title: Energy intake, nonexercise physical activity, and weight loss in responders and nonresponders: The Midwest Exercise Trial 2.
abstract: OBJECTIVE
  To compare energy intake, total daily energy expenditure (TDEE), nonexercise energy expenditure (NEEx), resting metabolic rate (RMR), nonexercise physical activity (NEPA), and sedentary time between participants with weight loss <5% (nonresponders) vs. ≥5% (responders) in response to exercise.
  
  
  METHODS
  Adults (18-30 years) with overweight/obesity (BMI 25-40 kg/m(2) ) were randomized to exercise: 5 days/week, 400 or 600 kcal/session, 10 months.
  
  
  RESULTS
  Of the participants, 40 responded and 34 did not respond to the exercise protocol. Nonresponder energy intake was higher vs. responders, significant only in men (P=0.034). TDEE increased only in responders (P=0.001). NEEx increased in responders and decreased in nonresponders, significant only in men (P=0.045). There were no within- or between-group differences for change in RMR. NEPA increased in responders and decreased in nonresponders (group-by-time interactions: total sample, P=0.049; men, P=0.016). Sedentary time decreased in both groups, significant only in men.
  
  
  CONCLUSIONS
  Men who did not lose weight in response to exercise (<5%) had higher energy intake and lower NEEx when compared with men losing ≥5%. No significant differences in any parameters assessed were observed between women who lost <5% vs. those losing ≥5%. Factors associated with the weight loss response to exercise in women warrant additional investigation.
authors.affiliation: Center for Health Outcomes & Prevention Research, Sanford Research, Sioux Falls, South Dakota, USA.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Herrmann
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, The University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Erik A
authors.initials: EA
authors.lastname: Willis
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, The University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Jeffery J
authors.initials: JJ
authors.lastname: Honas
authors.affiliation: Institute for Measurement, Methodology, Analysis, and Policy, Texas Tech University, Lubbock, Texas, USA.
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, The University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Washburn
authors.affiliation: Department of Internal Medicine, Cardiovascular Research Institute, The University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Donnelly
mesh_terms: D000293:Adolescent; D000328:Adult; D002149:Energy Intake / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007615:Kansas; D008297:Male; D009765:Obesity / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult