title: [Mycoplasma Pneumoniae-Induced Meningoencephalitis].
abstract: In clinical practice, secondary infections of the central nervous system (CNS) represent rare yet severe complications of their respective primary infections. In this case report, we describe a 22-year-old patient with a medical history of Asthma bronchiale, who developed significant neurological deficits after a respiratory infection. The neurological symptoms progressed despite antibiotic therapy with vancomycin, ampicillin and ceftriaxone. The patient's cerebrospinal fluid and a cranial magnetic resonance imaging (MRI) furnished evidence of acute meningoencephalitis. Microbiological assessment confirmed an acute mycoplasma pneumonia infection. Changing the patient's antibiotic regimen to minocycline and prednisolone led to significant clinical improvement. Pathomechanisms and therapeutic options to treat meningoencephalitis will be discussed in the following.
authors.affiliation: Neurologische Klinik, RWTH Aachen.
authors.forename: C
authors.initials: C
authors.lastname: Özel
authors.affiliation: Neurologische Klinik, RWTH Aachen.
authors.forename: M
authors.initials: M
authors.lastname: Dafotakis
authors.affiliation: Klinik für Neuroradiologie, RWTH Aachen.
authors.forename: O
authors.initials: O
authors.lastname: Nikoubashman
authors.affiliation: Neurologische Klinik, RWTH Aachen.
authors.forename: J
authors.initials: J
authors.lastname: Litmathe
authors.affiliation: Neurologische Klinik, RWTH Aachen.
authors.forename: O
authors.initials: O
authors.lastname: Matz
authors.affiliation: Neurologische Klinik, RWTH Aachen.
authors.forename: U
authors.initials: U
authors.lastname: Schöne
mesh_terms: D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001249:Asthma / Q000150:complications; D002443:Ceftriaxone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008590:Meningoencephalitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D009177:Mycoplasma pneumoniae; D011019:Pneumonia, Mycoplasma / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D014640:Vancomycin / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D002443:Ceftriaxone; D000667:Ampicillin