title: White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline.
abstract: OBJECTIVE
  In patients with subjective cognitive decline, we assessed whether small vessel disease was associated with clinical progression and cognitive decline.
  
  
  METHODS
  We included 334 patients with subjective cognitive decline. Follow-up was 3±2 years.
  
  
  RESULTS
  Fifty-three (16%) patients progressed clinically to mild cognitive impairment or dementia. White matter hyperintensities were associated with clinical progression and with annual decline on memory, attention, executive functioning, and global cognition. Microbleeds and lacunes were not associated with clinical progression or cognitive decline.
  
  
  CONCLUSIONS
  In patients with subjective cognitive decline, patients with white matter hyperintensities are at increased risk of clinical progression and cognitive decline.
authors.affiliation: From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. M.Benedictus@vumc.nl.
authors.forename: Marije R
authors.initials: MR
authors.lastname: Benedictus
authors.affiliation: From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Argonde C
authors.initials: AC
authors.lastname: van Harten
authors.affiliation: From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Annebet E
authors.initials: AE
authors.lastname: Leeuwis
authors.affiliation: From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Teddy
authors.initials: T
authors.lastname: Koene
authors.affiliation: From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.affiliation: From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Niels D
authors.initials: ND
authors.lastname: Prins
authors.affiliation: From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
mesh_terms: D003072:Cognition Disorders / Q000473:pathology* / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000473:pathology / Q000503:physiopathology; D003704:Dementia / Q000473:pathology* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D066127:White Matter / Q000473:pathology*
keywords: cognitive decline; small vessel disease; subjective complaints; vascular cognitive impairment; white matter lesions