title: Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model.
abstract: BACKGROUND
  The deterioration of hemodynamics instantly endangers the patients' life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiopulmonary function is not yet fully understood.
  
  
  METHODS
  We have previously established a porcine polytrauma model including blunt chest trauma, penetrating abdominal trauma, and hemorrhagic shock. Therapeutic hypothermia (34°C) was induced for 3 hours. We documented cardiovascular parameters and basic respiratory parameters. Pigs were euthanized after 15.5 hours.
  
  
  RESULTS
  Our polytrauma porcine model displayed sufficient trauma impact. Resuscitation showed adequate restoration of hemodynamics. Induced hypothermia had neither harmful nor major positive effects on the animals' hemodynamics. Though heart rate significantly decreased and mixed venous oxygen saturation significantly increased during therapeutic hypothermia. Mean arterial blood pressure, central venous pressure, pulmonary arterial pressure, and wedge pressure showed no significant differences comparing normothermic trauma and hypothermic trauma pigs during hypothermia.
  
  
  CONCLUSIONS
  Induced hypothermia after polytrauma is feasible. No major harmful effects on hemodynamics were observed. Therapeutic hypothermia revealed hints for tissue protective impact. But the chosen length for therapeutic hypothermia was too short. Nevertheless, therapeutic hypothermia might be a useful tool for intensive care after polytrauma. Future studies should extend therapeutic hypothermia.
authors.affiliation: Department of Trauma Surgery, University of Schleswig-Holstein, 24105 Kiel, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Weuster
authors.affiliation: Department of Trauma Surgery, Hannover Medical School, 30625 Hannover, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Mommsen
authors.affiliation: Department of Trauma Surgery, University of Aachen, 52074 Aachen, Germany.
authors.forename: Roman
authors.initials: R
authors.lastname: Pfeifer
authors.affiliation: Department of Trauma Surgery, University of Marburg-Giessen, 35043 Marburg, Germany ; Department of Trauma Surgery, University of Magdeburg, 39120 Magdeburg, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Mohr
authors.affiliation: Department of Trauma Surgery, University of Marburg-Giessen, 35043 Marburg, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Ruchholtz
authors.affiliation: Department of Trauma Surgery, University of Düsseldorf, 40225 Düsseldorf, Germany.
authors.forename: Sascha
authors.initials: S
authors.lastname: Flohé
authors.affiliation: Department of Trauma Surgery, University of Aachen, 52074 Aachen, Germany ; Department of Trauma Surgery, University of Witten-Herdecke, 51109 Köln-Merheim, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Fröhlich
authors.affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, Austria.
authors.forename: Claudia
authors.initials: C
authors.lastname: Keibl
authors.affiliation: Department of Trauma Surgery, University of Schleswig-Holstein, 24105 Kiel, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Seekamp
authors.affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, Austria ; Department of Experimental Trauma Surgery, Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, Germany.
authors.forename: Martijn
authors.initials: M
authors.lastname: van Griensven
authors.affiliation: Department of Trauma Surgery, University of Düsseldorf, 40225 Düsseldorf, Germany.
authors.forename: Ingo
authors.initials: I
authors.lastname: Witte
mesh_terms: D000818:Animals; D001831:Body Temperature; D004195:Disease Models, Animal; D006439:Hemodynamics; D007036:Hypothermia, Induced; D008297:Male; D009104:Multiple Trauma / Q000503:physiopathology*; D013552:Swine