title: Genetic and molecular aspects of Helicobacter pylori in gastritis, pre- cancerous conditions and gastric adenocrcinoma.
abstract: Gastric adenocarcinoma is one of the most common malignancies worldwide. Many ethological causes have been introduced among which helicobacter pylori, as a gram-negative bacterium has been considered as an important pathological facilitating factor. This agent is also associated with different digestive diseases, such as gastritis, peptic ulcer, and mucosa-associated lymphoid tissue lymphoma. Recently, scientists have been described some molecular aspects that show the role of some apoptotic genes and proteins; for example: P53, Bcl2, C-Myc and Rb-suppressor systems in the H. pylori pathogenesis. Also the relationship between nitric oxide (NOSi genotype) with H. pylori infection has been shown. The aim of this mini-review is to explain better these genetically aspects of H.pylori pathogenesis.
authors.affiliation: Institute Pasteur of Iran, Amol research center, Amol Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shadifar
authors.affiliation: Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari Iran ; Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Ataee
authors.affiliation: Department of Physiology and pharmacology, Babol University of medical sciences, Babol, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Ataie
authors.affiliation: Mazandaran University of M edical sciences, EDC, Sari, Iran.
authors.forename: Ali Morad
authors.initials: AM
authors.lastname: Heydari Gorgi
authors.affiliation: Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari Iran.
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Nasri Nasrabadi
authors.affiliation: Pharmaceutical Sciences Research Center, Islamic Azad University, Tehran Iran.
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Nouri
keywords: Apoptosis; C-Myc; Gastritis; Helicobacter pylori; P53