title: Modeling Viral Infectious Diseases and Development of Antiviral Therapies Using Human Induced Pluripotent Stem Cell-Derived Systems.
abstract: The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate patient-specific models for the investigation of host-pathogen interactions and to develop new antimicrobial and antiviral therapies. Applications of iPSC technology to the study of viral infections in humans have included in vitro modeling of viral infections of neural, liver, and cardiac cells; modeling of human genetic susceptibility to severe viral infectious diseases, such as encephalitis and severe influenza; genetic engineering and genome editing of patient-specific iPSC-derived cells to confer antiviral resistance.
authors.affiliation: Department of Molecular Medicine, University of Padova, via A. Gabelli 63, Padova 35121, Italy. marta.trevisan@unipd.it.
authors.forename: Marta
authors.initials: M
authors.lastname: Trevisan
authors.affiliation: Veneto Institute of Oncology IOV IRCCS, via Gattamelata 64, Padova 35128, Italy. alessandrosinigaglia@yahoo.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sinigaglia
authors.affiliation: Department of Molecular Medicine, University of Padova, via A. Gabelli 63, Padova 35121, Italy. giovanna.desole@studenti.unipd.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Desole
authors.affiliation: Department of Molecular Medicine, University of Padova, via A. Gabelli 63, Padova 35121, Italy. alessandro.berto@studenti.unipd.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Berto
authors.affiliation: Microbiology and Virology Unit, Padova University Hospital, via Giustiniani 2, Padova 35128, Italy. monia.pacenti@sanita.padova.it.
authors.forename: Monia
authors.initials: M
authors.lastname: Pacenti
authors.affiliation: Department of Molecular Medicine, University of Padova, via A. Gabelli 63, Padova 35121, Italy. monia.pacenti@sanita.padova.it.|Microbiology and Virology Unit, Padova University Hospital, via Giustiniani 2, Padova 35128, Italy. monia.pacenti@sanita.padova.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
authors.affiliation: Department of Molecular Medicine, University of Padova, via A. Gabelli 63, Padova 35121, Italy. luisa.barzon@unipd.it.|Microbiology and Virology Unit, Padova University Hospital, via Giustiniani 2, Padova 35128, Italy. luisa.barzon@unipd.it.
authors.forename: Luisa
authors.initials: L
authors.lastname: Barzon
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000187:drug effects / Q000821:virology*; D008954:Models, Biological; D014777:Virus Diseases / Q000188:drug therapy / Q000821:virology*; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000235:genetics
chemical_list: D000998:Antiviral Agents
keywords: CRISPR/Cas9; antiviral resistance; genetic susceptibility; genome editing; hepatitis C virus; human immunodeficiency virus; human induced pluripotent stem cells; patient-specific disease model; personalized therapy; viral infection