title: BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images.
abstract: Understanding the structure of single neurons is critical for understanding how they function within neural circuits. BigNeuron is a new community effort that combines modern bioimaging informatics, recent leaps in labeling and microscopy, and the widely recognized need for openness and standardization to provide a community resource for automated reconstruction of dendritic and axonal morphology of single neurons.
authors.affiliation: Allen Institute for Brain Science, Seattle, WA 98103, USA. Electronic address: hanchuanp@alleninstitute.org.
authors.forename: Hanchuan
authors.initials: H
authors.lastname: Peng
authors.affiliation: Allen Institute for Brain Science, Seattle, WA 98103, USA. Electronic address: mikeh@alleninstitute.org.
authors.forename: Michael
authors.initials: M
authors.lastname: Hawrylycz
authors.affiliation: Allen Institute for Brain Science, Seattle, WA 98103, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: Roskams
authors.affiliation: Center for Brain Simulation, Campus Biotech, Chemin des Mines, 9, 1202 Geneva, Switzerland.
authors.forename: Sean
authors.initials: S
authors.lastname: Hill
authors.affiliation: Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
authors.forename: Nelson
authors.initials: N
authors.lastname: Spruston
authors.affiliation: Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, the Netherlands.
authors.forename: Erik
authors.initials: E
authors.lastname: Meijering
authors.affiliation: Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA. Electronic address: ascoli@gmu.edu.
authors.forename: Giorgio A
authors.initials: GA
authors.lastname: Ascoli
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008853:Microscopy / Q000379:methods*; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology*; D061848:Optical Imaging