title: Effects of a New Glutamic Acid Derivative on Myocardial Contractility of Stressed Animals under Conditions of Nitric Oxide Synthesis Blockade.
abstract: Glufimet (glutamic acid derivative) in a dose of 28.7 mg/kg limited the reduction of the cardiac functional reserve in animals subjected to 24-h stress under conditions of nonselective NO synthase blockade with L-NAME (10 mg/kg). Adrenoreactivity and increased afterload tests showed that the increment of myocardial contraction/relaxation rates, left-ventricular pressure, and HR were significantly higher in glufimet-treated stressed animals with NO synthesis blockade than in animals which received no glufimet. The efficiency of glufimet was higher than that of phenibut (the reference drug).
authors.affiliation: Volgograd State Medical University, Volgograd, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: N V
authors.initials: NV
authors.lastname: Sadikova
authors.forename: V M
authors.initials: VM
authors.lastname: Berestovitskaya
authors.forename: O S
authors.initials: OS
authors.lastname: Vasil'eva
mesh_terms: D000818:Animals; D005260:Female; D018698:Glutamic Acid / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats
chemical_list: D009569:Nitric Oxide; D018698:Glutamic Acid