title: Dietary pattern and risk of hodgkin lymphoma in a population-based case-control study.
abstract: Classic Hodgkin lymphoma (cHL) has few known modifiable risk factors, and the relationship between diet and cHL risk is unclear. We performed the first investigation of an association between dietary pattern and cHL risk in 435 cHL cases and 563 population-based controls from Massachusetts and Connecticut (1997-2000) who completed baseline diet questionnaires. We identified 4 major dietary patterns ("vegetable," "high meat," "fruit/low-fat dairy," "desserts/sweets") using principal components analysis. We computed multivariable odds ratios and 95% confidence intervals for associations of dietary pattern score (quartiles) with younger-adult (age <50 years), older-adult (age ≥50 years), and overall cHL risk. Secondary analyses examined associations by histological subtype and tumor Epstein-Barr virus (EBV) status. A diet high in desserts/sweets was associated with younger-adult (odds ratio(quartile 4 vs. quartile 1) = 1.60, 95% confidence interval: 1.05, 2.45; Ptrend = 0.008) and EBV-negative, younger-adult (odds ratio = 2.11, 95% confidence interval: 1.31, 3.41; Ptrend = 0.007) cHL risk. A high meat diet was associated with older-adult (odds ratio = 3.34, 95% confidence interval: 1.02, 10.91; Ptrend = 0.04) and EBV-negative, older-adult (odds ratio = 4.64, 95% confidence interval: 1.03, 20.86; Ptrend = 0.04) cHL risk. Other dietary patterns were not clearly associated with cHL. We report the first evidence for a role of dietary pattern in cHL etiology. Diets featuring high intake of meat or desserts and sweets may increase cHL risk.
authors.forename: Mara M
authors.initials: MM
authors.lastname: Epstein
authors.forename: Ellen T
authors.initials: ET
authors.lastname: Chang
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Teresa T
authors.initials: TT
authors.lastname: Fung
authors.forename: Julie L
authors.initials: JL
authors.lastname: Batista
authors.forename: Richard F
authors.initials: RF
authors.lastname: Ambinder
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Mueller
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Birmann
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003237:Connecticut / Q000453:epidemiology; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D005638:Fruit; D015438:Health Behavior; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D008019:Life Style; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008460:Meat; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012959:Socioeconomic Factors; D014675:Vegetables; D055815:Young Adult
keywords: Hodgkin lymphoma; case-control study; diet; principal components analysis