title: Statistical Physics Methods Provide the Exact Solution to a Long-Standing Problem of Genetics.
abstract: Analytic and computational methods developed within statistical physics have found applications in numerous disciplines. In this Letter, we use such methods to solve a long-standing problem in statistical genetics. The problem, posed by Haldane and Waddington [Genetics 16, 357 (1931)], concerns so-called recombinant inbred lines (RILs) produced by repeated inbreeding. Haldane and Waddington derived the probabilities of RILs when considering two and three genes but the case of four or more genes has remained elusive. Our solution uses two probabilistic frameworks relatively unknown outside of physics: Glauber's formula and self-consistent equations of the Schwinger-Dyson type. Surprisingly, this combination of statistical formalisms unveils the exact probabilities of RILs for any number of genes. Extensions of the framework may have applications in population genetics and beyond.
authors.affiliation: Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS), CNRS and Univ Paris-Sud, UMR 8626, F-91405 Orsay, France.|Max Planck Institute for Mathematics in the Sciences, 04103 Leipzig, Germany.|The Abdus Salam International Centre for Theoretical Physics, Trieste 34151, Italy.
authors.forename: Areejit
authors.initials: A
authors.lastname: Samal
authors.affiliation: INRA, UMR 0320/UMR 8120 Génétique Quantitative et Evolution-Le Moulon, F-91190 Gif-sur-Yvette, France.
authors.forename: Olivier C
authors.initials: OC
authors.lastname: Martin
mesh_terms: D005838:Genotype; D008957:Models, Genetic; D013223:Statistics as Topic / Q000379:methods*