title: Synthesis, Structure and Antioxidant Activity of Cyclohexene-Fused Selenuranes and Related Derivatives.
abstract: Synthesis, structure and antioxidant activity of new cyclohexene-fused spiroselenuranes and a spirotellurane is reported. Oxidation reactions of bis(o-formylcyclohex- 1-ene)selenide/bis(2-hydroxymethylcyclohex-1-ene)selenide provide the corresponding spiroselenuranes. The glutathione peroxidase-like activity of the newly synthesized compounds has been evaluated.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India. poonam@chem.iitb.ac.in.
authors.forename: Poonam Rajesh
authors.initials: PR
authors.lastname: Prasad
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India. chhbsia@chem.iitb.ac.in.
authors.forename: Harkesh B
authors.initials: HB
authors.lastname: Singh
authors.affiliation: Department of Chemistry, Howard University, Washington, DC 20059, USA. rbutcher99@yahoo.com.
authors.forename: Ray J
authors.initials: RJ
authors.lastname: Butcher
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis*; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D053138:Cyclohexenes / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000737:chemistry; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013691:Tellurium / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D000975:Antioxidants; D053138:Cyclohexenes; D016566:Organoselenium Compounds; D013141:Spiro Compounds; C052568:cyclohexene; D005979:Glutathione Peroxidase; D013691:Tellurium
keywords: Se–O linkage; antioxidant; glutathione peroxidase (GPx); monochalcogenides; spirodioxychalcogenuranes