title: Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats.
abstract: Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy remains to be clarified, oxidative stress and mitochondrial dysfunction play a crucial role in the pathogenesis of chronic diabetic complications. Taking this into consideration, the aim of this work was to evaluate the effects of 90-day avocado oil intake in brain mitochondrial function and oxidative status in streptozotocin-induced diabetic rats (STZ rats). Avocado oil improves brain mitochondrial function in diabetic rats preventing impairment of mitochondrial respiration and mitochondrial membrane potential (ΔΨ m ), besides increasing complex III activity. Avocado oil also decreased ROS levels and lipid peroxidation and improved the GSH/GSSG ratio as well. These results demonstrate that avocado oil supplementation prevents brain mitochondrial dysfunction induced by diabetes in association with decreased oxidative stress.
authors.affiliation: Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, MICH, Mexico.
authors.forename: Omar
authors.initials: O
authors.lastname: Ortiz-Avila
authors.affiliation: Facultad de Químico Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, 58240 Morelia, MICH, Mexico.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Esquivel-Martínez
authors.affiliation: Facultad de Químico Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, 58240 Morelia, MICH, Mexico.
authors.forename: Berenice Eridani
authors.initials: BE
authors.lastname: Olmos-Orizaba
authors.affiliation: Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, MICH, Mexico.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Saavedra-Molina
authors.affiliation: Facultad de Ciencias Médicas y Biológicas "Dr. Ignacio Chávez", Universidad Michoacana de San Nicolás de Hidalgo, 58020 Morelia, MICH, Mexico.
authors.forename: Alain R
authors.initials: AR
authors.lastname: Rodriguez-Orozco
authors.affiliation: Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, MICH, Mexico.
authors.forename: Christian
authors.initials: C
authors.lastname: Cortés-Rojo
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000517:prevention & control; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D014450:Electron Transport Complex III / Q000378:metabolism; D055951:Functional Food; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D053078:Membrane Potential, Mitochondrial; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000201:enzymology / Q000378:metabolism; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D018384:Oxidative Stress; D027421:Persea / Q000737:chemistry*; D010938:Plant Oils / Q000627:therapeutic use*; D011897:Random Allocation; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D004042:Dietary Fats, Unsaturated; D009419:Nerve Tissue Proteins; D010938:Plant Oils; D017382:Reactive Oxygen Species; D014450:Electron Transport Complex III; D005978:Glutathione