title: Poly(ADP-ribosylation) and neurodegenerative disorders.
abstract: Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed.
authors.affiliation: Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.
authors.forename: Davide Alessandro
authors.initials: DA
authors.lastname: Basello
authors.affiliation: Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100 Pavia, Italy. Electronic address: scovassi@igm.cnr.it.
authors.forename: Anna Ivana
authors.initials: AI
authors.lastname: Scovassi
mesh_terms: D016923:Cell Death; D006801:Humans; D024101:Mitochondrial Proteins / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000473:pathology*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*
chemical_list: D024101:Mitochondrial Proteins; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011506:Proteins; C024857:poly(ADP)-ribosylated proteins; D011064:Poly Adenosine Diphosphate Ribose
keywords: Apoptosis; Mitochondria; Mitophagy; Neurodegeneration; Parthanatos; Poly(ADP-ribosylation)