title: Eosinophilia in Pulmonary Disorders.
abstract: Lung disease associated with marked peripheral blood eosinophilia is unusual and nearly always clinically significant. Once recognized, it is generally easy to manage, albeit with long-term systemic corticosteroids. A failure to respond to oral steroids in the context of good compliance suggests a malignant cause for the eosinophilia. An important development is the introduction of antieosinophil therapies, particularly those directed against the interleukin 5 pathway, which is hoped to provide benefit in the full spectrum of eosinophilic lung disease as well as asthma, reducing the burden of side effects and resultant comorbidities.
authors.affiliation: Department of Infection Immunity and Inflammation, Institute for Lung Health, University of Leicester, Groby Road, Leicester LE3 9QP, UK; Department of Respiratory Medicine and Allergy, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, UK.
authors.forename: Kerry
authors.initials: K
authors.lastname: Woolnough
authors.affiliation: Department of Infection Immunity and Inflammation, Institute for Lung Health, University of Leicester, Groby Road, Leicester LE3 9QP, UK; Department of Respiratory Medicine and Allergy, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, UK. Electronic address: aw24@le.ac.uk.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wardlaw
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D001249:Asthma / Q000175:diagnosis / Q000473:pathology*; D002465:Cell Movement; D015267:Churg-Strauss Syndrome / Q000175:diagnosis / Q000473:pathology*; D004804:Eosinophils / Q000166:cytology / Q000378:metabolism; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000473:pathology; D006373:Helminthiasis / Q000469:parasitology / Q000473:pathology; D006376:Helminths / Q000472:pathogenicity; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis / Q000473:pathology*; D008168:Lung / Q000166:cytology / Q000473:pathology; D008174:Lung Diseases, Parasitic / Q000175:diagnosis / Q000469:parasitology / Q000473:pathology*; D011657:Pulmonary Eosinophilia / Q000175:diagnosis / Q000473:pathology*; D013183:Sputum / Q000166:cytology
chemical_list: D000305:Adrenal Cortex Hormones
keywords: AFAD; Asthma; Eosinophilic granulomatosis with polyangiitis (EGPA); Eosinophilic pneumonia; Hypereosinophilic syndrome