title: Activity intensity, assistive devices and joint replacement influence predicted remodelling in the proximal femur.
abstract: Bone morphology and density changes are commonly observed following joint replacement, may contribute to the risks of implant loosening and periprosthetic fracture and reduce the available bone stock for revision surgery. This study was presented in the 'Bone and Cartilage Mechanobiology across the scales' WCCM symposium to review the development of remodelling prediction methods and to demonstrate simulation of adaptive bone remodelling around hip replacement femoral components, incorporating intrinsic (prosthesis) and extrinsic (activity and loading) factors. An iterative bone remodelling process was applied to finite element models of a femur implanted with a cementless total hip replacement (THR) and a hip resurfacing implant. Previously developed for a cemented THR implant, this modified process enabled the influence of pre- to post-operative changes in patient activity and joint loading to be evaluated. A control algorithm used identical pre- and post-operative conditions, and the predicted extents and temporal trends of remodelling were measured by generating virtual X-rays and DXA scans. The modified process improved qualitative and quantitative remodelling predictions for both the cementless THR and resurfacing implants, but demonstrated the sensitivity to DXA scan region definition and appropriate implant-bone position and sizing. Predicted remodelling in the intact femur in response to changed activity and loading demonstrated that in this simplified model, although the influence of the extrinsic effects were important, the mechanics of implantation were dominant. This study supports the application of predictive bone remodelling as one element in the range of physical and computational studies, which should be conducted in the preclinical evaluation of new prostheses.
authors.affiliation: Bioengineering Science Research Group, University of Southampton, Mailpoint M7, Highfield, Southampton, SO17 1BJ, UK. alex.dickinson@soton.ac.uk.
authors.forename: A S
authors.identifier: http://orcid.org/0000-0002-9647-1944
authors.initials: AS
authors.lastname: Dickinson
mesh_terms: D015502:Absorptiometry, Photon; D019644:Arthroplasty, Replacement, Hip; D001843:Bone Cements / Q000494:pharmacology; D015519:Bone Density / Q000187:drug effects; D016723:Bone Remodeling; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D020342:Finite Element Analysis; D006622:Hip Prosthesis; D006801:Humans; D016474:Weight-Bearing / Q000502:physiology
chemical_list: D001843:Bone Cements
keywords: FE analysis; Hip resurfacing; Predicted bone remodelling; Total hip replacement