title: Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols.
abstract: The "green" reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac)3, triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced.
authors.affiliation: Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a, 18059 Rostock (Germany) http://www.catalysis.de.
authors.forename: Xinjiang
authors.initials: X
authors.lastname: Cui
authors.affiliation: Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a, 18059 Rostock (Germany) http://www.catalysis.de.
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Li
authors.affiliation: Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a, 18059 Rostock (Germany) http://www.catalysis.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Topf
authors.affiliation: Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a, 18059 Rostock (Germany) http://www.catalysis.de.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Junge
authors.affiliation: Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a, 18059 Rostock (Germany) http://www.catalysis.de. matthias.beller@catalysis.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
keywords: alcohols; carboxylic acids; homogeneous catalysis; hydrogenation; ruthenium