title: Additional Effects of Platelet-Rich Fibrin on Bone Regeneration in Sinus Augmentation With Deproteinized Bovine Bone Mineral: Preliminary Results.
abstract: OBJECTIVE
  Platelet-rich fibrin (PRF) has been reported to contribute to bone regeneration; however, little is known about details with deproteinized bovine bone mineral (DBBM). This study aims to evaluate additional effects of PRF on bone regeneration in sinus augmentation with DBBM.
  
  
  METHODS
  Sinus augmentations were made with DBBM/PRF mixture as lateral approach for 4 sinuses from 4 patients. Bone biopsies were obtained from posterior maxilla at the implant placements 7 or 10 months after sinus augmentations. Histological observations and histomorphometric analyses from augmented areas were performed.
  
  
  RESULTS
  The new bone formation was found around the DBBMs with very good contact while surfaces of DBBMs were partly resorbed. Osteoclasts recognized the DBBMs for remodeling, followed by new bone running. The histomorphometric analyses revealed that mean percentages of newly formed bone were 31.7 ± 1.2%, 21.0 ± 1.0%, 38.0 ± 0.6%, and 47.0 ± 0.6%, respectively (mean 34.5 ± 5.7%).
  
  
  CONCLUSIONS
  Additional effects of PRF could be found because of higher percentages of newly bone formation by DBBM/PRF mixture than those by DBBM individual in previous reports.
authors.affiliation: *Resident, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University; Regenerative Dentistry and Implant Center, Kyushu University Hospital. †Assistant Professor, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University. ‡Assistant Professor, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University. §Lecturer, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University. ¶Assistant Professor, Regenerative Dentistry and Implant Center, Kyushu University Hospital. ‖Associate Professor, Regenerative Dentistry and Implant Center, Kyushu University Hospital; Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University. #Resident, Regenerative Dentistry and Implant Center, Kyushu University Hospital. **Professor, Regenerative Dentistry and Implant Center, Kyushu University Hospital; Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University. ††Professor, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Toyoshima
authors.forename: Ikiru
authors.initials: I
authors.lastname: Atsuta
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ayukawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Sasaki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Matsushita
authors.forename: Ryu
authors.initials: R
authors.lastname: Hiraoka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Koyano
authors.forename: Seiji
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000539:Alveolar Process / Q000033:anatomy & histology / Q000187:drug effects; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000627:therapeutic use; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods; D005337:Fibrin / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D059546:Sinus Floor Augmentation / Q000379:methods*
chemical_list: D018786:Bone Substitutes; D005337:Fibrin