title: Sinusoidal obstructive syndrome with hypereosinophilia successfully treated with prednisolone.
abstract: A 60-year-old man was admitted to Tenri Hospital complaining of erythema and abdominal distention. There were marked liver damage and hypereosinophilia. The patient was suffering from portal hypertension and coagulation disorder. We diagnosed the patient clinically as suffering from veno-occlusive disease, or sinusoidal obstructive syndrome (SOS). The pathological finding of the liver biopsy specimen was compatible with SOS. All of the manifestations, liver function test, and hemodynamics subsided shortly after administration of steroid treatment and ursodeoxycholic acid. The pathogenesis was not identified but some allergic reaction was suspected.
authors.affiliation: Department of Gastroenterology and Hepatology, Kyoto University Graduate School, 54 Shogoin-kawahara cho, Sakyo-ku, Kyoto, 606-8507, Japan. yyamaga5@orion.ocn.ne.jp.|Department of Gastroenterology and Hepatology, Tenri Hospital, Tenri, Japan. yyamaga5@orion.ocn.ne.jp.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamaga
authors.affiliation: Department of General Internal Medicine, Tenri Hospital, Tenri, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Tsugihashi
authors.affiliation: Department of Gastroenterology and Hepatology, Kansai Electric Power Company Hospital, Osaka, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Radiology, Tenri Hospital, Tenri, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Taniguchi
authors.affiliation: Department of Pathology, Tenri Hospital, Tenri, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Honjou
authors.affiliation: Department of Pathology, Kurume University, Kurume, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
keywords: Eosinophil; Portal hypertension; Sinusoidal obstructive syndrome (SOS); Sonazoid; Steroid; Veno-occlusive disease (VOD)