title: Lanthanide Luminescence Modulation by Cation-π Interaction in a Bioinspired Scaffold: Selective Detection of Copper(I).
abstract: A prototype luminescent turn-on probe for Cu(+) (and Ag(+)) is described, harnessing a selective binding site (log Kass = 9.4 and 7.3 for Cu(+) and Ag(+), respectively) based on the coordinating environment of the bacterial metallo-chaperone CusF, integrated with a terbium-ion-signaling moiety. Cation-π interactions were shown to enhance tryptophan triplet population, which subsequently sensitized, on the microsecond timescale, the long-lived terbium emission, offering a novel approach in bioinspired chemosensor design.
authors.affiliation: Univ. Grenoble Alpes, LCBM/PMB, and CEA, IRTSV/CBM/PMB and CNRS, LCBM UMR 5249, PMB, 38000 Grenoble (France).
authors.forename: Manon
authors.initials: M
authors.lastname: Isaac
authors.affiliation: Univ. Bordeaux and CNRS, ISM (UMR 5255) and LOMA (UMR 5798), 33405 Talence (France).
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Denisov
authors.affiliation: Univ. Grenoble Alpes, LCBM/PMB, and CEA, IRTSV/CBM/PMB and CNRS, LCBM UMR 5249, PMB, 38000 Grenoble (France).
authors.forename: Amandine
authors.initials: A
authors.lastname: Roux
authors.affiliation: Univ. Grenoble Alpes and CEA, INAC/SCIB/RICC, 38000 Grenoble (France).
authors.forename: Daniel
authors.initials: D
authors.lastname: Imbert
authors.affiliation: Univ. Bordeaux and CNRS, ISM (UMR 5255) and LOMA (UMR 5798), 33405 Talence (France).
authors.forename: Gediminas
authors.initials: G
authors.lastname: Jonusauskas
authors.affiliation: Univ. Bordeaux and CNRS, ISM (UMR 5255) and LOMA (UMR 5798), 33405 Talence (France). nathan.mcclenaghan@u-bordeaux.fr.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: McClenaghan
authors.affiliation: Univ. Grenoble Alpes, LCBM/PMB, and CEA, IRTSV/CBM/PMB and CNRS, LCBM UMR 5249, PMB, 38000 Grenoble (France). olivier.seneque@cea.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Sénèque
mesh_terms: D002412:Cations; D002942:Circular Dichroism; D003300:Copper / Q000032:analysis*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D057230:Limit of Detection; D049449:Luminescence; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D002412:Cations; D028581:Lanthanoid Series Elements; D003300:Copper
keywords: cation-π interactions; copper; luminescence; peptides; terbium