title: Obesity and inflammatory biomarkers in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS.
  
  
  METHODS
  Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-müllerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured.
  
  
  RESULTS
  Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL.
  
  
  CONCLUSIONS
  The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039.
authors.affiliation: Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Szu-Hung
authors.initials: SH
authors.lastname: Shen
authors.affiliation: Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Szu-Yu
authors.initials: SY
authors.lastname: Shen
authors.affiliation: Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Tsan-Hon
authors.initials: TH
authors.lastname: Liou
authors.affiliation: Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: hsumingi@yahoo.com.tw.
authors.forename: Ming-I
authors.initials: MI
authors.lastname: Hsu
authors.affiliation: Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.
authors.forename: Yuan-chin Ivan
authors.initials: YC
authors.lastname: Chang
authors.affiliation: Institute for Labor Research, National Chengchi University, Taipei, Taiwan.
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Chun-Sen
authors.initials: CS
authors.lastname: Hsu
authors.affiliation: Department of Obstetrics and Gynaecology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Chii-Ruey
authors.initials: CR
authors.lastname: Tzeng
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D012189:Retrospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D054392:Adipokines; D015415:Biomarkers; D007328:Insulin; D015850:Interleukin-6; D008077:Lipoproteins, LDL; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D054304:Anti-Mullerian Hormone; D002097:C-Reactive Protein; D002784:Cholesterol
keywords: Adiponectin; Inflammation; Leptin; Obesity; PCOS; Resistin