title: Contribution of the IL-17 Pathway to Psoriasis and Psoriatic Arthritis.
abstract: Investigators have accrued compelling evidence that the IL-17 pathway is central to the pathogenesis of psoriasis and psoriatic arthritis. The evidence comprises genome-wide association studies (GWAS), data from experimental murine models and findings from in vitro studies on patients' cells or tissue biopsies. More recently, the success of drugs blocking the IL-17 pathway in treating both psoriasis (PsO) and psoriatic arthritis (PsA) confirms that IL-17 is a clinically relevant therapeutic target. However, there remain many unanswered questions: is PsA simply an extension of PsO from the skin to the synovial tissue or are there differences in the underlying pathogenesis of these diseases? Which cell type represents the primary source of IL-17 in PsO and PsA? And how are these cells regulated? This review outlines the IL-17 pathway, summarises the evidence supporting its role in PsO and PsA and discusses recent data that may help to address these yet unresolved questions.
authors.affiliation: Centre for Molecular and Cellular Biology of Inflammation (CMCBI), Division of Immunology, Infection and Inflammatory Disease, King's College London, London, SE1 1UL, UK, lucydurham@doctors.org.uk.
authors.forename: L E
authors.initials: LE
authors.lastname: Durham
authors.forename: B W
authors.initials: BW
authors.lastname: Kirkham
authors.forename: L S
authors.initials: LS
authors.lastname: Taams
mesh_terms: D000818:Animals; D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D002986:Clinical Trials as Topic / Q000379:methods; D003879:Dermatologic Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020381:Interleukin-17 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D051379:Mice; D058990:Molecular Targeted Therapy / Q000379:methods; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
chemical_list: D003879:Dermatologic Agents; D020381:Interleukin-17