title: MAPK/JNK signalling: a potential autophagy regulation pathway.
abstract: Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization. This pathway maintains nutrients levels for vital cellular functions during periods of starvation and it provides cells with survival advantages under various stress situations. However, the mechanisms responsible for the induction and regulation of autophagy are poorly understood. The c-Jun NH2-terminal kinase (JNK) signal transduction pathway functions to induce defence mechanisms that protect organisms against acute oxidative and xenobiotic insults. This pathway has also been repeatedly linked to the molecular events involved in autophagy regulation. The present review will focus on recent advances in understanding of the relationship between mitogen-activated protein kinase (MAPK)/JNK signalling and autophagic cell death.
authors.affiliation: Medical Biotechnology Laboratory, Zhejiang University, Hangzhou 310058, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhou
authors.affiliation: Children's Hospital Affiliated to the Medical College of Zhejiang University, 268 Kaixuan Road, Jianggan District, Hangzhou 310029, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Cancer Center, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Shangcheng District, Hangzhou 310003, China.
authors.forename: Wei-Qin
authors.initials: WQ
authors.lastname: Jiang
authors.affiliation: Medical Biotechnology Laboratory, Zhejiang University, Hangzhou 310058, China 239zlf@zju.edu.cn.
authors.forename: Lin-Fu
authors.initials: LF
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D000071186:Beclin-1 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C491997:BECN1 protein, human; D000071186:Beclin-1; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases
keywords: B-cell lymphoma 2 (Bcl-2); Beclin1; autophagic cell death; autophagy; mitogen-activated protein kinase (MAPK)/c-Jun NH2-terminal kinase (JNK)