title: [Association between genetic polymorphisms of EDNRA gene and high altitude polycythemia in Tibetans at the Qinghai-Tibetan Plateau].
abstract: OBJECTIVE
  To test the hypothesis that the polymorphisms in EDNRA gene are associated with the susceptibility to high-altitude polycythemia (HAPC) in Tibetans at the Qinghai-Tibetan Plateau in China.
  
  
  METHODS
  We enrolled 63 Tibetan HAPC patients and 131 healthy, age-and gender-matched control Tibetans. All subjects came from Yushu area of Qinghai where the altitude was over 3,500 meters. Five SNPs of EDNRA gene (rs10003447, rs1801708, rs2048894, rs5335 and rs6841581) were genotyped by the Sequenom MassARRAY SNP assays.
  
  
  RESULTS
  None of five SNPs in EDNRA gene were associated with HAPC risk (P=0.742; P=0.733; P=0.828; P=0.417; P=0.096).
  
  
  CONCLUSIONS
  EDNRA gene is likely to have adaptive benefits for high altitude environment. However, it is not protective against HAPC in Tibetans.
authors.affiliation: Research Center for High Altitude Medical Sciences, Qinghai University School of Medicine, Department of Clinical Medicine, Qinghai University School of Medicine, Xining 810001, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.forename: Yingzhong
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhan
authors.initials: Z
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Tang
authors.forename: Qin
authors.initials: Q
authors.lastname: Ga
authors.affiliation: Email: geriligao@hotmail.com.
authors.forename: Rili
authors.initials: R
authors.lastname: Ge
mesh_terms: D000532:Altitude Sickness; D002681:China; D005838:Genotype; D006801:Humans; D011086:Polycythemia; D020641:Polymorphism, Single Nucleotide; D018609:Tibet