title: A ring to rule them all: a cyclic ketene acetal comonomer controls the nitroxide-mediated polymerization of methacrylates and confers tunable degradability.
abstract: 2-Methylene-4-phenyl-1,3-dioxolane (MPDL) was successfully used as a controlling comonomer in NMP with oligo(ethylene glycol) methyl ether methacrylate (MeOEGMA) to prepare well-defined and degradable PEG-based P(MeOEGMA-co-MPDL) copolymers. The level of ester group incorporation is controlled, leading to reductions in molecular weight of up to 95% on hydrolysis. Neither the polymer nor its degradation products displayed cytoxicity. The method was also successfully applied to methyl methacrylate.
authors.affiliation: Institut Galien Paris-Sud, Université Paris-Sud, UMR CNRS 8612, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry cedex, France. julien.nicolas@u-psud.fr.
authors.forename: Vianney
authors.initials: V
authors.lastname: Delplace
authors.forename: Elise
authors.initials: E
authors.lastname: Guégain
authors.forename: Simon
authors.initials: S
authors.lastname: Harrisson
authors.forename: Didier
authors.initials: D
authors.lastname: Gigmes
authors.forename: Yohann
authors.initials: Y
authors.lastname: Guillaneuf
authors.forename: Julien
authors.initials: J
authors.lastname: Nicolas
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005030:Ethylenes / Q000737:chemistry*; D006868:Hydrolysis; D007659:Ketones / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D009589:Nitrogen Oxides / Q000737:chemistry*; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005030:Ethylenes; D007659:Ketones; D008689:Methacrylates; D009589:Nitrogen Oxides; D011109:Polymethacrylic Acids; C008384:methacrylic acid; C030613:polymethacrylic acid; C039900:nitroxyl; C008223:ketene