title: Post-thrombolysis hemorrhage in a patient with hypothyroidism and acute ischemic stroke: Case report.
abstract: Thrombolytic treatment with intravenous recombinant tissue plasminogen activator (rtPA) is an effective treatment for acute ischemic stroke. However, its effectiveness and risks in patients with hypothyroidism have not been reported. Here, we report the case of hemorrhagic transformation after intravenous rtPA thrombolysis treatment in a patient with acute ischemic stroke and hypothyroidism. An apparent edema formed around the hematoma and progressively worsened. He also developed lung infection, electrolyte imbalance, and abnormal liver and kidney functions, and eventually died within 1 month of symptom onset. Thus, our observations suggest that caution should be exercised for the administration of intravenous rtPA thrombolysis to patients with hypothyroidism.
authors.affiliation: Neurology Department, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Furong
authors.initials: F
authors.lastname: Gu
authors.affiliation: Neurology Department, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.affiliation: Neurology Department, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Rongjie
authors.initials: R
authors.lastname: Chen
authors.affiliation: Neurology Department, Tianjin Huanhu Hospital, Tianjin, China. Electronic address: hhyyxxl@163.com.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Xu
mesh_terms: D002545:Brain Ischemia / Q000188:drug therapy*; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D017809:Fatal Outcome; D006801:Humans; D007037:Hypothyroidism; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects*
chemical_list: D010959:Tissue Plasminogen Activator
keywords: Acute ischemic stroke; Edema; Hypothyroidism; Recombinant tissue plasminogen activator; Thrombolysis