title: The effects of screening and intervention of subclinical hypothyroidism on pregnancy outcomes: a prospective multicenter single-blind, randomized, controlled study of thyroid function screening test during pregnancy.
abstract: OBJECTIVE
  To evaluate the effect of subclinical hypothyroidism (SCH) screening and intervention on pregnancy outcomes and explore the significance of thyroid function during early pregnancy.
  
  
  METHODS
  Pregnant women were recruited from Peking Union Medical College Hospital (screening group for measuring thyroid function and thyroid antibody in early pregnancy) and Haidian Maternal & Child Health Hospital (control group whose serum was stored and measured shortly after delivery) from July 2011 to December 2012. Thyrotropin levels 2.5-10 mIU/L and free T4 levels in normal range were considered SCH. Some of the screening group were treated with levothyroxine and adjusted. The others did not take medicine but kept a regular follow-up visit to doctors after antenatal clinic. The pregnancy outcomes and complications were compared.
  
  
  RESULTS
  1671 women (675 in screening group and 996 in control group) were recruited. 419 (167 from screening group) women was diagnosed as SCH. In screening group, 105 SCH and 4 hypothyroid women received thyroid hormone replacement therapy. The miscarriage and fetal macrosomia risks were lower, and cesarean was higher in screening group than control.
  
  
  CONCLUSIONS
  Screening and intervention of SCH can significantly reduce the incidence rate of miscarriage.
authors.affiliation: a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital , Beijing , China .
authors.forename: Liangkun
authors.initials: L
authors.lastname: Ma
authors.affiliation: b Prenatal Screening Center, Department of Obstetrics and Gynecology, Haidian Maternal & Child Health Hospital , Beijing , China .
authors.forename: Hong
authors.initials: H
authors.lastname: Qi
authors.affiliation: c Department of Endocrinology , Endocrinal Key Laboratory of Ministry of Health, Peking Union Medical College Hospital , Beijing , China .
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chai
authors.affiliation: a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital , Beijing , China .
authors.forename: Fang
authors.initials: F
authors.lastname: Jiang
authors.affiliation: a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital , Beijing , China .
authors.forename: Su
authors.initials: S
authors.lastname: Mao
authors.affiliation: a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital , Beijing , China .
authors.forename: Juntao
authors.initials: J
authors.lastname: Liu
authors.affiliation: b Prenatal Screening Center, Department of Obstetrics and Gynecology, Haidian Maternal & Child Health Hospital , Beijing , China .
authors.forename: Shaoqin
authors.initials: S
authors.lastname: Zhang
authors.affiliation: c Department of Endocrinology , Endocrinal Key Laboratory of Ministry of Health, Peking Union Medical College Hospital , Beijing , China .
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Lian
authors.affiliation: d Department of Pediatrics , Peking Union Medical College Hospital , Beijing , China , and.
authors.forename: Xiujing
authors.initials: X
authors.lastname: Sun
authors.affiliation: d Department of Pediatrics , Peking Union Medical College Hospital , Beijing , China , and.
authors.forename: Danhua
authors.initials: D
authors.lastname: Wang
authors.affiliation: e Early Child Health and Development Centre, Haidian Maternal & Child Health Hospital , Beijing , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.affiliation: e Early Child Health and Development Centre, Haidian Maternal & Child Health Hospital , Beijing , China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis*; D008403:Mass Screening / Q000706:statistics & numerical data*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis*; D011256:Pregnancy Outcome; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin
keywords: Pregnancy outcome; subclinical hypothyroidism; thyroid function tests