title: The effects of fermented wheat powder (Lisosan G) on the blood lipids and oxidative status of healthy rabbits.
abstract: A number of studies have shown that whole grain products have strong antioxidant effects. Lisosan G, a powder produced from the fermentation of Triticum aestivum, has shown hepatoprotective effects. The aim of this paper was to evaluate the effects of Lisosan G on the serum lipid profile and oxidative status of healthy rabbits. Forty rabbits were fed either a normal diet or a diet containing 10 g, 20 g or 30 g Lisosan G/kg of feed for 60 days. The supplementation of Lisosan G did not cause any alteration of the aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin or creatinine concentrations, but caused a reduction in triglycerides, in low density lipoprotein (LDL) cholesterol, and an increase in high density lipoprotein (HDL) cholesterol. The antioxidant activity of Lisosan G has been confirmed on the basis of the reduction in the blood reactive oxygen metabolites (ROMs) and in the level of the thiobarbituric acid reactive substances (TBARS) together with increased vitamin A and E concentrations in the blood. Moreover, Lisosan G also caused the induction of antioxidant enzymes in the liver and kidney of the treated rabbits. This study has shown the ability of Lisosan G to improve the lipid profile and antioxidant status of the blood in healthy rabbits.
authors.affiliation: Institute of Agricultural Biology and Biotechnology, CNR, Via Moruzzi 2, 56100 Pisa, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Pozzo
authors.affiliation: Department of Agricultural, Environmental and Food Sciences, University of Molise, Via De Sanctis snc, 86100 Campobasso, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Vizzarri
authors.affiliation: Institute of Agricultural Biology and Biotechnology, CNR, Via Moruzzi 2, 56100 Pisa, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Ciardi
authors.affiliation: Department of Agricultural, Environmental and Food Sciences, University of Molise, Via De Sanctis snc, 86100 Campobasso, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Nardoia
authors.affiliation: Department of Agricultural, Environmental and Food Sciences, University of Molise, Via De Sanctis snc, 86100 Campobasso, Italy.
authors.forename: Marisa
authors.initials: M
authors.lastname: Palazzo
authors.affiliation: Department of Agricultural, Environmental and Food Sciences, University of Molise, Via De Sanctis snc, 86100 Campobasso, Italy.
authors.forename: Donato
authors.initials: D
authors.lastname: Casamassima
authors.affiliation: Institute of Agricultural Biology and Biotechnology, CNR, Via Moruzzi 2, 56100 Pisa, Italy. Electronic address: v.longo@ibba.cnr.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Longo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D003433:Crosses, Genetic; D019587:Dietary Supplements / Q000009:adverse effects; D005285:Fermentation; D006949:Hyperlipidemias / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D007778:Lactobacillus / Q000378:metabolism; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D010088:Oxidoreductases / Q000737:chemistry / Q000378:metabolism; D028321:Plant Preparations / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011817:Rabbits; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D014908:Triticum / Q000737:chemistry; D014886:Weaning; D000067348:Whole Grains / Q000737:chemistry; D015003:Yeasts / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D000960:Hypolipidemic Agents; D008055:Lipids; C522933:Lisosan G; D028321:Plant Preparations; D017382:Reactive Oxygen Species; D010088:Oxidoreductases
keywords: Antioxidant response; CVD biomarkers; Lisosan G; Oxidative status