title: Promotive Effects of Dcr3 Gene on the Occurrence and Progression of Gastric Cancer and its Mechanism.
abstract: OBJECTIVE
  To observe the effects of DcR3 gene on the occurrence and progression of gastric cancer and explore its mechanism.
  
  
  METHODS
  DcR3 mRNA expressions in both gastric normal tissue and gastric cancer tissue were detected with RT-PCR. Apoptosis index (AI) was determined with terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL).
  
  
  RESULTS
  Positive rate of DcR3 mRNA expression was significantly higher in gastric cancer tissue than in gastric normal tissue (P < 0.01). The level of DcR3 mRNA expression was related to differentiation, lymphatic metastasis and TNM staging (P < 0.05). The level of DcR3 mRNA expression was inversely correlated with AI (P < 0.01).
  
  
  CONCLUSIONS
  DcR3 plays an important role in the occurrence and progression of gastric cancer possibly through inhibiting gastric cancer cell apoptosis.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Zheng
authors.forename: Lan-Ying
authors.initials: LY
authors.lastname: Miao
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis; D016022:Case-Control Studies; D002454:Cell Differentiation; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012333:RNA, Messenger / Q000032:analysis; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D012333:RNA, Messenger; D053323:Receptors, Tumor Necrosis Factor, Member 6b; C505911:TNFRSF6B protein, human