title: Breast cancer in very young women (<30 years): Correlation of imaging features with clinicopathological features and immunohistochemical subtypes.
abstract: OBJECTIVE
  Early diagnosis of breast cancer in very young women (<30 years) is challenging and the characteristic imaging findings are not yet fully understood. We evaluated the imaging findings of breast cancer in very young women (<30 years) and to correlate them with clinicopathological features.
  
  
  METHODS
  A total of 50 surgically confirmed breast cancers were included in our retrospective study. The medical records were reviewed and the radiological features were analyzed according to the new 5th edition of the ACR BI-RADS lexicon.
  
  
  RESULTS
  The breast cancers in our study population most commonly presented as a self-detected mass (74%), T2-3 stage (58%), histological grade III (52.3%) and ER-positive (80%) subtype. The most common finding was an irregular (87.5%) hyperdense (66.7%) mass with indistinct margins (50%) on mammography and an irregular (75.6%) indistinct (57.8%) hypoechoic/heterogeneous (77.8%) mass without a posterior acoustic feature (60%) on ultrasonography. MRI revealed an irregular shape (63.3%), irregular margins (43.3%), and heterogeneous enhancement (60%) with washout kinetics (69.4%). Mammographically, microcalcifications were correlated with the HER2-enriched type, and mass-type lesions were correlated with triple-negative cancer (p=0.04). An oval/round mass on ultrasound (p=0.005), rim enhancement (p=0.004) and intralesional T2 high signal intensity (p=0.04) on MRI were associated with the triple-negative type.
  
  
  CONCLUSIONS
  On all imaging modalities, breast cancer in very young women usually presented as an irregular mass, and certain radiological features could be used for predicting the specific tumor type.
authors.affiliation: Department of Radiology 1, St. Vincent's Hospital, College of Medicine, The Catholic Unversity of Korea, Republic of Korea.
authors.forename: Yeong Yi
authors.initials: YY
authors.lastname: An
authors.affiliation: Department of Radiology 2, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors.forename: Sung Hun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Radiology 2, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea. Electronic address: lionmain@catholic.ac.kr.
authors.forename: Bong Joo
authors.initials: BJ
authors.lastname: Kang
authors.affiliation: Department of Radiology3, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Park
authors.affiliation: Department of Radiology 4, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors.forename: Na Young
authors.initials: NY
authors.lastname: Jung
authors.affiliation: Department of Radiology 5, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors.forename: Ji Youn
authors.initials: JY
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D016504:Breast Self-Examination; D002114:Calcinosis / Q000175:diagnosis / Q000000981:diagnostic imaging; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology; D044584:Carcinoma, Ductal / Q000175:diagnosis / Q000473:pathology; D003287:Contrast Media; D003952:Diagnostic Imaging / Q000379:methods*; D055088:Early Detection of Cancer; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008207:Lymphatic Metastasis / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography / Q000379:methods; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012189:Retrospective Studies; D016217:Ultrasonography, Mammary / Q000379:methods; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human
keywords: Breast neoplasm; Magnetic resonance imaging; Mammography; Molecular phenotype; Ultrasound; Young women