title: Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review.
abstract: Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)/T-cell lymphoma (IVNKL) have been reported. Our case is A 47-year-old female presented with erythematous patches and plaques on the lower extremities mimicking panniculitis clinically. A skin biopsy revealed intravascular lymphoma (IVL) with a NK/T cell phenotype (positive for CD3, and granzyme B and negative for CD20, CD4, CD8, CD5). The lymphoma cells were also positive for Epstein-Barr virus by Epstein-Barr virus-encoded RNA in situ hybridization test. Because this type of lymphoma is extremely rare, our case is documented and compared with the previously reported cases.
authors.affiliation: Department of Pathology, College of medicine, and king Khalid university hospital, King saud university, P.O. BOX 2925, Riyadh, 11461, Saudi Arabia. ahmedbgj@hotmail.com.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Alhumidi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D054391:Lymphoma, Extranodal NK-T-Cell / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D016410:Lymphoma, T-Cell, Cutaneous / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D008875:Middle Aged; D015434:Panniculitis / Q000473:pathology*; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000235:genetics; D012878:Skin Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology* / Q000821:virology
chemical_list: D014408:Biomarkers, Tumor; D012367:RNA, Viral