title: Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis.
abstract: Endometriosis is a degenerative process due to a chronic inflammatory damage leading to extracellular matrix components deposition and glandular fibrosis. It is known that mesenchymal stem cells secrete a wide range of bioactive molecules, some of them modulating the immune inflammatory response, and others providing regeneration and remodeling of injured tissue. We have performed in vitro experiments in order to analyze the capability of allogenic equine adipose-derived stem cells (ADSCs) to infiltrate mares' endometrial tissues and to stimulate the expression of cytokines and metallopeptidases. Differences in the biologic response to the exposure to ADSCs between pathological and healthy endometrial tissue have been identified. These results could challenge researchers to progress forward with future studies for the development of a biological therapy with a possible application in translational medicine.
authors.affiliation: Department of Veterinary Clinical Sciences, Viale dell'Università 16, 35100 Padua, Italy.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Falomo
authors.affiliation: Department of Biomedical Sciences, University of Padua, Via G. Colombo 3, 35100 Padua, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Ferroni
authors.affiliation: Department of Neurosciences, University of Padua, Via Giustiniani 2, 35100 Padua, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Tocco
authors.affiliation: Department of Biomedical Sciences, University of Padua, Via G. Colombo 3, 35100 Padua, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Gardin
authors.affiliation: Department of Biomedical Sciences, University of Padua, Via G. Colombo 3, 35100 Padua, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Zavan
mesh_terms: D000273:Adipose Tissue / Q000276:immunology*; D064591:Allografts; D000818:Animals; D016207:Cytokines / Q000276:immunology; D004715:Endometriosis / Q000276:immunology / Q000628:therapy / Q000662:veterinary; D005260:Female; D018093:Gelatinases / Q000276:immunology; D006734:Horse Diseases / Q000276:immunology / Q000628:therapy; D006736:Horses; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology*
chemical_list: D016207:Cytokines; D018093:Gelatinases