title: Metabolic Syndrome and Aging: Calcium Signaling as Common Regulator.
abstract: Aging is one of the most important societal challenges that western societies face, as a result of longer life expectancy and reduced natality rates. Aging is a success story of our health and social systems, but raises sustainability issues that are linked to the increased need for services of older adults, due to the reduction of their independence and to the co-existence of multiple chronic diseases. The metabolic syndrome can be considered an age-related disease, since its prevalence increases with age. Current demographic trends in the population highlight aging-related dysfunctions that contribute to the onset of several metabolic diseases, and the need for innovative, effective and sustainable approaches. This review describes the correlation between the metabolic syndrome and aging, and the underlying common molecular mechanisms, focusing on calcium signaling and its crosstalks.
authors.forename: Maria
authors.initials: M
authors.lastname: Soprano
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Rusciano
authors.forename: Michele
authors.initials: M
authors.lastname: Ciccarelli
authors.forename: Angela Serena
authors.initials: AS
authors.lastname: Maione
authors.forename: Pietro
authors.initials: P
authors.lastname: Formisano
authors.affiliation: Department of Translational Medical Science, University of Naples Federico II, and AOU Federico II, via S. Pansini5, 80131, Naples, Italy. illario@unina.it.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Illario
mesh_terms: D000368:Aged; D000375:Aging; D020013:Calcium Signaling; D006801:Humans; D008017:Life Expectancy; D024821:Metabolic Syndrome / Q000503:physiopathology*; D012307:Risk Factors