title: Long non-coding RNA and chromatin remodeling.
abstract: Long noncoding RNAs (lncRNAs) are pivotal regulators of genome structure and gene expression. LncRNAs can directly interact with chromatin-modifying enzymes and nucleosome-remodeling factors to control chromatin structure and accessibility of genetic information. Moreover, lncRNA expression can be controlled by chromatin-remodeling factors, suggesting a feedback circuit of regulation. Here, we discuss the recent advances of lncRNA studies, focusing on the function and mechanism of lncRNA-chromatin interactions.
authors.affiliation: a Krannert Institute of Cardiology and Division of Cardiology ; Department of Medicine; Indiana University School of Medicine ; Indianapolis , IN USA.|b Division of Cardiovascular Medicine; Stanford University School of Medicine ; Stanford , CA USA.
authors.forename: Pei
authors.initials: P
authors.lastname: Han
authors.affiliation: a Krannert Institute of Cardiology and Division of Cardiology ; Department of Medicine; Indiana University School of Medicine ; Indianapolis , IN USA.|c Department of Biochemistry and Molecular Biology ; Indiana University School of Medicine ; Indianapolis , IN USA.|d Department of Medical and Molecular Genetics ; Indiana University School of Medicine ; Indianapolis , IN USA.
authors.forename: Ching-Pin
authors.initials: CP
authors.lastname: Chang
mesh_terms: D002843:Chromatin / Q000235:genetics; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D005786:Gene Expression Regulation; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000628:therapy*; D006801:Humans; D012313:RNA / Q000235:genetics / Q000627:therapeutic use; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000627:therapeutic use
chemical_list: D002843:Chromatin; D062085:RNA, Long Noncoding; D012313:RNA
keywords: RNA therapeutics; chromatin modification; chromatin remodeling; human diseases; lncRNA promoter; lncRNA regulation; long non-coding RNA