title: [Cutaneous manifestations of cystic fibrosis in an infant: acrodermatitis enteropathica and gray hair].
abstract: BACKGROUND
  Cutaneous manifestations at the time of CF diagnosis are rare.
  
  
  OBJECTIVE
  To describe the case of an infant with an unusual cutaneous presentation of cystic fibrosis.
  
  
  METHODS
  The case is presented of an infant with delayed physical growth at two months, and at the age of four months, presented with a skin rash and gray hair. Tests revealed the presence of hypoproteinemia and anemia, with the diagnosis of Cystic Fibrosis being confirmed by genetic testing. The rash was completely resolved after pancreatic enzyme replacement therapy. This is the second gray hair case reported in children with this disease.
  
  
  CONCLUSIONS
  Metabolic diseases such as cystic fibrosis should be suspected in malnourished children who develop skin disorders.
authors.affiliation: Unidad de Dermatología Infantil, Hospital de Niños Dr. Exequiel González Cortés, Santiago, Chile. Electronic address: paulayarmuch@hotmail.com.
authors.forename: G Paula
authors.initials: GP
authors.lastname: Yarmuch
authors.affiliation: Unidad de Dermatología Infantil, Hospital de Niños Dr. Exequiel González Cortés, Santiago, Chile.
authors.forename: R Ximena
authors.initials: RX
authors.lastname: Chaparro
authors.affiliation: Unidad de Dermatología Infantil, Hospital de Niños Dr. Exequiel González Cortés, Santiago, Chile.
authors.forename: S Cecilia
authors.initials: SC
authors.lastname: Fischer
mesh_terms: D000169:Acrodermatitis / Q000209:etiology*; D000740:Anemia / Q000209:etiology; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis*; D056947:Enzyme Replacement Therapy / Q000379:methods*; D005260:Female; D005820:Genetic Testing / Q000379:methods; D006200:Hair Color; D006801:Humans; D007019:Hypoproteinemia / Q000209:etiology; D007223:Infant; D015032:Zinc / Q000172:deficiency*
chemical_list: D015032:Zinc
keywords: Acrodermatitis Enteropathica; Acrodermatitis enteropática; Cystic Fibrosis; Exanthema; Gray Hair; exantema; fibrosis quística; pelo gris