title: Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases.
abstract: Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration (AMD), and Alzheimer's disease (AD). In aging cells, the natural antioxidant capacity decreases and the overall efficiency of reparative systems against cell damage becomes impaired. There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases. This review highlights recent data helping to clarify the molecular mechanisms involved in the stilbene-mediated protection against oxidative stress. The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized. The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.
authors.affiliation: Department of Ophthalmology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Reinisalo
authors.affiliation: Department of Biology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Kårlund
authors.affiliation: Department of Ophthalmology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland ; Department of Biology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
authors.forename: Ali
authors.initials: A
authors.lastname: Koskela
authors.affiliation: Department of Ophthalmology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland ; Department of Ophthalmology, Kuopio University Hospital, P.O. Box 1627, 70211 Kuopio, Finland.
authors.forename: Kai
authors.initials: K
authors.lastname: Kaarniranta
authors.affiliation: Department of Biology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
authors.forename: Reijo O
authors.initials: RO
authors.lastname: Karjalainen
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051267:NF-E2-Related Factor 2; D059808:Polyphenols; D017382:Reactive Oxygen Species; D013267:Stilbenes