title: Past, Present, and Future of Lipid Resuscitation Therapy.
abstract: Lipid resuscitation therapy was identified in 1998 as an effective treatment for local anesthetic systemic toxicity in an animal model. Since the original observation, the field has progressed tremendously with successful clinical translation and expansion of use to treatment of other types of drug overdose. Recent work has expanded our understanding of the mechanism of this novel treatment, one that includes both a dynamic scavenging component and direct cardiotonic effect. In this review, we discuss the past, present, and future of lipid resuscitation therapy with a focus on our understanding of the mechanism and directions that the field is moving, both from a clinical and basic research side.
authors.affiliation: Department of Anesthesiology, University of Illinois College of Medicine, Chicago, Illinois Research & Development Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois Neuroscience Program, University of Illinois at Chicago, Chicago, Illinois mfetti3@uic.edu.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Fettiplace
authors.affiliation: Department of Anesthesiology, University of Illinois College of Medicine, Chicago, Illinois Research & Development Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois.
authors.forename: Guy
authors.initials: G
authors.lastname: Weinberg
mesh_terms: D000779:Anesthetics, Local / Q000009:adverse effects; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use; D062787:Drug Overdose / Q000628:therapy*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008055:Lipids / Q000494:pharmacology / Q000627:therapeutic use*; D012151:Resuscitation / Q000379:methods*
chemical_list: D000779:Anesthetics, Local; D002316:Cardiotonic Agents; D005217:Fat Emulsions, Intravenous; D008055:Lipids
keywords: Intralipid; bupivacaine; lipid emulsion; local anesthetic; overdose; toxicity