title: Iron-catalyzed direct α-arylation of ethers with azoles.
abstract: The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient C2-alkylation of a variety of (benzo)azoles constituting straightforward access to heterocycles of utmost medicinal significance and highlighting the convenient use of feedstock substrates and iron catalysts. A preliminary mechanism supported by DFT calculations is discussed as well.
authors.affiliation: Department of Organic Chemistry I, University of the Basque Country (UPV/EHU), Joxe Mari Korta R&D Center, Avda. Tolosa 72, 20018 Donostia-San Sebastión, Spain. arkaitz.correa@ehu.es.
authors.forename: Arkaitz
authors.initials: A
authors.lastname: Correa
authors.forename: Béla
authors.initials: B
authors.lastname: Fiser
authors.forename: Enrique
authors.initials: E
authors.lastname: Gómez-Bengoa