title: Persistent Disparities Among Patients With T-Cell Non-Hodgkin Lymphomas and B-Cell Diffuse Large Cell Lymphomas Over 40 Years: A SEER Database Review.
abstract: BACKGROUND
  As of 2013, more than 550,000 people are living with non-Hodgkin lymphoma (NHL).
  
  
  METHODS
  We undertook a large Surveillance Epidemiology and End Results (SEER) based analysis to describe outcome disparities in different subgroups of aggressive T-cell and B-cell NHL patients, with a focus on various ethnicities.
  
  
  RESULTS
  The final analysis included 7662 patients with T-cell and 84,910 with B-cell NHL. Survival analysis revealed that male sex and increasing age were independent predictors of worse overall survival (OS; P < .001). For aggressive T-cell NHL, there was no significant improvement in median OS between 1973 and 2011 (P = .081), and ethnic minorities (Asians, Hispanics, and African Americans) had significantly worse OS than whites (P < .001). There were similar trends for age, sex, and race for diffuse large B-cell NHL, but a significant improvement in median OS was seen over time (P < .001).
  
  
  CONCLUSIONS
  These results are the first to elicit outcomes in a broad classification of ethnic minorities and underscore the urgency for development of novel therapeutics, especially in T-cell NHL. In addition, in-depth studies of disease biology and health care utilization are required for better triage of health care resources, especially for ethnic minorities.
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Crozier
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
authors.forename: Taimur
authors.initials: T
authors.lastname: Sher
authors.affiliation: Department of Preventive Medicine, Health Sciences Campus, University of Southern California, Los Angeles, CA.
authors.forename: Dongyun
authors.initials: D
authors.lastname: Yang
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
authors.forename: Abhisek
authors.initials: A
authors.lastname: Swaika
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
authors.forename: James
authors.initials: J
authors.lastname: Foran
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
authors.forename: Radhika
authors.initials: R
authors.lastname: Ghosh
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
authors.forename: Han
authors.initials: H
authors.lastname: Tun
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Colon-Otero
authors.affiliation: Division of Hematology, Health Sciences Campus, University of Southern California, Los Angeles, CA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Kelly
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
authors.forename: Asher
authors.initials: A
authors.lastname: Chanan-Khan
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL. Electronic address: Ailawadhi.Sikander@Mayo.edu.
authors.forename: Sikander
authors.initials: S
authors.lastname: Ailawadhi
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000368:Aged; D001213:Asian; D005260:Female; D054625:Healthcare Disparities; D006630:Hispanic or Latino; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000208:ethnology / Q000401:mortality* / Q000628:therapy; D016399:Lymphoma, T-Cell / Q000208:ethnology / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D018426:SEER Program; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D044465:White People; D055815:Young Adult
keywords: Ethnic and racial minorities; NHL; Outcome; Survival; Treatment