title: Endoscopic submucosal dissection for the treatment of large gastric submucosal tumors originating from the muscularis propria layer: a single center study.
abstract: OBJECTIVE
  This retrospective study was designed to evaluate the safety and efficacy of endoscopic submucosal dissection (ESD) for the resection of gastric submucosal tumors (SMTs) originating from the muscularis propria (MP) layer at our institution.
  
  
  METHODS
  From January 2010 to January 2014, a total of 49 patients underwent ESD for the resection of MP-originating gastric SMTs. The characteristics of the 49patients, clinical efficacy, safety of ESD, and post-ESD pathological diagnoses were evaluated retrospectively.
  
  
  RESULTS
  ESD was successfully performed in 48 cases, and one case was converted to surgery. Pathological diagnosis included 43 gastrointestinal stromal tumors, 5 leiomyomas, and 1 schwannoma. During the procedure, 9 patients developed perforation. These patients recovered after conservative treatment. No residual or recurrent tumors were detected during the follow-up period.
  
  
  CONCLUSIONS
  ESD seems to be a feasible, safe, effective and minimally invasive procedure, even for the resection of large gastric tumors originating from the MP. However, more studies should be carried out in the future.
authors.affiliation: Gastroenterology, First Affiliated Hospital of ZheJiang University, Hangzhou, China.
authors.forename: F S
authors.initials: FS
authors.lastname: Meng
authors.affiliation: Hematological lab, People's hospital of Linyi, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Zhang
authors.affiliation: Gastroenterology, First Affiliated Hospital of ZheJiang University, Hangzhou, China.
authors.forename: G D
authors.initials: GD
authors.lastname: Shan
authors.affiliation: Gastroenterology, First Affiliated Hospital of ZheJiang University, Hangzhou, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Gastroenterology, First Affiliated Hospital of ZheJiang University, Hangzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D004210:Dissection / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology* / Q000601:surgery*; D005773:Gastroscopy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome