title: A Fatal Case of Endocarditis on CoreValve ReValving System Caused by Enterococcus faecium Complicated by Iatrogenic Pancytopenia and Subacute Disseminated Intravascular Coagulation.
abstract: During the past few years, a new and attractive approach--transcatheter aortic valve implantation (TAVI)--has been developed for patients who are symptomatic of aortic stenosis and, due to the high expected operative risk, would not be otherwise treated. Unfortunately, TAVI can result in endocarditis of the percutaneously implanted valve that may present atypically and cause delays in diagnosis and treatment. Herein, the case is described of a 79-year-old female affected by endocarditis on aortic valve percutaneously implanted caused by Enterococcus faecium, complicated by iatrogenic pancytopenia and subacute disseminated intravascular coagulation, that proved fatal at six months after TAVI.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cimmino
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ciccarelli
authors.forename: Marco
authors.initials: M
authors.lastname: Golino
authors.forename: Chiara
authors.initials: C
authors.lastname: D'Amico
authors.forename: Paolo
authors.initials: P
authors.lastname: Golino
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000382:microbiology*; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016984:Enterococcus faecium / Q000302:isolation & purification*; D017707:Erythrocyte Transfusion; D017809:Fatal Outcome; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007049:Iatrogenic Disease; D010198:Pancytopenia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D013997:Time Factors; D017211:Treatment Failure; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants