title: Dementia.
abstract: Dementia is a clinical diagnosis requiring new functional dependence on the basis of progressive cognitive decline. It is estimated that 1.3% of the entire UK population, or 7.1% of those aged 65 or over, have dementia. Applying these to 2013 population estimates gives an estimated number of 19,765 people living with dementia in Northern Ireland. The clinical syndrome of dementia can be due to a variety of underlying pathophysiological processes. The most common of these is Alzheimer's disease (50-75%) followed by vascular dementia (20%), dementia with Lewy bodies (5%) and frontotemporal lobar dementia (5%). The clinical symptoms and pathophysiological processes of these diseases overlap significantly. Biomarkers to aid diagnosis and prognosis are emerging. Acetylcholinesterase inhibitors and memantine are the only medications currently licensed for the treatment of dementia. The nature of symptoms mean people with dementia are more dependent and vulnerable, both socially and in terms of physical and mental health, presenting evolving challenges to society and to our healthcare systems.
authors.affiliation: Centre for Public Health, Queen's University Belfast.
authors.forename: E L
authors.initials: EL
authors.lastname: Cunningham
authors.affiliation: Centre for Public Health, Queen's University Belfast ; Belfast Health and Social Care Trust.
authors.forename: B
authors.initials: B
authors.lastname: McGuinness
authors.affiliation: Belfast Health and Social Care Trust.
authors.forename: B
authors.initials: B
authors.lastname: Herron
authors.affiliation: Centre for Public Health, Queen's University Belfast ; Belfast Health and Social Care Trust.
authors.forename: A P
authors.initials: AP
authors.lastname: Passmore
mesh_terms: D015415:Biomarkers; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003704:Dementia / Q000175:diagnosis* / Q000191:economics / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D008559:Memantine / Q000627:therapeutic use; D059906:Neuroimaging; D009660:Northern Ireland / Q000453:epidemiology; D015995:Prevalence; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
chemical_list: D015415:Biomarkers; D002800:Cholinesterase Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; D008559:Memantine