title: Randomized Controlled Trial on the Effect of Channa striatus Extract on Measurement of the Uterus, Pulsatility Index, Resistive Index of Uterine Artery and Superficial Skin Wound Artery in Post Lower Segment Caesarean Section Women.
abstract: OBJECTIVE
  To compare the mean of anteroposterior (AP) measurements of the uterus in longitudinal and oblique transverse planes, and the pulsatility index (PI) and resistive index (RI) of the uterine artery and superficial skin wound artery between patients taking Channa striatus and placebo.
  
  
  BACKGROUND
  Channa striatus, also known as haruan, is a fresh water snakehead fish consumed in many parts of Southeast Asia. Channa striatus is also normally consumed by women postpartum to promote wound healing as well as to reduce post-operative pain.
  
  
  METHODS
  This study is a randomised, double blind, placebo-controlled study conducted in women after Lower Segment Caesarean Section (LSCS). Subjects were randomised to either a Channa striatus or a placebo group and were given a daily dosage of 500 mg of Channa striatus extract or 500 mg maltodextrin, respectively, for six weeks post LSCS. The anteroposterior measurements of the uterus in the longitudinal and oblique transverse planes, and the pulsatility index (PI) and resistive index (RI) of the uterine and superficial skin wound arteries were assessed using pelvic Gray-scale ultrasound and Doppler ultrasound at baseline (Day 3) and at two weeks, four weeks and six weeks post-operatively.
  
  
  RESULTS
  Sixty-six subjects were randomised into the study with 33 in the Channa striatus group and 33 in the placebo group. No significant differences were detected in terms of the pulsatility index (PI) and the resistive index (RI) of the uterine and superficial skin wound arteries between the Channa striatus and placebo groups. However, in the Channa striatus group, the AP measurements of the uterus on the longitudinal and oblique transverse planes were significantly lower compared to the placebo group (p<0.05 and p<0.001, respectively).
  
  
  CONCLUSIONS
  Daily intake of Channa striatus extract results in marked differences compared to placebo in terms of uterine involution and recovery in women post LSCS.
  
  
  BACKGROUND
  www.isrctn.com 11960786.
authors.affiliation: Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Mohd Rizal
authors.initials: MR
authors.lastname: Abu Bakar
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Azidah
authors.initials: A
authors.lastname: Abdul Kadir
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Siti Zubaidah
authors.initials: SZ
authors.lastname: Abdul Wahab
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Ahmad Helmy
authors.initials: AH
authors.lastname: Abdul Karim
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Nik Hazlina
authors.initials: NH
authors.lastname: Nik Hussain
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Norhayati
authors.initials: N
authors.lastname: Mohd Noor
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Julia
authors.initials: J
authors.lastname: Omar
authors.affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Saringat
authors.initials: S
authors.lastname: Bin Bai Bae
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Wan Haslindawani
authors.initials: WH
authors.lastname: Wan Mahmood
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Asrenee
authors.initials: A
authors.lastname: Abdul Razak
authors.affiliation: International Medical University, Seremban, Malaysia.
authors.forename: Rohaizan
authors.initials: R
authors.lastname: Yunus
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D004311:Double-Blind Method; D005260:Female; D005399:Fishes / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D012871:Skin Diseases / Q000473:pathology / Q000517:prevention & control*; D014020:Tissue Extracts / Q000494:pharmacology*; D016896:Treatment Outcome; D055988:Uterine Artery / Q000187:drug effects* / Q000473:pathology; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000473:pathology / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D014020:Tissue Extracts