title: Risk of seizures in children with tectal gliomas.
abstract: The objective of this study was to determine the prevalence of seizures in children with tectal gliomas and to determine if there are common clinical, electroencephalography (EEG), or radiologic findings that predict risk of seizures in these patients. We conducted a retrospective review of all patients with tectal gliomas over a 22-year period at a single institution. Data extraction included sex, age at presentation of tectal glioma and age of presentation with seizures, magnetic resonance imaging (MRI) findings, seizure frequency and semiology, and EEG findings. We identified 79 patients, 66 of whom had adequate imaging and clinical data for further analysis. Eight patients (12.1%) had a history of seizures. Three patients had a clear symptomatic cause of seizures. Three patients were diagnosed with a tectal glioma as an incidental finding after a first seizure. One patient had a history of febrile convulsions. One patient had a generalized seizure 5 years after presenting with macrocephaly. Although the risk of seizure in children with known tectal glioma was relatively high, we did not identify specific clinical, radiologic, EEG, or MRI features that are predictive of increased risk. Thus, in children with tectal gliomas who have seizures, alternative causes for the seizures must be sought.
authors.affiliation: Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, U.S.A.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dabscheck
authors.affiliation: Department of Radiology, Boston Children's Hospital, Boston, Massachusetts, U.S.A.
authors.forename: Sanjay P
authors.initials: SP
authors.lastname: Prabhu
authors.affiliation: Department of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, U.S.A.|Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, U.S.A.
authors.forename: Peter E
authors.initials: PE
authors.lastname: Manley
authors.affiliation: Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, U.S.A.|Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts, U.S.A.
authors.forename: Liliana
authors.initials: L
authors.lastname: Goumnerova
authors.affiliation: Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, U.S.A.|Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, U.S.A.
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: Ullrich
mesh_terms: D000293:Adolescent; D020295:Brain Stem Neoplasms / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D005910:Glioma / Q000453:epidemiology*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000175:diagnosis* / Q000453:epidemiology*; D055815:Young Adult
keywords: Epilepsy; Seizures; Tectal gliomas; Tectum