title: Physical exercise for late-life major depression.
abstract: BACKGROUND
  Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available.
  
  
  OBJECTIVE
  To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression.
  
  
  METHODS
  Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lower-intensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of ≤10 on the Hamilton Rating Scale for Depression).
  
  
  RESULTS
  A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group.
  
  
  CONCLUSIONS
  Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression.
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group martino.belvederi@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Belvederi Murri
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: M
authors.initials: M
authors.lastname: Amore
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: M
authors.initials: M
authors.lastname: Menchetti
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: G
authors.initials: G
authors.lastname: Toni
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: F
authors.initials: F
authors.lastname: Neviani
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: M
authors.initials: M
authors.lastname: Cerri
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: M B L
authors.initials: MB
authors.lastname: Rocchi
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: D
authors.initials: D
authors.lastname: Zocchi
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: L
authors.initials: L
authors.lastname: Bagnoli
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: E
authors.initials: E
authors.lastname: Tam
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: A
authors.initials: A
authors.lastname: Buffa
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: S
authors.initials: S
authors.lastname: Ferrara
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: M
authors.initials: M
authors.lastname: Neri
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: G S
authors.initials: GS
authors.lastname: Alexopoulos
authors.affiliation: Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
authors.forename: S
authors.initials: S
authors.lastname: Zanetidou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000628:therapy*; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence; D012074:Remission Induction; D020280:Sertraline / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D020280:Sertraline