title: CD36 expression and lipid metabolism following an oral glucose challenge in South Asians.
abstract: OBJECTIVE
  To investigate lipid metabolism and the relationship with monocyte expression of the fatty acid translocase CD36 in South Asians.
  
  
  METHODS
  An observational study of South Asians whom as an ethnic group have - a higher risk of developing diabetes. The susceptibility to diabetes is coupled with an earlier and more rapid progression of micro-, and macro-vascular complications. Twenty-nine healthy South Asian participants [mean age 34.6 (8.9) years, 76.2% male, mean body-mass index 25.0 (5.2) kg/m(2)] were recruited from an urban residential area of central Birmingham (United Kingdom). The main outcomes measured were post prandial (30 min) and post absorptive (120 min) changes from fasting (0 min) in circulating lipoproteins, lipds and hormones, and monocyte expression of CD36 post injection of a 75 g oral glucose challenge. The inducements of variations of monocyte CD36 expression were analysed.
  
  
  RESULTS
  Our results showed evident changes in monocyte CD36 expression following the glucose challenge (P < 0.001). Non-esterified fatty acids (NEFA) levels decreased progressively during the challenge (P < 0.001), in contrast to increased cholesterol (but not triglyceride) concentrations within very low density lipoprotein (VLDL) and low density lipoprotein subfractions (P < 0.01). Levels of, glucose, serum triglycerides and high density lipoprotein cholesterol remained largely unchanged. Variations of monocyte CD36 were negatively (r = -0.47, P = 0.04) associated to fat from the diet and positively to carbohydrate from the diet (r = 0.65, P < 0.001).
  
  
  CONCLUSIONS
  These data suggest that the initiation of VLDL genesis follows the consumption of glucose within this population, inferring that the sequestration of NEFA from these particles happens due to the increased availability of CD36 receptors. While these are preliminary results, it would appear that lifestyle exposures have a role in moderating the expression of CD36.
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Jeetesh V
authors.initials: JV
authors.lastname: Patel
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Amitava
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Silvia
authors.initials: S
authors.lastname: Montoro-Garcia
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Eduard
authors.initials: E
authors.lastname: Shantsila
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Mushfique
authors.initials: M
authors.lastname: Alam
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Flinders
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Kathleen Al
authors.initials: KA
authors.lastname: Houlton
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Hughes
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Gregory Yh
authors.initials: GY
authors.lastname: Lip
authors.affiliation: Jeetesh V Patel, Amitava Banerjee, Silvia Montoro-Garcia, Eduard Shantsila, Elizabeth A Hughes, Gregory YH Lip, University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, B71 4HJ West Midlands, United Kingdom.
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Gill
keywords: CD36; Diabetes; Glucose; Lipoprotein; Macro-vascular; Micro-vascular; South Asians