title: Outcomes of Liver Resection in the Elderly: Is it safe?
abstract: OBJECTIVE
  There has been an increase in the incidence of neoplasms of the liver in recent years, although there is still a fear of performing aggressive surgical procedures in elderly patients, especially regarding hepatic surgery. The objective of this study was to analyse the influence of age on the morbidity and mortality of patients undergoing hepatic resection.
  
  
  METHODS
  This was a study of 414 patients who underwent 447 hepatic resections between November 1993 and December 2010. The patients were divided into two groups according to whether they were ≤ 65 or > 65 years of age.
  
  
  RESULTS
  The elderly group included 113 resections, while the young group was composed of 334 procedures. The elderly group had more malignant lesions and more comorbidities. With regard to the transoperative and post-operative data, the two groups displayed similar results. According to the multivariate analysis, cirrhosis and the use of transoperative pedicular clamping were independent predictors of morbidity. Cirrhosis was also an independent predictor of mortality.
  
  
  CONCLUSIONS
  The results indicate that age is not a predisposing factor for the worsening of results of hepatic resection in selected patients, especially with regard to cirrhosis. Moreover, surgeons must avoid the use of transoperative pedicular clamping.
authors.forename: Antônio Nocchi
authors.initials: AN
authors.lastname: Kalil
authors.forename: Gustavo Andreazza
authors.initials: GA
authors.lastname: Laporte
authors.forename: André
authors.initials: A
authors.lastname: Rodrigues
authors.forename: Renata Mello
authors.initials: RM
authors.lastname: Felipe
authors.forename: Sérgio López
authors.initials: SL
authors.lastname: Torrez
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D016009:Chi-Square Distribution; D015897:Comorbidity; D003250:Constriction; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000401:mortality; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult