title: Persistent viremia and urine shedding of tick-borne encephalitis virus in an infected immunosuppressed patient from a new epidemic cluster in North-Eastern Italy.
abstract: A persistent tick-borne encephalitis virus infection in an immune-suppressed patient is presented. Such an unusual clinical case offers the unique chance of detecting persistent viremia associated to the erythrocyte fraction and shedding of the virus in the urine for more than six weeks. The infection occurred in a new area of the Friuli Venezia-Giulia region (North Eastern Italy) where two additional cases are also being reported.
authors.affiliation: Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Caracciolo
authors.affiliation: Infectious Diseases Clinic, Santa Maria Misericordia University Hospital, Udine, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bassetti
authors.affiliation: Hematology Unit, Department of Oncology, University Hospital, Trieste, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Paladini
authors.affiliation: Infectious Diseases Unit, University Hospital, Trieste, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Luzzati
authors.affiliation: Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Santon
authors.affiliation: Infectious Diseases Clinic, Santa Maria Misericordia University Hospital, Udine, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Merelli
authors.affiliation: Hematology Unit, Department of Oncology, University Hospital, Trieste, Italy.
authors.forename: Giovanni De
authors.initials: GD
authors.lastname: Sabbata
authors.affiliation: Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
authors.forename: Tea
authors.initials: T
authors.lastname: Carletti
authors.affiliation: Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Marcello
authors.affiliation: Department of Medical, Surgical and Health Sciences, University of Trieste, Italy; Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy. Electronic address: pdagaro@units.it.
authors.forename: Pierlanfranco
authors.initials: P
authors.lastname: D'Agaro
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000276:immunology; D004669:Encephalitis Viruses, Tick-Borne / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D004675:Encephalitis, Tick-Borne / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D058872:Epidemics; D006801:Humans; D016867:Immunocompromised Host; D007558:Italy / Q000453:epidemiology; D008297:Male; D060888:Real-Time Polymerase Chain Reaction; D014556:Urine / Q000821:virology*; D014766:Viremia / Q000821:virology*; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral; D000970:Antineoplastic Agents
keywords: Friuli-Venezia Giulia region; Immuno-compromized host; Italy; Persistent infection; Real-time PCR; Sequencing; TBEV; Tick-borne encephalitis; Trieste; Virus isolation