title: New insights into the conserved mechanism of pluripotency maintenance.
abstract: Pluripotent stem cells provide a powerful tool for both basic and translational research. The establishment and maintenance of germline-competent pluripotent stem cells in vitro, however, have only succeeded in the mouse and rat. From in vivo studies on pluripotency during embryogenesis and in vitro studies on existing pluripotent stem cells, several mechanisms have been uncovered for maintenance of both the naïve and the primed pluripotent states. Current clues strongly indicate that such mechanisms are likely conserved among different species. A better understanding of how these mechanisms work together to control cell fate choice will guide future research in both stem cell biology and regenerative medicine.
authors.affiliation: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Xingliang
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Humberto
authors.initials: H
authors.lastname: Contreras-Trujillo
authors.affiliation: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: qying@med.usc.edu.
authors.forename: Qi-Long
authors.initials: QL
authors.lastname: Ying
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D044968:Regenerative Medicine