title: Immediate tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline.
abstract: OBJECTIVE
  The aim of this study was to evaluate the influence of systemic administration of antibiotics (amoxicillin and tetracycline) at the different phases of the repair process (7, 15, 30 days) in immediate rat tooth replantation.
  
  
  METHODS
  Ninety rats had their incisors extracted and stored in saline for 5 min. Next, the teeth were replanted, and the animals were assigned to three groups according to the antibiotic administered by oral gavage: control group, amoxycillin group, and tetracycline group. Euthanasia was performed at 7, 15, and 30 days after replantation.
  
  
  RESULTS
  Regardless of the evaluation period, the connective tissue underlying the epithelial attachment and the periodontal ligament showed statistically significant difference relative to the acute inflammatory infiltrate, which was more intense in the control group followed by the tetracycline group.
  
  
  CONCLUSIONS
  These results point to the fact that systemic antibiotic therapy (SAT) in immediate tooth replantation is beneficial to pulpal and periodontal ligament repair and that amoxycillin is an excellent option.
  
  
  CONCLUSIONS
  There is a lack of randomized studies assessing how the use of systemic antibiotics could influence tooth healing after immediate replantation.
authors.affiliation: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Moriel Evangelista
authors.initials: ME
authors.lastname: Melo
authors.affiliation: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Cristina Antoniali
authors.initials: CA
authors.lastname: Silva
authors.affiliation: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Weglis Dyanne
authors.initials: WD
authors.lastname: de Souza Gomes
authors.affiliation: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Vanessa Ferreira
authors.initials: VF
authors.lastname: da Silva
authors.affiliation: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Daniela Atili
authors.initials: DA
authors.lastname: Brandini
authors.affiliation: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Wilson Roberto
authors.initials: WR
authors.lastname: Poi
authors.affiliation: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Lithiene Ribeiro
authors.initials: LR
authors.lastname: Castilho
authors.affiliation: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Celso Koogi
authors.initials: CK
authors.lastname: Sonoda
authors.affiliation: Department of Surgery and Integrated Clinic, Discipline of Integrated Clinic, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Rua José Bonifácio 1193, CEP, 1601-050, Araçatuba, São Paulo, Brazil. panzarin@foa.unesp.br.
authors.forename: Sônia Regina
authors.identifier: http://orcid.org/0000-0002-0397-4914
authors.initials: SR
authors.lastname: Panzarini
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004846:Epithelial Attachment / Q000187:drug effects*; D007180:Incisor / Q000601:surgery*; D008297:Male; D010513:Periodontal Ligament / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D014090:Tooth Replantation / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000658:Amoxicillin; D013752:Tetracycline
keywords: Amoxycillin; Immediate tooth replantation; Root resorption; Tetracycline