title: Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity.
abstract: Doxorubicin is the mainstay of treatment for various haematological malignancies and solid tumours. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanism of doxorubicin-induced cardiotoxicity may involve various signalling pathways including free radical generation, peroxynitrite formation, calcium overloading, mitochondrial dysfunction and alteration in apoptosis and autophagy. Interestingly, the use of resveratrol in combination with doxorubicin has been reported to prevent cardiac toxicity as well as to exert a synergistic effect against tumour cells both in vivo and in vitro. Thus, the aim of this review is to summarize current knowledge and to elucidate the protective effect of resveratrol in doxorubicin-induced cardiotoxicity.
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.|Department of Cardiology, Shanghai Minhang Hospital, Fudan University, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Cardiology, Shanghai Minhang Hospital, Fudan University, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Cardiology, Shanghai Minhang Hospital, Fudan University, Shanghai, China.
authors.forename: Da-dong
authors.initials: DD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D066126:Cardiotoxicity / Q000188:drug therapy* / Q000473:pathology; D004317:Doxorubicin / Q000009:adverse effects*; D006801:Humans; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology; D000077185:Resveratrol; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D000094162:Phytoalexins
chemical_list: D002316:Cardiotonic Agents; D012717:Sesquiterpenes; D013267:Stilbenes; D004317:Doxorubicin; D000077185:Resveratrol; D000094162:Phytoalexins
keywords: ROS; apoptosis; autophagy; cardiotoxicity; doxorubicin; resveratrol