title: eHSP70/iHSP70 and divergent functions on the challenge: effect of exercise and tissue specificity in response to stress.
abstract: Heat-shock proteins including HSP70 are stress-related proteins that have been reported in cell protection and survival. In contrast to this, the increase in circulating levels of HSP70 (eHSP70) is associated with cellular damage and inflammatory factors. Physical stress, like exercise, is effective to induce both iHSP70 and eHSP70 in several tissues and cell types, which have different behaviours in response to stress. The different functions of HSP70 before the challenge are dependent of intracellular localization and subsequent molecular chaperone action, but when present in the extracellular space, it activates pro-inflammatory pathways. The different forms in which tissues and cells respond to stress like physical exercise, as well as the optimal intensity of the stress, are determinants for the beneficial effects or as an indicator of dangerous conditions, summoning immune cells as a warning sign to the body.
authors.affiliation: Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Bittencourt
authors.affiliation: Department of Neuroscience, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Rossana Rosa
authors.initials: RR
authors.lastname: Porto
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000378:metabolism*; D015398:Signal Transduction; D013312:Stress, Physiological; D015854:Up-Regulation
chemical_list: D018840:HSP70 Heat-Shock Proteins
keywords: cellular stress; extracellular HSP70; intracellular HSP70; physical exercise; tissue response