title: [Cutaneous chondroid syringoma].
abstract: BACKGROUND
  Chondroid syringoma (CS) is a rare cutaneous tumor characterized by mixte epithelial and mesenchymal component. The confident histological diagnosis can be obtained by immuno-histochemistry study. Here we present 10 new cases with their clinico-hystological characteristics.
  
  
  METHODS
  The 10 cases were observed between January 2000 and august 2013, in Fort-de-France and Louis-Mourier universitary hospitals. For all the cases a controlled histological study was performed by a dermatopathologist expert and immuno-histochemistry was added. Clinical and immuno-histological data were analyzed.
  
  
  RESULTS
  The lesions were almost localized on the face (3/10) and the extremities (3/10). The size was about 1.2 to 5.2cm. Every case was treated by surgery, no malignant case was diagnosed. Histologically, all the 10 cases presented as a well-limited dermic tumor with a mixte epithelial and mesenchymal component. The stroma was myxo-chondroid, and the epithelial component consisted in epithelial cavities lined by one or two cell layers with eccrine (4/10) or apocrine (5/10) features. Immuno-chemistry study reveals positivity for EMA, ACE and CK7 for the internal cells, and positivity for S100 protein and vimentin of the extern cell layer.
  
  
  CONCLUSIONS
  Chondroid syringoma is characterized by a mixte epithelial with eccrine and apocrine cells and a myxo-chondroid stroma. Our study has some clinical and histological particularities (lesions on the extremities, epidermic connecting…). The main differentials diagnoses are the other annexial tumors. The treatment is surgical.
  
  
  CONCLUSIONS
  The histological diagnosis of CS is quite easy, but in case of doubt, immuno-chemistry will help, showing a double mesenchymal and epithelial differentiation.
authors.affiliation: Service de pathologie, hôpital Pierre-Zobda-Quitman, CHU de Fort-de-France, CS 90632, 97261 Fort-de-France, Martinique; Service de dermatologie, hôpital Pierre-Zobda-Quitman CHU de Fort-de-France, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: Agathe
authors.initials: A
authors.lastname: Aoun
authors.affiliation: Service de pathologie, hôpital Pierre-Zobda-Quitman, CHU de Fort-de-France, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: Leila
authors.initials: L
authors.lastname: Dufrenot-Petitjean-Roget
authors.affiliation: Service de dermatologie, hôpital Pierre-Zobda-Quitman CHU de Fort-de-France, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Amazan
authors.affiliation: Service de dermatologie, hôpital Pierre-Zobda-Quitman CHU de Fort-de-France, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: Christian
authors.initials: C
authors.lastname: Derancourt
authors.affiliation: Service de dermatologie, CHU Avicenne, 125, rue de Stalingrad, 93000 Bobigny, France.
authors.forename: Marina
authors.initials: M
authors.lastname: Alexandre
authors.affiliation: Service de dermatologie, hôpital Pierre-Zobda-Quitman CHU de Fort-de-France, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: Danièle
authors.initials: D
authors.lastname: Quist
authors.affiliation: Service de pathologie, CHU Louis-Mourier, 178, rue des Renouillers, 92700 Colombes, France.
authors.forename: Maggy
authors.initials: M
authors.lastname: Grossin
authors.affiliation: Service de pathologie, hôpital Pierre-Zobda-Quitman, CHU de Fort-de-France, CS 90632, 97261 Fort-de-France, Martinique. Electronic address: vincent.molinie@chu-fortdefrance.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Molinié
mesh_terms: D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001050:Apocrine Glands / Q000473:pathology; D014408:Biomarkers, Tumor; D004439:Eccrine Glands / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005121:Extremities / Q000473:pathology; D005153:Facial Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D053552:Keratin-7 / Q000032:analysis; D008297:Male; D008648:Mesoderm / Q000473:pathology; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D017154:Stromal Cells / Q000473:pathology; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D053552:Keratin-7; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin
keywords: Apocrine; Chondroid syringoma; Cutaneous anexial tumor; Eccrine; Exocrine; Immuno-histochemistry; Immuno-histochimie; Syringome chondroïde; Tumeur annexielle cutanée