title: Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis.
abstract: The global variations in the gene expression pattern of drug treated (½X) and laboratory evolved drug-resistant strains (2XR and 4XR) of Mycobacterium smegmatis were obtained and compared with the M. smegmatis mc(2) 155 (WT) strain. The genes exhibiting two-fold change and p-value <0.05 under the treated conditions have been considered as differentially expressed genes (DEGs). Overall, the numbers of DEGs observed are 1529 in ½X (596-up, 933-down), 1381 (899-up, 482-down) in 2XR and 716 in 4XR (267-up, 449-down) conditions. The data is publicly available through the GEO database with accession number GSE64132.
authors.affiliation: Department of Biochemistry, IISc, Bangalore 560012, India ; Supercomputer Education and Research Centre, IISc, Bangalore 560012, India.
authors.forename: Jyothi
authors.initials: J
authors.lastname: Padiadpu
authors.affiliation: Department of Biochemistry, IISc, Bangalore 560012, India ; Molecular Biophysics Unit, IISc, Bangalore 560012, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Baloni
authors.affiliation: Department of Biochemistry, IISc, Bangalore 560012, India.
authors.forename: Nagasuma
authors.initials: N
authors.lastname: Chandra