title: Metal-Free Iodine-Catalyzed Synthesis of Fully Substituted Pyrazoles and Its Sulphenylation.
abstract: A direct and metal-free access toward fully substituted pyrazoles and its sulphenylation has been established through an iodine-mediated three-component [3 + 2] annulation of β-ketonitrile (or pentane-2,4-dione), arylhydrazines, and aryl sulfonyl hydrazides. The reaction allows the formation of one C-S and two C-N bonds by the multiple bond cleavage including sulfur-oxygen, sulfur-nitrogen, and carbon-oxygen bonds. The method features low-cost and readily accessible substrates, bond-forming efficiency, and broad substrate scopes as well as simple one-pot operation, which makes this strategy highly attractive.
authors.affiliation: †Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.affiliation: †Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China.
authors.forename: Jiang-Kai
authors.initials: JK
authors.lastname: Qiu
authors.affiliation: †Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China.
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Zhu
authors.affiliation: †Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Guo
authors.affiliation: ‡School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Hao
authors.affiliation: ‡School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: ‡School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China.
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D008670:Metals; D011720:Pyrazoles; D007455:Iodine