title: Mutations of short tandem repeat loci in cases of paternity testing in Chinese.
abstract: In order to find out the characteristics of genetic mutations in 15 short tandem repeat (STR) loci, 3734 parentage cases were analyzed using AmpFlSTR Sinofiler kit. The allele source, mutation rate, and mutation rule of the STR loci were determined. Seventy mutations were observed in all cases for paternity testing. Among 15 STR loci, the highest mutation rate was observed in D12S391 (0.21 %), but the D5S818 gene mutation rate was relatively low (0.02 %). One-step mutation cases accounted for 95.7 % of all of the cases monitored. And the mutations in this study mainly showed paternal mutation (64/70). The research results are of great significance for identification and paternity tests and for the improvement of genetic studies on Chinese population in the future.
authors.affiliation: Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China.|Center for DNA Typing, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Sun
authors.affiliation: Center for DNA Typing, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: XiaoNan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Center for DNA Typing, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China.|Center for DNA Typing, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China. wuym@fmmu.edu.cn.|Center for DNA Typing, Fourth Military Medical University, Xi'an, 710032, China. wuym@fmmu.edu.cn.
authors.forename: YuanMing
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China. fsm1973@sina.com.
authors.forename: ShanMin
authors.initials: S
authors.lastname: Fu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009154:Mutation; D059645:Mutation Rate; D010334:Paternity; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
keywords: Gene locus; Genetic polymorphism; Short tandem repeat (STR)