title: A new flavonol glycoside from the florets of Carthamus tinctorius L.
abstract: One new flavonol glycoside, 6-hydroxykaempferol-3-O-β-D-glucoside-7-O-β-D-glucuronide (1), together with eight known flavonoids and three known quinochalcones, was isolated from the florets of Carthamus tinctorius L. Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against H2O2-induced apoptosis in H9c2 cells were also evaluated; compounds 1, 2, 4-5, 7-10 and 12 provided significant protective effects on H2O2-induced H9c2 cells at the concentration of 25 μg/mL.
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Xie
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Zhou
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Hongda
authors.initials: H
authors.lastname: Zhang
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Yiwu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Song
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Fuyong
authors.initials: F
authors.lastname: Ni
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Huang
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a Jiangsu Kanion Pharmaceutical Co., Ltd , Jiangsu, Lianyungang 222001 , P.R. China.|b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Jiangsu, Lianyungang 222001 , P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002316:Cardiotonic Agents / Q000737:chemistry / Q000494:pharmacology; D031187:Carthamus tinctorius / Q000737:chemistry*; D002460:Cell Line / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D044948:Flavonols / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D044949:Kaempferols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: C000609495:6-hydroxykaempferol-3-O-beta-D-glucoside-7-O-beta-D-glucuronide; D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D044948:Flavonols; D005960:Glucosides; D006027:Glycosides; D044949:Kaempferols; D006861:Hydrogen Peroxide
keywords: 6-hydroxykaempferol-3-O-β-D-glucoside-7-O-β-D-glucuronide; Carthamus tinctorius L; cardioprotective activitiy