title: Sleep Disorders Reduce Health-Related Quality of Life in Multiple Sclerosis (Nottingham Health Profile Data in Patients with Multiple Sclerosis).
abstract: Quality of Life (QoL) is decreased in multiple sclerosis (MS), but studies about the impact of sleep disorders (SD) on health-related quality of Life (HRQoL) are lacking. From our original cohort, a cross-sectional polysomnographic (PSG) study in consecutive MS patients, we retrospectively analysed the previously unpublished data of the Nottingham Health Profile (NHP). Those MS patients suffering from sleep disorders (n = 49) showed significantly lower HRQoL compared to MS patients without sleep disorders (n = 17). Subsequently, we classified the patients into four subgroups: insomnia (n = 17), restless-legs syndrome, periodic limb movement disorder and SD due to leg pain (n = 24), obstructive sleep apnea (n = 8) and patients without sleep disorder (n = 17). OSA and insomnia patients showed significantly higher NHP values and decreased HRQoL not only for the sleep subscale but also for the "energy" and "emotional" area of the NHP. In addition, OSA patients also showed increased NHP values in the "physical abilities" area. Interestingly, we did not find a correlation between the objective PSG parameters and the subjective sleep items of the NHP. However, this study demonstrates that sleep disorders can reduce HRQoL in MS patients and should be considered as an important confounder in all studies investigating HRQoL in MS.
authors.affiliation: Interdisciplinary Center for Sleep Medicine, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany. CVeauthier@web.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Veauthier
authors.affiliation: NeuroCure Clinical Research Center, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany. gunnar.gaede@charite.de.|Department of Neurology, St. Joseph Hospital Berlin-Weissensee, 13088 Berlin, Germany. gunnar.gaede@charite.de.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Gaede
authors.affiliation: NeuroCure Clinical Research Center, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany. helena.radbruch@charite.de.
authors.forename: Helena
authors.initials: H
authors.lastname: Radbruch
authors.affiliation: CRO SOSTANA GmbH and Charité University Medicine Berlin, Wildensteiner Straße 27, 10318 Berlin, Germany. wernecke@sostana.de.
authors.forename: Klaus-Dieter
authors.initials: KD
authors.lastname: Wernecke
authors.affiliation: NeuroCure Clinical Research Center, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany. friedemann.paul@charite.de.|Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine Berlin, 10117 Berlin, Germany. friedemann.paul@charite.de.
authors.forename: Friedemann
authors.initials: F
authors.lastname: Paul
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000523:psychology; D011788:Quality of Life; D012148:Restless Legs Syndrome / Q000150:complications* / Q000523:psychology; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000523:psychology; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications* / Q000523:psychology
keywords: clinical neurophysiology; depression; health; insomnia; multiple sclerosis; pain; polysomnography; quality of life; restless legs syndrome; sleep disorders