title: Compensation of drift by using a multichannel integrated Young interferometer.
abstract: Polymer-based integrated Young interferometer (YI) sensor chips have proven to be sensitive and have potential to be mass-manufactured. The sensing method is however, disturbed by the mechanical drifts, thus requiring well stabilized and isolated measurement setups that limit its applicability to low-cost readers for rapid diagnostics. In this paper we derive a method for the compensation of mechanical drift by using a multichannel integrated YI chip having two reference channels. The compensation method was demonstrated by quantitative measurements with a three-channel integrated polymeric YI sensor chip using an undisturbed and a mechanically disturbed setup. By applying the compensation method, the intrinsic drift of the undisturbed setup was reduced up to 84%. With the mechanically disturbed setup, the sample-induced phase-change responses were separated up to a 161 times larger disturbed signal.
authors.forename: Sanna
authors.initials: S
authors.lastname: Aikio
authors.forename: Marianne
authors.initials: M
authors.lastname: Hiltunen
authors.forename: Jussi
authors.initials: J
authors.lastname: Hiltunen
mesh_terms: D004867:Equipment Design; D005947:Glucose / Q000737:chemistry; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007368:Interferometry / Q000379:methods*; D019095:Point-of-Care Systems; D011108:Polymers / Q000737:chemistry*; D012031:Refractometry; D012815:Signal Processing, Computer-Assisted; D013314:Stress, Mechanical; D014867:Water / Q000737:chemistry
chemical_list: D011108:Polymers; D014867:Water; D005947:Glucose