title: Genomic sequence of the aflatoxigenic filamentous fungus Aspergillus nomius.
abstract: BACKGROUND
  Aspergillus nomius is an opportunistic pathogen and one of the three most important producers of aflatoxins in section Flavi. This fungus has been reported to contaminate agricultural commodities, but it has also been sampled in non-agricultural areas so the host range is not well known. Having a similar mycotoxin profile as A. parasiticus, isolates of A. nomius are capable of secreting B- and G- aflatoxins.
  
  
  RESULTS
  In this study we discovered that the A. nomius type strain (NRRL 13137) has a genome size of approximately 36 Mb which is comparable to other Aspergilli whose genomes have been sequenced. Its genome encompasses 11,918 predicted genes, 72% of which were assigned GO terms using BLAST2GO. More than 1,200 of those predicted genes were identified as unique to A. nomius, and the most significantly enriched GO category among the unique genes was oxidoreducatase activity. Phylogenomic inference shows NRRL 13137 as ancestral to the other aflatoxigenic species examined from section Flavi. This strain contains a single mating-type idiomorph designated as MAT1-1.
  
  
  CONCLUSIONS
  This study provides a preliminary analysis of the A. nomius genome. Given the recently discovered potential for A. nomius to undergo sexual recombination, and based on our findings, this genome sequence provides an additional evolutionary reference point for studying the genetics and biology of aflatoxin production.
authors.affiliation: United States Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, LA, USA. geromy.moore@ars.usda.gov.
authors.forename: Geromy G
authors.initials: GG
authors.lastname: Moore
authors.affiliation: United States Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, LA, USA. brian.mack@ars.usda.gov.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Mack
authors.affiliation: United States Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, LA, USA. shannon.beltz@ars.usda.gov.
authors.forename: Shannon B
authors.initials: SB
authors.lastname: Beltz
mesh_terms: D001230:Aspergillus / Q000235:genetics*; D019143:Evolution, Molecular; D063990:Gene Ontology; D049770:Genes, Mating Type, Fungal; D059646:Genome Size; D016681:Genome, Fungal; D010802:Phylogeny; D017422:Sequence Analysis, DNA / Q000379:methods*