title: Dopamine D1 and opioid receptor antagonists differentially reduce the acquisition and expression of fructose-conditioned flavor preferences in BALB/c and SWR mice.
abstract: Sugar appetite is influenced by unlearned and learned preferences in rodents. The present study examined whether dopamine (DA) D1 (SCH23390: SCH) and opioid (naltrexone: NTX) receptor antagonists differentially altered the expression and acquisition of fructose-conditioned flavor preferences (CFPs) in BALB/c and SWR mice. In expression experiments, food-restricted mice alternately (10 sessions, 1h) consumed a flavored (e.g., cherry) 8% fructose+0.2% saccharin solution (CS+) and a differently-flavored (e.g., grape) 0.2% saccharin solution (CS-). Two-bottle CS choice tests (1h) occurred 0.5h following vehicle: SCH (200 or 800 nmol/kg) or NTX (1 or 5mg/kg). SCH, but not NTX significantly reduced CS+ preference in both strains. In acquisition experiments, 0.5h prior to 10 acquisition training sessions, vehicle, SCH (50 nmol/kg), NTX (1 mg/kg) or Limited Control vehicle treatments were administered, followed by two-bottle CS choice tests without injections. SCH and NTX reduced training intakes in both strains. BALB/c mice displayed hastened extinction of the fructose-CFP following training with SCH, but not NTX. SCH eliminated fructose-CFP acquisition in SWR mice, whereas NTX hastened extinction of the CFP. These results are compared to previous drug findings obtained with sucrose-CFPs in SWR and BALB/c mice, and are discussed in terms of differential effects of these sugars on oral and post-oral conditioning.
authors.affiliation: Behavioral and Cognitive Neuroscience Cluster of the Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, USA.
authors.forename: Tamar T
authors.initials: TT
authors.lastname: Kraft
authors.affiliation: Department of Psychology, Queens College, City University of New York, New York, NY, USA.
authors.forename: Yakov
authors.initials: Y
authors.lastname: Yakubov
authors.affiliation: Department of Psychology, Queens College, City University of New York, New York, NY, USA.
authors.forename: Donald
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Psychology, Queens College, City University of New York, New York, NY, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Fitzgerald
authors.affiliation: Department of Psychology, Queens College, City University of New York, New York, NY, USA.
authors.forename: Elona
authors.initials: E
authors.lastname: Natanova
authors.affiliation: Behavioral and Cognitive Neuroscience Cluster of the Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, USA; Department of Psychology, Brooklyn College, City University of New York, New York, NY, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Sclafani
authors.affiliation: Behavioral and Cognitive Neuroscience Cluster of the Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, USA; Department of Psychology, Queens College, City University of New York, New York, NY, USA. Electronic address: richard.bodnar@qc.cuny.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Bodnar
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D002755:Choice Behavior / Q000187:drug effects / Q000502:physiology; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology; D005508:Food Deprivation; D005518:Food Preferences / Q000187:drug effects* / Q000502:physiology; D005632:Fructose; D008297:Male; D008807:Mice, Inbred BALB C; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013045:Species Specificity
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; C583261:Drd1 protein, mouse; D009292:Narcotic Antagonists; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D005632:Fructose; D009271:Naltrexone
keywords: Genetic variance; Naltrexone; Orosensory (flavor–flavor) learning; SCH23390