title: Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1.
abstract: Apolipoprotein C1 (ApoC1) is a component of multiple lipoproteins where it performs a variety of roles in lipid metabolism and transport. ApoC1 exists as both full-length and truncated isoforms. Truncation of ApoC1 has been postulated to result from the action of dipeptidyl peptidase-4 (DPP-4), the target of a new class of diabetes drugs that includes sitagliptin phosphate. In this study, we sought to determine if oral administration of sitagliptin altered the proportion of ApoC1 isoforms circulating in humans. Results indicated a dramatic change in ApoC1 truncation, consistent with a high level of DPP-4 inhibition by sitagliptin.
  
  
  BACKGROUND
  University of Minnesota, Minneapolis, MN, USA.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Nicole E B
authors.initials: NE
authors.lastname: Skinner
authors.affiliation: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Wroblewski
authors.affiliation: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Kirihara
authors.affiliation: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Gary L
authors.initials: GL
authors.lastname: Nelsestuen
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, MN, USA. seaqu001@umn.edu.
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Seaquist
keywords: Apolipoprotein C1; Mass spectrometry; Sitagliptin