title: Experimental validation of a nonlinear μFE model based on cohesive-frictional plasticity for trabecular bone.
abstract: Trabecular bone is a porous mineralized tissue playing a major load bearing role in the human body. Prediction of age-related and disease-related fractures and the behavior of bone implant systems needs a thorough understanding of its structure-mechanical property relationships, which can be obtained using microcomputed tomography-based finite element modeling. In this study, a nonlinear model for trabecular bone as a cohesive-frictional material was implemented in a large-scale computational framework and validated by comparison of μFE simulations with experimental tests in uniaxial tension and compression. A good correspondence of stiffness and yield points between simulations and experiments was found for a wide range of bone volume fraction and degree of anisotropy in both tension and compression using a non-calibrated, average set of material parameters. These results demonstrate the ability of the model to capture the effects leading to failure of bone for three anatomical sites and several donors, which may be used to determine the apparent behavior of trabecular bone and its evolution with age, disease, and treatment in the future.
authors.affiliation: University of Bern, Institute for Surgical Technology and Biomechanics, Stauffacherstr. 78, CH-3014, Bern, Switzerland.|EMPA, Swiss Federal Laboratories for Material Science and Technology, Laboratory for Mechanics of Materials and Nanostructures, Feuerwerkerstr. 39, CH-3602, Thun, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Schwiedrzik
authors.affiliation: Vienna University of Technology, Institute of Lightweight Design and Structural Biomechanics, Gusshausstr. 27-29, A-1040, Vienna, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Gross
authors.affiliation: Vienna University of Technology, Institute of Lightweight Design and Structural Biomechanics, Gusshausstr. 27-29, A-1040, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Bina
authors.affiliation: Medical University of Vienna, Department of Applied Anatomy, Währinger Str. 13, A-1090, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Pretterklieber
authors.affiliation: University of Bern, Institute for Surgical Technology and Biomechanics, Stauffacherstr. 78, CH-3014, Bern, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Zysset
authors.affiliation: Vienna University of Technology, Institute of Lightweight Design and Structural Biomechanics, Gusshausstr. 27-29, A-1040, Vienna, Austria.
authors.forename: D
authors.identifier: http://orcid.org/0000-0002-6689-2828
authors.initials: D
authors.lastname: Pahr
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D000071556:Cancellous Bone / Q000502:physiology*; D019245:Compressive Strength; D055119:Elastic Modulus; D020342:Finite Element Analysis; D017276:Friction; D006801:Humans; D017711:Nonlinear Dynamics; D013314:Stress, Mechanical; D055114:X-Ray Microtomography
keywords: cohesive-frictional plasticity; experimental validation; parallel computing; trabecular bone; uniaxial compression/tension; μFE