title: Recent Advances in the Synthesis of Carotenoid-Derived Flavours and Fragrances.
abstract: Carotenoids are important isoprenoid compounds whose oxidative degradation produces a plethora of smaller derivatives, called apocarotenoids, which possess a range of different chemical structures and biological activities. Among these natural products, compounds having less than 15 carbon atoms in their frameworks are often relevant flavours or fragrances and their manufacturing represents an important economic resource for chemical companies. The strict correlation between stereochemical structure and odour has made the stereospecific synthesis of the latter biological active compounds increasingly important. In this review, the recent advances on the synthesis of the most relevant carotenoid-derived flavours and fragrances are discussed. In particular, the new synthetic methods that have given new and innovative perspectives from a scientific standpoint and the preparative approaches that might possess industrial importance are described thoroughly.
authors.affiliation: Istituto di Chimica del Riconoscimento Molecolare, Via Mancinelli 7, I-20131 Milano, Italy. stefano.serra@cnr.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Serra
mesh_terms: D002338:Carotenoids / Q000737:chemistry*; D005421:Flavoring Agents / Q000138:chemical synthesis*; D006801:Humans; D045792:Norisoprenoids / Q000138:chemical synthesis; D009812:Odorants / Q000032:analysis; D010084:Oxidation-Reduction; D010476:Perfume / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D005421:Flavoring Agents; D045792:Norisoprenoids; D010476:Perfume; D002338:Carotenoids
keywords: apocarotenoids; carotenoids; enzymes; flavours; fragrances; organic synthesis; resolution; stereoselective synthesis