title: Orthodontic bracket bonding without previous adhesive priming: A meta-regression analysis.
abstract: OBJECTIVE
  To determine the consensus among studies that adhesive resin application improves the bond strength of orthodontic brackets and the association of methodological variables on the influence of bond strength outcome.
  
  
  METHODS
  In vitro studies were selected to answer whether adhesive resin application increases the immediate shear bond strength of metal orthodontic brackets bonded with a photo-cured orthodontic adhesive. Studies included were those comparing a group having adhesive resin to a group without adhesive resin with the primary outcome measurement shear bond strength in MPa. A systematic electronic search was performed in PubMed and Scopus databases.
  
  
  RESULTS
  Nine studies were included in the analysis. Based on the pooled data and due to a high heterogeneity among studies (I(2)  =  93.3), a meta-regression analysis was conducted. The analysis demonstrated that five experimental conditions explained 86.1% of heterogeneity and four of them had significantly affected in vitro shear bond testing. The shear bond strength of metal brackets was not significantly affected when bonded with adhesive resin, when compared to those without adhesive resin.
  
  
  CONCLUSIONS
  The adhesive resin application can be set aside during metal bracket bonding to enamel regardless of the type of orthodontic adhesive used.
authors.affiliation: a  MSc student, Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Aline Segatto Pires
authors.initials: AS
authors.lastname: Altmann
authors.affiliation: b  PhD student, Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Felipe Weidenbach
authors.initials: FW
authors.lastname: Degrazia
authors.affiliation: c  Associate Professor, Department of Preventive and Social Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Roger Keller
authors.initials: RK
authors.lastname: Celeste
authors.affiliation: d  Associate Professor, Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Vicente Castelo Branco
authors.initials: VC
authors.lastname: Leitune
authors.affiliation: f  Chair Professor, Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Susana Maria Werner
authors.initials: SM
authors.lastname: Samuel
authors.affiliation: e  Associate Professor, Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Fabrício Mezzomo
authors.initials: FM
authors.lastname: Collares
mesh_terms: D000134:Acid Etching, Dental; D001840:Dental Bonding; D003738:Dental Cements; D003799:Dental Stress Analysis; D006801:Humans; D008422:Materials Testing; D016910:Orthodontic Brackets; D012044:Regression Analysis; D019279:Resin Cements; D033081:Shear Strength
chemical_list: D003738:Dental Cements; D019279:Resin Cements
keywords: Dental bonding; Orthodontic brackets; Shear strength