title: Antiplasmodial Activity and Cytotoxicity of Plants Used in Traditional Medicine of Iran for the Treatment of Fever.
abstract: Malaria is the most serious parasitic disease and one of the oldest recorded diseases in the world. Because of the resistance of malaria parasites to current drugs, it is necessary to discover new antiplasmodial drugs. Traditional medicine is one of the important sources of new antiplasmodial drugs. In this study, twenty methanolic extracts from different parts of sixteen medicinal plants used in traditional medicine of Iran for the treatment of "Nobeh fever" and/ or fever were screened for in-vivo antiplasmodial activity against Plasmodium berghei and cytotoxic effect on Madin-Darby bovine kidney cells (MDBK). Eleven species (55%) were found to have antiplasmodial activity. Methanolic extract from Rosa damascena Mill. reduced parasitemia by 57.7% compared to untreated control mice at intra-peritoneal (i.p.) injection doses of 10 mg/Kg per day for 4 days. This is the first report that mentioned in-vivo antiplasmodial activity of Rosa damascena Mill.
authors.affiliation: Traditional Medicine and Materia Medica Research Centre (TMRC), Shahid Beheshti University of Medical Sciences. Tehran, Iran. ; Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Esmaeili
authors.affiliation: Traditional Medicine and Materia Medica Research Centre (TMRC), Shahid Beheshti University of Medical Sciences. Tehran, Iran. ; Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Ghiaee
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Traditional Medicine and Materia Medica Research Centre (TMRC), Shahid Beheshti University of Medical Sciences. Tehran, Iran. ; Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Naghibi
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Traditional Medicine and Materia Medica Research Centre (TMRC), Shahid Beheshti University of Medical Sciences. Tehran, Iran. ; Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mosaddegh
keywords: Antiplasmodial; Fever; Malaria; Rosa damascene; Traditional medicine