title: Characterization of VP1 gene of coxsackievirus A16 prevalent among hand foot mouth disease suffered children in Taizhou, P. R. China, between 2010 and 2013.
abstract: A total of 453 strains of Coxsackievirus A16 (CV-A16) were screened out of 1,509 hand-foot-mouth disease (HFMD) samples collected in Taizhou during the period from 2010 to 2013. And between first quarter of 2011 and first quarter of 2013, an outbreak of CV-A16 was found among the HFMD sufferers in Taizhou. Phylogenic analysis of VP1 sequences indicated a major CV-A16 sub-group in Taizhou, whose change pattern of effective population sizes was found to be similar to the pattern of the actual percentage changes of CV-A16 during the outbreak over the same period. More importantly, the sub-group all displayed a Leu (L) to Met (M) mutation at site-23 of capsid VP1 which might be correlated with the outbreak of CV-A16 in Taizhou.
authors.affiliation: Taizhou Center for Disease Control and Prevention, Taizhou, China.
authors.forename: Zhilong
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Taizhou Center for Disease Control and Prevention, Taizhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zha
mesh_terms: D019943:Amino Acid Substitution; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D004770:Enterovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017720:Molecular Epidemiology; D020125:Mutation, Missense; D010802:Phylogeny; D015678:Viral Structural Proteins / Q000235:genetics*
chemical_list: D015678:Viral Structural Proteins
keywords: Coxsackievirus A16 (CV-A16); VP1 characterization; hand-foot-mouth disease (HFMD)