title: Do vitamin D levels affect antibody titers produced in response to HPV vaccine?
abstract: In addition to its well-known effects on bone metabolism, vitamin D is an immunomodulating hormone. Serum vitamin D levels in males 18-25 years were measured at baseline, and HPV antibody titers were measured one month following the third quadrivalent HPV vaccine dose. Vitamin D levels were ≥ 30 ng/ml (normal) in 60 males and <30 ng/ml (low) in 113 males. Reverse cumulative distribution curves and scatter plots showed higher antibody titers with low vitamin D for all vaccine strains (P < 0.05). In linear regression analyses, antibody titers for all HPV strains were significantly higher among those with lower vitamin D levels and among younger participants (P < 0.05). These relationships add to the body of knowledge of the complex role of vitamin D in immunoregulation.
authors.affiliation: a Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.
authors.forename: Richard K
authors.initials: RK
authors.lastname: Zimmerman
authors.affiliation: a Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.
authors.forename: Chyongchiou Jeng
authors.initials: CJ
authors.lastname: Lin
authors.affiliation: a Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Raviotta
authors.affiliation: a Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.
authors.forename: Mary Patricia
authors.initials: MP
authors.lastname: Nowalk
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D006801:Humans; D007155:Immunologic Factors / Q000097:blood*; D008297:Male; D053918:Papillomavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007155:Immunologic Factors; D053918:Papillomavirus Vaccines; D014807:Vitamin D
keywords: HPV vaccine; human papillomavirus; immunogenicity; immunoregulation; vitamin D