title: Iodine-Promoted Construction of Polysubstituted 2,3-Dihydropyrroles from Chalcones and β-Enamine Ketones (Esters).
abstract: A novel approach for the synthesis of a variety of polysubstituted trans-2,3-dihydropyrroles from a wide range of chalcones and β-enamine ketones (esters) via iodine-promoted tandem Michael/cyclization sequence has been developed, affording the desired products in moderate to excellent yields. This methodology is a highly efficient, convenient way to access functionalized 2,3-dihydropyrroles from readily accessible substrates under mild reaction conditions.
authors.affiliation: †College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Li
authors.affiliation: †College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.affiliation: †College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
authors.forename: Mengming
authors.initials: M
authors.lastname: Xing
authors.affiliation: ‡Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.affiliation: †College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Jia
authors.affiliation: †College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Gao
mesh_terms: D002384:Catalysis; D047188:Chalcones / Q000737:chemistry*; D004952:Esters; D007455:Iodine / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D047188:Chalcones; D004952:Esters; D007659:Ketones; D011758:Pyrroles; D007455:Iodine