title: A Novel Approach for the Treatment of Radiation-Induced Hemorrhagic Cystitis with the GreenLightTM XPS Laser.
abstract: BACKGROUND
  The treatment of pelvic malignancies with radiotherapy can develop severe sequelae, especially radiation-induced hemorrhagic cystitis. It is a progressive disease that can lead to the need for blood transfusion, hospitalizations, and surgical interventions. This tends to affect the quality of life of these patients, and management can at times be difficult. We have evaluated the GreenLight Xcelerated Performance System (XPS) with TruCoag, although primarily used for management of benign prostatic hypertrophy (BPH), for the treatment of radiation-induced hemorrhagic cystitis.
  
  
  METHODS
  After International Review Board (IRB) approval, a retrospectivechart review was performed in addition to a literature search. A series of four male patients, mean age of 81 years, with radiation-induced hemorrhagic cystitis secondary to radiotherapy for pelvic malignancies (3 prostate cancer, 1 rectal cancer) were successfully treated with the GreenLight laser after unsuccessful treatment with current therapies described in the literature.
  
  
  RESULTS
  All four patients treated with the GreenLight laser had resolution of their hematuria after one treatment and were discharge from the hospital with clear urine.
  
  
  CONCLUSIONS
  The GreenLight XPS laser shows promising results for the treatment of patients with radiation-induced hemorrhagic cystitis, and deserves further evaluation and validation, especially since there is limited data available in the literature regarding the use of this technology for the treatment of this devastating condition.
authors.affiliation: Department of Urology, University of South Florida, Tampa, Florida, USA.
authors.forename: Daniel Roberto
authors.initials: DR
authors.lastname: Martinez
authors.affiliation: Department of Urology, University of South Florida, Tampa, Florida, USA.
authors.forename: Cesar E
authors.initials: CE
authors.lastname: Ercole
authors.affiliation: Department of Urology, University of South Florida, Tampa, Florida, USA.
authors.forename: Juan Gabriel
authors.initials: JG
authors.lastname: Lopez
authors.affiliation: Department of Urology, University of South Florida, Tampa, Florida, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Parker
authors.affiliation: Department of Urology, University of South Florida, Tampa, Florida, USA.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Hall
mesh_terms: D000369:Aged, 80 and over; D003556:Cystitis / Q000209:etiology / Q000601:surgery*; D006417:Hematuria / Q000601:surgery; D006470:Hemorrhage / Q000209:etiology / Q000601:surgery*; D006801:Humans; D017075:Laser Coagulation / Q000379:methods*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000601:surgery*; D012004:Rectal Neoplasms / Q000532:radiotherapy; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016896:Treatment Outcome