title: Some reminiscences on studies of age-dependent and activity-dependent degeneration of sensory and motor endings in mammalian skeletal muscle.
abstract: I present here an overview of research on the biology of neuromuscular sensory and motor endings that was inspired and influenced partly by my educational experience in the Department of Zoology at the University of Durham, from 1971 to 1974. I allude briefly to neuromuscular synaptic structure and function in dystrophic mice, influences of activity on synapse elimination in development and regeneration, and activity-dependent protection and degeneration of neuromuscular junctions in Wld(S) mice.
authors.affiliation: Euan MacDonald Centre for Motor Neurone Disease Research and Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh, UK.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Ribchester
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal; D009410:Nerve Degeneration / Q000503:physiopathology*; D009469:Neuromuscular Junction / Q000033:anatomy & histology / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology*
keywords: muscle spindle; neuromuscular junction; neuroprotection