title: SRPX2 promotes cell migration and invasion via FAK dependent pathway in pancreatic cancer.
abstract: Sushi repeat-containing protein, X-linked 2, abbreviated as SRPX2, is a candidate downstream target protein for E2A-HLF and involved in disorders of language cortex and cognition. Recent studies have demonstrated that elevated SRPX2 exhibits crucial roles in gastric cancer, however, underlying clinical significance and biological function of SRPX2 in pancreatic ductal adenocarcinoma (PDAC), remains unclear. Data from Oncomine database showed that higher SRPX2 expression is more commonly observed in PDAC compared with normal pancreatic duct, similar results were also found in 12 matched PDAC tissue samples, 7 PDAC cell lines and a tissue microarray containing 81 PDAC specimens as demonstrated by real-time quantitative PCR and immunohistochemistry, respectively. Besides, higher SRPX2 expression was closely correlated with advanced TNM stage. Silencing of endogenous SRPX2 expression reduced abilities of cell migration and invasion of PDAC cells. Further studies revealed that SRPX2 expression in PDAC tissues significantly correlated with the phosphorylation levels of FAK, indicating that FAK dependent pathway may be account for the effect of SRPX2 on cell migration and invasion in PDAC. Collectively, this study reveals that frequently elevated SRPX2 contributes to cell migration and invasion in PDAC and SRPX2-related pathways might be a potential therapeutic target for PDAC.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of BengBu Medical College Bengbu 233003, Anhui, P. R. China.
authors.forename: Zhenyuan
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Department of Oncology, The First Affiliated Hospital of BengBu Medical College Bengbu 233003, Anhui, P. R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Oncology, The First Affiliated Hospital of BengBu Medical College Bengbu 233003, Anhui, P. R. China.
authors.forename: Minghong
authors.initials: M
authors.lastname: Bi
authors.affiliation: Department of Oncology, The First Affiliated Hospital of BengBu Medical College Bengbu 233003, Anhui, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Oncology, The First Affiliated Hospital of BengBu Medical College Bengbu 233003, Anhui, P. R. China.
authors.forename: Zhengquan
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Oncology, The First Affiliated Hospital of BengBu Medical College Bengbu 233003, Anhui, P. R. China.
authors.forename: Hongya
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Oncology, The First Affiliated Hospital of BengBu Medical College Bengbu 233003, Anhui, P. R. China.
authors.forename: Yimei
authors.initials: Y
authors.lastname: Ou
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D005260:Female; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000473:pathology; D009363:Neoplasm Proteins; D009367:Neoplasm Staging; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D008565:Membrane Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C116881:SRPX2 protein, human; D051416:Focal Adhesion Protein-Tyrosine Kinases
keywords: SRPX2; invasion; migration; pancreatic ductal adenocarcinoma