title: The Irish Kidney Gene Project--Prevalence of Family History in Patients with Kidney Disease in Ireland.
abstract: BACKGROUND
  The prevalence of kidney disease (KD) due to inherited genetic conditions in Ireland is unknown. The aim of this study was to characterise an adult kidney disease population in Ireland and to identify familial clusters of kidney disease within the population.
  
  
  METHODS
  This was a multicenter cross-sectional study of patients with kidney disease in the Republic of Ireland, from January 2014 to September 2014, recruiting from dialysis units and out-patient renal departments. A survey was performed by collecting data on etiology of kidney disease and whether a family history of kidney disease exists. Medical records were cross-referenced to confirm the etiology of kidney disease.
  
  
  RESULTS
  A total of 1,840 patients were recruited with a mean age of 55.9 years (range 17-94.5) and a male predominance (n = 1,095; 59.5%). A positive family history was reported by 629 participants (34.2%). Excluding polycystic kidney disease (n = 134, 7.3%), a positive family history was reported by 495 participants (26.9%). Kidney disease due to an unknown etiology was the commonest etiology in the non-polycystic kidney disease group with a positive family history (10.6%, n = 67). Kidney diseases that are not classically associated with familial inheritance including tubulo-interstitial kidney disease, congenital abnormalities of the kidney and urinary tract and glomerulonephritis demonstrated familial clustering.
  
  
  CONCLUSIONS
  In an Irish non-polycystic kidney disease population, 26.9% reports a positive family history. The commonest etiology of kidney disease in the positive family history cohort, excluding autosomal dominant polycystic kidney disease, was kidney disease due to unknown etiology. Examining families with kidney disease provides an opportunity to better understand disease pathogenesis and potentially identify genetic predispositions to kidney disease.
authors.affiliation: Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.
authors.forename: Dervla M
authors.initials: DM
authors.lastname: Connaughton
authors.forename: Sarah
authors.initials: S
authors.lastname: Bukhari
authors.forename: Peter
authors.initials: P
authors.lastname: Conlon
authors.forename: Eoin
authors.initials: E
authors.lastname: Cassidy
authors.forename: Michael
authors.initials: M
authors.lastname: O'Toole
authors.forename: Mardina
authors.initials: M
authors.lastname: Mohamad
authors.forename: John
authors.initials: J
authors.lastname: Flanagan
authors.forename: Triona
authors.initials: T
authors.lastname: Butler
authors.forename: Anne
authors.initials: A
authors.lastname: O'Leary
authors.forename: Limy
authors.initials: L
authors.lastname: Wong
authors.forename: John
authors.initials: J
authors.lastname: O'Regan
authors.forename: Sarah
authors.initials: S
authors.lastname: Moran
authors.forename: Patrick
authors.initials: P
authors.lastname: O'Kelly
authors.forename: Valerie
authors.initials: V
authors.lastname: Logan
authors.forename: Brenda
authors.initials: B
authors.lastname: Griffin
authors.forename: Matthew
authors.initials: M
authors.lastname: Griffin
authors.forename: Peter
authors.initials: P
authors.lastname: Lavin
authors.forename: Mark A
authors.initials: MA
authors.lastname: Little
authors.forename: Peter
authors.initials: P
authors.lastname: Conlon
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006306:Health Surveys; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D007674:Kidney Diseases / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000453:epidemiology / Q000235:genetics; D015995:Prevalence; D006435:Renal Dialysis / Q000706:statistics & numerical data; D012737:Sex Factors; D055815:Young Adult