title: Parallel circuits control temperature preference in Drosophila during ageing.
abstract: The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during exposure to cold environments, yet the cellular and molecular mechanisms are not well understood. Here, we identify an age-related change in the temperature preference of adult fruit flies that results from a shift in the relative contributions of two parallel mushroom body (MB) circuits—the β'- and β-systems. The β'-circuit primarily controls cold avoidance through dopamine signalling in young flies, whereas the β-circuit increasingly contributes to cold avoidance as adult flies age. Elevating dopamine levels in β'-afferent neurons of aged flies restores cold sensitivity, suggesting that the alteration of cold avoidance behaviour with ageing is functionally reversible. These results provide a framework for investigating how molecules and individual neural circuits modulate homeostatic alterations during the course of senescence.
authors.affiliation: Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Hsiang-Wen
authors.initials: HW
authors.lastname: Shih
authors.affiliation: 1] Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. [2] Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Wu
authors.affiliation: Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Sue-Wei
authors.initials: SW
authors.lastname: Chang
authors.affiliation: Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Tsung-Ho
authors.initials: TH
authors.lastname: Liu
authors.affiliation: Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Jason Sih-Yu
authors.initials: JS
authors.lastname: Lai
authors.affiliation: Department of Applied Chemistry, National Chi Nan University, Nantou 54561, Taiwan.
authors.forename: Tsai-Feng
authors.initials: TF
authors.lastname: Fu
authors.affiliation: 1] Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan. [2] Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Fu
authors.affiliation: 1] Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan. [2] Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan. [3] Genomics Research Center, Academia Sinica, Nankang, Taipei 11529, Taiwan. [4] Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80780, Taiwan. [5] Kavli Institute for Brain and Mind, University of California at San Diego, La Jolla, California 92093-0526, USA.
authors.forename: Ann-Shyn
authors.initials: AS
authors.lastname: Chiang
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002755:Choice Behavior / Q000502:physiology*; D003080:Cold Temperature; D004298:Dopamine / Q000378:metabolism*; D004331:Drosophila melanogaster; D024521:Mushroom Bodies / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*; D013696:Temperature
chemical_list: D011954:Receptors, Dopamine; D002118:Calcium; D004298:Dopamine