title: Burden of HIV-Related Neuropathic Pain in the United States.
abstract: BACKGROUND
  HIV-related neuropathic pain (HIV-NeP) is common; however, the burden of HIV-NeP is not well-understood.
  
  
  METHODS
  The cross-sectional study aimed to characterize the HIV-NeP burden. A total of 103 patients with HIV-NeP recruited during routine office visits completed a questionnaire to assess patient-reported outcomes, including pain severity, health status, sleep, mood, and lost productivity. Physicians completed a 6-month retrospective chart review.
  
  
  RESULTS
  The sample was predominantly male and not employed for pay. A majority (75.7%) of patients experienced moderate or severe pain. Pain interference, general health, physical health, and depression were worse among patients with more severe pain (all Ps < .006). Most (87.4%) patients were prescribed at least 1 medication for NeP. HIV-related neuropathic pain was associated with 36.1% work impairment. Adjusted annualized costs increased with increasing pain severity (P < .0001).
  
  
  CONCLUSIONS
  The impact of HIV-NeP on health status, physical function, and depression increases with severity, resulting in substantial clinical and economic burden.
authors.affiliation: Covance Market Access Services Inc, San Diego, CA, USA.
authors.forename: Rachael
authors.initials: R
authors.lastname: Mann
authors.affiliation: Pfizer Inc, New York, NY, USA alesia.sadosky@pfizer.com.
authors.forename: Alesia
authors.initials: A
authors.lastname: Sadosky
authors.affiliation: Covance Market Access Services Inc, Gaithersburg, MD, USA.
authors.forename: Caroline
authors.initials: C
authors.lastname: Schaefer
authors.affiliation: Covance Market Access Services Inc, Gaithersburg, MD, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Baik
authors.affiliation: Pfizer Inc, New York, NY, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Parsons
authors.affiliation: Rehabilitation Institute of Michigan/Wayne State University, Detroit, MI, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Nieshoff
authors.affiliation: Oregon Health & Science University, Portland, OR, USA.
authors.forename: Brett R
authors.initials: BR
authors.lastname: Stacey
authors.affiliation: Palm Beach Neurological Center, Palm Beach Gardens, FL, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Tuchman
authors.affiliation: International Clinical Research Institute, Overland Park, KS, USA.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Nalamachu
mesh_terms: D000328:Adult; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy / Q000191:economics* / Q000209:etiology; D012189:Retrospective Studies; D014481:United States; D055815:Young Adult
keywords: HIV; burden of illness; costs; health care resource use; neuropathic pain; pain assessment; productivity; quality of life