title: Investigation into the role of catabolite control protein A in the metabolic regulation ofStreptococcus suisserotype 2 using gene expression profile analysis.
abstract: Catabolite control protein A (CcpA) serves a key function in the catabolism ofStreptococcus suisserotype 2 (S. suis 2) by affecting the biological function and metabolic regulatory mechanisms of this bacterium. The aim of the present study was to identify variations in CcpA expression inS. suis 2using gene expression profile analysis. Using sequencing and functional analysis, CcpA was demonstrated to play a regulatory role in the expression and regulation of virulence genes, carbon metabolism and immunoregulation inS. suis 2. Gene Ontology and Kyto Encyclopedia of Genes and Genomes analyses indicated that CcpA inS. suis 2is involved in the regulation of multiple metabolic processes. Furthermore, combined analysis of the transcriptome and metabolite data suggested that metabolites varied due to the modulation of gene expression levels under the influence of CcpA regulation. In addition, metabolic network analysis indicated that CcpA impacted carbon metabolism to a certain extent. Therefore, the present study has provided a more comprehensive analysis of the role of CcpA in the metabolic regulation ofS. suis 2, which may facilitate future investigation into this mechanism. Furthermore, the results of the present study provide a foundation for further research into the regulatory function of CcpA and associated metabolic pathways inS. suis 2.
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors.forename: Xulong
authors.initials: X
authors.lastname: Lang
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors.forename: Zhonghai
authors.initials: Z
authors.lastname: Wan
authors.affiliation: Changchun Stomatological Hospital, Changchun, Jilin 130042, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Pan
authors.affiliation: School of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.
authors.forename: Xiuran
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Bu
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qian
authors.affiliation: Shanghai Sensichip Infotech Co. Ltd., Shanghai 200433, P.R. China.
authors.forename: Huazong
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors.forename: Xinglong
authors.initials: X
authors.lastname: Wang
keywords: Streptococcus suis serotype 2; catabolite control protein A; gene expression profile; metabolic regulation