title: African American ethnicity is not associated with development of Barrett's oesophagus after erosive oesophagitis.
abstract: BACKGROUND
  Barrett's oesophagus is the primary risk factor for oesophageal adenocarcinoma; erosive oesophagitis is considered an intermediate step with Barrett's oesophagus development potential upon healing. Barrett's oesophagus occurs in 9-19% following erosive oesophagitis but minimal data exists in African Americans. The study aim was to determine if ethnicity is associated with Barrett's oesophagus formation following erosive oesophagitis.
  
  
  METHODS
  Retrospective review of endoscopies from September 2007 to December 2012 was performed. Inclusion criteria were erosive oesophagitis on index endoscopy, repeat endoscopy ≥6 weeks later and non-Hispanic white or African American ethnicity. Barrett's oesophagus frequency following erosive oesophagitis by ethnicity was compared.
  
  
  RESULTS
  A total of 14,303 patients underwent endoscopy during the study period; 1636 had erosive oesophagitis. Repeat endoscopy was performed on 125 non-Hispanic white or African American patients ≥6 weeks from the index procedure. Barrett's oesophagus occurred in 8% of non-Hispanic whites while no African American developed it on repeat endoscopy following erosive oesophagitis (p=0.029). No significant difference was seen between ethnic groups in any clinical parameter assessed.
  
  
  CONCLUSIONS
  African American ethnicity appears to result in decreased Barrett's oesophagus formation following erosive oesophagitis. Further investigation to demonstrate factors resulting in decreased Barrett's oesophagus formation among African Americans should be performed.
authors.affiliation: Department of Medicine, University of Florida/Jacksonville, Jacksonville, FL, United States.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Alkaddour
authors.affiliation: Division of Gastroenterology, University of Florida/Jacksonville, Jacksonville, FL, United States.
authors.forename: Camille
authors.initials: C
authors.lastname: McGaw
authors.affiliation: Division of Gastroenterology, University of Florida/Jacksonville, Jacksonville, FL, United States.
authors.forename: Rama
authors.initials: R
authors.lastname: Hritani
authors.affiliation: Department of Medicine, University of Florida/Jacksonville, Jacksonville, FL, United States.
authors.forename: Carlos
authors.initials: C
authors.lastname: Palacio
authors.affiliation: Department of Medicine, University of Florida/Jacksonville, Jacksonville, FL, United States.
authors.forename: Rahman
authors.initials: R
authors.lastname: Nakshabendi
authors.affiliation: Division of Gastroenterology, University of Florida/Jacksonville, Jacksonville, FL, United States.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Munoz
authors.affiliation: Division of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: kenneth-vega@ouhsc.edu.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Vega
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000208:ethnology*; D004724:Endoscopy; D004942:Esophagitis, Peptic / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology; D044465:White People
keywords: African Americans; Barrett's oesophagus; Erosive oesophagitis; Ethnicity; GERD