title: (-)Epigallocatechin-3-gallate prevents the reserpine-induced impairment of short-term social memory in rats.
abstract: Reserpine has been confirmed to induce cognitive dysfunction and increase brain neural oxidative stress. Green tea catechins, particularly (-)epigallocatechin-3-gallate (EGCG), have strong antioxidative properties and can protect against numerous oxidative damages. In this study, we examined the possible protective effects of EGCG on reserpine-induced impairment of short-term memory in rats. Reserpine (1 mg/kg, intraperitoneal)-induced memory impairment was assessed using the social recognition task method; locomotor activity and the olfactory discrimination ability were not altered as measured by an open-field test and an olfactory discrimination test, respectively. EGCG treatment (100 and 300 mg/kg, intraperitoneal, for 7 days, starting 6 days before the reserpine injection) could improve the worsened social memory of reserpine-treated rats. Also, EGCG treatment reduced reserpine-induced lipid peroxidation and enhanced the antioxidation power in the hippocampi of reserpine-treated rats. These results suggest a protective effect of EGCG in treating reserpine-induced impairment of memory, most probably through its powerful antioxidative activities. Accordingly, EGCG may hold a clinically relevant value in preventing reserpine-induced cognitive dysfunction.
authors.affiliation: aDepartment of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital bDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei cFu Jen Catholic University dDepartment of Anesthesia, En Chu Kon Hospital, New Taipei City eDepartment of Optometry, Yuanpei University, Hsinchu fDepartment of Psychiatry, Yuan-Shan br of Taipei Veteran General Hospital, Yilan, Taiwan, ROC.
authors.forename: Hsiang-Chien
authors.initials: HC
authors.lastname: Tseng
authors.forename: Mao-Hsien
authors.initials: MH
authors.lastname: Wang
authors.forename: Hung-Sheng
authors.initials: HS
authors.lastname: Soung
authors.forename: Yi
authors.initials: Y
authors.lastname: Chang
authors.forename: Kuo-Chi
authors.initials: KC
authors.lastname: Chang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004347:Drug Interactions; D006624:Hippocampus / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000037:antagonists & inhibitors*; D012919:Social Behavior; D012920:Social Behavior Disorders / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000975:Antioxidants; D012110:Reserpine; D002392:Catechin; C045651:epigallocatechin gallate