title: Moxifloxacin Induced Seizures -A Case Report.
abstract: A 73-year-old female patient developed a generalized tonic-clonic seizure on the 6th day after treatment with moxifloxacin 400 mg daily intravenously for appendicitis. This patient had atrial fibrillation and history of a surgery for intracerebral hemorrhage, with impaired renal function and liver function, but without history of seizures. Moxifloxacin was discontinued and switched to cefuroxime. The patient remained seizure-free at discharge four days later. The naranjo adverse drug reaction probability scale score was 4, indicating a possible adverse reaction to moxifloxacin. The potential risk factors related to moxifloxacin-induced seizures are discussed. It highlights that preexisting central nervous system disease, elderly female with lower bodyweight and severe renal impairment may be the risk factors involved in moxifloxacin-induced seizures.
authors.affiliation: 1. Dept. of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009 , China ; 2. Dept. of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou 310012 , China.
authors.forename: Jiana
authors.initials: J
authors.lastname: Shi
authors.affiliation: 1. Dept. of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009 , China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Xu
keywords: Antibiotics; Fluoroquinolones; Moxifloxacin; Seizures; Side effects