title: Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans.
abstract: Plants containing resveratrol have been used effectively in traditional medicine for over 2000 years. It can be found in some plants, fruits, and derivatives, such as red wine. Therefore, it can be administered by either consuming these natural products or intaking nutraceutical pills. Resveratrol exhibits a wide range of beneficial properties, and this may be due to its molecular structure, which endow resveratrol with the ability to bind to many biomolecules. Among these properties its activity as an anticancer agent, a platelet antiaggregation agent, and an antioxidant, as well as its antiaging, antifrailty, anti-inflammatory, antiallergenic, and so forth activities, is worth highlighting. These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo. The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol. Clarifying aspects like stability and pharmacokinetics of resveratrol metabolites would be fundamental to understand and apply the therapeutic properties of resveratrol.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Gambini
authors.affiliation: Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Gascó Oliag Street 5, 46010 Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Inglés
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Olaso
authors.affiliation: Sports Research Centre, Miguel Hernández University of Elche, University Avenue, s/n, 03202 Elche, Alicante, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Lopez-Grueso
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Bonet-Costa
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Gimeno-Mallench
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Mas-Bargues
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: K M
authors.initials: KM
authors.lastname: Abdelaziz
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Gomez-Cabrera
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vina
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Borras
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001682:Biological Availability; D006801:Humans; D023421:Models, Animal; D010088:Oxidoreductases / Q000378:metabolism; D000077185:Resveratrol; D037761:Sirtuins / Q000378:metabolism; D013267:Stilbenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D013267:Stilbenes; D010088:Oxidoreductases; D037761:Sirtuins; D000077185:Resveratrol