title: Synthesis and Antimicrobial Activities of 3-Methyl-β-Carboline Derivatives.
abstract: The β-carboline alkaloids possess a diverse range of important biochemical effects and pharmacological properties. Sixteen 3-methyl-β-carboline derivatives were synthesized from indole formaldehyde and nitroethane via the Henry reaction, LAH/THF reduction, the Pictet-Spengler reaction and Pd/C/xylene oxidation, including four 1-substituted and twelve 9-substituted 3-methyl- β-carboline derivatives. The structures of all the derivatives were confirmed by 1H NMR, 13C NMR and ESI-MS. Most of these 3-methyl-β-carboline derivatives showed some antibacterial activity.
authors.forename: Jiwen
authors.initials: J
authors.lastname: Zhang
authors.forename: Longbo
authors.initials: L
authors.lastname: Li
authors.forename: Wenjia
authors.initials: W
authors.lastname: Dan
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Qianliang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Hongjin
authors.initials: H
authors.lastname: Bai
authors.forename: Junru
authors.initials: J
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D002243:Carbolines