title: Monoamine Oxidase A gene polymorphisms and self reported aggressive behaviour in a Pakistani ethnic group.
abstract: OBJECTIVE
  To investigate the association of monoamine oxidase Agene polymorphisms with aggression.
  
  
  METHODS
  The study was conducted in an ethnic community in Lahore, Pakistan, from August 2008 to December 2009 on the basis of data that was collected through a questionnaire between August 2004 and September 2005. It analysed 10 single nucleotide polymorphisms of monoamine oxidase A in unrelated males from the same ethnic background who were administered a Punjabi translation of the Buss and Perry aggression questionnaire. SPSS 13 was used for statistical analysis.
  
  
  RESULTS
  Of the total 133 haplotypes studied, 52(39%) were Haplotype A, 58(43.6%) B, 8(6%) C, 3(2.3%) D, 9(6.8%) E and 3(2.3%) F. The six haplotypes were analysed for association with scores of the four subscales of the aggression questionnaire and multivariate analysis of variance showed no significant differences (p>0.05 each) in the error variances of the total scores and scores for three of the sub-scales across the haplotypes. The variance was significantly different only for the anger sub-scale (p<0.05).
  
  
  CONCLUSIONS
  The association of an extended haplotype with low levels of self-reported aggression in this study should assist in characterisation of functional variants responsible for non-aggressive behaviour in male subjects.
authors.affiliation: Section of Forensic Medicine, Sindh Institute of Urology and Transplantation, Karachi.
authors.forename: Syed Shoaib
authors.initials: SS
authors.lastname: Shah
authors.affiliation: Section of Biochemistry, Shifa College of Medicine, ShifaTameer-e-Millat University, Islamabad.
authors.forename: Aisha
authors.initials: A
authors.lastname: Mohyuddin
authors.affiliation: Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso", Naples, Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Colonna
authors.affiliation: Centre for Human Genetics, Sindh Institute of Urology and Transplantation, Karachi.
authors.forename: Syed Qasim
authors.initials: SQ
authors.lastname: Mehdi
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.
authors.forename: Qasim
authors.initials: Q
authors.lastname: Ayub
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000374:Aggression / Q000502:physiology*; D000786:Anger / Q000502:physiology*; D006239:Haplotypes; D006791:Hostility; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D010154:Pakistan; D020641:Polymorphism, Single Nucleotide; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
keywords: Aggression, Behaviour, Behavioural Genetics, MAOA