title: Comparison of the short-term efficacy of sequential treatment with intravesical single-port laparoscopic partial cystectomy with bladder preservation or open partial cystectomy in combination with cisplatin plus gemcitabine chemotherapy.
abstract: This study aimed to assess the short-term efficacy of sequential therapy for T2/T3a bladder cancer with intravesical single-port laparoscopic partial cystectomy or open partial cystectomy combined with cisplatin plus gemcitabine (GC) chemotherapy in a prospective randomized controlled study. Thirty patients with bladder cancer who underwent open partial cystectomy (group A) or single-port laparoscopic partial cystectomy (group B) and received standard GC chemotherapy were analyzed. Perioperative functional indicators and tumor recurrence during a 1-year postoperative follow-up were compared between the two groups. The baseline characteristics were comparable between the two groups. The mean operative time, amount of blood loss and duration of hospital stay were 90.3 min, 182.0 ml and 7.3 days, respectively, for group A, and 105.3 min, 49.3 ml and 5.8 days, respectively, for group B. No secondary postoperative bleeding, urine leakage, wound infection or other complications were observed in the two groups. Postoperative scarring was not evident in group B. The overall incidence of surgical complications, tumor recurrence rate and complications during chemotherapy in the postoperative follow-up period of 12 months were similar between the two groups. Single-port laparoscopic partial cystectomy surgery is an idea surgical method for the treatment of invasive bladder cancer, with good surgical effect, minimal invasiveness, rapid recovery and short hospital stay. The data from 1-year postoperative follow-up showed that laparoscopic surgery was superior with regard to perioperative bleeding, postoperative recovery and duration of indwelling urinary catheter use. However, regarding the tumor recurrence rate, long-term comparative details are required to determine the effect of laparoscopic surgery.
authors.affiliation: Chinese People's Liberation Army General Hospital & Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China ; Department of Urology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, P.R. China.
authors.forename: Hai-Xing
authors.initials: HX
authors.lastname: Mai
authors.affiliation: Department of Urology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, P.R. China.
authors.forename: Jun-LE
authors.initials: JL
authors.lastname: Liu
authors.affiliation: Department of Urology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, P.R. China.
authors.forename: Shu-Jun
authors.initials: SJ
authors.lastname: Pei
authors.affiliation: Chinese People's Liberation Army General Hospital & Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China.
authors.forename: L I
authors.initials: LI
authors.lastname: Zhao
authors.affiliation: Chinese People's Liberation Army General Hospital & Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Qu
authors.affiliation: Chinese People's Liberation Army General Hospital & Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China.
authors.forename: Jin-Kai
authors.initials: JK
authors.lastname: Dong
authors.affiliation: Chinese People's Liberation Army General Hospital & Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China.
authors.forename: Biao
authors.initials: B
authors.lastname: Chen
authors.affiliation: Chinese People's Liberation Army General Hospital & Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China.
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Chinese People's Liberation Army General Hospital & Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Urology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, P.R. China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Chen
keywords: bladder cancer; cystectomy; laparoscopy; single-port laparoscopy