title: Serum paraoxonase activity is associated with epicardial fat tissue in renal transplant recipients.
abstract: OBJECTIVE
  Cardiovascular disease is a major cause of mortality in renal transplant recipients. Paraoxonase-1 (PON-1) has been shown to protect against atherosclerosis by modifying lipoproteins. Epicardial fat tissue (EFT) has been proposed as a new cardiovascular risk factor. The aim of this study was to investigate the relationship between PON-1 activity and EFT in renal transplant recipients.
  
  
  METHODS
  Eighty renal transplant recipients were enrolled in this cross-sectional study. PON-1 activity was assessed from the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. EFT was measured by echocardiography.
  
  
  RESULTS
  The mean age of the patients was 40.4 ± 12.3 years and mean post transplant follow-up duration was 57.2 ± 46 months. Mean PON-1 activity was 68.5 ± 30 U/L. PON-1 activity was positively correlated with age and body mass index and negatively correlated with parathyroid hormone, dialysis duration and EFT. The mean EFT thickness was 0.64 ± 0.17 cm. Multiple linear regression analysis was used to define independent determinants of EFT in renal transplant recipients. According to linear regression analysis, PON-1 levels and age were found to be independent predictors of EFT.
  
  
  CONCLUSIONS
  Reduced PON-1 activity was negatively associated with EFT and PON-1 activity independently predicts EFT in renal transplant recipients.
authors.affiliation: Department of Internal Medicine, Erciyes University Medical School, Kayseri, Turkey, drerayeroglu@hotmail.com.
authors.forename: Eray
authors.initials: E
authors.lastname: Eroglu
authors.forename: Ismail
authors.initials: I
authors.lastname: Kocyigit
authors.forename: Aydin
authors.initials: A
authors.lastname: Unal
authors.forename: Hafsa
authors.initials: H
authors.lastname: Korkar
authors.forename: Cigdem
authors.initials: C
authors.lastname: Karakukcu
authors.forename: Ozcan
authors.initials: O
authors.lastname: Orscelik
authors.forename: Murat Hayri
authors.initials: MH
authors.lastname: Sipahioglu
authors.forename: Bulent
authors.initials: B
authors.lastname: Tokgoz
authors.forename: Oktay
authors.initials: O
authors.lastname: Oymak
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D010496:Pericardium / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D012307:Risk Factors; D066027:Transplant Recipients
chemical_list: D043303:Aryldialkylphosphatase