title: Simultaneous estimation of parameters in the bivariate Emax model.
abstract: In this paper, we explore inference in multi-response, nonlinear models. By multi-response, we mean models with m > 1 response variables and accordingly m relations. Each parameter/explanatory variable may appear in one or more of the relations. We study a system estimation approach for simultaneous computation and inference of the model and (co)variance parameters. For illustration, we fit a bivariate Emax model to diabetes dose-response data. Further, the bivariate Emax model is used in a simulation study that compares the system estimation approach to equation-by-equation estimation. We conclude that overall, the system estimation approach performs better for the bivariate Emax model when there are dependencies among relations. The stronger the dependencies, the more we gain in precision by using system estimation rather than equation-by-equation estimation.
authors.affiliation: Statistiska Institutionen, Stockholms Universitet, Stockholm, SE-10691, Sweden.
authors.forename: Bergrun T
authors.initials: BT
authors.lastname: Magnusdottir
authors.affiliation: Statistiska Institutionen, Stockholms Universitet, Stockholm, SE-10691, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Nyquist
mesh_terms: D015982:Bias; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D015233:Models, Statistical; D017711:Nonlinear Dynamics
keywords: Emax model; clinical trials; multi-response nonlinear models; system estimation