title: Human Parechovirus 3: The Most Common Viral Cause of Meningoencephalitis in Young Infants.
abstract: Human parechoviruses (HPeVs) were initially classified as echoviruses. HPeVs occur worldwide, comprising up to 17 genotypes. HPeV1 and HPeV3 are most common. Clinical disease varies somewhat among genotypes. HPeV1 causes mostly gastrointestinal infections. HPeV3's prominence is due to its causing sepsis syndromes and central nervous system (CNS) infections in young infants. Currently, HPeV3 is the most common single cause of aseptic meningitis/meningoencephalitis in infants less than 90 days old in North America, usually with biannual summer-fall seasonality. HPeV3 CNS infections usually lack cerebrospinal fluid pleocytosis. Mortality and sequelae are uncommon, usually accompanying initially severe or neurologically complicated acute illnesses.
authors.affiliation: Pediatric Infectious Diseases, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, 3175 Ch de la Côte-Sainte-Catherine, Montréal, Québec, Canada.
authors.forename: Christian
authors.initials: C
authors.lastname: Renaud
authors.affiliation: Department of Pediatrics, Children's Mercy Hospitals at Kansas City, University of Missouri-Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA. Electronic address: cjharrison@cmh.edu.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Harrison
mesh_terms: D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D009656:North America / Q000453:epidemiology; D030061:Parechovirus / Q000235:genetics / Q000472:pathogenicity*; D010850:Picornaviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy / Q000821:virology; D012621:Seasons
keywords: Encephalitis; HPeV; Meningitis; Neonate; Seizure; White matter