title: Animal Models of Altered Glucocorticoid Signaling.
abstract: In this chapter we will review genetically engineered mice with alterations in glucocorticoid signaling. Most of the mice involve direct alterations to the glucocorticoid receptor locus, but we will touch briefly on other relevant models including 11-β-HSD transgenics which alter tissue levels of ligand as well as mice with glucocorticoid excess. Of course, the number of mice with mutations in genes such as GR targets and transcriptional coregulators is beyond the scope of this chapter.
authors.affiliation: Division of Endocrinology, Metabolism and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8127, St. Louis, MO, 63110, USA, caharris@dom.wustl.edu.
authors.forename: Charles
authors.initials: C
authors.lastname: Harris
mesh_terms: D000818:Animals; D005938:Glucocorticoids / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D015398:Signal Transduction
chemical_list: D005938:Glucocorticoids