title: Sepsis of unknown origin with multiorgan failure syndrome: Think of hemophagocytic lymphohistiocytosis.
abstract: Hemophagocytic lymphohistiocytosis is a clinic pathologic entity characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. It is a potentially lethal disorder due to an uncontrolled immune response to a triggering agent. HPS may be primary, or secondary to malignancy, infections, auto-immune diseases, and pharmacotherapy. HPS is a rare, but life-threatening complication. Herein, we described a female patient with HPS with secondary sepsis. Our objective was to raise the importance of early diagnosis of HFS by presenting a representative case.
authors.affiliation: Department of Critical Care and Pulmonology, Fortis Hospital, Mohali, Punjab, India.
authors.forename: Namrata
authors.initials: N
authors.lastname: Maheshwari
authors.affiliation: Department of Critical Care and Pulmonology, Fortis Hospital, Mohali, Punjab, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Mandal
authors.affiliation: Department of Anesthesia and Critical Care, PGIMER, Chandigarh, India.
authors.forename: Neeru
authors.initials: N
authors.lastname: Sahni
keywords: Hemophagocytic lymphohistiocytosis; macrophages; multiorgan failure; sepsis