title: Rapid improvement of glucagonoma-related necrolytic migratory erythema with octreotide.
abstract: Necrolytic migratory erythema (NME) is a classical paraneoplastic symptom observed in patients with pancreatic glucagonoma. We report a 46-year-old Japanese woman with glucagonoma who presented with mucocutaneous manifestations 1 year prior to the diagnosis of the pancreatic neoplasm with multiple liver metastases. She was treated with octreotide long-acting release, a somatostatin analog, which resulted in a dramatic improvement of NME within 2 weeks after the start of treatment. Increased awareness of NME may avoid unnecessary delay in the diagnosis of pancreatic glucagonoma.
authors.affiliation: Department of Clinical Oncology, Osaka City General Hospital, Osaka, Japan, kim130@hotmail.co.jp.
authors.forename: Shiro
authors.initials: S
authors.lastname: Kimbara
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Masanori
authors.initials: M
authors.lastname: Toyoda
authors.forename: Naoko
authors.initials: N
authors.lastname: Chayahara
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Imamura
authors.forename: Naomi
authors.initials: N
authors.lastname: Kiyota
authors.forename: Toru
authors.initials: T
authors.lastname: Mukohara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fukunaga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Oka
authors.forename: Chikako
authors.initials: C
authors.lastname: Nishigori
authors.forename: Hironobu
authors.initials: H
authors.lastname: Minami
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D005260:Female; D005935:Glucagonoma / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D058568:Necrolytic Migratory Erythema / Q000188:drug therapy* / Q000209:etiology*; D015282:Octreotide / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000209:etiology*; D012074:Remission Induction; D013997:Time Factors
chemical_list: D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide