title: Role of regulatory T-cells during hepatitis C infection: From the acute phase to post-transplantation recurrence.
abstract: Hepatitis C viral infection persists and becomes chronic in a majority of affected individuals. Numerous factors have been described to explain how the virus manages to escape the host immune system. One important escape mechanism is the increase in regulatory T cells induced by the virus. In this review, we will focus on the status of regulatory T cells throughout the natural history of hepatitis C infection and after liver transplantation. The molecular mechanisms involved in increasing the number of regulatory T cells are also discussed, as are data regarding the impact of regulatory T-cells on hepatic fibrosis in the context of hepatitis C viral infection.
authors.affiliation: Sorbonne University, UPMC Univ. Paris 6, Inserm UMRS 938, CDR Saint-Antoine, Paris, France. Electronic address: clement.barjon@inserm.fr.
authors.forename: Clément
authors.initials: C
authors.lastname: Barjon
authors.affiliation: Sorbonne University, UPMC Univ. Paris 6, Inserm UMRS 938, CDR Saint-Antoine, Paris, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Dahlqvist
authors.affiliation: Sorbonne University, UPMC Univ. Paris 6, Inserm UMRS 938, CDR Saint-Antoine, Paris, France; Department of Hepatology and Gastroenterology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Yvon
authors.initials: Y
authors.lastname: Calmus
authors.affiliation: Sorbonne University, UPMC Univ. Paris 6, Inserm UMRS 938, CDR Saint-Antoine, Paris, France; Department of Hepatology and Gastroenterology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Filomena
authors.initials: F
authors.lastname: Conti
mesh_terms: D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000276:immunology*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000276:immunology*; D016031:Liver Transplantation; D011183:Postoperative Complications / Q000276:immunology*; D012008:Recurrence; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
keywords: Hepatitis C virus; Regulatory T-cells; Transplantation