title: Ultrasound-Guided Intratendinous Injections With Platelet-Rich Plasma or Autologous Whole Blood for Treatment of Proximal Hamstring Tendinopathy: A Double-Blind Randomized Controlled Trial.
abstract: OBJECTIVE
  To compare the effects of ultrasound-guided platelet-rich plasma (PRP) and whole blood (WB) injections in patients with chronic hamstring tendinopathy.
  
  
  METHODS
  In a prospective double-blind randomized controlled trial, PRP or WB was injected under ultrasound guidance into the proximal hamstring tendon in a cohort of patients with clinically suspected hamstring tendinosis. Questionnaires were administered before injection and 2, 6, and 12 weeks and 6 months after injection. Pain and function outcomes were measured via the Modified Harris Hip Score (MHHS), Hip Outcome Scores for activities of daily living (ADL) and sport-specific function, and International Hip Outcome Tool 33 (IHOT-33). Diagnostic ultrasound was used to compare preinjection and 6-month postinjection tendon appearances.
  
  
  RESULTS
  The WB group showed greater improvements in pain and function over the PRP group before 12 weeks, whereas the PRP group showed improved outcomes over WB at 6 months. None of these between-group outcome measures, except 6-week IHOT-33, showed statistical significance. Comparing preinjection and 6-month scores, the PRP group showed significant improvements in ADL (P = .018) and IHOT-33 (P = .28) scores, whereas the WB group showed no significant improvements from baseline. The WB group showed significantly decreased pain with 15-minute sitting (P= .008) at 6 months. Ultrasound imaging showed no significant differences between PRP and WB group tendon appearances.
  
  
  CONCLUSIONS
  Both PRP and WB groups showed improvements in all outcome measures at 6 months. The PRP group showed significant improvements in 6-month ADL and IHOT-33 scores. The WB group reached significance in 15-minute sitting pain. No significant between-group differences were observed at any time point.
authors.affiliation: Preferred Orthopedics of the Palm Beaches, Boynton Beach, Florida USA (K.L.D.); Carteret Comprehensive Medical Care, PC, Carteret, New Jersey USA (J.S.C.); Departments of Epidemiology and Biostatistics (J.N.), Radiology and Imaging (G.S.), and Physiatry (P.J.M.), Hospital for Special Surgery, New York, New York USA; and Department of Radiology and Imaging, New York University Langone Medical Center, New York, New York USA (R.S.A.).
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Davenport
authors.affiliation: Preferred Orthopedics of the Palm Beaches, Boynton Beach, Florida USA (K.L.D.); Carteret Comprehensive Medical Care, PC, Carteret, New Jersey USA (J.S.C.); Departments of Epidemiology and Biostatistics (J.N.), Radiology and Imaging (G.S.), and Physiatry (P.J.M.), Hospital for Special Surgery, New York, New York USA; and Department of Radiology and Imaging, New York University Langone Medical Center, New York, New York USA (R.S.A.).
authors.forename: Jose Santiago
authors.initials: JS
authors.lastname: Campos
authors.affiliation: Preferred Orthopedics of the Palm Beaches, Boynton Beach, Florida USA (K.L.D.); Carteret Comprehensive Medical Care, PC, Carteret, New Jersey USA (J.S.C.); Departments of Epidemiology and Biostatistics (J.N.), Radiology and Imaging (G.S.), and Physiatry (P.J.M.), Hospital for Special Surgery, New York, New York USA; and Department of Radiology and Imaging, New York University Langone Medical Center, New York, New York USA (R.S.A.).
authors.forename: Joseph
authors.initials: J
authors.lastname: Nguyen
authors.affiliation: Preferred Orthopedics of the Palm Beaches, Boynton Beach, Florida USA (K.L.D.); Carteret Comprehensive Medical Care, PC, Carteret, New Jersey USA (J.S.C.); Departments of Epidemiology and Biostatistics (J.N.), Radiology and Imaging (G.S.), and Physiatry (P.J.M.), Hospital for Special Surgery, New York, New York USA; and Department of Radiology and Imaging, New York University Langone Medical Center, New York, New York USA (R.S.A.).
authors.forename: Gregory
authors.initials: G
authors.lastname: Saboeiro
authors.affiliation: Preferred Orthopedics of the Palm Beaches, Boynton Beach, Florida USA (K.L.D.); Carteret Comprehensive Medical Care, PC, Carteret, New Jersey USA (J.S.C.); Departments of Epidemiology and Biostatistics (J.N.), Radiology and Imaging (G.S.), and Physiatry (P.J.M.), Hospital for Special Surgery, New York, New York USA; and Department of Radiology and Imaging, New York University Langone Medical Center, New York, New York USA (R.S.A.).
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Adler
authors.affiliation: Preferred Orthopedics of the Palm Beaches, Boynton Beach, Florida USA (K.L.D.); Carteret Comprehensive Medical Care, PC, Carteret, New Jersey USA (J.S.C.); Departments of Epidemiology and Biostatistics (J.N.), Radiology and Imaging (G.S.), and Physiatry (P.J.M.), Hospital for Special Surgery, New York, New York USA; and Department of Radiology and Imaging, New York University Langone Medical Center, New York, New York USA (R.S.A.). moleyp@hss.edu.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Moley
mesh_terms: D001804:Blood Transfusion, Autologous / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007866:Leg; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000379:methods*; D053657:Platelet-Rich Plasma; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D052256:Tendinopathy / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*
keywords: hamstring; musculoskeletal ultrasound; platelet-rich plasma; ultrasound; whole blood