title: Rabovirus: a proposed new picornavirus genus that is phylogenetically basal to enteroviruses and sapeloviruses.
abstract: We have sequenced the genome of a novel picornavirus, rabovirus A (rat-borne virus, RaBoV-A, NC_026314), which was present in the feces of a Norway rat (Rattus norvegicus) from Berlin, Germany. This virus is related to members of the genera Enterovirus and Sapelovirus. RaboV-A contains a type II IRES that is unlike the type I IRES elements of enteroviruses and the type IV elements of sapeloviruses. Its genome is marked by an L protein and a chymotrypsin-like 2A protease. Our analysis of genome organization, pairwise identities, motif, phylogenic and UTR (GIMPU) indicates that RaBoV-A potentially represents a new picornavirus genus, for which we propose the name "Rabovirus". Spread by their rodent hosts and detected in New York and Berlin rats, these viruses may have a wide geographic distribution.
authors.affiliation: Blood Systems Research Institute, San Francisco, CA, USA. terryfeifan@gmail.com.|Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA. terryfeifan@gmail.com.|DVD, NCIRD, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA, 30333, USA. terryfeifan@gmail.com.
authors.forename: Terry Fei Fan
authors.identifier: http://orcid.org/0000-0002-4815-8697
authors.initials: TF
authors.lastname: Ng
authors.affiliation: Blood Systems Research Institute, San Francisco, CA, USA.|Federal Institute for Risk Assessment, Berlin, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Sachsenröder
authors.affiliation: Regional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Reuter
authors.affiliation: The Pirbright Institute, Woking, Surrey, UK.
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Knowles
authors.affiliation: Blood Systems Research Institute, San Francisco, CA, USA.|Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Delwart
authors.affiliation: Federal Institute for Risk Assessment, Berlin, Germany.
authors.forename: Reimar
authors.initials: R
authors.lastname: Johne
mesh_terms: D000818:Animals; D001483:Base Sequence; D004770:Enterovirus / Q000145:classification / Q000235:genetics*; D016679:Genome, Viral; D005858:Germany; D008969:Molecular Sequence Data; D010802:Phylogeny; D010849:Picornaviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000662:veterinary* / Q000821:virology; D051381:Rats; D012376:Rodent Diseases / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins