title: Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index.
abstract: OBJECTIVE
  In the present study, we evaluated the influence of lipoprotein lipase (LPL) and apolipoprotein (apo) E polymorphisms on lipid concentrations of 178 Greek men of similar age with coronary heart disease (CHD), but varying body mass index (BMI).
  
  
  METHODS
  Patients were divided according to their BMI (in kg/m²) into three groups: lean (BMI = 20-24.9), overweight (BMI = 25-29.9), and obese (BMI ≥ 30). Polymorphisms of LPL (HindIII, S447X) and apo E (ε2, ε3, ε4), and lipid parameters were studied.
  
  
  RESULTS
  There was a negative correlation between BMI and high-density lipoprotein cholesterol (HDL-C) concentration (r = -0.272, p < 0.001), as has already been described. Lean homozygotes for the HindIII(+) allele had higher HDL-C levels compared to lean homozygotes for the HindIII(-) allele (p = 0.012). No correlation was found between S447X or apo E polymorphisms and BMI or plasma lipids in any group. Overweight men with the ε3/ε3 and SS genotypes had higher triglycerides concentration compared with overweight men with ε3/ε3 and SX (p = 0.002).
  
  
  CONCLUSIONS
  The HindIII polymorphism alone may influence HDL-C concentration in lean men, in contrast to S447X alone, which has no influence on any lipid parameters. However, the S447X and apo E polymorphisms may have a synergetic effect and alter plasma triglyceride concentration in overweight men.
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Harokopio University, Athens, Greece.
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.affiliation: Harokopio University, Athens, Greece.
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece, Royal Free Hospital-University College of London (UCL), London, UK.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vasiliadis
authors.affiliation: Cardiology Department, Thriassio General Hospital, Athens, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Giannakopoulou
authors.affiliation: Cardiology Department, Thriassio General Hospital, Athens, Greece.
authors.forename: Peggy M
authors.initials: PM
authors.lastname: Kostakou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Vartela
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Sophie
authors.initials: S
authors.lastname: Mavrogeni
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000235:genetics; D006115:Greece; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics; D050177:Overweight / Q000097:blood / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D008076:Cholesterol, HDL; C548261:LPL protein, human; D008071:Lipoprotein Lipase