title: [The endothelium of the vessels and proxidative-antioxidative balans in pregnancy rats with endothoxinaemia].
abstract: Actual problem of modern obstetrics is the infection in pregnancy which leads the deadborn, early children's death rate ind disease. In Belarus disease of newborns at specific infections for postnatal the period has made 14.1 per thousand, and death rate of 0.38 per thousand. The purpose of researches--to study a condition endothelium and activity of lipid peroxidation products at pregnant rats with endothoxinaemia. In experiments on 49 pregnancy rats with intramuscular injection of endotoxine (Lipopolysaccharide E. coli Serotype O127:B8 "Sigma") during the period placentation dysfunction development endohelium is established, that was shown more expressed in 2,3 times (p < 0.05) constriction by reaction on noradrenalin, increase in 18,3 times (p < 0.001) quantities circulating endothelium cages and decrease in 14 times (p < 0.001) the deendent endothelium vasodilatation under influence acetilcholine, to the dress increase of level of lipid peroxidation products: concentration of diene conjugates on 91% (p < 0.001), malone dialdegide--on 56% (p < 0.001), Shiff bases--on 7.9% (p < 0.05); and decrease in indicators of antioxidant protection: maintenances retinol on 29% (p < 0.05), α-tocopherol--on 6% (p < 0.001).
authors.forename: T S
authors.initials: TS
authors.lastname: Milosh
authors.lastname: Maksimovich N Ye
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D019446:Endotoxemia / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008315:Malondialdehyde / Q000097:blood; D009638:Norepinephrine / Q000494:pharmacology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D008070:Lipopolysaccharides; D014662:Vasoconstrictor Agents; D008315:Malondialdehyde; D009638:Norepinephrine