title: Urologic applications of botulinum toxin.
abstract: The neuromuscular blocker botulinum toxin has a wide variety of medical applications, including overactive bladder and neurogenic detrusor overactivity in patients in whom drug therapy fails or is not well tolerated. Botulinum toxin therapy for these conditions has been shown to be safe and effective in several large multicenter randomized controlled trials. Off-label uses in urology include detrusor external sphincter dyssynergia and pelvic pain syndromes.
authors.affiliation: Female Pelvic Medicine and Reconstructive Surgery, Glickman Urological Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: King
authors.affiliation: Female Pelvic Medicine and Reconstructive Surgery, Glickman Urological Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Quirouet
authors.affiliation: Female Pelvic Medicine and Reconstructive Surgery, Glickman Urological Institute, Cleveland Clinic, Cleveland, OH, USA.|Fellowship Director, Female Pelvic Medicine and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH, USA. E-mail: moorec6@ccf.org.|Assistant Professor of Urology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Courtenay K
authors.initials: CK
authors.lastname: Moore
mesh_terms: D001905:Botulinum Toxins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D001905:Botulinum Toxins