title: Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis.
abstract: Upregulation of the inflammatory cascade is a major element both in the progression of steatohepatitis to severe alcoholic hepatitis as well as in the progression of NASH to advanced NASH with fibrosis. The mechanisms underpinning these changes are only partially understood. Activation of the inflammatory cascade requires multiple stimuli and in this report, we discuss the role of inflammasomes that activate IL-1β as well as the sterile and pathogen-derived danger signals that results in inflammasome activation and inflammation in alcoholic and non-alcoholic steatohepatitis. The dynamics of inflammasome activation, the cell types involved and the trigger signals appear to be somewhat different between ASH and NASH. Further studies are needed to dissect the pathology-related differences between these two major forms of steatohepatitis. Clinical and therapeutic implications of inflammasome activation in steatohepatitis are also discussed.
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, LRB 215, 364, Plantation Street, 01605 Worcester, United States. Electronic address: gyongyi.szabo@umassmed.edu.
authors.forename: Gyongyi
authors.initials: G
authors.lastname: Szabo
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, LRB 215, 364, Plantation Street, 01605 Worcester, United States.
authors.forename: Arvin
authors.initials: A
authors.lastname: Iracheta-Vellve
mesh_terms: D000818:Animals; D018450:Disease Progression; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005234:Fatty Liver / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use; D053583:Interleukin-1beta / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D004791:Enzyme Inhibitors; D058847:Inflammasomes; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta