title: HIV-1 Genetic Diversity and Transmitted Drug Resistance Among Recently Infected Individuals at Men Who Have Sex with Men Sentinel Surveillance Points in Hebei Province, China.
abstract: For this study, 50 HIV-1 plasma samples of recently infected men who have sex with men (MSM) were amplified and sequenced. Multiple subtypes were identified by phylogenetic analyses of HIV-1 gag, env, and pol gene regions, including CRF01_AE (56.0%), CRF07_BC (30.0%), subtype B (12.0%), and unique recombinant forms (URFs, 6.0%). CRF01_AE was the most frequent genotype in the epidemic. Three recombination patterns of URFs were identified: 01BC, 01B, and 01C. The rate of HIV-1 transmitted drug resistance (TDR) mutation (M46L) was 2.08% (1/48). URFs and TDR first identified in this study suggest that HIV-1 prevalence is more and more complicated, and HIV-1 drug-resistant strains have begun to spread among at risk populations in Hebei. Our findings can provide vital information for an efficient surveillance system and strategic HIV prevention and control measures in China by revealing the evolutionary status and HIV-1 TDR of HIV-1 strains among recently infected MSM in Hebei Province.
authors.affiliation: 1 College of Biology Science, Hebei University , Baoding, People's Republic of China .|2 Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China .
authors.forename: Xinli
authors.initials: X
authors.lastname: Lu
authors.affiliation: 1 College of Biology Science, Hebei University , Baoding, People's Republic of China .
authors.forename: Xianjiang
authors.initials: X
authors.lastname: Kang
authors.affiliation: 2 Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China .
authors.forename: Suliang
authors.initials: S
authors.lastname: Chen
authors.affiliation: 2 Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China .
authors.forename: Hongru
authors.initials: H
authors.lastname: Zhao
authors.affiliation: 3 Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, People's Republic of China .
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 2 Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China .
authors.forename: Cuiying
authors.initials: C
authors.lastname: Zhao
authors.affiliation: 2 Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China .
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 3 Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, People's Republic of China .
authors.forename: Jingyun
authors.initials: J
authors.lastname: Li
authors.affiliation: 2 Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China .
authors.forename: Ze
authors.initials: Z
authors.lastname: Cui
authors.affiliation: 4 Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China .
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D024882:Drug Resistance, Viral; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D018571:Sentinel Surveillance; D017422:Sequence Analysis, DNA; D055815:Young Adult; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D054299:env Gene Products, Human Immunodeficiency Virus; D054301:gag Gene Products, Human Immunodeficiency Virus; D054302:pol Gene Products, Human Immunodeficiency Virus