title: Cd(2+) Triggered the FRET "ON": A New Molecular Switch for the Ratiometric Detection of Cd(2+) with Live-Cell Imaging and Bound X-ray Structure.
abstract: On the basis of the Förster resonance energy transfer mechanism between rhodamine and quinoline-benzothiazole conjugated dyad, a new colorimetric as well as fluorescence ratiometric probe was synthesized for the selective detection of Cd(2+). The complex formation of the probe with Cd(2+) was confirmed through Cd(2+)-bound single-crystal structure. Capability of the probe as imaging agent to detect the cellular uptake of Cd(2+) was demonstrated here using living RAW cells.
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Aich
authors.forename: Shyamaprosad
authors.initials: S
authors.lastname: Goswami
authors.forename: Sangita
authors.initials: S
authors.lastname: Das
authors.forename: Chitrangada Das
authors.initials: CD
authors.lastname: Mukhopadhyay
authors.affiliation: §X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.
authors.forename: Ching Kheng
authors.initials: CK
authors.lastname: Quah
authors.affiliation: §X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.|∥Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Hoong-Kun
authors.initials: HK
authors.lastname: Fun
mesh_terms: D000818:Animals; D052160:Benzothiazoles / Q000737:chemistry; D002104:Cadmium / Q000032:analysis* / Q000737:chemistry*; D002470:Cell Survival; D018360:Crystallography, X-Ray; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods*; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D011804:Quinolines / Q000737:chemistry; D000067996:RAW 264.7 Cells; D012235:Rhodamines / Q000737:chemistry
chemical_list: D052160:Benzothiazoles; D011804:Quinolines; D012235:Rhodamines; D002104:Cadmium; C037219:quinoline; C005465:benzothiazole