title: Prevalence of celiac disease in patients with severe food allergy.
abstract: The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe food allergy (IgE > 85 kU/l against food proteins and a history of severe allergic reactions) who underwent specific food oral immunotherapy (OIT), together with 128 children with mild allergy who recovered without OIT, and compared the prevalence data with our historical data regarding healthy schoolchildren. Sixteen patients (5%) with severe allergy and one (0.8%) with mild allergy tested positive for both genetic and serological CD markers, while the prevalence among the schoolchildren was 1%. Intestinal biopsies were obtained in 13/16 patients with severe allergy and in the one with mild allergy, confirming the diagnosis of CD. Sufferers from severe food allergy seem to be at a fivefold increased risk of CD. Our findings suggest that routine screening for CD should be recommended in patients with severe food allergy.
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.|University of Trieste, Trieste, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pillon
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ziberna
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Badina
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.|University of Trieste, Trieste, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ventura
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.|University of Trieste, Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Longo
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Quaglia
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.
authors.forename: L
authors.initials: L
authors.lastname: De Leo
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Vatta
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Martelossi
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.|University of Trieste, Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Patano
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.|University of Trieste, Trieste, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Not
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Berti
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000276:immunology; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic; D005260:Female; D005502:Food / Q000009:adverse effects; D005512:Food Hypersensitivity / Q000150:complications* / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D015995:Prevalence
chemical_list: D001323:Autoantibodies; D006683:HLA-DQ Antigens
keywords: celiac disease; gluten-free diet; severe food allergy