title: Role of cerebral oxygenation for prediction of hypotension after spinal anesthesia for caesarean section.
abstract: To investigate the role of cerebral oxygen saturation (ScO2) for prediction of hypotension after spinal anesthesia for caesarean section. Forty-five parturients undergoing elective caesarean section under spinal anesthesia were selected. Blood pressure, heart rate and pulse oxygen saturation before and after anesthesia were recorded, and the association between changes in ScO2 before and after anesthesia with hypotension after spinal anesthesia was explored. Hypotension occurred in 32 parturients after spinal anesthesia. The decrease in ScO2 after spinal anesthesia in parturients with hypotension was larger than in parturients without hypotension (P < 0.05). The duration from the intrathecal injection to 5 % decrease in ScO2 was shorter than that from the intrathecal injection to the occurrence of hypotension (P < 0.05). The mean time from 5 % decrease in ScO2 to hypotension was 38 s. The area under the receiver operation characteristic curve was 0.83 for decrease in ScO2 for prediction of hypotension (P < 0.05), and the optimal threshold value was 4.5 %. The sensitivity, specificity, positive predictive value and negative predictive value of 4.5 % decrease in ScO2 for prediction of hypotension were 0.75, 0.78, 0.92 and 0.47, respectively. The decrease in ScO2 after spinal anesthesia is associated with hypotension after spinal anesthesia for cesarean section, and may be a clinically useful predictor.
authors.affiliation: Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Anesthesiology, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu Province, China.
authors.forename: Nai-He
authors.initials: NH
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. drhuangsq@163.com.
authors.forename: Shao-Qiang
authors.initials: SQ
authors.lastname: Huang
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D001921:Brain / Q000378:metabolism*; D002585:Cesarean Section / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D010100:Oxygen / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Caesarean section; Cerebral oxygen saturation; Hypotension; Spinal anesthesia