title: Attention Deficit Hyperactivity Disorder and oxidative stress: A short term follow up study.
abstract: In this study, we aimed to investigate total antioxidative status (TAS) and total oxidative status (TOS) of plasma and antioxidant enzymes such as paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARES) and thiols in plasma of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD). In the second step. this study aimed to reveal the possible effects of ADHD treatment on these parameters. Fifty-six patients with ADHD and 52 healthy controls were involved in this study. Venous blood samples were collected and oxidative and antioxidative parameter's were studied. In the second phase of the study, blood samples were taken from patients using medication. Pre-treatment oxidative stress index (OSI) values and the plasma TOS levels of the patients with ADHD were statistically higher than those of the control group. The plasma thiol levels of the patients with ADHD were significantly lower than the control group. The post-treatment plasma antioxidative parameter's levels were significantly higher than the pre-treatment levels. The post-treatment oxidative stress index value was significantly lower than the pre-treatment value. Therefore, oxidative metabolism was found to be impaired in children and adolescents with ADHD. It was also determined that methylphenidate repairs the oxidative balance by increasing antioxidant defence mechanisms.
authors.affiliation: Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey. Electronic address: dresraguney@gmail.com.
authors.forename: Esra
authors.initials: E
authors.lastname: Guney
authors.affiliation: Kayseri Training and Research Hospital, Department of Child and Adolescent Psychiatry, Kayseri, Turkey.
authors.forename: Fatih Hilmi
authors.initials: FH
authors.lastname: Cetin
authors.affiliation: Yildirim Beyazit University Medical Faculty, Atatürk Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alisik
authors.affiliation: Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Tunca
authors.affiliation: Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Tas Torun
authors.affiliation: Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey.
authors.forename: Elvan
authors.initials: E
authors.lastname: Iseri
authors.affiliation: Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey.
authors.forename: Yasemen
authors.initials: Y
authors.lastname: Isik Taner
authors.affiliation: Gazi University Medical Faculty, Department of Medical Biochemistry, Ankara, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Cayci
authors.affiliation: Yildirim Beyazit University Medical Faculty, Atatürk Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D000697:Central Nervous System Stimulants / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology / Q000627:therapeutic use; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase
keywords: Attention Deficit Hyperactivity Disorder; Medication; Oxidative stress; Total antioxidative status; Total oxidative status