title: Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw.
abstract: Liver transplantation is a well-established treatment of patients with end-stage liver disease and selected liver tumors. Remarkable progress has been made over the last years concerning nearly all of its aspects. The aim of this study was to evaluate the evolution of long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery (Medical University of Warsaw).
  
  
  METHODS
  Data of 1500 liver transplantations performed between 1989 and 2014 were retrospectively analyzed. Transplantations were divided into 3 groups: group 1 including first 500 operations, group 2 including subsequent 500, and group 3 comprising the most recent 500. Five year overall and graft survival were set as outcome measures.
  
  
  RESULTS
  Increased number of transplantations performed at the site was associated with increased age of the recipients (p<0.001) and donors (p<0.001), increased rate of male recipients (p<0.001), and increased rate of piggyback operations (p<0.001), and decreased MELD (p<0.001), as well as decreased blood (p=0.006) and plasma (p<0.001) transfusions. Overall survival was 71.6% at 5 years in group 1, 74.5% at 5 years in group 2, and 85% at 2.9 years in group 3 (p=0.008). Improvement of overall survival was particularly observed for primary transplantations (p=0.004). Increased graft survival rates did not reach the level of significance (p=0.136).
  
  
  CONCLUSIONS
  Long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery are comparable to those achieved in the largest transplant centers worldwide and are continuously improving despite increasing recipient age and wider utilization of organs procured from older donors.
authors.forename: Marek
authors.initials: M
authors.lastname: Krawczyk
authors.forename: Michał
authors.initials: M
authors.lastname: Grąt
authors.forename: Karolina
authors.initials: K
authors.lastname: Grąt
authors.forename: Karolina
authors.initials: K
authors.lastname: Wronka
authors.forename: Maciej
authors.initials: M
authors.lastname: Krasnodębski
authors.forename: Jan
authors.initials: J
authors.lastname: Stypułkowski
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Masior
authors.forename: Wacław
authors.initials: W
authors.lastname: Hołówko
authors.forename: Joanna
authors.initials: J
authors.lastname: Ligocka
authors.forename: Paweł
authors.initials: P
authors.lastname: Nyckowski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Wróblewski
authors.forename: Rafał
authors.initials: R
authors.lastname: Paluszkiewicz
authors.forename: Waldemar
authors.initials: W
authors.lastname: Patkowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zieniewicz
authors.forename: Leszek
authors.initials: L
authors.lastname: Pączek
authors.forename: Piotr
authors.initials: P
authors.lastname: Milkiewicz
authors.forename: Urszula
authors.initials: U
authors.lastname: Ołdakowska-Jedynak
authors.forename: Bogusław
authors.initials: B
authors.lastname: Najnigier
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Dudek
authors.forename: Piotr
authors.initials: P
authors.lastname: Remiszewski
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Grzelak
authors.forename: Oskar
authors.initials: O
authors.lastname: Kornasiewicz
authors.forename: Marcin
authors.initials: M
authors.lastname: Kotulski
authors.forename: Piotr
authors.initials: P
authors.lastname: Smoter
authors.forename: Mariusz
authors.initials: M
authors.lastname: Grodzicki
authors.forename: Michał
authors.initials: M
authors.lastname: Korba
authors.forename: Piotr
authors.initials: P
authors.lastname: Kalinowski
authors.forename: Michał
authors.initials: M
authors.lastname: Skalski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zając
authors.forename: Rafał
authors.initials: R
authors.lastname: Stankiewicz
authors.forename: Marta
authors.initials: M
authors.lastname: Przybysz
authors.forename: Bartosz
authors.initials: B
authors.lastname: Cieślak
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Nazarewski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Nowosad
authors.forename: Konrad
authors.initials: K
authors.lastname: Kobryń
authors.forename: Michał
authors.initials: M
authors.lastname: Wasilewicz
authors.forename: Joanna
authors.initials: J
authors.lastname: Raszeja-Wyszomirska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Piwowarska
authors.forename: Dorota
authors.initials: D
authors.lastname: Giercuszkiewicz
authors.forename: Joanna
authors.initials: J
authors.lastname: Sańko-Resmer
authors.forename: Sławomir
authors.initials: S
authors.lastname: Rejowski
authors.forename: Monika
authors.initials: M
authors.lastname: Szydłowska-Jakimiuk
authors.forename: Barbara
authors.initials: B
authors.lastname: Górnicka
authors.forename: Bogna
authors.initials: B
authors.lastname: Wróblewska-Ziarkiewicz
authors.forename: Michał
authors.initials: M
authors.lastname: Mazurkiewicz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Niewiński
authors.forename: Jacek
authors.initials: J
authors.lastname: Pawlak
authors.forename: Ryszard
authors.initials: R
authors.lastname: Pacho
mesh_terms: D046148:Donor Selection; D058625:End Stage Liver Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011044:Poland; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D015996:Survival Rate; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome