title: Intrinsically Mn2+-Chelated Polydopamine Nanoparticles for Simultaneous Magnetic Resonance Imaging and Photothermal Ablation of Cancer Cells.
abstract: Theranostic agents for magnetic resonance imaging (MRI) guided photothermal therapy have attracted intensive interest in cancer diagnosis and treatment. However, the development of biocompatible theranostic agents with high photothermal conversion efficiency and good MRI contrast effect remains a challenge. Herein, PEGylated Mn2+-chelated polydopamine (PMPDA) nanoparticles were successfully developed as novel theranostic agents for simultaneous MRI signal enhancement and photothermal ablation of cancer cells, based on intrinsic manganese-chelating properties and strong near-infrared absorption of polydopamine nanomaterials. The obtained PMPDA nanoparticles showed significant MRI signal enhancement for both in vitro and in vivo imaging. Highly effective photothermal ablation of HeLa cells exposed to PMPDA nanoparticles was then achieved upon laser irradiation for 10 min. Furthermore, the excellent biocompatibility of PMPDA nanoparticles, because of the use of Mn2+ ions as diagnostic agents and biocompatible polydopamine as photothermal agents, was confirmed by a standard MTT assay. Therefore, the developed PMPDA nanoparticles could be used as a promising theranostic agent for MRI-guided photothermal therapy of cancer cells.
authors.affiliation: †School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People's Republic of China.|‡MOE Key Laboratory of Micro-System and Micro-Structures Manufacturing, Harbin Institute of Technology, Harbin 150080, People's Republic of China.
authors.forename: Zhao-Hua
authors.initials: ZH
authors.lastname: Miao
authors.affiliation: §School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: §School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, People's Republic of China.
authors.forename: Huanjie
authors.initials: H
authors.lastname: Yang
authors.affiliation: ∥Condensed Matter Science and Technology Institute, School of Science, Harbin Institute of Technology, Harbin 150000, People's Republic of China.
authors.forename: Zheng-Lin
authors.initials: ZL
authors.lastname: Li
authors.affiliation: †School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People's Republic of China.|‡MOE Key Laboratory of Micro-System and Micro-Structures Manufacturing, Harbin Institute of Technology, Harbin 150080, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhen
authors.affiliation: †School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People's Republic of China.|‡MOE Key Laboratory of Micro-System and Micro-Structures Manufacturing, Harbin Institute of Technology, Harbin 150080, People's Republic of China.
authors.forename: Cheng-Yan
authors.initials: CY
authors.lastname: Xu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry*; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007211:Indoles / Q000737:chemistry*; D007259:Infrared Rays; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000000981:diagnostic imaging; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011859:Radiography; D000068936:Theranostic Nanomedicine; D014183:Transplantation, Heterologous
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D007211:Indoles; D058185:Magnetite Nanoparticles; D011108:Polymers; C568283:polydopamine; D011092:Polyethylene Glycols; D008345:Manganese
keywords: cancer cells; magnetic resonance imaging; photothermal ablation; polydopamine nanoparticles; theranostic agent