title: Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012.
abstract: BACKGROUND
  Optimizing treatment outcomes for depression requires understanding of how evidence-based treatments are utilized in clinical practice. Antipsychotic medications concurrent with antidepressant treatment are frequently used in major depression, but few studies have investigated trends and patterns of their use over time. This study aimed to examine the prescription patterns of antipsychotic medications for major depression in China from 2002 to 2012 and their association with treatment satisfaction and quality of life (QOL).
  
  
  METHODS
  A total of 3655 subjects with major depression treated in 45 Chinese psychiatric hospitals/centers nationwide were interviewed between 2002 and 2012. Patients' socio-demographic and clinical characteristics including psychopathology, medication side effects, satisfaction with treatment and QOL were recorded using a standardized protocol and data collection.
  
  
  RESULTS
  The frequency of antipsychotic use was 24.9% in the whole sample; the corresponding figures were 17.1%, 20.3%, and 32.8% in 2002, 2006, and 2012, respectively (χ2 = 90.3, df = 2, P < 0.001). Multiple logistic regression analyses revealed that patients on concurrent antipsychotics had significantly more delusions or hallucinations, longer illness duration, greater side effects, and more likely to be treated as inpatients and in major hospitals (i.e., Level-III hospital). Antipsychotic use was associated with lower treatment satisfaction while there was no significant difference with respect to physical and mental QOL between the antipsychotic and nonantipsychotic groups.
  
  
  CONCLUSIONS
  Concurrent antipsychotic use was found in about one in four treated depressed patients in China, which has increased over a 10-year period. Considering the association of drug-induced side effects and the lack of patients' and relatives' satisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of the use of antipsychotics in depression is needed.
authors.forename: Yu-Xi
authors.initials: YX
authors.lastname: Wang
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Xiang
authors.forename: Yun-Ai
authors.initials: YA
authors.lastname: Su
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Shu
authors.forename: Chee H
authors.initials: CH
authors.lastname: Ng
authors.forename: Gabor S
authors.initials: GS
authors.lastname: Ungvari
authors.forename: Helen Fk
authors.initials: HF
authors.lastname: Chiu
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Nin
authors.forename: Gao-Hua
authors.initials: GH
authors.lastname: Wang
authors.forename: Pei-Shen
authors.initials: PS
authors.lastname: Bai
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Li-Zhong
authors.initials: LZ
authors.lastname: Sun
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Shi
authors.forename: Xian-Sheng
authors.initials: XS
authors.lastname: Chen
authors.forename: Qi-Yi
authors.initials: QY
authors.lastname: Mei
authors.forename: Ke-Qing
authors.initials: KQ
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.affiliation: National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital/Institute of Mental Health), and The Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Tian-Mei
authors.initials: TM
authors.lastname: Si
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010549:Personal Satisfaction; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011788:Quality of Life
chemical_list: D014150:Antipsychotic Agents; D011619:Psychotropic Drugs