title: Strategies for early detection of cardiotoxicities from anticancer therapy in adults: evolving imaging techniques and emerging serum biomarkers.
abstract: Significant advances have been made in detecting cancer therapeutics-related cardiac dysfunction with serum biomarkers, cardiovascular MRI, echocardiography and multi-modality approaches. Serum biomarkers, notably cardiac troponins and natriuretic peptides, have been evaluated for their prognostic ability in predicting left ventricular dysfunction. Imaging modalities, such as cardiovascular MRI and echocardiography, have been used for cardiac surveillance of patients with cancer undergoing chemotherapy. Developments in imaging, specifically myocardial deformation imaging, also known as strain, have been shown to be sensitive tools in detecting early changes in cardiac function. This review aims to synthesize the evidence that supports emerging serum biomarkers and complementary imaging modalities that continue to enhance the detection of cancer therapeutics-related cardiac dysfunction.
authors.affiliation: Division of Cardiology, Northwestern University, Feinberg School of Medicine, 676 N St Clair, Suite 600, Chicago, IL 60611, USA.
authors.forename: Nausheen
authors.initials: N
authors.lastname: Akhter
authors.affiliation: Division of Radiology, Northwestern University, Feinberg School of Medicine, 676 N St Clair, Suite 600, Chicago, IL 60611, USA.
authors.forename: Gillian
authors.initials: G
authors.lastname: Murtagh
authors.affiliation: Division of Cardiology, Northwestern University, Feinberg School of Medicine, 676 N St Clair, Suite 600, Chicago, IL 60611, USA.
authors.forename: Clyde
authors.initials: C
authors.lastname: Yancy
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood*; D057791:Cardiac Imaging Techniques / Q000379:methods*; D066126:Cardiotoxicity / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D004452:Echocardiography / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*; D009195:Peroxidase / Q000097:blood; D019210:Troponin I / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D019210:Troponin I; D009195:Peroxidase
keywords: CMR; CTRCD; MPO; biomarkers; cancer therapeutics-related cardiac dysfunction; cardiovascular MRI; echocardiography; highly sensitive Troponin I; hsTnI; myeloperoxidase; myocardial deformation imaging; strain imaging