title: How the pharmacokinetics and receptor-binding profile of lurasidone affect the clinical utility and safety of the drug in the treatment of schizophrenia.
abstract: BACKGROUND
  This paper reviews the pharmacokinetic and safety profile of lurasidone from the perspective of clinical pharmacology and helps the clinician compare this drug with others from the same therapeutic class to aid in drug selection and use in specific situations.
  
  
  METHODS
  We reviewed the literature using the keywords 'lurasidone,' 'schizophrenia' and 'clinical trials.' In our review, particular attention was paid to those articles that reviewed the pharmacokinetic characteristics of the drug and its efficacy and safety/tolerability based on data from registration trials.
  
  
  CONCLUSIONS
  Lurasidone may be more effective and/or better tolerated than other antipsychotics by some patients although there is currently no way to identify which patients will best respond to which antipsychotic medication. Data from clinical trials of lurasidone in schizophrenia suggest a lower likelihood of weight gain and metabolic problems in patients being treated with lurasidone versus olanzapine and quetiapine.
authors.affiliation: University of Kansas School of Medicine-Wichita, Psychiatry and Behavioral Sciences , 1010 N Kansas, KS, 67214 US mmacaluso@kumc.edu.
authors.forename: Matthew
authors.initials: M
authors.lastname: Macaluso
authors.forename: Hala
authors.initials: H
authors.lastname: Kazanchi
authors.forename: Sheldon H
authors.initials: SH
authors.lastname: Preskorn
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D006801:Humans; D000069056:Lurasidone Hydrochloride / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D008659:Metabolic Diseases / Q000139:chemically induced / Q000453:epidemiology; D012559:Schizophrenia / Q000188:drug therapy*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D000069056:Lurasidone Hydrochloride
keywords: atypical antipsychotic; lurasidone; receptor binding affinity; schizophrenia