title: X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.
abstract: Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China).
authors.forename: Wenpei
authors.initials: W
authors.lastname: Fan
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China). wbbu@mail.sic.ac.cn.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Bu
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai, 200032 (P.R. China).
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Institute of Radiation Medicine, Fudan University, Shanghai, 200032 (P.R. China).
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai, 200032 (P.R. China).
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China).
authors.forename: Qianjun
authors.initials: Q
authors.lastname: He
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China).
authors.forename: Dalong
authors.initials: D
authors.lastname: Ni
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China).
authors.forename: Zhaowen
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai, 200032 (P.R. China).
authors.forename: Kuaile
authors.initials: K
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Neuroscience, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031 (P.R. China).
authors.forename: Jiwen
authors.initials: J
authors.lastname: Bu
authors.affiliation: State Key Laboratory of Neuroscience, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031 (P.R. China).
authors.forename: Jiulin
authors.initials: J
authors.lastname: Du
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China).
authors.forename: Jianan
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China). jlshi@mail.sic.ac.cn.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects*; D009569:Nitric Oxide / Q000737:chemistry*; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014965:X-Rays
chemical_list: D009569:Nitric Oxide
keywords: NO release; X-ray radiation; hypoxic radiosensitization; luminescent imaging; on-demand therapy