title: The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice.
abstract: Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding of the life cycle of nanoparticles in the body. Here, we investigate the long-term fate of gold/iron oxide heterostructures after intravenous injection in mice. We show these heterostructures degrade in vivo and that the magnetic and optical properties change during the degradation process. These particles eventually eliminate from the body. The comparison of two different coating shells for heterostructures, amphiphilic polymer or polyethylene glycol, reveals the long lasting impact of initial surface properties on the nanocrystal degradability and on the kinetics of elimination of magnetic iron and gold from liver and spleen. Modulation of nanoparticles reactivity to the biological environment by the choice of materials and surface functionalization may provide new directions in the design of multifunctional nanomedicines with predictable fate.
authors.affiliation: Laboratoire Matières et Systèmes Complexes, UMR 7057 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.|Inserm U970, Paris Cardiovascular Research Center-PARCC/Université Paris-Descartes , 56 rue Leblanc, Paris 75015, France.
authors.forename: Jelena
authors.initials: J
authors.lastname: Kolosnjaj-Tabi
authors.affiliation: Laboratoire Matériaux et Phénomènes Quantiques, UMR 7162 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.
authors.forename: Yasir
authors.initials: Y
authors.lastname: Javed
authors.affiliation: Laboratoire Matières et Systèmes Complexes, UMR 7057 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.|Laboratoire Matériaux et Phénomènes Quantiques, UMR 7162 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.
authors.forename: Lénaic
authors.initials: L
authors.lastname: Lartigue
authors.affiliation: Laboratoire Matières et Systèmes Complexes, UMR 7057 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Volatron
authors.affiliation: Laboratoire Matières et Systèmes Complexes, UMR 7057 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.
authors.forename: Dan
authors.initials: D
authors.lastname: Elgrabli
authors.affiliation: Laboratoire Matières et Systèmes Complexes, UMR 7057 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.
authors.forename: Iris
authors.initials: I
authors.lastname: Marangon
authors.affiliation: Istituto Italiano di Tecnologia , via Morego 30, Genova 16163, Italy.
authors.forename: Giammarino
authors.initials: G
authors.lastname: Pugliese
authors.affiliation: ISTeP, UMR 7193 CNRS/Université Pierre et Marie Curie , 4 place Jussieu, Paris 75005, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Caron
authors.affiliation: Istituto Italiano di Tecnologia , via Morego 30, Genova 16163, Italy.
authors.forename: Albert
authors.initials: A
authors.lastname: Figuerola
authors.affiliation: Laboratoire Matières et Systèmes Complexes, UMR 7057 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Luciani
authors.affiliation: Istituto Italiano di Tecnologia , via Morego 30, Genova 16163, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Pellegrino
authors.affiliation: Laboratoire Matériaux et Phénomènes Quantiques, UMR 7162 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Alloyeau
authors.affiliation: Laboratoire Matières et Systèmes Complexes, UMR 7057 CNRS/Université Paris Diderot , 10 rue Alice Domon et Léonie Duquet, Paris F-75205 Cedex 13, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Gazeau
mesh_terms: D000375:Aging / Q000502:physiology*; D000475:Alkenes / Q000737:chemistry; D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics*; D005290:Ferric Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D006046:Gold / Q000737:chemistry / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D058185:Magnetite Nanoparticles / Q000032:analysis* / Q000737:chemistry / Q000648:ultrastructure; D008299:Maleic Anhydrides / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D050997:Nanomedicine / Q000295:instrumentation / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013154:Spleen / Q000378:metabolism / Q000648:ultrastructure; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D000475:Alkenes; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D008299:Maleic Anhydrides; D011108:Polymers; C000499:ferric oxide; C016683:polymaleic anhydride; D011092:Polyethylene Glycols; D006046:Gold; C109760:1-octadecene
keywords: aging; biodistribution; degradation; elimination; gold nanoparticles; heterostructure; iron oxide nanoparticles; nanotoxicity