title: A Luminogen with Aggregation-Induced Emission Characteristics for Wash-Free Bacterial Imaging, High-Throughput Antibiotics Screening and Bacterial Susceptibility Evaluation.
abstract: A luminogen with aggregation-induced emission characteristics is reported for bacterial imaging and antibiotics screening studies. The luminogen can light up bacteria in a wash-free manner, which simplifies the imaging process and increases its accuracy in bacterial detection. It can also be applied to high-throughput screening of antibiotics and fast evaluation of bacterial susceptibility, giving reliable results in less than 5 h.
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Engui
authors.initials: E
authors.lastname: Zhao
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Sijie
authors.initials: S
authors.lastname: Chen
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Haiqin
authors.initials: H
authors.lastname: Deng
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Gui
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Chris W T
authors.initials: CW
authors.lastname: Leung
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Yuning
authors.initials: Y
authors.lastname: Hong
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Jacky W Y
authors.initials: JW
authors.lastname: Lam
authors.affiliation: HKUST Shenzhen Research Institute, Nanshan, Shenzhen, 518057, China.|Division of Biomedical Engineering, Department of Chemistry, Institute for Advanced Study, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.|Guangdong Innovative Research Team, SCUT-HKUST Joint Research Laboratory, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology (SCUT), Guangzhou, 510640, China.
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects*; D057166:High-Throughput Screening Assays; D008856:Microscopy, Fluorescence; D013212:Staphylococcus epidermidis / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents
keywords: aggregation-induced emission; antibiotics screening; bacterial imaging; bacterial susceptibility; high-throughput