title: [Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy].
abstract: We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.
authors.affiliation: Institute of Biochemistry of Biologically Active Compounds NASB.
authors.forename: I V
authors.initials: IV
authors.lastname: Zverinsky
authors.affiliation: Institute of Biochemistry of Biologically Active Compounds NASB.
authors.forename: H G
authors.initials: HG
authors.lastname: Zverinskaya
authors.affiliation: Institute of Biochemistry of Biologically Active Compounds NASB.
authors.forename: I P
authors.initials: IP
authors.lastname: Sutsko
authors.affiliation: Institute of Biochemistry of Biologically Active Compounds NASB.
authors.forename: P G
authors.initials: PG
authors.lastname: Telegin
authors.affiliation: Institute of Biochemistry of Biologically Active Compounds NASB.
authors.forename: A G
authors.initials: AG
authors.lastname: Shlyahtun
mesh_terms: D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006498:Hepatectomy; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000601:surgery; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism; D017208:Rats, Wistar; D015262:Xenobiotics / Q000493:pharmacokinetics
chemical_list: D015262:Xenobiotics; D001599:Berberine; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming)
keywords: berberine; cytochrome P450; flavin-containing monooxygenases; partial hepatectomy