title: Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study.
abstract: Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.
authors.affiliation: Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Kurth
authors.affiliation: Hôpital Saint-Antoine, Paris.
authors.forename: Michel
authors.initials: M
authors.lastname: Develoux
authors.affiliation: Section Tropical Medicine and Clinical International Health, Division of Infectious and Tropical Diseases, Department of Medicine, University Hospital Centre, Bordeaux, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Mechain
authors.affiliation: Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Clerinx
authors.affiliation: Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Italy.
authors.forename: Spinello
authors.initials: S
authors.lastname: Antinori
authors.affiliation: Infectious Diseases Unit, Herlev University Hospital, Copenhagen, Denmark.
authors.forename: Ida E
authors.initials: IE
authors.lastname: Gjørup
authors.affiliation: ISGlobal, Barcelona Centre for International Health Research, Spain.
authors.forename: Joaquím
authors.initials: J
authors.lastname: Gascon
authors.affiliation: National Centre for Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
authors.forename: Kristine
authors.initials: K
authors.lastname: Mørch
authors.affiliation: National Institute of Infectious Diseases Lazzaro Spallanzani, Rome, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Nicastri
authors.affiliation: Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Ramharter
authors.affiliation: SOD Malattie Infettive e Tropicali, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bartoloni
authors.affiliation: Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
authors.forename: Leo
authors.initials: L
authors.lastname: Visser
authors.affiliation: Department of Internal Medicine I, Section Tropical Medicine, University Medical Center Hamburg-Eppendorf Department of Clinical Research, Bernhard Nocht Institute for Tropical Medicine, Hamburg.
authors.forename: Thierry
authors.initials: T
authors.lastname: Rolling
authors.affiliation: Institute of Public Health, University of Heidelberg Institute of Tropical Medicine, University of Tübingen, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Zanger
authors.affiliation: Travel Medicine Unit, Department of Infectious Diseases, Amedeo di Savoia Hospital-ASLTO2, Turin, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Calleri
authors.affiliation: Tropical Medicine Unit, Hospital de Poniente, El Ejido, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Salas-Coronas
authors.affiliation: Department of Infectious Diseases, Aalborg University Hospital, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Nielsen
authors.affiliation: Department of Internal Medicine II, Section Infectious diseases and Tropical Medicine, University Hospital Frankfurt/Main, Germany.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Just-Nübling
authors.affiliation: Swiss Tropical and Public Health Institute, Basel.
authors.forename: Andreas
authors.initials: A
authors.lastname: Neumayr
authors.affiliation: Department of Infectious Diseases, Bern University Hospital and University of Bern, Switzerland.
authors.forename: Anna
authors.initials: A
authors.lastname: Hachfeld
authors.affiliation: Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
authors.forename: Matthias L
authors.initials: ML
authors.lastname: Schmid
authors.affiliation: Clinica Luganese, Lugano, Switzerland.
authors.forename: Pietro
authors.initials: P
authors.lastname: Antonini
authors.affiliation: Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Pongratz
authors.affiliation: Comprehensive Infectious Diseases Center, Department of Internal Medicine III, Ulm University Hospital, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Kern
authors.affiliation: Centro Hospitalar e Universitário de Coimbra, Portugal.
authors.forename: José
authors.initials: J
authors.lastname: Saraiva da Cunha
authors.affiliation: Hospital Universitari Joan XXIII, Tarragona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Soriano-Arandes
authors.affiliation: Abteilung für Infektions- und Tropenmedizin, Medizinische Poliklinik, University of Munich, Germany.
authors.forename: Mirjam
authors.initials: M
authors.lastname: Schunk
authors.affiliation: Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Suttorp
authors.affiliation: Swiss Tropical and Public Health Institute, Basel.
authors.forename: Christoph
authors.initials: C
authors.lastname: Hatz
authors.affiliation: Swiss Tropical and Public Health Institute, Basel.
authors.forename: Thomas
authors.initials: T
authors.lastname: Zoller
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins / Q000008:administration & dosage*; D000077332:Artesunate; D005060:Europe; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D011803:Quinine / Q000008:administration & dosage; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate; D011803:Quinine
keywords: Plasmodium falciparum; artesunate; clinical study; quinine; severe malaria