title: A ratiometric fluorescent probe for rapid, sensitive and selective detection of sulfur dioxide with large Stokes shifts by single wavelength excitation.
abstract: 4-(Benzothiazol-2-yl)-3-hydroxybenzaldehyde, probe 1, has been developed as a ratiometric fluorescent probe for the sensitive and selective detection of sulfur dioxide with a fast response time (within seconds). This probe itself exhibited a yellow emission (λmaxem = 563 nm) with a 186 nm Stokes shift. Upon treatment with sulfite anions, this probe instantaneously displayed a blue emission (λmaxem = 467 nm) with a 133 nm Stokes shift. The large Stokes shifts and absorption spectral overlap of probe 1 both in the absence and in the presence of SO3(2-)/HSO3(-) allow the fluorescence detection under single wavelength excitation. Importantly, this ratiometric probe was successfully demonstrated for the imaging of intracellular sulfite anions in living cells.
authors.affiliation: College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan Province, P. R. China410083. song@rowland.harvard.edu.
authors.forename: Xingjiang
authors.initials: X
authors.lastname: Liu
authors.forename: Qinwei
authors.initials: Q
authors.lastname: Yang
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Chen
authors.forename: Lingna
authors.initials: L
authors.lastname: Mo
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.forename: Jiang
authors.initials: J
authors.lastname: Kang
authors.forename: Xiangzhi
authors.initials: X
authors.lastname: Song
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry*; D002478:Cells, Cultured; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013447:Sulfites / Q000032:analysis*; D013458:Sulfur Dioxide / Q000032:analysis*
chemical_list: C000604286:4-(benzothiazol-2-yl)-3-hydroxybenzaldehyde; D001547:Benzaldehydes; D005456:Fluorescent Dyes; D013447:Sulfites; D013458:Sulfur Dioxide