title: Basophilia and megakaryoblastic differentiation in a case of acute myeloid leukemia: An unusual morphological combination.
abstract: Basophilia is commonly associated with chronic myelogenous leukemia, notably in the accelerated phase or during blast crisis. It is also associated with other myeloproliferative neoplasms. However, its association with acute leukemia is very rare and is described in association with acute basophilic leukemia and few acute myeloid leukemias (AMLs) with recurrent genetic abnormalities such as t(6;9)(p23;q34). Herein, we describe the morphological features and discuss the differential diagnosis of a case of AML with the blasts showing previously unreported unusual combination of megakaryoblastic and basophilic differentiation along with peripheral blood and bone marrow basophilia.
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Sreejesh
authors.initials: S
authors.lastname: Sreedharanunni
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address: nkkalson@yahoo.co.in.
authors.forename: Narender
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Prakash
mesh_terms: D000293:Adolescent; D001491:Basophils / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000473:pathology*; D055016:Megakaryocyte Progenitor Cells / Q000473:pathology*
keywords: Acute myeloid leukemia; Basophilia; Basophilic blasts; Megakaryoblasts