title: Facile access to a heterocyclic, sp(3)-rich chemical scaffold via a tandem condensation/intramolecular nitrone-alkene [3+2] cycloaddition strategy.
abstract: A heterocyclic, sp(3)-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone-alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK. robert.stockman@nottingham.ac.uk.
authors.forename: M J
authors.initials: MJ
authors.lastname: Rawling
authors.forename: T E
authors.initials: TE
authors.lastname: Storr
authors.forename: W A
authors.initials: WA
authors.lastname: Bawazir
authors.forename: S J
authors.initials: SJ
authors.lastname: Cully
authors.forename: W
authors.initials: W
authors.lastname: Lewis
authors.forename: M S I T
authors.initials: MS
authors.lastname: Makki
authors.forename: I R
authors.initials: IR
authors.lastname: Strutt
authors.forename: G
authors.initials: G
authors.lastname: Jones
authors.forename: D
authors.initials: D
authors.lastname: Hamza
authors.forename: R A
authors.initials: RA
authors.lastname: Stockman
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D061565:Cycloaddition Reaction; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry*
chemical_list: D000475:Alkenes; D006571:Heterocyclic Compounds; D009589:Nitrogen Oxides; C015388:nitrones