title: Catechol-Functionalized Synthetic Polymer as a Dental Adhesive to Contaminated Dentin Surface for a Composite Restoration.
abstract: This study reports a synthetic polymer functionalized with catechol groups as dental adhesives. We hypothesize that a catechol-functionalized polymer functions as a dental adhesive for wet dentin surfaces, potentially eliminating the complications associated with saliva contamination. We prepared a random copolymer containing catechol and methoxyethyl groups in the side chains. The mechanical and adhesive properties of the polymer to dentin surface in the presence of water and salivary components were determined. It was found that the new polymer combined with an Fe(3+) additive improved bond strength of a commercial dental adhesive to artificial saliva contaminated dentin surface as compared to a control sample without the polymer. Histological analysis of the bonding structures showed no leakage pattern, probably due to the formation of Fe-catechol complexes, which reinforce the bonding structures. Cytotoxicity test showed that the polymers did not inhibit human gingival fibroblast cells proliferation. Results from this study suggest a potential to reduce failure of dental restorations due to saliva contamination using catechol-functionalized polymers as dental adhesives.
authors.affiliation: †Department of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University, Seoul, 03722, Republic of Korea.
authors.forename: Sang-Bae
authors.initials: SB
authors.lastname: Lee
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Cabezas
authors.affiliation: †Department of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University, Seoul, 03722, Republic of Korea.
authors.forename: Kwang-Mahn
authors.initials: KM
authors.lastname: Kim
authors.affiliation: †Department of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University, Seoul, 03722, Republic of Korea.
authors.forename: Kyoung-Nam
authors.initials: KN
authors.lastname: Kim
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kuroda
mesh_terms: D002396:Catechols / Q000138:chemical synthesis / Q000737:chemistry*; D003188:Composite Resins / Q000138:chemical synthesis / Q000737:chemistry; D001840:Dental Bonding; D003738:Dental Cements / Q000138:chemical synthesis / Q000737:chemistry*; D003804:Dentin / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D002396:Catechols; D003188:Composite Resins; D003738:Dental Cements; D008689:Methacrylates; D011108:Polymers; C034221:catechol