title: Arterial stiffness and endothelial inflammation in prediabetes and newly diagnosed diabetes patients.
abstract: OBJECTIVE
  There is a growing body of data supporting the association between diabetes and microcirculatory disfunction. We aimed to study e-selectin levels, and their associations with serum markers of inflammation and arterial stiffness in prediabetes and newly diagnosed diabetes patients in this study.
  
  
  METHODS
  Sixty patients (25 females) with a newly established elevated fasting serum glucose [20 impaired fasting glucose (IFG), 20 impaired glucose tolerance (IGT), 20 newly diagnosed diabetes (T2DM)] and 17 healthy controls (13 females) were included in the study. Serum e-selectin and hs-CRP levels, and arterial stiffness parameters of the patients were studied.
  
  
  RESULTS
  Fasting serum glucose was the most important predictor of serum e-selectin levels. Pulse wave velocity and central aortic pressures were significantly higher in IFG, IGT and T2DM groups, compared to controls (p = 0.001, < 0.001, 0.013 and 0.015, 0.002, 0.009, respectively). The mean arterial pressure did not show any significant association with serum e-selectin and hs-CRP levels (β coefficient: 0.092, p = 0.358; and β coefficient: 0.189, p = 0.362, respectively).
  
  
  CONCLUSIONS
  Prediabetes patients have increasing e-selectin levels through the diagnosis of T2DM. E-selectin is associated with serum glucose levels. Prediabetic and newly diagnosed diabetics have higher arterial stiffness measurements. Serum e-selectin may be a good marker of endothelial inflammation and dysfunction increasing in parallel with serum glucose levels, predicting future cardiovascular events.
authors.affiliation: Internal Medicine, Eskişehir Military Hospital, Eskişehir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çakar
authors.affiliation: Cardiology, Eskişehir Military Hospital, Eskişehir, Turkey.
authors.forename: Şevket
authors.initials: Ş
authors.lastname: Balta
authors.affiliation: Internal Medicine, Diyarbakır Military Hospital, Diyarbakır, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Şarlak
authors.affiliation: Department of Internal Medicine, Gulhane Medical Academy, Etlik-Ankara, Turkey.
authors.forename: Muharrem
authors.initials: M
authors.lastname: Akhan
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Etlik-Ankara, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.affiliation: Department of Nephrology, Gulhane Medical Academy, Etlik-Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Karaman
authors.affiliation: Department of Endocrinology, Haydarpaşa Training Hospital, Gulhane Medical Faculty, İstanbul, Turkey.
authors.forename: Seyit Ahmet
authors.initials: SA
authors.lastname: Ay
authors.affiliation: Department of Gastroenterology, Gulhane Medical Academy, Etlik-Ankara, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Kurt
authors.affiliation: Department of Biochemistry, Gulhane Medical Academy, Etlik-Ankara, Turkey.
authors.forename: Tuncer
authors.initials: T
authors.lastname: Çayci
authors.affiliation: Internal Medicine, Eskişehir Military Hospital, Eskişehir, Turkey.
authors.forename: Satılmış
authors.initials: S
authors.lastname: İnal
authors.affiliation: Department of Internal Medicine, Gulhane Medical Academy, Etlik-Ankara, Turkey.
authors.forename: Şeref
authors.initials: Ş
authors.lastname: Demirbaş
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology; D019040:E-Selectin / Q000097:blood*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology; D005215:Fasting / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011236:Prediabetic State / Q000378:metabolism* / Q000503:physiopathology; D063177:Pulse Wave Analysis; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D019040:E-Selectin; D002097:C-Reactive Protein