title: Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study.
abstract: BACKGROUND
  Simvastatin, a common cholesterol-lowering drug that inhibits hepatic hydroxymethylglutaryl coenzyme A reductase, the rate-limiting enzyme in the mevalonate pathway, increases expression of the BMP-2 gene and thus promotes bone regeneration.
  
  
  METHODS
  A study was conducted in mandibular third molar sockets to study the efficacy of the drug by implanting it into sockets (experimental group) and observations were made over 3 months to compare the healing with the (control group).
  
  
  CONCLUSIONS
  The results showed faster regeneration of the bone in the simvastatin site using the gray level histogram values.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Rishiraj College of Dental Sciences and Research Centre, Bhopal, India.
authors.forename: Anil Singh
authors.initials: AS
authors.lastname: Chauhan
authors.affiliation: Department of Oral and Maxillofacial Surgery, Rishiraj College of Dental Sciences and Research Centre, Bhopal, India.
authors.forename: Anisha
authors.initials: A
authors.lastname: Maria
authors.affiliation: Department of Oral and Maxillofacial Surgery, Rishiraj College of Dental Sciences and Research Centre, Bhopal, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Managutti
keywords: Bone regeneration; Simvastatin; Third molar sockets