title: Effect of Polymer Micelles on Antifungal Activity of Geranylorcinol Compounds against Botrytis cinerea.
abstract: Herein, we explore the potential use of two micelle-forming block copolymers, i.e., Pluronic F-127 and poly(ethylene oxide)-b-poly(caprolactone), for application of fungicide agents. The polymer effect on the in vitro fungicide activity of a series of geranyl orcinol derivatives against Botrytis cinerea has been assessed. The results show that, for all test compounds, the incorporation into micelles, formed by Pluronic F-127, produces a great enhancement of the inhibitory effect on the growth of B. cinerea. For some compounds, at the lowest tested concentration (50 ppm), the percentage of inhibition increases significantly (from 0-10 to 80-90%) when the application is made using a polymer solution instead of an ethanol/water mixture. The synthesis and structural determination of a series of eight geranylphenols/diacetates, which were used as fungicide agents, are also discussed. These results suggest that polymer micelles are promising systems for application of crop-protecting agents.
authors.forename: Lautaro
authors.initials: L
authors.lastname: Taborga
authors.forename: Katy
authors.initials: K
authors.lastname: Díaz
authors.affiliation: §Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, Llano Subercaseaux 2801, Santiago 8320325, Chile.
authors.forename: Andrés F
authors.initials: AF
authors.lastname: Olea
authors.affiliation: ∥Universidad Andres Bello, Quillota 980, Viña del Mar 2520000, Chile.
authors.forename: Paula
authors.initials: P
authors.lastname: Reyes-Bravo
authors.affiliation: ⊥Departamento de Ciencias de los Materiales, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Avenida Tupper 2069, Santiago 8370451, Chile.
authors.forename: Mario E
authors.initials: ME
authors.lastname: Flores
authors.affiliation: #Facultad de Medicina, Universidad de Valparaíso de Chile, Hontaneda 2653, Valparaíso 2340000, Chile.
authors.forename: Hugo
authors.initials: H
authors.lastname: Peña-Cortés
authors.forename: Luis
authors.initials: L
authors.lastname: Espinoza
mesh_terms: D020171:Botrytis / Q000187:drug effects* / Q000254:growth & development; D004337:Drug Carriers / Q000737:chemistry*; D005659:Fungicides, Industrial / Q000737:chemistry* / Q000494:pharmacology*; D008823:Micelles; D020442:Poloxamer / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004337:Drug Carriers; D005659:Fungicides, Industrial; D008823:Micelles; D012118:Resorcinols; D020442:Poloxamer; C005282:orcinol
keywords: Botrytis cinerea; antifungal; linear geranylphenols; polymer micelles; structural determination