title: Role of Hydrogen-Bonding Acceptors in Organo-Enamine Catalysis.
abstract: A hydrogen bond acceptor plays an important role in the catalytic cycle of organo-enamine catalysis. It can effectively influence the rate of reaction through hydrogen bonding interaction with enammonium (N-protonated enamine intermediate). Our findings are supported by both kinetic experiments and quantum chemical calculations.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky 40292 (USA).
authors.forename: Junbin
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky 40292 (USA).
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky 40292 (USA).
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Flach
authors.affiliation: Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK). robert.paton@chem.ox.ac.uk.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Paton
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky 40292 (USA). gb.hammond@louisville.edu.
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620 (P. R. China). bo.xu@dhu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
keywords: enamine; hydrogen bonding acceptor; kinetics; organocatalysis