title: A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory.
abstract: David T. Yue was a renowned biophysicist who dedicated his life to the study of Ca(2+) signaling in cells. In the wake of his passing, we are left not only with a feeling of great loss, but with a tremendous and impactful body of work contributed by a remarkable man. David's research spanned the spectrum from atomic structure to organ systems, with a quantitative rigor aimed at understanding the fundamental mechanisms underlying biological function. Along the way he developed new tools and approaches, enabling not only his own research but that of his contemporaries and those who will come after him. While we cannot hope to replicate the eloquence and style we are accustomed to in David's writing, we nonetheless undertake a review of David's chosen field of study with a focus on many of his contributions to the calcium channel field.
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Ivy E
authors.initials: IE
authors.lastname: Dick
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Worawan B
authors.initials: WB
authors.lastname: Limpitikul
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Niu
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Banerjee
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Issa
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Manu
authors.initials: M
authors.lastname: Ben-Johny
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.|b Kwantlen Polytechnic University ; Surrey , BC Canada.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Adams
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Po Wei
authors.initials: PW
authors.lastname: Kang
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Shin Rong
authors.initials: SR
authors.lastname: Lee
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Sang
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Wanjun
authors.initials: W
authors.lastname: Yang
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Babich
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Manning
authors.initials: M
authors.lastname: Zhang
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Hojjat
authors.initials: H
authors.lastname: Bazazzi
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Nancy C
authors.initials: NC
authors.lastname: Yue
authors.affiliation: a Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.|c Division of Cardiology; Department of Medicine ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Gordon F
authors.initials: GF
authors.lastname: Tomaselli
mesh_terms: D000818:Animals; D001703:Biophysics / Q000266:history*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D049673:History, 20th Century; D049674:History, 21st Century; D014481:United States
chemical_list: D015220:Calcium Channels
keywords: biophysics; calcium channel; calmodulin; protein kinase A; single channels; sodium channel