title: Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.
abstract: The human paraoxonase (PON) gene family includes three members: PON1, PON2, and PON3. PON, which prevents the oxidative modification of lipoproteins, has been implicated as a potential risk factor of the cerebrovascular disease. In this study, we investigated associations between coding region single-nucleotide polymorphisms (cSNPs) of PON1, PON2, and PON3 genes and intracerebral hemorrhage (ICH) in a Korean population. Six cSNPs [rs13306698 and rs662 for PON1; rs12026 and rs7493 for PON2; rs13226149 and rs1053275 for PON3] were genotyped using direct sequencing in 145 ICH patients and 372 control subjects. Of the six cSNPs, rs12026 and rs7493, which were in complete linkage disequilibrium, were associated with ICH in log-additive (GC vs. CC vs. GG, p = 0.0008, OR = 0.53, 95 % CI = 0.36-0.78) and dominant models (GC/CC vs. GG, p = 0.0006, OR = 0.47, 95 % CI = 0.30-0.73). In addition, rs13226149 was associated with ICH in log-additive model (GA vs. AA vs. GG, p = 0.0033, OR = 0.58, 95 % CI = 0.39-0.84). In the allele frequency analysis, the C alleles of rs12026 and rs7493 and the A allele of rs13226149 were also shown to contribute to the decreased risk of ICH (p = 0.001, OR = 0.55, 95 % CI = 0.38-0.80 in rs12026 and rs7493; p = 0.003, OR = 0.58, 95 % CI = 0.40-0.83 in rs13226149). These results suggest that PON genes may be involved in the susceptibility of ICH.
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, 130-701, Dongdaemun-gu, Seoul, Republic of Korea.|Department of Emergency Medicine, School of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, 130-701, Dongdaemun-gu, Seoul, Republic of Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, 130-701, Dongdaemun-gu, Seoul, Republic of Korea.
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Park
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, 130-701, Dongdaemun-gu, Seoul, Republic of Korea. jhchung@khu.ac.kr.
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics* / Q000502:physiology; D044466:Asian People / Q000235:genetics*; D002543:Cerebral Hemorrhage / Q000208:ethnology / Q000235:genetics*; D015897:Comorbidity; D020918:Complex Regional Pain Syndromes / Q000208:ethnology; D003920:Diabetes Mellitus / Q000208:ethnology; D050171:Dyslipidemias / Q000208:ethnology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea / Q000453:epidemiology; D012306:Risk
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human; C113656:PON3 protein, human
keywords: Intracerebral hemorrhage; Paraoxonase; Polymorphism