title: The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population.
abstract: This study aimed to test the association between the European GWAS-identified risk IQGAP2 SNP rs457717 (A>G) and age-related hearing impairment (ARHI) in a Han male Chinese (HMC) population. A total of 2420 HMC subjects were divided into two groups [group 70+: >70 years (n = 1306), and group 70-: ≤70 years (n = 1114)]. The participants were categorised into case and control groups according to Z high scores for group 70- and the severity of hearing loss and different audiogram shapes identified by K-means cluster analysis for group 70+. The IQGAP2 tagSNP rs457717 was genotyped in accordance with the different ARHI phenotypes. The genotype distributions of IQGAP2 (AA/AG/GG) were not significantly different between the case and control groups (P = 0.613 for group 70-; P = 0.602 for group 70+). Compared with genotype AA, the ORs of genotypes AG and GG for ARHI were not significantly different following adjustment for other environmental risk factors. We demonstrated that the IQGAP2 TagSNP rs457717 (A/G) was not associated with ARHI in HMC individuals.
authors.affiliation: Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road Pudong New Area, Shanghai, 200127, People's Republic of China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Luo
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.|Ear Institute, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Renji-Med X Clinical Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Hailian
authors.initials: H
authors.lastname: Shen
authors.affiliation: Shanghai Center for Bioinformation Technology, Shanghai, 200235, People's Republic of China.|Department of Bioinformatics and Biostatistics, College of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, 200240, People's Republic of China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.|Ear Institute, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.|Ear Institute, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Zhiwu
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road Pudong New Area, Shanghai, 200127, People's Republic of China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.|Ear Institute, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Xiuhong
authors.initials: X
authors.lastname: Pang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.|Ear Institute, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Xianting
authors.initials: X
authors.lastname: Hu
authors.affiliation: Ear Institute, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.|Health Check-up Center, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Health Check-up Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Zhuping
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road Pudong New Area, Shanghai, 200127, People's Republic of China. drlijiping@163.com.
authors.forename: Jiping
authors.initials: J
authors.lastname: Li
mesh_terms: D000368:Aged; D001299:Audiometry / Q000379:methods; D002681:China / Q000453:epidemiology; D004777:Environment; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011304:Presbycusis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors; D020703:ras GTPase-Activating Proteins / Q000235:genetics*
chemical_list: C101002:IQGAP2 protein, human; D020703:ras GTPase-Activating Proteins
keywords: Age-related hearing impairment; Association study; Candidate gene; Genotype; IQ motif-containing GTPase activating-like protein; Phenotype