title: New Eugenol Glucoside-based Derivative Shows Fungistatic and Fungicidal Activity against Opportunistic Candida glabrata.
abstract: A new series of glucosides modified in their saccharide units were synthesized, evaluated against Candida sp., and compared to prototype 1, an eugenol tetracetyl glucoside previously synthesized and shown to be active against Candida glabrata. Among the new glucosides, benzyl derivative 5 was the most promising, showing fungistatic activity at IC50 18.1 μm against Candida glabrata (threefold higher than fluconazole) and fungicidal activity with a low IC90 value of 36.2 μm. Moreover, the cytotoxic activity of compound 5 (CC50 : 580.9 μm), tested in peripheral blood mononuclear cells, suggests its potential as an agent to treat Candida glabrata infections, with a selectivity index of 32. The new eugenol glucoside 5 may be considered as a novel structural pattern in the development of new anti-Candida drugs.
authors.affiliation: Instituto de Química, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Alfenas, Brazil.
authors.forename: Thiago Belarmino
authors.initials: TB
authors.lastname: de Souza
authors.affiliation: Centro Universitário de Lavras, Rua Padre José Poggel, 506 Lavras, Brazil.
authors.forename: Keila Mercês de Oliveira
authors.initials: KM
authors.lastname: Brito
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Alfenas, Brazil.
authors.forename: Naiara Chaves
authors.initials: NC
authors.lastname: Silva
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Alfenas, Brazil.
authors.forename: Raissa Prado
authors.initials: RP
authors.lastname: Rocha
authors.affiliation: Departamento de Química, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627 Belo Horizonte, Brazil.
authors.forename: Grasiely Faria
authors.initials: GF
authors.lastname: de Sousa
authors.affiliation: Departamento de Química, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627 Belo Horizonte, Brazil.
authors.forename: Lucienir Pains
authors.initials: LP
authors.lastname: Duarte
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Alfenas, Brazil.
authors.forename: Luiz Felipe Leomil
authors.initials: LF
authors.lastname: Coelho
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Alfenas, Brazil.
authors.forename: Amanda Latércia Tranches
authors.initials: AL
authors.lastname: Dias
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Alfenas, Brazil.
authors.forename: Marcia Paranho
authors.initials: MP
authors.lastname: Veloso
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Alfenas, Brazil.
authors.forename: Diogo Teixeira
authors.initials: DT
authors.lastname: Carvalho
authors.affiliation: Instituto de Química, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Alfenas, Brazil.
authors.forename: Danielle Ferreira
authors.initials: DF
authors.lastname: Dias
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects*; D005054:Eugenol / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000935:Antifungal Agents; D005054:Eugenol
keywords: Candida glabrata; antifungal activity; eugenol; glucosides