title: [Angiopoietins predict long-term outcomes after aneurysmal subarachnoid hemorrhage during an early period].
abstract: OBJECTIVE
  To evaluate the association between serum levels of angiopoietins (Ang) during an early period (within 72 h) and clinical outcomes after aneurysmal subarachnoid haemorrhage (aSAH).
  
  
  METHODS
  This prospective study was conducted at Department of Neurosurgery, Tianjin Medical University General Hospital. Blood samples from 37 aSAH patients were collected at 8 h (or < 8 h), 24 h, 72 h after an onset of SAH. The serum levels of Ang-1, Ang-2 and Tie-2 were measured by enzyme-linked immunosorbent assay (ELISA). They were followed up for 3 months by Glasgow outcome score extended (GOSE). Those with GOSE > 5 were counted as a good outcome while those with GOSE ≤ 5 had a poor outcome.
  
  
  RESULTS
  A total of 37 patients with aSAH and 39 healthy controls (HC) were enrolled. The aSAH patients showed a significant rise of Ang-1 within 8 h as compared with HC. The outcomes were good (n = 15) and poor (n = 22). Serum Ang-1 at 8 h (or < 8 h), 24 h and 72 h in good outcomers showed significantly higher than that in poor outcomers [(52 ± 24) vs (37 ± 17) mg/L, (62 ± 26) vs (45 ± 17) mg/L, (107 ± 27) vs (72 ± 18) mg/L]. The serum level of Ang-1 at 8 h and 24 h was one of independent risk factors for aSAH patients by multiariable Logistic regression analysis [adjected OR (95% CI) 1.095 (1.015-1.181) and 1.109 (1.016-1.211)] (P < 0.05). High serum level of Ang-1 during an early period (within 72 h) was associated with good outcomers (r = 0.627, P < 0.001).
  
  
  CONCLUSIONS
  The serum levels of angiopoietins are significantly altered in aSAH patients, especially higher in good outcomers. And abnormal levels of angiopoietins may affect early brain injury (EBI) after SAH, structural integrity and recovery of blood-brain barrier (BBB) and long-term outcomes in aSAH patients.
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital & Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair & Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations & Regeneration of Nervous System, Tianjin 300052, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital & Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair & Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations & Regeneration of Nervous System, Tianjin 300052, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital & Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair & Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations & Regeneration of Nervous System, Tianjin 300052, China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital & Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair & Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations & Regeneration of Nervous System, Tianjin 300052, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital & Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair & Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations & Regeneration of Nervous System, Tianjin 300052, China.
authors.forename: Rongcai
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital & Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair & Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations & Regeneration of Nervous System, Tianjin 300052, China.
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Yue
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital & Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair & Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations & Regeneration of Nervous System, Tianjin 300052, China; Email: jianningzhang@hotmail.com.
authors.forename: Jianning
authors.initials: J
authors.lastname: Zhang
mesh_terms: D042682:Angiopoietins; D001930:Brain Injuries; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D002532:Intracranial Aneurysm; D019635:Neurosurgical Procedures; D011446:Prospective Studies; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage; D016896:Treatment Outcome
chemical_list: D042682:Angiopoietins