title: Expression of the receptor for advanced glycation end-products and frequency of polymorphism in lung cancer.
abstract: Receptor for advanced glycation end products (RAGE) is associated with the pathogenesis of cancer progression. The pathological effects mediated through RAGE are physiologically inhibited by soluble RAGE (sRAGE). The aim of the present study was to identify the expression of the sRAGE, RAGE and RAGE ligands in serum samples and lung cancer tissue obtained from lung cancer patients. Using ELISA and immunohistochemistry, it was observed that the sRAGE levels were downregulated in the serum, the expression of RAGE was decreased in the lung cancer tissue and the RAGE ligands HMGB1 and S100 were upregulated in cancer tissue. Furthermore, the presence of several selected types of RAGE polymorphism that occur in lung cancers were measured in the tissue samples. An association between the -429T/C and 2184A/G polymorphisms of RAGE and the genesis and progression of lung cancer was identified. The comparison between various histological subtypes and stages of lung cancer was performed with the aim to clarify the biological role of the RAGE gene, and identify a biomarker to aid diagnosis and predict the prognosis for lung cancer patients.
authors.affiliation: Department of Respiratory Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China ; Department of Respiratory Medicine, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Asthma Laboratory, Qingdao Key Laboratory of Common Disease, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
authors.forename: Wencheng
authors.initials: W
authors.lastname: Yu
authors.affiliation: Asthma Laboratory, Qingdao Key Laboratory of Common Disease, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.
authors.forename: Liqing
authors.initials: L
authors.lastname: Ma
authors.affiliation: Asthma Laboratory, Qingdao Key Laboratory of Common Disease, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Respiratory Medicine, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
keywords: RAGE; RAGE polymorphism; lung cancer; soluble RAGE