title: [Study on the efficacy and safety of sublingual immunotherapy with standardized dermatophagoides farinae drops for allergic rhinitis].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of the sublingual immunotherapy with dermatophagoides farinae drops on patients with allergic rhinitis.
  
  
  METHODS
  One hundred and twelve cases were collected from adult patients with dust-mite allergic rhinitis of our hospital who could adhere to treatment and regular follow-up. These patients were randomly allocated to receive either sublingual immunotherapy (SLIT group, n = 56) or medical treatment (Control group, n = 56). To evaluate the clinical efficacy by side effects which were registered, symptom and medication scores which were assessed and rhinoconjunctivitis quality of life questionnaire (RQLQ) which was completed in the baseline and two years after treatment.
  
  
  RESULTS
  Dropouts after the 2 years' treatment were 5 of SLIT group and 4 of Control group respectively. SLIT group induced the significant reductions on both the symptom scores (7.81 ± 3.14 to 3.89 ± 2.01, P < 0.0 1) and the medication scores (2.86 ± 0.75 to 0.44 ± 0.06, P < 0.01). Meanwhile, Control group induced the reductions on both the symptom scores (8.01 ± 3.32 to 5.20 ± 2.43) and the medication scores (2.95 ± 0.80 to 1.75 ± 0.40). There were significant differences (P< 0. 01) in symptom and medication scores between the two groups after 2-year treatment. The patients in SLIT group had fewer symptoms and lower intake of medication. There were statistically significant differences in RQLQ between SLIT group [19 (15,22)] and Control group [36 (26,47)] after two years treatment (Z = -5. 21, P < 0.01). SLIT group also had significant improvement in RQLQ (Z = -6.10, P < 0.01) between before and after the treatment. There were 4 patients who showed adverse reactions in SLIT group (3 occurred in increment period, and 1 occurred in the maintenance period). The incidence of adverse reactions was 7.14%. No severe systemic side effects were registered.
  
  
  CONCLUSIONS
  SLIT with standardized dermatophagoides farinae drops in China is safe and effective to patients with allergic rhinitis.
authors.forename: Shaopeng
authors.initials: S
authors.lastname: Huang
authors.forename: Xiufang
authors.initials: X
authors.lastname: Xie
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Lihua
authors.initials: L
authors.lastname: Wu
authors.forename: Ruiyu
authors.initials: R
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Shen
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D002681:China; D040001:Dermatophagoides farinae; D006801:Humans; D011788:Quality of Life; D065631:Rhinitis, Allergic / Q000188:drug therapy*; D063729:Sublingual Immunotherapy; D016896:Treatment Outcome
chemical_list: D039741:Antigens, Dermatophagoides