title: [Correlation between the use of sodium bicarbonate and intraventricular hemorrhage in preterms].
abstract: BACKGROUND
  Being born preterm implies comorbidities, among them the risk of intraventricular hemorrhage (IVH). The use of sodium bicarbonate has been linked to the presence of IVH. The main purpose of this study was to determine if the infusion of sodium bicarbonate during the first 24 hours increases the risk of IVH in preterm infants.
  
  
  METHODS
  Our study is a cohort; we analyzed the files of 160 patients and divided them into two groups: one in which sodium bicarbonate was not used and another in which it was; this latter group was subdivided into two considering if the use was therapeutic of prophylactic.
  
  
  RESULTS
  In our total group of patients 10 % presented IVH; had a mean weight of 1500 g and 31 weeks of gestational age. The incidence of IVH was identical between both groups, although patients in which bicarbonate was used were more premature, unstable, and in worse clinical conditions.
  
  
  CONCLUSIONS
  Our data indicate the need of large scale studies to determine if the clinical benefits of the use of sodium bicarbonate outweigh the risk of IVH.
authors.affiliation: Servicio de Neonatología, División de Pediatría, Hospital Español de México, Distrito Federal, México. dragarciapasquel@gmail.com.
authors.forename: María José
authors.initials: MJ
authors.lastname: García-Pasquel
authors.forename: José
authors.initials: J
authors.lastname: Iglesias-Leboreiro
authors.forename: Isabel
authors.initials: I
authors.lastname: Bernardez-Zapata
mesh_terms: D000138:Acidosis / Q000188:drug therapy* / Q000517:prevention & control; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D007262:Infusions, Intravenous; D008297:Male; D012189:Retrospective Studies; D017693:Sodium Bicarbonate / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D017693:Sodium Bicarbonate
keywords: Hemorrhage; Premature infant; Sodium bicarbonate