title: MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma.
abstract: Matrix metalloproteinase 14 (MMP14) has been shown to play a significant role in several types of cancers, but little is known about the function of MMP14 in nasopharyngeal carcinoma (NPC) carcinogenesis. The aim of this study was to investigate the role of MMP14 in NPC using NPC tumor samples or tissue microarray. We have shown that MMP14 was increased in NPC samples compared with normal nasopharynx (NP) tissues in microarray data (GSE13597). Both MMP14 mRNA and protein expression were markedly higher in NPC tissues than in NP tissues. High levels of MMP14 protein were found positively correlate with the status of late clinical stages of tumor and tumor with lymph node metastasis. Moreover, we have shown that MMP14 expression promoted the cell migration and invasion of NPC cells in vitro and regulated the expression of EMT-associated genes. Our data demonstrated that MMP14 plays an important role in regulation of migration and invasion of NPC cells, and constitutes a potential novel therapeutic target for NPC.
authors.affiliation: Department of Internal Medicine and Hyperbaric Oxygen, Second Hospital of Longyan City Longyan, Fujian, 364000, PR China.
authors.forename: Tinghua
authors.initials: T
authors.lastname: Yan
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Mindong Hospital of Fujian Medical University Ningde, Fujian, 355000, PR China.
authors.forename: Zhonghao
authors.initials: Z
authors.lastname: Lin
authors.affiliation: The First Clinical Medical College, Fujian Medical University Fuzhou, Fujian, 350001, PR China ; Department of Oncology, Longyan Humanity Hospital Longyan, Fujian, 364000, PR China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Internal Medicine and Hyperbaric Oxygen, Second Hospital of Longyan City Longyan, Fujian, 364000, PR China.
authors.forename: Suiwan
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Mindong Hospital of Fujian Medical University Ningde, Fujian, 355000, PR China.
authors.forename: Miaoan
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine and Hyperbaric Oxygen, Second Hospital of Longyan City Longyan, Fujian, 364000, PR China.
authors.forename: Huaxing
authors.initials: H
authors.lastname: Que
authors.affiliation: Department of Internal Medicine and Hyperbaric Oxygen, Second Hospital of Longyan City Longyan, Fujian, 364000, PR China.
authors.forename: Xiangsheng
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Internal Medicine and Hyperbaric Oxygen, Second Hospital of Longyan City Longyan, Fujian, 364000, PR China.
authors.forename: Ganbo
authors.initials: G
authors.lastname: Que
authors.affiliation: Department of Internal Medicine and Hyperbaric Oxygen, Second Hospital of Longyan City Longyan, Fujian, 364000, PR China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Mao
authors.affiliation: Department of Radiation Oncology, Second Hospital of Longyan City Longyan, Fujian, 364000, PR China.
authors.forename: Jinan
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Radiation Oncology, Second Hospital of Longyan City Longyan, Fujian, 364000, PR China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Zheng
keywords: Matrix metalloproteinase 14; biomarker; epithelial-mesenchymal transition; metastasis; nasopharyngeal carcinoma