title: Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway.
abstract: Quetiapine (QUE) and repetitive transcranial magnetic stimulation (rTMS) have been considered to be possible monotherapies for depression or adjunctive therapies for the treatment of the resistant depression, but the underlying mechanisms remain unclear. The present study aimed to assess the effects of combined QUE and rTMS treatment on depressive-like behaviors, hippocampal proliferation, and the in vivo and in vitro expressions of phosphorylated extracellular signal-regulated protein kinase (pERK1/2) and brain-derived neurotrophic factor (BDNF) in male Sprague-Dawley rats. The administration of QUE and rTMS was determined not only to reverse the depressive-like behaviors of rats exposed to chronic unpredictable stress (CUS) but also to restore the protein expressions of pERK1/2 and BDNF and cell proliferation in the hippocampus. Additionally, QUE and rTMS promoted the proliferation and increased the expression of pERK1/2 and BDNF in hippocampal-derived neural stem cells (NSCs), and these effects were abolished by U0126. Taken together, these results suggest that the antidepressive-like effects of QUE and rTMS might be related to the activation of the BDNF/ERK signaling pathway and the up-regulation of cell proliferation in the hippocampus.
authors.affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Yi-huan
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Rui-guo
authors.initials: RG
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Xue
authors.affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Hua-ning
authors.initials: HN
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Yun-chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Mental Health Center, 324 Hospital of PLA, Chongqing 400041, China.
authors.forename: Guang-tao
authors.initials: GT
authors.lastname: Hu
authors.affiliation: Air Force General Hospital of PLA, Beijing, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address: pengzhengwu1446@163.com.
authors.forename: Zheng-wu
authors.initials: ZW
authors.lastname: Peng
authors.affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address: tanqingr@fmmu.edu.cn.
authors.forename: Qing-rong
authors.initials: QR
authors.lastname: Tan
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D002070:Butadienes / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003863:Depression / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000166:cytology*; D020935:MAP Kinase Signaling System / Q000187:drug effects*; D008297:Male; D058953:Neural Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D009570:Nitriles / Q000494:pharmacology; D000069348:Quetiapine Fumarate / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D050781:Transcranial Magnetic Stimulation
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D002070:Butadienes; D009570:Nitriles; C113580:U 0126; D000069348:Quetiapine Fumarate
keywords: BDNF/ERK; CUS; NSCs; Quetiapine; rTMS