title: Morphometric variability of neuroimaging features in children with agenesis of the corpus callosum.
abstract: BACKGROUND
  Agenesis of the corpus callosum (ACC) is a developmental brain malformation associated with a wide spectrum of structural brain abnormalities and genetic loci. To characterize the diverse callosal morphologies and malformations of brain development associated with ACC, we report on the neuroimaging findings of 201 individuals diagnosed with corpus callosal abnormalities.
  
  
  METHODS
  We searched through medical records of individuals seen at New York Presbyterian Hospital between 2002 and 2013 and thought to have ACC. We confirmed 201 individuals meeting criteria and used magnetic resonance imaging to characterize morphological variants of the corpus callosum and associated brain malformations.
  
  
  RESULTS
  The majority of individuals displayed hypoplasia or dysplasia of the corpus callosum (N = 160, 80 %). Forty-one (20 %) displayed complete agenesis of the corpus callosum with other abnormalities, while only 18 (9 %) displayed complete agenesis without associated brain abnormalities. White matter abnormalities were more frequent in hypoplasia or dysplasia group than complete agenesis (28.2 % vs 9.8 %, p < 0.05). In contrast, hippocampal abnormalities, colpocephaly, and Probst bundles were significantly more frequent in complete agenesis compared to hypoplasia or dysplasia group.
  
  
  CONCLUSIONS
  Collectively, our results underscore the broad diversity of morphological variants of the corpus callosum and associated brain abnormalities in individuals with ACC.
authors.affiliation: Department of Neurology, Columbia University Medical Center, New York Presbyterian Hospital, 710 West 168th St, New York, NY, 10032, USA.
authors.forename: Jason Bennett
authors.initials: JB
authors.lastname: Neal
authors.affiliation: Department of Neuroradiology, Columbia University Medical Center, New York Presbyterian Hospital, 622 West 168th St, New York, NY, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Filippi
authors.affiliation: Department of Neurology, Columbia University Medical Center, New York Presbyterian Hospital, 710 West 168th St, New York, NY, 10032, USA. rpm2@columbia.edu.|Gertrude H. Sergievsky Center, Columbia University, New York, USA. rpm2@columbia.edu.
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D061085:Agenesis of Corpus Callosum / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020547:Lateral Ventricles / Q000002:abnormalities* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D012189:Retrospective Studies; D066127:White Matter / Q000473:pathology*; D055815:Young Adult