title: Environmental manipulation affects depressive-like behaviours in female Wistar-Kyoto rats.
abstract: While the efficacy of pharmacological interventions to treat depression has been well-studied in animal models, much less work has been done to shed light on how changes in the immediate environment can impact behaviour. Furthermore, most studies have focused on male rodents despite the prevalence of mood disorders in women. In this study, 36 Wistar Kyoto (validated animal model of depression) and 36 Wistar (control) female rats were used to examine the effects of environmental manipulation on depressive- and anxiety-like behaviours. Animals were assigned to one of three groups: standard (3 rats/cage), enriched (6 rats/cage plus physical enrichment), and isolation (1 rat/cage) housing. The elevated plus maze (EPM) and forced swim test (FST) were conducted prior to, and four weeks after environmental assignment to measure anxiety-like and depressive-like behaviours, respectively. Sucrose preference assessed anhedonia both before and after environmental assignment. Weight was measured every week to monitor weight-gain over time. Post-environment sucrose preference was significantly increased in animals in enriched housing as compared to those in isolated housing in both strains. While there were significant differences between strains in measures of open arm duration in the EPM and immobility in the FST, there appeared to be no differences between environmental groups. The results of this study highlight the importance of environmental factors in the expression of anhedonia. Enrichment appears to reduce anhedonia while isolation increases anhedonia. These effects should be studied further to assess whether longer periods of social and physical enrichment alleviate other symptoms of depression.
authors.affiliation: University of Ottawa, School of Psychology, Behavioural Neuroscience Group, 136 Jean-Jacques Lussier, Ottawa, Ontario K1N 6N5, Canada. Electronic address: gerrimileva@gmail.com.
authors.forename: Guergana R
authors.initials: GR
authors.lastname: Mileva
authors.affiliation: University of Ottawa, School of Psychology, Behavioural Neuroscience Group, 136 Jean-Jacques Lussier, Ottawa, Ontario K1N 6N5, Canada.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bielajew
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000502:physiology; D003863:Depression / Q000451:nursing* / Q000503:physiopathology / Q000523:psychology; D004195:Disease Models, Animal; D004777:Environment; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D005518:Food Preferences / Q000502:physiology; D018782:Maze Learning; D051381:Rats; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D012934:Social Isolation / Q000523:psychology*; D013045:Species Specificity; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D013550:Swimming / Q000523:psychology
chemical_list: D013549:Sweetening Agents; D013395:Sucrose
keywords: Anxiety; Depression; Environmental enrichment; Isolation; Sucrose preference; Wistar-Kyoto