title: EMSA Eritin Drives Expansion of Regulatory T Cells and Promotes T Cells Differentiation in Irradiated Mice.
abstract: Sublethal irradiation therapy in cancer treatment causes generalized immunosuppression, which results in a range of DNA damage. We examined the significance of a polyherbal medicine called "EMSA Eritin" on immunological responses in sublethally irradiated mice focusing on the involvement of Treg, naïve T cell, and also the development and differentiation of T cells in thymus. Normal BALB/c mice were sublethally irradiated with dose of 600 rad. The irradiated mice were then orally administered by EMSA Eritin once a day at different doses: 1.04, 3.12, 9.37 mg/g body weight. The treatment was performed for 14 days. On day 15, immunological responses were observed by analyzing the status of Treg and differentiation of T cells in thymus. The administration of EMSA Eritin to irradiated mice resulted in a significant increase of pre T cells, Treg cells, and naïve T cells, which in general could maintain and normalize healthy condition in mice.
authors.affiliation: University of Brawijaya, Malang, Indonesia mansur.ibr123@gmail.com.
authors.forename: Mansur
authors.initials: M
authors.lastname: Ibrahim
authors.affiliation: University of Brawijaya, Malang, Indonesia.
authors.forename: Edi
authors.initials: E
authors.lastname: Widjajanto
authors.affiliation: University of Brawijaya, Malang, Indonesia.
authors.forename: M Aris
authors.initials: MA
authors.lastname: Widodo
authors.affiliation: University of Brawijaya, Malang, Indonesia.
authors.forename: Sutiman B
authors.initials: SB
authors.lastname: Sumitro
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects* / Q000528:radiation effects*; D002478:Cells, Cultured; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D014916:Whole-Body Irradiation
chemical_list: D010936:Plant Extracts
keywords: Treg cells; differentiation; irradiation; naïve T cells; sublethal