title: New phenolic compounds from the seeds of Nigella glandulifera and their inhibitory activities against human cancer cells.
abstract: Four phenolic compounds, including two new ones, Nigephenol A and B (1-2), and a new natural product, Nigephenol C (3), were isolated from the seeds of Nigella glandulifera. Their structures were elucidated on the basis of spectroscopic analyses using HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated by MTT method for in vitro cytotoxicity against four human cancer cell lines (Bel7402, HepG2, HCT-8 and A549). The results revealed that Compounds 1-4 showed more selective activities against HepG2 cells, and that Compound 2 showed significant inhibitory effects against four human tumor cell lines with IC50 values comparable to those of 5-fluorouracil.
authors.affiliation: Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address: coumarin1968@hotmail.com.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Liu
authors.affiliation: Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Bao-Quan
authors.initials: BQ
authors.lastname: Chen
authors.affiliation: Xinjiang Institute of Materia Medica, Ürümuqi 830001, PR China.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D031844:Nigella / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010636:Phenols
keywords: Cytotoxic activity; Nigella; Nigella glandulifera; Phenolic compounds; Ranunculaceae