title: First Iridium-Catalyzed Highly Enantioselective Hydrogenation of β-Nitroacrylates.
abstract: The first highly chemo- and enantioselective hydrogenation of β-nitroacrylates was accomplished with an iridium catalyst (Ir-4) with yields and enantioselectivities of up to 96% and 98% ee, respectively. The resulting α-chiral β-nitro propionates are attractive building blocks for the synthesis of chiral β(2)-amino acids, which are the core scaffolds of bioactive natural products, pharmaceuticals, and β-peptides.
authors.affiliation: †Department of Pesticide Science, College of Plant Protection, Nanjing Agricultural University, Weigang 1, Xuanwu District, Nanjing 210095, P.R. China.
authors.forename: Shengkun
authors.initials: S
authors.lastname: Li
authors.affiliation: †Department of Pesticide Science, College of Plant Protection, Nanjing Agricultural University, Weigang 1, Xuanwu District, Nanjing 210095, P.R. China.
authors.forename: Taifeng
authors.initials: T
authors.lastname: Xiao
authors.affiliation: †Department of Pesticide Science, College of Plant Protection, Nanjing Agricultural University, Weigang 1, Xuanwu District, Nanjing 210095, P.R. China.
authors.forename: Dangdang
authors.initials: D
authors.lastname: Li
authors.affiliation: ‡Department of Chemistry and Chemical Biology and Department of Pharmaceutical Chemistry, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D000596:Amino Acids; D009574:Nitro Compounds; D007495:Iridium