title: Curcumin-guided nanotherapy: a lipid-based nanomedicine for targeted drug delivery in breast cancer therapy.
abstract: BACKGROUND
  Delivery of anti-cancer drugs into the cancer cells or tissues by multifunctional nanocarriers may provide a new paradigm in cancer treatment. In this study, folate (FA) decorated nanostructured lipid carriers (NLCs) were constructed as nanomedicine for the delivery of curcumin (CUR).
  
  
  METHODS
  CUR-loaded NLCs (CUR-NLCs) were prepared. FA containing polyethylene glycol (PEG)-distearoylphosphatidylethanolamine (DSPE) (FA-PEG-DSPE) was synthesized and used for the decoration of CUR-NLCs. Their particle size, zeta potential, and drug encapsulation efficiency (EE) were evaluated. In vitro cytotoxicity study FA decorated CUR-NLCs (FA-CUR-NLCs) was tested in MCF-7 human breast cancer cells (MCF-7 cells). In vivo anti-tumor efficacies of the carriers were evaluated on mice bearing breast cancer model.
  
  
  RESULTS
  The optimum FA-CUR-NLCs formulations with the particle size of 127 nm and with a +13 mV surface charge. The growth of MCF-7 cells in vitro was obviously inhibited. FA-CUR-NLCs also displayed the best anti-tumor activity than other formulations in vivo.
  
  
  CONCLUSIONS
  The results demonstrated that FA-CUR-NLCs were efficient in selective delivery to cancer cells over-expressing FA receptors (FRs). Also FA-CUR-NLCs transfer CUR to the breast cancer cells, enhance the anti-tumor capacity. Thus, FA-CUR-NLCs could prove to be a superior nanomedicine to achieve tumor therapeutic efficacy.
authors.affiliation: a Department of Breast Surgery and.
authors.forename: Mingzhen
authors.initials: M
authors.lastname: Lin
authors.affiliation: b Department of Infectious Disease , Weifang People's Hospital , Weifang , China.
authors.forename: Lili
authors.initials: L
authors.lastname: Teng
authors.affiliation: a Department of Breast Surgery and.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Department of Breast Surgery and.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Department of Breast Surgery and.
authors.forename: Xianglian
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000008:administration & dosage* / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D061986:MCF-7 Cells; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008055:Lipids; D010714:Phosphatidylethanolamines; C107570:polyethylene glycol-distearoylphosphatidylethanolamine; D011092:Polyethylene Glycols; D005492:Folic Acid; D003474:Curcumin
keywords: Breast cancer; lipid based nanomedicine; nanostructured lipid carriers; nanotherapy; targeted drug delivery system