title: Composition, antibacterial, antioxidant and antiproliferative activities of essential oils from three Origanum species growing wild in Lebanon and Greece.
abstract: The essential oils from Origanum dictamnus, Origanum libanoticum and Origanum microphyllum were analysed by GC-MS, finding carvacrol, p-cymene, linalool, γ-terpinene and terpinen-4-ol as major components. The antioxidant activity by the DPPH and FRAP tests and the antiproliferative activity against two human cancer cell lines, LoVo and HepG2, were investigated, showing that the essential oil of O. dictamnus was statistically the most inhibitory on both the cell lines, while all the oils exerted a weak antioxidant activity. Furthermore, the samples were tested against 10 Gram-negative and Gram-positive bacteria; all the oils were active on Gram-positive bacteria but O. dictamnus essential oil was the most effective (MIC = 25-50 μg/mL), showing also a good activity against the Gram-negative Escherichia coli (MIC = 50 μg/mL). Data suggest that these essential oils and particularly O. dictamnus oil could be used as valuable new flavours with functional properties for food or nutraceutical products.
authors.affiliation: a Department of Pharmacy , Health and Nutrition Sciences, University of Calabria , Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Marrelli
authors.affiliation: a Department of Pharmacy , Health and Nutrition Sciences, University of Calabria , Italy.
authors.forename: Filomena
authors.initials: F
authors.lastname: Conforti
authors.affiliation: b Department of Pharmacy , University of Naples ''Federico II" , via D. Montesano 49, 80131 Naples , Italy.
authors.forename: Carmen
authors.initials: C
authors.lastname: Formisano
authors.affiliation: b Department of Pharmacy , University of Naples ''Federico II" , via D. Montesano 49, 80131 Naples , Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Rigano
authors.affiliation: c Faculté des Sciences Agronomiques, Université Saint Esprit , Kaslik (Beyrouth) , Lebanon.
authors.forename: Nelly Apostolides
authors.initials: NA
authors.lastname: Arnold
authors.affiliation: a Department of Pharmacy , Health and Nutrition Sciences, University of Calabria , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
authors.affiliation: b Department of Pharmacy , University of Naples ''Federico II" , via D. Montesano 49, 80131 Naples , Italy.
authors.forename: Felice
authors.initials: F
authors.lastname: Senatore
mesh_terms: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D000081005:Cyclohexane Monoterpenes; D000081007:Cymenes; D004926:Escherichia coli / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006115:Greece; D006801:Humans; D007861:Lebanon; D039821:Monoterpenes / Q000302:isolation & purification / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry*; D031341:Origanum / Q000737:chemistry* / Q000145:classification; D010938:Plant Oils / Q000737:chemistry
chemical_list: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D000081005:Cyclohexane Monoterpenes; D000081007:Cymenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; C007210:4-cymene; C018669:gamma-terpinene; C073316:carvacrol; C018584:linalool
keywords: Origanum species; antibacterial; antioxidant; antiproliferative; essential oil