title: In Vitro Studies of Chromone-Tetrazoles against Pathogenic Protozoa, Bacteria, and Fungi.
abstract: In vitro studies to fourteen previously synthesized chromone-tetrazoles and four novel fluorine-containing analogs were conducted against pathogenic protozoan (Entamoeba histolytica), pathogenic bacteria (Pseudomonas aeruginosa, and Staphylococcus aureus), and human fungal pathogens (Sporothrix schenckii, Candida albicans, and Candida tropicalis), which have become in a serious health problem, mainly in tropical countries.
authors.affiliation: Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. pedroacanom@gmail.com.
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Cano
authors.affiliation: Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. blackheim66@gmail.com.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Islas-Jácome
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. arangel@ugto.mx.
authors.forename: Ángeles
authors.initials: Á
authors.lastname: Rangel-Serrano
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. anayafe@ugto.mx.
authors.forename: Fernando
authors.initials: F
authors.lastname: Anaya-Velázquez
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. padillaf@ugto.mx.
authors.forename: Felipe
authors.initials: F
authors.lastname: Padilla-Vaca
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. elias_tru@hotmail.mx.
authors.forename: Elías
authors.initials: E
authors.lastname: Trujillo-Esquivel
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. poncep@ugto.mx.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ponce-Noyola
authors.affiliation: Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. richa@ugto.mx.
authors.forename: Antonio
authors.initials: A
authors.lastname: Martínez-Richa
authors.affiliation: Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. rociogm@ugto.mx.
authors.forename: Rocío
authors.initials: R
authors.lastname: Gámez-Montaño
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D041022:Candida tropicalis / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D002867:Chromones / Q000138:chemical synthesis / Q000494:pharmacology*; D004748:Entamoeba histolytica / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D005461:Fluorine / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D013175:Sporothrix / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D013777:Tetrazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D002867:Chromones; D013777:Tetrazoles; D005461:Fluorine
keywords: Ugi-azide reaction; antimicrobial activity; chromone-tetrazoles; pathogenic bacteria; pathogenic fungi; pathogenic protozoa; tropical diseases