title: Effects of interleukin-37 on cardiac function after myocardial infarction in mice.
abstract: BACKGROUND
  Interleukin-37 (IL-37) is a new discovered member of the interleukin family and plays anti-inflammatory effect in some inflammatory disease. A recent study found that IL-37 elevated significantly in peripheral blood of patients with acute myocardial infarction. We aimed to explore the effect IL-37 on cardiac function after mice myocardial infarction (MI) and its mechanism.
  
  
  METHODS
  Acute MI mouse model was established and divided into three groups: sham group, MI group and IL-37 treatment group. MPO expression was detected by immunohistochemistry; NF-κB signaling pathway was tested by Western blot; and cardiac function was measured by echocardiography.
  
  
  RESULTS
  Compared with MI mice, IL-37 treatment showed an obvious decrease of MPO expression, suppression of p-p65 expression, and improved cardiac function by decreasing left ventricular shortening fraction (LVFS).
  
  
  CONCLUSIONS
  IL-37 may improve MI mice cardiac function via inhibition of inflammatory NF-κB signaling pathway.
authors.affiliation: Department of Cardiology, Binzhou People's Hospital Binzhou City 256610, Shandong Province, China.
authors.forename: Daoying
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Critical Care Medicine, Binzhou People's Hospital Binzhou City 256610, Shandong Province, China.
authors.forename: Aiqin
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Binzhou People's Hospital Binzhou City 256610, Shandong Province, China.
authors.forename: Fengqin
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Binzhou People's Hospital Binzhou City 256610, Shandong Province, China.
authors.forename: Junhong
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Cardiology, Binzhou People's Hospital Binzhou City 256610, Shandong Province, China.
authors.forename: Xiuzhou
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D018836:Inflammation Mediators / Q000378:metabolism; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D008810:Mice, Inbred C57BL; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects*; D051996:Transcription Factor RelA / Q000378:metabolism; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D002316:Cardiotonic Agents; D018836:Inflammation Mediators; D007375:Interleukin-1; C498144:Rela protein, mouse; D051996:Transcription Factor RelA; D009195:Peroxidase
keywords: Interleukin-37; cardiac function; inflammation; myocardial infarction