title: A New Targeted Model of Experimental Autoimmune Encephalomyelitis in the Common Marmoset.
abstract: Multiple sclerosis (MS) is the most common cause for sustained disability in young adults, yet treatment options remain very limited. Although numerous therapeutic approaches have been effective in rodent models of experimental autoimmune encephalomyelitis (EAE), only few proved to be beneficial in patients with MS. Hence, there is a strong need for more predictive animal models. Within the past decade, EAE in the common marmoset evolved as a potent, alternative model for MS, with immunological and pathological features resembling more closely the human disease. However, an often very rapid and severe disease course hampers its implementation for systematic testing of new treatment strategies. We here developed a new focal model of EAE in the common marmoset, induced by myelin oligodendrocyte glycoprotein (MOG) immunization and stereotactic injections of proinflammatory cytokines. At the injection site of cytokines, confluent inflammatory demyelinating lesions developed that strongly resembled human MS lesions. In a proof-of-principle treatment study with the immunomodulatory compound laquinimod, we demonstrate that targeted EAE in marmosets provides a promising and valid tool for preclinical experimental treatment trials in MS research.
authors.affiliation: Institute of Neuropathology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
authors.forename: Ruth Martha
authors.initials: RM
authors.lastname: Stassart
authors.affiliation: Department of Cognitive Neurology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
authors.forename: Gunther
authors.initials: G
authors.lastname: Helms
authors.affiliation: Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany.|Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany.
authors.forename: Enrique
authors.initials: E
authors.lastname: Garea-Rodríguez
authors.affiliation: Institute of Neuropathology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Nessler
authors.affiliation: Teva Pharmaceutical Industries, Netanya, Israel.
authors.forename: Liat
authors.initials: L
authors.lastname: Hayardeny
authors.affiliation: Institute of Neuropathology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Wegner
authors.affiliation: Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany.|Encepharm GmbH, Göttingen, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Schlumbohm
authors.affiliation: Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany.|Encepharm GmbH, Göttingen, Germany.|Department of Neurology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
authors.forename: Eberhard
authors.initials: E
authors.lastname: Fuchs
authors.affiliation: Institute of Neuropathology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Brück
mesh_terms: D000818:Animals; D002144:Callithrix; D016207:Cytokines / Q000008:administration & dosage / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental; D005260:Female; D008297:Male; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000008:administration & dosage / Q000276:immunology
chemical_list: D016207:Cytokines; D063308:Myelin-Oligodendrocyte Glycoprotein
keywords: common marmoset; demyelination; experimental autoimmune encephalomyelitis; immunomodulation; laquinimod; multiple sclerosis