title: Why and How Does Pressure Unfold Proteins?
abstract: This year, 2014, marks the 100th anniversary of the first publication reporting the denaturation of proteins by high hydrostatic pressure (Bridgman 1914). Since that time a large and recently increasing number of studies of pressure effects on protein stability have been published, yet the mechanism for the action of pressure on proteins remains subject to considerable debate. This review will present an overview from this author's perspective of where this debate stands today.
authors.affiliation: Department of Biology, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA, royerc@rpi.edu.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Royer
mesh_terms: D006874:Hydrostatic Pressure; D058767:Protein Unfolding; D011506:Proteins / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D011506:Proteins; D012997:Solvents