title: Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes.
abstract: OBJECTIVE
  The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population.
  
  
  METHODS
  We designed a case-control study involving 340 normal glucose tolerant (NGT) subjects and 340 type 2 diabetes patients. Three SNPs (rs182052, rs1501299, and rs7627128) were genotyped by TaqMan methods.
  
  
  RESULTS
  We found that rs7627128, rs1501299 and rs182052 were significantly associated with T2DM. Haplotypes analysis indicated that the frequency of the haplotypes A-A-T was frequent in T2DM patients (OR = 2.10; 95%CI: 1.44-2.90; p < 0.001), but G-A-T was more frequent in the control group than in the T2DM group (OR = 0.66; 95%CI: 0.54-0.81; p < 0.001).
  
  
  CONCLUSIONS
  The ADIPOQ genetic polymorphisms were associated with type 2 diabetes in a Chinese population.
authors.affiliation: Golden Card Hospital, West China Hospital, Sichuan University, Chengdu 610041, China. zhilipengirl@126.com.
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Li
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. zhangmaile@163.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China. gaozhjiear@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China. zhougirlyan@126.com.
authors.forename: Guo-Yan
authors.initials: GY
authors.lastname: Zhou
authors.affiliation: Golden Card Hospital, West China Hospital, Sichuan University, Chengdu 610041, China. lishuangqing201@yeah.net.
authors.forename: Shuang-Qing
authors.initials: SQ
authors.lastname: Li
authors.affiliation: Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China. anzhemaile@yeah.net.
authors.forename: Zhen-Mei
authors.initials: ZM
authors.lastname: An
keywords: ADIPOQ; case-control study; genetic polymorphism; type 2 diabetes