title: Childhood acute lymphoblastic leukemia: Integrating genomics into therapy.
abstract: Acute lymphoblastic leukemia (ALL), the most common malignancy of childhood, is a genetically complex entity that remains a major cause of childhood cancer-related mortality. Major advances in genomic and epigenomic profiling during the past decade have appreciably enhanced knowledge of the biology of de novo and relapsed ALL and have facilitated more precise risk stratification of patients. These achievements have also provided critical insights regarding potentially targetable lesions for the development of new therapeutic approaches in the era of precision medicine. In this review, the authors delineate the current genetic landscape of childhood ALL, emphasizing patient outcomes with contemporary treatment regimens as well as therapeutic implications of newly identified genomic alterations in specific subsets of ALL.
authors.affiliation: Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.|Department of Pediatrics, University of Pennsylvania Perelman School of Medicine and Abramson Cancer Center, Philadelphia, Pennsylvania.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Tasian
authors.affiliation: University of California, San Francisco Benioff Children's Hospital, San Francisco, California.|Helen Diller Family Comprehensive Cancer Center, San Francisco, California.
authors.forename: Mignon L
authors.initials: ML
authors.lastname: Loh
authors.affiliation: Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Hunger
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods; D006801:Humans; D007223:Infant; D058990:Molecular Targeted Therapy; D009154:Mutation; D057285:Precision Medicine; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000628:therapy*
keywords: acute lymphoblastic leukemia; cytogenetics; genomics; pediatrics; therapy