title: Insights into vaccine development for acquired immune deficiency syndrome from crystal structures of human immunodeficiency virus-1 gp41 and equine infectious anemia virus gp45.
abstract: An effective vaccine against acquired immune deficiency syndrome is still unavailable after dozens of years of striving. The glycoprotein gp41 of human immunodeficiency virus is a good candidate as potential immunogen because of its conservation and relatively low glycosylation. As a reference of human immunodeficiency virus gp41, gp45 from equine infectious anemia virus (EIAV) could be used for comparison because both wild-type and vaccine strain of EIAV have been extensively studied. From structural studies of these proteins, the conformational changes during viral invasion could be unveiled, and a more effective acquired immune deficiency syndrome vaccine immunogen might be designed based on this information.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
authors.forename: Liangwei
authors.initials: L
authors.lastname: Duan
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
authors.forename: Jiansen
authors.initials: J
authors.lastname: Du
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
authors.forename: Xinqi
authors.initials: X
authors.lastname: Liu
mesh_terms: D016915:AIDS Vaccines; D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control* / Q000821:virology; D000818:Animals; D015700:HIV Envelope Protein gp41 / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D004860:Infectious Anemia Virus, Equine / Q000737:chemistry / Q000276:immunology; D008958:Models, Molecular; D011487:Protein Conformation; D014612:Vaccines / Q000276:immunology; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D015700:HIV Envelope Protein gp41; D014612:Vaccines; D014759:Viral Envelope Proteins; C066797:transmembrane envelope glycoprotein gp45, retrovirus
keywords: EIAV gp45; Env-based immunogen; HIV-1 gp41; MPER; crystal structure; gp140; neutralizing antibodies; vaccine development