title: Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus.
abstract: OBJECTIVE
  To investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies.
  
  
  METHODS
  This study included 200 pregnant women. 25-hydroxyvitamin D3(25(OH)D3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D3 level in different MPV percentile (≤ 50, 50-75, 75-90, ≥ 90 percentile) and MPV value in different 25(OH)D3 level (≤ 10, 10-20, ≥ 20 ng/mL) were calculated.
  
  
  RESULTS
  Low 25(OH)D3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D3 level in GMD group (p = 0.04). The optimal 25(OH)D3 cut off point for predicting future cardiovascular risk was 10.4 ng/ mL (area under curve (AUC) = 0.58).
  
  
  CONCLUSIONS
  Vitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Esra Bahar
authors.initials: EB
authors.lastname: Gur
authors.affiliation: Department of Endocrinology, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Karadeniz
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Genc
authors.affiliation: Obstetrics and Gynecology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Eskicioglu
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Yalcin
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Irem
authors.initials: I
authors.lastname: Hepyilmaz
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Guclu
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000517:prevention & control; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D063847:Mean Platelet Volume; D011247:Pregnancy; D012372:ROC Curve; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D