title: Current trends in nanomaterial embedded field effect transistor-based biosensor.
abstract: Recently, as metal-, polymer-, and carbon-based biocompatible nanomaterials have been increasingly incorporated into biosensing applications, with various nanostructures having been used to increase the efficacy and sensitivity of most of the detecting devices, including field effect transistor (FET)-based devices. These nanomaterial-based methods also became the ideal for the amalgamation of biomolecules, especially for the fabrication of ultrasensitive, low-cost, and robust FET-based biosensors; these are categorically very successful at binding the target specified entities in the confined gated micro-region for high functionality. Furthermore, the contemplation of nanomaterial-based FET biosensors to various applications encompasses the desire for detection of many targets with high selectivity, and specificity. We assess how such devices have empowered the achievement of elevated biosensor performance in terms of high sensitivity, selectivity and low detection limits. We review the recent literature here to illustrate the diversity of FET-based biosensors, based on various kinds of nanomaterials in different applications and sum up that graphene or its assisted composite based FET devices are comparatively more efficient and sensitive with highest signal to noise ratio. Lastly, the future prospects and limitations of the field are also discussed.
authors.affiliation: Nanobiotechnology Research Laboratory, Centre of Excellence for Mountain Biology, Uttarakhand Council for Biotechnology, Biotech Bhavan, Haldi, 263146 U.S. Nagar, Uttarakhand, India.
authors.forename: Anuj
authors.initials: A
authors.lastname: Nehra
authors.affiliation: Bio-Nanotechnology Research Laboratory, Biophysics Unit, CBSH, G.B. Pant University of Agriculture & Technology, Pantnagar, 263145 U.S. Nagar, Uttarakhand, India. Electronic address: kps_biophysics@yahoo.co.in.
authors.forename: Krishna
authors.initials: K
authors.lastname: Pal Singh
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000639:trends; D003217:Conductometry / Q000295:instrumentation* / Q000639:trends; D004553:Electric Conductivity; D004867:Equipment Design; D008839:Microelectrodes / Q000639:trends*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation* / Q000639:trends; D013673:Technology Assessment, Biomedical; D014173:Transistors, Electronic / Q000639:trends*
keywords: Biocompatible; Graphene; Nanobiosensors; Nanomaterial; Nanotechnology