title: T-cell lymphoma with von Hippel-Lindau disease: a rare case report and review of literature.
abstract: von Hippel-Lindau disease (VHLD) comprises a series of complicated clinical manifestations. We hereby described a unique case of co-existing T-cell lymphoma (TCL) and confirmed VHLD. The symptoms in this 42-year-old male included fever and pancytopenia. Overall tests and examination made an infectious process unlikely. The results of bone marrow biopsy confirmed the diagnosis. The purposes we described this case were to probe into the relationship between TCL and VHLD, which was not mentioned in previously literature. Combination of clinical, radiological, immunophenotypic, pathological, and genetic data plays an important role in improving the rate of diagnosis, particularly in the challenge for diagnosis of T cell non-Hodgkin lymphoma.
authors.affiliation: International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080, China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Lou
authors.affiliation: International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.affiliation: International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080, China.
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Yan
authors.affiliation: International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.affiliation: International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080, China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Lu
authors.affiliation: International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080, China.
authors.forename: Qu
authors.initials: Q
authors.lastname: Xu
authors.affiliation: International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080, China.
authors.forename: Hai-Qiong
authors.initials: HQ
authors.lastname: Jiang
mesh_terms: D000328:Adult; D001706:Biopsy; D001856:Bone Marrow Examination; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D008297:Male; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D006623:von Hippel-Lindau Disease / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000628:therapy
keywords: T-cell lymphoma; hematological neoplasm; von Hippel-Lindau disease