title: A Clinical Investigation of Oral Sarcomas at Multi-institutions Over the Past 30 Years.
abstract: OBJECTIVE
  Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma.
  
  
  METHODS
  The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of oral and maxillofacial surgery at multi-institutions who had a histopathological diagnosis of malignant oral tumors.
  
  
  RESULTS
  Sarcoma accounted for 19 of 1,643 cases (1.16%) in malignant oral tumors. Histologically, osteosarcoma was most common in 6 of the 19 patients, followed by 3 cases each of leiomyosarcoma and malignant fibrous histiocytoma, 2 of rhabdomyosarcoma and 1 each of angiosarcoma, Ewing's sarcoma, malignant schwannoma, malignant rhabdoid tumor and undifferentiated sarcoma. Irrespective of the histological type, tumor diameter on initial examination was >50 mm in 8 patients, 7 of whom died. Tumor diameter was <50 mm in 11 patients, 6 of whom survived. Distant metastasis was present in 11 patients, 10 of whom died. The local control rate was 42.1% and 5-year survival rate was 36.8%.
  
  
  CONCLUSIONS
  Treatment of patients with tumors over 50-mm long in diameter and distant metastasis is extremely difficult. The incidence of oral sarcoma is very low. However, tumor diameter and presence of distant metastasis are important prognostic factors for oral sarcoma according to this multi-institutional study.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime, Japan tomoki@dent.kyushu-u.ac.jp.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Sumida
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan.
authors.forename: Naruto
authors.initials: N
authors.lastname: Otawa
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan.
authors.forename: Y U
authors.initials: YU
authors.lastname: Kamata
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan Department of Oral and Maxillofacial Surgery, Kochi University School of Medicine, Kochi, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yamada
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Uchida
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakano
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hamakawa
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kochi University School of Medicine, Kochi, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Ueyama
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology*; D011379:Prognosis; D012509:Sarcoma / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology*; D016019:Survival Analysis
keywords: Sarcoma; multi-institution study; oral cavity; prognostic factors