title: Animal models of respiratory syncytial virus infection and disease.
abstract: The study of human respiratory syncytial virus pathogenesis and immunity has been hampered by its exquisite host specificity, and the difficulties encountered in adapting this virus to a murine host. The reasons for this obstacle are not well understood, but appear to reflect, at least in part, the inability of the virus to block the interferon response in any but the human host. This review addresses some of the issues encountered in mouse models of respiratory syncytial virus infection, and describes the advantages and disadvantages of alternative model systems.
authors.affiliation: Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA, United States.
authors.forename: Randy E
authors.initials: RE
authors.lastname: Sacco
authors.affiliation: Center for Immunity and Inflammation, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, United States.
authors.forename: Russell K
authors.initials: RK
authors.lastname: Durbin
authors.affiliation: Center for Immunity and Inflammation, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, United States; Department of Pathology, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, United States. Electronic address: durbinje@njms.rutgers.edu.
authors.forename: Joan E
authors.initials: JE
authors.lastname: Durbin
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000235:genetics / Q000502:physiology*