title: Polysaccharide-porphyrin-fullerene supramolecular conjugates as photo-driven DNA cleavage reagents.
abstract: Two water-soluble polysaccharide-porphyrin-fullerene supramolecular conjugates were constructed from the non-covalent incorporation of triphenyl Zn-porphyrin-modified β-cyclodextrins, adamantyl-modified hyaluronate and C60. Significantly, these supramolecular conjugates, which exist as cross-linked or discrete nanoparticles with a diameter of 50-200 nm, can completely cleave closed supercoiled DNA to nicked DNA under light irradiation.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. yuliu@nankai.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Di
authors.initials: D
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage / Q000528:radiation effects; D037741:Fullerenes / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes / Q000528:radiation effects*; D011134:Polysaccharides / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D037741:Fullerenes; D008665:Metalloporphyrins; D011134:Polysaccharides; D004247:DNA; C069837:fullerene C60