title: Novel Anticoagulants in Atrial Fibrillation: Monitoring, Reversal and Perioperative Management.
abstract: Atrial fibrillation continues to be a significant source of morbidity and mortality worldwide. Effective anticoagulation remains the cornerstone of outpatient and inpatient treatment. The use of the new generation of anticoagulants (NOACs) continues to grow. Recently published data indicate their cost-effectiveness and overall safety in stroke prevention; compared to vitamin K antagonists, they can be prescribed in fixed doses for long-term therapy without the need for coagulation monitoring. Both United States and European Guidelines recommend NOACs for stroke prevention in patients with atrial fibrillation. This review discusses each of the NOACs, along with their efficacy and safety data. It explores the most recent guidelines regarding their perioperative use in atrial fibrillation patients. It also discusses bleeding complications, perioperative management, and reversal agents.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: Fadi
authors.initials: F
authors.lastname: Shamoun
authors.affiliation: Damascus University Faculty of Medicine, Damascus, Syria.
authors.forename: Hiba
authors.initials: H
authors.lastname: Obeid
authors.affiliation: Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic, Phoenix, AZ 85054, USA.
authors.forename: Harish
authors.initials: H
authors.lastname: Ramakrishna
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D016903:Drug Monitoring; D006801:Humans; D019990:Perioperative Care
chemical_list: D000925:Anticoagulants