title: Seminal anti-Müllerian hormone levels during recombinant human follicle-stimulating hormone treatment in men with idiopathic infertility undergoing assisted reproduction cycles.
abstract: A prospective study was designed to investigate the effects of recombinant human follicle-stimulating hormone (rhFSH) on seminal anti-Müllerian hormone (AMH) levels in men with idiopathic oligoasthenoteratozoospermia (iOAT), researching possible relationships between the seminal AMH behavior and the response to the treatment. Thirty-nine men who were candidates for intracytoplasmic sperm injection (ICSI) because of iOAT were enrolled. Patients were treated on alternately days with 150 IU of rhFSH for at least 3 months before assisted reproduction cycles. Main outcome measures were seminal AMH concentrations before and after rhFSH therapy. After treatment, 16 subjects (responders) showed an improvement in their sperm count compared to baseline (7.6 ± 2.9 vs. 19.3 ± 7.7, p < 0.01) whereas 23 men (non-responders) experienced no sperm modifications. Baseline seminal AMH concentrations were significantly higher in responders than in non-responders (53.0 ± 30.6 vs. 34.6 ± 18.5, p < 0.025). Following therapy, a greater increase in AMH levels was observed in responders compared to non-responders (Δ = 24.8 ± 36.4 vs. Δ = 6.4 ± 11.2, p < 0.028). Seminal AMH levels significantly and positively correlated with sperm count (after rhFSH treatment rho = 0.647, p < 0.001). Our study suggests that rhFSH improves sperm count in a quota of iOAT men, and the subjects who respond to the treatment have higher baseline seminal AMH concentrations than the patients who are not responsive. Seminal AMH could be helpful to select those infertile men who may benefit from rhFSH treatment.
authors.affiliation: Outpatient Fertility Unit, Second University of Naples, Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Caprio
authors.affiliation: Outpatient Fertility Unit, Second University of Naples, Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: De Franciscis
authors.affiliation: Outpatient Fertility Unit, Second University of Naples, Naples, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Trotta
authors.affiliation: Outpatient Fertility Unit, Second University of Naples, Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ianniello
authors.affiliation: Outpatient Fertility Unit, Second University of Naples, Naples, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Mele
authors.affiliation: Outpatient Fertility Unit, Second University of Naples, Naples, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Colacurci
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000032:analysis*; D053627:Asthenozoospermia / Q000188:drug therapy*; D043373:Follicle Stimulating Hormone, Human / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D054315:Oocyte Retrieval; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use*; D027724:Reproductive Techniques, Assisted; D029589:Seminal Plasma Proteins / Q000032:analysis*; D013076:Sperm Count; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; D029589:Seminal Plasma Proteins; D054304:Anti-Mullerian Hormone
keywords: anti-Müllerian hormone; assisted reproduction; male idiopathic infertility; recombinant follicle-stimulating hormone