title: Brief Report: Anal Cancer in the HIV-Positive Population: Slowly Declining Incidence After a Decade of cART.
abstract: We surveyed trends in incidence (1995-2012) and risk factors for anal cancer in the Dutch HIV-positive population. After an initial increase with a peak incidence in 2005-2006 of 114 [95% confidence interval (CI): 74 to 169] in all HIV+ patients and 168 (95% CI: 103 to 259) in HIV+ men who have sex with men (MSM), a decline to 72 (95% CI: 43 to 113) and 100 (95% CI: 56 to 164), respectively, was seen in 2011-2012. Low nadir CD4, alcohol use, and smoking were significantly associated with anal cancer in MSM. In conclusion, anal cancer remains a serious problem in predominantly HIV+ MSM. However, it seems that incidence rates are leveling off.
authors.affiliation: *Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, the Netherlands; †Centre for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; ‡Stichting HIV Monitoring (SHM), Amsterdam, the Netherlands; §Department of Dermatology, Academic Medical Center, Amsterdam, the Netherlands; and ‖STI Outpatient Clinic, Cluster for Infectious Diseases, Public Health Service, Amsterdam, the Netherlands.
authors.forename: Olivier
authors.initials: O
authors.lastname: Richel
authors.forename: Ramon P
authors.initials: RP
authors.lastname: Van Der Zee
authors.forename: Colette
authors.initials: C
authors.lastname: Smit
authors.forename: Henry J C
authors.initials: HJ
authors.lastname: De Vries
authors.forename: Jan M
authors.initials: JM
authors.lastname: Prins
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000150:complications* / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D018451:Homosexuality, Male; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D019380:Anti-HIV Agents