title: Peptides and Peptidomimetics for Antimicrobial Drug Design.
abstract: The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial properties are presented. A brief discussion of the mechanisms of action of different antimicrobials as well as the development of bacterial resistance towards antimicrobial peptides follows. Finally, current efforts on novel design strategies and peptidomimetics are introduced to illustrate the importance of antimicrobial peptide research in the development of future antibiotics.
authors.affiliation: Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, Postboks 260, Roskilde 4000, Denmark.
authors.forename: Biljana
authors.initials: B
authors.lastname: Mojsoska
authors.affiliation: Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, Postboks 260, Roskilde 4000, Denmark. jenssen@ruc.dk.
authors.forename: Håvard
authors.initials: H
authors.lastname: Jenssen
keywords: antimicrobial peptides; mechanism of action; peptidomimetics