title: Association between specific IgE to Staphylococcus aureus enterotoxins A and B and asthma control.
abstract: BACKGROUND
  Recent studies have found that serum levels of Staphylococcus aureus enterotoxin (SE)-IgE are higher in patients with severe asthma compared with patients with nonsevere asthma. However, the association between SE-IgE and asthma control is not fully understood. Furthermore, SEA and SEB were the first reported SEs and subdivided into different groups. The influences of SEA-IgE and SEB-IgE on asthma control have not been elucidated.
  
  
  OBJECTIVE
  To determine the relevance of SEA- and SEB-IgE in patients with adult asthma and to investigate the association of SEA-IgE, SEB-IgE, and asthma control, respectively.
  
  
  METHODS
  The serum concentrations of SEA- and SEB-IgE in 172 adults with asthma were measured with a fluorescent enzyme immunoassay.
  
  
  RESULTS
  The prevalence of SEA- and SEB-IgE was 16.2% and 22.1%, respectively. Total IgE levels and the prevalence of atopic dermatitis were higher in SEA-IgE- and SEB-IgE-positive patients than in SEA-IgE- and SEB-IgE-negative patients, respectively; more SEA-IgE- and SEB-IgE-positive patients owned pets. Sensitization to SEA was associated with a younger mean age and a younger mean age at asthma onset. Multiple regression analysis indicated an association between total IgE levels and SEB-IgE. The prevalence of poorly uncontrolled asthma was significantly higher in SEA-IgE-positive patients than in SEA-IgE-negative patients. In addition, fractional exhaled nitric oxide levels were higher in SEA-IgE-positive patients than in SEA-IgE-negative patients. Logistic regression analysis also identified an association between SEA-IgE and poor asthma control.
  
  
  CONCLUSIONS
  Our findings indicate that sensitization to SE, in particular SEA rather than SEB, is associated with poor asthma control in adults with asthma.
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan. Electronic address: tanakaa@med.showa-u.ac.jp.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Ohta
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Manabe
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Furukawa
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Naota
authors.initials: N
authors.lastname: Kuwahara
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Fukuda
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Jinno
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Hirai
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Miyata
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Munehiro
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Homma
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yokoe
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, Tokyo, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Sagara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000276:immunology* / Q000628:therapy*; D003430:Cross-Sectional Studies; D004768:Enterotoxins / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D012720:Severity of Illness Index; D013147:Spirometry; D013211:Staphylococcus aureus / Q000276:immunology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000485:Allergens; D004768:Enterotoxins; D009569:Nitric Oxide; C026066:enterotoxin A, Staphylococcal; D007073:Immunoglobulin E; C031818:enterotoxin B, staphylococcal