title: Central Nervous System Involvement as Relapse in Undiagnosed Whipple's Disease with Atypical Symptoms at Onset.
abstract: Whipple's disease (WD) is a rare systemic disease caused by the gram-positive bacillus Tropheryma Whipplei and mostly characterized by arthralgias, chronic diarrhea, weight loss, fever and abdominal pain. Central Nervous System involvement is not uncommon and it may precede other disease manifestations, appear after treatment and improvement of gastrointestinal signs or rarely be the only WD symptom. We report a case in a middle-aged male with unexplained neurological signs and symptoms which were presented as relapse of previously undiagnosed WD with atypical symptoms at onset. After diagnosis confirmation, the patient was appropriately treated which resulted in improvement of major symptoms.
authors.affiliation: Department of Neurology, Aeginition Hospital, Medical School, Athens National & Kapodistrian University, 72-74 Vas. Sofias Avenue, Athens, 115 28, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Zalonis
authors.affiliation: Department of Neurology, Aeginition Hospital, Medical School, Athens National & Kapodistrian University, 72-74 Vas. Sofias Avenue, Athens, 115 28, Greece.
authors.forename: Foteini
authors.initials: F
authors.lastname: Christidi
authors.affiliation: Department of Neurology, Aeginition Hospital, Medical School, Athens National & Kapodistrian University, 72-74 Vas. Sofias Avenue, Athens, 115 28, Greece.
authors.forename: Constantin
authors.initials: C
authors.lastname: Potagas
authors.affiliation: Department of Neurology, Aeginition Hospital, Medical School, Athens National & Kapodistrian University, 72-74 Vas. Sofias Avenue, Athens, 115 28, Greece.
authors.forename: Michalis
authors.initials: M
authors.lastname: Rentzos
authors.affiliation: Department of Neurology, Aeginition Hospital, Medical School, Athens National & Kapodistrian University, 72-74 Vas. Sofias Avenue, Athens, 115 28, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Evdokimidis
authors.affiliation: Department of Neurology, Aeginition Hospital, Medical School, Athens National & Kapodistrian University, 72-74 Vas. Sofias Avenue, Athens, 115 28, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kararizou
keywords: Tropheryma whipplei; central nervous system; relapse; whipple’s disease