title: Cellulose crosslinked pH-responsive polyurethanes for drug delivery: α-hydroxy acids as drug release modifiers.
abstract: Cellulose crosslinked waterborne polyurethanes (PUs) based on poly ɛ-caprolactone with lactic acid/glycolic acid/dimethylol-propionic acid as a drug release modifiers cum chain extenders were prepared. PUs were loaded with felodipine and drug release was monitored at different pH values. The structure of the polymers was characterized by FTIR, DSC & TGA and SEM. The encapsulation of dug inside PU matrix and the morphology of polymer after drug release were studied by using SEM. All the PUs were observed to degrade under highly basic conditions. The PUs act as pH sensitive drug carriers with an added advantage of modulated release rate as a function of acid chain extenders. The rate of release of the drug was significantly faster at pH 7.4 as compared to gastric pH 1.2, with same incubation time. The PUs reported in the present study may be suitable for medical applications like vaginal drug delivery and colon specific drug delivery.
authors.affiliation: Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India. Electronic address: archu.hrt@gmail.com.
authors.forename: Archana
authors.initials: A
authors.lastname: Solanki
authors.affiliation: Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India. Electronic address: drsonalit@gmail.com.
authors.forename: Sonal
authors.initials: S
authors.lastname: Thakore
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D015736:Felodipine / Q000008:administration & dosage / Q000737:chemistry; D006880:Hydroxy Acids / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D006880:Hydroxy Acids; D011140:Polyurethanes; D002482:Cellulose; D015736:Felodipine
keywords: Biodegradable; Cellulose; Drug delivery; Polyurethanes; pH sensitive