title: Hepatocellular carcinoma associated with noncirrhotic autoimmune hepatitis.
abstract: A rare case of hepatocellular carcinoma (HCC) in a 78-year-old woman with a 10-year history of autoimmune hepatitis (AIH) without liver cirrhosis and no history of alcohol abuse, drug injection, or blood transfusion is presented. At the time HCC was diagnosed, based on imaging studies showing a 5-cm-diameter S6 liver tumor, she had normal liver function, positive anti-nuclear antibodies, negative hepatitis B and C markers, and elevated alfa-fetoprotein (AFP; 169 ng/ml) and protein-induced by vitamin K absence or antagonist II (PIVKA-II; 721 mAU/ml) levels. Following subsegmental S6 resection, no evidence of fibrosis or cirrhosis was observed.
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Chizu
authors.initials: C
authors.lastname: Maeda
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan. mstamano@dokkyomed.ac.jp.
authors.forename: Masaya
authors.initials: M
authors.lastname: Tamano
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Murohisa
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo Medical University, Tochigi, Japan.
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Yamagishi
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kojima
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Iijima
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sugaya
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nakano
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Akima
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo Medical University, Tochigi, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Tomita
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo Medical University, Tochigi, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimori
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hiraishi
keywords: Autoimmune hepatitis; Hepatocellular carcinoma; Non-liver-cirrhosis