title: Dissecting the Genetic Architecture of Behavior inDrosophila melanogaster.
abstract: Variation in behaviors in natural populations arises from complex networks of multiple segregating polymorphic alleles whose expression can be modulated by the environment. Since behaviors reflect dynamic interactions between organisms and their environments, they are central targets for adaptive evolution.Drosophila melanogasterpresents a powerful system for dissecting the genetic basis of behavioral phenotypes, since both the genetic background and environmental conditions can be controlled and behaviors accurately quantified. Single gene mutational analyses can identify the roles of individual genes within cellular pathways, whereas systems genetic approaches that exploit natural variation can construct genetic networks that underlie phenotypic variation. Combining these approaches with emerging technologies, such as genome editing, is likely to yield a comprehensive understanding of the neurogenetic underpinnings that orchestrate the manifestation of behaviors.
authors.affiliation: Department of Biological Sciences, W. M. Keck Center for Behavioral Biology, and Program in Genetics, North Carolina State University, Box 7614, Raleigh, NC 27695-7614, USA.
authors.forename: Robert R H
authors.initials: RR
authors.lastname: Anholt
authors.affiliation: Department of Biological Sciences, W. M. Keck Center for Behavioral Biology, and Program in Genetics, North Carolina State University, Box 7614, Raleigh, NC 27695-7614, USA.
authors.forename: Trudy F C
authors.initials: TF
authors.lastname: Mackay