title: Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes.
abstract: Understanding the interactions between miRNAs and genes they regulate during the acute phase response is crucial to our understanding of inflammatory diseases and processes. Inducing the acute phase response in hepatocytes by stimulating them with interleukin-6 [1] and then examining global changes in mRNA and miRNA expression can provide insight into the timing and dynamics of these interactions. Here we provide additional data for our study, Ref. [2]. In this data, we identify and validate IL-6-induced changes in gene expression [3-6] and their functional relationships over time and between cell types by gene ontology [7,8]. We also provide data showing the enrichment of miRNA binding motifs in the 3׳UTRs of differentially expressed genes [9], and their predicted gene targets derived from our RNA-seq data [10].
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland ; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland.
authors.forename: Samuel W
authors.initials: SW
authors.lastname: Lukowski
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland ; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Fish
authors.affiliation: Department of Cell Physiology and Metabolism, University of Geneva Medical Center, Geneva, Switzerland.
authors.forename: Juliette
authors.initials: J
authors.lastname: Martin-Levilain
authors.affiliation: Surgical Research Unit, Department of Surgery, University Hospital, 1211 Geneva, Switzerland.
authors.forename: Carmen
authors.initials: C
authors.lastname: Gonelle-Gispert
authors.affiliation: Surgical Research Unit, Department of Surgery, University Hospital, 1211 Geneva, Switzerland.
authors.forename: Leo H
authors.initials: LH
authors.lastname: Bühler
authors.affiliation: Department of Cell Physiology and Metabolism, University of Geneva Medical Center, Geneva, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Maechler
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland ; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland ; Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland.
authors.forename: Emmanouil T
authors.initials: ET
authors.lastname: Dermitzakis
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland ; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland.
authors.forename: Marguerite
authors.initials: M
authors.lastname: Neerman-Arbez