title: Matrix metalloproteinase 9 level as an indicator for restenosis following cervical and intracranial angioplasty and stenting.
abstract: Cervical and intracranial angioplasty and stenting is an effective and safe method of reducing the risk of ischemic stroke, but it may be affected by in-stent restenosis. The present study investigated serum level of matrix metalloproteinase 9 as a predictor of restenosis after 40 patients underwent cervical and/or intracranial angioplasty and stenting. Results showed that restenosis occurred in 30% (3/10) of patients when the serum level of matrix metalloproteinase 9 at 3 days after surgery was 2.5 times higher than preoperative level. No restenosis occurred when the serum level of matrix metalloproteinase 9 at 3 days after surgery was not 2.5 times higher than preoperative level. Restenosis occurred in 12% (2/17) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for more than 30 days after surgery, but only occurred in 4% (1/23) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for less than 30 days after surgery. However, the differences observed were not statistically significant (P > 0.05). Experimental findings indicate that when the serum level of matrix metalloproteinase 9 is 2.5 times higher than preoperative level at 3 days after cervical and intracranial angioplasty and stenting, it may serve as a predictor of in-stent restenosis.
authors.affiliation: Department of Neurology, Fujian Provincial Hospital, Provincial Clinical Department of Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Jun-Peng
authors.initials: JP
authors.lastname: Liu
authors.affiliation: Department of Neurology, Fujian Provincial Hospital, Provincial Clinical Department of Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Yin-Zhou
authors.initials: YZ
authors.lastname: Wang
authors.affiliation: Department of Neurology, Fujian Provincial Hospital, Provincial Clinical Department of Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Yong-Kun
authors.initials: YK
authors.lastname: Li
authors.affiliation: Department of Neurology, Fujian Provincial Hospital, Provincial Clinical Department of Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Fujian Provincial Hospital, Provincial Clinical Department of Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zheng
keywords: cervical and intracranial angioplasty and stenting; intracranial artery stenosis; matrix metalloproteinase 9; nerve regeneration; neural regeneration; restenosis