title: Challenges and new strategies for therapeutic peptide delivery to the CNS.
abstract: Therapeutic peptides represent a largely untapped resource in medicine today, especially in the central nervous system. Despite their ease of design and remarkably high target specificity, it is difficult to deliver them beyond the blood-brain barrier or into the required intracellular compartments. In addition, the instability of these peptides in vivo precludes their use to combat the symptoms of numerous neurological disorders including Alzheimer's disease and spinocerebellar ataxia. In this review, we aim to characterize recent advances in the delivery of therapeutic peptides to the central nervous system past the blood-brain barrier and discuss the advantages and disadvantages of the examined methods as well as explore new potential directions.
authors.affiliation: Program in Neuroscience, School of Graduate Studies, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS39216, USA.|Department of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
authors.forename: Jeremy Wd
authors.initials: JW
authors.lastname: McGowan
authors.affiliation: Department of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
authors.forename: Gene L
authors.initials: GL
authors.lastname: Bidwell
authors.affiliation: Department of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
authors.forename: Parminder Js
authors.initials: PJ
authors.lastname: Vig
mesh_terms: D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000378:metabolism*; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000378:metabolism*; D002491:Central Nervous System Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D004333:Drug Administration Routes; D004337:Drug Carriers; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D010539:Permeability; D055550:Protein Stability; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D057846:Cell-Penetrating Peptides; D002491:Central Nervous System Agents; D004337:Drug Carriers; D005079:Excipients; D010455:Peptides