title: Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population.
abstract: Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis in many parts of the world. Although previous genome-wide association studies (GWAS) identified the major susceptibility loci for IgAN, the causal genes currently remain unknown. We performed a GWAS using 23 465 microsatellite (MS) markers to identify genes related to IgAN in a Japanese population. A pooled sample analysis was conducted in three-stage screenings of three independent case-control populations, and after the final step of individual typing, 11 markers survived. Of these, we focused on two regions on 6p21 and 12q21 because they (i) showed the strongest relationship with IgAN, and (ii) appeared to be highly relevant to IgAN in view of several previous studies. These regions contained the HLA, TSPAN8 and PTPRR genes. This study on GWAS, using >20 000 MS markers, provides a new approach regarding susceptible genes for IgAN for investigators seeking new tools for the prevention and treatment of IgAN.
authors.affiliation: Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.|Department of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Sanae
authors.initials: S
authors.lastname: Saka
authors.affiliation: Department of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Hirawa
authors.affiliation: The Institute of Medical Science, Tokai University, Isehara, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
authors.affiliation: Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yatsu
authors.affiliation: Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirukawa
authors.affiliation: Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yamamoto
authors.affiliation: Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Matsusaka
authors.affiliation: Nakayamadera Imai Clinic, Takarazuka, Japan.|Department of Nephrology, Fujita Health University, Toyoake, Japan.
authors.forename: Enyu
authors.initials: E
authors.lastname: Imai
authors.affiliation: Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
authors.affiliation: Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Endoh
authors.affiliation: Department of Ethics, Shinshu Univeristy, Nagano, Japan.|Departments of Pediatrics and Medicine, Vanderbilt University, Nashville, TN, USA.
authors.forename: Iekuni
authors.initials: I
authors.lastname: Ichikawa
authors.affiliation: Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Umemura
authors.affiliation: The Institute of Medical Science, Tokai University, Isehara, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
mesh_terms: D044466:Asian People; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D018895:Microsatellite Repeats; D054634:Receptor-Like Protein Tyrosine Phosphatases, Class 7 / Q000235:genetics*; D059470:Tetraspanins / Q000235:genetics*
chemical_list: D006680:HLA Antigens; C065609:TSPAN8 protein, human; D059470:Tetraspanins; C513469:PTPRR protein, human; D054634:Receptor-Like Protein Tyrosine Phosphatases, Class 7