title: Comparison of a qualitative measurement of heart-type fatty acid-binding protein with other cardiac markers as an early diagnostic marker in the diagnosis of non-ST-segment elevation myocardial infarction.
abstract: OBJECTIVE
  Heart-type fatty acid-binding protein (H-FABP) is a novel cardiac marker used in the early diagnosis of acute myocardial infarction (AMI), which shows myocyte injury. Our study aimed to compare bedside H-FABP measurements with routine creatine kinase-MB (CK-MB) and troponin I (TnI) tests for the early diagnosis of non-ST-elevation MI (NSTEMI), as well as for determining its exclusion capacity.
  
  
  METHODS
  A total of 48 patients admitted to the emergency room within the first 12 hours of onset of ischaemic-type chest pain lasting more than 30 minutes and who did not have ST-segment elevation on electrocardiography (ECG) were included in the study. Definite diagnoses of NSTEMI were made in 24 patients as a result of 24-hour follow up, and the remaining 24 patients did not develop MI.
  
  
  RESULTS
  When various subgroups were analysed according to admission times, H-FABP was found to be a better diagnostic marker compared to CK-MB and TnI (accuracy index 85%), with a high sensitivity (79%) and specificity (93%) for early diagnosis ( ≤ six hours). The respective sensitivities of bedside H-FABP and TnI tests were 89 vs 33% (p < 0.05) for patients presenting within three hours of onset of symptoms.
  
  
  CONCLUSIONS
  Bedside H-FABP measurements may contribute to correct early diagnoses, as its levels are elevated soon following MI, and measurement is easy, with a rapid result.
authors.affiliation: Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Demet Menekşe
authors.initials: DM
authors.lastname: Gerede
authors.affiliation: Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Sadi
authors.initials: S
authors.lastname: Güleç
authors.affiliation: Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kiliçkap
authors.affiliation: Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Cansin Tulunay
authors.initials: CT
authors.lastname: Kaya
authors.affiliation: Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Veysel Kutay
authors.initials: VK
authors.lastname: Vurgun
authors.affiliation: Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Özgür Ulaş
authors.initials: ÖU
authors.lastname: Özcan
authors.affiliation: Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Göksülük
authors.affiliation: Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Çetin
authors.initials: Ç
authors.lastname: Erol
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D042241:Early Diagnosis; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D000067716:Point-of-Care Testing; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D013997:Time Factors; D019210:Troponin I / Q000097:blood; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D019210:Troponin I; D052279:Creatine Kinase, MB Form