title: Experiences with CPP-Based Self Assembling Peptide Systems for Topical Delivery of Botulinum Toxin.
abstract: Considerations in rational designs of CPP-based transcutaneous delivery systems are described. Impact of design considerations of nonclinical and clinical results are presented in detail.
authors.affiliation: Revance Therapeutics Inc., 7555 Gateway Blvd, Newark, CA, 94560, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: Lee
authors.forename: Phil
authors.initials: P
authors.lastname: Kennedy
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Waugh
mesh_terms: D065087:Acetylcholine Release Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D000279:Administration, Cutaneous; D000595:Amino Acid Sequence; D000818:Animals; D001905:Botulinum Toxins / Q000008:administration & dosage* / Q000627:therapeutic use; D057846:Cell-Penetrating Peptides / Q000009:adverse effects / Q000737:chemistry*; D004337:Drug Carriers / Q000009:adverse effects / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy; D008969:Molecular Sequence Data; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D065087:Acetylcholine Release Inhibitors; D057846:Cell-Penetrating Peptides; D004337:Drug Carriers; D001905:Botulinum Toxins