title: Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis.
abstract: We describe the first case from India of ALECT2 amyloidosis. An adult Punjabi male presented with progressive renal dysfunction and non-nephrotic range proteinuria. Serum protein electrophoresis and immunofixation were normal, with mildly elevated serum free light chain ratio. A renal biopsy confirmed the presence of amyloid. Immunohistochemistry was negative for monoclonal light chains. Proteomic analysis confirmed the presence of ALECT2 amyloid. The present case highlights the need for confirmatory testing for typing of amyloid.
authors.affiliation: Department of Clinical Haematology. Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
authors.forename: Uday
authors.initials: U
authors.lastname: Kulkarni
authors.affiliation: Department of Nephrology. Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
authors.forename: Anna
authors.initials: A
authors.lastname: Valson
authors.affiliation: Department of General Pathology. Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
authors.forename: Anila
authors.initials: A
authors.lastname: Korula
authors.affiliation: Department of Clinical Haematology. Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Mathews