title: Deep hypothermia for the treatment of refractory status epilepticus.
abstract: In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20 °C for 30 min) reduced EEG power over 50-fold, stopped SE within 12 min, and reduced EEG spikes by 87%. Hypothermia deserves further investigation as a treatment of last resort for refractory SE. This article is part of a Special Issue entitled "Status Epilepticus".
authors.affiliation: Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA. Electronic address: jniquet@ucla.edu.
authors.forename: Jerome
authors.initials: J
authors.lastname: Niquet
authors.affiliation: Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Roger
authors.initials: R
authors.lastname: Baldwin
authors.affiliation: Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Gezalian
authors.affiliation: Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Claude G
authors.initials: CG
authors.lastname: Wasterlain
mesh_terms: D000818:Animals; D003292:Convulsants; D000069279:Drug Resistant Epilepsy / Q000139:chemically induced / Q000628:therapy*; D004569:Electroencephalography / Q000187:drug effects; D007036:Hypothermia, Induced / Q000379:methods*; D008094:Lithium; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000628:therapy*
chemical_list: D003292:Convulsants; D010862:Pilocarpine; D008094:Lithium; D008874:Midazolam
keywords: EEG power; Hypothermia; Status epilepticus