title: Perceived Fatigue Interference and Depressed Mood: Comparison of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Fatigued Breast Cancer Survivors.
abstract: OBJECTIVE
  Persistent fatigue and depressive symptoms are both highly prevalent among patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) as well as breast cancer survivors. This study aimed to assess and directly compare perceptions of fatigue as highly interfering in one's daily functioning in both patient populations to better understand their relationships with depressed mood.
  
  
  METHODS
  Participants were 95 female CFS/ME patients and 67 females who were approximately 5 years post-treatment for stage 0-III breast cancer presenting with clinically elevated fatigue severity. Self-report measures were obtained on participants' fatigue-related interference in daily functioning and fatigue severity as well as depressed mood. Hierarchical regression was used to test effects controlling for relevant demographic, psychosocial, and medical covariates.
  
  
  RESULTS
  CFS/ME patients endorsed greater depressed mood and fatigue interference than did fatigued breast cancer survivors,p's<.001. These factors were significantly positively correlated among CFS/ME patients (β=.36,p<.001), but not the fatigued breast cancer survivors (β=.18,p=.19).
  
  
  CONCLUSIONS
  CFS/ME patients reported elevated fatigue symptoms and depression relative to fatigued breast cancer survivors. In the former group, greater depressed mood was highly and significantly associated with greater fatigue-related inference in daily activities. Potential targets for cognitive behavioral interventions are discussed.
authors.affiliation: Department of Psychology, University of Miami.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Hall
authors.affiliation: Department of Psychology, University of Miami ; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine ; Department of Psychiatry and Behavioral Sciences, University of Miami.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Antoni
authors.affiliation: Department of Psychology, University of Miami.
authors.forename: Emily G
authors.initials: EG
authors.lastname: Lattie
authors.affiliation: Department of Psychology, University of Miami.
authors.forename: Devika R
authors.initials: DR
authors.lastname: Jutagir
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Miami.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Czaja
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Miami.
authors.forename: Dolores
authors.initials: D
authors.lastname: Perdomo
authors.affiliation: Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine.
authors.forename: Suzanne C
authors.initials: SC
authors.lastname: Lechner
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School.
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Stagl
authors.affiliation: Department of Psychology, University of Miami.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Bouchard
authors.affiliation: Department of Psychology, University of Miami.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Gudenkauf
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School.
authors.forename: Lara
authors.initials: L
authors.lastname: Traeger
authors.affiliation: Institute for Neuro Immune Medicine, Nova Southeastern University.
authors.forename: MaryAnn
authors.initials: M
authors.lastname: Fletcher
authors.affiliation: Institute for Neuro Immune Medicine, Nova Southeastern University.
authors.forename: Nancy G
authors.initials: NG
authors.lastname: Klimas
keywords: Breast Cancer; Chronic Fatigue Syndrome; Depression; Fatigue