title: What happens at or after transcription: Insights into circRNA biogenesis and function.
abstract: Circular RNAs (circRNAs) are a large family of noncoding RNAs (ncRNAs) found in metazoans. Systematic studies of circRNAs have just begun. Here, we discuss circRNA biogenesis and functions with a focus on studies indicating great diversification of circRNAs. We highlight the recent identification of a special subtype of circRNAs, called EIciRNAs, and their role in transcriptional regulation. New insights on RNA-RNA interaction and other features associated with circRNA biology are also discussed.
authors.affiliation: a School of Life Sciences & CAS Key Laboratory of Brain Function and Disease; University of Science and Technology of China ; Hefei , Anhui Province , China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Huang
authors.affiliation: a School of Life Sciences & CAS Key Laboratory of Brain Function and Disease; University of Science and Technology of China ; Hefei , Anhui Province , China.
authors.forename: Ge
authors.initials: G
authors.lastname: Shan
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D000079962:RNA, Circular; D022661:RNA, Untranslated / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D000079962:RNA, Circular; D022661:RNA, Untranslated; D017412:Ribonucleoprotein, U1 Small Nuclear; D012313:RNA
keywords: biogenesis; circular RNA; exon-intron circular RNA; microRNA sponge; transcriptional regulation