title: Transcatheter Pulmonary Valve Replacement for Right Ventricular Outflow Tract Conduit Dysfunction After the Ross Procedure.
abstract: BACKGROUND
  Right ventricular outflow tract (RVOT) conduit dysfunction is a limitation of the Ross procedure. Transcatheter pulmonary valve replacement (TPVR) could alter the impact of conduit dysfunction and the risk-benefit balance for the Ross procedure.
  
  
  METHODS
  Retrospective review of databases from 3 prospective Melody TPV (Medtronic Inc, Minneapolis, MN) trials.
  
  
  RESULTS
  Among 358 patients who were catheterized with the intent to implant a Melody TPV for RVOT conduit stenosis or regurgitation (PR) as part of 3 prospective multicenter studies, 67 (19%) had a prior Ross procedure. Of these, 56 (84%) received a Melody valve; in 5 of the 11 patients who did not, the implant was aborted due to concern for coronary artery compression, and 1 implanted patient required emergent surgery for left coronary compression. The RVOT gradient decreased from a median 38 mm Hg to 13.5 mm Hg (p < 0.001). There was no or trivial PR in all but 4 patients, in whom it was mild. At a median follow-up of 4.0 years, 1 patient died from sepsis. Twelve patients underwent 14 transcatheter (n = 8) or surgical (n = 6) TPV reinterventions for obstruction with stent fracture (n = 9), endocarditis with conduit obstruction (n = 3), or reoperation (n = 2). Freedom from TPV explant was 89% ± 5% at 4 years. Among patients who did not undergo reintervention for obstruction, there was no change in RVOT gradient over time, and all but 1 patient had mild or less PR at last follow-up.
  
  
  CONCLUSIONS
  The TPVR with the Melody valve provides acceptable early outcomes and durable valve function in the majority of Ross patients. Recurrent RVOT obstruction associated with stent fracture was the main reason for reintervention. Coronary compression is not uncommon in Ross patients and should be assessed prior to TPVR.
authors.affiliation: Division of Cardiology, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: gillespie@email.chop.edu.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Gillespie
authors.affiliation: Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.
authors.forename: Doff B
authors.initials: DB
authors.lastname: McElhinney
authors.affiliation: Division of Pediatric Cardiology, Children's Hospital of Pittsburgh of University of Pittsburg Medical Center, Pittsburgh, Pennsylvania.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Kreutzer
authors.affiliation: Division of Pediatric Cardiology, Yale University, New Haven, Connecticut.
authors.forename: William E
authors.initials: WE
authors.lastname: Hellenbrand
authors.affiliation: Department of Pediatric Cardiology, Rady Children's Hospital, University of California San Diego, San Diego, California.
authors.forename: Howaida
authors.initials: H
authors.lastname: El-Said
authors.affiliation: Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, München, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Ewert
authors.affiliation: Department of Pediatric Cardiology, Miami Children's Hospital, Miami, Florida.
authors.forename: John F
authors.initials: JF
authors.lastname: Rhodes
authors.affiliation: Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Søndergaard
authors.affiliation: Division of Cardiology, Seattle Children's Hospital, Seattle, Washington.
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Jones
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization; D006348:Cardiac Surgical Procedures / Q000379:methods; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D011183:Postoperative Complications / Q000601:surgery*; D011664:Pulmonary Valve / Q000601:surgery*; D012189:Retrospective Studies; D014694:Ventricular Outflow Obstruction / Q000601:surgery*; D055815:Young Adult