title: Observational study of sleep, respiratory mechanics and quality of life in patients with non-cystic fibrosis bronchiectasis: a protocol study.
abstract: BACKGROUND
  Bronchiectasis is a chronic disorder characterised by permanent and irreversible abnormal dilation of the bronchi and bronchioles, primarily caused by repeated cycles of pulmonary infections and inflammation, which lead to reduced mucociliary clearance and to the excessive production of sputum. Patients with non-cystic fibrosis bronchiectasis may be predisposed to hypoxemia during sleep, or to symptoms that may lead to arousals and thereby reduce the quality of life, because of the irreversible dilation of the bronchi and the presence of secretions and airflow obstruction.
  
  
  METHODS
  For this cross-sectional observational study, patients with a clinical diagnosis of non-cystic fibrosis bronchiectasis will be recruited from the Bronchiectasis Clinic of the Pneumology Department of the Santa Casa de Misericordia Hospital and the Federal University of São Paulo (São Paulo, Brazil). Patients of either sex will be included if high-resolution CT of the thorax and classic sweat test confirms they have non-cystic fibrosis bronchiectasis, are between 18 and 80 years old, use long-acting bronchodilators, are clinically stable for a least 1 month, agree to participate in the study and they sign a statement of informed consent. The first part of the study will involve a clinical evaluation, maximal respiratory pressures, spirometry and the Saint George's Respiratory Questionnaire. The Sleep Laboratory of the Master's and Doctoral Postgraduate Program in Rehabilitation Sciences of the Nove de Julho University (São Paulo, Brazil) will perform the polysomnographic studies, Berlin Questionnaire, Epworth Sleepiness Scale, waist and neck circumferences, modified Mallampati classification and tonsil index.
  
  
  BACKGROUND
  This protocol has been approved by the Human Research Ethics Committees of Santa Casa de Misericordia Hospital (process number 178/2012) and Human Research Ethics Committee of Nove de Julho University (process number 370474/2010). All participants will sign a statement of informed consent. The study findings will be published in peer-reviewed journals and presented at conferences.
authors.affiliation: Master and PhD degree in Surgery Research, Santa Casa de São Paulo School of Medicine Sciences, (FCMSCSP), São Paulo, Brazil.
authors.forename: Newton Santos
authors.initials: NS
authors.lastname: Faria Júnior
authors.affiliation: Rehabilitation Sciences Master's and Doctoral Degree Program, Nove de Julho University (UNINOVE), São Paulo, Brazil.
authors.forename: Luis Vicente Franco
authors.initials: LV
authors.lastname: Oliveira
authors.affiliation: Master and PhD degree in Surgery Research, Santa Casa de São Paulo School of Medicine Sciences, (FCMSCSP), São Paulo, Brazil.
authors.forename: Eduardo Araújo
authors.initials: EA
authors.lastname: Perez
authors.affiliation: Rehabilitation Sciences Master's and Doctoral Degree Program, Nove de Julho University (UNINOVE), São Paulo, Brazil.
authors.forename: Ezequiel Fernandes
authors.initials: EF
authors.lastname: de Oliveira
authors.affiliation: Rehabilitation Sciences Master's and Doctoral Degree Program, Nove de Julho University (UNINOVE), São Paulo, Brazil.
authors.forename: Nadua
authors.initials: N
authors.lastname: Apostolico
authors.affiliation: Rehabilitation Sciences Master's and Doctoral Degree Program, Nove de Julho University (UNINOVE), São Paulo, Brazil.
authors.forename: Nixon Alves
authors.initials: NA
authors.lastname: Pereira
authors.affiliation: Rehabilitation Sciences Master's and Doctoral Degree Program, Nove de Julho University (UNINOVE), São Paulo, Brazil.
authors.forename: Israel dos Reis
authors.initials: Idos R
authors.lastname: dos Santos
authors.affiliation: Rehabilitation Sciences Master's and Doctoral Degree Program, Nove de Julho University (UNINOVE), São Paulo, Brazil.
authors.forename: Jessica Julioti
authors.initials: JJ
authors.lastname: Urbano
authors.affiliation: Rehabilitation Sciences Master's and Doctoral Degree Program, Nove de Julho University (UNINOVE), São Paulo, Brazil.
authors.forename: Ismael Dias
authors.initials: ID
authors.lastname: Souza
authors.affiliation: Department of Pneumology, Santa Casa de Misericordia Hospital, São Paulo, Brazil.
authors.forename: Igor Bastos
authors.initials: IB
authors.lastname: Polonio
authors.affiliation: Department of Pneumology, Santa Casa de Misericordia Hospital, São Paulo, Brazil.
authors.forename: José Gustavo Barian
authors.initials: JG
authors.lastname: Romaldini
authors.affiliation: Department of Pneumology, Santa Casa de Misericordia Hospital, São Paulo, Brazil.
authors.forename: Déborah Madeu
authors.initials: DM
authors.lastname: Pereira
authors.affiliation: Department of Pneumology, Santa Casa de Misericordia Hospital, São Paulo, Brazil.
authors.forename: Vera Lúcia dos Santos
authors.initials: VL
authors.lastname: Alves
authors.affiliation: Pulmonary Rehabilitation Center, São Paulo Hospital, Federal University of São Paulo, (UNIFESP), São Paulo, Brazil.
authors.forename: Ângela Honda
authors.initials: ÂH
authors.lastname: Souza
authors.affiliation: Pulmonary Rehabilitation Center, São Paulo Hospital, Federal University of São Paulo, (UNIFESP), São Paulo, Brazil.
authors.forename: Oliver Augusto
authors.initials: OA
authors.lastname: Nascimento
authors.affiliation: Pulmonary Rehabilitation Center, São Paulo Hospital, Federal University of São Paulo, (UNIFESP), São Paulo, Brazil.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Jardim
authors.affiliation: Master and PhD degree in Surgery Research, Santa Casa de São Paulo School of Medicine Sciences, (FCMSCSP), São Paulo, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Stirbulov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001987:Bronchiectasis / Q000503:physiopathology* / Q000523:psychology*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011788:Quality of Life / Q000523:psychology*; D012107:Research Design; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: SLEEP MEDICINE; THORACIC MEDICINE