title: CGRP 4218T/C polymorphism correlated with postoperative analgesic effect of fentanyl.
abstract: OBJECTIVE
  Our study aimed at evaluating the association between α-calcitonin gene-related peptide (CGRP) 4218T/C polymorphism and the patient-controlled analgesic (PCA) effect of fentanyl on Chinese Han population.
  
  
  METHODS
  98 patients were involved in the experiment, but only 92 patients completed the experiment. 0.1 mg/kg fentanyl was given to the patients through intravenous injection ten minutes before the ending of surgery. The patients achieved PCA by controlling the fentanyl infusion pump and a single dose was 1 mg. The CGRP 4218T/C polymorphism was genotyped with polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. The fentanyl consumption within the 72 hours after the surgery was recorded and the pain was assessed with numeric rating scale (NRS) method.
  
  
  RESULTS
  The patients were divided into three groups of wild homozygote (T/T), heterozygote (T/C), and mutant homozygote (C/C). At the 6th hour and the 12th hour after the surgery, the fentanyl consumption for PCA of the T/C group was significantly higher than the T/T group (P<0.05). Meanwhile, the fentanyl consumption of the C/C group was much higher than the T/T group (P<0.05) at the 12th hour and the 24th hour. Besides, the fentanyl consumption of the C/C group was more than the T/C group (P<0.05) at the 24th hour. The differences in NRS scores, Ramsey scores, and postoperative adverse reactions between each group at all time points were not statistically significant.
  
  
  CONCLUSIONS
  CGRP 4218T/C polymorphism may be associated with the postoperative fentanyl consumption for analgesia.
authors.affiliation: Department of Pain, Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Department of Anesthesiology, 401 Hospital of PLA Qingdao 266071, China.
authors.forename: Mingqiang
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pain, Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Fenghe
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Pain, Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pain, Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Pain, Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Junmin
authors.initials: J
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D044466:Asian People / Q000235:genetics; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D000701:Analgesics, Opioid; D015740:Calcitonin Gene-Related Peptide; D005283:Fentanyl
keywords: CGRP; fentanyl; postoperative analgesia