title: An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin.
abstract: We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China. jzhou@chem.ecnu.edu.cn.
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Liao
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Liu
authors.forename: Jin-Sheng
authors.initials: JS
authors.lastname: Yu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D004987:Ethers / Q000737:chemistry*; D054879:Halogenation; D009682:Magnetic Resonance Spectroscopy; D011799:Quinazolines / Q000737:chemistry*; D012821:Silanes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001688:Biological Products; D004987:Ethers; D011799:Quinazolines; D012821:Silanes; C046243:tryptanthrine; C116609:3-hydroxybutanal