title: Tailored immunogens for rationally designed antibody-based HIV-1 vaccines.
abstract: Protective HIV-1 vaccines would require the induction of broadly neutralizing antibodies (bNAbs) to be effective against the vast diversity of circulating viral strains. Three new studies provide in vivo demonstration that rational design of vaccine strategies using engineered and native-like HIV-1 immunogens can be exploited for guiding B-cell evolution towards the genesis of HIV-1 bNAbs.
authors.affiliation: Laboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France; CNRS-URA 1961, Paris, France. Electronic address: hugo.mouquet@pasteur.fr.
authors.forename: Hugo
authors.initials: H
authors.lastname: Mouquet
mesh_terms: D016915:AIDS Vaccines / Q000737:chemistry* / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D015483:HIV Antibodies / Q000276:immunology*; D015488:HIV Antigens / Q000737:chemistry* / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D006801:Humans
chemical_list: D016915:AIDS Vaccines; D015483:HIV Antibodies; D015488:HIV Antigens