title: Use of anodized titanium alloy as drug carrier: Ibuprofen as model of drug releasing.
abstract: The use of osteoarticular implants has improved the quality of life of millions of patients. In this work nanotubular structures tailored made on Ti6Al4V substrates was used as drug delivery system of ibuprofen as a proof of concept. Three different nanotubular films with different sizes and forms (NT, NT+ and NTb) were analysed. Samples were soaked in a solution of 660 mg ibuprofen/20 mL n-pentane. The ibuprofen release in aqueous medium was evaluated by liquid chromatography reversed-phase (RP-HPLC). To calculate the observed constant k, the amount of ibuprofen released was plotted versus the time using linear regression according to the zero-order, first-order, second-order and Higuchi model. The release of ibuprofen was constant and independent of the concentration. The kinetic constant obtained was 0.021 (NT), 0.022 (NT+) and 0.013 (NTb) being the correlation factor of 0.98 (zero-order) where the maximum correlation factor was reached. These results indicate that the delivery process from NT and NT+ is similar and slower that NTb. In all the cases was inside the therapeutically range. These results showed the potential of these modifications in order to develop implants that can carry different molecules of medical importance.
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain.
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Doadrio
authors.affiliation: Departamento de Ingeniería de superficies Corrosión y Durabilidad, Centro Nacional de Investigaciones Metalúrgicas, CENIM-CSIC, Avda. Gregorio del Amo, 8, 28040 Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Conde
authors.affiliation: Departamento de Ingeniería de superficies Corrosión y Durabilidad, Centro Nacional de Investigaciones Metalúrgicas, CENIM-CSIC, Avda. Gregorio del Amo, 8, 28040 Madrid, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Arenas
authors.affiliation: Departamento de Ingeniería de superficies Corrosión y Durabilidad, Centro Nacional de Investigaciones Metalúrgicas, CENIM-CSIC, Avda. Gregorio del Amo, 8, 28040 Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Hernández-López
authors.affiliation: Departamento de Ingeniería de superficies Corrosión y Durabilidad, Centro Nacional de Investigaciones Metalúrgicas, CENIM-CSIC, Avda. Gregorio del Amo, 8, 28040 Madrid, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: de Damborenea
authors.affiliation: Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, UAM, Av. Reyes Catolicos 2, Madrid, 28040, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Pérez-Jorge
authors.affiliation: Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, UAM, Av. Reyes Catolicos 2, Madrid, 28040, Spain. Electronic address: jestebanmoreno@gmail.com.
authors.forename: Jaime
authors.initials: J
authors.lastname: Esteban
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Vallet-Regí
mesh_terms: D000497:Alloys; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D007052:Ibuprofen / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D004337:Drug Carriers; C031462:titanium alloy (TiAl6V4); C009495:titanium dioxide; D014025:Titanium; D007052:Ibuprofen
keywords: Anodization; Ibuprofen; Nanotubes; Releasing; Ti6Al4V