title: Heart rate and systolic blood pressure variability on recently diagnosed diabetics.
abstract: BACKGROUND
  Diabetes affects approximately 250 million people in the world. Cardiovascular autonomic neuropathy is a common complication of diabetes that leads to severe postural hypotension, exercise intolerance, and increased incidence of silent myocardial infarction.
  
  
  OBJECTIVE
  To determine the variability of heart rate (HR) and systolic blood pressure (SBP) in recently diagnosed diabetic patients.
  
  
  METHODS
  The study included 30 patients with a diagnosis of type 2 diabetes of less than 2 years and 30 healthy controls. We used a Finapres® device to measure during five minutes beat-to-beat HR and blood pressure in three experimental conditions: supine position, standing position, and rhythmic breathing at 0.1 Hz. The results were analyzed in the time and frequency domains.
  
  
  RESULTS
  In the HR analysis, statistically significant differences were found in the time domain, specifically on short-term values such as standard deviation of NN intervals (SDNN), root mean square of successive differences (RMSSD), and number of pairs of successive NNs that differ by more than 50 ms (pNN50). In the BP analysis, there were no significant differences, but there was a sympathetic dominance in all three conditions. The baroreflex sensitivity (BRS) decreased in patients with early diabetes compared with healthy subjects during the standing maneuver.
  
  
  CONCLUSIONS
  There is a decrease in HR variability in patients with early type 2 diabetes. No changes were observed in the BP analysis in the supine position, but there were changes in BRS with the standing maneuver, probably due to sympathetic hyperactivity.
authors.affiliation: Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México Distrito Federal, MX.
authors.forename: Anaclara
authors.initials: A
authors.lastname: Michel-Chávez
authors.affiliation: Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México Distrito Federal, MX.
authors.forename: Bruno
authors.initials: B
authors.lastname: Estañol
authors.affiliation: Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México Distrito Federal, MX.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Gien-López
authors.affiliation: Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México Distrito Federal, MX.
authors.forename: Adriana
authors.initials: A
authors.lastname: Robles-Cabrera
authors.affiliation: Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México Distrito Federal, MX.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Huitrado-Duarte
authors.affiliation: Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México Distrito Federal, MX.
authors.forename: René
authors.initials: R
authors.lastname: Moreno-Morales
authors.affiliation: Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México Distrito Federal, MX.
authors.forename: Brayans
authors.initials: B
authors.lastname: Becerra-Luna
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology; D013997:Time Factors