title: Incidental detection of prostate-specific antigen-negative metastatic prostate cancer initially presented with solitary pulmonary nodule on fluorodeoxyglucose positron emission tomography/computed tomography.
abstract: A 71-year-old male patient with solitary pulmonary nodule underwent fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) showing slightly increased FDG uptake in this nodule. In addition, PET/CT detected hypermetabolic sclerotic bone lesions in the right second rib and 7(th) thoracic vertebrae, which were interpreted as possible metastases, and mildly increased FDG uptake in the prostate gland highly suspicious of malignancy. The patient's prostate-specific antigen (PSA) level was within normal range (3.8 ng/dL). The histopathological examination of the lung nodule and right second rib lesion proved metastases from prostate cancer, then the prostate biopsy-confirmed prostate adenocarcinoma. The unique feature of this case is to emphasize the importance of performing PET/CT for solitary pulmonary nodule in detecting PSA-negative metastatic prostate cancer. This case indicated that it should be kept in mind that, even if the PSA is negative, a lung metastasis of prostate cancer may be an underlying cause in patients evaluated for solitary pulmonary nodule by FDG PET/CT.
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Bezmialem Vakif University, Turkey.
authors.forename: Ezgi Basak
authors.initials: EB
authors.lastname: Erdogan
authors.affiliation: Department of Pathology, Faculty of Medicine, Bezmialem Vakif University, Turkey.
authors.forename: Nur
authors.initials: N
authors.lastname: Buyukpinarbasili
authors.affiliation: Department of Thoracic Surgery, Faculty of Medicine, Bezmialem Vakif University, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Ziyade
authors.affiliation: Department of Urology, Faculty of Medicine, Bezmialem Vakif University, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Akman
authors.affiliation: Division of Medical Oncology, Faculty of Medicine, Bezmialem Vakif University, Turkey.
authors.forename: Haci Mehmet
authors.initials: HM
authors.lastname: Turk
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Bezmialem Vakif University, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aydin
keywords: Fluorodeoxyglucose positron emission tomography/computed tomography; prostate cancer; solitary pulmonary nodule