title: Myeloid sarcoma of the skin in a patient with myelodysplastic syndrome.
abstract: We report the case of a 76-year-old woman who presented with asymptomatic extensive erythematous. Firm plaques were noted over the right cheek. Complete blood count was normal, as was a peripheral smear. An excision biopsy taken from the cheek showed infiltration of the dermis and hypodermis with atypical cells which were strongly positive for human leukocyte antigen (HLA-DR) and lysozyme and were moderately myeloperoxidase (MPO) enzyme. The results of immunohistochemical staining for CD34, CD117, CD3, CD4, CD8, CD20, CD23, CD56, and ALK-1 were negative. Bone marrow analysis indicated myelodysplastic syndrome RAEB 1 while cytogenetic finding showed tetrasomy 8. It was recommended that the patient undergo local radiotherapy of skin lesions, but she refused and was lost to follow-up.
authors.affiliation: Darko Antic, MD, Clinic for Hematology, Clinical Center Serbia, Koste Todorovića 2, 11000 Belgrade, Serbia; darko.antic1510976@gmail.com.
authors.forename: Darko
authors.initials: D
authors.lastname: Antic
authors.forename: Andrija
authors.initials: A
authors.lastname: Bogdanovic
authors.forename: Maja
authors.initials: M
authors.lastname: Perunicic Jovanovic
authors.forename: Jelica
authors.initials: J
authors.lastname: Jovanovic
authors.forename: Ivo
authors.initials: I
authors.lastname: Elezovic
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D023981:Sarcoma, Myeloid / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology