title: Comparison of selective head cooling versus whole-body cooling.
abstract: BACKGROUND
  This study compared selective head cooling (SHC) and whole-body cooling (WBC) in newborns with hypoxic-ischemic encephalopathy (HIE).
  
  
  METHODS
  We conducted a prospective randomized small-scale pilot study in newborns with HIE, born after >35 weeks of gestation. The patients were randomly assigned to receive SHC or WBC.
  
  
  RESULTS
  The SHC group consisted of 17 patients, and the WBC group, 12 patients. There was no significant difference in adverse effects related to cooling therapy between the two groups. During the 12 month study period, seven patients in the SHC group and four in the WBC group died, but the difference was not significant (P = 0.667). Among the patients alive at 12 months after treatment, six in the SHC group and four in the WBC group had severe disabilities; the difference was not significant (P = 0.671). When the composite outcome of death or severe disability was evaluated, the difference between the SHC group (77%, n = 13) and the WBC group (67%, n = 8) was not significant (P = 0.562). Moreover, the number of survivors without disability at 12 months after treatment did not differ significantly between the SHC group (n = 3) and the WBC group (n = 4; P = 0.614).
  
  
  CONCLUSIONS
  There were no significant differences in adverse effects, 12 month neuromotor development, or mortality rate between SHC and WBC in newborns with HIE, born after >35 weeks of gestation.
authors.affiliation: Division of Neonatology, Department of Pediatrics, School of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Yalcın
authors.initials: Y
authors.lastname: Celik
authors.affiliation: Division of Neonatology, Department of Pediatrics, School of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Aytug
authors.initials: A
authors.lastname: Atıcı
authors.affiliation: Division of Neonatology, Department of Pediatrics, School of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Selvi
authors.initials: S
authors.lastname: Gulası
authors.affiliation: Department of Pediatric Neurology, School of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Okuyaz
authors.affiliation: Department of Pediatric Neurology, School of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Khatuna
authors.initials: K
authors.lastname: Makharoblıdze
authors.affiliation: Department of Biostatistics, School of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Sungur
mesh_terms: D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: hypoxic-ischemic encephalopathy; newborn; selective head cooling; whole-body cooling