title: Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review.
abstract: BACKGROUND
  Eccrine porocarcinoma (EPC) is a rare malignant tumor of the eccrine sweat gland. It is a potentially fatal neoplasm that is locally aggressive and commonly recurs. Wide surgical excision has traditionally been the treatment of choice and is curative in approximately 70-80% of cases. The disease is metastatic to lymph nodes and distant sites in 20% and 10% of cases, respectively. Metastatic EPC has not shown any great response to adjuvant chemotherapy or radiation.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the efficacy of Mohs micrographic surgery (MMS) for EPC as an alternative to wide local excision.
  
  
  METHODS
  Five patients diagnosed with EPS between 2011 and 2014 at the University of Louisville and treated with MMS were studied. Recurrence-free periods subsequent to the treatment of EPC with MMS were measured.
  
  
  RESULTS
  The five patients with EPC treated by MMS remained recurrence-free for a mean of 11 months (range: 2-26 months).
  
  
  CONCLUSIONS
  Mohs micrographic surgery is a highly effective treatment for EPC. Given the high rate of recurrence, propensity for lymph node metastases, and the often ineffective options for treating advanced disease, MMS should be considered in the treatment of all cases of EPC.
authors.affiliation: Division of Dermatology, School of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: William James
authors.initials: WJ
authors.lastname: Tidwell
authors.affiliation: College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Mayer
authors.affiliation: Division of Dermatology, School of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Janine
authors.initials: J
authors.lastname: Malone
authors.affiliation: Division of Dermatology, School of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Courtney
authors.initials: C
authors.lastname: Schadt
authors.affiliation: Division of Dermatology, School of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Brown
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D015331:Cohort Studies; D057090:Eccrine Porocarcinoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015580:Mohs Surgery / Q000379:methods*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013544:Sweat Gland Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome