title: [Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus].
abstract: Fractions of aqueous and water-alcohol extracts of the birch fungus Inonotus obliquus have antiviral effect against the human immunodeficiency virus type 1 (HIV-1). Antiviral properties of low toxic extracts were manifested in the concentration of 5.0 μg/ml upon simultaneous application with the virus in the lymphoblastoid cells culture MT-4. The extract of the birch fungus can be used for development of new antiviral drugs, inhibitors of HIV-replication when used both in the form of individual drugs and as a part of complex therapy.
authors.forename: V A
authors.initials: VA
authors.lastname: Shibnev
authors.forename: T M
authors.initials: TM
authors.lastname: Garaev
authors.forename: M P
authors.initials: MP
authors.lastname: Finogenova
authors.forename: L B
authors.initials: LB
authors.lastname: Kalnina
authors.forename: D N
authors.initials: DN
authors.lastname: Nosik
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D045424:Complex Mixtures / Q000737:chemistry / Q000494:pharmacology*; D000431:Ethanol / Q000737:chemistry; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D014779:Virus Replication / Q000187:drug effects*; D014867:Water / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D045424:Complex Mixtures; D014867:Water; D000431:Ethanol