title: Accelerated atherosclerosis in patients with common variable immunodeficiency: Is it overlooked or absent?
abstract: Common variable immunodeficiency (CVID) is a heterogeneous primary deficiency characterized by hypogammaglobulinemia, recurrent infections, and an increased risk of autoimmune disease and malignancy, and so chronic inflammation. Cardiovascular disease is the leading cause of mortality in the general population. Recent studies have suggested that chronic inflammation is an important player in the pathogenesis of CVID. Accelerated atherosclerosis due to ongoing inflammation from recurrent infections and autoimmunity is an expected clinical entity in patients with CVID. However, cardiovascular mortality as a cause of death in CVID series is either absent or minor. We hypothesized that accelerated atherosclerosis and cardiovascular disease are overlooked by clinicians, or atherosclerosis is really lower than that in the general population that may be prevented by some factors such as life-long immunoglobulin replacement treatment.
authors.affiliation: Necmettin Erbakan University, Meram Faculty of Medicine, Department of Clinical Immunology and Allergy, Konya, Turkey. Electronic address: mdramazan@gmail.com.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Ucar
authors.affiliation: Necmettin Erbakan University, Meram Faculty of Medicine, Department of Clinical Immunology and Allergy, Konya, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Necmettin Erbakan University, Meram Faculty of Medicine, Department of Nephrology, Konya, Turkey.
authors.forename: Kultigin
authors.initials: K
authors.lastname: Turkmen
authors.affiliation: Necmettin Erbakan University, Meram Faculty of Medicine, Department of Clinical Immunology and Allergy, Konya, Turkey.
authors.forename: Ahmet Zafer
authors.initials: AZ
authors.lastname: Calıskaner
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000150:complications* / Q000276:immunology / Q000503:physiopathology*; D015551:Autoimmunity / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000276:immunology / Q000503:physiopathology*; D015897:Comorbidity; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000378:metabolism; D007249:Inflammation; D008297:Male; D008962:Models, Theoretical; D012307:Risk Factors
chemical_list: D016207:Cytokines; D007136:Immunoglobulins