title: Hyperthermia Is Now Included in the NCCN Clinical Practice Guidelines for Breast Cancer Recurrences: An Analysis of Existing Data.
abstract: BACKGROUND
  Hyperthermia has been included in the 2013 National Comprehensive Cancer Network (NCCN) guidelines as an option for the treatment of breast recurrences. The purpose of this article is to demonstrate the important role of hyperthermia as a therapeutic modality by presenting clinical trials on this subject carried out in the last decades.
  
  
  METHODS
  All relevant trials published since 1987 were retrieved from Medline and reviewed.
  
  
  RESULTS
  Results show that the addition of hyperthermia to radiotherapy and/or chemotherapy for the treatment of breast cancer enhances treatment response and can increase local control.
  
  
  CONCLUSIONS
  Further studies are required to evaluate potential benefits of hyperthermia in the treatment of other kinds of superficial tumors.
authors.affiliation: 2nd Dept. of Radiology, Attikon University Hospital, Radiotherapy Unit, Athens, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Kouloulias
authors.affiliation: 1st Dept. of Radiology, Attikon University Hospital, Radiotherapy Unit, Athens, Greece.
authors.forename: Sotiria
authors.initials: S
authors.lastname: Triantopoulou
authors.affiliation: National Technical University of Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Uzunoglou
authors.affiliation: Radiotherapy Dept., AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Pistevou-Gompaki
authors.affiliation: Euromedica Hospital, Thessaloniki, Greece.
authors.forename: Alfred
authors.initials: A
authors.lastname: Barich
authors.affiliation: 1st Dept. of Radiology, Attikon University Hospital, Radiotherapy Unit, Athens, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Zygogianni
authors.affiliation: Radiotherapy Dept., Larisa University Hospital, Larisa, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Kyrgias
authors.affiliation: Radiotherapy Dept., University Hospital, Rion, Patras, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kardamakis
authors.affiliation: Oncology Dept., Hippokrateion Hospital, Athens, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Pectasidis
authors.affiliation: 1st Dept. of Radiology, Attikon University Hospital, Radiotherapy Unit, Athens, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Kouvaris
keywords: Breast cancer recurrences; Clinical trials; Hyperthermia; Radiotherapy