title: Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer.
abstract: The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) regulates cell motility via the transcriptional or post-transcriptional control of motility-related genes. Whether MALAT1 plays a critical role in cancer progression in breast cancer remains unclear. In this study, we found that MALAT1 was downregulated in breast tumor cell lines and cancer tissue, and showed that knockdown of MALAT1 in breast cancer cell lines induced an epithelial-to-mesenchymal transition (EMT) program via phosphatidylinositide-3 kinase-AKT pathways. Furthermore, lower expression of MALAT1 in breast cancer patients was associated with shorter relapse-free survival. Thus, our results indicate for the first time that MALAT1 is a novel regulator of EMT in breast cancer and may be a potential therapeutic target for breast cancer metastasis.
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Shouping
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Shiyao
authors.initials: S
authors.lastname: Sui
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Nanxia
authors.initials: N
authors.lastname: Bai
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Tumor Biobank, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Guangwen
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: You
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhan
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital 150 Haping Road, Harbin, China ; Heilongjiang Academy of Medical Sciences 157 Baojian Road, Harbin 150086, China ; Sino-Russian Medical Research Center, Heilongjiang Academy of Medical Sciences 157 Baojian Road, Harbin, China ; Northern (China) Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences 157 Baojian Road, Harbin, China.
authors.forename: Da
authors.initials: D
authors.lastname: Pang
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D018572:Disease-Free Survival; D015536:Down-Regulation; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D061986:MCF-7 Cells; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D011379:Prognosis; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D034622:RNA Interference; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D012307:Risk Factors; D015398:Signal Transduction; D013997:Time Factors; D014162:Transfection
chemical_list: C557041:MALAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding; D058539:Phosphatidylinositol 3-Kinase; D051057:Proto-Oncogene Proteins c-akt
keywords: EMT; Long noncoding RNA; MALAT1; breast cancer; metastasis