title: Efficient Palladium-Catalyzed C-H Fluorination of C(sp3)-H Bonds: Synthesis of β-Fluorinated Carboxylic Acids.
abstract: A novel and facile process for direct fluorination of unactivated C(sp3)-H bonds at the β position of carboxylic acids was accomplished by a palladium(II)-catalyzed C-H activation. The addition of Ag2O and pivalic acid was found to be crucial for the success of this transformation. This reaction provides a versatile strategy for the synthesis of β-fluorinated carboxylic acids.
authors.affiliation: †State Key Laboratory of Natural Medicines and ‡Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Qihua
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: †State Key Laboratory of Natural Medicines and ‡Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Ji
authors.affiliation: †State Key Laboratory of Natural Medicines and ‡Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Liang
authors.affiliation: †State Key Laboratory of Natural Medicines and ‡Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: †State Key Laboratory of Natural Medicines and ‡Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Yungen
authors.initials: Y
authors.lastname: Xu