title: A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.
abstract: Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University. wangyanting2012@qq.com.
authors.forename: Yan-Ting
authors.initials: YT
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University. xueyr@nju.edu.cn.
authors.forename: Ya-Rong
authors.initials: YR
authors.lastname: Xue
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University. chliu@nju.edu.cn.
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Liu
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism / Q000494:pharmacology; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000378:metabolism / Q000494:pharmacology; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology; D001685:Biological Factors / Q000378:metabolism* / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D019015:Geologic Sediments / Q000382:microbiology*; D006801:Humans; D012623:Seawater / Q000382:microbiology*; D064210:Secondary Metabolism / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D001685:Biological Factors
keywords: anticancer; antifungal; antimicrobial; antiviral; bioactive compounds; deep-sea fungi