title: Overexpression of HLA-DR is associated with prognosis of glioma patients.
abstract: OBJECTIVE
  Since the poor prognosis of glioma, our study was aimed to find out the role of HLA-DR in the prognosis of glioma patients that may contribute to the timely post-operative treatment on the glioma patients.
  
  
  METHODS
  60 glioma patients were enrolled in the prospective cohort study. Western blotting was used to detect the content of HLA-DR. Kaplan-Meier curve was adopted to evaluate the effects of HLA-DR on the survival time of glioma patients. Cox regression analysis was used to evaluate the roles of clinical features and HLA-DR in the pathogenesis of glioma.
  
  
  RESULTS
  The expression level of HLA-DR was higher in tumor tissue, compared with normal tissues (P<0.05). Moreover, expression levels of HLA-DR were correlated with the factors of pathological degree, Enneking staging and KPS score. The survival rate of patients with high content of HLA-DR was lower than those of patients with low content of HLA-DR. Cox regression analysis indicated that Enneking staging and HLA-DR were all associated with the prognosis of glioma (HR=14.43, 95% CI=1.05-199.16; HR=21.39, 95% CI=2.07-220.76).
  
  
  CONCLUSIONS
  HLA-DR may serve as a biomarker for the prognosis of glioma patients.
authors.affiliation: Chinese PLA Medical School, Department of Neurosurgery, The First Affliated Hospital of Chinese PLA General Hospital 51 Fuchengmen Road, Haidian District, Beijing 100048, China ; Department of Neurosurgery, General Hospital of Armed Police Forces 69 Yongding Road, Haidian District, Beijing 100039, China.
authors.forename: Jinfu
authors.initials: J
authors.lastname: Diao
authors.affiliation: Department of Dermatology, 306 Hospital of PLA Chaoyang District, Beijing 100101, China.
authors.forename: Tianbao
authors.initials: T
authors.lastname: Xia
authors.affiliation: Department of Neurosurgery, 306 Hospital of PLA Chaoyang District, Beijing 100101, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Chinese PLA Medical School, Department of Neurosurgery, The First Affliated Hospital of Chinese PLA General Hospital 51 Fuchengmen Road, Haidian District, Beijing 100048, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, 306 Hospital of PLA Chaoyang District, Beijing 100101, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Chinese PLA Medical School, Department of Neurosurgery, The First Affliated Hospital of Chinese PLA General Hospital 51 Fuchengmen Road, Haidian District, Beijing 100048, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006684:HLA-DR Antigens / Q000378:metabolism*; D006801:Humans; D011379:Prognosis; D015996:Survival Rate
chemical_list: D006684:HLA-DR Antigens
keywords: HLA-DR; glioma; prognosis