title: Characteristics of Vibration that Alter Cardiovascular Parameters in Mice.
abstract: We hypothesized that short-term exposure of mice to vibration within a frequency range thought to be near the resonant frequency range of mouse tissue and at an acceleration of 0 to 1 m/s(2) would alter heart rate (HR) and mean arterial pressure (MAP). We used radiotelemetry to evaluate the cardiovascular response to vibration in C57BL/6 and CD1 male mice exposed to vertical vibration of various frequencies and accelerations. MAP was consistently increased above baseline values at an acceleration near 1 m/s(2) and a frequency of 90 Hz in both strains, and HR was increased also in C57BL/6 mice. In addition, MAP increased at 80 Hz in individual mice of both strains. When both strains were analyzed together, mean MAP and HR were increased at 90 Hz at 1 m/s(2), and HR was increased at 80 Hz at 1 m/s(2). No consistent change in MAP or HR occurred when mice were exposed to frequencies below 80 Hz or above 90 Hz. The increase in MAP and HR occurred only when the mice had conscious awareness of the vibration, given that these changes did not occur when anesthetized mice were exposed to vibration. Tested vibration acceleration levels lower than 0.75 m/s(2) did not increase MAP or HR at 80 or 90 Hz, suggesting that a relatively high level of vibration is necessary to increase these parameters. These data are important to establish the harmful frequencies and accelerations of environmental vibration that should be minimized or avoided in mouse facilities.
authors.affiliation: Department of Laboratory Animal Science, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, USA.
authors.forename: Karyne N
authors.initials: KN
authors.lastname: Rabey
authors.affiliation: Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Schmitt
authors.affiliation: The Division of Laboratory Animal Resources, Duke University, Durham, North Carolina, USA.
authors.forename: John N
authors.initials: JN
authors.lastname: Norton
authors.affiliation: The Division of Laboratory Animal Resources, Duke University, Durham, North Carolina, USA. Randall.Reynolds@Duke.edu.
authors.forename: Randall P
authors.initials: RP
authors.lastname: Reynolds
mesh_terms: D000818:Animals; D006339:Heart Rate; D006799:Housing, Animal; D008297:Male; D051379:Mice / Q000502:physiology*; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013312:Stress, Physiological; D014732:Vibration / Q000009:adverse effects*