title: Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis.
abstract: Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.
authors.affiliation: Department of Chemistry, KTH Royal Institute of Technology Teknikringen 30, S-10044 Stockholm, Sweden E-mail: ramstrom@kth.se.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, KTH Royal Institute of Technology Teknikringen 30, S-10044 Stockholm, Sweden E-mail: ramstrom@kth.se.
authors.forename: Pornrapee
authors.initials: P
authors.lastname: Vongvilai
authors.affiliation: Department of Chemistry, KTH Royal Institute of Technology Teknikringen 30, S-10044 Stockholm, Sweden E-mail: ramstrom@kth.se.
authors.forename: Morakot
authors.initials: M
authors.lastname: Sakulsombat
authors.affiliation: Department of Chemistry, KTH Royal Institute of Technology Teknikringen 30, S-10044 Stockholm, Sweden E-mail: ramstrom@kth.se.
authors.forename: Andreas
authors.initials: A
authors.lastname: Fischer
authors.affiliation: Department of Chemistry, KTH Royal Institute of Technology Teknikringen 30, S-10044 Stockholm, Sweden E-mail: ramstrom@kth.se.
authors.forename: Olof
authors.initials: O
authors.lastname: Ramström
keywords: adaptive features; biotransformations; chiral resolution; domino reactions; dynamic chemistry; enzymes; lipase; stereochemistry