title: Dilative Arteriopathy and Leucencephalopathy as Manifestations of a Neurometabolic Disease.
abstract: BACKGROUND
  Dilative arteriopathy plus leucencephalopathy as a manifestation of a mitochondrial disorder (MID) is rare.
  
  
  METHODS
  In a 70yo Caucasian female, height 160cm, weight 62kg, with mild right-sided hemiparesis due to subacute ischemic stroke in the posterior leg of the left internal capsule, a megadolichobasilar artery and marked leucencephalopathy and gliosis of the pons were detected. In addition, microbleeds in a peripheral distribution at the cortical/subcortical border were noted. After the exclusion of various differentials, which could have explained her abnormalities, a MID was suspected.
  
  
  CONCLUSIONS
  Dilative arteriopathy of the intra-cerebral arteries, in association with recurrent stroke and supra- and infratentorial leucencephalopathy, but the absence of neurofibromatosis or increased low-density lipoprotein values, is most likely attributable to a non-syndromic MID.
authors.affiliation: Krankenanstalt Rudolfstiftung.
authors.forename: Josef
authors.initials: J
authors.lastname: Finsterer
authors.affiliation: Radiological Department, Krankenanstalt Rudolfstiftung, Vienna, Austria.
authors.forename: Adam
authors.initials: A
authors.lastname: Bastovansky
keywords: Mitochondrial disorder; arteriopathy; dilative arteriopathy; genetics; megadolichobasilar artery; stroke