title: Expression of the estrogen receptor α, progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues.
abstract: The present study aimed to determine the protein expression, in addition to the clinical value of the expression, of estrogen receptor α (ERα), progesterone receptor (PR) and epidermal growth factor receptor (EGFR) in papillary thyroid carcinoma (PTC). The expression of ERα, PR and EGFR was examined immunohistochemically on paraffin-embedded thyroid tissues obtained from 64 patients with PTC and 14 patients with nodular thyroid goiter (NTG). The expression level of ERα, PR and EGFR was found to be significantly elevated in the PTC tissues compared with the NTG tissues. In addition, the expression of ERα was found to be correlated with the size of PTC tumors. However, there was no significant difference between the expression levels of ERα, PR and EGFR in males and females with PTC. Thus, immunohistochemical evaluation of ERα, PR and EGFR expression in patients with PTC may aid in the prediction of the prognosis of patients with PTC.
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Qi
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China.
authors.forename: Pengxin
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Guan
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
authors.forename: Lifen
authors.initials: L
authors.lastname: Wang
keywords: epidermal growth factor receptor; estrogen receptor α; papillary thyroid carcinoma; progesterone receptor