title: Microribonucleic acid dysregulations in children and adolescents with obsessive-compulsive disorder.
abstract: OBJECTIVE
  Obsessive-compulsive disorder (OCD) is a disorder characterized by the presence of obsessions and/or compulsions. Although disorder etiology and pathogenesis remains unknown, several theories about OCD development have been proposed, and many researchers believe that it is caused by both genetic and environmental factors. In the current study, our aim was to investigate miRNA levels in OCD.
  
  
  METHODS
  In the current study, we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p, and miR155a-5p levels in child and adolescent OCD patients. The research sample consisted of a group of 23 OCD patients and 40 healthy volunteer controls.
  
  
  RESULTS
  There was no significant difference in age and sex between the two groups (P>0.05). The levels of miR22-3p, miR24-3p, miR106b-5p, miR125b-5p, and miR155a-5p were significantly increased in the OCD subjects (P≤0.05). There were no statistically significant differences in miR18a-5p or miR107 levels between groups (P≥0.05).
  
  
  CONCLUSIONS
  There could be a close relationship between levels of circulating miRNAs and OCD. If we could understand how the signaling pathways arranged by miRNAs impact on central nervous system development, function, and pathology, this understanding could improve our knowledge about OCD etiology and treatment.
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kandemir
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Erdal
authors.affiliation: Harris County Psychiatric Center, University of Texas Health Science Center at Houston, TX, USA.
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: İzci Ay
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
authors.forename: İbrahim Fatih
authors.initials: İF
authors.lastname: Karababa
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Mustafa Ertan
authors.initials: ME
authors.lastname: Ay
authors.affiliation: Department of Psychiatry, Balıklıgöl State Hospital, Şanlıurfa, Turkey.
authors.forename: Sultan Basmacı
authors.initials: SB
authors.lastname: Kandemir
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Şenay Görücü
authors.initials: ŞG
authors.lastname: Yılmaz
authors.affiliation: Department of Psychiatry, Balıklı Rum Hospital, Istanbul, Turkey.
authors.forename: Suat
authors.initials: S
authors.lastname: Ekinci
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Taşdelen
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Bayazit
keywords: OCD; child psychiatry; miRNA; micro RNA; psychiatry