title: Acute myeloid leukemia developing in a granulocyte colony-stimulating factor-mobilized stem cell donor: A case report and review of the literature.
abstract: We describe the first case of a FLT-3 mutated AML in a healthy donor, 3years after recombinant human granulocyte colony stimulating factor (rhG-CSF)-mobilized peripheral blood stem cell (PBSC) harvest. The patient had a myeloablative (MA) matched unrelated donor (MUD) stem cell transplant (SCT) for refractory AML. However, he experienced a secondary graft failure. He had a second non myeloablative (NMA) on day +75 from a second MUD. He achieved a complete neutrophil and platelet engraftment. After 4years of follow up, he is alive in complete remission with full second donor chimerism.
authors.affiliation: Staten Island University Hospital, Staten Island, NY 10305, USA.
authors.forename: Housam
authors.initials: H
authors.lastname: Haddad
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
authors.forename: Manida
authors.initials: M
authors.lastname: Wungjiranirun
authors.affiliation: Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: Usg2001@med.cornell.edu.
authors.forename: Usama
authors.initials: U
authors.lastname: Gergis
mesh_terms: D000328:Adult; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D014019:Tissue Donors
chemical_list: D016179:Granulocyte Colony-Stimulating Factor
keywords: Filgrastim; Peripheral blood stem cell; Recombinant human granulocyte colony-stimulating factor; Stem cell donor