title: Loss of Dopamine Transporter Binding and Clinical Symptoms in Dementia With Lewy Bodies.
abstract: BACKGROUND
  Little is known about the underlying mechanisms of clinical symptoms in dementia with Lewy bodies. The aim of this study was to explore the association between loss of striatal dopamine transporter binding and symptoms in dementia with Lewy bodies.
  
  
  METHODS
  Thirty-five patients with dementia with Lewy bodies underwent single-photon emission computerized tomography brain imaging with N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane ([(123) I]FP-CIT). Associations between striatal binding ratios and motor (UPDRS), psychiatric (Neuropsychiatric Inventory; [NPI]), and cognitive (Mini-Mental State Examination [MMSE] and neuropsychological tests) symptoms were assessed by linear regression analysis.
  
  
  RESULTS
  The explorative analysis showed that the motor UPDRS was negatively associated with putamen dopamine transporter binding, whereas no association with striatal dopamine transporter binding was found for total NPI, hallucinations, apathy, depression, anxiety, and MMSE scores. However, in post-hoc analysis, executive impairment was positively associated with dopamine transporter loss after adjustment of age and gender.
  
  
  CONCLUSIONS
  Dopamine deficiency in patients with dementia with Lewy bodies was associated with severity of motor symptoms, but did not correlate significantly with ratings of neurobehavioral disturbances or overall cognition.
authors.affiliation: Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
authors.forename: Françoise J
authors.initials: FJ
authors.lastname: Siepel
authors.affiliation: Department of Research, Stavanger University Hospital, Stavanger, Norway.
authors.forename: Ingvild
authors.initials: I
authors.lastname: Dalen
authors.affiliation: Department of Radiology, Haukeland University Hospital, Bergen, Norway.|Department of Physics and Technology, University of Bergen, Bergen, Norway.
authors.forename: Renate
authors.initials: R
authors.lastname: Grüner
authors.affiliation: Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Booij
authors.affiliation: TIPS-Regional Center for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norway.|Faculty of Social Sciences, University of Stavanger, Stavanger, Norway.
authors.forename: Kolbjørn S
authors.initials: KS
authors.lastname: Brønnick
authors.affiliation: Department of Nuclear Medicine, Stavanger University Hospital, Stavanger, Norway.
authors.forename: Tirza C
authors.initials: TC
authors.lastname: Buter
authors.affiliation: Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.|Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institute, Stockholm, Sweden.
authors.forename: Dag
authors.initials: D
authors.lastname: Aarsland
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology*; D008609:Mental Status Schedule; D009043:Motor Activity / Q000502:physiology; D011485:Protein Binding / Q000187:drug effects; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes / Q000493:pharmacokinetics
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D005462:Fluorine Radioisotopes; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
keywords: Lewy body; SPECT; [123I]FP-CIT; dementia; dopamine transporter