title: Anti-Amnesic Effect of Fermented Ganoderma lucidum Water Extracts by Lactic Acid Bacteria on Scopolamine-Induced Memory Impairment in Rats.
abstract: This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine-induced memory impairment in rats. GW were fermented by the lactic acid bacterium Bifidobacterium bifidum (FGWB), followed by Lactobacillus sakei LI033 (FGWBL). To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally injected into rats 30 min before the behavioral tests. Step-through latencies of rats treated with primary fermented extracts (300 mg/kg, FGWB) and secondary fermented extracts (300 mg/kg, FGWBL) were significantly longer than those of rats treated with GW (300 mg/kg) in the retention trial of the multiple trial passive avoidance test. In the Morris water maze task, FGWBL significantly shortened escape latencies in training trials. Furthermore, swimming times within the target zone during the probe trial with FGWBL were significantly higher than the GW and FGWB treatments. In addition, acetylcholinesterase activities were lower in the brains of scopolamine-treated rats treated with FGWBL. These results suggest that FGWBL could be useful to enhance learning memory and cognitive function via cholinergic dysfunction.
authors.affiliation: Imsil Research Institute of Cheese Science, Jeonbuk 566-881, Korea.
authors.forename: Yu Jin
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Imsil Research Institute of Cheese Science, Jeonbuk 566-881, Korea.
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Yang
authors.affiliation: Imsil Research Institute of Cheese Science, Jeonbuk 566-881, Korea.
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Jo
authors.affiliation: Imsil Research Institute of Cheese Science, Jeonbuk 566-881, Korea.
authors.forename: Sang Cheon
authors.initials: SC
authors.lastname: Lee
authors.affiliation: Janghung Research Institute for Mushroom Industry, Jeonnam 529-851, Korea.
authors.forename: Tae Young
authors.initials: TY
authors.lastname: Park
authors.affiliation: Janghung Research Institute for Mushroom Industry, Jeonnam 529-851, Korea.
authors.forename: Bong Suk
authors.initials: BS
authors.lastname: Choi
authors.affiliation: Janghung Research Institute for Mushroom Industry, Jeonnam 529-851, Korea.
authors.forename: Kyoung Sun
authors.initials: KS
authors.lastname: Seo
authors.affiliation: Imsil Research Institute of Cheese Science, Jeonbuk 566-881, Korea.
authors.forename: Chang Ki
authors.initials: CK
authors.lastname: Huh
keywords: Ganoderma lucidum; Morris water maze test; fermentation; passive avoidance test; scopolamine