title: Bioactive cembranoids from the South China Sea soft coral Sarcophyton elegans.
abstract: Four new cembranoids, sarcophelegans A-D (1-4) and six known analogues (5-10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute conﬁguration of 1 was conﬁrmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1-10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. liux66@mail2.sysu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhangjsh0814@163.com.
authors.forename: Junsheng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. 15521123303@163.com.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. tanggh5@mail.sysu.edu.cn.
authors.forename: Guihua
authors.initials: G
authors.lastname: Tang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. whongsh@mail.sysu.edu.cn.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Wang
authors.affiliation: East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China. chengqifan92@pku.org.cn.
authors.forename: Chengqi
authors.initials: C
authors.lastname: Fan
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. yinsh2@mail.sysu.edu.cn.
authors.forename: Sheng
authors.initials: S
authors.lastname: Yin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D006801:Humans
chemical_list: D004224:Diterpenes
keywords: Sarcophyton elegans; antimigratory activity; cembranoids