title: Endoscopic Resection is Infeasible for Early Gastric Cancers with Undifferentiated Components.
abstract: OBJECTIVE
  Aim of this study is to find subgroup of early gastric cancer with lymph node metastasis for which successive further surgical operation is needed after endoscopic resection.
  
  
  METHODS
  A total of 559 lesions of early gastric cancer, which had undergone curative gastrectomy, were enrolled in this study. We retrospectively investigated 10 clinicopathological factors predictive of lymph node metastasis by univariate and multivariate analysis. We showed the frequency of lymph node metastasis of subgroups in combination of independent factors selected by multivariate analysis.
  
  
  RESULTS
  Lymph node metastases were detected in 57 lesions (10.2%). Univariate analysis revealed that lesion size > 30 mm, undifferentiated components, sm massive invasion, lymphatic invasion and venous invasion were factors significantly correlated with lymph node metastasis. By multivariate analysis, risk factors for lymph node metastasis were lesion size > 30 mm, undifferentiated components, sm massive invasion, and lymphatic invasion, with odds ratios of 2.17, 2.30, 5.88 and 8.24, respectively. In lesions with undifferentiated components, LNM were found in all subgroups.
  
  
  CONCLUSIONS
  When we treat early gastric cancers contained undifferentiated components, even if they are predominantly differentiated-type intramucosal lesions, an additional surgical procedure should be considered or careful follow-up is required.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Hamabe
authors.forename: Jun
authors.initials: J
authors.lastname: Nishikawa
authors.forename: Shu
authors.initials: S
authors.lastname: Kiyotoki
authors.forename: Mari
authors.initials: M
authors.lastname: Saito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okamoto
authors.forename: Hideo
authors.initials: H
authors.lastname: Yanai
authors.forename: Minako
authors.initials: M
authors.lastname: Hirahashi
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Matsusaki
authors.forename: Toyokazu
authors.initials: T
authors.lastname: Kawano
authors.forename: Osamu
authors.initials: O
authors.lastname: Miura
authors.forename: Isao
authors.initials: I
authors.lastname: Sakaida
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery*; D002454:Cell Differentiation; D005240:Feasibility Studies; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods*; D005773:Gastroscopy / Q000009:adverse effects; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016017:Odds Ratio; D018579:Patient Selection; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*; D047368:Tumor Burden