title: Recurrence of superficial vein thrombosis in patients with varicose veins.
abstract: OBJECTIVE
  To investigate which factors other than history of superficial vein thrombosis (SVT) are associated with recurrent spontaneous SVT episodes in patients with varicose veins (VVs).
  
  
  METHODS
  Patients with a history of spontaneous SVT and VVs were followed up for a mean period of 55 months. Demographics, comorbidities, and thrombophilia screening test were analyzed. Patients were grouped according to the clinical-etiology-anatomy-pathophysiology classification. A multiple logistic regression analysis with the forward likelihood ratio method was undertaken.
  
  
  RESULTS
  Thirteen patients out of 97 had a recurrence SVT episode during the follow-up period. All those patients were identified to have a thrombophilia defect. Protein C and S, antithrombin, and plasminogen deficiencies were more frequently present in patients without recurrence. Gene mutations were present in 38% in the nonrecurrence group and 77% in the recurrence group. After logistic regression analysis, patients with dislipidemia and mutation in prothrombin G20210A (FII) had an increased risk for recurrence by 5.4-fold and 4.6-fold, respectively. No deep vein thrombosis or pulmonary embolism occurred.
  
  
  CONCLUSIONS
  Dislipidemia and gene mutations of F II are associated with SVT recurrence in patients with VVs. A selection of patients may benefit from anticoagulation in the short term and from VVs intervention in the long term.
authors.affiliation: Department of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, University of Thessaly, Larissa, Greece christoskarathanos@yahoo.gr.
authors.forename: Christos
authors.initials: C
authors.lastname: Karathanos
authors.affiliation: Department of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Spanos
authors.affiliation: Department of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
authors.forename: Vassileios
authors.initials: V
authors.lastname: Saleptsis
authors.affiliation: Department of Laboratories of Molecular Biology, Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
authors.forename: Aspasia
authors.initials: A
authors.lastname: Tsezou
authors.affiliation: Department of Genetics and Haematology, Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
authors.forename: Despina
authors.initials: D
authors.lastname: Kyriakou
authors.affiliation: Department of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
authors.forename: Athanasios D
authors.initials: AD
authors.lastname: Giannoukas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D025861:Blood Coagulation Disorders, Inherited / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics; D012008:Recurrence; D012307:Risk Factors; D014648:Varicose Veins / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D020246:Venous Thrombosis / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy
chemical_list: D011516:Prothrombin
keywords: Superficial vein thrombosis; dislipidemia; prothrombin FII mutation; thrombophilia; varicose veins