title: Fetal programming of polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects up to 6.8% of reproductive age women. Experimental research and clinical observations suggest that PCOS may originate in the very early stages of development, possibly even during intrauterine life. This suggests that PCOS is either genetically-transmitted or is due to epigenetic alterations that develop in the intrauterine microenvironment. Although familial cases support the role of genetic factors, no specific genetic pattern has been defined in PCOS. Several candidate genes have been implicated in its pathogenesis, but none can specifically be implicated in PCOS development. Hypotheses based on the impact of the intrauterine environment on PCOS development can be grouped into two categories. The first is the "thrifty" phenotype hypothesis, which states that intrauterine nutritional restriction in fetuses causes decreased insulin secretion and, as a compensatory mechanism, insulin resistance. Additionally, an impaired nutritional environment can affect the methylation of some specific genes, which can also trigger PCOS. The second hypothesis postulates that fetal exposure to excess androgen can induce changes in differentiating tissues, causing the PCOS phenotype to develop in adult life. This review aimed to examine the role of fetal programming in development of PCOS.
authors.affiliation: Esra Bahar Gur, Guluzar Arzu Turan, Department of Obstetrics and Gynecology, Sifa University Faculty of Medicine, Izmir 35100, Turkey.
authors.forename: Esra Bahar
authors.initials: EB
authors.lastname: Gur
authors.affiliation: Esra Bahar Gur, Guluzar Arzu Turan, Department of Obstetrics and Gynecology, Sifa University Faculty of Medicine, Izmir 35100, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Karadeniz
authors.affiliation: Esra Bahar Gur, Guluzar Arzu Turan, Department of Obstetrics and Gynecology, Sifa University Faculty of Medicine, Izmir 35100, Turkey.
authors.forename: Guluzar Arzu
authors.initials: GA
authors.lastname: Turan
keywords: Androgens; Fetal programming; Genetic; Intrauterine growth retardation; Polycystic ovary syndrome