title: A review of recent developments and applications of morphometry/stereology in lung research.
abstract: Design-based stereology is the gold standard of morphometry in lung research. Here, we analyze the current use of morphometric and stereological methods in lung research and provide an overview on recent methodological developments and biological observations made by the use of stereology. Based on this analysis we hope to provide useful recommendations for a good stereological practice to further the use of advanced and unbiased stereological methods.
authors.affiliation: Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany; and Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy), Hannover, Germany muehlfeld.christian@mh-hannover.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Mühlfeld
authors.affiliation: Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany; Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy), Hannover, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Hegermann
authors.affiliation: Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany; Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy), Hannover, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Wrede
authors.affiliation: Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany; and Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy), Hannover, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Ochs
mesh_terms: D000818:Animals; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000175:diagnosis*
keywords: design-based stereology; emphysema; fibrosis; morphometry; serial block face scanning electron microscopy