title: Ionic liquid-molecularly imprinted polymers for pipette tip solid-phase extraction of (Z)-3-(chloromethylene)-6-flourothiochroman-4-one in urine.
abstract: A new type of ionic liquid-molecularly imprinted polymers (IL-MIPs) synthesized by precipitation polymerization using 1-allyl-3-methylimidazolium bromide and acrylamide as co-functional monomers and (Z)-6-fluoro-3-(hydroxymethylene)-thiochroman-4-one (FHO) as dummy template was successfully applied as a selective adsorbent of pipette tip solid-phase extraction (PT-SPE) for rapid extraction and determination of (Z)-3-(chloromethylene)-6-flourothiochroman-4-one (CFO) in urine. The factors that affected the extraction efficiency including amounts of adsorbent, types of washing solvent, and types and volumes of elution solvent were optimized. Under the optimum conditions of ionic liquid-molecularly imprinted polymers-pipette tip solid-phase extraction (IL-MIPs-PT-SPE) coupled with HPLC-UV, good linearity for CFO was achieved in a range of 0.1-10.0μgmL(-1) (r=0.9999) and the recoveries at three spiked levels were ranged from 94.8% to 103.4% with the relative standard deviations (RSDs) less than 5.7% (n=3).
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China.
authors.forename: Shiru
authors.initials: S
authors.lastname: Liang
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China. Electronic address: yanhy@hbu.edu.cn.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Yan
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China.
authors.forename: Zhengyue
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Liu
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000652:urine*; D002839:Chromans / Q000737:chemistry / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D052578:Ionic Liquids; D054802:Molecular Imprinting; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis; D052616:Solid Phase Extraction / Q000379:methods; D013237:Stereoisomerism
chemical_list: C544334:1-allyl-3-methylimidazolium; C000602464:3-(chloromethylene)-6-flourothiochroman-4-one; D000498:Allyl Compounds; D000970:Antineoplastic Agents; D002839:Chromans; D007093:Imidazoles; D052578:Ionic Liquids; D011108:Polymers; D020106:Acrylamide
keywords: (Z)-3-(chloromethylene)-6-flourothiochroman-4-one; Ionic liquid-molecularly imprinted polymers; Pipette tip solid-phase extraction; Urine