title: Effect and Mechanism of Virechana Karma (Therapeutic Purgation) Over Fructose-Induced Metabolic Syndrome: An Experimental Study.
abstract: BACKGROUND
  Panchakarma (biopurification methods) is one of the modes of ayurveda to treat disorders of the body. Virechana karma (therapeutic purgation), one among the Panchakarma, is a purification process that is commonly used to treat metabolic disorders like obesity and diabetes mellitus. Hence this study was planned to provide evidence through animal experiments.
  
  
  METHODS
  Albino rats were subject to Virechana karma (therapeutic purgation) to evaluate the influence of therapy and its mechanism over fructose-induced metabolic syndrome.
  
  
  RESULTS
  Results show that Virechana is effective in the management of the metabolic syndrome with decrease in the fecal fat content, fasting blood glucose, serum triglyceride, and reduced fatty changes in liver, heart, and kidney in comparison with the positive control group.
  
  
  CONCLUSIONS
  Experimental evaluation showed decrease in fatty acid in the storage like liver, kidney, heart, and muscle adipose tissue can indirectly increase the insulin sensitivity in insulin receptor present at skeletal muscles.
authors.affiliation: SDM College of Ayurveda, Hassan, Karnataka, India drashutoshchaturvedi@hotmail.com.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Chaturvedi
authors.affiliation: SDM College of Ayurveda, Hassan, Karnataka, India.
authors.forename: Prasanna N
authors.initials: PN
authors.lastname: Rao
authors.affiliation: SDM College of Ayurveda, Hassan, Karnataka, India.
authors.forename: M Ashvini
authors.initials: MA
authors.lastname: Kumar
authors.affiliation: SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, Karnataka, India.
authors.forename: B
authors.initials: B
authors.lastname: Ravishankar
authors.affiliation: SDM College of Ayurveda, Udupi, Karnataka, India.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Rao
authors.affiliation: SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Ravi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005632:Fructose / Q000009:adverse effects*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008515:Medicine, Ayurvedic; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000378:metabolism / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D005632:Fructose
keywords: Panchakarma; ayurveda; insulin resistance; insulin sensitivity; metabolic syndrome