title: The impact of Ets-1 oncoprotein and human endoglin (CD105) on the recurrence of non-melanoma skin cancers.
abstract: BACKGROUND
  The aim of this study was to investigate if the expression of CD105 and Ets-1 was predictive of aggressive biologic behavior of non-melanoma skin cancers (NMSC) and to evaluate indicators of local recurrence.
  
  
  METHODS
  A total of 144 patients with NMSC were included in the current study. Surgical specimens were independently examined for diagnosis confirmation and immunohistochemical expression of Ets-1 and CD105 by two dermatopathologists.
  
  
  RESULTS
  The most common tumor type was basal cell carcinoma (n = 76), followed by squamous cell carcinomas (SCC) (n = 65). The most common anatomic location was the head and neck area (n = 115). The follow-up was ˃ 2 years in all examined cases. A statistically significant correlation was found between tumor local recurrence and age (P = 0.03), Ets-1 expression (P ˂ 0.0001) and CD105 expression (P ˂ 0.0001).
  
  
  CONCLUSIONS
  Our data confirm that both Ets-1 and CD105 show promise as prognostic markers for local recurrence of NMSC. However, this statement is made with caution, and additional studies, with larger populations, are necessary to examine the correlation between these two markers and local recurrence. A better understanding of the pathogenesis of local recurrence in primary NMSC may result in potential therapeutic interventions.
authors.affiliation: Department of Plastic Surgery, "Andreas Syggros" Hospital, Athens, Greece.
authors.forename: Chrisostomos
authors.initials: C
authors.lastname: Chrisostomidis
authors.affiliation: 2nd Department of Propaedeutic Surgery, Medical School, Athens University, Athens, Greece.|Department of Plastic Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Petros
authors.initials: P
authors.lastname: Konofaos
authors.affiliation: Department of Plastic Surgery, "Andreas Syggros" Hospital, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Karypidis
authors.affiliation: 1st Department of Pathology, Medical School, Athens University, Athens, Greece.
authors.forename: Andreas
authors.initials: A
authors.lastname: Lazaris
authors.affiliation: 2nd Department of Propaedeutic Surgery, Medical School, Athens University, Athens, Greece.
authors.forename: Alkiviadis
authors.initials: A
authors.lastname: Kostakis
authors.affiliation: Department of Plastic Surgery, "Andreas Syggros" Hospital, Athens, Greece.|2nd Department of Propaedeutic Surgery, Medical School, Athens University, Athens, Greece.
authors.forename: Othon
authors.initials: O
authors.lastname: Papadopoulos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001707:Biopsy, Needle; D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D015331:Cohort Studies; D000071063:Endoglin; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D015513:Oncogene Proteins / Q000378:metabolism; D011379:Prognosis; D050784:Proto-Oncogene Protein c-ets-1 / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018709:Statistics, Nonparametric
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; C494041:ETS1 protein, human; D000071063:Endoglin; D015513:Oncogene Proteins; D050784:Proto-Oncogene Protein c-ets-1; D011956:Receptors, Cell Surface