title: Predictors of interest in taking pre-exposure prophylaxis among men who have sex with men who used a rapid HIV-testing site in Montreal (Actuel sur Rue).
abstract: OBJECTIVE
  The effective use of pre-exposure prophylaxis (PrEP) as an HIV prevention strategy depends on its uptake by individuals at high risk of infection. Few Canadian data are available on interest in PrEP among men who have sex with men (MSM). This study aimed to identify predictors of interest in PrEP among MSM clients of a rapid HIV-testing site in Montreal's gay village (Actuel sur Rue).
  
  
  METHODS
  Data were collected using a self-administered and a community agent-administered questionnaire. Among men reporting at least one male sexual partner and visiting the site between July 2012 and November 2013, we aimed to identify sociodemographic, sexual and temporal predictors of interest in taking effective PrEP with logistic regression analyses (univariate and multivariable).
  
  
  RESULTS
  Over half (55%; n = 653) of the sample of 1179 MSM were interested in PrEP. Among the 14 variables considered in the univariate analyses, only (younger) age, (greater) number of sexual partners (in the past 3 months), being part of a serodiscordant couple (in the past 12 months), ever combining sex with drugs and temporal events were associated with interest in PrEP at P < 0.20 and were included in the multivariable analyses. In the multivariable model, only being part of a serodiscordant couple [adjusted odds ratio (aOR) 2.56; 95% confidence interval (CI) 1.44-4.58], having > 10 partners (aOR 1.73; 95% CI 1.17-2.55) and responding after the publication of Quebec's interim PrEP guidelines (aOR 1.82; 95% CI 1.22-2.71) proved significant.
  
  
  CONCLUSIONS
  In this assessment of predictors of PrEP interest among Canadian MSM, partnering issues and the arrival of PrEP guidelines in Quebec (10 July 2013) were most closely linked to PrEP interest.
authors.affiliation: Family Medicine, McGill University, Montreal, QC, Canada.|Chronic Viral Illness Service, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Lebouché
authors.affiliation: Chronic Viral Illness Service, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Engler
authors.affiliation: Clinique médicale l'Actuel, Montreal, QC, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Machouf
authors.affiliation: Family Medicine, McGill University, Montreal, QC, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Lessard
authors.affiliation: Clinique médicale l'Actuel, Montreal, QC, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Thomas
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D002170:Canada / Q000453:epidemiology; D004522:Educational Status; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology; D007722:Health Knowledge, Attitudes, Practice; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010342:Patient Acceptance of Health Care / Q000523:psychology / Q000706:statistics & numerical data*; D065129:Pre-Exposure Prophylaxis / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires; D047568:Unsafe Sex / Q000706:statistics & numerical data*
chemical_list: D019380:Anti-HIV Agents
keywords: Canada; HIV prevention; acceptability; checkpoint; men who have sex with men; pre-exposure prophylaxis