title: Boronic Acid-Based Carbohydrate Sensing.
abstract: The covalent boron-diol interaction enables elaborate design of boronic acid-based saccharide sensors. Over the last decade, this research topic has been well developed thanks to the integration of boronic acid chemistry with a range of techniques, including supramolecular chemistry, materials chemistry, surface modification, and nanotechnology. New sensing strategies and platforms have been introduced and remarkable progress has been achieved to fully utilize the unique property of boron-diol interaction and to improve the binding affinity towards different targets, especially under physiological conditions. In this review, the latest progress over the past 30 months (from late 2012 to early 2015) is highlighted and discussed to shed light on this versatile and promising platform for saccharide sensing.
authors.affiliation: School of Chemistry, University of Birmingham, Birmingham, West Midlands, B15 2TT, UK.
authors.forename: Wenlei
authors.initials: W
authors.lastname: Zhai
authors.affiliation: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
authors.forename: Tony D
authors.initials: TD
authors.lastname: James
authors.affiliation: School of Chemistry, University of Birmingham, Birmingham, West Midlands, B15 2TT, UK. j.s.fossey@bham.ac.uk.
authors.forename: John S
authors.identifier: http://orcid.org/0000-0002-2626-5117
authors.initials: JS
authors.lastname: Fossey
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods; D001897:Boronic Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D008958:Models, Molecular; D054802:Molecular Imprinting / Q000379:methods*; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D002241:Carbohydrates; D020100:Hydrogels; D010455:Peptides; D011108:Polymers
keywords: boronic acid; functionalized polymers; molecular sensors; saccaride sensing; sensors