title: Bioprinting for cancer research.
abstract: Bioprinting offers the ability to create highly complex 3D architectures with living cells. This cutting-edge technique has significantly gained popularity and applicability in several fields. Bioprinting methods have been developed to effectively and rapidly pattern living cells, biological macromolecules, and biomaterials. These technologies hold great potential for applications in cancer research. Bioprinted cancer models represent a significant improvement over previous 2D models by mimicking 3D complexity and facilitating physiologically relevant cell-cell and cell-matrix interactions. Here we review bioprinting methods based on inkjet, microextrusion, and laser technologies and compare 3D cancer models with 2D cancer models. We discuss bioprinted models that mimic the tumor microenvironment, providing a platform for deeper understanding of cancer pathology, anticancer drug screening, and cancer treatment development.
authors.affiliation: Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Road, Storrs, CT 06269, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Knowlton
authors.affiliation: Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Road, Storrs, CT 06269, USA.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Onal
authors.affiliation: Department of Mechanical Engineering, University of Connecticut, 191 Auditorium Road, Storrs, CT 06269, USA.
authors.forename: Chu Hsiang
authors.initials: CH
authors.lastname: Yu
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Jean J
authors.initials: JJ
authors.lastname: Zhao
authors.affiliation: Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Road, Storrs, CT 06269, USA; Department of Mechanical Engineering, University of Connecticut, 191 Auditorium Road, Storrs, CT 06269, USA. Electronic address: savas@engr.uconn.edu.
authors.forename: Savas
authors.initials: S
authors.lastname: Tasoglu
mesh_terms: D035843:Biomedical Research; D062028:Bioprinting; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms