title: Unexpected Anemia and Reticulocytopenia in an Adolescent With Sickle Cell Anemia Receiving Chronic Transfusion Therapy.
abstract: In a patient with sickle cell disease receiving chronic transfusion, exacerbation of anemia with reticulocytopenia must prompt consideration of a delayed hemolytic transfusion reaction with hyperhemolysis, as further transfusion may worsen this condition; definitive diagnosis is sometimes difficult. Anemia evolving during parvovirus B19-induced erythroid hypoplasia (transient aplastic crisis) should be attenuated in chronic transfusion patients due to superior survival of transfused over endogenous red blood cells. A 16-year-old with sickle cell disease receiving chronic transfusion of modified intensity (goal to maintain hemoglobin S<50%) who developed symptomatic anemia with reticulocytopenia was later shown to have had transient aplastic crisis.
authors.affiliation: State University of New York-Downstate Medical Center, *College of Medicine †Department of Pediatrics, Division of Hematology/Oncology, Brooklyn, NY.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Blauel
authors.forename: Lily T
authors.initials: LT
authors.lastname: Grossmann
authors.forename: Madhav
authors.initials: M
authors.lastname: Vissa
authors.forename: Scott T
authors.initials: ST
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000209:etiology*; D000755:Anemia, Sickle Cell / Q000628:therapy*; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017701:Reticulocyte Count; D012156:Reticulocytes / Q000473:pathology*; D065227:Transfusion Reaction / Q000209:etiology* / Q000473:pathology