title: Safe and symptomatic medicinal use of surface-functionalized Mn3O4 nanoparticles for hyperbilirubinemia treatment in mice.
abstract: OBJECTIVE
  Testing the potential of citrate-capped Mn3O4 nanoparticles (NPs) as a therapeutic agent for alternative rapid treatment of hyperbilirubinemia through direct removal of bilirubin (BR) from blood in mice.
  
  
  METHODS
  NPs were synthesized and the mechanism of BR degradation in presence and absence of biological macromolecules were characterized in vitro. To test the in vivo BR degradation ability of NPs, CCl4-intoxicated mice were intraperitoneally injected with NPs.
  
  
  RESULTS
  We demonstrated ultrahigh efficacy of the NPs in symptomatic treatment of hyperbilirubinemia for rapid reduction of BR in mice compared with conventional medicine silymarin without any toxicological implications.
  
  
  CONCLUSIONS
  These findings may pave the way for practical clinical use of the NPs as safe medication of hyperbilirubinemia in human subjects.
authors.affiliation: Department of Chemical, Biological & Macromolecular Sciences, S N Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India.
authors.forename: Nabarun
authors.initials: N
authors.lastname: Polley
authors.affiliation: Department of Physics, Jadavpur University, 188, Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata 700032, India.
authors.forename: Srimoyee
authors.initials: S
authors.lastname: Saha
authors.affiliation: Department of Chemical, Biological & Macromolecular Sciences, S N Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: Department of Physics, Jadavpur University, 188, Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata 700032, India.
authors.forename: Somtirtha
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: Research & Development Division, Dey's Medical Stores (Mfg.) Ltd, 62, Bondel Road, Ballygunge, Kolkata 700019, India.
authors.forename: Soumendra
authors.initials: S
authors.lastname: Darbar
authors.affiliation: Department of Physics, Jadavpur University, 188, Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata 700032, India.
authors.forename: Sukhen
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Chemical, Biological & Macromolecular Sciences, S N Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India.
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Pal
mesh_terms: D000818:Animals; D002942:Circular Dichroism; D006932:Hyperbilirubinemia / Q000188:drug therapy* / Q000473:pathology; D017895:Manganese Compounds / Q000627:therapeutic use*; D051379:Mice; D053758:Nanoparticles; D010087:Oxides / Q000627:therapeutic use*; D013499:Surface Properties
chemical_list: D017895:Manganese Compounds; D010087:Oxides; C027424:manganese oxide
keywords: Mn-based functionalized nanoparticles; hyperbilirubinemia; mice model; nanomedicine; nanotherapy of jaundice