title: Anti-inflammatory Effects of Perioperative Dexmedetomidine Administered as an Adjunct to General Anesthesia: A Meta-analysis.
abstract: The aim of this meta-analysis is to examine the effects of dexmedetomidine on serum inflammatory markers when administered perioperatively. We searched multiple electronic databases for relevant research papers, and carried out meta-analyses of weighted mean differences and interpreted in the light of statistical heterogeneity (I(2)). Fifteen RCTs recruiting 641 patients were included. Dexmedetomidine treatment significantly decreased interleukin-6 (IL-6), IL-8 and tumor necrosis factor-alpha (TNF-α) levels with mean differences [95% CI] in the changes from baseline between dexmedetomidine treated and controls of -25.14 [-35.29, -15.00]; P < 0.00001 (for IL-6), -5.69 [-10.77, -0.60]; P < 0.04 (for IL-8), and -20.30 [-30.93, -9.67]; P < 0.0002 (for TNF-α) immediately after surgery; and -41.55 [-57.41, -25.70]; P < 0.00001 (IL-6), -6.46 [-10.83, -2.08]; P < 0.005 (IL-8), and -14.67 [-22.61, -6.73]; P < 0.0003 (TNF-α) on postoperative day 1 (random effects). IL-10 levels were found to increase significantly a day after surgery (8.33 [3.31, 13.36]; P = 0.001). Subgroup analyses did not reveal significant differences. In conclusion, perioperative adjunctive use of dexmedetomidine substantially decreases serum IL-6, IL-8 and TNF-α levels.
authors.affiliation: Department of Anesthesiology, Jinan General Hospital, PLA Jinan Military Area Command, Jinan 250031, Shandong, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong, China.
authors.forename: Yalan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, No. 261 Hospital of PLA, Beijing, China.
authors.forename: Shushi
authors.initials: S
authors.lastname: Tian
authors.affiliation: Department of Anesthesiology, Jinan General Hospital, PLA Jinan Military Area Command, Jinan 250031, Shandong, China.
authors.forename: Huixia
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The People's Hospital of Zhangqiu, Zhangqiu 250200, Henan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, Yancheng City No.1 People's Hospital, Yancheng 224005, Jiangsu, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Jinan General Hospital, PLA Jinan Military Area Command, Jinan 250031, Shandong, China.
authors.forename: Chengjie
authors.initials: C
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000379:methods; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D020927:Dexmedetomidine / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood / Q000188:drug therapy*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008875:Middle Aged; D019990:Perioperative Care / Q000379:methods; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D020927:Dexmedetomidine