title: Characteristics and Risk Factors of Cancer Associated Venous Thromboembolism.
abstract: BACKGROUND
  The objective of this study was to examine the differences in commonly associated characteristics and risk factors of venous thromboembolism (VTE) between patients with and without cancer in a VTE population.
  
  
  METHODS
  Uniform data were collected for patients with a diagnosis of VTE obtaining care at CDC funded Thrombosis Network Centers. Patient characteristics and risk factors were compared in VTE patients with and without cancer. Logistic regression was used to calculate the unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to assess patient characteristics and thrombotic risk factors more frequently identified among VTE patients with cancer compared to those without cancer.
  
  
  RESULTS
  Between August 2003 and April 2011, 3,115 adult patients with a diagnosis of VTE including 189 (6.1%) patients with active cancer participated in the multi-site thrombosis registry. VTE patients with cancer had a higher prevalence of PE and DVT in unusual sites compared to those without cancer. Thrombophilia was more common among VTE patients without cancer than those with cancer (25.1% vs 10.6%, p<0.001). In adjusted analysis, age group≥45years (OR =5.20, 95% CI, 3.30, 8.18), surgery (OR =1.86, 95% CI, 1.19, 2.91), and hypertension (OR =1.66, 95% CI, 1.15, 2.40) were the VTE risk factors more commonly found among VTE patients with cancer.
  
  
  CONCLUSIONS
  The study identified several thrombotic risk factors more likely to be found with cancer associated VTE, which may help to characterize at risk cancer patients and to develop prevention and management strategies in this population.
authors.affiliation: Division of Hematology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. Electronic address: faizas@rutgers.edu.
authors.forename: Ambarina S
authors.initials: AS
authors.lastname: Faiz
authors.affiliation: Division of Hematology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
authors.forename: Imran
authors.initials: I
authors.lastname: Khan
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Michele G
authors.initials: MG
authors.lastname: Beckman
authors.affiliation: Division of Hematology-Oncology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Bockenstedt
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Heit
authors.affiliation: Division of Pediatrics, Michigan State University, East Lansing, MI, USA.
authors.forename: Roshni
authors.initials: R
authors.lastname: Kulkarni
authors.affiliation: University of Colorado and Children's Hospital, Aurora, CO, USA.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Manco-Johnson
authors.affiliation: University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Stephan
authors.initials: S
authors.lastname: Moll
authors.affiliation: Division of Hematology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Ortel
authors.affiliation: Division of Hematology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
authors.forename: Claire S
authors.initials: CS
authors.lastname: Philipp
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D012042:Registries; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology; D054556:Venous Thromboembolism / Q000453:epidemiology*
keywords: Cancer; Deep Vein Thrombosis; Malignancy; Pulmonary Embolism; Thrombophilia; Venous Thromboembolism