title: Tonic Pupil, a Paraneoplastic Neuro-Ophtalmological Disease Associated with Occult Breast Cancer.
abstract: Here, we present a case of tonic pupil associated with occult breast cancer as a paraneoplastic neuro-ophthalmology syndrome. A 45-year-old woman developed progressive photophobia and blurred vision due to unilateral Adie's tonic pupil. Magnetic resonance image of her brain and neurological examination (including deep tendon reflexes) were normal at first visit. Follow-up examinations performed by ophthalmologist every 6 month without any change in her condition. After 2 years, patient discovered a mass in her breast which identified to be malignant after diagnostic procedures. Despite surgical and medical treatment for cancer, no change in the ocular condition was happened.
authors.affiliation: Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Peyman
authors.affiliation: Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Kabiri
authors.affiliation: Department of Ophthalmology, Faculty of Medicine Building, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Peyman
mesh_terms: D001943:Breast Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D020361:Paraneoplastic Syndromes, Nervous System / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D015845:Tonic Pupil / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome
keywords: Adie's tonic pupil; breast cancer; paraneoplastic syndrome