title: Tongue cancer with mental retardation due to microcephaly: a clinical report.
abstract: Oral cancer in patients with mental retardation has not been reported in detail, although the literature on clinical management of oral malignancies in the general population is extensive. No clear consensus has been established regarding the management of oral cancer in patients with mental retardation. We present herein the case of a 32-year-old Japanese man with mental retardation due to microcephaly who presented with advanced tongue cancer. He was treated with three courses of chemotherapy using superselective intra-arterial infusion of cisplatin at 100 mg/m2 via the femoral artery (Seldinger method). No major complications were encountered, and complete response was achieved. The patient has shown no clinical or radiological evidence of local recurrence or distant metastases as of 22 months after the end of treatment. This case provides a basis for the future appropriate management of oral cancer in patients with mental retardation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kinki University School of Medicine, 377-2, Onohigashi, Osaka-Sayama, 589-8511, Japan. enomotoa@med.kindai.ac.jp.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Enomoto
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kinki University School of Medicine, 377-2, Onohigashi, Osaka-Sayama, 589-8511, Japan. t-nakatani@med.kindai.ac.jp.
authors.forename: Takanori
authors.initials: T
authors.lastname: Nakatani
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kinki University School of Medicine, 377-2, Onohigashi, Osaka-Sayama, 589-8511, Japan. e-morikage@med.kindai.ac.jp.
authors.forename: Eri
authors.initials: E
authors.lastname: Morikage
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kinki University School of Medicine, 377-2, Onohigashi, Osaka-Sayama, 589-8511, Japan. shimoide@med.kindai.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimoide
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kinki University School of Medicine, 377-2, Onohigashi, Osaka-Sayama, 589-8511, Japan. hamad@med.kindai.ac.jp.
authors.forename: Suguru
authors.initials: S
authors.lastname: Hamada
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology*; D008297:Male; D008831:Microcephaly / Q000150:complications*; D011379:Prognosis; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*