title: Ocular Graft-Versus-Host Disease: A Review.
abstract: Hematopoietic stem cell transplantation is important in the management of several lymphoproliferative and bone marrow disorders. Graft-versus-host disease (GVHD) involves inflammatory manifestations that arise after transplant and can affect many organs. Ocular manifestations of GVHD are common, and eye care providers must understand this disease entity. The ocular surface is most commonly involved, but GVHD can affect all parts of the eye. Ocular GVHD can be relapsing and remitting, can decrease quality of life, and can be challenging to diagnose and adequately treat. The diagnostic criteria for and grading of ocular GVHD continue to evolve. This review aims to summarize current definitions, clinical findings, diagnostic criteria, and management of ocular GVHD. The care of patients with ocular GVHD requires a multidisciplinary approach.
authors.affiliation: Department of Ophthalmology (S.C.B., H.R., C.B.N., M.M.S.), Mayo Clinic, Rochester, MN; and Department of Ophthalmology (J.F.S.), Mayo Clinic, Scottsdale, AZ.
authors.forename: Saranya C
authors.initials: SC
authors.lastname: Balasubramaniam
authors.forename: Harish
authors.initials: H
authors.lastname: Raja
authors.forename: Cherie B
authors.initials: CB
authors.lastname: Nau
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Shen
authors.forename: Muriel M
authors.initials: MM
authors.lastname: Schornack
mesh_terms: D003229:Conjunctival Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006086:Graft vs Host Disease / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D011788:Quality of Life