title: [CHRONIC MYELOID LEUKEMIA IN A YOUNG MALE PRESENTING WITH BILATERAL CALF PAIN DUE TO LEUKOSTASIS].
abstract: Chronic myeloid Leukemia (CML) is a chronic myeloproliferative disorder, caused by the unregulated proliferation of granulocytes at different stages of development and maturation. Leukostasis is one of the complications of CML, causing partial or total occlusion of microvasculature with a variety of clinical manifestations, mostly ophthalmic, neurologic or respiratory. Recently, we encountered a 21-year old soldier, who complained of severe bilateral calf pain which began a few months earlier during training. He underwent complete ambulatory orthopedic evaluation which was unrevealing, and finally presented to the hospital casualty department where CML was diagnosed on the basis of an elevated WBC count and morphologic findings. Bilateral retinal hemorrhages due to leukostasis were noticed at fundoscopy. The calf pain resolved completely after leukapheresis and initial cytoreductive therapy and was in retrospect attributed to peripheral leukostasis. To the best of our knowledge this is the first report of CML presenting with bilateral calf pain due to Leukocytosis and possible leukostasis. This case report highlights the importance of differential diagnosis in cases of calf pain and the awareness of this rare manifestation of CML.
authors.forename: Misgav
authors.initials: M
authors.lastname: Rottenstreich
authors.forename: Michael
authors.initials: M
authors.lastname: Lavie
authors.forename: Amihai
authors.initials: A
authors.lastname: Rottenstreich
mesh_terms: D000493:Allopurinol / Q000008:administration & dosage*; D001856:Bone Marrow Examination / Q000379:methods; D000069439:Dasatinib; D003937:Diagnosis, Differential; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage*; D007866:Leg / Q000473:pathology / Q000503:physiopathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D007958:Leukocyte Count / Q000379:methods; D018921:Leukostasis / Q000209:etiology / Q000503:physiopathology; D008297:Male; D063806:Myalgia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D009887:Ophthalmoscopy / Q000379:methods; D010677:Philadelphia Chromosome; D011743:Pyrimidines / Q000008:administration & dosage*; D012166:Retinal Hemorrhage / Q000175:diagnosis / Q000209:etiology; D013844:Thiazoles / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004791:Enzyme Inhibitors; D011743:Pyrimidines; D013844:Thiazoles; D000493:Allopurinol; D000069439:Dasatinib; D006918:Hydroxyurea