title: Effects of a regular exercise program on biochemical parameters of type 2 diabetes mellitus patients.
abstract: BACKGROUND
  We aimed to investigate the effects of a regular exercise program on exercise capacity, blood biochemical profiles, certain antioxidant and oxidative stress parameters of type 2 Diabetes mellitus (DM) patients.
  
  
  METHODS
  Thirty one type 2 DM patients (ages ranging from 42-65 years) who have hemoglobin A1c (HbA1c) levels ≥7.5% and ≤9.5% were included to study and performed two cardiopulmonary exercise tests (CPET) before and after the exercise program. Subjects performed aerobic exercise training for 90 minutes a day; 3 days a week during 12 weeks. Blood samples were collected to analyze certain oxidant and antioxidant parameters (advanced oxidation protein products [AOPP], ferric reducing ability of plasma [FRAP], malondialdehyde [MDA], and sialic acid [SA]), blood lipid profile, fasting blood glucose (FBG) and HbA1c.
  
  
  RESULTS
  At the end of the program HbA1c and FBG, triglyceride (TG) and very-low-density lipoprotein (VLDL) levels decreased and high-density lipoprotein (HDL) increased significantly (P=0.000, P=0.001, P=0.008, P=0,001 and P=0.02, respectively). AOPP, FRAP, SA levels of the patients increased significantly following first CPET (P=0.000, P=0.049, P=0.014 respectively). At the end of the exercise program AOPP level increased significantly following last CPET. Baseline SA level increased significantly following exercise program (P=0.002).
  
  
  CONCLUSIONS
  We suggest that poor glycemic control which plays the major role in the pathogenesis of DM and its complications would be improved by 12 weeks of a regular exercise program. Whereas the acute exercise induces protein oxidation, regularly aerobic training may enhance the antioxidant status of type 2 DM patients.
authors.affiliation: Department of Sports Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey - dincersu@gmail.com.
authors.forename: Şensu
authors.initials: Ş
authors.lastname: Dinçer
authors.forename: Mehmet
authors.initials: M
authors.lastname: Altan
authors.forename: Duygu
authors.initials: D
authors.lastname: Terzioğlu
authors.forename: Ezel
authors.initials: E
authors.lastname: Uslu
authors.forename: Kubilay
authors.initials: K
authors.lastname: Karşidağ
authors.forename: Şule
authors.initials: Ş
authors.lastname: Batu
authors.forename: Gökhan
authors.initials: G
authors.lastname: Metin
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000628:therapy*; D005081:Exercise Therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids; D016877:Oxidants