title: Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials.
abstract: BACKGROUND
  The independent or interactive effects of vitamin D and calcium on adiposity remain inconclusive.
  
  
  OBJECTIVE
  The objective of this systematic review and meta-analysis was to assess whether vitamin D and calcium supplements cause changes in adiposity.
  
  
  METHODS
  MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials databases were searched for literature published from 1966 to March 2014.
  
  
  METHODS
  A systematic search was conducted for randomized clinical trials with ≥ 50 participants aged ≥ 18 years at baseline who had received at least 12 weeks of treatment. Among the inclusion criteria were supplementation with vitamin D with or without calcium and measurement of adiposity (weight, body mass index [BMI], and/or fat mass).
  
  
  METHODS
  The primary endpoints assessed were changes in weight, BMI, or fat mass.
  
  
  RESULTS
  Of 953 trials identified, 26 randomized clinical trials (n = 12, vitamin D alone; n = 10, vitamin D plus calcium versus calcium control; n = 4, vitamin D plus calcium versus placebo) with a total of 42,430 participants (median duration, 12 months) met the inclusion criteria. When compared with placebo, vitamin D supplementation had no significant effect on BMI (weighted mean difference [WMD], -0.06 kg/m(2); 95% confidence interval [95%CI], -0.14 to 0.03), weight (WMD, -0.05 kg; 95%CI, -0.32 to 0.23), or fat mass (WMD, -0.43 kg; 95%CI, -1.69 to 0.84). Likewise, no significant reduction in BMI (WMD, 0.02 kg/m(2); 95%CI, -0.11 to 0.14), weight (WMD, 0.12 kg; 95%CI, -0.24 to 0.49), or fat mass (WMD, 0.12 kg; 95%CI, -0.22 to 0.45) was observed in participants who received vitamin D plus calcium compared with those who received calcium control.
  
  
  CONCLUSIONS
  Supplementation with vitamin D showed no effect on adiposity measures in adults.
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. pchandler@partners.org.
authors.forename: Paulette D
authors.initials: PD
authors.lastname: Chandler
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Howard D
authors.initials: HD
authors.lastname: Sesso
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Manickavasagar V
authors.initials: MV
authors.lastname: Moorthy
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Obiageli
authors.initials: O
authors.lastname: Obi
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Lewis
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Prince
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Jacqueline S
authors.initials: JS
authors.lastname: Danik
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: JoAnn E
authors.initials: JE
authors.lastname: Manson
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Meryl S
authors.initials: MS
authors.lastname: LeBoff
authors.affiliation: P.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Song
mesh_terms: D050154:Adiposity / Q000187:drug effects*; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000008:administration & dosage*; D019587:Dietary Supplements; D006801:Humans; D009765:Obesity / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D014807:Vitamin D / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins; D014807:Vitamin D; D002118:Calcium
keywords: adiposity; obesity; supplementation; vitamin D