title: Primary mediastinal large B-cell lymphoma arising from thyroid in a renal recipient with Hashimoto's thyroiditis.
abstract: Primary mediastinal large B-cell lymphoma is a subtype of diffuse large B-cell lymphoma, arising in the mediastinum from putative thymic B-cell origin with distinctive clinical and genetic features. Generally, primary mediastinal large B-cell lymphoma is believed as only deriving in the mediastinum. The current study presents a rare case of primary mediastinal large B-cell lymphoma which arising from thyroid in a renal recipient with Hashimoto's thyroiditis. Moreover, we devoted a discussion to the relationship among primary mediastinal large B-cell lymphoma, immunomodulatory therapy and autoimmune diseases. The immunologic derangement induced by long-term immunomodulatory therapy and Hashimoto's thyroiditis may be the possible cause for the ectopic lymphoma.
authors.affiliation: Department of Oncology, The Second Xiangya Hospital of Central South University China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Oncology, The Second Xiangya Hospital of Central South University China.
authors.forename: Lu
authors.initials: L
authors.lastname: Qu
authors.affiliation: Department of Pathology, The Second Xiangya Hospital of Central South University China.
authors.forename: Dai-Qiang
authors.initials: DQ
authors.lastname: Li
authors.affiliation: Department of Oncology, The Second Xiangya Hospital of Central South University China.
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Hu
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D050031:Hashimoto Disease / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D013934:Thymectomy; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D007166:Immunosuppressive Agents
keywords: Hashimoto’s thyroiditis; Primary mediastinal large B-cell lymphoma; immunologic derangement; organ transplantation; thyroid