title: Antiproliferative Activity of seco-Oxacassanes from Acacia schaffneri.
abstract: This work reports the antiproliferative activity of seco-oxacassanes 1-3, isolated from Acacia schaffneri, against human colon (HT-29), lung (A-549), and melanoma (UACC-62) cancer cell lines, as well as against their non-malignant counterparts CCD-841 CoN, MRC-5, and VH-10, respectively, using the sulforhodamine B test. While compounds 1 and 3 were inactive, 2 presented strong activity with IC50 values between 0.12 and 0.92 μg mL(-1). The cytotoxicity mechanisms of 2 were investigated by cell cycle analysis and through DNA repair pathways, indicating that the compound is capable of arresting the cell cycle in the G0/G1 phase. This effect might be generated through damage to DNA by alkylation. In addition, compound 2 was able to decrease HT-29 migration.
authors.forename: J Martín
authors.initials: JM
authors.lastname: Torres-Valencia
authors.forename: Virginia
authors.initials: V
authors.lastname: Motilva
authors.forename: J Jesús
authors.initials: JJ
authors.lastname: Manríquez-Torres
authors.forename: Sofía
authors.initials: S
authors.lastname: García-Mauriño
authors.forename: Miguel
authors.initials: M
authors.lastname: López-Lázaro
authors.forename: Hanaa
authors.initials: H
authors.lastname: Zbakh
authors.forename: José M
authors.initials: JM
authors.lastname: Calderón-Montaño
authors.forename: Mario A
authors.initials: MA
authors.lastname: Gómez-Hurtado
authors.forename: Juan A
authors.initials: JA
authors.lastname: Gayosso-De-Lucio
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Cerda-García-Rojas
authors.forename: Pedro
authors.initials: P
authors.lastname: Joseph-Nathan
mesh_terms: D000045:Acacia / Q000737:chemistry*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D008545:Melanoma / Q000188:drug therapy / Q000503:physiopathology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004224:Diterpenes; D006131:Growth Inhibitors; D010936:Plant Extracts