title: Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8-DMSO: application to the synthesis of vernakalant.
abstract: Ammonium persulfate-dimethyl sulfoxide (APS-DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.
authors.affiliation: CSIR-National Chemical Laboratory, Division of Organic Chemistry, Pune 411 008, India.
authors.forename: Dnyaneshwar N
authors.initials: DN
authors.lastname: Garad
authors.affiliation: CSIR-National Chemical Laboratory, Division of Organic Chemistry, Pune 411 008, India.
authors.forename: Subhash D
authors.initials: SD
authors.lastname: Tanpure
authors.affiliation: CSIR-National Chemical Laboratory, Division of Organic Chemistry, Pune 411 008, India.
authors.forename: Santosh B
authors.initials: SB
authors.lastname: Mhaske
keywords: APS-DMSO; imides; practical synthesis; radical-mediated; vernakalant