title: Fluid-Structure Interaction Analysis of Papillary Muscle Forces Using a Comprehensive Mitral Valve Model with 3D Chordal Structure.
abstract: Numerical models of native heart valves are being used to study valve biomechanics to aid design and development of repair procedures and replacement devices. These models have evolved from simple two-dimensional approximations to complex three-dimensional, fully coupled fluid-structure interaction (FSI) systems. Such simulations are useful for predicting the mechanical and hemodynamic loading on implanted valve devices. A current challenge for improving the accuracy of these predictions is choosing and implementing modeling boundary conditions. In order to address this challenge, we are utilizing an advanced in vitro system to validate FSI conditions for the mitral valve system. Explanted ovine mitral valves were mounted in an in vitro setup, and structural data for the mitral valve was acquired with [Formula: see text]CT. Experimental data from the in vitro ovine mitral valve system were used to validate the computational model. As the valve closes, the hemodynamic data, high speed leaflet dynamics, and force vectors from the in vitro system were compared to the results of the FSI simulation computational model. The total force of 2.6 N per papillary muscle is matched by the computational model. In vitro and in vivo force measurements enable validating and adjusting material parameters to improve the accuracy of computational models. The simulations can then be used to answer questions that are otherwise not possible to investigate experimentally. This work is important to maximize the validity of computational models of not just the mitral valve, but any biomechanical aspect using computational simulation in designing medical devices.
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
authors.forename: Milan
authors.initials: M
authors.lastname: Toma
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
authors.forename: Morten Ø
authors.initials: MØ
authors.lastname: Jensen
authors.affiliation: Computational Biology & Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Einstein
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
authors.forename: Ajit P
authors.initials: AP
authors.lastname: Yoganathan
authors.affiliation: Department of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME, 04469-5711, USA.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Cochran
authors.affiliation: Department of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME, 04469-5711, USA. karyn.cochran@maine.edu.
authors.forename: Karyn S
authors.initials: KS
authors.lastname: Kunzelman
mesh_terms: D000818:Animals; D002815:Chordae Tendineae / Q000000981:diagnostic imaging / Q000502:physiology; D066298:In Vitro Techniques; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000502:physiology*; D008955:Models, Cardiovascular; D010210:Papillary Muscles / Q000000981:diagnostic imaging / Q000502:physiology*; D012756:Sheep; D055114:X-Ray Microtomography
keywords: Chordal structure; Comprehensive computational model; Fluid–structure interaction; Forces; Mitral valve; Papillary muscle