title: Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain.
abstract: Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies available are either ineffective or non-specific thus requiring newer treatment approaches. In this study, we investigated the antiallodynic and antihyperalgesic effects of zerumbone, a bioactive sesquiterpene from Zingiber zerumbet in chronic constriction injury (CCI)-induced neuropathic pain animal model. Our findings showed that single and repeated dose of intra-peritoneal administration of zerumbone (5, 10, 50, 100 mg/kg) significantly attenuated the CCI-induced neuropathic pain when evaluated using the electronic von Frey anesthesiometer, cold plate, Randall-Selitto analgesiometer and the Hargreaves plantar test. Zerumbone significantly alleviated tactile and cold allodynia as well as mechanical and thermal hyperalgesia. Our findings are in comparison to the positive control drugs thatused gabapentin (20 mg/kgi.p.) and morphine (1 mg/kgi.p.). Together, these results showed that the systemic administration of zerumbone produced marked antiallodynic and antihyperalgesic effects in the CCI-induced neuropathic pain in mice and may serve as a potential lead compound for further analysis.
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Nurul Atiqah
authors.initials: NA
authors.lastname: Zulazmi
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Banulata
authors.initials: B
authors.lastname: Gopalsamy
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Ahmad Akira Omar
authors.initials: AA
authors.lastname: Farouk
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Mohd Roslan
authors.initials: MR
authors.lastname: Sulaiman
authors.affiliation: Biomedical Science Programme, School of Diagnostic and Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: B Hemabarathy
authors.initials: BH
authors.lastname: Bharatham
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address: enoch@upm.edu.my.
authors.forename: Enoch Kumar
authors.initials: EK
authors.lastname: Perimal
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D003250:Constriction; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D009437:Neuralgia / Q000188:drug therapy*; D010147:Pain Measurement; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000627:therapeutic use*; D030521:Zingiberaceae / Q000737:chemistry
chemical_list: D000700:Analgesics; D012717:Sesquiterpenes; C403304:zerumbone
keywords: CCI; Neuropathic pain; Zerumbone; Zingiber zerumbet