title: Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction.
abstract: OBJECTIVE
  To evaluate optical coherence tomography meibography (OCT-M) in patients with and without obstructive meibomian gland dysfunction (MGD) and to determine the relationship between OCT-M and ocular surface clinical tests.
  
  
  METHODS
  Twenty-two patients with MGD and 16 control subjects were included. Each patient underwent an evaluation of ocular surface disease symptoms, lid margin abnormality score, lipid layer thickness evaluation, and meibomian gland (MG) morphological changes using noncontact infrared meibography and OCT-M. OCT-M scans were acquired in 4 different locations. OCT-M parameters including the MG length and width and palpebral conjunctival thickness were evaluated.
  
  
  RESULTS
  Within the OCT-M parameters, the mean length and width of MGs were significantly decreased in patients with MGD (310 ± 60 μm and 214 ± 30 μm, respectively) compared with the control group (361 ± 53 μm, P = 0.041 and 264 ± 41 μm, P = 0.021, respectively). The mean conjunctival thickness was also significantly increased in patients with MGD (448 ± 68 μm) than in the control group (356 ± 59 μm, P = 0.03). The mean length of MGs was correlated with symptoms (r = 0.34, P = 0.034), and the mean MG width was correlated with tear film breakup time (r = -0.412, P = 0.009) and the lid margin abnormality score (r = 0.334, P = 0.038).
  
  
  CONCLUSIONS
  The MG length and width were significantly decreased in patients with MGD than in the control group. These parameters were correlated to both ocular surface symptoms and clinical signs. This new imaging technique may be a useful tool for MGD evaluation.
authors.affiliation: *Department of Ophthalmology, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China; †Department of Ophthalmology, Quinze-Vingts National Ophthalmology Hospital, Paris, and Versailles Saint-Quentin-en-Yvelines University, Versailles, France; and ‡INSERM, U968, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, CNRS, UMR_7210, Paris, France.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Liang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Pan
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Christophe
authors.initials: C
authors.lastname: Baudouin
authors.forename: Antoine
authors.initials: A
authors.lastname: Labbé
mesh_terms: D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D005141:Eyelid Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008537:Meibomian Glands / Q000473:pathology*; D008875:Middle Aged; D015588:Observer Variation; D013666:Tears / Q000737:chemistry; D041622:Tomography, Optical / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult