title: Is osteoarthritis a metabolic disorder?
abstract: BACKGROUND
  Obesity is associated with an increased risk of developing osteoarthritis (OA), even in non-weight bearing joints. High levels of adipose tissue-associated inflammation may explain this association.
  Published evidence looking at the associations between components of Metabolic Syndrome (MetS) and knee, hip or hand OA and the higher mortality described with knee OA.
  Development of MetS and OA shares a relationship with adipose tissue-associated inflammation. This review supports this inflammatory pathway being part of the shared mechanism behind obesity as a risk factor for OA and the recently described OA-associated increased mortality.
  In an era of an obesity epidemic, this review identifies a need for well-designed cohort studies assessing early metabolic changes in populations at high risk of OA and MetS, and to identify risk factors for increased mortality in patients with OA.
authors.affiliation: ARUK Sports, Exercise and Osteoarthritis Centre, University of Oxford, Oxford, UK Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Kluzek
authors.affiliation: ARUK Sports, Exercise and Osteoarthritis Centre, University of Oxford, Oxford, UK Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK The Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford OX3 7LD, UK julia.newton@ouh.nhs.uk.
authors.forename: J L
authors.initials: JL
authors.lastname: Newton
authors.affiliation: ARUK Sports, Exercise and Osteoarthritis Centre, University of Oxford, Oxford, UK Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
authors.forename: N K
authors.initials: NK
authors.lastname: Arden
mesh_terms: D054392:Adipokines / Q000502:physiology; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D010003:Osteoarthritis / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors
chemical_list: D054392:Adipokines
keywords: adipokines; metabolic syndrome; osteoarthritis