title: Hematopoietic pre-B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion.
abstract: Hematopoietic pre-B cell leukemia transcription factor interacting protein (HPIP) has been shown to play an important role in the development and progression of some cancers. However, the role of HPIP in gastric cancer (GC) is unclear. Here, we show that HPIP is upregulated in most GC patients and promotes GC cell proliferation, migration, and invasion. In GC patients, HPIP positively associates with tumor size and nodal metastasis, and negatively associates with tumor differentiation. Hematopoietic pre-B cell leukemia transcription factor interacting protein increases GC cell proliferation through activation of G1 /S and G2 /M cell cycle transitions, accompanied by a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. Hematopoietic pre-B cell leukemia transcription factor interacting protein enhances GC cell migration and invasion, and modulates epithelial-mesenchymal transition, which plays a key role in cancer cell migration and invasion. These data underscore the critical role of HPIP in GC cell proliferation and progression and suggest that HPIP inhibition may be a useful therapeutic strategy for GC treatment.
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.|Department of Colorectal Surgery, the Second Artillery General Hospital, Beijing, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Colorectal Surgery, the Second Artillery General Hospital, Beijing, China.
authors.forename: Yunjing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Jinjing
authors.initials: J
authors.lastname: Lv
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Zhongyi
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Hong
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Ji
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Quanbo
authors.initials: Q
authors.lastname: Ji
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Mei
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Gastrointestinal Oncology, Shandong Cancer Hospital and Institute, Jinan, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Qinong
authors.initials: Q
authors.lastname: Ye
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D056750:Cyclin A1 / Q000096:biosynthesis; D056744:Cyclin B1 / Q000096:biosynthesis; D019938:Cyclin D1 / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D059585:G1 Phase Cell Cycle Checkpoints / Q000235:genetics; D059565:G2 Phase Cell Cycle Checkpoints / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D034741:RNA, Small Interfering; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: C503745:CCNA1 protein, human; C534699:CCNB1 protein, human; C530104:CCND1 protein, human; D056750:Cyclin A1; D056744:Cyclin B1; D004268:DNA-Binding Proteins; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering; C083400:PBX1 protein, human; D019938:Cyclin D1
keywords: Cell growth; EMT; HPIP; gastric cancer; migration and invasion