title: Folate receptor α expression and significance in endometrioid endometrium carcinoma and endometrial hyperplasia.
abstract: Endometrioid-type endometrial carcinoma (EEC) developing on the ground of endometrial hyperplasia (EH) is amongst the most commonly observed type of cancer in the world. Folate receptor α (FRα) is a vitamin molecule that has a role in cell proliferation. The fact that FRα, which is known to be needed extremely by the cells of malignancies that proliferate rapidly, is present in limited amounts in normal tissues while it is overexpressed in malignant cells of the same tissues makes folate a candidate for target molecular therapy. In our study, FRα expression in 214 cases, with 95 diagnosed within EEC and 119 with EH, was studied immunohistochemically. FRα expression in EEC was found significantly high compared to EH and normal endometrium (P<0.01). Similarly, FRα expression in EH cases with complex atypia were significantly high compared to other hyperplasia subgroups (P<0.01). The findings of our results make us think that FRα overexpression may play a role in the EEC carcinogenesis and carcinoma progression from EH. Furthermore, we suggest that it can be helpful in the treatment of EEC and/or transition from hyperplasia stage to EEC as a molecular therapy targeting receptors labeled with antibody-based props containing FRα. Finally, we suggest that FRα may be used, based on the expression intensity, as a supplemental option to determine the patients that shall be directed to radical therapy amongst patients with complex atypical EH.
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Senol
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Turkey.
authors.forename: Ayse Bahar
authors.initials: AB
authors.lastname: Ceyran
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Aydin
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Zemheri
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Turkey.
authors.forename: Seyma
authors.initials: S
authors.lastname: Ozkanli
authors.affiliation: Department of Pathology, Van Bölge Research and Training Hospital Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Kösemetin
authors.affiliation: Department of Pathology, Recep Tayyip Erdogan University, Faculty of Medicine Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sehitoglu
authors.affiliation: Department of Medical Genetics, Istanbul Medeniyet University, Faculty of Medicine Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Akalin
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D018269:Carcinoma, Endometrioid / Q000737:chemistry* / Q000473:pathology; D018450:Disease Progression; D004714:Endometrial Hyperplasia / Q000378:metabolism* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D058975:Folate Receptor 1 / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011237:Predictive Value of Tests; D046888:Tissue Array Analysis; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C548696:FOLR1 protein, human; D058975:Folate Receptor 1
keywords: Endometrial carcinoma; endometrial hyperplasia; folate receptor α; target therapy