title: High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis.
abstract: Ovarian cancer, the most lethal gynecological cancer, related closely to tumor stage. High-grade ovarian cancer always results in a late diagnose and high recurrence, which reduce survival within five years. Until recently, curable therapy is still under research and anti-angiogenesis proves a promising way. Tumor-derived exosomes are essential in tumor migration and metastases such as angiogenesis is enhanced by exosomes. In our study, we have made comparison between high-grade and unlikely high-grade serous ovarian cancer cells on exosomal function of endothelial cells proliferation, migration and tube formation. Exosomes derived from high-grade ovarian cancer have a profound impact on angiogenesis with comparison to unlikely high-grade ovarian cancer. Proteomic profiles revealed some potential proteins involved in exosomal function of angiogenesis such as ATF2, MTA1, ROCK1/2 and so on. Therefore, exosomes plays an influential role in angiogenesis in ovarian serous cancer and also function more effectively in high-grade ovarian cancer cells.
authors.affiliation: Fujian Maternity and Children Health Hospital Fujian Medical University Teaching Hospital Fuzhou 350005, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Yi
authors.affiliation: The Fifth People's Hospital of Shanghai, Fudan University Shanghai 200240, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Yang
authors.affiliation: The Fifth People's Hospital of Shanghai, Fudan University Shanghai 200240, China.
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Zhang
authors.affiliation: The Fifth People's Hospital of Shanghai, Fudan University Shanghai 200240, China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Chen
mesh_terms: D042501:Angiogenic Proteins / Q000378:metabolism*; D000077216:Carcinoma, Ovarian Epithelial; D002465:Cell Movement; D049109:Cell Proliferation; D048430:Cell Shape; D002470:Cell Survival; D002478:Cells, Cultured; D017077:Culture Media, Conditioned / Q000378:metabolism; D055354:Exosomes / Q000378:metabolism* / Q000473:pathology; D005260:Female; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D060787:Neoplasm Grading; D009375:Neoplasms, Glandular and Epithelial / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic; D010051:Ovarian Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D042501:Angiogenic Proteins; D017077:Culture Media, Conditioned
keywords: Ovarian cancerexosome; angiogenesis; proteomic profiles