title: Diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama disease) in Japan.
abstract: Diffuse neurofibrillary tangles with calcification (DNTC) is a rare, pre-senile type of dementia. The term 'DNTC' was initially proposed by Kosaka in 1994. Although 26 autopsies and 21 clinical patients with DNTC have been described in Japan to date, DNTC has rarely been reported in the European and North American published work. We speculate that DNTC has been overlooked in other countries. Herein, we review all known reports of DNTC in Japan and propose clinical diagnostic criteria for DNTC.
authors.affiliation: Department of Psychogeriatrics, Kamiiida Daiichi General Hospital, Nagoya, Japan.|Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Ukai
authors.affiliation: Clinic Ian Center Minami, Yokohama, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D055956:Diffuse Neurofibrillary Tangles with Calcification / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology
keywords: Fahr's disease; Kosaka-Shibayama disease; clinical diagnostic criteria; diffuse neurofibrillary tangles with calcification; pre-senile dementia