title: Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen.
abstract: OBJECTIVE
  To develop a novel injectable strontium-containing calcium phosphate cement with collagen.
  
  
  METHODS
  A novel calcium phosphate bone cement (CPC) was prepared with the addition of strontium element, collagenl, and modified starch; the injectability, solidification time, microstructure, phase composition, compressive strength, anti-collapsibility and histological properties of material were evaluated.
  
  
  RESULTS
  The results showed that the material could be injected with an excellent performance; the modified starch significantly improved the anti-washout property of cement; with the liquid to solid ratio of 0.3, the largest compressive strength of cement was obtained (48.0 MPa ± 2.3 MPa); histological examination of repair tissue showed that the bone was repaired after 16 weeks; the degradation of cement was consistent with the new bone growth.
  
  
  CONCLUSIONS
  A novel injectable collagen-strontium-containing CPC with excellent compressive strength and suitable setting time was prepared, with addition of modified starch. The CPC showed a good anti-washout property and the degradation time of the cement met with the new bone growing. This material is supposed to be used in orthopedic and maxillofacial surgery for bone defects.
authors.affiliation: Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University, Guangzhou 510220, China.
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Zhou
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Ye
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Liang
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry* / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D019245:Compressive Strength; D006650:Histocompatibility Testing; D007267:Injections; D011817:Rabbits; D013324:Strontium / Q000737:chemistry*
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D003094:Collagen; C020243:calcium phosphate; D013324:Strontium