title: Targeting the gastrointestinal tract to develop novel therapies for HIV.
abstract: Despite the use of antiretroviral therapy (ART), which delays and/or prevents AIDS pathogenesis, human immunodeficiency virus (HIV)-infected individuals continue to face increased morbidities and mortality rates compared with uninfected individuals. Gastrointestinal (GI) mucosal dysfunction is a key feature of HIV infection, and is associated with mortality. In this study, we review current knowledge about mucosal dysfunction in HIV infection, and describe potential avenues for therapeutic targets to enhance mucosal function and decrease morbidities and mortalities in HIV-infected individuals.
authors.affiliation: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Reeves
authors.affiliation: National Laboratory for HIV Immunology, Public Health Agency of Canada, Winnipeg, Canada.|Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.|Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Burgener
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.|Washington National Primate Research Center, Seattle, Washington, USA.
authors.forename: N R
authors.initials: NR
authors.lastname: Klatt
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015195:Drug Design; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000276:immunology / Q000821:virology; D006678:HIV / Q000187:drug effects* / Q000276:immunology / Q000472:pathogenicity; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D058990:Molecular Targeted Therapy; D009092:Mucous Membrane / Q000187:drug effects / Q000276:immunology / Q000821:virology
chemical_list: D019380:Anti-HIV Agents