title: The Groucho/Transducin-like enhancer of split protein family in animal development.
abstract: Corepressors are proteins that cannot bind DNA directly but repress transcription by interacting with partner proteins. The Groucho/Transducin-Like Enhancer of Split (TLE) are a conserved family of corepressor proteins present in animals ranging from invertebrates such as Drosophila to vertebrates such as mice and humans. Groucho/TLE proteins perform important functions throughout the life span of animals, interacting with several pathways and regulating fundamental processes such as metabolism. However, these proteins have especially crucial functions in animal development, where they are required in multiple tissues in a temporally regulated manner. In this review, we summarize the functions of the Groucho/TLE proteins during animal development, emphasizing on specific tissues where they play essential roles.
authors.affiliation: Regional Centre for Biotechnology, NCR Bio-Science Cluster, Faridabad, Haryana, India.
authors.forename: Megha
authors.initials: M
authors.lastname: Agarwal
authors.affiliation: Regional Centre for Biotechnology, NCR Bio-Science Cluster, Faridabad, Haryana, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Regional Centre for Biotechnology, NCR Bio-Science Cluster, Faridabad, Haryana, India.
authors.forename: Sam J
authors.initials: SJ
authors.lastname: Mathew
mesh_terms: D050156:Adipogenesis; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D056970:Co-Repressor Proteins / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000254:growth & development; D006410:Hematopoiesis; D006801:Humans; D007668:Kidney / Q000254:growth & development; D005810:Multigene Family; D055495:Neurogenesis; D010012:Osteogenesis; D010179:Pancreas / Q000254:growth & development; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D056970:Co-Repressor Proteins; D012097:Repressor Proteins; C499043:TLE1 protein, human; C570667:TLE3 protein, human; C091023:gro protein, Drosophila
keywords: corepressor; development; groucho; homeobox genes; transcription factor; transducin-like enhancer of split (TLE)