title: [Sjögren's syndrome - case report].
abstract: BACKGROUND
  Sjögren's syndrome (SS) is a chronic autoimmune disease that primarily affects the lacrimal and salivary exocrine glands. In children, it is a rare condition.
  
  
  OBJECTIVE
  To present the case of an adolescent with non-specific symptoms, but with a clinical suspicion of SS.
  
  
  METHODS
  A male 12-year old patient, with history of arthralgias for 3 years and suspicion of xerophthalmia. Physical examination showed mild conjunctival congestion, dry mouth and hypermobility of the knees. Laboratory work: blood count and ESR were normal, antinuclear antibodies (+) > 60, Ro (+) > 60 U, and rheumatoid factor concentration (+) 160 IU / ml. SS was suspected, and a study was carried out: Schirmer test determined mild dry eye, salivary gland scintigraphy showed parotid and submandibular gland dysfunction, and salivary gland biopsy reported focal lymphocytic acinar and periductal infiltration. SS was confirmed and treated with prednisone 7.5mg/day and hydroxychloroquine 200mg/day, and local treatment, with good response.
  
  
  CONCLUSIONS
  The diagnostic criteria for SS in adults identified only 39% of pediatric patients, due to the low frequency of sicca symptoms. Still there are no validated diagnostic criteria for children. A good diagnosis will alleviate symptoms, prevent complications and detect associated diseases.
authors.affiliation: Reumatología Pediátrica, Hospital San Juan de Dios, Universidad de Chile, Chile.. Electronic address: mladinor@hotmail.com.
authors.forename: R Mabel
authors.initials: RM
authors.lastname: Ladino
authors.affiliation: Médico general, Hospital San Juan de Dios, Universidad de Chile, Chile.
authors.forename: O Angelina
authors.initials: OA
authors.lastname: Gasitulli
authors.affiliation: Residente de Pediatría, Hospital San Juan de Dios, Universidad de Chile, Chile.
authors.forename: M Ximena
authors.initials: MX
authors.lastname: Campos
mesh_terms: D002648:Child; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D010306:Parotid Gland / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012469:Salivary Glands / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome; D014985:Xerophthalmia / Q000209:etiology*; D014987:Xerostomia / Q000209:etiology*
chemical_list: D006886:Hydroxychloroquine; D011241:Prednisone
keywords: Diagnosis; Keratoconjunctivitis sicca; Pediatrics; Sjögren Syndrome; Síndrome de Sjögren; diagnóstico; pediatría; queratoconjuntivitis sicca