title: Serum Gamma-glutamyl Transferase Concentration Within the Reference Range is Related to the Coronary Heart Disease Risk Prediction in Korean Men: Analysis of the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011).
abstract: BACKGROUND
  Limited data exist on the association of serum gamma-glutamyl transferase (GGT) level within the reference range with the increased risk of coronary heart disease (CHD) prediction in men. The study examined the association between serum GGT concentration within the reference range and the CHD risk prediction in Korean men.
  
  
  METHODS
  The study employed data from Korean National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011) where a total of 1301 individuals were analyzed. A 10-year CHD risk prediction was computed using the Framingham Risk Score (FRS) modified by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III).
  
  
  RESULTS
  Positive correlations were established between log-transformed GGT concentration and FRS (r = 0.237, P < 0.001). After adjustment of body mass index, the amount of alcohol intake and low-density lipoprotein-cholesterol, the odds ratio (95% confidence interval) for intermediate risk and beyond of 10-year CHD prediction (10-year risk ≥10%) with lowest quartile of participants was 1.21 (0.78-1.87) for second quartiles, 1.39 (0.88-2.21) for third quartiles and 2.03 (1.23-3.34) for highest quartiles.
  
  
  CONCLUSIONS
  Higher serum GGT within its reference range was significantly correlated with a 10-year CHD risk prediction estimation using NCEP ATP III in Korean men.
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Han
authors.forename: Doo-Yeoun
authors.initials: DY
authors.lastname: Cho
authors.forename: Young-Sang
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Family Practice and Community Health, Ajou University School of Medicine, 164 Worldcup-Ro, Youngtong-Gu, Suwon, Gyeonggi-Do, Republic of Korea.
authors.forename: Kyu-Nam
authors.initials: KN
authors.lastname: Kim
mesh_terms: D000328:Adult; D044466:Asian People; D003327:Coronary Disease / Q000175:diagnosis* / Q000201:enzymology*; D006801:Humans; D008297:Male; D009749:Nutrition Surveys; D012016:Reference Values; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism*
chemical_list: D005723:gamma-Glutamyltransferase