title: Flea (Ctenocephalides felis) control efficacy of topical indoxacarb on dogs subsequently bathed with a chlorhexidine-ketoconazole shampoo.
abstract: OBJECTIVE
  An evaluation of the effect of chlorhexidine/ketoconazole shampoo baths on the flea control efficacy of indoxacarb applied topically to dogs.
  
  
  RESULTS
  We randomly allocated 18 healthy mixed-breed dogs to 3 groups: shampoo only; indoxacarb treated and medicated shampoo; and indoxacarb treated but not shampooed. Indoxacarb was administered on day 0 and dogs were shampooed on days 9 and 23. Dogs were infested with 100 adult Ctenocephalides felis initially 2 days before treatment and then weekly from days 7 to 28. Fleas were removed and counted 48 h post-infestation.
  
  
  CONCLUSIONS
  Medicated shampoo use did not significantly reduce indoxacarb efficacy against C. felis.
authors.affiliation: MSD Animal Health, Madison, New Jersey, USA. robert.armstrong@merck.com.
authors.forename: R D
authors.initials: RD
authors.lastname: Armstrong
authors.affiliation: ClinVet International, Bloemfontein, Republic of South Africa.
authors.forename: J E
authors.initials: JE
authors.lastname: Liebenberg
authors.affiliation: MSD Animal Health, Madison, New Jersey, USA.
authors.forename: K
authors.initials: K
authors.lastname: Heaney
authors.affiliation: MSD Animal Health, Madison, New Jersey, USA.
authors.forename: F
authors.initials: F
authors.lastname: Guerino
mesh_terms: D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001494:Baths / Q000662:veterinary; D002710:Chlorhexidine / Q000008:administration & dosage; D058251:Ctenocephalides / Q000187:drug effects*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D004285:Dogs; D005260:Female; D058267:Flea Infestations / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D007306:Insecticides / Q000008:administration & dosage*; D007654:Ketoconazole / Q000008:administration & dosage; D008297:Male; D010078:Oxazines / Q000008:administration & dosage*
chemical_list: D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D007306:Insecticides; D010078:Oxazines; C401104:indoxacarb; D002710:Chlorhexidine; D007654:Ketoconazole
keywords: chlorhexidine; dogs; fleas; indoxacarb; ketoconazole; shampoo