title: Sodium-activated macrophages: the salt mine expands.
abstract: High sodium consumption has been raising interest as a putative environmental factor linking Western lifestyle to the growing epidemic of autoimmune and inflammatory diseases. Now Zhang and colleagues show that high sodium drives macrophage to acquire a new proinflammatory effector phenotype with a distinct signature, paving the path to assess the role of salt-activated macrophages in human disease.
authors.affiliation: Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.
authors.forename: Liliana E
authors.initials: LE
authors.lastname: Lucca
authors.affiliation: Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Hafler
mesh_terms: D000818:Animals; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects*; D012965:Sodium Chloride / Q000009:adverse effects*
chemical_list: D012965:Sodium Chloride