title: The Adjunctive Effect of Platelet-Rich Fibrin to Connective Tissue Graft in the Treatment of Buccal Recession Defects: Results of a Randomized, Parallel-Group Controlled Trial.
abstract: BACKGROUND
  Platelet-rich fibrin (PRF) is an autologous preparation that has encouraging effects in healing and regeneration. The aim of this trial is to evaluate the effectiveness of coronally advanced flap (CAF) + connective tissue graft (CTG) + PRF in Miller Class I and II recession treatment compared to CAF + CTG.
  
  
  METHODS
  Forty patients were treated surgically with either CAF + CTG + PRF (test group) or CAF + CTG (control group). Clinical parameters of plaque index, gingival index, vertical recession (VR), probing depth, clinical attachment level (CAL), keratinized tissue width (KTW), horizontal recession (HR), mucogingival junction localization, and tissue thickness (TT) were recorded at baseline and 3 and 6 months after surgery. Root coverage (RC), complete RC (CRC), attachment gain (AG), and keratinized tissue change (KTC) were also calculated.
  
  
  RESULTS
  All individuals completed the entire study period. At baseline, mean VR, HR, CAL, KTW, and TT values were similar (P >0.05). In both groups, all parameters showed significant improvement after treatment (P <0.001), and except TT (P <0.05), no intergroup difference was observed at 6 months after surgery. The amount of RC and AG, but not KTC and CRC, was higher in the PRF-applied group (P <0.05).
  
  
  CONCLUSIONS
  According to the results, the addition of PRF did not further develop the outcomes of CAF + CTG treatment except increasing the TT. However, this single trial is not sufficient to advocate the true clinical effect of PRF on recession treatment with CAF + CTG, and additional trials are needed.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
authors.forename: Huseyin Gencay
authors.initials: HG
authors.lastname: Keceli
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Kirikkale University, Kirikkale, Turkey.
authors.forename: Gulen
authors.initials: G
authors.lastname: Kamak
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Kirikkale University, Kirikkale, Turkey.
authors.forename: Ebru Olgun
authors.initials: EO
authors.lastname: Erdemir
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Kirikkale University, Kirikkale, Turkey.
authors.forename: Mustafa Serdar
authors.initials: MS
authors.lastname: Evginer
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Hacettepe University.
authors.forename: Anil
authors.initials: A
authors.lastname: Dolgun
mesh_terms: D003238:Connective Tissue / Q000637:transplantation*; D005881:Gingiva; D005889:Gingival Recession / Q000628:therapy*; D006801:Humans; D000073183:Platelet-Rich Fibrin; D014092:Tooth Root; D016896:Treatment Outcome
keywords: Connective tissue; gingiva; gingival recession; platelet-rich plasma; surgical flaps; tissue transplantation