title: Clinical Effect of Shenfu Injection in Patients with Septic Shock: A Meta-Analysis and Systematic Review.
abstract: Purpose. To conduct a meta-analysis evaluating the efficacy of Shenfu injection for treating patients with septic shock when compared with conventional therapy. Methods. Eight databases including Pubmed, EMBASE, Cochrane Library, ISI Web of Science, CNKI, Wanfang, VIP, and CBM were searched up to October 2014. Randomized controlled trials assessing the efficacy of Shenfu injection were identified. Mean arterial pressure, heart rate, lactate, and mortality were included as outcome measurements. Results. We analyzed data from 12 randomized controlled trials involving 904 participants. Compared with conventional therapy, Shenfu injection could further increase the mean arterial pressure at 1 hour (SMD 0.38; 95% CI, 0.01-0.74) and 6 hours (SMD 0.82; 95% CI, 0.03-1.61). Shenfu injection could further normalize heart rate at 6 hours (SMD -0.90; 95% CI, -1.47-0.33) and clear serum lactate at 6 hours (SMD -0.51; 95% CI, -0.70-0.32) and 24 hours (SMD, 0.52; 95% CI, -0.77-0.26). As the endpoint of mortality was not unified, it was not meta-analyzed. Conclusions. Based on the findings in present review, Shenfu injection is more effective than conventional therapy in increasing mean arterial pressure, normalizing heart rate, clearing serum lactate, and reducing mortality. These results should be confirmed in higher level clinical trials in the future.
authors.affiliation: Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Zijun
authors.initials: Z
authors.lastname: Mou
authors.affiliation: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Zhengtao
authors.initials: Z
authors.lastname: Lv
authors.affiliation: Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Yu