title: Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics.
abstract: Lipopeptides based on the intracellular loops of cell-surface receptors, known as "Pepducins," represent a promising new class of compounds used for the study of membrane proteins and as potential therapeutics in a variety of diseases. Detailed knowledge of the three-dimensional structure of G-protein-coupled receptors (GPCRs) and delineation of the mechanisms of pepducin activation and biased G-protein signaling has facilitated the development of even more potent pepducin allosteric modulators.
authors.affiliation: Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Tufts University School of Medicine, Box 7510, 800 Washington Street, Boston, MA, 02111, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Lidija
authors.initials: L
authors.lastname: Covic
authors.forename: Athan
authors.initials: A
authors.lastname: Kuliopulos
mesh_terms: D000494:Allosteric Regulation; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D055666:Lipopeptides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D055666:Lipopeptides; D043562:Receptors, G-Protein-Coupled