title: The clinical significance of classical and new emerging determinants of adenomyosis.
abstract: OBJECTIVE
  The present study aims to analyze the diagnostic accuracy of clinical characteristics together with new emerging laboratory markers of adenomyosis.
  
  
  METHODS
  This study was a retrospective analysis of clinical and laboratory characteristics of 99 women who underwent hysterectomies with (study group) or without (control group) a diagnosis of adenomyosis, 56 and 43 patients in each group, respectively.
  
  
  RESULTS
  The women with adenomyosis were more likely to have younger age (OR = 1.14, 0.789-0.971 95% CI, P = 0.010), higher parity (OR = 1.81, 0.308-0.988 95% CI, P = 0.046), higher number of curettage (OR = 1.90, 1.189-3.041 95% CI, P = 0.007), dysmenorrhea (OR = 117.49, 2.715-5084.883 95% CI, P = 0.013) and elevated mean platelet volume (OR = 5.17, 2.054-13.028 95% CI, P = 0.000). After receiver-operating-characteristics curve analysis, using a cut-point of 8.5 fL, the preoperative mean platelet volume predicted adenomyosis with a sensitivity of 56.6% and specificity of 82.6%.
  
  
  CONCLUSIONS
  Those findings suggest gynecologists to give priority on adenomyosis when premenopausal paraous patient with a history of curettages admitted with a complaint of dysmenorrhea and elevated levels of MPV.
authors.affiliation: Department of Obstetrics, Gulhane Military Medical Academy, Gynecology and Reproductive Sciences Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Bodur
authors.affiliation: Department of Obstetrics and Gynecology, GATA Haydarpasa Military Education Hospital Istanbul, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Dundar
authors.affiliation: Department of Obstetrics and Gynecology, Afyon Kocatepe University Medical Faculty Hospital Afyon, Turkey.
authors.forename: Mine Kanat
authors.initials: MK
authors.lastname: Pektas
authors.affiliation: Department of Public and Environmental Health, Gülhane Military Medical Academy Ankara, Turkey.
authors.forename: Mustafa Alparslan
authors.initials: MA
authors.lastname: Babayigit
authors.affiliation: Department of Obstetrics, Gulhane Military Medical Academy, Gynecology and Reproductive Sciences Ankara, Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Ozden
authors.affiliation: Department of Pathology, GATA Haydarpasa Military Education Hospital Istanbul, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Kucukodacı
keywords: Adenomyosis; dysmenorrhea; mean platelet volume