title: [Efficacy analysis of endoscopic endonasal transsphenoidal surgery for recurrent or regrowing pituitary adenomas].
abstract: OBJECTIVE
  To analyze the safety and efficacy of surgical removal of recurrent or regrowing pituitary adenomas by endoscopic endonasal transsphenoidal approach.
  
  
  METHODS
  The clinical data were retrospectively reviewed for 28 patients undergoing endoscopic endonasal transsphenoidal surgery for recurrent or regrowing pituitary adenomas between April 2010 and December 2013. There were 9 males and 19 females with a mean age of 44. 2 (11 - 73) years. The maximal tumor diameter ranged from 2. 1 to 6.9 cm. The Knosp grades were 1 -2 (n = 11), 3 (n =8) and 4 (n =9). Fifteen tumors were endocrinically functional and the remainder endocrinically nonfunctional. All operations were performed with an assistance of intraoperative neuronavigation. Neuro-ophthalmological, neuroimaging and endocrinological results were followed up postoperatively. And surgical outcomes and risk factors were analyzed for incomplete tumor resection in previous operations.
  
  
  RESULTS
  The mean follow-up period was 19. 1 (3 - 45) months. Gross total resection(n = 18, 64. 3%), subtotal resection(n = 6, 21. 4%) and partial resection(n = 4, 14. 3%) were achieved. Postoperatively, visual acuity improved in 11 patients (73. 3%) and 6 patients (40. 0%) showed endocrine remission. Qne patient had short-term postoperative leakage of cerebrospinal fluid (CSF).
  
  
  CONCLUSIONS
  Endoscopic endonasal transsphenoidal surgery is both safe and effective for recurrent or regrowing pituitary adenomas.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Xue
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Daming
authors.initials: D
authors.lastname: Cui
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Zhaoli
authors.initials: Z
authors.lastname: Shen
authors.forename: Rui
authors.initials: R
authors.lastname: Shen
authors.forename: Meiqing
authors.initials: M
authors.lastname: Lou
mesh_terms: D000236:Adenoma; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D038361:Neuronavigation; D009666:Nose; D010911:Pituitary Neoplasms; D011183:Postoperative Complications; D011184:Postoperative Period; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult