title: A pooled analysis of alcohol intake and colorectal cancer.
abstract: OBJECTIVE
  In order to provide an updated quantification of the association between alcohol intake and colorectal cancer, we conducted a meta-analysis of published observational studies.
  
  
  METHODS
  Two cohort and 22 case-control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published before July 2014. Data were extracted independently by two reviewers. Random effects meta-analyses, subgroup analyses, and meta regression were performed for modeling the dose-response relation.
  
  
  RESULTS
  The pooled relative risk (RR) for any alcohol intake compared with non/occasional drinking was 1.13 [95% confidence interval (CI), 1.09-1.17]. The RRs were 1.07 (95% CI, 1.02-1.13), 1.23 (95% CI, 1.15-1.32) and 1.37 (95% CI, 1.26-1.49) for light (≤12.5 g/day), moderate (12.6 to 49.9 g/day) and heavy drinking (≥50 g/day), respectively. The risks were consistent in the subgroup analyses of sex and tumor site.
  
  
  CONCLUSIONS
  This meta-analysis provides strong evidence for an association between alcohol intake and colorectal cancer risk.
authors.affiliation: Deaprtment of Surgery, Liaoning Cancer Hospital and Institute Shenyang, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Zhengzhou University Zhengzhou, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Duan
authors.affiliation: Institute of Public Health, University of California San Francisco, USA.
authors.forename: Helen
authors.initials: H
authors.lastname: Yang
authors.affiliation: Deaprtment of Surgery, Liaoning Cancer Hospital and Institute Shenyang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lin
keywords: Alcohol intake; colorectal neoplasms; meta-analysis