title: Comparison of Macular Thickness in Patients with Keratoconus and Control Subjects Using the Cirrus HD-OCT.
abstract: OBJECTIVE
  The aim of the present study was to compare macular thickness in patients with keratoconus (KC) with macular thickness in healthy subjects.
  
  
  METHODS
  Twenty-six patients with KC and 52 control subjects were included. The macular structure was evaluated using a Zeiss Cirrus HD-OCT. The scan pattern used was 512 × 128, which covers an area of approximately 6 × 6 mm of the retina. The cube volume was assessed as well as macular thickness in each of the 9 sectors defined by the software.
  
  
  RESULTS
  The mean signal strength was significantly lower in the KC group (mean 8.4, range 6-10) compared with the control group (mean 9.7, range 7-10), P < 0.0001 (unpaired t-test). There were no significant differences in cube volume (unpaired t-test), cube average thickness, or macular thickness between the KC group and the control subjects in any of the retinal locations (one-way ANOVA).
  
  
  CONCLUSIONS
  Macular structure as measured by OCT in KC subjects should be expected to lie within the range of age and sex matched controls.
authors.affiliation: Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, P.O. Box 8056, 10420 Stockholm, Sweden.
authors.forename: R L
authors.initials: RL
authors.lastname: Brautaset
authors.affiliation: Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, P.O. Box 8056, 10420 Stockholm, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Rosén
authors.affiliation: Optics Department, University of Valencia, C/Dr. Moliner 50, 46100 Burjassot, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Cerviño
authors.affiliation: TERTC, University of Houston, College of Optometry, Houston, TX 77204-2020, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Miller
authors.affiliation: TERTC, University of Houston, College of Optometry, Houston, TX 77204-2020, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bergmanson
authors.affiliation: Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, P.O. Box 8056, 10420 Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Nilsson
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000453:epidemiology / Q000473:pathology*; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000379:methods*