title: Organopromoted direct synthesis of 6-iodo-3-methylthioimidazo[1,2-a]pyridines via convergent integration of three self-sorting domino sequences.
abstract: An NH2CN-promoted convergent integration of three self-sorting domino sequences is described for the construction of 6-iodo-3-methylthioimidazo[1,2-a]pyridines from aryl methyl ketones and 2-aminopyridines. This strategy allows the construction of an imidazo[1,2-a]pyridine ring along with methylthiolation at C-3 and iodination at C-6. Preliminary mechanistic studies indicate that this process terminates at the iodination stage without Kornblum oxidation in the presence of I2 and DMSO.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China. gao_qinghe@163.com chwuax@mail.ccnu.edu.cn.
authors.forename: Shan
authors.initials: S
authors.lastname: Liu
authors.forename: Hailing
authors.initials: H
authors.lastname: Xi
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Gao
authors.forename: Anxin
authors.initials: A
authors.lastname: Wu
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents
chemical_list: D007093:Imidazoles; D007659:Ketones; D011725:Pyridines; D012997:Solvents; C023666:pyridine