title: A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi.
abstract: O-Prenyl secondary metabolites (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural products. In the last two decades such compounds have been found to exert promising and effective pharmacological activities, mainly in terms of anti-cancer properties. To date about 350 oxyprenylated secondary metabolites, the most part of which having a phenylpropanoid or a polyketide core, have been extracted from plants mainly belonging to the Rutaceae, Apiaceae, and Fabaceae families, and from fungi and bacteria. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about O-prenyl secondary metabolites exhibiting in vitro and in vivo anti-cancer properties from phytochemical and pharmacological point of views.
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy. s.genovese@unich.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Vito Alessandro
authors.initials: VA
authors.lastname: Taddeo
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D054876:Prenylation
chemical_list: D001688:Biological Products; D047188:Chalcones; D003374:Coumarins; D010936:Plant Extracts; C000608131:xinjiachalcone A; C105832:aurapten