title: Familiarity for famous faces and names is not equally subtended by the right and left temporal poles. Evidence from an rTMS study.
abstract: The aims of the present experiment was to investigate: (a) if transient disruption of neural activity in the right (RTP) or left temporal pole (LTP) can interfere with the development of a familiarity feeling to the presentation of faces/written names of famous/unknown people; and (b) if this interference specifically affects the familiarity for faces after inhibition of the RTP and for names after inhibition of the LTP. Twenty healthy volunteers took part in the study. Repetitive transcranial magnetic stimulation (rTMS) was administered online; it disrupted the neural activity of the right or left TP in concomitance with the presentation of each face and name whose familiarity had to be assessed. Furthermore, in a control group, each participant was submitted to a single experimental session in which rTMS was delivered to the vertex in association with the presentation of faces and written names. Since previous rTMS studies have shown that the temporary inactivation of the right and left TP influences the response latencies, but not the number of correct responses, in this study we took into account both the number of correct responses obtained in different experimental conditions and the corresponding response latencies. A three-way factorial ANOVA carried out on the Response Scores showed only a general effect of the Type of Stimuli, due to better performances on names than on faces. This greater familiarity of names is consistent with previous data reported in the literature. In the three-way factorial ANOVA carried out on the Latency Scores, post-hoc analyses showed an increased latency of responses to faces after right stimulation in Latency Total, Latency on Correct responses and Latency on Unfamiliar faces. None of these results were obtained in the control group. These data suggest that rTMS at the level of the RTP preferentially affects the development of familiarity feelings to the presentation of faces of famous people.
authors.affiliation: Department of Neurology, Campus Bio-Medico University, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ranieri
authors.affiliation: Institute of Neurology and Center for Neuropsychological Research of the Policlinico Gemelli, Catholic University of Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ferraccioli
authors.affiliation: Institute of Neurology and Center for Neuropsychological Research of the Policlinico Gemelli, Catholic University of Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Stampanoni Bassi
authors.affiliation: Department of Neurology, Campus Bio-Medico University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Musumeci
authors.affiliation: Department of Neurology, Campus Bio-Medico University, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Di Lazzaro
authors.affiliation: Institute of Neurology and Center for Neuropsychological Research of the Policlinico Gemelli, Catholic University of Rome, Italy; IRCCS Fondazione Santa Lucia, Department of Clinical and Behavioral Neurology, Rome, Italy. Electronic address: gainotti@rm.unicatt.it.
authors.forename: G
authors.initials: G
authors.lastname: Gainotti
authors.affiliation: Institute of Neurology and Center for Neuropsychological Research of the Policlinico Gemelli, Catholic University of Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Marra
mesh_terms: D000328:Adult; D005145:Face; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D009275:Names; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
keywords: Face and name familiarity feelings; Repetitive transcranial magnetic stimulation; Right and left stimulation; Temporal pole; rTMS