title: Decreases in perceived maternal criticism predict improvement in subthreshold psychotic symptoms in a randomized trial of family-focused therapy for individuals at clinical high risk for psychosis.
abstract: Perceived criticism (PC) is a measure of how much criticism from 1 family member "gets through" to another. PC ratings have been found to predict the course of psychotic disorders, but questions remain regarding whether psychosocial treatment can effectively decrease PC, and whether reductions in PC predict symptom improvement. In a sample of individuals at high risk for psychosis, we examined a) whether Family Focused Therapy for Clinical High-Risk (FFT-CHR), an 18-session intervention that consists of psychoeducation and training in communication and problem solving, brought about greater reductions in perceived maternal criticism, compared to a 3-session family psychoeducational intervention; and b) whether reductions in PC from baseline to 6-month reassessment predicted decreases in subthreshold positive symptoms of psychosis at 12-month follow-up. This study was conducted within a randomized controlled trial across 8 sites. The perceived criticism scale was completed by 90 families prior to treatment and by 41 families at 6-month reassessment. Evaluators, blind to treatment condition, rated subthreshold symptoms of psychosis at baseline, 6- and 12-month assessments. Perceived maternal criticism decreased from pre- to posttreatment for both treatment groups, and this change in criticism predicted decreases in subthreshold positive symptoms at 12-month follow-up. This study offers evidence that participation in structured family treatment is associated with improvement in perceptions of the family environment. Further, a brief measure of perceived criticism may be useful in predicting the future course of attenuated symptoms of psychosis for CHR youth.
authors.affiliation: Department of Psychiatry, University of California, Los Angeles, School of Medicine.
authors.forename: Mary P
authors.initials: MP
authors.lastname: O'Brien
authors.affiliation: Department of Psychiatry, University of California, Los Angeles, School of Medicine.
authors.forename: David J
authors.initials: DJ
authors.lastname: Miklowitz
authors.affiliation: Department of Psychiatry, University of California, Los Angeles.
authors.forename: Tyrone D
authors.initials: TD
authors.lastname: Cannon
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005196:Family Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009034:Mother-Child Relations / Q000523:psychology*; D009035:Mothers / Q000523:psychology* / Q000706:statistics & numerical data; D010465:Perception; D011618:Psychotic Disorders / Q000523:psychology* / Q000628:therapy*; D012306:Risk; D016896:Treatment Outcome; D055815:Young Adult