title: Comparison of energy expenditure, body composition, metabolic disorders, and energy intake between obese children with a history of craniopharyngioma and children with multifactorial obesity.
abstract: Craniopharyngioma is a histologically benign brain malformation with a fundamental role in satiety modulation, causing obesity in up to 52% of patients.
  
  
  OBJECTIVE
  To evaluate cardiovascular risk factors, body composition, resting energy expenditure (REE), and energy intake in craniopharyngioma patients and to compare the data with those from children with multifactorial obesity.
  
  
  METHODS
  All obese children and adolescents who underwent craniopharyngioma resection and a control group of children with multifactorial obesity in follow-up between May 2012 and April 2013.
  
  
  METHODS
  Anthropometric measurements, bioelectrical impedance, indirect calorimetry, energy intake, homeostatic model assessment insulin resistance (HOMA-IR), and dyslipidemia were evaluated.
  
  
  RESULTS
  Twenty-three patients with craniopharyngioma and 43 controls were included. Children with craniopharyngioma-related obesity had a lower fat-free mass percentage (62.4 vs. 67.5; p=0.01) and a higher fat mass percentage (37.5 vs. 32.5; p=0.01) compared to those with multifactorial obesity. A positive association was found between %REE and %fat-free mass in subjects with multifactorial obesity (68±1% in normal REE vs. 62.6±1% in low REE; p=0.04), but not in craniopharyngioma patients (62±2.7 in normal REE vs. 61.2±1.8% in low REE; p=0.8). No differences were found in metabolic involvement or energy intake.
  
  
  CONCLUSIONS
  REE was lower in craniopharyngioma patients compared to children with multifactorial obesity regardless of the amount of fat-free mass, suggesting that other factors may be responsible for the lower REE.
authors.forename: Ilanit
authors.initials: I
authors.lastname: Bomer
authors.forename: Carola
authors.initials: C
authors.lastname: Saure
authors.forename: Carolina
authors.initials: C
authors.lastname: Caminiti
authors.forename: Javier Gonzales
authors.initials: JG
authors.lastname: Ramos
authors.forename: Graciela
authors.initials: G
authors.lastname: Zuccaro
authors.forename: Mercedes
authors.initials: M
authors.lastname: Brea
authors.forename: Mónica
authors.initials: M
authors.lastname: Bravo
authors.forename: Carmen
authors.initials: C
authors.lastname: Maza
mesh_terms: D000293:Adolescent; D001823:Body Composition / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000150:complications / Q000378:metabolism*; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism*; D055815:Young Adult