title: SOD activity and DNA binding properties of a new symmetric porphyrin Schiff base ligand and its metal complexes.
abstract: 4-Methoxy-2,6-bis(hydroxymethyl)phenol (1) was prepared from the reaction of 4-methoxyphenol and formaldehyde. The compound (1) was then oxidized to the 4-methoxy-2,6-diformylphenol (2) compound. Molecular structure of compound (2) was determined by X-ray diffraction method. A new symmetric porphyrin Schiff base ligand 4-methoxy-2,6-bis[5-(4-iminophenyl)-10,15,20-triphenylporphyrin]phenol (L) was prepared from the reaction of the 5-(4-aminophenyl)-10,15,20-triphenylporphyrin (TTP-NH2) and the compound (2) in the toluene solution. The metal complexes (Cu(II), Fe(III), Mn(III), Pt(II) and Zn(II)) of the ligand (L) were synthesized and characterized by the spectroscopic and analytical methods. The DNA (fish sperm FSdsDNA) binding studies of the ligand and its complexes were performed using UV-vis spectroscopy. Additionally, superoxide dismutase activities of the porphyrin Schiff base metal complexes were investigated. Additionally, electrochemical, photoluminescence and thermal properties of the compounds were investigated.
authors.affiliation: Chemistry Department, K.Maras Sütcü Imam University, 46100 K.Maras, Turkey.
authors.forename: Sevim
authors.initials: S
authors.lastname: Çay
authors.affiliation: Chemistry Department, K.Maras Sütcü Imam University, 46100 K.Maras, Turkey.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Köse
authors.affiliation: Chemistry Department, K.Maras Sütcü Imam University, 46100 K.Maras, Turkey.
authors.forename: Ferhan
authors.initials: F
authors.lastname: Tümer
authors.affiliation: Chemistry Department, K.Maras Sütcü Imam University, 46100 K.Maras, Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Gölcü
authors.affiliation: Chemistry Department, K.Maras Sütcü Imam University, 46100 K.Maras, Turkey. Electronic address: mtumer@ksu.edu.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tümer
mesh_terms: D000818:Animals; D000840:Anisoles / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D008024:Ligands; D008297:Male; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013094:Spermatozoa / Q000502:physiology; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: C548833:5-(4-aminophenyl)-10,15,20-triphenylporphyrin; D000840:Anisoles; D056831:Coordination Complexes; D008024:Ligands; D011166:Porphyrins; D012545:Schiff Bases; C009760:mequinol; D004247:DNA; D013482:Superoxide Dismutase
keywords: DNA-binding; Porphyrin-Schiff base; Spectroscopy; Superoxide dismutase activity