title: A rare case of Barrett's adenocarcinoma including squamous cell carcinoma component.
abstract: We present a rare case of Barrett's cancer with a particular histology composed of various differentiated adenocarcinoma (AC) and squamous cell carcinoma (SCC) cells. A 52-year-old man with a long-standing complaint of heartburn visited a medical center for an annual check-up by esophagogastroduodenoscopy (EGD). Although high-grade reflux esophagitis with Barrett's esophagus was identified 3 years earlier, he had not visited a hospital for medication. In 2008, he underwent EGD and a 0-IIa + IIc type of superficial cancerous lesion was found in the long segment of Barrett's esophagus. The histology of this lesion was confirmed as adenosquamous carcinoma by biopsy specimens. Based on the results of computed tomography, endoscopic ultrasonography, and a barium study, the cancer was found to invade the submucosal layer, and the patient underwent surgery. A histological study after the surgery demonstrated various subtypes of AC, such as mucinous, signet-ring cell and tubular AC, with a focal SCC component. Barrett's AC containing SCC is very rare, and its carcinogenesis is of interest.
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mishima
authors.affiliation: Division of Endoscopy, Shimane University Hospital, Izumo, Shimane, 693-8501, Japan. amano@med.shimane-u.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Amano
authors.affiliation: Division of Endoscopy, Shimane University Hospital, Izumo, Shimane, 693-8501, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yuki
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Kusunoki
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Oka
authors.affiliation: Division of Endoscopy, Shimane University Hospital, Izumo, Shimane, 693-8501, Japan.
authors.forename: Goichi
authors.initials: G
authors.lastname: Uno
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ishimura
authors.affiliation: Department of Organ Pathology, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Hamaoka
authors.affiliation: Department of Organ Pathology, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ishikawa
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
keywords: Adenosquamous carcinoma; Barrett’s cancer; Barrett’s esophagus