title: Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity.
abstract: The metabolic interplay between hosts and viruses plays a crucial role in determining the outcome of viral infection. Viruses reorchestrate the host's primary metabolic gene networks, including genes associated with mevalonate and isoprenoid synthesis, to acquire the necessary energy and structural components for their viral life cycles. Recent work has demonstrated that the interferon-mediated antiviral response suppresses the sterol pathway through production of a signalling molecule, 25-hydroxycholesterol (25HC). This oxysterol has been shown to exert multiple effects, both through incorporation into host cellular membranes as well as through transcriptional control. Herein, we summarize our current understanding of the multifunctional roles of 25HC in the mammalian innate antiviral response.
authors.affiliation: a Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.|b Life Sciences Division, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.
authors.forename: Ragunath
authors.initials: R
authors.lastname: Singaravelu
authors.affiliation: a Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.|b Life Sciences Division, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Srinivasan
authors.affiliation: a Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.|b Life Sciences Division, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.|c Department of Chemistry, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
authors.forename: John Paul
authors.initials: JP
authors.lastname: Pezacki
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D006706:Homeostasis; D006801:Humans; D006888:Hydroxycholesterols / Q000494:pharmacology*; D007113:Immunity, Innate / Q000187:drug effects*; D013250:Steroid Hydroxylases / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D006888:Hydroxycholesterols; C007997:25-hydroxycholesterol; D013250:Steroid Hydroxylases; C507384:cholesterol 25-hydroxylase
keywords: 25-hydroxycholesterol; 25-hydroxycholestérol; cholesterol-25-hydroxylase; cholestérol-25-hydroxylase; immunity; immunité; metabolism; métabolisme; virus