title: Correlation of high-sensitivity C-reactive protein and carotid plaques with coronary artery disease in elderly patients.
abstract: The aim of this study was to explore the correlation of high-sensitivity C-reactive protein (hs-CRP) and carotid plaques with the severity of coronary artery disease (CAD). A total of 140 patients with angina who underwent coronary angiography were selected and divided into a single-vessel disease group (n=11), double-vessel disease group (n=18), multi-vessel disease group (n=71) and control group (n=40). Color Doppler ultrasound was applied to measure the intima-media thickness (IMT) of the common carotid artery (CCA) and carotid bifurcation, and to record the location and number of carotid plaques. The serum hs-CRP level was also determined. Compared with the control and single-vessel disease groups, the multi-vessel disease group showed significantly higher IMT of the CCA (P<0.05). The serum hs-CRP level was highest in the multi-vessel disease group (P<0.01). The hs-CRP level and carotid plaque characteristics were found to correlate closely with the severity of CAD. Therefore, they may be used to improve the prediction of CAD severity in elderly patients.
authors.affiliation: Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Yuanping
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Niu
authors.affiliation: Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xue
authors.affiliation: Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Qianmei
authors.initials: Q
authors.lastname: Sun
keywords: carotid plaque; coronary artery disease; elderly patients; high-sensitivity C-reactive protein