title: Anaphylaxis to gonadorelin acetate in a girl with central precocious puberty.
abstract: Gonadotropin-releasing hormone analogues are generally regarded as safe drugs. Gonadorelin acetate has been widely used for the diagnosis of central precocious puberty, and life-threatening reactions to gonadorelin acetate are extremely rare. Herein, we described - to the best of our knowledge - the first pediatric case in which severe anaphylaxis was encountered after intravenous gonadorelin acetate administration. An 8-year-old girl who was diagnosed with central precocious puberty was receiving triptorelin acetate treatment uneventfully for 6 months. In order to evaluate the efficacy of the treatment, an LH-RH stimulation test with gonadorelin acetate was planned. Within 3 min after intravenous administration of gonadorelin acetate, she lost consciousness and tonic seizures began in her hands and feet. She was immediately treated with epinephrine, diphenhydramine, and fluids. Her vital signs recovered within 30 min. Based on the results, anaphylaxis should be anticipated and the administration of these drugs should be performed in a setting that is equipped to deal with systemic reactions.
authors.forename: Onur
authors.initials: O
authors.lastname: Akın
authors.forename: Süleyman Tolga
authors.initials: ST
authors.lastname: Yavuz
authors.forename: Bülent
authors.initials: B
authors.lastname: Hacıhamdioğlu
authors.forename: Erkan
authors.initials: E
authors.lastname: Sarı
authors.forename: Orhan
authors.initials: O
authors.lastname: Gürsel
authors.forename: Ediz
authors.initials: E
authors.lastname: Yeşilkaya
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy; D002648:Child; D004155:Diphenhydramine / Q000627:therapeutic use; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D011629:Puberty, Precocious / Q000188:drug therapy*
chemical_list: D006634:Histamine H1 Antagonists; D007987:Gonadotropin-Releasing Hormone; D004155:Diphenhydramine; D004837:Epinephrine