title: Two new alkaloids from Melodinus hemsleyanus Diels.
abstract: Two new monoterpenoid indole alkaloids, named 14,15-dihydro-14β,15β-epoxy-10-hydroxyscandine (1) and 15α-hydroxy-meloscandonine (2), together with 12 known compounds, were isolated from the aerial parts of Melodinus hemsleyanus Diels. The structures of 1 and 2 were elucidated on the bases of 1D and 2D NMR spectra and MS. Two new compounds were evaluated for their PTP1B and Drak2 inhibitory effects, and inactivity.
authors.affiliation: a Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 , P.R. China.|b Key Laboratory of Modern Preparation of TCM, Ministry of Education , Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , P.R. China.
authors.forename: Pu-Zhao
authors.initials: PZ
authors.lastname: Zhang
authors.affiliation: b Key Laboratory of Modern Preparation of TCM, Ministry of Education , Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , P.R. China.
authors.forename: Ya-Mei
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: a Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 , P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gu
authors.affiliation: a Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 , P.R. China.
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Zhang
mesh_terms: D029062:Apocynaceae / Q000737:chemistry*; D051017:Apoptosis Regulatory Proteins / Q000037:antagonists & inhibitors; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C000609497:14,15-dihydro-14beta,15beta-epoxy-10-hydroxyscandine; C000609499:15alpha-hydroxy-meloscandonine; D051017:Apoptosis Regulatory Proteins; D004365:Drugs, Chinese Herbal; D047428:Protein Kinase Inhibitors; D046948:Secologanin Tryptamine Alkaloids; D017346:Protein Serine-Threonine Kinases; C115489:STK17B protein, human; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Apocynaceae; Melodinus; alkaloid