title: Normonanchocidins A, B and D, New Pentacyclic Guanidine Alkaloids from the Far-Eastern Marine Sponge Monanchora pulchra.
abstract: New pentacyclic guanidine alkaloids, normonanchocidins A, B and D (1-3) along with the earlier known monanchocidin A were isolated from the Far-Eastern marine sponge Monanchora pulchra. Structures of 1-3 were elucidated using ID- and 2D-NMR spectroscopic and mass spectrometric data. Compound 1 and a mixture of 2 and 3 (1:1) exhibited cytotoxic activities against human leukemia THP-1 cells with IC50 values of 2.1 μM and 3.7 μM, respectively, and against cervix epithelial carcinoma HeLa cells with IC50 of 3.8 μM and 6.8 μM, respectively.
authors.forename: Ksenya M
authors.initials: KM
authors.lastname: Tabakmakher
authors.forename: Tatyana N
authors.initials: TN
authors.lastname: Makarieva
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.forename: Alla G
authors.initials: AG
authors.lastname: Guzii
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Aleksandra S
authors.initials: AS
authors.lastname: Kuzmich
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D019791:Guanidine / Q000031:analogs & derivatives* / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D006146:Guanidines; C554301:monanchocidin; D019791:Guanidine