title: MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets.
abstract: Cardiovascular diseases (CVDs) have become a predominant cause of death worldwide. Although CVDs encompass a variety of pathological conditions that affect the heart and blood vasculature, they can be classified into two major groups according to their basic pathophysiologic mechanisms, namely atherosclerosis and aneurysm formation. Increasing evidence implicates micro-RNAs (miRNAs or miRs) as vital factors both in the initiation and progression processes of CVDs. Some miRs have a promoting role in CVD development, while others have a protective role. Today, miRs have been shown to be potential biomarkers for several types of CVDs, while strategies targeting miRs are under consideration as potential tools for exploitation in therapeutic approaches for CVD treatments. In this review, we present the available data on the involvement of miRs in CVDs, focusing on their role as regulators of the inflammatory process as an initiating and driving component of CVDs.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Kotsinas
authors.forename: Fragkiska
authors.initials: F
authors.lastname: Sigala
authors.forename: Spiros D
authors.initials: SD
authors.lastname: Garbis
authors.forename: Giorgos
authors.initials: G
authors.lastname: Galyfos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Filis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vougas
authors.forename: Alexandros
authors.initials: A
authors.lastname: Papalampros
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Johnson
authors.forename: Efstathios
authors.initials: E
authors.lastname: Chronopoulos
authors.forename: Alexandros G
authors.initials: AG
authors.lastname: Georgakilas
authors.affiliation: Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece; and Cancer and Clinical Experimental Science Units, Faculty of Medicine, Institute for Life Sciences, Center for Proteome Research, University of Southampton, Southampton, UK. vgorg@med.uoa.gr.
authors.forename: Vassilis G
authors.initials: VG
authors.lastname: Gorgoulis
mesh_terms: D000783:Aneurysm / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation; D007962:Leukocytes / Q000166:cytology / Q000473:pathology; D035683:MicroRNAs / Q000097:blood* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C524940:MIRN21 microRNA, human; D035683:MicroRNAs