title: Local delivery of zoledronate from a poly (D,L-lactide)-Coating increases fixation of press-fit implants.
abstract: Early secure fixation of total joint replacements is crucial for long-term survival. Antiresorptive agents such as bisphosphonates have been shown to increase implant fixation. We investigated whether local delivery of zoledronate from poly-D, L-lactide (PDLLA)-coated implants could improve implant fixation and osseointegration. Experimental titanium implants were bilaterally inserted press-fit into the proximal tibiae of 10 dogs. On one side the implant was coated with PDLLA containing zoledronate. The contralateral implant was uncoated and used as control. Observation period was 12 weeks. Implant fixation was evaluated with histomorphometry and biomechanical push-out test. We found an approximately twofold increase in all biomechanical parameters when comparing data from the zoledronate group with their respective controls. Histomorphometry showed increased amount of preserved bone and increased bone formation around the zoledronate implants. This study indicates that local delivery of zoledronate from a PDDLA coating has the potential to increase implant fixation.
authors.affiliation: Department of Orthopaedics, Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Jakobsen
authors.affiliation: Orthopaedic Biomechanics Laboratory, Minneapolis Medical Research Foundation and University of Minnesota, Minneapolis, Minnesota.
authors.forename: Joan E
authors.initials: JE
authors.lastname: Bechtold
authors.affiliation: Department of Orthopaedics, Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Kjeld
authors.initials: K
authors.lastname: Søballe
authors.affiliation: Department of Orthopaedics, Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Jensen
authors.affiliation: Sporthopaedicum Regensburg, Regensburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Greiner
authors.affiliation: Department of Orthopaedics, Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Marianne T
authors.initials: MT
authors.lastname: Vestermark
authors.affiliation: Department of Orthopaedics, Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Jørgen
authors.initials: J
authors.lastname: Baas
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D004164:Diphosphonates / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage*; D016348:Osseointegration / Q000187:drug effects*; D011091:Polyesters; D019736:Prostheses and Implants; D011897:Random Allocation; D014025:Titanium; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D011091:Polyesters; C033616:poly(lactide); D000077211:Zoledronic Acid; D014025:Titanium
keywords: PDDLA; bisphosphonate; implant fixation