title: Factors influencing the spontaneous closure of ventricular septal defect in infants.
abstract: This study is to prospectively evaluate the potential value of maternal and infantile variables as predictors for the spontaneous ventricular septal defects (VSD) closure in infants.
  
  
  METHODS
  Consecutive infants less than six-month-old when diagnosed with VSD, were followed-up for at least 5 years. Demographic, clinical and maternal factors were evaluated for the possible associations of the incidence of spontaneous VSD closure Of the 425 eligible infants, 93 had spontaneous VSD closure, 78.50% of which occurred when the patients were under 3 years of age. Diameter of the defect (DVSD), ratio between diameter of the defect and aortic root diameter (DVSD/DAR), left atrium sizes, left ventricle sizes, main pulmonary forward blood flow, infection scores, shunt ratio (Qp/Qs), VSD locations, and comorbidities including patent ductus arteriosus (PDA), and membranous septal aneurysm were independent predictors of spontaneous closure. However, maternal factors during the first 3 months of pregnancy and VSD infants with Down syndrome did not affect the spontaneous closure of infants with VSD.
  
  
  CONCLUSIONS
  DVSD, DVSD/DAR, left atrium sizes, left ventricle sizes, main pulmonary forward blood flow, infection scores, Qp/Qs, VSD location, comorbidities including PDA, or membranous septal aneurysm may be used as potential independent predictors of spontaneous VSD closure in infants.
authors.affiliation: Center of Pediatrics, Institute of Pediatrics, First Affiliated Bethune Hospital, Jilin University Changchun 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Center of Pediatrics, Institute of Pediatrics, First Affiliated Bethune Hospital, Jilin University Changchun 130021, China.
authors.forename: Jinxiang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Center of Pediatrics, Institute of Pediatrics, First Affiliated Bethune Hospital, Jilin University Changchun 130021, China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Wang
authors.affiliation: Center of Pediatrics, Institute of Pediatrics, First Affiliated Bethune Hospital, Jilin University Changchun 130021, China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Center of Pediatrics, Institute of Pediatrics, First Affiliated Bethune Hospital, Jilin University Changchun 130021, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.affiliation: Center of Pediatrics, Institute of Pediatrics, First Affiliated Bethune Hospital, Jilin University Changchun 130021, China.
authors.forename: Sirui
authors.initials: S
authors.lastname: Yang
mesh_terms: D000367:Age Factors; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D015150:Echocardiography, Doppler; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D011652:Pulmonary Circulation; D012075:Remission, Spontaneous; D012307:Risk Factors; D013997:Time Factors
keywords: Ventricular septal defect; predictive factor; prognosis; spontaneous closure