title: Correction to Ward et al. (2015).
abstract: Reports an error in "The impact of motivation on cognitive performance in an animal model of the negative and cognitive symptoms of schizophrenia" by Ryan D. Ward, Vanessa Winiger, Kerin K. Higa, Julia B. Kahn, Eric R. Kandel, Peter D. Balsam and Eleanor H. Simpson (Behavioral Neuroscience, 2015[Jun], Vol 129[3], 292-299). There is a text error in the 4th paragraph of the Discussion section. The explanation for the abbreviation OFC was incorrectly listed as occipitofrontal circumference. It should have been orbitofrontal cortex. (The following abstract of the original article appeared in record 2015-18639-001.) Interactions between motivation and cognition are implicated in producing functional impairments and poor quality of life in psychiatric patients. This interaction, however, is not well understood at either the behavioral or neural level. We developed a procedure for mice in which a cognitive measure, sustained attention, is modulated by a motivationally relevant signal that predicts reward probability on a trial-by-trial basis. Using this paradigm, we tested the interaction between motivation and cognition in mice that model the increased striatal D2 receptor activity observed in schizophrenia patients (D2R-OE mice). In control mice, attention was modulated by signaled-reward probability. In D2R-OE mice, however, attention was not modulated by reward-related cues. This impairment was not due to any global deficits in attention or maintenance of the trial-specific information in working memory. Turning off the transgene in D2R-OE mice rescued the motivational modulation of attention. These results indicate that deficits in motivation impair the ability to use reward-related cues to recruit attention and that improving motivation improves functional cognitive performance. These results further suggest that addressing motivational impairments in patients is critical to achieving substantive cognitive and functional gains.
authors.affiliation: Department of Psychology, Columbia University.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Ward
authors.affiliation: Department of Psychology, Columbia University.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Winiger
authors.affiliation: Department of Psychology, Columbia University.
authors.forename: Kerin K
authors.initials: KK
authors.lastname: Higa
authors.affiliation: Department of Psychology, Columbia University.
authors.forename: Julia B
authors.initials: JB
authors.lastname: Kahn
authors.affiliation: Department of Neuroscience and Psychiatry, Columbia University.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Kandel
authors.affiliation: Department of Psychology, Columbia University.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Balsam
authors.affiliation: Department of Neuroscience and Psychiatry, Columbia University.
authors.forename: Eleanor H
authors.initials: EH
authors.lastname: Simpson