title: A case of pregnancy complicated with congenital dysprothrombinemia (prothrombin Tokushima).
abstract: We present the course of pregnancy and delivery in a patient with congenital dysprothrombinemia. The patient is a 29-year-old nulliparous woman. She was diagnosed with dysprothrombinemia at 10 years of ag. Her course of pregnancy was uneventful. She delivered after prophylactic lyophilized human blood coagulation factor IX complex 800 U was administered. The plasma prothrombin activity was at 24.0% of normal plasma clotting activity. Her postpartum course was uneventful. After 6 years, her course of pregnancy was the same as before. Prophylactic lyophilized human blood coagulation factor IX complex 800 U was administered. Her plasma prothrombin activity was at 26.7%, and she underwent an induced delivery. Her postpartum course was uneventful. It is beneficial to use prophylactic lyophilized human blood coagulation factor IX complex 800 U in pregnancies that are complicated by dysprothrombinemia. The goal of therapy is to maintain prothrombin levels at above 20%.
authors.affiliation: aGeneral Perinatal Medical Center, Shikoku Medical Center for Children and Adults, Japan bDepartment of Obstetrics and Gynecology, Tokushima University Hospital, Tokushima, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Maeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Kaji
authors.forename: Kana
authors.initials: K
authors.lastname: Kasai
authors.forename: Soichiro
authors.initials: S
authors.lastname: Nakayama
authors.forename: Mikio
authors.initials: M
authors.lastname: Morine
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*; D011516:Prothrombin
chemical_list: C051306:prothrombin Tokushima; D011516:Prothrombin