title: Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring.
abstract: Intrauterine growth restriction (IUGR) is associated with an increased risk of developing obesity, insulin resistance and cardiovascular disease. However, its effect on energetics in heart remains unknown. In the present study, we examined respiration in cardiac muscle and liver from adult mice that were undernourished in utero. We report that in utero undernutrition is associated with impaired cardiac muscle energetics, including decreased fatty acid oxidative capacity, decreased maximum oxidative phosphorylation rate and decreased proton leak respiration. No differences in oxidative characteristics were detected in liver. We also measured plasma acylcarnitine levels and found that short-chain acylcarnitines are increased with in utero undernutrition. Results reveal the negative impact of suboptimal maternal nutrition on adult offspring cardiac energy metabolism, which may have life-long implications for cardiovascular function and disease risk.
authors.affiliation: Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
authors.forename: Brittany
authors.initials: B
authors.lastname: Beauchamp
authors.affiliation: Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
authors.forename: A Brianne
authors.initials: AB
authors.lastname: Thrush
authors.affiliation: Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
authors.forename: Jessica
authors.initials: J
authors.lastname: Quizi
authors.affiliation: Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
authors.forename: Ghadi
authors.initials: G
authors.lastname: Antoun
authors.affiliation: Newborn Screening Ontario, Children's Hospital of Eastern Ontario, Ottawa, Ontario K1H 8M8, Canada.
authors.forename: Nathan
authors.initials: N
authors.lastname: McIntosh
authors.affiliation: Newborn Screening Ontario, Children's Hospital of Eastern Ontario, Ottawa, Ontario K1H 8M8, Canada Department of Pediatrics, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.
authors.forename: Osama Y
authors.initials: OY
authors.lastname: Al-Dirbashi
authors.affiliation: Division of Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA 02215, U.S.A.
authors.forename: Mary-Elizabeth
authors.initials: ME
authors.lastname: Patti
authors.affiliation: Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada mharper@uottawa.ca.
authors.forename: Mary-Ellen
authors.initials: ME
authors.lastname: Harper
mesh_terms: D000818:Animals; D001724:Birth Weight; D002331:Carnitine / Q000031:analogs & derivatives / Q000097:blood; D004734:Energy Metabolism; D005260:Female; D006321:Heart / Q000503:physiopathology*; D008099:Liver / Q000378:metabolism; D044342:Malnutrition / Q000150:complications*; D008813:Mice, Inbred ICR; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena
chemical_list: C116917:acylcarnitine; D002331:Carnitine
keywords: energetics; fetal programming; heart; metabolism; mitochondria; obesity