title: Molecularly imprinted hydrogels as functional active packaging materials.
abstract: This paper describes the synthesis of novel molecularly imprinted hydrogels (MIHs) for the natural antioxidant ferulic acid (FA), and their application as packaging materials to prevent lipid oxidation of butter. A library of MIHs was synthesized using a synthetic surrogate of FA, 3-(4-hydroxy-3-methoxyphenyl)propionic acid (HFA), as template molecule, ethyleneglycol dimethacrylate (EDMA) as cross-linker, and 1-allylpiperazine (1-ALPP) or 2-(dimethylamino)ethyl methacrylate (DMAEMA), in combination with 2-hydroxyethyl methacrylate (HEMA) as functional monomers, at different molar concentrations. The DMAEMA/HEMA-based MIHs showed the greatest FA loading capacity, while the 1-ALLP/HEMA-based polymers exhibited the highest imprinting effect. During cold storage, FA-loaded MIHs protected butter from oxidation and led to TBARs values that were approximately half those of butter stored without protection and 25% less than those recorded for butter covered with hydrogels without FA, potentially extending the shelf life of butter. Active packaging is a new field of application for MIHs with great potential in the food industry.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, Avenida Complutense, s/n, Madrid 28040, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Benito-Peña
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, Avenida Complutense, s/n, Madrid 28040, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: González-Vallejo
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, Avenida Complutense, s/n, Madrid 28040, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Rico-Yuste
authors.affiliation: Department of Chemical Engineering, School of Industrial Engineering, University of Vigo, Campus As Lagoas, Marcosende, 36310 Vigo, Spain.
authors.forename: Letricia
authors.initials: L
authors.lastname: Barbosa-Pereira
authors.affiliation: Department of Chemical Engineering, School of Industrial Engineering, University of Vigo, Campus As Lagoas, Marcosende, 36310 Vigo, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Cruz
authors.affiliation: Biotechnology Division, GAIKER-IK4 Technology Centre, Ed. 202, 48170 Zamudio, Spain.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Bilbao
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address: carmen.alvarez.lorenzo@usc.es.
authors.forename: Carmen
authors.initials: C
authors.lastname: Alvarez-Lorenzo
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, Avenida Complutense, s/n, Madrid 28040, Spain. Electronic address: mcmbondi@quim.ucm.es.
authors.forename: María Cruz
authors.initials: MC
authors.lastname: Moreno-Bondi
mesh_terms: D003373:Coumaric Acids / Q000737:chemistry; D018857:Food Packaging; D020100:Hydrogels / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000138:chemical synthesis
chemical_list: D003373:Coumaric Acids; D020100:Hydrogels; D008689:Methacrylates; D011108:Polymers; C005044:hydroxyethyl methacrylate; C004919:ethylene dimethacrylate; C004999:ferulic acid; C049840:2-(dimethylamino)ethyl methacrylate
keywords: Antioxidant capacity; Binding isotherms; Ferulic acid; Food packaging; Molecular imprinting