title: Effect of salicylic acid on early life stages of common carp (Cyprinus carpio).
abstract: Environmental concentrations of pharmaceutical residues are often low; nevertheless, they are designed to have biological effects at low doses. The aim of this study was to assess the effects of salicylic acid on the growth and development of common carp (Cyprinus carpio) early life stages with respect to antioxidant defence enzymes. An embryo-larval toxicity test lasting 34 days was performed according to OECD guidelines 210 (Fish, Early-life Stage Toxicity Test). The tested concentrations were 0.004, 0.04, 0.4, 4 and 20mg/l of salicylic acid. Hatching, early ontogeny, and both morphometric and condition characteristics were significantly influenced by subchronic exposure to salicylic acid. Also, changes in antioxidant enzyme activity and an increase in lipid peroxidation were observed. The LOEC value was found to be 0.004 mg/l salicylic acid. The results of our study confirm the suggestion that subchronic exposure to salicylic acid at environmental concentrations can have significant effects on aquatic vertebrates.
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Dana
authors.initials: D
authors.lastname: Zivna
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic. Electronic address: H14023@vfu.cz.
authors.forename: Pavla
authors.initials: P
authors.lastname: Sehonova
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Plhalova
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Marsalek
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Blahova
authors.affiliation: Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Prokes
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Divisova
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Vlasta
authors.initials: V
authors.lastname: Stancova
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Radka
authors.initials: R
authors.lastname: Dobsikova
authors.affiliation: Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Frantisek
authors.initials: F
authors.lastname: Tichy
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Siroka
authors.affiliation: Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Svobodova
mesh_terms: D000818:Animals; D002347:Carps / Q000196:embryology* / Q000254:growth & development*; D004305:Dose-Response Relationship, Drug; D008018:Life Cycle Stages / Q000187:drug effects*; D020156:Salicylic Acid / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D014874:Water Pollutants, Chemical; D020156:Salicylic Acid
keywords: Lipid peroxidation; NSAIDs; Oxidative stress; Pharmaceutical residues