title: 99mTc-3P-RGD2 molecular imaging targeting integrinαvβ3in head and neck squamous cancer xenograft.
abstract: 99mTc-3P-RGD2 and SPECT/CT were valuable tools for selecting patient likely benefit from integrinαvβ3blocking therapy. To evaluate the feasibility of99mTc-3P-RGD2 imaging to detect head and neck squamous cell carcinoma,99mTc-3P-RGD2 was prepared and the relationship between its accumulation and integrinαvβ3expression in nude mice bearing HEP-2 or CNE-1 carcinoma xenograft were analyzed. This study demonstrated that99mTc-3P-RGD2, with high affinity to integrinαvβ3, will provide basis forαvβ3involved individual therapy.
authors.affiliation: Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 China.
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006 China.
authors.forename: Fan
authors.initials: F
authors.lastname: Qiu
authors.affiliation: Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.affiliation: Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 China.
authors.forename: Haojie
authors.initials: H
authors.lastname: Dai
authors.affiliation: Cardiovascular Institute & Fu Wai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100037 China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100050 China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006 China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
keywords: 99mTc-3P-RGD2; Angiogenesis; Head and neck squamous cell carcinoma; Integrin αvβ3; Molecular imaging