title: Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation.
abstract: The enantioselective preparation of pharmacologically interesting chroman-fused spirooxindole derivatives is described based on an organocatalytic multicomponent cascade reaction. The compounds synthesized using this method potently inhibited the proliferation of various cancer cell lines. The most potent compound (7e) induced caspase-independent apoptosis and cell cycle arrest in MCF-7 breast cancer cells by interfering with the p53-MDM2 interaction and downstream pathways.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. hegu@scu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhou
authors.forename: Qinjie
authors.initials: Q
authors.lastname: Wu
authors.forename: Mingrui
authors.initials: M
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Xianghong
authors.initials: X
authors.lastname: He
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Fu
authors.initials: F
authors.lastname: Peng
authors.forename: Gu
authors.initials: G
authors.lastname: He
authors.forename: Bo
authors.initials: B
authors.lastname: Han
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002384:Catalysis; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D002839:Chromans / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D061986:MCF-7 Cells; D008958:Models, Molecular; D011487:Protein Conformation; D051736:Proto-Oncogene Proteins c-mdm2 / Q000737:chemistry / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D002839:Chromans; D007211:Indoles; D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2