title: Association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function.
  
  
  METHODS
  Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrhosis and determine the Laennec staging system. The association of the Laennec staging system with the degree of cirrhosis, clinical stage and liver function was compared.
  
  
  RESULTS
  The Laennec staging system had a close association with clinical stage, model for end-stage liver disease score and degree of cirrhosis (r = 0.58, p < 0.01; r = 0.60, p < 0.01; r = 0.53, p < 0.01).
  
  
  CONCLUSIONS
  The Laennec histological grading system can to some extent reflect the degree of cirrhosis, clinical stage and liver function, and is expected to predict the incidence of patient complications in a useful way.
authors.affiliation: Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. w_w824@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Jiye
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Runhua
authors.initials: R
authors.lastname: Pan
authors.affiliation: Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Sileng
authors.initials: S
authors.lastname: A
authors.affiliation: Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. liaocx@fimmu.com.
authors.forename: Caixian
authors.initials: C
authors.lastname: Liao
mesh_terms: D000328:Adult; D001706:Biopsy; D003094:Collagen / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D003094:Collagen
keywords: Cirrhosis; Clinical stage; Collagen; Pathological grading