title: In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method.
abstract: Microvascular network of the retina plays an important role in diagnosis and monitoring of various retinal diseases. We propose a three-dimensional (3-D) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source optical coherence tomography. The automatic 3-D segmentation method is used to obtain seven surfaces of intraretinal layers. The microvascular network of the retina, which is acquired by the IBDV method, can be divided into six layers. The microvascular network of the six individual layers is visualized, and the morphology and contrast images can be improved by using the segmentation method. This method has potential for earlier diagnosis and precise monitoring in retinal vascular diseases.
authors.affiliation: Wenzhou Medical University, School of Optometry and Ophthalmology, 270 Xueyuan Road, Wenzhou 325027, ChinabUniversity of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United States.
authors.forename: Shenghai
authors.initials: S
authors.lastname: Huang
authors.affiliation: University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United States.
authors.forename: Zhonglie
authors.initials: Z
authors.lastname: Piao
authors.affiliation: University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United States.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Wenzhou Medical University, School of Optometry and Ophthalmology, 270 Xueyuan Road, Wenzhou 325027, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Lu
authors.affiliation: Wenzhou Medical University, School of Optometry and Ophthalmology, 270 Xueyuan Road, Wenzhou 325027, ChinabUniversity of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United StatescUniversity of Cal.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D005240:Feasibility Studies; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D055806:Microvessels / Q000033:anatomy & histology; D012171:Retinal Vessels / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000379:methods*