title: Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates.
abstract: Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, 12 healthy adult volunteers were recruited. With each subject, serum-PFAS concentrations were measured and their antibody responses prospectively followed for 30 days after a booster vaccination with diphtheria and tetanus. The results indicated that serum-PFAS concentrations were positively correlated and positively associated with age and male sex. The specific antibody concentrations in serum were increased from Day 4 to Day 10 post-booster, after which a constant concentration was reached. Serum PFAS concentrations showed significant negative associations with the rate of increase in the antibody responses. Interestingly, this effect was particularly strong for the longer-chain PFASs. All significant associations remained significant after adjustment for sex and age. Although the study involved a small number of subjects, these findings of a PFAS-associated reduction of the early humoral immune response to booster vaccination in healthy adults supported previous findings of PFAS immunosuppression in larger cohorts. Furthermore, the results suggested that cellular mechanisms right after antigen exposure should be investigated more closely to identify possible mechanisms of immunosuppression from PFAS.
authors.affiliation: a Institute for Inflammation Research, Department of Rheumatology .|b Department of Pediatrics and Adolescent Medicine , and.
authors.forename: Katrine
authors.initials: K
authors.lastname: Kielsen
authors.affiliation: a Institute for Inflammation Research, Department of Rheumatology .|b Department of Pediatrics and Adolescent Medicine , and.
authors.forename: Zaiba
authors.initials: Z
authors.lastname: Shamim
authors.affiliation: c Department of Clinical Immunology , Copenhagen University Hospital Rigshospitalet , Copenhagen , Denmark .
authors.forename: Lars P
authors.initials: LP
authors.lastname: Ryder
authors.affiliation: d Department of Environmental Medicine , University of Southern Denmark , Odense , Denmark .
authors.forename: Flemming
authors.initials: F
authors.lastname: Nielsen
authors.affiliation: d Department of Environmental Medicine , University of Southern Denmark , Odense , Denmark .|e Department of Environmental Health , Harvard Chan School of Public Health , Boston , MA , USA , and.
authors.forename: Philippe
authors.initials: P
authors.lastname: Grandjean
authors.affiliation: f Department of Biostatistics , School of Public Health, University of Copenhagen , Copenhagen , Denmark.
authors.forename: Esben
authors.initials: E
authors.lastname: Budtz-Jørgensen
authors.affiliation: a Institute for Inflammation Research, Department of Rheumatology .
authors.forename: Carsten
authors.initials: C
authors.lastname: Heilmann
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000917:Antibody Formation / Q000187:drug effects*; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000097:blood*; D007117:Immunization, Secondary; D008297:Male
chemical_list: D000907:Antibodies, Bacterial; D022422:Diphtheria-Tetanus Vaccine; D006845:Hydrocarbons, Fluorinated
keywords: Antibodies; immunotoxicity; perfluorinated alkylate substances; prospective study; vaccinations