title: THE EFFECT OF COBALT CHLORIDE PRECONDITIONING ON PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY.
abstract: BACKGROUND
  Recent studies indicate that Cobalt Chloride (CoC12) modulates mitochondrial activity. There is emerging data suggesting that Paclitaxel-induced peripheral neuropathy (PIPN) is a consequence of the drug's mitochondrial toxicity.
  
  
  OBJECTIVE
  to assess the effect of CoC12 preconditioning on PIPN in an animal model.
  
  
  METHODS
  PIPN was induced by 7 daily consecutive i.p. Paclitaxel (PXT) administrations. Male BALB/c mice were divided into three groups as follows: group A--CoC12 (12.5 mg/kg b.w.) for three weeks (preconditioning) followed by I week of PXT, group B--saline for three weeks, followed by 1 week of PXT and group C--saline for four weeks. Thermal and mechanical allodynia were assessed by means of paw withdrawal latency (PWL).
  
  
  RESULTS
  In group A, CoC12 preconditioning lead to a decrease in both thermal and mechanical PWLs. 7 days after the last dose of PXT, however, values returned to normal in group A and allodynia for both thermal and mechanical stimuli was noted in group B (p < 0.05).
  
  
  CONCLUSIONS
  CoC12 preconditioning seems to protect against PIPN. Although CoC12 administration decreased thermal and mechanical PWLs, subsequent P administration did not lead to the persistent mechanical and thermal allodynia that was noted in the P-alone group. Further studies are required for determining the exact relationship between CoC12 and PIPN.
authors.forename: Teodora
authors.initials: T
authors.lastname: Alexa
authors.forename: A
authors.initials: A
authors.lastname: Luca
authors.forename: Cătălina
authors.initials: C
authors.lastname: Bohotin
authors.forename: Daniela
authors.initials: D
authors.lastname: Lupchian
authors.forename: I
authors.initials: I
authors.lastname: Stanciuc
authors.forename: Magda
authors.initials: M
authors.lastname: Bădescu
mesh_terms: D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017239:Paclitaxel / Q000633:toxicity*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D018696:Neuroprotective Agents; D003035:Cobalt; C018021:cobaltous chloride; D017239:Paclitaxel