title: Identification of potential targets for ovarian cancer treatment by systematic bioinformatics analysis.
abstract: OBJECTIVE
  To provide a systematic overview to understand the mechanism of ovarian cancer.
  
  
  METHODS
  Data of GSE14407 downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified. Gene ontology and pathway enrichment analysis were performed by Database for Annotation, Visualization and Integrated Discovery (DAVID). Furthermore, the authors constructed the protein-protein interaction (PPI) network and co-expression networks by Cytoscape.
  
  
  RESULTS
  A total 1,442 genes were identified to be differentially expressed. Regulatory effects of DEGs mainly focused on cell cycle, transcription regulation, and cellular protein metabolic process. Significant pathways were determined to be p53 signaling pathway, amino sugar, and nucleotide sugar metabolism. The most significant transcription factor was aryl hydrocarbon receptor nuclear translocator (ARNT). Abnormal spindle-like microcephaly-associated protein (ASPM), Aurora kinase (AURKA), Cyclin-A2 (CCNA2), G2/mitotic-specific cyclin-B1, (CCNB1), and Cyclin-dependent kinase 1 (CDK1) were significant nodes in PPI network.
  
  
  CONCLUSIONS
  The significant genes and pathways show potential targets for the treatment of ovarian cancer.
authors.forename: Q
authors.initials: Q
authors.lastname: Ye
authors.forename: L
authors.initials: L
authors.lastname: Lei
authors.forename: A X
authors.initials: AX
authors.lastname: Aili
mesh_terms: D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000235:genetics / Q000378:metabolism; D064096:Aurora Kinase A / Q000235:genetics / Q000378:metabolism; D016203:CDC2 Protein Kinase; D000077216:Carcinoma, Ovarian Epithelial; D019295:Computational Biology; D056751:Cyclin A2 / Q000235:genetics / Q000378:metabolism; D056744:Cyclin B1 / Q000235:genetics / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D015398:Signal Transduction / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: C497396:ARNT protein, human; C467202:ASPM protein, human; C503721:CCNA2 protein, human; C534699:CCNB1 protein, human; D056751:Cyclin A2; D056744:Cyclin B1; D009419:Nerve Tissue Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; C576917:AURKA protein, human; D064096:Aurora Kinase A; D016203:CDC2 Protein Kinase; C528899:CDK1 protein, human; D018844:Cyclin-Dependent Kinases