title: Coupled Stable Overlapping Replicator Dynamics for Multimodal Brain Subnetwork Identification.
abstract: Combining imaging modalities to synthesize their inherent strengths provides a promising means for improving brain subnetwork identification. We propose a multimodal integration technique based on a sex-differentiated formulation of replicator dynamics for identifying subnetworks of brain regions that exhibit high inter-connectivity both functionally and structurally. Our method has a number of desired properties, namely, it can operate on weighted graphs derived from functional magnetic resonance imaging (tMRI) and diffusion MRI (dMRI) data, allows for subnetwork overlaps, has an intrinsic criterion for setting the number of subnetworks, and provides statistical control on false node inclusion in the identified subnetworks via the incorporation of stability selection. We thus refer to our technique as coupled stable overlapping replicator dynamics (CSORD). On synthetic data, We demonstrate that CSORD achieves significantly higher subnetwork identification accuracy than state-of-the-art techniques. On real. data from the Human Connectome Project (HCP), we show that CSORD attains improved test-retest reliability on multiple network measures and superior task classification accuracy.
authors.forename: Burak
authors.initials: B
authors.lastname: Yoldemir
authors.forename: Bernard
authors.initials: B
authors.lastname: Ng
authors.forename: Rafeef
authors.initials: R
authors.lastname: Abugharbieh
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D063132:Connectome / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods*; D009415:Nerve Net / Q000033:anatomy & histology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D012680:Sensitivity and Specificity; D013382:Subtraction Technique