title: Elevated Plasma Soluble CD14 Levels Correlate with the Monocyte Response Status During Hantaan Virus Infection in Humans.
abstract: Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans. CD14, a pattern recognition receptor recognizing lipopolysaccharide, is highly expressed on monocytes and can be shed as soluble CD14 (sCD14) upon monocyte activation. To understand the role of sCD14 in HFRS, the sCD14 plasma concentrations from 45 HFRS patients were quantified, and the relationships between the plasma sCD14 level and the monocyte response status and clinical parameters were analyzed. The plasma sCD14 levels were significantly higher in the HFRS patients and they correlated with monocyte expansion and activation, which were characterized by increased blood monocyte counts, the proportion of CD14(++)CD16(+) intermediate monocytes, as well as elevated plasma tumor necrosis factor-α (TNF-α) and soluble CD163 (sCD163) levels. Additionally, the high plasma sCD14 levels positively correlated with white blood cell counts and blood urea nitrogen levels and negatively correlated with platelet counts in the HFRS patients. Taken together, our data indicate that elevated plasma sCD14 levels are associated with the monocyte response status during HTNV infection in humans.
authors.affiliation: Department of Immunology, The Fourth Military Medical University , Xi'an, China .
authors.forename: Kang
authors.initials: K
authors.lastname: Tang
authors.affiliation: Department of Immunology, The Fourth Military Medical University , Xi'an, China .
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Immunology, The Fourth Military Medical University , Xi'an, China .
authors.forename: Yusi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Immunology, The Fourth Military Medical University , Xi'an, China .
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Immunology, The Fourth Military Medical University , Xi'an, China .
authors.forename: Ran
authors.initials: R
authors.lastname: Zhuang
authors.affiliation: Department of Immunology, The Fourth Military Medical University , Xi'an, China .
authors.forename: Boquan
authors.initials: B
authors.lastname: Jin
authors.affiliation: Department of Immunology, The Fourth Military Medical University , Xi'an, China .
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood; D001806:Blood Urea Nitrogen; D005260:Female; D018063:Hantaan virus / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000473:pathology*; D006801:Humans; D007958:Leukocyte Count; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D010949:Plasma / Q000737:chemistry*; D010976:Platelet Count; D011956:Receptors, Cell Surface / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D018950:Lipopolysaccharide Receptors; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha