title: Relationships of Early And Late Glycemic Responses With Gastric Emptying During An Oral Glucose Tolerance Test.
abstract: BACKGROUND
  The early glycemic response during a 75-g oral glucose tolerance test (OGTT) is directly related to the rate of gastric emptying (GE). There is little information about the effect of GE on the blood glucose at either 60 min (a predictor of diabetes) or 120 min (used diagnostically).
  
  
  OBJECTIVE
  This study aimed to evaluate the relationships between glycemic responses at 30, 60, and 120 min and GE following a 75-g OGTT in subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes (T2D).
  
  
  METHODS
  Eighty-two subjects in the general community without diabetes (57 NGT, 25 IGT) and 16 with T2D consumed a 75-g glucose drink labeled with (99m)Tc-sulfur colloid. GE (by scintigraphy) and glycemia were measured from t = 0-120 min and relationships between blood glucose (absolute, change from baseline, and area under the curve) and GE at 30, 60, and 120 min determined.
  
  
  RESULTS
  There were no differences in GE. There were relationships between the blood glucose at 30 min and GE (NGT: r = 0.40; P < .01; IGT: r = 0.49; P = .02; T2D: r = 0.62; P = .01). There was also a relationship between the blood glucose at 60 min and GE in IGT (r = 0.52; P = .02) and T2D (r = 0.77; P < .01), but not NGT (r = 0.16; P = .24). In NGT, there was an inverse relationship between blood glucose at 120 min and GE (r = -0.30; P = .02), but not in IGT (r = 0.05; P = .82) or T2D (r = 0.37; P = .16).
  
  
  CONCLUSIONS
  GE is a determinant of the glycemic response to an OGTT in NGT, IGT, and T2D but these relationships differ and are time dependent.
authors.affiliation: Discipline of Medicine (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Royal Adelaide Hospital, Adelaide 5000, Australia; and Centre of Research Excellence in Translating Nutritional Science to Good Health (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia.
authors.forename: Chinmay S
authors.initials: CS
authors.lastname: Marathe
authors.affiliation: Discipline of Medicine (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Royal Adelaide Hospital, Adelaide 5000, Australia; and Centre of Research Excellence in Translating Nutritional Science to Good Health (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Horowitz
authors.affiliation: Discipline of Medicine (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Royal Adelaide Hospital, Adelaide 5000, Australia; and Centre of Research Excellence in Translating Nutritional Science to Good Health (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia.
authors.forename: Laurence G
authors.initials: LG
authors.lastname: Trahair
authors.affiliation: Discipline of Medicine (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Royal Adelaide Hospital, Adelaide 5000, Australia; and Centre of Research Excellence in Translating Nutritional Science to Good Health (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Wishart
authors.affiliation: Discipline of Medicine (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Royal Adelaide Hospital, Adelaide 5000, Australia; and Centre of Research Excellence in Translating Nutritional Science to Good Health (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia.
authors.forename: Michelle
authors.initials: M
authors.lastname: Bound
authors.affiliation: Discipline of Medicine (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Royal Adelaide Hospital, Adelaide 5000, Australia; and Centre of Research Excellence in Translating Nutritional Science to Good Health (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia.
authors.forename: Kylie
authors.initials: K
authors.lastname: Lange
authors.affiliation: Discipline of Medicine (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Royal Adelaide Hospital, Adelaide 5000, Australia; and Centre of Research Excellence in Translating Nutritional Science to Good Health (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Rayner
authors.affiliation: Discipline of Medicine (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Royal Adelaide Hospital, Adelaide 5000, Australia; and Centre of Research Excellence in Translating Nutritional Science to Good Health (C.S.M., M.H., L.G.T., J.M.W., M.B., K.L., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Jones
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001786:Blood Glucose