title: MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia.
abstract: We report an extremely rare case of acute myelomonocytic leukemia (M4) with an MLL-ELL fusion gene lacking the PML-RARα rearrangement that transformed from hypergranular acute promyelocytic leukemia (APL) without showing any karyotypic evolution. The treatment was effective with chemotherapy for M4 and idarubicin plus a cytarabine-based chemotherapy protocol without ATRA.
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, China.
authors.forename: Wang Qiang
authors.initials: WQ
authors.lastname: Hu
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, China.
authors.forename: Xiao Xia
authors.initials: XX
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, China.
authors.forename: Rong Rong
authors.initials: RR
authors.lastname: Yang
authors.affiliation: Department of Haematology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Yu
keywords: Acute myelomonocytic leukemia; MLL-ELL; Transform; acute promyelocytic leukemia