title: The microRNA-183 cluster: the family that plays together stays together.
abstract: The microRNA (miR)183 cluster, which is comprised of miRs-183, -96 and -182, is also a miR family with sequence homology. Despite the strong similarity in the sequences of these miRs, minute differences in their seed sequences result in both overlapping and distinct messenger RNA targets, which are often within the same pathway. These miRs have tightly synchronized expression during development and are required for maturation of sensory organs. In comparison to their defined role in normal development, the miR-183 family is frequently highly expressed in a variety of non-sensory diseases, including cancer, neurological and auto-immune disorders. Here, we discuss the conservation of the miR-183 cluster and the functional role of this miR family in normal development and diseases. We also describe the regulation of vital cellular pathways by coordinated expression of these miR siblings. This comprehensive review sheds light on the likely reasons why the genomic organization and seeming redundancy of the miR-183 family cluster was conserved through 600 million years of evolution.
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA.
authors.forename: Shweta
authors.initials: S
authors.lastname: Dambal
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA.
authors.forename: Mit
authors.initials: M
authors.lastname: Shah
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA.
authors.forename: Brittany
authors.initials: B
authors.lastname: Mihelich
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA University of Illinois Cancer Center, Chicago, IL 60612, USA lnonn@uic.edu.
authors.forename: Larisa
authors.initials: L
authors.lastname: Nonn
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics; D005786:Gene Expression Regulation; D048788:Growth and Development / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D005810:Multigene Family
chemical_list: C533449:MIRN183 microRNA, human; C541492:MIRN96 microRNA, human; D035683:MicroRNAs; C538984:Mirn182 microRNA, human