title: Perspectives and strategies of alternative methods used in the risk assessment of personal care products.
abstract: Risk assessment for personal care products requires the use of alternative methods since animal testing is now totally banned. Some of these methods are effective and have been validated by the "European Union Reference Laboratory for alternatives to animal testing"; but there is still a need for development and implementation of methods for specific endpoints. In this review, we have focused on dermal risk assessment because it is the prime route of absorption and main target organ for personal care products. Within this field, various areas must be assessed: irritation, sensitisation and toxicokinetic. Personal care product behaviour after use by the consumer and potential effects on the environment are also discussed. The purpose of this review is to show evolution and the prospects of alternative methods for safety dermal assessment. Assessment strategies must be adapted to the different chemical classes of substances studied but also to the way in which they are used. Finally, experimental and theoretical technical parameters that may impact on measured effects have been identified and discussed.
authors.affiliation: Département de toxicologie, Thor Personal Care, 147, rue Irène-Joliot-Curie, 60208 Compiègne cedex, France. Electronic address: paul.quantin@thorpc.fr.
authors.forename: P
authors.initials: P
authors.lastname: Quantin
authors.affiliation: Département de toxicologie, Thor Personal Care, 147, rue Irène-Joliot-Curie, 60208 Compiègne cedex, France. Electronic address: amelie.thelu@thorpc.fr.
authors.forename: A
authors.initials: A
authors.lastname: Thélu
authors.affiliation: Département de toxicologie, Thor Personal Care, 147, rue Irène-Joliot-Curie, 60208 Compiègne cedex, France. Electronic address: sophie.catoire@thorpc.fr.
authors.forename: S
authors.initials: S
authors.lastname: Catoire
authors.affiliation: Département de toxicologie, Thor Personal Care, 147, rue Irène-Joliot-Curie, 60208 Compiègne cedex, France. Electronic address: herve.ficheux@thorpc.fr.
authors.forename: H
authors.initials: H
authors.lastname: Ficheux
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D003358:Cosmetics / Q000009:adverse effects / Q000633:toxicity; D006801:Humans; D018570:Risk Assessment; D017592:Skin Care / Q000009:adverse effects*
chemical_list: D003358:Cosmetics
keywords: Alternative methods; Cosmetics; Cosmétiques; Méthodes alternatives; Peau; Risk assessment; Skin; Toxicologie; Toxicology; Évaluation du risque