title: Synthesis of ε-Viniferin Glycosides by Glucosyltransferase from Phytolacca americana and their Inhibitory Activity on Histamine Release from Rat Peritoneal Mast Cells.
abstract: Glycosylation of (+)-ε-viniferin was investigated using glucosyltransferase from Phytolacca americana (PaGT3) as a biocatalyst. (+)-ε-Viniferin was converted by PaGT3 into its 4b- and 13b-β-D-glucosides, the inhibitory activities on histamine release from rat peritoneal mast cells of which were higher than that of (+)-ε-viniferin.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hamada
authors.forename: Hatsuyuki
authors.initials: H
authors.lastname: Hamada
authors.forename: Kei
authors.initials: K
authors.lastname: Shimoda
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis / Q000494:pharmacology*; D055162:Biocatalysis; D002478:Cells, Cultured; D005964:Glucosyltransferases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology*; D006632:Histamine / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology*; D029604:Phytolacca americana / Q000201:enzymology* / Q000235:genetics; D010940:Plant Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013267:Stilbenes / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D001572:Benzofurans; D006027:Glycosides; D010940:Plant Proteins; D013267:Stilbenes; C091891:epsilon-viniferin; D006632:Histamine; D005964:Glucosyltransferases