title: Paired measurement of serum amyloid A (SAA) and paraoxonase 1 (PON1) as useful markers in breast cancer recurrence.
abstract: OBJECTIVE
  Paraoxonase 1 (PON1) and serum amyloid A (SAA) are carried by HDL. In case of inflammation, SAA and PON1 tend to change in opposite direction. In this study we determined if inflammation leads to altered PON1 activity using three different substrate hydrolysis rates, paraoxonase (PON), arylesterase (ARE) and lactonase (LAC) in breast cancer recurrence.
  
  
  METHODS
  49 patients with a recurrence of breast cancer were analyzed for SAA, CRP, lipids, oxidized LDL, PON, ARE and LAC. Distribution of PON1 activities across the quartiles of CRP and SAA were compared by the Kruskal Wallis test. Non-parametric estimates of the survivor function were computed with Kaplan-Meier method. The association of SAA and ARE with short term death was assessed by logistic regression models.
  
  
  RESULTS
  HDL and ARE decrease significantly across the quartiles of CRP. No significant differences were observed across SAA quartiles. The survival time was significantly related to the level of SAA (log rank: p<0.001) as well as the level of ARE (log rank: p=0.039). SAA and ARE were independently related to survival time below one year.
  
  
  CONCLUSIONS
  PON1 does not seem to be directly affected by SAA, for any of the tested substrates, PON, ARE and LAC. The combined measurement of SAA and ARE could be a useful tool in this clinical situation, since they are independently related to short term death.
authors.affiliation: Institut de Cancérologie de l'Ouest-Biopathologie, Boulevard Jacques Monod 44805 Saint-Herblain, France; Université de Nantes, MMS - EA 2160 - Mer Molécules Santé, IUML - Institut Universitaire Mer et Littoral - FR3473 CNRS, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Bobin-Dubigeon
authors.affiliation: Institut de Cancérologie de l'Ouest-Biopathologie, Boulevard Jacques Monod 44805 Saint-Herblain, France.
authors.forename: Armelle
authors.initials: A
authors.lastname: Lefrançois
authors.affiliation: Institut de Cancérologie de l'Ouest-Oncologie Chirurgicale, Boulevard Jacques Monod 44805 Saint-Herblain, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Classe
authors.affiliation: Institut de Cancérologie de l'Ouest-Biopathologie, Boulevard Jacques Monod 44805 Saint-Herblain, France.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Joalland
authors.affiliation: Institut de Cancérologie de l'Ouest-Biopathologie, Boulevard Jacques Monod 44805 Saint-Herblain, France; Université de Nantes, MMS - EA 2160 - Mer Molécules Santé, IUML - Institut Universitaire Mer et Littoral - FR3473 CNRS, France. Electronic address: jean-marie.bard@univ-nantes.fr.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Bard
mesh_terms: D043303:Aryldialkylphosphatase / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D000685:Serum Amyloid A Protein; C099252:oxidized low density lipoprotein; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Breast cancer; Inflammation; Paraoxonase; SAA