title: Accuracy Evaluation of CONTOUR(®)PLUS Compared With Four Blood Glucose Monitoring Systems.
abstract: BACKGROUND
  The aim of this study was to compare the accuracy of 5 blood glucose monitoring systems (BGMSs; CONTOUR(®)PLUS [CP], Accu-Chek(®) Active [ACA], Accu-Chek(®) Performa [ACP], FreeStyle Freedom™ [FF], OneTouch(®) SelectSimple™ [OTSS]).
  
  
  METHODS
  Study staff tested fingerstick samples from 106 subjects aged ≥18 years using the 5 BGMSs. Some samples were modified to achieve blood glucose concentrations throughout the measuring range. The primary endpoint was comparison of the mean absolute relative difference (MARD) from the reference value (Yellow Springs Instruments [YSI]) across the overall tested glucose range. Other endpoints were MARD in the low (≤80 mg/dL [≤4.4 mmol/L]), middle (81-180 mg/dL [4.5-10.0 mmol/L]), and high (>180 mg/dL [>10.0 mmol/L]) glucose ranges, and MARD for unmodified samples in the overall glucose range.
  
  
  RESULTS
  CONTOUR(®)PLUS had a statistically significantly lower MARD than all BGMSs across the overall tested range (27-460 mg/dL [1.5-25.5 mmol/L]) and in the high glucose range. In the low glucose range, CP had a lower MARD than all BGMSs, which was statistically significant except for ACP. For unmodified samples across the overall tested range, CP had a lower MARD than all BGMSs and was statistically significantly lower except for ACA.
  
  
  CONCLUSIONS
  CONTOUR(®)PLUS had the lowest mean difference from the reference values (by MARD) when compared with other BGMSs across multiple glucose ranges with modified and unmodified samples.
  
  
  BACKGROUND
  Bayer HealthCare LLC, Diabetes Care.
  
  
  BACKGROUND
  ClinicalTrials.gov Identifier NCT01714232.
authors.affiliation: Bayer HealthCare LLC, Diabetes Care, Whippany, NJ, USA. nancy.dunne@bayer.com.
authors.forename: Nancy
authors.initials: N
authors.lastname: Dunne
authors.affiliation: Bayer HealthCare LLC, Diabetes Care, Whippany, NJ, USA.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Viggiani
authors.affiliation: Bayer HealthCare LLC, Diabetes Care, Whippany, NJ, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Pardo
authors.affiliation: Bayer HealthCare LLC, Diabetes Care, Whippany, NJ, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Robinson
authors.affiliation: Bayer HealthCare LLC, Diabetes Care, Whippany, NJ, USA.
authors.forename: Joan Lee
authors.initials: JL
authors.lastname: Parkes
keywords: Accuracy; MARD; Self-monitoring of blood glucose