title: Organization of primary care pathway in head and neck oncology (short version): Organization of chemotherapy in head and neck oncology.
abstract: Chemotherapy may be indicated in head and neck cancer: as induction, associated with radiation therapy, or as a palliative solution, in case of local or locoregional progression if surgery and radiation therapy are contraindicated, and/or in case of metastatic progression. The most frequently used anticancer agents are platins, antimetabolites (5-fluorouracil, methotrexate) and taxanes. For several years now, in some indications, chemotherapy may be associated with targeted anti-EGFR antibody therapy. Prescription of chemotherapy and follow-up in head and neck cancer requires particular attention due to comorbidities related to alcohol abuse and smoking and frequent denutrition. Management thus requires close cooperation between the ENT physician, medical oncologists and radiation oncologists.
authors.affiliation: Pôle de cancérologie, clinique universitaire d'oncologie médicale, hôpital Michallon, CHU de Grenoble, 38043 Grenoble cedex 09, France. Electronic address: jpavillet@chu-grenoble.fr.
authors.forename: J
authors.initials: J
authors.lastname: Pavillet
authors.affiliation: Oncologie médicale, CLCC Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: J
authors.initials: J
authors.lastname: Guigay
authors.affiliation: Service d'ORL et de chirurgie cervico-faciale, CHU Paris Est, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Lacau Saint-Guily
authors.affiliation: Clinique universitaire d'ORL, hôpital Michallon, CHU de Grenoble, 38043 Grenoble cedex 09, France.
authors.forename: C-A
authors.initials: CA
authors.lastname: Righini
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003142:Communication; D019091:Critical Pathways; D003952:Diagnostic Imaging; D005602:France; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D059351:Organ Sparing Treatments; D010166:Palliative Care; D010348:Patient Care Team; D010808:Physical Examination; D011320:Primary Health Care; D018714:Radiotherapy, Adjuvant
chemical_list: D000970:Antineoplastic Agents
keywords: Care pathway; Chemotherapy; Head and neck; Targeted therapy