title: More heritability probably captured by psoriasis genome-wide association study in Han Chinese.
abstract: Missing heritability is a common problem in genome-wide association studies in complex diseases/traits. To quantify the unbiased heritability estimate, we applied the phenotype correlation-genotype correlation regression in psoriasis genome-wide association data in Han Chinese which comprises 1139 cases and 1132 controls. We estimated that 45.7% heritability of psoriasis in Han Chinese were captured by common variants (s.e.=12.5%), which reinforced that the majority of psoriasis heritability can be covered by common variants in genome-wide association data (68.2%). The results provided evidence that the heritability covered by psoriasis genome-wide genotyping data was probably underestimated in previous restricted maximum likelihood method. Our study highlights the broad role of common variants in the etiology of psoriasis and sheds light on the possibility to identify more common variants of small effect by increasing the sample size in psoriasis genome-wide association studies.
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China.
authors.forename: Long
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China.
authors.forename: Changbing
authors.initials: C
authors.lastname: Shen
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China.
authors.forename: Caihong
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China. Electronic address: yangsen@medmail.com.cn.
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China; Department of Genetics and Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, United States; Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517 United States. Electronic address: xianyongyin@gmail.com.
authors.forename: Xianyong
authors.initials: X
authors.lastname: Yin
authors.affiliation: Institute of Dermatology, Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, Anhui 230032, China; Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei City, Anhui 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei City, Anhui 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei City, Anhui 230032, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002681:China; D005006:Ethnicity / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D016013:Likelihood Functions; D011565:Psoriasis / Q000235:genetics*
keywords: Genome-wide association; Missing heritability; Phenotype correlation–genotype correlation; Psoriasis