title: A new 5-alkylresorcinol glucoside derivative from Cybianthus magnus.
abstract: One new 5-alkylresorcinol glucoside (1) was isolated from leaves of Cybianthus magnus, along with 12 known compounds (2-13), isolated from four plants belonging to Myrsinaceae family. Their structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. Among the tested molecules, only compound 2 displayed a strong cytotoxic activity with IC50 values ranging between 22 and 100 μM for all cell lines tested. One new 5-alkylresorcinol glucoside (1) was isolated from leaves of Cybianthus magnus, along with 12 known compounds, isolated from four plants belonging to Myrsinaceae family (2, 3 isolated from C. magnus; 4-7, 10 and 11 isolated from Myrsine latifolia; 4, 8 and 9 isolated from Myrsine sessiflora; 6, 7, 10, 12 and 13 isolated from Myrsine congesta). Their structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. So far, only nine 5-alkylresorcinol glucosides were isolated from leaves of Grevillea robusta. Since resorcinols are known to exhibit strong cytotoxic activity, compounds 1 and 2 were tested against cell lines 3T3, H460, DU145 and MCF-7 for cytotoxicity in vitro and compounds 3-13 were tested for their antileishmanial activity. Compound 2 displayed a strong cytotoxic activity with IC50 values ranging between 22 and 100 μM for all tested cell lines. Compounds 3-13 were not active against Leishmania amazonensis amastigotes.
authors.affiliation: a Instituto de Investigaciones de la Amazonía Peruana (IIAP) , Iquitos , Peru.
authors.forename: B
authors.initials: B
authors.lastname: Cabanillas
authors.affiliation: b Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia , Lima , Peru.
authors.forename: P
authors.initials: P
authors.lastname: Vásquez-Ocmín
authors.affiliation: c Institut de Chimie Moléculaire de Reims UMR CNRS, Université , de Reims BP 1039, 51687 , REIMS , Cedex , France.
authors.forename: I
authors.initials: I
authors.lastname: Zebiri
authors.affiliation: a Instituto de Investigaciones de la Amazonía Peruana (IIAP) , Iquitos , Peru.
authors.forename: E
authors.initials: E
authors.lastname: Rengifo
authors.affiliation: d Laboratoire de Pharmacochimie et Pharmacologie pour le Développement, Pharma-DEV, Université de Toulouse, UPS, UMR 152 , F-31062 Toulouse , Cedex 9 , France.|e Institut de Recherche pour le Développement (IRD) , UMR152, Mission IRD, Casilla 18-1209, Lima , Peru.
authors.forename: M
authors.initials: M
authors.lastname: Sauvain
authors.affiliation: d Laboratoire de Pharmacochimie et Pharmacologie pour le Développement, Pharma-DEV, Université de Toulouse, UPS, UMR 152 , F-31062 Toulouse , Cedex 9 , France.
authors.forename: H L
authors.initials: HL
authors.lastname: Le
authors.affiliation: b Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia , Lima , Peru.
authors.forename: A
authors.initials: A
authors.lastname: Vaisberg
authors.affiliation: c Institut de Chimie Moléculaire de Reims UMR CNRS, Université , de Reims BP 1039, 51687 , REIMS , Cedex , France.
authors.forename: L
authors.initials: L
authors.lastname: Voutquenne-Nazabadioko
authors.affiliation: d Laboratoire de Pharmacochimie et Pharmacologie pour le Développement, Pharma-DEV, Université de Toulouse, UPS, UMR 152 , F-31062 Toulouse , Cedex 9 , France.|f IRD, UMR152 Pharma-Dev , F-31062 Toulouse , Cedex 9 , France.
authors.forename: M
authors.initials: M
authors.lastname: Haddad
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D029623:Primulaceae / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D012118:Resorcinols
keywords: Myrsinaceae; alkylresorcinol; anti-leishmaniasis, cytotoxicity; secondary metabolites