title: Exploration of individuality in drug metabolism by high-throughput metabolomics: The fast line for personalized medicine.
abstract: In many cases, individuality in metabolism of a drug is a reliable predictor of the drug efficacy/safety. Modern high-throughput metabolomics is an ideal instrument to track drug metabolism in an individual after treatment. Productivity and low cost of the metabolomics are sufficient to analyse a large cohort of patients to explore individual variations in drug metabolism and to discover drug metabolic biomarkers indicative of drug efficacy/safety. The only potential disadvantage of metabolomics becoming a routine clinical procedure is a need to treat the patient once before making a prognosis. However, in many clinical applications this would not be a limitation. Here, we explore current opportunities and challenges for translating high-throughput metabolomics into the platform for personalized medicine.
authors.affiliation: Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences, Pogodinskaya Street, Moscow, Russia.
authors.forename: Oxana
authors.initials: O
authors.lastname: Trifonova
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester, UK.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Knight
authors.affiliation: Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences, Pogodinskaya Street, Moscow, Russia.
authors.forename: Andrey
authors.initials: A
authors.lastname: Lisitsa
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester, UK.
authors.forename: Gerry
authors.initials: G
authors.lastname: Melino
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester, UK. Electronic address: aa668@le.ac.uk.
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Antonov
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D007206:Individuality; D055432:Metabolomics / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D057285:Precision Medicine / Q000379:methods*
chemical_list: D015415:Biomarkers; D004364:Pharmaceutical Preparations