title: Chronic Inflammation-Related HPV: A Driving Force Speeds Oropharyngeal Carcinogenesis.
abstract: Oropharyngeal squamous cell carcinoma (OPSCC) has been known to be a highly aggressive disease associated with human papilloma virus (HPV) infection. To investigate the relationship between HPV and chronic inflammation in oropharyngeal carcinogenesis, we collected 140 oral mucous fresh specimens including 50 OPSCC patients, 50 cancer in situ, 30 precancerous lesions, and 10 normal oral mucous. Our data demonstrated that there was a significantly higher proportion of severe chronic inflammation in dysplastic epithelia in comparison with that in normal tissues (P<0.001). The positive rate of HPV 16 was parallel with the chronic inflammation degrees from mild to severe inflammation (P<0.05). The positive rate of HPV 16 was progressively improved with the malignant progression of oral mucous (P<0.05). In addition, CD11b+ LIN- HLA-DR-CD33+ MDSCs were a critical cell population that mediates inflammation response and immune suppression in HPV-positive OPSCC. These indicated that persistent chronic inflammation-related HPV infection might drive oropharyngeal carcinogenesis and MDSCs might pay an important role during this process. Thus, a combination of HPV infection and inflammation expression might become a helpful biomedical marker to predict oropharyngeal carcinogenesis.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Xiangrui
authors.initials: X
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Zhengge
authors.initials: Z
authors.lastname: Lei
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Cen
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Shiyu
authors.initials: S
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Qianming
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, China.
authors.forename: Yajie
authors.initials: Y
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China; Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Liang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000235:genetics / Q000821:virology; D002908:Chronic Disease; D018450:Disease Progression; D015870:Gene Expression; D054884:Host-Pathogen Interactions; D052162:Human papillomavirus 16 / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000235:genetics / Q000821:virology; D018836:Inflammation Mediators / Q000378:metabolism; D007371:Interferon-gamma / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D018664:Interleukin-12 / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D009959:Oropharyngeal Neoplasms / Q000150:complications* / Q000235:genetics / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications* / Q000235:genetics / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: D018836:Inflammation Mediators; D007376:Interleukin-2; D016753:Interleukin-10; D018664:Interleukin-12; D007371:Interferon-gamma