title: Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues.
abstract: The extracellular matrix (ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions. Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2 (Matn2) in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissues and in tumorigenesis. As a multiadhesion adaptor protein, it interacts with other ECM proteins and integrins. Matn2 promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing. Matn2 deposition by myoblasts is crucial for the timely induction of the global switch toward terminal myogenic differentiation during muscle regeneration by affecting transforming growth factor beta/bone morphogenetic protein 7/Smad and other signal transduction pathways. Depending on the type of tissue and the pathomechanism, Matn2 can also promote or suppress tumor growth.
authors.affiliation: Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, 48149 Muenster, Germany ; Cells-in-Motion Cluster of Excellence, University of Muenster, 48149 Muenster, Germany.
authors.forename: Éva
authors.initials: É
authors.lastname: Korpos
authors.affiliation: Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, H-6701 Szeged, Hungary ; Avidin Ltd., H-6726 Szeged, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Deák
authors.affiliation: Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, H-6701 Szeged, Hungary ; Avidin Ltd., H-6726 Szeged, Hungary.
authors.forename: Ibolya
authors.initials: I
authors.lastname: Kiss
keywords: Schwann cells; TGF-β/BMP-7/Smad signaling; Trf3; multiple sclerosis; myogenic differentiation; neurite outgrowth; neuromuscular junction (NMJ); tumor suppression