title: The Effect of Cyclooxygenase-2 Expression in Uterine Carcinosarcoma on Survival: A Reassessment Based on Mature Data.
abstract: OBJECTIVE
  To reassess the effect cyclooxygenase-2 (COX-2) expression in carcinosarcoma on survival based on mature 5-year survival data.
  
  
  METHODS
  A comparison of 5-year survival of 27 patients with carcinosarcoma according to the presence of COX-2 immunohistochemical staining and staining score was performed.
  
  
  RESULTS
  The 5-year survival of those with positive and negative COX-2 staining was statistically not different. However, there was a clear trend for more favorable 5-year survival in patients with a high staining score than in those with a low score, and the difference was of borderline significance (38.5% vs 7.1%; P = 0.06).
  
  
  CONCLUSIONS
  In view of the role of COX-2 in carcinogenesis, our finding that COX-2 expression may confer a better survival in patients with carcinosarcoma is intriguing. Larger studies are indicated to elucidate the effect of COX-2 expression on survival in patients with carcinosarcoma because this may have therapeutic implications.
authors.affiliation: *Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, and †Department of Pathology, E. Wolfson Medical Center, Holon, Israel; and ‡Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel.
authors.forename: Joseph
authors.initials: J
authors.lastname: Menczer
authors.forename: Letizia
authors.initials: L
authors.lastname: Schreiber
authors.forename: Esther
authors.initials: E
authors.lastname: Berger
authors.forename: Tally
authors.initials: T
authors.lastname: Levy
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000201:enzymology* / Q000401:mortality; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001859:Bone Neoplasms / Q000201:enzymology / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D002296:Carcinosarcoma / Q000201:enzymology* / Q000401:mortality; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D018284:Cystadenocarcinoma, Serous / Q000201:enzymology* / Q000401:mortality; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000201:enzymology* / Q000401:mortality
chemical_list: D014408:Biomarkers, Tumor; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human