title: Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation.
abstract: Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro model based on the differentiation of mouse embryonic stem cells (mESCs), and published the major findings in a research article entitled "Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells" [1]. The data presented herein contains complementary information related to the aforementioned research article.
authors.affiliation: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA.
authors.forename: Xiugong
authors.initials: X
authors.lastname: Gao
authors.affiliation: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Sprando
authors.affiliation: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Yourick
keywords: Developmental toxicity; Differentiation; Embryonic stem cell; Microarray; Mouse; Thalidomide; Transcriptomics