title: Bougainvillea spectabilis Exhibits Antihyperglycemic and Antioxidant Activities in Experimental Diabetes.
abstract: The study investigates the effects of aqueous extract of Bougainvillea spectabilis leaves on blood glucose, glycosylated hemoglobin, lipid profile, oxidative stress, and on DNA damage, if any, as well as on liver and kidney functions in streptozotocin-induced diabetes in Wistar rats. Daily administration of the aqueous extract of B spectabilis leaves for 28 days resulted in significant reduction in hyperglycemia and hyperlipidemia as evident from restoration of relevant biochemical markers following extract administration. The extract also exhibited significant antioxidant activity as evidenced from the enzymatic and nonenzymatic responses and DNA damage markers. The extract restored kidney and liver functions to normal and proved to be nontoxic. A marked improvement in the histological changes of tissues was also observed. The present study documented antihyperglycemic, antihyperlipidemic, and antioxidative potentials of the aqueous extract of B spectabilis leaves without any toxicity in streptozotocin-treated Wistar rats.
authors.affiliation: Jiwaji University, Gwalior, India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Chauhan
authors.affiliation: Jiwaji University, Gwalior, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Mahajan
authors.affiliation: Jiwaji University, Gwalior, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Kulshrestha
authors.affiliation: Jiwaji University, Gwalior, India.
authors.forename: Sadhana
authors.initials: S
authors.lastname: Shrivastava
authors.affiliation: Allahabad University, Allahabad, India.
authors.forename: Bechan
authors.initials: B
authors.lastname: Sharma
authors.affiliation: Jiwaji University, Gwalior, India.
authors.forename: H M
authors.initials: HM
authors.lastname: Goswamy
authors.affiliation: Jiwaji University, Gwalior, India gbksprasad@gmail.com.
authors.forename: G B K S
authors.initials: GB
authors.lastname: Prasad
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D039281:Nyctaginaceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts
keywords: blood glucose; diabetes mellitus; hyperglycemia; hyperlipidemia; oxidative stress