title: Butyryl-cholinesterase is related to muscle mass and strength. A new biomarker to identify elderly subjects at risk of sarcopenia.
abstract: OBJECTIVE
  To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength.
  
  
  METHODS
  Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment.
  
  
  RESULTS
  b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p < 0.01). Linear regression analysis demonstrated that b-CHE is linearly related with grip strength and muscular mass both in men and women (r = 0.45 and r = 0.33, p < 0.01; r = 0.55 and r = 0.39, p < 0.01; respectively). Multivariate analysis confirms this analysis.
  
  
  CONCLUSIONS
  b-CHE is related to muscle mass and strength in elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy.|IRCCS Salvatore Maugeri Foundation, Scientific Institute of Telese, Benevento, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Cacciatore
authors.affiliation: Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.|IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: David
authors.initials: D
authors.lastname: Della-Morte
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Basile
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Curcio
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Liguori
authors.affiliation: Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Roselli
authors.affiliation: Division of Geriatrics, AON SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Gargiulo
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy.|IRCCS Salvatore Maugeri Foundation, Scientific Institute of Veruno, Novara, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Galizia
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Bonaduce
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Abete
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D002091:Butyrylcholinesterase / Q000032:analysis*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000502:physiology*; D055948:Sarcopenia / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D002091:Butyrylcholinesterase
keywords: biomarkers; inflammation; sarcopenia