title: Colistin neurotoxicity: revisited.
abstract: The revival of polymyxin antibiotics with the advent of multidrug resistant gram-negative bacteria in the recent decade has led to renewed interest in toxicity of this indispensable drug. We report a postoperative case of burst abdomen where colistin was started in view of Pseudomonas organism sensitive to colistin. Subsequently, the patient went into respiratory depression and encephalopathy after starting the treatment. She recovered promptly after stopping the drug.
authors.affiliation: Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, New Delhi, India.
authors.forename: Aruna
authors.initials: A
authors.lastname: Nigam
authors.affiliation: Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, New Delhi, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Kumari
authors.affiliation: Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
authors.forename: Reena
authors.initials: R
authors.lastname: Jain
authors.affiliation: Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, New Delhi, India.
authors.forename: Swaraj
authors.initials: S
authors.lastname: Batra
mesh_terms: D000900:Anti-Bacterial Agents / Q000633:toxicity; D001927:Brain Diseases / Q000139:chemically induced / Q000175:diagnosis; D003091:Colistin / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000175:diagnosis*; D011549:Pseudomonas / Q000187:drug effects / Q000472:pathogenicity*; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000175:diagnosis; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin