title: Taking the brakes off telomerase.
abstract: Studies using human embryonic stem cells have revealed how common cancer-associated mutations exert their effect on telomerase after cells differentiate into more specialized cell types.
authors.affiliation: Department of Genetics, Brigham and Women's Hospital, Boston, United States.
authors.forename: Kamila
authors.identifier: http://orcid.org/0000-0001-7744-5110
authors.initials: K
authors.lastname: Naxerova
authors.affiliation: Department of Genetics, Brigham and Women's Hospital, Boston, United States.
authors.forename: Stephen J
authors.identifier: http://orcid.org/0000-0001-7923-6283
authors.initials: SJ
authors.lastname: Elledge
mesh_terms: D049109:Cell Proliferation; D006801:Humans; D009154:Mutation; D011401:Promoter Regions, Genetic; D019098:Telomerase / Q000096:biosynthesis*
chemical_list: D019098:Telomerase
keywords: cancer mechanism; chromosomes; developmental biology; genes; genome editing; human; immortalization; ssociated systems 9 CAS9; stem cells; telomerase TERT; tumor spectrum