title: Small RNAs Regulate Primary and Secondary Metabolism in Gram-negative Bacteria.
abstract: Over the last decade, small (often noncoding) RNA molecules have been discovered as important regulators influencing myriad aspects of bacterial physiology and virulence. In particular, small RNAs (sRNAs) have been implicated in control of both primary and secondary metabolic pathways in many bacterial species. This chapter describes characteristics of the major classes of sRNA regulators, and highlights what is known regarding their mechanisms of action. Specific examples of sRNAs that regulate metabolism in gram-negative bacteria are discussed, with a focus on those that regulate gene expression by base pairing with mRNA targets to control their translation and stability.
authors.affiliation: Department of Microbiology, University of Illinois, Urbana, IL 61801.
authors.forename: Maksym
authors.initials: M
authors.lastname: Bobrovskyy
authors.affiliation: Department of Microbiology, University of Illinois, Urbana, IL 61801.
authors.forename: Carin K
authors.initials: CK
authors.lastname: Vanderpool
authors.affiliation: Biological Sciences Department, University of Wisconsin-Parkside, Kenosha, WI 53141.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Richards
mesh_terms: D018407:Bacterial Physiological Phenomena / Q000235:genetics*; D020029:Base Pairing / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D006090:Gram-Negative Bacteria / Q000235:genetics* / Q000378:metabolism*; D008667:Metalloproteins / Q000235:genetics; D053038:Quorum Sensing / Q000235:genetics; D012329:RNA, Bacterial / Q000235:genetics; D058727:RNA, Small Untranslated / Q000235:genetics*; D064210:Secondary Metabolism / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D029968:Escherichia coli Proteins; D008667:Metalloproteins; D012329:RNA, Bacterial; D058727:RNA, Small Untranslated; C510617:YbeY protein, E coli