title: Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses.
abstract: Interferon (IFN) treatment induces the expression of hundreds of IFN-stimulated genes (ISGs). However, only a selection of their products have been demonstrated to be responsible for the inhibition of rhabdovirus replication in cultured cells; and only a few have been shown to play a role in mediating the antiviral response in vivo using gene knockout mouse models. IFNs inhibit rhabdovirus replication at different stages via the induction of a variety of ISGs. This review will discuss how individual ISG products confer resistance to rhabdoviruses by blocking viral entry, degrading single stranded viral RNA, inhibiting viral translation or preventing release of virions from the cell. Furthermore, this review will highlight how these viruses counteract the host IFN system.
authors.affiliation: Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS UMR 9198, Université Paris-Sud, Gif-sur-Yvette 91190, France. danielle.blondel@vms.cnrs-gif.fr.
authors.forename: Danielle
authors.initials: D
authors.lastname: Blondel
authors.affiliation: INSERM UMR-S 1124, Université Paris Descartes, Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS), 75270 Paris Cedex 6, France. ghizlane.maarifi@parisdescartes.fr.
authors.forename: Ghizlane
authors.initials: G
authors.lastname: Maarifi
authors.affiliation: INSERM UMR-S 1124, Université Paris Descartes, Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS), 75270 Paris Cedex 6, France. sebastien.nisole@inserm.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Nisole
authors.affiliation: INSERM UMR-S 1124, Université Paris Descartes, Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS), 75270 Paris Cedex 6, France. mounira.chelbi-alix@parisdescartes.fr.
authors.forename: Mounira K
authors.initials: MK
authors.lastname: Chelbi-Alix
mesh_terms: D000818:Animals; D006801:Humans; D007372:Interferons / Q000235:genetics / Q000276:immunology; D012209:Rhabdoviridae / Q000235:genetics / Q000502:physiology*; D018353:Rhabdoviridae Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology
chemical_list: D007372:Interferons
keywords: ISG; interferon; rabies virus; rhabdoviruses; vesicular stomatitis virus