title: Primary hepatoid carcinoma of the ovary: a case report.
abstract: Primary hepatoid carcinoma of the ovary (HCO) is a very rare type of high-grade invasive malignant ovarian tumor with hepatic differentiation and production of α-fetoprotein (AFP). We describe a 78-year-old Moroccan woman who presented to our hospital with abdominal distension and purplish nodules infiltrating the para umbilical skin with weight loss and impairment of her performance status. Excisional biopsy of the para umbilical nodule revealed a cutaneous localization of moderately differentiated adenocarcinoma and pelvic ultrasonography noted the presence of a tumoral right adnexal mass. The patient underwent an exploratory laparoscopy which found peritoneal carcinomatosis with pelvic adhesions allowing only a peritoneal biopsy. Diagnosis of primary hepatoid carcinoma of the ovary was established on the basis of classic histopathologic findings, immunohistochemical staining and marked elevation in serum of α-fetoprotein more than the carbohydrate antigen 125. The patient received 3 cycles of chemotherapy based on Carboplatin and Paclitaxel with disease progression. No second line chemotherapy was given because of the drop of patient's performance status to 3. The patient died one month later.
authors.affiliation: Department of Medical Oncology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Aicha
authors.initials: A
authors.lastname: Mazouz
authors.affiliation: Department of Medical Oncology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Lamiae
authors.initials: L
authors.lastname: Amaadour
authors.affiliation: Department of Pathology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Hassania
authors.initials: H
authors.lastname: Ameurtesse
authors.affiliation: Department of Pathology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Laila
authors.initials: L
authors.lastname: Chban
authors.affiliation: Department of Pathology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Afaf
authors.initials: A
authors.lastname: Amarti
authors.affiliation: Laboratory of Pathology, Avenue Nations Unies, Rabat, Morocco.
authors.forename: Fouad
authors.initials: F
authors.lastname: Kettani
authors.affiliation: Department of Radiology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Omar
authors.initials: O
authors.lastname: Addou
authors.affiliation: Department of Radiology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Siham
authors.initials: S
authors.lastname: Tizniti
authors.affiliation: Department of Medical Oncology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Nawfel
authors.initials: N
authors.lastname: Mellas
authors.affiliation: Department of Medical Oncology, Hassan II University Hospital, Fez, Morocco.
authors.forename: Samia
authors.initials: S
authors.lastname: Arifi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D014463:Ultrasonography
keywords: Hepatoid carcinoma of the ovary; alpha-fetoprotein; immunohistochemical staining