title: An economic evaluation alongside a randomized controlled trial evaluating an individually tailored lifestyle intervention compared with usual care in people with familial hypercholesterolemia.
abstract: BACKGROUND
  Cost-effectiveness analyses provide insight in the use of lifestyle interventions. To evaluate the cost-effectiveness of a lifestyle intervention compared to usual care in people with Familial Hypercholesterolemia, 340 people with FH were randomized to the intervention or control group. LDL cholesterol, quality of life and costs were measured at 0 and 12 months. Cost-effectiveness analyses were performed from a healthcare perspective using bootstrapping techniques.
  
  
  RESULTS
  Non-significant decreases in LDL cholesterol and quality of life were found. The mean between-group difference in costs was €-237 (95% CI -1,386 to 130). The incremental cost-effectiveness ratios were 1,729 per 1 mmol/l LDL cholesterol and 145,899 per QALY gained. Assumed that the small non-significant decrease in LDL cholesterol is attributed to the intervention, the probability of cost-effectiveness of the intervention compared to usual care was 91% per 1 mmol/l LDL cholesterol reduction and 75% per QALY gained at a ceiling ratio of €20,000.
  
  
  CONCLUSIONS
  The intervention is not cost-effective.
  
  
  BACKGROUND
  NTR1899, date 07-07-2009.
authors.affiliation: Department of Public and Occupational Health, EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. info@karenbroekhuizen.nl.
authors.forename: Karen
authors.initials: K
authors.lastname: Broekhuizen
authors.affiliation: Department of Health Economics and Health Technology Assessment, Faculty of Earth and Life Sciences, Institute of Health Sciences, VU University, Amsterdam, The Netherlands. mvanwier@gmail.com.
authors.forename: Marieke F
authors.initials: MF
authors.lastname: van Wier
authors.affiliation: TNO, Division Work and Employment, Hoofddorp, The Netherlands. L.Koppes@nivel.nl.
authors.forename: Lando L J
authors.initials: LL
authors.lastname: Koppes
authors.affiliation: Department of Epidemiology and Biostatistics, EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. j.brug@vumc.nl.
authors.forename: Johannes
authors.initials: J
authors.lastname: Brug
authors.affiliation: Department of Public and Occupational Health, EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. w.vanmechelen@vumc.nl.
authors.forename: Willem
authors.initials: W
authors.lastname: van Mechelen
authors.affiliation: Department of Health Economics and Health Technology Assessment, Faculty of Earth and Life Sciences, Institute of Health Sciences, VU University, Amsterdam, The Netherlands. judith.bosmans@falw.vu.nl.
authors.forename: Judith E
authors.initials: JE
authors.lastname: Bosmans
authors.affiliation: Department of Public and Occupational Health, EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. mnm.vanpoppel@vumc.nl.
authors.forename: Mireille N M
authors.initials: MN
authors.lastname: van Poppel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood; D003362:Cost-Benefit Analysis; D037001:Directive Counseling / Q000191:economics*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000191:economics* / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D057285:Precision Medicine; D011788:Quality of Life / Q000523:psychology*; D019057:Quality-Adjusted Life Years; D057185:Sedentary Behavior
chemical_list: D008078:Cholesterol, LDL