title: Headless Myo10 is a regulator of microtubule stability during neuronal development.
abstract: Stabilized microtubules are required for neuronal morphogenesis and migration. However, the underlying mechanism is not fully understood. In this study, we demonstrate that myosin X (Myo10), which is composed of full-length myosin X (fMyo10) and headless myosin X (hMyo10), is important for axon development. fMyo10 is involved in axon elongation, whereas hMyo10 is critical for Tau-1 positive axon formation through stabilizing microtubules. Furthermore, in vivo studies reveal that hMyo10-mediated microtubule stability has a profound effect on both neuronal migration and dendritic arborization in the mammalian cerebral cortex. Taken together, our findings suggest that hMyo10 is involved in neuronal development both in vitro and in vivo by regulating microtubule stability.
authors.affiliation: Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, Jilin, China.
authors.forename: Huali
authors.initials: H
authors.lastname: Yu
authors.affiliation: Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, Jilin, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Sun
authors.affiliation: Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, Jilin, China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Physical Education, Changchun Normal University, Changchun, Jilin, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Lan
authors.affiliation: Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, Jilin, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Fan
authors.affiliation: Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, Jilin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Weixiang
authors.initials: W
authors.lastname: Guo
authors.affiliation: Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, Jilin, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D003712:Dendrites / Q000502:physiology; D018274:Electroporation; D005260:Female; D051379:Mice; D008870:Microtubules / Q000502:physiology*; D009218:Myosins / Q000502:physiology*; D055495:Neurogenesis / Q000235:genetics; D009474:Neurons / Q000502:physiology*; D011247:Pregnancy; D014162:Transfection
chemical_list: C409064:Myo10 protein, mouse; D009218:Myosins
keywords: apical dendrite; axon; full-length myosin X; headless myosin X; microtubule stability; neuronal migration