title: [The effect of genetic risk of diabetes on the correlations in bone and energy homeostasis].
abstract: BACKGROUND
  Type 2 diabetes is associated with increased risk of bone fractures, and the connection between bone remodeling and carbohydrate homeostasis is decoupled. It is not known whether these phenomena are the consequence of the deteriorating glucose metabolism, and the increasing insulin resistance or they belong to the genetic risk of type 2 diabetes.
  
  
  OBJECTIVE
  The aim of the authors was to clarify the impact of genetic risk on bone and carbohydrate homeostasis connections.
  
  
  METHODS
  Hyperinsulinemic-normoglycemic clamps, and oral and iv. glucose loads were done to select 18 metabolically healthy females with first degree type 2 diabetic relatives -and 26 without diabetic relatives.
  
  
  RESULTS
  The connections between total body glucose utilization and the activity of the bone metabolic unit were missing in healthy females with the genetic risk of type 2 diabetes, like in those with manifest diabetes. In this risk group the level of low-density-large molecular sized LDL lipids were decreased, while the high-density LDL group with low molecular size was increased. The latter change was in significant connection with increased interleukin-6 levels and increased bone resorption within the bone metabolic unit.
  
  
  CONCLUSIONS
  These data suggest that the missing connection between glucose and bone metabolism is not the consequence of the developing insulin resistance and deteriorating glucose metabolism, but rather it belongs to the inherited diabetes risk. The etiology of this early alteration, which develops prior to glucose intolerance and insulin resistance is unknown and needs further investigations.
authors.affiliation: Therapiezentrum Wolkersdorf Schwabach, Németország.
authors.forename: Attila
authors.initials: A
authors.lastname: Fék
authors.forename: Barbara
authors.initials: B
authors.lastname: Buday
authors.forename: Györgyi
authors.initials: G
authors.lastname: Kovács
authors.forename: Márta
authors.initials: M
authors.lastname: Vitai
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Vecsei
authors.forename: József
authors.initials: J
authors.lastname: Pauer
authors.forename: Botond
authors.initials: B
authors.lastname: Literáti-Nagy
authors.forename: Katalin
authors.initials: K
authors.lastname: Bezzegh
authors.forename: Éva
authors.initials: É
authors.lastname: Péterfai
authors.forename: László
authors.initials: L
authors.lastname: Korányi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin
keywords: 2-es típusú diabetes mellitus; bone metabolism; csontanyagcsere; genetic risk; genetikai kockázat; lipidek; lipids; type 2 diabetes