title: Intraductal papillary neoplasm of the bile duct, gastric type, arising in the intrapancreatic common bile duct could progress to colloid carcinoma: report of a case.
abstract: Intraductal papillary neoplasm of the bile duct (IPNB) exists in a pathway of multistep-carcinogenesis toward cholangiocarcinoma. Four subtypes are observed in IPNB, pancreatobiliary type, intestinal type, gastric type, and oncocytic type, similarly to the corresponding disease in the pancreas, intraductal papillary mucinous neoplasm (IPMN). IPNB can present with or without macroscopically visible mucin secretion. IPNB usually progresses to tubular adenocarcinoma. However, there are a limited number of well-described cases of gastric-type IPNB progressing not to tubular adenocarcinoma but to colloid carcinoma. Herein, we present a case of an 82-year-old female patient with gastric-type IPNB in the intrapancreatic common bile duct without macroscopically visible mucin secretion, which progressed to colloid carcinoma. As IPNB, especially without visible mucin secretion, is considered to be a heterogeneous group of diseases, such an unexpected association could occur.
authors.affiliation: Department of Pathology, Graduate School of Medicine, The University of Tokyo Tokyo, Japan ; Department of Pathology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Tajima
authors.affiliation: Department of Gastroenterology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ohata
authors.affiliation: Department of Pathology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Koda
authors.affiliation: Department of Gastroenterology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D003135:Common Bile Duct / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D016577:Pancreaticoduodenectomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Intraductal papillary neoplasm of the bile duct; colloid carcinoma; gastric type; intraductal papillary mucinous neoplasm