title: Adaptability to changes in temporal structure is fornix-dependent.
abstract: Recognition memory deficits, even after short delays, are sometimes observed following hippocampal damage. One hypothesis links the hippocampus with processes in updating contextual memory representation. Here, we used fornix transection, which partially disconnects the hippocampal system, and compares the performance of fornix-transected monkeys with normal monkeys on two versions of a delayed-matching-to-position task with short delays. Spatial recognition memory was affected by fornix transection only when the temporal structure of the task changed across trials, while differences in motor control, motivation, perception, or short-term memory were not critical. We attributed the deficit to a compromised ability in tracking changes in task temporal structure.
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China NYU-ECNU Institute of Brain and Cognitive Science, NYU-Shanghai University, Shanghai 200062, China Neuroimaging Laboratory, Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome 00179, Italy Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom sze-chai.kwok@st-hughs.oxon.org.
authors.forename: Sze Chai
authors.initials: SC
authors.lastname: Kwok
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom.
authors.forename: Anna S
authors.initials: AS
authors.lastname: Mitchell
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Buckley
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D020712:Fornix, Brain / Q000293:injuries / Q000502:physiology*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009042:Motivation / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D009483:Neuropsychological Tests; D011930:Reaction Time; D021641:Recognition, Psychology / Q000502:physiology*; D065852:Spatial Memory / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*