title: Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons.
abstract: Feature-selective firing allows networks to produce representations of the external and internal environments. Despite its importance, the mechanisms generating neuronal feature selectivity are incompletely understood. In many cortical microcircuits the integration of two functionally distinct inputs occurs nonlinearly through generation of active dendritic signals that drive burst firing and robust plasticity. To examine the role of this processing in feature selectivity, we recorded CA1 pyramidal neuron membrane potential and local field potential in mice running on a linear treadmill. We found that dendritic plateau potentials were produced by an interaction between properly timed input from entorhinal cortex and hippocampal CA3. These conjunctive signals positively modulated the firing of previously established place fields and rapidly induced new place field formation to produce feature selectivity in CA1 that is a function of both entorhinal cortex and CA3 input. Such selectivity could allow mixed network level representations that support context-dependent spatial maps.
authors.affiliation: Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, USA.
authors.forename: Katie C
authors.initials: KC
authors.lastname: Bittner
authors.affiliation: Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Grienberger
authors.affiliation: Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, USA.
authors.forename: Sachin P
authors.initials: SP
authors.lastname: Vaidya
authors.affiliation: Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, USA.
authors.forename: Aaron D
authors.identifier: 0000000271865779
authors.initials: AD
authors.lastname: Milstein
authors.affiliation: Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Macklin
authors.affiliation: 1] RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Howard Hughes Medical Institute at the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: Junghyup
authors.initials: J
authors.lastname: Suh
authors.affiliation: 1] RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Howard Hughes Medical Institute at the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: Susumu
authors.initials: S
authors.lastname: Tonegawa
authors.affiliation: Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, USA.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Magee
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D056654:CA3 Region, Hippocampal / Q000502:physiology*; D018728:Entorhinal Cortex / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology*; D051379:Mice; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology*; D065854:Spatial Navigation / Q000502:physiology*