title: Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates.
abstract: A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed. PAPM-lipids and PAPG-lipids conjugates were also synthesized for targeting drugs to receptors. A binding inhibition study of synthesized p-(dimethylamino butylamido) phenyl-α-d-mannopyranoside (1a) with Concanavalin A was performed using invertase enzyme. In addition, transfection of pSV-β-gal reporter gene with was investigated in A549 cells.
authors.affiliation: Jina Pharmaceuticals, Inc., 28100 N. Ashley Circle, Suite 103, Libertyville, IL 60048, USA.
authors.forename: Moghis U
authors.initials: MU
authors.lastname: Ahmad
authors.affiliation: Jina Pharmaceuticals, Inc., 28100 N. Ashley Circle, Suite 103, Libertyville, IL 60048, USA.
authors.forename: Shoukath M
authors.initials: SM
authors.lastname: Ali
authors.affiliation: Jina Pharmaceuticals, Inc., 28100 N. Ashley Circle, Suite 103, Libertyville, IL 60048, USA.
authors.forename: Ateeq
authors.initials: A
authors.lastname: Ahmad
authors.affiliation: Jina Pharmaceuticals, Inc., 28100 N. Ashley Circle, Suite 103, Libertyville, IL 60048, USA.
authors.forename: Saifuddin
authors.initials: S
authors.lastname: Sheikh
authors.affiliation: Nia Life Sciences, 28100 N. Ashley Circle, Suite 102, Libertyville, IL 60048, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Chen
authors.affiliation: Jina Pharmaceuticals, Inc., 28100 N. Ashley Circle, Suite 103, Libertyville, IL 60048, USA.
authors.forename: Imran
authors.initials: I
authors.lastname: Ahmad