title: Spatial intra-tumour heterogeneity in acquired resistance to targeted therapy complicates the use of PDX models for co-clinical cancer studies.
authors.affiliation: Manchester Cancer Research Centre, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.
authors.forename: Claudia
authors.initials: C
authors.lastname: Wellbrock
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008545:Melanoma / Q000188:drug therapy*; D009154:Mutation; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*; D000077484:Vemurafenib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D013449:Sulfonamides; D000077484:Vemurafenib