title: Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model.
abstract: Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs of SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the growth of breast cancer stem cell enriched-mammospheres with increased potency. Furthermore, strigolactone analogs inhibited growth and survival of colon, lung, prostate, melanoma, osteosarcoma and leukemia cancer cell lines. To further examine the anti-cancer activity of SLs in vivo, we have examined their effects on growth and viability of MDA-MB-231 tumor xenografts model either alone or in combination with paclitaxel. We show that strigolactone act as new anti-cancer agents in inhibition of breast cancer in xenograft model. In addition we show that SLs affect the integrity of the microtubule network and therefore may inhibit the migratory phenotype of the highly invasive breast cancer cell lines that were examined.
authors.affiliation: a Institute of Plant Sciences; ARO; Volcani Center ; Bet Dagan , Israel.
authors.forename: Einav
authors.initials: E
authors.lastname: Mayzlish-Gati
authors.affiliation: a Institute of Plant Sciences; ARO; Volcani Center ; Bet Dagan , Israel.|b Faculty of Engineering Sciences; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering ; Ben-Gurion University of the Negev ; Beer-Sheva , Israel.
authors.forename: Dana
authors.initials: D
authors.lastname: Laufer
authors.affiliation: c Department of Human Science ; SNHS; Georgetown University ; Washington, DC USA.
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Grivas
authors.affiliation: a Institute of Plant Sciences; ARO; Volcani Center ; Bet Dagan , Israel.
authors.forename: Julia
authors.initials: J
authors.lastname: Shaknof
authors.affiliation: a Institute of Plant Sciences; ARO; Volcani Center ; Bet Dagan , Israel.|b Faculty of Engineering Sciences; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering ; Ben-Gurion University of the Negev ; Beer-Sheva , Israel.
authors.forename: Amiram
authors.initials: A
authors.lastname: Sananes
authors.affiliation: a Institute of Plant Sciences; ARO; Volcani Center ; Bet Dagan , Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Bier
authors.affiliation: b Faculty of Engineering Sciences; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering ; Ben-Gurion University of the Negev ; Beer-Sheva , Israel.
authors.forename: Shani
authors.initials: S
authors.lastname: Ben-Harosh
authors.affiliation: a Institute of Plant Sciences; ARO; Volcani Center ; Bet Dagan , Israel.
authors.forename: Eduard
authors.initials: E
authors.lastname: Belausov
authors.affiliation: d Department of Oncology ; Georgetown University Medical Center ; Washington, DC USA.|e The Lombardi Comprehensive Cancer Center; Georgetown University Medical Center ; Washington, DC USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Johnson
authors.affiliation: f Department of Chemistry ; University of Turin ; Torino , Italy.
authors.forename: Emma
authors.initials: E
authors.lastname: Artuso
authors.affiliation: g Institute of Animal Sciences; Volcani Center ; Bet Dagan , Israel.
authors.forename: Oshrat
authors.initials: O
authors.lastname: Levi
authors.affiliation: g Institute of Animal Sciences; Volcani Center ; Bet Dagan , Israel.
authors.forename: Ola
authors.initials: O
authors.lastname: Genin
authors.affiliation: f Department of Chemistry ; University of Turin ; Torino , Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Prandi
authors.affiliation: b Faculty of Engineering Sciences; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering ; Ben-Gurion University of the Negev ; Beer-Sheva , Israel.
authors.forename: Isam
authors.initials: I
authors.lastname: Khalaila
authors.affiliation: g Institute of Animal Sciences; Volcani Center ; Bet Dagan , Israel.
authors.forename: Mark
authors.initials: M
authors.lastname: Pines
authors.affiliation: c Department of Human Science ; SNHS; Georgetown University ; Washington, DC USA.|e The Lombardi Comprehensive Cancer Center; Georgetown University Medical Center ; Washington, DC USA.
authors.forename: Ronit I
authors.initials: RI
authors.lastname: Yarden
authors.affiliation: a Institute of Plant Sciences; ARO; Volcani Center ; Bet Dagan , Israel.
authors.forename: Yoram
authors.initials: Y
authors.lastname: Kapulnik
authors.affiliation: a Institute of Plant Sciences; ARO; Volcani Center ; Bet Dagan , Israel.
authors.forename: Hinanit
authors.initials: H
authors.lastname: Koltai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D002470:Cell Survival / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007783:Lactones / Q000494:pharmacology* / Q000627:therapeutic use; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D017239:Paclitaxel / Q000494:pharmacology* / Q000627:therapeutic use; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; D007783:Lactones; D017239:Paclitaxel
keywords: SLs, strigolactones.; breast cancer; cell motility, microtubule; plant hormone; strigolactone; xenograft