title: Cell-penetrating peptides: strategies for anticancer treatment.
abstract: Cell-penetrating peptides (CPP) provide an efficient strategy for the intracellular delivery of bioactive molecules in various biomedical applications. This review focuses on recent advances in the use of CPPs to deliver anticancer therapeutics and imaging reagents to cancer cells, along with CPP contributions to novel tumor-targeting techniques. CPPs are now used extensively to deliver a variety of therapeutics, despite lacking cell specificity and having a short duration of action. Resolution of these shortcomings to enable increased cancer cell and/or tumor specificity could improve CPP-based drug delivery strategies, expand combined drug delivery possibilities, and strengthen future clinical applications of these peptides.
authors.affiliation: Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address: draucher@umc.edu.
authors.forename: Drazen
authors.initials: D
authors.lastname: Raucher
authors.affiliation: Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA.
authors.forename: Jung Su
authors.initials: JS
authors.lastname: Ryu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D057846:Cell-Penetrating Peptides / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D057846:Cell-Penetrating Peptides
keywords: anticancer; cell-penetrating peptide; elastin-like polypeptide; tumor targeting