title: The Effect of Bariatric Surgery Type on Lipid Profile: An Age, Sex, Body Mass Index and Excess Weight Loss Matched Study.
abstract: BACKGROUND
  Bariatric surgery improves lipid profile. A still unanswered question is whether this improvement is merely weight-dependent or also results from factors inherent to specificities of the bariatric procedure. We aimed to study lipid profile 1 year after bariatric surgery and compare its changes between the different procedures in patients matched for initial weight and weight loss.
  
  
  METHODS
  We retrospectively analysed patients submitted to Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB) or sleeve gastrectomy (SG) between 2010 and 2013. Patients were matched for age (±5 years), sex, pre-surgery body mass index (BMI) (±2 Kg/m(2)) and excess weight loss (EWL) (±5%). Baseline and 1-year lipid profile, its variation and percentage of variation was compared between surgeries.
  
  
  RESULTS
  We analysed 229 patients: 72 pairs RYGB-AGB, 47 pairs RYGB-SG and 33 pairs AGB-SG. The median age was 41 (35-52) years and 11.8% were male. Pre-operative BMI was 44.0 ± 4.6 and 32.1 ± 4.4 Kg/m(2) at 1 year. EWL at 1 year was 64.2 ± 18.9%. There were no differences in baseline lipid profile between patients submitted to different types of bariatric surgery. At 1 year, high-density lipoprotein cholesterol (HDL) and triglycerides (TG) improved similarly with all surgeries. Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL) at 1 year decreased significantly more in patients submitted to RYGB than in weight-matched patients undergoing AGB or SG.
  
  
  CONCLUSIONS
  RYGB is the only bariatric surgery that reduces TC and LDL in age-, sex-, BMI- and EWL-matched patients. All three procedures improved TG and HDL similarly when the confounding effect of weight loss is eliminated.
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal. filipemrcunha@gmail.com.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal. filipemrcunha@gmail.com.
authors.forename: Filipe M
authors.initials: FM
authors.lastname: Cunha
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Oliveira
authors.affiliation: Serviço de Cirurgia Geral, Centro Hospitalar de São João, Porto, Portugal.
authors.forename: John
authors.initials: J
authors.lastname: Preto
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Saavedra
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Costa
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
authors.forename: Daniela
authors.initials: D
authors.lastname: Magalhães
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
authors.forename: Eva
authors.initials: E
authors.lastname: Lau
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
authors.forename: Rita
authors.initials: R
authors.lastname: Bettencourt-Silva
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
authors.forename: Paula
authors.initials: P
authors.lastname: Freitas
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Varela
authors.affiliation: Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.|Faculdade de Medicina da Universidade do Porto, Porto, Portugal.|Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
authors.forename: Davide
authors.initials: D
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D000367:Age Factors; D050110:Bariatric Surgery / Q000379:methods; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D012189:Retrospective Studies; D015431:Weight Loss / Q000502:physiology
chemical_list: D008076:Cholesterol, HDL; D008055:Lipids
keywords: Adjustable gastric banding; Bariatric surgery; Lipid profile; Matched study; Roux-en-Y gastric bypass; Sleeve gastrectomy