title: FoxO1: mute for a tuned metabolism?
abstract: The transcription factor forkhead box O1 (FoxO1) plays pleiotropic roles in insulin-mediated glucose and lipid metabolism. In the liver, glucose production is finely controlled by insulin signaling that dampens FoxO1. Two recent studies show that silencing of FoxO1 is also essential for extra-hepatic insulin signaling to maintain glucose homeostasis.
authors.affiliation: Department of Human Nutrition, Foods and Exercise, Fralin Translational Obesity Research Center, College of Agriculture and Life Science, Virginia Tech, Blacksburg, VA, USA. Electronic address: zcheng@vt.edu.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D005943:Gluconeogenesis / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011972:Receptor, Insulin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051858:Forkhead Transcription Factors; D007328:Insulin; D011972:Receptor, Insulin; D005947:Glucose
keywords: FoxO1; glucose; insulin resistance; insulin signaling; lipid; metabolic homeostasis