title: CCR 20th Anniversary Commentary: Chimeric Antigen Receptors-From Model T to the Tesla.
abstract: The research article by Kershaw and colleagues, published in the October 15, 2006, issue of Clinical Cancer Research, presents one of the first clinical trials to utilize chimeric antigen receptors. Subsequent studies have shown promise for the treatment of patients with lymphoid malignancies, but further progress will require optimization, including the identification of more specific antigens for solid tumors.
authors.affiliation: Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. phwu@mdanderson.org.
authors.forename: Patrick
authors.initials: P
authors.lastname: Hwu
mesh_terms: D000846:Anniversaries and Special Events; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007167:Immunotherapy / Q000266:history* / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D011946:Receptors, Antigen / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D011946:Receptors, Antigen