title: [Analysis of early lactate clearance rate in prognosis of neural function of patients with cardiac arrest].
abstract: OBJECTIVE
  To explore the correlations between early lactate clearance and the prognosis of neural function of patients with cardiac arrest (CA).
  
  
  METHODS
  The total number of patients with CA and restored spontaneous circulation was 74. Their general clinical data such as gender, age, cause of CA, heart rhythm pre-CA, CA duration, resuscitation time, Apache II score, mean arterial pressure (MAP) and presence or absence of convulsion or central hyperthermia were recorded. The levels of lactate at admission and after 6 h's therapy were also collected and used for calculating the 6 h lactate clearance rate for each patient. According to the cerebral performance category, they were divided into two groups of better neural function (CPC1-2, A, n = 24) and worse neural function (CPC3-5, B, n = 50). General clinical data, lactate level and lactate clearance rate of two groups were compared to determine whether or not there was a significant difference. Logistic regression analysis was also used to select independent prognostic factors of neural function.
  
  
  RESULTS
  No significant differences existed in gender, age, cause of CA, heart rhythm before CA, Apache II score, MAP, number of cases with concurrent convulsion or central hyperthermia (P > 0.05). And CA duration and save resuscitation time had significant inter-group differences (7.92 vs 11.16, 17.47 vs 23.80, P < 0.05). The lactate level at admission had no significant inter-group difference (10.7 vs 11.2, P > 0.05) while the 6 h's lactate level of group A was significantly less than that of group B (7.05 vs 5.26, P < 0.05). And the 6 h lactate clearance rate in group A was also significant higher than that in group B (48.79% vs 33.67%, P < 0.05). Logistic regression analysis revealed that 6 h lactate clearance rate and CA duratio were independent prognostic factors for neurological function in post-cardiac arrest patients.
  
  
  CONCLUSIONS
  Early lactate clearance may be associated with the prognosis of neural function for CA patients.
authors.affiliation: Intensive Care Unit, Zhenjiang First People's Hospital, Zhenjiang 212002, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Intensive Care Unit, Zhenjiang First People's Hospital, Zhenjiang 212002, China; Email: jinzc57@163.com.
authors.forename: Zhaochen
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Intensive Care Unit, Zhenjiang First People's Hospital, Zhenjiang 212002, China.
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Intensive Care Unit, Zhenjiang First People's Hospital, Zhenjiang 212002, China.
authors.forename: Lisheng
authors.initials: L
authors.lastname: Tao
mesh_terms: D006323:Heart Arrest; D006801:Humans; D019344:Lactic Acid; D008657:Metabolic Clearance Rate; D011379:Prognosis; D012151:Resuscitation
chemical_list: D019344:Lactic Acid