title: Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.
abstract: A general approach for the synthesis of carbonic anhydrases glycoinhibitors belonging to an aminoxysulfonamide series is presented using a Ferrier sulfonamidoglycosylation reaction on glycals. All the compounds showed good in vitro inhibitory activity against four human carbonic anhydrase isoforms, with selectivity against the cytosolic (hCA II) vs the tumor associated (hCA IX and XII) enzymes.
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS-ENSCM-Université de Montpellier, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier , 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France.
authors.forename: Joanna
authors.initials: J
authors.lastname: Ombouma
authors.affiliation: Laboratorio di Chimica Bioinorganica, Polo Scientifico, Università degli Studi di Firenze , 50134 Sesto Fiorentino, Florence, Italy.
authors.forename: Daniella
authors.initials: D
authors.lastname: Vullo
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS-ENSCM-Université de Montpellier, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier , 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
authors.affiliation: Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze , Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS-ENSCM-Université de Montpellier, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier , 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Winum
keywords: Ferrier rearrangement; Glycoinhibitor; aminoxysulfonamide; carbonic anhydrase; zinc binding function