title: Physiological noise compensation in gradient-echo myelin water imaging.
abstract: In MRI, physiological noise which originates from cardiac and respiratory functions can induce substantial errors in detecting small signals in the brain. In this work, we explored the effects of the physiological noise and their compensation methods in gradient-echo myelin water imaging (GRE-MWI). To reduce the cardiac function induced inflow noise, flow saturation RF pulses were applied to the inferior portion of the head, saturating inflow blood signals. For the respiratory function induced B0 fluctuation compensation, a navigator echo was acquired, and respiration induced phase errors were corrected during reconstruction. After the compensations, the resulting myelin water images show substantially improved image quality and reproducibility. These improvements confirm the importance and usefulness of the physiological noise compensations in GRE-MWI.
authors.affiliation: Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744, Republic of Korea. Electronic address: yhnam83@gmail.com.
authors.forename: Yoonho
authors.initials: Y
authors.lastname: Nam
authors.affiliation: Department of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea. Electronic address: donghyunkim@yonsei.ac.kr.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744, Republic of Korea. Electronic address: jonghoyi@snu.ac.kr.
authors.forename: Jongho
authors.initials: J
authors.lastname: Lee
mesh_terms: D000328:Adult; D016477:Artifacts; D001834:Body Water; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009186:Myelin Sheath; D066127:White Matter / Q000033:anatomy & histology* / Q000737:chemistry; D055815:Young Adult
keywords: B(0) navigator; Flow saturation; MWF; Myelin water imaging; Physiological noise; White matter