title: Local Integration Accounts for Weak Selectivity of Mouse Neocortical Parvalbumin Interneurons.
abstract: Dissecting the functional roles of excitatory and inhibitory neurons in cortical circuits is a fundamental goal in neuroscience. Of particular interest are their roles in emergent cortical computations such as binocular integration in primary visual cortex (V1). We measured the binocular response selectivity of genetically defined subpopulations of excitatory and inhibitory neurons. Parvalbumin (PV+) interneurons received strong inputs from both eyes but lacked selectivity for binocular disparity. Because broad selectivity could result from heterogeneous synaptic input from neighboring neurons, we examined how individual PV+ interneuron selectivity compared to that of the local neuronal network, which is primarily composed of excitatory neurons. PV+ neurons showed functional similarity to neighboring neuronal populations over spatial distances resembling measurements of synaptic connectivity. On the other hand, excitatory neurons expressing CaMKIIα displayed no such functional similarity with the neighboring population. Our findings suggest that broad selectivity of PV+ interneurons results from nonspecific integration within local networks. VIDEO ABSTRACT.
authors.affiliation: Center for Perceptual Systems, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department for Functional Architecture and Development of Cerebral Cortex, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458 USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Scholl
authors.affiliation: Center for Perceptual Systems, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.
authors.forename: Jagruti J
authors.initials: JJ
authors.lastname: Pattadkal
authors.affiliation: Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Center for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Dilly
authors.affiliation: Center for Perceptual Systems, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Center for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA. Electronic address: nico@austin.utexas.edu.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Priebe
authors.affiliation: Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Center for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Institute of Cell and Molecular Biology, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.
authors.forename: Boris V
authors.initials: BV
authors.lastname: Zemelman
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D007395:Interneurons / Q000502:physiology*; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008959:Models, Neurological; D019579:Neocortex / Q000166:cytology*; D009415:Nerve Net / Q000502:physiology*; D062308:Optogenetics; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism*; D018408:Patch-Clamp Techniques; D010775:Photic Stimulation; D025341:Principal Component Analysis
chemical_list: D008164:Luminescent Proteins; D010320:Parvalbumins