title: PLANT MICROBIOME. Salicylic acid modulates colonization of the root microbiome by specific bacterial taxa.
abstract: Immune systems distinguish "self" from "nonself" to maintain homeostasis and must differentially gate access to allow colonization by potentially beneficial, nonpathogenic microbes. Plant roots grow within extremely diverse soil microbial communities but assemble a taxonomically limited root-associated microbiome. We grew isogenic Arabidopsis thaliana mutants with altered immune systems in a wild soil and also in recolonization experiments with a synthetic bacterial community. We established that biosynthesis of, and signaling dependent on, the foliar defense phytohormone salicylic acid is required to assemble a normal root microbiome. Salicylic acid modulates colonization of the root by specific bacterial families. Thus, plant immune signaling drives selection from the available microbial communities to sculpt the root microbiome.
authors.affiliation: Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845, USA. Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. slebeis@utk.edu dangl@email.unc.edu.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Lebeis
authors.affiliation: Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Howard Hughes Medical Institute, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
authors.forename: Sur Herrera
authors.initials: SH
authors.lastname: Paredes
authors.affiliation: Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
authors.forename: Derek S
authors.initials: DS
authors.lastname: Lundberg
authors.affiliation: Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Breakfield
authors.affiliation: Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
authors.forename: Jase
authors.initials: J
authors.lastname: Gehring
authors.affiliation: Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
authors.forename: Meredith
authors.initials: M
authors.lastname: McDonald
authors.affiliation: Joint Genome Institute, U.S. Department of Energy, Walnut Creek, CA, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Malfatti
authors.affiliation: Joint Genome Institute, U.S. Department of Energy, Walnut Creek, CA, USA.
authors.forename: Tijana
authors.initials: T
authors.lastname: Glavina del Rio
authors.affiliation: Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
authors.forename: Corbin D
authors.initials: CD
authors.lastname: Jones
authors.affiliation: Joint Genome Institute, U.S. Department of Energy, Walnut Creek, CA, USA.
authors.forename: Susannah G
authors.initials: SG
authors.lastname: Tringe
authors.affiliation: Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Howard Hughes Medical Institute, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. slebeis@utk.edu dangl@email.unc.edu.
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Dangl
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D018407:Bacterial Physiological Phenomena; D064307:Microbiota / Q000187:drug effects / Q000502:physiology*; D010937:Plant Growth Regulators / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D018517:Plant Roots / Q000235:genetics / Q000276:immunology* / Q000382:microbiology*; D020156:Salicylic Acid / Q000378:metabolism* / Q000494:pharmacology; D012988:Soil Microbiology
chemical_list: D010937:Plant Growth Regulators; D020156:Salicylic Acid