title: Regioselective functionalisation of dibenzothiophenes through gold-catalysed intermolecular alkyne oxyarylation.
abstract: A protocol has been developed for direct Csp(3)-Csp(2) bond formation at the 4- and 6-positions of dibenzothiophenes using a gold(I) catalyst with terminal alkynes and dibenzothiophene-S-oxides. The sulfoxide acts as a traceless directing group to avoid the need to prefunctionalise at carbon. The iterative use of this protocol is possible and has been employed in the preparation of novel macrocyclic structures. In addition, a cascade process shows how oxyarylations can be combined with other processes resulting in complex, highly efficient transformations.
authors.affiliation: School of Chemistry, University of Birmingham, Haworth Building, Edgbaston, Birmingham, B15 2TT, UK. p.w.davies@bham.ac.uk r.s.grainger@bham.ac.uk.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Barrett
authors.forename: Paul W
authors.initials: PW
authors.lastname: Davies
authors.forename: Richard S
authors.initials: RS
authors.lastname: Grainger