title: Engineering DNA scaffolds for delivery of anticancer therapeutics.
abstract: Engineering DNA nanostructures with programmability in size, shape and surface chemistry holds tremendous promise in biomedical applications. As an emerging platform for drug delivery, DNA nanostructures have been extensively studied for delivering anticancer therapeutics, including small-molecule drug, nucleic acids and proteins. In this mini-review, current advances in utilizing DNA scaffolds as drug carriers for cancer treatment were summarized and future challenges were also discussed.
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA.
authors.forename: Wujin
authors.initials: W
authors.lastname: Sun
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004738:Engineering; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D049329:Nanostructures / Q000737:chemistry* / Q000627:therapeutic use; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy*; D009696:Nucleic Acids / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D009696:Nucleic Acids; D004247:DNA