title: ALTERED BOLD RESPONSE WITHIN THE CORE FACE-PROCESSING NETWORK IN CONGENITAL PROSOPAGNOSIA.
abstract: OBJECTIVE
  Congenital prosopagnosia is a life-long disorder of face perception. To study the neural backgrounds of congenital prosopagnosia we measured the blood oxygen level-dependent response of congenital prosopagnosic participants, using functional magnetic resonance imaging.
  
  
  METHODS
  We tested three persons of the family (father, daughter and son), having symptoms of congenital prosopagnosia, as well as healthy controls, using combined neuropsychological and functional magnetic resonance imaging methods. To reveal the neural correlates of the impairments, blood oxygen level-dependent responses within the occipito-temporal cortex were measured to faces and nonsense object images in a block-design experiment.
  
  
  RESULTS
  Neuropsychological tests demonstrated significant impairments of face perception/recognition in each subject. We found that the activity of the fusiform and occipital face areas as well as of the lateral occipital cortex was significantly reduced in congenital prosopagnosic participants when compared to controls. Analysis of the hemodynamic response function revealed a lower peak response, but also a significantly faster and stronger decay of the blood oxygen level-dependent response in the occipito-temporal areas in congenital prosopagnosic participants when compared to controls.
  
  
  CONCLUSIONS
  Our results emphasize the dysfunction of the core face processing system, as well as the lateral occipital complex, in congenital prosopagnosia. Further, the functional impairment of these areas is signalled best by the altered hemodynamic response function, showing abnormally low initial peak and stronger and faster decay in the later parts of the blood oxygen level-dependent response.
authors.forename: Kornél
authors.initials: K
authors.lastname: Németh
authors.forename: Márta
authors.initials: M
authors.lastname: Zimmer
authors.forename: Krisztina
authors.initials: K
authors.lastname: Nagy
authors.forename: Éva M
authors.initials: ÉM
authors.lastname: Bankó
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Vidnyanszky
authors.forename: Pál
authors.initials: P
authors.lastname: Vakli
authors.forename: Gyula
authors.initials: G
authors.lastname: Kovács
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D005145:Face; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D020238:Prosopagnosia / Q000151:congenital* / Q000503:physiopathology