title: Chitosan coatings to control release and target tissues for therapeutic delivery.
abstract: The natural biopolymer chitosan has versatile applications in therapeutic delivery. Coating drug delivery matrices or biomaterials with chitosan offers several advantages in drug delivery, including control of drug release, slowing degradation rate and improving biocompatibility. Advanced uses of chitosan in coating form include targeting drug delivery vehicles to specific tissue as well as providing a stimulus-controlled release response. The present review summarizes the current applications of chitosan coatings in the context of different biomaterial delivery technologies, as well as future directions of chitosan coatings for drug delivery technologies under development.
authors.affiliation: Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building; Memphis, TN 38122, USA.
authors.forename: Jessica Amber
authors.initials: JA
authors.lastname: Jennings
authors.affiliation: Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building; Memphis, TN 38122, USA.
authors.forename: Carlos Montez
authors.initials: CM
authors.lastname: Wells
authors.affiliation: Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building; Memphis, TN 38122, USA.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: McGraw
authors.affiliation: Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building; Memphis, TN 38122, USA.
authors.forename: Diego A
authors.initials: DA
authors.lastname: Velasquez Pulgarin
authors.affiliation: Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building; Memphis, TN 38122, USA.
authors.forename: Marsalas D
authors.initials: MD
authors.lastname: Whitaker
authors.affiliation: Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building; Memphis, TN 38122, USA.
authors.forename: Reginald L
authors.initials: RL
authors.lastname: Pruitt
authors.affiliation: Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building; Memphis, TN 38122, USA.
authors.forename: Joel David
authors.initials: JD
authors.lastname: Bumgardner
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D018014:Gene Transfer Techniques; D006801:Humans; D007700:Kinetics; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D048271:Chitosan