title: Cellular and Molecular Connections between Autophagy and Inflammation.
abstract: Autophagy is an intracellular catabolic pathway essential for the recycling of proteins and larger substrates such as aggregates, apoptotic corpses, or long-lived and superfluous organelles whose accumulation could be toxic for cells. Because of its unique feature to engulf part of cytoplasm in double-membrane cup-shaped structures, which further fuses with lysosomes, autophagy is also involved in the elimination of host cell invaders and takes an active part of the innate and adaptive immune response. Its pivotal role in maintenance of the inflammatory balance makes dysfunctions of the autophagy process having important pathological consequences. Indeed, defects in autophagy are associated with a wide range of human diseases including metabolic disorders (diabetes and obesity), inflammatory bowel disease (IBD), and cancer. In this review, we will focus on interrelations that exist between inflammation and autophagy. We will discuss in particular how mediators of inflammation can regulate autophagy activity and, conversely, how autophagy shapes the inflammatory response. Impact of genetic polymorphisms in autophagy-related gene on inflammatory bowel disease will be also discussed.
authors.affiliation: Université Bourgogne Franche-Comté, UMR PAM, Équipe Vin, Aliment, Microbiologie, Stress, 21000 Dijon, France ; Agrosup Dijon, UMR PAM, Équipe Vin, Aliment, Microbiologie, Stress, 21000 Dijon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lapaquette
authors.affiliation: Université Bourgogne Franche-Comté, UMR PAM, Équipe Vin, Aliment, Microbiologie, Stress, 21000 Dijon, France ; Agrosup Dijon, UMR PAM, Équipe Vin, Aliment, Microbiologie, Stress, 21000 Dijon, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Guzzo
authors.affiliation: INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, 21000 Dijon, France ; CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, 21000 Dijon, France ; Université Bourgogne Franche-Comté, Centre des Sciences du Goût et de l'Alimentation, 21000 Dijon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Bretillon
authors.affiliation: INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, 21000 Dijon, France ; CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, 21000 Dijon, France ; Université Bourgogne Franche-Comté, Centre des Sciences du Goût et de l'Alimentation, 21000 Dijon, France.
authors.forename: Marie-Agnès
authors.initials: MA
authors.lastname: Bringer
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics