title: Treatment of recurrent metastatic uterine leiomyosarcoma of the spine: a multimodality approach using resection, radiosurgery, and chemotherapy.
abstract: The authors describe the case of a patient who initially presented with uterine leiomyosarcoma (LMS) that later metastasized to the spine. The patient was treated at another institution for her primary uterine LMS, undergoing resection followed by adjuvant chemotherapy. After several years of disease remission, the patient presented in January 2011 to the authors' institution with recurrent uterine LMS metastatic to the spine, which has been treated with multiple therapeutic modalities in a combination of surgery, radiosurgery, and chemotherapy. As a result of this approach, the patient has been progression free for 35 months since her presentation (April 2011 to March 2014). We herein describe our experience treating this patient with recurrent uterine LMS of the spine and suggest that patients with recurrent uterine LMSs should be considered for treatment using a multimodality approach with emphasis on enrollment into clinical trials.
authors.affiliation: Tulane University School of Medicine.|Department of Pathology, Tulane University.|Tulane Cancer Center, New Orleans.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Strong
authors.affiliation: Tulane University School of Medicine.
authors.forename: Trevor
authors.initials: T
authors.lastname: Rosenlof
authors.affiliation: Department of Radiation Oncology, East Jefferson General Hospital, Metairie.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Padmanabha
authors.affiliation: Tulane University School of Medicine.|Tulane Cancer Center, New Orleans.|Department of Medicine, Section of Hematology and Medical Oncology, Tulane University School of Medicine.
authors.forename: Roy S
authors.initials: RS
authors.lastname: Weiner
authors.affiliation: DEKK-TEC, Inc.; and.
authors.forename: Lee Roy
authors.initials: LR
authors.lastname: Morgan
authors.affiliation: Department of Neurosurgery, Ochsner Medical Center, New Orleans, Louisiana.
authors.forename: Marcus I
authors.initials: MI
authors.lastname: Ware
keywords: 4-demethyl-4-cholesteryloxycarbonylpenclomedine; DM-CHOC-PEN; DM-CHOC-PEN: 4-demethyl-4-cholesteryloxycarbonylpenclomedine; LMS = leiomyosarcoma; TAHBSO = total abdominal hysterectomy and bilateral salphingo-oophorectomy; TMZ = temozolomide; chemotherapy; multimodality treatment; oncology; radiosurgery; recurrence; spinal metastasis; uterine leiomyosarcoma