title: Multifunctional magnetic-hollow gold nanospheres for bimodal cancer cell imaging and photothermal therapy.
abstract: Multifunctional nanocomposites combining imaging and therapeutic functions have great potential for cancer diagnosis and therapy. In this work, we developed a novel theranostic agent based on hollow gold nanospheres (HGNs) and superparamagnetic iron oxide nanoparticles (SPIO). Taking advantage of the excellent magnetic properties of SPIO and strong near-infrared (NIR) absorption property of HGNs, such nanocomposites were applied to targeted magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) of cancer cells. In vitro results demonstrated they displayed significant contrast enhancement for T2-weighted MRI and strong PAI signal enhancement. Simultaneously, the nanocomposites exhibited a high photothermal effect under the irradiation of the near-infrared laser and can be used as efficient photothermal therapy (PTT) agents for selective killing of cancer cells. All these results indicated that such nanocomposites combined with MRI-PAI and PTT functionality can have great potential for effective cancer diagnosis and therapy.
authors.forename: Ling-Yu
authors.initials: LY
authors.lastname: Bai
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: An
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.forename: Meng-Yao
authors.initials: MY
authors.lastname: Qin
authors.forename: Bi-Yun
authors.initials: BY
authors.lastname: Fang
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Xuan
authors.forename: Xiao-Shuai
authors.initials: XS
authors.lastname: Zhang
authors.forename: Yuan-Di
authors.initials: YD
authors.lastname: Zhao
authors.forename: Zhi-Ya
authors.initials: ZY
authors.lastname: Ma
mesh_terms: D003287:Contrast Media; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D028022:Low-Level Light Therapy / Q000295:instrumentation* / Q000379:methods; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D054118:Nanospheres / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy; D010316:Particle Size; D061088:Photoacoustic Techniques / Q000295:instrumentation* / Q000379:methods
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D006046:Gold