title: Biochemical Testing After Pheochromocytoma Removal: How Early?
abstract: Pheochromocytomas are catecholamine-producing tumors with typical clinical presentation. Tumor resection is considered as an appropriate treatment strategy. Due to its unpredictable clinical behavior, biochemical testing is mandatory to confirm the success of tumor removal after surgery. The aim of the study was to investigate the feasibility of a shorter interval of postoperative testing (earlier than the recommended 2-4 weeks according to recently published Guidelines). We investigated 81 patients with pheochromocytoma before and after surgery. Postoperative examination was performed of stable subjects after their transport from the surgical to the internal ward (7.1±2.2 days after surgery). Plasma metanephrines were used for the diagnosis of pheochromocytoma and confirmation of successful tumor removal. All subjects with pheochromocytoma had markedly elevated plasma metanephrines before surgery. No correlation between postoperative interval (the shortest being 3 days) and plasma metanephrine levels was found. Postoperative plasma metanephrine levels did not differ significantly from those taken at the one-year follow-up. In conclusion, we have shown that early postoperative diagnostic workup of subjects with pheochromocytoma is possible and may thus simplify early postoperative management of this clinical condition.
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Zelinka
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: O
authors.initials: O
authors.lastname: Petrák
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: B
authors.initials: B
authors.lastname: Hamplová
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: H
authors.initials: H
authors.lastname: Turková
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Third Faculty of Medicine, Charles University and Hospital Královské Vinohrady, Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Waldauf
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Rosa
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Šomlóová
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Holaj
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: B
authors.initials: B
authors.lastname: Štrauch
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Indra
authors.affiliation: 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Kršek
authors.forename: A
authors.initials: A
authors.lastname: Brabcová Vránková
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: A Brabcová
authors.initials: AB
authors.lastname: Vránková
authors.affiliation: Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Musil
authors.affiliation: Institute of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Dušková
authors.affiliation: Institute of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Kubinyi
authors.affiliation: 1st Department of Surgery - Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: D
authors.initials: D
authors.lastname: Michalský
authors.affiliation: Department of Urology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Novák
authors.affiliation: Center for Hypertension, 3rd Medical Department - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Widimský
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood* / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008676:Metanephrine / Q000097:blood*; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010673:Pheochromocytoma / Q000097:blood* / Q000601:surgery*; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D008676:Metanephrine