title: Effects of lanthanum carbonate on vascular calcification in elderly maintenance hemodialysis patients.
abstract: The effect of lanthanum carbonate on abdominal aortic calcification (AAC) in the elderly maintenance hemodialysis (MHD) patients was investigated. Fifty-four cases subjected to routine MHD complicated with skin pruritus admitted to our hospital were selected and randomly divided into case group (n=28) and control group (n=26). The control group was given routine MHD alone. The case group was given lanthanum carbonate additionally on the basis of routine MHD. The changes of itching degrees at first and third month, and serum calcium, phosphorus, calcium-phosphorus products, intact parathyroid hormone (iPTH) levels and AAC scores at third month after treatments were compared between the two groups. The correlation between calcium-phosphorus products and AAC scores was also analyzed. There was no significant difference in the baseline of blood urea nitrogen (BUN), serum creatinine (Scr), uric acid, albumin, hemoglobin, C reactive protein (CRP), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride, total cholesterol between case group and control group (P>0.05 for all). There was also no significant difference in the baseline itching scores between the case group and the control group (P>0.05). At 1st and 3rd month after treatment, the itching scores in the case group were 14.2 ± 3.2 and 10.5 ± 2.3, respectively, which were significantly lower than the baseline and those in the control group (P<0.05 for all). At 1st and 3rd month after treatment, the itching scores in the control group were 23.6 ± 5.9 and 24.8 ± 6.3, respectively, which were significantly higher than the baseline (P<0.05). There was no significant difference in the baseline of serum calcium, phosphorus, calcium-phosphorus products, iPTH levels between the case group and control group (P>0.05). At 3rd month after treatment, serum phosphorus, calcium-phosphorus products and iPTH levels in the case group were decreased significantly as compared with the baseline (P<0.05), and the serum calcium, phosphorus, calcium-phosphorus products, and iPTH levels were statistically decreased as compared with those in the control group (P<0.05). The AAC scores showed statistically significant difference between the case group and the control group (P<0.05). The serum phosphorus and AAC scores showed a positive correlation in both two groups. It was suggested that the administration of lanthanum carbonate in the elderly MHD patients can effectively relieve itching, and simultaneously reduce serum phosphorus and iPTH levels, resulting in the attenuation of vascular calcification.
authors.affiliation: Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.|Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Mu
authors.affiliation: Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Qing-Ping
authors.initials: QP
authors.lastname: Peng
authors.affiliation: Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Guo-Sheng
authors.initials: GS
authors.lastname: Yang
authors.affiliation: Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Ming-Mei
authors.initials: MM
authors.lastname: Li
authors.affiliation: Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Duan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Nephrology, Wuhan Fifth Hospital, Wuhan, 430050, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. ghxding@gmail.com.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Ding
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007811:Lanthanum / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000032:analysis; D010710:Phosphates / Q000097:blood; D011537:Pruritus / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome; D061205:Vascular Calcification / Q000097:blood / Q000188:drug therapy*
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; C119467:lanthanum carbonate; D007811:Lanthanum