title: Premature Aging in Fibromyalgia.
abstract: Chronic pain is highly prevalent in older adults, and until recently, was considered to be common but relatively "benign." Mounting evidence, however, suggests that some of the 116 million US adults who suffer from chronic pain are also at an increased risk for developing age-related diseases prematurely, suffering earlier cognitive and physical decline, and experiencing earlier mortality. Given the aging US population and the prevalence of chronic pain along with related healthcare consequences, there is a critical need to better understand the relationship between aging and chronic pain. Herein, we focus on one chronic pain state, fibromyalgia, and provide an overview of the evidence suggesting that individuals with this chronic pain condition show signs of premature aging.
authors.affiliation: Department of Anesthesiology, University of Michigan Medical School, Chronic Pain & Fatigue Research Center, Domino's Farms, Lobby M, P.O Box 385, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA. afton@med.umich.edu.
authors.forename: Afton L
authors.initials: AL
authors.lastname: Hassett
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Clauw
authors.forename: David A
authors.initials: DA
authors.lastname: Williams
mesh_terms: D000375:Aging; D016922:Cellular Senescence; D059350:Chronic Pain / Q000209:etiology; D005356:Fibromyalgia / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D013312:Stress, Physiological; D019098:Telomerase / Q000378:metabolism
chemical_list: D019098:Telomerase