title: Testosterone and Adult Male Bone: Actions Independent of 5α-Reductase and Aromatase.
abstract: Androgens and estrogens influence skeletal development and maintenance in males. However, the relative contributions of the circulating sex steroid hormones that originate from testicular/adrenal secretion versus those produced locally in bone via intracrine action require further elucidation. Our novel hypothesis is that testosterone exerts direct protective effects on the adult male skeleton independently of the actions of 5α-reductase or aromatase.
authors.affiliation: 1Research Service, Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System; 2Departments of Applied Physiology and Kinesiology, and 3Physiological Sciences, University of Florida; and 4Geriatrics Research, Education, and Clinical Center (GRECC), Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL.
authors.forename: Joshua F
authors.initials: JF
authors.lastname: Yarrow
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Wronski
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Borst
mesh_terms: D000375:Aging / Q000378:metabolism; D001141:Aromatase / Q000378:metabolism; D001842:Bone and Bones / Q000201:enzymology / Q000378:metabolism*; D042944:Cholestenone 5 alpha-Reductase / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D004958:Estradiol / Q000096:biosynthesis / Q000378:metabolism; D006801:Humans; D008297:Male; D013739:Testosterone / Q000096:biosynthesis* / Q000172:deficiency / Q000378:metabolism
chemical_list: D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol; D001141:Aromatase; D042944:Cholestenone 5 alpha-Reductase