title: Association analysis of genetic variants of adiponectin gene and risk of pancreatic cancer.
abstract: Adiponectin is a cytokine exclusively secreted from adipocyte, and could perform direct or indirect effects on anti-inflammation and anti-tumor. Previous researches have studied the correlation between plasma adiponectin levels and the risk of pancreatic cancer. So we aimed at investigating the association of genetic variants of adiponectin gene and the risk of pancreatic cancer. In this study, we genotyped 6 SNPs of adiponectin gene in a case-control study of recruited 172 patients of pancreatic cancer and 181 healthy people in Chinese Han population. The results indicated that two of the SNPs had significant associations with pancreatic cancer. Of which, the SNP rs1501299C>A decreased the risk of PC (P=0.016, OR=0.662 95% CI 0.472-0.928), while rs1065358T>C increased the risk of PC (P=0.027, OR=1.421 95% CI 1.040-1.941). Furthermore, in the clinical correlation analysis, we found rs1501299 was correlated with tumor size (P=0.026), cigarette smoking (P=0.022) and alcohol consumption (P=0.001) and rs1063538 was correlated with alcohol consumption (P=0.026). In conclusion, we provided evidences that the variants in adiponectin gene might influence the development and progression of pancreatic cancer.
authors.affiliation: Department of Pathology, The First Affliated Hospital of Zhengzhou University 1# Jian She Dong Lu, Zhengzhou 450052, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Yang
authors.affiliation: Department of Oncology, The First Affliated Hospital of Zhengzhou University 1# Jian She Dong Lu, Zhengzhou 450052, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Oncology, The First Affliated Hospital of Zhengzhou University 1# Jian She Dong Lu, Zhengzhou 450052, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Oncology, The First Affliated Hospital of Zhengzhou University 1# Jian She Dong Lu, Zhengzhou 450052, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Pathology, The First Affliated Hospital of Zhengzhou University 1# Jian She Dong Lu, Zhengzhou 450052, China.
authors.forename: Sheng-Lei
authors.initials: SL
authors.lastname: Li
authors.affiliation: Department of Pathology, The First Affliated Hospital of Zhengzhou University 1# Jian She Dong Lu, Zhengzhou 450052, China.
authors.forename: Kui-Sheng
authors.initials: KS
authors.lastname: Chen
keywords: Adiponectin gene; pancreatic cancer; single nucleotide polymorphism