title: An special epithelial staining agents: folic acid receptor-mediated diagnosis (FRD) effectively and conveniently screen patients with cervical cancer.
abstract: High-quality screening with cytology has markedly reduced mortality from cervical cancer. However, it needs experienced pathologists to review and make the final decisions. We have developed folic acid receptor-mediated diagnosis (FRD) kits to effectively and conveniently screen patients with cervical cancer. We conduct present study aim to assess clinical significances of FRD in screening cervical cancer. A total of 169 patients were enrolled at Chinese People's liberation Army (PLA) general hospital. We compared diagnostic significances of FRD with thinprep cytology test (TCT). Meanwhile, colposcopy was also performed to confirm any lesion suspicious for cervical cancer. The sensitivity and specificity of FRD were 71.93% and 66.07% in diagnosis cervical cancer, respectively. Meanwhile, the positive predictive values (PPV), negative predictive values (NPV), Youden index were 51.90%, 82.22%, 0.38, respectively. On the other hand, the sensitivity and specificity of TCT in diagnosis cervical cancer were 73.68% and 61.61% respectively. PPV, NPV and Youden index for TCT were 49.41%, 82.14% and 0.35 respectively. Overall, FRD have high values of sensitivity, specificity and Youden index. However, this difference failed to statistical significance. FRD have comparable diagnostic significance with TCT. Therefore, FRD might serve as one effective method to screen cervical cancer. Especially for those patients living in remote regions of China, where cytology was unavailable.
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Meng-Han
authors.initials: MH
authors.lastname: Lu
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Ling-Yun
authors.initials: LY
authors.lastname: Hu
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Du
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Wei-Yi
authors.initials: WY
authors.lastname: Zhang
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Li-An
authors.initials: LA
authors.lastname: Li
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Jiang
authors.affiliation: Department of Gynecology & Obstetrics, The PLA General Hospital 100853, China.
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Li
keywords: Cervical lesion; folate receptor; folic acid receptor-mediated diagnosis