title: The role of interpersonal processes in shaping inflammatory responses to social-evaluative threat.
abstract: In response to social-evaluative threat induced in the laboratory, lower (compared to higher) subjective social class of a participant predicts greater increases in the inflammatory cytokine interleukin-6 (IL-6). In spite of the interpersonal nature of social-evaluation, little work has explored whether characteristics of the evaluator shape physiological responses in this context. In the current study, in a sample of 190 college students (male=66), we explored whether one's subjective social class interacts with the perceived social class of an evaluator to predict changes in Oral Mucosal Transudate (OMT) IL-6 in response to the Trier Social Stress Test (TSST). Participants were randomly assigned to be the speaker or the evaluator. Extending past work, we found that while speakers low in subjective social class consistently respond with strong increases in IL-6 regardless of their perception of their evaluator's social class, speakers high in subjective social class responded with greater increases in IL-6 when their evaluator was perceived as high social class compared to when they were perceived as low social class. This finding highlights the importance of perceptions of the evaluator in informing inflammatory responses to a social-evaluative task.
authors.affiliation: Department of Psychology, University of Pittsburgh, United States. Electronic address: neha.jh@pitt.edu.
authors.forename: Neha A
authors.initials: NA
authors.lastname: John-Henderson
authors.affiliation: Department of Psychology, University of Toronto, Canada.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Stellar
authors.affiliation: Department of Psychology, University of California, Berkeley, United States.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Mendoza-Denton
authors.affiliation: School of Public Health, University of California, Berkeley, United States.
authors.forename: Darlene D
authors.initials: DD
authors.lastname: Francis
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology / Q000523:psychology*; D015850:Interleukin-6 / Q000378:metabolism*; D007398:Interpersonal Relations; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism; D011897:Random Allocation; D012923:Social Class; D012938:Social Perception; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Acute psychological stress; Interleukin-6; Social-evaluation; Subjective social class