title: Imaging in Endovascular Stroke Trials.
abstract: Ischemic stroke remains a leading cause of death and disability worldwide. Various endovascular trials have addressed clinical outcomes without elucidating the impact of imaging studies in patient selection. The success of recent endovascular trials was bolstered by the use of advanced imaging techniques for optimal selection of reperfusion candidates. This seminal juncture in the history of stroke trials warrants further consideration on the use of imaging to guide future refinements in the treatment of acute stroke. In this article, we systematically review the imaging methodology and key facets used in all published endovascular stroke trials to date, discuss the success of recent trials using latest advanced imaging techniques and focus on the importance of imaging studies for future patient selection.
authors.affiliation: Allegheny General Hospital, Neurology, Pittsburgh, PA.
authors.forename: Konark
authors.initials: K
authors.lastname: Malhotra
authors.affiliation: Neurovascular Imaging Research Core and the UCLA Stroke Center, Los Angeles, CA.
authors.forename: David S
authors.initials: DS
authors.lastname: Liebeskind
mesh_terms: D002533:Cerebral Angiography / Q000379:methods; D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods; D059906:Neuroimaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020521:Stroke / Q000175:diagnosis* / Q000628:therapy*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
keywords: Neuroimaging; clinical trials; endovascular therapy; stroke