title: Serum nectin-2 levels are diagnostic and prognostic in patients with colorectal carcinoma.
abstract: BACKGROUND
  Nectins are a family of integral protein and immunoglobulin-like cell adhesion molecules involved in the formation of functioning adherence and tight junctions. Aberrant expression is associated with cancer progression, apoptosis and cell proliferation but little is known how these effects change in cell behavior. The objective of this study was to evaluate the serum levels of nectin-2 with regard to diagnostic, predictive and prognostic value in colorectal cancer (CRC) patients.
  
  
  METHODS
  One-hundred and forty CRC patients were enrolled in this study. Serum nectin-2 levels were determined by enzyme-linked immunosorbent assay method. Age- and sex-matched 40 healthy controls were included in the analysis.
  
  
  RESULTS
  Median age of patients was 60 years old, range 24-84 years. The localization of tumor in majority of the patients was colon (n = 81, 58 %). Non-metastatic (stage II and III) and metastatic patients' baseline serum nectin-2 levels were significantly higher than those in the healthy control group (p < 0.001; for two group). However, known clinical variables including response to CTx (chemotherapy) were not found to be correlated with serum nectin-2 concentrations (p > 0.05). While non-metastatic group patients with elevated serum nectin-2 levels showed significant adverse effect on PFS, metastatic group patients with elevated serum nectin-2 levels showed no significant adverse effect on PFS (p = 0.05 and p = 0.29, respectively). On the other hand, our study results did not show statistically significant serum nectin-2 concentrations regarding overall survival rates.
  
  
  CONCLUSIONS
  Serum levels of nectin-2 may have diagnostic roles for CRC patients. Moreover, our study results show the prognostic role of nectin-2 in non-metastatic group patients.
authors.affiliation: Clinic of General Surgery, Istanbul Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Karabulut
authors.affiliation: Clinic of Medical Oncology, Istanbul Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Gunaldi
authors.affiliation: Clinic of General Surgery, Istanbul Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Alis
authors.affiliation: Department of Medical Oncology, Ministry of Health, Istanbul Training and Research Hospital, Istanbul, Turkey. cigdemusul@yahoo.com.
authors.forename: C U
authors.initials: CU
authors.lastname: Afsar
authors.affiliation: Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Karabulut
authors.affiliation: Department of Basic Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Serilmez
authors.affiliation: Clinic of General Surgery, Istanbul Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Akarsu
authors.affiliation: Clinic of General Surgery, Istanbul Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Seyit
authors.affiliation: Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
authors.forename: N F
authors.initials: NF
authors.lastname: Aykan
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D000075983:Nectins; D011379:Prognosis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D000075983:Nectins
keywords: Colorectal cancer; Diagnostic; Nectin-2; Prognostic; Progression-free survival; Serum