title: Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation.
abstract: This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, LabEx LERMIT. 91191 Gif-sur-Yvette (France).
authors.forename: Hajer
authors.initials: H
authors.lastname: Abdelkafi
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, LabEx LERMIT. 91191 Gif-sur-Yvette (France).
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Cintrat