title: Outpatient parenteral antimicrobial therapy (OPAT) in patients with cystic fibrosis.
abstract: BACKGROUND
  To determine complications during outpatient parenteral antimicrobial therapy (OPAT) administrated through a peripheral venous line, PICC-line or PORT-A-CATH (PAC).
  
  
  METHODS
  Catheter related complications in patients with cystic fibrosis during OPAT were identified through a retrospective review of patient files supplemented by an interview.
  
  
  RESULTS
  In 64 treatment episodes with a peripheral venous line, 51 (79.7 %) used bolus injection and 13 (20.3 %) used infusion pump. 27 out of 51 (53.0 %) bolus injection episodes experienced complications, which required removal. None were observed for infusion pump treatments. The infectious complications requiring removal of peripheral venous line were 9 out of 23 (39.1 %) for the PICC line and 11 out of 26 (42.3 %) for the PAC. No anaphylaxis was observed during the OPAT treatments.
  
  
  CONCLUSIONS
  Our data indicate that using an infusion pump to administer the antibiotic treatment minimized peripheral venous line complications. The frequency of complications leading to removal of the catheter is about the same for PICC-lines and PACs, but the average life-time of the latter is much longer. Allergic reactions are not a major problem.
authors.affiliation: Department of Infectious Diseases, Aarhus University Hospital Skejby, Palle Juul jensens Boulevard 100, Aarhus, Denmark. mayagrahampedersen@gmail.com.
authors.forename: Maya Graham
authors.initials: MG
authors.lastname: Pedersen
authors.affiliation: Department of Infectious Diseases, Aarhus University Hospital Skejby, Palle Juul jensens Boulevard 100, Aarhus, Denmark. soejense@rm.dk.
authors.forename: Søren
authors.initials: S
authors.lastname: Jensen-Fangel
authors.affiliation: Department of Pediatrics, Aarhus University Hospital Skejby, Palle Juul jensens Boulevard 100, Aarhus, Denmark. hannoles@rm.dk.
authors.forename: Hanne Vebert
authors.initials: HV
authors.lastname: Olesen
authors.affiliation: Department of Anestesiology, Aarhus University Hospital Skejby, Palle Juul jensens Boulevard 100, Aarhus, Denmark. sandtamb@rm.dk.
authors.forename: San Deep Prataprao
authors.initials: SD
authors.lastname: Tambe
authors.affiliation: Department of Infectious Diseases, Aarhus University Hospital Skejby, Palle Juul jensens Boulevard 100, Aarhus, Denmark. joepeter@rm.dk.
authors.forename: Eskild
authors.initials: E
authors.lastname: Petersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis; D003718:Denmark; D005260:Female; D018718:Home Infusion Therapy / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects; D008297:Male; D017063:Outcome Assessment, Health Care; D010045:Outpatients; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents