title: A case report of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and literature review.
abstract: Osteoclast-like giant cell tumors rarely arise in the pancreas. Here we report the case of a 78-year-old woman who was diagnosed with a well-defined 3 cm multilocular mass in the pancreatic body by the use of ultrasonography, computed tomography and magnetic resonance imaging. The rim and the septa of the tumor were well enhanced. The distal pancreas was removed with the spleen and the peripancreatic lymph nodes. Macroscopically, the mass was composed predominantly of a multilocular cystic tumor filled with hemorrhagic necrosis, and partly composed of solid components. A histopathological study showed a proliferation of multinucleated osteoclast-like giant cells and spindle cells. Although the predominant tumor cells were strongly positive for vimentin and CD68 and negative for epithelial markers, there were some sparsely scattered cytokeratin-positive neoplastic glands. Seventeen months after surgery, the patient is still alive and has had no recurrence. Below we review 32 cases of osteoclast-like giant cell tumor of the pancreas that have been reported in English literature since 2000.
authors.affiliation: Department of Surgery, Kamitsuga General Hospital, 1-1033 Shimota, Kanuma, Tochigi, 322-8550, Japan. tenriver@kamituga-hp.or.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Togawa
authors.affiliation: Department of Surgery, Saitama Red Cross Hospital, 8-3-33 Kamiochiai, Chuou, Saitama, Saitama, 338-8553, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tonouchi
authors.affiliation: Department of Surgery, Kamitsuga General Hospital, 1-1033 Shimota, Kanuma, Tochigi, 322-8550, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Chiku
authors.affiliation: Department of Surgery, Kamitsuga General Hospital, 1-1033 Shimota, Kanuma, Tochigi, 322-8550, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Sano
authors.affiliation: Department of Surgery, Kamitsuga General Hospital, 1-1033 Shimota, Kanuma, Tochigi, 322-8550, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Doki
authors.affiliation: Department of Surgery, Kamitsuga General Hospital, 1-1033 Shimota, Kanuma, Tochigi, 322-8550, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yano
authors.affiliation: Department of Surgery, Kamitsuga General Hospital, 1-1033 Shimota, Kanuma, Tochigi, 322-8550, Japan.
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Uno
authors.affiliation: Department of Surgery, Kamitsuga General Hospital, 1-1033 Shimota, Kanuma, Tochigi, 322-8550, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Muronoi
authors.affiliation: Department of Radiology, Kamitsuga General Hospital, 1-1033 Shimota, Kanuma, Tochigi, 322-8550, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kaneoya
authors.affiliation: Department of Gastroenterology, Kamitsuga General Hospital, 1-1033, Shimota, Kanuma, Tochigi, 322-8550, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shinagawa
authors.affiliation: Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou, Chiba, Chiba, 260-8677, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harigaya
authors.affiliation: Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou, Chiba, Chiba, 260-8677, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Toyoda
keywords: Osteoclast-like giant cells; Pancreas; Undifferentiated carcinoma