title: Effect of Tri-sa-maw recipe on gastrointestinal regulation and motility. .
abstract: BACKGROUND
  Tri-sa-maw recipe is comprised ofequal proportions of three herbal fruits, including Terminalia chebula Retz., Terminalia sp. and Terminalia bellirica Roxb. The traditional use of this recipe has been reported as a medication for fever; expectorant, relief of tightness in the stomach, laxative and antidiarrheal agent.
  
  
  OBJECTIVE
  To study the effects of Tri-sa-maw recipe extract on gastrointestinal tract in both in vitro and in vivo.
  
  
  METHODS
  Gastrointestinal effect of Tri-sa-maw recipe was studied by using two in vivo models (gastric emptying, gastrointestinal transit) and in vitro isolated guinea pig ileum experiment.
  
  
  RESULTS
  Tri-sa-maw recipe showed both stimulatory and inhibitory effects on the stomach function. Not only did the extract at the dose of 1,000 mg/kg inhibit the gastric emptying time, but also stimulate the movement of the digestive tract by increasing the mobility of charcoal. In the isolated guinea pig ileum experiment, the extract at low concentration (0.1 ng/mL) induced the contraction of isolated guinea pig ileum. However the stimulation effect on contractions of isolated guineapig ileum was very much decreased at the high concentration (0.2-1 ng/mL) of the extract.
  
  
  CONCLUSIONS
  The findings of this study support to traditional uses of Tri-sa-maw recipe as a laxative and antidiarrheal agent.
authors.forename: Supaporn
authors.initials: S
authors.lastname: Wannasiri
authors.forename: Kanjana
authors.initials: K
authors.lastname: Jaijoy
authors.forename: Natthakarn
authors.initials: N
authors.lastname: Chiranthanut
authors.forename: Noppamas
authors.initials: N
authors.lastname: Soonthornchareonnon
authors.forename: Seewaboon
authors.initials: S
authors.lastname: Sireeratawong
mesh_terms: D000818:Animals; D005638:Fruit / Q000737:chemistry*; D005746:Gastric Emptying / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D029766:Terminalia / Q000737:chemistry*
chemical_list: D010936:Plant Extracts