title: Effect of Admission Glasgow Coma Scale Motor Score on Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Receiving Therapeutic Hypothermia.
abstract: BACKGROUND
  Because the initial (on admission) Glasgow Coma Scale (GCS) examination has not been fully evaluated in comatose survivors of cardiac arrest (CA) who receive therapeutic hypothermia (TH), the aim of the present study was to determine any association between the admission GCS motor score and neurologic outcomes in patients with out-of-hospital CA who receive TH.
  
  
  RESULTS
  In the J-PULSE-HYPO study registry, patients with bystander-witnessed CA were eligible for inclusion. Patients were divided into 3 groups based on GCS motor score (1, 2-3, and 4-5) to assess various effects on neurologic outcome. Univariate and multivariate analyses were performed to identify independent predictors of good neurologic outcome at 90 days. Of 452 patients, 302 were enrolled. There was a significant difference among the 3 patient groups with regard to neurologic outcome at 90 days in the univariate analysis. Multiple logistic regression analyses showed that the GCS motor score on admission, age >65 years, bystander cardiopulmonary resuscitation, the time from collapse to return of spontaneous circulation, and pupil size <4 mm were independent predictors of a good neurologic outcome at 90 days in cases of CA (GCS motor score, 4-5: odds ratio, 8.18; 95% confidence interval: 1.90-60.28; P<0.01).
  
  
  CONCLUSIONS
  GCS motor score is an independent predictor of good neurologic outcome at 90 days in patients sustaining out-of-hospital CA who receive TH.
authors.affiliation: Emergency Medical Center, Kagawa University Hospital.
authors.forename: Toru
authors.initials: T
authors.lastname: Hifumi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Kenya
authors.initials: K
authors.lastname: Kawakita
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Sawano
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tahara
authors.forename: Mamoru
authors.initials: M
authors.lastname: Hase
authors.forename: Kenji
authors.initials: K
authors.lastname: Nishioka
authors.forename: Shinichi
authors.initials: S
authors.lastname: Shirai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hazui
authors.forename: Hideki
authors.initials: H
authors.lastname: Arimoto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kashiwase
authors.forename: Shunji
authors.initials: S
authors.lastname: Kasaoka
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Motomura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yasuga
authors.forename: Naohiro
authors.initials: N
authors.lastname: Yonemoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Ken
authors.initials: K
authors.lastname: Nagao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nonogi
mesh_terms: D000368:Aged; D003128:Coma / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D012042:Registries