title: Prediction of short- and long-term outcome in patients with autoimmune hepatitis.
abstract: Autoimmune hepatitis (AIH) is a chronic inflammatory disease characterized by a loss of tolerance toward the hepatocellular epithelium. Liver transplantation (LT) represents the ultimate therapeutic option for a fulminant course or end-stage liver disease. The aim of this study was to elucidate the clinical, serological, and genetic features of remission, relapse, and overall and LT-free survival. Between 2000 and 2014, 354 AIH patients from Hannover Medical School were included. Clinical, laboratory, and histological reports were analyzed. DRB1 allele analyses were performed in 264 AIH and 399 non-AIH patients. Cox's regression analysis was performed to identify factors significantly associated with survival. Patients diagnosed in childhood were at higher risk for relapses (P=0.003), requirement for LTs (P=0.014, log rank), and had a reduced life expectancy (P<0.001, log rank). Detection of soluble liver antigen/liver pancreas antigen (SLA/LP) antibodies was significantly associated with reduced overall and LT-free survival (P=0.037; P=0.021). Cirrhosis, which was evident in 25% at first diagnosis, was found to be a predictor of poor survival and requirement for LT (P=0.003; P=0.009). DRB1*04:01-positive phenotype was associated with a higher rate of complete remissions and with a lower frequency of cirrhosis and LTs. There were no significant differences for subsequent relapses or survival in patients achieving either partial or complete remission.
  
  
  CONCLUSIONS
  Diagnosis<18 years, histological cirrhosis at first diagnosis and SLA/LP antibodies are major risk factors for a poor short- and long-term outcome. These patients are in need of high surveillance. Separating patients with positive SLA/LP antibodies into a third group may be reconsidered. DRB1*04:01 positivity has been identified in association with a favorable clinical outcome.
authors.affiliation: Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.
authors.forename: Martha M
authors.initials: MM
authors.lastname: Kirstein
authors.affiliation: Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Metzler
authors.affiliation: Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Geiger
authors.affiliation: Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.
authors.forename: Eyk
authors.initials: E
authors.lastname: Heinrich
authors.affiliation: Hannover Medical School, Institute for Transfusion Medicine, Hannover, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Hallensleben
authors.affiliation: Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Manns
authors.affiliation: Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.
authors.forename: Arndt
authors.initials: A
authors.lastname: Vogel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001324:Autoantigens / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D019693:Hepatitis, Autoimmune / Q000401:mortality* / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012008:Recurrence
chemical_list: D001324:Autoantigens; C046431:liver antigen LA-1