title: Perfusion computed tomography in renal cell carcinoma.
abstract: Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma (RCC). While contrast enhanced computed tomography (CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT (pCT), goes down to the molecular level and provides new perspectives in imaging of RCC. pCT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using pCT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of pCT in staging and response assessment in patients with RCCs.
authors.affiliation: Chandan J Das, Usha Thingujam, Ananya Panda, Sanjay Sharma, Arun Kumar Gupta, Department of Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Chandan J
authors.initials: CJ
authors.lastname: Das
authors.affiliation: Chandan J Das, Usha Thingujam, Ananya Panda, Sanjay Sharma, Arun Kumar Gupta, Department of Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Usha
authors.initials: U
authors.lastname: Thingujam
authors.affiliation: Chandan J Das, Usha Thingujam, Ananya Panda, Sanjay Sharma, Arun Kumar Gupta, Department of Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Ananya
authors.initials: A
authors.lastname: Panda
authors.affiliation: Chandan J Das, Usha Thingujam, Ananya Panda, Sanjay Sharma, Arun Kumar Gupta, Department of Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Chandan J Das, Usha Thingujam, Ananya Panda, Sanjay Sharma, Arun Kumar Gupta, Department of Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Gupta
keywords: Angiogenesis; Anti-angiogenic therapy; Perfusion computed tomography; Renal cell carcinoma