title: Post-Mortem evaluation of amyloid-dopamine terminal positron emission tomography dementia classifications.
abstract: Clinical classification of early dementia and mild cognitive impairment (MCI) is imprecise. We reported previously that molecular imaging classification of early dementia and MCI with dual amyloid and dopamine terminal positron emission tomography differs significantly from expert clinical classification. We now report pathological diagnoses in a substantial subset of our previously imaged subjects. Among 36 subjects coming to autopsy, imaging classifications and pathological diagnosis were concordant in 33 cases (κ = 0.85). This approach enhanced specificity of Alzheimer's disease diagnosis. The strong concordance of imaging-based classifications and pathological diagnoses suggests that this imaging approach will be useful in establishing more accurate and convenient classification biomarkers for dementia research.
authors.affiliation: Neurology Service & GRECC, VAAAHS, Ann Arbor, MI.|Department of Neurology, University of Michigan, Ann Arbor, MI.|Michigan Alzheimer's Disease Center, Ann Arbor, MI.|University of Michigan Morris K. Udall Center of Excellent for Parkinson's Disease Research, Ann Arbor, MI.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Albin
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, MI.
authors.forename: Amanda
authors.initials: A
authors.lastname: Fisher-Hubbard
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, MI.
authors.forename: Krithika
authors.initials: K
authors.lastname: Shanmugasundaram
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Koeppe
authors.affiliation: Neurology Service & GRECC, VAAAHS, Ann Arbor, MI.|Department of Neurology, University of Michigan, Ann Arbor, MI.|Michigan Alzheimer's Disease Center, Ann Arbor, MI.
authors.forename: James F
authors.initials: JF
authors.lastname: Burke
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, MI.
authors.forename: Sandra
authors.initials: S
authors.lastname: Camelo-Piragua
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, MI.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Lieberman
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, MI.
authors.forename: Bruno
authors.initials: B
authors.lastname: Giordani
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, MI.|Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI.
authors.forename: Kirk A
authors.initials: KA
authors.lastname: Frey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D000682:Amyloid / Q000378:metabolism*; D001344:Autopsy; D015415:Biomarkers; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging; D003704:Dementia / Q000145:classification* / Q000000981:diagnostic imaging*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000473:pathology; D049268:Positron-Emission Tomography; D057177:TDP-43 Proteinopathies / Q000473:pathology
chemical_list: D000682:Amyloid; D015415:Biomarkers; D004298:Dopamine