title: Liver involvement of Langerhans' cell histiocytosis in children.
abstract: OBJECTIVE
  Liver involvement is relatively frequent in children with Langerhans cell histiocytosis (LCH). Its features remain poorly defined.
  
  
  METHODS
  A retrospective study was carried out on 14 hepatic LCH children in our hospital. The Clinicopathological and radiological features of this disease was discussed.
  
  
  RESULTS
  The rate of liver involvement in children LCH patients is 51.9%. Majority of the patients were disseminated cases. Hepatomegaly was clinically confirmed in 11 cases (78.6%). Liver function dysfunction was seen in nine (64.3%) children. The association of multi-modal imaging significantly yielded more diagnostic information. There are some imaging characteristics of this disease, CT and MRI could help to assess the staging, extent of the hepatic lesions. We found that liver involvement had a significant impact on survival. Patients treated with systemic chemotherapy earlier from time of diagnosis had a relatively better outcome.
  
  
  CONCLUSIONS
  The rate of liver involvement in children LCH patients maybe much higher than that of expected. We suggest that clinical and biological liver evaluation and abdominal imaging must be performed regularly onwards to screen every LCH children patient from the time of the initial diagnosis. Patient should be treated with systemic chemotherapy earlier.
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yi
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zai
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Xueying
authors.initials: X
authors.lastname: Long
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Wenzheng
authors.initials: W
authors.lastname: Li
keywords: Langerhans cell histiocytosis (LCH); children; imaging; liver involvement; prognosis