title: Two novel high performing composite PMMA-CaP cements for vertebroplasty: An ex vivo animal study.
abstract: There is a growing body of the literature on new cement formulations that address the shortcomings of PMMA bone cements approved for use in vertebroplasty (VP) and balloon kyphoplasty (BKP). The present study is a contribution to these efforts by further characterization of two pre-mixed CaP filler-reinforced PMMA bone cements intended for VP; namely, PMMA-HA and PMMA-brushite cements. Each of these cements showed acceptable levels of various properties determined in porcine vertebral bodies. These properties included radiographic contrast, maximum exotherm temperature setting time, cement extravasation, stiffness change after fatigue loading, change of VB height after fracture following fatigue loading, and interdigitation. Each property value was comparable to or better than that for a PMMA bone cement approved for use in BKP. Thus, the results for the composite bone cements are promising.
authors.affiliation: Biomaterials for Osseointegration and Novel Engineering Laboratory (BONE Lab), Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, United States. Electronic address: sxa117530@utdallas.edu.
authors.forename: Shant
authors.initials: S
authors.lastname: Aghyarian
authors.affiliation: Scoliosis & Spine Tumor Center, Texas Back Institute, Texas Health Plano Hospital, Plano, TX 75093, United States.
authors.forename: Xiaobang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Scoliosis & Spine Tumor Center, Texas Back Institute, Texas Health Plano Hospital, Plano, TX 75093, United States.
authors.forename: Isador H
authors.initials: IH
authors.lastname: Lieberman
authors.affiliation: Department of Orthopedic Surgery, University of North Texas Health Science Center (UNTHSC), Fort Worth, TX 76107, United States; Department of Materials Science and Engineering, University of North Texas, Denton, TX 76203, United States.
authors.forename: Victor
authors.initials: V
authors.lastname: Kosmopoulos
authors.affiliation: Center of Excellence in Hip Disorders, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, United States; Department of Orthopedic Surgery, UT Southwestern Medical Center, Dallas, TX 75390, United States.
authors.forename: Harry K W
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Biomaterials for Osseointegration and Novel Engineering Laboratory (BONE Lab), Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, United States.
authors.forename: Danieli C
authors.initials: DC
authors.lastname: Rodrigues
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology; D055595:Mechanical Phenomena; D019904:Polymethyl Methacrylate / Q000737:chemistry* / Q000494:pharmacology; D016062:Porosity; D013552:Swine; D054854:Vertebroplasty / Q000379:methods*
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate
keywords: Augmentation; Biomechanics; Composite bone cement; Osseointegration; Vertebroplasty