title: Anti-Acetylcholinesterase Alkaloids from Annona glabra Leaf.
abstract: Bioassay guided fractionation and separation of the EtOH extract of Annona glabra leaf against acetylcholinesterse led to the characterization of 15 alkaloids. Among them, (-)-actinodaphnine (2) and (-)-(6aS,7R)-7-hydroxyactinodaphnine (9) are new aporphines, although (+)-2 and (±)-2 have been found in several plants. Their structures were established by spectroscopic analysis. (-)-Anolobine (5) and (-)-roemeroline (8) showed moderate inhibitory activity against eel acetylcholinesterase with IC50 values of 22.4 and 26.3 μM, respectively.
authors.forename: Shoei-Sheng
authors.initials: SS
authors.lastname: Lee
authors.forename: Dong-Yi
authors.initials: DY
authors.lastname: Wu
authors.forename: Sheng-Fa
authors.initials: SF
authors.lastname: Tsai
authors.forename: Chien-Kuang
authors.initials: CK
authors.lastname: Chen
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D031041:Annona / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000470:Alkaloids; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase