title: Proteomic methods for biomarker discovery and validation. Are we there yet?
abstract: Noninvasive molecular biomarkers are becoming attractive tools to monitor disease progression, aid drug development programs and use as surrogate outcome measures in clinical trials. Cutting edge proteomic methods to assay biomarkers in body fluids have been developed in the past few years, but transitioning them to clinical practice has been slow and depends on the qualification of both the method and the biomarker.
authors.affiliation: Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA.
authors.forename: Yetrib
authors.initials: Y
authors.lastname: Hathout
mesh_terms: D015415:Biomarkers; D002853:Chromatography, Liquid; D040901:Proteomics; D053719:Tandem Mass Spectrometry
chemical_list: D015415:Biomarkers
keywords: SomaScan; antibody bead arrays; biomarkers; biomarkers validation; proteomics; targeted mass spectrometry