title: Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review.
abstract: Hodgkin lymphoma (HL) associated with Warthin tumor (WT) is extremely rare, accounting for only 3 cases of classical HLs. Here, we report for the first time the occurrence of a nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) involving the lymphoid stroma of a WT of the parotid gland. Pathogenesis of WT is controversial, with both a nodal and a parenchymal possible origin. On the other hand, extranodal involvement by HLs is uncommon. In our case, the coexistence of a WT and of a NLPHL within its stroma and in cervical lymph node emphasizes the importance of a careful evaluation of the lymphoid tissue in WT in order to exclude the possibility of an associated lymphoid malignancy.
authors.affiliation: Sant'Andrea Hospital, Sapienza University, Rome, Italy arianna.dinapoli@uniroma1.it.
authors.forename: Arianna
authors.initials: A
authors.lastname: Di Napoli
authors.affiliation: Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mallel
authors.affiliation: Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Bartolazzi
authors.affiliation: Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Cavalieri
authors.affiliation: Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Becelli
authors.affiliation: Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cippitelli
authors.affiliation: Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ruco
mesh_terms: D000235:Adenolymphoma / Q000473:pathology*; D000368:Aged; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010307:Parotid Neoplasms / Q000473:pathology*
keywords: Warthin tumor; collision tumor; nodular predominant Hodgkin lymphoma; parotid gland