title: [Genome organization and life cycle of the hepatitis c virus].
abstract: The review summarizes the current data about the hepatitis C viral genome and polyprotein organization. The functional role of the structural and non-structural viral proteins including their interaction with cellular regulatory proteins and cell structural elements is discussed. Specific peculiarities of the life cycle of the hepatitis C virus important for the understanding of the viral hepatitis C pathogenesis are summarized.
authors.forename: O V
authors.initials: OV
authors.lastname: Kalinina
authors.forename: A V
authors.initials: AV
authors.lastname: Dmitriev
mesh_terms: D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D006526:Hepatitis C / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*; D014771:Virion / Q000737:chemistry / Q000648:ultrastructure; D012324:RNA-Dependent RNA Polymerase
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D014759:Viral Envelope Proteins; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C087035:E1 protein, Hepatitis C virus; C455041:NS4A cofactor peptide, Hepatitis C virus; C080107:NS4B protein, flavivirus; C107619:glycoprotein E2, GB virus C; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase