title: Visual and Non-Visual Navigation in Blind Patients with a Retinal Prosthesis.
abstract: Human adults with normal vision can combine visual landmark and non-visual self-motion cues to improve their navigational precision. Here we asked whether blind individuals treated with a retinal prosthesis could also benefit from using the resultant new visual signal together with non-visual information when navigating. Four patients (blind for 15-52 years) implanted with the Argus II retinal prosthesis (Second Sight Medical Products Inc. Sylmar, CA), and five age-matched and six younger controls, participated. Participants completed a path reproduction and a triangle completion navigation task, using either an indirect visual landmark and non-visual self-motion cues or non-visual self-motion cues only. Control participants wore goggles that approximated the field of view and the resolution of the Argus II prosthesis. In both tasks, control participants showed better precision when navigating with reduced vision, compared to without vision. Patients, however, did not show similar improvements when navigating with the prosthesis in the path reproduction task, but two patients did show improvements in the triangle completion task. Additionally, all patients showed greater precision than controls in both tasks when navigating without vision. These results indicate that the Argus II retinal prosthesis may not provide sufficiently reliable visual information to improve the precision of patients on tasks, for which they have learnt to rely on non-visual senses.
authors.affiliation: Institute of Ophthalmology, University College London (UCL), London, United Kingdom.
authors.forename: Sara
authors.initials: S
authors.lastname: Garcia
authors.affiliation: Institute of Ophthalmology, University College London (UCL), London, United Kingdom; Department of Psychology, University of Bath, Bath, United Kingdom.
authors.forename: Karin
authors.initials: K
authors.lastname: Petrini
authors.affiliation: Institute of Ophthalmology, University College London (UCL), London, United Kingdom; (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Rubin
authors.affiliation: Institute of Ophthalmology, University College London (UCL), London, United Kingdom; (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom; Vitreoretinal Service, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
authors.forename: Lyndon
authors.initials: L
authors.lastname: Da Cruz
authors.affiliation: Institute of Ophthalmology, University College London (UCL), London, United Kingdom; Department of Psychology, Durham University, Durham, United Kingdom.
authors.forename: Marko
authors.initials: M
authors.lastname: Nardini
mesh_terms: D000368:Aged; D001766:Blindness / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057488:Visual Prosthesis