title: Evaluation of rigid registration methods for whole head imaging in diffuse optical tomography.
abstract: Functional brain imaging has become an important neuroimaging technique for the study of brain organization and development. Compared to other imaging techniques, diffuse optical tomography (DOT) is a portable and low-cost technique that can be applied to infants and hospitalized patients using an atlas-based light model. For DOT imaging, the accuracy of the forward model has a direct effect on the resulting recovered brain function within a field of view and so the accuracy of the spatially normalized atlas-based forward models must be evaluated. Herein, the accuracy of atlas-based DOT is evaluated on models that are spatially normalized via a number of different rigid registration methods on 24 subjects. A multileveled approach is developed to evaluate the correlation of the geometrical and sensitivity accuracies across the full field of view as well as within specific functional subregions. Results demonstrate that different registration methods are optimal for recovery of different sets of functional brain regions. However, the "nearest point to point" registration method, based on the EEG 19 landmark system, is shown to be the most appropriate registration method for image quality throughout the field of view of the high-density cap that covers the whole of the optically accessible cortex.
authors.affiliation: University of Birmingham , School of Computer Science, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: Xue
authors.initials: X
authors.lastname: Wu
authors.affiliation: Washington University School of Medicine , Department of Radiology, 4525 Scott Avenue, St. Louis, Missouri 63110, United States.
authors.forename: Adam T
authors.initials: AT
authors.lastname: Eggebrecht
authors.affiliation: Fetal-Neonatal Neuroimaging and Developmental Science Center , Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
authors.forename: Silvina L
authors.initials: SL
authors.lastname: Ferradal
authors.affiliation: Washington University School of Medicine , Department of Radiology, 4525 Scott Avenue, St. Louis, Missouri 63110, United States ; Washington University , Department of Biomedical Engineering, One Brookings Drive, St. Louis, Missouri 63130, United States.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Culver
authors.affiliation: University of Birmingham , School of Computer Science, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: Hamid
authors.initials: H
authors.lastname: Dehghani
keywords: atlas-based tomography; diffuse optical tomography; functional connectivity brain imaging; registration; sensitivity analyses; whole head imaging