title: The Prevalence of Dry Eye Syndrome's and the Likelihood to Develop Sjögren's Syndrome in Taiwan: A Population-Based Study.
abstract: BACKGROUND
  Dry eye syndrome (DES) is one of the key clinical features and possibly an early clinical presentation of Sjögren's syndrome (SS). We explore DES prevalence and assess the likelihood of DES patients to develop SS in Taiwan through the National Health Insurance Research Database (NHIRD).
  
  
  METHODS
  Through a cohort comparison study, longitudinal data from the NHIRD (2000 to 2008) in Taiwan was used to probe the prevalence of DES and the odds that DES patients would later develop SS.
  
  
  RESULTS
  The prevalence of DES in the present study is 4.87%. The incidence rates of developing SS were 4.8% for the DES group and 1.5% for comparison group. The median age and interquartile range of DES and comparison patients was 49.8 (10) and 48.7 (15) years old, respectively. The crude hazard ratio (with 95% confidence interval) for DES patients to develop SS was 3.13 (3.10-3.50) for the DES group, and the adjusted hazard ratio (with 95% confidence interval) was 3.64 (3.43-3.87). The observation period and interquartile range for DES and comparison patients to develop SS later were 1418 (781-2316) versus 1641 (971-2512) days respectively.
  
  
  CONCLUSIONS
  DES patients carried a higher risk for developing SS (hazard ratio 3.13) and presented for SS 3.88 years earlier than comparison group patients in this study.
authors.affiliation: Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110 Taiwan. m701061@gmail.com.|Department of Ophthalmology, Taipei City Hospital, Zhongxiao Branch, Taipei 115, Taiwan. m701061@gmail.com.
authors.forename: Ju-Chuan
authors.initials: JC
authors.lastname: Yen
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. johnhsu129@gmail.com.
authors.forename: Chia-An
authors.initials: CA
authors.lastname: Hsu
authors.affiliation: Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110 Taiwan. jakk88@gmail.com.
authors.forename: Yu-Chuan Jack
authors.initials: YC
authors.lastname: Li
authors.affiliation: Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110 Taiwan. 701056@gmail.com.|Ministry of Health and Welfare, Taipei 115, Taiwan. 701056@gmail.com.
authors.forename: Min-Huei
authors.initials: MH
authors.lastname: Hsu
mesh_terms: D000328:Adult; D015331:Cohort Studies; D015352:Dry Eye Syndromes / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012306:Risk; D012859:Sjogren's Syndrome / Q000209:etiology*; D013624:Taiwan / Q000453:epidemiology
keywords: National Health Insurance Research Database (NHIRD); Sjögren’s syndrome (SS); dry eye syndrome (DES); prevalence