title: Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis.
abstract: Actinic cheilitis (AC) is a common premalignant condition that requires an effective treatment to reduce the risk of malignant transformation. Photodynamic therapy (PDT) has been recently added to the armamentarium available for AC treatment. Daylight PDT (D-PDT) is a novel PDT modality in which the activation of the topical photosensitizer is induced by the exposure to natural daylight instead of artificial light sources without preliminary occlusion. This simplified procedure was found to be more tolerated as compared to conventional PDT. We report our preliminary experience on the use of D-PDT using methyl-aminolevulinate cream in 10 patients with refractory AC of the lower lip. Patients received two consecutive D-PDT sessions with an interval of 7-14 days. At 3 months after therapy, a complete response was observed in seven patients, with sustained results in five patients over an observational period of 6-12 months. Treatment was well tolerated.
authors.affiliation: Phototherapy Unit-Dermatology Service, AUSL LECCE, Salento, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Fai
authors.affiliation: Phototherapy Unit-Dermatology Service, AUSL LECCE, Salento, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Romanello
authors.affiliation: Dermatology Unit, Department of Dermatology, University of Padua, Padua, Italy.
authors.forename: Marta Benedetta
authors.initials: MB
authors.lastname: Brumana
authors.affiliation: Phototherapy Unit-Dermatology Service, AUSL LECCE, Salento, Italy.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Fai
authors.affiliation: Dermatology and Venereology Private Practice, Bari and Barletta, Italy.
authors.forename: Gino Antonio
authors.initials: GA
authors.lastname: Vena
authors.affiliation: Dermatology and Venereology Private Practice, Bari and Barletta, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Cassano
authors.affiliation: Dermatology Unit, Department of Dermatology, University of Padua, Padua, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Piaserico
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D002613:Cheilitis / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000009:adverse effects; D012074:Remission Induction; D012189:Retrospective Studies; D063465:Skin Cream; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; C475457:methyl 5-aminolevulinate; D000622:Aminolevulinic Acid
keywords: actinic cheilitis; daylight photodynamic therapy; methyl-aminolevulinate; neoplasms-malignant; phototherapy; therapy-topical