title: Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland in a male patient: a case report and literature review.
abstract: Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) was first described by Chan et al in 1991. It is characterized by nest or strands of epidermoid tumor cells with squamous differentiation, rare mucous cells, prominent sclerotic stroma, eosinophilic and lymphoplasmacytic infiltration, and a background of chronic lymphocytic thyroiditis in the non-neoplastic thyroid gland. It is important to recognize SMECE of thyroid and differentiate it from squamous cell carcinoma or other neoplasms with squamous differentiation/metaplasia. In published cases, the SMECE of thyroid gland predominantly occurs in women. We report a case of SMECE of thyroid in a 45-year-old male patient. All cases in male patients were Caucasian described in English literature, and our case is the first one in Asian.
authors.affiliation: Department of Pathology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine Taoyuan, Taiwan ROC.
authors.forename: Chi-Yun
authors.initials: CY
authors.lastname: Lai
authors.affiliation: Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine Taoyuan, Taiwan ROC.
authors.forename: Tzu-Chieh
authors.initials: TC
authors.lastname: Chao
authors.affiliation: Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine Taoyuan, Taiwan ROC.
authors.forename: Jen-Der
authors.initials: JD
authors.lastname: Lin
authors.affiliation: Department of Pathology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine Taoyuan, Taiwan ROC.
authors.forename: Chuen
authors.initials: C
authors.lastname: Hsueh
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018277:Carcinoma, Mucoepidermoid / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000473:pathology* / Q000601:surgery; D050031:Hashimoto Disease / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011237:Predictive Value of Tests; D012598:Sclerosis; D013961:Thyroid Gland / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Hashimoto thyroiditis; Sclerosing mucoepidermoid carcinoma; eosinophilia; male; thyroid gland