title: Fusiform Aneurysms Are Associated with Aortic Root Dilatation in Patients with Subarachnoid Hemorrhage.
abstract: BACKGROUND
  Aortic root dimension (ARD), an echocardiographic marker of aortopathy, has recently been associated with intracranial aneurysm eccentricity, suggesting a common underlying pathophysiology between intracranial aneurysm and aortopathy.
  
  
  OBJECTIVE
  To identify specific intracranial aneurysm-related parameters that independently correlate with ARD in patients with subarachnoid hemorrhage.
  
  
  METHODS
  Clinical and aneurysm-related parameters obtained from 151 patients with ruptured intracranial aneurysms, and who also underwent echocardiography with ARD measured, were examined. Univariate and multivariate analysis were performed to determine correlation of these parameters with ARD.
  
  
  RESULTS
  151 patients who were evaluated from 2008 to 2013 were analyzed. Multivariate linear regression revealed that male gender and fusiform aneurysms were correlated with higher ARD (P < 0.01 and P = 0.041, respectively) after adjustment for other morphological and clinical variables.
  
  
  CONCLUSIONS
  Fusiform aneurysms are correlated with larger ARD than saccular aneurysms, suggesting a shared pathophysiologic mechanism with aortopathy.
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Anil
authors.initials: A
authors.lastname: Can
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Victor
authors.initials: V
authors.lastname: Volovici
authors.affiliation: Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Ruben
authors.initials: R
authors.lastname: Dammers
authors.affiliation: Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Clemens M F
authors.initials: CM
authors.lastname: Dirven
authors.affiliation: Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Calum A
authors.initials: CA
authors.lastname: MacRae
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. Electronic address: rdu@partners.org.
authors.forename: Rose
authors.initials: R
authors.lastname: Du
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000783:Aneurysm / Q000150:complications*; D017542:Aneurysm, Ruptured / Q000150:complications*; D001011:Aorta / Q000473:pathology*; D001021:Aortic Valve; D000082882:Bicuspid Aortic Valve Disease; D004108:Dilatation, Pathologic / Q000209:etiology; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications*; D006349:Heart Valve Diseases / Q000150:complications*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000150:complications*
keywords: Aortic root diameter; Aortopathy; Fusiform; Intracranial aneurysm