title: Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation.
abstract: Smart nanocarriers are of particular interest as nanoscale vehicles of imaging and therapeutic agents in the field of theranostics. Herein, we report dually pH/reduction-responsive terpolymeric vesicles with monodispersive size distribution, which are constructed by assembling acetal- and disulfide-functionalized star terpolymer with near-infrared cyanine dye and anticancer drug. The vesicular nanostructure exhibits multiple theranostic features including on-demand drug releases responding to pH/reduction stimuli, enhanced photothermal conversion efficiency of cyanine dye, and efficient drug translocation from lysosomes to cytoplasma, as well as preferable cellular uptakes and biodistribution. These multiple theranostic features result in ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. The dually stimuli-responsive vesicles represent a versatile theranostic approach for enhanced cancer imaging and therapy.
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Zhu
authors.affiliation: Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, and College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou , Jiangsu 215123, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Miao
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Hengte
authors.initials: H
authors.lastname: Ke
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Guo
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Zhengqing
authors.initials: Z
authors.lastname: Guo
authors.affiliation: School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Yangyun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
authors.affiliation: Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, and College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou , Jiangsu 215123, China.
authors.forename: Youliang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.|School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Huabing
authors.initials: H
authors.lastname: Chen
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers; D065546:Drug Liberation; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced / Q000379:methods; D007208:Indocyanine Green / Q000737:chemistry / Q000494:pharmacology*; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008819:Mice, Nude; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D061848:Optical Imaging / Q000379:methods*; D010084:Oxidation-Reduction; D010316:Particle Size; D055668:Photochemical Processes; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D026082:Singlet Oxygen / Q000378:metabolism; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D004337:Drug Carriers; D005456:Fluorescent Dyes; D011091:Polyesters; D026082:Singlet Oxygen; C016240:polycaprolactone; C052970:poly-N-isopropylacrylamide; D011092:Polyethylene Glycols; D004317:Doxorubicin; D007208:Indocyanine Green
keywords: cancer imaging; photothermal therapy; stimuli-responsive release; synergistic effect; vesicles