title: Hypoxia modulates innate immune factors: A review.
abstract: Hypoxia is an important factor for transcriptional regulation of cell metabolism and the adaptation to cellular stress. It modulates the function of phagocytic cells by stimulating surface receptors such as scavenger receptors, toll like receptors and their downstream signaling cascades. In response to hypoxia, innate immune modifiers are upregulated through pathways involving the key immune response master regulator nuclear factor-κB leading to the modulation of inflammatory cytokines. In this review, we highlighted the effects of hypoxia on different innate immune factors and consequences thereof.
authors.affiliation: Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India. Electronic address: kpmpgi@rediffmail.com.
authors.forename: K P
authors.initials: KP
authors.lastname: Mishra
authors.affiliation: Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India.
authors.forename: Lilly
authors.initials: L
authors.lastname: Ganju
authors.affiliation: Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India.
authors.forename: Shashi Bala
authors.initials: SB
authors.lastname: Singh
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D006801:Humans; D000860:Hypoxia / Q000276:immunology*; D007113:Immunity, Innate; D016328:NF-kappa B / Q000276:immunology; D009569:Nitric Oxide / Q000276:immunology; D051117:Scavenger Receptors, Class A / Q000276:immunology; D051197:Toll-Like Receptor 4 / Q000276:immunology
chemical_list: D016207:Cytokines; C495139:MSR1 protein, human; D016328:NF-kappa B; D051117:Scavenger Receptors, Class A; D051197:Toll-Like Receptor 4; D009569:Nitric Oxide
keywords: Hypoxia; Innate immunity; Nitric oxide; Phagocytosis; TLRs