title: Regulation of cell differentiation and function by the euchromatin histone methyltranserfases G9a and GLP.
abstract: The euchromatin histone methyltransferases (EHMTs) are an evolutionarily conserved protein family that are known for their ability to dimethylate histone 3 at lysine 9 in euchromatic regions of the genome. In mammals there are two EHMT proteins, G9a, encoded by EHMT2, and GLP, encoded by EHMT1. EHMTs have diverse roles in the differentiation of different tissues and cell types and are involved in adult-specific processes like memory, drug addiction, and immune response. This review discusses recent findings from rodent and Drosophila models that are beginning to reveal the broad biological role and complex mechanistic functioning of EHMT proteins.
authors.affiliation: Department of Physiology and Pharmacology, Department of Biology, Western University, London, Ontario, Canada.|Department of Physiology and Pharmacology, Department of Biology, Western University, London, Ontario, Canada.
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Kramer
mesh_terms: D050156:Adipogenesis; D000818:Animals; D002454:Cell Differentiation; D004331:Drosophila melanogaster; D022041:Euchromatin / Q000201:enzymology*; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D007111:Immunity, Cellular; D008239:Lysine / Q000378:metabolism; D008568:Memory; D008745:Methylation; D051379:Mice; D018345:Mice, Knockout; D000066450:Mouse Embryonic Stem Cells / Q000502:physiology; D009473:Neuronal Plasticity; D051381:Rats; D019966:Substance-Related Disorders / Q000201:enzymology
chemical_list: D022041:Euchromatin; D006657:Histones; D011495:Histone-Lysine N-Methyltransferase; D008239:Lysine
keywords: EHMT; G9a; GLP; H3K9 methylation; epigenetics; méthylation de H3K9; épigénétique