title: Molecularly based management of gliomas in clinical practice.
abstract: Histological subtyping and grading of malignancy are the cornerstone of the present World Health Organization (WHO) Classification of CNS tumors. However, among diffuse gliomas of the adult, patients with histologically identical tumors may have different outcomes. As the genomic analysis of these tumors has progressed, it has become clear that specific molecular features transcend histologically defined variants, and may become markers of prognostic and/or predictive value. At the present time, the number of molecular biomarkers with confirmed clinical relevance (MGMT promoter methylation, 1p/19q codeletion, IDH1/2 mutations) remains limited, but new technologies will hopefully provide new candidates requiring rigorous validation in well-designed clinical trials.
authors.affiliation: Department of Neuro-Oncology, University and City of Health and Science Hospital, Via Cherasco 15, 10126, Turin, Italy, rudarob@hotmail.com.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rudà
authors.forename: Alessia
authors.initials: A
authors.lastname: Pellerino
authors.forename: Michela
authors.initials: M
authors.lastname: Magistrello
authors.forename: Federica
authors.initials: F
authors.lastname: Franchino
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pinessi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Soffietti
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D005910:Glioma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006801:Humans; D060787:Neoplasm Grading
chemical_list: D014408:Biomarkers, Tumor