title: N(6) -Methyladenine: A Potential Epigenetic Mark in Eukaryotic Genomes.
abstract: N(6) -methyladenine (6mA) is known to be an epigenetic mark in bacterial genomes. Three studies have now demonstrated the existence of significant levels of 6mA in the genomes of several phylogenetically distinct eukaryotes, along with findings that suggest that 6mA may act as a dynamic epigenetic mark in the regulation of eukaryotic gene expression.
authors.affiliation: Department of Chemistry and Konstanz Research School, Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz (Germany). daniel.summerer@uni-konstanz.de.
authors.forename: Daniel
authors.initials: D
authors.lastname: Summerer
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005057:Eukaryotic Cells; D016678:Genome
chemical_list: D000225:Adenine; C000730567:6-methyladenine
keywords: DNA methylation; N6-methyladenine; epigenetics; transcriptional regulation