title: Diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal staging in lung cancer.
abstract: OBJECTIVE
  Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic test with a high diagnostic yield for suspicious central pulmonary lesions and for mediastinal lymph node staging. The main objective of this study was to describe the diagnostic yield of EBUS-TBNA for mediastinal lymph node staging in patients with suspected lung cancer.
  
  
  METHODS
  Prospective study of patients undergoing EBUS-TBNA for diagnosis. Patients ≥ 18 years of age were recruited between July of 2010 and August of 2013. We recorded demographic variables, radiological characteristics provided by axial CT of the chest, location of the lesion in the mediastinum as per the International Association for the Study of Lung Cancer classification, and definitive diagnostic result (EBUS with a diagnostic biopsy or a definitive diagnostic method).
  
  
  RESULTS
  Our analysis included 354 biopsies, from 145 patients. Of those 145 patients, 54.48% were male. The mean age was 63.75 years. The mean lymph node size was 15.03 mm, and 90 lymph nodes were smaller than 10.0 mm. The EBUS-TBNA method showed a sensitivity of 91.17%, a specificity of 100.0%, and a negative predictive value of 92.9%. The most common histological diagnosis was adenocarcinoma.
  
  
  CONCLUSIONS
  EBUS-TBNA is a diagnostic tool that yields satisfactory results in the staging of neoplastic mediastinal lesions.
authors.affiliation: Universidad del Desarrollo, Santiago, Chile.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Fernández-Bussy
authors.affiliation: School of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Labarca
authors.affiliation: Universidad del Desarrollo, Santiago, Chile.
authors.forename: Sofia
authors.initials: S
authors.lastname: Canals
authors.affiliation: Universidad del Desarrollo, Santiago, Chile.
authors.forename: Iván
authors.initials: I
authors.lastname: Caviedes
authors.affiliation: Harvard Medical School, Boston, MA, USA.
authors.forename: Erik
authors.initials: E
authors.lastname: Folch
authors.affiliation: Harvard Medical School, Boston, MA, USA.
authors.forename: Adnan
authors.initials: A
authors.lastname: Majid
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult