title: Clear cell papillary renal cell carcinoma: a clinicopathologic analysis of 6 cases.
abstract: Clear cell papillary renal cell carcinoma (CCPRCC) is a newly described variant of renal cell carcinoma (RCC) which is composed mainly of cells with clear cytoplasm arranged in cystic and papillary patterns. We report the clinicopathologic features, prognosis and differential diagnosis of 6 Clear Cell Papillary Renal Cell Carcinomas. The clinical information and follow-up data were analyzed. The patients were six males with median age of 52.5 years. Case 1 revealed dense calcification and ossification. Cases 2 and 3 contain a variably prominent smooth muscle stromal component. CA-IX, CK7, PAX-8 and VIM were positive in all cases. TFE3 and AMACR were not expressed in any tumor. CD10 was negative in 5 of 6 cases .The patients were followed for 13~55 months with no local tumor recurrences and tumor metastasis. The CCPRCC was associated with a more favorable outcome. These were low-grade and low-stage renal tumors. No lymph node or distant metastasis of the six tumors.
authors.affiliation: Department of Pathology, The Eighth People's Hospital of Qingdao Qingdao 266100, China.
authors.forename: Wen-Xiu
authors.initials: WX
authors.lastname: Yan
authors.affiliation: Department of Pathology, The Eighth People's Hospital of Qingdao Qingdao 266100, China.
authors.forename: Wen-Rong
authors.initials: WR
authors.lastname: Cao
authors.affiliation: Department of Pathology, The Eighth People's Hospital of Qingdao Qingdao 266100, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Pathology, 401 Hospital of PLA Qingdao 266100, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The Eighth People's Hospital of Qingdao Qingdao 266100, China.
authors.forename: Xue-Li
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Eighth People's Hospital of Qingdao Qingdao 266100, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: Department of Pathology, The Eighth People's Hospital of Qingdao Qingdao 266100, China.
authors.forename: Shou-Qin
authors.initials: SQ
authors.lastname: Dang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009392:Nephrectomy; D011237:Predictive Value of Tests; D017154:Stromal Cells / Q000737:chemistry / Q000473:pathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Kidney; clear cell papillary renal cell Carcinoma; leiomyomatous stroma; neoplasia; osseous metaplasia