title: Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences.
abstract: Synthetic cathinones, otherwise known as "bath salts", have gained significant attention in the last few years as a result of increased use and abuse. One such compound, 3,4-methylenedioxypyrovalerone (MDPV), is pharmacologically and behaviorally similar to cocaine and has been shown to possess both aversive and rewarding effects. For a host of other drugs, each of these effects (and their relative balance) can be influenced by a variety of factors, including sex, which in turn impacts drug taking behavior. In this context, the present assessment sought to determine whether males and females differed in MDPV-induced CTA and CPP. Both male and female Sprague-Dawley rats underwent a combined CTA/CPP procedure, in which an injection of one of three doses of MDPV (1.0, 1.8 or 3.2mg/kg) was paired with both a novel saccharin solution and a novel environment and changes in preferences for these stimuli were examined. Taste avoidance was evident in both sexes, although this avoidance was weaker in females compared to males. MDPV also produced place preferences in all drug-treated animals, but these preferences did not vary as a function of sex. The fact that females showed a weaker avoidance response compared to males (despite comparable preferences) suggests that females may have a heightened susceptibility to use and abuse of MDPV, paralleling results seen with cocaine and other stimulants. The present findings extend the behavioral characterization of MDPV and the factors that may alter its aversive and rewarding effects.
authors.affiliation: Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, United States. Electronic address: hk9905a@american.edu.
authors.forename: Heather E
authors.initials: HE
authors.lastname: King
authors.affiliation: Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, United States.
authors.forename: Alison
authors.initials: A
authors.lastname: Wakeford
authors.affiliation: Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, United States.
authors.forename: William
authors.initials: W
authors.lastname: Taylor
authors.affiliation: Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, United States.
authors.forename: Bradley
authors.initials: B
authors.lastname: Wetzell
authors.affiliation: Chemical Biology Research Branch, National Institute on Drug Abuse, Bethesda, MD 20892, United States.
authors.forename: Kenner C
authors.initials: KC
authors.lastname: Rice
authors.affiliation: Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, United States.
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Riley
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D052117:Benzodioxoles / Q000494:pharmacology*; D015198:Designer Drugs / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D013649:Taste / Q000187:drug effects* / Q000502:physiology; D000094982:Synthetic Cathinone
chemical_list: D052117:Benzodioxoles; D015198:Designer Drugs; D011759:Pyrrolidines; D000094982:Synthetic Cathinone
keywords: MDPV; Place preference; Sex differences; Taste avoidance