title: Metabolomics techniques for nanotoxicity investigations.
abstract: Nanomaterials are commonly defined as engineered structures with at least one dimension of 100 nm or less. Investigations of their potential toxicological impact on biological systems and the environment have yet to catch up with the rapid development of nanotechnology and extensive production of nanoparticles. High-throughput methods are necessary to assess the potential toxicity of nanoparticles. The omics techniques are well suited to evaluate toxicity in both in vitro and in vivo systems. Besides genomic, transcriptomic and proteomic profiling, metabolomics holds great promises for globally evaluating and understanding the molecular mechanism of nanoparticle-organism interaction. This manuscript presents a general overview of metabolomics techniques, summarizes its early application in nanotoxicology and finally discusses opportunities and challenges faced in nanotoxicology.
authors.affiliation: MOE Key Laboratory of Drug Quality Control & Pharmacovigilance, China Pharmaceutical University, Nanjing, 210009, China.|State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Mengying
authors.initials: M
authors.lastname: Lv
authors.affiliation: MOE Key Laboratory of Drug Quality Control & Pharmacovigilance, China Pharmaceutical University, Nanjing, 210009, China.|State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Wanqiu
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Hulin
authors.initials: H
authors.lastname: Jiang
authors.affiliation: MOE Key Laboratory of Drug Quality Control & Pharmacovigilance, China Pharmaceutical University, Nanjing, 210009, China.|State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Chen
authors.affiliation: MOE Key Laboratory of Drug Quality Control & Pharmacovigilance, China Pharmaceutical University, Nanjing, 210009, China.|State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: MOE Key Laboratory of Drug Quality Control & Pharmacovigilance, China Pharmaceutical University, Nanjing, 210009, China.|State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Zunjian
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory of Drug Quality Control & Pharmacovigilance, China Pharmaceutical University, Nanjing, 210009, China.|State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Fengguo
authors.initials: F
authors.lastname: Xu
mesh_terms: D006801:Humans; D053858:Metabolic Networks and Pathways; D055432:Metabolomics; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D036103:Nanotechnology; D018675:Toxicity Tests