title: Endovascular stroke therapy with the Aperio thrombectomy device.
abstract: BACKGROUND
  The pharmaceutical therapy for acute ischemic stroke has shortcomings in reopening large vessels and dissolving long thrombi, and endovascular treatment has been found to provide added value. The Aperio thrombectomy device showed promising results in an experimental study. The purpose of this study was to evaluate the device clinically.
  
  
  METHODS
  119 patients with acute stroke were treated in nine centers using the Aperio thrombectomy device. Target vessel, diameter, thrombus length, procedure time, recanalization, number of deployments, additional use of anticoagulants, complications, and the use of additional devices were assessed.
  
  
  RESULTS
  The median thrombus length was 15 mm (range 1.5-20 mm) and the average time from device insertion to recanalization was 30 min (range 5-120 min). Blood flow restoration (Thrombolysis In Cerebral Infarction (TICI) 2-3) was achieved in 85%. In the majority of cases complete clot removal was achieved (TICI 0, 12%; TICI 1, 2%; TICI 2a, 14%; TICI 2b, 18%; TICI 3, 53%). The median number of deployments was 2 (range 1-6). Twelve procedural complications (10%) occurred.
  
  
  CONCLUSIONS
  The Aperio thrombectomy device seems to be an effective and adequately safe tool for reopening occluded cerebral arteries in the setting of acute stroke.
authors.affiliation: Institute for Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Kallenberg
authors.affiliation: Department of Neuroradiology, University Würzburg, Würzburg, Germany.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Solymosi
authors.affiliation: Department of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Taschner
authors.affiliation: Institute for Neuroradiology, University Medical Center Frankfurt, J W Goethe-University Frankfurt, Frankfurt, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Berkefeld
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Schlamann
authors.affiliation: Department of Radiology and Neuroradiology, UKSH Campus Kiel, Kiel, Germany.
authors.forename: Olav
authors.initials: O
authors.lastname: Jansen
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Städtisches Klinikum Karlsruhe gGmbH, Karlsruhe, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Arnold
authors.affiliation: Clinic for Radiology and Neuroradiology, Klinikum Christophsbad, Göppingen, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Tomandl
authors.affiliation: Institute for Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Knauth
authors.affiliation: Section of Neuroradiology, Institute for Diagnostic and Interventional Radiology, University Düsseldorf, Düsseldorf, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Turowski
mesh_terms: D015901:Angiography, Digital Subtraction; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000601:surgery; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000601:surgery; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D020521:Stroke / Q000601:surgery*; D013525:Surgical Instruments; D017131:Thrombectomy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants
keywords: Brain; Device; Stroke; Thrombectomy