title: Dynamical Regulation Analysis Identifies Molecular Mechanisms of Fuzheng-Huayu Formula against Hepatitis B-Caused Liver Cirrhosis.
abstract: Fuzheng-Huayu (FZHY) tablet was formulated based on Chinese medicine theory in treating liver fibrosis. A clinical trial has indicated that FZHY can against hepatitis B-caused liver cirrhosis (HBC), but the underlying mechanism of FZHY efficacy is unclear. Here, we report that miRNA expression levels are remarkably changed when FZHY formula was used in HBC patient's treatment as a paradigm of trials. Then, we functionally characterize the significant impact of potential kernel miRNAs by miRNA-target network analysis. Enrichment analysis show that the FZHY formula dramatically effecting the molecular regulated module in HBC. Thus, we infer that FZHY plays a critical function in HBC treatment process and directly regulated many important pathways, including but not limited to cell cycle, p53 signaling pathway, and TGF-β signaling pathway, suggesting a new strategy for investigating the molecular mechanism of FZHY treatment.
authors.affiliation: Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Qi-Long
authors.initials: QL
authors.lastname: Chen
authors.affiliation: Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Yi-Yu
authors.initials: YY
authors.lastname: Lu
authors.affiliation: Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Peng
authors.affiliation: Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Dong
authors.affiliation: Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wei
authors.affiliation: Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Song
authors.affiliation: Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Qian-Mei
authors.initials: QM
authors.lastname: Zhou
authors.affiliation: Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Shi-Bing
authors.initials: SB
authors.lastname: Su