title: Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population.
abstract: BACKGROUND
  It has been suggested that the single nucleotide polymorphism (SNP) of the CYP19A1 gene encoding aromatase may affect the development of female pattern hair loss (FPHL).
  
  
  OBJECTIVE
  Our aim was to investigate the association of CYP19A1 gene SNPs with FPHL in a Chinese population.
  
  
  METHODS
  Two hundred Chinese Han patients with FPHL and 200 controls were enrolled into our study. SNaPshot technology was used to detect CYP19A1 gene candidate SNPs.
  
  
  RESULTS
  The allele frequencies and distributions of rs6493497 and rs7176005 were significantly different between FPHL and control subjects (p < 0.001 and p < 0.001 vs. p < 0.001 and p = 0.003).
  
  
  CONCLUSIONS
  The rs6493497 and rs7176005 SNPs of the CYP19A1 gene may be genetic markers that influence the risk of FPHL in this Chinese population.
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Rui
authors.forename: Youyu
authors.initials: Y
authors.lastname: Sheng
authors.forename: Ruiming
authors.initials: R
authors.lastname: Hu
authors.forename: Ying
authors.initials: Y
authors.lastname: Miao
authors.forename: Yumei
authors.initials: Y
authors.lastname: Han
authors.forename: Xia
authors.initials: X
authors.lastname: Guo
authors.forename: Sisi
authors.initials: S
authors.lastname: Qi
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xu
authors.forename: Qinping
authors.initials: Q
authors.lastname: Yang
mesh_terms: D000328:Adult; D000505:Alopecia / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D001141:Aromatase / Q000235:genetics* / Q000378:metabolism; D002681:China / Q000453:epidemiology; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance / Q000379:methods*
chemical_list: D005819:Genetic Markers; D004247:DNA; D001141:Aromatase; C561410:CYP19A1 protein, human