title: Natural Rumen-Derived trans Fatty Acids Are Associated with Metabolic Markers of Cardiac Health.
abstract: Evidence suggests that industrial trans fatty acids (iTFA) impair lipid profiles while ruminant trans fatty acids (rTFA) may lower insulin resistance and blood pressure. The objective of this article was to determine if the plasma phospholipid percentage of rTFA is associated with a favorable cardiometabolic profile. We collected fasting blood samples from 200 individuals from Quebec city (QC, Canada) aged from 18 to 55 years old, including 100 obese (BMI ≥ 30 kg m(-2)) and 100 non-obese (BMI < 30 kg m(-2)) men and women. Fatty acid levels in plasma phospholipids were determined using gas chromatography. After separating the subjects into two groups, according to the median percentage of rTFA in plasma phospholipids, participants in the group with higher percentages of rTFA (0.86 ± 0.24 %) had higher adiponectin levels (p = 0.01) and a lower blood pressure (systolic, p = 0.005; diastolic, p = 0.04). In contrast, concentrations in plasma phospholipids of elaidic acid, a major iTFA, are positively correlated with glycemia in non-obese subjects (p = 0.01) and with both triacylglycerol (TAG) (p = 0.0007) and total cholesterol (TC) (p = 0.009) in obese subjects. These data suggest that rTFA may have beneficial effects on cardiometabolic risk factors conversely to their counterpart iTFA. Dietary sources of TFA should be taken into account in future cardiometabolic studies.
authors.affiliation: Endocrinology and Nephrology, T-4-55B, CHU de Québec Research Center, CHUL-2705, boul. Laurier, Québec, QC, G1V 4G2, Canada.
authors.forename: Marine S
authors.initials: MS
authors.lastname: Da Silva
authors.forename: Pierre
authors.initials: P
authors.lastname: Julien
authors.forename: Louis
authors.initials: L
authors.lastname: Pérusse
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Vohl
authors.forename: Iwona
authors.initials: I
authors.lastname: Rudkowska
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D002170:Canada / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D003611:Dairy Products / Q000032:analysis; D004041:Dietary Fats / Q000378:metabolism*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008460:Meat / Q000032:analysis; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism; D019301:Oleic Acid / Q000097:blood; D009829:Oleic Acids; D012307:Risk Factors; D012417:Rumen / Q000378:metabolism*; D044242:Trans Fatty Acids / Q000145:classification / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004041:Dietary Fats; D009829:Oleic Acids; D044242:Trans Fatty Acids; D019301:Oleic Acid; C011459:elaidic acid