title: Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women.
abstract: OBJECTIVE
  Previous studies regarding the effect of obesity on serum anti-müllerian hormone (AMH) levels have been conflicting. Our aim was to determine the effect of obesity on serum AMH levels among women from different racial backgrounds.
  
  
  METHODS
  The medical records of 350 women (159 Caucasian, 99 African-American, 58 Hispanic, 34 Asian with ages 16-46) evaluated for infertility at an academic-affiliated center and who had AMH levels measured as part of their evaluation were reviewed. Age, AMH, body mass index (BMI), self-reported race, etiology of infertility, smoking history, maximum serum early follicular follicle-stimulating hormone (FSH) levels, antral follicle count (AFC), and history of ovarian surgery, chemotherapy, or radiotherapy were recorded.
  
  
  RESULTS
  Age correlated negatively with AMH and antral follicle count across all races (p < 0.05). After adjusting for age, polycystic ovary syndrome diagnosis, and smoking, elevated BMI had a negative correlation with AMH in Caucasian women (β = 0.17, p = 0.01) but not in African-American, Hispanic, or Asian women.
  
  
  CONCLUSIONS
  Elevated BMI correlates negatively with AMH in Caucasian women but not in African-American, Hispanic, or Asian women. Additional studies are needed to elucidate further the effect of race on the interaction between obesity and ovarian reserve.
authors.affiliation: Department of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Block Building Room 630, Bronx, NY, 10461, USA.
authors.forename: Vicky
authors.initials: V
authors.lastname: Moy
authors.affiliation: Department of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Block Building Room 630, Bronx, NY, 10461, USA.|Montefiore's Institute for Reproductive Medicine and Health, Hartsdale, NY, USA.
authors.forename: Sangita
authors.initials: S
authors.lastname: Jindal
authors.affiliation: Department of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Block Building Room 630, Bronx, NY, 10461, USA.|Montefiore's Institute for Reproductive Medicine and Health, Hartsdale, NY, USA.
authors.forename: Harry
authors.initials: H
authors.lastname: Lieman
authors.affiliation: Department of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Block Building Room 630, Bronx, NY, 10461, USA. erbuyuk@yahoo.com.|Montefiore's Institute for Reproductive Medicine and Health, Hartsdale, NY, USA. erbuyuk@yahoo.com.
authors.forename: Erkan
authors.initials: E
authors.lastname: Buyuk
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000208:ethnology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000208:ethnology / Q000503:physiopathology; D011247:Pregnancy; D011379:Prognosis; D012907:Smoking / Q000009:adverse effects; D044465:White People / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: Anti-müllerian hormone (AMH); Body mass index; Obesity; Race/ethnicity