title: CT Perfusion Imaging Can Predict Patients' Survival and Early Response to Transarterial Chemo-Lipiodol Infusion for Liver Metastases from Colorectal Cancers.
abstract: OBJECTIVE
  To prospectively evaluate the performance of computed tomography perfusion imaging (CTPI) in predicting the early response to transarterial chemo-lipiodol infusion (TACLI) and survival of patients with colorectal cancer liver metastases (CRLM).
  
  
  METHODS
  Computed tomography perfusion imaging was performed before and 1 month after TACLI in 61 consecutive patients. Therapeutic response was evaluated on CT scans 1 month and 4 months after TACLI; the patients were classified as responders and non-responders based on 4-month CT scans after TACLI. The percentage change of CTPI parameters of target lesions were compared between responders and non-responders at 1 month after TACLI. The optimal parameter and cutoff value were determined. The patients were divided into 2 subgroups according to the cutoff value. The log-rank test was used to compare the survival rates of the 2 subgroups.
  
  
  RESULTS
  Four-month images were obtained from 58 patients, of which 39.7% were responders and 60.3% were non-responders. The percentage change in hepatic arterial perfusion (HAP) 1 month after TACLI was the optimal predicting parameter (p = 0.003). The best cut-off value was -21.5% and patients who exhibited a ≥ 21.5% decrease in HAP had a significantly higher overall survival rate than those who exhibited a < 21.5% decrease (p < 0.001).
  
  
  CONCLUSIONS
  Computed tomography perfusion imaging can predict the early response to TACLI and survival of patients with CRLM. The percentage change in HAP after TACLI with a cutoff value of -21.5% is the optimal predictor.
authors.affiliation: PET/CT Center, Qilu Hospital, First Affiliated Hospital of Shandong University, Jinan 250012, China. ; Department of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
authors.forename: Wei-Fu
authors.initials: WF
authors.lastname: Lv
authors.affiliation: PET/CT Center, Qilu Hospital, First Affiliated Hospital of Shandong University, Jinan 250012, China.
authors.forename: Jian-Kui
authors.initials: JK
authors.lastname: Han
authors.affiliation: Department of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
authors.forename: De-Lei
authors.initials: DL
authors.lastname: Cheng
authors.affiliation: Department of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
authors.forename: Chun-Ze
authors.initials: CZ
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ni
authors.affiliation: Department of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage; D004998:Ethiodized Oil / Q000008:administration & dosage*; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D011446:Prospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; D004998:Ethiodized Oil
keywords: Colorectal cancer; Computed tomography perfusion imaging; Liver; Metastatic carcinoma; Transarterial chemo-lipiodol infusion