title: Francisella tularensis aortitis.
abstract: Francisella tularensis, the agent of tularemia, is a Gram-negative coccobacillus primarily pathogen for animals and occasionally for humans. The clinical manifestations of tularemia include pneumonia, ulceroglandular, oropharyngeal, or typhoidal disease. Rare manifestations are also described, but to our knowledge, we describe here the first case of F. tularensis aortitis in a human. Diagnosis was confirmed by the presence of F. tularensis in blood culture, by the presence of F. tularensis DNA in the aortic biopsy and by specific IgG and IgM responses against the bacteria. The outcome was favorable after surgery and specific antimicrobial therapy.
authors.affiliation: Department of Infectious Diseases, CHU Nantes, Nantes, France. magalibriere1979@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Briere
authors.affiliation: Department of Vascular Surgery, CHU Nantes, Nantes, France.
authors.forename: A
authors.initials: A
authors.lastname: Kaladji
authors.affiliation: Department of Radiology, CHU Nantes, Nantes, France.
authors.forename: F
authors.initials: F
authors.lastname: Douane
authors.affiliation: Department of Medicine and Infectious Diseases, CH Cholet, Cholet, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Breux
authors.affiliation: Department of Microbiology, CH Cholet, Cholet, France.
authors.forename: P
authors.initials: P
authors.lastname: Touroult-Jupin
authors.affiliation: National Reference Center for Francisella, CHU Grenoble, Grenoble, France.
authors.forename: S
authors.initials: S
authors.lastname: Boisset
authors.affiliation: National Reference Center for Rickettsiosis and Francisella tularensis, Institut Hospital-Universitaire Méditerranée-Infection, Aix-Marseille Université, Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Edouard
authors.affiliation: Department of Infectious Diseases, CHU Nantes, Nantes, France.
authors.forename: C
authors.initials: C
authors.lastname: Biron
authors.affiliation: Department of Infectious Diseases, CHU Nantes, Nantes, France.
authors.forename: D
authors.initials: D
authors.lastname: Boutoille
mesh_terms: D000369:Aged, 80 and over; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D001011:Aorta / Q000473:pathology; D001025:Aortitis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D001706:Biopsy; D001769:Blood / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D003646:Debridement; D005604:Francisella tularensis / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D016896:Treatment Outcome; D014406:Tularemia / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: Aortitis; Atherosclerosis; Bacteremia; Infrequent presentation; Tularemia