title: Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study.
abstract: Decompressive craniectomy (DC) is one of the therapeutic options for severe traumatic brain injury (TBI), and it has long been used for the treatment of patients with malignant post-traumatic brain edema. However, a lack of definitive evidence prevents physicians from drawing any conclusions about the efficacy of DC for the treatment of TBI. Magnetic resonance imaging (MRI) is widely used to evaluate the effects of TBI in both experimental and clinical studies. Therefore, the aim of the present study was to investigate the MRI assessment of DC post-TBI in rats to provide experimental animal data and radiological evidence to support the clinical application of DC. We used both in vivo MRI and proton magnetic resonance spectroscopy ((1)H-MRS) to evaluate the therapeutic effect of DC on lateral controlled cortical impact (CCI) rat models at 3h, 1 d, 2 d, 3d and 7d after TBI. Our data suggest that DC can reduce brain edema; decrease the apparent diffusion coefficient value, contusion volume and lactate (Lac)/creatine (Cr) ratio; and increase the N-acetylaspartate (NAA)/Cr and choline (Cho)/Cr ratios after TBI. The present results suggest that DC can indeed reduce brain edema formation and exhibits good neuroprotective efficacy after CCI injury in rats.
authors.affiliation: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, PR China; Beijing Key Laboratory of Central Nervous System Injury, Beijing 100050, PR China.
authors.forename: Runfa
authors.initials: R
authors.lastname: Tian
authors.affiliation: Department of Neurology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, PR China; Beijing Key Laboratory of Central Nervous System Injury, Beijing 100050, PR China. Electronic address: houzg2006@163.com.
authors.forename: Zonggang
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, PR China; Beijing Key Laboratory of Central Nervous System Injury, Beijing 100050, PR China.
authors.forename: Shuyu
authors.initials: S
authors.lastname: Hao
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230000, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of Neurotrauma, General Hospital of Armed Police Forces, Beijing 100039, PR China.
authors.forename: Zhendan
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, PR China; Beijing Key Laboratory of Central Nervous System Injury, Beijing 100050, PR China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Tao
authors.affiliation: Department of Neurology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, PR China; Neurotrauma Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, PR China; Department of Neurotrauma, General Hospital of Armed Police Forces, Beijing 100039, PR China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, PR China; Beijing Key Laboratory of Central Nervous System Injury, Beijing 100050, PR China. Electronic address: liubaiyun1212@163.com.
authors.forename: Baiyun
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001929:Brain Edema / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D056424:Decompressive Craniectomy; D004195:Disease Models, Animal; D019344:Lactic Acid / Q000378:metabolism; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D066244:Proton Magnetic Resonance Spectroscopy; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
chemical_list: D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline
keywords: Brain trauma; Controlled cortical impact; Decompressive craniectomy; Magnetic resonance imaging; Proton magnetic resonance spectroscopy