title: Analgesic and antipyretic activity of Tri-sa-maw recipe.
abstract: BACKGROUND
  Tri-sa-maw recipe is composed of equal proportions of the three fruits including Terminalia chebula Retz., Terminalia sp. and Terminalia bellirica Roxb. In Southeast Asia, these fruits are used as both food and medicine. In Thai traditional medicine, Tri-sa-maw recipe is well known for treating fever, expectorant, periodic maintenance, and tight stomach relief
  
  
  OBJECTIVE
  To study anti-inflammatory, analgesic and antipyretic activities of Tri-sa-maw recipe in experimental animals.
  
  
  METHODS
  The anti-inflammatory study was conducted by two experimental models; ethyl phenylpropiolate- induced ear edema and carrageenin-induced paw edema. For analgesic activity, the pain was induced by acetic acid or heat. In addition, yeast-induced hyperthermia was performedfor the study of antipyretic activity.
  
  
  RESULTS
  The results showed that Tri-sa-maw recipe extract reduced ear edema ofrat induced by EPP but did not inhibit acute inflammation in the carrageenin-inducedpaw edema. However the extract at the doses of 300-1,200 mg/kg was able to inhibit the acetic acid-induced writhing response, but not the heat-induced pain. This result suggests the peripheral effect of its analgesic activity, which inhibits the biosynthesis, and/or release of some pain mediators. Finally, oral administration ofthe extract at the dose of 1,200 mg/kg body weight effectively reduced the hyperthermia, which possibly is due to the inhibition of prostaglandins.
  
  
  CONCLUSIONS
  The present study has clearly demonstrated both analgesic and antipyretic activities of Tri-sa-maw recipe.
authors.forename: Urarat
authors.initials: U
authors.lastname: Nanna
authors.forename: Kanjana
authors.initials: K
authors.lastname: Jaijoy
authors.forename: Noppamas
authors.initials: N
authors.lastname: Soonthornchareonnon
authors.forename: Seewaboon
authors.initials: S
authors.lastname: Sireeratawong
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D029766:Terminalia / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D010936:Plant Extracts