title: The role of microRNAs in bone remodeling.
abstract: Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that microRNAs (miRNAs), known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression, and growing numbers of novel miRNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis, and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of miRNAs in regulating bone remodeling as well as novel applications for miRNAs in biomaterials for therapeutic purposes.
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Dian
authors.initials: D
authors.lastname: Jing
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Hao
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Mei-Le
authors.initials: ML
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.|Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China.
authors.forename: Shi-Hu
authors.initials: SH
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Zhi-He
authors.initials: ZH
authors.lastname: Zhao
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D019070:Cell Lineage; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs