title: Flat cells come full sphere: Are mutant cytoskeletal-related proteins oncoprotein-monsters or useful immunogens?
abstract: Osteogenesis imperfecta is inherited as a dominant disease because if one allele is mutated, it contributes a mutant, destructive subunit polypeptide to collagen, which requires many subunits to form normal, polymeric, collagenous structures. Recent cancer genome atlas (TCGA) data indicate that cytoskeletal-related proteins are among the most commonly mutated proteins in human cancers, in distinct mutation frequency groups, i.e., including low mutation frequency groups. Part of the explanation for this observation is likely to be the fact that many of the coding regions for these proteins are very large, and indeed, it is likely these coding regions are mutated in many cells that never become cancerous. However, it would not be surprising if mutations in cytoskeletal proteins, when combined with oncoprotein or tumor suppressor protein mutations, had significant impacts on cancer development, for a number of reasons, including results obtained almost 5 decades ago indicating that well-spread cells in tissue culture, with well-formed cytoskeletons, were less tumorigenic than spherical cells with disrupted cytoskeletons. This raises the question, are mutant cytoskeletal proteins, which would likely interfere with polymer formation, a new class of oncoproteins, in particular, dominant negative oncoproteins? If these proteins are so commonly mutant, could they be the bases for common cancer vaccines?
authors.affiliation: a Department of Molecular Medicine ; Morsani College of Medicine; University of South Florida ; Tampa , FL USA.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Parry
authors.affiliation: a Department of Molecular Medicine ; Morsani College of Medicine; University of South Florida ; Tampa , FL USA.|b Immunology Program; Moffitt Cancer Center and Research Institute ; Tampa , FL USA.
authors.forename: George
authors.initials: G
authors.lastname: Blanck
mesh_terms: D000941:Antigens / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D050505:Mutant Proteins / Q000235:genetics / Q000276:immunology*; D015513:Oncogene Proteins / Q000276:immunology*
chemical_list: D000941:Antigens; D019496:Cancer Vaccines; D003598:Cytoskeletal Proteins; D050505:Mutant Proteins; D015513:Oncogene Proteins
keywords: Oncoprotein, cancer immunology, cytoskeleton, extra-cellularmatrix, revertants, spheroid cells, dominant negative