title: [Relationship between serum level of uric acid and benign paroxysmal positional vertigo].
abstract: OBJECTIVE
  To confirm the possible relationships between serum level of uric acid (UA) and benign paroxysmal positional vertigo (BPPV).
  
  
  METHODS
  A total of 87 patients with BPPV and 36 age- and gender-matched control subjects were recruited from our hospital between July 1, 2013 and July 1, 2014. All patients underwent a complete audio-vestibular test battery, such as Dix-Hallpike maneuver for posterior semicircular canal and supine roll test for horizontal semicircular canal. All risk factors such as the histories of heart and cerebral vascular diseases, and routine hematological and biochemical analyses were analyzed between two groups.
  
  
  RESULTS
  No significant inter-group differences existed in age, gender, histories of hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease, smoking or drinking (P > 0.05). No significant differences existed between systolic blood pressure, diastolic blood pressure, ejection fraction, whole blood count, lipid profile, homocysteine, prealbumin and blood urea nitrogen in patients with BPPV compared with controls (P >0. 05). However, the values of UA (267 ± 86 vs 325 ± 75) µmol/L, hemoglobin ale (5.6 ± 1. 4 vs 6.5 ± 1. 0)%, albumin (36 ± 4 vs 40 ± 4) g/L and creatinine (72 ± 20 vs 81 ± 22) µmol/L were much lower in patients with BPPV versus controls (P < 0. 05). According to multiple Logistic regression model, the lower levels of hemoglobin ale and albumin were independently associated with BPPV (P <0. 05) with the odds ratio of 1. 473 (95% CI 1. 066 - 2. 037) and 1. 162 (95% CI 1. 025 - 1. 318), respectively. However, the level of UA was not independently correlated with the occurrence of BPPV [OR = 1. 005 (95% CI 1. 000 - 1. 011), P =0. 063].
  
  
  CONCLUSIONS
  The lower levels of hemoglobin alc and albumin are independently associated with BPPV. Although the value of UA is lower in patients with BPPV versus controls, it is not an independent risk factor for BPPV. Due to limited patient data, further studies are needed to clarify the association in a larger sample size of different ethnic groups or longer follow ups.
authors.forename: Junliang
authors.initials: J
authors.lastname: Yuan
authors.forename: Yili
authors.initials: Y
authors.lastname: Chen
authors.forename: Yudan
authors.initials: Y
authors.lastname: Chen
authors.forename: Shiqin
authors.initials: S
authors.lastname: Niu
authors.forename: Shujuan
authors.initials: S
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Dong
authors.forename: Wenli
authors.initials: W
authors.lastname: Hu
mesh_terms: D065635:Benign Paroxysmal Positional Vertigo; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D003324:Coronary Artery Disease; D003404:Creatinine; D005260:Female; D006801:Humans; D008297:Male; D010808:Physical Examination; D012307:Risk Factors; D012665:Semicircular Canals; D014527:Uric Acid
chemical_list: D014527:Uric Acid; D003404:Creatinine