title: Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System.
abstract: The peroxisome proliferator-activated receptor -γ (PPARγ) has been identified in a wide range of cancers, including brain, breast, colon, stomach and lung cancers. It belongs to the thyroid/ steroid hormone receptors superfamily. Binding with their special ligands, PPARγ plays important roles in regulating transcription of their target genes. PPARγ activation suppresses the growth of the tumor cells, implicating the anti-tumor potential of PPARγ ligand. Tumors in the nervous system are among the most devastating cancers. This review highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in the nervous system.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shen
authors.forename: Yun
authors.initials: Y
authors.lastname: Lu
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Chuntie
authors.initials: C
authors.lastname: Zhu
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301., Middle Yanchang Road, Shanghai 200072, P.R. China. dentist_tracy@hotmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation; D018890:Chemoprevention; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D008024:Ligands; D008527:Medulloblastoma / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D009420:Nervous System / Q000473:pathology*; D009447:Neuroblastoma / Q000473:pathology*; D047495:PPAR gamma / Q000378:metabolism*; D011485:Protein Binding; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D008024:Ligands; D047495:PPAR gamma