title: Benign fibrous histiocytoma arising at the temporal bone of an infant--case report and review of the literature.
abstract: OBJECTIVE
  We report a very rare case of a fast-growing benign fibrous histiocytoma at the temporal bone.
  
  
  METHODS
  A 1-year-old girl was referred for investigation of a right temporal mass that increased during 2-week observation. Imaging studies showed a lytic, loculated skull tumor at the left temporal bone. On magnetic resonance imaging scans, the tumor was isointense on T1- and relatively high-intense on T2-weighted images. The tumor was mostly homogeneously enhanced by gadolinium. On diffusion-weighted images, it was iso- to relatively low-intense; perfusion-weighted images revealed low perfusion.
  
  
  RESULTS
  Complete macroscopic resection of the tumor was performed. Immunohistochemical analysis showed that the tumor was positive for CD68 and α-smooth muscle actin and negative for CD1a and CD34; the MIB-1 labeling index was 4 %. A diagnosis of primary benign fibrous histiocytoma of the skull was made. At 6-month follow-up, there were no clinical or radiological signs of tumor recurrence and/or metastasis.
  
  
  CONCLUSIONS
  We review the clinical, radiological, and immunohistochemical characteristics of benign fibrous histiocytoma at the skull.
authors.affiliation: Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. fyama@hiroshima-u.ac.jp.
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Yamasaki
authors.affiliation: Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takayasu
authors.affiliation: Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Nosaka
authors.affiliation: Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
authors.forename: Amatya Jeet
authors.initials: AJ
authors.lastname: Vishwa
authors.affiliation: Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Takeshima
authors.affiliation: Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Yoshihiro
authors.affiliation: Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kurisu
mesh_terms: D000199:Actins / Q000378:metabolism; D015703:Antigens, CD / Q000378:metabolism; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D007223:Infant; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D013701:Temporal Bone / Q000601:surgery*
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D015703:Antigens, CD; D019394:Ki-67 Antigen
keywords: Benign fibrous histiocytoma; Neurocranium; Skull tumor