title: Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis.
abstract: Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (Parps) family for post-translational modification in cellular process. Being a major member of Parps, Parp1 is a crucial nuclear factor with biological significance in modulating DNA repair, DNA replication, transcription, DNA methylation and chromatin remodeling through PARylation of downstream proteins. In addition, high expression level and activity of Parp1 are correlated with pluripotent status, reprogramming, and cancer. Furthermore, epigenetic modulation of Parp1 is explored for regulating wide variety of gene expression. Genetic and pharmaceutical disruption of Parp1 further confirmed the importance of Parp1 in cell growth, DNA repair, and reprogramming efficiency. Taken together, the proximity toward the understanding of the modulation of Parp1 including interaction and modification in different fields will provide new insight for future studies. In this review, the biological significance of Parp1 in transcription and the epigenetic modulation of Parp1 in pluripotent status, reprogramming process and cancer will be summarized.
authors.affiliation: Institute of Oral Biology, National Yang-Ming University, Taipei 112, Taiwan. lovelace831124@yahoo.com.tw.
authors.forename: Bo-Hua
authors.initials: BH
authors.lastname: Jiang
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. jan740709@gmail.com.|Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan. jan740709@gmail.com.
authors.forename: Wei-Lien
authors.initials: WL
authors.lastname: Tseng
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. doc3643h@yahoo.com.tw.|Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. doc3643h@yahoo.com.tw.|Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. doc3643h@yahoo.com.tw.
authors.forename: Hsin-Yang
authors.initials: HY
authors.lastname: Li
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. monglien@gmail.com.|VGH-YM Genomic Research Center, National Yang-Ming University, Taipei 112, Taiwan. monglien@gmail.com.
authors.forename: Mong-Lien
authors.initials: ML
authors.lastname: Wang
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. ylchang@vghtpe.gov.tw.|Department of Pharmacy, Taipei Veterans General Hospital, Taipei 112, Taiwan. ylchang@vghtpe.gov.tw.
authors.forename: Yuh-Lih
authors.initials: YL
authors.lastname: Chang
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. yjsung@ym.edu.tw.|Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. yjsung@ym.edu.tw.
authors.forename: Yen-Jen
authors.initials: YJ
authors.lastname: Sung
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. shchiou@vghtpe.gov.tw.|Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan. shchiou@vghtpe.gov.tw.|Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. shchiou@vghtpe.gov.tw.
authors.forename: Shih-Hwa
authors.initials: SH
authors.lastname: Chiou
mesh_terms: D063646:Carcinogenesis; D065150:Cellular Reprogramming; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D004260:DNA Repair; D006801:Humans; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D011065:Poly(ADP-ribose) Polymerases
keywords: PARylation; Parp1; pluripotency; reprogramming; tumorogenesis