title: Relationship between Diabetic Retinopathy and Subclinical Hypothyroidism: a meta-analysis.
abstract: Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the relationship between DR and SCH. All English reports were used Medline, EMbase, Web of Science, Google scholar, and all Chinese ones used CBMDisc (Chinese Biochemical Literature on Disc) and CNKI (China National Knowledge Infrastructure) database. Meta-analysis was performed using RevMan 5.1 software. We obtained eight observational studies. Random-effects meta-analysis indicated a significant association between DR and SCH (odds ratio = 2.13, 95% confidence interval = 1.41 - 3.23, p < 0.001). Based on currently evidence, SCH is probably a significant risk factor for DR.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
authors.forename: Jingyang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
authors.forename: Song
authors.initials: S
authors.lastname: Yue
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Geng
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
authors.affiliation: 1] Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China [2] Department of Epidemiology. School of Public Health, China Medical University, Shenyang 110001, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: 1] Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China [2] Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D003930:Diabetic Retinopathy / Q000150:complications*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D012307:Risk Factors