title: Effect of substituted stilbenes on platelet function.
abstract: Stilbenes, including resveratrol, are polyphenols provided with protective actions on the cardiovascular system. Some natural derivatives of resveratrol, like pterostilbene, have a better bioavailability than the parent compound. The aim of the present study was to prepare different substituted stilbenes (dimethylallyloxy-stilbene, dimethylallyloxy-pterostilbene) and compare them with resveratrol, p-hydroxy-stilbene and pterostilbene for their biologic activities on platelet aggregation, platelet radical oxygen species (ROS) production, and platelet nitric oxide (NO) synthesis. The results show that the increase of stilbene derivative lipophilicity enhances their biologic activities.
authors.affiliation: Department of Pharmaceutical Sciences, Section of Public Health, University of Perugia, via del, Liceo, 1, 06123 Perugia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Messina
authors.affiliation: Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, via E. dal Pozzo, 06126 Perugia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Guglielmini
authors.affiliation: Department of Pharmaceutical Sciences, Section of Public Health, University of Perugia, via del, Liceo, 1, 06123 Perugia, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.affiliation: Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, via E. dal Pozzo, 06126 Perugia, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Orsini
authors.affiliation: Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, via E. dal Pozzo, 06126 Perugia, Italy. Electronic address: paolo.gresele@unipg.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gresele
authors.affiliation: Department of Pharmaceutical Sciences, Section of Public Health, University of Perugia, via del, Liceo, 1, 06123 Perugia, Italy.
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Marcotullio
mesh_terms: D001792:Blood Platelets / Q000187:drug effects*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D017382:Reactive Oxygen Species; D013267:Stilbenes; D009569:Nitric Oxide; D000077185:Resveratrol
keywords: Dimethylallyloxy-stilbene; Platelet NOx production; Platelet ROS production; Platelet aggregation; Resveratrol