title: Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis.
abstract: Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2years (SD 10.2), 39.2% female) were classified as having normal (<5.0mg/μl, N=159) or high CRP levels (>5.0mg/μl, N=91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (β=.155, p=.01) after adjustment for confounding variables. Female gender (β=.229, p=.001), waist circumference (β=.205, p=.003) and non-white ethnicity (β=.181, p=.005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels.
authors.affiliation: Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, United Kingdom. Electronic address: brendonstubbs@hotmail.com.
authors.forename: Brendon
authors.initials: B
authors.lastname: Stubbs
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
authors.forename: Poonam
authors.initials: P
authors.lastname: Gardner-Sood
authors.affiliation: Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; South London and Maudsley NHS Foundation Trust, London, United Kingdom.
authors.forename: Shubulade
authors.initials: S
authors.lastname: Smith
authors.affiliation: Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; King's College Hospital NHS Foundation Trust, United Kingdom.
authors.forename: Khalida
authors.initials: K
authors.lastname: Ismail
authors.affiliation: School of Psychology, University of Sussex, Brighton and Early Intervention in Psychosis Service, Sussex Partnership NHS Foundation Trust, West Sussex, United Kingdom.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Greenwood
authors.affiliation: Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, United Kingdom.
authors.forename: Ross
authors.initials: R
authors.lastname: Farmer
authors.affiliation: National Psychosis Service, South London and Maudsley NHS Foundation Trust, United Kingdom; Institute of Psychiatry, Psychology and Neuroscience and the Biomedical Research Centre, BRC Nucleus, United Kingdom.
authors.forename: Fiona
authors.initials: F
authors.lastname: Gaughran
mesh_terms: D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000453:epidemiology / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000453:epidemiology / Q000503:physiopathology*; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000453:epidemiology / Q000503:physiopathology*; D012044:Regression Analysis; D012559:Schizophrenia / Q000453:epidemiology / Q000503:physiopathology*; D057185:Sedentary Behavior / Q000208:ethnology; D012727:Sex Characteristics; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: C-reactive protein; Cardiovascular disease; Inflammation; Psychosis; Schizophrenia; Sedentary behaviour