title: Assessment of bilateral cerebral peduncular infarction: Magnetic resonance imaging, clinical features, and prognosis.
abstract: BACKGROUND
  Bilateral cerebral peduncular infarction (BCPI) is an extremely rare neurological disorder, and related literature is scarce. This study investigated the clinical manifestations, magnetic resonance imaging (MRI) features and prognosis of BCPI.
  
  
  METHODS
  We retrospectively reviewed the clinical features, MRI and magnetic resonance angiography manifestations, and prognosis of 14 patients with BCPI, confirmed by diffusion-weighted MRI from 5050 cerebral infarction patients at our medical center from January 2007 to June 2013.
  
  
  RESULTS
  Eleven of the 14 (78.6%) patients had quadriplegia and 9 (64.3%) had decreased consciousness. At the most severe stage, the National Institutes of Health Stroke Scale scores ranged from grades 4 to 26 (mean grade, 18.9). Eleven (78.6%) cases were caused by large artery atherosclerosis. Besides the bilateral cerebral peduncle, the pons (85.7%) and cerebellum (42.9%) were the other infarct locations. Twelve (85.7%) patients had vertebrobasilar artery occlusion or severe stenosis, and 12 (85.7%) did not have collateral patency of the posterior cerebral artery. Thirteen (92.9%) patients had poor prognosis and 9 of them died.
  BCPI is a very rare disorder and associated with severe vertebrobasilar artery stenosis or occlusion without collateral patency of the posterior communicating artery. It has a very poor prognosis.
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China. Electronic address: doctorwwenhuo@126.com.
authors.forename: WenHuo
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Tingyu
authors.initials: T
authors.lastname: Yi
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Yuehong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Meifang
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Zongzhong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Bailing
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Tinghui
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Chaoxin
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Miaoxiong
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
authors.forename: Yanchuan
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000453:epidemiology; D065850:Cerebral Peduncle / Q000473:pathology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
keywords: Bilateral cerebral peduncular; Infarction; Prognosis; Stenosis; Vertebrobasilar artery