title: Ultratrace Measurement of Acetone from Skin Using Zeolite: Toward Development of a Wearable Monitor of Fat Metabolism.
abstract: Analysis of gases emitted from human skin and contained in human breath has received increasing attention in recent years for noninvasive clinical diagnoses and health checkups. Acetone emitted from human skin (skin acetone) should be a good indicator of fat metabolism, which is associated with diet and exercise. However, skin acetone is an analytically challenging target because it is emitted in very low concentrations. In the present study, zeolite was investigated for concentrating skin acetone for subsequent semiconductor-based analysis. The adsorption and desorption characteristics of five zeolites with different structures and those hydrophobicities were compared. A hydrophobic zeolite with relatively large pores (approximately 1.6 times larger than the acetone molecule diameter) was the best concentrator of skin acetone among the zeolites tested. The concentrator developed using zeolite was applied in a semiconductor-based gas sensor in a simulated mobile environment where the closed space was frequently collapsed to reflect the twisting and elastic movement of skin that would be encountered in a wearable device. These results could be used to develop a wearable analyzer for skin acetone, which would be a powerful tool for preventing and alleviating lifestyle-related diseases.
authors.affiliation: †Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.|‡Research Laboratories, NTT DOCOMO, Inc., 3-6 Hikarinooka, Yokosuka, Kanagawa 239-8536, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: ‡Research Laboratories, NTT DOCOMO, Inc., 3-6 Hikarinooka, Yokosuka, Kanagawa 239-8536, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hiyama
authors.affiliation: ‡Research Laboratories, NTT DOCOMO, Inc., 3-6 Hikarinooka, Yokosuka, Kanagawa 239-8536, Japan.
authors.forename: Tsuguyoshi
authors.initials: T
authors.lastname: Toyooka
authors.affiliation: §Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Takeuchi
authors.affiliation: ∥Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Itabashi
authors.affiliation: ∥Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okubo
authors.affiliation: †Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tabata
mesh_terms: D000096:Acetone / Q000032:analysis*; D000327:Adsorption; D001944:Breath Tests / Q000379:methods*; D006801:Humans; D057230:Limit of Detection; D050356:Lipid Metabolism; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods*; D016062:Porosity; D012867:Skin / Q000737:chemistry*; D017641:Zeolites / Q000737:chemistry*
chemical_list: D017641:Zeolites; D000096:Acetone