title: Experimental animal model to study iron overload and iron chelation and review of other such models.
abstract: The disorders of iron overload due to primary or secondary cause are one of the important human diseases leading to high mortality if untreated. To understand this, an animal model has been extensively studied. The source of iron administered to the mode of iron administration that can mimic the iron overload in humans has been studied. A safe and orally active iron chelator is still needed as many of the existing compounds have different types of complications and toxicity associated. Hence having a simple animal model which can be availed quickly and can be used to study various compounds for its iron chelating activity would likely to have immense utility for pharmacological studies. In this review we have shown how, using a simple procedure, a large number of small iron overloaded animals can be produced easily for various studies.
authors.affiliation: Hematogenetics Department, National Institute of Immunohaematology, India. Electronic address: kyitalia4@gmail.com.
authors.forename: Khushnooma
authors.initials: K
authors.lastname: Italia
authors.affiliation: Hematogenetics Department, National Institute of Immunohaematology, India. Electronic address: colahrb@gmail.com.
authors.forename: Roshan
authors.initials: R
authors.lastname: Colah
authors.affiliation: National Institute of Immunohaematology, India. Electronic address: kanjakshaghosh@hotmail.com.
authors.forename: Kanjaksha
authors.initials: K
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D015913:Chelation Therapy; D004195:Disease Models, Animal; D006801:Humans; D019190:Iron Overload / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
keywords: Animal model; Balb/c mice; Gerbil; Iron overload; Iron-dextran; Iron-sucrose