title: Synthesis of New Phosphahelicene Scaffolds and Development of Gold(I)-Catalyzed Enantioselective Allenene Cyclizations.
abstract: This paper reports on the development of an efficient synthesis of enantiopure phospha[6]helicenes through a [2+2+2] alkyne cyclotrimerization reaction. The corresponding gold complexes proved to be highly efficient both in terms of catalytic activity and enantioselectivity in [2+2] and [4+2] cycloaddition reactions. Furthermore, in the presence of an external nucleophile, such as water or alcohols, the tandem cyclization/addition reactions take place in high yields and excellent diastereo- and enantioselectivities.
authors.affiliation: Institut de Chimie des Substances Naturelles, ICSN, CNRS UPR 2301, Université Paris-Sud, 1, av. de la Terrasse, 91198 Gif-sur-Yvette (France).
authors.forename: Paul
authors.initials: P
authors.lastname: Aillard
authors.affiliation: Institut de Chimie des Substances Naturelles, ICSN, CNRS UPR 2301, Université Paris-Sud, 1, av. de la Terrasse, 91198 Gif-sur-Yvette (France).
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.affiliation: Institut de Chimie des Substances Naturelles, ICSN, CNRS UPR 2301, Université Paris-Sud, 1, av. de la Terrasse, 91198 Gif-sur-Yvette (France). arnaud.voituriez@cnrs.fr.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Voituriez
authors.affiliation: Institut de Chimie des Substances Naturelles, ICSN, CNRS UPR 2301, Université Paris-Sud, 1, av. de la Terrasse, 91198 Gif-sur-Yvette (France). angela.marinetti@cnrs.fr.
authors.forename: Angela
authors.initials: A
authors.lastname: Marinetti
keywords: allenenes; cyclotrimerization; enantioselectivity; gold catalysis; phosphahelicenes