title: Combined Multimodal Computed Tomography Score Correlates With Futile Recanalization After Thrombectomy in Patients With Acute Stroke.
abstract: OBJECTIVE
  Futile recanalization after acute ischemic stroke occurs in almost half of the patients despite optimal angiographic results. Multimodal neuroimaging may help to improve patient's selection but is still dismissed by many interventionalists. Our aim was to evaluate the accuracy of each parameter of multimodal computed tomography (CT) and their combination for predicting futile recanalization after successful thrombectomy.
  
  
  METHODS
  We retrospectively reviewed a cohort of consecutive patients with anterior circulation stroke, fully assessable multimodal CT, and successful recanalization. Nonenhanced CT, CT angiography source images, cerebral blood volume (CBV), cerebral blood flow (CBF), and mismatch CBV-CBF maps were studied by Alberta Stroke Program Early CT Score (ASPECTS); collaterals on CT angiography were graded as poor or good (≤50% or >50% of the middle cerebral artery territory). Futile recanalization was defined as modified Rankin Scale score >2 at 3 months despite successful recanalization.
  
  
  RESULTS
  One hundred fifty patients were included and 57% of them had futile recanalization. They had lower ASPECTS on nonenhanced CT, CT angiography source images, CBV, CBF, and mismatch CBV-CBF and presented more frequently poor collaterals (all P<0.001). Among them, CBV showed the highest area under the curve (0.83; 95% confidence interval, 0.76-0.88). In multivariate analyses, CT angiography source images ≤5 (odds ratio, 5.1; 95% confidence interval, 1.2-21.9), CBV≤6 (odds ratio, 3.5; 95% confidence interval, 1.2-9.7), and poor collaterals (odds ratio, 8.6; 95% confidence interval, 1.8-41.7) were independent predictors of futile recanalization. A combined score of these 3 parameters added complementary information: 57% of the patients with score-1, 89% with score-2, and 100% with score-3 had futile recanalization. Reclassification analyses indicated that this score improved prediction of futile recanalization.
  
  
  CONCLUSIONS
  In this population, a combined multimodal CT score predicted futile recanalization.
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.). mm.espinosa@gmail.com.
authors.forename: Mariano
authors.initials: M
authors.lastname: Espinosa de Rueda
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Guillermo
authors.initials: G
authors.lastname: Parrilla
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Sergio
authors.initials: S
authors.lastname: Manzano-Fernández
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Blanca
authors.initials: B
authors.lastname: García-Villalba
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Joaquín
authors.initials: J
authors.lastname: Zamarro
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Francisco
authors.initials: F
authors.lastname: Hernández-Fernández
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Cristina
authors.initials: C
authors.lastname: Sánchez-Vizcaino
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Ester
authors.initials: E
authors.lastname: Carreón
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Ana
authors.initials: A
authors.lastname: Morales
authors.affiliation: From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
authors.forename: Antonio
authors.initials: A
authors.lastname: Moreno
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D018447:Medical Futility; D008875:Middle Aged; D064847:Multimodal Imaging; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012720:Severity of Illness Index; D020521:Stroke / Q000000981:diagnostic imaging* / Q000601:surgery*; D017131:Thrombectomy / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: angiography; multimodal imaging; stroke; thrombectomy; tomography