title: DNA-caged gold nanoparticles for controlled release of doxorubicin triggered by a DNA enzyme and pH.
abstract: DNA polyhedron-caged gold nanoparticles (AuNP) were self-assembled using four-point-star DNAs, with three strands hybridizing to each other and the fourth strand attaching to the AuNPs. The DNA-caged AuNPs can work as nanocarriers for doxorubicin, and controlled release behaviour can be triggered by both a DNA enzyme and by the pH value.
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Jiangning, Nanjing, Jiangsu 211189, P. R. China. yj@seu.edu.cn.
authors.forename: Zi-Mou
authors.initials: ZM
authors.lastname: Zhang
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Gao
authors.forename: Zhi-Fei
authors.initials: ZF
authors.lastname: Wang
authors.forename: Bai-Wang
authors.initials: BW
authors.lastname: Sun
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000378:metabolism; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D005090:Exodeoxyribonucleases / Q000378:metabolism*; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008958:Models, Molecular
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D006046:Gold; D004317:Doxorubicin; D004247:DNA; D005090:Exodeoxyribonucleases; C046264:gene b exonuclease