title: Sulfamethoxazole susceptibility of Mycobacterium tuberculosis isolates from HIV-infected Ugandan adults with tuberculosis taking trimethoprim-sulfamethoxazole prophylaxis.
abstract: Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patients in sub-Saharan Africa. Thirty-eight of 40 Mycobacterium tuberculosis isolates (95%) from pretreatment sputum samples from Ugandan adults with pulmonary TB, including HIV-infected patients taking trimethoprim-sulfamethoxazole prophylaxis, were susceptible with MICs of ≤38.4 μg/ml.
authors.affiliation: Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda Joint Clinical Research Centre, Kampala, Uganda.
authors.forename: Sam
authors.initials: S
authors.lastname: Ogwang
authors.affiliation: Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: Caryn E
authors.initials: CE
authors.lastname: Good
authors.affiliation: Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.
authors.forename: Brenda
authors.initials: B
authors.lastname: Okware
authors.affiliation: Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.
authors.forename: Mary
authors.initials: M
authors.lastname: Nsereko
authors.affiliation: Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
authors.affiliation: Tuberculosis Research Unit, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: W Henry
authors.initials: WH
authors.lastname: Boom
authors.affiliation: Tuberculosis Research Unit, Case Western Reserve University, Cleveland, Ohio, USA MetroHealth Medical Center, Cleveland, Ohio, USA cmb148@case.edu.
authors.forename: Charles M
authors.initials: CM
authors.lastname: Bark
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000472:pathogenicity; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination