title: The impact of Clostridum difficile on surgical rate among ulcerative colitis patients: A systemic review and meta-analysis.
abstract: There is growing recognition of the impact of Clostridum difficile infection (CDI) on patients with inflammatory bowel disease. Clostridium difficile infection causes greater morbidity and mortality. This study aimed to evaluate the impact of C. difficile on surgical risk among ulcerative colitis (UC) patients. We searched the following databases: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, ACP Journal Club, DARE, CMR, and HTA. Studies were included if fulfilled the following criteria: (1) Cohort or case-control studies, which involved a comparison group that lacked CDI, (2) Patients were given a primary diagnosis of UC, (3) Comorbidity of CDI was evaluated by enzyme immunoassay of stool for C. difficile toxin A and B or C. difficile stool culture, (4) Studies evaluated surgical rate, and (5) Studies reported an estimate of odds ratio, accompanied by a corresponding measure of uncertainty. Five studies with 2380 patients fulfilled the inclusion criteria. Overall, meta-analysis showed that UC with CDI patients had a significant higher surgical rate than patients with UC alone. (OR=1.76, 95% CI=1.36-2.28). C. difficile infection increased the surgical rate in UC patients. However, results should be interpreted with caution, given the limitations of this stud.
authors.forename: Jiang-Chen
authors.initials: JC
authors.lastname: Peng
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, 160# Pu Jian Avenue, 200127 Shanghai, China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Ran
mesh_terms: D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000150:complications* / Q000601:surgery; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000601:surgery*; D006801:Humans