title: Vaccines for fungal infections.
abstract: High morbidity and mortality caused by mycotic infections has been a cause for concern. Trials for various vaccines against fungal pathogens have not been approved by the US Food and Drugs Administration because of the high cost of production and lack of a single suitable candidate. Most fungal infections require cell-mediated immunity for their clearance. This has been the basis for the development of various vaccines. We discuss the various trials of candidate vaccines, the protective efficacy as well as their shortcomings. Recent research suggests that a universal vaccine can be prepared which may be effective against most fungal pathogens.
authors.affiliation: Department of Microbology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095.
authors.forename: Urvashi
authors.initials: U
authors.lastname: Tiwari
authors.affiliation: Department of Microbology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, shukladas_123@yahoo.com.
authors.forename: Shukla
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Microbology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095.
authors.forename: Mukta
authors.initials: M
authors.lastname: Tandon
authors.affiliation: Department of Microbology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095.
authors.forename: V G
authors.initials: VG
authors.lastname: Ramachandran
authors.affiliation: Department of Microbology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095.
authors.forename: Rumpa
authors.initials: R
authors.lastname: Saha
mesh_terms: D056704:Adaptive Immunity; D001230:Aspergillus / Q000276:immunology; D001758:Blastomyces / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D003455:Cryptococcus neoformans / Q000276:immunology; D005657:Fungal Vaccines; D006801:Humans; D007113:Immunity, Innate; D009181:Mycoses / Q000517:prevention & control*; D045363:Pneumocystis carinii / Q000276:immunology
chemical_list: D005657:Fungal Vaccines