title: [Study on Content Determination of Lead and Arsenic in Four Traditional Tibetan Medicine Prescription Preparations by Wet Digestion Flow Injection-Hydride Generation-Atomic Absorption Spectrometry].
abstract: Four common traditional tibetan medicine prescription preparations "Anzhijinghuasan, Dangzuo, Renqingchangjue and Rannasangpei" in tibetan areas were selected as study objects in the present study. The purpose was to try to establish a kind of wet digestion and flow injection-hydride generation-atomic absorption spectrometry (FI-HAAS) associated analysis method for the content determinations of lead and arsenic in traditional tibetan medicine under optimized digestion and measurement conditions and determine their contents accurately. Under these optimum operating conditions, experimental results were as follows. The detection limits for lead and arsenic were 0.067 and 0.012 µg · mL(-1) respectively. The quantification limits for lead and arsenic were 0.22 and 0.041 µg · mL(-1) respectively. The linear ranges for lead and arsenic were 25-1,600 ng · mL(-1) (r = 0.9995) and 12.5-800 ng · mL(-1) (r = 0.9994) respectively. The degrees of precision(RSD) for lead and arsenic were 2.0% and 3.2% respectively. The recovery rates for lead and arsenic were 98.00%-99.98% and 96.67%-99.87% respectively. The content determination results of lead and arsenic in four traditional tibetan medicine prescription preparations were as fol- lows. The contents of lead and arsenic in Anzhijinghuasan are 0.63-0.67 µg · g(-1) and 0.32-0.33 µg · g(-1) in Anzhijinghua- san, 42.92-43.36 µg · g(-1) and 24.67-25.87 µg · g(-1) in Dangzuo, 1,611. 39-1,631.36 µg · g(-1) and 926.76-956.52 µg- g(-1) in Renqing Changjue, and 1,102.28-1,119.127 µg-g(-1) and 509.96-516.87 µg · g(-1) in Rannasangpei, respectively. This study established a method for content determination of lead and arsenic in traditional tibetan medicine, and determined the content levels of lead and arsenic in four tibetan medicine-prescription preparations accurately. In addition, these results also provide the basis for the safe and effective use of those medicines in clinic.
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Zheng
authors.forename: Yu-zhi
authors.initials: YZ
authors.lastname: Du
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Ming-jie
authors.initials: MJ
authors.lastname: Yu
authors.forename: Cen
authors.initials: C
authors.lastname: Li
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Zheng-hua
authors.initials: ZH
authors.lastname: Xia
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Wei
mesh_terms: D001151:Arsenic / Q000032:analysis*; D004340:Drug Contamination; D007854:Lead / Q000032:analysis*; D038861:Medicine, Tibetan Traditional; D013054:Spectrophotometry, Atomic
chemical_list: D007854:Lead; D001151:Arsenic