title: Ovarian serous carcinogenesis from tubal secretory cells.
abstract: Due to a poor understanding of tumorigenesis, ovarian cancers remain the most lethal gynecologic malignancy and cause horrific deaths. In the last decade, a new dualistic model for ovarian cancer was proposed, wherein ovarian serous cancers are classified as either high-grade or low-grade, with each having different tumorigenic processes, and pathologic and clinical features. Surprisingly, both high- and low-grade ovarian serous cancers were recently found to originate not in the ovaries, but rather from the secretory cells of the fallopian tube, mostly from the tubal fimbriated ends. In this article, we review the evidentiary basis for the aforementioned paradigm shift in the cell origin of ovarian serous cancers, as well as its potential clinical implications.
authors.affiliation: Department of Pathology, Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA and Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA and Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, China.
authors.forename: Linxuan
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA, and Department of Pathology, Shanxi Medical University, China.
authors.forename: Lingmin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pathology, and Department of Obstetrics and Gynecology, University of Arizona College of Medicine, Tucson, AZ, USA.
authors.forename: Binlie
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, China.
authors.forename: Beihua
authors.initials: B
authors.lastname: Kong
authors.affiliation: Department of Molecular and Cellular Biology, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. guangyao@email.arizona.edu.
authors.forename: Guang
authors.initials: G
authors.lastname: Yao
authors.affiliation: Department of Pathology, Department of Obstetrics and Gynecology, Arizona Cancer Center, University of Arizona, Tucson, AZ, and Department of Pathology, UT Southestern Medical Center, Dallas, TX USA. wenxin.zheng@UTSouthwestern.edu.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D000077216:Carcinoma, Ovarian Epithelial; D002454:Cell Differentiation; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005187:Fallopian Tubes / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D051379:Mice; D060787:Neoplasm Grading; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor