title: The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging.
abstract: BACKGROUND
  Diffusion-weighted magnetic resonance imaging (DWI) is a widely-accepted diagnostic modality whose efficacy has been investigated by numerous past studies in the differentiation of malignant lesions from benign entities.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the efficiency of diffusion-weighted magnetic resonance imaging in the characterization of renal lesions.
  
  
  METHODS
  Diagnostic accuracy study.
  
  
  METHODS
  A total of 137 patients with renal lesions were included in this study. The median apparent diffusion coefficient (ADC) values as well as the b 800 and b 1600 signal intensities of normal kidneys, solid components of mixed renal masses, and total cystic lesions were evaluated.
  
  
  RESULTS
  There were significant differences between the ADC values of lesions and normal renal parenchyma, and between the ADC values of benign and malignant renal lesions on DWIs at b values of 800 and 1600 s/mm(2) (p<0.001 and p<0.001, respectively). There were significant differences between the ADC values of Bosniak Category 1 and 2 cysts and the ADC values of Bosniak Category 1 and 3 cysts on DWIs at b values of 800 s/mm(2) (p<0.001) and 1600 s/mm(2) (p<0.001). A cutoff value of 1.902 × 10(-3) mm(2)/s for the ADC with a b value of 800 s/mm(2) provided 88% sensitivity and 96% specificity for differentiation between benign and malignant renal lesions. A cutoff value of 1.623 × 10(-3) mm(2)/s for the ADC with a b value of 1600 s/mm(2) provided 79% sensitivity and 96% specificity (p<0.001) for the differentiation between benign and malignant renal lesions.
  
  
  CONCLUSIONS
  Accurate assessment of renal masses is important for determining the necessity for surgical intervention. DWI provides additional value by differentiating benign from malignant renal tumors and can be added to routine kidney MRI protocols.
authors.affiliation: Department of Radiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Cemil
authors.initials: C
authors.lastname: Göya
authors.affiliation: Department of Radiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Cihad
authors.initials: C
authors.lastname: Hamidi
authors.affiliation: Department of Urology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Bozkurt
authors.affiliation: Department of Radiology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey.
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Yavuz
authors.affiliation: Department of Radiology, Bismil State Hospital, Diyarbakır, Turkey.
authors.forename: Suzan
authors.initials: S
authors.lastname: Kuday
authors.affiliation: Department of Radiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Gümüş
authors.affiliation: Department of Pathology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Gül
authors.initials: G
authors.lastname: Türkçü
authors.affiliation: Department of Radiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Hattapoğlu
authors.affiliation: Department of Radiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Aslan
authors.initials: A
authors.lastname: Bilici
keywords: 3 T MRI; Apparent diffusion coefficient; diffusion-weighted magnetic resonance imaging; renal neoplasms