title: Serum S-100β and NSE levels after off-pump versus on-pump coronary artery bypass graft surgery.
abstract: BACKGROUND
  We aimed to evaluate serum levels of S-100 beta (S-100β) and neuron specific enolase (NSE) in patients with coronary heart disease (CHD) after off-pump versus on-pump coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  The PubMed (~2013) and the Chinese Biomedical Database (CBM) (1982 ~ 2013) were searched without language restrictions. After extraction of relevant data from selected studies, meta-analyses were conducted using STATA software (Version 12.0, Stata Corporation, College Station, Texas USA). Possible sources of heterogeneity were examined through univariate and multivariate meta-regression analyses and verified by Monte Carlo Simulation.
  
  
  RESULTS
  Eleven studies with a total of 411 CHD patients met the inclusion criteria. Our meta-analysis showed no significant difference in serum S-100β and NSE levels between the on-pump group and the off-pump group before surgery. In the on-pump group, there was a significant difference in serum S-100β levels of CHD patients between before and after surgery, especially within the first 24 h after surgery. Furthermore, in the on-pump group, there was a significant difference in serum NSE levels of CHD patients between before and after surgery, particularly at 0 h after surgery. In the off-pump group, there was an obvious difference in serum S-100β levels between before and after surgery, especially within 24 h after surgery. Our results also demonstrated that serum S-100β and NSE levels of CHD patients in the on-pump group were significantly higher than those of patients in the off-pump group, especially within 24 h after surgery.
  
  
  CONCLUSIONS
  Our findings provide empirical evidence that off-pump and on-pump CABG surgeries may increase serum S-100β and NSE levels in CHD patients, which was most prominent within 24 h after on-pump CABG surgery.
authors.affiliation: Department of Cardiovascular Surgery, Yantai Yuhuangding Hospital, No.20 Yuhuangding East Road, Yantai, 264000, P.R. China. zhenglei0107@126.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Cardiovascular Surgery, Yantai Yuhuangding Hospital, No.20 Yuhuangding East Road, Yantai, 264000, P.R. China. fanqinming0107@126.com.
authors.forename: Qing-Ming
authors.initials: QM
authors.lastname: Fan
authors.affiliation: Department of Cardiovascular Surgery, Yantai Yuhuangding Hospital, No.20 Yuhuangding East Road, Yantai, 264000, P.R. China. weizhenyu975@163.com.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Wei
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001026:Coronary Artery Bypass; D047549:Coronary Artery Bypass, Off-Pump; D003324:Coronary Artery Disease / Q000097:blood* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; D010751:Phosphopyruvate Hydratase