title: Role of aggressive surgical cytoreduction in advanced ovarian cancer.
abstract: Ovarian cancer is the eighth most frequent cancer in women and is the most lethal gynecologic malignancy worldwide. The majority of ovarian cancer patients are newly diagnosed presenting with advanced-stage disease. Primary cytoreductive surgery and adjuvant taxane- and platinum-based combination chemotherapy are the standard treatment for advanced ovarian cancer. A number of studies have consistently shown that successful cytoreductive surgery and the resultant minimal residual disease are significantly associated with survival in patients with this disease. Much has been written and even more debated regarding the competing perspectives of biology of ovarian cancer versus the value of aggressive surgical resection. This review will focus on the current evidences and outcomes supporting the positive impact of aggressive surgical effort on survival in the primary management of ovarian cancer.
authors.affiliation: Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea. drchang@ajou.ac.kr.
authors.forename: Suk Joon
authors.initials: SJ
authors.lastname: Chang
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Irvine School of Medicine, Orange, CA, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Bristow
authors.affiliation: Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Dennis S
authors.initials: DS
authors.lastname: Chi
authors.affiliation: Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Cliby
mesh_terms: D065426:Cytoreduction Surgical Procedures / Q000379:methods*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D018365:Neoplasm, Residual / Q000601:surgery; D015588:Observer Variation; D010051:Ovarian Neoplasms / Q000601:surgery*; D010818:Practice Patterns, Physicians'; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies
keywords: Cytoreduction Surgical Procedures; Neoplasm, Residual; Ovarian Neoplasms