title: Mobilisation of haemopoietic stem cells in teriparatide-treated patients.
abstract: Parathyroid hormone (PTH) is the predominant regulator of calcium/phosphate homeostasis in the human body. Beside this classical function, preclinical and clinical studies indicated a relevant role for PTH in mobilisation of bone marrow-derived cells into peripheral blood. In addition, recombinant PTH (teriparatide) was recently approved for the treatment of severe osteoporosis. Therefore, it was the aim of the present study to investigate the dynamics of haemopoietic stem cells and corresponding in peripheral blood of 13 patients with osteoporosis during treatment with teriparatide. We were able to show that administration of teriparatide is sufficient to mobilise haemopoietic stem cells into the bloodstream accompanied by an alteration of mobilising cytokines. In conclusion, teriparatide might be a useful tool in the context of stem cell mobilisation.
authors.affiliation: Medical Department I, Campus Innenstadt and Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Grabmaier
authors.affiliation: Medical Department I, Campus Innenstadt and Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: B C
authors.initials: BC
authors.lastname: Huber
authors.affiliation: Department of Internal Medicine III (Cardiology & Angiology), Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: W-M
authors.initials: WM
authors.lastname: Franz
authors.affiliation: Medical Department II, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Koch
authors.affiliation: Medical Department I, Campus Innenstadt and Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Brunner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy*; D011446:Prospective Studies; D019379:Teriparatide / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D019379:Teriparatide
keywords: haemopoietic stem cell; osteoporosis; teriparatide