title: Cerebral Microbleeds in Patients with Dementia with Lewy Bodies and Parkinson Disease Dementia.
abstract: OBJECTIVE
  The burden of amyloid β is greater in patients with dementia with Lewy bodies than in those with Parkinson disease dementia, and an increased amyloid β load is closely related to a higher incidence of cerebral microbleeds. Here, we investigated the prevalence and topography of cerebral microbleeds in patients with dementia with Lewy bodies and those with Parkinson disease dementia to examine whether cerebral microbleeds are more prevalent in patients with dementia with Lewy bodies than in those with Parkinson disease dementia.
  
  
  METHODS
  The study population consisted of 42 patients with dementia with Lewy bodies, 88 patients with Parkinson disease dementia, and 35 controls who underwent brain MR imaging with gradient recalled-echo. Cerebral microbleeds were classified as deep, lobar, or infratentorial.
  
  
  RESULTS
  The frequency of cerebral microbleeds was significantly greater in patients with dementia with Lewy bodies (45.2%) than in those with Parkinson disease dementia (26.1%) or in healthy controls (17.1%; P = .017). Lobar cerebral microbleeds were observed more frequently in the dementia with Lewy bodies group (40.5%) than in the Parkinson disease dementia (17%; P = .004) or healthy control (8.6%; P = .001) group, whereas the frequencies of deep and infratentorial cerebral microbleeds did not differ among the 3 groups. Logistic regression analyses revealed that, compared with the healthy control group, the dementia with Lewy bodies group was significantly associated with the presence of lobar cerebral microbleeds after adjusting for age, sex, nonlobar cerebral microbleeds, white matter hyperintensities, and other vascular risk factors (odds ratio, 4.39 [95% CI, 1.27-15.25]). However, compared with the healthy control group, the Parkinson disease dementia group was not significantly associated with lobar cerebral microbleeds.
  
  
  CONCLUSIONS
  This study showed that patients with dementia with Lewy bodies had a greater burden of cerebral microbleeds and exhibited a lobar predominance of cerebral microbleeds than did patients with Parkinson disease dementia.
authors.affiliation: From the Department of Neurology (S.W.K., S.J.C., P.H.L.), Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Kim
authors.affiliation: From the Department of Neurology (S.W.K., S.J.C., P.H.L.), Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Chung
authors.affiliation: Department of Neurology (Y.-S.O., J.-S.K.), Catholic University College of Medicine, Seoul, South Korea.
authors.forename: Y-S
authors.initials: YS
authors.lastname: Oh
authors.affiliation: Department of Neurology (J.H.Y.), Ajou University College of Medicine, Suwon, South Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Neurology (M.K.S.), Bundang Jesaeng General Hospital, Seongnam, South Korea.
authors.forename: M K
authors.initials: MK
authors.lastname: Sunwoo
authors.affiliation: Department of Neurology (J.Y.H.), Yonsei University Wonju College of Medicine, Wonju, South Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Hong
authors.affiliation: Department of Neurology (Y.-S.O., J.-S.K.), Catholic University College of Medicine, Seoul, South Korea.
authors.forename: J-S
authors.initials: JS
authors.lastname: Kim
authors.affiliation: From the Department of Neurology (S.W.K., S.J.C., P.H.L.), Yonsei University College of Medicine, Seoul, South Korea Severance Biomedical Science Institute (P.H.L.), Seoul, South Korea. phisland@chol.net.
authors.forename: P H
authors.initials: PH
authors.lastname: Lee
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000032:analysis; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000150:complications*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D016229:Amyloid beta-Peptides