title: Possible relationship between the resistin gene C-420G polymorphism and colorectal cancer in a Turkish population.
abstract: OBJECTIVE
  In recent years, with improvements in genotyping, a possible relationship between obesity-related gene polymorphisms and colorectal cancer (CRC) has been studied. The promoter region C-420G of the resistin gene is believed to have an important role in the development of malignancy. We prospectively evaluated the possible effect of the resistin C-420G polymorphism on the risk and prognosis of CRC.
  
  
  METHODS
  One hundred twenty-three patients with CRC and 79 healthy individuals were included in the study. Blood samples were genotyped, and the relationship between the resistin C-420G polymorphism and demographic characteristics and tumor features was evaluated.
  
  
  RESULTS
  No statistically significant difference was found in genotype distribution between the patient and control groups and among patients in the means of gender, biochemical findings, and tumor characteristics (p>0.05).
  
  
  CONCLUSIONS
  The relationship between the C-420G polymorphism and various diseases has been evaluated in many studies to date. With the increased importance of obesity in etiopathogenesis, studies have focused on CRC. According to our results, the GG genotype may be associated with a decreased CRC risk. Our study is important because to our knowledge, it is the first one to be conducted in a Turkish population to date, but we believe that more patients and controls are needed to obtain statistically significant results.
authors.affiliation: Department of General Surgery Clinic, İstanbul Training and Research Hospital, İstanbul, Turkey. soykanarikan@yahoo.com.
authors.forename: Yiğit
authors.initials: Y
authors.lastname: Düzköylü
authors.forename: Soykan
authors.initials: S
authors.lastname: Arıkan
authors.forename: Saime
authors.initials: S
authors.lastname: Turan
authors.forename: İlhan
authors.initials: İ
authors.lastname: Yaylım
authors.forename: Mehmet Baki
authors.initials: MB
authors.lastname: Doğan
authors.forename: Serkan
authors.initials: S
authors.lastname: Sarı
authors.forename: Feyzullah
authors.initials: F
authors.lastname: Ersöz
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Zeybek
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Tımırcı Kahraman
authors.forename: Burcu
authors.initials: B
authors.lastname: Çelikel
authors.forename: Simge
authors.initials: S
authors.lastname: Erdem
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D052243:Resistin / Q000235:genetics* / Q000378:metabolism; D014421:Turkey / Q000453:epidemiology
chemical_list: D004273:DNA, Neoplasm; C499624:RETN protein, human; D052243:Resistin