title: Osteopetrosis: a Case of 'Hostile Chest' Associated with Symptomatic Aortic Valve Stenosis.
abstract: Osteopetrosis is a heterogeneous group of heritable conditions in which there is a defect in bone resorption by osteoclasts. It is associated with an increased skeletal mass due to abnormally dense, but brittle, bones. Osteopetrosis varies greatly in severity, and fracture treatment remains a matter of controversy due to altered responses to fixation and the risk of osteomyelitis. The fate of sternotomy in this condition is unknown, and osteopetrosis could represent a situation of 'hostile chest'. Here, the case is described of a patient with osteopetrosis and concomitant symptomatic aortic valve stenosis and coronary artery disease.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Villa
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
authors.forename: Antonio
authors.initials: A
authors.lastname: Messina
authors.forename: Andrea
authors.initials: A
authors.lastname: Rizzi
authors.forename: Angela
authors.initials: A
authors.lastname: D'Ambrosio
authors.forename: Ornella
authors.initials: O
authors.lastname: Leonzi
authors.forename: Tony
authors.initials: T
authors.lastname: Sabatini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Troise
mesh_terms: D001021:Aortic Valve / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D002114:Calcinosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006328:Cardiac Catheterization / Q000379:methods*; D000075202:Contraindications; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010022:Osteopetrosis / Q000150:complications* / Q000175:diagnosis; D062645:Percutaneous Coronary Intervention; D018570:Risk Assessment; D012307:Risk Factors; D056346:Sternotomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome