title: The potential of L-shell X-ray fluorescence CT (XFCT) for molecular imaging.
abstract: X-ray fluorescence CT (XFCT), a novel modality proposed for high-sensitivity high-resolution molecular imaging of probes labelled with a high atomic-number element, has been performed with high-energy K-shell X-rays. XFCT performed with low-energy L-shell X-rays could, in principle, result in an increase of XFCT imaging sensitivity; however, the significant L-shell X-ray attenuation limits its use for imaging of small objects. This commentary discusses the advantages and drawbacks of L-shell XFCT imaging.
authors.affiliation: 1 Department of Radiation Oncology, Stanford University, Stanford, CA, USA.|2 Department of Physics and Astronomy, University of Victoria, Victoria, BC, Canada.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bazalova-Carter
mesh_terms: D005453:Fluorescence; D006801:Humans; D053768:Metal Nanoparticles; D057054:Molecular Imaging / Q000379:methods*; D011829:Radiation Dosage; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*