title: Glucocorticoids, calcitonin, and osteocalcin cannot differentiate between aggressive and nonaggressive central giant cell lesions of the jaws.
abstract: OBJECTIVE
  To evaluate the expression of glucocorticoid receptor (GR), calcitonin receptor (CTR), and osteocalcin (OC) in aggressive and nonaggressive central giant cell lesions (CGCLs). The numbers of mitotic and multinucleated giant cells were also evaluated.
  
  
  METHODS
  Thirty-one cases of CGCL were submitted for immunohistochemistry. Mitotic figures and multinucleated giant cells were assessed through histochemical analyses.
  
  
  RESULTS
  Positive staining for GR, CTR, and OC was observed in all cases studied. There were no differences between CGCL variants with regard to the expression of GR, CTR, or OC. The aggressive group showed a higher number of multinucleated giant cells compared with the nonaggressive group (P < .05).
  
  
  CONCLUSIONS
  Nonaggressive and aggressive CGCLs cannot be distinguished by OC, CTR, or GR expression, although the number of multinucleated giant cells may help differentiate between CGCL types.
authors.affiliation: Oral Pathology, Universidade Federal de Goiás, Goiânia, Goiâs, Brazil.
authors.forename: Allisson Filipe Lopes
authors.initials: AF
authors.lastname: Martins
authors.affiliation: Oral Pathology, Universidade Federal de Goiás, Goiânia, Goiâs, Brazil.
authors.forename: Paulo Otávio Carmo
authors.initials: PO
authors.lastname: Souza
authors.affiliation: Professor of Oral Radiology, Universidade Paulista (UNIP), Goiânia, Goiâs, Brazil.
authors.forename: Inara Carneiro Costa
authors.initials: IC
authors.lastname: Rege
authors.affiliation: Oral Pathology, Universidade Federal de Goiás, Goiânia, Goiâs, Brazil.
authors.forename: Marília Oliveira
authors.initials: MO
authors.lastname: Morais
authors.affiliation: Oral Pathology, Universidade Federal de Goiás, Goiânia, Goiâs, Brazil. Electronic address: elismaur@ufg.br.
authors.forename: Elismauro Francisco
authors.initials: EF
authors.lastname: Mendonça
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D015675:Osteocalcin / Q000378:metabolism*; D018003:Receptors, Calcitonin / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D018003:Receptors, Calcitonin; D011965:Receptors, Glucocorticoid; D015675:Osteocalcin