title: Acute exposure to silica nanoparticles aggravate airway inflammation: different effects according to surface characteristics.
abstract: Silica nanoparticles (SNPs) are widely used in many scientific and industrial fields despite the lack of proper evaluation of their potential toxicity. This study examined the effects of acute exposure to SNPs, either alone or in conjunction with ovalbumin (OVA), by studying the respiratory systems in exposed mouse models. Three types of SNPs were used: spherical SNPs (S-SNPs), mesoporous SNPs (M-SNPs), and PEGylated SNPs (P-SNPs). In the acute SNP exposure model performed, 6-week-old BALB/c female mice were intranasally inoculated with SNPs for 3 consecutive days. In the OVA/SNPs asthma model, the mice were sensitized two times via the peritoneal route with OVA. Additionally, the mice endured OVA with or without SNP challenges intranasally. Acute SNP exposure induced significant airway inflammation and airway hyper-responsiveness, particularly in the S-SNP group. In OVA/SNPs asthma models, OVA with SNP-treated group showed significant airway inflammation, more than those treated with only OVA and without SNPs. In these models, the P-SNP group induced lower levels of inflammation on airways than both the S-SNP or M-SNP groups. Interleukin (IL)-5, IL-13, IL-1β and interferon-γ levels correlated with airway inflammation in the tested models, without statistical significance. In the mouse models studied, increased airway inflammation was associated with acute SNPs exposure, whether exposed solely to SNPs or SNPs in conjunction with OVA. P-SNPs appear to be relatively safer for clinical use than S-SNPs and M-SNPs, as determined by lower observed toxicity and airway system inflammation.
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Park
authors.affiliation: 1] Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea [2] Department of Life Science, Research Institute for Natural Sciences, Hanyang Biomedical Research Institute, Hanyang University, Seoul, Korea.
authors.forename: Jung-Ho
authors.initials: JH
authors.lastname: Sohn
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Yoon-Ju
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Yoon Hee
authors.initials: YH
authors.lastname: Park
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Heejae
authors.initials: H
authors.lastname: Han
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Korea.
authors.forename: Kangtaek
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Korea.
authors.forename: Kiju
authors.initials: K
authors.lastname: Um
authors.affiliation: Department of Microbiology, Brain Korea 21 Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: In-Hong
authors.initials: IH
authors.lastname: Choi
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Park
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000818:Animals; D001249:Asthma / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D007249:Inflammation / Q000139:chemically induced* / Q000473:pathology; D007371:Interferon-gamma / Q000032:analysis; D007378:Interleukins / Q000032:analysis; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000009:adverse effects* / Q000737:chemistry; D010047:Ovalbumin / Q000009:adverse effects; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000737:chemistry; D012822:Silicon Dioxide / Q000009:adverse effects* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D007378:Interleukins; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D007371:Interferon-gamma; D010047:Ovalbumin