title: No Association Between Vitamin D Intake, VDR Polymorphisms, and Colorectal Cancer in a Population-Based Case-Control Study.
abstract: BACKGROUND
  Epidemiologic evidence indicates that greater intakes of vitamin D may decrease the risk of colorectal cancer. Variants in the vitamin D receptor (VDR) gene have the potential to modify associations between vitamin D intake and colorectal cancer.
  
  
  METHODS
  Associations between intakes of vitamin D and colorectal cancer were studied in a large case-control study conducted in central and northeastern Pennsylvania including 1,012 cases with histologically confirmed colorectal cancer and 1,080 population-based controls. Associations between 35 tagSNPs encompassing the VDR gene and risk for colorectal cancer as well as gene-diet associations were also assessed among a subset of the population (770 controls, 710 cases).
  
  
  RESULTS
  No significant trends were observed between vitamin D intake and colorectal cancer risk. After adjustment for multiple comparisons, none of the SNPs or haplotypes within the VDR gene were associated with colorectal cancer. There were also no interactions between dietary factors and variants in the entire VDR gene.
  
  
  CONCLUSIONS
  Overall, results from this study suggest that vitamin D intake and variants in the VDR gene have little effect on risk for colorectal cancer.
  
  
  CONCLUSIONS
  Increasing vitamin D intake from the diet may not result in decreasing the incidence of colorectal cancer.
authors.affiliation: Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington.
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Ashmore
authors.affiliation: Department of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania. Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania.
authors.forename: Carla J
authors.initials: CJ
authors.lastname: Gallagher
authors.affiliation: Northeast Regional Cancer Institute, Scranton, Pennsylvania. The Commonwealth Medical College, Scranton, Pennsylvania.
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Lesko
authors.affiliation: Department of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania.
authors.forename: Joshua E
authors.initials: JE
authors.lastname: Muscat
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, and Winship Cancer Institute, Emory University, Atlanta, Georgia.
authors.forename: Terryl J
authors.initials: TJ
authors.lastname: Hartman
authors.affiliation: Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington. phil.lazarus@wsu.edu.
authors.forename: Philip
authors.initials: P
authors.lastname: Lazarus
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010414:Pennsylvania / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D014807:Vitamin D / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D004273:DNA, Neoplasm; D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014815:Vitamins; D014807:Vitamin D