title: Iodine(III)-Mediated Oxy-fluorination of Alkenyl Oximes: An Easy Path to Monofluoromethyl-Substituted Isoxazolines.
abstract: A highly regioselective intramolecular oxy-fluorination of alkenyl oximes was achieved. This new transformation represents an efficient method for the preparation of monofluoromethyl-substituted isoxazolines. The synthetic application of the oxy-fluorination product was demonstrated by a one-step synthesis of monofluoromethyl-substituted β-hydroxyl ketone derivatives.
authors.affiliation: †School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.|‡Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Kong
authors.affiliation: ‡Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Quanping
authors.initials: Q
authors.lastname: Guo
authors.affiliation: ‡Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Xu
authors.affiliation: ‡Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Wang
authors.affiliation: †School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Xianxing
authors.initials: X
authors.lastname: Jiang
authors.affiliation: †School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.|‡Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang