title: Prenatal Exposure to Polybrominated Flame Retardants and Fetal Growth in the INMA Cohort (Spain).
abstract: Our aim was to investigate the relation between PBDEs and fetal growth or newborn anthropometry in a Spanish cohort (2003-2008). PBDE congeners (BDE-47, -99, -153, -154, and -209) were determined in serum of 670 mothers at gestational week 12 and in 534 umbilical cord samples. Abdominal circumference (AC), estimated fetal weight (EFW), femur length (FL), and biparietal diameter (BPD) during gestation were measured by ultrasounds. At birth, weight (BW), head circumference (HC), and length (BL) were also measured. We assessed growth in the intervals between 12-20 and 20-34 weeks of gestation and size at birth by standard deviation (SD)-scores adjusted for constitutional characteristics. We conducted multivariate linear regression analyses between PBDE congeners and their sum (ΣPBDEs) and outcomes. We found statistically significant inverse associations between ΣPBDEs and AC, EFW, and BPD at weeks 20-34 and HC at birth. Regarding congeners, the association was clearer with BDE-99, with inverse associations being found with AC, EFW, and BPD at weeks 20-34, and with BW and HC at delivery. These outcomes decreased between 1.3% and 3.5% for each 2-fold PBDE increase. Concerning matrices, we found statistically significant inverse associations with BPD, HC, and BW when using maternal serum, and for AC and EFW with cord serum. In conclusion, PBDEs may impair fetal growth in late pregnancy and reduce birth size.
authors.affiliation: †FISABIO-Universitat Jaume I-Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Avenida de Catalunya 21, 46020 Valencia, Spain.|‡Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
authors.forename: Maria-Jose
authors.initials: MJ
authors.lastname: Lopez-Espinosa
authors.affiliation: †FISABIO-Universitat Jaume I-Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Avenida de Catalunya 21, 46020 Valencia, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Costa
authors.affiliation: §Department of Preventive Medicine and Public Health, University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Asturias, Spain.|∥Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Jordi Girona, 18, 08034 Barcelona, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Vizcaino
authors.affiliation: †FISABIO-Universitat Jaume I-Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Avenida de Catalunya 21, 46020 Valencia, Spain.|‡Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Murcia
authors.affiliation: ‡Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.|§Department of Preventive Medicine and Public Health, University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Asturias, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Fernandez-Somoano
authors.affiliation: †FISABIO-Universitat Jaume I-Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Avenida de Catalunya 21, 46020 Valencia, Spain.|‡Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Iñiguez
authors.affiliation: †FISABIO-Universitat Jaume I-Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Avenida de Catalunya 21, 46020 Valencia, Spain.|‡Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Llop
authors.affiliation: ∥Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Jordi Girona, 18, 08034 Barcelona, Spain.
authors.forename: Joan O
authors.initials: JO
authors.lastname: Grimalt
authors.affiliation: †FISABIO-Universitat Jaume I-Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Avenida de Catalunya 21, 46020 Valencia, Spain.|‡Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.
authors.forename: Ferran
authors.initials: F
authors.lastname: Ballester
authors.affiliation: ‡Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Calle Monforte de Lemos 3-5, 28029 Madrid, Spain.|§Department of Preventive Medicine and Public Health, University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Asturias, Spain.
authors.forename: Adonina
authors.initials: A
authors.lastname: Tardon
mesh_terms: D000328:Adult; D049628:Body Size; D001835:Body Weight; D015331:Cohort Studies; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005411:Flame Retardants / Q000009:adverse effects*; D055768:Halogenated Diphenyl Ethers / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D013030:Spain; D016216:Ultrasonography, Prenatal
chemical_list: D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers