title: Tubeimoside-1 inhibits the proliferation and activation of mouse T lymphocytes through signal transduction pathways.
abstract: Tubeimoside-1 (TBMS1) is one of the important components in Bolbostemma paniculatum (Maxim.) Franque. In the study, its immunosuppressive effects on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that TBMS1 inhibited ConA-induced T lymphocyte proliferation, decreased the ratio of CD4(+)/CD8(+), suppressed IL-2, IFN-γ, IL-4 and IL-6 production and mRNA expression, down-regulate activation of NF-κB, NFAT2 and AP-1 signal transduction pathways in vitro. In addition, administration of TBMS1 significantly inhibited T cell-mediated DTH response in vivo. These findings indicated that TBMS1 inhibits the proliferation and activation of T lymphocytes in mice.
authors.affiliation: Laboratory of Nutrition and Function Food, College of Light Industry Economics and Management, Jilin University , Changchun, Jilin , People's Republic of China and.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Mengrou
authors.initials: M
authors.lastname: Ren
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.forename: Hongyu
authors.initials: H
authors.lastname: Chen
authors.forename: Xuming
authors.initials: X
authors.lastname: Deng
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D016207:Cytokines / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D012503:Saponins / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects* / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C051084:tubeimoside I
keywords: Cytokine; NF-κB; T lymphocyte; suppression; tubeimoside-1