title: Findings at brain MRI in children with dengue fever and neurological symptoms.
abstract: Dengue is a flavivirus of the genus arbovirus with four serotypes, from DEN 1 to DEN 4. There has been an increase in incidence of dengue infection in children in the tropics and subtropics. Dengue has a variable clinical presentation, with many patients being asymptomatic. Its clinical manifestations in children vary from fever and arthralgia to life-threatening dengue hemorrhagic fever and dengue shock syndrome. We describe MRI findings in children with neurological involvement including dengue encephalopathy, acute hypoxic injury and dengue encephalitis. Dengue encephalopathy is usually secondary to multisystem derangement such as shock, hepatitis, coagulopathy and concurrent bacterial infection and is relatively common. Dengue encephalitis from direct neuronal invasion is rare. Nonspecific changes are seen on brain MRI in dengue infection. Clinical and laboratory findings as well as outcome do not necessarily correspond with brain MRI findings.
authors.affiliation: Department of Radiodiagnosis, Indraprastha Apollo Hospitals, Mathura Road, Sarita Vihar, New Delhi, 110076, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Rastogi
authors.affiliation: Department of Radiodiagnosis, Indraprastha Apollo Hospitals, Mathura Road, Sarita Vihar, New Delhi, 110076, India. bhavya1317@yahoo.co.in.
authors.forename: Bhavya
authors.initials: B
authors.lastname: Garg
mesh_terms: D001921:Brain / Q000473:pathology*; D002648:Child; D003715:Dengue / Q000150:complications / Q000473:pathology*; D003937:Diagnosis, Differential; D018792:Encephalitis, Viral / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009468:Neuromuscular Diseases / Q000209:etiology / Q000473:pathology*
keywords: Brain; Children; Dengue infection; Encephalitis; Encephalopathy; Magnetic resonance imaging