title: New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix.
abstract: Five new scalarane sesterterpenoids, felixins A-E (1-5), were isolated from the Formosan sponge Ircinia felix. The structures of scalaranes 1-5 were elucidated on the basis of spectroscopic analysis. Cytotoxicity of scalaranes 1-5 against the proliferation of a limited panel of tumor cell lines was evaluated.
authors.affiliation: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. spire0123456@yahoo.com.tw.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. spire0123456@yahoo.com.tw.
authors.forename: Ya-Yuan
authors.initials: YY
authors.lastname: Lai
authors.affiliation: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.affiliation: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. wanglh@nmmba.gov.tw.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. wanglh@nmmba.gov.tw.
authors.forename: Li-Hsueh
authors.initials: LH
authors.lastname: Wang
authors.affiliation: Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.affiliation: School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.|Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan; D013729:Terpenes / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D054830:Sesterterpenes; D013729:Terpenes
keywords: Ircinia felix; cytotoxicity; scalarane; sesterterpenoid; sponge