title: Peripheral arterial disease in patients with giant cell arteritis: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association between giant cell arteritis (GCA) and risk of peripheral arterial disease (PAD).
  
  
  METHODS
  We conducted a systematic review and meta-analysis of observational cohort studies that reported relative risks, hazard ratios or standardized incidence ratios with 95% confidence comparing PAD risk in patients with GCA versus non-GCA subjects. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird.
  
  
  RESULTS
  Four studies with 9789 patients with GCA and 236 728 controls were identified and included in our data analysis. The pooled risk ratio of PAD among patients with GCA compared with controls was 1.88 (95% CI 1.04-3.41). The statistical heterogeneity was high with an I(2) of 89%.
  
  
  CONCLUSIONS
  Our study demonstrated a statistically significant increased risk of PAD among patients with GCA.
authors.affiliation: Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.|Department of medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Charat
authors.initials: C
authors.lastname: Thongprayoon
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Wonngarm
authors.initials: W
authors.lastname: Kittanamongkolchai
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Narat
authors.initials: N
authors.lastname: Srivali
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Wisit
authors.initials: W
authors.lastname: Cheungpasitporn
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D013700:Giant Cell Arteritis / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D064887:Observational Studies as Topic; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors
keywords: epidemiology; vasculitides (clinical aspects); vasculitides (general epidemiology studies)