title: [Expression of Girdin in brain tissues of Alzheimer's disease].
abstract: OBJECTIVE
  To investigate the expression of Girdin and its significance in Alzheimer's disease (AD).
  
  
  METHODS
  Fifty-nine autopsy cases from Department of Pathology, Beijing Hospital from January 1988 to December 2013, including 35 AD cases and 24 non-AD cases as control. Girdin and amyloid β-protein (Aβ) expression was evaluated immunohistochemically by EnVision method. The correlation between Girdin and Aβ was analyzed.
  
  
  RESULTS
  Girdin expression was localized in the nucleus and/or cytoplasm. The expression rates of Girdin were 20.0% (7/35) in the AD group and 83.3% (20/24) in the non-AD group, respectively. The difference was significant (Yates's correction for continuity χ(2)=20.527, P<0.05). Girdin expression and Aβ deposition also correlated significantly (P<0.05).
  
  
  CONCLUSIONS
  Girdin shows reduced expression in AD, and is correlated positively with Aβ deposition. This suggests that Girdin may play an important role in the occurrence and development of AD.
authors.affiliation: Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors.forename: Longteng
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors.forename: Di
authors.initials: D
authors.lastname: Cui
authors.affiliation: Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China; E-mail:liudongge@sohu.com.
authors.forename: Dongge
authors.initials: D
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001344:Autopsy; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; C502451:CCDC88A protein, human; D008840:Microfilament Proteins; D033921:Vesicular Transport Proteins