title: Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro-odontosarcoma of the maxilla.
abstract: Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15-year-old female with multiple recurrent AFOS. She responded to chemotherapy with ifosfamide and doxorubicin consolidated by stereotactic reirradiation using cyberknife and remained in complete remission 14 months from the end of reirradiation therapy. Chemotherapy with ifosfamide and doxorubicin should be considered in advanced cases of AFOS.
authors.affiliation: Children & Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK.
authors.forename: Susanne A
authors.initials: SA
authors.lastname: Gatz
authors.affiliation: Department of Pathology, The Royal Marsden NHS Foundation Trust, Sutton, UK.
authors.forename: Khin
authors.initials: K
authors.lastname: Thway
authors.affiliation: Department of Radiotherapy, The Royal Marsden NHS Foundation Trust, Sutton, UK.
authors.forename: Henry
authors.initials: H
authors.lastname: Mandeville
authors.affiliation: Head and Neck Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Kerawala
authors.affiliation: Department of Radiology, The Royal Marsden NHS Foundation Trust, Sutton, UK.
authors.forename: David
authors.initials: D
authors.lastname: MacVicar
authors.affiliation: Children & Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK.
authors.forename: Julia
authors.initials: J
authors.lastname: Chisholm
mesh_terms: D000564:Ameloblastoma / Q000601:surgery*; D002648:Child; D005260:Female; D005354:Fibrosarcoma / Q000601:surgery*; D006801:Humans; D008441:Maxillary Neoplasms / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D016634:Radiosurgery; D012074:Remission Induction
keywords: ameloblastic fibro-odontoma; ameloblastic fibro-odontosarcoma; chemotherapy response; radiotherapy; relapse; transformation