title: Radiation quality and ion-beam therapy: understanding the users' needs.
abstract: Ion-beam therapy faces a growing demand of tools able to map radiation quality within the irradiated volume. Although analytical computations and simulations provide useful estimations of dose and radiation quality, the direct measure of those parameters would improve ion-beam therapy in particular when deep-seated tumours are irradiated, tissue composition and density are variable or organs at risk are near the tumour. Several ion-beam therapy facilities are studying detectors and procedures for measuring the radiation quality on a microdosimetric as well as a nanodosimetric scale. Simplicity and miniaturisation of the devices are essential for measurements first in phantoms and thereafter during therapy, particularly for intra-cavity detectors. MedAustron is studying solid-state detectors based on a single crystal chemical vapour deposition diamond. In collaboration with Italian National Institute for Nuclear Physics (INFN), Tor Vergata and Legnaro; INFN-microdosimetry and track structure project; Austrian Institute of Technology, Vienna; and Italian National agency for new technologies, energy and sustainable economic development, Rome, prototypes have been developed to characterise radiation quality in sizes equivalent to one micrometre of biological tissue.
authors.affiliation: EBG MedAustron GmbH, Marie Curie-Straße 5, Wiener Neustadt A-2700, Austria giulio.magrin@medaustron.at.
authors.forename: G
authors.initials: G
authors.lastname: Magrin
authors.affiliation: EBG MedAustron GmbH, Marie Curie-Straße 5, Wiener Neustadt A-2700, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Mayer
authors.affiliation: INFN Tor Vervata University, via del Politecnico 1, 00133 Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Verona
authors.affiliation: EBG MedAustron GmbH, Marie Curie-Straße 5, Wiener Neustadt A-2700, Austria.
authors.forename: Loïc
authors.initials: L
authors.lastname: Grevillot
mesh_terms: D018130:Diamond / Q000737:chemistry*; D063193:Heavy Ion Radiotherapy / Q000592:standards*; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D011786:Quality Control; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D012062:Relative Biological Effectiveness
chemical_list: D018130:Diamond