title: [An increase of infective endocarditis cases in England seen with concomitant reduction in antibiotic prophylaxis since the implementation of NICE guidelines in 2008: possible explanations].
abstract: Dayer and colleagues recently reported in The Lancet an increased incidence of infective endocarditis in England since 2008, year of NICE guideline on the restriction of antibiotic prophylaxis. They observed a concomitant decrease in the use of antibiotic prophylaxis. The temporal link between reduction of prophylaxis prescribing and increase of infective endocarditis raises the question of whether there is a causal association. In view of this observation, should we rethink antibiotic prophylaxis to prevent infective endocarditis?
authors.affiliation: Department of Infection, Royal London Hospital, Barts Healthcare NHS Trust, London, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Tiberi
authors.affiliation: Department of Infection, Royal London Hospital, Barts Healthcare NHS Trust, London, UK.
authors.forename: Frederick
authors.initials: F
authors.lastname: Pink
authors.affiliation: Department of Infection, Royal London Hospital, Barts Healthcare NHS Trust, London, UK.
authors.forename: Angelina
authors.initials: A
authors.lastname: Jayakumar
authors.affiliation: Dipartimento di Cardiologia, Ospedale di Circolo, Busto Arsizio (VA).
authors.forename: Francesco
authors.initials: F
authors.lastname: Arioli
mesh_terms: D019072:Antibiotic Prophylaxis / Q000639:trends*; D004696:Endocarditis / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D004739:England / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'