title: Blocking Cancer Growth with Less POMP or Proteasomes.
abstract: Although proteasomes are critical in cell regulation and cancer therapy, little is known about the factors regulating proteasome content or activity. In this issue, Zhang et al. (2015) report that miR-101 suppresses the expression of chaperone POMP and 20S assembly, and certain cancers raise proteasome content by losing miR-101.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: alfred_goldberg@hms.harvard.edu.
authors.forename: Alfred L
authors.initials: AL
authors.lastname: Goldberg
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Jinghui
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Galen A
authors.initials: GA
authors.lastname: Collins
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D018832:Molecular Chaperones / Q000235:genetics* / Q000378:metabolism*; D061988:Proteasome Inhibitors / Q000378:metabolism*
chemical_list: C534072:MIRN101 microRNA, human; D035683:MicroRNAs; D018832:Molecular Chaperones; D061988:Proteasome Inhibitors; C110856:proteasome maturation protein