title: Long-Term Clinical Outcome after Treatment for High-Grade Cervical Lesions: A Retrospective Monoinstitutional Cohort Study.
abstract: BACKGROUND
  The aim of this retrospective observational study of women treated for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was to assess the long-term risk of residual/recurrent high-grade CIN.
  
  
  METHODS
  We evaluated 760 women treated by loop electrosurgical excision procedure (684) or conization (76) between 2000 and 2009, and followed up to June 30, 2014 (median follow-up 6.7 years, range 4-14). Visits every 6 months for the first year after treatment and yearly for up to the following 10 years included cytology, colposcopy when indicated, and HPV testing (search and typing).
  
  
  RESULTS
  CIN2+ or vaginal intraepithelial neoplasia grade 2 or worse (VAIN2+) was detected in 67 cases (8.8%), 39 at first follow-up and 28 after one/more negative visits. The risk of CIN2+ was higher in case of positive margins (odds ratio (OR) 8.04, 95% CI 4.31-15.0), type 3 transformation zone (OR for CIN3 27.7, 95% CI 2.07-36.9), CIN3+ excision (OR 6.02, 95% CI 1.73-20.9), and positive high-risk HPV test at first follow-up (OR for HPV16: 20.6, 95% CI 6.8-62.6; OR for other hrHPV types: 18.3, 95% CI 5.9-57.0).
  
  
  CONCLUSIONS
  Residual/recurrent high-grade CIN occurred in <9% cases, and the risk was associated with transformation zone type, lesion grade, margins status, and hrHPV test result at 6-12 months of follow-up.
authors.affiliation: Immunology and Molecular Oncology Unit, Veneto Institute of Oncology-(IOV-) IRCCS, Via Gattamelata 64, 35128 Padua, Italy.
authors.forename: Annarosa
authors.initials: A
authors.lastname: Del Mistro
authors.affiliation: Department of Woman and Child Health, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padua, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Matteucci
authors.affiliation: Department of Woman and Child Health, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padua, Italy.
authors.forename: Egle Alba
authors.initials: EA
authors.lastname: Insacco
authors.affiliation: Department of Pathology, Azienda Ospedaliera di Padova, Via Gabelli, 35121 Padua, Italy.
authors.forename: GianLibero
authors.initials: G
authors.lastname: Onnis
authors.affiliation: Veneto Tumour Registry, Passaggio Gaudenzio 1, 35131 Padua, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Da Re
authors.affiliation: Department of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Baboci
authors.affiliation: Veneto Tumour Registry, Passaggio Gaudenzio 1, 35131 Padua, Italy.
authors.forename: Manuel
authors.initials: M
authors.lastname: Zorzi
authors.affiliation: Department of Woman and Child Health, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padua, Italy.
authors.forename: Daria
authors.initials: D
authors.lastname: Minucci
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000473:pathology