title: Ethnomedicinal survey of plants used in the treatment of malaria in Southern Nigeria.
abstract: BACKGROUND
  Malaria is one of the most severe public health problems worldwide. It is a leading cause of death and disease in many developing countries, where young children and pregnant women are the groups most affected. Spread of multidrug-resistant strains of Plasmodium and the adverse side effects of the existing anti-malarial drugs have necessitated the search for novel, well tolerated and more efficient antimalarial drugs. This ethnomedicinal study surveyed the different types of medicinal plants used for the treatment of malaria in Southern Nigeria with the intent of identifying plants that are traditionally employed in the treatment of malaria across geopolitical boundaries.
  
  
  METHODS
  Data were collected from 79 respondents composed of 50 traditional herbsellers and 29 herbal practitioners using a semi-structured questionnaire. Data was analyzed using frequency and percentages.
  
  
  RESULTS
  Of the 79 respondents interviewed, 24% were males while 76% were females. A total of 156 species belonging to 60 families were reported being used to treat malaria in the study area. Fabaceae was the most represented family having fourteen (14) plant species. Of the plants identified during the survey, Azadirachta indica was the species of highest relative frequency of citation (RFC - 1.0). The dominant plant parts used in the preparation of remedies were leaves (50.50%) and Decoction was the main method of preparation. Analysis of regional plant occurrence revealed that South-Western Nigeria represented the region with the highest plant occurrence (60.7%) followed by South-South (24%) and South-East (15.3%). Regional occurrence of plants used in the treatment of malaria in Southern Nigeria is reported here for the first time.
  
  
  CONCLUSIONS
  This study has documented a great diversity of plants used in the treatment of malaria in Southern Nigeria. Extracts prepared strictly according to the practitioners' recipes should therefore be screened for antiplasmodial activity and toxicity by in vitro and in vivo standard tests to justify their local usage. These studies might lead to the isolation and possible identification of potentially active compounds, which may be regarded as future promising phytomedicines in the treatment of malaria. Conservation of these plant species is also recommended to ensure their continuous availability for future use.
authors.affiliation: Department of Biology, College of Education, PMB 1251 Warri, Delta State, Nigeria. Electronic address: chipaz03@yahoo.com.
authors.forename: P C
authors.initials: PC
authors.lastname: Iyamah
authors.affiliation: Department of Plant Biology and Biotechnology, University of Benin, Benin City, Edo State, Nigeria.
authors.forename: M
authors.initials: M
authors.lastname: Idu
mesh_terms: D000328:Adult; D020834:Ethnopharmacology; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D016488:Medicine, African Traditional; D009549:Nigeria; D008517:Phytotherapy; D010946:Plants, Medicinal
keywords: Ethnomedicinal survey; Malaria; Medicinal plants; Regional occurrence; Relative frequency of citation; Southern Nigeria