title: Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors.
abstract: An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
authors.forename: Cassandra E
authors.initials: CE
authors.lastname: Callmann
authors.affiliation: Department of Radiology, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Barback
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Thompson
authors.affiliation: Department of Radiology, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hall
authors.affiliation: Department of Radiology, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Mattrey
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Gianneschi
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D015331:Cohort Studies; D004337:Drug Carriers / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000201:enzymology; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D020714:Maximum Tolerated Dose; D008819:Mice, Nude; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry; D009368:Neoplasm Transplantation; D061848:Optical Imaging; D017239:Paclitaxel / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry; D047368:Tumor Burden
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D020782:Matrix Metalloproteinases; D017239:Paclitaxel
keywords: drug delivery; enzyme-responsive; nanomaterials; self-assembly; stimuli-responsive