title: Reversible dementia: two nursing home patients with voltage-gated potassium channel antibody-associated limbic encephalitis.
abstract: Voltage-gated potassium channel antibody-associated limbic encephalitis (VGKC-LE) is a rare disease that is a diagnostic and therapeutic challenge for medical practitioners. Two patients with VGKC-LE, both developing dementia are presented. Following treatment, both patients showed remarkable cognitive and functional improvement enabling them to leave the psychogeriatric nursing homes they both were admitted to. Patients with VGKC-LE can have a major cognitive and functional improvement even after a diagnostic delay of more than 1 year. Medical practitioners who treat patients with unexplained cognitive decline, epileptic seizures, or psychiatric symptoms should be aware of LE as an underlying rare cause.
authors.affiliation: Department of Geriatric Medicine, Jeroen Bosch ziekenhuis, Den Bosch, The Netherlands.
authors.forename: Wesley
authors.initials: W
authors.lastname: Reintjes
authors.affiliation: Department of Geriatric Medicine, Jeroen Bosch ziekenhuis, Den Bosch, The Netherlands.
authors.forename: Marloes D M
authors.initials: MD
authors.lastname: Romijn
authors.affiliation: Department of Internal Medicine, Jeroen Bosch ziekenhuis, Den Bosch, The Netherlands.
authors.forename: Daan
authors.initials: D
authors.lastname: Hollander
authors.affiliation: Department of Neurology, Jeroen Bosch ziekenhuis, Den Bosch, The Netherlands.
authors.forename: Jan P
authors.initials: JP
authors.lastname: Ter Bruggen
authors.affiliation: Department of Geriatric Medicine, Jeroen Bosch ziekenhuis, Den Bosch, The Netherlands; Department of General Practice and Elderly Care Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands. Electronic address: R.v.Marum@jbz.nl.
authors.forename: Rob J
authors.initials: RJ
authors.lastname: van Marum
mesh_terms: D000368:Aged; D057210:Delayed Diagnosis; D003704:Dementia / Q000209:etiology*; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D009483:Neuropsychological Tests; D009735:Nursing Homes; D024642:Potassium Channels, Voltage-Gated
chemical_list: D024642:Potassium Channels, Voltage-Gated
keywords: Limbic encephalitis; VGKC; dementia