title: [Hedgehog signaling in the pathogenesis of neuro-oncology diseases].
abstract: The review summarizes current knowledge on the Hedgehog signaling pathway, its role in normal embryogenesis and/or initiation and progression of neuro-oncological diseases, especially of high-grade gliomas, the most malignant neuroepithelial tumors. The main proteins forming the Hedgehog signaling pathway include Shh, PTCH1, SMO, HHIP, SUFU and GLI1 isoforms. Effects of other signaling pathways on the family of transcription factors GLI and other proteins are described. The review summarizes modern data about the impact of the Hedgehog signaling pathway on proliferation, migration activity and invasiveness, and also on tumor neoangiogenesis and tumor cell chemoresistance. The role of the Hedgehog signaling pathway in origin of cancer stem cells and epithelial-mesenchymal transition is also analyzed. Some prospects for new anticancer drugs acting on components of the Hedgehog signaling pathway inhibitors are demonstrated.
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Cherepanov
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Baklaushev
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Gabashvili
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Shepeleva
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D016543:Central Nervous System Neoplasms / Q000378:metabolism* / Q000473:pathology; D019008:Drug Resistance, Neoplasm; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D000071676:Zinc Finger Protein GLI1
chemical_list: C400551:GLI1 protein, human; D053823:Hedgehog Proteins; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1
keywords: Hedgehog signaling pathway; Shh protein; glioblastoma multiforme; transcription factor GLI