title: Kocher-Debré-Semelaigne syndrome with rhabdomyolysis and increased creatinine.
abstract: Association of Kocher-Debré-Semelaigne syndrome-a myopathy of hypothyroidism in childhood characterized by muscular hypertrophy, with rhabdomyolysis is very rare. We present a case of Kocher-Debré-Semelaigne syndrome with rhabdomyolysis secondary to Hashimoto's thyroiditis. He had muscular symptoms simulating poly/dermatomyositis, massively elevated creatine kinase (CK) levels and high creatinine levels. All of the findings reversed on treatment of hypothyroidism. The response to the therapy strongly suggested that Kocher-Debré-Semelaigne (KDS) syndrome was the underlying etiology. Serum thyroid- stimulating hormone levels should be routinely determined in all patients with muscular symptoms and/or elevation of CK and creatinine, keeping KDS syndrome in mind.
authors.forename: Emine Ayça
authors.initials: EA
authors.lastname: Cimbek
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Şen
authors.forename: Sevil Arı
authors.initials: SA
authors.lastname: Yuca
authors.forename: Demet
authors.initials: D
authors.lastname: Çam
authors.forename: Celal
authors.initials: C
authors.lastname: Gür
authors.forename: Harun
authors.initials: H
authors.lastname: Peru
mesh_terms: D000293:Adolescent; D003409:Congenital Hypothyroidism / Q000097:blood / Q000150:complications*; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood*; D050031:Hashimoto Disease / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006984:Hypertrophy / Q000097:blood / Q000150:complications*; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009135:Muscular Diseases / Q000097:blood / Q000150:complications*; D012206:Rhabdomyolysis / Q000097:blood / Q000209:etiology*; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D003404:Creatinine; D003402:Creatine Kinase; D013974:Thyroxine