title: [Association between acanthosis nigricans and metabolic syndrome in children with obesity].
abstract: OBJECTIVE
  To investigate adipokines levels in obese children with acanthosis nigricans (AN) and to explore the relationship between AN and metabolic syndrome (MS).
  
  
  METHODS
  A cross-sectional study was performed on 109 obese children and 47 age- and gender-matched normal controls. The obese children were divided into two groups with AN and without AN. Serum levels of adiponectin, leptin, TNF-α and retinol-binding protein 4 (RBP4) were measured using ELISA. Multiple logistic regression analysis was performed to estimate the association of clinical parameters with MS.
  
  
  RESULTS
  Waist-hip ratio, systolic blood pressure, triglyceride, fasting insulin and insulin resistance index (HOMA-IR) were significantly higher in obese children with AN than in those without AN and normal controls (P<0.05). The obese children with AN and without AN had lower adiponectin levels than normal controls (P<0.05), on the contrary, the obese children with AN had higher leptin levels than those without AN and normal controls (P<0.05). Multiple logistic regression analysis revealed that AN (OR=3.469, 95%CI: 1.518-7.929) and BMI (OR=7.108, 95%CI: 2.359-21.416) were independent risk factors for MS.
  
  
  CONCLUSIONS
  As a visible marker of insulin resistance, AN is associated with abnormal adipokines secretion. Reducing the incidence of AN and losing weight may prevent obesity associated MS.
authors.affiliation: Department of Pediatrics, Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China. xiaoyanfeng.xjtu@gmail.com.
authors.forename: Xin-Rui
authors.initials: XR
authors.lastname: Tan
authors.forename: Mei-Zhen
authors.initials: MZ
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Xiao
mesh_terms: D000052:Acanthosis Nigricans / Q000097:blood / Q000209:etiology*; D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology*; D009765:Obesity / Q000150:complications*
chemical_list: D052242:Adiponectin; D020738:Leptin