title: Nuclear magnetic resonance: a key metabolomics platform in the drug discovery process.
abstract: Metabolomics is an innovative tool that is now emerging in the drug discovery process. Indeed, its ability to follow the dynamic perturbations in the metabolome resulting from pathologies but also from drug treatment and or/toxicity is of value for the development of new therapeutic approaches. Nuclear magnetic resonance (NMR) spectroscopy, which is an important analytical technique for several steps of the lead discovery, validation and optimization processes, has been described, together with mass spectrometry (MS) as one of the major platform that could be used for metabolomics studies. This review highlights why NMR could be considered a key tool for the application of metabolomics in drug discovery.
authors.affiliation: Center for Interdisciplinary Research on Medicines, Department of Medicinal Chemistry, University of Liège, Liège, Belgium.
authors.forename: Justine
authors.initials: J
authors.lastname: Leenders
authors.affiliation: Center for Interdisciplinary Research on Medicines, Department of Pharmacognosy, University of Liège, Liège, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Frédérich
authors.affiliation: Center for Interdisciplinary Research on Medicines, Department of Medicinal Chemistry, University of Liège, Liège, Belgium. Electronic address: P.deTullio@ulg.ac.be.
authors.forename: Pascal
authors.initials: P
authors.lastname: de Tullio
mesh_terms: D055808:Drug Discovery; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D013058:Mass Spectrometry; D055432:Metabolomics / Q000379:methods*