title: Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects.
abstract: OBJECTIVE
  The concept now emerging is that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The present study aimed to investigate the potential associations between thyroid parameters and hyperhomocysteinaemia in a cohort of euthyroid diabetic subjects.
  
  
  METHODS
  Two hundred and seventy-three euthyroid diabetic subjects (167 males and 106 females) were consecutively recruited in this cross-sectional study. Clinical and biomedical data was collected.
  
  
  RESULTS
  TSH level was higher in females than males. Compared to normal-homocysteine group, hyperhomocysteinaemia group was more likely to be elderly, males, with longer diabetes history, and with lower diastolic blood pressure. Free thyroxine (FT4) level was lower in hyperhomocysteinaemia group than in normal-homocysteine group; however, it was not statistically significant. Adjusted for age, sex, body mass index, duration of diabetes, blood pressure, fasting glucose, total cholesterol, and triglyceride in logistic regression analyses, hyperhomocysteinaemia was significantly correlated with FT4 (P = 0.021). No significant association was found with TSH or free triiodothyronine. When analyzed in subjects with TSH < 2.5 uIU/mL separately, we got similar results.
  
  
  CONCLUSIONS
  In conclusion, we identified a relation between hyperhomocysteinemia and FT4 in a group of euthyroid diabetic patients.
authors.affiliation: Department of Endocrinology, Henan Province People's Hospital and Zhengzhou University People's Hospital, 7 Weiwu Road, Zhengzhou, Henan 470003, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Henan Province People's Hospital and Zhengzhou University People's Hospital, 7 Weiwu Road, Zhengzhou, Henan 470003, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Henan Province People's Hospital and Zhengzhou University People's Hospital, 7 Weiwu Road, Zhengzhou, Henan 470003, China.
authors.forename: Quanzhong
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Henan Province People's Hospital and Zhengzhou University People's Hospital, 7 Weiwu Road, Zhengzhou, Henan 470003, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000097:blood*; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine