title: Insulin resistance is not independently associated with chronic kidney disease in Chinese population: A population-based cross-sectional study.
abstract: BACKGROUND
  Metabolic syndrome (MS) may modify the association of insulin resistance (IR) with chronic kidney disease (CKD), but the relevant studies were not enough. We evaluated whether IR is independently associated with CKD in Chinese population.
  
  
  METHODS
  The data were from 2007-2008 China National Diabetes and Metabolic Disorders Study. CKD was defined as an estimated glomerular filtration rate <60ml/min/1.73m(2). IR was evaluated by using the homeostatic model assessment (HOMA-IR).
  
  
  RESULTS
  A total of 11,143 individuals were included. Participants in the higher quartiles of HOMA-IR tended to have higher prevalence of CKD in general population (P<0.001). However, there was no significant difference among the quartiles of HOMA-IR in population without MS (P=0.288). In general population, the adjusted odds ratio of CKD was 1.183 (95% CI: 0.838-1.670), 1.543 (95% CI: 1.103-2.158), and 1.549 (95% CI: 1.079-2.223) in the second, third and fourth quartile of HOMA-IR relative to the lowest quartile, while the odds ratios in population without MS showed no significance in all higher quartiles.
  
  
  CONCLUSIONS
  IR was not an independently significant predictor of CKD in Chinese population, and MS may contribute greatly to the association between IR and CKD.
authors.affiliation: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Jing
authors.affiliation: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Shaoyong
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ming
authors.affiliation: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Han
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address: jqiuhe@fmmu.edu.cn.
authors.forename: Qiuhe
authors.initials: Q
authors.lastname: Ji
mesh_terms: D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D015999:Multivariate Analysis; D051436:Renal Insufficiency, Chronic / Q000150:complications*
keywords: Chinese adults; Chronic kidney disease; Epidemiology and outcomes; Insulin resistance; Metabolic syndrome