title: Endometrial stromal sarcoma with endometrioid adenocarcinoma of the uterus: a case report.
abstract: Endometrial stromal sarcoma (ESS) is a rare malignant neoplasm of the uterus. We report the first case of undifferentiated ESS (UES) coexistent with grade 1 endometrioid adenocarcinoma in a 73-year-old female who presented with irregular vaginal bleeding for 4 days after menopause 20 years. Imaging examination including Magnetic Resonance Imaging (MRI) demonstrated multi-node reflection in uterine cavity without metastatic lesions, and the endometrium essentially normal. Grossly, a grey-red breakable polypoid tumor of 4.5×3.0×2.0 cm was recognized in the posterior uterine wall with surrounding slight rough endometrium. Microscopically, the tumor was composed of a larger component of undifferentiated stromal sarcoma that was distinct from a smaller endometrioid adenocarcinoma. The separate components of the tumor could be supported in immunohistochemical studies. There was no sign of recurrence for postoperative 6 months.
authors.affiliation: Department of Pathology, The Third Central Hospital of Tianjin Medical University, Key Laboratory of Artificial Cell Tianjin 300170, China.
authors.forename: Guiqiu
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Pathology, The Third Central Hospital of Tianjin Medical University, Key Laboratory of Artificial Cell Tianjin 300170, China.
authors.forename: Chuanshan
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The Third Central Hospital of Tianjin Medical University, Key Laboratory of Artificial Cell Tianjin 300170, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Pathology, The Third Central Hospital of Tianjin Medical University, Key Laboratory of Artificial Cell Tianjin 300170, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The Third Central Hospital of Tianjin Medical University, Key Laboratory of Artificial Cell Tianjin 300170, China.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Liu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018269:Carcinoma, Endometrioid / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D060787:Neoplasm Grading; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018203:Sarcoma, Endometrial Stromal / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor
keywords: Uterus; immunohistochemistry; stromal tumor