title: Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil.
abstract: METHODS
  Maternal diabetes can program metabolic and cardiovascular diseases in the offspring. The aim of this work was to address whether an olive oil supplemented diet during pregnancy can prevent lipid metabolic alterations in the heart of the offspring of mild diabetic rats.
  
  
  RESULTS
  Control and diabetic Wistar rats were fed during pregnancy with either a standard diet or a 6% olive oil supplemented diet. The heart of adult offspring from diabetic rats showed increases in lipid concentrations (triglycerides in males and phospholipids, cholesterol, and free fatty acids in females), which were prevented with the maternal diets enriched in olive oil. Maternal olive oil supplementation increased the content of unsaturated fatty acids in the hearts of both female and male offspring from diabetic rats (possibly due to a reduction in lipoperoxidation), increased the expression of Δ6 desaturase in the heart of male offspring from diabetic rats, and increased the expression of peroxisome proliferator activated receptor α in the hearts of both female and male offspring from diabetic rats.
  
  
  CONCLUSIONS
  Relevant alterations in cardiac lipid metabolism were evident in the adult offspring of a mild diabetic rat model, and regulated by maternal diets enriched in olive oil.
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Evangelina
authors.initials: E
authors.lastname: Capobianco
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Magalí
authors.initials: M
authors.lastname: Pelesson
authors.affiliation: UMYMFOR (CONICET-UBA), Department of Organic Chemistry, School of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Valeria
authors.initials: V
authors.lastname: Careaga
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Daiana
authors.initials: D
authors.lastname: Fornes
authors.affiliation: UMYMFOR (CONICET-UBA), Department of Organic Chemistry, School of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Ivana
authors.initials: I
authors.lastname: Canosa
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Romina
authors.initials: R
authors.lastname: Higa
authors.affiliation: UMYMFOR (CONICET-UBA), Department of Organic Chemistry, School of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Marta
authors.initials: M
authors.lastname: Maier
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Alicia
authors.initials: A
authors.lastname: Jawerbaum
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy / Q000378:metabolism; D019587:Dietary Supplements; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006321:Heart / Q000187:drug effects; D050602:Linoleoyl-CoA Desaturase / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D000069463:Olive Oil / Q000494:pharmacology*; D047493:PPAR alpha / Q000378:metabolism; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000178:diet therapy* / Q000378:metabolism; D017208:Rats, Wistar
chemical_list: D005227:Fatty Acids; D000069463:Olive Oil; D047493:PPAR alpha; D009569:Nitric Oxide; D050602:Linoleoyl-CoA Desaturase
keywords: Diabetes in pregnancy; Intrauterine programming; Lipid metabolism; Offspring's heart; Olive oil supplementation