title: Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair.
abstract: OBJECTIVE
  Post-operative stiffness is common after rotator cuff repair, given the difference in susceptibility and severity, the genetic factors may be involved. Interleukin 6 (IL-6) and Matrix metalloproteinases 3 (MMP-3) were previous found as key cytokines in the pathologies of adhesive capsulitis. The present study aims to investigate whether variants within the IL-6 and MMP-3 gene contributed to post-operative stiffness in a Chinese Han population.
  
  
  METHODS
  A total of 188 patients diagnosed with rotator cuff tears treated with mini-open surgery were enrolled in this study, among which 87 patients were diagnosed as post-operative stiffness and the remaining 101 patients as controls. All subjects were genotyped for IL-6 and MMP-3 SNPs.
  
  
  RESULTS
  The rs1800796 of IL-6 and rs679620 of MMP-3 were found significantly associated with increased susceptibility and severity of post-operative stiffness.
  
  
  CONCLUSIONS
  The rs1800796 SNP of IL-6 and rs650108 SNP of MMP-3 were associated with increased risk of post-operative stiffness susceptibility and severity. This finding can be used in guiding the rehabilitation procedure after rotator cuff surgery, in another word, those with the genetic susceptibility factors should receive a more radical rehabilitation procedure and those without the susceptibility factors can be more conservative.
authors.affiliation: Department of Rehabilitation, Qilu Hospital, Shandong University, 44#, Wenhua Xi Road Jinan, 250012, P.R. China ; Research Center of Sports Rehabilitation of Shandong Jinan 250012, Shandong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ling
authors.affiliation: Department of General surgery, Qilu Hospital of Shandong University Jinan 250102, Shandong, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: Research Center of Sports Rehabilitation of Shandong Jinan 250012, Shandong, China.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Research Center of Sports Rehabilitation of Shandong Jinan 250012, Shandong, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation, Qilu Hospital, Shandong University, 44#, Wenhua Xi Road Jinan, 250012, P.R. China.
authors.forename: Shouwei
authors.initials: S
authors.lastname: Yue
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000235:genetics* / Q000534:rehabilitation; D016059:Range of Motion, Articular / Q000235:genetics*; D017006:Rotator Cuff / Q000601:surgery*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3
keywords: IL-6; MMP-3; SNP; postoperative stiffness