title: Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures.
abstract: The goal of the Brain Genomics Superstruct Project (GSP) is to enable large-scale exploration of the links between brain function, behavior, and ultimately genetic variation. To provide the broader scientific community data to probe these associations, a repository of structural and functional magnetic resonance imaging (MRI) scans linked to genetic information was constructed from a sample of healthy individuals. The initial release, detailed in the present manuscript, encompasses quality screened cross-sectional data from 1,570 participants ages 18 to 35 years who were scanned with MRI and completed demographic and health questionnaires. Personality and cognitive measures were obtained on a subset of participants. Each dataset contains a T1-weighted structural MRI scan and either one (n=1,570) or two (n=1,139) resting state functional MRI scans. Test-retest reliability datasets are included from 69 participants scanned within six months of their initial visit. For the majority of participants self-report behavioral and cognitive measures are included (n=926 and n=892 respectively). Analyses of data quality, structure, function, personality, and cognition are presented to demonstrate the dataset's utility.
authors.affiliation: Center for Brain Science, Harvard University , Cambridge, MA 02138, USA ; Department of Psychology, Harvard University , Cambridge, MA 02138, USA ; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114, USA ; Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.
authors.forename: Avram J
authors.initials: AJ
authors.lastname: Holmes
authors.affiliation: Center for Brain Science, Harvard University , Cambridge, MA 02138, USA ; Department of Psychology, Harvard University , Cambridge, MA 02138, USA ; Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.
authors.forename: Marisa O
authors.initials: MO
authors.lastname: Hollinshead
authors.affiliation: Center for Brain Science, Harvard University , Cambridge, MA 02138, USA.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: O'Keefe
authors.affiliation: Center for Brain Science, Harvard University , Cambridge, MA 02138, USA.
authors.forename: Victor I
authors.initials: VI
authors.lastname: Petrov
authors.affiliation: Center for Brain Science, Harvard University , Cambridge, MA 02138, USA ; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114, USA.
authors.forename: Gabriele R
authors.initials: GR
authors.lastname: Fariello
authors.affiliation: Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Wald
authors.affiliation: Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Fischl
authors.affiliation: Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Rosen
authors.affiliation: Center for Brain Science, Harvard University , Cambridge, MA 02138, USA ; Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.
authors.forename: Ross W
authors.initials: RW
authors.lastname: Mair
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114, USA ; Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.
authors.forename: Joshua L
authors.initials: JL
authors.lastname: Roffman
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114, USA.
authors.forename: Jordan W
authors.initials: JW
authors.lastname: Smoller
authors.affiliation: Center for Brain Science, Harvard University , Cambridge, MA 02138, USA ; Department of Psychology, Harvard University , Cambridge, MA 02138, USA ; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114, USA ; Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.
authors.forename: Randy L
authors.initials: RL
authors.lastname: Buckner
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D003071:Cognition; D003430:Cross-Sectional Studies; D003710:Demography; D023281:Genomics; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging; D057566:Self Report; D055815:Young Adult