title: Ectopic pregnancy rate increases with the number of retrieved oocytes in autologous in vitro fertilization with non-tubal infertility but not donor/recipient cycles: an analysis of 109,140 clinical pregnancies from the Society for Assisted Reproductive Technology registry.
abstract: OBJECTIVE
  To study the impact of controlled ovarian stimulation on ectopic pregnancy (EP) rate as a function of the number of oocytes retrieved, using donor IVF cycles as a control.
  
  
  METHODS
  Retrospective cohort study using a large national database.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Data from 109,140 cycles from the 2008-2010 SART registry, including 91,504 autologous cycles and 17,636 donor cycles in patients with non-tubal infertility.
  
  
  METHODS
  Varying amounts of oocytes retrieved in autologous and donor IVF.
  
  
  METHODS
  Ectopic pregnancy rates.
  
  
  RESULTS
  In autologous cycles, the EP rate significantly increased as oocyte yield increased. This association was not found in oocyte recipients.
  
  
  CONCLUSIONS
  In autologous IVF cycles, increasing oocyte yield is correlated with a significantly increased EP rate. This association is not found in oocyte recipients, indicating that the increased EP rate may be due to the supraphysiologic hormone levels achieved with controlled ovarian hyperstimulation.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University, Durham, North Carolina.
authors.forename: Kelly S
authors.initials: KS
authors.lastname: Acharya
authors.affiliation: Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina.
authors.forename: Chaitanya R
authors.initials: CR
authors.lastname: Acharya
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University, Durham, North Carolina.
authors.forename: Meredith P
authors.initials: MP
authors.lastname: Provost
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University, Durham, North Carolina.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Yeh
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University, Durham, North Carolina.
authors.forename: Ryan G
authors.initials: RG
authors.lastname: Steward
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University, Durham, North Carolina.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Eaton
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University, Durham, North Carolina. Electronic address: muashersj@gmail.com.
authors.forename: Suheil J
authors.initials: SJ
authors.lastname: Muasher
mesh_terms: D000328:Adult; D064592:Autografts; D004624:Embryo Transfer / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D018587:Oocyte Donation / Q000706:statistics & numerical data*; D054315:Oocyte Retrieval / Q000009:adverse effects / Q000706:statistics & numerical data*; D009865:Oocytes; D011247:Pregnancy; D018873:Pregnancy Rate; D011271:Pregnancy, Ectopic / Q000453:epidemiology*; D012042:Registries; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data
keywords: Ectopic pregnancy; IVF; autologous; donor; in vitro fertilization; oocytes