title: Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature.
abstract: Fungi are unusually rare causes of gastric perforation, with most cases of gastric perforation occurring as complications of peptic ulcer disease (PUD), nonsteroidal anti-inflammatory drugs (NSAIDs) and gastric neoplasms. Here, we report the case of a 70-year-old Nigerian male who presented with severe epigastric pain, with no associated history of PUD, NSAIDs use or gastric neoplasm. An emergency exploratory laparotomy was performed and a gastric perforation was discovered and repaired. Histopathological examination of the gastric perforation edge biopsy revealed an intense Candida growth consisting of numerous fungal spores and hyphae invading and destroying the gastric wall. He was subsequently treated with fluconazole antifungal and discharged home after an uneventful postoperative period.
authors.affiliation: Department of Morbid Anatomy, University of Nigeria, Enugu Campus, Enugu/University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria.
authors.forename: F I
authors.initials: FI
authors.lastname: Ukekwe
authors.affiliation: Division of General Surgery, Department of Surgery, University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria.
authors.forename: C
authors.initials: C
authors.lastname: Nwajiobi
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
authors.forename: M O
authors.initials: MO
authors.lastname: Agbo
authors.affiliation: Department of Medical Microbiology, University of Nigeria, Enugu Campus, Enugu/University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria.
authors.forename: S O
authors.initials: SO
authors.lastname: Ebede
authors.affiliation: Department of Morbid Anatomy, University of Nigeria, Enugu Campus, Enugu/University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria.
authors.forename: A O
authors.initials: AO
authors.lastname: Eni
keywords: Candidiasis; Fluconazole; Gastric perforation; Peritonitis; Surgical pathology