title: Pleiotropic effects of HDL subfractions and HDL-associated enzymes on protection against coronary artery disease.
abstract: OBJECTIVE
  High-density lipoprotein cholesterol (HDL-C) levels are inversely related to the risk of coronary artery disease (CAD). Alterations in HDL-C subclass distribution and HDL-associated enzyme activities may be more important than total HDL levels for the progression of CAD. We intended to investigate the relationship of HDL-C subclass distribution and HDL-associated enzyme activities with CAD.
  
  
  RESULTS
  Our study included 101 patients with stable coronary artery disease, and 64 healthy subjects. Serum levels of HDL lipoprotein-associated-phospholipase A2 (HDL-LpPLA2), paraoxonase 1 (PON1), and HDL subfraction distribution were measured. We found increased small HDL (sHDL) subfractions in patients with one-vessel disease (P < 0.001). We also found a reverse correlation between total HDL-C levels and affected vessel number (P < 0.05). Plasma HDL-Lp PLA2 enzyme level was higher in each vessel disease category compared to the control group (P < 0.001). However, PON1 enzyme activity in patients with CAD was not statically significant. Plasma sHDL, HDL-Lp PLA2 enzyme and Lp(a) were significantly different between subjects with CAD and control participants.
  
  
  CONCLUSIONS
  We demonstrated decreased sHDL particles and a lower cardioprotective HDL-LpPLA, enzyme activity in all patient subgroups compared to controls. Measurement of total HDL-C level only may not be sufficient to predict CAD risk.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bostan
authors.forename: Hüseyin Avni
authors.initials: HA
authors.lastname: Uydu
authors.forename: Sermet
authors.initials: S
authors.lastname: Yildirmis
authors.forename: Meltem
authors.initials: M
authors.lastname: Malkoç
authors.forename: Mehtap
authors.initials: M
authors.lastname: Atak
authors.forename: Adem
authors.initials: A
authors.lastname: Demir
authors.forename: Adnan
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Uğurlu
authors.forename: Zakir
authors.initials: Z
authors.lastname: Karadağ
authors.forename: Hakan
authors.initials: H
authors.lastname: Duman
authors.forename: Omer
authors.initials: O
authors.lastname: Satiroğlu
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000201:enzymology* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D008076:Cholesterol, HDL; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D043303:Aryldialkylphosphatase