title: Maternal serum concentrations of s-Endoglin and IL-6 in pregnancy complicated by preterm premature membrane rupture.
abstract: OBJECTIVE
  This study aimed to investigate maternal serum concentrations of s-Endoglin and compare s-Endoglin with other inflammatory markers in prediction of time to delivery, in pregnancies complicated by preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  Fifty five patients complicated by PPROM whose gestational age were between 2433 weeks and 44 matched healthy pregnant women were included in present study. Maternal concentrations of s-Endoglin concentrations were measured by an enzyme-linked immunosorbent assay (ELISA) and compared with maternal inflammatory markers including interleukin-6 (IL-6), white blood cell (WBC) count and serum C-reactive protein (CRP). The best variable for prediction of preterm birth was computed.
  
  
  RESULTS
  Mean s-Endoglin levels in PPROM were lower than control groups (0.24 ± 0.12 pg/ml and 0.69 ± 0.25 pg/ml, respectively, p < 0.01). Besides IL-6 (p < 0.01), WBC (p = 0.016) and CRP (p = 0.010) levels were higher in PPROM group. In PPROM group, ROC analysis results of s-Endoglin for prediction of preterm delivery <48 h, <7 days, <32 weeks were not different (p > 0.05). For predicting preterm birth before 48 h and 7 days, only IL-6 at cut off value >0.70 (pg/ml) and >0.55 (pg/ml) had area under curve (AUC); 0.871 (0.7750.965), p < 0.01, AUC; 0.925 (0.8560.993), p < 0.001, respectively.
  
  
  CONCLUSIONS
  s-Endoglin as an anti-angiogenic marker seemed to have a role in pathogenesis but results of present study showed that, unlike IL-6, it was unsatisfactory for estimating time to delivery in PPROM.
authors.affiliation: a Department of Obstetrics & Gynecology, Faculty of Medicine , Adnan Menderes University , Aydın , Turkey .
authors.forename: Sümeyra
authors.initials: S
authors.lastname: Nergiz Avcıoğlu
authors.affiliation: a Department of Obstetrics & Gynecology, Faculty of Medicine , Adnan Menderes University , Aydın , Turkey .
authors.forename: Selda
authors.initials: S
authors.lastname: Demircan Sezer
authors.affiliation: b Department of Obstetrics & Gynecology, Faculty of Medicine , Muğla Sıtkı Koçman University , Muğla , Turkey .
authors.forename: Mert
authors.initials: M
authors.lastname: Küçük
authors.affiliation: a Department of Obstetrics & Gynecology, Faculty of Medicine , Adnan Menderes University , Aydın , Turkey .
authors.forename: Emre
authors.initials: E
authors.lastname: Zafer
authors.affiliation: a Department of Obstetrics & Gynecology, Faculty of Medicine , Adnan Menderes University , Aydın , Turkey .
authors.forename: Hasan
authors.initials: H
authors.lastname: Yüksel
authors.affiliation: c Department of Neonatology, Faculty of Medicine , Adnan Menderes University , Aydın , Turkey , and.
authors.forename: Barıs
authors.initials: B
authors.lastname: Akcan
authors.affiliation: d Obstetric and Gynecology Clinic, Iskenderun State Hospital , Hatay Merkez/Hatay , Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Turgut
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D000071063:Endoglin / Q000097:blood*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007958:Leukocyte Count; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers; C064206:ENG protein, human; D000071063:Endoglin; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein
keywords: IL-6; preterm premature membranes rupture; s-Endoglin; time to delivery interval