title: Liver transplantation as a definitive treatment for familial hypercholesterolemia: A series of 36 cases.
abstract: FH is a genetic disorder characterized by an increase in serum LDL and total cholesterol values. The afflicted patients are at increased risk of premature atherosclerosis and myocardial infarction. Different treatment modalities are present, including pharmacological agents and surgical procedures. The most effective method of therapy in refractive cases is liver transplantation. Herein, we report our experience on 36 cases of patients with FH undergoing liver transplantation in our center, the main referral center of liver transplantation in Iran. The clinical findings, hospital courses, post-operative complications, and patient follow-up are also described.
authors.affiliation: Surgery Department, Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohsenreza
authors.initials: M
authors.lastname: Mansoorian
authors.affiliation: Surgery Department, Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Kazemi
authors.affiliation: Surgery Department, Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Saman
authors.initials: S
authors.lastname: Nikeghbalian
authors.affiliation: Surgery Department, Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Shamsaeefar
authors.affiliation: Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Maral
authors.initials: M
authors.lastname: Mokhtari
authors.affiliation: Pediatric Gastroenterology and Hepatology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Seyed Mohsen
authors.initials: SM
authors.lastname: Dehghani
authors.affiliation: Surgery Department, Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ali
authors.identifier: http://orcid.org/0000-0003-3798-6064
authors.initials: A
authors.lastname: Bahador
authors.affiliation: Surgery Department, Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Heshmatollah
authors.initials: H
authors.lastname: Salahi
authors.affiliation: Cardiac and Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Amoozgar
authors.affiliation: Surgery Department, Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Malek Hosseini
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: familial hypercholesterolemia; liver; transplantation