title: Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III).
abstract: (5,10,15,20-Tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III) (complex 1) was conjugated to platinum nanoparticles (PtNPs) (represented as 1-PtNPs). The resulting conjugate showed 18 nm red shift in the Soret band when compared to 1 alone. Complex 1 and 1-PtNPs showed promising photodynamic antimicrobial chemotherapy (PACT) activity against Staphylococcus aureus, Escherichia coli and Candida albicans in solution where the log reductions obtained were 4.92, 3.76, and 3.95, respectively for 1-PtNPs. The singlet oxygen quantum yields obtained were higher at 0.56 for 1-PtNPs in DMF while that of 1 was 0.52 in the same solvent. This resulted in improved PACT activity for 1-PtNPs compared to 1 alone.
authors.affiliation: Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa.
authors.forename: Muthumuni
authors.initials: M
authors.lastname: Managa
authors.affiliation: Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa.
authors.forename: Edith K
authors.initials: EK
authors.lastname: Amuhaya
authors.affiliation: Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa. Electronic address: t.nyokong@ru.ac.za.
authors.forename: Tebello
authors.initials: T
authors.lastname: Nyokong
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005708:Gallium / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D008665:Metalloporphyrins / Q000737:chemistry* / Q000494:pharmacology; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers / Q000737:chemistry; D010778:Photochemotherapy / Q000379:methods*; D010984:Platinum / Q000737:chemistry; D026082:Singlet Oxygen; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: C000610351:(5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato)chlorogallium(III); D000890:Anti-Infective Agents; D008665:Metalloporphyrins; D026082:Singlet Oxygen; D010984:Platinum; D005708:Gallium
keywords: Candida albicans; Electrospinning; Escherichia coli; Gallium porphyrin; Photodynamic antimicrobial chemotherapy; Singlet oxygen; Staphylococcus aureus