title: A new labdane diterpene from the rhizomes of Alpinia officinarum.
abstract: A new labdane diterpene, (Z)-12,14-labdadien-15(16)-olide-17-oic acid (1), and a new natural cadinane sesquiterpene, 4-isopropyl-6-methyl-1-naphthalenemethanol (2), were isolated from the ethanolic extract of the rhizomes of Alpinia officinarum, together with three other products, galangin (3), kaempferol (4) and quercetin (5). Their structures were elucidated by using extensive spectroscopic methods. Compounds 1 and 2 showed no remarkable cytotoxic activity against HeLa and HepG2 cancer cell lines with IC50>50 μg mL(- 1).
authors.affiliation: a Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Yingfeng East Road, Huaihua , Hecheng District, Hunan 418008 , P.R. China.
authors.forename: Qiong-Yu
authors.initials: QY
authors.lastname: Zou
authors.affiliation: b Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine , Peking Union Medical College, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences , Beijing 100193 , P.R. China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.affiliation: a Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Yingfeng East Road, Huaihua , Hecheng District, Hunan 418008 , P.R. China.
authors.forename: Yu-Lian
authors.initials: YL
authors.lastname: Tang
authors.affiliation: a Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Yingfeng East Road, Huaihua , Hecheng District, Hunan 418008 , P.R. China.
authors.forename: Di-Zhao
authors.initials: DZ
authors.lastname: Chen
mesh_terms: D032429:Alpinia / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005419:Flavonoids / Q000302:isolation & purification; D006367:HeLa Cells / Q000187:drug effects; D056945:Hep G2 Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D044949:Kaempferols / Q000302:isolation & purification; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D011794:Quercetin / Q000302:isolation & purification; D027343:Rhizome / Q000737:chemistry*
chemical_list: C000609405:12,14-labdadien-15(16)-olide-17-oic acid; C000609406:4-isopropyl-6-methyl-1-naphthalenemethanol; D004224:Diterpenes; D005419:Flavonoids; D044949:Kaempferols; D009281:Naphthalenes; D010936:Plant Extracts; C433017:labdane; C037032:galangin; C006552:kaempferol; D011794:Quercetin
keywords: Alpinia officinarum; cadinane sesquiterpene; labdane diterpene