title: The somatotropic axis and longevity in mice.
abstract: The somatotropic signaling pathway has been implicated in aging and longevity studies in mice and other species. The physiology and lifespans of a variety of mutant mice, both spontaneous and genetically engineered, have contributed to our current understanding of the role of growth hormone and insulin-like growth factor I on aging-related processes. Several other mice discovered to live longer than their wild-type control counterparts also exhibit differences in growth factor levels; however, the complex nature of the phenotypic changes in these animals may also impact lifespan. The somatotropic axis impacts several pathways that dictate insulin sensitivity, nutrient sensing, mitochondrial function, and stress resistance as well as others that are thought to be involved in lifespan regulation.
authors.affiliation: Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, North Dakota holly.brown.borg@med.und.edu.
authors.forename: H M
authors.initials: HM
authors.lastname: Brown-Borg
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D005346:Fibroblast Growth Factors / Q000502:physiology; D013006:Growth Hormone / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D010908:Pituitary Hormones, Anterior / Q000502:physiology; D017451:Receptors, Somatomedin / Q000502:physiology; D015398:Signal Transduction
chemical_list: D010908:Pituitary Hormones, Anterior; D017451:Receptors, Somatomedin; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: aging; growth hormone; insulin-like growth factor; lifespan regulation