title: Unexpected Enhancement in Antibacterial Activity of N-Halamine Polymers from Spheres to Fibers.
abstract: Preventing bacterial infections is a main focus of medical care. Antibacterial agents with broad and excellent disinfection capability against pathogenic bacteria are in fact urgently required. Herein, a novel strategy for the development of N-halamine polymers from spheres to fibers using a combined copolymerization-electrospinning-chlorination technique was reported, allowing fight against bacterial pathogen. Optimizing the process conditions, e.g., comonomer molar ratio, concentration of electrospinning solution, chlorination order, and chlorination period, resulted in the formation of N-halamine fibers with controllable morphology. N-Halamine polymers were tested against two common bacterial pathogens, Escherichia coli and Staphylococcus aureus, and were found to be extremely potent against both bacteria, suggesting that they possess powerful sterilizing properties. Remarkably, compared with those with sphere morphology, N-halamine fibers show unexpected enhancement toward both pathogens possibly because of their shape (fiber morphology), surface state (rough surfaces), and surface charge (positive zeta potentials). It is believed that this approach has great potential to be utilized in various fields where antifouling and antibacterial properties are highly required.
authors.affiliation: †College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Kang
authors.affiliation: †College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Han
authors.affiliation: †College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: †College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Gao
authors.affiliation: ‡College of Science, Inner Mongolia Agricultural University, Hohhot 010018, People's Republic of China.
authors.forename: Shi
authors.initials: S
authors.lastname: Lan
authors.affiliation: §College of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, People's Republic of China.
authors.forename: Linghan
authors.initials: L
authors.lastname: Xiao
authors.affiliation: †College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: ⊥College of Chemistry, Jilin University, Changchun 130021, People's Republic of China.
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.affiliation: †College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Harnoode
authors.initials: H
authors.lastname: Chokto
authors.affiliation: †College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Alideertu
authors.initials: A
authors.lastname: Dong
mesh_terms: D000588:Amines / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D004926:Escherichia coli / Q000187:drug effects; D054879:Halogenation; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D011108:Polymers
keywords: N-halamine; antibacterial; enhancement; fiber; sphere