title: Findings in pancreatic MRI associated with pancreatic fibrosis and HbA1c values.
abstract: OBJECTIVE
  To evaluate the diagnostic performance of noncontrast-enhanced magnetic resonance imaging (MRI) to grade pancreatic fibrosis and to assess hemoglobin (Hb) A1c values.
  
  
  METHODS
  Twenty-nine consecutive patients with pancreatic or biliary malignancy who underwent pancreatectomy were evaluated. Patients were classified into three groups: HbA1c < 5.7 (group 1), 5.7 ≤ HbA1c < 6.5 (group 2), and HbA1c ≥ 6.5 (group 3). MRI of the pancreas was performed using a 1.5T MR system. The pancreas-to-muscle signal intensity ratio (SIR) on in- and opposed-phase T1 -, T2 -, and diffusion-weighted images, as well as the apparent diffusion coefficient were calculated. MRI measurements, degrees of pancreatic fibrosis, and HbA1c values were compared using multiple regression analysis and Kruskal-Wallis test.
  
  
  RESULTS
  The pancreatic fibrosis grade was negatively correlated with the SIR on in-phase T1 -weighted images (r = -0.67, P = 0.0002). The pancreatic fibrosis grade and HbA1c value were negatively correlated with the SIR on opposed-phase T1 -weighted images (r = -0.47, P = 0.019 and r = -0.51, P = 0.0089, respectively). SIRs on in- and opposed-phase T1 -weighted images were significantly lower in group 3 than in groups 1 and 2 (P < 0.05).
  
  
  CONCLUSIONS
  The pancreas-to-muscle SIRs on in- and opposed-phase T1 -weighted images could be a potential biomarker for pancreatic fibrosis and elevated HbA1c values.
authors.affiliation: Department of Radiology, Gifu University Hospital, Gifu, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Noda
authors.affiliation: Department of Radiology, Gifu University Hospital, Gifu, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Goshima
authors.affiliation: Department of Surgical Oncology, Gifu University Hospital, Gifu, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Surgical Oncology, Gifu University Hospital, Gifu, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Osada
authors.affiliation: Department of Tumor Pathology, Gifu University Hospital, Gifu, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tomita
authors.affiliation: Department of Tumor Pathology, Gifu University Hospital, Gifu, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Hara
authors.affiliation: Department of Diabetes and Endocrinology, Gifu University Hospital, Gifu, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Horikawa
authors.affiliation: Department of Diabetes and Endocrinology, Gifu University Hospital, Gifu, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Takeda
authors.affiliation: Department of Radiology Services, Gifu University Hospital, Gifu, Japan.
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Kajita
authors.affiliation: Department of Radiology, Gifu University Hospital, Gifu, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Watanabe
authors.affiliation: Department of Radiology, Gifu University Hospital, Gifu, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawada
authors.affiliation: Department of Radiology, Gifu University Hospital, Gifu, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kawai
authors.affiliation: Department of Radiology, Gifu University Hospital, Gifu, Japan.|Department of Radiology Services, Gifu University Hospital, Gifu, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kanematsu
authors.affiliation: Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
authors.forename: Kyongtae T
authors.initials: KT
authors.lastname: Bae
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005355:Fibrosis; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000473:pathology; D010180:Pancreatectomy; D010182:Pancreatic Diseases / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D011871:Radiology; D012044:Regression Analysis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: HbA1c; magnetic resonance imaging; pancreas; pancreatic fibrosis