title: High Killips Class as a Predictor of New-onset Atrial Fibrillation Following Acute Myocardial Infarction: Systematic Review and Meta-analysis.
abstract: BACKGROUND
  Recent observational studies have shown that patients with higher Killips score (>I) have higher risk of new-onset atrial fibrillation (NOAF) following acute myocardial infarction (AMI), while others drew a neutral conclusion. The ultimate predictive value of high Killips class on NOAF remained obscure.
  
  
  METHODS
  PubMed, Web of Science, China National Knowledge Infrastructure, and the Cochrane Controlled Trials Register Databases were searched until February 2015. Of the 3732 initially identified studies, 5 observational studies with 10,053 patients were analyzed.
  
  
  RESULTS
  The meta-analysis of these studies showed that higher Killips score on admission was associated with higher incidence of NOAF following AMI (odds ratio = 2.29, 95% confidence interval 1.96-2.67, P < 0.00001), while no significant differences exist among individual trials (P = 0.14 and I2 = 43%).
  
  
  CONCLUSIONS
  Killips class >I was associated with the higher opportunity of developing NOAF following AMI.
authors.forename: En-Yuan
authors.initials: EY
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Cui
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Tong
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Tianjin Key Laboratory of Ionic-molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China.
authors.forename: Guang-Ping
authors.initials: GP
authors.lastname: Li
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications*; D012307:Risk Factors