title: Inverse association between diabetes and aortic dilatation in patients with advanced coronary artery disease.
abstract: BACKGROUND
  A negative association between diabetes and abdominal aortic aneurysm has recently been reported. The purpose of this study was to assess the relationship between diabetes and aortic diameter, including non-aneurysmal aortic diameter, in patients with advanced coronary artery disease.
  
  
  METHODS
  We identified 351 consecutive patients who had undergone coronary artery bypass graft surgery. The patients were divided into two groups: those with diabetes mellitus (DM) (DM+ group; n = 180), and those without DM (DM- group; n = 171). Infrarenal and ascending aortic diameters were measured by preoperative computed tomography and corrected for body surface area.
  
  
  RESULTS
  Infrarenal and ascending aortic diameters were significantly shorter in the DM+ group than in the DM- group (21.3 ± 5.0 mm vs. 24.7 ± 9.8 mm, p < 0.001 and 36.0 ± 4.4 mm vs. 37.8 ± 5.5 mm, p = 0.001, respectively). The rates of infrarenal aortic diameter ≥30 mm and ascending aortic diameter ≥40 mm were significantly lower in the DM+ group than in the DM- group (3.5% vs. 13.3%, p = 0.003 and 14.2% vs. 24.1%, p = 0.025, respectively). Multivariate models demonstrated diabetes to be an independent predictor of both infrarenal and ascending aortic diameters even after correction for body surface area.
  
  
  CONCLUSIONS
  Our findings indicated an inverse association between diabetes and aortic dilatation of both the infrarenal and ascending aorta in patients with advanced coronary artery disease.
authors.affiliation: The Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: akihito17491194@gmail.com.
authors.forename: Akihito
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: The Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishii
authors.affiliation: The Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Oshima
authors.affiliation: The Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Narita
authors.affiliation: The Department of Vascular Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Kodama
authors.affiliation: The Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: The Department of Vascular Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Komori
authors.affiliation: The Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Usui
authors.affiliation: The Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D000368:Aged; D001011:Aorta / Q000473:pathology*; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology*; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology; D001027:Aortography; D015897:Comorbidity; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D012306:Risk; D012907:Smoking / Q000453:epidemiology; D014057:Tomography, X-Ray Computed
keywords: Advanced coronary artery disease; Aortic dilatation; Diabetes