title: [Effect of Capsicum annum L (pucunucho, ají mono) in gastric ulcer experimentally induced in rats].
abstract: OBJECTIVE
  To examine the effects of the Capsicum annum L lyophilized fruit extract in experimentally-induced gastric ulcer in rats.
  
  
  METHODS
  We used the model of indomethacin gastric ulcer-induced and the gastric ulcer model induced by pylorus ligation in rats. The rats were divided in five treatment groups as follow: G1: Distilled water 1 ml/Kg; G2: Ranitidine 50 mg/kg, G3: Capsicum 10mg/kg, G4: Capsicum 100 mg/kg, G5: Capsicum 1000 mg/kg.
  
  
  RESULTS
  The results of the first model showed an ulcer inhibition of 60,4% and 66,7% using the doses of Capsicum at 10 mg/kg and 100 mg/kg, respectively. The results of the second model showed that neither the pH nor the volume of the gastric content were modified by the administered extract (p >0.05); however, by using the doses of Capsicum at 100 mg/kg and 1000 mg/kg, there was clearly an ulcer inhibition of 75.59% and 81.63% respectively, which were even greater than the inhibition obtained by ranitidine (75.51%).
  
  
  CONCLUSIONS
  Therefore, in this experiment we demonstrated that the Capsicum annum L lyophilized fruit extract has a gastroprotective effect in experimentally-induced gastric ulcer in rats.
authors.affiliation: Laboratorio de Investigación de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.
authors.forename: Rocío
authors.initials: R
authors.lastname: Delgado Montero
authors.affiliation: Laboratorio de Investigación de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.
authors.forename: Daisy
authors.initials: D
authors.lastname: Flores Cortez
authors.affiliation: Laboratorio de Investigación de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Villalobos Pacheco
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002212:Capsicum; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007213:Indomethacin; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D007213:Indomethacin