title: Deubiquitinating enzymes in cellular signaling and disease regulation.
abstract: Protein post-translational modification by ubiquitin represents a complex signaling system that regulates many cellular events including proteostasis to intercellular communications. Deubiquitinating enzymes (DUBs) that specifically disassemble Ub-chains or regulate ubiquitin homeostasis reside as a central component in ubiquitin signaling. Human genome encodes almost 100 DUBs and majority of them are not well characterized. Considerable progress has been made in the understanding of enzymatic mechanism; however, their cellular substrate specificity and regulation are largely unknown. Involvement of DUBs in disease regulation has been depicted since its discovery and several attempts have been made for evaluating DUBs as a drug target. In this review, we have updated briefly a new insight of DUBs activity, their cellular role, disease regulation, and therapeutic potential.
authors.affiliation: Laboratory of Proteomics and Cellular Signaling, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Bhakri Village, Faridabad, India.
authors.forename: Pranita
authors.initials: P
authors.lastname: Hanpude
authors.affiliation: Laboratory of Proteomics and Cellular Signaling, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Bhakri Village, Faridabad, India.
authors.forename: Sushmita
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Laboratory of Proteomics and Cellular Signaling, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Bhakri Village, Faridabad, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Dey
authors.affiliation: Laboratory of Proteomics and Cellular Signaling, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Bhakri Village, Faridabad, India.
authors.forename: Tushar Kanti
authors.initials: TK
authors.lastname: Maiti
mesh_terms: D004249:DNA Damage; D004260:DNA Repair; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism; D010084:Oxidation-Reduction; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D012269:Ribosomal Proteins / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism*; D013379:Substrate Specificity; D058207:Sumoylation; D025801:Ubiquitin / Q000378:metabolism*; D054875:Ubiquitination; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D004798:Enzymes; C408062:RPS27a protein, human; D012269:Ribosomal Proteins; C479419:UBB protein, human; D025801:Ubiquitin; D014452:Ubiquitins
keywords: cysteine proteases; deubiquitinating enzymes; enzyme mechanisms; neurodegenerative disorders; signaling; ubiquitin-proteasome system