title: In vitro and in vivo evaluation of a shape memory polymer foam-over-wire embolization device delivered in saccular aneurysm models.
abstract: Current endovascular therapies for intracranial saccular aneurysms result in high recurrence rates due to poor tissue healing, coil compaction, and aneurysm growth. We propose treatment of saccular aneurysms using shape memory polymer (SMP) foam to improve clinical outcomes. SMP foam-over-wire (FOW) embolization devices were delivered to in vitro and in vivo porcine saccular aneurysm models to evaluate device efficacy, aneurysm occlusion, and acute clotting. FOW devices demonstrated effective delivery and stable implantation in vitro. In vivo porcine aneurysms were successfully occluded using FOW devices with theoretical volume occlusion values greater than 72% and rapid, stable thrombus formation. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1407-1415, 2016.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, Texas.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Boyle
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, Texas.
authors.forename: Todd L
authors.initials: TL
authors.lastname: Landsman
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, Texas.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Wierzbicki
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, Texas.
authors.forename: Landon D
authors.initials: LD
authors.lastname: Nash
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, Texas.
authors.forename: Wonjun
authors.initials: W
authors.lastname: Hwang
authors.affiliation: Texas Institute for Preclinical Studies, Texas A&M University, College Station, Texas.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Miller
authors.affiliation: Texas Institute for Preclinical Studies, Texas A&M University, College Station, Texas.
authors.forename: Egemen
authors.initials: E
authors.lastname: Tuzun
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, Texas.
authors.forename: Sayyeda M
authors.initials: SM
authors.lastname: Hasan
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, Texas. djmaitland@tamu.edu.
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Maitland
mesh_terms: D000783:Aneurysm / Q000628:therapy*; D000818:Animals; D063566:Biodegradable Plastics / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D013552:Swine
chemical_list: D063566:Biodegradable Plastics
keywords: SMP foam; aneurysm; embolization; porcine model; shape memory polymer