title: Total Synthesis of Amphirionin-4.
abstract: The first total synthesis of amphirionin-4 has been achieved using a combination of cross-coupling strategies to access the polyene side chain and a chlorohydrin-based approach to construct the tetrahydrofuranol core. The remote C9-stereocenter was introduced through a Nozaki-Hiyama-Kishi coupling that proceeded with remote stereoinduction.
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Holmes
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Kwon
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Matthew
authors.initials: M
authors.lastname: Taron
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Britton
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D004141:Dinoflagellida / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry*; D061065:Polyketides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D011090:Polyenes; D061065:Polyketides; C000599333:amphirionin-4