title: RET polymorphisms might be the risk factors for thyroid cancer.
abstract: OBJECTIVE
  The purpose of the study is to investigate the relationship between rs1799939, rs1800858 and rs74799832 polymorphisms of RET with thyroid cancer (TC) susceptibility.
  
  
  METHODS
  Genotypes distribution of control groups were tested by Hardy-Weinberg equilibrium (HWE). Rs1799939, rs1800858 and rs74799832 polymorphisms of RET were researched in 135 patients with TC and 135 healthy people using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Odds ratio (OR) with 95% confidence interval (CI) were calculated to evaluate the association between RET polymorphisms and the risk of TC by Chi-squared test.
  
  
  RESULTS
  Genotypes frequencies of the control group were consistent with HWE. The frequency of genotype AA and allele A in rs1799939 were significantly higher in patients with TC than controls (OR=3.768, P=0.046; OR=1.695, P=0.035). Genotype GG and allele G of rs1800858 remarkably increased the risk of TC (OR=2.149, P=0.039; OR=1.45, P=0.039). Moreover, CC genotype and C allele in rs74799832 polymorphism was related with TC susceptibility. (OR=2.28, P=0.049; OR=1.566, P=0.049).
  
  
  CONCLUSIONS
  In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Central South University Changsha 410078, China.
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Huang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Central South University Changsha 410078, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human
keywords: RET; polymorphisms; thyroid cancer