title: Early Diet and Later Cancer Risk: Prospective Associations of Dietary Patterns During Critical Periods of Childhood with the GH-IGF Axis, Insulin Resistance and Body Fatness in Younger Adulthood.
abstract: Early life, adiposity rebound, and puberty represent critical growth periods when food choices could have long-term relevance for cancer risk. We aimed to relate dietary patterns during these periods to the growth hormone-insulin-like-growth-factor (GH-IGF) axis, insulin resistance, and body fatness in adulthood. Data from the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study participants with outcome data at 18-37 years, and ≥2 dietary records during early life (1-2 yr; n = 128), adiposity rebound (4-6 years, n = 179), or puberty (girls 9-14, boys 10-15 yr; n = 213) were used. Dietary patterns at these ages were derived by 1) reduced rank regression (RRR) to explain variation in adult IGF-I, IGF-binding protein-3 (IGFBP-3), homoeostasis model assessment for insulin resistance (HOMA-IR) and fat-mass index; 2) principal component analysis (PCA). Regarding RRR, the patterns "cake/canned fruit/cheese & eggs" (early life), "sweets & dairy" (adiposity rebound) and "high-fat foods" (pubertal boys) were independently associated with higher adult HOMA-IR. Furthermore, the patterns "favorable carbohydrate sources" (early life), "snack & convenience foods" (adiposity rebound), and "traditional & convenience carbohydrates" (pubertal boys) were related to adult IGFBP-3 (P trend < 0.01). PCA identified "healthy" patterns for all periods, but none was associated with the outcomes (P trend > 0.1). In conclusion, dietary patterns during sensitive growth periods may be of long-term relevance for adult insulin resistance and IGFBP-3.
authors.affiliation: a Department of Nutritional , Food and Consumer Sciences, Fulda University of Applied Sciences , Fulda , Germany.
authors.forename: Anke L B
authors.initials: AL
authors.lastname: Günther
authors.forename: Matthias B
authors.initials: MB
authors.lastname: Schulze
authors.forename: Anja
authors.initials: A
authors.lastname: Kroke
authors.forename: Katharina
authors.initials: K
authors.lastname: Diethelm
authors.forename: Gesa
authors.initials: G
authors.lastname: Joslowski
authors.forename: Danika
authors.initials: D
authors.lastname: Krupp
authors.forename: Stefan
authors.initials: S
authors.lastname: Wudy
authors.forename: Anette E
authors.initials: AE
authors.lastname: Buyken
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D000293:Adolescent; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D002675:Child, Preschool; D004032:Diet; D015930:Diet Records; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007223:Infant; D007333:Insulin Resistance; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D009369:Neoplasms / Q000378:metabolism*; D025341:Principal Component Analysis; D011446:Prospective Studies; D011627:Puberty / Q000378:metabolism; D055815:Young Adult
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I