title: Technical Report: Correlation Between the Repair of Cartilage and Subchondral Bone in an Osteochondral Defect Using Bilayered, Biodegradable Hydrogel Composites.
abstract: The present work investigated correlations between cartilage and subchondral bone repair, facilitated by a growth factor-delivering scaffold, in a rabbit osteochondral defect model. Histological scoring indices and microcomputed tomography morphological parameters were used to evaluate cartilage and bone repair, respectively, at 6 and 12 weeks. Correlation analysis revealed significant associations between specific cartilage indices and subchondral bone parameters that varied with location in the defect (cortical vs. trabecular region), time point (6 vs. 12 weeks), and experimental group (insulin-like growth factor-1 only, bone morphogenetic protein-2 only, or both growth factors). In particular, significant correlations consistently existed between cartilage surface regularity and bone quantity parameters. Overall, correlation analysis between cartilage and bone repair provided a fuller understanding of osteochondral repair and can help drive informed studies for future osteochondral regeneration strategies.
authors.affiliation: 1 Department of Bioengineering, Rice University , Houston, Texas.
authors.forename: Steven
authors.initials: S
authors.lastname: Lu
authors.affiliation: 1 Department of Bioengineering, Rice University , Houston, Texas.
authors.forename: Johnny
authors.initials: J
authors.lastname: Lam
authors.affiliation: 1 Department of Bioengineering, Rice University , Houston, Texas.
authors.forename: Jordan E
authors.initials: JE
authors.lastname: Trachtenberg
authors.affiliation: 1 Department of Bioengineering, Rice University , Houston, Texas.
authors.forename: Esther J
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: 1 Department of Bioengineering, Rice University , Houston, Texas.
authors.forename: Hajar
authors.initials: H
authors.lastname: Seyednejad
authors.affiliation: 2 Department of Biomaterials, Radboudumc , Nijmegen, The Netherlands .
authors.forename: Jeroen J J P
authors.initials: JJ
authors.lastname: van den Beucken
authors.affiliation: 3 Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University , Kyoto, Japan .
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
authors.affiliation: 4 Department of Orthodontics, University of Texas School of Dentistry at Houston , Houston, Texas.
authors.forename: F Kurtis
authors.initials: FK
authors.lastname: Kasper
authors.affiliation: 5 Department of Statistics, Rice University , Houston, Texas.
authors.forename: David W
authors.initials: DW
authors.lastname: Scott
authors.affiliation: 6 Department of Oral and Maxillofacial Surgery, University of Texas School of Dentistry at Houston , Houston, Texas.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Wong
authors.affiliation: 2 Department of Biomaterials, Radboudumc , Nijmegen, The Netherlands .
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
authors.affiliation: 1 Department of Bioengineering, Rice University , Houston, Texas.
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Mikos
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D002356:Cartilage / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020100:Hydrogels / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D011817:Rabbits
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D020100:Hydrogels; C583557:IGF1 protein, human; D007334:Insulin-Like Growth Factor I