title: Validation of Accelerometer Prediction Equations in Children with Chronic Disease.
abstract: The purpose of this study was to assess the criterion validity of existing accelerometer-based energy expenditure (EE) prediction equations among children with chronic conditions, and to develop new prediction equations. Children with congenital heart disease (CHD), cystic fibrosis (CF), dermatomyositis (JDM), juvenile arthritis (JA), inherited muscle disease (IMD), and hemophilia (HE) completed 7 tasks while EE was measured using indirect calorimetry with counts determined by accelerometer. Agreement between predicted EE and measured EE was assessed. Disease-specific equations and cut points were developed and cross-validated. In total, 196 subjects participated. One participant dropped out before testing due to time constraints, while 15 CHD, 32 CF, 31 JDM, 31 JA, 30 IMD, 28 HE, and 29 healthy controls completed the study. Agreement between predicted and measured EE varied across disease group and ranged from (ICC) .13-.46. Disease-specific prediction equations exhibited a range of results (ICC .62-.88) (SE 0.45-0.78). In conclusion, poor agreement was demonstrated using current prediction equations in children with chronic conditions. Disease-specific equations and cut points were developed.
authors.affiliation: Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Samantha
authors.initials: S
authors.lastname: Stephens
authors.forename: Tim
authors.initials: T
authors.lastname: Takken
authors.forename: Dale W
authors.initials: DW
authors.lastname: Esliger
authors.forename: Eleanor
authors.initials: E
authors.lastname: Pullenayegum
authors.forename: Joseph
authors.initials: J
authors.lastname: Beyene
authors.forename: Mark
authors.initials: M
authors.lastname: Tremblay
authors.forename: Jane
authors.initials: J
authors.lastname: Schneiderman
authors.forename: Doug
authors.initials: D
authors.lastname: Biggar
authors.forename: Pat
authors.initials: P
authors.lastname: Longmuir
authors.forename: Brian
authors.initials: B
authors.lastname: McCrindle
authors.forename: Audrey
authors.initials: A
authors.lastname: Abad
authors.forename: Dan
authors.initials: D
authors.lastname: Ignas
authors.forename: Janjaap
authors.initials: J
authors.lastname: Van Der Net
authors.forename: Brian
authors.initials: B
authors.lastname: Feldman
mesh_terms: D061725:Accelerometry / Q000592:standards*; D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D004734:Energy Metabolism / Q000502:physiology; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D011379:Prognosis; D011788:Quality of Life; D015203:Reproducibility of Results; D018570:Risk Assessment