title: Altered Spontaneous Brain Activity in Schizophrenia: A Meta-Analysis and a Large-Sample Study.
abstract: Altered spontaneous brain activity as measured by ALFF, fALFF, and ReHo has been reported in schizophrenia, but no consensus has been reached on alternations of these indexes in the disorder. We aimed to clarify the regional alterations in ALFF, fALFF, and ReHo in schizophrenia using a meta-analysis and a large-sample validation. A meta-analysis of activation likelihood estimation was conducted based on the abnormal foci of ten studies. A large sample of 86 schizophrenia patients and 89 healthy controls was compared to verify the results of the meta-analysis. Meta-analysis demonstrated that the alternations in ALFF and ReHo had similar distribution in schizophrenia patients. The foci with decreased ALFF/fALFF and ReHo in schizophrenia were mainly located in the somatosensory cortex, posterior parietal cortex, and occipital cortex; however, foci with increased ALFF/fALFF and ReHo were mainly located in the bilateral striatum, medial temporal cortex, and medial prefrontal cortex. The large-sample study showed consistent findings with the meta-analysis. These findings may expound the pathophysiological hypothesis and guide future research.
authors.affiliation: Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Tianjin Anning Hospital, Tianjin 300300, China.
authors.forename: Chuanjun
authors.initials: C
authors.lastname: Zhuo
authors.affiliation: Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Qin
authors.affiliation: Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
mesh_terms: D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000503:physiopathology*