title: Self-immolative base-mediated conjugate release from triazolylmethylcarbamates.
abstract: A range of carbamate functionalized 1,4-disubstituted triazoles featuring a base sensitive trigger residue, plus a model aromatic amine reporter group, were prepared via copper(i) catalysed azide-alkyne cycloaddition and evaluated for their self-immolative characteristics. This study revealed a clear structure-reactivity relationship, via Hammett analysis, between the structure of the 1,4-disubstituted triazole and the rate of self-immolative release of the amine reporter group, thus demonstrating that under basic conditions this type of triazole derivative has the potential to be employed in a range of chemical release systems.
authors.affiliation: Department of Chemistry, University of Reading, Reading, Berkshire RG6 6AD, UK. a.t.russell@reading.ac.uk.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Blencowe
authors.forename: David W
authors.initials: DW
authors.lastname: Thornthwaite
authors.forename: Wayne
authors.initials: W
authors.lastname: Hayes
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Russell