title: Adverse Prenatal, Perinatal and Neonatal Experiences in Children with Anxiety Disorders.
abstract: This study examined the incidence of adverse prenatal, perinatal, and neonatal experiences amongst children with anxiety disorders, and the relationship to clinical symptomology and functional impairment in treatment-seeking children (N = 107) with a primary anxiety disorder. Anxious children had higher rates of reported maternal prescription medication use during pregnancy, maternal smoking and illness during pregnancy and neonatal complications (including neonatal intensive care and feeding issues) compared with population base rates and non-affected children. Almost one-third had early problems with sleep. Developmental problems were common with more than half having at least one area of delay. More than three quarters of anxious children had a first-degree family member with a psychiatric history. There were several associations between neonatal complications and subsequent clinical symptomology, including attention deficit hyperactivity disorder and depressive comorbidity, anxiety severity and functional impairment. Findings suggest higher rates of perinatal complications in anxious children.
authors.affiliation: Department of Pediatrics, University of South Florida, Tampa, FL, USA. cjohnco@health.usf.edu.
authors.forename: Carly
authors.identifier: http://orcid.org/0000-0002-2212-507X
authors.initials: C
authors.lastname: Johnco
authors.affiliation: Department of Pediatrics, University of South Florida, Tampa, FL, USA.|Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA.|Department of Psychology, University of South Florida, Tampa, FL, USA.
authors.forename: Adam B
authors.initials: AB
authors.lastname: Lewin
authors.affiliation: Department of Social Work, University of South Florida, Tampa, FL, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Salloum
authors.affiliation: Department of Pediatrics, University of South Florida, Tampa, FL, USA.|Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA.|All Children's Hospital - Johns Hopkins Medicine, St. Petersburg, FL, USA.
authors.forename: Tanya K
authors.initials: TK
authors.lastname: Murphy
authors.affiliation: Department of Psychology, Temple University, Philadelphia, PA, USA.
authors.forename: Erika A
authors.initials: EA
authors.lastname: Crawford
authors.affiliation: Department of Pediatrics, University of South Florida, Tampa, FL, USA.
authors.forename: Brittney F
authors.initials: BF
authors.lastname: Dane
authors.affiliation: Department of Pediatrics, University of South Florida, Tampa, FL, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: McBride
authors.affiliation: Department of Pediatrics, University of South Florida, Tampa, FL, USA.|Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA.|Department of Psychology, University of South Florida, Tampa, FL, USA.|Rogers Behavioral Health - Tampa Bay, Tampa, FL, USA.|All Children's Hospital - Johns Hopkins Medicine, St. Petersburg, FL, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Storch
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000453:epidemiology*; D002648:Child; D015897:Comorbidity; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000453:epidemiology*; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012720:Severity of Illness Index; D012907:Smoking / Q000453:epidemiology*
keywords: Anxiety; Child; Neonatal; Obstetric; Perinatal; Prenatal