title: Preventive and Therapeutic Role of Dietary Inositol Supplementation in Periconceptional Period and During Pregnancy: A Summary of Evidences and Future Applications.
abstract: Although inositol dietary deficiency in the general population has not been demonstrated at the serum level, several findings are emerging regarding the impact of inositol supplementation in periconceptional period and in early phases of pregnancy. We are aimed to summarize all experimental (murine in vivo and in vitro murine embryo studies) and clinical (human) evidences regarding the role of inositol in the prevention and treatment of folate-resistant embryo neural tube defects (FR-NTDs) and gestational diabetes mellitus (GDM). We also collected all information regarding the effect that inositol supplementation may have in the metabolic reassessment of early and late pregnancy in order to draw evidence-based conclusions and suggest further studies defining the potential therapeutic role of this molecule in human reproduction. The systematic review of literature clearly showed that inositol supplementation in preconceptional period and in early phase of pregnancy reduces the risk of developing GDM in patients at increased risk. Furthermore, continued intake during pregnancy improves the metabolic status of affected patients, but further studies are needed to confirm this end point. All women at risk of FR-NTDs assuming inositol from the periconceptional period until late pregnancy are reported to have healthy newborns without any significant complications linked to inositol supplementation.
authors.affiliation: Department of Woman and Child Health, University of Padua, Padua, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Noventa
authors.affiliation: Department of Woman and Child Health, University of Padua, Padua, Italy.
authors.forename: Amerigo
authors.initials: A
authors.lastname: Vitagliano
authors.affiliation: Department of Obstetrics and Gynaecology, University of Verona, Verona, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Quaranta
authors.affiliation: Department of Woman and Child Health, University of Padua, Padua, Italy.
authors.forename: Shara
authors.initials: S
authors.lastname: Borgato
authors.affiliation: Department of Obstetrics and Gynecology, NHS Trust, Northampton General Hospital, Northampton, United Kingdom.
authors.forename: Baydaa
authors.initials: B
authors.lastname: Abdulrahim
authors.affiliation: Department of Woman and Child Health, University of Padua, Padua, Italy Department of Obstetrics and Gynecology, NHS Trust, Northampton General Hospital, Northampton, United Kingdom ginecologia_padova@libero.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gizzo
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000008:administration & dosage* / Q000378:metabolism; D009436:Neural Tube Defects / Q000378:metabolism / Q000517:prevention & control*; D016742:Preconception Care / Q000379:methods*; D011247:Pregnancy; D014803:Vitamin B Complex / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D014803:Vitamin B Complex; D007294:Inositol; D005492:Folic Acid
keywords: dietary inositol supplementation; folate resistant neural tube defects.; gestational diabetes; periconceptional period; pregnancy; preventive and therapeutic role