title: Analysis of liver fragment subjected to autologous transplant at rat's retroperitoneum.
abstract: BACKGROUND
  To investigate the regeneration process of autologous implants of liver on the retroperitoneum.
  
  
  METHODS
  Thirty male Fisher rats were used divided in to group 1 (G1): studied 60 d after surgery; group 2 (G2): studied 90 d after surgery; group 3 (G3): studied 180 d after surgery; and group C (GC): animals without surgery. Hepatic fragment was processed for histologic and biochemical analysis.
  
  
  RESULTS
  There was inflammatory infiltrate, diffuse hydropic degeneration, necrosis, and moderate fibrosis that reduced in direct relation to the postsurgical time. The concentration of albumin was different between GC and G1 and between G1 and G3 (P = 0.0007). The Catalase (CAT) was related to the time of surgery with GC being different when compared with G1, G2, and G3 (P < 0.0001). The oxidative stress measured through the thiobarbituric acid reactive substances lipid peroxidation was different between the GC and the G2 groups (P = 0.0381).
  
  
  CONCLUSIONS
  The analysis made showed hepatic regeneration in the fragment subjected to autologous transplant at the retroperitoneum.
authors.affiliation: School of Medicine, Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil.
authors.forename: Mirla Fiuza
authors.initials: MF
authors.lastname: Diniz
authors.affiliation: School of Medicine, Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil. Electronic address: saviolanasiqueira@gmail.com.
authors.forename: Sávio Lana
authors.initials: SL
authors.lastname: Siqueira
authors.affiliation: School of Medicine, Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil.
authors.forename: Tiago Soares
authors.initials: TS
authors.lastname: Baumfeld
authors.affiliation: School of Medicine, Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil.
authors.forename: Luis Felipe Cintra
authors.initials: LF
authors.lastname: Pereira
authors.affiliation: School of Medicine, Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil.
authors.forename: Filipe Garcia
authors.initials: FG
authors.lastname: Moreira
authors.affiliation: School of Medicine, Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil.
authors.forename: Gustavo Meirelles
authors.initials: GM
authors.lastname: Ribeiro
authors.affiliation: School of Medicine, Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil.
authors.forename: Iure Kalinine Ferraz
authors.initials: IK
authors.lastname: de Souza
mesh_terms: D000818:Animals; D064592:Autografts; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008115:Liver Regeneration; D016031:Liver Transplantation; D008297:Male; D051381:Rats; D012187:Retroperitoneal Space
keywords: Autotransplantation; Experimental surgery; Hepatic regeneration