title: Effect of serum cholesterol on bone mineral density in normal-weight children and adolescents.
abstract: We investigated whether there is a relationship between serum cholesterol and bone mineral density (BMD), independent of BMI in children and adolescents. This study was based on data from the KNHANES 2009-2010. The data for 1557 children and adolescents were analyzed and classified into three groups: underweight, normal-weight, and overweight. We analyzed the relationships between serum cholesterol and BMD z-scores. Whole body BMD z-score was revealed as an inverse association with the serum cholesterol quartile in only normal-weight group (p=0.008). Serum cholesterol level correlated more inversely with BMD z-score in normal-weight boys (r2=0.040, p=0.002) than in girls (r2=0.019, p=0.042). Multivariate regression analysis identified serum cholesterol as association with BMD in normal-weight (r2=0.020, p=0.002). Serum cholesterol concentration may be a detrimental risk factor for BMD in normal-weight children and adolescents independent of BMI.
authors.forename: Han Hyuk
authors.initials: HH
authors.lastname: Lim
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000097:blood*; D012307:Risk Factors; D013851:Thinness / Q000097:blood*
chemical_list: D002784:Cholesterol