title: Relation of metabolic syndrome with endometrial pathologies in patients with abnormal uterine bleeding.
abstract: OBJECTIVE
  We aimed to investigate the association of metabolic syndrome and metabolic risk factors with endometrial hyperplasia and carcinoma among women with abnormal uterine bleeding (AUB).
  
  
  METHODS
  This study included 199 patients who had undergone endometrial curettage due to abnormal uterine bleeding. We divided the patients into two groups according to whether they had an abnormal (n = 53) or normal endometrium (n = 146). Waist circumference, blood pressure, fasting glucose and serum lipid levels were measured and statistically analyzed. The women in each group were matched with regard to mean age, gravidity, parity and menopausal status.
  
  
  RESULTS
  We found increased prevalence of metabolic syndrome, diabetes, general and abdominal obesity, hypertension, elevated levels of glucose, total cholesterol and LDL-cholesterol and reduced levels of HDL-cholesterol among women with endometrial carcinoma and hyperplasia. These results were detected particularly in postmenopausal (>50 years) women compared to pre-menopausal cases (<50 years). All metabolic parameters were similar between hyperplasia and cancer groups.
  
  
  CONCLUSIONS
  Metabolic syndrome and its components have been shown to have profound impacts on initiation and progession of endometrial pathology, particularly during post-menopausal period.
authors.affiliation: a Deparment of Obstetrics and Gynecology , School of Medicine, Medipol University , Istanbul , Turkey .
authors.forename: Suna
authors.initials: S
authors.lastname: Özdemir
authors.affiliation: b Department of Obstetrics and Gynecology , School of Medicine, Bezmialem Vakif University , Istanbul , Turkey .
authors.forename: Gonca
authors.initials: G
authors.lastname: Batmaz
authors.affiliation: b Department of Obstetrics and Gynecology , School of Medicine, Bezmialem Vakif University , Istanbul , Turkey .
authors.forename: Seda
authors.initials: S
authors.lastname: Ates
authors.affiliation: c Department of Obstetrics and Gynecology , School of Medicine, Selcuk University , Konya , Turkey , and.
authors.forename: Cetin
authors.initials: C
authors.lastname: Celik
authors.affiliation: c Department of Obstetrics and Gynecology , School of Medicine, Selcuk University , Konya , Turkey , and.
authors.forename: Feyzanur
authors.initials: F
authors.lastname: Incesu
authors.affiliation: d Department of Internal Medicine , School of Medicine, Bezmialem Vakif University , Istanbul , Turkey.
authors.forename: Celalettin
authors.initials: C
authors.lastname: Peru
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000378:metabolism; D004714:Endometrial Hyperplasia / Q000453:epidemiology* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism; D056128:Obesity, Abdominal / Q000453:epidemiology* / Q000378:metabolism; D016017:Odds Ratio; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D014592:Uterine Hemorrhage / Q000453:epidemiology* / Q000473:pathology
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL
keywords: Endometrium; metabolic syndrome; pathology; uterine bleeding