title: [Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease].
abstract: Cardiovascular disease is a severe threat to human health and life. Among many risk factors of cardiovascular disease, genetic or gene-based ones are drawing more and more attention in recent years. Accumulated evidence has demonstrated that the loss or mutation of ataxia telangiectasia mutated (ATM) gene can result in DNA damage repair dysfunctions, telomere shortening, decreased antioxidant capacity, insulin resistance, increased lipid levels, etc., and thus can promote the occurrence of cardiovascular risk factors, such as aging, atherosclerosis and metabolic syndrome. In this review, we discusses the possible mechanisms between ATM gene and cardiovascular risk factors, which could be helpful to the related research and clinical application.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ding
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: Jirong
authors.initials: J
authors.lastname: Yue
authors.forename: Hengyi
authors.initials: H
authors.lastname: Xiao
authors.forename: Birong
authors.initials: B
authors.lastname: Dong
mesh_terms: D000375:Aging; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D009154:Mutation; D012307:Risk Factors
chemical_list: D064007:Ataxia Telangiectasia Mutated Proteins