title: Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.
abstract: The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum. In addition, IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were substantially following oral mushroom polysaccharides treatments. The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides.
authors.affiliation: College of Life Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Da' an District, Taipei City 10617, Taiwan.
authors.forename: Wan-Jhen
authors.initials: WJ
authors.lastname: Wang
authors.affiliation: College of Life Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Da' an District, Taipei City 10617, Taiwan.
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Wu
authors.affiliation: Department of Research and Development, Super Beta Glucan Inc., Irvine, CA, USA.
authors.forename: Sherwin
authors.initials: S
authors.lastname: Chen
authors.affiliation: Graduate Institute of Integration of Traditional Chinese Medicine with Western Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
authors.forename: Chi-Feng
authors.initials: CF
authors.lastname: Liu
authors.affiliation: College of Life Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Da' an District, Taipei City 10617, Taiwan.
authors.forename: Shiu-Nan
authors.initials: SN
authors.lastname: Chen
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000378:metabolism*; D016207:Cytokines / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D059016:Tumor Microenvironment / Q000187:drug effects; D047071:beta-Glucans / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D012333:RNA, Messenger; D047071:beta-Glucans