title: Secondary metabolites from the root of Lindera reflexa Hemsl.
abstract: Fourteen compounds were isolated from the root of Lindera reflexa Hemsl. Among these compounds, reflexan A (compound 1) was discovered to possess a novel skeleton and two stilbenes (compounds 2 and 3) were newly discovered compounds. Eleven known compounds (4-14) were also isolated, which included three alkaloids, one coumarin, four stilbenes, two flavonoids and katsumadain. The unusual structure of compounds 1, 2 and 3, along with their absolute configurations, was determined from UV, IR, HR ESI-MS, and 1D and 2D NMR data and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. All of the isolates were tested with antitumor and anti-inflammatory assays. The results revealed that compounds 1, 2, and 3 all showed inhibitory activity toward three tumor cell lines, A549 (human lung carcinoma), BEL-7402 (human liver carcinoma) and HCT-8 (human colon carcinoma). None of the compounds exhibited anti-inflammatory activity.
authors.affiliation: School of Pharmacy, Henan University of Traditional Chinese Medicine, BoXue Road, Jinshui District, ZhengZhou, 450046, China. Electronic address: suiqingchen@163.com.
authors.forename: Suiqing
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Henan University of Traditional Chinese Medicine, BoXue Road, Jinshui District, ZhengZhou, 450046, China. Electronic address: wllywlly2004@163.com.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Henan University of Traditional Chinese Medicine, BoXue Road, Jinshui District, ZhengZhou, 450046, China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Henan University of Traditional Chinese Medicine, BoXue Road, Jinshui District, ZhengZhou, 450046, China.
authors.forename: Yalei
authors.initials: Y
authors.lastname: Wei
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D027443:Lindera / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D064210:Secondary Metabolism; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010936:Plant Extracts; D013267:Stilbenes
keywords: Antitumor; Lindera reflexa Hemsl; New skeleton; Stilbene