title: Primary Marginal Zone Lymphoma of the Subcutis Associated With Panniculitis and Fat Necrosis.
abstract: OBJECTIVE
  Lymphocytic infiltrates in the subcutaneous adipose tissue, often accompanied by fat necrosis, are typically seen in benign panniculitis. Diagnostic considerations include subcutaneous panniculitis-like T-cell lymphoma and cutaneous γδ T-cell lymphoma, whereas a primary subcutaneous B-cell lymphoma in this setting has not been previously described.
  
  
  METHODS
  We report the case of a 72-year-old woman with multiple deep cutaneous nodules on the trunk and upper extremities.
  
  
  RESULTS
  During 3 years of clinical follow-up, new skin nodules developed, while existing lesions remained stable or regressed. No other organ involvement was detected. Sequential biopsy specimens of the subcutaneous lesions revealed patchy, predominantly septal, lymphocytic infiltrates associated with extensive hyaline fat necrosis. The histologic and immunophenotypic features were consistent with marginal zone lymphoma. Genotyping revealed an identical monoclonal immunoglobulin gene rearrangement across all biopsy specimens.
  
  
  CONCLUSIONS
  This case represents, to our knowledge, the first reported case of primary subcutaneous B-cell lymphoma closely associated with panniculitis.
authors.affiliation: From the Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada, and Departments of Pathology and.
authors.forename: M Herman
authors.initials: MH
authors.lastname: Chui
authors.affiliation: Medical Oncology, Toronto General Hospital, University Health Network, Toronto, Canada.
authors.forename: Vishal
authors.initials: V
authors.lastname: Kukreti
authors.affiliation: From the Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada, and Departments of Pathology and.
authors.forename: Cuihong
authors.initials: C
authors.lastname: Wei
authors.affiliation: From the Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada, and Departments of Pathology and jan.delabie@uhn.ca.
authors.forename: Jan
authors.initials: J
authors.lastname: Delabie
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000473:pathology*; D009336:Necrosis / Q000473:pathology; D015434:Panniculitis / Q000209:etiology* / Q000473:pathology
keywords: B-cell lymphoproliferative disorder; Lymphoma; Panniculitis