title: Marine metagenomics as a source for bioprospecting.
abstract: This review summarizes usage of genome-editing technologies for metagenomic studies; these studies are used to retrieve and modify valuable microorganisms for production, particularly in marine metagenomics. Organisms may be cultivable or uncultivable. Metagenomics is providing especially valuable information for uncultivable samples. The novel genes, pathways and genomes can be deducted. Therefore, metagenomics, particularly genome engineering and system biology, allows for the enhancement of biological and chemical producers and the creation of novel bioresources. With natural resources rapidly depleting, genomics may be an effective way to efficiently produce quantities of known and novel foods, livestock feed, fuels, pharmaceuticals and fine or bulk chemicals.
authors.affiliation: Computational Bioscience Research Center (CBRC), Saudi Arabia; Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), Saudi Arabia; King Abdullah University of Science and Technology (KAUST), Saudi Arabia. Electronic address: Rimantas.Kodzius@kaust.edu.sa.
authors.forename: Rimantas
authors.initials: R
authors.lastname: Kodzius
authors.affiliation: Computational Bioscience Research Center (CBRC), Saudi Arabia; Biological and Environmental Sciences and Engineering Division (BESE), Saudi Arabia; King Abdullah University of Science and Technology (KAUST), Saudi Arabia. Electronic address: Takashi.Gojobori@kaust.edu.sa.
authors.forename: Takashi
authors.initials: T
authors.lastname: Gojobori
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D044822:Biodiversity; D005075:Biological Evolution; D055808:Drug Discovery; D005502:Food; D056186:Metagenomics
keywords: Bioprospecting; Genetic engineering; Metabolic engineering; Microorganism; Producer; Synthetic biology