title: Clinician response time for positive blood culture results in a pediatric ICU.
abstract: BACKGROUND
  Positive blood cultures guide clinicians to prescribe specific therapy based on in vitro susceptibility. Delays in appropriate antibiotic therapy increase morbidity associated with positive blood culture.
  
  
  OBJECTIVE
  Time from clinician notification of positive blood culture to administration of targeted antimicrobial therapy should follow Surviving Sepsis guidelines.
  
  
  METHODS
  Study setting was a 44 bed pediatric ICU. Data were extracted from the pharmacy database and the medical records of pediatric ICU patients with positive blood culture. Source, time blood culture was obtained, time of clinician notification of positive result, and administration time of first dose of new antimicrobial was captured.
  
  
  RESULTS
  174 positive blood cultures from 111 PICU patients were examined. Antimicrobials were changed after the positive culture in 51 (49%) patients. The new antibiotic was administered in an average of 6 h 35 min from clinician notification.
  
  
  CONCLUSIONS
  We demonstrated a delay from clinician notification of positive culture to new antibiotic administration.
authors.affiliation: Primary Children's Hospital, 100 North Mario Capecchi Drive, Salt Lake City, UT 84113, USA. Electronic address: Maryjo.grant@imail.org.
authors.forename: Mary Jo C
authors.initials: MJ
authors.lastname: Grant
authors.affiliation: Primary Children's Hospital, 100 North Mario Capecchi Drive, Salt Lake City, UT 84113, USA.
authors.forename: Jared
authors.initials: J
authors.lastname: Olson
authors.affiliation: Primary Children's Hospital, 100 North Mario Capecchi Drive, Salt Lake City, UT 84113, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Gerber
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000175:diagnosis* / Q000188:drug therapy*; D002648:Child; D019983:Guideline Adherence; D006801:Humans; D007362:Intensive Care Units / Q000592:standards*; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic stewardship; Antimicrobial; Bacteremia; Blood culture; Pediatric intensive care unit