title: [Hematological changes induced by erythrocytapheresis].
abstract: BACKGROUND
  Although automated cell separators (apheresis) have undergone a lot of technical refinements, the effect of the procedure on hematological indices of donors is rarely taken into account. The purpose of this study is to identify potential hematologic changes in donors undergoing erythrocytapheresis.
  
  
  METHODS
  30 apparently healthy adult donors were evaluated. Erythrocytapheresis procedure was performed using automated equipment. Hematologic measurements (hemoglobin, hematocrit, white blood cells counts and platelets) were analyzed before and after erythrocytapheresis in all donors.
  
  
  RESULTS
  We observed a significant decrease in the donors in hemoglobin (p <0.0001), hematocrit (p <0.0001), leukocytes (p <0.0001), lymphocytes (p = 0.0267), and platelets (p <0.0001). On the other hand, we found no changes in segmented, monocytes, eosinophils and basophils post erythrocytapheresis.
  
  
  CONCLUSIONS
  In this study we found a significant drop in complete blood count in blood donation procedure by erythrocytapheresis; there are hematological changes in both red and white cells in all donors; however, none of donors manifested symptoms of thrombocytopenia or anemia. This study demonstrates hematological changes post-donation and therefore requires larger multicenter studies, in order to establish guidelines for donors' safety in apheresis and also help in assessing donor suitability, especially given the present trend of double product apheresis collections.
authors.affiliation: Laboratorio de Patología Clínica, Centro Médico The American British Cowdray, Distrito Federal, México. jmgallardom@gmail.com.
authors.forename: Sindy Karina Ibeth
authors.initials: SK
authors.lastname: Domínguez-Morales
authors.forename: Luis Carlos
authors.initials: LC
authors.lastname: Moreno-López
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Gallardo
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Paniagua
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001781:Blood Component Removal / Q000009:adverse effects*; D001782:Blood Donors; D003430:Cross-Sectional Studies; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins
keywords: Blood banks; Blood component removal; Blood donors; Erythrocytes