title: Hemispheric Asymmetry of Supplementary Motor Area Proper: A Functional Connectivity Study of the Motor Network.
abstract: Cerebral asymmetry is a common feature of human functions. However, there are discrepancies in the literature about functional hemispheric asymmetries in the supplementary motor area (SMA), specifically in the posterior part (SMA-proper). We used resting state functional connectivity MRI to investigate the left-right asymmetries of the functional networks associated with primary motor cortex (M1) and SMA-proper using a "seed"-based correlation analysis in 30 healthy right-handed subjects. We showed that left M1 was more connected with areas involved in the motor system than right M1, and that right SMA-proper had more functional connections than its left counterpart. Our results are in agreement with a leftward asymmetry for M1 connectivity, whereas there is a rightward asymmetry of the SMA-proper connectivity.
authors.affiliation: Département de Médecine Physique et de Réadaptation, Centre Hospitalier Universitaire, Université d'Angers, Angers, France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Dinomais
authors.forename: Eva
authors.initials: E
authors.lastname: Chinier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Richard
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ricalens
authors.forename: Christophe
authors.initials: C
authors.lastname: Aubé
authors.forename: Sylvie
authors.initials: S
authors.lastname: N'Guyen The Tich
authors.forename: Aram
authors.initials: A
authors.lastname: Ter Minassian
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*