title: Pharmacokinetic digital phantoms for accuracy assessment of image-based dosimetry in (177)Lu-DOTATATE peptide receptor radionuclide therapy.
abstract: Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms corresponding to patients treated with (177)Lu-DOTATATE. Three individual voxel phantoms from the XCAT population were generated and assigned a dynamic activity distribution based on a compartment model for (177)Lu-DOTATATE, designed specifically for this purpose. The compartment model was fitted to time-activity data from 10 patients, primarily acquired using quantitative scintillation camera imaging. S values for all phantom source-target combinations were calculated based on Monte-Carlo simulations. Combining the S values and time-activity curves, reference values of the absorbed dose to the phantom kidneys, liver, spleen, tumours and whole-body were calculated. The phantoms were used in a virtual dosimetry study, using Monte-Carlo simulated gamma-camera images and conventional methods for absorbed-dose calculations. The characteristics of the SPECT and WB planar images were found to well represent those of real patient images, capturing the difficulties present in image-based dosimetry. The phantoms are expected to be useful for further studies and optimisation of clinical dosimetry in (177)Lu PRRT.
authors.affiliation: Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Sweden.
authors.forename: Gustav
authors.initials: G
authors.lastname: Brolin
authors.forename: Johan
authors.initials: J
authors.lastname: Gustafsson
authors.forename: Michael
authors.initials: M
authors.lastname: Ljungberg
authors.forename: Katarina Sjögreen
authors.initials: KS
authors.lastname: Gleisner
mesh_terms: D015282:Octreotide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use*; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011881:Radiotherapy, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D012588:Scintillation Counting / Q000295:instrumentation / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C447941:lutetium Lu 177 dotatate; D015282:Octreotide