title: One-pot sonochemical synthesis of ferrocenyl derivatives via a three-component reaction in aqueous media.
abstract: An ultrasound-assisted three-component, one-pot domino reaction with ferrocenecarboxaldehyde is herein reported. The sequence of reactions entails the allylindation and dehydrative alkylation of stabilized C-nucleophiles (e.g. electron-rich-(hetero)aromatics and stabilized enols) and N-nucleophiles (e.g. azoles). Sonochemical reactions have been performed in three different high-intensity reactors: a bath (20.3 kHz, 60 W), as well as two cup horns working at 19.9 kHz (75 W) and 300.5 kHz (70 W) giving a library of 18 new ferrocenyl derivatives.
authors.affiliation: Dipartimento di Scienza e Alta Tecnologia, University of Insubria, Via Valleggio 11, 22100 Como, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Cappelletti
authors.affiliation: Dipartimento di Scienza e Alta Tecnologia, University of Insubria, Via Valleggio 11, 22100 Como, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Vaghi
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco and NIS - Centre for Nanostructured Interfaces and Surfaces, University of Turin, Via P. Giuria 9, I-10125 Turin, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Rinaldi
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco and NIS - Centre for Nanostructured Interfaces and Surfaces, University of Turin, Via P. Giuria 9, I-10125 Turin, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Rotolo
authors.affiliation: Dipartimento di Scienza e Alta Tecnologia, University of Insubria, Via Valleggio 11, 22100 Como, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Palmisano
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco and NIS - Centre for Nanostructured Interfaces and Surfaces, University of Turin, Via P. Giuria 9, I-10125 Turin, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Cravotto
authors.affiliation: Dipartimento di Scienza e Alta Tecnologia, University of Insubria, Via Valleggio 11, 22100 Como, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Penoni
keywords: Allylation; Domino reaction; Ferrocene; Indium; Multi-component reaction; Ultrasound