title: Diagnostic accuracy of left ventricular longitudinal function by speckle tracking echocardiography to predict significant coronary artery stenosis. A systematic review.
abstract: BACKGROUND
  Patients evaluated for acute and chronic chest pain comprise a large, heterogeneous group that often provides diagnostic challenges. Although speckle tracking echocardiography (STE) has proved to have diagnostic value in acute coronary syndrome it is not commonly incorporated in everyday practice. The purpose of the present systematic review was to assess the diagnostic accuracy of left ventricular (LV) longitudinal function by STE to predict significant coronary artery stenosis (CAD+) or not (CAD-) verified by coronary angiography in patients with chest pain suspected to be of cardiac ischemic origin.
  
  
  METHODS
  4 electronic databases; Embase, Medline, Cochrane and PubMed ahead-of print were searched for per 19.05.14. Only full-sized articles including >40 patients were selected.
  
  
  RESULTS
  A total of 166 citations were identified, 16 full-size articles were assessed of which 6 were found eligible for this review. Of 781 patients included 397 (60%) had CAD+. The overall weighted mean global longitudinal strain (GLS) was -17.2% (SD=2.6) among CAD+ vs. -19.2% (SD=2.8) in CAD- patients. Mean area under curve in 4 studies for predicting CAD+ ranged from 0.68 to 0.80. The study cut-off levels for prediction of CAD+ in the ROC analysis varied between -17.4% and -19.7% with sensitivity from 51% to 81% and specificity between 58% and 81%. In 1 study GLS obtained during dobutamine stress echocardiography (DSE) had the best accuracy. Regional strain measurements were not uniform, but may have potential in detecting CAD.
  
  
  CONCLUSIONS
  GLS measurements at rest only have modest diagnostic accuracy in predicting CAD+ among patients presenting with acute or chronic chest pain. The results from regional strain, layer specific strain and DSE need to be verified in larger studies.
authors.affiliation: Department of Cardiology, Vestfold Hospital Trust, Pb 2168, 3103, Tønsberg, Norway. ingvild.billehaug.norum@siv.no.|University of Oslo, Faculty of Medicine, Pb 1078 , Blindern, 0316, Oslo, Norway. ingvild.billehaug.norum@siv.no.
authors.forename: Ingvild Billehaug
authors.initials: IB
authors.lastname: Norum
authors.affiliation: Department of Cardiology, Vestfold Hospital Trust, Pb 2168, 3103, Tønsberg, Norway. vidar.ruddox@siv.no.|University of Oslo, Faculty of Medicine, Pb 1078 , Blindern, 0316, Oslo, Norway. vidar.ruddox@siv.no.
authors.forename: Vidar
authors.initials: V
authors.lastname: Ruddox
authors.affiliation: University of Oslo, Faculty of Medicine, Pb 1078 , Blindern, 0316, Oslo, Norway. thor.edvardsen@medisin.uio.no.|Department of Cardiology, Oslo University Hospital, Rikshospitalet, Pb 4950, Nydalen, 0424, Oslo, Norway. thor.edvardsen@medisin.uio.no.
authors.forename: Thor
authors.initials: T
authors.lastname: Edvardsen
authors.affiliation: Department of Cardiology, Vestfold Hospital Trust, Pb 2168, 3103, Tønsberg, Norway. jan.erik.otterstad@siv.no.
authors.forename: Jan Erik
authors.initials: JE
authors.lastname: Otterstad
mesh_terms: D023921:Coronary Stenosis / Q000150:complications* / Q000000981:diagnostic imaging*; D004452:Echocardiography / Q000379:methods*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology*