title: An integrated mathematical model of the cardiovascular and respiratory systems.
abstract: This study presents a lumped model for the human cardiorespiratory system. Specifically, we incorporate a sophisticated gas dissociation and transport system to a fully integrated cardiovascular and pulmonary model. The model provides physiologically consistent predictions in terms of hemodynamic variables such as pressure, flow rate, gas partial pressures, and pH. We perform numerical simulations to evaluate the behavior of the partial pressures of oxygen and carbon dioxide in different vascular and pulmonary compartments. For this, we design the rest condition with low oxygen requirements and carbon dioxide production and exercise conditions with high oxygen demand and carbon dioxide production. Furthermore, model sensitivity to more relevant model parameters is studied. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Laboratório Nacional de Computação Centífica, Av. Getúlio Vargas, 333, Quitandinha, Petrópolis, RJ, 25651-075, Brazil.|Instituto Nacional de Ciência e Tecnologia em Medicina Assistida por Computação Centífica, Petrópolis, Brazil.
authors.forename: Paulo Roberto
authors.initials: PR
authors.lastname: Trenhago
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Biologia, Universidade Federal Rural do Rio de Janeiro, BR-465 Km 07, Seropédica, RJ, 23890-000, Brazil.|Instituto Nacional de Ciência e Tecnologia em Medicina Assistida por Computação Centífica, Petrópolis, Brazil.
authors.forename: Luciano Gonçalves
authors.initials: LG
authors.lastname: Fernandes
authors.affiliation: Laboratório Nacional de Computação Centífica, Av. Getúlio Vargas, 333, Quitandinha, Petrópolis, RJ, 25651-075, Brazil.|Instituto Nacional de Ciência e Tecnologia em Medicina Assistida por Computação Centífica, Petrópolis, Brazil.
authors.forename: Lucas Omar
authors.initials: LO
authors.lastname: Müller
authors.affiliation: Laboratório Nacional de Computação Centífica, Av. Getúlio Vargas, 333, Quitandinha, Petrópolis, RJ, 25651-075, Brazil.|Instituto Nacional de Ciência e Tecnologia em Medicina Assistida por Computação Centífica, Petrópolis, Brazil.
authors.forename: Pablo Javier
authors.initials: PJ
authors.lastname: Blanco
authors.affiliation: Laboratório Nacional de Computação Centífica, Av. Getúlio Vargas, 333, Quitandinha, Petrópolis, RJ, 25651-075, Brazil.|Instituto Nacional de Ciência e Tecnologia em Medicina Assistida por Computação Centífica, Petrópolis, Brazil.
authors.forename: Raúl Antonino
authors.initials: RA
authors.lastname: Feijóo
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D015444:Exercise / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D018511:Systems Integration
keywords: blood gas transport; cardiorespiratory system; exercise; gas dissociation