title: Experimental and numerical measurements of adhesion energies between PHEMA and PGLYMA with hydroxyapatite crystal.
abstract: Synthetic orthopaedic materials consisting of a single bioinert polymeric material do not meet the complex biological and physical requirements of scaffold-guided bone tissue repair and regeneration. Of particular interest is the design of biocompatible hydrogel-hydroxyapatite composite bone substitutes with outstanding interfacial adhesion that would warranty the ability for the composite to withstand functional loadings without exhibiting brittle fractures during the dynamic guided tissue regeneration. For this purpose, the hydroxylated side chain of chemically cross-linked poly (2-hydroxyethyl methacrylate) (pHEMA) is substitute with a carboxylated side chain to make poly (glycerol methacrylate) (pGLYMA). Here, we carry out atomistic simulations and atomic force microscopy to predict and experimentally determine the interfacial adhesion energies of pHEMA and pGLYMA with the surface of single-crystalline hydroxyapatite (HA) whiskers. Both experimental and numerical results showed that pGLYMA has stronger adhesion forces with HA and may be used for preparing a high-affinity polymer-HA composite. The high adhesive interactions between pGLYMA and HA were found to be due to strong electrostatic energies.
authors.affiliation: Department of Mechanical Engineering, Worcester Polytechnic Institute, 100 Institute Rd, Worcester, MA 01609, USA.
authors.forename: Sina
authors.initials: S
authors.lastname: Youssefian
authors.forename: Pingsheng
authors.initials: P
authors.lastname: Liu
authors.forename: Sina
authors.initials: S
authors.lastname: Askarinejad
authors.forename: Faezeh
authors.initials: F
authors.lastname: Shalchy
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.forename: Nima
authors.initials: N
authors.lastname: Rahbar
mesh_terms: D000268:Adhesiveness; D018786:Bone Substitutes / Q000138:chemical synthesis*; D003198:Computer Simulation; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry*; D004735:Energy Transfer; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D008956:Models, Chemical; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D008689:Methacrylates; C513219:poly(glycerol dimethacrylate); D011102:Polyhydroxyethyl Methacrylate; D017886:Durapatite