title: Midline Brain Abnormalities Across Psychotic and Mood Disorders.
abstract: Patients with schizophrenia are known to have increased prevalence of abnormalities in midline brain structures, such as a failure of the septum pellucidum to fuse (cavum septum pellucidum) and the absence of the adhesio interthalamica. This is the first study to investigate the prevalence of these abnormalities across a large multidiagnostic sample. Presence of cavum septum pellucidum and absence of the adhesio interthalamica was assessed in 639 patients with chronic schizophrenia, delusional disorder, schizoaffective disorder, bipolar disorder, major depressive disorder, or a first episode of psychosis, mania or unipolar depression. This was compared with 223 healthy controls using logistic-regression-derived odds ratios (OR). Patients with psychotic or mood disorders showed an increased prevalence of both abnormalities (OR of cavum septum pellucidum = 2.1, OR of absence of the adhesio interthalamica = 2.6, OR of both cavum septum pellucidum and absence of the adhesio interthalamica = 3.8, all P < .001). This increased prevalence was separately observed in nearly all disorders as well as after controlling for potential confounding factors. This study supports a general increased prevalence of midline brain abnormalities across mood and psychotic disorders. This nonspecificity may suggest that these disorders share a common neurodevelopmental etiology.
authors.forename: Ramón
authors.initials: R
authors.lastname: Landin-Romero
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain; benedikt.amann@gmail.com.
authors.forename: Benedikt L
authors.initials: BL
authors.lastname: Amann
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain;
authors.forename: Salvador
authors.initials: S
authors.lastname: Sarró
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain;
authors.forename: Amalia
authors.initials: A
authors.lastname: Guerrero-Pedraza
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain;
authors.forename: Victor
authors.initials: V
authors.lastname: Vicens
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain;
authors.forename: Elena
authors.initials: E
authors.lastname: Rodriguez-Cano
authors.affiliation: CIBERSAM, Madrid, Spain; Hospital Clinic, Universitat de Barcelona, IDIBAPS, Barcelona, Spain;
authors.forename: Eduard
authors.initials: E
authors.lastname: Vieta
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain;
authors.forename: Raymond
authors.initials: R
authors.lastname: Salvador
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain;
authors.forename: Edith
authors.initials: E
authors.lastname: Pomarol-Clotet
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain; Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College, London, UK.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Radua
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology / Q000473:pathology*; D001921:Brain / Q000002:abnormalities*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009421:Nervous System Malformations / Q000453:epidemiology / Q000473:pathology*; D015995:Prevalence; D011618:Psychotic Disorders / Q000453:epidemiology / Q000473:pathology*; D012559:Schizophrenia / Q000453:epidemiology / Q000473:pathology*; D012563:Schizophrenia, Paranoid / Q000453:epidemiology / Q000473:pathology; D012688:Septum Pellucidum / Q000002:abnormalities*; D013788:Thalamus / Q000002:abnormalities*; D055815:Young Adult
keywords: absent adhesio interthalamica; cavum septum pellucidum; midline brain; mood disorders; psychotic disorders; structural abnormalities