title: ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects.
abstract: ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.
authors.affiliation: a Department of Gerontology , Federal University of São Carlos , São Carlos , SP , Brazil .
authors.forename: Patricia Regina
authors.initials: PR
authors.lastname: Manzine
authors.forename: Elena
authors.initials: E
authors.lastname: Marcello
authors.forename: Barbara
authors.initials: B
authors.lastname: Borroni
authors.forename: Willem
authors.initials: W
authors.lastname: Kamphuis
authors.forename: Elly
authors.initials: E
authors.lastname: Hol
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
authors.forename: Carla Crispim
authors.initials: CC
authors.lastname: Nascimento
authors.forename: Patricia
authors.initials: P
authors.lastname: de Godoy Bueno
authors.forename: Francisco
authors.initials: F
authors.lastname: Assis Carvalho Vale
authors.forename: Sofia Cristina
authors.initials: SC
authors.lastname: Iost Pavarini
authors.forename: Monica
authors.initials: M
authors.lastname: Di Luca
authors.forename: Márcia Regina
authors.initials: MR
authors.lastname: Cominetti
mesh_terms: D051722:ADAM Proteins / Q000097:blood / Q000235:genetics*; D000072197:ADAM10 Protein; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D053829:Amyloid Precursor Protein Secretases / Q000097:blood / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics*
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins; D012333:RNA, Messenger; D053829:Amyloid Precursor Protein Secretases; D051722:ADAM Proteins; D000072197:ADAM10 Protein; C491236:ADAM10 protein, human
keywords: Aging; biomarkers; blood; platelets