title: Four cytotoxic annonaceous acetogenins from the seeds of Annona squamosa.
abstract: Four new annonaceous acetogenins (ACGs), squamocin-I (1), II (2) and III (3) and squamoxinone-D (4), together with seven known ACGs (5-11), were isolated from the seeds of Annona squamosa. The structures of all isolates were elucidated and characterised by spectral and chemical methods. Compounds 1-4 were evaluated for their cytotoxicities against Hep G2, SMMC 7721, BEL 7402, BGC 803 and H460 human cancer cell lines. Compound 1 exhibited better potent activity than the positive compound and compound 3 shows selectively cytotoxical activity against H460 with IC50 values of 0.0492 μg/ml.
authors.affiliation: a Pharmaceutical Institute, Nanjing University of Chinese Medicine , Nanjing 210046 , P.R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Miao
authors.affiliation: b Hanlin College, Nanjing University of Chinese Medicine , Taizhou 225300 , P.R. China.
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.affiliation: a Pharmaceutical Institute, Nanjing University of Chinese Medicine , Nanjing 210046 , P.R. China.
authors.forename: F
authors.initials: F
authors.lastname: Yuan
authors.affiliation: a Pharmaceutical Institute, Nanjing University of Chinese Medicine , Nanjing 210046 , P.R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.affiliation: a Pharmaceutical Institute, Nanjing University of Chinese Medicine , Nanjing 210046 , P.R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a Pharmaceutical Institute, Nanjing University of Chinese Medicine , Nanjing 210046 , P.R. China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Pharmaceutical Institute, Nanjing University of Chinese Medicine , Nanjing 210046 , P.R. China.
authors.forename: X
authors.initials: X
authors.lastname: Li
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D031041:Annona / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005663:Furans / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007783:Lactones; D010936:Plant Extracts; C059660:squamocin
keywords: HPLC; NMR; annonaceous acetogenins; anti-tumour