title: A Robust e-Epidemiology Tool in Phenotyping Heart Failure with Differentiation for Preserved and Reduced Ejection Fraction: the Electronic Medical Records and Genomics (eMERGE) Network.
abstract: Identifying populations of heart failure (HF) patients is paramount to research efforts aimed at developing strategies to effectively reduce the burden of this disease. The use of electronic medical record (EMR) data for this purpose is challenging given the syndromic nature of HF and the need to distinguish HF with preserved or reduced ejection fraction. Using a gold standard cohort of manually abstracted cases, an EMR-driven phenotype algorithm based on structured and unstructured data was developed to identify all the cases. The resulting algorithm was executed in two cohorts from the Electronic Medical Records and Genomics (eMERGE) Network with a positive predictive value of >95 %. The algorithm was expanded to include three hierarchical definitions of HF (i.e., definite, probable, possible) based on the degree of confidence of the classification to capture HF cases in a whole population whereby increasing the algorithm utility for use in e-Epidemiologic research.
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA. bielinski.suzette@mayo.edu.
authors.forename: Suzette J
authors.initials: SJ
authors.lastname: Bielinski
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Jyotishman
authors.initials: J
authors.lastname: Pathak
authors.affiliation: Group Health Research Institute, Seattle, WA, 98101, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Carrell
authors.affiliation: Department of Medicine, Division of Primary Care Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Paul Y
authors.initials: PY
authors.lastname: Takahashi
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Janet E
authors.initials: JE
authors.lastname: Olson
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Nicholas B
authors.initials: NB
authors.lastname: Larson
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Hongfang
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Sunghwan
authors.initials: S
authors.lastname: Sohn
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, TN, 37232, USA.
authors.forename: Quinn S
authors.initials: QS
authors.lastname: Wells
authors.affiliation: Departments of Biomedical Informatics and Medicine, Vanderbilt University, Nashville, TN, 37232, USA.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Denny
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Rasmussen-Torvik
authors.affiliation: Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
authors.forename: Jennifer Allen
authors.initials: JA
authors.lastname: Pacheco
authors.affiliation: Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Jackson
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Lesnick
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Gullerud
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Decker
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, MN, 55905, USA.
authors.forename: Naveen L
authors.initials: NL
authors.lastname: Pereira
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Euijung
authors.initials: E
authors.lastname: Ryu
authors.affiliation: Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, 54449, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Dart
authors.affiliation: Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI, 54449, USA.
authors.forename: Peggy
authors.initials: P
authors.lastname: Peissig
authors.affiliation: Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI, 54449, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Linneman
authors.affiliation: Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Gail P
authors.initials: GP
authors.lastname: Jarvik
authors.affiliation: Group Health Research Institute, Seattle, WA, 98101, USA.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Larson
authors.affiliation: The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA, 17822, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Bock
authors.affiliation: The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA, 17822, USA.
authors.forename: Gerard C
authors.initials: GC
authors.lastname: Tromp
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
authors.forename: Mariza
authors.initials: M
authors.lastname: de Andrade
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.|Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, MN, 55905, USA.
authors.forename: Véronique L
authors.initials: VL
authors.lastname: Roger
mesh_terms: D000465:Algorithms; D057225:Data Mining / Q000379:methods*; D057286:Electronic Health Records; D005260:Female; D006333:Heart Failure / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009323:Natural Language Processing; D010641:Phenotype; D015203:Reproducibility of Results; D013318:Stroke Volume; D014481:United States / Q000453:epidemiology; D016277:Ventricular Function, Left
keywords: Electronic medical records; Heart failure; Natural language processing; Phenotyping; Ventricular ejection fraction