title: B-cell receptor signaling in the pathogenesis of lymphoid malignancies.
abstract: B-cell receptor (BCR) signaling pathway plays a central role in B-lymphocyte development and initiation of humoral immunity. Recently, BCR signaling pathway has been shown as a major driver in the pathogenesis of B-cell malignancies. As a result, a vast array of BCR-associated kinases has emerged as rational therapeutic targets changing treatment paradigms in B cell malignancies. Based on high efficacy in early-stage clinical trials, there is rapid clinical development of inhibitors targeting BCR signaling pathway. Here, we describe the essential components of BCR signaling, their function in normal and pathogenic signaling and molecular effects of their inhibition in vitro and in vivo.
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Zwirki I Wigury 61, 02-091 Warsaw, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Bojarczuk
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Zwirki I Wigury 61, 02-091 Warsaw, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Bobrowicz
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Zwirki I Wigury 61, 02-091 Warsaw, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Dwojak
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
authors.forename: Nina
authors.initials: N
authors.lastname: Miazek
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Zapala
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
authors.forename: Anders
authors.initials: A
authors.lastname: Bunes
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Zwirki I Wigury 61, 02-091 Warsaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Siernicka
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Rozanska
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland. Electronic address: magdalena.winiarska@wum.edu.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Winiarska
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D006801:Humans; D007945:Leukemia, Lymphoid / Q000209:etiology* / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D011947:Receptors, Antigen, B-Cell; C400186:STAP1 protein, human
keywords: B-cell receptor; Chronic lymphocytic leukemia; Lymphoma; Signaling