title: Association between Triclosan-Coated Sutures for Abdominal Wall Closure and Incisional Surgical Site Infection after Open Surgery in Patients Presenting with Fecal Peritonitis: A Randomized Clinical Trial.
abstract: BACKGROUND
  A factor that may influence the incidence of surgical site infections (SSIs) is the suture used for closure of the abdominal wall because bacteria may adhere to the suture material. Sutures can be coated with antibacterial substances that may reduce the bacterial load in the incision.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the effect of triclosan-coated sutures used in abdominal wall closure in patients with fecal peritonitis.
  
  
  METHODS
  A randomized study was performed. Inclusion criteria were intra-operative diagnosis of fecal peritonitis secondary to acute diverticulitis perforation, neoplastic tumor perforation, or colorectal anastomotic leak of previous elective colorectal resection. The patients were randomly assigned to either abdominal wall closure with triclosan-coated sutures (group 1) or sutures without triclosan (group 2).
  
  
  RESULTS
  Fifty patients were included in group 1 and 51 in group 2. The incisional SSI rate was 10% in group 1 and 35.3% in group 2 (p=0.004; odds ratio [OR]=0.204; 95% confidence interval [CI] 0.069-0.605). A significant reduction in SSIs caused by Escherichia coli and Enterococcus faecalis was observed in group 2.
  
  
  CONCLUSIONS
  The use of triclosan-coated sutures in fecal peritonitis surgery reduces the incidence of incisional SSI.
authors.affiliation: 1 Department of Surgery, Coloproctology Unit, General University Hospital Elche , Alicante, Spain .
authors.forename: Jaime
authors.initials: J
authors.lastname: Ruiz-Tovar
authors.affiliation: 2 Department of Surgery, Coloproctology Unit, University Hospital Son Espases , Mallorca, Spain .
authors.forename: Natalia
authors.initials: N
authors.lastname: Alonso
authors.affiliation: 3 Department of Surgery, Coloproctology Unit, University Hospital Ramon y Cajal , Madrid, Spain .
authors.forename: Vicente
authors.initials: V
authors.lastname: Morales
authors.affiliation: 4 Department of Surgical Nursery, Hospital del Sureste , Madrid, Spain .
authors.forename: Carolina
authors.initials: C
authors.lastname: Llavero
mesh_terms: D034861:Abdominal Wall / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible; D013293:Enterococcus faecalis / Q000302:isolation & purification; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000601:surgery*; D013530:Surgical Wound Infection / Q000453:epidemiology*; D013536:Suture Techniques; D013537:Sutures; D016896:Treatment Outcome; D014260:Triclosan / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D014260:Triclosan