title: Incidence of major smoking-related cancers: trends among adults aged 20-44 in France from 1982 to 2012.
abstract: BACKGROUND
  Tobacco is currently the largest risk factor for cancers of the lung, lip/oral cavity/pharynx (LOCP) and esophagus. Variations in tobacco consumption over time have led to changes in cancer incidence in the general population. Data on the incidence of cancers at these sites in adults aged 20-44 years old are scarce. Our objective was to provide estimates of incidence trends for these cancers in France among this age group over the last 30 years.
  
  
  METHODS
  Observed incidence data over the period 1982-2010 for the 20-44 age group were provided from six cancer registries (eight for esophagus) covering approximately 6% of the French population. Age-period-cohort models were used on the observed period, and estimates of cancer incidence for France in 2012 were provided on the basis of short-term predictions.
  
  
  RESULTS
  In men, a sharp decline was observed over time for LOCP and esophageal cancers, while lung cancer saw only a slight decline. In women, a large increase was seen in lung cancer incidence, while LOCP cancer incidence did not vary significantly.
  
  
  CONCLUSIONS
  Smoking behaviors among adults aged 20-44 impact incidence trends in cancers of the lung, LOCP and esophagus, although other factors are involved, particularly in LOCP and esophageal cancers. Our results highlight the importance of preventative efforts which particularly target women aged 20-44. Efforts to curb tobacco smoking in men should also be pursued.
authors.affiliation: Institut de Veille Sanitaire, Département des Maladies Chroniques et Traumatismes, 12 rue du val d'Osne, 94410 Saint Maurice, France; Hospices Civils de Lyon, Service de Biostatistique, F-69003, Lyon, France; Université de Lyon, F-69000, Lyon, France; Université Lyon 1, F-69100, Villeurbanne, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Gilhodes
authors.affiliation: Institut de Veille Sanitaire, Département des Maladies Chroniques et Traumatismes, 12 rue du val d'Osne, 94410 Saint Maurice, France; Hospices Civils de Lyon, Service de Biostatistique, F-69003, Lyon, France; Université de Lyon, F-69000, Lyon, France; Université Lyon 1, F-69100, Villeurbanne, France; CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Sante, F-69100, Villeurbanne, France; Cancer Research UK Cancer Survival Group, Faculty of Epidemiology and Population Health, Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, Keppel St, London WC1E 7HT, UK.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Belot
authors.affiliation: Francim, Réseau francais des registres des cancers, Francim, F-31073 Toulouse, France; Registre Bourguignon des Cancers Digestifs INSERM U866, CHU Dijon, Université de Dijon, Faculté de Médecine, Dijon, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Bouvier
authors.affiliation: Hospices Civils de Lyon, Service de Biostatistique, F-69003, Lyon, France; Université de Lyon, F-69000, Lyon, France; Université Lyon 1, F-69100, Villeurbanne, France; CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Sante, F-69100, Villeurbanne, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Remontet
authors.affiliation: Francim, Réseau francais des registres des cancers, Francim, F-31073 Toulouse, France; Registre du cancer du département de l'Isere, CHU de Grenoble, F-38000 Grenoble, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Delafosse
authors.affiliation: Francim, Réseau francais des registres des cancers, Francim, F-31073 Toulouse, France; Registre général des cancers de Lille et de sa région, F-59120 Loos, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Ligier
authors.affiliation: Institut de Veille Sanitaire, Département des Maladies Chroniques et Traumatismes, 12 rue du val d'Osne, 94410 Saint Maurice, France. Electronic address: a.rogel@invs.sante.fr.
authors.forename: Agnès
authors.initials: A
authors.lastname: Rogel
mesh_terms: D000328:Adult; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D012042:Registries; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D055815:Young Adult
keywords: Cancer; Cancer registry; Epidemiology; Incidence; Smoking; Young adults