title: Usability and utility of the CONSORT calculator for FSH starting doses: a prospective observational study.
abstract: This prospective, multicentre, observational study assessed usability and utility (co-primary endpoints) of the consistency in r-hFSH starting doses for individualized treatment (CONSORT) calculator in French routine clinical practice. Physicians first planned their recombinant human follicle-stimulating hormone (r-hFSH) starting dose. The CONSORT calculator was then used to recommend a starting dose. Data were collected for 197 women aged 18-35 years undergoing ovarian stimulation. The usability rate was high: 44/45 (97.8%) physicians found CONSORT user-friendly and easy to use for ≥75% of patients. Utility data showed that physicians followed the CONSORT recommendation for 89/197 (45.2%) patients. Reasons given for not following the CONSORT-calculated dose (N = 108) included: the CONSORT-calculated dose was too divergent from the planned dose (48.1%; 52/108) and/or the CONSORT-calculated dose did not correspond to the patient profile (46.3%; 50/108). The mean ± SD starting dose of r-hFSH planned by physicians was 163.9 ± 51.2 IU; the mean (SD) starting dose recommended by the CONSORT calculator was 119.7 ± 20.9 IU and the mean (SD) dose actually prescribed to patients was 151.7 ± 51.1 IU. Despite low physician-reported utility in this study, post-hoc analyses suggest the CONSORT calculator has potential for use in routine clinical practice.
authors.affiliation: Centre d'Assistance Médicale à la Procréation, CHU de Clermont-Ferrand, 1 Place Lucie et Raymond Aubrac, 63100 Clermont Ferrand, France. Electronic address: jlpouly@chu-clermontferrand.fr.
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Pouly
authors.affiliation: Clinique de la Muette, 46-48 Rue Nicolo, 75116 Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Olivennes
authors.affiliation: Unité d'Assistance Médicale à la Procréation, Service de Gynécologie-Obstétrique, Université Paris XII, Centre Hospitalier Intercommunal, 40 Avenue de Verdun, 94000 Créteil, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Massin
authors.affiliation: SOLADIS, 6-8 Rue Bellecombe, 69006 Lyon, France.
authors.forename: Médéric
authors.initials: M
authors.lastname: Celle
authors.affiliation: Merck Serono, 37 Rue Saint-Romain, 69008 Lyon, France.
authors.forename: Natacha
authors.initials: N
authors.lastname: Caizergues
authors.affiliation: Merck Serono, 37 Rue Saint-Romain, 69008 Lyon, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Contard
mesh_terms: D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D011446:Prospective Studies
chemical_list: D005640:Follicle Stimulating Hormone
keywords: FSH; IVF; assisted reproductive technology; dosing algorithm; ovarian stimulation; predictive factors