title: Biomarkers for immune thrombocytopenia.
abstract: Immune thrombocytopenia is an autoimmune disease with abnormal biomarkers. Immune thrombocytopenia pathogenesis is a complicated process in which the patient's immune system is activated by platelet autoantigens resulting in immune mediated platelet destruction or suppression of platelet production. The autoantibodies produced by autoreactive B cells against self antigens are considered to play a crucial role. In addition, biomarkers such as transforming growth factor-beta1,Toll-like receptors,T helper 1 andT helper 2 cytokine bias, Notch signaling and abnormal biomarker in megakaryocyte maturation are involved in the pathogenesis of this disease. With the genomewide association study on immune thrombocytopenia, more biomarkers will be founded in the future. They may provides a theoretical basis for the mechanism and treatment of immune thrombocytopenia.
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Rd, Jinan, Shandong 250012 PR China.
authors.forename: Lingjia
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Hematology, the central Hospital of TaiAn, TaiAn, PR China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Jinan Stomatological Hospital, Jinan, PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Immunology, School of Medicine, Shandong University, Jinan, PR China.
authors.forename: Yongyu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Rd, Jinan, Shandong 250012 PR China.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Ji
keywords: B cell; Biomarker; Immune thrombocytopenia; Pathogenesis; T cell