title: Corrective spinal surgery may be protective against stroke in patients with blunt traumatic vertebral artery occlusion.
abstract: OBJECT Approximately 10% of patients with blunt traumatic extracranial cerebrovascular injury have a complete occlusion of the vertebral artery (VA). Ischemic stroke due to embolization of thrombus from an occluded VA following cervical spine surgery has been observed. The risk of ischemic stroke with cervical spine surgery in the presence of an occluded VA, however, has never been determined. METHODS A retrospective chart review of 52 patients with a VA occlusion following a blunt trauma was performed. Clinical and radiographic characteristics were collected and analyzed. RESULTS Ten patients (19.2%) suffered an ischemic stroke attributable to a traumatic VA occlusion. Univariate analysis demonstrated that patients with ischemic stroke were significantly older (p = 0.042) and had a lower rate of cervical spine surgery (p < 0.005). Multivariate analysis found cervical spine surgery to be protective against ischemic stroke (OR 0.049 [95% CI 0.014-0.167], p = 0.014); increasing age and bilateral VA injury (bilateral occlusion or unilateral occlusion with contralateral dissection) were risk factors for ischemic stroke (OR 1.05 [95% CI1.02-1.07], p = 0.065 and OR 13.2 [95% CI 2.98-58.9], p = 0.084, respectively). CONCLUSIONS Traumatic VA occlusion is associated with a risk of ischemic stroke and mortality. Corrective cervical spine surgery potentially decreases the risk of ischemic stroke by stabilizing the spine and thereby reducing motion across the occluded segment of the VA and preventing embolization of thrombus. While a high stoke risk may be inherent to the disease, novel therapies should be investigated.
authors.affiliation: Department of Neurosurgery, University of Alabama at Birmingham, Alabama; and.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Foreman
authors.affiliation: Department of Neurosurgery, University of Alabama at Birmingham, Alabama; and.
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Griessenauer
authors.affiliation: Harvard Medical School, Harvard University, Boston, Massachusetts.
authors.forename: Michelle
authors.initials: M
authors.lastname: Chua
authors.affiliation: Department of Neurosurgery, University of Alabama at Birmingham, Alabama; and.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Hadley
authors.affiliation: Department of Neurosurgery, University of Alabama at Birmingham, Alabama; and.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Harrigan
keywords: CTA = CT angiography; TCVI = traumatic cerebrovascular injury; VA = vertebral artery; dissection; spine fracture; spine surgery; stroke; trauma; vascular disorders; vertebral artery occlusion