title: Intracranial meningioma surgery in the elderly (over 65 years): prognostic factors and outcome.
abstract: BACKGROUND
  Meningiomas are more prevalent in elderly individuals; however, the surgical outcome and prognostic factors in this age group are unclear. This retrospective study aimed to identify the prognostic factors of elderly patients with intracranial meningiomas who underwent surgical resection.
  
  
  METHODS
  Eighty-six patients (aged ≥ 65) diagnosed with an intracranial meningioma were surgically treated at our department. The clinical, radiological, and follow-up data were retrospectively reviewed. Univariate and multivariate logistic analyses were performed to identify relationships between factors [age, sex, neurological condition, concomitant disease, American Society of Anesthesiology (ASA) classification, preoperative Karnofsky Performance Scale (KPS) score, tumor location and size, peritumoral edema, and Simpson resection grade] and outcome.
  
  
  RESULTS
  One patient (1.2 %) died within 30 days of surgery. The morbidity rate was 37.2 %. Postoperative morbidities occurred more frequently in the patients with preoperative neurological deficits than in those without (p = 0.049). Univariate analysis identified significant relationships between a low KPS score (≤ 70) at discharge and preoperative neurological deficits, low preoperative KPS score (≤ 70), and critical tumor location (p < 0.001, p < 0.001, and p = 0.04, respectively). In the multivariate logistic analysis, only the preoperative KPS score remained significant for the KPS score at discharge (p = 0.005); there was no significant association with the most recent KPS score.
  
  
  CONCLUSIONS
  The outcome of intracranial meningioma resection in elderly individuals is favorable if the preoperative KPS score is >70 and no neurological deficits are present. Treatment decisions should be patient-specific, and additional factors should be considered when operations are performed in patients with a low preoperative KPS score or neurological deficits.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi, 530021, China.
authors.forename: Zhi-Yi
authors.initials: ZY
authors.lastname: Chen
authors.forename: Chuan-Hua
authors.initials: CH
authors.lastname: Zheng
authors.lastname: Tang Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Su
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Lu
authors.forename: Chao-Yuan
authors.initials: CY
authors.lastname: Zhang
authors.forename: Shao-Wen
authors.initials: SW
authors.lastname: Xiao
authors.forename: Yuan-Fu
authors.initials: YF
authors.lastname: Tan
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000601:surgery*; D008579:Meningioma / Q000601:surgery*; D019635:Neurosurgical Procedures / Q000009:adverse effects* / Q000706:statistics & numerical data; D016019:Survival Analysis