title: Micro- and nano-force evaluation of bioengineered muscle cells: a non-contact two-dimensional biosensing using surface acoustic wave devices.
abstract: A high degree of cell-generated force measurement is required to evaluate the biomechanical performance of bioengineered muscle tissues. However, the conventional cantilever types of direct force measurement methods have limitations in developing a non-contact two-dimensional force sensing device for a single muscle cell. In this paper, a method is proposed and discussed by using focused surface acoustic wave and magneto-optic Kerr measurements. To depict the capability of the proposed method, a conceptual design of such a sensory device is demonstrated for non-contact two-dimensional force measurement of a single muscle cell.
authors.affiliation: Biomechanics Laboratory Singapore General Hospital, 20 College Road, Academia, Level 1, 169856 Singapore.
authors.forename: Yoke-Rung
authors.initials: YR
authors.lastname: Wong
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D006801:Humans; D055595:Mechanical Phenomena; D055617:Micro-Electrical-Mechanical Systems; D032342:Muscle Cells / Q000502:physiology*; D013016:Sound; D023822:Tissue Engineering