title: Transforming growth factor β type II receptor as a marker in diffuse large B cell lymphoma.
abstract: The objective of this study was to investigate the expression and significance of the transforming growth factor β type II receptor (TGFβRII) in diffuse large B cell lymphoma. All patients were enrolled at the First Affiliated Hospital of Liaoning Medical University between 2001 and 2007. The median follow-up period was 53.3 months. Of the 338 patients studied, 131 (38.76 %) had TGFβRII positive expression on immunohistochemistry. The 5 year survival rate was significantly higher in patients with TGFβRII expression than in those without TGFβRII expression (40.3 vs. 31.6 %, P = 0.041). Multivariate analysis identified TGFβRII expression as an independent predictive parameter for survival, in addition to lactate dehydrogenase, clinical stage, and histologic subtype. TGFβRII expression may be considered a new prognostic factor of diffuse large B cell lymphoma.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, China.
authors.forename: Shudan
authors.initials: S
authors.lastname: Mao
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, China.
authors.forename: Wenqi
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, China.
authors.forename: Limei
authors.initials: L
authors.lastname: Ai
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, China. yincailove@126.com.
authors.forename: Jieping
authors.initials: J
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis* / Q000235:genetics; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D015398:Signal Transduction; D016019:Survival Analysis; D016212:Transforming Growth Factor beta / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II
keywords: Diffuse large B cell lymphoma; Survival; TGFβRII