title: Regulation of non-relevant metabolites of plant protection products in drinking and groundwater in the EU: Current status and way forward.
abstract: Non-relevant metabolites are defined in the EU regulation for plant protection product authorization and a detailed definition of non-relevant metabolites is given in an EU Commission DG Sanco (now DG SANTE - Health and Food Safety) guidance document. However, in water legislation at EU and member state level non-relevant metabolites of pesticides are either not specifically regulated or diverse threshold values are applied. Based on their inherent properties, non-relevant metabolites should be regulated based on substance-specific and toxicity-based limit values in drinking and groundwater like other anthropogenic chemicals. Yet, if a general limit value for non-relevant metabolites in drinking and groundwater is favored, an application of a Threshold of Toxicological Concern (TTC) concept for Cramer class III compounds leads to a threshold value of 4.5 μg L(-1). This general value is exemplarily shown to be protective for non-relevant metabolites, based on individual drinking water limit values derived for a set of 56 non-relevant metabolites. A consistent definition of non-relevant metabolites of plant protection products, as well as their uniform regulation in drinking and groundwater in the EU, is important to achieve legal clarity for all stakeholders and to establish planning security for development of plant protection products for the European market.
authors.affiliation: BASF SE, APD/S, 67117 Limburgerhof, Germany. Electronic address: volker.laabs@basf.com.
authors.forename: V
authors.initials: V
authors.lastname: Laabs
authors.affiliation: Bayer CropScience, Alfred Nobel Str. 50, 40789 Monheim am Rhein, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Leake
authors.affiliation: Syngenta, Jealott's Hill, Bracknell, Berkshire RG42 6EY, United Kingdom.
authors.forename: P
authors.initials: P
authors.lastname: Botham
authors.affiliation: BASF SE, GUP/PP, Z470, 67056 Ludwigshafen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Melching-Kollmuß
mesh_terms: D004784:Environmental Monitoring / Q000379:methods; D005060:Europe; D060587:Groundwater / Q000737:chemistry*; D010575:Pesticides / Q000009:adverse effects / Q000737:chemistry; D018570:Risk Assessment; D014874:Water Pollutants, Chemical / Q000737:chemistry*; D018508:Water Purification / Q000379:methods; D014881:Water Supply / Q000379:methods
chemical_list: D010575:Pesticides; D014874:Water Pollutants, Chemical
keywords: Drinking water; Groundwater; Non-relevant metabolite; Pesticide; Regulation; TTC; Threshold of toxicological concern