title: Association between Drug-Induced Sleep Endoscopy and Measures of Sleep Apnea Burden.
abstract: OBJECTIVE
  To test the following associations: (1) complete obstruction on drug-induced sleep endoscopy (DISE) and polysomnographic and subjective measures of obstructive sleep apnea; (2) tongue base/epiglottic obstruction and apnea index.
  
  
  METHODS
  Retrospective cohort.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Subjects included surgically naïve adult patients with DISE. Chart extraction included demographics, polysomnography, and Epworth Sleepiness Scale and SNORE25 (Symptoms of Nocturnal Obstruction and Related Events 25) scores. Each DISE video was examined for complete obstruction at velum, oropharynx, tongue, epiglottis (VOTE system). Student's t test, correlation, and multivariate linear regression were performed.
  
  
  RESULTS
  Among 65 subjects, complete obstruction was observed at 0 (3%), 1 (46%), 2 (48%), and 3 (3%) subsites, respectively. Subjects with 0-1 subsites vs 2-4 subsites of complete obstruction had similar apnea indexes (13 ± 24 vs 12 ± 17, P = .78, 83% power to detect difference of 15), apnea-hypopnea indexes (30 ± 25 vs 31 ± 28, P = .96, 54% power to detect difference of 15), Epworth Sleepiness Scale scores (11 ± 7 vs 12 ± 5, P = .34, 91% power to detect difference of 5), and SNORE25 scores (2.0 ± 1.1 vs 1.9 ± 1.0, P = .70, 96% power to detect difference of 1.0), with similar results after adjusting for age, sex, body mass index, and tonsil status. Neither tongue base nor epiglottic obstruction was associated with apnea index.
  
  
  CONCLUSIONS
  The number of subsites with complete obstruction on DISE was not associated with polysomnographic, subjective sleepiness, and quality-of-life measures. Tongue base and epiglottic obstruction were not associated with apnea index. Larger detailed analyses are needed to determine the importance of each site and degree of obstruction seen on DISE.
authors.affiliation: Department of Otolaryngology, University of Washington School of Medicine, Seattle, Washington, USA Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, Washington, USA raj.dedhia@emory.edu.
authors.forename: Raj C
authors.initials: RC
authors.lastname: Dedhia
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, Washington, USA Surgery Service, Seattle Veterans Affairs Medical Center, Seattle, Washington, USA.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Weaver
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D015992:Body Mass Index; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000503:physiopathology; D014741:Video Recording
chemical_list: D018686:Anesthetics, Intravenous; D008874:Midazolam
keywords: apnea-hypopnea index; drug-induced sleep endoscopy; excessive daytime sleepiness; obstructive sleep apnea; polysomnography