title: Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR-γ Activation in Rats.
abstract: Lonicera japonica Thunb. (Caprifoliaceae) is a traditional herbal medicine and has been used to treat diabetic symptoms. Notwithstanding its use, the scientific basis on anti-diabetic properties of L. japonica is not yet established. This study is designed to investigate anti-diabetic effects of L. japonica in type 2 diabetic rats. L. japonica was orally administered at the dose of 100 mg/kg in high-fat diet-fed and low-dose streptozotocin-induced rats. After the treatment of 4 weeks, L. japonica reduced high blood glucose level and homeostatic model assessment of insulin resistance in diabetic rats. In addition, body weight and food intake were restored by the L. japonica treatment. In the histopathologic examination, the amelioration of damaged β-islet in pancreas was observed in L. japonica-treated diabetic rats. The administration of L. japonica elevated peroxisome proliferator-activated receptor gamma and insulin receptor subunit-1 protein expressions. The results demonstrated that L. japonica had anti-diabetic effects in type 2 diabetic rats via the peroxisome proliferator-activated receptor gamma regulatory action of L. japonica as a potential mechanism.
authors.affiliation: College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, Seoul, 130-701, Korea.
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Han
authors.affiliation: College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, Seoul, 130-701, Korea.
authors.forename: Mi Hye
authors.initials: MH
authors.lastname: Kim
authors.affiliation: College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, Seoul, 130-701, Korea.
authors.forename: You Yeon
authors.initials: YY
authors.lastname: Choi
authors.affiliation: College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, Seoul, 130-701, Korea.
authors.forename: Haesu
authors.initials: H
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Kyung Hee University, Seoul, 130-701, Korea.
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.affiliation: College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, Seoul, 130-701, Korea.
authors.forename: Woong Mo
authors.initials: WM
authors.lastname: Yang
mesh_terms: D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D059305:Diet, High-Fat; D006943:Hyperglycemia / Q000188:drug therapy; D007333:Insulin Resistance; D031239:Lonicera; D008297:Male; D047495:PPAR gamma / Q000378:metabolism*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D013311:Streptozocin
chemical_list: D047495:PPAR gamma; D010936:Plant Extracts; D013311:Streptozocin
keywords: Lonicera japonica Thunb; PPAR-γ; anti-diabetic; anti-hyperglycemic; type 2 diabetes mellitus