title: Biomimetic honeycomb-patterned surface as the tunable cell adhesion scaffold.
abstract: Inspired by the typically adhesive behaviors of fish skin and Parthenocissus tricuspidata, two different decorations of polystyrene honeycomb membrane (PSHCM) prepared by the breath figure approach were carried out with poly(N-(3-Sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium betaine)(polySBMA) to explore controllable bioadhesive surfaces. Casting and dip-coating were employed to graft polySBMA onto the plasma treated PSHCM. The polySBMA casted PSHCM showed a uniform covering layer on the PSHCM similar to the mucus layer of fish skin, presenting excellent antifouling properties. On the contrary, a dip-coated one showed the polySBMA aggregating on the honeycomb pore walls forming a large number of sucking disks such as the adhesive disks of the tendrils of P. tricuspidata, which remarkably boosts cell adhesion on substrates. Thus, bioadhesion could be regulated as desired by tuning the distribution of zwitterionic polymer on the honeycomb surface. The results may provide a new approach for the design of biomaterial surfaces.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China. qhlu@sjtu.edu.cn xueminlu@sjtu.edu.cn.
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Chen
authors.forename: Xuemin
authors.initials: X
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Lu
mesh_terms: D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D032701:Biomimetics / Q000379:methods*; D002448:Cell Adhesion; D011108:Polymers / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011137:Polystyrenes; C000613046:poly(N-(3-sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium betaine); D001622:Betaine