title: Neuroprotective effects of (E)-3,4-diacetoxystyryl sulfone and sulfoxide derivatives in vitro models of Parkinson's disease.
abstract: (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides have been reported as novel multifunctional neuroprotective agents in previous studies, which as phenolic compounds display antioxidative and antineuroinflammatory properties. To further enhance the neuroprotective effects and study structure-activity relationship of the derivatives, we synthesized their acetylated derivatives, (E)-3,4-diacetoxystyryl sulfones and sulfoxides, and examined their neuroprotective effects in vitro models of Parkinson's disease. The results indicate that (E)-3,4-diacetoxystyryl sulfones and sulfoxides can significantly inhibit kinds of neuron cell injury induced by toxicities, including 6-OHDA, NO, and H2O2. More important, they show higher antineuroinflammatory properties and similar antioxidative properties to corresponding un-acetylated compounds. Thus, we suggest that (E)-3,4-diacetoxystyryl sulfones and sulfoxides may have potential for the treatment of neurodegenerative disorders, especially Parkinson's disease.
authors.affiliation: a Department of Chemical Biology , School of Pharmaceutical Sciences, Peking University , Beijing , China and.
authors.forename: Xianling
authors.initials: X
authors.lastname: Ning
authors.affiliation: a Department of Chemical Biology , School of Pharmaceutical Sciences, Peking University , Beijing , China and.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Yuan
authors.affiliation: a Department of Chemical Biology , School of Pharmaceutical Sciences, Peking University , Beijing , China and.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.affiliation: a Department of Chemical Biology , School of Pharmaceutical Sciences, Peking University , Beijing , China and.
authors.forename: Chao
authors.initials: C
authors.lastname: Tian
authors.affiliation: a Department of Chemical Biology , School of Pharmaceutical Sciences, Peking University , Beijing , China and.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Department of Chemical Biology , School of Pharmaceutical Sciences, Peking University , Beijing , China and.
authors.forename: Zhili
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: a Department of Chemical Biology , School of Pharmaceutical Sciences, Peking University , Beijing , China and.|b State Key Laboratory of Natural and Biomimetic Drugs , Peking University , Beijing , China.
authors.forename: Junyi
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D016716:PC12 Cells; D010300:Parkinson Disease / Q000188:drug therapy* / Q000473:pathology*; D051381:Rats; D012451:Safrole / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C000611940:(E)-3,4-diacetoxystyryl sulfone; D000975:Antioxidants; D008070:Lipopolysaccharides; D018696:Neuroprotective Agents; D013343:Styrenes; D013450:Sulfones; D009569:Nitric Oxide; D012451:Safrole; C005746:sulfoxide
keywords: (E)-3; 4-diacetoxystyryl sulfones and sulfoxides; Acetylated derivatives; neuroprotective agents