title: Baseline overall health-related quality of life predicts the 10-year incidence of cardiovascular events in a Chinese population.
abstract: OBJECTIVE
  To determine the relationship between baseline overall HRQOL as well as domain-specific HRQOL and incident cardiovascular (CV) events over 10 years of follow-up in a Chinese general population.
  
  
  METHODS
  We examined the above link using data from a prospective cohort study, conducted between 2002 and 2012 in 11 villages of Beijing. HRQOL was assessed using Chinese 35-item quality of life instrument, and CV risk factors were recorded in either 2002 or 2005. Subjects were followed through the end of the study period, or until they were censored due to an incident CV event [including myocardial infarction (MI) and stroke] or loss to follow-up.
  
  
  RESULTS
  A total of 1739 participants were eligible to be included in the current study [female 64.2 %, age 57.7 (8.4) years]. There were a total of 190 CV events during the follow-up (14,364 total person-years). Participants in the bottom 20 % had 85 % increase in risk of CV event [hazard ratio (HR) 1.85; 95 % CI 1.14-3.02] compared to those in top 20 % of overall HRQOL, after adjusting for sex, age, education, marital status, smoking, alcohol consumption, being physically active, hypertension, diabetes, high cholesterol, and obesity. Among the six HRQOL domains, the independence domain had the largest effect size (fully adjusted HR 2.91; 95 % CI 1.67-5.07), followed by physical domain (HR 1.66; 95 % CI 1.03-2.67). Other domains did not predict the incidence CV events in this cohort.
  
  
  CONCLUSIONS
  While overall lower HRQOL predicts subsequent risk of stroke and MI events, this appeared to be driven mainly by the independence domain.
authors.affiliation: Peking University Clinical Research Institute, No. 113 Room, No. 6 Building, Xue Yuan Lu 38#, Haidian District, Beijing, 100191, People's Republic of China. gxie@bjmu.edu.cn.
authors.forename: Gaoqiang
authors.initials: G
authors.lastname: Xie
authors.affiliation: Peking University Clinical Research Institute, No. 113 Room, No. 6 Building, Xue Yuan Lu 38#, Haidian District, Beijing, 100191, People's Republic of China.
authors.forename: Henyun
authors.initials: H
authors.lastname: Zou
authors.affiliation: Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Scotland, UK.|Norwich Research Park Cardiovascular Research Group, Norwich Medical School, University of East Anglia, Norwich, UK.|Clinical Gerontology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.|Stroke Research Group, Norfolk and Norwich University Hospital, Norwich, UK.
authors.forename: Phyo Kyaw
authors.initials: PK
authors.lastname: Myint
authors.affiliation: Shijingshan Center for Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Shi
authors.affiliation: Shijingshan Center for Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Fuxiu
authors.initials: F
authors.lastname: Ren
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Beijing, People's Republic of China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Peking University Clinical Research Institute, No. 113 Room, No. 6 Building, Xue Yuan Lu 38#, Haidian District, Beijing, 100191, People's Republic of China. wuyf@bjmu.edu.cn.|Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, People's Republic of China. wuyf@bjmu.edu.cn.
authors.forename: Yangfeng
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D000068476:Beijing / Q000453:epidemiology; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006304:Health Status; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*; D011795:Surveys and Questionnaires
keywords: Cardiovascular incidence; Health-related quality of life; Myocardial infarction; Prospective cohort study; Stroke