title: [Neuronavigation-guided pure endoscopic endonasai transsphenoidal approach for pituitary adenomas].
abstract: OBJECTIVE
  To explore the efficacies of neuronavigation-guided pure endoscopic endonasal transsphenoidal approach for removing pituitary adenomas.
  
  
  METHODS
  Retrospective analyses were conducted for the clinical data of 139 patients undergoing pure endoscopic endonasal transsphenoidal surgery for pituitary adenomas between July 2011 and July 2014. There were 55 males and 84 females with a mean age of 48. 9 (21 - 73) years. The classifications of Hardy-Wilson were I (n =16), II (n = 39), III (n = 48) and IV (n = 36). Neuronavigation was used in all patients. And neuro-ophthalmological, neuroimaging and endocrinological follow-ups were conducted postoperatively.
  
  
  RESULTS
  Total (n = 95, 68. 3%), subtotal (n = 33, 23. 7%) and partial (n = 11, 7. 9%) removals were achieved. For Hardy-Wilson I, gross total removal was achieved (n = 16, 100%); Hardy-Wilson II (n = 35, 89. 7%), Hardy-Wilson III (n = 34, 70. 8%) and Hardy-Wilson IV (n = 10, 27. 8%). Postoperative visual acuity improved (92. 1%, 70/76) and endocrine remission was observed (59. 6%, 53/89). The postoperative complications included cerebrospinal fluid (CSF) leakage (n = 8, 5. 8%), meningitis (n = 3), sellar hematoma (n = 5) and delayed carotid artery rupture (n = 1). And the patient of hemorrhagic shock underwent emergency interventional procedures and was discharged successfully.
  
  
  CONCLUSIONS
  Pure endoscopic endonasal transsphenoidal approach for removing pituitary adenoma is both safe and effective. And its efficacies may further increased through combined neuronavigation.
authors.forename: Changchen
authors.initials: C
authors.lastname: Hu
authors.forename: Hongming
authors.initials: H
authors.lastname: Ji
authors.forename: Shiyuan
authors.initials: S
authors.lastname: Zhang
authors.forename: Xudong
authors.initials: X
authors.lastname: Hao
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.forename: Luhai
authors.initials: L
authors.lastname: Su
mesh_terms: D000236:Adenoma; D000328:Adult; D000368:Aged; D065634:Cerebrospinal Fluid Leak; D005260:Female; D006801:Humans; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D038361:Neuronavigation; D009666:Nose; D010911:Pituitary Neoplasms; D011183:Postoperative Complications; D011184:Postoperative Period; D012189:Retrospective Studies; D055815:Young Adult