title: Effects of Natural Products on Mcl-1 Expression and Function.
abstract: Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.
authors.forename: Florian
authors.initials: F
authors.lastname: Muller
authors.forename: Claudia
authors.initials: C
authors.lastname: Cerella
authors.forename: Flavia
authors.initials: F
authors.lastname: Radogna
authors.forename: Mario
authors.initials: M
authors.lastname: Dicato
authors.affiliation: College of Pharmacy, Seoul National University, Building 29 Room 233, 1 Gwanak-ro, Gwanak- gu, Seoul, 151-742, Korea. marcdiederich@snu.ac.kr.
authors.forename: Marc
authors.initials: M
authors.lastname: Diederich
mesh_terms: D001688:Biological Products / Q000494:pharmacology*; D002298:Cardenolides / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D064549:Myeloid Cell Leukemia Sequence 1 Protein / Q000235:genetics* / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism
chemical_list: D001688:Biological Products; D002298:Cardenolides; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2; C510008:UNBS 1450