title: Human papillomavirus (HPV) screening and cervical cancer burden. A Brazilian perspective.
abstract: This review tackles the issues related to disease burden caused by cervical cancer (CC) and its precursor (CIN) lesions in Brazil. A special focus is given to new technologies with potential to interfere with the development of CC by reducing the high-risk human papillomavirus (hr-HPV)-induced lesions that remain a major public health burden in all developing countries where organized screening programs do not exist. Globally, 85% of all incident CC and 50% of CC deaths occur in the developing countries. Unfortunately, most regions of Brazil still demonstrate high mortality rates, ranking CC as the second most common cancer among Brazilian women. Recently, CC screening programs have been tailored in the country to enable early detection of CC precursor lesions and thereby reduce cancer mortality. A combination of HPV testing with liquid-based cytology (LBC) seems to be a promising new approach in CC screening, with high expectation to offer an adequate control of CC burden in this country.
authors.affiliation: Molecular Oncology Center, Barretos Cancer Hospital, Barretos, Brazil. adriana.lorenzi@gmail.com.
authors.forename: Adriana T
authors.initials: AT
authors.lastname: Lorenzi
authors.affiliation: Molecular Oncology Center, Barretos Cancer Hospital, Barretos, Brazil. kari.syrjanen@biohit.fi.|Biohit HealthCare Oyj, Helsinki, Finland. kari.syrjanen@biohit.fi.
authors.forename: Kari J
authors.initials: KJ
authors.lastname: Syrjänen
authors.affiliation: Cancer Prevention Department, Barretos Cancer Hospital, Barretos, Brazil. longatto16@hotmail.com.|Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, São Paulo University, São Paulo, Brazil. longatto16@hotmail.com.|Life and Health Sciences Research Institute, ICVS, School of Health Sciences, Minho University, Braga, Portugal. longatto16@hotmail.com.|ICVS/3B's - PT Government Associate laboratory, Braga, Portugal. longatto16@hotmail.com.
authors.forename: Adhemar
authors.initials: A
authors.lastname: Longatto-Filho
mesh_terms: D001938:Brazil / Q000453:epidemiology; D003584:Cytological Techniques / Q000379:methods / Q000706:statistics & numerical data; D055088:Early Detection of Cancer / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods / Q000706:statistics & numerical data; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control