title: Autophagy in alcoholic liver disease, self-eating triggered by drinking.
abstract: Macroautophagy (autophagy) is an evolutionarily conserved mechanism. It is important for normal cellular function and also plays critical roles in the etiology and pathogenesis of a number of human diseases. In alcohol-induced liver disease, autophagy is a protective mechanism against the liver injury caused by alcohol. Autophagy is activated in acute ethanol treatment but could be suppressed in chronic and/or high dose treatment of alcohol. The selective removal of lipid droplets and/or damaged mitochondria is likely the major mode of autophagy in reducing liver injury. Understanding the dynamics of the autophagy process and the approach to modulate autophagy could help finding new ways to battle against alcohol-induced liver injury.
authors.affiliation: Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA; College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018 Shandong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA.
authors.forename: Bilon
authors.initials: B
authors.lastname: Khambu
authors.affiliation: Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA. Electronic address: xmyin@iu.edu.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Yin
mesh_terms: D001343:Autophagy; D002492:Central Nervous System Depressants / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D000431:Ethanol / Q000009:adverse effects; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008108:Liver Diseases, Alcoholic / Q000473:pathology*; D008930:Mitochondria, Liver / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol