title: Assessing the Reliability of a Semiautomated Segmentation Algorithm for Quantifying Erosions in the Metacarpophalangeal Joints of Patients with Rheumatoid Arthritis.
abstract: OBJECTIVE
  Assess the reliability of early erosions in rheumatoid arthritis (EERA) software for quantifying erosive damage to the metacarpophalangeal joints of patients with rheumatoid arthritis (RA).
  
  
  METHODS
  One hundred magnetic resonance image sets from 68 patients with early referral RA were evaluated. Reliability was assessed using 95% limits of agreement and intraclass correlation coefficient (ICC) with 95% CI.
  
  
  RESULTS
  Limits of agreement linearly depended on erosion volume: 0.44× between readers and 0.19× within readers. Interrater ICC was 0.976 (95% CI 0.965-0.984) and intrarater ICC was 0.996 (95% CI 0.994-0.997).
  
  
  CONCLUSIONS
  EERA is highly reproducible for quantifying erosions in patients with early RA.
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Tomizza
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Jessome
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Joshua
authors.initials: J
authors.lastname: Barbosa
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Beattie
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: William G
authors.initials: WG
authors.lastname: Bensen
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Raja S
authors.initials: RS
authors.lastname: Bobba
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Alfred A
authors.initials: AA
authors.lastname: Cividino
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Emond
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Chris
authors.initials: C
authors.lastname: Gordon
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Hart
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: George
authors.initials: G
authors.lastname: Ioannidis
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Melissa X P
authors.initials: MX
authors.lastname: Koh
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Maggie
authors.initials: M
authors.lastname: Larché
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Ruben
authors.initials: R
authors.lastname: Tavares
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
authors.forename: Stephen
authors.initials: S
authors.lastname: Tytus
authors.affiliation: From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton. jd.adachi@sympatico.ca.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Adachi
mesh_terms: D000368:Aged; D000465:Algorithms; D001172:Arthritis, Rheumatoid / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008662:Metacarpophalangeal Joint / Q000473:pathology*; D008875:Middle Aged; D015203:Reproducibility of Results; D012720:Severity of Illness Index
keywords: JOINT EROSIONS; MAGNETIC RESONANCE IMAGING; METACARPOPHALANGEAL JOINT; REPRODUCIBILITY OF RESULTS; RHEUMATOID ARTHRITIS