title: Relationship between insulin resistance and circulating endothelial cells in pre-eclampsia.
abstract: Endothelial dysfunction and insulin resistance (IR) are established features of pre-eclampsia, however the cause and effect relationship between them remain unexplained. Circulating endothelial cells (CEC) are increased in pre-eclampsia and appear to correlate with the degree of endothelial dysfunction. We hypothesised that CEC count in pre-eclampsia would correlate with IR and might provide a simple measure of IR in pregnancies complicated by the disease. CEC count and IR were measured in 10 women with pre-eclampsia and 10 normal pregnant controls matched for maternal age, body mass index and gestational age during the third trimester. CEC count was determined using an established immunomagnetic bead separation method and IR was measured by the homeostasis model test. CEC count and IR were significantly increased in pre-eclampsia compared to normal pregnancy. However, there was no correlation between the CEC count and IR in pre-eclampsia. The data suggest that CEC count in pre-eclampsia is not a useful measure on its own of IR in pregnancies complicated by the disease.
authors.affiliation: a School of Life Sciences, Kingston University London , Kingston upon Thames , UK .|b Department of Obstetrics & Gynaecology , Kingston Hospital , Kingston upon Thames , UK , and.
authors.forename: Nick
authors.initials: N
authors.lastname: Anim-Nyame
authors.affiliation: a School of Life Sciences, Kingston University London , Kingston upon Thames , UK .|b Department of Obstetrics & Gynaecology , Kingston Hospital , Kingston upon Thames , UK , and.
authors.forename: Anshuman
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: c School of Pharmacy, Kingston University London , Kingston upon Thames , UK.
authors.forename: Nick
authors.initials: N
authors.lastname: Freestone
authors.affiliation: c School of Pharmacy, Kingston University London , Kingston upon Thames , UK.
authors.forename: Francesca I F
authors.initials: FI
authors.lastname: Arrigoni
mesh_terms: D000328:Adult; D015992:Body Mass Index; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008423:Maternal Age; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
keywords: Circulating endothelial cells; endothelial dysfunction; insulin resistance; pre-eclampsia