title: Chance and Necessity in Bacillus subtilis Development.
abstract: Bacillus subtilis is an important model bacterium for the study of developmental adaptations that enhance survival in the face of fluctuating environmental challenges. These adaptations include sporulation, biofilm formation, motility, cannibalism, and competence. Remarkably, not all the cells in a given population exhibit the same response. The choice of fate by individual cells is random but is also governed by complex signal transduction pathways and cross talk mechanisms that reinforce decisions once made. The interplay of stochastic and deterministic mechanisms governing the selection of developmental fate on the single-cell level is discussed in this article.
authors.affiliation: UMR1319 Micalis, Bat. Biotechnologie (440), INRA, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mirouze
authors.affiliation: Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
authors.forename: David
authors.initials: D
authors.lastname: Dubnau