title: The role of miR-21 in proliferation and invasion capacity of human tongue squamous cell carcinoma in vitro.
abstract: Tongue squamous cell carcinoma is one of the most common cancers, which has the highest incidence in oral maxillofacial malignant tumors. MiR-21 may promote tumorigeness by down-regulating tumor suppressing genes and/or controlling the genes for cell differentiation and apoptosis, and it has been identified as the most expressive and unusual in a number of profiling experiments. The study shows there are high expressions of miR-21 in tongue squamous cell carcinoma cell lines (Tca8113 and its high metastatic lines), especially in high metastatic lines. miR-21 silencing could suppress the capacity of proliferation, migration and invasion, arrest the cell cycle and induce apoptosis of tongue squamous cell carcinoma cell lines (Tca8113 and its high metastatic lines). All the results indicate that miR-21 will probably open a new path to the gene therapy for oral squamous cell carcinoma.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University Chengdu 610041, China ; Department of Oral and Maxillofacial Surgery, Tianjin Medical University General Hospital Tianjin 30052, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, China; Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration Tianjin 300060, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Oral and Maxillofacial Surgery, Tianjin Medical University General Hospital Tianjin 30052, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Lv
authors.affiliation: Department of Head and Neck Surgical Oncology, West China School of Stomatology, Sichuan University Chengdu 610041, China.
authors.forename: Longjiang
authors.initials: L
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D059585:G1 Phase Cell Cycle Checkpoints; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D034622:RNA Interference; D015398:Signal Transduction; D000077195:Squamous Cell Carcinoma of Head and Neck; D013997:Time Factors; D014062:Tongue Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014162:Transfection
chemical_list: C524940:MIRN21 microRNA, human; D035683:MicroRNAs
keywords: invasion; miR-21; proliferation; tongue squamous cell carcinoma