title: Impairment and Regeneration of Gastric Mucosa After Irradiation in Mice.
abstract: OBJECTIVE
  To understand the effects of γ-ray irradiation (IR) on the proliferation of gastric mucosal cells and to investigate the possible mechanisms that affect gastric mucosal cell proliferation.
  
  
  METHODS
  C57BL/6J mice were exposed to IR at various doses (4, 8, and 15 Gy). We measured the changes of gastric mucosal BrdU-positive cells and the expression of β-catenin protein in the isthmus of fundic glands at days 1, 3, and 5 after irradiation.
  
  
  RESULTS
  Our data showed that the mice that received 15 Gy IR died within 4 days. IR caused gastric mucosal injury in mice, and the degree of injury increased along with the increasing doses. Compared with the control group, the proliferation of gastric mucosal cells was inhibited 1 day after irradiation. Cell proliferation was recovered on day 5 after low-dose (4 and 8 Gy) IR, while proliferation was continuously inhibited after high-dose (15 Gy) IR. β-catenin expression was increased and had a translocation in the isthmus of gastric mucosa.
  
  
  CONCLUSIONS
  These findings suggest that gastric mucosa is sensitive to irradiation. The Wnt/β-catenin pathway is activated and plays a role in cell proliferation of gastric mucosa upon irradiation.
authors.forename: Huihong
authors.initials: H
authors.lastname: Zeng
authors.forename: Jinying
authors.initials: J
authors.lastname: Tong
authors.forename: Jianghong
authors.initials: J
authors.lastname: Zou
authors.forename: Aixiang
authors.initials: A
authors.lastname: Fu
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Shao
authors.forename: Qingxian
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000528:radiation effects*; D005753:Gastric Mucosa / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects