title: Influence of polymorphisms in insulin-like growth factor-1 on the risk of osteoporosis in a Chinese postmenopausal female population.
abstract: We conducted a case-control study in a Chinese postmenopausal population, and explore the potential role of the promoter region variation of the IGF-1 gene in bone mineral density and osteoporosis risk. 485 postmenopausal women with a primary diagnosis of osteoporosis and 485 age-matched controls were selected between 2012 and 2014. The Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was used for rs35767, rs2288377 and rs5742612 of IGF-1 genotyping. By conditional regression analysis, individuals carrying TT genotype and CT+TT genotype of rs35767 were found to be correlated with an elevated risk of osteoporosis, with adjusted ORs (95% CI) of 1.90 (1.23-2.93) and 1.35 (1.04-1.76), respectively. Our study found that CT+TT genotype of rs35767 was significantly associated with moderate increased risk of osteoporosis in smokers and drinkers, and the ORs (95% CI) were 2.11 (1.06-4.20) and 2.36 (1.29-4.32), respectively. We found that those carrying CT+TT genotype of rs35767 had a significant lower BMD levels at L1-L4 vertebrae, femoral neck, total hip and trochanter compared to those with CC genotype. Our study suggests that TT genotype and CT+TT genotype of IGF-I rs35767 were associated with risk of osteoporosis and BMD levels.
authors.affiliation: Department of Spine Surgery, The Affiliated General Hospital of Guangzhou Military Region of Southern Medical University Guangzhou, China ; Department of Spine Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Spine Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot, China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Xing
authors.affiliation: Department of Spine Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Inner Mongolia People's Hospital Hohhot, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Jiang
authors.affiliation: Department of Spine Surgery, The Affiliated General Hospital of Guangzhou Military Region of Southern Medical University Guangzhou, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xia
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D044466:Asian People / Q000235:genetics; D015519:Bone Density / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: Insulin-like growth factors; bone mineral density; osteoporosis; polymorphism; women