title: Successful Treatment With Total Skin Electron Beam Therapy in a Child With Isolated Cutaneous Relapsed AML.
abstract: A 9-year-old girl diagnosed with acute myeloblastic leukemia M4 developed isolated cutaneous relapse. She was given chemotherapy including idarubicin, fludarabine, and cytarabine. Although she developed very severe pancytopenia, increase in the number and size of the lesions was seen. Total skin electron beam therapy was applied to the skin lesions for a total of 18 Gy. All lesions responded to total skin electron beam therapy, some of them completely disappeared. After resolution of the skin findings, she underwent bone marrow transplantation from her matched brother. Twenty-six months after hematopoietic stem cell transplantation she is alive without any event.
authors.affiliation: *Pediatric Hematology †Radiation Oncology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.
authors.forename: Deniz Yilmaz
authors.initials: DY
authors.lastname: Karapinar
authors.forename: Serra A
authors.initials: SA
authors.lastname: Kamer
authors.forename: Nihal
authors.initials: N
authors.lastname: Karadaş
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Anacak
authors.forename: Buket E
authors.initials: BE
authors.lastname: Delcastello
authors.forename: Can
authors.initials: C
authors.lastname: Balkan
authors.forename: Kaan
authors.initials: K
authors.lastname: Kavakli
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Aydinok
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002648:Child; D003561:Cytarabine / Q000008:administration & dosage; D004583:Electrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000139:chemically induced / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011379:Prognosis; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology / Q000532:radiotherapy*; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D003561:Cytarabine; D014740:Vidarabine; C024352:fludarabine; D015255:Idarubicin