title: Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia.
abstract: Peripheral blood eosinophilia is commonly encountered in clinical practice. The causes of peripheral blood eosinophilia are varied, ranging from benign eosinophilia to malignancy. A careful history and physical examination along with directed clinical evaluation may help determine the cause. When uncontrolled, peripheral blood eosinophilia may result in end-organ damage and life-threatening complications. This article summarizes the differential diagnosis and evaluation of persistent marked eosinophilia.
authors.affiliation: Section of Allergy & Immunology, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Wexner Medical Center at the Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: curtis.159@osu.edu.
authors.forename: Casey
authors.initials: C
authors.lastname: Curtis
authors.affiliation: Section of Allergy & Immunology, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Wexner Medical Center at the Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Princess U
authors.initials: PU
authors.lastname: Ogbogu
mesh_terms: D016207:Cytokines / Q000378:metabolism; D004804:Eosinophils / Q000166:cytology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D025202:Molecular Diagnostic Techniques / Q000379:methods*
chemical_list: D016207:Cytokines
keywords: Eosinophilia; FIP1L1-PDGFRA; Hypereosinophilic syndrome; Lymphocytic hypereosinophilic syndrome (L-HES); Myeloproliferative hypereosinophilic syndrome (M-HES)