title: Evaluation of Histological and non-Invasive Methods for the Detection of Liver Fibrosis: The Values of Histological and Digital Morphometric Analysis, Liver Stiffness Measurement and APRI Score.
abstract: Prognosis and treatment of liver diseases mainly depend on the precise evaluation of the fibrosis. Comparisons were made between the results of Metavir fibrosis scores and digital morphometric analyses (DMA), liver stiffness (LS) values and aminotransferase-platelet ratio (APRI) scores, respectively. Liver biopsy specimens stained with Sirius red and analysed by morphometry, LS and APRI measurements were taken from 96 patients with chronic liver diseases (56 cases of viral hepatitis, 22 cases of autoimmune- and 18 of mixed origin). The strongest correlation was observed between Metavir score and DMA (r = 0.75 p < 0.05), followed in decreasing order by LS and Metavir (r = 0.61), LS and DMA (r = 0.47) LS and APRI (r = 0.35) and Metavir and APRI (r = 0.24), respectively. DMA is a helpful additional tool for the histopathological evaluation of fibrosis, even when the sample size is small and especially in case of advanced fibrosis. The non-invasive methods showed good correlation with the histopathological methods; LS proved to be more accurate than APRI. The stronger correlation between LS values and Metavir scores, as well as the results of DMA in case of appropriate sample size were remarkable.
authors.affiliation: Second Department of Pathology, Semmelweis University, Ulloi str 93, 1091, Budapest, Hungary.|Department of Pathology, Military Hospital, Budapest, Hungary.
authors.forename: Tünde
authors.initials: T
authors.lastname: Halász
authors.affiliation: Hepatology Center of Buda, Budapest, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Horváth
authors.affiliation: Second Department of Pathology, Semmelweis University, Ulloi str 93, 1091, Budapest, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Kiss
authors.affiliation: First Department of Medicine, Medical University of Pécs, Pécs, Hungary.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Pár
authors.affiliation: St. Istvan and St. Laszlo Hospital, Budapest, Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Szombati
authors.affiliation: Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
authors.forename: Fanni
authors.initials: F
authors.lastname: Gelley
authors.affiliation: Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Nemes
authors.affiliation: Second Department of Pathology, Semmelweis University, Ulloi str 93, 1091, Budapest, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Kenessey
authors.affiliation: Second Department of Pathology, Semmelweis University, Ulloi str 93, 1091, Budapest, Hungary.
authors.forename: Violetta
authors.initials: V
authors.lastname: Piurkó
authors.affiliation: Second Department of Pathology, Semmelweis University, Ulloi str 93, 1091, Budapest, Hungary. schaff.zsuzsa@med.semmelweis-univ.hu.|MTA-SE Tumor Progression Research Group, Hungarian Academy of Sciences, Budapest, Hungary. schaff.zsuzsa@med.semmelweis-univ.hu.
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Schaff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood*; D001792:Blood Platelets / Q000473:pathology*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001219:Aspartate Aminotransferases
keywords: Digital morphometric analysis; Liver biopsy; Liver fibrosis; Liver stiffness