title: [An update on the conceptual and classification issues of anxiety, its neuroanatomy and problems of anxiolytic drug discovery].
abstract: Anxiety disorders are highly prevalent psychiatric diseases. In this short review we provide an overview of concepts of fear, anxiety and anxiety disorders. In addition, based on the recent literature, neuroanatomical structures involved in anxiety and functional/structural changes of these structures in anxiety disorders are also discussed. Furthemore, the pitfalls of anxiolytic drug discovery is also concerned in the paper.
authors.affiliation: a Department of Clinical and Theoretical Mental Health, Semmelweis University, Faculty of Medicine, Budapest, Hungary. faludi.gabor@med.semmelweis-univ.hu.
authors.forename: Gábor
authors.initials: G
authors.lastname: Faludi
authors.forename: Xénia
authors.initials: X
authors.lastname: Gonda
authors.forename: Péter
authors.initials: P
authors.lastname: Döme
mesh_terms: D000679:Amygdala / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use; D001007:Anxiety / Q000145:classification / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D001008:Anxiety Disorders / Q000145:classification / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D055808:Drug Discovery; D005239:Fear; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D016584:Panic Disorder / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D010487:Periaqueductal Gray / Q000473:pathology / Q000503:physiopathology; D010698:Phobic Disorders / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology; D012686:Septal Nuclei / Q000473:pathology / Q000503:physiopathology; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology
chemical_list: D014151:Anti-Anxiety Agents