title: Treatment of central precocious puberty and early puberty with GnRH analog in girls with Williams-Beuren syndrome.
abstract: OBJECTIVE
  Little has been published on treatment of precocious puberty in girls with Williams-Beuren syndrome (WBS), a condition occurring frequently in this group. We analyzed our own data on growth/age at menarche of now adult female patients with WBS being diagnosed with central precocious puberty or early puberty. Data of patients treated with gonadotropin-releasing hormone (GnRH) analog (n=13) were compared with those not treated (control group, n=11).
  
  
  METHODS
  Longitudinal data on the somatic development of 24 now adult female patients were analyzed.
  
  
  RESULTS
  Medium final height was 157.2±6.5 cm compared to 151.4±5.6 cm in the control group. No significant difference could be found in the discrepancy of genetic target height and final height. Prepubertally girls were normal weight in both groups; in adulthood the majority of patients were overweight/obese. Menarche commenced 11 months after cessation of therapy.
  
  
  CONCLUSIONS
  As already known from other studies, hormonal suppression via GnRH analog was well tolerated.
authors.forename: Sarah
authors.initials: S
authors.lastname: Spielmann
authors.forename: Carl Joachim
authors.initials: CJ
authors.lastname: Partsch
authors.forename: Angela
authors.initials: A
authors.lastname: Gosch
authors.forename: Rainer
authors.initials: R
authors.lastname: Pankau
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use*; D011629:Puberty, Precocious / Q000188:drug therapy*; D016896:Treatment Outcome; D018980:Williams Syndrome / Q000188:drug therapy*
chemical_list: D005300:Fertility Agents, Female; D016729:Leuprolide