title: Antibacterial constituents of Neohyptis paniculata.
abstract: A new α-pyrone, 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one (1), along with six known compounds including an α-pyrone, flavones and terpenes was isolated from the aerial parts of Neohyptis paniculata. The structure of 1 was established unambiguously by MS and a series of 1D and 2D-NMR spectroscopic analyses. The antibacterial activity of the compounds (1-7) was investigated against five strains of multi-drug resistant (MDR) and methicillin-resistant Staphylococcus aureus and minimum inhibitory concentrations (MICs) of these compounds were found to be in the range of 64-256 μg/mL.
authors.affiliation: Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK; Medicine Research Group, School of Health, Sport and Bioscience, University of East London, Stratford Campus, Water Lane, London E15 4LZ, UK. Electronic address: m.rahman@uel.ac.uk.
authors.forename: M Mukhlesur
authors.initials: MM
authors.lastname: Rahman
authors.affiliation: Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D019686:Lamiaceae / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: C000603098:6-(5,6-diacetyloxy-1,3-heptadienyl)-5,6-dihydro-2H-pyran-2-one; D000900:Anti-Bacterial Agents; D011753:Pyrones
keywords: 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one; Antibacterial; Lamiaceae; Neohyptis paniculata; Staphylococcus aureus; α-Pyrone