title: PAX5-expressing ALK-negative anaplastic large cell lymphoma with extensive extranodal and nodal involvement.
abstract: A 55-year-old man with a history of well controlled HIV infection was admitted with acute renal impairment, peripheral oedema, constitutional symptoms, deranged liver function and hypercalcaemia. Core biopsies of a retroperitoneal mass demonstrated anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma (ALCL) with unusual Paired box 5 (PAX5) positivity. The same malignant cells were identifiable on urine cytology. Staging investigations revealed extensive nodal and extranodal disease including ALK negative ALCL involving the kidney and prostate, which has not previously been reported in the published literature.
authors.affiliation: Department of Pathology (Haematology) and Clinical Haematology, Alfred Health, Melbourne, Victoria, Australia.
authors.forename: Doen Ming
authors.initials: DM
authors.lastname: Ong
authors.affiliation: Department of Pathology (Haematology) and Clinical Haematology, Alfred Health, Melbourne, Victoria, Australia.
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Cummins
authors.affiliation: Department of Anatomical Pathology, Alfred Health, Melbourne, Victoria, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Pham
authors.affiliation: Alfred Pathology Service, Alfred Health, Melbourne, Victoria, Australia Department of Haematology, Monash Health, Clayton, Victoria, Australia.
authors.forename: George
authors.initials: G
authors.lastname: Grigoriadis
mesh_terms: D058186:Acute Kidney Injury; D000077548:Anaplastic Lymphoma Kinase; D001706:Biopsy; D003581:Cytodiagnosis; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006934:Hypercalcemia; D007668:Kidney; D008099:Liver; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D051757:PAX5 Transcription Factor / Q000378:metabolism*; D011467:Prostate; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*
chemical_list: D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases