title: Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF4 multifunctional rare earth nanoparticles.
abstract: Ultrasmall sub-5 nm KGdF4 rare earth nanoparticles were synthesized as multifunctional probes for fluorescent, magnetic, and radionuclide imaging. The cytotoxicity of these nanoparticles in human glioblastoma U87MG and human non-small cell lung carcinoma H1299 cells was evaluated, and their application for in vitro and in vivo tumor targeted imaging has also been demonstrated.
authors.affiliation: School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China. xiongliqin@sjtu.edu.cn.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Cao
authors.forename: Fengwen
authors.initials: F
authors.lastname: Cao
authors.forename: Liqin
authors.initials: L
authors.lastname: Xiong
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Tianye
authors.initials: T
authors.lastname: Cao
authors.forename: Xi
authors.initials: X
authors.lastname: Cai
authors.forename: Wangxi
authors.initials: W
authors.lastname: Hai
authors.forename: Biao
authors.initials: B
authors.lastname: Li
authors.forename: Yixiao
authors.initials: Y
authors.lastname: Guo
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fuyou
authors.initials: F
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D008674:Metals, Rare Earth / Q000737:chemistry / Q000633:toxicity*; D051379:Mice; D057054:Molecular Imaging; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000378:metabolism; D049268:Positron-Emission Tomography
chemical_list: D000970:Antineoplastic Agents; D008674:Metals, Rare Earth