title: Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy.
abstract: The osseointegration capacity of bone-anchoring implants can be improved by the use of drugs that are administrated by an inbuilt drug delivery system. However, to attain superior control of drug delivery and to have the ability to administer drugs of varying size, including proteins, further material development of drug carriers is needed. Mesoporous materials have shown great potential in drug delivery applications to provide and maintain a drug concentration within the therapeutic window for the desired period of time. Moreover, drug delivery from coatings consisting of mesoporous titania has shown to be promising to improve healing of bone-anchoring implants. Here we report on how the delivery of an osteoporosis drug, alendronate, can be controlled by altering pore size and surface energy of mesoporous titania thin films. The pore size was varied from 3.4 nm to 7.2 nm by the use of different structure-directing templates and addition of a swelling agent. The surface energy was also altered by grafting dimethylsilane to the pore walls. The drug uptake and release profiles were monitored in situ using quartz crystal microbalance with dissipation (QCM-D) and it was shown that both pore size and surface energy had a profound effect on both the adsorption and release kinetics of alendronate. The QCM-D data provided evidence that the drug delivery from mesoporous titania films is controlled by a binding-diffusion mechanism. The yielded knowledge of release kinetics is crucial in order to improve the in vivo tissue response associated to therapeutic treatments.
authors.affiliation: Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Karlsson
authors.affiliation: Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
authors.forename: Saba
authors.initials: S
authors.lastname: Atefyekta
authors.affiliation: Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Andersson
mesh_terms: D019386:Alendronate / Q000737:chemistry / Q000493:pharmacokinetics; D050071:Bone Density Conservation Agents / Q000737:chemistry / Q000493:pharmacokinetics; D018786:Bone Substitutes; D016503:Drug Delivery Systems; D007700:Kinetics; D058608:Nanopores; D010316:Particle Size; D016062:Porosity; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D050071:Bone Density Conservation Agents; D018786:Bone Substitutes; C009495:titanium dioxide; D014025:Titanium; D019386:Alendronate
keywords: QCM-D; alendronate; controlled drug delivery; mesoporous titania; release kinetics