title: Challenges and Limits Using Antimicrobial Peptides in Boar Semen Preservation.
abstract: Antibiotics are of great importance for the preservation of ejaculates for livestock breading. The use of antibiotics, however, is not an appropriate compensation for a lack of hygiene standards in artificial insemination (AI) centres. Sophisticated hygiene management and the proper identification of hygienic critical control points (HCCPs) at AI centres provide the basis for counteracting the development of antibiotic resistance in contaminant bacteria and their settlement in AI centres. In recent years, efforts have been made to use antimicrobial peptides (AMPs) in the preservation of boar semen. Investigations have included the testing of synthetic magainin derivatives and cyclic hexapeptides. One prerequisite for the application of AMPs is that they have a minor impact on eukaryotic cells. Bacterial selectivity, proteolytic stability, thermodynamic resistance, and mechanisms including synergistic interaction with conventional antibiotics have made cyclic hexapeptides highly promising candidates for potential application as peptide antibiotics for semen preservation.
authors.affiliation: Institute for the Reproduction of Farm Animals Schönow Inc., Bernau, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schulze
authors.affiliation: Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.|Federal Institute for Risk Assessment, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Grobbel
authors.affiliation: Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Müller
authors.affiliation: Leibniz Institute of Molecular Pharmacology, Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Junkes
authors.affiliation: Leibniz Institute of Molecular Pharmacology, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Dathe
authors.affiliation: Institute for the Reproduction of Farm Animals Schönow Inc., Bernau, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Rüdiger
authors.affiliation: Institute for the Reproduction of Farm Animals Schönow Inc., Bernau, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Jung
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D007315:Insemination, Artificial / Q000662:veterinary; D008297:Male; D010455:Peptides / Q000494:pharmacology; D012661:Semen / Q000382:microbiology; D012662:Semen Preservation / Q000379:methods / Q000662:veterinary*; D013552:Swine; D014982:Xenopus laevis
chemical_list: D000890:Anti-Infective Agents; D010455:Peptides