title: Relative risks for comorbidities associated with myotonic dystrophy: A population-based analysis.
abstract: BACKGROUND
  A population-level relative risk assessment for comorbidities associated with myotonic dystrophy has not been performed.
  
  
  METHODS
  In this study we utilized the Utah Population Database to identify patients with myotonic dystrophy in Utah according to ICD-9 coding. Comorbidity cases listed in the medical record were compared with those of the Utah population.
  
  
  RESULTS
  Individuals with myotonic dystrophy were found to possess an increased risk of central and obstructive sleep apnea, hypothyroidism, and intellectual disability. The risk of cardiac conduction disorder is 60 times the population risk.
  
  
  CONCLUSIONS
  This study provides a population-level relative risk assessment of comorbidities in myotonic dystrophy. This allows for improved counseling of patients regarding these increased risks.
authors.affiliation: Department of Neurology, University of Utah School of Medicine, Salt Lake City, 30 N 1900 SOM 3E228, Utah, 84132, USA.
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Johnson
authors.affiliation: Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Abbott
authors.affiliation: Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.|George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Cannon-Albright
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000453:epidemiology*; D053840:Brugada Syndrome; D000075224:Cardiac Conduction System Disease; D002386:Cataract / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D018672:Community Health Planning; D015897:Comorbidity; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005260:Female; D006329:Heart Conduction System / Q000002:abnormalities*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000453:epidemiology*; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000453:epidemiology*; D012893:Sleep Wake Disorders / Q000453:epidemiology*; D014589:Utah / Q000453:epidemiology; D055815:Young Adult
keywords: genetic epidemiology; hypothyroidism; myotonic dystrophy; population; relative risk; sleep apnea