title: Early post-operative ventricular arrhythmias in patients with continuous-flow left ventricular assist devices.
abstract: BACKGROUND
  Ventricular arrhythmias (VAs) are common in patients with a continuous-flow left ventricular assist device (CF-LVAD). The causes and clinical significance of early post-operative VAs have not previously been characterized in these patients. The purpose of this study was to assess the incidence, precipitants, and clinical impact of early VAs in patients supported by CF-LVADs.
  
  
  METHODS
  Patients with a long-term CF-LVAD receiving care between January 1, 2012, and March 1, 2014, were enrolled and followed prospectively. Implantable cardioverter-defibrillators (ICDs) were interrogated at baseline and throughout the follow-up period. VA was defined as ventricular tachycardia or ventricular fibrillation lasting >30 seconds or effectively terminated by appropriate ICD tachytherapy or external defibrillation. The primary end-point was the occurrence of early VAs (within 30 days of surgery). Secondary end-points were right ventricular (RV) failure and need for VA ablation.
  
  
  RESULTS
  There were 162 patients enrolled, and 38 (23.5%) experienced at least 1 early VA. Predictors of early VA were a history of pre-operative VAs, non-ischemic cardiomyopathy, and older age. Several conditions frequently encountered in the early post-operative period were identified as possible precipitants for VA episodes. Early VAs were associated with post-operative RV failure, particularly when patients received shocks instead of anti-tachycardia pacing.
  
  
  CONCLUSIONS
  Early VAs are common and are associated with RV failure. ICD shocks, but not anti-tachycardia pacing, for early VAs are associated with acute worsening of RV failure.
authors.affiliation: Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York. Electronic address: arg2024@cumc.columbia.edu.
authors.forename: Arthur R
authors.initials: AR
authors.lastname: Garan
authors.affiliation: Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York.
authors.forename: Allison P
authors.initials: AP
authors.lastname: Levin
authors.affiliation: Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York.
authors.forename: Veli
authors.initials: V
authors.lastname: Topkara
authors.affiliation: Department of Medicine, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Sunu S
authors.initials: SS
authors.lastname: Thomas
authors.affiliation: Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York.
authors.forename: Melana
authors.initials: M
authors.lastname: Yuzefpolskaya
authors.affiliation: Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York.
authors.forename: Paolo C
authors.initials: PC
authors.lastname: Colombo
authors.affiliation: Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Medical Center, New York, New York.
authors.forename: Koji
authors.initials: K
authors.lastname: Takeda
authors.affiliation: Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Medical Center, New York, New York.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Takayama
authors.affiliation: Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Medical Center, New York, New York.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Naka
authors.affiliation: Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York.
authors.forename: William
authors.initials: W
authors.lastname: Whang
authors.affiliation: Department of Medicine, Division of Cardiology, Montefiore Medical Center, New York, New York.
authors.forename: Ulrich P
authors.initials: UP
authors.lastname: Jorde
authors.affiliation: Department of Medicine, Division of Cardiology, University of Chicago Medical Center, Chicago, Illinois.
authors.forename: Nir
authors.initials: N
authors.lastname: Uriel
mesh_terms: D005260:Female; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011474:Prosthesis Design; D017180:Tachycardia, Ventricular / Q000209:etiology*; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000209:etiology*
keywords: ICD; LVAD; ablation; right ventricular failure; suction event; ventricular arrhythmia; ventricular tachycardia