title: Evaluation of relationship between GRM3 polymorphisms and cognitive function in schizophrenia of Han Chinese.
abstract: Recently, the novel SNP rs12704290 in GRM3 was identified in a genome-wide association study on schizophrenia susceptibility. Our study was to investigate the association of 29 selected SNPs (including rs12704290) with schizophrenia and to evaluate any possible relationship between them and cognition related to schizophrenia. The SNPs were analyzed in 1115 unrelated schizophrenic patients and 2289 healthy controls. The results showed significant associations between these SNPs and schizophrenia as well as with changes in cognition.
authors.affiliation: School of Management, Xi'an Jiaotong University, Xi'an, China; School of Psychology, Shaanxi Normal University, Xi'an, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Chang
authors.affiliation: School of Management, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Linyan
authors.initials: L
authors.lastname: Sun
authors.affiliation: School of Management, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Xinmei
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Management, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: School of Psychology, Shaanxi Normal University, Xi'an, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ji
authors.affiliation: School of Psychology, Shaanxi Normal University, Xi'an, China.
authors.forename: Zhenhong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Psychology, Shaanxi Normal University, Xi'an, China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Psychology, Shaanxi Normal University, Xi'an, China. Electronic address: sms1226moon@icloud.com.
authors.forename: Xuqun
authors.initials: X
authors.lastname: You
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003071:Cognition; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D020033:Protein Isoforms / Q000235:genetics; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D020033:Protein Isoforms; D018094:Receptors, Metabotropic Glutamate; C102718:metabotropic glutamate receptor 3
keywords: Cognitive function; Glutamate receptor; Schizophrenia susceptibility