title: Soluble type III TGFβ receptor in diagnosis and follow-up of patients with breast cancer.
abstract: Type III transforming growth factor (TGFβ) receptor (TGFβrIII) modulates TGFβ superfamily signaling. Its tumor tissue expression is downregulated in human breast cancer. We determined (indirect ELISA) plasma levels of the soluble receptor (sTGFβrIII) in 47 women with breast cancer (AJCC stages 0-IIB) (cases) pre-surgery and over two months after the surgery, and in 36 healthy women (controls). Plasma sTBFβrIII was lower in cases than in the controls (age-adjusted difference -29.7 ng/mL, p < 0.001), and discriminated between disease and health (sensitivity and specificity 100% at 16.6 ng/mL). With adjustment for age, AJCC stage, lymph node involvement, HER2 and hormone receptor status, higher pre-surgery sTBFβrIII was associated with better progression-free survival (HR = 0.68, 95%CI 0.49-0.89, p = 0.004). An increasing trend in plasma sTBFβrIII was observed over 2 months after the surgery (0.6% increase/day, p < 0.001), consistently across the patient subsets. Data suggest a high potential of plasma sTBFβrIII as a novel diagnostic and prognostic biomarker in breast cancer.
authors.affiliation: a Department of Surgery , General Hospital , Slavonski Brod , Croatia .
authors.forename: Darko
authors.initials: D
authors.lastname: Jurisic
authors.affiliation: b Laboratory for Mineralized Tissues , Center for Translational and Clinical Research, School of Medicine, University of Zagreb , Croatia .
authors.forename: Igor
authors.initials: I
authors.lastname: Erjavec
authors.affiliation: c Department of Pharmacology , School of Medicine, University of Zagreb , Croatia .
authors.forename: Vladimir
authors.initials: V
authors.lastname: Trkulja
authors.affiliation: b Laboratory for Mineralized Tissues , Center for Translational and Clinical Research, School of Medicine, University of Zagreb , Croatia .
authors.forename: Ivo
authors.initials: I
authors.lastname: Dumic-Cule
authors.affiliation: d Department of Cardiology , General Hospital , Slavonski Brod , Croatia , and.
authors.forename: Irzal
authors.initials: I
authors.lastname: Hadzibegovic
authors.affiliation: b Laboratory for Mineralized Tissues , Center for Translational and Clinical Research, School of Medicine, University of Zagreb , Croatia .
authors.forename: Lucija
authors.initials: L
authors.lastname: Kovacevic
authors.affiliation: b Laboratory for Mineralized Tissues , Center for Translational and Clinical Research, School of Medicine, University of Zagreb , Croatia .
authors.forename: Tomo
authors.initials: T
authors.lastname: Svagusa
authors.affiliation: e Department of Plastic Reconstructive and Aesthetic Surgery , University Hospital Dubrava , Zagreb , Croatia.
authors.forename: Zdenko
authors.initials: Z
authors.lastname: Stanec
authors.affiliation: b Laboratory for Mineralized Tissues , Center for Translational and Clinical Research, School of Medicine, University of Zagreb , Croatia .
authors.forename: Slobodan
authors.initials: S
authors.lastname: Vukicevic
authors.affiliation: b Laboratory for Mineralized Tissues , Center for Translational and Clinical Research, School of Medicine, University of Zagreb , Croatia .
authors.forename: Lovorka
authors.initials: L
authors.lastname: Grgurevic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D011509:Proteoglycans / Q000097:blood* / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D018125:Receptors, Transforming Growth Factor beta / Q000097:blood* / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D011509:Proteoglycans; D018719:Erb-b2 Receptor Tyrosine Kinases; D018125:Receptors, Transforming Growth Factor beta; C071736:betaglycan; C508053:ERBB2 protein, human
keywords: TGFβ; TGFβrIII; betaglycan; biomarker; breast cancer