title: Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp(2) ) and C(sp) Centers.
abstract: Fluorine chemistry is a field undergoing tremendous expansion. Although much attention has been paid to the introduction of the fluorine atom and the CF3 group, less interest has been devoted to the introduction of functionalized fluorinated building blocks, in sharp contrast with the high versatility of the fluorinated products. In this Minireview, the most relevant methods for the introduction of difluoromethylated building blocks are summarized. Access to difluoromethylated arenes, alkenes, and alkynes is highlighted and special attention is paid to explanation of the reaction mechanism.
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex (France).
authors.forename: Marie-Charlotte
authors.initials: MC
authors.lastname: Belhomme
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex (France).
authors.forename: Tatiana
authors.initials: T
authors.lastname: Besset
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex (France). thomas.poisson@insa-rouen.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Poisson
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex (France). xavier.pannecoucke@insa-rouen.fr.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pannecoucke
keywords: alkenes; arenes; fluorine; reaction mechanisms; synthetic methods