title: 68Ga-Based radiopharmaceuticals: production and application relationship.
abstract: The contribution of 68Ga to the promotion and expansion of clinical research and routine positron emission tomography (PET) for earlier better diagnostics and individualized medicine is considerable. The potential applications of 68Ga-comprising imaging agents include targeted, pre-targeted and non-targeted imaging. This review discusses the key aspects of the production of 68Ga and 68Ga-based radiopharmaceuticals in the light of the impact of regulatory requirements and endpoint pre-clinical and clinical applications.
authors.affiliation: Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala SE-751 85, Sweden. irina.velikyan@akademiska.se.|PET Center, Center for Medical Imaging, Uppsala University Hospital, Uppsala SE-751 85, Sweden . irina.velikyan@akademiska.se.
authors.forename: Irina
authors.initials: I
authors.lastname: Velikyan
mesh_terms: D005708:Gallium / Q000737:chemistry*; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D005708:Gallium
keywords: 68Ga; GMP; chemistry; dosimetry; peptide; positron emission tomography; receptor targeting