title: [Why oesophageal adenocarcinoma is occurring more frequently].
abstract: The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk factors that might account for this rising incidence are reflux, obesity and the absence of Helicobacter pylori. Oesophageal adenocarcinoma is 9 times more likely in men than in women. The reason for this much higher incidence of adenocarcinoma in men is still unclear, but sex hormones may play a role.
authors.affiliation: Karolinska Institutet, department of Molecular Medicine and Surgery, Upper Gastrointestinal Surgery, Stockholm, Zweden.
authors.forename: Eva
authors.initials: E
authors.lastname: Doorakkers
authors.forename: Nele
authors.initials: N
authors.lastname: Brusselaers
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D009765:Obesity / Q000150:complications*; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate