title: Beginning at the end: DNA replication within the telomere.
abstract: Using single molecule analysis of replicated DNA (SMARD), Drosopoulos et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410061) report that DNA replication initiates at measurable frequency within the telomere of mouse chromosome arm 14q. They demonstrate that resolution of G4 structures on the G-rich template strand of the telomere requires some overlapping functions of BLM and WRN helicase for leading strand synthesis.
authors.affiliation: Division of Biology and Medicine, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912 Susan_Gerbi@Brown.edu.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Gerbi
mesh_terms: D000818:Animals; D004261:DNA Replication; D053484:RecQ Helicases / Q000502:physiology*; D016615:Telomere / Q000502:physiology*
chemical_list: D053484:RecQ Helicases