title: Impact of monitoring longitudinal systolic strain changes during serial echocardiography on outcome in patients with AL amyloidosis.
abstract: Relative apical sparing of longitudinal systolic strain (LSsys) with preserved LSsys at apical and significantly reduced LSsys at mid/basal segments is a typical echocardiographic feature in AL amyloidosis patients with cardiac involvement. The present study aims to evaluate the change of this typical feature over time by serial echocardiography and its impact on outcome in AL amyloidosis patients with cardiac involvement. Echocardiography was performed in 24 consecutive patients with biopsy-proven AL amyloidosis (mean age 64 ± 9 years; 50% male) at baseline and during a median of 257 (quartiles 103-651) days follow-up. Global and segmental LSsys were assessed by two-dimensional speckle-tracking-imaging in septal and lateral segments of the left ventricle (LV) from the apical 4-chamber view. Sixteen (67%) patients died during a median follow-up of 487 days (quartiles 223-872). LV global and segmental LSsys remained unchanged over time in survivors (all P > 0.05), while LV global, septal-apical and lateral-apical LSsys significantly decreased in non-survivors. A decrease in lateral-apical LSsys > 3.0% independently predicted a fivefold increased all-cause mortality risk after adjustment for age, gender, NYHA class, and treatment strategies. Further, baseline serum NT-proBNP, serum albumin decrease during follow-up, baseline septal apical-to-basal LSsys ratio and lateral-apical LSsys decrease during follow-up remained independently predictive of increased all-cause mortality risk. Serial monitoring of serological and echocardiographic parameters is valuable to predict outcome in AL amyloidosis patients with cardiac involvement. The best follow-up parameter to predict risk for imminent death is a decrease of longitudinal systolic strain at the lateral apical segment.
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany. Hu_K@ukw.de.|Comprehensive Heart Failure Center, Würzburg, Germany. Hu_K@ukw.de.
authors.forename: Kai
authors.initials: K
authors.lastname: Hu
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.|Comprehensive Heart Failure Center, Würzburg, Germany.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.|Comprehensive Heart Failure Center, Würzburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Nordbeck
authors.affiliation: Department for Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Maja
authors.initials: M
authors.lastname: Cikes
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.|Comprehensive Heart Failure Center, Würzburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Störk
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.|Comprehensive Heart Failure Center, Würzburg, Germany.
authors.forename: Bastian
authors.initials: B
authors.lastname: Kramer
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.|Comprehensive Heart Failure Center, Würzburg, Germany.
authors.forename: Philipp Daniel
authors.initials: PD
authors.lastname: Gaudron
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schneider
authors.affiliation: Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Knop
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.|Comprehensive Heart Failure Center, Würzburg, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Ertl
authors.affiliation: ICREA - Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Bart
authors.initials: B
authors.lastname: Bijnens
authors.affiliation: Comprehensive Heart Failure Center, Würzburg, Germany.|Katharinen-Hospital Unna, Unna, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Weidemann
authors.affiliation: Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.|Comprehensive Heart Failure Center, Würzburg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Herrmann
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D000075363:Immunoglobulin Light-chain Amyloidosis; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D013314:Stress, Mechanical; D013599:Systole; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016277:Ventricular Function, Left
keywords: Left ventricular strain; Prognosis; Speckle tracking; Systemic amyloidosis