title: Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction.
abstract: Dronedarone has been demonstrated to be harmful in patients with recent decompensated heart failure. Furthermore, a PALLAS study reported that dronedarone therapy increases mortality rates in patients with permanent atrial fibrillation. Although a pathophysiological explanation for these finding remains to be elucidated, the long term effects of dronedarone on myocardial structure and stability have been suggested. The aim of the present study was to determine whether dronedarone therapy affects left ventricular (LV) function in a chronic model of myocardial infarction (MI). An anterior MI was induced in 16 pigs. Of these animals, eight pigs were then treated with dronedarone for 1 week prior to, and 4 weeks following MI, the remaining pigs served as controls. LV angiography was performed 4 weeks after MI to determine the LV ejection fraction (LVEF). A post‑mortem magnetic resonance imaging scan of the LV was then performed on the two groups (n=6) to determine the volume and size of the induced MI. Dronedarone therapy did not affect systemic and intracardiac hemodynamic parameters or LVEF during the follow‑up assessment. Of note, dronedarone had no negative effect on the total infarct volume and size and did not induce lethal proarrhythmic effects following the induced anterior MI. Therefore, the results suggested that dronedarone did not increase the volume or size of induced anterior MI and did not affect LV performance. Thus, dronedarone therapy was observed to be safe in a porcine model of anterior MI.
authors.affiliation: Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Ernst‑Moritz‑Arndt‑University, Greifswald D‑17487, Germany.
authors.forename: Josefine
authors.initials: J
authors.lastname: Linke
authors.affiliation: Institute of Pathology, University Medicine Greifswald, Ernst‑Moritz‑Arndt‑University, Greifswald D‑17487, Germany.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Utpatel
authors.affiliation: Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Ernst‑Moritz‑Arndt‑University, Greifswald D‑17487, Germany.
authors.forename: Carmen
authors.initials: C
authors.lastname: Wolke
authors.affiliation: Institute of Pathology, University Medicine Greifswald, Ernst‑Moritz‑Arndt‑University, Greifswald D‑17487, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Evert
authors.affiliation: Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Ernst‑Moritz‑Arndt‑University, Greifswald D‑17487, Germany.
authors.forename: Jens-Peter
authors.initials: JP
authors.lastname: Kühn
authors.affiliation: EUTRAF Working Group, Molecular Electrophysiology, University Hospital Magdeburg, Magdeburg D‑39120, Germany.
authors.forename: Alicja
authors.initials: A
authors.lastname: Bukowska
authors.affiliation: EUTRAF Working Group, Molecular Electrophysiology, University Hospital Magdeburg, Magdeburg D‑39120, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Goette
authors.affiliation: Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Ernst‑Moritz‑Arndt‑University, Greifswald D‑17487, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Lendeckel
authors.affiliation: Institute of Physiology, University Medicine Greifswald, Ernst‑Moritz‑Arndt‑University, Karlsburg D‑17495, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Peters
mesh_terms: D000638:Amiodarone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000494:pharmacology*; D015415:Biomarkers; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D000077764:Dronedarone; D004562:Electrocardiography; D006439:Hemodynamics; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D013552:Swine; D016277:Ventricular Function, Left
chemical_list: D000889:Anti-Arrhythmia Agents; D015415:Biomarkers; D000077764:Dronedarone; D000638:Amiodarone