title: Evolution of EEG Motor Rhythms after Spinal Cord Injury: A Longitudinal Study.
abstract: Spinal cord injury (SCI) does not only produce a lack of sensory and motor function caudal to the level of injury, but it also leads to a progressive brain reorganization. Chronic SCI patients attempting to move their affected limbs present a significant reduction of brain activation in the motor cortex, which has been linked to the deafferentation. The aim of this work is to study the evolution of the motor-related brain activity during the first months after SCI. Eighteen subacute SCI patients were recruited to participate in bi-weekly experimental sessions during at least two months. Their EEG was recorded to analyze the temporal evolution of the event-related desynchronization (ERD) over the motor cortex, both during motor attempt and motor imagery of their paralyzed hands. The results show that the α and β ERD evolution after SCI is negatively correlated with the clinical progression of the patients during the first months after the injury. This work provides the first longitudinal study of the event-related desynchronization during the subacute phase of spinal cord injury. Furthermore, our findings reveal a strong association between the ERD changes and the clinical evolution of the patients. These results help to better understand the brain transformation after SCI, which is important to characterize the neuroplasticity mechanisms involved after this lesion and may lead to new strategies for rehabilitation and motor restoration of these patients.
authors.affiliation: Dpto. Informática e Ingeniería de Sistemas, University of Zaragoza, Zaragoza, Spain; Instituto de Investigación en Ingeniería de Aragón (I3A), Zaragoza, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: López-Larraz
authors.affiliation: Dpto. Informática e Ingeniería de Sistemas, University of Zaragoza, Zaragoza, Spain; Instituto de Investigación en Ingeniería de Aragón (I3A), Zaragoza, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Montesano
authors.affiliation: Biomechanics and Technical Aids Unit, Hospital Nacional de Parapléjicos, Toledo, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Gil-Agudo
authors.affiliation: Dpto. Informática e Ingeniería de Sistemas, University of Zaragoza, Zaragoza, Spain; Instituto de Investigación en Ingeniería de Aragón (I3A), Zaragoza, Spain; Bit&Brain Technologies SL, Zaragoza, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Minguez
authors.affiliation: FENNSI Group, Hospital Nacional de Parapléjicos, Toledo, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Oliviero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004569:Electroencephalography; D058407:Electroencephalography Phase Synchronization; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000503:physiopathology*; D055815:Young Adult