title: Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z.
abstract: Acquisition of blaNDM-1 in bacterial species, such as Proteus mirabilis that is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate of P. mirabilis (PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant on chromosome.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Shangshang
authors.initials: S
authors.lastname: Qin
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Qi
authors.affiliation: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
authors.forename: Qijing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhao
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Tian
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Xu
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Zhou
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China xjfeng62688@163.com liuhm@zzu.edu.cn.
authors.forename: Xianju
authors.initials: X
authors.lastname: Feng
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China xjfeng62688@163.com liuhm@zzu.edu.cn.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology; D016680:Genome, Bacterial / Q000235:genetics; D044404:Genomic Islands / Q000235:genetics*; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D011513:Proteus mirabilis / Q000235:genetics*; D012475:Salmonella / Q000235:genetics; D013752:Tetracycline / Q000494:pharmacology; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D013752:Tetracycline; D008911:Minocycline; D003091:Colistin