title: Squamous cell carcinoma of the lung with highly proliferating fibromatosis-like stroma: a rare phenomenon.
abstract: Few cases of carcinoma with exuberant stromal proliferation have been documented, apart from scirrhous carcinoma. To the best of our knowledge, previous cases of carcinoma exhibiting exuberant stromal proliferation have exclusively been reported in the thyroid gland, specifically as papillary carcinoma. The exuberant stromal proliferation has been recognized to be similar to either fibromatosis or nodular fasciitis. Herein, we report a case of a 74-year-old Japanese man whose tumor in the upper lobe of his right lung displayed highly proliferating stroma with dispersed, poorly differentiated squamous cell carcinoma nests. The stromal spindle cells (fibroblasts/myofibroblasts) had similar molecular profiles to those typically observed in fibromatosis rather than nodular fasciitis, resulting in the designation of "fibromatosis-like" stroma. The presence of carcinoma cells, along with stromal cells, expressing TGF-β in this case likely fostered continuous stromal proliferation, presumably in conjunction with the unique microenvironment in which the carcinoma cells were present.
authors.affiliation: Department of Pathology, Shizuoka Saiseikai General Hospital Shizuoka, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Tajima
authors.affiliation: Departments of Chest Surgery, Fujieda Municipal General Hospital Fujieda, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takanashi
authors.affiliation: Department of Pathology, Fujieda Municipal General Hospital Fujieda, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Koda
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D049109:Cell Proliferation; D005350:Fibroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D011013:Pneumonectomy; D017154:Stromal Cells / Q000737:chemistry / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor
keywords: Fibromatosis; TGF-β; lung; squamous cell carcinoma