title: Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol.
abstract: There are anecdotal reports that some Cannabis preparations may be useful for bladder dysfunctions. Here, we investigated the effect of a number of non- psychotropic phytocannabinoids, namely cannabidiol (CBD), cannabigerol (CBG), cannabidivarin (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabichromene (CBC) on mouse bladder contractility in vitro. CBG, THCV, CBD and CBDV, but not CBC, at concentration ranging from 10(-8) M to 10(-4) M, decreased (with similar potency), the contractions induced by acetylcholine without significantly modifying the contractions induced by electrical stimulation. The rank order of efficacy was CBG=THCV>CBD>CBDV. In depth studies on CBG showed that the effect of this phytocannabinoid on acetylcholine-induced contractions was not affected by CB1 or CB2 receptor antagonists. Additionally, CBG also reduced acetylcholine-induced contractions in the human bladder.
authors.forename: Ester
authors.initials: E
authors.lastname: Pagano
authors.forename: Vittorino
authors.initials: V
authors.lastname: Montanaro
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Girolamo
authors.forename: Antonio
authors.initials: A
authors.lastname: Pistone
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Altieri
authors.forename: Jordan K
authors.initials: JK
authors.lastname: Zjawiony
authors.forename: Angelo A
authors.initials: AA
authors.lastname: Izzo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Capasso
mesh_terms: D000818:Animals; D002186:Cannabinoids / Q000737:chemistry / Q000494:pharmacology*; D002188:Cannabis / Q000737:chemistry*; D006801:Humans; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D002186:Cannabinoids; D010936:Plant Extracts; C037036:cannabigerol