title: An fMRI Study of Local Synchronization in Different Subfrequency Bands during the Continuous Feedback of Finger Force.
abstract: Conventional functional magnetic resonance imaging (fMRI) studies on motor feedback employ periodical blocked paradigm which does not allow frequency analysis of brain activity. Here, we carried out an fMRI study by using a continuous paradigm, that is, continuous (8 min) feedback of finger force. Borrowing an analytic method widely used in resting-state fMRI studies, that is, regional homogeneity (ReHo), we compared the local synchronization in some subfrequency bands between real and sham feedback, and the subbands were defined as Slow-6 (0.0-0.01 Hz), Slow-5 (0.01-0.027 Hz), Slow-4 (0.027-0.073 Hz), Slow-3 (0.073-0.198 Hz), and Slow-2 (0.198-0.25 Hz). Our results revealed that the five subfrequency bands of brain activity contributed to the changes of ReHo between real and sham feedback differently, and, more importantly, the changes in basal ganglia were only manifested in Slow-6, implicating the fact that ReHo in ultraslow band may be associated with the functional significance of BG, that is, motor control. These findings provide novel insights into the neural substrate underlying motor feedback, and properties of the ultraslow band of local synchronization deserve more attention in future explorations.
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ; Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
authors.forename: Zhong-Zhan
authors.initials: ZZ
authors.lastname: Gao
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ; Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zang
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D058256:Brain Waves / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D053580:Muscle Strength / Q000502:physiology*; D011859:Radiography