title: Relation of platelet indices to severity of coronary artery disease in patients undergoing primary percutaneous coronary intervention.
abstract: OBJECTIVE
  We investigated the association between platelet indices and the severity of coronary artery disease (CAD) in patients with ST-segment-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PPCI).
  
  
  METHODS
  A total of 484 consecutive patients who were routinely referred to coronary angiography for STEMI and 81 age- and gender-matched patients with normal coronary arteries were included in the present study. We analyzed the relation between the platelet distribution width (PDW) and the angiographic severity of CAD. The SYNTAX score was used for assessing the severity of coronary atherosclerosis.
  
  
  RESULTS
  The mean platelet volume (MPV), the plateletcrit (PCT) and the neutrophil levels were significantly higher in the STEMI group than in the control group. Patients with an elevated SYNTAX score (>32) had higher PDW values. The levels of plateletcrit and the estimated glomerular filtration rate (eGFR) were lower in the high SYNTAX score group compared to the moderate-to-low SYNTAX score group. The PDW was positively correlated with age (r = 0.128, p=0.004) and SYNTAX score (r = 0.209, p<0.001). There was a mild, significant inverse association between the PDW level and the eGFR (r = -0.101, p=0.049), the mean platelet volume (MPV) (r = -290, p<0.001) and the PCT (r = -345, p<001). Using multivariate logistic regression analysis, we found that age (OR = 1.046, 95% CI 1.013-1.079, p=0.005), diabetes (OR = 4.779, 95% CI 2.339-9.767, p<0.001) and PDW (OR = 1.229, 95% CI 1.072-1409, p=0.003) were independent correlates of high SYNTAX score.
  
  
  CONCLUSIONS
  Platelet distribution width, an inexpensive and easily measurable laboratory variable, is independently associated with high SYNTAX score.
authors.affiliation: Department of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla, Turkey fatihakin@mu.edu.tr fatih._akin@hotmail.com.
authors.forename: Fatih
authors.initials: F
authors.lastname: Akin
authors.affiliation: Department of Cardiology, Bağcılar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Ayca
authors.affiliation: Department of Cardiology, Yucelen Hospital, Mugla, Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Kose
authors.affiliation: Department of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Altun
authors.affiliation: Department of Cardiology, Bağcılar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Avsar
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Celik
authors.affiliation: Department of Cardiology, Acıbadem University School of Medicine, Turkey.
authors.forename: Seckin
authors.initials: S
authors.lastname: Satilmis
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Eksik
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Okuyan
mesh_terms: D001792:Blood Platelets; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D062645:Percutaneous Coronary Intervention; D012720:Severity of Illness Index
keywords: SYNTAX score; platelet indices; primary percutaneous coronary intervention