title: Biocompatible hydrodispersible magnetite nanoparticles used as antibiotic drug carriers.
abstract: Here we report a newly synthesized vectorizing nanosystem, based on hydrodispersible magnetite nanoparticles (HMNPs) with an average size less than 10 nm, obtained by precipitation of Fe(II) and Fe(III) in basic solution of p-aminobenzoic acid (PABA), characterized by high-resolution transmission electron microscopy (HR-TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), differential thermal analysis coupled with thermogravimetric analysis (DTA-TGA) and bioevaluated for cytotoxicity and antibiotic delivery in active forms. The obtained data demonstrate that HMNPs can be used as an efficient drug delivery system, for clinically relevant antimicrobial drugs. HMNPs antimicrobial activity depended on the loaded drug structure and the tested microbial strain, being more efficient against Pseudomonas aeruginosa, comparing with the Escherichia coli strain. The novel HMNPs demonstrated an acceptable biocompatibility level, being thus a very good candidate for biomedical applications, such as drug delivery or targeting.
authors.affiliation: Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; danedmih@gmail.com.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bolocan
authors.forename: Dan Eduard
authors.initials: DE
authors.lastname: Mihaiescu
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.forename: Georgeta
authors.initials: G
authors.lastname: Voicu
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
authors.forename: Anton
authors.initials: A
authors.lastname: Ficai
authors.forename: Bogdan Ştefan
authors.initials: BŞ
authors.lastname: Vasile
authors.forename: Coralia
authors.initials: C
authors.lastname: Bleotu
authors.forename: Mariana Carmen
authors.initials: MC
authors.lastname: Chifiriuc
authors.forename: Corina Silvia
authors.initials: CS
authors.lastname: Pop
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001672:Biocompatible Materials / Q000737:chemistry*; D004055:Differential Thermal Analysis; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D010316:Particle Size; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D014867:Water