title: Immunogenicity, Immunopathogenicity, and Immunotolerance in One Graph.
abstract: The concept according to which unique, rare and common sequences may define immunogenicity, immunopathogenicity and immunotolerance, respectively, is graphically illustrated using a melanoma-associated antigen, Melan-A/Mart-1, as a model. The final picture is consolidated by experimentally validated data from the scientific literature and may represent a concrete prelude to effective immunotherapies exempt from collateral autoimmune reactions.
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona, 4, Bari - 70125, Italy. darja.kanduc@uniba.it.
authors.forename: Darja
authors.initials: D
authors.lastname: Kanduc
mesh_terms: D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology* / Q000628:therapy