title: Integral membrane proteins and free electron lasers - a compatible couple indeed!
abstract: Several structures of membrane transport proteins in complex with mechanistically-relevant ligands, determined by serial femtosecond crystallography of microcrystals at an X-ray free-electron source source, are presented. These results, including investigation of approaches to data quality assessment and refinement from low-redundancy data, indicate the feasibility of using this approach for ligand screening.
authors.affiliation: Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908-0886, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Wiener
keywords: P-type ATPases; XFEL; ligand screening; serial femtosecond crystallography