title: Lead toxicity.
abstract: BACKGROUND
  Since the last In-Depth Review of lead toxicity in 2004 there have been further developments with regard to safe exposure levels for lead workers.
  
  
  OBJECTIVE
  To advise occupational health professionals of the latest research on the multi-system toxic effects of lead and the implications of this research for setting new safe and appropriate occupational suspension limits.
  
  
  METHODS
  An extensive review of the current literature and an investigation of the database used by lead users to produce their submission under the REACH Regulations.
  
  
  RESULTS
  Much of the published research on lead toxicity is on the effects of lead on the general population where blood lead levels are considerably lower than those seen in lead-exposed workers. It is always difficult to compare such studies with those undertaken on exposed workers as they may not be directly comparable and may not have taken into account all confounding variables and the well-acknowledged 'healthy worker' concept. However, it is clear that there is substantial evidence that potential health effects on lead workers may be seen at levels which were previously accepted as 'safe'.
  
  
  CONCLUSIONS
  There is undoubtedly a narrow margin of safety between current occupational blood lead suspension limits and subclinical effect. As a result, the lead users have produced a voluntary Code of Practice with suspension limits significantly below those seen in some national legislation, particularly the Control of Lead at Work Act 2002.
authors.affiliation: RPS Health in Business Ltd, Innospec Manufacturing Park, Oil Sites Road, Ellesmere Port, Cheshire CH65 4EY, UK. david.gidlow@rpsgroup.com.
authors.forename: D A
authors.initials: DA
authors.lastname: Gidlow
mesh_terms: D006801:Humans; D007854:Lead / Q000633:toxicity*; D007855:Lead Poisoning / Q000517:prevention & control*; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health
chemical_list: D007854:Lead
keywords: Inorganic lead; legislation; organic lead; toxicity.