title: In Situ Biosynthesis of Fluorescent Platinum Nanoclusters: Toward Self-Bioimaging-Guided Cancer Theranostics.
abstract: Among the noble-metal clusters, very few reports about platinum clusters were used as bioimaging probes of tumors except as a reducing catalyst. It is first established herein that the biocompatible platinum nanoclusters are spontaneously biosynthesized by cancerous cells (i.e., HepG2 (human hepatocarcinoma), A549 (lung cancer), and others) rather than noncancerous cells (i.e., L02 (human embryo liver cells)) when incubated with micromolar chloroplatinic acid solutions. These in situ biosynthesized platinum nanoclusters could be readily realized in a biological environment and emit a bright fluorescence at 460 nm, which could be further utilized to facilitate an excellent cancer-cell-killing efficiency when combined with porphyrin derivatives for photothermal treatment. This raises the possibility of providing a promising and precise bioimaging strategy for specific fluorescent self-biomarking of tumor locations and realizing fluorescence imaging-guided photothermal therapy of tumors.
authors.affiliation: †State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.|‡School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
authors.forename: Donghua
authors.initials: D
authors.lastname: Chen
authors.affiliation: †State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Zhao
authors.affiliation: †State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.affiliation: †State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Li
authors.affiliation: †State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.affiliation: †State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Meina
authors.initials: M
authors.lastname: Su
authors.affiliation: †State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: §CNRS UMR 8640 PASTEUR and LIA NanoBioCatEchem, Ecole Normale Supérieure-PSL Research University, Département de Chimie, Sorbonne Universités-UPMC Paris 6, 24 rue Lhomond, 75005 Paris, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Amatore
authors.affiliation: ∥Department of Chemistry and Biochemistry, California State University, Los Angeles, California 90032, United States.
authors.forename: Matthias
authors.initials: M
authors.lastname: Selke
authors.affiliation: †State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D002460:Cell Line; D005456:Fluorescent Dyes / Q000737:chemistry*; D045325:HCT116 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000473:pathology / Q000628:therapy; D010789:Phototherapy; D010984:Platinum / Q000737:chemistry*; D017671:Platinum Compounds / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism; D000068936:Theranostic Nanomedicine; D014183:Transplantation, Heterologous
chemical_list: D005456:Fluorescent Dyes; D017671:Platinum Compounds; D011166:Porphyrins; D017382:Reactive Oxygen Species; C002999:chloroplatinic acid; D010984:Platinum
keywords: bioimaging; cancer; photothermal treatment; platinum nanoclusters; theranostics