title: Platelet-Rich Plasma in a Patient with Cerebral Palsy.
abstract: BACKGROUND
  The use of platelet-rich plasma is a now a common medical technique known as regenerative medicine, through power cell activation and differentiation, which produces growth factors called platelets derived both locally and systematically. Here, we report the case of a cerebral palsy patient who received intravenous platelet-rich plasma.
  
  
  METHODS
  We administered an intravenous injection of concentrated platelet-rich plasma (25 cc) in a 6-year-old boy with perinatal cerebral palsy, cognitive impairment, and marked and severe generalized spasticity. We performed follow-up at 3 and 6 months after the injection. All serum samples for determination were obtained by ELISA technique. Cognitive scales (Bayley, Battelle, M.S.C.A, Kaufman ABC, and Stanford-Binet Intelligence scale) were used before and after treatment. The determination protocol that was applied before the analysis was performed manually and the autotransfusion was considered suitable for treatment. We determined the plasma levels of factor similar to insulin-1 (IGF-1), platelet-derived growth factor (PDGF), vasculo-endothelial growth factor (VEGF), and transforming growth factor B (TGF-B) before and during treatment monitoring.
  
  
  CONCLUSIONS
  No adverse effects were observed in the patient except for a small hematoma in the area channeling venous access. We observed a clear improvement in the cognitive sphere (memory, ability to perform more complex tasks, and acquisition of new skills) and in language, maintaining stable levels of growth factor in plasma 3-5 times higher than average for his age group at both 3- and 6-month follow-up. Positron emission tomography (PET) images showed an evident increased demarcation in the cerebral cortex. We propose that this therapy is useful in these patients to harness the neurostimulative and neuroregenerative power of endogenous growth factors derived from platelets.
authors.affiliation: Department of Hematology and Oncology, Hospital Mesa del Castillo, Murcia, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Alcaraz
authors.affiliation: Department of Neuroendocrinology, Ruber Hospital, Madrid, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Oliver
authors.affiliation: Department of Hematology and Oncology, Hospital Mesa del Castillo, Murcia, Spain.
authors.forename: Juana María
authors.initials: JM
authors.lastname: Sánchez
mesh_terms: D002547:Cerebral Palsy / Q000000981:diagnostic imaging / Q000523:psychology / Q000628:therapy*; D002648:Child; D006801:Humans; D008297:Male; D053657:Platelet-Rich Plasma; D011859:Radiography