title: Evaluation in usual practice of the bevacizumab-FOLFIRI combination for the first-line treatment of patients with unresectable metastatic colorectal cancer treated in 2006: focus on resected patients and oncogeriatrics: AVASTIN OUEST cohort of the Observatory of Cancer of the Brittany and Pays de la Loire Areas (Observatoire dédié au Cancer Bretagne / Pays de la Loire).
abstract: BACKGROUND
  In 2006, bevacizumab, a targeted therapy agent was combined with FOLFIRI for the firstline treatment of patients with unresectable metastatic colorectal cancer.
  
  
  RESULTS
  A study on a homogenous series of 111 patients from the Brittany and Pays de la Loire areas who received bevacizumab-FOLFIRI as first-line treatment in 2006 showed the following results: 51 responses, 29 stabilisations, 21 progressions and 10 cases of toxicity prior to assessment. Median overall survival (OS) was 25.1 months and median progression-free survival was 10.2 months. Surgery secondary to treatment tripled median OS which reached 59.2 months in resected patients versus 18.8 months in unresected patients. Comparison of patients aged more or less than 70 years showed no differences in terms of benefits or risks.
  
  
  CONCLUSIONS
  Bevacizumab-FOLFIRI could be administered as part of a routine care protocol to elderly patients previously evaluated by a geriatric assessment and validated by a multidisciplinary staff.
authors.affiliation: CHU Brest Morvan, Brest, France ; Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Metges
authors.affiliation: CHU Brest Morvan, Brest, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Lebot
authors.affiliation: CH La Roche-Sur-Yon, La Roche-sur-Yon, France.
authors.forename: R
authors.initials: R
authors.lastname: Faroux
authors.affiliation: CH La Roche-Sur-Yon, La Roche-sur-Yon, France.
authors.forename: F
authors.initials: F
authors.lastname: Riaud
authors.affiliation: ICO Paul Papin, Angers, France ; Fondateur de l'Observatoire dédié au cancer, Bretagne Pays de la Loire (ex-OMIT B PL), Rennes, France.
authors.forename: E
authors.initials: E
authors.lastname: Gamelin
authors.affiliation: ICO Paul Papin, Angers, France.
authors.forename: O
authors.initials: O
authors.lastname: Capitain
authors.affiliation: ICO Paul Papin, Angers, France.
authors.forename: V
authors.initials: V
authors.lastname: Guérin Meyer
authors.affiliation: ICO Paul Papin, Angers, France.
authors.forename: P
authors.initials: P
authors.lastname: Leynia
authors.affiliation: ICO René Gauducheau, Nantes, France ; Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: J Y
authors.initials: JY
authors.lastname: Douillard
authors.affiliation: ICO René Gauducheau, Nantes, France.
authors.forename: H
authors.initials: H
authors.lastname: Senellart
authors.affiliation: ICO René Gauducheau, Nantes, France.
authors.forename: S
authors.initials: S
authors.lastname: Rochard
authors.affiliation: ICO René Gauducheau, Nantes, France.
authors.forename: C
authors.initials: C
authors.lastname: Louvigné
authors.affiliation: ICO René Gauducheau, Nantes, France.
authors.forename: L
authors.initials: L
authors.lastname: Campion
authors.affiliation: Centre Jean Bernard/Clinique Victor-Hugo, Le Mans, France.
authors.forename: O
authors.initials: O
authors.lastname: Dupuis
authors.affiliation: Centre Jean Bernard/Clinique Victor-Hugo, Le Mans, France.
authors.forename: C
authors.initials: C
authors.lastname: Grollier
authors.affiliation: Clinique Pasteur, Brest, France.
authors.forename: N A
authors.initials: NA
authors.lastname: Achour
authors.affiliation: Clinique Pasteur, Brest, France.
authors.forename: B
authors.initials: B
authors.lastname: Person
authors.affiliation: CRLCC, Eugène-Marquis, Rennes, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Raoul
authors.affiliation: CRLCC, Eugène-Marquis, Rennes, France.
authors.forename: E
authors.initials: E
authors.lastname: Boucher
authors.affiliation: CRLCC, Eugène-Marquis, Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Bertrand
authors.affiliation: Centre Catherine-de-Sienne, Nantes, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Ramée
authors.affiliation: Centre Catherine-de-Sienne, Nantes, France.
authors.forename: L
authors.initials: L
authors.lastname: Guivarch
authors.affiliation: Clinique Armoricaine de Radiologie, Saint-Brieuc, France ; Polyclinique Trégor-Lannion, Lannion, France.
authors.forename: P L
authors.initials: PL
authors.lastname: Etienne
authors.affiliation: Clinique Armoricaine de Radiologie, Saint-Brieuc, France.
authors.forename: S
authors.initials: S
authors.lastname: Roussel
authors.affiliation: CH Saint-Malo, Saint-Malo, France.
authors.forename: H
authors.initials: H
authors.lastname: Desclos
authors.affiliation: CH Saint-Malo, Saint-Malo, France.
authors.forename: M N
authors.initials: MN
authors.lastname: Julien
authors.affiliation: CH Saint-Malo, Saint-Malo, France.
authors.forename: M I
authors.initials: MI
authors.lastname: Labarre
authors.affiliation: Hôpital Privé Océane/Centre Saint Yves Vannes, Vannes, France.
authors.forename: V
authors.initials: V
authors.lastname: Klein
authors.affiliation: Hôpital Privé Océane/Centre Saint Yves Vannes, Vannes, France ; Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: R
authors.initials: R
authors.lastname: Bessard
authors.affiliation: CH Laval, Laval, France.
authors.forename: C
authors.initials: C
authors.lastname: Stampfli
authors.affiliation: CH Laval, Laval, France.
authors.forename: F
authors.initials: F
authors.lastname: Royet
authors.affiliation: CH Landerneau, Landerneau, France.
authors.forename: J
authors.initials: J
authors.lastname: Faycal
authors.affiliation: CH Landerneau, Landerneau, France.
authors.forename: S
authors.initials: S
authors.lastname: Gouva
authors.affiliation: CH Lannion Trestel, Lannion, France.
authors.forename: G
authors.initials: G
authors.lastname: Le Bihan
authors.affiliation: CH Lannion Trestel, Lannion, France.
authors.forename: M
authors.initials: M
authors.lastname: Couturier
authors.affiliation: CH Morlaix, Morlaix, France.
authors.forename: A
authors.initials: A
authors.lastname: Gourlaouen
authors.affiliation: CH Morlaix, Morlaix, France.
authors.forename: C
authors.initials: C
authors.lastname: Bertholom
authors.affiliation: CH Saint-Brieuc, Saint-Brieuc, France.
authors.forename: M
authors.initials: M
authors.lastname: Porneuf
authors.affiliation: CH Saint-Brieuc, Saint-Brieuc, France.
authors.forename: E
authors.initials: E
authors.lastname: Jobard
authors.affiliation: CH Saint-Brieuc, Saint-Brieuc, France.
authors.forename: E
authors.initials: E
authors.lastname: Peguet
authors.affiliation: CH Vannes-Auray, Auray, France.
authors.forename: D
authors.initials: D
authors.lastname: Grasset
authors.affiliation: CH Vannes-Auray, Auray, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Bouret
authors.affiliation: CH Vannes-Auray, Auray, France.
authors.forename: V
authors.initials: V
authors.lastname: Bicheler
authors.affiliation: CH Vannes-Auray, Auray, France.
authors.forename: A
authors.initials: A
authors.lastname: Ulvoas
authors.affiliation: CHP Saint Grégoire, Saint Grégoire, France.
authors.forename: L
authors.initials: L
authors.lastname: Miglianico
authors.affiliation: CHP Saint Grégoire, Saint Grégoire, France.
authors.forename: C
authors.initials: C
authors.lastname: Chouzenoux
authors.affiliation: Clinique Mutualiste de l'Estuaire, Saint-Nazaire, France.
authors.forename: P
authors.initials: P
authors.lastname: Deguiral
authors.affiliation: Clinique Mutualiste de l'Estuaire, Saint-Nazaire, France.
authors.forename: L
authors.initials: L
authors.lastname: Derenne
authors.affiliation: Polyclinique du Maine/Centre Mallet Proux Laval, Laval, France.
authors.forename: D
authors.initials: D
authors.lastname: Martin
authors.affiliation: Polyclinique du Maine/Centre Mallet Proux Laval, Laval, France.
authors.forename: P Michel
authors.initials: PM
authors.lastname: Langlet
authors.affiliation: Polyclinique du Maine/Centre Mallet Proux Laval, Laval, France.
authors.forename: C
authors.initials: C
authors.lastname: Bodin
authors.affiliation: CH Haut Anjou Château Gontier, Château Gontier, France.
authors.forename: V
authors.initials: V
authors.lastname: Rossi
authors.affiliation: CH Haut Anjou Château Gontier, Château Gontier, France.
authors.forename: S
authors.initials: S
authors.lastname: Barré
authors.affiliation: CH Le Mans, Le Mans, France.
authors.forename: O
authors.initials: O
authors.lastname: Cojocarasu
authors.affiliation: CH Le Mans, Le Mans, France.
authors.forename: C
authors.initials: C
authors.lastname: Naveau Ploux
authors.affiliation: CH Le Mans, Le Mans, France ; Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Vidal
authors.affiliation: CH Sud Lorient Hennebont, Hennebont, France.
authors.forename: I
authors.initials: I
authors.lastname: Cumin
authors.affiliation: CH Sud Lorient Hennebont, Hennebont, France.
authors.forename: J
authors.initials: J
authors.lastname: Egreteau
authors.affiliation: CH Sud Lorient Hennebont, Hennebont, France.
authors.forename: A
authors.initials: A
authors.lastname: Brouard
authors.affiliation: CHU Hôtel-Dieu, Nantes, France.
authors.forename: T
authors.initials: T
authors.lastname: Matysiak Budnik
authors.affiliation: CHU Hôtel-Dieu, Nantes, France.
authors.forename: P
authors.initials: P
authors.lastname: Thomaré
authors.affiliation: CH Douarnenez, Douarnenez, France.
authors.forename: A S
authors.initials: AS
authors.lastname: Le Bris Michel
authors.affiliation: CH Douarnenez, Douarnenez, France.
authors.forename: G
authors.initials: G
authors.lastname: Piriou
authors.affiliation: CH Douarnenez, Douarnenez, France.
authors.forename: R
authors.initials: R
authors.lastname: Largeau
authors.affiliation: Polyclinique du Parc Cholet, Cholet, France.
authors.forename: C
authors.initials: C
authors.lastname: Elhannani
authors.affiliation: Polyclinique du Parc Cholet, Cholet, France.
authors.forename: E
authors.initials: E
authors.lastname: Crespeau
authors.affiliation: Polyclinique Trégor-Lannion, Lannion, France.
authors.forename: F
authors.initials: F
authors.lastname: Suberville
authors.affiliation: Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: H
authors.initials: H
authors.lastname: Bourgeois
authors.affiliation: Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Riche
authors.affiliation: Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: D Déniel
authors.initials: DD
authors.lastname: Lagadec
authors.affiliation: Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: F
authors.initials: F
authors.lastname: Marhuenda
authors.affiliation: Observatoire dédié au Cancer de l'OMEDIT Bretagne et de l'OMEDIT Pays de la Loire, Rennes, France.
authors.forename: F
authors.initials: F
authors.lastname: Grudé
keywords: Bevacizumab; Cohort; Daily practice; Elderly patients; Liver surgical resection; Metastatic colorectal cancer