title: A 4-year follow-up of living unrelated donors of kidney allograft in Iran.
abstract: BACKGROUND
  Shortage of deceased donor kidneys has resulted in an increased rate of kidney transplantation from living unrelated donors (LURDs). However, there are concerns about short-term and long-term morbidity of the donors. This study reports the clinical and biochemical factors in a follow-up program of Iranian LURDs, one of the largest reported series of kidney donors.
  
  
  METHODS
  Of 7500 individuals who underwent living donor nephrectomies between 2005 and 2008, a total of 1549 participated in this study. They were followed for 18 to 48 months after the kidney donation. The average time for the first study visit was 316.72 days after donation.
  
  
  RESULTS
  The mean age of donors was 30.43 ± 6.16 years old. Men consisted 82.5% of the group. Systolic hypertension was detected in 0.2% and diastolic hypertension in 1% of the LURDs; however, anemia prevalence was as high as 47.2%. Hyperuricemia was found in 21.2% of the LURDs, while proteinuria was seen in 13.7%. Glomerular filtration rate was greater than 90 mL/min in 38.2% of the donors, 60 mL/min to 90 mL/min in 54.5%, and less than 60 mL/min in 7.3%. A GFR less than 45 mL/min was seen in 0.1% of the donors.
  
  
  CONCLUSIONS
  Data suggested that the LURDs in Iran have an appropriate health condition comparable to other donors in other parts of the world. Considering the high prevalence of hyperuricemia in our population and its importance as a risk factor for kidney failure, monitoring serum uric acid in follow-up programs is suggested.
authors.forename: Ali
authors.initials: A
authors.lastname: Nobakht Haghighi
authors.affiliation: Hasheminejad Clinical Research Development Center, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran. tahereh.malakoutian@hkc.ir.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Malakoutian
authors.forename: Mohammadhadi
authors.initials: M
authors.lastname: Radfar
authors.forename: Ezatollah
authors.initials: E
authors.lastname: Abdi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kamgar
authors.forename: Behrooz
authors.initials: B
authors.lastname: Broumand
authors.forename: Iradj
authors.initials: I
authors.lastname: Fazel
mesh_terms: D000328:Adult; D064591:Allografts; D000740:Anemia / Q000453:epidemiology*; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007492:Iran; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects*; D011183:Postoperative Complications; D011507:Proteinuria / Q000453:epidemiology*; D012307:Risk Factors; D061349:Unrelated Donors; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D014527:Uric Acid; D003404:Creatinine