title: Axial Myopia Is Associated with Visual Field Prognosis of Primary Open-Angle Glaucoma.
abstract: OBJECTIVE
  To identify whether myopia was associated with the visual field (VF) progression of primary open-angle glaucoma (POAG).
  
  
  METHODS
  A total of 270 eyes of 270 POAG followed up for more than 3 years with ≥9 reliable VFs by Octopus perimetry were retrospectively reviewed. Myopia was divided into: mild myopia (-2.99 diopter [D], 0), moderate myopia (-5.99, 3.00 D), marked myopia (-9.00, -6.00 D) and non-myopia (0 D or more). An annual change in the mean defect (MD) slope >0.22 dB/y and 0.30 dB/y was defined as fast progression, respectively. Logistic regression was performed to determine prognostic factors for VF progression.
  
  
  RESULTS
  For the cutoff threshold at 0.22 dB/y, logistic regression showed that vertical cup-to-disk ratio (VCDR; p = 0.004) and the extent of myopia (p = 0.002) were statistically significant. When logistic regression was repeated after excluding the extent of myopia, axial length (AL; p = 0.008, odds ratio [OR] = 0.796) reached significance, as did VCDR (p = 0.001). Compared to eyes with AL≤23 mm, the OR values were 0.334 (p = 0.059), 0.309 (p = 0.044), 0.266 (p = 0.019), 0.260 (p = 0.018), respectively, for 23 <AL≤24 mm, 24 <AL≤25 mm, 25 <AL ≤26 mm, and AL>26 mm. The significance of vertical cup-to-disk ratio of (p = 0.004) and the extent of myopia (p = 0.008) did not change for the cutoff threshold at 0.30dB/y.
  
  
  CONCLUSIONS
  VCDR and myopia were associated with VF prognosis of POAG. Axial myopia may be a protective factor against VF progression.
authors.affiliation: Department of Ophthalmology, Eye and Ear, Nose, Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Qiu
authors.affiliation: Department of Ophthalmology, Eye and Ear, Nose, Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Shaohong
authors.initials: S
authors.lastname: Qian
authors.affiliation: Department of Ophthalmology, Eye and Ear, Nose, Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China; Key Laboratory of Myopia, Ministry of Health (Fudan University), Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China.
authors.forename: Xinghuai
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Ophthalmology, First People's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Chuandi
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, Eye and Ear, Nose, Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Fanrong
authors.initials: F
authors.lastname: Meng
mesh_terms: D000328:Adult; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis; D014794:Visual Fields