title: Two Cases of Thymic Carcinoma Initially Presenting as Bone Metastasis: A Clinical Report and the Usefulness of CD5 Immunohistochemistry for Assessing Bone Lesions.
abstract: Thymic carcinoma frequently spreads to the pleural space, regional lymph nodes, liver and lungs. However, an initial clinical presentation involving spinal or multiple bone metastases in patients with thymic carcinoma is extremely rare. We experienced two cases of thymic carcinoma that initially presented with spinal compression and severe pain due to multiple bone metastases, respectively. Both patients were histologically diagnosed with metastatic thymic squamous cell carcinoma based on the findings of specimens resected from the metastatic bone lesions. We herein describe the clinical courses of these cases and review the characteristics of bone metastasis of thymic carcinoma.
authors.affiliation: Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sasaki
authors.forename: Toshirou
authors.initials: T
authors.lastname: Fukushima
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Gomi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Nodoka
authors.initials: N
authors.lastname: Sekiguchi
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kitano
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001416:Back Pain / Q000209:etiology*; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D018956:CD5 Antigens / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013945:Thymoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D013953:Thymus Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D018956:CD5 Antigens