title: Effect of a 1-week, eucaloric, moderately high-fat diet on peripheral insulin sensitivity in healthy premenopausal women.
abstract: OBJECTIVE
  To determine whether a weight-maintaining, moderate (50%) high-fat diet is deleterious to insulin sensitivity in healthy premenopausal women.
  
  
  METHODS
  23 African-American and non-Hispanic white, healthy, overweight, and obese premenopausal women recruited in New York City, USA, fed either a eucaloric, 1-week long high-fat (50% of total Kcal from fat) diet or a eucaloric, 1-week long low-fat (30% of total Kcal from fat) diet, assigned in a randomized crossover design.
  
  
  METHODS
  Peripheral insulin sensitivity and metabolic flexibility during a euglycemic hyperinsulinemic (80 mU/m(2)/min) clamp measured during the follicular phase of the menstrual cycle, at the end of each diet period.
  
  
  RESULTS
  Peripheral insulin sensitivity (mg kg/fat-free mass/min (µU/mL)×10(-1)) was not decreased after the high-fat diet vs the low-fat diet (0.09±0.01 vs 0.08±0.01, p=0.09, respectively) in the combined group of African-American and white women, with no significant diet by race interaction (p=0.6). Metabolic flexibility (change in substrate utilization, ΔNPRQ, in response to insulin during the clamp) was similarly unaltered by the diet (0.12±0.01 vs 0.11, p=0.48, for the high-fat diet vs the low-fat diet, respectively) in the combined group of women, with no significant diet by race interaction (p=0.9). African-American women had a lower insulin clearance compared with the white women, regardless of the diet (p<0.05).
  
  
  CONCLUSIONS
  We conclude that a short term (1 week), moderate (50%), eucaloric high-fat diet does not lower peripheral insulin sensitivity in healthy, overweight and obese premenopausal women.
authors.affiliation: New York Obesity Research Center, St. Luke's Roosevelt Hospital Center , New York, New York , USA ; Division of Endocrinology, Diabetes and Metabolism , University of Rochester School of Medicine and Dentistry , Rochester, New York , USA.
authors.forename: Natalia M
authors.initials: NM
authors.lastname: Branis
authors.affiliation: New York Obesity Research Center, St. Luke's Roosevelt Hospital Center , New York, New York , USA ; Department of Medicine , Palomar Medical Center , Escondido, California , USA.
authors.forename: Marjan
authors.initials: M
authors.lastname: Etesami
authors.affiliation: New York Obesity Research Center, St. Luke's Roosevelt Hospital Center , New York, New York , USA ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , New York, New York , USA.
authors.forename: Ryan W
authors.initials: RW
authors.lastname: Walker
authors.affiliation: New York Obesity Research Center, St. Luke's Roosevelt Hospital Center , New York, New York , USA ; Nutrition Performance Unit , Glaxo Smith Kline , Parsippany, New Jersey , USA.
authors.forename: Evan S
authors.initials: ES
authors.lastname: Berk
authors.affiliation: New York Obesity Research Center, St. Luke's Roosevelt Hospital Center , New York, New York , USA ; Division of Endocrinology, Diabetes and Nutrition , Mount Sinai St Luke's and Mount Sinai Roosevelt Hospitals, Icahn School of Medicine at Mount Sinai , New York, New York , USA.
authors.forename: Jeanine B
authors.initials: JB
authors.lastname: Albu
keywords: African American(s); Dietary Fat; Euglycemic Clamp; Insulin Resistance