title: A comprehensive classification of solvent systems used for natural product purifications in countercurrent and centrifugal partition chromatography.
abstract: Using both library paper copies and modern electronic copies, every known, published, English-language journal paper that employs either countercurrent or centrifugal partition chromatography solvent systems for natural product purifications has been studied and the solvent systems classified in a comprehensive database. Papers were studied from the earliest found examples containing natural product separations in 1984 until the end of 2014. In total, 2594 solvent systems have been classified, of which 272 are gradient systems. To observe any trends or patterns in the data, the natural product solutes were divided into 21 classes and the solvent systems into 7 different types. The complete database, sorted according to natural product class, is available for download to assist separation scientists in future liquid-liquid chromatography purifications.
authors.affiliation: Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 1 Chodzki Str, 20-093 Lublin, Poland. kskalicka@pharmacognosy.org.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Skalicka-Woźniak
authors.affiliation: Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK. ian.garrard@brunel.ac.uk.
authors.forename: Ian
authors.initials: I
authors.lastname: Garrard
mesh_terms: D001688:Biological Products; D002853:Chromatography, Liquid; D003377:Countercurrent Distribution; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry*
chemical_list: D001688:Biological Products; D012997:Solvents