title: Prevalence and Risk Factors for the Peripheral Neuropathy in Patients with Peripheral Arterial Occlusive Disease.
abstract: OBJECTIVE
  Peripheral neuropathy (PN) is known as a major contributor of the worsening of ischemic symptoms and the foot ulceration in patients with peripheral arterial occlusive disease (PAOD). However, there are few studies reporting the prevalence and risk factors for PN in PAOD. This study aimed to evaluate these issues for PN and to establish the importance of screening as additional treatment target for PN in PAOD.
  
  
  METHODS
  A total of 52 limbs with PAOD were enrolled from January 2011 to December 2012. PN was divided into radiculopathy, ischemic PN (IPN), and diabetic PN (DPN), based on electromyographic findings. We investigated the prevalence of overall PN and subtypes of PN and then analyzed the risk factors.
  
  
  RESULTS
  The prevalence of overall PN in PAOD was 43 of 52 limbs (82.7%). In terms of subtypes of PN, the prevalence rate of radiculopathy and IPN was 30.8% and 23.1%, respectively. DPN showed in 22 limbs (73.3%) among 30 diabetic limbs. There was no significant correlation between each type of PN and ischemic symptoms. Our analysis showed that coronary artery disease (CAD) was a significant risk factor (P=0.01) for IPN, however, did not identify any significant risk factors for DPN.
  
  
  CONCLUSIONS
  This present study indicated that most patients with PAOD had PN and CAD was a risk factor for IPN. In particular, PAOD with diabetes represented a higher prevalence for DPN. Our study suggests that PN should be evaluated and considered as another treatment target in patients with PAOD.
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Young Ae
authors.initials: YA
authors.lastname: Kim
authors.affiliation: Rehabilitation Medicine, Seoul Medical Center, Seoul, Korea.
authors.forename: Eun Su
authors.initials: ES
authors.lastname: Kim
authors.affiliation: Radiology, Seoul Medical Center, Seoul, Korea.
authors.forename: Ho Kyeong
authors.initials: HK
authors.lastname: Hwang
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Kyung Bok
authors.initials: KB
authors.lastname: Lee
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Sol
authors.initials: S
authors.lastname: Lee
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Ji Woong
authors.initials: JW
authors.lastname: Jung
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Yu Jin
authors.initials: YJ
authors.lastname: Kwon
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Dong Hui
authors.initials: DH
authors.lastname: Cho
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Sang Su
authors.initials: SS
authors.lastname: Park
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Jin
authors.initials: J
authors.lastname: Yoon
authors.affiliation: Departments of Surgery, Seoul Medical Center, Seoul, Korea.
authors.forename: Yong-Seog
authors.initials: YS
authors.lastname: Jang
keywords: Peripheral; Peripheral arterial occlusive disease; Prevalence; Risk factor; neuropathy