title: Mesenchymal Stem Cells as a Biological Drug for Heart Disease: Where Are We With Cardiac Cell-Based Therapy?
abstract: Cell-based treatment represents a new generation in the evolution of biological therapeutics. A prototypic cell-based therapy, the mesenchymal stem cell, has successfully entered phase III pivotal trials for heart failure, signifying adequate enabling safety and efficacy data from phase I and II trials. Successful phase III trials can lead to approval of a new biological therapy for regenerative medicine.
authors.affiliation: From the Interdisciplinary Stem Cell Institute (C.S., J.M.H.), Department of Medicine, Division of Cardiology (J.M.H.), and Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, FL (J.M.H.).
authors.forename: Cristina
authors.initials: C
authors.lastname: Sanina
authors.affiliation: From the Interdisciplinary Stem Cell Institute (C.S., J.M.H.), Department of Medicine, Division of Cardiology (J.M.H.), and Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, FL (J.M.H.). jhare@med.miami.edu.
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Hare
mesh_terms: D064591:Allografts; D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D023381:Endpoint Determination; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods / Q000639:trends*; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000628:therapy*; D017202:Myocardial Ischemia / Q000628:therapy; D010865:Pilot Projects; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
keywords: cell- and tissue-based therapy; chronic heart failure; clinical trial; heart disease; mesenchymal stem cells