title: Association between E-cadherin (CDH1) polymorphisms and pancreatic cancer risk in Han Chinese population.
abstract: This study was designed to investigate the associations between E-cadherin (CDH1) gene polymorphisms and pancreatic cancer (PC) risk predisposition. We undertook a case-control study to analyze three E-cadherin polymorphisms (+54T>C, -160C>A and -347G→GA) in an Han Chinese population, by extraction of genomic DNA from the peripheral blood of 368 patients with PC and 376 control participants and performed E-cadherin genotyping using DNA sequencing. Overall, no statistically significant association was observed in +54T>C. Nevertheless, -347G→GA genotype was at increased risk of PC (P=0.022; odds ratio (OR)=1.128, CI 95%: 1.017-1.251). Furthermore, -347GA/GA genotype pancreatic cancers were more significantly common in cases of advanced T stage, lymph node metastasis and clinical pathological stage than G or G/GA genotypes PC. However, -160C>A genotype demonstrated a protective effect in PCs (P=0.017; OR=0.883, CI 95%: 0.798-0.977). In conclusion, polymorphism in -347G→GA was observed to be associated with susceptibility of PC. However, -160C>A polymorphism indicated to play a protective role in susceptibility to PC. Nevertheless, further investigation with a larger sample size is needed to support our results.
authors.affiliation: Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Guangzhou, China ; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou, China.
authors.forename: Ying-Xue
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Guangzhou, China ; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Mian
authors.initials: M
authors.lastname: Xi
authors.affiliation: Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Guangzhou, China ; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Shi-Liang
authors.initials: SL
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Guangzhou, China ; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Guangzhou, China ; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Luo
authors.affiliation: Department of Radiation Oncology, Sun Yat-Sen University Cancer Center Guangzhou, China ; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Meng-Zhong
authors.initials: MZ
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD; D044466:Asian People / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins
keywords: E-cadherin; Pancreatic cancer; allele; polymorphism