title: "Sudden Drop" in Blood Pressure is Associated With Recanalization After Thrombolysis.
abstract: We aim to investigate whether the phenomenon of "sudden drop" in blood pressure (BP) within the first 2 hours is associated with vessel recanalization.We retrospectively examined clinical and imaging data from a consecutive series of patients with stroke with large vessel occlusion treated with intravenous thrombolysis (IVT). BP was monitored every 15 minutes during the first 2 hours, then every 30 minutes for 6 hours, and then every hour for 16 hours.We observed the phenomenon of "sudden drop" in systolic BP (≥20 mm Hg) in 82 (50.9%) patients in the first 2 hours and vessel recanalization in 87 (54.0%) patients 24 hours after treatment. This phenomenon was independently associated with recanalization (odds ratio 2.100; 95% confidence interval: 1.085-4.062; P = 0.028) after adjusting for the history of atrial fibrillation, coronary heart disease, and hypertension.The phenomenon of "sudden drop" in systolic BP with 20 mm Hg or greater between 2 continuous measurements within the first 2 hours is associated with recanalization after IVT in patients with large vessel occlusion, especially for middle cerebral artery occlusion.
authors.affiliation: From the Department of Neurology (SY, KL, JC, ML), Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China; and University of California-Los Angeles Stroke Center (DSL), Los Angeles, California.
authors.forename: Shenqiang
authors.initials: S
authors.lastname: Yan
authors.forename: Keqin
authors.initials: K
authors.lastname: Liu
authors.forename: Jin
authors.initials: J
authors.lastname: Cao
authors.forename: David S
authors.initials: DS
authors.lastname: Liebeskind
authors.forename: Min
authors.initials: M
authors.lastname: Lou
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007022:Hypotension / Q000209:etiology* / Q000503:physiopathology; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D007262:Infusions, Intravenous; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015912:Thrombolytic Therapy / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D005343:Fibrinolytic Agents