title: [Venous thromboembolism in patients with acute tuberculosis].
abstract: BACKGROUND
  Studies have demonstrated a link between tuberculosis and hypercoagulable state, with reported rates of 0,6%-10% venous thromboembolism (VTE) in all adults with tuberculosis. The present study aimed to evaluate the current incidence and characteristics of VTE in a large sample of patients with acute tuberculosis.
  
  
  METHODS
  We report a retrospective study about 26 patients who have confirmed tuberculosis complicated with VTE disease.
  
  
  RESULTS
  Sixteen men and ten women were brought together. The mean age was 42.58 years. The thromboembolic complication revealed tuberculosis among 5 patients, appearing during hospitalization of 21 patients among which 16 of them receiving antituberculosis drug. We have listed 10 cases of immediate pulmonary thromboembolism and 16 cases of deep vein thrombosis complicated with pulmonary embolism in 6 cases. Oral anticoagulation drug were associated with heparin after a mean of 4.57 days. Duration average of achievement of an effective dose was of 21.05 days and we prescribe low molecular weight heparin for 6 months on 2 cases. There was favorable evolution among 14 patients, 4 of them have lost sight and the evolution was fatal by cataclysmic haemoptysis in one case, a patient died hepatocellular insufficiency and 6 died by pulmonary embolism.
  
  
  CONCLUSIONS
  Immunological and hematological abnormalities are incriminated in the genesis of VTE disease during tuberculosis by creating hypercoagulate state. The accumulation of morbidity of these two affections as well as the difficulty of therapeutic care made by medical interaction ifampicin-anticoagulants aggravate the prognostic.
authors.affiliation: Service de pneumologie, hôpital Charles-Nicolle, Tunis, Tunisie. Electronic address: jihenbenamar@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Ben Amar
authors.affiliation: Service de pneumologie, hôpital Charles-Nicolle, Tunis, Tunisie.
authors.forename: B
authors.initials: B
authors.lastname: Dahri
authors.affiliation: Service de pneumologie, hôpital Charles-Nicolle, Tunis, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Aouina
authors.affiliation: Service de pneumologie, hôpital Charles-Nicolle, Tunis, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Bouacha
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D012189:Retrospective Studies; D014397:Tuberculosis, Pulmonary / Q000150:complications*; D014416:Tunisia; D054556:Venous Thromboembolism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D006493:Heparin
keywords: Embolie pulmonaire; Facteurs de risque; Pulmonary embolism; Risk factors; Thrombose veineuse; Tuberculose; Tuberculosis; Venous thrombosis