title: Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms.
abstract: Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the biofilms. Moreover, this class of membrane-active molecules disarms the development of bacterial resistance.
authors.affiliation: Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560064, India. jayanta@jncasr.ac.in.
authors.forename: Jiaul
authors.initials: J
authors.lastname: Hoque
authors.forename: Mohini M
authors.initials: MM
authors.lastname: Konai
authors.forename: Sandip
authors.initials: S
authors.lastname: Samaddar
authors.forename: Spandhana
authors.initials: S
authors.lastname: Gonuguntala
authors.forename: Goutham B
authors.initials: GB
authors.lastname: Manjunath
authors.forename: Chandradhish
authors.initials: C
authors.lastname: Ghosh
authors.forename: Jayanta
authors.initials: J
authors.lastname: Haldar
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects*; D004351:Drug Resistance / Q000187:drug effects*; D057809:HEK293 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D054852:Small Molecule Libraries