title: Metastatic Chordoma: Report of the Two Cases and Review of the Literature.
abstract: Chordomas are rare malignant bone tumours with a predilection for the axial skeleton, especially the sacrum and skull base. Median survival in patients with metastatic disease is usually dismal. Treatment is challenging due to the propensity for local recurrence, metastatic disease as well as lack of clear consensus regarding the optimal management. Our case report highlights two cases of sacral chordoma with locally recurrent and widespread metastatic disease, stable on molecular targeted therapy.
authors.affiliation: Brigham and Women's Hospital/Dana Farber Cancer institute/ Harvard Medical School - Radiology Boston, Massachusetts, USA.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Rohatgi
authors.affiliation: Brigham and Women's Hospital/Dana Farber Cancer institute/ Harvard Medical School - Radiology Boston, Massachusetts, USA.
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Ramaiya
authors.affiliation: Brigham and Women's Hospital/Dana Farber Cancer institute/ Harvard Medical School - Radiology Boston, Massachusetts, USA.
authors.forename: Jyothi P
authors.initials: JP
authors.lastname: Jagannathan
authors.affiliation: Brigham and Women's Hospital/Dana Farber Cancer institute/ Harvard Medical School - Radiology Boston, Massachusetts, USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Howard
authors.affiliation: Brigham and Women's Hospital/Dana Farber Cancer institute/ Harvard Medical School - Radiology Boston, Massachusetts, USA.
authors.forename: Atul B
authors.initials: AB
authors.lastname: Shinagare
authors.affiliation: Brigham and Women's Hospital/Dana Farber Cancer institute/ Harvard Medical School - Radiology Boston, Massachusetts, USA.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Krajewski
keywords: Chordoma; Kordoma; imatinib; metastasis; metastaz; positron emission tomography; pozitron emisyon tomografi