title: Chromosomal Aberrations in Wild Mice Captured in Areas Differentially Contaminated by the Fukushima Dai-Ichi Nuclear Power Plant Accident.
abstract: Following the Fukushima Dai-ichi Nuclear Power Plant accident, radiation effects on nonhuman biota in the contaminated areas have been a great concern. The induction of chromosomal aberrations in splenic lymphocytes of small Japanese field mice (Apodemus argenteus) and house mice (Mus musculus) inhabiting Fukushima Prefecture was investigated. In mice inhabiting the slightly contaminated area, the average frequency of dicentric chromosomes was similar to that seen in mice inhabiting a noncontaminated control area. In contrast, mice inhabiting the moderately and heavily contaminated areas showed a significant increase in the average frequencies of dicentric chromosomes. Total absorbed dose rate was estimated to be approximately 1 mGy d(-1) and 3 mGy d(-1) in the moderately and heavily contaminated areas, respectively. Chromosomal aberrations tended to roughly increase with dose rate. Although theoretically, the frequency of chromosomal aberrations was considered proportional to the absorbed dose, chromosomal aberrations in old mice (estimated median age 300 days) did not increase with radiation dose at the same rate as that observed in young mice (estimated median age 105 days).
authors.affiliation: †Project for Environmental Dynamics and Radiation Effects, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kubota
authors.affiliation: ‡Administration and Planning Unit, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Tsuji
authors.affiliation: †Project for Environmental Dynamics and Radiation Effects, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Taiki
authors.initials: T
authors.lastname: Kawagoshi
authors.affiliation: †Project for Environmental Dynamics and Radiation Effects, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Shiomi
authors.affiliation: §Tokyo Nuclear Services Co., Ltd. 1-3-5 Taito, Taito-ku, Tokyo 110-0016, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: †Project for Environmental Dynamics and Radiation Effects, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: †Project for Environmental Dynamics and Radiation Effects, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Fuma
authors.affiliation: ∥Project for Investigation of Human Health Effects, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Doi
authors.affiliation: †Project for Environmental Dynamics and Radiation Effects, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Kawaguchi
authors.affiliation: ⊥Japan Wildlife Research Center, 3-3-7 Koutoubashi, Sumida-ku, Tokyo 130-8606, Japan.
authors.forename: Masanari
authors.initials: M
authors.lastname: Aoki
authors.affiliation: ⊥Japan Wildlife Research Center, 3-3-7 Koutoubashi, Sumida-ku, Tokyo 130-8606, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Kubota
authors.affiliation: ⊥Japan Wildlife Research Center, 3-3-7 Koutoubashi, Sumida-ku, Tokyo 130-8606, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Furuhata
authors.affiliation: #Japan NUS Co., Ltd., 7-5-25 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Shigemura
authors.affiliation: #Japan NUS Co., Ltd., 7-5-25 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Mizoguchi
authors.affiliation: ×Forestry and Forest Products Research Institute, 1 Matsunosato, Tsukuba, Ibaraki 305-8687, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamada
authors.affiliation: ⊗Department of Biology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8521, Japan.
authors.forename: Morihiko
authors.initials: M
authors.lastname: Tomozawa
authors.affiliation: ○Faculty of Agriculture, University of Miyazaki, Kibana, Miyazaki 889-2192, Japan.
authors.forename: Shinsuke H
authors.initials: SH
authors.lastname: Sakamoto
authors.affiliation: †Project for Environmental Dynamics and Radiation Effects, Fukushima Project Headquarters, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D003411:Arvicolinae; D002453:Cell Cycle / Q000528:radiation effects; D002869:Chromosome Aberrations; D033481:Chromosomes, Mammalian / Q000235:genetics; D004307:Dose-Response Relationship, Radiation; D062406:Fukushima Nuclear Accident; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects; D008677:Metaphase / Q000528:radiation effects; D051379:Mice; D055848:Nuclear Power Plants; D011834:Radiation Monitoring; D011848:Radioactive Pollutants / Q000032:analysis*
chemical_list: D011848:Radioactive Pollutants