title: Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells.
abstract: CdSe quantum dots (QDs) are potential fluorescent reagents, but leakage of Cd and Se often induces cytotoxicity. Here we prepared CdSe-based QDs with glass to reduce their leakage and examined their cytotoxicity using keratinocyte cells. The cytotoxicity of the QDs with glass was obviously lower than that of the commercial QDs with polymer, suggesting their safety for biological applications.
authors.affiliation: a Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Ikeda , Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Ando
authors.affiliation: b Health Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Ikeda , Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Horie
authors.affiliation: b Health Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Ikeda , Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Akazawa-Ogawa
authors.affiliation: b Health Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Ikeda , Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hagihara
authors.affiliation: c Research Institute of Electrochemical Energy , National Institute of Advanced Industrial Science and Technology (AIST) , Ikeda , Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Murase
authors.affiliation: b Health Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Ikeda , Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shigeri
mesh_terms: D019187:Cadmium Compounds / Q000633:toxicity*; D002461:Cell Line, Transformed; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D004339:Drug Compounding; D005898:Glass / Q000737:chemistry; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects*; D053758:Nanoparticles / Q000633:toxicity*; D010316:Particle Size; D045663:Quantum Dots / Q000633:toxicity*; D018036:Selenium Compounds / Q000633:toxicity*
chemical_list: D019187:Cadmium Compounds; D018036:Selenium Compounds; C058667:cadmium selenide
keywords: CdSe; cytotoxicity; glass; polymer; quantum dot