title: E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation.
abstract: It is estimated that 10-20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, the role of onco-viruses in cancer progression to a metastatic form is of particular interest. Recent studies reported that E5 and E6/E7 onco-proteins of high-risk HPVs could enhance cancer progression via the initiation of the epithelial-mesenchymal transition (EMT) event. Herein, we discuss the association between E5 as well as E6/E7 of high-risk HPV and cancer progression.
authors.affiliation: a College of Medicine & Biomedical Research Center ; Qatar University ; Doha , Qatar.|b Oncology Department ; McGill University ; Montreal , Canada.|c Department of Mechanical Engineering ; Concordia University ; Montreal , Canada.|d Syrian Research Cancer Center of the Syrian Society against Cancer ; Aleppo , Syria.
authors.forename: Ala-Eddin
authors.initials: AE
authors.lastname: Al Moustafa
mesh_terms: D000818:Animals; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000821:virology*; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D027383:Papillomaviridae / Q000502:physiology*; D030361:Papillomavirus Infections / Q000473:pathology* / Q000821:virology*
chemical_list: D009856:Oncogene Proteins, Viral
keywords: E5; E6/E7; cancer progression; gene cooperation; high-risk HPV