title: Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels.
abstract: OBJECTIVE
  To determine the relationship between serum P levels on the day of hCG administration and ongoing pregnancy rates.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University-affiliated private IVF.
  
  
  METHODS
  A total of 2,458 couples undergoing IUI.
  
  
  METHODS
  Ovarian stimulation with human recombinant FSH.
  
  
  METHODS
  Ongoing pregnancy and miscarriage rates.
  
  
  RESULTS
  Progesterone concentrations were significantly higher given that the E2 concentration increased. Ongoing pregnancy rates were significantly decreased in women with P levels higher than 1.1 ng/mL; similar results were obtained in relation to miscarriage rates.
  
  
  CONCLUSIONS
  Significant differences in ongoing pregnancy rates when P levels were elevated on the day of hCG administration may help clinicians to counsel patients about the reduced success rates with IUI and manage the timing of insemination to optimize implantation.
authors.affiliation: Department of Reproductive Medicine, Instituto Valenciano de Infertilidad Madrid, Madrid, Spain. Electronic address: antonio.requena@ivi.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Requena
authors.affiliation: Department of Reproductive Medicine, Instituto Valenciano de Infertilidad Madrid, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Department of Reproductive Medicine, Instituto Valenciano de Infertilidad Madrid, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pacheco
authors.affiliation: Department of Reproductive Medicine, Instituto Valenciano de Infertilidad Madrid, Madrid, Spain; Departments of Nursing, Gynecology and Obstetrics, Pediatrics, and Psychiatry, Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: García-Velasco
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000453:epidemiology; D000328:Adult; D005260:Female; D005498:Follicular Phase / Q000097:blood*; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014599:Uterus
chemical_list: D011374:Progesterone
keywords: Progesterone levels; intrauterine insemination; ongoing pregnancy