title: The wacky hypercoagulable state of malignancy.
abstract: In this issue of Blood, Warkentin et al describe a novel clinical syndrome of warfarin-associated severe venous limb ischemia occurring in a series of 10 patients with malignancy after initiating treatment of deep venous thrombosis. Patients in this series also demonstrated a decline in platelet counts after stopping heparin, warfarin-associated supratherapeutic international normalized ratios (INRs), and evidence of persistent thrombin generation despite anticoagulation.
authors.affiliation: CLEVELAND CLINIC.
authors.forename: Alok A
authors.initials: AA
authors.lastname: Khorana
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D005260:Female; D005734:Gangrene / Q000139:chemically induced*; D006801:Humans; D007511:Ischemia / Q000139:chemically induced*; D007866:Leg / Q000098:blood supply*; D008297:Male; D009369:Neoplasms / Q000503:physiopathology*; D020246:Venous Thrombosis / Q000150:complications*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin