title: Antibodies to m-type phospholipase A2 receptor in children with idiopathic membranous nephropathy.
abstract: Idiopathic membranous nephropathy (IMN), the commonest cause of adult nephrotic syndrome (NS), accounts for only a minority of paediatric NS. Antibodies to m-type phospholipase A2 receptor (PLA2R) are seen in two-thirds of adult IMN cases. PLA2R staining in glomerular deposits is observed in 74% and 45% of adult and paediatric IMN cases, respectively. However, there are no reports of anti-PLA2R in paediatric IMN. We evaluated anti-PLA2R levels and PLA2R in gloemrular deposits in paediatric IMN seen at our center. Five cases were enrolled, all the cases stained for PLA2R in glomeruli and three (60%) had antibodies to PLA2R antigen. There was a parellel reduction in proteinuria and anti-PLA2R titer. The present report suggests that PLA2R has a contributory role in the pathogenesis of paediatric IMN.
authors.affiliation: Department of Nephrology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Department of Nephrology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Raja
authors.initials: R
authors.lastname: Ramachandran
authors.affiliation: Department of Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Ashwani
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Ritambhra
authors.initials: R
authors.lastname: Nada
authors.affiliation: Department of Paediatric Allergy and Immunology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Deepti
authors.initials: D
authors.lastname: Suri
authors.affiliation: Department of Paediatric Allergy and Immunology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Anju
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Nephrology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Harbir Singh
authors.initials: HS
authors.lastname: Kohli
authors.affiliation: Department of Nephrology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Krishan Lal
authors.initials: KL
authors.lastname: Gupta
authors.affiliation: Department of Nephrology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.|George Institute for Global Health, New Delhi, India.
authors.forename: Vivekanand
authors.initials: V
authors.lastname: Jha
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001323:Autoantibodies / Q000032:analysis* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D015433:Glomerulonephritis, Membranous / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology / Q000276:immunology*; D054507:Receptors, Phospholipase A2 / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007166:Immunosuppressive Agents; C516360:PLA2R1 protein, human; D054507:Receptors, Phospholipase A2
keywords: glomerulonephritis; membranous nephropathy; nephrotic syndrome; tacrolimus