title: [Cholangitis with granulocytic epithelial lesion: a new entity with a specific treatment].
abstract: Herein, we report a case of cholangitis with granulocytic epithelial lesion associated with pancreatitis in a 22-year-old patient. The association of bile duct lesions and pancreatitis is usually very suggestive of IgG4 related disease. However, in our case, we found no IgG4 tissue infiltration and we found a granulocytic epithelial on the liver biopsy. Recently, cholangitis with granulocytic epithelial lesion was described in the literature. This entity is identified in 2 % of patients with sclerosing cholangitis. Patients are more likely children or young adults and often have an associated inflammatory bowel disease or rarely a pancreatitis. It is defined by the presence of neutrophilic bile duct lesions on a liver biopsy. Although rare, the diagnosis of cholangitis with granulocytic epithelial lesion is important because of its excellent response to immunosuppressive treatment.
authors.affiliation: Service d'anatomie et cytologie pathologiques, hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France. Electronic address: calvojessica@yahoo.fr.
authors.forename: Jessica
authors.initials: J
authors.lastname: Calvo
authors.affiliation: Service de gastro-entérologie, centre hospitalier de Gonesse, 25, rue Bernard-Février, 95500 Gonesse, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Dhalluin-Venier
authors.affiliation: Service d'imagerie médicale, hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France; UPMC, université Paris 06, 75005 Paris, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Arrivé
authors.affiliation: Service d'hépatologie, hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Corpechot
authors.affiliation: Service d'anatomie et cytologie pathologiques, hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France; UPMC, université Paris 06, 75005 Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Wendum
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D015415:Biomarkers; D002761:Cholangitis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D001651:Cholestasis, Extrahepatic / Q000209:etiology; D003092:Colitis / Q000188:drug therapy / Q000473:pathology; D003137:Common Bile Duct Diseases / Q000473:pathology; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D006098:Granulocytes / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D050500:Pancreatitis, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents
keywords: Auto-immune pancreatitis; Cholangite; Cholangitis; Granulocytic epithelial lesion; IgG4; Lésion épithéliale granulocytique; Pancréatite auto-immune