title: Prolonged neuropsychiatric effects following management of chloroquine intoxication with psychotropic polypharmacy.
abstract: Susceptibility to quinoline antimalarial intoxication may reflect individual genetic and drug-induced variation in neuropharmacokinetics. In this report, we describe a case of chloroquine intoxication that appeared to be prolonged by subsequent use of multiple psychotropic medications. This case highlights important new considerations for the management of quinoline antimalarial intoxication.
authors.affiliation: University of San Francisco San Francisco, California.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Maxwell
authors.affiliation: Johns Hopkins Bloomberg School of Public Health Baltimore, Maryland.
authors.forename: Remington L
authors.initials: RL
authors.lastname: Nevin
authors.affiliation: University of California, San Diego San Diego, California.
authors.forename: Stephen
authors.initials: S
authors.lastname: Stahl
authors.affiliation: Veterans Administration Medical Center Portland, Oregon.
authors.forename: Jerald
authors.initials: J
authors.lastname: Block
authors.affiliation: Kaiser Permanente Berkeley, California.
authors.forename: Sarah
authors.initials: S
authors.lastname: Shugarts
authors.affiliation: University of California, San Francisco San Francisco, California.
authors.forename: Alan H B
authors.initials: AH
authors.lastname: Wu
authors.affiliation: University of California, San Francisco San Francisco, California.
authors.forename: Stephen
authors.initials: S
authors.lastname: Dominy
authors.affiliation: Centro de Especialidades Medicas de Siguatepeque Comayagua, Honduras.
authors.forename: Miguel Alonso
authors.initials: MA
authors.lastname: Solano-Blanco
authors.affiliation: In Private Practice Lafayette, California.
authors.forename: Sharon
authors.initials: S
authors.lastname: Kappelman-Culver
authors.affiliation: Stanford University Stanford, California.
authors.forename: Christopher
authors.initials: C
authors.lastname: Lee-Messer
authors.affiliation: Stanford University Stanford, California.
authors.forename: Jose
authors.initials: J
authors.lastname: Maldonado
authors.affiliation: University of California, San Francisco San Francisco, California ; Stanford University Stanford, California.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Maxwell
keywords: CYP2D6; Chloroquine; chronic effects; genetic polymorphisms; pharmacogenetics; psychosis; quinoline