title: Evaluation of postoperative antibiotics after non-perforated appendectomy.
abstract: OBJECTIVE
  To evaluate the role of postoperative antibiotics in reducing surgical site infections after appendectomy for non-perforated appendicitis.
  
  
  METHODS
  The randomised controlled trial was conducted at Khyber Teaching Hospital, Peshawar, Pakistan, from November 11, 2012, to May 30, 2014, and comprised patients of emergency appendectomy for non-perforated appendicitis who were divided into groups A and B. Group A received a single dose of cefuroxime sodium and metronidazole half-an-hour before induction, while Group B received one more dose of the same antibiotics postoperatively. Both groups were followed for 6 weeks. SPSS 20 was used for statistical analysis.
  
  
  RESULTS
  Of the 390 patients in the study, 192(49.2%) were in Group A and 198(50.7%) in Group B. Number of surgical site infections was 15(7.8%) in Group A and 18(9.1%) in Group B (p=0.65). Mean hospital stay of 3.32±0.4 days and 3.59±0.46 days was observed for Group A and B, respectively, (p<0.001).
  
  
  CONCLUSIONS
  A single pre-operative dose of cefuroxime and metronidazole had the same efficacy in preventing surgical site infections in cases of non-perforated appendicitis as when the same regimen was repeated post-operatively.
authors.affiliation: Surgical D Unit, Khyber Teaching Hospital, Peshawar, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Muhammad Salman
authors.initials: MS
authors.lastname: Rafiq
authors.affiliation: Surgical D Unit, Khyber Teaching Hospital, Peshawar, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Mah Muneer
authors.initials: MM
authors.lastname: Khan
authors.affiliation: Surgical D Unit, Khyber Teaching Hospital, Peshawar, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Attaullah
authors.initials: A
authors.lastname: Khan
authors.affiliation: Surgical D Unit, Khyber Teaching Hospital, Peshawar, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Hizbullah
authors.initials: H
authors.lastname: Jan
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D001062:Appendectomy; D001064:Appendicitis / Q000628:therapy*; D002444:Cefuroxime / Q000008:administration & dosage*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D011182:Postoperative Care / Q000379:methods*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002444:Cefuroxime
keywords: Acute, Appendicitis, Appendectomy, Antibiotics.