title: Incidence of Cyclophosphamide-induced Urotoxicity and Protective Effect of Mesna in Rheumatic Diseases.
abstract: OBJECTIVE
  To assess bladder toxicity of cyclophosphamide (CYC) and uroprotective effect of mesna in rheumatic diseases.
  
  
  METHODS
  Data of 1018 patients (725 women/293 men) treated with CYC were evaluated in this retrospective study. All of the following information was obtained: the cumulative CYC dose, route of CYC administration, duration of therapy, concomitant mesna usage, and hemorrhagic cystitis. Cox proportional hazard model was used for statistics.
  
  
  RESULTS
  We identified 17 patients (1.67%) with hemorrhagic cystitis and 2 patients (0.19%) with bladder cancer in 4224 patient-years. The median time for diagnosis to hemorrhagic cystitis was 10 months (4-48) and bladder cancer was 8 years (6-10.9). There were 583 patients (57.2%) who received mesna with intravenous CYC therapy. We observed similar incidence rate for hemorrhagic cystitis in both patient groups concomitantly treated with or without mesna [9/583 (1.5%) vs 8/425 (1.8%) respectively, p = 0.08]. Cumulative CYC dose (HR for 10-g increments 1.24, p < 0.001) was associated with hemorrhagic cystitis.
  
  
  CONCLUSIONS
  Cumulative dose was the only risk factor for hemorrhagic cystitis in patients treated with CYC. No proof was obtained for the uroprotective effect of mesna in our cohort.
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Neslihan
authors.initials: N
authors.lastname: Yilmaz
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Hakan
authors.initials: H
authors.lastname: Emmungil
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Sercan
authors.initials: S
authors.lastname: Gucenmez
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Gulsen
authors.initials: G
authors.lastname: Ozen
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Fatih
authors.initials: F
authors.lastname: Yildiz
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Ayşe
authors.initials: A
authors.lastname: Balkarli
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Gezmis
authors.initials: G
authors.lastname: Kimyon
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Belkis Nihan
authors.initials: BN
authors.lastname: Coskun
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Ismail
authors.initials: I
authors.lastname: Dogan
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Omer Nuri
authors.initials: ON
authors.lastname: Pamuk
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Sule
authors.initials: S
authors.lastname: Yasar
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Gozde Yildirim
authors.initials: GY
authors.lastname: Cetin
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Ayten
authors.initials: A
authors.lastname: Yazici
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Serpil
authors.initials: S
authors.lastname: Ergulu Esmen
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Yonca
authors.initials: Y
authors.lastname: Cagatay
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Sema
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Ayse
authors.initials: A
authors.lastname: Cefle
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sayarlioglu
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Timucin
authors.initials: T
authors.lastname: Kasifoglu
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Omer
authors.initials: O
authors.lastname: Karadag
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Pehlivan
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Ediz
authors.initials: E
authors.lastname: Dalkilic
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Kisacik
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Veli
authors.initials: V
authors.lastname: Cobankara
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Eren
authors.initials: E
authors.lastname: Erken
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Kenan
authors.initials: K
authors.lastname: Aksu
authors.affiliation: From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, İzmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana; Rheumatology Department, Faculty of Medicine, Pamukkale University, Denizli; Faculty of Medicine, Gaziantep Rheumatology University, Gaziantep; Rheumatology Department, Faculty of Medicine, Uludag University, Bursa; Rheumatology Department, Faculty of Medicine, Hacettepe University, Ankara; Rheumatology Department, Faculty of Medicine, Trakya University, Edime; Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir; Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaraş; Rheumatology Department, Faculty of Medicine, Kocaeli University, İzmit; Rheumatology Department, Faculty of Medicine, Selçuk University, Konya, Turkey.N. Yilmaz, MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; H. Emmungil, MD; S. Gucenmez, MD, Rheumatology Department, Faculty of Medicine, Ege University; G. Ozen, MD, Rheumatology Department, Faculty of Medicine, Marmara University; F. Yildiz, MD, Rheumatology Department, Faculty of Medicine, Cukurova University; A. Balkarli, MD, Rheumatology Department, Faculty of Medicine, Pamukkale University; G. Kimyon, MD, Faculty of Medicine, Gaziantep Rheumatology University; B.N. Coskun, MD, Rheumatology Department, Faculty of Medicine, Uludag University; I. Dogan, MD, Rheumatology Department, Faculty of Medicine, Hacettepe University; O.N. Pamuk, MD, Rheumatology Department, Faculty of Medicine, Trakya University; S. Yasar, MD, Rheumatology Department, Faculty of Medicine, Eskişehir Osmangazi University; G.Y. Cetin, MD, Rheumatology Department, Faculty of Medicine, Kahramanmaraş Sütçüimam University; A. Yazici, MD, Associate
authors.forename: Sule
authors.initials: S
authors.lastname: Yavuz
mesh_terms: D000328:Adult; D000368:Aged; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D003556:Cystitis / Q000139:chemically induced / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D015080:Mesna / Q000627:therapeutic use*; D008875:Middle Aged; D020011:Protective Agents / Q000627:therapeutic use*; D012216:Rheumatic Diseases / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D020011:Protective Agents; D003520:Cyclophosphamide; D015080:Mesna
keywords: HEMORRHAGIC CYSTITIS; MESNA; RHEUMATIC DISEASES