title: Associations of SNPs located at candidate genes to bovine growth traits, prioritized with an interaction networks construction approach.
abstract: BACKGROUND
  For most domestic animal species, including bovines, it is difficult to identify causative genetic variants involved in economically relevant traits. The candidate gene approach is efficient because it investigates genes that are expected to be associated with the expression of a trait and defines whether the genetic variation present in a population is associated with phenotypic diversity. A potential limitation of this approach is the identification of candidates. This study used a bioinformatics approach to identify candidate genes via a search guided by a functional interaction network.
  
  
  RESULTS
  A functional interaction network tool, BosNet, was constructed for Bos taurus. Predictions for candidate genes were performed using the guilt-by-association principle in BosNet. Association analyses identified five novel markers within BosNet-prioritized genes that had significant effects on different growth traits in Charolais and Brahman cattle.
  
  
  CONCLUSIONS
  BosNet is an excellent tool for the identification of single nucleotide polymorphisms that are potentially associated with complex traits.
authors.affiliation: Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica. IPN, Boulevard del Maestro esq. Elías Piña, Col. Narciso Mendoza, Cd. Reynosa, Tam, C.P. 88710, Mexico. biol.curso@gmail.com.
authors.forename: Francisco Alejandro
authors.initials: FA
authors.lastname: Paredes-Sánchez
authors.affiliation: Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica. IPN, Boulevard del Maestro esq. Elías Piña, Col. Narciso Mendoza, Cd. Reynosa, Tam, C.P. 88710, Mexico. asifuentes@ipn.mx.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Sifuentes-Rincón
authors.affiliation: Red de Estudios Moleculares Avanzados, Instituto de Ecología, A.C., Xalapa, Mexico. aldo.segura@inecol.mx.
authors.forename: Aldo
authors.initials: A
authors.lastname: Segura Cabrera
authors.affiliation: Laboratorio de Bioinformática, Centro de Biotecnología Genómica. IPN, Boulevard del Maestro esq. Elías Piña, Col. Narciso Mendoza, Cd. Reynosa, Tam, C.P. 88710, Mexico. cagarcia@ipn.mx.
authors.forename: Carlos Armando
authors.initials: CA
authors.lastname: García Pérez
authors.affiliation: Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica. IPN, Boulevard del Maestro esq. Elías Piña, Col. Narciso Mendoza, Cd. Reynosa, Tam, C.P. 88710, Mexico. gparra@ipn.mx.
authors.forename: Gaspar Manuel
authors.initials: GM
authors.lastname: Parra Bracamonte
authors.affiliation: Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica. IPN, Boulevard del Maestro esq. Elías Piña, Col. Narciso Mendoza, Cd. Reynosa, Tam, C.P. 88710, Mexico. pas122@hotmail.com.
authors.forename: Pascuala
authors.initials: P
authors.lastname: Ambriz Morales
mesh_terms: D000483:Alleles; D000818:Animals; D001947:Breeding; D002417:Cattle; D019295:Computational Biology / Q000379:methods*; D004843:Epistasis, Genetic; D005787:Gene Frequency; D023281:Genomics; D005838:Genotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable