title: PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent.
abstract: We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [(18)F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.
authors.affiliation: †Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Nielsen
authors.affiliation: †Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
authors.forename: Christian R
authors.initials: CR
authors.lastname: Ugaz
authors.affiliation: ‡Department of Imaging Research, Merck Research Laboratories, West Point, Pennsylvania 19486, United States.
authors.forename: Wenping
authors.initials: W
authors.lastname: Li
authors.affiliation: †Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
authors.forename: Abigail G
authors.initials: AG
authors.lastname: Doyle
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D054879:Halogenation; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000438:Alcohols; D006845:Hydrocarbons, Fluorinated; D011725:Pyridines; D013450:Sulfones