title: Hypnosis and music interventions (HMIs) inactivate HIF-1: A potential curative efficacy for cancers and hypertension.
abstract: Hypnosis and music interventions (HMIs) have shown positive influence on cancers for nearly 200years, but the underlying mechanisms were rarely explored systematically. The hypothesis suggests a potential curative efficacy of HMIs on cancers by inhibiting hypoxia inducible factor-1 (HIF-1), which is a key mediator of cancer development, especially under hypoxic conditions. HMIs are sufficient to attenuate the pain and anxiety degree of individuals, improve multiple psychological and physiological parameters, and consequently, lead to increased oxygen saturation in vivo. Furthermore, abundant oxygen in vivo inhibits the activation of HIF-1 and potentially blockades kinds of HIF-1-induced oncogenic signaling pathways. The hypothesized efficacy of HMIs is very similar to anti-cancer medicines targeting HIF-1. The implication of the hypothesis in preventing hypertension is also discussed. In summary, the hypothesis clearly suggests the potential involvement of the convenient, safe, non-pharmaceutical, and low-cost HMIs in preventing HIF-1-mediated diseases, including cancers and hypertension.
authors.affiliation: Department of Medical Technology, Affiliated Hospital, College of Medicine, Hebei University of Engineering, Handan 056002, PR China. Electronic address: wangjingzhang1981@gmail.com.
authors.forename: Jing-Zhang
authors.initials: JZ
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Affiliated Hospital, College of Medicine, Hebei University of Engineering, Handan 056002, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Affiliated Hospital, College of Medicine, Hebei University of Engineering, Handan 056002, PR China.
authors.forename: Li-Lan
authors.initials: LL
authors.lastname: Pan
authors.affiliation: Department of Medical Technology, Affiliated Hospital, College of Medicine, Hebei University of Engineering, Handan 056002, PR China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Chen
mesh_terms: D006801:Humans; D006973:Hypertension / Q000628:therapy*; D006990:Hypnosis; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors*; D008962:Models, Theoretical; D009147:Music Therapy; D009369:Neoplasms / Q000628:therapy*
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit