title: Polymorphisms of the ABCB1 Gene in the Pakistani Population.
abstract: OBJECTIVE
  To investigate the frequency of the single nucleotide polymorphism C1236T in exon 12 of the ABCB1 gene in Pakistani population and to compare it with published data on Asian and Caucasian populations.
  
  
  METHODS
  Across-sectional observational study.
  
  
  METHODS
  Combined Military Hospital, Rawalpindi and Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, from August 2012 to May 2013.
  
  
  METHODS
  C1236T polymorphism was investigated in 426 Pakistani subjects. The frequency was compared with the published data on other Asian and Caucasian populations.
  
  
  RESULTS
  The frequencies of ABCB1 C1236T were 16.4% for CC, 44.1% for CT and 39.4% for TT. Pakistanis differed significantly from all the European populations compared in the distribution of the TT genotype of C1236TABCB1 (p < 0.05). The Pakistani population also differed significantly from some of the European populations in the distribution of CC and CT genotype (p < 0.05).
  
  
  CONCLUSIONS
  There was significant difference in the genotype frequency of the ABCB1 gene compared to other populations. This study has provided a framework for future pharmacogenetic and pharmacokinetic studies on this polymorphic variant of ABCB1 gene in the Pakistani population.
authors.affiliation: Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi.
authors.forename: Kulsoom
authors.initials: K
authors.lastname: Farhat
authors.affiliation: Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi.
authors.forename: Akbar
authors.initials: A
authors.lastname: Waheed
authors.affiliation: Department of Pharmacy, Hamdard Institute of Pharmaceutical Sciences, Islamabad.
authors.forename: Azhar
authors.initials: A
authors.lastname: Hussain
authors.affiliation: Department of Pharmacy, Baluchistan University, Quetta.
authors.forename: Javeid
authors.initials: J
authors.lastname: Iqbal
authors.affiliation: Department of Genetics, Institute of Biomedicaland Genetic Engineering, Islamabad.
authors.forename: Qaisar
authors.initials: Q
authors.lastname: Mansoor
authors.affiliation: Department of Radiology, Shifa International Hospital, Islamabad.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ismail
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1