title: Immunophenotype of Spontaneous Hematolymphoid Tumors Occurring in Young and Aging Female CD-1 Mice. [Corrected].
abstract: A few reports indicated the incidence of hematolymphoid neoplasms in old CD-1 mice, but the cellular lineage of CD-1 mouse neoplasms has not been published. In this study, immunohistochemistry (IHC) was used to characterize the cellular lineage of spontaneous hematolymphoid neoplasms arising in 24 young female CD-1 mice used as health-monitoring sentinels and 32 aging female CD-1 mice used as controls in 80-week carcinogenesis studies. Lymphoblastic lymphomas of T-cell and B-cell lineage were common in mice aged 12 months or less, whereas a wide range of non-lymphoblastic B-cell lymphomas and lymphoblastic B-cell lymphomas were common in mice >12-mo-old. Renal hyaline droplets positive for lysozyme were observed in aged mice with a histiocytic-associated large B-cell lymphoma (HA-BCL) and a myeloid leukemia. Endogenous ecotropic mouse leukemia virus (MuLV) genes have been recovered from CD-1 mice, but MuLV protein expression has not been previously demonstrated. We reported for the first time the expression of a MuLV protein p30 by IHC in lymphomas and some normal tissues of both young and aging CD-1 mice. This report should help to differentiate spontaneous lymphomas and leukemias in CD-1 mice from those induced by chemicals and other methods.
authors.affiliation: St. Jude Children's Research Hospital, Memphis, Tennessee, USA jerold.rehg@stjude.org veterinarypathology@gmail.com.
authors.forename: Jerold E
authors.initials: JE
authors.lastname: Rehg
authors.affiliation: St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Rahija
authors.affiliation: St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: Dorothy
authors.initials: D
authors.lastname: Bush
authors.affiliation: Charles River Edinburgh, Tranent, Scotland, UK.
authors.forename: Alys
authors.initials: A
authors.lastname: Bradley
authors.affiliation: Global Vet Pathology, Montgomery Village, Maryland, USA.
authors.forename: Jerrold M
authors.initials: JM
authors.lastname: Ward
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D019337:Hematologic Neoplasms / Q000473:pathology* / Q000821:virology; D007150:Immunohistochemistry; D016130:Immunophenotyping; D009052:Leukemia Virus, Murine; D051379:Mice; D012192:Retroviridae Infections / Q000150:complications; D014412:Tumor Virus Infections / Q000473:pathology
keywords: CD-1 mice; female; hematolymphoid neoplasms; immunohistochemistry; leukemia; lymphoma; retrovirus