title: High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma.
abstract: Valosin-containing protein (VCP) is one of the AAA-ATPase superfamily members. The correlation between elevated expression of VCP and progression, prognosis, and the metastatic potential has been identified in various tumor types. However, the clinical impact of VCP in breast carcinoma has not been investigated. In the current study, the expression of VCP in 421 breast tumors and adjacent normal breast tissues was examined to investigate the correlation between VCP expression and clinicopathological features in patients with breast carcinoma. We found that the expression of VCP correlated with the TNM stage, Ki67 labeling, and lymph node metastasis (LNM). The expression of VCP was increased significantly in the cytoplasm of cancer cells compared to normal mammary epithelial cells, which was associated with decreased overall survival rates of patients with breast carcinoma (P < 0.001). In conclusion, this study demonstrates significant correlation between the cytoplasmic expression of VCP and adverse prognosis in breast carcinoma, suggesting that VCP may serve as a prognostic biomarker in breast carcinoma.
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, Haping Road No.150, Nangang District, Harbin, 150081, Heilongjiang Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, Haping Road No.150, Nangang District, Harbin, 150081, Heilongjiang Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Niu
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, Haping Road No.150, Nangang District, Harbin, 150081, Heilongjiang Province, China.
authors.forename: Xianyu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, Haping Road No.150, Nangang District, Harbin, 150081, Heilongjiang Province, China.
authors.forename: Zhenbin
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, Haping Road No.150, Nangang District, Harbin, 150081, Heilongjiang Province, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, Haping Road No.150, Nangang District, Harbin, 150081, Heilongjiang Province, China. pangda@ems.hrbmu.edu.cn.
authors.forename: Da
authors.initials: D
authors.lastname: Pang
mesh_terms: D000251:Adenosine Triphosphatases / Q000096:biosynthesis* / Q000235:genetics; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018797:Cell Cycle Proteins / Q000096:biosynthesis* / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D046888:Tissue Array Analysis; D000074405:Valosin Containing Protein
chemical_list: D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D000251:Adenosine Triphosphatases; C000614178:VCP protein, human; D000074405:Valosin Containing Protein
keywords: Breast cancer; Immunohistochemistry; Prognosis; VCP