title: 14 Days of supplementation with blueberry extract shows anti-atherogenic properties and improves oxidative parameters in hypercholesterolemic rats model.
abstract: The effects of supplementation with blueberry (BE) extract (Vaccinium ashei Reade) for 14 consecutive days on biochemical, hematological, histopathological and oxidative parameters in hypercholesterolemic rats were investigated. After supplementation with lyophilized extract of BE, the levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides were decreased. Histopathological analysis showed significant decrease (p < 0.05) of aortic lesions in hypercholesterolemic rats. Oxidative parameters showed significant reductions (p < 0.05) in oxidative damage to lipids and proteins and an increase in activities of antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase. The BE extract showed an important cardioprotective effect by the improvements in the serum lipid profile, antioxidant system, particularly in reducing oxidative stress associated with hypercholesterolemia and anti-atherogenic effect in rats.
authors.affiliation: Postgraduate Program in Biochemistry .
authors.forename: Deise Jaqueline
authors.initials: DJ
authors.lastname: Ströher
authors.forename: Jacqueline da Costa
authors.initials: Jda C
authors.lastname: Escobar Piccoli
authors.forename: Angélica Aparecida da Costa
authors.initials: AA
authors.lastname: Güllich
authors.forename: Bruna Cocco
authors.initials: BC
authors.lastname: Pilar
authors.forename: Ritiéle Pinto
authors.initials: RP
authors.lastname: Coelho
authors.forename: Jamila Benvegnú
authors.initials: JB
authors.lastname: Bruno
authors.forename: Debora
authors.initials: D
authors.lastname: Faoro
authors.forename: Vanusa
authors.initials: V
authors.lastname: Manfredini
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D050197:Atherosclerosis / Q000097:blood / Q000517:prevention & control*; D029798:Blueberry Plants; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D019587:Dietary Supplements; D005638:Fruit; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D050050:Protein Carbonylation / Q000187:drug effects; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
keywords: Functional foods; Vaccinium ashei Reade; lipids; oxidative stress