title: Expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in esophageal cancer and their association with the clinical and pathological parameters.
abstract: OBJECTIVE
  To investigate correlations among A-kinase anchor protein95 (AKAP95), Connexin43 (Cx43), CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues, and their relationship with clinical and pathological parameters.
  
  
  METHODS
  The protein levels of AKAP95, Cx43, CyclinE1 and CyclinD1 in 54 cases of esophageal squamous cell cancer tissues were determined by immunohistochemistry.
  
  
  RESULTS
  The expression of AKAP95, CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues (53.70%, 88.89%, 72.22%, respectively) was significantly increased when compared to pericarcinoma tissues (20.00%, P < 0.05; 6.67%, P < 0.01; and 20.00%, P < 0.05; respectively). By contrast, Cx43 expression in esophageal squamous cell cancer tissues (22.22%) was lower than that in pericarcinoma tissues (60.00%, P < 0.05). The expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in the tissues of esophageal squamous cell carcinoma was unrelated to lymph node metastasis and the degree of differentiation. The expression of Cx43, CyclinE1, CyclinD1 in the tissues of esophageal squamous cell carcinoma was significantly correlated with AKAP95, respectively (P < 0.05).
  
  
  CONCLUSIONS
  Expression levels of AKAP95, CyclinE1 and CyclinD1 were higher, and that of Cx43 lower in esophageal squamous cell carcinoma tissues as compared pericarcinoma tissues, which suggests their importance in the incidence and development of esophageal squamous cell carcinoma. The expression of Cx43, CyclinE1, CyclinD1 in the tissues of esophageal squamous cell carcinoma was correlated with AKAP95, respectively. The expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in the tissues of esophageal squamous cell carcinoma was unrelated to the degree of differentiation and lymph node metastasis.
authors.affiliation: Department of Thyroid, Breast and Vascular Surgery, The First Affiliated Hospital of Liaoning Medical University Jinzhou 121001, Liaoning, PR China.
authors.forename: Shupeng
authors.initials: S
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Yi
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Zhuang
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Dengcheng
authors.initials: D
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Xiuyi
authors.initials: X
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Xiaoxuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Bogang
authors.initials: B
authors.lastname: Teng
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, Tianjin Medical University General Hospital 154 Anshan Road, Heping Section, Tianjin 300052, PR China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Guan
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Zhang
keywords: AKAP95; Cx43; CyclinD1; CyclinE1; Esophageal cancer; correlation analyses