title: Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus.
abstract: A series of novel hybrids possessing chalcone and thiazole moieties were synthesized and evaluated for their antibacterial activities. In general this class of hybrids exhibited potency against Staphylococcus aureus, and in particular, compound 27 exhibited potent inhibitory activity with respect to other synthesized hybrids. Furthermore, the hemolytic and toxicity data demonstrated that the compound 27 was nonhemolytic and nontoxic to mammalian cells. The in vivo studies utilizing a S. aureus septicemia model demonstrated that compound 27 was as potent as vancomycin. The results of antibacterial activities underscore the potential of this scaffold that can be utilized for developing a new class of novel antibiotics.
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: K Bhaskara
authors.initials: KB
authors.lastname: Rao
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: Pragati
authors.initials: P
authors.lastname: Kushwaha
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: Ram K
authors.initials: RK
authors.lastname: Modukuri
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: Pratiksha
authors.initials: P
authors.lastname: Singh
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: Isha
authors.initials: I
authors.lastname: Soni
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Shukla
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: Sidharth
authors.initials: S
authors.lastname: Chopra
authors.affiliation: Medicinal & Process Chemistry Division and Division of Microbiology, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram extension, Sitapur Road, Lucknow-226031, Uttar Pradesh, India.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Pasupuleti
keywords: Chalcone−thiazole hybrids; MIC; Staphylococcus aureus; antibacterial activities