title: A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy.
abstract: Novel core-shell tumor-penetrating vesicles consisting of a nanovesicle core with tumor-penetrating ligands and enzymatically degradable polymeric peptides anchored covalently to the core to form a thin polymeric shell are evaluated as drug-delivery systems. This delivery platform demonstrates an enhanced therapeutic efficacy attributed to the synergistic contributions from matrix metalloproteinase (MMP)-responsive drug release as well as improved tumor accumulation and penetration in the tumor microenvironment.
authors.affiliation: College of Marine Life Science, Ocean University of China, No. 5 Yushan Road, Qingdao, P. R. China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, P. R. China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, P. R. China.
authors.forename: Zeng-Ying
authors.initials: ZY
authors.lastname: Qiao
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, P. R. China.
authors.forename: Guo-Bin
authors.initials: GB
authors.lastname: Qi
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, P. R. China.
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
authors.affiliation: College of Marine Life Science, Ocean University of China, No. 5 Yushan Road, Qingdao, P. R. China.
authors.forename: Xi-Guang
authors.initials: XG
authors.lastname: Chen
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D005260:Female; D019073:HT29 Cells; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry; D059016:Tumor Microenvironment
chemical_list: D057846:Cell-Penetrating Peptides; D004337:Drug Carriers; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid
keywords: drug delivery; peptides; polymers; self-assembly