title: Sleep and respiratory sleep disorders in idiopathic pulmonary fibrosis.
abstract: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease (ILD) characterized by inflammation and progressive scarring of the lung parenchyma. IPF profoundly affects the quality of life (QoL) and fatigue is a frequently disabling symptom. The cause of fatigue is not well understood but patients with IPF often report extremely poor sleep quality and sleep-related breathing disorders (SRBD) that correlate with QoL. IPF patients present alterations in sleep architecture, including decreased sleep efficiency, slow wave sleep and rapid eye movement (REM) sleep, and increased sleep fragmentation. Moreover, sleep related hypoventilation during the vulnerable REM sleep period and obstructive sleep apnea-hypopnea syndrome (OSAHS) are frequent, but remain usually underdiagnosed. These SRBD in IPF are associated with alterations of the sleep structure, reduction of QoL and increased risk of mortality. In the absence of an effective therapy for IPF, optimizing the QoL could become the primary therapeutic goal. In this perspective the diagnosis and treatment of SRBD could significantly improve the QoL of IPF patients.
authors.affiliation: Sleep Disorders Center, Dept of Neurosciences, University of Parma, Italy. Electronic address: giulia.milioli@gmail.com.
authors.forename: Giulia
authors.initials: G
authors.lastname: Milioli
authors.affiliation: Pulmonary Operative Unit, Dept of Thoracic Diseases, G.B. Morgagni-L. Pierantoni Hospital, Forlì, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Bosi
authors.affiliation: Pulmonary Operative Unit, Dept of Thoracic Diseases, G.B. Morgagni-L. Pierantoni Hospital, Forlì, Italy.
authors.forename: Venerino
authors.initials: V
authors.lastname: Poletti
authors.affiliation: Pulmonary Operative Unit, Dept of Thoracic Diseases, G.B. Morgagni-L. Pierantoni Hospital, Forlì, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Tomassetti
authors.affiliation: Sleep Disorders Center, Dept of Neurosciences, University of Parma, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Grassi
authors.affiliation: Sleep Disorders Center, Dept of Neurosciences, University of Parma, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Riccardi
authors.affiliation: Sleep Disorders Center, Dept of Neurosciences, University of Parma, Italy.
authors.forename: Mario Giovanni
authors.initials: MG
authors.lastname: Terzano
authors.affiliation: Sleep Disorders Center, Dept of Neurosciences, University of Parma, Italy.
authors.forename: Liborio
authors.initials: L
authors.lastname: Parrino
mesh_terms: D005221:Fatigue / Q000209:etiology; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications*; D011788:Quality of Life; D020181:Sleep Apnea, Obstructive / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*
keywords: Idiopathic pulmonary fibrosis; Sleep; Sleep-related breathing disorders