title: Perspective: Dendrimer drugs for infection and inflammation.
abstract: Biologists are dissecting complex biological pathways at breath taking speed. It is opening up new opportunities for the therapeutic evaluation of novel dendrimer drugs. This review focuses on studies of small dendrimers decorated with sulfate, phosphonate, N-acetyl-cysteine, glucosamine and mannose in animal model studies of infection and inflammation. It highlights those animal model studies which have demonstrated the most promising dendrimer drug constructs as potential new medicines. The issues relating to their analytical chemistry that are slowing the progress of dendrimer drugs into the clinic are highlighted. It should be possible to solve these with additional analytical expertise because it is small dendrimers with only 16-32 peripheral groups that make for the best infection and inflammation related medicines. Public-private partnerships are now needed to progress these dendrimer drugs into proof-of-concept clinical trials.
authors.affiliation: Imperial College London & Hammersmith Hospital, Ducane Road, London W12 0NN, UK. Electronic address: s.shaunak@imperial.ac.uk.
authors.forename: Sunil
authors.initials: S
authors.lastname: Shaunak
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry; D050091:Dendrimers / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D007239:Infections / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure
chemical_list: D000893:Anti-Inflammatory Agents; D050091:Dendrimers
keywords: Dendrimer drugs; Infection; Inflammation