title: Chemical Constituents of the Underground Parts of Iris florentina and their Cytotoxic Activity.
abstract: Three new isoflavonoid glycosides (1, 5, and 9) and 10 known compounds (2-4, 6-8, and 10-13) were isolated from the underground parts of Iris florentina (Iridaceae). The structures of the new compounds were determined based on extensive spectroscopic data and the results of hydrolytic cleavage. The isolated compounds and the aglycones were evaluated for cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 12 induced apoptotic cell death in the HL-60 cells.
authors.forename: Akihito
authors.initials: A
authors.lastname: Yokosuka
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Koyama
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mimaki
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000633:toxicity; D018922:HL-60 Cells; D006801:Humans; D031323:Iris Plant / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts