF2 had the largest effects on stearic (C18:0, P=0.009) and γ-linoleic (C18:3n6, P=0.039) acids, respectively, whereas HMGA1 and FABP4 did not show significances. The analysis revealed that MC4R was significantly associated with palmitoleic acid (C16:ln7) and MUFA. Allele frequencies of the genes examined in this analysis were significantly skewed or fixed in the Korean native pig (KNP), whereas the allele frequencies of the crossbreds tended to fall between those of the purebreds except that HMGA1 and FABP4 had approximately the same allele frequencies with Duroc and KNP, respectively. The polymorphisms found in this study could be used as genetic markers in breeding programs to simultaneously change proportions of fatty acids in muscle tissues.
authors.affiliation: Swine Science Division, National Institute of Animal Science, Cheonan 330-801, Republic of Korea.
authors.forename: Joonki
authors.initials: J
authors.lastname: Hong
authors.affiliation: Swine Science Division, National Institute of Animal Science, Cheonan 330-801, Republic of Korea.
authors.forename: Duwan
authors.initials: D
authors.lastname: Kim
authors.affiliation: Swine Science Division, National Institute of Animal Science, Cheonan 330-801, Republic of Korea.
authors.forename: Kyuho
authors.initials: K
authors.lastname: Cho
authors.affiliation: Swine Science Division, National Institute of Animal Science, Cheonan 330-801, Republic of Korea.
authors.forename: Soojin
authors.initials: S
authors.lastname: Sa
authors.affiliation: Swine Science Division, National Institute of Animal Science, Cheonan 330-801, Republic of Korea.
authors.forename: Sunho
authors.initials: S
authors.lastname: Choi
authors.affiliation: Swine Science Division, National Institute of Animal Science, Cheonan 330-801, Republic of Korea.
authors.forename: Younghwa
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Swine Science Division, National Institute of Animal Science, Cheonan 330-801, Republic of Korea.
authors.forename: Juncheol
authors.initials: J
authors.lastname: Park
authors.affiliation: International Technical Cooperation Center, Rural Development Administration, Suwon 441-707, Republic of Korea.
authors.forename: Gilberto Silber
authors.initials: GS
authors.lastname: Schmidt
authors.affiliation: The Ohio State University, Department of Animal Sciences, Columbus, OH 43210, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Davis
authors.affiliation: Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon 441-701, Republic of Korea. Electronic address: chung133@rda.go.kr.
authors.forename: Hoyoung
authors.initials: H
authors.lastname: Chung
mesh_terms: D000273:Adipose Tissue; D000818:Animals; D001947:Breeding; D050556:Fatty Acid-Binding Proteins / Q000235:genetics; D005227:Fatty Acids / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000032:analysis / Q000378:metabolism; D005787:Gene Frequency; D024003:HMGA Proteins / Q000235:genetics; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D008041:Linoleic Acids / Q000378:metabolism; D008460:Meat / Q000032:analysis*; D009132:Muscles / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics; D013229:Stearic Acids / Q000378:metabolism; D013552:Swine
chemical_list: D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D024003:HMGA Proteins; D008041:Linoleic Acids; D044105:Receptor, Melanocortin, Type 4; D013229:Stearic Acids; C031183:stearic acid; D007335:Insulin-Like Growth Factor II
keywords: Association; Fatty acid composition; SNP; Swine