title: Primary micropapillary carcinoma of the colon: a case report and literature review.
abstract: We report a case of micropapillary carcinoma (MPC) of the transverse colon. A 56-year-old woman was admitted to our hospital with hematochezia. A lower gastrointestinal examination revealed an irregular ulcerative tumor of approximately 60 mm diameter with marginal elevation in the transverse colon. Abdominal computed tomography showed multiple swollen lymph nodes. A histological examination of the resected specimen revealed that cancer cells had invaded the subserosa. Microscopically, small papillary cells proliferated with lacuna spaces and the cribriform glandular configuration was observed. Immunohistochemically, the basal surface of the neoplastic cell clusters was diffusely positive for MUC1. No primary tumor was observed except for the colon. Therefore, this tumor was diagnosed as a primary MPC of the colon. Since a colorectal MPC was first reported in 2005, seven case reports and three pathological reviews have been presented in the English literature. MPC has an aggressive behavior with a high incidence of lymphovascular invasion and nodal metastases. We should take intensive chemotherapy for colorectal MPC into account, even if surgical resection is curative.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Doi
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. konishimd@med.showa-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Konishi
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Omori
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Yanagawa
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Katagiri
authors.affiliation: Department of Pathology, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Yamochi
authors.affiliation: Department of Pathology, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Date
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Kubota
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Muramoto
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yano
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tojo
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Konda
authors.affiliation: Division of Gastroenterological Surgery, Department of Surgery, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Murakami
authors.affiliation: Endoscopic Center, Showa University Hospital, Tokyo, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Yoshikawa
authors.affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Imawari
keywords: Colorectal carcinoma; Lymph node metastasis; Micropapillary carcinoma