title: Short term results of cementless total hip arthroplasty in sicklers.
abstract: BACKGROUND
  Sickle cell (SC) disease leading to endarteritis induces skeletal changes in the form of osteitis, sclerosis of femoral canal and osteonecrosis of the femoral head. All these make total hip arthroplasty (THA) difficult and prolonged. There is increased risk of infection, SC crisis and increased complication rate. Our paper aims to highlight preoperative, intraoperative and postoperative hurdles encountered in performing THA in sicklers and the short term outcome using cementless implants.
  
  
  METHODS
  Thirty-nine patients with SC disease, who had osteonecrosis of the femoral head, were operated between 2007 and 2011. The mean age of patients was 22 years (range 13-49 years). There were twenty eight females and 11 males. Bilateral cementless total hip replacement (THR) was performed in 11 patients (22 hips) and in the rest unilateral (28 hips). Preoperative and postoperative modified Harris hip score was evaluated. The average followup was 3.8 years (range 2-6 years).
  
  
  RESULTS
  The average operating time was 96 min (range 88-148 min). The average blood loss was 880 ml (range 650-1200 ml). The average intraoperative blood transfused was 2.3 units (range 2-5 units). All patients showed an improvement in Harris hip score from 42 points preoperatively to 92 points at latest followup. Intraoperatively, one patient had a periprosthetic fracture. Six patients developed acute SC crisis and were managed in intensive care unit. Three patients developed wound hematoma. Three patients developed limb length discrepancy less than 1 cm. None had early or late dislocations, infection, heterotopic ossification, sciatic nerve palsy and aseptic loosening.
  
  
  CONCLUSIONS
  THA in sicklers involves considerable challenge for the orthopedic surgeon. Management requires a multidisciplinary approach involving the anesthetist, hematologist and the orthopedic surgeon. Contrary to previous reports, THA in sicklers now has a predictable outcome especially with the use of cementless implants.
authors.affiliation: Department of Orthopaedics, Joint Reconstruction, Sports Injury and Spine, BLK Super Speciality Hospital, New Delhi, India.
authors.forename: Yash
authors.initials: Y
authors.lastname: Gulati
authors.affiliation: Department of Orthopaedics, Joint Reconstruction, Sports Injury and Spine, BLK Super Speciality Hospital, New Delhi, India.
authors.forename: Mrinal
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Department of Orthopaedics, Joint Reconstruction, Sports Injury and Spine, BLK Super Speciality Hospital, New Delhi, India.
authors.forename: Bhupendra
authors.initials: B
authors.lastname: Bharti
authors.affiliation: Department of Orthopaedics, Joint Reconstruction, Sports Injury and Spine, BLK Super Speciality Hospital, New Delhi, India.
authors.forename: Vibhu
authors.initials: V
authors.lastname: Bahl
authors.affiliation: Department of Orthopaedics, Joint Reconstruction, Sports Injury and Spine, BLK Super Speciality Hospital, New Delhi, India.
authors.forename: Ishwar
authors.initials: I
authors.lastname: Bohra
authors.affiliation: Department of Orthopaedics, Joint Reconstruction, Sports Injury and Spine, BLK Super Speciality Hospital, New Delhi, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Goswani
keywords: Arthroplasty; Cementless implants; avascular necrosis; avascular necrosis of bone; femoral head; haemoglobin disease; hip; osteonecrosis; replacement; sickle cell anemia; sickle cell disease; total hip arthroplasty