title: Effects of Orally Administered Pyrroloquinoline Quinone Disodium Salt on Dry Skin Conditions in Mice and Healthy Female Subjects.
abstract: Pyrroloquinoline quinone (PQQ) is a coenzyme involved in the redox-cycling system. The supplemental use of PQQ has been examined based on its properties as an antioxidant and redox modulator. Although an animal study on deficiency of PQQ suggested that PQQ contributes to skin conditions, its efficacy in humans has not been reported. The present study aimed to investigate the effects of orally administered PQQ on skin moisture, viscoelasticity, and transepidermal water loss (TEWL) both in dry skin mouse models and in healthy female subjects with a subjective symptom of dry skin. In our dry skin mouse model study, oral intake of PQQ (0.0089%, w/w, in the diet for 6 wk) significantly decreased the number of mast cells in the dermis and the number of CD3⁺ T-cells in the epidermis. In our human study, oral intake of PQQ (20 mg/d for 8 wk) significantly inhibited the increase in TEWL on the forearm. Finally, subject questionnaires showed positive impressions for the improvement of skin conditions. These results suggest that oral intake of PQQ improves skin conditions both in female subjects with dry skin and in mice with a compromised skin barrier function.
authors.affiliation: Mitsubishi Gas Chemical Company, Inc.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakano
authors.forename: Ayako
authors.initials: A
authors.lastname: Kamimura
authors.forename: Fumiko
authors.initials: F
authors.lastname: Watanabe
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kamiya
authors.forename: Daisuke
authors.initials: D
authors.lastname: Watanabe
authors.forename: Etsushi
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Fukagawa
authors.forename: Keiji
authors.initials: K
authors.lastname: Hasumi
authors.forename: Eriko
authors.initials: E
authors.lastname: Suzuki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017252:CD3 Complex / Q000378:metabolism; D004548:Elasticity / Q000187:drug effects; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D008812:Mice, Hairless; D010084:Oxidation-Reduction / Q000187:drug effects; D045542:PQQ Cofactor / Q000008:administration & dosage / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000503:physiopathology; D012871:Skin Diseases / Q000188:drug therapy*; D014783:Viscosity / Q000187:drug effects; D014870:Water Loss, Insensible / Q000187:drug effects*
chemical_list: D017252:CD3 Complex; D045542:PQQ Cofactor