title: Effect of fermented milk product containing lactotripeptides and plant sterol esters on haemodynamics in subjects with the metabolic syndrome--a randomised, double-blind, placebo-controlled study.
abstract: We investigated the effects of fermented milk product containing isoleucine-proline-proline, valine-proline-proline and plant sterol esters (Pse) on plasma lipids, blood pressure (BP) and its determinants systemic vascular resistance and cardiac output. In a randomised, double-blind, placebo-controlled study, 104 subjects with the metabolic syndrome (MetS) were allocated to three groups in order to receive fermented milk product containing (1) 5 mg/d lactotripeptides (LTP) and 2 g/d plant sterols; (2) 25 mg/d LTP and 2 g/d plant sterols; (3) placebo for 12 weeks. Plasma lipids and home BP were monitored. Haemodynamics were examined in a laboratory using radial pulse wave analysis and whole-body impedance cardiography in the supine position and during orthostatic challenge. There were no differences between the effects of the two treatments and placebo on the measurements of BP at home or on BP, systemic vascular resistance index and cardiac index in the laboratory, neither in the supine nor in the upright position. The changes in plasma LDL-cholesterol concentration were - 0.1 (95% CI - 0.3, 0.1 and - 0.3, 0.0) mmol/l in the 5 and 25 mg/d LTP groups, respectively, and +0.1 (95% CI - 0.1, 0.3) mmol/l during placebo (P= 0.024). Both at baseline and at week 12, the increase in systemic vascular resistance during head-up tilt was lower in the 25 mg/d LTP group than in the 5 mg/d LTP group (P< 0.01), showing persistent differences in cardiovascular regulation between these groups. In subjects with the MetS, intake of LTP and Pse in fermented milk product showed a lipid-lowering effect of borderline significance, while no antihypertensive effect was observed at home or in the laboratory.
authors.affiliation: School of Medicine, University of Tampere,Tampere,Finland.
authors.forename: Elina J
authors.initials: EJ
authors.lastname: Hautaniemi
authors.affiliation: School of Medicine, University of Tampere,Tampere,Finland.
authors.forename: Antti J
authors.initials: AJ
authors.lastname: Tikkakoski
authors.affiliation: School of Medicine, University of Tampere,Tampere,Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Tahvanainen
authors.affiliation: School of Health Sciences, University of Tampere,Tampere,Finland.
authors.forename: Klaus
authors.initials: K
authors.lastname: Nordhausen
authors.affiliation: School of Medicine, University of Tampere,Tampere,Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.affiliation: Valio Limited, Research and Development,Helsinki,Finland.
authors.forename: Tiina
authors.initials: T
authors.lastname: Mattsson
authors.affiliation: Valio Limited, Research and Development,Helsinki,Finland.
authors.forename: Satu
authors.initials: S
authors.lastname: Luhtala
authors.affiliation: Valio Limited, Research and Development,Helsinki,Finland.
authors.forename: Anu M
authors.initials: AM
authors.lastname: Turpeinen
authors.affiliation: School of Medicine, University of Tampere,Tampere,Finland.
authors.forename: Onni
authors.initials: O
authors.lastname: Niemelä
authors.affiliation: Faculty of Medicine, Department of Pharmacology,University of Helsinki, Helsinki,Finland.
authors.forename: Heikki
authors.initials: H
authors.lastname: Vapaatalo
authors.affiliation: Faculty of Medicine, Department of Pharmacology,University of Helsinki, Helsinki,Finland.
authors.forename: Riitta
authors.initials: R
authors.lastname: Korpela
authors.affiliation: School of Medicine, University of Tampere,Tampere,Finland.
authors.forename: Ilkka H
authors.initials: IH
authors.lastname: Pörsti
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D043302:Cultured Milk Products / Q000737:chemistry*; D004311:Double-Blind Method; D004952:Esters / Q000008:administration & dosage; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D009842:Oligopeptides / Q000008:administration & dosage*; D010840:Phytosterols / Q000008:administration & dosage*; D010919:Placebos; D011187:Posture; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D004952:Esters; D008055:Lipids; D009842:Oligopeptides; D010840:Phytosterols; D010919:Placebos
keywords: Blood pressure; Cholesterol; Lactotripeptides; Plant sterol esters; Systemic vascular resistance index