title: Evaluation of Anti-Inflammatory Effects of Curcumin Gel as an Adjunct to Scaling and Root Planing: A Clinical Study.
abstract: BACKGROUND
  Complete removal of irritants is not possible with mechanical therapy alone. Adjunctive use of systemic administration of antibiotics results in the distribution of drug throughout the body, which can give rise to toxicity. Curcumin (diferuloylmethane), a constituent of Curcuma longa plant, which possess antioxidant, anti-inflammatory, anti-carcinogenic, anti-microbial, anti-hyper algesic and hypocholesterolemic properties. The aim of the present study is to compare the effects of the curcumin gel as an adjunct to subgingival scaling and root planning with the effect achieved using subgingival scaling and root planning alone.
  
  
  METHODS
  Thirty patients either male or female with chronic localized or generalized periodontitis aged between 25 and 60 years with pocket depth of 5-7 mm affecting at least two nonadjacent sites were included. In the experimental site scaling and root planning was performed, followed by placement of the curcumin gel and periodontal pack application. In the control site, subgingival scaling alone was performed followed by periodontal pack application. Parameters included were: Plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment loss. These parameters were recorded on day 0, 30 and 45 days.
  
  
  RESULTS
  Significant reduction in mean was observed in PI, GI, PD and gain in clinical attachment level were demonstrated in both the groups from baseline to 45 days. However, statistical significant reduction was observed in PI at baseline and 30(th) day and GI at 30(th) day.
  
  
  CONCLUSIONS
  Curcumin can be effectively used along with scaling and root planning. Future research is required to determine the long-term effects of curcumin on a large sample of subjects.
authors.affiliation: Professor and Head, Department of Periodontics, MNR Dental College & Hospital, Sangareddy, Medak, Telangana, India.
authors.forename: B R
authors.initials: BR
authors.lastname: Anuradha
authors.affiliation: Professor, Department of Periodontics, Government Dental College & Hospital, Hyderabad, India.
authors.forename: Yendluri Durga
authors.initials: YD
authors.lastname: Bai
authors.affiliation: Associate Professor, Department of Oral Medicine & Radiology, Government Dental College & Hospital, Hyderabad, India.
authors.forename: Sambhana
authors.initials: S
authors.lastname: Sailaja
authors.affiliation: Reader, Department of Periodontics, G. Pullareddy Dental College & Hospital, Kurnool, Andhra Pradesh, India.
authors.forename: Jaradoddi
authors.initials: J
authors.lastname: Sudhakar
authors.affiliation: Post Graduate Student, Department of Periodontics, MNR Dental College & Hospital, Sangareddy, Medak, Telangana, India.
authors.forename: M
authors.initials: M
authors.lastname: Priyanka
authors.affiliation: Post Graduate Student, Department of Periodontics, MNR Dental College & Hospital, Sangareddy, Medak, Telangana, India.
authors.forename: V
authors.initials: V
authors.lastname: Deepika
keywords: Antioxidant; curcumin; sub gingival scaling and root planning