title: Resting-state oscillatory dynamics in sensorimotor cortex in benign epilepsy with centro-temporal spikes and typical brain development.
abstract: Benign Epilepsy with Centro-Temporal Spikes (BECTS) is a common childhood epilepsy associated with deficits in several neurocognitive domains. Neurophysiological studies in BECTS often focus on centro-temporal spikes, but these correlate poorly with morphology and cognitive impairments. To better understand the neural profile of BECTS, we studied background brain oscillations, thought to be integrally involved in neural network communication, in sensorimotor areas. We used independent component analysis of temporally correlated sources on magnetoencephalography recordings to assess sensorimotor resting-state network activity in BECTS patients and typically developing controls. We also investigated the variability of oscillatory characteristics within focal primary motor cortex (M1), localized with a separate finger abduction task. We hypothesized that background oscillations would differ between patients and controls in the sensorimotor network but not elsewhere, especially in the beta band (13-30 Hz) because of its role in network communication and motor processing. The results support our hypothesis: in the sensorimotor network, patients had a greater variability in oscillatory amplitude compared to controls, whereas there was no difference in the visual network. Network measures did not correlate with age. The coefficient of variation of resting M1 peak frequency correlated negatively with age in the beta band only, and was greater than average for a number of patients. Our results point toward a "disorganized" functional sensorimotor network in BECTS, supporting a neurodevelopmental delay in sensorimotor cortex. Our findings further suggest that investigating the variability of oscillatory peak frequency may be a useful tool to investigate deficits of disorganization in neurodevelopmental disorders.
authors.affiliation: CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom.
authors.forename: Loes
authors.initials: L
authors.lastname: Koelewijn
authors.affiliation: CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom.
authors.forename: Khalid
authors.initials: K
authors.lastname: Hamandi
authors.affiliation: CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Brindley
authors.affiliation: Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Brookes
authors.affiliation: CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom.
authors.forename: Bethany C
authors.initials: BC
authors.lastname: Routley
authors.affiliation: Schools of Pharmacy and Psychology, University of Auckland, Auckland, New Zealand.
authors.forename: Suresh D
authors.initials: SD
authors.lastname: Muthukumaraswamy
authors.affiliation: Dyscovery Centre, University of South Wales, Newport, United Kingdom.
authors.forename: Natalie
authors.initials: N
authors.lastname: Williams
authors.affiliation: Dyscovery Centre, University of South Wales, Newport, United Kingdom.
authors.forename: Marie A
authors.initials: MA
authors.lastname: Thomas
authors.affiliation: Dyscovery Centre, University of South Wales, Newport, United Kingdom.
authors.forename: Amanda
authors.initials: A
authors.lastname: Kirby
authors.affiliation: Child Health, University Hospital of Wales, Cardiff, United Kingdom.
authors.forename: Johann
authors.initials: J
authors.lastname: Te Water Naudé
authors.affiliation: Child Health, University Hospital of Wales, Cardiff, United Kingdom.
authors.forename: Frances
authors.initials: F
authors.lastname: Gibbon
authors.affiliation: CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom.
authors.forename: Krish D
authors.initials: KD
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology; D001611:Beta Rhythm; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000503:physiopathology*; D005260:Female; D005385:Fingers / Q000294:innervation; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007361:Intelligence Tests; D015225:Magnetoencephalography; D008297:Male; D009044:Motor Cortex / Q000254:growth & development / Q000503:physiopathology; D009415:Nerve Net / Q000503:physiopathology; D009483:Neuropsychological Tests; D066191:Sensorimotor Cortex / Q000254:growth & development* / Q000503:physiopathology*; D014795:Visual Pathways / Q000503:physiopathology
keywords: benign epilepsy with centro-temporal spikes; beta-band oscillations; magnetoencephalography; resting-state networks; sensorimotor cortex