title: Second messengers, steroids and signaling cascades: Crosstalk in sperm development and function.
abstract: Signaling cascades control numerous aspects of sperm physiology, ranging from creation to fertilization. Novel aspects of several kinases and their influence on sperm development will be discussed in the first section and cover proliferation, chromatin remodeling and morphology. In the second section, protein kinases (A, B and C) that affect sperm function and their regulation by second messengers, cyclic-AMP and phosphoinositides, as well as steroids will be featured. Key areas of integration will be presented on the topics of sperm motility, capacitation, acrosome reaction and fertilization.
authors.affiliation: Endocrine Physiology Laboratory, AVS Department, Clemson University, Clemson, SC, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Lackey
authors.affiliation: Endocrine Physiology Laboratory, AVS Department, Clemson University, Clemson, SC, USA. Electronic address: sngry@clemson.edu.
authors.forename: S L
authors.initials: SL
authors.lastname: Gray
mesh_terms: D006801:Humans; D008297:Male; D015290:Second Messenger Systems; D015398:Signal Transduction / Q000187:drug effects*; D013094:Spermatozoa / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D013256:Steroids / Q000494:pharmacology*
chemical_list: D013256:Steroids
keywords: Kinase; Phosphoinositide; Second messenger; Spermatozoa; Steroids