title: Bone Mineral Density Changes in the Hip and Spine of Men and Women 1-Year After Primary Cemented Total Knee Arthroplasty: Prospective Cohort Study.
abstract: This study evaluated age- and sex-adjusted changes in total hip and spine bone mineral density (BMD) within 1 year of total knee arthroplasty (TKA) using a prospective, longitudinal cohort with a one-year follow-up. Preoperatively, subjects underwent routine bone mineral densitometry of their hip and spine, which was repeated 12 months postoperatively. Of 108 subjects, 97 (90%) completed BMD testing. Total hip BMD decreased significantly over time (1.80% change, P<0.001) with females losing more than males (P<0.001). The pattern was similar, but attenuated in the spine. Subjects undergoing primary cemented TKA had significant bone loss in the hip within 12 months, beyond that expected with age.
authors.affiliation: Department of Physical Therapy, University of Alberta; 2-50 Corbett Hall, Edmonton, AB, Canada.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Beaupre
authors.affiliation: Department of Surgery, Division of Orthopaedic Surgery, University of Alberta, Edmonton, AB, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: Rezansoff
authors.affiliation: Department of Surgery, Division of Orthopaedic Surgery, University of Alberta, Edmonton, AB, Canada.
authors.forename: Marcia
authors.initials: M
authors.lastname: Clark
authors.affiliation: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
authors.forename: Ho
authors.initials: H
authors.lastname: Jen
authors.affiliation: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Lambert
authors.affiliation: Department of Medicine, Division of Internal Medicine, University of Alberta, Edmonton, AB, Canada.
authors.forename: Sumit
authors.initials: S
authors.lastname: Majumdar
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D015519:Bone Density; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010384:Pelvic Bones / Q000000981:diagnostic imaging; D011446:Prospective Studies; D011859:Radiography; D013131:Spine
keywords: bone mineral density; fracture risk; osteoporosis; risk adjustment; total knee arthroplasty