title: Reversal of severe lactic acidosis with thiamine in a renal allograft recipient.
abstract: A 48-year-old female patient with end-stage renal failure developed unexplained severe lactic acidosis (LA) associated with hyperglycemia during robotic-assisted laparoscopic renal transplantation. Initial treatment with sodium bicarbonate and insulin infusion were ineffective in treating acidemia. Postoperatively, intravenous administration of thiamine resulted in rapid improvement of LA and blood sugar levels. Uremia and chronic hemodialysis might be the causes behind the quantitative/qualitative deficiency of thiamine unmasked during the surgical stress. Though a rare entity, acute thiamine deficiency should be considered in the differential diagnosis of unexplained severe LA in patients with chronic kidney disease and hemodialysis who undergo major surgery or admitted to critical illness care units.
authors.affiliation: Department of Anaesthesia and Critical Care, Smt. K. M. Mehta and Smt. G.R. Doshi Institute of Kidney Diseases and Research Center, Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India.
authors.forename: K Nanda
authors.initials: KN
authors.lastname: Kumar
authors.affiliation: Department of Anaesthesia and Critical Care, Smt. K. M. Mehta and Smt. G.R. Doshi Institute of Kidney Diseases and Research Center, Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India.
authors.forename: Veena R
authors.initials: VR
authors.lastname: Shah
authors.affiliation: Department of Anaesthesia and Critical Care, Smt. K. M. Mehta and Smt. G.R. Doshi Institute of Kidney Diseases and Research Center, Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India.
authors.forename: Beena K
authors.initials: BK
authors.lastname: Parikh
authors.affiliation: Department of Anaesthesia and Critical Care, Smt. K. M. Mehta and Smt. G.R. Doshi Institute of Kidney Diseases and Research Center, Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India.
authors.forename: Sumedha
authors.initials: S
authors.lastname: Sonde
keywords: chronic hemodialysis; lactic acidosis; renal transplantation; thiamine deficiency