title: Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients.
abstract: The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIV- (n = 537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p < 0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Division of Hematology, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Jou
authors.affiliation: Division of Hematology, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Oleg
authors.initials: O
authors.lastname: Gligich
authors.affiliation: Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Alvita C Y
authors.initials: AC
authors.lastname: Chan
authors.affiliation: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Diwakar
authors.initials: D
authors.lastname: Mohan
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Uriel R
authors.initials: UR
authors.lastname: Felsen
authors.affiliation: Department of Hematology and Oncology, University Hospitals Case Medical Center, Cleveland, OH, USA.
authors.forename: Sabarish
authors.initials: S
authors.lastname: Ayyappan
authors.affiliation: Division of Hematology, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Henny H
authors.initials: HH
authors.lastname: Billett
authors.affiliation: Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Edwin P
authors.initials: EP
authors.lastname: Hui
authors.affiliation: Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Chan
authors.affiliation: Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Radha
authors.initials: R
authors.lastname: Raghupathy
mesh_terms: D000465:Algorithms; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D019337:Hematologic Neoplasms / Q000150:complications / Q000276:immunology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D016017:Odds Ratio; D015995:Prevalence; D012044:Regression Analysis; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome
keywords: HIV; hematological malignancy; monoclonal proteins; oligoclonal proteins; paraproteins