title: Increased oxidative stress and oxidative DNA damage in non-remission schizophrenia patients.
abstract: Increasing evidence shows that oxidative stress plays a role in the pathophysiology of schizophrenia. But there is not any study which examines the effects of oxidative stress on DNA in schizophrenia patients. Therefore we aimed to assess the oxidative stress levels and oxidative DNA damage in schizophrenia patients with and without symptomatic remission. A total of 64 schizophrenia patients (38 with symptomatic remission and 26 without symptomatic remission) and 80 healthy volunteers were included in the study. 8-hydroxydeoxyguanosine (8-OHdG), total oxidant status (TOS) and total antioxidant status (TAS) were measured in plasma. TOS, oxidative stress index (OSI) and 8-OHdG levels were significantly higher in non-remission schizophrenic (Non-R-Sch) patients than in the controls. TOS and OSI levels were significantly higher in remission schizophrenic (R-Sch) patients than in the controls. TAS level were significantly lower and TOS and OSI levels were significantly higher in R-Sch patients than in Non-R-Sch patients. Despite the ongoing oxidative stress in patients with both R-Sch and Non-R-Sch, oxidative DNA damage was higher in only Non-R-Sch patients compared to controls. It is suggested that oxidative stress can cause the disease via DNA damage, and oxidative stress plays a role in schizophrenia through oxidative DNA damage.
authors.affiliation: Department of Psychiatry, School of Medicine, Mustafa Kemal University, Hatay, Turkey. Electronic address: drsertancopoglu@yahoo.com.
authors.forename: U
authors.initials: U
authors.lastname: Sertan Copoglu
authors.affiliation: Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Virit
authors.affiliation: Department of Psychiatry, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Hanifi Kokacya
authors.affiliation: Department of Biochemistry, Sehitkamil State Hospital, Gaziantep, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Orkmez
authors.affiliation: Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Feridun
authors.initials: F
authors.lastname: Bulbul
authors.affiliation: Department of Biochemistry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Binnur Erbagci
authors.affiliation: Department of Psychiatry, Gulhane Military Medicine School, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Semiz
authors.affiliation: Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Gokay
authors.initials: G
authors.lastname: Alpak
authors.affiliation: Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Unal
authors.affiliation: Department of Psychiatry, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ari
authors.affiliation: Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Haluk A
authors.initials: HA
authors.lastname: Savas
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004249:DNA Damage / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D012074:Remission Induction; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D016877:Oxidants
keywords: 8-hydroxydeoxyguanosine; Oxidative DNA damage; Oxidative stress; Schizophrenia; Symptomatic remission