title: European Society of Gynecological Oncology Task Force for Fertility Preservation: Clinical Recommendations for Fertility-Sparing Management in Young Endometrial Cancer Patients.
abstract: Endometrial cancer (EC) in young women of reproductive age is a relatively rare diagnosis. However, since in the modern era women delay their childbearing for a variety of social reasons, more and more women in the near future will be nulliparous and have a diagnosis of EC at the same time. Hence, a more conservative approach of EC is desirable to preserve fertility of these women, without compromising their survival. Recently, the number of studies reporting encouraging results on fertility-sparing management of EC with high dose of progestins is increasing. It seems that preserving the uterus and the ovaries in a carefully selected patient with EC confers only a very small risk combined with an enormous benefit. Selection of women suitable for such a conservative approach, as well as method of treatment, follow-up, recurrence, obstetric outcomes, and survival rates are very important parameters when consulting women with EC wishing to preserve their fertility. In this article, we try to elucidate all the previously mentioned aspects and formulate clinical recommendations, based on published data, about the most proper approach and consultation of these patients.
authors.affiliation: *First Department of Obstetrics and Gynecology, Athens University, Alexandra Hospital, Athens, Greece; †Gynaecological Oncology Unit, Barts Health NHS Trust, London, United Kingdom; ‡Gustave Roussy, Villejuif; §Institut National de la Santé et de la Recherche Médicale, Lyon; ∥University of Paris, Paris, France; ¶Beatson Oncology Centre, Gartnavel General Hospital, Glasgow, United Kingdom; #Department of Gynecology, Charité Campus Mitte, Berlin, Germany; **Department of Obstetrics and Gynecology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; and ††Gynäkologie und Geburtshilfe, Hochtaunus-Kliniken Bad Homburg, Bad Homburg, Germany.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Rodolakis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Biliatis
authors.forename: Philippe
authors.initials: P
authors.lastname: Morice
authors.forename: Nick
authors.initials: N
authors.lastname: Reed
authors.forename: Mandy
authors.initials: M
authors.lastname: Mangler
authors.forename: Vesna
authors.initials: V
authors.lastname: Kesic
authors.forename: Dominik
authors.initials: D
authors.lastname: Denschlag
mesh_terms: D026683:Advisory Committees; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005060:Europe; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology*; D017410:Practice Guidelines as Topic / Q000592:standards*; D011247:Pregnancy; D011372:Progestins / Q000008:administration & dosage*; D011379:Prognosis; D012307:Risk Factors; D012955:Societies, Medical; D055815:Young Adult
chemical_list: D011372:Progestins