title: Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library.
abstract: Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.
authors.affiliation: Centre for Systems Chemistry, Stratingh Insitute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Piotr
authors.initials: P
authors.lastname: Nowak
authors.affiliation: Centre for Systems Chemistry, Stratingh Insitute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Colomb-Delsuc
authors.affiliation: Centre for Systems Chemistry, Stratingh Insitute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Sijbren
authors.initials: S
authors.lastname: Otto
authors.affiliation: Centre for Systems Chemistry, Stratingh Insitute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Li