title: [Significance of P504s in distinction between solid pseudopapillary tumor of pancreas and pancreatic neuroendocrine tumors].
abstract: OBJECTIVE
  To study the significance of P504s in differential diagnosis between solid pseudopapillary tumor of the pancreas (SPTP) and pancreatic neuroendocrine tumors (PanNET).
  
  
  METHODS
  Forty-three patients with SPTP and 41 patients with PanNET encountered during the period from 2007 to 2014 were recruited. Immunohistochemical study for vimentin, CD10, chromogranin A, synaptophysin, beta-catenin, CD99 and P504s in SPTP and PanNET was performed. The diagnostic value of P504s in differentiating SPTP from PanNET was analyzed.
  
  
  RESULTS
  Immunohistochemical study showed that vimentin, CD10, chromogranin A, synaptophysin and CD99 were expressed both in SPTP and PanNET. All cases of SPTP showed granular cytoplasmic expression of P504s, whereas those of PanNET were negative.
  
  
  CONCLUSIONS
  P504s is a sensitive and useful marker for SPTP and can be used in the distinction between SPTP and PanNET.
authors.affiliation: Department of Pathology, Jinhua Municipal Central Hospital, Jinhua 321000, China.
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Chen
authors.affiliation: E-mail: zyq10311@126.com.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Shi
authors.forename: Lixiong
authors.initials: L
authors.lastname: Ying
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhai
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Fu
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Liu
authors.forename: Shanxian
authors.initials: S
authors.lastname: Lou
mesh_terms: D000071443:12E7 Antigen / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002291:Carcinoma, Papillary / Q000737:chemistry* / Q000175:diagnosis; D053379:Chromogranin A / Q000032:analysis; D003593:Cytoplasm; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D015260:Neprilysin / Q000032:analysis; D018358:Neuroendocrine Tumors / Q000737:chemistry* / Q000175:diagnosis; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000175:diagnosis; D019998:Racemases and Epimerases / Q000032:analysis*; D016708:Synaptophysin / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D051176:beta Catenin / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; C495270:CTNNB1 protein, human; D053379:Chromogranin A; D016708:Synaptophysin; D014746:Vimentin; D051176:beta Catenin; D015260:Neprilysin; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase