title: Renal 123I-MIBG Scintigraphy Before and After Kidney Autotransplantation.
abstract: A 25-year-old man underwent an autotransplantation of his right kidney because of fibromuscular dysplasia-induced renal artery stenosis and subsequent hypertension. Since transplantation results in complete kidney denervation, it enabled assessment of renal sympathetic nerve activity changes using renal I-MIBG scintigraphy. Before and 2 weeks after transplantation I-MIBG, scintigraphy was performed. Uptake of I-MIBG in the left (control) kidney increased after transplantation with 4% at 15 minutes and 5% at 4 hours postinjection images, whereas I-MIBG uptake in the right transplanted kidney decreased with 21% at 15 minutes and with 29% at 4 hours, demonstrating renal I-MIBG changes after denervation.
authors.affiliation: From the Departments of *Internal Medicine-Nephrology and Kidney Transplant Unit; †Internal Medicine-Vascular Medicine, ‡Vascular and Transplant Surgery; and §Nuclear Medicine, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Linn C
authors.initials: LC
authors.lastname: Dobrowolski
authors.forename: Daan W
authors.initials: DW
authors.lastname: Eeftinck Schattenkerk
authors.forename: Mirza M
authors.initials: MM
authors.lastname: Idu
authors.forename: Bert-Jan H
authors.initials: BJ
authors.lastname: van den Born
authors.forename: Hein J
authors.initials: HJ
authors.lastname: Verberne
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation; D008297:Male; D055420:Perfusion Imaging; D019275:Radiopharmaceuticals; D014182:Transplantation, Autologous
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine