title: Interethnic variability of CYP4F2 (V433M) in admixed population of Roma and Hungarians.
abstract: OBJECTIVE
  Pharmacogenetic based dosing recommendations are provided in FDA-approved warfarin label for Caucasians. Evidence of notable difference in dosing algorithms of under-represented populations forced us to explore the genetic variability of CYP4F2 gene in Roma and Hungarian populations.
  
  
  METHODS
  484 Roma, 493 Hungarian untreated subjects were genotyped for the CYP4F2*3 (rs2108622) variant by PCR-RFLP assay.
  
  
  CONCLUSIONS
  We firstly report, that frequencies of the CYP4F2 rs2108622 GG, GA, AA genotypes and A allele in the Roma population were 46.5%, 42.6%, 10.9% and 32.2%; in Hungarians 50.1%, 42.2%, 7.7% and 22.8%, respectively. Bearing of two minor alleles of CYP4F2 missense variant (AA genotype) modestly explains inter-ethnic differences of studied populations (p<0.08). CYP4F2*3 (V433M) risk allele frequency of Roma (0.32) was in higher range, and of Hungarians (0.23) in lower range, as compared with other world populations.
  
  
  CONCLUSIONS
  Roma have an elevated chance for higher mean warfarin dose, besides a decreased risk of major bleeding events in long-term warfarin use.
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary; Human Genetic and Pharmacogenetic Research Group, Janos Szentagothai Research Centre, Ifjusag 20, H-7624 Pecs, Hungary. Electronic address: csilla.sipeky@aok.pte.hu.
authors.forename: Csilla
authors.initials: C
authors.lastname: Sipeky
authors.affiliation: B.A.Z County Hospital and University Teaching Hospital, Szentpeteri Gate 72-76, H-3526 Miskolc, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Weber
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary.
authors.forename: Bela I
authors.initials: BI
authors.lastname: Melegh
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary.
authors.forename: Petra
authors.initials: P
authors.lastname: Matyas
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Janicsek
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary; Human Genetic and Pharmacogenetic Research Group, Janos Szentagothai Research Centre, Ifjusag 20, H-7624 Pecs, Hungary.
authors.forename: Renata
authors.initials: R
authors.lastname: Szalai
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary.
authors.forename: Istvan
authors.initials: I
authors.lastname: Szabo
authors.affiliation: University of Pecs, Institute of Family Medicine, Akac str. 1, H-7632 Pecs, Hungary.
authors.forename: Reka
authors.initials: R
authors.lastname: Varnai
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary.
authors.forename: Greta
authors.initials: G
authors.lastname: Tarlos
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary.
authors.forename: Alma
authors.initials: A
authors.lastname: Ganczer
authors.affiliation: University of Pecs, Clinical Centre, Department of Medical Genetics, Szigeti 12, H-7624 Pecs, Hungary; Human Genetic and Pharmacogenetic Research Group, Janos Szentagothai Research Centre, Ifjusag 20, H-7624 Pecs, Hungary.
authors.forename: Bela
authors.initials: B
authors.lastname: Melegh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072470:Cytochrome P450 Family 4; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D006178:Romani People; D055815:Young Adult
chemical_list: D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C117480:CYP4F2 protein, human
keywords: CYP4F2*3 (rs2108622, V433M); Hungarian; Population pharmacogenetics; Roma