title: Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.
abstract: Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respective receptor complexes they signal mainly via the JAK/STAT pathway. Besides sharing many biochemical properties, both display divergent physiological functions. This review summarizes aspects of cytokine transcription and biosynthesis, cytokine-receptor interactions, cross-species activities, signal transduction and physiology delineated from recent findings in genetic mouse models for both cytokines, OSM and IL-31.
authors.affiliation: University Hospital Würzburg, Department of Internal Medicine II, Hepatology Research Laboratory, Grombühlstr. 12, 97080 Würzburg, Germany. Electronic address: Hermanns_H@ukw.de.
authors.forename: Heike M
authors.initials: HM
authors.lastname: Hermanns
mesh_terms: D000818:Animals; D006801:Humans; D007378:Interleukins / Q000235:genetics / Q000276:immunology*; D053612:Janus Kinases / Q000235:genetics / Q000276:immunology; D051379:Mice; D053683:Oncostatin M / Q000235:genetics / Q000276:immunology*; D053681:Oncostatin M Receptor beta Subunit / Q000235:genetics / Q000276:immunology*; D050791:STAT Transcription Factors / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*
chemical_list: C502187:IL31 protein, human; D007378:Interleukins; C508351:OSM protein, human; C508348:OSMR protein, human; D053681:Oncostatin M Receptor beta Subunit; C508352:Osm protein, mouse; C508349:Osmr protein, mouse; D050791:STAT Transcription Factors; C502588:interleukin-31, mouse; D053683:Oncostatin M; D053612:Janus Kinases
keywords: Cytokines; Inflammation; Interleukin-31; Oncostatin M; Signal transduction