title: Oxidative Stress and DNA Damage: Implications in Inflammatory Bowel Disease.
abstract: This review will focus on published human studies on oxidative stress and DNA damage in inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease, assessing their role in the pathophysiology of these diseases. Search was performed over PubMed and ScienceDirect databases to identify relevant bibliography, using keywords including "oxidative stress," "DNA damage," "IBD," and "oxidative DNA damage." Whether as cause or effect, mechanisms underlying oxidative stress have the potential to condition the course of various pathologies, particularly those driven by inflammatory scenarios. IBDs are chronic inflammatory relapsing conditions. Oxidative stress has been associated with some of the characteristic clinical features exhibited in IBD, namely tissue injury and fibrosis, and also to the ulcerative colitis-associated colorectal cancer. The possible influence of oxidative stress over therapeutic behavior and response, as well as their contribution to the oxidative burden and consequences, is also addressed. Due to the high prevalence and incidence of IBD worldwide, and also to its associated morbidity, complications, and disease and treatment costs, it is of paramount importance to better understand the pathophysiology of these diseases.
authors.affiliation: *Department of Environmental Health, National Health Institute, Porto, Portugal; †Department of Pharmacology, MedInUP, Center for Drug Discovery and Innovative Medicines, Porto, Portugal; and ‡Unit of Gastroenterology, Hospital São João, Porto, Portugal.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Pereira
authors.forename: Daniela
authors.initials: D
authors.lastname: Grácio
authors.forename: João P
authors.initials: JP
authors.lastname: Teixeira
authors.forename: Fernando
authors.initials: F
authors.lastname: Magro
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000235:genetics / Q000378:metabolism; D003424:Crohn Disease / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants