title: Depside derivatives with anti-hepatic fibrosis and anti-diabetic activities from Impatiens balsamina L. flowers.
abstract: Eighteen compounds (1-18), seven new (3-9) and eleven previously reported (1, 2, and 10-18), were isolated from the flowers of Impatiens balsamina (Linn). The structures of the isolated compounds were elucidated using different spectroscopic methods, including NMR (1D and 2D), UV, IR, and HR-ESI-MS. Analysis of the bioassay results showed the compounds had notable anti-hepatic fibrosis activity against murine Hepatic Stellate Cells (t-HSC/Cl-6) and anti-diabetics activity against α-glucosidase. Specifically, new compounds 7, 8, 9 showed significant inhibitory activity on t-HSC/Cl-6 cells with IC50 values of 42.12, 109.2, and 34.04 μg/mL respectively, while the IC50 values of positive control Silymarin and Fufang Biejia Ruangan Pian were 202.34 and 231.56 μg/mL, respectively. In addition, compounds 2, 4, 7, 8, 10, 11, 17, and 18 exhibited excellent α-glucosidase inhibitory activity. Among these compounds, 7 exhibited the highest activity with an IC50 value of 0.72 μg/mL, while the IC50 value of the positive control acarbose was 3.36 μg/mL. This is the first study evaluating the anti-hepatic fibrosis and anti-diabetic activities of compounds isolated from the flowers of I. balsamina.
authors.affiliation: Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Xiaoshu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yuntian
authors.initials: Y
authors.lastname: Lou
authors.affiliation: Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Ding
authors.affiliation: Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: yqz2016@163.com.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D053630:Depsides / Q000302:isolation & purification / Q000494:pharmacology*; D003920:Diabetes Mellitus; D035264:Flowers / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D055166:Hepatic Stellate Cells / Q000187:drug effects*; D029069:Impatiens / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008103:Liver Cirrhosis; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D053630:Depsides; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts
keywords: Anti-diabetic activity; Anti-hepatic fibrosis; Impatiens balsamina L