title: Molecular control of stress transmission in the microtubule cytoskeleton.
abstract: In this article, we will summarize recent progress in understanding the mechanical origins of rigidity, strength, resiliency and stress transmission in the MT cytoskeleton using reconstituted networks formed from purified components. We focus on the role of network architecture, crosslinker compliance and dynamics, and molecular determinants of single filament elasticity, while highlighting open questions and future directions for this work.
authors.affiliation: Department of Mechanical Engineering and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106-5070, USA.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Lopez
authors.affiliation: Department of Mechanical Engineering and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106-5070, USA. Electronic address: valentine@engineering.ucsb.edu.
authors.forename: Megan T
authors.initials: MT
authors.lastname: Valentine
mesh_terms: D000818:Animals; D004548:Elasticity; D008870:Microtubules / Q000737:chemistry*; D013314:Stress, Mechanical
keywords: Elasticity; Microtubule-associated protein; Microtubules; Rheology