title: Lagos bat virus transmission in an Eidolon helvum bat colony, Ghana.
abstract: A brain sample of a straw-coloured fruit bat (Eidolon helvum) from Ghana without evident signs of disease tested positive by generic Lyssavirus RT-PCR and direct antigen staining. Sequence analysis confirmed the presence of a Lagos bat virus belonging to phylogenetic lineage A. Virus neutralization tests using the isolate with sera from the same group of bats yielded neutralizing antibodies in 74% of 567 animals. No cross-neutralization was observed against a different Lagos bat virus (lineage B).
authors.affiliation: Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Molecular Virology and Cell Biology, WHO Collaborating Centre for Rabies Surveillance and Research, Greifswald-Insel Riems, Germany. Electronic address: Conrad.Freuling@fli.bund.de.
authors.forename: Conrad M
authors.initials: CM
authors.lastname: Freuling
authors.affiliation: Institute of Virology, University of Bonn and German Centre for Infection Research, Bonn, Germany.
authors.forename: Tabea
authors.initials: T
authors.lastname: Binger
authors.affiliation: Friedrich-Loeffler-Institut, Institute of Diagnostic Virology, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Beer
authors.affiliation: Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Yaw
authors.initials: Y
authors.lastname: Adu-Sarkodie
authors.affiliation: Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Molecular Virology and Cell Biology, WHO Collaborating Centre for Rabies Surveillance and Research, Greifswald-Insel Riems, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Schatz
authors.affiliation: Friedrich-Loeffler-Institut, Institute of Diagnostic Virology, Germany.
authors.forename: Melina
authors.initials: M
authors.lastname: Fischer
authors.affiliation: Friedrich-Loeffler-Institut, Institute of Diagnostic Virology, Germany.
authors.forename: Dennis
authors.initials: D
authors.lastname: Hanke
authors.affiliation: Friedrich-Loeffler-Institut, Institute of Diagnostic Virology, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Hoffmann
authors.affiliation: Friedrich-Loeffler-Institut, Institute of Diagnostic Virology, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Höper
authors.affiliation: Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Molecular Virology and Cell Biology, WHO Collaborating Centre for Rabies Surveillance and Research, Greifswald-Insel Riems, Germany.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Mettenleiter
authors.affiliation: Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Samual K
authors.initials: SK
authors.lastname: Oppong
authors.affiliation: Institute of Virology, University of Bonn and German Centre for Infection Research, Bonn, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Drosten
authors.affiliation: Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Molecular Virology and Cell Biology, WHO Collaborating Centre for Rabies Surveillance and Research, Greifswald-Insel Riems, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D002685:Chiroptera / Q000821:virology*; D018562:Disease Transmission, Infectious; D005869:Ghana / Q000453:epidemiology; D018114:Lyssavirus / Q000145:classification / Q000302:isolation & purification*; D018353:Rhabdoviridae Infections / Q000635:transmission / Q000662:veterinary*; D016036:Seroepidemiologic Studies
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: Bat rabies; Full genome sequencing; Lagos bat lyssavirus; Lyssaviruses; Pan-lyssa realtime PCR; Serological survey