title: [Analysis of Musculoskeletal Systems and Their Diseases. Gene regulatory network in development and maintenance of skeletal muscle cells].
abstract: In this section, we describe about key upstream factors to lead to the activation, differentiation of skeletal muscle cells in the mouse and chick models, such as Pax3/Pax7 genes. They are involved in gene regulatory networks at various sites of skeletal muscle formation. And microRNAs intervene with emerging evidences for novel roles to regulate key factors in myogenesis. We discuss new myogenic insights into mechanisms underlying the transcriptional activity of these factors.
authors.affiliation: Kyoto Prefectural University of Medicine, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Sato
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takeda
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D053263:Gene Regulatory Networks; D035683:MicroRNAs / Q000235:genetics; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors