title: Cardiac Magnetic Resonance Scar Imaging for Sudden Cardiac Death Risk Stratification in Patients with Non-Ischemic Cardiomyopathy.
abstract: In patients with non-ischemic cardiomyopathy (NICM), risk stratification for sudden cardiac death (SCD) and selection of patients who would benefit from prophylactic implantable cardioverter-defibrillators remains challenging. We aim to discuss the evidence of cardiac magnetic resonance (CMR)-derived myocardial scar for the prediction of adverse cardiovascular outcomes in NICM. From the 15 studies analyzed, with a total of 2747 patients, the average prevalence of myocardial scar was 41%. In patients with myocardial scar, the risk for adverse cardiac events was more than 3-fold higher, and risk for arrhythmic events 5-fold higher, as compared to patients without scar. Based on the available observational, single center studies, CMR scar assessment may be a promising new tool for SCD risk stratification, which merits further investigation.
authors.affiliation: Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
authors.forename: Eun Kyoung
authors.initials: EK
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand. ; Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Pairoj
authors.initials: P
authors.lastname: Chattranukulchai
authors.affiliation: Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC 27710, USA. ; Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Igor
authors.initials: I
authors.lastname: Klem
mesh_terms: D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D009202:Cardiomyopathies / Q000175:diagnosis*; D002921:Cicatrix / Q000175:diagnosis*; D016757:Death, Sudden, Cardiac; D017147:Defibrillators, Implantable; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D009206:Myocardium / Q000473:pathology; D018570:Risk Assessment; D012307:Risk Factors
keywords: Cardiac magnetic resonance; Non-ischemic cardiomyopathy; Sudden cardiac death