title: Resected tumor seeding in stomach wall due to endoscopic ultrasonography-guided fine needle aspiration of pancreatic adenocarcinoma.
abstract: Endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain. Examinations revealed a 20 mm mass in the pancreatic body, for which EUS-FNA was performed. The cytology of the lesion was adenocarcinoma, and the stage of the cancer was T3N0M0. The patient underwent surgery with curative intent, followed by adjuvant chemotherapy with S-1. An enlarging gastric submucosal tumor was found on gastroscopy at 28 mo after surgery accompanied by a rising level of CA19-9. Biopsy result was adenocarcinoma, consistent with a pancreatic primary tumor. Tumor seeding after EUS-FNA was strongly suspected. The patient underwent surgical resection of the gastric tumor with curative intent. The pathological result of the resected gastric specimen was adenocarcinoma with a perfectly matched mucin special stain result with the previously resected pancreatic cancer. This is the first case report of tumor seeding after EUS-FNA which was surgically resected and inspected pathologically.
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tomonari
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Katanuma
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Matsumori
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamazaki
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Itsuki
authors.initials: I
authors.lastname: Sano
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Ryuki
authors.initials: R
authors.lastname: Minami
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Sen-yo
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ikarashi
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kin
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Yane
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Shinohara
authors.affiliation: Akiko Tomonari, Akio Katanuma, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Maguchi
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D004338:Drug Combinations; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000009:adverse effects*; D005743:Gastrectomy; D006801:Humans; D008297:Male; D009366:Neoplasm Seeding; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000628:therapy; D013274:Stomach Neoplasms / Q000556:secondary* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid
keywords: Endoscopic ultrasonography-guided fine needle aspiration; Pancreatic cancer; Tumor seeding