title: Long-term Survival in a Patient with Metastatic Spinal Cord Compression from a Prostate Cancer with Ultra-high PSA: Case Report and Review of the Literature.
abstract: A 77-year-old man presented to the hospital for non-ambulation of 48 hours prior to admission.  He was found to have a metastatic spinal cord compression (MSCC), a PSA exceeding 27,000, and biopsy-confirmed prostate cancer. After palliative radiation (RT) to the spine and medical treatment, the patient recovered his functions fully and survived for more than 7.5 years, far beyond what would be expected based on current published literature.  A systematic review of the literature of MSCC in patients with prostate cancer was carried out. Prognostic factors of ambulation after RT included pre-treatment neurological status, duration of neurological deficits, and severity of the neurological impairment. Positive predictive factors of local control included single level of metastasis, time of development of motor deficits of more than 14 days, no prior androgen-deprivation therapy (ADT), age under 65, and longer course of RT (10 fractions of 2 Gy). Absence of prior ADT, pre-treatment ambulation, a single site of metastasis, and haemoglobin of less than 12g/L were positive predictors for survival.
authors.affiliation: Department of Radiation Oncology, Juravinski Cancer Centre-McMaster University.
authors.forename: Nhu Tram
authors.initials: NT
authors.lastname: Nguyen
authors.affiliation: Oncology, Division of Medical Oncology, Juravinski Cancer Centre-McMaster University.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Hotte
authors.affiliation: Oncology, Division of Radiation Oncology, Juravinski Cancer Centre-McMaster University.
authors.forename: Ian
authors.initials: I
authors.lastname: Dayes
keywords: case report; literature review; prostate cancer; spinal cord compression; ultra-high psa