title: B cells in the aging immune system: time to consider B-1 cells.
abstract: The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has been understudied in terms of immune senescence. Here, we review what is currently known about B cells during aging and go on to describe why B-1 cell biology is an important component of the aging immune system in the context of diseases that most affect the aged population.
authors.affiliation: Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York.
authors.forename: Nichol E
authors.initials: NE
authors.lastname: Holodick
authors.affiliation: Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York.|Departments of Medicine and Molecular Medicine, The Hofstra North Shore-LIJ School of Medicine, Manhasset, New York.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Rothstein
mesh_terms: D000375:Aging / Q000276:immunology* / Q000378:metabolism*; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate / Q000502:physiology*; D007075:Immunoglobulin M / Q000276:immunology / Q000378:metabolism
chemical_list: D007075:Immunoglobulin M; C033027:secretory IgM
keywords: B cells; B-1 cells; aging; senescence