title: Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes.
abstract: Endometriosis is a prevalent benign disease, despite sharing several similarities with malignancies, such as the possibility of lymphatic spread. In malignancies, chemokines play a sovereign role in the process of metastasis. Metastasis-related chemokine axes have not yet been assessed in deep-infiltrating endometriosis (DIE), and this investigation was the aim of our study. The expression of these chemokines was investigated by immunohistochemistry in rectovaginal DIE lesions and in matched pelvic sentinel lymph nodes (PSLNs) of patients with endometriosis (n = 27), and their expression in the eutopic endometrium (EE) of endometriosis-free women (n = 20) was used as controls. Their staining pattern in rectovaginal DIE, in endometriotic lesions affecting the PSLN as well as in the EE of patients without endometriosis was characterized for the first time. Overall, these chemokines were highly expressed in DIE and endometriosis in PSLN. Chemokines might be involved in the spread of endometriosis and should be further investigated.
authors.affiliation: Clinic for Gynecology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil giuborrelli@me.com sylvia.mechsner@charite.de.
authors.forename: G M
authors.initials: GM
authors.lastname: Borrelli
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: M S
authors.initials: MS
authors.lastname: Abrão
authors.affiliation: Institute of Pathology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
authors.forename: E T
authors.initials: ET
authors.lastname: Taube
authors.affiliation: Institute of Pathology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Darb-Esfahani
authors.affiliation: Clinic for Gynecology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany Department of Gynecology, Asklepios Klinik Harburg, Hamburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Köhler
authors.affiliation: Clinic for Gynecology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Kaufmann
authors.affiliation: Clinic for Gynecology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Chiantera
authors.affiliation: Clinic for Gynecology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany giuborrelli@me.com sylvia.mechsner@charite.de.
authors.forename: S
authors.initials: S
authors.lastname: Mechsner
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002465:Cell Movement; D018925:Chemokines / Q000032:analysis*; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018925:Chemokines
keywords: chemokines; endometriosis; lymphatic spread; pelvic sentinel lymph node