title: Treatment of canine generalized demodicosis using weekly injections of doramectin: 232 cases in the USA (2002-2012).
abstract: BACKGROUND
  Generalized demodicosis is a severe skin disease in the dog, with limited treatment options.
  
  
  OBJECTIVE
  To demonstrate that doramectin, when given at a dose rate of 0.6 mg/kg body weight, is a safe and effective treatment for generalized demodicosis in the dog.
  
  
  METHODS
  Four hundred client-owned dogs diagnosed with generalized demodicosis at one general small-animal practice. Of these, 232 completed their treatment and were included in the study.
  
  
  METHODS
  A retrospective study was carried out by searching the computerised medical records of dogs seen at one general small-animal practice in Tennessee, USA. The records of each dog with a diagnosis of generalized demodicosis, who underwent treatment using weekly injections of doramectin at a dose rate of 0.6 mg/kg body weight, were analysed.
  
  
  RESULTS
  Remission was achieved in 94.8% of dogs treated with weekly subcutaneous injections of doramectin at a dose rate of 0.6 mg/kg body weight. Adverse events were rare with two suspected instances (0.5%) being recorded. The mean duration of treatment was 7.1 weeks.
  
  
  CONCLUSIONS
  Doramectin given at a dose rate of 0.6 mg/kg body weight by subcutaneous injection at weekly intervals is a useful and well-tolerated treatment for generalized demodicosis in the dog.
authors.affiliation: Dermatology for Animals, 263 Appleby Road, Stafford Heights, Queensland, 4053, Australia.
authors.forename: John H C
authors.initials: JH
authors.lastname: Hutt
authors.affiliation: Murphy Road Animal Hospital, 4408 Murphy Road, Nashville, TN, 37209, USA.
authors.forename: I Craig
authors.initials: IC
authors.lastname: Prior
authors.affiliation: Dermatology for Animals, 263 Appleby Road, Stafford Heights, Queensland, 4053, Australia.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Shipstone
mesh_terms: D056810:Acaricides / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs / Q000469:parasitology; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D012189:Retrospective Studies; D013714:Tennessee
chemical_list: D056810:Acaricides; D007559:Ivermectin; C084101:doramectin