title: Three-dimensional morphology of the human embryonic brain.
abstract: The morphogenesis of the cerebral vesicles and ventricles was visualized in 3D movies using images derived from human embryo specimens between Carnegie stage 13 and 23 from the Kyoto Collection. These images were acquired with a magnetic resonance microscope equipped with a 2.35-T superconducting magnet. Three-dimensional images using the same scale demonstrated brain development and growth effectively. The non-uniform thickness of the brain tissue, which may indicate brain differentiation, was visualized with thickness-based surface color mapping. A closer view was obtained of the unique and complicated differentiation of the rhombencephalon, especially with regard to the internal view and thickening of the brain tissue. The present data contribute to a better understanding of brain and cerebral ventricle development.
authors.affiliation: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shiraishi
authors.affiliation: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Katayama
authors.affiliation: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakashima
authors.affiliation: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan ; Congenital Anomaly Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Congenital Anomaly Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Uwabe
authors.affiliation: Institute of Applied Physics, University of Tsukuba, Ibaragi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kose
authors.affiliation: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takakuwa