title: Silica shelled and block copolymer encapsulated red-emissive AIE nanoparticles with 50% quantum yield for two-photon excited vascular imaging.
abstract: A polymer and silica co-protection strategy has been developed to encapsulate organic fluorogens with aggregation-induced emission and charge transfer characteristics into small nanoparticles (NPs). The co-pretected NPs show bright red fluorescence (50% quantum yield) with a large two-photon action cross-section (450 GM at 840 nm), which have been sucessfully used for two-photon fluorescence imaging of vasculature of the mouse tibial muscle.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585. cheliub@nus.edu.sg.
authors.forename: Junlong
authors.initials: J
authors.lastname: Geng
authors.forename: Chi Ching
authors.initials: CC
authors.lastname: Goh
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Rongrong
authors.initials: R
authors.lastname: Liu
authors.forename: Nikodem
authors.initials: N
authors.lastname: Tomczak
authors.forename: Lai Guan
authors.initials: LG
authors.lastname: Ng
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000473:pathology*; D007783:Lactones / Q000737:chemistry; D051379:Mice; D018482:Muscle, Skeletal / Q000473:pathology; D053758:Nanoparticles / Q000737:chemistry*; D061848:Optical Imaging; D017785:Photons; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D007783:Lactones; D011108:Polymers; C521904:poly(ethylene glycol)-block-poly(epsilon-caprolactone); D011092:Polyethylene Glycols; D012822:Silicon Dioxide