title: Review of Results of QuantiFERON TB Gold Test in Presumed Ocular Tuberculosis in a South Indian Patient Population.
abstract: OBJECTIVE
  To review the results of QuantiFERON TB gold (QFT-G) in our patient population of presumed ocular tuberculosis and the effect of antitubercular therapy (ATT) on the QFT-G result.
  
  
  METHODS
  Retrospective review of 82 cases of presumed ocular tuberculosis with a successful response to ATT and 6 months follow-up post-ATT. Appropriate statistical analysis was done for associations between QFT-G and independent variables. Pre-ATT QFT-G values were also compared to the post-ATT value.
  
  
  RESULTS
  There were no statistically significant differences in the results of QFT-G with age (0.635), gender (0.096), history of oral steroids (0.171), or type of uveitis (0.664). There was a statistically significant association between a positive QFT-G and serpiginous-like choroiditis (0.048). The majority of our patients had positive QFT even after completion of ATT but with a significant drop in the mean values post ATT (0.010).
  
  
  CONCLUSIONS
  Our study shows significant association of positive QFT with serpiginous-like choroiditis and persistent positivity even after completion of ATT in majority of cases in our population. There was, however, a drop in the mean values of QFT-G post-ATT.
authors.affiliation: a Vittala International Institute of Ophthalmology & Prabha Eye Clinic and Research Center , Bangalore , India and.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Babu
authors.affiliation: a Vittala International Institute of Ophthalmology & Prabha Eye Clinic and Research Center , Bangalore , India and.
authors.forename: Soumya S
authors.initials: SS
authors.lastname: Bhat
authors.affiliation: b Department of Biostatistics , NIMHANS , Bangalore , India.
authors.forename: Mariamma
authors.initials: M
authors.lastname: Philips
authors.affiliation: b Department of Biostatistics , NIMHANS , Bangalore , India.
authors.forename: D K
authors.initials: DK
authors.lastname: Subbakrishna
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial; D000995:Antitubercular Agents / Q000627:therapeutic use; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007194:India; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012189:Retrospective Studies; D014374:Tuberculin Test; D014392:Tuberculosis, Ocular / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000942:Antigens, Bacterial; D000995:Antitubercular Agents; C072681:Mycobacterium tuberculosis antigens; D007371:Interferon-gamma
keywords: Antitubercular therapy; latent tuberculosis; ocular tuberculosis; quantiferon TB test; uveitis