title: Synthesis of Resveratrol Glycosides by Plant Glucosyltransferase and Cyclodextrin Glucanotransferase and Their Neuroprotective Activity.
abstract: Resveratrol was converted by glucosyltransferase from Phytolacca americana into its 3- and 4'-O-β-D-glucosides. On the other hand, further glycosylation of resveratrol 4'-O-β-D-glucoside by cyclodextrin glucanotransferase gave the 4'-O-β-maltoside, 4'-O-β-maltotrioside, 4'-O-β-maltotetraoside, and 4'-O-β- maltopentaoside of resveratrol. The six resveratrol glycosides synthesized here showed higher phosphodiesterase inhibitory activity than resveratrol.
authors.forename: Kei
authors.initials: K
authors.lastname: Shimoda
authors.forename: Naoji
authors.initials: N
authors.lastname: Kubota
authors.forename: Hatsuyuki
authors.initials: H
authors.lastname: Hamada
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hamada
mesh_terms: D055162:Biocatalysis; D005964:Glucosyltransferases / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology; D029604:Phytolacca americana / Q000201:enzymology*; D010940:Plant Proteins / Q000737:chemistry*; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D018696:Neuroprotective Agents; D010940:Plant Proteins; D013267:Stilbenes; D005964:Glucosyltransferases; C019963:cyclomaltodextrin glucanotransferase; D000077185:Resveratrol