title: The prognostic of p27(kip1) in ovarian cancer: a meta-analysis.
abstract: OBJECTIVE
  P27(kip1) is a negative cell cycle regulator that plays an important role in tumor suppression. Deregulation of p27(kip1) is commonly observed in many human cancers. Numerous studies about p27(kip1) are reported in clinical patients despite variable data for the prognostic of p27(kip1) expression. Here we report a meta-analysis of the association of p27(kip1) expression with the survival of ovarian cancer.
  
  
  METHODS
  PubMed and Web of science were searched for studies evaluating expression of p27(kip1) and prognostic in ovarian cancer. Published data were extracted and computed into odds ratios (ORs) for death at 3 and 5 years. Data were pooled using the random-effect model. All statistical tests were two-sided.
  
  
  RESULTS
  Analysis included 9 studies: six studies were reported in European, three studies were reported in American, and one study was reported in Asian. Loss of p27(kip1) was associated with worse overall survival (OS) at both 3 years [OR = 2.61, 95 % confidence interval (CI) 1.95-3.49, p < 0.05] and 5 years (OR = 3.01, 95 % CI 2.17-4.17, p < 0.05). Among studies with different ethnicity (European, American and Asian), the results showed a more significant association in European, including Italy, Germany, and Greece [for both 3-year OS (OR = 3.53, 95 % CI 2.37-5.26) and 5-year OS (OR = 3.66, 95 % CI 2.30-5.83)].
  
  
  CONCLUSIONS
  Loss of p27(kip1) is associated with worse survival in ovarian cancer. The development of strategies target p27(kip1) could be a reasonable therapeutic approach.
authors.affiliation: Genetic Laboratory, Wuxi Hospital for Maternal and Child Health Care, The Affiliated Hospital of Nanjing Medical University Wuxi, 48 Huaishu-xiang, Wuxi, Jiangsu, 214002, China. lumudan0527@163.com.
authors.forename: Mudan
authors.initials: M
authors.lastname: Lu
authors.affiliation: Genetic Laboratory, Wuxi Hospital for Maternal and Child Health Care, The Affiliated Hospital of Nanjing Medical University Wuxi, 48 Huaishu-xiang, Wuxi, Jiangsu, 214002, China.
authors.forename: You
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Genetic Laboratory, Wuxi Hospital for Maternal and Child Health Care, The Affiliated Hospital of Nanjing Medical University Wuxi, 48 Huaishu-xiang, Wuxi, Jiangsu, 214002, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xu
authors.affiliation: Genetic Laboratory, Wuxi Hospital for Maternal and Child Health Care, The Affiliated Hospital of Nanjing Medical University Wuxi, 48 Huaishu-xiang, Wuxi, Jiangsu, 214002, China.
authors.forename: Jingying
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Genetic Laboratory, Wuxi Hospital for Maternal and Child Health Care, The Affiliated Hospital of Nanjing Medical University Wuxi, 48 Huaishu-xiang, Wuxi, Jiangsu, 214002, China. vase-311@163.com.
authors.forename: Daozhen
authors.initials: D
authors.lastname: Chen
mesh_terms: D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D025521:Tumor Suppressor Proteins
chemical_list: D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27
keywords: Meta-analysis; Ovarian cancer; P27kip1; Prognostic