title: Relationship between pseudoexfoliation syndrome and erectile dysfunction: a possible cause of endothelial dysfunction for development of erectile dysfunction.
abstract: OBJECTIVE
  Pseudoexfoliation syndrome (PES) is a common age-related fibrillopathy related to accumulation of pseudoexfoliation material (PEM) in certain places in the body, especially blood vessels. Erectile dysfunction (ED) is another condition related to vascular pathology and in this study it is aimed to identify the relationship between ED and PES.
  
  
  METHODS
  Data of 92 patients were investigated. There were 34 patients in the PES group and 58 patients in the control group. Presence of diabetes, hypertension, smoking history, BMI, and serum levels of lipids and testosterone were recorded. The groups were compared for ED rates and severity. Also logistic regression analysis was performed to identify independent risk factors for development of ED.
  
  
  RESULTS
  Mean age of the population was 67.3. No significant difference was observed between the two groups regarding the presece of DM, HT, smoking, BMI and laboratory measurements. ED rate was significantly higher in the PES group (70.6% vs 48.3%, p=0.002). Also, severe ED rate was higher in the PES group (p=0.002). PES was detected as an independent risk factors for the development of ED.
  
  
  CONCLUSIONS
  ED is a possible consequence of PES. ED rate and severity is found to be higher in the PES group and PES is detected as an independent risk factor for development of ED. Patients with PES should be informed about development of ED and further prospective trials with objective measurements of penile blood flow should be conducted to verify the erectile status and penile blood flow in PES patients.
authors.affiliation: Department of Ophtahalmology, Kudret Eye Hospital, Turkey.
authors.forename: Sabite Emine
authors.initials: SE
authors.lastname: Gokce
authors.affiliation: Department of Urology, Ankara University School of Medicine, Turkey.
authors.forename: Mehmet Ilker
authors.initials: MI
authors.lastname: Gokce
mesh_terms: D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D048909:Diabetes Complications; D004730:Endothelium, Vascular / Q000503:physiopathology; D004812:Epidemiologic Methods; D007172:Erectile Dysfunction / Q000209:etiology* / Q000503:physiopathology; D017889:Exfoliation Syndrome / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D010413:Penis / Q000098:blood supply; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood; D014652:Vascular Diseases / Q000150:complications* / Q000503:physiopathology
chemical_list: D014280:Triglycerides; D002784:Cholesterol