title: BODIPY: A Highly Versatile Platform for the Design of Bimodal Imaging Probes.
abstract: In molecular imaging, multimodal imaging agents can provide complementary information, for improving the accuracy of disease diagnosis or enhancing patient management. In particular, optical/nuclear imaging may find important preclinical and clinical applications. To simplify the preparation of dual-labeled imaging agents, we prepared versatile monomolecular multimodal imaging probe (MOMIP) platforms containing both a fluorescent dye (BODIPY) and a metal chelator (polyazamacrocycle). One of the MOMIP was conjugated to a cyclopeptide (i.e., octreotide) and radiolabeled with (111) In. In vitro and in vivo studies of the resulting bioconjugate were conducted, highlighting the potential of these BODIPY-based bimodal probes. This work also confirmed that the biovector and/or the bimodal probes must be chosen carefully, due to the impact of the MOMIP on the overall properties of the resulting imaging agent.
authors.affiliation: ICMUB UMR6302, CNRS, Université Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078 Dijon (France).
authors.forename: Damien
authors.initials: D
authors.lastname: Lhenry
authors.affiliation: ICMUB UMR6302, CNRS, Université Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078 Dijon (France).
authors.forename: Manuel
authors.initials: M
authors.lastname: Larrouy
authors.affiliation: ICMUB UMR6302, CNRS, Université Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078 Dijon (France).
authors.forename: Claire
authors.initials: C
authors.lastname: Bernhard
authors.affiliation: ICMUB UMR6302, CNRS, Université Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078 Dijon (France).
authors.forename: Victor
authors.initials: V
authors.lastname: Goncalves
authors.affiliation: Oncodesign, 20 rue Jean Mazen, BP27627, 21076 Dijon Cedex (France).
authors.forename: Olivier
authors.initials: O
authors.lastname: Raguin
authors.affiliation: Oncodesign, 20 rue Jean Mazen, BP27627, 21076 Dijon Cedex (France).
authors.forename: Peggy
authors.initials: P
authors.lastname: Provent
authors.affiliation: ICMUB UMR6302, CNRS, Université Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078 Dijon (France).
authors.forename: Mathieu
authors.initials: M
authors.lastname: Moreau
authors.affiliation: ICMUB UMR6302, CNRS, Université Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078 Dijon (France).|Centre Georges François Leclerc, Service de médecine nucléaire 1 rue Professeur Marion, BP77980, 21079 Dijon Cedex (France).
authors.forename: Bertrand
authors.initials: B
authors.lastname: Collin
authors.affiliation: Centre Georges François Leclerc, Service de médecine nucléaire 1 rue Professeur Marion, BP77980, 21079 Dijon Cedex (France).
authors.forename: Alexandra
authors.initials: A
authors.lastname: Oudot
authors.affiliation: Centre Georges François Leclerc, Service de médecine nucléaire 1 rue Professeur Marion, BP77980, 21079 Dijon Cedex (France).
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Vrigneaud
authors.affiliation: Centre Georges François Leclerc, Service de médecine nucléaire 1 rue Professeur Marion, BP77980, 21079 Dijon Cedex (France).
authors.forename: François
authors.initials: F
authors.lastname: Brunotte
authors.affiliation: ICMUB UMR6302, CNRS, Université Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078 Dijon (France). christine.goze@u-bourgogne.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Goze
authors.affiliation: ICMUB UMR6302, CNRS, Université Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078 Dijon (France). franck.denat@u-bourgogne.fr.
authors.forename: Franck
authors.initials: F
authors.lastname: Denat
keywords: BODIPY; imaging agents; macrocycles; molecular imaging; optical imaging; positron emission tomography