title: Hematology and Clinical Chemistry Measures During and After Pregnancy and Age- and Sex-Specific Reference Intervals in African Green Monkeys (Chlorocebus aethiops sabaeus).
abstract: Clinical decisions and experimental analyses often involve the assessment of hematology and clinical chemistry. Using clinical pathology to assess the health status of NHP in breeding colonies or data from studies than involve pregnancy can often be complicated by pregnancy status. This study had 2 objectives regarding the hematology and clinical chemistry of African green monkeys (AGM, Chlorocebus aethiops sabaeus): 1) to compare pregnant or recently postpartum animals with nonpregnant, nonlactating animals and 2) to create age- and sex-specific reference intervals. Subjects in this study were 491 AGM from the Vervet Research Colony of the Wake Forest University Primate Center. Results indicated that changes in BUN, serum total protein, albumin, ALP, GGT, calcium, phosphorus, sodium, potassium, cholesterol, total CO2, globulins, lipase, amylase, WBC, neutrophils, lymphocytes, platelets, RBC, Hgb, and Hct occur during pregnancy and the postpartum period. Age- and sex-specific reference intervals consistent with guidelines from the American Society for Veterinary Clinical Pathology were established and further expand the understanding of how to define health in AGM on the basis of clinical pathology. The combination of understanding the changes that occur in pregnancy and postpartum and expansive reference intervals will help guide clinical and experimental decisions.
authors.affiliation: University of Washington, Washington National Primate Research Center, Seattle, Washington, USA.
authors.forename: Lee
authors.initials: L
authors.lastname: Chichester
authors.affiliation: Wake Forest University, Animal Resources Program, Winston-Salem, North Carolina, USA; Wake Forest School of Medicine, Department of Pathology, Section on Comparative Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Melaney K
authors.initials: MK
authors.lastname: Gee
authors.affiliation: Wake Forest School of Medicine, Department of Pathology, Section on Comparative Medicine, Winston-Salem, North Carolina, USA. mjorgens@wakehealth.edu.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Jorgensen
authors.affiliation: Wake Forest School of Medicine, Department of Pathology, Section on Comparative Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Jay R
authors.initials: JR
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops / Q000097:blood* / Q000502:physiology*; D005260:Female; D006403:Hematologic Tests / Q000662:veterinary*; D008297:Male; D009504:Neutrophils; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy / Q000097:blood*; D012016:Reference Values; D012727:Sex Characteristics