title: Gluten-free diet or alternative therapy: a survey on what parents of celiac children want.
abstract: OBJECTIVE
  Celiac disease (CD) is treated by life-long gluten-free diet (GFD). Novel therapies are under development. Willingness of CD children's parents to alternative therapies and GFD impact were evaluated.
  
  
  METHODS
  Parents of celiac children on GFD were investigated on need and preference for novel CD therapies, children's enrolment in trials, compliance to and personal judgment on GFD, health status (HS) and quality of life (QoL).
  
  
  RESULTS
  About 59.5% surveyed parents expressed the need for alternative therapies with a preference for vaccine-based strategy (39.9%). About 37.7% would accept enrollment in an ad hoc trial, 20.3% would agree to endoscopy during the trial. GFD compliance was 97.4% and well accepted by 93.8%. HS and QoL significantly improved during GFD (p < 0.001).
  
  
  CONCLUSIONS
  The introduction of novel therapies for CD is desirable for over half of parents, with preference for vaccines. Parents frown upon enrolment in new clinical trials and the subsequent need for additional endoscopy.
authors.affiliation: Center for the Prevention and Diagnosis of Celiac Disease, Gastroenterology and Digestive Endoscopy Unit, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, University of Milan , Milan , Italy and.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Norsa
authors.forename: Carolina
authors.initials: C
authors.lastname: Tomba
authors.forename: Carlo
authors.initials: C
authors.lastname: Agostoni
authors.forename: Federica
authors.initials: F
authors.lastname: Branchi
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Bardella
authors.forename: Leda
authors.initials: L
authors.lastname: Roncoroni
authors.forename: Dario
authors.initials: D
authors.lastname: Conte
authors.forename: Luca
authors.initials: L
authors.lastname: Elli
mesh_terms: D000293:Adolescent; D035843:Biomedical Research; D002446:Celiac Disease / Q000178:diet therapy / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D055050:Diet, Gluten-Free; D004724:Endoscopy; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006301:Health Services Needs and Demand; D006304:Health Status; D006801:Humans; D008297:Male; D010290:Parents; D010342:Patient Acceptance of Health Care; D010349:Patient Compliance; D011788:Quality of Life; D011795:Surveys and Questionnaires; D035703:Therapies, Investigational; D014612:Vaccines
chemical_list: D014612:Vaccines; D005983:Glutens
keywords: Celiac disease; gastroenterology; nutrition; pediatrics