title: Selenocystine-induced cell apoptosis and S-phase arrest inhibit human triple-negative breast cancer cell proliferation.
abstract: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited effective treatment options. New therapeutic approaches are urgently needed to improve the prognosis of TNBC. Here we demonstrated that a redox modulator, selenocystine (SeC), significantly inhibits TNBC cell proliferation in a dose- and time-dependent manner. Through cell apoptosis assays and cell cycle distribution analyses, we have shown that the in vitro inhibitory effect of SeC on TNBC cells can be attributed to the induction of apoptosis and the S-phase arrest in a dose-dependent manner. Therefore, this finding implies that SeC potentially is a novel therapeutic agent for TNBC.
authors.affiliation: Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China.
authors.forename: Meijun
authors.initials: M
authors.lastname: Long
authors.affiliation: Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China.
authors.forename: Juekun
authors.initials: J
authors.lastname: Wu
authors.affiliation: Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China.|Department of Gland Surgery, Guangzhou Panyu Central Hospital, 8 Fuyudong Road, Qiaonan Street, Guangzhou, Guangdong, 511400, China.
authors.forename: Junwen
authors.initials: J
authors.lastname: Hao
authors.affiliation: Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China.|Department of Breast Surgery, Guangzhou Red Cross Hospital, 396 Tongfuzhong Road, Guangzhou, Guangdong, 510220, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China.|Department of General Surgery, Changsha Central Hospital, 161 Shaoshannan Road, Changsha, Hunan, 410004, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX, 78229, USA.
authors.forename: Hang
authors.initials: H
authors.lastname: Su
authors.affiliation: Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China. wsqiu-d@163.com.
authors.forename: Wanshou
authors.initials: W
authors.lastname: Qiu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003553:Cystine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016566:Organoselenium Compounds / Q000494:pharmacology*; D059807:S Phase Cell Cycle Checkpoints / Q000187:drug effects*; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D016566:Organoselenium Compounds; C009226:selenocystine; D003553:Cystine
keywords: Apoptosis; Proliferation; S-phase arrest; Selenocystine; Triple-negative breast cancer