title: Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome.
abstract: OBJECTIVE
  There is limited data on motor restlessness in Parkinson's disease (PD). Here we evaluate for clinical differences between cohorts of idiopathic Restless Legs Syndrome (iRLS), PD patients with leg restlessness, and PD with RLS.
  
  
  METHODS
  We examined 276 consecutive PD patients for leg restlessness symptoms, we compared clinical features of PD patients with RLS, PD patients with leg restlessness but not meeting RLS criteria, PD patient without RLS and iRLS.
  
  
  RESULTS
  A total of 262 PD patients who satisfied the inclusion criteria were analyzed. After excluding 23 possible secondary RLS or mimics, 28 were diagnosed with RLS and 18 with leg motor restlessness (LMR). Compared with iRLS patients, PD patients with RLS or LMR had older age of RLS/LMR onset, shorter duration of leg restlessness, less positive family history, different seasonal trends and more unilaterality of leg restlessness symptom (P<0.01) which were often in accordance with dominant Parkinsonism side and related with Parkinsonism severity. PD patients with RLS/LMR had lower daily dosage (P<0.01) and shorter duration (P<0.05) of dopaminergic medication when RLS/LMR symptom onset than PD without leg restlessness. PD with LMR had less severe Parkinsonism (P<0.05) and leg restlessness (P<0.01) symptoms than PD with RLS.
  
  
  CONCLUSIONS
  Clinical characteristics of PD patients with RLS and LMR were different from iRLS, differentiating these various subtypes can facilitate optimal treatment.
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.
authors.forename: Xiao-Jin
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Yang
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Neurology, University of Texas Health Science Center Houston, Houston, TX, USA.
authors.forename: William G
authors.initials: WG
authors.lastname: Ondo
authors.affiliation: Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Outram Road, Singapore.
authors.forename: Eng-King
authors.initials: EK
authors.lastname: Tan
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. Electronic address: yunchw@medmail.com.cn.
authors.forename: Yun-Cheng
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007866:Leg / Q000503:physiopathology*; D008297:Male; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D011595:Psychomotor Agitation / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D012148:Restless Legs Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology
keywords: Chinese; Clinical characteristics; Dopaminergic; Leg Motor Restlessness; Parkinson's disease; Restless Legs Syndrome