title: A new phase of drug discovery? The rise of PK/PD means extremely challenging work at the coalface.
authors.affiliation: 4 The Maltings, Walmer, Kent CT147AR, UK.
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Smith
mesh_terms: D002851:Chromatography, High Pressure Liquid; D055808:Drug Discovery; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D011433:Propranolol / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D004364:Pharmaceutical Preparations; D011433:Propranolol
keywords: DMPK; LC–MS; PK/PD; binding; discovery; intracellular; occupancy; propranolol