title: Hyperreactive Malarial Splenomegaly Syndrome--Can the Diagnostic Criteria Be Improved?
abstract: Hyperreactive Malarial Splenomegaly Syndrome (HMSS) was described and defined before sensitive tests for malaria were available. We present a series of seven individuals who were referred to our clinics with possible HMSS. Chronic malaria was demonstrated in those successfully treated but not in those who failed to respond to therapy. This observation suggests that the newer molecular malaria assays have a role to play in the identification of individuals who are likely to respond to treatment for HMSS in non-endemic regions.
authors.affiliation: Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, London, United Kingdom alastairmcgregor@yahoo.co.uk.
authors.forename: Alastair
authors.initials: A
authors.lastname: McGregor
authors.affiliation: Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Tom
authors.initials: T
authors.lastname: Doherty
authors.affiliation: Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Patricia
authors.initials: P
authors.lastname: Lowe
authors.affiliation: Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Chiodini
authors.affiliation: Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: William
authors.initials: W
authors.lastname: Newsholme
mesh_terms: D000293:Adolescent; D000328:Adult; D000354:Africa, Western; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008288:Malaria / Q000150:complications* / Q000175:diagnosis; D016778:Malaria, Falciparum / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D013163:Splenomegaly / Q000175:diagnosis* / Q000209:etiology / Q000469:parasitology; D055815:Young Adult