title: Global cognitive scores do not predict outcome after subthalamic nucleus deep brain stimulation.
abstract: BACKGROUND
  Presence of dementia is a contraindication for DBS treatment of Parkinson's disease. Recent evidence suggests that borderline cognitive function, as measured with a common screening measure, the Mattis Dementia Rating Scale, has a negative impact on quality of life (QoL) after DBS of the STN.
  
  
  METHODS
  We attempted to replicate and extend this finding in a larger group of patients with a wider range of preoperative global cognitive performance.
  
  
  RESULTS
  Our data indicate that performance on the screening measure is not associated with QoL or medical outcomes, even with scores well below the cutoff for identifying dementia.
  
  
  CONCLUSIONS
  This cognitive screening measure lacks sufficient sensitivity to warrant its use in predicting which patients will show QoL benefit from DBS.
authors.affiliation: Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Darlene
authors.initials: D
authors.lastname: Floden
authors.affiliation: Epilepsy Center, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Robyn M
authors.initials: RM
authors.lastname: Busch
authors.affiliation: Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Cooper
authors.affiliation: Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Kubu
authors.affiliation: Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Andre G
authors.initials: AG
authors.lastname: Machado
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D003071:Cognition; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D006801:Humans; D007206:Individuality; D008297:Male; D008875:Middle Aged; D009068:Movement; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D011788:Quality of Life / Q000523:psychology; D012189:Retrospective Studies; D020531:Subthalamic Nucleus / Q000502:physiology*; D016896:Treatment Outcome
keywords: Parkinson's disease; cognition; deep brain stimulation; outcome research; quality of life