title: TWEAKing for a fight with GVHD.
abstract: In this issue of Blood, Chopra et al provide convincing evidence that tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) ligand acting through its receptor, fibroblast growth factor-inducible 14 (Fn14), is crucial to the intestinal apoptosis seen in graft-versus-host disease (GVHD) and associated mortality.
authors.affiliation: UNIVERSITY OF LIVERPOOL.
authors.forename: David J
authors.identifier: http://orcid.org/0000-0002-2879-0935
authors.initials: DJ
authors.lastname: MacEwan
mesh_terms: D000818:Animals; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D017209:Apoptosis; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D018124:Receptors, Tumor Necrosis Factor / Q000037:antagonists & inhibitors*; D000079424:Tumor Necrosis Factor Inhibitors
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D018124:Receptors, Tumor Necrosis Factor; D000079424:Tumor Necrosis Factor Inhibitors