title: Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans.
abstract: Fungal infections, especially infections caused by Candida albicans, remain a challenging problem in clinical settings. Despite the development of more-effective antifungal drugs, their application is limited for various reasons. Thus, alternative treatments with drugs aimed at novel targets in C. albicans are needed. Knowledge of growth and virulence in fungal cells is essential not only to understand their pathogenic mechanisms but also to identify potential antifungal targets. This article reviews the current knowledge of the mechanisms of growth and virulence in C. albicans and examines potential targets for the development of new antifungal drugs.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong Province, People's Republic of China.
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Cardiology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, People's Republic of China.
authors.forename: Yinglong
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Translational Medicine Research Centre, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, People's Republic of China.
authors.forename: Longtao
authors.initials: L
authors.lastname: Yue
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong Province, People's Republic of China.
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Translational Medicine Research Centre, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Pharmacy, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, People's Republic of China sunshujuan888@163.com.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Sun
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D020013:Calcium Signaling / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D055808:Drug Discovery; D025141:Drug Resistance, Fungal; D015966:Gene Expression Regulation, Fungal; D006038:Glyoxylates / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009994:Osmolar Concentration; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D014774:Virulence
chemical_list: D000935:Antifungal Agents; D006038:Glyoxylates; D010456:Peptides, Cyclic; D014157:Transcription Factors; D058570:TOR Serine-Threonine Kinases; D006867:Hydrolases; C031150:glyoxylic acid