title: Science to Practice: The Changing Face of Local Tumor Therapies-Do We Have to Think Systemically When Treating Cancer Locally?
abstract: In this issue, Rozenblum et al ( 1 ) were able to demonstrate that radiofrequency (RF) ablation-induced liver regeneration promotes "off-target" tumorigenesis in a MDR2 knock-out mouse model of hepatocellular carcinoma (HCC) in the setting of chronic liver inflammation. In addition, the authors demonstrated that blocking liver regeneration with a c-met inhibitor might attenuate or eliminate potential tumorigenic effects. These results provide the rationale for combined therapeutic approaches of RF ablation followed by a systemic application of immunomodulatory drugs.
authors.affiliation: Department of Diagnostic and Interventional Radiology Charité Universitätsmedizin Berlin Berlin, Germany.|Department of Diagnostic Radiology and Imaging Sciences Yale University School of Medicine 421 Temple St New Haven, CT 06520-8224.
authors.forename: Julius
authors.initials: J
authors.lastname: Chapiro
authors.affiliation: Department of Diagnostic and Interventional Radiology Charité Universitätsmedizin Berlin Berlin, Germany.|Department of Diagnostic Radiology and Imaging Sciences Yale University School of Medicine 421 Temple St New Haven, CT 06520-8224.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Geschwind
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects*; D000818:Animals; D063646:Carcinogenesis; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000601:surgery*; D004598:Electrosurgery / Q000009:adverse effects*; D006498:Hepatectomy / Q000379:methods*; D008113:Liver Neoplasms / Q000209:etiology* / Q000601:surgery*