title: Association of CD24 and the adenomatous polyposis coli gene polymorphisms with oral lichen planus.
abstract: OBJECTIVE
  CD24 and the adenomatous polyposis coli (APC) gene polymorphisms are known to predispose to malignant disease. We aimed to investigate their association with risk and susceptibility of oral lichen planus (OLP) in an Israeli Jewish population.
  
  
  METHODS
  The study included 54 patients, of which 41 were females (75.9%) and 13 males (24.1%); of the 533 controls, 224 were females (42.0%) and 309 males (57.9%). Genotyping was performed. Two APC (I1307 K, E1317 Q) and four CD24 variants--C170 T (rs52812045), TG1527 del (rs3838646), A1626 G (rs1058881), and A1056 G (rs1058818)--were assessed. Frequencies were analyzed using the Chi-square test. Two-sided P < .05 values were considered significant. Odds ratios and 95% confidence intervals were obtained by logistic regression analyses.
  
  
  RESULTS
  CD24 A1056 G carriers have a significantly lower risk of OLP compared with individuals with the wild-type variant (P = .001). A significantly lower risk was found for heterozygote (P = .008) and homozygote carriers (P = .002). Homozygote CD24 A1626 G carriers had a significant higher risk for OLP compared with nonhomozygote carriers (P = .040). CD24 C170 T, TG1527 del, and APC polymorphisms did not show significant associations with OLP risk.
  
  
  CONCLUSIONS
  CD24 A1626 G is more frequent in OLP patients, contributes to disease risk, and could play a role in OLP susceptibility. A significant association between CD24 A1056 G and a lower OLP incidence was found, suggesting that it may confer protection against OLP risk and progression.
authors.affiliation: Unit of Oral Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ilana
authors.initials: I
authors.lastname: Kaplan
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Ilana
authors.initials: I
authors.lastname: Nabiochtchikov
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Ari
authors.initials: A
authors.lastname: Leshno
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Menachem
authors.initials: M
authors.lastname: Moshkowitz
authors.affiliation: Unit of Oral Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Shlomi
authors.affiliation: Unit of Oral Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Shlomi
authors.initials: S
authors.lastname: Kleinman
authors.affiliation: Unit of Oral Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Dagan
authors.affiliation: Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Yaacob
authors.initials: Y
authors.lastname: Meshiach
authors.affiliation: Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Lior
authors.initials: L
authors.lastname: Galazan
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Electronic address: nadira@tlvmc.gov.il.
authors.forename: Nadir
authors.initials: N
authors.lastname: Arber
authors.affiliation: Department of Dentistry, University of Toronto, Toronto, Canada.
authors.forename: Limor
authors.initials: L
authors.lastname: Avivi-Arber
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Sarah
authors.initials: S
authors.lastname: Kraus
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051927:CD24 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007557:Israel; D007585:Jews; D017676:Lichen Planus, Oral / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human