title: Is Risk Malignancy Index a Useful Tool for Predicting Malignant Ovarian Masses in Developing Countries?
abstract: Introduction. Risk of Malignancy Index (RMI) is widely studied for prediction of malignant pelvic masses in Western population. However, little is known regarding its implication in the developing countries. The objective of this study is to determine how accurately the RMI can predict the malignant pelvic masses. Materials and Methods. The study is a retrospective review of patients attending the gynecological clinic between January 2004 and December 2008 with adnexal masses. Information on demographic characteristics, ultrasound findings, menopausal status, CA125, and histopathology was collected. RMI score for each patient in the study group was calculated. Results. The study group included a total of 283 patients. Analysis of the individual parameters of RMI revealed that ultrasound was the best predictor of malignancy with a sensitivity, specificity, and positive likelihood ratio of 78.3%, 81.5%, and 4.2, respectively. At a standard cut-off value of 250, RMI had a positive likelihood ratio of 8.1, while it was 6.8 at a cut-off of 200, albeit with comparable sensitivity and specificity. Conclusion. RMI is a sensitive tool in predicting malignant adnexal masses. A cut-off of 200 may be suitable in developing countries for triaging and early referral to tertiary care centers.
authors.affiliation: Department of Obstetrics and Gynaecology, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Aliya B
authors.initials: AB
authors.lastname: Aziz
authors.affiliation: Department of Obstetrics and Gynaecology, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Nida
authors.initials: N
authors.lastname: Najmi