title: Association of matrix metalloproteinase family gene polymorphisms with lung cancer risk: logistic regression and generalized odds of published data.
abstract: Many studies have reported the association between the matrix metalloproteinase (MMP) polymorphisms and lung cancer susceptibility, but the results were inconclusive. We conducted a meta-analysis, using a comprehensive strategy based on the logistic regression and a model-free approach, to derive a more precise estimation of the relationship between MMP1, MMP2, MMP9 and MMP13 polymorphisms with lung cancer risk. A total of 22 case-control studies including 8202 cases and 7578 controls were included in this meta-analysis. For MMP1-1607 1G/2G, increased lung cancer risk was found among Asians in additive model(OR = 1.34, 95%CI:1.18-1.53) and with model-free approach(ORG = 1.41, 95%CI:1.21-1.65). For MMP2-1306 C/T and -735 C/T, based on the model-free approach, a significantly reduced risk was found in Asians(MMP2-1306 C/T:ORG = 0.49,95%CI:0.42-0.57; MMP2-735 C/T: ORG = 0.71, 95%CI:0.61-0.84). For MMP9-1562 C/T, a significantly increased risk was found among Asians(OR = 2.73, 95%CI:1.74-4.27) with model-free approach. For MMP13-77A/G, there was no association between this polymorphism and lung cancer risk in the recessive model(OR = 1.02, 95%CI:0.83-1.26) and with the model-free approach(ORG = 0.95, 95%CI:0.76-1.17). Therefore, this meta-analysis suggests that the MMP1-1607 1G/2G, MMP2-1306 C/T, MMP2-735 C/T, MMP9 -1562 C/T polymorphisms were risk factors for lung cancer among Asians, while MMP13 -77A/G polymorphism was not associated with lung cancer risk.
authors.affiliation: Department of Respiratory Medicine, South Building, Chinese PLA General Hospital, Beijing 100853.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Special Inpatient Unit, Chinese PLA General Hospital, Beijing 100853.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Respiratory Medicine, South Building, Chinese PLA General Hospital, Beijing 100853.
authors.forename: Xuebing
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Respiratory Medicine, Special Inpatient Unit, Chinese PLA General Hospital, Beijing 100853.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Cai
authors.affiliation: Department of Respiratory Medicine, South Building, Chinese PLA General Hospital, Beijing 100853.
authors.forename: Senyang
authors.initials: S
authors.lastname: Yu
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics; D045726:Metalloproteases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis
chemical_list: D045726:Metalloproteases