title: Biomarkers of delayed graft function as a form of acute kidney injury in kidney transplantation.
abstract: Renal transplantation ensures distinct advantages for patients with end-stage kidney disease. However, in some cases early complications can lead to allograft dysfunction and consequently graft loss. One of the most common early complications after kidney transplantation is delayed graft function (DGF). Unfortunately there is no effective treatment for DGF, however early diagnosis of DGF and therapeutic intervention (eg modification of immunosuppression) may improve outcome. Therefore, markers of acute kidney injury are required. Creatinine is a poor biomarker for kidney injury due principally to its inability to help diagnose early acute renal failure and complete inability to help differentiate among its various causes. Different urinary and serum proteins have been intensively investigated as possible biomarkers in this setting. There are promising candidate biomarkers with the ability to detect DGF. We focused on emerging biomarkers of DGF with NGAL is being the most studied followed by KIM-1, L-FABP, IL-18, and others. However, large randomized studies are needed to establish the value of new, promising biomarkers, in DGF diagnosis, prognosis and its cost-effectiveness.
authors.affiliation: 2nd Department of Nephrology, Medical University, Bialystok, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Malyszko
authors.affiliation: 2nd Department of Nephrology, Medical University, Bialystok, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Lukaszyk
authors.affiliation: 2nd Department of Nephrology, Medical University, Bialystok, Poland.
authors.forename: Irena
authors.initials: I
authors.lastname: Glowinska
authors.affiliation: Department of Nephrology and Transplantation Medicine, Warsaw Medical University, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Durlik
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000209:Acute-Phase Proteins / Q000652:urine; D054392:Adipokines / Q000652:urine; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D000071451:Chitinase-3-Like Protein 1; D051152:Clusterin / Q000652:urine; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000652:urine; D051799:Delayed Graft Function; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D020382:Interleukin-18 / Q000652:urine; D016030:Kidney Transplantation; D037102:Lectins / Q000652:urine; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine; D008562:Membrane Glycoproteins / Q000032:analysis / Q000652:urine; D011518:Proto-Oncogene Proteins / Q000652:urine; D011991:Receptors, Virus / Q000032:analysis; D014184:Transplantation, Homologous
chemical_list: D000209:Acute-Phase Proteins; D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D051152:Clusterin; D055316:Cystatin C; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D020382:Interleukin-18; C489506:LCN2 protein, human; D037102:Lectins; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus; D003404:Creatinine