title: Increased IL-3 serum levels in chronic patients with schizophrenia: Associated with psychopathology.
abstract: Schizophrenia is associated with the inflammation-related pathways, including aberrant cytokines levels. In this study, we examined the association of serum IL-3 levels with psychopahological symtoms in chronic schizophrenia. Serum IL-3 levels were assessed in 42 patients diagnosed with schizophrenia and compared to 43 healthy control subjects matched for age and gender. Schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS), and serum IL-3 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). Our results showed that IL-3 levels were significantly increased in patients with chronic schizophrenia compared to healthy control subjects. Correlation analysis revealed a significant positive correlation between the IL-3 levels and the PANSS general subscore. Moreover, IL-3 levels were significantly positively correlated with depressive subscore. Our results suggested that IL-3 related pathway is associated with psychopathology of schizophrenia patients.
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Mei Hong
authors.initials: MH
authors.lastname: Xiu
authors.affiliation: Wenzhou Seventh People's Hospital, Wenzhou, China.
authors.forename: Chong Guang
authors.initials: CG
authors.lastname: Lin
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China; Neuroscience Center, Viikinkaari 4, FIN-00014, University of Helsinki, Helsinki, Finland.
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Yun Long
authors.initials: YL
authors.lastname: Tan
authors.affiliation: School of Medical and Health Management, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Shu Ping
authors.initials: SP
authors.lastname: Tan
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Zhi Ren
authors.initials: ZR
authors.lastname: Wang
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Fu De
authors.initials: FD
authors.lastname: Yang
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Da Chun
authors.initials: DC
authors.lastname: Chen
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, China; Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: xiang.y.zhang@uth.tmc.edu.
authors.forename: Xiang Yang
authors.initials: XY
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003866:Depressive Disorder / Q000175:diagnosis / Q000276:immunology / Q000523:psychology; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011599:Psychopathology; D012559:Schizophrenia / Q000175:diagnosis / Q000276:immunology*; D012565:Schizophrenic Psychology; D013223:Statistics as Topic
chemical_list: D007377:Interleukin-3
keywords: Cytokines; Immune system; Interleukin-3; Psychopathology; Schizophrenia