title: Melanoma in situ: Part II. Histopathology, treatment, and clinical management.
abstract: Melanoma in situ (MIS) poses special challenges with regard to histopathology, treatment, and clinical management. The negligible mortality and normal life expectancy associated with patients with MIS should guide treatment for this tumor. Similarly, the approach to treatment should take into account the potential for MIS to transform into invasive melanoma, which has a significant impact on morbidity and mortality. Part II of this continuing medical education article reviews the histologic features, treatment, and management of MIS.
authors.affiliation: Department of Dermatology, Brown University School of Medicine, Providence, Rhode Island. Electronic address: higgi125@gmail.com.
authors.forename: H William
authors.initials: HW
authors.lastname: Higgins
authors.affiliation: Department of Dermatology, Brown University School of Medicine, Providence, Rhode Island.
authors.forename: Kachiu C
authors.initials: KC
authors.lastname: Lee
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Anjela
authors.initials: A
authors.lastname: Galan
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: David J
authors.initials: DJ
authors.lastname: Leffell
mesh_terms: D000287:Administration, Topical; D000634:Aminoquinolines / Q000627:therapeutic use; D001707:Biopsy, Needle; D002278:Carcinoma in Situ / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D000077271:Imiquimod; D007150:Immunohistochemistry; D007167:Immunotherapy / Q000379:methods; D015552:Injections, Intralesional; D016898:Interferon-alpha / Q000008:administration & dosage; D053685:Laser Therapy / Q000379:methods; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000628:therapy*; D015580:Mohs Surgery / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome; D000096142:Cutaneous Malignant Melanoma
chemical_list: D000634:Aminoquinolines; D016898:Interferon-alpha; D000077271:Imiquimod
keywords: lentigo maligna; melanoma; melanoma in situ