title: Cytokine Responses to Acute Intermittent Aerobic Exercise in Children With Prader-Willi Syndrome and Nonsyndromic Obesity.
abstract: Prader-Willi Syndrome (PWS), the best characterized form of syndromic obesity, presents with abnormally high fat mass. In children, obesity presents with low-grade systemic inflammation. This study evaluated if PWS and/or nonsyndromic obesity affected cytokine responses to intermittent aerobic exercise in children. Eleven children with PWS (11 ± 2 y, 45.4 ± 9.5% body fat), 12 children with obesity (OB) (9 ± 1 y, 39.9 ± 6.8% body fat), and 12 lean (LN) children (9 ± 1 y, 17.5 ± 4.6% body fat) participated. Children completed 10 2-min cycling bouts of vigorous intensity, separated by 1-min rest. Blood samples were collected preexercise (PRE), immediately postexercise (IP), and 15, 30, and 60 min into recovery to analyze possible changes in cytokines. In all groups, IL-6 and IL-8 concentrations were greater during recovery compared with PRE. PWS and OB exhibited higher IL-6 area under the curve (AUC) than LN (p < .01 for both). PWS demonstrated higher IL-8 AUC than LN (p < .04). IL-10, TNF-α, and IFN-γ did not change with exercise (p > .05 for all). Results indicate that children with PWS respond with increased Il-6 and IL-8 concentrations to acute exercise similarly to controls. Excess adiposity and epigenetic modifications may explain the greater integrated IL-6 and IL-8 responses in PWS compared with controls.
authors.affiliation: Dept. of Kinesiology, California State University Fullerton, Fullerton, CA.
authors.forename: Andrea T
authors.initials: AT
authors.lastname: Duran
authors.forename: Erik
authors.initials: E
authors.lastname: Gertz
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Judelson
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Haqq
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Clark
authors.forename: Kavin W
authors.initials: KW
authors.lastname: Tsang
authors.forename: Daniela
authors.initials: D
authors.lastname: Rubin
mesh_terms: D050154:Adiposity; D000293:Adolescent; D019540:Area Under Curve; D002648:Child; D016207:Cytokines / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D063766:Pediatric Obesity / Q000097:blood; D005082:Physical Exertion / Q000502:physiology; D011218:Prader-Willi Syndrome / Q000097:blood*; D013851:Thinness / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma