title: Molecular Factors of Cytokine-Dependent Activation of T Cells in Pulmonary Tuberculosis.
abstract: The parameters characterizing antituberculous immune response at the stage of cytokinedependent activation of T cells were analyzed in 90 patients with pulmonary tuberculosis before etiotropic therapy. Immunophenotyping of T cells for IL-12Rβ2, WSX-1, and gp130 surface markers and T-bet intracellular transcription factor was carried out after specific IL-12/IL-27 induction of cells in vitro. An increase in the counts of CD3(+)T-bet(+), CD3(+)IL-12Rβ2 (+), and CD3(+)WSX-1(+)gp130(+) cells and the level of T cells with high expression of WSX-1 inhibitory molecule (CD3(+)WSX-1(hi+)gp130(-) and CD3(+)WSX-1(hi+)gp130(+)) was detected. The type of disorders in the inductive stage of antituberculous immune response did not depend on the clinical form of disease.
authors.affiliation: Siberian State Medical University, Tomsk, Russia, orevi@mail.ru.
authors.forename: I E
authors.initials: IE
authors.lastname: Esimova
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: M S
authors.initials: MS
authors.lastname: Ignatova
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskii
authors.forename: Yu V
authors.initials: YV
authors.lastname: Kolobovnikova
mesh_terms: D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007378:Interleukins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000378:metabolism*; D055815:Young Adult
chemical_list: D016207:Cytokines; D007378:Interleukins