title: Skin Stem Cells: At the Frontier Between the Laboratory and Clinical Practice. Part 1: Epidermal Stem Cells.
abstract: Stem cells are characterized by their ability to self-renew and differentiate into the different cell lineages of their tissue of origin. The discovery of stem cells in adult tissues, together with the description of specific markers for their isolation, has opened up new lines of investigation, expanding the horizons of biomedical research and raising new hope in the treatment of many diseases. In this article, we review in detail the main characteristics of the stem cells that produce the specialized cells of the skin (epidermal, mesenchymal, and melanocyte stem cells) and their potential implications and applications in diseases affecting the skin. Part I deals with the principal characteristics and potential applications of epidermal stem cells in dermatology.
authors.affiliation: Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB), Bruselas, Bélgica. Electronic address: jane.pastushenko@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Pastushenko
authors.affiliation: Servicio de Dermatología, Hospital Clínico Lozano Blesa, Zaragoza, España.
authors.forename: L
authors.initials: L
authors.lastname: Prieto-Torres
authors.affiliation: Servicio de Dermatología, Hospital San Jorge, Huesca, España; Instituto Aragonés de Ciencias de la Salud, Zaragoza, España.
authors.forename: Y
authors.initials: Y
authors.lastname: Gilaberte
authors.affiliation: Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB), Bruselas, Bélgica; Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Université Libre de Bruxelles (ULB), Bruselas, Bélgica.
authors.forename: C
authors.initials: C
authors.lastname: Blanpain
mesh_terms: D053687:Adult Stem Cells / Q000145:classification / Q000166:cytology*; D000818:Animals; D002056:Burns / Q000601:surgery; D002454:Cell Differentiation; D019070:Cell Lineage; D000066673:Cell Self Renewal; D002921:Cicatrix / Q000473:pathology; D000078404:Epidermal Cells; D005544:Forecasting; D015316:Genetic Therapy / Q000379:methods; D018859:Hair Follicle / Q000166:cytology; D006706:Homeostasis; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D012627:Sebaceous Glands / Q000166:cytology; D012878:Skin Neoplasms / Q000473:pathology; D033581:Stem Cell Transplantation
keywords: Adult stem cells; Aplicaciones terapéuticas; Células madre del adulto; Células madre epidérmicas; Dermatology; Dermatología; Epidermal stem cells; Review; Revisión; Therapeutic applications