title: Comparing Tapering Strategy to Standard Dosing Regimen of Tumor Necrosis Factor Inhibitors in Patients with Spondyloarthritis in Low Disease Activity.
abstract: OBJECTIVE
  To compare clinical outcomes, incidence of flares, and administered drug reduction between patients with spondyloarthritis (SpA) under TNF inhibitor (TNFi) tapering strategy with patients receiving a standard regimen.
  
  
  METHODS
  In this retrospective study, 74 patients with SpA from Spain on tapering strategy (tapering group; TG) were compared with 43 patients from the Netherlands receiving a standard regimen (control group; CG). The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was measured at visit 0 (prior to starting the TNFi), visit 1 (prior to starting tapering strategy in TG and at least 6 months with BASDAI < 4 after starting the TNFi in the TG and CG), visit 2 (6 mos after visit 1), visit 3 (1 year after visit 1), and visit 4 (the last visit available after visit 1).
  
  
  RESULTS
  An overall reduction of the administered drug was seen at visit 4 in the TG [dose reduction of 22% for infliximab (IFX) and an interval elongation of 28.7% for IFX, 45.2% for adalimumab, and 51.5% for etanercept] without significant differences in the BASDAI between the groups at visit 4 (2.15 ± 1.55 in TG vs 2.11 ± 1.31 in CG, p = 0.883). The number of patients with flares was similar in both groups [22/74 (30%) in the TG vs 8/43 (19%) in the CG, p = 0.184].
  
  
  CONCLUSIONS
  The tapering strategy in SpA results in an important reduction of the drug administered, and the disease control remains similar to that of the patients with SpA receiving the standard regimen.
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital. chamiplasencia@hotmail.com.
authors.forename: Chamaida
authors.initials: C
authors.lastname: Plasencia
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Eva L
authors.initials: EL
authors.lastname: Kneepkens
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Gertjan
authors.initials: G
authors.lastname: Wolbink
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Charlotte L M
authors.initials: CL
authors.lastname: Krieckaert
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Samina
authors.initials: S
authors.lastname: Turk
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Victoria
authors.initials: V
authors.lastname: Navarro-Compán
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Merel
authors.initials: M
authors.lastname: L'Ami
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Mike T
authors.initials: MT
authors.lastname: Nurmohamed
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Irene
authors.initials: I
authors.lastname: van der Horst-Bruinsma
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Teresa
authors.initials: T
authors.lastname: Jurado
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Cristina
authors.initials: C
authors.lastname: Diego
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Gema
authors.initials: G
authors.lastname: Bonilla
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Villalba
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Diana
authors.initials: D
authors.lastname: Peiteado
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Laura
authors.initials: L
authors.lastname: Nuño
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Desiree
authors.initials: D
authors.lastname: van der Kleij
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Theo
authors.initials: T
authors.lastname: Rispens
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Emilio
authors.initials: E
authors.lastname: Martín-Mola
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Balsa
authors.affiliation: From the La Paz University Hospital, and the Rheumatology Department, La Paz University Hospital-Idipaz, Madrid, Spain; Sanquin Diagnostic Services; Department of Rheumatology, VU University Medical Centre; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; Jan van Breemen Research Institute|Reade, Amsterdam, the Netherlands.C. Plasencia, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; E.L. Kneepkens, MD; G. Wolbink, PhD; C.L. Krieckaert, MD; S. Turk, MD, Jan van Breemen Research Institute|Reade; V. Navarro-Compán, MD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; M. L'Ami, MSc, Jan van Breemen Research Institute|Reade; M.T. Nurmohamed, PhD; I. van der Horst-Bruinsma, PhD, Jan van Breemen Research Institute|Reade and Sanquin Diagnostic Services; T. Jurado, MSC; C. Diego, BSC, La Paz University Hospital; G. Bonilla, MD; A. Villalba, MD; D. Peiteado, MD; L. Nuño, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. van der Kleij, PhD, Sanquin Diagnostic Services; T. Rispens, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam; E. Martín-Mola, PhD; A. Balsa, PhD, Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Rheumatology Department, La Paz University Hospital-Idipaz; D. Pascual-Salcedo, PhD, La Paz University Hospital.
authors.forename: Dora
authors.initials: D
authors.lastname: Pascual-Salcedo
mesh_terms: D000068879:Adalimumab / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D000068800:Etanercept / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000069285:Infliximab / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013030:Spain; D025241:Spondylarthritis / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D018501:Antirheumatic Agents; D000069285:Infliximab; D000068879:Adalimumab; D000068800:Etanercept
keywords: CLINICAL OUTCOMES; SPONDYLOARTHRITIS; TAPERING; TNF INHIBITORS; TREATMENT