title: Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex.
abstract: The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors. We used optogenetic approaches in behaving mice to either activate or inhibit BLA inputs to the mPFC during behavioral assays that assess anxiety-like behavior and social interaction. Channelrhodopsin-2 (ChR2)-mediated activation of BLA inputs to the mPFC produced anxiogenic effects in the elevated plus maze and open field test, whereas halorhodopsin (NpHR)-mediated inhibition produced anxiolytic effects. Furthermore, activation of the BLA-mPFC pathway reduced social interaction in the resident-intruder test, whereas inhibition facilitated social interaction. These results establish a causal relationship between activity in the BLA-mPFC pathway and the bidirectional modulation of anxiety-related and social behaviors.
authors.affiliation: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: acfo@mit.edu.
authors.forename: A C
authors.initials: AC
authors.lastname: Felix-Ortiz
authors.affiliation: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: aburgos@mit.edu.
authors.forename: A
authors.initials: A
authors.lastname: Burgos-Robles
authors.affiliation: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Program in Behavioral Neuroscience, Northeastern University, Boston, MA 02115, USA. Electronic address: bhagat.n@husky.neu.edu.
authors.forename: N D
authors.initials: ND
authors.lastname: Bhagat
authors.affiliation: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: cleppla@mit.edu.
authors.forename: C A
authors.initials: CA
authors.lastname: Leppla
authors.affiliation: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: kaytye@mit.edu.
authors.forename: K M
authors.initials: KM
authors.lastname: Tye
mesh_terms: D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D001007:Anxiety / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D018782:Maze Learning; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D017397:Prefrontal Cortex / Q000503:physiopathology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D012919:Social Behavior
chemical_list: D016760:Proto-Oncogene Proteins c-fos
keywords: anxiety disorders; fear; infralimbic; optogenetics; prelimbic; stress