title: The codon 72 polymorphism of the TP53 gene and endometriosis risk: a meta-analysis.
abstract: Endometriosis is a chronic, inflammatory and common gynaecological disease. This study investigated the association between TP53 codon 72 polymorphism and the risk of endometriosis. A search for relevant articles was conducted in PubMed, Embase, CNKI, Wanfang, Weipu databases and Google Scholar. The strength of the relationships between TP53 codon 72 polymorphism and the risk of endometriosis was assessed by odds ratios (OR) and with 95% confidence intervals (CI). Sixteen case-control studies in 15 articles were included. Significant association was found in the dominant model (CC + GC versus GG) with an OR of 1.38 and 95% CI (1.14, 1.67). The results suggested that individuals who carried CC homozygote and heterozygote GC might have a 38% increased endometriosis risk when compared with the homozygote GG. In the subgroup analysis by ethnicity, significantly increased risk was observed among Asians (OR = 1.62, 95% CI = 1.18-2.23, P = 0.003) and Latin Americans (OR = 1.54, 95% CI = 1.16-2.03, P = 0.002) but not in Caucasians (OR = 1.02, 95% CI = 0.80-1.30) for the dominant model. The current meta-analysis suggested that TP53 codon 72 polymorphism was associated with the endometriosis risk, especially in Asians and Latin Americans.
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Gynecology and Obstetrics, Affiliated Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, 530011, Guangxi, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Wu
authors.affiliation: Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Gynecology and Obstetrics, Affiliated Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, 530011, Guangxi, China.
authors.forename: Zhi-Juan
authors.initials: ZJ
authors.lastname: Luo
authors.affiliation: Department of Gynecology and Obstetrics, Affiliated Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, 530011, Guangxi, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Gynecology and Obstetrics, Affiliated Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, 530011, Guangxi, China.
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Zhou
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yi
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Lin
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Qian-Ying
authors.initials: QY
authors.lastname: Zhao
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan, China; The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address: zhaoxia2015@126.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
mesh_terms: D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: TP53; endometriosis; meta-analysis; polymorphism