title: Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis.
abstract: Primary monosymptomatic nocturnal enuresis (PMNE) is a common developmental disorder in children. Previous literature has suggested that PMNE not only is a micturition disorder but also is characterized by cerebral structure abnormalities and dysfunction. However, the biological mechanisms underlying the disease are not thoroughly understood. Graph theoretical analysis has provided a unique tool to reveal the intrinsic attributes of the connectivity patterns of a complex network from a global perspective. Resting-state fMRI was performed in 20 children with PMNE and 20 healthy controls. Brain networks were constructed by computing Pearson's correlations for blood oxygenation level-dependent temporal fluctuations among the 2 groups, followed by graph-based network analyses. The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls. PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus. Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.
authors.affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China ; MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.
authors.forename: Du
authors.initials: D
authors.lastname: Lei
authors.affiliation: Department of Developmental and Behavioral Pediatrics of Shanghai Children's Medical Center, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Children's Environmental Health, Shanghai 200127, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Jilei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Mengxing
authors.initials: M
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Kaihua
authors.initials: K
authors.lastname: Zhang
authors.affiliation: MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.
authors.forename: Fuqin
authors.initials: F
authors.lastname: Chen
authors.affiliation: MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.
authors.forename: Xueling
authors.initials: X
authors.lastname: Suo
authors.affiliation: MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Du
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D002648:Child; D063132:Connectome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology; D053206:Nocturnal Enuresis / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography