title: Management of concomitant coronary artery disease in patients undergoing transcatheter aortic valve implantation: the United Kingdom TAVI Registry.
abstract: BACKGROUND
  The management and impact of concomitant coronary artery disease in patients referred for TAVI remains contentious. We describe the prevalence, clinical impact and management of coronary artery disease (CAD) in patients in the United Kingdom TAVI Registry.
  
  
  METHODS
  All-inclusive study of patients undergoing TAVI in the United Kingdom (excluding Northern Ireland) from January 2007 to December 2011. Coronary artery disease at the time of TAVI was demonstrated on invasive angiography.
  
  
  RESULTS
  2588 consecutive patients were entered in the U.K. TAVI Registry. CAD was reported in 1171 pts with left main stem involvement in 12.4% of this cohort (n=145). Most patients were free of chest pain, but limited by dyspnoea (NYHA Class III & IV 81.9%). Angina was however more prevalent in those patients with CAD (p<0.0001). Hybrid PCI was uncommon, performed in only 14.7% of the CAD cohort (n=172). Survival at 30days, 1year, and 4years was 93.7%, 81.4% and 72.0% respectively. Adjusting for confounders in a multivariate model the presence and extent of CAD was not associated with early (30-days, p=0.36) or late (4years, p=0.10) survival.
  
  
  CONCLUSIONS
  This contemporary study of coronary artery disease management in an "all-comers" patient population undergoing TAVI demonstrates that whilst often an indicator of significant underlying comorbidity coronary artery disease is not associated with decreased short or long-term survival. The majority of patients with aortic stenosis and concomitant CAD can be managed effectively by TAVI alone. However, the importance of the Heart Team in making decisions on individual patients must not be underestimated.
authors.affiliation: Cardiovascular Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust, London, UK.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Snow
authors.affiliation: Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Ludman
authors.affiliation: Cardiovascular Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust, London, UK; Imperial College, London, UK.
authors.forename: Winston
authors.initials: W
authors.lastname: Banya
authors.affiliation: The James Cook University Hospital, Middlesbrough, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: DeBelder
authors.affiliation: King's College Hospital, London, UK.
authors.forename: Philip M
authors.initials: PM
authors.lastname: MacCarthy
authors.affiliation: Cardiovascular Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust, London, UK.
authors.forename: Simon W
authors.initials: SW
authors.lastname: Davies
authors.affiliation: Cardiovascular Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust, London, UK; Imperial College, London, UK.
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Mario
authors.affiliation: Cardiovascular Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust, London, UK. Electronic address: n.moat@rbht.nhs.uk.
authors.forename: Neil E
authors.initials: NE
authors.lastname: Moat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D019468:Disease Management; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D012189:Retrospective Studies; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods*; D016896:Treatment Outcome; D006113:United Kingdom
keywords: Aortic valve disease; Coronary artery disease; Transcatheter aortic valve implantation