title: Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients.
abstract: OBJECTIVE
  Behavioral and psychological symptoms of dementia (BPSD) are common in the clinical manifestation of dementia. Although most patients with dementia exhibit some BPSD during the course of the illness, the association of BPSD with the stage of dementia remains unclear. It was the aim of this study to evaluate the impact of severity of dementia on the expression of BPSD in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD).
  
  
  METHODS
  Ninety-seven patients with DLB and 393 patients with AD were recruited from 8 dementia clinics across Japan. BPSD were assessed by the Neuropsychiatric Inventory (NPI). A relationship between BPSD and dementia stage classified by the Clinical Dementia Rating (CDR) in each type of dementia was assessed.
  
  
  RESULTS
  No significant difference was seen in NPI total score across CDR staging in the DLB group. On the other hand, the NPI total score significantly increased with dementia stage in the AD group.
  
  
  CONCLUSIONS
  The relationship of dementia stage with the expression of BPSD was different according to the type of dementia. BPSD and dementia stage were correlated in AD subjects, in whom psychiatric symptoms increase as the disease progresses, but not in DLB subjects.
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yatabe
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Ishikawa
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan ; Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Tokyo, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Fukuhara
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Kaneda
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Honda
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Yuki
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Division of Speech, Hearing and Cognitive Sciences, Graduate School of Health and Welfare, Niigata University of Health and Welfare, Niigata, Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Imamura
authors.affiliation: Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University, Suita, Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kazui
authors.affiliation: Department of Neuropsychiatry, Kochi Medical School, Nankoku, Tokyo, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kamimura
authors.affiliation: Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Syunichiro
authors.initials: S
authors.lastname: Shinagawa
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Mizukami
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Etsuro
authors.initials: E
authors.lastname: Mori
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Ikeda
keywords: Alzheimer's disease; Dementia with Lewy bodies; Neuropsychiatric symptoms; Severity of dementia