title: Serum cortisol level and disc displacement disorders of the temporomandibular joint.
abstract: Temporomandibular disorders (TMD) are a significant public health problem, affecting approximately 5-12% of the population.
  
  
  OBJECTIVE
  This retrospective cross-sectional study investigated the relationship between 8 AM serum cortisol levels (8ASC) and disc displacement disorders (DDD) of TMD. One hundred and forty patients with DDD were recruited. Among them, 60 patients comprised the case group of disc displacement without reduction with limited opening (DDWORWLO, age 37·7 ± 17·22), and 80 were 'other DDD' for the control group (age 36·4 ± 13·08). The independent variables included domains of demography, history, malocclusion, comorbid symptoms, comorbid TMD and 8ASC. Data were analysed with the chi-square test, logistic regression and receiver operating characteristic (ROC) curve. Results of multiple logistic regression showed that 8ASC was the only factor significantly related to DDWORWLO (P = 0·006). Receiver operating characteristic analysis of DDWORWLO and 8ASC indicated an area under the curve of 0·669, standard error of 0·049 and P value of 0·001. The adequate cut-off point of 8ASC was 12·45 (μg dL(-1) ), with sensitivity of 0·636, and specificity of 0·729. 8 AM serum cortisol level can be used as a clinical clue to differentiate DDWORWLO from other DDD.
authors.affiliation: Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Tainan, Taiwan.
authors.forename: S-L
authors.initials: SL
authors.lastname: Lin
authors.affiliation: Centre for Environment and Population Health, Griffith University, Brisbane, QLD, Australia.
authors.forename: S-L
authors.initials: SL
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Madou Sin Lau Hospital, Tainan, Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Tsai
authors.affiliation: Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: S-Y
authors.initials: SY
authors.lastname: Ko
authors.affiliation: Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.|Department of Oral and Maxillofacial Surgery, Tainan Sin Lau Hospital, Tainan, Taiwan.
authors.forename: J-W
authors.initials: JW
authors.lastname: Yang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D012372:ROC Curve; D012189:Retrospective Studies; D019224:Temporomandibular Joint Disc / Q000503:physiopathology*; D013705:Temporomandibular Joint Disorders / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D006854:Hydrocortisone
keywords: 8 AM serum cortisol level; disc displacement disorders of temporomandibular joint; disc displacement without reduction with limited opening; temporomandibular disorders