title: Rheumatoid Factor, Anti-Cyclic Citrullinated Peptide Antibody, C-Reactive Protein, and Erythrocyte Sedimentation Rate for the Clinical Diagnosis of Rheumatoid Arthritis.
abstract: OBJECTIVE
  To explore the value of rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody, C-reactive protein (CRP), and the erythrocyte sedimentation rate (ESR) in the diagnosis of rheumatoid arthritis (RA).
  
  
  METHODS
  Using rate nephelometry, chemiluminescence microparticle immunoassay (CMIA), and Westergren sedimentation rate testing, we detected RF, anti-CCP antibody, CRP, and ESR in 134 patients with RA and 50 healthy control individuals.
  
  
  RESULTS
  We observed significant differences in RF, anti-CCP antibody, CRP, and ESR concentrations between the RA and control groups (P <.01). The sensitivity, specificity and accuracy in the diagnosis of RA were 91.0%, 74.4%, and 87.0%, respectively, for RF; 88.0%, 90.4%, and 88.1%, respectively, for anti-CCP antibody; and 90.2%, 83.3%, and 89.5%, respectively, for the detection of RA via the combination of RF and anti-CCP antibody.
  
  
  CONCLUSIONS
  Anti-CCP is more specific than the other parameters we reviewed for the diagnosis of RA. Combined detection of the 4 parameters is beneficial when confirming a diagnosis of RA.
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Rongchun
authors.initials: R
authors.lastname: Shen
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Ren
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Jing
authors.affiliation: Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Xianjuan
authors.initials: X
authors.lastname: Shen
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Chen
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Ju
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China jsq814@hotmail.com.
authors.forename: Chunlan
authors.initials: C
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis*; D001323:Autoantibodies; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000097:blood* / Q000276:immunology*; D012217:Rheumatoid Factor / Q000097:blood*; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D002097:C-Reactive Protein; D012217:Rheumatoid Factor
keywords: C-reactive protein; anti-cyclic citrullinated peptide antibody; clinical diagnosis; erythrocyte sedimentation rate; rheumatoid arthritis; rheumatoid factor