title: Improvement of Physical and Wound Adhesion Properties of Silk Sericin and Polyvinyl Alcohol Dressing Using Glycerin.
abstract: OBJECTIVE
  This study aimed to use glycerin to improve physical and wound adhesion properties of a wound dressing made of silk sericin and polyvinyl alcohol (PVA).
  
  
  METHODS
  Glycerin of a natural-derived plasticizer was used to modify the properties of silk sericin/PVA scaffolds. Various concentrations of glycerin were mixed with silk sericin and PVA and then fabricated into the scaffolds by a freeze-drying technique. The control study was performed to examine the properties of the silk sericin/PVA scaffolds with and without glycerin.
  
  
  METHODS
  Physical, mechanical, wound adhesion properties, the release profile of silk sericin, and in vivo safety of the silk sericin/PVA scaffolds with and without glycerin were investigated.
  
  
  RESULTS
  The silk sericin/PVA scaffolds with glycerin exhibited more homogenous structure, less compressive modulus, higher Young modulus and elongation percentage, and a higher degree of crosslinking compared with the scaffold without glycerin. The silk sericin/PVA scaffold with 2% wt/vol glycerin showed more controlled release of silk sericin than the other scaffolds. The sustained release of silk sericin from the scaffold with glycerin would be advantageous for long-term healing of wounds. The silk sericin/PVA scaffold with 2% (wt/vol) glycerin was less adhesive to the wound compared with the scaffold without glycerin. Furthermore, the implantation of silk sericin/PVA scaffolds with 2% (wt/vol) glycerin did not cause any irritation to the tissue.
  
  
  CONCLUSIONS
  The silk sericin/PVA scaffolds with glycerin were introduced as a biocompatible, more flexible, and less adhesive wound dressing than the scaffold without glycerin.
authors.affiliation: Pornanong Aramwit, PharmD, PhD, is Associate Professor, Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phatumwan, Bangkok, Thailand. Juthamas Ratanavaraporn, PhD, is a Lecturer, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Phatumwan, Bangkok, Thailand. Tippawan Siritientong, PhD, is a Lecturer, Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phatumwan, Bangkok, Thailand.
authors.forename: Pornanong
authors.initials: P
authors.lastname: Aramwit
authors.forename: Juthamas
authors.initials: J
authors.lastname: Ratanavaraporn
authors.forename: Tippawan
authors.initials: T
authors.lastname: Siritientong
mesh_terms: D000818:Animals; D001458:Bandages; D005990:Glycerol; D008297:Male; D011142:Polyvinyl Alcohol; D051381:Rats; D017208:Rats, Wistar; D047030:Sericins; D012883:Skin Ulcer / Q000473:pathology / Q000628:therapy*; D000267:Tissue Adhesions / Q000517:prevention & control*; D054457:Tissue Scaffolds; D014945:Wound Healing
chemical_list: D047030:Sericins; D011142:Polyvinyl Alcohol; D005990:Glycerol