title: Human Leukocyte Antigen Class II Alleles Are Associated with Hepatitis C Virus Natural Susceptibility in the Chinese Population.
abstract: Human leukocyte antigen (HLA) class II molecule influences host antigen presentation and anti-viral immune response. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) within HLA class II gene were associated with different clinical outcomes of hepatitis C virus (HCV) infection. Three HLA class II SNPs (rs3077, rs2395309 and rs2856718) were genotyped by TaqMan assay among Chinese population, including 350 persistent HCV infection patients, 194 spontaneous viral clearance subjects and 973 HCV-uninfected control subjects. After logistic regression analysis, the results indicated that the rs2856718 TC genotype was significantly associated with the protective effect of the HCV natural susceptibility (adjusted OR: 0.712, 95% CI: 0.554-0.914) when compared with reference TT genotype, and this remained significant after false discovery rate (FDR) correction (p = 0.024). Moreover, the protective effect of rs2856718 was observed in dominant genetic models (adjusted OR: 0.726, 95% CI: 0.574-0.920), and this remained significant after FDR correction (p = 0.024). In stratified analysis, a significant decreased risk was found in rs2856718C allele in the male subgroup (adjusted OR: 0.778, 95% CI: 0.627-0.966) and hemodialysis subgroup (adjusted OR: 0.713, 95% CI: 0.552-0.921). Our results indicated that the genetic variations of rs2856718 within the HLA-DQ gene are associated with the natural susceptibility to HCV infection among the Chinese population.
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. njym08@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Yue
authors.affiliation: Department of Acute Infection Diseases, Jiangsu Province Center for Disease Prevention and Control, Nanjing 210009, China. xuke923@163.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. wumengping1990@163.com.
authors.forename: Meng-Ping
authors.initials: MP
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. asian_peace@126.com.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Han
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. hp19880310@163.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. zhihangpeng@njmu.edu.cn.
authors.forename: Zhi-Hang
authors.initials: ZH
authors.lastname: Peng
authors.affiliation: School of Nursing, Nanjing Medical University, Nanjing 211166, China. wangjie.nj@gmail.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. sujing@njmu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. rongbinyu@njmu.edu.cn.
authors.forename: Rong-Bin
authors.initials: RB
authors.lastname: Yu
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. dr-lijun@vip.sina.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. zhangyunvip@126.com.|Institute of Epidemiology and Microbiology, Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, China. zhangyunvip@126.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000235:genetics* / Q000821:virology*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D000949:Histocompatibility Antigens Class II
keywords: hepatitis C virus; human leukocyte antigen; infection; outcome; polymorphism