title: The retromer complex in development and disease.
abstract: The retromer complex is a multimeric protein complex involved in recycling proteins from endosomes to the trans-Golgi network or plasma membrane. It thus regulates the abundance and subcellular distribution of its cargo within cells. Studies using model organisms show that the retromer complex is involved in specific developmental processes. Moreover, a number of recent studies implicate aberrant retromer function in photoreceptor degeneration, Alzheimer's disease and Parkinson's disease. Here, and in the accompanying poster, we provide an overview of the molecular and cellular mechanisms of retromer-mediated protein trafficking, highlighting key examples of retromer function in vivo.
authors.affiliation: Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Shiuan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA hbellen@bcm.edu.
authors.forename: Hugo J
authors.initials: HJ
authors.lastname: Bellen
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D046912:Multiprotein Complexes / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction; D033921:Vesicular Transport Proteins / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism; D021601:trans-Golgi Network / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D046912:Multiprotein Complexes; C498296:VPS26A protein, human; C419572:VPS29 protein, human; C419573:VPS35 protein, human; D033921:Vesicular Transport Proteins; D051153:Wnt Proteins
keywords: Alzheimer's disease; Endocytic recycling; Epithelial apical polarity; Heme formation; Parkinson's disease; Photoreceptor degeneration; Retromer; Wingless/Wnt signaling