title: Fat Intake Is Not Linked to Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis.
abstract: BACKGROUND
  Since the late 1960s, the average global supply of fat has increased by 20 g per capita per day. While fat intake has been considered a potential risk factor for prostate cancer (Pca), the hypothesis from previous epidemiologic studies remained equivocal.
  
  
  METHODS
  Relevant cohort studies were identified through a literature search in PubMed, ScienceDirect and Wiley Online Library up to March 1, 2015. A systematic review and dose-response meta-analysis were used to assess the relationship between fat intake and the risk for Pca.
  
  
  RESULTS
  We identified 14 cohort studies, which included 37,349 cases and a total of 751,030 participants. We found no evidence of a non-linear association between fat intake and the risk for Pca. Overall, the summarized relative risks for every 28.35 g increment a day was 0.99 (95%CI: 0.98, 1.01; P=0.94; n=13) for total fat intake, 1.00 (95%CI: 1.00, 1.00; P=0.72; n=9) for saturated fat, 0.99 (95%CI: 0.95, 1.03; P=0.55; n=7) for polyunsaturated fat, and 1.00 (95%CI: 0.95, 1.04; P=0.85; n=8) for monounsaturated fat. Additionally, there was no link to the risk for advanced stage Pca regarding total fat intake (RR=1.02, 95%CI: 0.96, 1.08; P=0.63; n=5), saturated fat (RR=0.96, 95%CI: 0.84, 1.11; P=0.61; n=6), polyunsaturated fat (RR=0.96, 95%CI: 0.79, 1.17; P=0.68; n=6), or monounsaturated fat (RR=0.96, 95%CI: 0.86, 1.07; P=0.42; n=6). Subgroup and sensitively analyses showed consistent results.
  
  
  CONCLUSIONS
  Little evidence from published cohort studies supports the statement that total fat, saturated fat or unsaturated fat intake increases the risk for Pca or advanced stage Pca.
authors.affiliation: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China; Center for Evidence-Based Medicine and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Han
authors.affiliation: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China; Center for Evidence-Based Medicine and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zeng
authors.affiliation: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China; Center for Evidence-Based Medicine and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
authors.forename: Tong-Zu
authors.initials: TZ
authors.lastname: Liu
authors.affiliation: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China; Center for Evidence-Based Medicine and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
authors.forename: Zheng-Yan
authors.initials: ZY
authors.lastname: Gao
mesh_terms: D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000209:etiology*; D012306:Risk
chemical_list: D004041:Dietary Fats