title: A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma.
abstract: The importance of enteroscopy examinations to investigate the entire length of the small intestines has been emphasized in follicular lymphoma patients with intestinal involvement. The aim of the present study was to determine the current state of enteroscopy examinations, including the performance rate, and the prevalence of small intestinal lesions in a patient population in Japan. A retrospective multicenter survey of 17 institutions collected the case information of 110 follicular lymphoma patients with gastrointestinal involvement. The results of the enteroscopy examinations were reviewed, and in order to identify potential factors affecting the performance rate of enteroscopy, patient gender, age at lymphoma diagnosis, histopathological grade, clinical stage, the date of the initial diagnosis and the annual volume of enteroscopy at the institution were compared between the patients who underwent one or more enteroscopy procedures and the patients who did not undergo enteroscopy. A total of 34 patients (30.9%) underwent enteroscopy, and 24 of these (70.6%) presented with involvement in the jejunum and/or ileum. It was found that more patients diagnosed in recent years and more patients treated at an ultra-high volume institution (≥101 enteroscopy examinations/year) underwent an enteroscopy. In conclusion, although the prevalence of small intestinal lesions was high (70.6%) in the follicular lymphoma patients presenting with intestinal involvement, the performance rate of enteroscopy was only 30.9%, and thus the majority of the patients have not undergone enteroscopy examinations. Further investigation is required to define the clinical significance of enteroscopy at the initial diagnostic work-up and during the follow-up period of these patients.
authors.affiliation: Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Iwamuro
authors.affiliation: Department of Endoscopy, Okayama University Hospital, Okayama 700-8558, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.affiliation: Department of Endoscopy, Okayama University Hospital, Okayama 700-8558, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawano
authors.affiliation: Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama 700-8511, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Shiode
authors.affiliation: Department of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Takenaka
authors.affiliation: Department of Gastroenterology, Mitoyo General Hospital, Kanonji 769-1695, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Imagawa
authors.affiliation: Department of Gastroenterology, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Inaba
authors.affiliation: Department of Internal Medicine, Sumitomo Besshi Hospital, Niihama 792-8543, Japan.
authors.forename: Seiyu
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Internal Medicine, Okayama City Hospital, Okayama 700-8557, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Nishimura
authors.affiliation: Department of Internal Medicine, Hiroshima City Hospital, Hiroshima 730-8518, Japan.
authors.forename: Motowo
authors.initials: M
authors.lastname: Mizuno
authors.affiliation: Department of Internal Medicine, Kagawa Rosai Hospital, Marugame 763-8502, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Araki
authors.affiliation: Department of Internal Medicine, Chugoku Central Hospital, Fukuyama 720-0001, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Mannami
authors.affiliation: Department of Internal Medicine, Fukuyama City Hospital, Fukuyama 721-8511, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Ueki
authors.affiliation: Department of Hepatology, Japanese Red Cross Okayama Hospital, Okayama 700-8607, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kobashi
authors.affiliation: Department of Internal Medicine, St. Mary's Hospital, Himeji 670-0801, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Fukatsu
authors.affiliation: Department of Gastroenterology, Iwakuni Clinical Center, Iwakuni 740-8510, Japan.
authors.forename: Shouichi
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Department of Internal Medicine, Ako Central Hospital, Ako 678-0241, Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Omoto
authors.affiliation: Department of Gastroenterology, Onomichi Municipal Hospital, Onomichi 722-8503, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Kawai
authors.affiliation: Department of Surgery, Kitagawa Hospital, Okayama 709-0497, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitagawa
authors.affiliation: Department of Gastroenterology, Fukuyama Medical Center, Fukuyama 720-8520, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Toyokawa
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Takata
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Akinobu
authors.initials: A
authors.lastname: Takaki
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
keywords: double-balloon enteroscopy; duodenal neoplasms; intestinal follicular lymphoma; small intestine; video capsule enteroscopy