title: Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense.
abstract: The eosinophil-derived neurotoxin (EDN/RNase2) and its divergent orthologs, the mouse eosinophil-associated RNases (mEars), are prominent secretory proteins of eosinophilic leukocytes and are all members of the larger family of RNase A-type ribonucleases. While EDN has broad antiviral activity, targeting RNA viruses via mechanisms that may require enzymatic activity, more recent studies have elucidated how these RNases may generate host defense via roles in promoting leukocyte activation, maturation, and chemotaxis. This review provides an update on recent discoveries, and highlights the versatility of this family in promoting innate immunity.
authors.affiliation: Inflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. hrosenberg@niaid.nih.gov.
authors.forename: Helene F
authors.initials: HF
authors.lastname: Rosenberg
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D047208:Eosinophil-Derived Neurotoxin / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism*; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D007113:Immunity, Innate; D010802:Phylogeny; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D016207:Cytokines; D011994:Recombinant Proteins; C479821:Ear2 protein, mouse; D047208:Eosinophil-Derived Neurotoxin
keywords: chemoattractant; evolution; inflammation; leukocyte