title: Impairment of aspirin antiplatelet effects by non-opioid analgesic medication.
abstract: Aspirin is the mainstay in prophylaxis of cardiovascular diseases. Impaired aspirin antiplatelet effects are associated with enhanced incidence of cardiovascular events. Comedication with non-opioid analgesic drugs has been described to interfere with aspirin, resulting in impaired aspirin antiplatelet effects. Additionally, non-opioid analgesic medication has been shown to enhance the risk of cardiovascular events and death. Pain is very frequent and many patients rely on analgesic drugs to control pain. Therefore effective analgesic options without increased risk of cardiovascular events are desirable. This review focuses on commonly used non-opioid analgesics, interactions with aspirin medication and impact on cardiovascular risk.
authors.affiliation: Amin Polzin, Malte Kelm, Tobias Zeus, Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, 40225 Dusseldorf, Germany.
authors.forename: Amin
authors.initials: A
authors.lastname: Polzin
authors.affiliation: Amin Polzin, Malte Kelm, Tobias Zeus, Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, 40225 Dusseldorf, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hohlfeld
authors.affiliation: Amin Polzin, Malte Kelm, Tobias Zeus, Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, 40225 Dusseldorf, Germany.
authors.forename: Malte
authors.initials: M
authors.lastname: Kelm
authors.affiliation: Amin Polzin, Malte Kelm, Tobias Zeus, Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, 40225 Dusseldorf, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Zeus
keywords: Aspirin; Dipyrone; Drug-drug interaction; Metamizole; Non-steroidal anti-inflammatory drug; Paracetamol; Pharmacodynamic