title: Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus.
abstract: Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.
authors.affiliation: Department of Natural Product Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. cuiyanmei11@gmail.com.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Natural Product Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. taniguchi@pharm.okayama-u.ac.jp.
authors.forename: Shoko
authors.initials: S
authors.lastname: Taniguchi
authors.affiliation: Drug Discovery Technology Center, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. tkuroda@cc.okayama-u.ac.jp.
authors.forename: Teruo
authors.initials: T
authors.lastname: Kuroda
authors.affiliation: Department of Natural Product Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. hatano@pharm.okayama-u.ac.jp.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hatano
mesh_terms: D000085:Acetates; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002850:Chromatography, Gel; D005638:Fruit / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029907:Psoralea / Q000737:chemistry*; D012997:Solvents; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D047188:Chalcones; D010636:Phenols; D012997:Solvents; C468754:isobavachalcone; C007650:ethyl acetate; C012765:bakuchiol
keywords: Psoralea corylifolia; bakuflavanone; bakuisoflavone; methicillin-resistant Staphylococcus aureus