title: Melanoma in situ: Part I. Epidemiology, screening, and clinical features.
abstract: The incidence of melanoma has steadily increased over the past 3 decades, with melanoma in situ comprising a disproportionately high percentage of the rising incidence. Our understanding of melanoma in situ has been shaped by epidemiologic and clinical studies. Central to a review of melanoma in situ is a focus on its epidemiology, pathology, biologic behavior, treatment, and clinical outcome, which may differ significantly from that of malignant melanoma. Part I of this continuing medical education article reviews the epidemiology, risk factors, and clinical features of melanoma in situ; part II covers the histopathology, treatment options, and clinical management.
authors.affiliation: Department of Dermatology, Brown University School of Medicine, Providence, Rhode Island. Electronic address: williamhiggins@brown.edu.
authors.forename: H William
authors.initials: HW
authors.lastname: Higgins
authors.affiliation: Department of Dermatology, Brown University School of Medicine, Providence, Rhode Island.
authors.forename: Kachiu C
authors.initials: KC
authors.lastname: Lee
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Anjela
authors.initials: A
authors.lastname: Galan
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: David J
authors.initials: DJ
authors.lastname: Leffell
mesh_terms: D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology; D055088:Early Detection of Cancer / Q000379:methods*; D004502:Education, Medical, Continuing; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology* / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D015995:Prevalence; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology; D014481:United States / Q000453:epidemiology; D000096142:Cutaneous Malignant Melanoma
keywords: lentigo maligna; melanoma; melanoma in situ