title: An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder.
abstract: This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.
authors.affiliation: Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Av. Sant Antoni Mª Claret 167, 08025 Barcelona Spain; Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Martín-Blanco
authors.affiliation: Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
authors.forename: Marc
authors.initials: M
authors.lastname: Ferrer
authors.affiliation: Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Av. Sant Antoni Mª Claret 167, 08025 Barcelona Spain; Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Soler
authors.affiliation: Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Av. Sant Antoni Mª Claret 167, 08025 Barcelona Spain; Fundació Docència i Recerca Mútua Terrassa, Terrassa, Spain.
authors.forename: Maria Jesús
authors.initials: MJ
authors.lastname: Arranz
authors.affiliation: Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain; Department of Psychiatry and Mental Health, Consorci Sanitari de l'Anoia, Spain; Institut of Neurosciences, Universitat Autònoma de Barcelona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Vega
authors.affiliation: Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Av. Sant Antoni Mª Claret 167, 08025 Barcelona Spain; Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain.
authors.forename: Joana
authors.initials: J
authors.lastname: Bauzà
authors.affiliation: Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Calvo
authors.affiliation: Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Av. Sant Antoni Mª Claret 167, 08025 Barcelona Spain; Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain.
authors.forename: Matilde
authors.initials: M
authors.lastname: Elices
authors.affiliation: Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sanchez-Mora
authors.affiliation: Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Iris
authors.initials: I
authors.lastname: García-Martinez
authors.affiliation: Department of Genetics, Hospital de la Santa Creu i Sant Pau, U705 CIBERER, Barcelona, Spain.
authors.forename: Juliana
authors.initials: J
authors.lastname: Salazar
authors.affiliation: Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Ribases
authors.affiliation: Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Av. Sant Antoni Mª Claret 167, 08025 Barcelona Spain; Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Carmona
authors.affiliation: Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Prat
authors.affiliation: Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Av. Sant Antoni Mª Claret 167, 08025 Barcelona Spain; Psychiatry and Legal Medicine Department, Universitat Autònoma de Barcelona, Spain. Electronic address: jpascual@santpau.cat.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Pascual
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000453:epidemiology* / Q000235:genetics* / Q000523:psychology; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002648:Child; D002649:Child Abuse / Q000523:psychology; D004299:Dopamine beta-Hydroxylase / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012189:Retrospective Studies
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D004299:Dopamine beta-Hydroxylase; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: Borderline Personality Disorder; Childhood trauma; Noradrenergic system