title: Late Nailfold Videocapillaroscopy Pattern Associated With Hand Calcinosis and Acro-Osteolysis in Systemic Sclerosis.
abstract: OBJECTIVE
  To determine whether calcinosis and acro-osteolysis are related to specific nailfold videocapillaroscopy (NVC) features in patients with systemic sclerosis (SSc; scleroderma).
  
  
  METHODS
  NVC and bilateral hand radiographs were systematically performed in 155 consecutively recruited patients with SSc during a 24-month period. Radiologic assessment of calcinosis and acro-osteolysis was performed blinded for the results on NVC features.
  
  
  RESULTS
  Patients with calcinosis (n = 29) or acro-osteolysis (n = 25) on radiographs were more likely to have the late pattern on NVC, defined by severe loss of capillaries and neoangiogenesis (P = 0.003 and P < 0.001, respectively). A reduced number of capillaries was significantly found in patients with calcinosis (mean ± SD 3.55 ± 1.76 versus 5.53 ± 2.32 capillaries per finger; P < 0.001) and acro-osteolysis (mean ± SD 2.88 ± 1.30 versus 5.60 ± 2.26 capillaries per finger; P < 0.001). In addition, neoangiogenesis was more frequently observed in patients with severe acro-osteolysis (P = 0.021). Multivariate logistic regression analysis confirmed the independent association between the late NVC pattern and calcinosis (odds ratio [OR] 3.04, 95% confidence interval [95% CI] 1.20-7.68) or acro-osteolysis (OR 4.57, 95% CI 1.66-12.55), together with history of and/or active digital ulcers.
  
  
  CONCLUSIONS
  Acro-osteolysis and calcinosis are independently associated with the late NVC pattern and particularly with severe capillary loss. These results strengthen the link between these radiographic lesions and digital destructive vasculopathy. Moreover, severe acro-osteolysis was more likely to occur with neoangiogenesis, which may suggest an attempt to compensate bone resorption. Further studies are now needed to better understand the physiopathology of calcinosis and acro-osteolysis and determine whether any agent may modify the course of these lesions by influencing vessel damages.
authors.affiliation: Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France.
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Morardet
authors.affiliation: Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Avouac
authors.affiliation: Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France.
authors.forename: Maya
authors.initials: M
authors.lastname: Sammour
authors.affiliation: Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Murray
authors.initials: M
authors.lastname: Baron
authors.affiliation: Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France.
authors.forename: André
authors.initials: A
authors.lastname: Kahan
authors.affiliation: Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Feydy
authors.affiliation: Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Allanore
mesh_terms: D030981:Acro-Osteolysis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D000368:Aged; D002114:Calcinosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002196:Capillaries / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D050276:Hand Bones / Q000000981:diagnostic imaging; D006801:Humans; D016015:Logistic Models; D008297:Male; D020678:Microscopic Angioscopy; D008875:Middle Aged; D015999:Multivariate Analysis; D009262:Nails / Q000098:blood supply*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011859:Radiography; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology