title: Carbon-14 urea breath test: does it work in patients with partial gastric resection?
abstract: OBJECTIVE
  The diagnostic value of Carbon-14 urea breath test (C-14 UBT) in the detection of Helicobacter pylori (H. pylori) infection in non-operated patients has been proved. However, the efficacy of C-14 UBT in patients with partial gastric resection (PGR) has not been evaluated yet. Herein, the results of the C-14 UBT and H. pylori stool antigen test (HpSAT) in this patient group were compared with the endoscopic findings.
  
  
  METHODS
  Multi-breath samples C-14 UBT and HpSAT were performed in all patients on the same day. Histology was used as a gold standard for testing C-14 UBT and HpSAT diagnostic efficacies.
  
  
  RESULTS
  30 patients (mean age: 54.6 ± 11 year) with PGR were included. The sensitivity and specificity of standard C-14 UBT were 29 and 100 %, respectively. When breath samples were collected at 20th min, and >35 CPM was selected as radioactivity threshold, the sensitivity raised to 86 % without any loss of specificity. The specificity and sensitivity of the HpSAT were 71 and 96 %, respectively.
  
  
  CONCLUSIONS
  The sensitivity of the standard C-14 UBT was very poor for patients with PGR, and results of HpSAT were superior in this population. Certain modifications are needed if C-14 UBT is to be used in PGR patients.
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey. fuatdede@yahoo.com.|Nukleer Tip Anabilim Dali, S.B. Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, -1 kat A1 Blok Fevzi Cakmak Mahallesi Mimar Sinan Caddesi No:41 Ustkaynarca, Pendik, Istanbul, Turkey. fuatdede@yahoo.com.
authors.forename: Fuat
authors.initials: F
authors.lastname: Dede
authors.affiliation: Nuclear Medicine Clinic, Kocaeli State Hospital, Kocaeli, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Civen
authors.affiliation: Department of Medical Oncology, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Faysal
authors.initials: F
authors.lastname: Dane
authors.affiliation: Internal Medicine Clinic, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aliustaoglu
authors.affiliation: Department of Medical Oncology, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Turhal
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Halil Turgut
authors.initials: HT
authors.lastname: Turoglu
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Sabahat
authors.initials: S
authors.lastname: Inanir
mesh_terms: D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000378:metabolism; D001944:Breath Tests / Q000379:methods*; D002250:Carbon Radioisotopes / Q000032:analysis*; D004945:Esophagoscopy / Q000379:methods; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005260:Female; D005743:Gastrectomy; D005773:Gastroscopy / Q000379:methods; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D016480:Helicobacter pylori / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013995:Time; D014508:Urea / Q000032:analysis*
chemical_list: D000942:Antigens, Bacterial; D002250:Carbon Radioisotopes; D014508:Urea
keywords: Carbon-14 urea breath test; Gastric cancer; Helicobacter pylori; Partial gastrectomy; Stool antigen test