title: Mechanical consequences of allergic induced remodeling on mice airway resistance and compressibility.
abstract: The effect of remodeling on airway function is uncertain. It may affect airway compressibility during forced expirations differently than airflow resistance, providing a tool for its assessment. The aim of the current study was to compare the effects of acute and chronic antigen challenge on methacholine-induced bronchoconstriction assessed from resistance and maximal tidal expiratory flow. Balb/C mice were sensitized with ovalbumin (OVA) and challenged either daily for three days with intra-nasal OVA or daily for 5 days and three times a week for 5 subsequent weeks. Acute and chronic allergen challenge induced airway hyperresponsiveness (AHR) to methacholine. However the relationship between maximal tidal expiratory flow and resistance during methacholine challenge was different between the two conditions, suggesting that the determinants of AHR are not identical following acute and chronic allergen exposure. We conclude that the contrast of changes in maximal tidal expiratory flow and respiratory resistance during methacholine-induced bronchoconstriction may allow the detection of the mechanical consequences of airway remodeling.
authors.affiliation: Meakins Christie Laboratories, Department of Medicine, McGill University and the Research Institute of the McGill University Health Centre, Montreal, Qc, Canada.
authors.forename: Mauro
authors.initials: M
authors.lastname: Novali
authors.affiliation: Meakins Christie Laboratories, Department of Medicine, McGill University and the Research Institute of the McGill University Health Centre, Montreal, Qc, Canada.
authors.forename: Karim H
authors.initials: KH
authors.lastname: Shalaby
authors.affiliation: SCIREQ Scientific Respiratory Equipment Inc., Montreal, Qc, Canada.
authors.forename: Annette
authors.initials: A
authors.lastname: Robichaud
authors.affiliation: Meakins Christie Laboratories, Department of Medicine, McGill University and the Research Institute of the McGill University Health Centre, Montreal, Qc, Canada.
authors.forename: Andrea
authors.initials: A
authors.lastname: Benedetti
authors.affiliation: SCIREQ Scientific Respiratory Equipment Inc., Montreal, Qc, Canada.
authors.forename: Liah
authors.initials: L
authors.lastname: Fereydoonzad
authors.affiliation: Meakins Christie Laboratories, Department of Medicine, McGill University and the Research Institute of the McGill University Health Centre, Montreal, Qc, Canada.
authors.forename: Toby K
authors.initials: TK
authors.lastname: McGovern
authors.affiliation: SCIREQ Scientific Respiratory Equipment Inc., Montreal, Qc, Canada.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Schuessler
authors.affiliation: Meakins Christie Laboratories, Department of Medicine, McGill University and the Research Institute of the McGill University Health Centre, Montreal, Qc, Canada. Electronic address: james.martin@mcgill.ca.
authors.forename: James G
authors.initials: JG
authors.lastname: Martin
mesh_terms: D000208:Acute Disease; D056151:Airway Remodeling / Q000187:drug effects / Q000502:physiology*; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D016085:Bronchoconstrictor Agents / Q000494:pharmacology; D002908:Chronic Disease; D004195:Disease Models, Animal; D004548:Elasticity; D005260:Female; D020397:Goblet Cells / Q000473:pathology; D016210:Methacholine Chloride / Q000494:pharmacology; D008807:Mice, Inbred BALB C; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010047:Ovalbumin; D012123:Pulmonary Ventilation / Q000187:drug effects / Q000502:physiology; D011897:Random Allocation; D012130:Respiratory Hypersensitivity / Q000473:pathology / Q000503:physiopathology*; D013990:Tidal Volume / Q000187:drug effects / Q000502:physiology
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D010047:Ovalbumin
keywords: Airway hyperresponsiveness; Airway remodeling; Airway resistance; Maximal expiratory flow; Respiratory resistance