title: Elevated Total Iron-Binding Capacity Is Associated with an Increased Risk of Celiac Disease.
abstract: BACKGROUND
  Several lines of evidence suggest that abnormal iron homeostasis may itself play an important role in the development of celiac disease.
  
  
  OBJECTIVE
  We sought to determine whether abnormalities in iron status could be detected prior to the diagnosis of celiac disease, and to understand the relationship between altered iron indices and the natural history of celiac disease.
  
  
  METHODS
  We conducted a case-control study at two major tertiary referral hospitals. Cases were comprised of patients with celiac disease in whom iron status was assessed prior to the diagnosis. Each case was matched to five controls without known gastrointestinal disease according to age and sex. Information on potential covariates and laboratory values within 1, 1-3, and 3-5 years prior to diagnosis was collected. We used conditional logistic regression to evaluate the effect of iron indices on risk of celiac disease.
  
  
  RESULTS
  We identified 157 celiac cases and 695 matched controls. Compared to participants with normal TIBC, the age-adjusted risk of celiac disease was significantly elevated among patients with elevated TIBC. For each 10 μg/dL increase in TIBC, the risk of celiac disease increased by 4.6, 3.8, and 7.9% within 1, 1-3, and 3-5 years prior to diagnosis, respectively. Patients with elevated pre-diagnosis TIBC were more likely to have abnormal liver enzymes and osteoporosis.
  
  
  CONCLUSIONS
  Elevated TIBC is associated with an increased risk of celiac disease. Further investigation into the potential role of altered iron homeostasis may uncover important environmental factors that contribute to the development of celiac disease.
authors.affiliation: Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. dletner@mgh.harvard.edu.
authors.forename: Dorothea
authors.initials: D
authors.lastname: Letner
authors.affiliation: Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. jpeloquin@mgh.harvard.edu.|Department of Medicine, Harvard Medical School, Boston, MA, USA. jpeloquin@mgh.harvard.edu.
authors.forename: Joanna
authors.initials: J
authors.lastname: Peloquin
authors.affiliation: Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. jdurand03@gmail.com.
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: Durand
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham & Women's Hospital, 1620 Tremont Street, BC-3-002EE, Boston, MA, 02120, USA. arutherford@partners.org.|Department of Medicine, Harvard Medical School, Boston, MA, USA. arutherford@partners.org.
authors.forename: Anna
authors.initials: A
authors.lastname: Rutherford
authors.affiliation: Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. vyajnik@mgh.harvard.edu.|Department of Medicine, Harvard Medical School, Boston, MA, USA. vyajnik@mgh.harvard.edu.
authors.forename: Vijay
authors.initials: V
authors.lastname: Yajnik
authors.affiliation: Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. hkhalili@mgh.harvard.edu.|Department of Medicine, Harvard Medical School, Boston, MA, USA. hkhalili@mgh.harvard.edu.
authors.forename: Hamed
authors.initials: H
authors.lastname: Khalili
authors.affiliation: Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. jjgarber@mgh.harvard.edu.|Department of Medicine, Harvard Medical School, Boston, MA, USA. jjgarber@mgh.harvard.edu.
authors.forename: John
authors.initials: J
authors.lastname: Garber
mesh_terms: D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007501:Iron
keywords: Biomarkers; Celiac disease; Iron homeostasis; TIBC