title: Engineering the defect state and reducibility of ceria based nanoparticles for improved anti-oxidation performance.
abstract: Due to their excellent anti-oxidation performance, CeO2 nanoparticles receive wide attention in pharmacological application. Deep understanding of the anti-oxidation mechanism of CeO2 nanoparticles is extremely important to develop potent CeO2 nanomaterials for anti-oxidation application. Here, we report a detailed study on the anti-oxidation process of CeO2 nanoparticles. The valence state and coordination structure of Ce are characterized before and after the addition of H2O2 to understand the anti-oxidation mechanism of CeO2 nanoparticles. Adsorbed peroxide species are detected during the anti-oxidation process, which are responsible for the red-shifted UV-vis absorption spectra of CeO2 nanoparticles. Furthermore, the coordination number of Ce in the first coordination shell slightly increased after the addition of H2O2. On the basis of these experimental results, the reactivity of coordination sites for peroxide species is considered to play a key role in the anti-oxidation performance of CeO2 nanoparticles. Furthermore, we present a robust method to engineer the anti-oxidation performance of CeO2 nanoparticles through the modification of the defect state and reducibility by doping with Gd(3+). Improved anti-oxidation performance is also observed in cell culture, where the biocompatible CeO2-based nanoparticles can protect INS-1 cells from oxidative stress induced by H2O2, suggesting the potential application of CeO2 nanoparticles in the treatment of diabetes.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. sun@pku.edu.cn yan@pku.edu.cn.
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Dong
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Lyu
authors.forename: Huai-Yuan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Ke
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Kang
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Teng
authors.forename: Ling-Dong
authors.initials: LD
authors.lastname: Sun
authors.forename: Rui
authors.initials: R
authors.lastname: Si
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Zhang
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Huang
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Yan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002563:Cerium / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000633:toxicity; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D056951:Photoelectron Spectroscopy; D051381:Rats; D017382:Reactive Oxygen Species / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D056928:X-Ray Absorption Spectroscopy
chemical_list: D001672:Biocompatible Materials; D056831:Coordination Complexes; D017382:Reactive Oxygen Species; D002563:Cerium; C030583:ceric oxide; D005682:Gadolinium; D006861:Hydrogen Peroxide