title: Alpha Emitter Radium 223 in High-Risk Osteosarcoma: First Clinical Evidence of Response and Blood-Brain Barrier Penetration.
authors.affiliation: Divisions of Cancer Medicine and Pediatrics, Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Vivek
authors.initials: V
authors.lastname: Subbiah
authors.affiliation: Department of Pediatrics, Levine Children's Hospital, Charlotte, North Carolina.
authors.forename: Pete
authors.initials: P
authors.lastname: Anderson
authors.affiliation: Division of Diagnostic Imaging, Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Eric
authors.initials: E
authors.lastname: Rohren
mesh_terms: D000328:Adult; D001812:Blood-Brain Barrier / Q000000981:diagnostic imaging / Q000378:metabolism*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary*; D017321:Clinical Trials, Phase I as Topic; D005266:Femoral Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary*; D010539:Permeability; D049268:Positron-Emission Tomography; D011868:Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011883:Radium / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013997:Time Factors; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; C581106:radium Ra 223 dichloride; D011883:Radium