title: New intraprostatic injectables and prostatic urethral lift for male LUTS.
abstract: Treatment modalities for male lower urinary tract symptoms (LUTS) comprise a broad spectrum of medical and surgical options. Interest is growing in minimally invasive treatment options, which should ideally be performed in an outpatient setting and have a short recovery time, durable efficacy and a good safety profile. The preservation of all aspects of sexual function, including antegrade ejaculation, seems to be increasingly important for patients. Initial experimental data on new minimally invasive procedures-such as the intraprostatic injection of novel agents including botulinum neurotoxin A (BoNT-A), NX-1207 and PRX302-were promising, but clinical trials have not confirmed the findings. Trials of the mechanical prostatic urethral lift device-Urolift(®) (Neotract, Inc., USA)-have been positive, but further long-term results are needed to confirm its beneficial effects.
authors.affiliation: Urologische Klinik und Poliklinik, Klinikum der Universität München-Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377 Munich, Germany.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Magistro
authors.affiliation: Urologische Klinik und Poliklinik, Klinikum der Universität München-Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377 Munich, Germany.
authors.forename: Christian G
authors.initials: CG
authors.lastname: Stief
authors.affiliation: Urologische Klinik und Poliklinik, Klinikum der Universität München-Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377 Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Gratzke
mesh_terms: D001427:Bacterial Toxins / Q000008:administration & dosage; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage; D006801:Humans; D007267:Injections; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D009465:Neuromuscular Agents / Q000008:administration & dosage; D052899:Pore Forming Cytotoxic Proteins / Q000008:administration & dosage; D011467:Prostate; D019736:Prostheses and Implants; D014521:Urethra
chemical_list: D001427:Bacterial Toxins; D009465:Neuromuscular Agents; C518473:PRX302; D052899:Pore Forming Cytotoxic Proteins; D019274:Botulinum Toxins, Type A