title: Papillary thyroid carcinoma with anaplastic dedifferentiation in the lymph node metastasis - a rare form of presentation even for a tall cell variant.
abstract: Papillary thyroid carcinoma (PTC) is well known as a differentiated thyroid carcinoma with an established treatment protocol and high survival rates. Nevertheless, its tall cell variant (TCV) is more frequent diagnosed with larger tumor size, advanced age and metastasis comparing to other PTC cases, resembling an increased level of aggressiveness attributable to the histological subtype according to recent studies. We present the case of a 60-year-old woman who came for a recently increase of the thyroid and a left laterocervical mass associated with pain and alteration of general status. Thyroidectomy revealed a TCV of PTC with infiltration of the extrathyroid tissue. The laterocervical mass posed difficulties to surgical excision but in a second attempt proved to be an undifferentiated carcinoma. The findings were associated to a rapid deterioration of the patient's general condition finalized with death within less than three months from the initial presentation.
authors.affiliation: Department of Endocrinology, "Carol Davila" University of Medicine and Pharmacy, "Elias" Hospital, Bucharest, Romania; carmen_gabriela_barbu@yahoo.co.uk.
authors.forename: Carmen Gabriela
authors.initials: CG
authors.lastname: Barbu
authors.forename: Andrei
authors.initials: A
authors.lastname: Florin
authors.forename: Marius Cristian
authors.initials: MC
authors.lastname: Neamţu
authors.forename: Elena Taina
authors.initials: ET
authors.lastname: Avramescu
authors.forename: Dana
authors.initials: D
authors.lastname: Terzea
authors.forename: Adrian
authors.initials: A
authors.lastname: Miron
authors.forename: Rucsandra
authors.initials: R
authors.lastname: Dănciulescu Miulescu
authors.forename: Cătălina
authors.initials: C
authors.lastname: Poiană
authors.forename: Simona
authors.initials: S
authors.lastname: Fica
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000473:pathology*; D002291:Carcinoma, Papillary; D054337:Cell Dedifferentiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D000077273:Thyroid Cancer, Papillary; D065646:Thyroid Carcinoma, Anaplastic / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology*