title: Assessment of bone turnover markers and bone mineral density in normal short boys.
abstract: OBJECTIVE
  To investigate whether there is a change in bone turnover-related biochemical markers and bone mineral density of children with constitutional delay of growth and puberty (CDGP) in the prepubertal period.
  
  
  METHODS
  We measured serum calcium, phosphorus, alkaline phosphatase, parathormone, 25-OH vitamin D, osteocalcin, osteoprotogerin and urinary deoxypyridinoline levels (D-pyd), and bone mineral density (BMD) in 31 prepubertal boys with CDGP. These children were compared with 22 prepubertal boys with familial short stature (FSS) and 27 normal prepubertal boys.
  
  
  RESULTS
  Urinary D-pyd was significantly high in CDGP group as compared to control group (p=0.010). Volumetric BMD did not significantly differ between CDGP, FSS, and control groups (p=0.450). Volumetric BMD and urinary D-pyd levels of FSS and control groups were similar. Mean or median levels of calcium, phosphorus, alkaline phosphatase, parathormone, and osteoprotegerin did not significantly differ between CDGP, FSS, and control groups.
  
  
  CONCLUSIONS
  Our data suggest that prepubertal boys with CDPG have normal bone turnover. However, their significantly higher urinary D-pyd levels relative to those of FSS and control groups might be an indicator of later development of osteoporosis. Therefore, long-term follow-up studies monitoring bone mineral status of prepubertal boys with CDPG from prepuberty to adulthood are needed to better understand bone metabolism of these patients.
authors.forename: Zeynep Gökçe
authors.initials: ZG
authors.lastname: Gayretli Aydin
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
authors.forename: Hamdi C
authors.initials: HC
authors.lastname: Emeksiz
authors.forename: Nurullah
authors.initials: N
authors.lastname: Çelik
authors.forename: Esra
authors.initials: E
authors.lastname: Döğer
authors.forename: Neslihan
authors.initials: N
authors.lastname: Bukan
authors.forename: Ummügülsüm
authors.initials: U
authors.lastname: Yildiz
authors.forename: Orhun M
authors.initials: OM
authors.lastname: Camurdan
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001827:Body Height / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D002118:Calcium / Q000097:blood; D002648:Child; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D015675:Osteocalcin / Q000097:blood; D053244:Osteoprotegerin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011628:Puberty, Delayed / Q000097:blood* / Q000000981:diagnostic imaging; D011859:Radiography; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D015675:Osteocalcin; D014807:Vitamin D; D010758:Phosphorus; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D002118:Calcium