title: Theoretical analysis of degradation mechanisms in the formation of morphogen gradients.
abstract: Fundamental biological processes of development of tissues and organs in multicellular organisms are governed by various signaling molecules, which are called morphogens. It is known that spatial and temporal variations in the concentration profiles of signaling molecules, which are frequently referred as morphogen gradients, lead to a cell differentiation via activating specific genes in a concentration-dependent manner. It is widely accepted that the establishment of the morphogen gradients involves multiple biochemical reactions and diffusion processes. One of the critical elements in the formation of morphogen gradients is a degradation of signaling molecules. We develop a new theoretical approach that provides a comprehensive description of the degradation mechanisms. It is based on the idea that the degradation works as an effective potential that drives the signaling molecules away from the source region. Utilizing the method of first-passage processes, the dynamics of the formation of morphogen gradients for various degradation mechanisms is explicitly evaluated. It is found that linear degradation processes lead to a dynamic behavior specified by times to form the morphogen gradients that depend linearly on the distance from the source. This is because the effective potential due to the degradation is quite strong. At the same time, nonlinear degradation mechanisms yield a quadratic scaling in the morphogen gradients formation times since the effective potentials are much weaker. Physical-chemical explanations of these phenomena are presented.
authors.affiliation: Department of Chemistry and Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005-1892, USA.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Bozorgui
authors.affiliation: Department of Chemistry and Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005-1892, USA.
authors.forename: Hamid
authors.initials: H
authors.lastname: Teimouri
authors.affiliation: Department of Chemistry and Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005-1892, USA.
authors.forename: Anatoly B
authors.initials: AB
authors.lastname: Kolomeisky
mesh_terms: D016014:Linear Models; D008954:Models, Biological; D008958:Models, Molecular; D017711:Nonlinear Dynamics; D059748:Proteolysis; D015398:Signal Transduction / Q000502:physiology*