title: Sweet's Syndrome: An Evidence-Based Report.
abstract: Sweet's syndrome encompasses a variety of neutrophilic dermatosis characterized by acute onset of erythematous, edematous, painful papules, plaques and nodules associated with systemic symptoms, peripheral blood leukocytosis and histological findings of dense neutrophilic infiltrate. Ten patients were diagnosed during a period of one year. The patient population consisted of 7 females and 3 males with mean age of 47.6 years ranging from 32 to 60 years. An associated disorder was observed in 6 patients which were diabetes, hypothyroidism, hypertension and inflammatory bowel disease. Two cases of pregnancy associated disease were observed. Cutaneous lesions consisted of erythematous plaques or nodules. Lesions were located mainly on the face, neck and upper extremities. All biopsy specimens demonstrated a dermal infiltrate composed predominantly of neutrophils. Seven patients were treated by oral corticosteroids and three by oral dapsone, all for a period of 6 weeks.
authors.affiliation: Department of Dermatology1/ Pathology2, Government Medical College, Srinagar, India.
authors.forename: Yasmeen J
authors.initials: YJ
authors.lastname: Bhat
authors.affiliation: Department of Dermatology, Government Medical College, Srinagar, India.
authors.forename: Iffat
authors.initials: I
authors.lastname: Hassan
authors.affiliation: Department of Dermatology, Government Medical College, Srinagar, India.
authors.forename: Peerzada
authors.initials: P
authors.lastname: Sajad
authors.affiliation: Department of Dermatology, Government Medical College, Srinagar, India.
authors.forename: Saniya
authors.initials: S
authors.lastname: Akhtar
authors.affiliation: Department of Pathology, Government Medical College, Srinagar, India.
authors.forename: Sheema
authors.initials: S
authors.lastname: Sheikh
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications; D007964:Leukocytosis / Q000150:complications; D008297:Male; D009504:Neutrophils; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000473:pathology; D016463:Sweet Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents; D003622:Dapsone