title: Effect of Size-Dependent Photodestructive Efficacy by Gold Nanomaterials with Multiphoton Laser.
abstract: The photostability, photodestructive efficacy, two-photon excitation cross section, and two-photon fluorescence of gold nanoparticles conjugated with a hydrophilic photosensitizer, indocyanine green, via multiphoton laser exhibited an increased size effect in methicillin-resistant Staphylococcus aureus and A549 cancer cells that was dependent on the size of multifunctional gold nanomaterials, but the effect only occurred when nanomaterials within 100 nm in diameter were used. Besides, the enhanced effectiveness of photodestruction, photostability, and contrast probe indicated an additive effect in the therapeutic and imaging efficiency of multifunctional gold nanomaterials. Consequently, the preparation of the multifunctional gold nanomaterials and their use in biomedical applications via multiphoton laser is an alternative and potential therapeutic approach for killing bacteria and for ablating cancer cells.
authors.affiliation: †Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Wen-Tsan
authors.initials: WT
authors.lastname: Chang
authors.affiliation: ‡Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan 701, Taiwan.|§Department of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.|∥Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Shean-Jen
authors.initials: SJ
authors.lastname: Chen
authors.affiliation: ‡Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan 701, Taiwan.|§Department of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Chia-Yuan
authors.initials: CY
authors.lastname: Chang
authors.affiliation: §Department of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Yi-Hsien
authors.initials: YH
authors.lastname: Liu
authors.affiliation: ⊥Antagene, Inc., Santa Clara, California 95054, United States.
authors.forename: Chang-Hsin
authors.initials: CH
authors.lastname: Chen
authors.affiliation: #Institute of Polymer Science and Engineering, National Taiwan University, Taipei 106, Taiwan.
authors.forename: Chen-Han
authors.initials: CH
authors.lastname: Yang
authors.affiliation: ‡Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan 701, Taiwan.|▽Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Lawrence Chao-Shan
authors.initials: LC
authors.lastname: Chou
authors.affiliation: ▽Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan.|¶Instrument Center, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Jui-Cheng
authors.initials: JC
authors.lastname: Chang
authors.affiliation: §Department of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Li-Chung
authors.initials: LC
authors.lastname: Cheng
authors.affiliation: †Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan 701, Taiwan.|‡Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan 701, Taiwan.|∥Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Wen-Shuo
authors.initials: WS
authors.lastname: Kuo
authors.affiliation: †Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan 701, Taiwan.|◆Department of Pediatrics, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Jiu-Yao
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry / Q000633:toxicity; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000528:radiation effects; D036641:Microscopy, Fluorescence, Multiphoton; D010316:Particle Size; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000906:Antibodies; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D006046:Gold; D007208:Indocyanine Green
keywords: contrast probe; gold; methicillin-resistant Staphylococcus aureus; photodestructive; photostability; two-photon action cross section; two-photon fluorescence