title: AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein.
abstract: In this paper, we propose an AlGaN/GaN high electron mobility transistor (HEMT)-based biosensor for the detection of C-reactive protein (CRP) using a null-balancing circuit. A null-balancing circuit was used to measure the output voltage of the sensor directly. The output voltage of the proposed biosensor was varied by antigen-antibody interactions on the gate surface due to CRP charges. The AlGaN/GaN HFET-based biosensor with null-balancing circuit applied shows that CRP can be detected in a wide range of concentrations, varying from 10 ng/mL to 1000 ng/mL. X-ray photoelectron spectroscopy was carried out to verify the immobilization of self-assembled monolayer with Au on the gated region.
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. heeholee@ee.knu.ac.kr.
authors.forename: Hee Ho
authors.initials: HH
authors.lastname: Lee
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. mhbae@ee.knu.ac.kr.
authors.forename: Myunghan
authors.initials: M
authors.lastname: Bae
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. shjo@ee.knu.ac.kr.
authors.forename: Sung-Hyun
authors.initials: SH
authors.lastname: Jo
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. jkshin@ee.knu.ac.kr.
authors.forename: Jang-Kyoo
authors.initials: JK
authors.lastname: Shin
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. dhson@ee.knu.ac.kr.
authors.forename: Dong Hyeok
authors.initials: DH
authors.lastname: Son
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. chwon@ee.knu.ac.kr.
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Won
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. hmjeong@ee.knu.ac.kr.
authors.forename: Hyun-Min
authors.initials: HM
authors.lastname: Jeong
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. jlee@ee.knu.ac.kr.
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, Korea. swkang@knu.ac.kr.
authors.forename: Shin-Won
authors.initials: SW
authors.lastname: Kang
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation*; D002097:C-Reactive Protein / Q000032:analysis*; D004560:Electricity; D004583:Electrons; D005708:Gallium / Q000737:chemistry*; D006801:Humans; D056951:Photoelectron Spectroscopy; D014173:Transistors, Electronic
chemical_list: D017607:Aluminum Compounds; C513700:aluminum gallium nitride; C473348:gallium nitride; D002097:C-Reactive Protein; D005708:Gallium
keywords: AlGaN/GaN; CRP; HEMT; biosensor; null-balancing circuit