title: Prevalence of Toxoplasma gondii infection in brain and heart by Immunohistochemistry in a hospital-based autopsy series in Durango, Mexico.
abstract: The presence of tissue cysts of Toxoplasma gondii has only poorly been investigated in autopsy series. We determined the presence of T. gondii cysts in a series of 51 autopsies in a public hospital using immunohistochemistry of brain and heart tissues. The association of tissue cysts with the general characteristics of the autopsy cases was also investigated. Of the 51 cases studied, five (9.8%) were positive by immunohistochemistry for T. gondii cysts in the brain. None of the heart specimens was positive for T. gondii cysts. The presence of T. gondii cysts in brains did not vary with age, sex, birthplace, residence, education, occupation, or the presence of pathology in the brain. In contrast, multivariate analysis showed that the presence of T. gondii cysts was associated with undernourishment (OR = 33.90; 95% CI: 2.82-406.32; P = 0.005). We demonstrated cerebral T. gondii cysts in an autopsy series in Durango City, Mexico. Results suggest that T. gondii can be more readily found in brain than in heart of infected individuals. This is the first report of an association between the presence of T. gondii in brains and undernourishment.
authors.affiliation: Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State , Avenida Universidad S/N, 34000 Durango, Mexico.
authors.forename: Cosme
authors.initials: C
authors.lastname: Alvarado-Esquivel
authors.affiliation: Institute for Scientific Research "Dr. Roberto Rivera-Damm", Juárez University of Durango State , Avenida Universidad S/N, 34000 Durango, Mexico.
authors.forename: Luis Francisco
authors.initials: LF
authors.lastname: Sánchez-Anguiano
authors.affiliation: Hospital General, Servicios de Salud de Durango , Durango, México, Cuauhtémoc 225 norte, 34000 Durango, Mexico.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Mendoza-Larios
authors.affiliation: Institute for Scientific Research "Dr. Roberto Rivera-Damm", Juárez University of Durango State , Avenida Universidad S/N, 34000 Durango, Mexico.
authors.forename: Jesús
authors.initials: J
authors.lastname: Hernández-Tinoco
authors.affiliation: Hospital General, Servicios de Salud de Durango , Durango, México, Cuauhtémoc 225 norte, 34000 Durango, Mexico.
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Pérez-Ochoa
authors.affiliation: Institute for Scientific Research "Dr. Roberto Rivera-Damm", Juárez University of Durango State , Avenida Universidad S/N, 34000 Durango, Mexico.
authors.forename: Elizabeth Irasema
authors.initials: EI
authors.lastname: Antuna-Salcido
authors.affiliation: Hospital General, Servicios de Salud de Durango , Durango, México, Cuauhtémoc 225 norte, 34000 Durango, Mexico.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Rábago-Sánchez
authors.affiliation: Institute for Microbiology and Hygiene , Campus Benjamin Franklin, Charité Medical School, Hindenburgdamm 27, D-12203 Berlin, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Liesenfeld
keywords: Toxoplasma gondii; brain; heart; immunohistochemistry; postmortem examinations; prevalence