title: Synthetic Strategies Toward DNA-Coated Colloids that Crystallize.
abstract: We report on synthetic strategies to fabricate DNA-coated micrometer-sized colloids that, upon thermal annealing, self-assemble into various crystal structures. Colloids of a wide range of chemical compositions, including poly(styrene), poly(methyl methacrylate), titania, silica, and a silica-methacrylate hybrid material, are fabricated with smooth particle surfaces and a dense layer of surface functional anchors. Single-stranded oligonucleotides with a short sticky end are covalently grafted onto particle surfaces employing a strain-promoted alkyne-azide cycloaddition reaction resulting in DNA coatings with areal densities an order of magnitude higher than previously reported. Our approach allows the DNA-coated colloids not only to aggregate upon cooling but also to anneal and rearrange while still bound together, leading to the formation of colloidal crystal compounds when particles of different sizes or different materials are combined.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Zheng
authors.forename: Étienne
authors.initials: É
authors.lastname: Ducrot
authors.affiliation: School of Chemical Engineering, Sungkyunkwan University , Suwon 440746, Republic of Korea.
authors.forename: Myung-Goo
authors.initials: MG
authors.lastname: Lee
authors.affiliation: School of Chemical Engineering, Sungkyunkwan University , Suwon 440746, Republic of Korea.
authors.forename: Gi-Ra
authors.initials: GR
authors.lastname: Yi
authors.forename: Marcus
authors.initials: M
authors.lastname: Weck
authors.affiliation: Department of Chemical & Biomolecular Engineering, Polytechnic School of Engineering, New York University , Brooklyn, New York 11201, United States.
authors.forename: David J
authors.initials: DJ
authors.lastname: Pine
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D003102:Colloids; D003460:Crystallization; D061565:Cycloaddition Reaction; D004247:DNA / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D017646:Organosilicon Compounds / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D003102:Colloids; D008689:Methacrylates; D017646:Organosilicon Compounds; D011137:Polystyrenes; C009495:titanium dioxide; D012822:Silicon Dioxide; D004247:DNA; D019904:Polymethyl Methacrylate; D014025:Titanium; C505504:3-(trimethoxysilyl)propyl methacrylate