title: Possible prevention of dialysis-requiring congestive heart failure by angiotensin-II receptor blockers in non-dialysis Japanese patients with Stage 5 chronic kidney disease.
abstract: BACKGROUND
  Preventive medications for dialysis-requiring congestive heart failure (CHF) in non-dialysis Japanese patients with Stage 5 chronic kidney disease (CKD) are unknown. Our aim was to explore which CKD medication was associated with a reduced prevalence of dialysis-requiring CHF in non-dialysis Japanese patients with Stage 5 CKD.
  
  
  METHODS
  The present multicenter, retrospective, cross-sectional study examined the association between CKD medications and the prevalence of dialysis-requiring CHF in non-dialysis Japanese patients with Stage 5 CKD.
  
  
  RESULTS
  There were 1536 Japanese Stage 5 CKD patients who satisfied our inclusion criteria. We had 309 (20.1%) patients whom had developed dialysis-requiring CHF and 940 patients (60.8%) whom had been using angiotensin-II receptor blockers (ARBs) before initiating dialysis. In our multivariate analysis, only ARB use was significantly associated with a lower risk of CHF (Odds ratio (OR): 0.680, 95% confidence interval (CI): 0.516-0.897; p = 0.0064), of the CKD treatments examined in this study.
  
  
  CONCLUSIONS
  We found that ARB use during the pre-dialysis period is associated with a lower prevalence of CHF in the non-dialysis Japanese patients with Stage 5 CKD, suggesting a possible prevention of dialysis-requiring CHF by ARBs, in non-dialysis Japanese patients with Stage 5 CKD.
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Katsushika medical center, Tokyo, Japan aoto-jinnai@jikei.ac.jp.
authors.forename: Masato
authors.initials: M
authors.lastname: Ikeda
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Katsushika medical center, Tokyo, Japan.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Nakao
authors.affiliation: Department of Nephrology, Asikaga Red Cross Hospital, Gunma, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Hirano
authors.affiliation: Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Yokoyama
authors.affiliation: Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoo
authors.affiliation: Division of Nephrology, Toho University, Ohashi Medical Center, Tokyo, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Joki
authors.affiliation: Department of Nephrology, Musashino Red Cross Hospital, Tokyo, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Ando
authors.affiliation: Dialysis Center, Kawakita General Hospital, Tokyo, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Shinoda
authors.affiliation: Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan.
authors.forename: Daijo
authors.initials: D
authors.lastname: Inaguma
authors.affiliation: Department of Clinical Engineering, Tokyo Yamate Medical Center, Tokyo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamaka
authors.affiliation: Department of Nephrology, Division of Internal Medicine, Saint Luke's International Hospital, Tokyo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Komatsu
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Koiwa
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Sakaguchi
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Negi
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shigematsu
mesh_terms: D000368:Aged; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use*; D044466:Asian People; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D015995:Prevalence; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D057911:Angiotensin Receptor Antagonists
keywords: Angiotensin-II receptor blockers; Japan; Stage 5; angiotensin-converting enzyme inhibitors; chronic kidney disease; congestive heart failure; dialysis; dialysis avoidance; preventive medication; renal replacement therapy