title: A role for chromatin topology in imprinted domain regulation.
abstract: Recently, many advancements in genome-wide chromatin topology and nuclear architecture have unveiled the complex and hidden world of the nucleus, where chromatin is organized into discrete neighbourhoods with coordinated gene expression. This includes the active and inactive X chromosomes. Using X chromosome inactivation as a working model, we utilized publicly available datasets together with a literature review to gain insight into topologically associated domains, lamin-associated domains, nucleolar-associating domains, scaffold/matrix attachment regions, and nucleoporin-associated chromatin and their role in regulating monoallelic expression. Furthermore, we comprehensively review for the first time the role of chromatin topology and nuclear architecture in the regulation of genomic imprinting. We propose that chromatin topology and nuclear architecture are important regulatory mechanisms for directing gene expression within imprinted domains. Furthermore, we predict that dynamic changes in chromatin topology and nuclear architecture play roles in tissue-specific imprint domain regulation during early development and differentiation.
authors.affiliation: a Departments of Obstetrics & Gynecology, and Biochemistry, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.|b Children's Health Research Institute, 4th Floor, Victoria Research Laboratories, A4-130a, 800 Commissioners Rd E, London, ON N6C 2V5, Canada.
authors.forename: William A
authors.initials: WA
authors.lastname: MacDonald
authors.affiliation: a Departments of Obstetrics & Gynecology, and Biochemistry, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.|b Children's Health Research Institute, 4th Floor, Victoria Research Laboratories, A4-130a, 800 Commissioners Rd E, London, ON N6C 2V5, Canada.
authors.forename: Saqib S
authors.initials: SS
authors.lastname: Sachani
authors.affiliation: a Departments of Obstetrics & Gynecology, and Biochemistry, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.|b Children's Health Research Institute, 4th Floor, Victoria Research Laboratories, A4-130a, 800 Commissioners Rd E, London, ON N6C 2V5, Canada.
authors.forename: Carlee R
authors.initials: CR
authors.lastname: White
authors.affiliation: a Departments of Obstetrics & Gynecology, and Biochemistry, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.|b Children's Health Research Institute, 4th Floor, Victoria Research Laboratories, A4-130a, 800 Commissioners Rd E, London, ON N6C 2V5, Canada.
authors.forename: Mellissa R W
authors.initials: MR
authors.lastname: Mann
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000737:chemistry* / Q000378:metabolism; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism; D018392:Genomic Imprinting; D006801:Humans; D051379:Mice; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000737:chemistry / Q000378:metabolism; D049951:X Chromosome Inactivation
chemical_list: D002843:Chromatin; D028861:Nuclear Pore Complex Proteins; D062085:RNA, Long Noncoding
keywords: ARN long non codant; X chromosome inactivation; architecture nucléaire; chromatin topology; empreinte génomique; genomic imprinting; inactivation du chromosome X; long noncoding RNA; nuclear architecture; topologie de la chromatine