title: Histone lysine demethylases in Drosophila melanogaster.
abstract: Epigenetic regulation of chromatin structure is a fundamental process for eukaryotes. Regulators include DNA methylation, microRNAs and chromatin modifications. Within the chromatin modifiers, one class of enzymes that can functionally bind and modify chromatin, through the removal of methyl marks, is the histone lysine demethylases. Here, we summarize the current findings of the 13 known histone lysine demethylases in Drosophila melanogaster, and discuss the critical role of these histone-modifying enzymes in the maintenance of genomic functions. Additionally, as histone demethylase dysregulation has been identified in cancer, we discuss the advantages for using Drosophila as a model system to study tumorigenesis.
authors.affiliation: a Department of Oncology ; Wayne State University School of Medicine ; Detroit , MI USA.
authors.forename: Andreana
authors.initials: A
authors.lastname: Holowatyj
authors.forename: Zeng-Quan
authors.initials: ZQ
authors.lastname: Yang
authors.forename: Lori A
authors.initials: LA
authors.lastname: Pile
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000201:enzymology*; D056466:Histone Demethylases / Q000378:metabolism*; D056484:Jumonji Domain-Containing Histone Demethylases / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology
chemical_list: D056466:Histone Demethylases; D056484:Jumonji Domain-Containing Histone Demethylases
keywords: Drosophila; Epigenetics; JmjC domain; KDM; cancer; chromatin; demethylase; histone; modifications; tumorigenesis