title: Prompt diagnosis and management of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder and hemophagocytosis: A dreaded complication in a post-liver transplant child.
abstract: EBV-associated PTLD is increasingly recognized as an important cause of morbidity and mortality in both solid organ and hematopoietic stem cell transplant recipients. Mortality rates due to PTLD and virus-induced HLH are reported to be quite high. We report a case of EBV-associated PTLD and HLH in a child after liver transplantation who was successfully managed due to timely intervention. This case highlights that measurement of EBV load by quantitative polymerase chain reaction assays is an important aid in the surveillance and diagnosis of PTLD and early detection of EBV-induced PTLD, and aggressive treatment with rituximab is a key to survival in patients who have undergone liver transplantation.
authors.affiliation: Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, Delhi NCR, India.
authors.forename: Bhawna
authors.initials: B
authors.lastname: Jha
authors.affiliation: Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, Delhi NCR, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Mohan
authors.affiliation: Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, Delhi NCR, India.
authors.forename: Smeeta
authors.initials: S
authors.lastname: Gajendra
authors.affiliation: Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, Delhi NCR, India.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Sachdev
authors.affiliation: Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, Delhi NCR, India.
authors.forename: Shalini
authors.initials: S
authors.lastname: Goel
authors.affiliation: Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, Delhi NCR, India.
authors.forename: Tushar
authors.initials: T
authors.lastname: Sahni
authors.affiliation: Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, Delhi NCR, India.
authors.forename: Vimarsh
authors.initials: V
authors.lastname: Raina
authors.affiliation: Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, Delhi NCR, India.
authors.forename: A
authors.initials: A
authors.lastname: Soin
mesh_terms: D002675:Child, Preschool; D057899:Cytophagocytosis; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D016031:Liver Transplantation; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D000069283:Rituximab / Q000627:therapeutic use
chemical_list: D007155:Immunologic Factors; D000069283:Rituximab
keywords: hemophagocytosis; liver transplant; post-transplant lymphoproliferative disease