title: Drug-coated balloons--the importance of packing and dosing antiproliferative drugs.
abstract: Several balloon catheters coated with paclitaxel have been shown to reduce restenosis rates in the superficial femoral artery (SFA) revealing a relatively wide therapeutic window of effective doses ranging from 2 to 3 µg/mm(2) balloon surface area. Delivering lower antiproliferative drug doses to the vessel wall may not be inferior to higher drug doses provided that effective drug-excipient formulations have been chosen. Leaving non-flow limiting dissection in the SFA non-stented might be an option after use of drug-coated balloons.
authors.affiliation: Department of Cardiolgy and Angiology I, University Heart Center, Freiburg- Bad Krozingen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Hehrlein
mesh_terms: D000800:Angioplasty, Balloon / Q000295:instrumentation*; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible; D005260:Female; D005263:Femoral Artery; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D058729:Peripheral Arterial Disease / Q000628:therapy*; D011150:Popliteal Artery; D062666:Vascular Access Devices
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible; D017239:Paclitaxel