title: A case of primary pancreatic lymphoblastic lymphoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration.
abstract: Pancreatic involvement is an extremely rare manifestation of lymphoblastic lymphoma (LBL), and only a few cases have been reported. We report a case of LBL arising from the pancreas that was diagnosed using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The patient was a 57-year-old female who had suffered from abdominal pain for 2 weeks. A physical examination revealed an upper abdominal mass, but did not detect peripheral lymphadenopathy. Imaging studies including computed tomography (CT) and (18)F-fluorodeoxy glucose (FDG)-positron emission tomography-CT revealed an enlarged pancreatic body, which was positive for FDG uptake. EUS-FNA detected medium-sized proliferating atypical lymphocytes, and immunohistochemical staining demonstrated that these cells were positive for CD20, CD10, PAX5, and terminal deoxynucleotidyl transferase. A bone marrow examination was negative for lymphoma infiltration, and a diagnosis of LBL arising from the pancreas was made. The patient was successfully treated with a combination of chemotherapy and pancreatic irradiation.
authors.affiliation: Department of Gastroenterology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, Japan, nakajisou1978@yahoo.co.jp.
authors.forename: So
authors.initials: S
authors.lastname: Nakaji
authors.forename: Nobuto
authors.initials: N
authors.lastname: Hirata
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Shiratori
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujii
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishii
authors.forename: Kosei
authors.initials: K
authors.lastname: Matsue
authors.forename: Kazuei
authors.initials: K
authors.lastname: Hoshi
mesh_terms: D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology* / Q000628:therapy