title: Weight change after 20 years of age and the incidence of dyslipidemia: a cohort study of Japanese male workers.
abstract: While heavier weight is known to increase the incidence of dyslipidemia, limited data are available on the relationship between weight gain and its development.
  
  
  
  A total of 2647 males were categorized into the following four groups according to the difference between their self-reported weight at 20 years of age and their measured weight in 1994-95: a loss of ≥5% (decrease), loss of <5% or gain of <5% (no change), gain of ≥5 to <15% (increase) and gain of ≥15% (sizable increase). They were followed up until their 2002-03 health examination. Using the 'no change' group as reference, the multivariable-adjusted odds ratio (adjusted for age, body mass index at 20 years of age, physical activity, smoking and alcohol intake) and 95% confidence interval (95% CI) for the incidence of dyslipidemia were determined using logistic regression models.
  
  
  
  A total of 1342 participants developed dyslipidemia during the follow-up period. The 'increase' and 'sizable increase' groups had odds ratios for the incidence of dyslipidemia of 1.97 (95% CI, 1.59-2.45) and 2.68 (2.15-3.34), respectively, demonstrating that there was a significant dose-response association between weight gain since 20 years of age and the incidence of dyslipidemia (P < 0.001 for trend).
  
  
  
  These results suggest that dyslipidemia could be prevented by avoiding weight gain in adulthood.
authors.affiliation: Department of Health and Nutrition Sciences, Faculty of Human Health, Komazawa Women's University, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sogabe
authors.affiliation: Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: S S
authors.initials: SS
authors.lastname: Sawada
authors.affiliation: Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors.forename: I-M
authors.initials: IM
authors.lastname: Lee
authors.affiliation: Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan Graduate School of Sport Sciences, Waseda University, Saitama, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Kawakami
authors.affiliation: Department of Nutritional Education, National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa-Takata
authors.affiliation: Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakata
authors.affiliation: Department of Safety and Health, Tokyo Gas Co. Ltd., Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mitomi
authors.affiliation: Department of Safety and Health, Tokyo Gas Co. Ltd., Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Noguchi
authors.affiliation: Department of Safety and Health, Tokyo Gas Co. Ltd., Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsukamoto
authors.affiliation: Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyachi
authors.affiliation: Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
authors.forename: S N
authors.initials: SN
authors.lastname: Blair
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D001835:Body Weight; D015331:Cohort Studies; D050171:Dyslipidemias / Q000453:epidemiology*; D015444:Exercise; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires; D015430:Weight Gain; D015431:Weight Loss; D055815:Young Adult
keywords: dyslipidemia; early adulthood; health examination; obesity; weight gain