title: Critical Care for Multiple Organ Failure Secondary to Ebola Virus Disease in the United States.
abstract: OBJECTIVE
  This report describes three patients with Ebola virus disease who were treated in the United States and developed for severe critical illness and multiple organ failure secondary to Ebola virus infection. The patients received mechanical ventilation, renal replacement therapy, invasive monitoring, vasopressor support, and investigational therapies for Ebola virus disease.
  
  
  METHODS
  Patient medical records from three tertiary care centers (Emory University Hospital, University of Nebraska Medical Center, and Texas Health Presbyterian Dallas Hospital).
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Not applicable.
  
  
  RESULTS
  Not applicable.
  
  
  CONCLUSIONS
  In the severe form, patients with Ebola virus disease may require life-sustaining therapy, including mechanical ventilation and renal replacement therapy. In conjunction with other reported cases, this series suggests that respiratory and renal failure may occur in severe Ebola virus disease, especially in patients burdened with high viral loads. Ebola virus disease complicated by multiple organ failure can be survivable with the application of advanced life support measures. This collective, multicenter experience is presented with the hope that it may inform future treatment of patients with Ebola virus disease requiring critical care treatment.
authors.affiliation: 1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA. 2Division of Critical Care, Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE. 3Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Texas Health Presbyterian Hospital, Dallas, TX. 4Division of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA. 5Infectious Diseases Institute, Mulago Hospital Complex, Kampala, Uganda. 6Department of Internal Medicine, Division of Infectious Diseases, Texas Health Presbyterian Hospital, Dallas, TX. 7Department of Internal Medicine, Renal Section, Texas Health Presbyterian Hospital, Dallas, TX. 8Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE. 9Department of Internal Medicine, Texas Health Presbyterian Hospital, Dallas, TX.
authors.forename: Viranuj
authors.initials: V
authors.lastname: Sueblinvong
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Johnson
authors.forename: Gary L
authors.initials: GL
authors.lastname: Weinstein
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Connor
authors.forename: Ian
authors.initials: I
authors.lastname: Crozier
authors.forename: Allison M
authors.initials: AM
authors.lastname: Liddell
authors.forename: Harold A
authors.initials: HA
authors.lastname: Franch
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Wall
authors.forename: Andre C
authors.initials: AC
authors.lastname: Kalil
authors.forename: Mark
authors.initials: M
authors.lastname: Feldman
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Lisco
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Sevransky
mesh_terms: D000328:Adult; D003422:Critical Care; D019142:Hemorrhagic Fever, Ebola / Q000150:complications*; D006801:Humans; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology* / Q000628:therapy*; D012720:Severity of Illness Index; D014481:United States