title: Epigenetic inheritance through the female germ-line: The known, the unknown, and the possible.
abstract: Although genetic mutations have long been known to influence gene expression and individual phenotype, studies emerging over the past decade indicate that such changes can also be induced in the absence of alterations in base-sequence. Epigenetically driven changes in gene expression or phenotype, when they are transmitted to succeeding generations, represent an entirely new mechanism that could generate heritable variation in a population. To understand the mechanistic basis of epigenetic inheritance, it is essential to learn how these changes may be transmitted through the germ-line to the next generation. Here, we review the process of female germ cell specification, oocyte growth, and meiotic maturation. We discuss what is known of the activity and role of three principal candidates to transmit epigenetic information--DNA methylation, histone post-translational modifications, and short non-coding RNAs--in the developing oocyte. We then consider intergenerational inheritance and true transgenerational inheritance and, in the case of the latter, compare examples in which insertional mutations have driven the heritable epigenetic phenotype with examples of environmentally induced epigenetic inheritance for which the mechanism remains to be identified.
authors.affiliation: Departments of Obstetrics and Gynecology and Biology, McGill University; Research Institute - McGill University Health Centre, Canada. Electronic address: Hugh.clarke@mcgill.ca.
authors.forename: Hugh J
authors.initials: HJ
authors.lastname: Clarke
authors.affiliation: Departments of Obstetrics and Gynecology and Biology, McGill University; Research Institute - McGill University Health Centre, Canada.
authors.forename: Karl-Frédéric
authors.initials: KF
authors.lastname: Vieux
mesh_terms: D019175:DNA Methylation / Q000235:genetics; D004781:Environmental Exposure / Q000009:adverse effects*; D044127:Epigenesis, Genetic / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics; D009865:Oocytes / Q000166:cytology / Q000254:growth & development*; D009866:Oogenesis / Q000235:genetics*; D011499:Protein Processing, Post-Translational / Q000235:genetics
chemical_list: D006657:Histones; D035683:MicroRNAs
keywords: DNA methylation; Epigenetics; Histones; MicroRNA; Oogenesis; Transgenerational inheritance