title: Reliability and validity of the Cancer Therapy Satisfaction Questionnaire in lung cancer.
abstract: OBJECTIVE
  To test the reliability and validity of the Cancer Treatment Satisfaction Questionnaire (CTSQ), to assess its relation with quality of life (QoL), and to assess the interpretability of the domain scores in lung cancer patients receiving intravenous chemotherapy.
  
  
  METHODS
  Patients with stage IIIB and IV non-squamous non-small cell lung carcinoma treated with pemetrexed were enrolled in our study. They completed the 16-item CTSQ and two other (health-related) QoL questionnaires. Information about sociodemographic characteristics, cancer stage, and the experience of adverse events was collected. Internal consistency, construct validity, and clinical interpretability were calculated.
  
  
  RESULTS
  Fifty-five patients completed the CTSQ. Correlations of the CTSQ items with its domain were all above 0.40. A high correlation between item 8 and the expectations of therapy and satisfaction with therapy domain was observed (0.50 and 0.48, respectively). The CTSQ domains demonstrated good internal consistency and low to moderate correlations of the CTSQ with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 and World Health Organization Quality of Life-BREF. No significant differences in mean domain scores were observed in relation to the number and severity of different adverse events and chemotherapy-related adverse events.
  
  
  CONCLUSIONS
  The Dutch version of the CTSQ was found to be a reliable and valid instrument to assess satisfaction and expectations of treatment in lung cancer patients receiving intravenous chemotherapy. Furthermore, the CTSQ proved to be of additional informative value as not all of its domains correlated with the various domains of the existing HRQoL instruments.
authors.affiliation: Department of Epidemiology, Erasmus MC - University Medical Centre Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. c.cheung@erasmusmc.nl.|Inspectorate of Health Care, The Hague, The Netherlands. c.cheung@erasmusmc.nl.
authors.forename: K
authors.initials: K
authors.lastname: Cheung
authors.affiliation: Department of Pulmonary Diseases, Amphia Hospital Breda, Breda, The Netherlands.|Department of Pulmonary Diseases, Erasmus MC - University Medical Centre Rotterdam, Rotterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: de Mol
authors.affiliation: Department of Epidemiology, Erasmus MC - University Medical Centre Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.|Department of Pulmonary Diseases, Amphia Hospital Breda, Breda, The Netherlands.|Department of Pulmonary Diseases, Erasmus MC - University Medical Centre Rotterdam, Rotterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Visser
authors.affiliation: Department of Medical and Clinical Psychology, Centre of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Tilburg, The Netherlands.
authors.forename: B L
authors.initials: BL
authors.lastname: Den Oudsten
authors.affiliation: Department of Epidemiology, Erasmus MC - University Medical Centre Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. b.stricker@erasmusmc.nl.|Inspectorate of Health Care, The Hague, The Netherlands. b.stricker@erasmusmc.nl.
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
authors.affiliation: Department of Pulmonary Diseases, Amphia Hospital Breda, Breda, The Netherlands.|Department of Pulmonary Diseases, Erasmus MC - University Medical Centre Rotterdam, Rotterdam, The Netherlands.
authors.forename: J G J V
authors.initials: JG
authors.lastname: Aerts
mesh_terms: D000230:Adenocarcinoma / Q000523:psychology*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000523:psychology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017060:Patient Satisfaction; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014944:World Health Organization
keywords: Cancer Therapy Satisfaction Questionnaire; Chemotherapy; Expectations; Lung cancer; Satisfaction; Validity