title: Imaging Nigrostriatal Dopaminergic Deficit in Holmes Tremor with 18F-PR04.MZ-PET/CT.
abstract: Holmes tremor is an infrequent clinical syndrome characterized by unilateral rest, postural, and action tremor often secondary to a brain lesion. We herein report an interesting case of Holmes tremor studied with PET and F-PR04.MZ, a new high-affinity radioligand for dopamine transporters, currently under investigation at our center. F-PR04.MZ-PET can be useful to study the integrity of the nigrostriatal dopaminergic system to improve diagnosis and therapeutic outcome in patients with Holmes tremor and Parkinson disease.
authors.affiliation: From the *Department of Neurology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; †Department of Neurology, Hospital Sotero del Río, Santiago, Chile; ‡Department of Neurology, Universidad de Santiago de Chile, Santiago, Chile; §Nuclear Medicine and PET/CT Center FALP, Santiago,Chile; ¶Department of Chemistry, University of Oslo, Oslo, Norway; and ∥Institute of Nuclear Chemistry, Johannes Gutenberg-University, Mainz, Germany.
authors.forename: Carlos
authors.initials: C
authors.lastname: Juri
authors.forename: Pedro
authors.initials: P
authors.lastname: Chana
authors.forename: Vasko
authors.initials: V
authors.lastname: Kramer
authors.forename: Rossana
authors.initials: R
authors.lastname: Pruzzo
authors.forename: Horacio
authors.initials: H
authors.lastname: Amaral
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Riss
authors.forename: Frank
authors.initials: F
authors.lastname: Rösch
mesh_terms: D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging; D008875:Middle Aged; D064847:Multimodal Imaging; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics*; D014057:Tomography, X-Ray Computed; D014202:Tremor / Q000000981:diagnostic imaging*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals