title: Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice.
abstract: Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2 diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically modified by deglycosylation and esterification to obtained ziyuglycoside II methyl ester (ZG02-ME). Here, we showed that ZG02-ME has stronger anti-diabetic activity than the original compound (ZG01) through decreasing blood glucose, glycated hemoglobin (HbA1c), and insulin levels in a mouse model of type 2 diabetes (db/db mice). We further found that ZG02-ME treatment effectively ameliorated serum insulin, leptin and C-peptide levels, which are key metabolic hormones, in db/db mice. In addition, we showed that elevated basal blood lipid levels were decreased by ZG02-ME treatment in db/db mice. Furthermore, treatment of ZG02-ME significantly decreased serum AST, ALT, BUN, creatinine, and liver lipid peroxidation in db/db mice. These results demonstrated that compared to ZG01, chemically modified ZG02-ME possess improved anti-diabetic properties, and has hepato-renal protective activities in type 2 diabetes.
authors.affiliation: College of Pharmacy & Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-951, Korea. sondj1@hotmail.com.
authors.forename: Dong Ju
authors.initials: DJ
authors.lastname: Son
authors.affiliation: Department of Biomedical Laboratory Science, College of Natural Science, Daejeon University, Daejeon 300-716, Korea. syhwang@dju.kr.
authors.forename: Seock Yeon
authors.initials: SY
authors.lastname: Hwang
authors.affiliation: Department of Physiology, College of Korean Medicine, Daejeon University, Daejeon 300-716, Korea. abeliophylum@naver.com.
authors.forename: Myung-Hyun
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Department of Biomedical Laboratory Science, College of Natural Science, Daejeon University, Daejeon 300-716, Korea. saladin04@naver.com.
authors.forename: Un Kyu
authors.initials: UK
authors.lastname: Park
authors.affiliation: Department of Physiology, College of Korean Medicine, Daejeon University, Daejeon 300-716, Korea. kbsoo25@dju.kr.
authors.forename: Byoung Soo
authors.initials: BS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D015394:Molecular Structure; D031993:Sanguisorba / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D012503:Saponins; C000588918:ziyuglycoside II
keywords: Sanguisorba officinalis; diabetes; diabetic hepatopathy; diabetic nephropathy; ziyuglycoside