title: The Effects of Topical Hemocoagulase Solution on the Healing Process of Post-extraction Wounds: A Split Mouth Design.
abstract: OBJECTIVE
  To evaluate the effects of topical hemocoagulase on intra-oral extraction sockets and impact on the healing process as well as to produce a clinico-histological healing score.
  
  
  METHODS
  This prospective study compared two extraction sites in each subject. One site received topical hemocoagulase while other site did not receive it. Both the sites were chosen in the same patient and extraction was done at separate intervals. The biopsy was done on a random basis with the pathologist being blinded to the study. Clinical evaluation was done on days 7, 14 and 21. Biopsy was done either on days 7 or 14 for the case as well as for the control. A clinical as well as histological score was developed and the healing was assessed. Statistical analysis was done using Wilcoxon signed rank test and p value ≤ 0.05 was considered significant and z-score was also calculated.
  
  
  RESULTS
  The clinical score did not show any statistical significance. The histological total score on day 14 and combined overall analysis of days 7 and 14 showed statistical significance. There was an increased incidence (n = 4) of osteoid formation in the hemocoagulase group on day 14.
  
  
  CONCLUSIONS
  The application of hemocoagulase may improve and accelerates the process of wound healing in extraction sockets.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Thai Moogambigai Dental College, Chennai, India ; 9A, 9th Floor, Orchards, Peach Block, 85-87, Arcot Road, Vadapalani, Chennai, 600026 Tamil Nadu India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Shenoy K
authors.affiliation: Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Mangalore, India.
authors.forename: Mohan
authors.initials: M
authors.lastname: Baliga
authors.affiliation: Department of Oral Pathology, Manipal College of Dental Sciences, Mangalore, India.
authors.forename: Sumitha
authors.initials: S
authors.lastname: Mahajan
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Mangalore, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: K V
keywords: Clinical healing; Extraction socket healing; Healing score; Histological healing; Topical Haemocoagulase