title: Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution.
abstract: OBJECTIVE
  To determine the changes in dry eye disease (DED) severity and the percentage of cells expressing HLA-DR on the ocular surface following treatment with lubricant eyedrops containing polyethylene glycol and propylene glycol (PEG/PG) and the gelling agent hydroxypropyl guar (HP-Guar).
  
  
  METHODS
  Nineteen patients with DED used PEG/PG + HP-Guar eyedrops four times per day for 30 days. Assessments included DED severity (Ocular Surface Disease Index [OSDI], corneal staining, conjunctival staining, tear film break-up time [TFBUT], and Schirmer testing) and impression cytology of the conjunctiva with masked flow cytometry at baseline and at 30 days.
  
  
  RESULTS
  There was a significant decrease in corneal staining (P<0.01), OSDI (P=0.02), and TFBUT (P<0.01) following treatment with PEG/PG + HP-Guar. Results from flow cytometry revealed a significant decrease in cells expressing HLA-DR (P=0.02).
  
  
  CONCLUSIONS
  Treatment with PEG/PG + HP-Guar eyedrops showed improvement in dry eye severity and reduction in surface inflammation as indicated by a reduction in HLA-DR expression.
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Karen B
authors.initials: KB
authors.lastname: Fernandez
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Seth P
authors.initials: SP
authors.lastname: Epstein
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Raynor
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Sheyman
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Morgan L
authors.initials: ML
authors.lastname: Massingale
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Dentone
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Lukas D
authors.initials: LD
authors.lastname: Landegger
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Penny A
authors.initials: PA
authors.lastname: Asbell
keywords: artificial tears; dry eye disease; hydroxypropyl guar; inflammation; lubricating eyedrops; polyethylene glycol; propylene glycol