title: Regional Homogeneity: A Multimodal, Multiscale Neuroimaging Marker of the Human Connectome.
abstract: Much effort has been made to understand the organizational principles of human brain function using functional magnetic resonance imaging (fMRI) methods, among which resting-state fMRI (rfMRI) is an increasingly recognized technique for measuring the intrinsic dynamics of the human brain. Functional connectivity (FC) with rfMRI is the most widely used method to describe remote or long-distance relationships in studies of cerebral cortex parcellation, interindividual variability, and brain disorders. In contrast, local or short-distance functional interactions, especially at a scale of millimeters, have rarely been investigated or systematically reviewed like remote FC, although some local FC algorithms have been developed and applied to the discovery of brain-based changes under neuropsychiatric conditions. To fill this gap between remote and local FC studies, this review will (1) briefly survey the history of studies on organizational principles of human brain function; (2) propose local functional homogeneity as a network centrality to characterize multimodal local features of the brain connectome; (3) render a neurobiological perspective on local functional homogeneity by linking its temporal, spatial, and individual variability to information processing, anatomical morphology, and brain development; and (4) discuss its role in performing connectome-wide association studies and identify relevant challenges, and recommend its use in future brain connectomics studies.
authors.affiliation: Key Laboratory of Behavioral Science, Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Laboratory for Functional Connectome and Development, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Behavioral Science, Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Laboratory for Functional Connectome and Development, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Faculty of Psychology, Southwest University, Beibei, Chongqing, China Department of Psychology, School of Education Science, Guangxi Teachers Education University, Nanning, Guangxi, China zuoxn@psych.ac.cn jiangll@psych.ac.cn.
authors.forename: Xi-Nian
authors.initials: XN
authors.lastname: Zuo
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D063132:Connectome / Q000379:methods; D006801:Humans; D009415:Nerve Net / Q000033:anatomy & histology*; D059906:Neuroimaging
keywords: centrality; connectome; connectomics; local connectivity; regional homogeneity