title: Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections.
abstract: It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.|Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University, Jerusalem, Israel.
authors.forename: Yonatan M
authors.initials: YM
authors.lastname: Kupchik
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.|Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
authors.forename: Robyn M
authors.initials: RM
authors.lastname: Brown
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Jasper A
authors.initials: JA
authors.lastname: Heinsbroek
authors.affiliation: Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Lobo
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Danielle J
authors.initials: DJ
authors.lastname: Schwartz
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Kalivas
mesh_terms: D000818:Animals; D066187:Basal Forebrain / Q000737:chemistry / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009434:Neural Pathways / Q000737:chemistry / Q000378:metabolism; D009714:Nucleus Accumbens / Q000737:chemistry / Q000378:metabolism*; D062308:Optogenetics / Q000379:methods; D017447:Receptors, Dopamine D1 / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2