title: Subthalamic stimulation: toward a simplification of the electrophysiological procedure.
abstract: BACKGROUND
  The aim of the present study was to assess the consequences of a simplification of the electrophysiological procedure on the post-operative clinical outcome after subthalamic nucleus implantation in Parkinson disease.
  
  
  METHODS
  Microelectrode recordings were performed on 5 parallel trajectories in group 1 and less than 5 trajectories in group 2. Clinical evaluations were performed 1 month before and 6 months after surgery.
  
  
  RESULTS
  After surgery, the UPDRS III score in the off-drug/on-stimulation and on-drug/on-stimulation conditions significantly improved by 66,9% and 82%, respectively in group 1, and by 65.8% and 82.3% in group 2 (P<0.05). Meanwhile, the total number of words (P<0.05) significantly decreased for fluency tasks in both groups. Motor disability improvement and medication reduction were similar in both groups.
  
  
  CONCLUSIONS
  Our results suggest that the electrophysiological procedure should be simplified as the team's experience increases.
authors.affiliation: Department of Neurology, Rouen University Hospital and University of Rouen, Rouen, France - david.maltete@chu-rouen.fr.
authors.forename: Damien
authors.initials: D
authors.lastname: Fetter
authors.forename: Stephane
authors.initials: S
authors.lastname: Derrey
authors.forename: Romain
authors.initials: R
authors.lastname: Lefaucheur
authors.forename: Alaina
authors.initials: A
authors.lastname: Borden
authors.forename: David
authors.initials: D
authors.lastname: Wallon
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chastan
authors.forename: David
authors.initials: D
authors.lastname: Maltete
mesh_terms: D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods; D055724:Electrophysiological Phenomena / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D011184:Postoperative Period; D020531:Subthalamic Nucleus / Q000601:surgery*; D016896:Treatment Outcome