title: Vascular stem/progenitor cells: current status of the problem.
abstract: Stem/progenitor cells residing in the vascular wall of post-natal vessels play a crucial role in angiogenesis and vascular regeneration after damage. There are four major populations of vascular-resident stem/progenitor cells with differentiated clonogenic and proliferative potential, namely mesenchymal stem cells, pericytes, endothelial progenitor cells, and smooth muscle progenitor cells. These progenitors reside in vascular stem cell niches, which are more likely to be in the adventitia, a vascular wall layer in which increased concentration of stem cell surface markers has been shown. Indeed, vascular resident progenitors are not uniformly distributed across the vessel wall and the circulatory system. The heterogeneity of such a distribution could contribute to the differentiated susceptibility of various vessel regions to chronic vascular diseases such as atherosclerosis. In cardiovascular pathology, adult vascular resident progenitors could play either a negative or a positive role.
authors.affiliation: Faculty of Medicine, School of Medical Sciences, University of New South Wales, Kensington, Sydney, NSW, 2052, Australia. y.bobryshev@unsw.edu.au.
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Bobryshev
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow, 125315, Russia.|Institute for Atherosclerosis, Skolkovo Innovative Center, Moscow, 143025, Russia.|Department of Biophysics, Biological Faculty, Moscow State University, Moscow, 119991, Russia.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Orekhov
authors.affiliation: The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA.
authors.forename: Dimitry A
authors.initials: DA
authors.lastname: Chistiakov
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
keywords: Atherosclerosis; Blood vessels; Stem/progenitor cells; Vascular pathology; Vascular wall