title: Polyurethane Microstructures--a Good or Bad in vitro Partner for the Isoflavone Genistein?
abstract: In recent years polyurethane microstructures (PM) have gained increasing attention in the pharmaceutical field due to the importance of their practical application. Since finding that such a formulation with genistein could improve its applications, we have conducted a preliminary study regarding the in vitro antiproliferative (MCF7, MDA-MB-231 and T47D) and antimicrobial (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis (D), Bacillus subtilis, B. cereus, and Candida albicans) activity in order to test whether polyurethane micro structuresre present a good option for further modulation of genistein's bioavailability. It was concluded that the polyurethane micro structures are a bad in vitro partner for the isoflavone genistein.
authors.forename: Corina
authors.initials: C
authors.lastname: Danciu
authors.forename: Florin
authors.initials: F
authors.lastname: Borcan
authors.forename: Codruta
authors.initials: C
authors.lastname: Soica
authors.forename: Istvan
authors.initials: I
authors.lastname: Zupko
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Csányi
authors.forename: Rita
authors.initials: R
authors.lastname: Ambrus
authors.forename: Delia
authors.initials: D
authors.lastname: Muntean
authors.forename: Camelia
authors.initials: C
authors.lastname: Sass
authors.forename: Diana
authors.initials: D
authors.lastname: Antal
authors.forename: Claudia
authors.initials: C
authors.lastname: Toma
authors.forename: Cristina
authors.initials: C
authors.lastname: Dehelean
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D019833:Genistein / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D011140:Polyurethanes; D019833:Genistein