title: Effects of nocturnal oxygen therapy on heart function in SDB patients undergoing dialysis.
abstract: There is a close relationship between sleep disordered breathing (SDB) and heart failure. We performed home oxygen therapy (HOT) in patients with SAS undergoing dialysis, and investigated its effects on the heart function. The subjects were 10 SDB patients on dialysis. On retiring at night, oxygen was transnasally administered at 1.0 L/min. The human atrial natriuretic peptide (hANP), brain natriuretic peptide (BNP), total protein, Alb, cholesterol and phosphorus levels were measured before the start of oxygen therapy and after 6 weeks. The mean SpO2 increased from 93.5% [91.5, 97.0] to 96.3% [94.8, 97.4] (median [interquartile range]) (p = 0.015). The hANP (p = 0.0039), BNP (p = 0.0098) and serum Alb (p = 0.015) levels significantly improved. There were no significant changes in the cholesterol, phosphorus or total protein levels. These results suggest that nocturnal oxygen therapy improves indices of heart failure, contributing to the prevention and treatment of heart failure in dialysis patients with SDB.
authors.affiliation: a Department of Nephrology , Moriguchi Keijinkai Hospital , Osaka , Japan and.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Nakajima
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Furumatsu
authors.forename: Takatomi
authors.initials: T
authors.lastname: Yurugi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Amari
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iida
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Uehara
authors.forename: Megumu
authors.initials: M
authors.lastname: Fukunaga
mesh_terms: D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010100:Oxygen / Q000008:administration & dosage*; D011788:Quality of Life; D006435:Renal Dialysis / Q000379:methods; D012891:Sleep Apnea Syndromes / Q000097:blood* / Q000150:complications
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D010100:Oxygen
keywords: BNP; SDB; dialysis; hANP; heart failure