title: Role of gut microbiota in the modulation of atherosclerosis-associated immune response.
abstract: Inflammation and metabolic abnormalities are linked to each other. At present, pathogenic inflammatory response was recognized as a major player in metabolic diseases. In humans, intestinal microflora could significantly influence the development of metabolic diseases including atherosclerosis. Commensal bacteria were shown to activate inflammatory pathways through altering lipid metabolism in adipocytes, macrophages, and vascular cells, inducing insulin resistance, and producing trimethylamine-N-oxide. However, gut microbiota could also play the atheroprotective role associated with anthocyanin metabolism and administration of probiotics and their components. Here, we review the mechanisms by which the gut microbiota may influence atherogenesis.
authors.affiliation: Department of Molecular Genetic Diagnostics and Cell Biology, Division of Laboratory Medicine, Institute of Pediatrics, Research Center for Children's Health, Moscow Russia ; The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center, Miami Beach, FL USA.
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Chistiakov
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow Russia ; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW Australia ; School of Medicine, University of Western Sydney, Campbelltown, NSW Australia.
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Bobryshev
authors.affiliation: Department of Oral and Diagnostic Sciences, Columbia University, New York, NY USA.
authors.forename: Emil
authors.initials: E
authors.lastname: Kozarov
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow Russia ; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow Russia.
authors.forename: Igor A
authors.initials: IA
authors.lastname: Sobenin
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow Russia ; Institute for Atherosclerosis, Skolkovo Innovation Center, Moscow Russia ; Department of Biophysics, Biological Faculty, Moscow State University, Moscow Russia.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Orekhov
keywords: arteries; atherogenesis; atherosclerosis; immune system; intestinal microbiota