title: Systematic Nutritional Support in Allogeneic Hematopoietic Stem Cell Transplant Recipients.
abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) has become an established treatment modality for various hematological diseases. However, in allogeneic HSCT, patients often suffer from severe gastrointestinal complications caused by the conditioning regimen and acute/chronic graft-versus-host disease, which requires support by multidisciplinary nutritional support teams (NST). In addition, pretransplantation nutritional status can affect the clinical outcome after allogeneic HSCT. Therefore, it is important to refer the patient to a NST when becoming aware of nutritional problems before allogeneic HSCT. It is also important to follow nutritional status over the long term, as patients often suffer from various nutritional problems, such as malnutrition and metabolic syndrome, even late after allogeneic HSCT. In summary, NST can contribute to the improvement of nutritional status and possibly prognosis at every stage before and after allogeneic HSCT. Here, we aim to give a comprehensive overview of current understanding about nutritional support in allogeneic HSCT and try to provoke a constructive discussion to stimulate further investigation.
authors.affiliation: Department of Internal Medicine II, Division of Hematology, University Hospital of Würzburg, Würzburg, Germany; Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan. Electronic address: sfuji@ncc.go.jp.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Fuji
authors.affiliation: Department of Internal Medicine II, Division of Hematology, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.affiliation: Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, Tennessee.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Department of Internal Medicine II, Division of Hematology, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Kapp
mesh_terms: D064591:Allografts; D015992:Body Mass Index; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D002149:Energy Intake; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D005973:Glutamine / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000517:prevention & control; D008107:Liver Diseases / Q000453:epidemiology; D044342:Malnutrition / Q000209:etiology / Q000628:therapy*; D024821:Metabolic Syndrome / Q000453:epidemiology; D018529:Nutritional Support / Q000009:adverse effects / Q000379:methods*; D009765:Obesity / Q000453:epidemiology; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000379:methods; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D011379:Prognosis; D019172:Transplantation Conditioning / Q000009:adverse effects
chemical_list: D015525:Fatty Acids, Omega-3; D005973:Glutamine
keywords: Hematopoietic stem cell transplantation; Hyperglycemia; Long-term follow-up; Nutritional support