title: A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides?
abstract: BACKGROUND
  This was a meta-analysis and systematic review to determine the global prevalence of the mitochondrially encoded 12S RNA (MT-RNR1) genetic mutation in order to assess the need for neonatal screening prior to aminoglycoside therapy.
  
  
  METHODS
  A comprehensive search of MEDLINE, EMBASE, Ovid, Database of Abstracts of Reviews of Effect, Cochrane Library, Clinical Evidence and Cochrane Central Register of Trials was performed including cross-referencing independently by 2 assessors. Selections were restricted to human studies in English. Meta-analysis was done with MetaXL 2013.
  
  
  RESULTS
  Forty-five papers out of 295 met the criteria. Pooled prevalence in the general population for MT-RNR1 gene mutations (A1555G, C1494T, A7445G) was 2% (1-4%) at 99%.
  
  
  CONCLUSIONS
  Routine screening for MT-RNR1 mutations in the general population prior to treatment with aminoglycosides appear desirable but poorly supported by the weak level of evidence available in the literature. Routine screening in high-risk (Chinese and Spanish) populations appear justified.
authors.affiliation: Department of ENT, University of Abuja Teaching Hospital and College of Health Sciences, University of Abuja, Abuja, Nigeria.
authors.forename: Titus S
authors.initials: TS
authors.lastname: Ibekwe
authors.forename: Sanjiv K
authors.initials: SK
authors.lastname: Bhimrao
authors.forename: Brian D
authors.initials: BD
authors.lastname: Westerberg
authors.forename: Frederick K
authors.initials: FK
authors.lastname: Kozak
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects* / Q000627:therapeutic use; D005820:Genetic Testing / Q000191:economics*; D006801:Humans; D007231:Infant, Newborn; D008928:Mitochondria / Q000235:genetics*; D009154:Mutation; D015995:Prevalence; D012335:RNA, Ribosomal / Q000235:genetics*
chemical_list: D000617:Aminoglycosides; D012335:RNA, Ribosomal; C075526:RNA, ribosomal, 12S