title: Blood free fatty acids were not increased in high-fat diet induced obese insulin-resistant animals.
abstract: The close connection between high blood FFA and insulin resistance (IR) in obese individuals is well-known. The purpose of this study was to identify whether the blood FFA increased in obese-IR animals.
  
  
  
  Obese-IR animal models were established using high-fat diet (HFD) or HFD and streptozocin, and treated with drugs.
  
  
  
  The serum FFA of obese-IR animals was not increased, even significantly lower than that of normal animals, and were not significantly decreased when insulin sensitivity and obesity-related indices were ameliorated after treatment.
  
  
  
  The results suggest that blood FFA are unlikely the link between obesity and insulin resistance.
authors.affiliation: Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China; Gansu Provincial Cancer Hospital, Lanzhou, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.affiliation: Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China.
authors.forename: Baolai
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China. Electronic address: cmxlz@163.com.
authors.forename: Mingxia
authors.initials: M
authors.lastname: Cui
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000097:blood* / Q000150:complications; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin
keywords: Ciliary neurotrophic factor; Free fatty acids; Insulin resistance; Obesity; Sibutramine