title: Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring.
abstract: Endocrine disrupting compounds (EDCs) are hypothesized to promote obesity and early puberty but their interactive effects with hormonally active diets are poorly understood. Here we assessed individual and combinatorial effects of soy diet or the isoflavone genistein (GEN; administered as the aglycone genistin GIN) with bisphenol A (BPA) on body weight, ingestive behavior and female puberal onset in Wistar rats. Soy-fed dams gained less weight during pregnancy and, although they consumed more than dams on a soy-free diet during lactation, did not become heavier. Their offspring (both sexes), however, became significantly heavier (more pronounced in males) pre-weaning. Soy also enhanced food intake and accelerated female pubertal onset in the offspring. Notably, pubertal onset was also advanced in females placed on soy diet at weaning. Males exposed to BPA plus soy diet, but not BPA alone, had lighter testes. BPA had no independent effects.
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Roger
authors.initials: R
authors.lastname: Echelberger
authors.affiliation: Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Sluzas
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: McCaffrey
authors.affiliation: Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Buckley
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: hbpatisa@ncsu.edu.
authors.forename: Heather B
authors.initials: HB
authors.lastname: Patisaul
mesh_terms: D000367:Age Factors; D000824:Animal Nutritional Physiological Phenomena / Q000187:drug effects; D000818:Animals; D001559:Benzhydryl Compounds / Q000378:metabolism / Q000633:toxicity*; D004044:Dietary Proteins / Q000378:metabolism / Q000633:toxicity*; D004435:Eating / Q000187:drug effects*; D052244:Endocrine Disruptors / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D019833:Genistein / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena / Q000187:drug effects; D009752:Nutritional Status / Q000187:drug effects; D009765:Obesity / Q000139:chemically induced / Q000503:physiopathology; D010636:Phenols / Q000378:metabolism / Q000633:toxicity*; D048789:Phytoestrogens / Q000378:metabolism / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017208:Rats, Wistar; D018570:Risk Assessment; D012741:Sexual Maturation / Q000187:drug effects*; D030262:Soybean Proteins / Q000378:metabolism / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004044:Dietary Proteins; D052244:Endocrine Disruptors; D019833:Genistein; D010636:Phenols; D048789:Phytoestrogens; D030262:Soybean Proteins; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Behavior; Body weight; Endocrine disruption; Genistein; Metabolic; Obesogen; Phytoestrogens; Sexually dimorphic