title: Serum Chemerin Levels in relation to Osteoporosis and Bone Mineral Density: A Case-Control Study.
abstract: BACKGROUND
  To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD).
  
  
  METHODS
  An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate the relationship between serum chemerin levels and BMD.
  
  
  RESULTS
  There were 93 patients included in the osteoporosis group and 93 matched controls. Serum chemerin level was significantly higher in patients with osteoporosis (87.27 ± 5.80 ng/mL) than patients in control (71.13 ± 5.12 ng/mL) (P < 0.01). There was a negative correlation between femoral bone mineral density and chemerin in both groups (R = -0.395, P < 0.01 in osteoporosis group; R = -0.680, P < 0.01 in control) and also a negative correlation between lumbar bone mineral density with chemerin in both groups (R = -0.306, P < 0.01 in osteoporosis group; R = -0.362, P < 0.01 in control).
  
  
  CONCLUSIONS
  Patients with osteoporosis presented a higher level of serum chemerin, which witnessed an inverse correlation with BMD. Further studies are needed to explore the role of chemerin in the pathophysiology of osteoporosis.
authors.affiliation: Department of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Li
authors.affiliation: Department of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Xu
authors.affiliation: Department of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Sun
authors.affiliation: College of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Shan
mesh_terms: D000368:Aged; D015519:Bone Density; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human