title: [Lung function in patients with diabetes mellitus].
abstract: BACKGROUND
  Diabetes mellitus is a disease affecting a lot of organs. One of the little known diabetes complication is impairment of pulmonary function. The aim of this study was to compare pulmonary function in two groups: diabetic individuals and obese non-diabetic individuals and to investigate predictive factors of alteration of diffusing capacity of lung for carbon monoxide (DLCO).
  
  
  METHODS
  We retrospectively included all patients hospitalized in department of endocrinology between 1st July 2013 and 31 December 2013 and who underwent pulmonary function tests. All these medical charts of patients were reviewed and patients were classified in two groups: diabetic and obese non-diabetic individuals.
  
  
  RESULTS
  Overall, 89 patients were included, 62 diabetic patients and 27 obese non-diabetic patients. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), medium expiratory flow, expiratory residual volume, total lung capacity (TLC) and DLCO were significantly lower in patients with diabetes mellitus compared to obese non-diabetic patients. A low DLCO was significantly associated with diabetic neuropathy, macrovascular complication (carotid atheroma), impairment of renal function, and insulin treatment.
  
  
  CONCLUSIONS
  Respiratory function is impaired in diabetes mellitus, with a significant decrease in FVC, FEV1, TLC and DLCO.
authors.affiliation: Service de pneumologie aiguë spécialisée et cancérologie thoracique, centre hospitalier Lyon Sud, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France; Faculté de médecine Lyon Est, université Lyon 1, 69003 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Fontaine-Delaruelle
authors.affiliation: Service de pneumologie aiguë spécialisée et cancérologie thoracique, centre hospitalier Lyon Sud, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France; Faculté de médecine et de maïeutique Lyon Sud-Charles Mérieux, université Lyon 1, Oullins, France.
authors.forename: C
authors.initials: C
authors.lastname: Viart-Ferber
authors.affiliation: Faculté de médecine et de maïeutique Lyon Sud-Charles Mérieux, université Lyon 1, Oullins, France; Service d'endocrinologie-diabète-nutrition, centre hospitalier Lyon Sud, hospices civils de Lyon, Pierre-Bénite, France.
authors.forename: C
authors.initials: C
authors.lastname: Luyton
authors.affiliation: Service de pneumologie aiguë spécialisée et cancérologie thoracique, centre hospitalier Lyon Sud, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France; Faculté de médecine et de maïeutique Lyon Sud-Charles Mérieux, université Lyon 1, Oullins, France. Electronic address: sebastien.couraud@chu-lyon.fr.
authors.forename: S
authors.initials: S
authors.lastname: Couraud
mesh_terms: D000328:Adult; D002248:Carbon Monoxide / Q000378:metabolism; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011653:Pulmonary Diffusing Capacity; D011659:Pulmonary Gas Exchange; D012129:Respiratory Function Tests; D012189:Retrospective Studies
chemical_list: D002248:Carbon Monoxide
keywords: Alveolar diffusion capacity; Capacité de diffusion alvéolaire; Diabetes mellitus; Diabète; Exploration fonctionnelle respiratoire; Fonction respiratoire; Lung function; Pulmonary function test