title: Incidence of renal carcinoma in non-functioning kidney due to renal pelvic stone disease.
abstract: The objective of This study was to report our pathological findings in nephrectomy specimens from patients treated for non-functioning hydronephrotic kidney due to renal pelvic stone disease. A total of 97 patients who underwent nephrectomy for non-functioning hydronephrotic kidneys between January, 2011 and June, 2014 were retrospectively reviewed. A non-functioning kidney was defined as one having paper-thin parenchyma on urinary ultrasound or computed tomography, exhibiting no contrast visualization in the collecting duct system on intravenous urography and having a split renal function of <10% on nuclear renal function studies. Following pathological evaluation, 9 patients were diagnosed with xanthogranulomatous pyelonephritis, 9 with malignant tumors and 79 with chronic pyelonephritis. Of the patients with chronic pyelonephritis, 2 also had renal adenomas. The malignant tumors included 3 transitional cell carcinomas (TCC), 2 squamous cell carcinomas (SCC), 3 renal cell carcinomas (RCC) (1 sarcomatoid, 1 papillary and 1 clear cell RCC), whereas 1 patient had concurrent RCC and TCC. In conclusion, non-functioning kidneys, particularly those with kidney stones, should be managed as possible malignancies, due to the higher incidence of malignant tumors in such patients compared with the normal population.
authors.affiliation: Department of Urology, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Kursad
authors.initials: K
authors.lastname: Zengin
authors.affiliation: Department of Urology, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Tanik
authors.affiliation: Department of Urology, Numune Education and Research Hospital, 01010 Adana, Turkey.
authors.forename: Nevzat Can
authors.initials: NC
authors.lastname: Sener
authors.affiliation: Department of Urology, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Albayrak
authors.affiliation: Department of Urology, Faculty of Medicine, Hitit University, 19100 Corum, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Ekici
authors.affiliation: Department of Urology, Bozyaka Education and Research Hospital, 35140 Izmir, Turkey.
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Bozkurt
authors.affiliation: Department of Urology, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Bakirtas
authors.affiliation: Department of Urology, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Gurdal
authors.affiliation: Department of Urology, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey ; Department of Urology, Diskapi Yildirim Beyazit Education and Research Hospital, 06110 Ankara, Turkey.
authors.forename: Muhammed Abdurrahim
authors.initials: MA
authors.lastname: Imamoglu
keywords: non-functioning kidney; renal carcinoma; renal stone