title: The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.
abstract: This study assessed the effects of citicoline, a nutraceutical, on attention, psychomotor function, and impulsivity in healthy adolescent males.
  
  
  
  Seventy-five healthy adolescent males were randomly assigned to either the citicoline group ( n = 51 with 250 or 500 mg citicoline) or placebo ( n = 24). Participants completed the Ruff 2&7 Selective Attention Test, Finger Tap Test, and the Computerized Performance Test, Second Edition (CPT-II) at baseline and after 28 days of supplementation.
  
  
  
  Individuals receiving citicoline exhibited improved attention ( p = 0.02) and increased psychomotor speed ( p = 0.03) compared with those receiving placebo. Higher weight-adjusted dose significantly predicted increased accuracy on an attention task ( p = 0.01), improved signal detectability on a computerized attention task ( p = 0.03), and decreased impulsivity ( p = 0.01).
  
  
  
  Adolescent males receiving 28 days of Cognizin® citicoline showed improved attention and psychomotor speed and reduced impulsivity compared to adolescent males who received placebo.
authors.affiliation: 1 University of Utah, Salt Lake City, UT, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: McGlade
authors.affiliation: 1 University of Utah, Salt Lake City, UT, USA.
authors.forename: Anna Monica
authors.initials: AM
authors.lastname: Agoston
authors.affiliation: 1 University of Utah, Salt Lake City, UT, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: DiMuzio
authors.affiliation: 2 KYOWA HAKKO BIO CO., LTD, Tsukuba, Ibaraki, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Kizaki
authors.affiliation: 2 KYOWA HAKKO BIO CO., LTD, Tsukuba, Ibaraki, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Nakazaki
authors.affiliation: 3 KYOWA HAKKO U.S.A., INC., New York, NY, USA.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kamiya
authors.affiliation: 1 University of Utah, Salt Lake City, UT, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Yurgelun-Todd
mesh_terms: D000293:Adolescent; D001288:Attention / Q000187:drug effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007175:Impulsive Behavior / Q000187:drug effects*; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects*
chemical_list: D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline
keywords: adolescents; citicoline; cognition; cognitive enhancement