title: Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis.
abstract: A significant amount of epidemiological evidences have underlined an emerging link between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement a (BPE). We aimed to assess the connections between LUTS and MetS with its components. Meta-analysis were conducted to determine the mean differences (MD) and confidence intervals of IPSS total score, IPSS-voiding, IPSS-storage and prostate volume (PV) in patients with or without MetS. Ln(odds-ratio) were calculated to estimate the risk of having moderate-to-severe LUTS (IPSS ≥ 8). Nineteen studies were identified as eligible for this systematic review, with a total of 18,476 participants, including 5554 (30.06%) with and 12,922 (69.94%) without MetS. Pooled analysis did not demonstrate significant MD of IPSS, IPSS-voiding and IPSS-storage in men with or without MetS but PV was significantly different (MD = 2.18; p = 0.03). Presence of MetS was not significantly associated with moderate-to-severe LUTS (odds ratio = 1.13; p = 0.53) and only altered serum triglycerides and diabetes were associated with this risk. The association between MetS and LUTS/BPE remain unclear and further observational studies in a population with metabolic disorders should be conducted in order to address it's potential role in determining LUTS/BPE.
authors.affiliation: a Department of Urology and.
authors.forename: Giorgio Ivan
authors.initials: GI
authors.lastname: Russo
authors.affiliation: a Department of Urology and.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Castelli
authors.affiliation: a Department of Urology and.
authors.forename: Daniele
authors.initials: D
authors.lastname: Urzì
authors.affiliation: a Department of Urology and.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Privitera
authors.affiliation: a Department of Urology and.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Fragalà
authors.affiliation: b Department of Medical and Pediatric Sciences, Section of Endocrinology, Andrology, and Internal Medicine , University of Catania , Catania , Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: La Vignera
authors.affiliation: b Department of Medical and Pediatric Sciences, Section of Endocrinology, Andrology, and Internal Medicine , University of Catania , Catania , Italy.
authors.forename: Rosita A
authors.initials: RA
authors.lastname: Condorelli
authors.affiliation: b Department of Medical and Pediatric Sciences, Section of Endocrinology, Andrology, and Internal Medicine , University of Catania , Catania , Italy.
authors.forename: Aldo E
authors.initials: AE
authors.lastname: Calogero
authors.affiliation: a Department of Urology and.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Favilla
authors.affiliation: a Department of Urology and.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Cimino
authors.affiliation: a Department of Urology and.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Morgia
mesh_terms: D000328:Adult; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000209:etiology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D011470:Prostatic Hyperplasia / Q000150:complications*; D012307:Risk Factors
keywords: Age; LUTS; benign prostatic enlargement; insulin resistance; metabolic syndrome; non-alcholic fatty liver disease; prostate; testosterone