title: Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  There is a need for a simple and accurate method for the assessment of cardiovascular risk in polycystic ovary syndrome (PCOS). Lipid accumulation product (LAP) is based on the assessment of waist circumference and serum triglycerides that yield an estimation of lipid overaccumulation. We aimed to determine whether LAP is associated with metabolic syndrome (MetS) in Caucasian women with PCOS.
  
  
  METHODS
  We studied 222 women with PCOS who were diagnosed using the Rotterdam criteria. In all the subjects and controls, LAP was determined and the MetS was assessed using three different international criteria, NCEP-ATP III, IDF, and JIS. ROC curve and logistic regression analyses were performed to determine and analyze associations with the MetS.
  
  
  RESULTS
  In the study population the prevalence of MetS was 16.2-19.4%. The cut-off value of 25.9 determined that LAP has the strongest association with MetS whichever international criteria are used, followed by HDL (NCEP-ATP III and JIS) and glucose (IDF).
  
  
  CONCLUSIONS
  LAP is used as an independent clinical indicator for MetS in our PCOS women of Caucasian origin. The high diagnostic accuracy of LAP is superseding the need for the use of multiple clinical indicators for the assessment of lipid accumulation as a prerequisite for diagnosis of metabolic and cardiovascular diseases in PCOS women.
authors.affiliation: Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Djuro
authors.initials: D
authors.lastname: Macut
authors.affiliation: Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Božić Antić
authors.affiliation: CHC Bežanijska kosa, Belgrade, Serbia.
authors.forename: Jelica
authors.initials: J
authors.lastname: Bjekić-Macut
authors.affiliation: Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Panidis
authors.affiliation: First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tziomalos
authors.affiliation: Department of Biochemistry, Institute for Biological Research "Siniša Stanković", Belgrade, Serbia.
authors.forename: Danijela
authors.initials: D
authors.lastname: Vojnović Milutinović
authors.affiliation: Institute of Medical Physiology, Faculty of Medicine, Belgrade, Serbia.
authors.forename: Olivera
authors.initials: O
authors.lastname: Stanojlović
authors.affiliation: Clinic for Obstetrics and Gynecology, Faculty of Medicine, Belgrade, Serbia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Kastratović-Kotlica
authors.affiliation: Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Petakov
authors.affiliation: Institute of Medical Statistics, Faculty of Medicine; University of Belgrade, Belgrade, Serbia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Milić
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D016015:Logistic Models; D024821:Metabolic Syndrome / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D055815:Young Adult