title: A vascular perspective on neuronal migration.
abstract: During CNS development and adult neurogenesis, immature neurons travel from the germinal zones towards their final destination using cellular substrates for their migration. Classically, radial glia and neuronal axons have been shown to act as physical scaffolds to support neuroblast locomotion in processes known as gliophilic and neurophilic migration, respectively (Hatten, 1999; Marin and Rubenstein, 2003; Rakic, 2003). In adulthood, long distance neuronal migration occurs in a glial-independent manner since radial glia cells differentiate into astrocytes after birth. A series of studies highlight a novel mode of neuronal migration that uses blood vessels as scaffolds, the so-called vasophilic migration. This migration mode allows neuroblast navigation in physiological and also pathological conditions, such as neuronal precursor migration after ischemic stroke or cerebral invasion of glioma tumor cells. Here we review the current knowledge about how vessels pave the path for migrating neurons and how trophic factors derived by glio-vascular structures guide neuronal migration both during physiological as well as pathological processes.
authors.affiliation: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt, Germany; Focus Program Translational Neurosciences (FTN), University of Mainz, Germany; Max Planck Institute for Brain Research, Frankfurt, Germany. Electronic address: segarra@bio.uni-frankfurt.de.
authors.forename: Marta
authors.initials: M
authors.lastname: Segarra
authors.affiliation: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt, Germany; Focus Program Translational Neurosciences (FTN), University of Mainz, Germany; Max Planck Institute for Brain Research, Frankfurt, Germany.
authors.forename: Bettina C
authors.initials: BC
authors.lastname: Kirchmaier
authors.affiliation: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt, Germany; Focus Program Translational Neurosciences (FTN), University of Mainz, Germany; Max Planck Institute for Brain Research, Frankfurt, Germany. Electronic address: Acker-Palmer@bio.uni-frankfurt.de.
authors.forename: Amparo
authors.initials: A
authors.lastname: Acker-Palmer
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology*; D055495:Neurogenesis / Q000502:physiology; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000166:cytology*
keywords: Endothelium; Glioma; Ischemia; Neuroblasts; Neuronal migration; Vasophilic migration