title: Evaluation of Lean Body Weight Equation by Dual-Energy X-Ray Absorptiometry Measures.
abstract: When managing patients with disorders that require clinical intervention, a practical assessment of body habitus is valued. The Duffull-Green lean body weight (LBW) equation was derived and validated in adults across a wide body mass index (BMI) range. Whether this predictive equation will perform well in patients at BMI extremes or perform better than a widely used empiric "ideal" body weight (IBW) equation is unknown.
  
  
  
  Calculated LBW and calculated IBW were each compared with the dual-energy x-ray absorptiometry (DXA)-derived lean body mass (LBM) by simple linear regression. A mixed model was used to determine how well the LBW equation performed over time in patients with more than 1 DXA measurement.
  
  
  
  At time 0, 32 patients were 18-67 years old, and all were obese (BMI: 36-65 kg/m2), while the remaining 7 had parenteral nutrition-dependent intestinal failure (BMI: 17-25 kg/m2). A subset of patients underwent bariatric surgery after time 0 (BMI at follow-up: 22-49 kg/m2). The LBW equation was a predictor of LBM ( R2= 0.67, P < .0001), while the IBW equation was not ( R2= 0.04, P = .25). The LBW equation remained a predictor of LBM over time ( P < .0001) without significant interaction by number of months since time 0.
  
  
  
  The Duffull-Green LBW equation successfully predicted lean body mass in a patient population with a wide range of BMIs at both a single point in time and after considerable weight loss. In the clinical setting, an equation that performs well in various disease states and body sizes is advantageous.
authors.affiliation: 1 Department of Food Science and Nutrition, University of Minnesota, St Paul, Minnesota, USA.|2 Swedish Medical Center-Food and Nutrition Services, Englewood, Colorado, USA.
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Beckman
authors.affiliation: 3 Department of Biobehavioral & Health Sciences, University of Pennsylvania, Philadelphia, USA.
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Boullata
authors.affiliation: 3 Department of Biobehavioral & Health Sciences, University of Pennsylvania, Philadelphia, USA.
authors.forename: Paige L
authors.initials: PL
authors.lastname: Fisher
authors.affiliation: 3 Department of Biobehavioral & Health Sciences, University of Pennsylvania, Philadelphia, USA.
authors.forename: Charlene W
authors.initials: CW
authors.lastname: Compher
authors.affiliation: 1 Department of Food Science and Nutrition, University of Minnesota, St Paul, Minnesota, USA.
authors.forename: Carrie P
authors.initials: CP
authors.lastname: Earthman
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D008910:Minnesota; D009765:Obesity / Q000601:surgery / Q000628:therapy; D016331:Parenteral Nutrition, Home; D010414:Pennsylvania; D055815:Young Adult
keywords: adult; body composition; nutrition; nutrition assessment