title: DRESS syndrome: cerebral vasculitic-like presentation.
abstract: BACKGROUND
  DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a severe adverse drug-induced reaction. It manifests with pyrexia, eosinophilia, and lymphadenopathy, with multiple organ involvement, mainly the skin, liver, and kidneys. The purpose of this article is to demonstrate that DRESS syndrome can be associated with cerebral manifestations, a concept not well known in the neuroradiological literature.
  
  
  METHODS
  We describe three cases of DRESS syndrome associated with cerebral vasculitic-like lesions and realize a review of the literature to demonstrate that this association represents a very rare entity.
  
  
  RESULTS
  Acute ischemic lesions were found among two patients. In all cases, perivascular enhancement was present. Magnetic resonance angiography (MRA) sequence was normal. Although no cerebral biopsy was performed, this enhancement pattern is strongly suggestive of a vasculitic process associated with DRESS syndrome.
  
  
  CONCLUSIONS
  Diagnosis of cerebral vasculitic-like associated lesions must be considered in patients with DRESS syndrome since it can be reversed completely by withdrawing the causal medication and instigating corticosteroid treatment in a timely fashion.
authors.affiliation: Department of Neuroradiology, Montreal University Hospital (CHUM), Montreal, Canada. mehdi.gaha@yahoo.fr.|Department of Radiology, Sahloul University Hospital, Sousse, Tunisia. mehdi.gaha@yahoo.fr.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Gaha
authors.affiliation: Department of Neuroradiology, Montreal University Hospital (CHUM), Montreal, Canada.|Notre-Dame Hospital CHUM, 1560 Sherbrooke East Street, Montreal, Quebec, H2L 4M1, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Landry
authors.affiliation: Department of Neuroradiology, Montreal University Hospital (CHUM), Montreal, Canada.|Notre-Dame Hospital CHUM, 1560 Sherbrooke East Street, Montreal, Quebec, H2L 4M1, Canada.
authors.forename: Manon
authors.initials: M
authors.lastname: Bélair
authors.affiliation: Department of Immunology, Montreal University Hospital (CHUM), Montreal, Canada.|Notre-Dame Hospital CHUM, 1560 Sherbrooke East Street, Montreal, Quebec, H2L 4M1, Canada.
authors.forename: Brenda
authors.initials: B
authors.lastname: Paquet
authors.affiliation: Department of Immunology, Montreal University Hospital (CHUM), Montreal, Canada.|Notre-Dame Hospital CHUM, 1560 Sherbrooke East Street, Montreal, Quebec, H2L 4M1, Canada.
authors.forename: Hugo
authors.initials: H
authors.lastname: Chapdelaine
authors.affiliation: Department of Neuroradiology, Montreal University Hospital (CHUM), Montreal, Canada.|Notre-Dame Hospital CHUM, 1560 Sherbrooke East Street, Montreal, Quebec, H2L 4M1, Canada.
authors.forename: Céline
authors.initials: C
authors.lastname: Bard
mesh_terms: D002536:Cerebral Arteries / Q000473:pathology*; D003937:Diagnosis, Differential; D063926:Drug Hypersensitivity Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008875:Middle Aged; D020293:Vasculitis, Central Nervous System / Q000473:pathology*
keywords: Brain; Drug-induced hypersensitivity; Vasculitis