title: Non-alcoholic fatty liver disease resolution following sleeve gastrectomy.
abstract: BACKGROUND
  Non-alcoholic fatty liver disease (NAFLD), a disease highly prevalent among the morbidly obese population, is one of the most common causes of chronic liver disease today. The purpose of this study was to observe the effect of laparoscopic sleeve gastrectomy (LSG) on the resolution of NAFLD.
  
  
  METHODS
  A retrospective study was conducted of 84 patients diagnosed with NAFLD prior to undergoing LSG. The diagnosis of NAFLD was achieved based on transabdominal ultrasonographic imaging as per the 2012 joint guidelines for the diagnosis of NAFLD (American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology). The patients had follow-up anthropometric measurements and were re-evaluated with postoperative ultrasounds at different time frames to assess the resolution of the disease.
  
  
  RESULTS
  The median age of the patients was 44 (17-62), and 66.7 % were female. Average time since surgery was 3.3 years (range 1-5 years). The mean pre- and postoperative BMIs were 46.6 ± 7.8 and 33.0 ± 7.1, respectively, with a mean percent excess weight loss (%EWL) of 55.7 % ± 23.0. A total of 47 (56 %) patients showed complete resolution of NAFLD postoperatively. Multivariate analysis showed a significant resolution of NAFLD in patients achieving >50 % EWL (OR 10.1; p < 0.001) after controlling for age and sex.
  
  
  CONCLUSIONS
  Weight loss after LSG effectively resolved NAFLD in more than half of the obese patients in this study and can prove to be a useful tool in tackling the disease in the future.
authors.affiliation: Department of Surgery, Amiri Hospital, Kuwait Ministry of Health, Kuwait, Kuwait.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Algooneh
authors.affiliation: Department of Surgery, Amiri Hospital, Kuwait Ministry of Health, Kuwait, Kuwait.
authors.forename: Sulaiman
authors.initials: S
authors.lastname: Almazeedi
authors.affiliation: Department of Surgery, Amiri Hospital, Kuwait Ministry of Health, Kuwait, Kuwait. salman.k.alsabah@gmail.com.
authors.forename: Salman
authors.initials: S
authors.lastname: Al-Sabah
authors.affiliation: Department of Radiology, Amiri Hospital, Kuwait Ministry of Health, Kuwait, Kuwait.
authors.forename: Maha
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: Department of Surgery, Amiri Hospital, Kuwait Ministry of Health, Kuwait, Kuwait.
authors.forename: Feras
authors.initials: F
authors.lastname: Othman
mesh_terms: D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000000981:diagnostic imaging*; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D011184:Postoperative Period; D012189:Retrospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography; D015431:Weight Loss; D055815:Young Adult
keywords: Bariatric; Metabolic surgery; NAFLD; Obesity; Sleeve gastrectomy