title: Two cases of bilateral lung transplantation combined with intracardiac repair and pulmonary artery replacement: perioperative managements based on the left ventricular function.
abstract: We report on two patients who underwent bilateral lung transplantation (BLTx) combined with cardiac surgery. Patient 1 was a female whose pulmonary hypertension resulted from a congenital atrial septal defect (ASD) and idiopathic pulmonary arterial hypertension. She had a very small left ventricle (LV). We initiated venoarterial extracorporeal membrane oxygenation (ECMO) before induction of general anesthesia. She underwent ASD patch closure, pulmonary artery replacement, and BLTx under cardiopulmonary bypass (CPB). At the weaning from CPB, primary graft dysfunction and pulmonary edema induced by LV diastolic dysfunction was apparent. We gradually decreased the ECMO support and eventually weaned off the ECMO on the 4th postoperative day (POD) and the ventilator on the 29th POD. Patient 2 was a male with Eisenmenger syndrome, which resulted from ASD and ventricular septal defect (VSD). He had a normal LV. General anesthesia was induced smoothly without ECMO. He underwent ASD and VSD patch closure, pulmonary artery replacement, and BLTx under CPB. Weaning from CPB proceeded smoothly. These patients needed different management because of their different LV function. Especially, perioperative management of the BLTx patient with LV diastolic dysfunction was difficult. Assessment of perioperative cardiac function is very important in BLTx combined with cardiac surgery.
authors.affiliation: Department of Anesthesiology, Tohoku University Hospital, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan. h-toyama@umin.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Toyama
authors.affiliation: Department of Anesthesiology, Tohoku University Hospital, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan.
authors.forename: Kazutomo
authors.initials: K
authors.lastname: Saitoh
authors.affiliation: Department of Anesthesiology, Tohoku University Hospital, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takei
authors.affiliation: Department of Anesthesiology, Tohoku University Hospital, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ejima
authors.affiliation: Department of Anesthesiology, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Kurosawa
authors.affiliation: Department of Anesthesiology, Tohoku University Hospital, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Yamauchi
mesh_terms: D000328:Adult; D006348:Cardiac Surgical Procedures / Q000379:methods; D002315:Cardiopulmonary Bypass / Q000379:methods; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000601:surgery; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D011651:Pulmonary Artery / Q000601:surgery*; D011654:Pulmonary Edema / Q000209:etiology; D016277:Ventricular Function, Left
keywords: Bilateral lung transplantation; Eisenmenger syndrome; Intracardiac repair; Left ventricular diastolic dysfunction; Pulmonary artery replacement