title: Relationship between inflammatory cytokines and risk of depression, and effect of depression on the prognosis of high grade glioma patients.
abstract: Depression is found to be associated with up-regulation of inflammatory cytokines. However, the relationship in high grade glioma (HGG) patients is still unclear. In this prospective study, a total 132 HGG patients participated in blood sample collection for inflammatory cytokines detection by ELISA, mental status, quality of life (QOL) and physical functional status testing. The association between inflammatory cytokines and depression risk was assessed using conditional logistic regression. The incidences of depressive symptoms and depression in high grade glioama patients were 45.5 and 25 % respectively during 12 months follow-up. We found the risk of depression was elevated with increased C-reactive protein (CRP) and interleukin-6 (IL-6) in high grade glioma patients after adjustment of confounders. The serum levels of CRP and IL-6 in patients with transient depression and depression were higher than those without depressive symptoms. In addition, depression had significant effects on the survival, QOL and physical functional status of patients. Depression is prevalent among patients with HGG. The present study suggests that serum CRP and IL-6 may serve as a depression marker for HGG patients. The survival and quality of life of HGG patients may be improved by an effective management for depression.
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China. tongjianjiao@126.com.
authors.forename: Jian-tong
authors.initials: JT
authors.lastname: Jiao
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
authors.forename: Jian-fen
authors.initials: JF
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
authors.forename: Min-chao
authors.initials: MC
authors.lastname: Dai
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China. wxhneurosurgery@126.com.
authors.forename: Jun-fei
authors.initials: JF
authors.lastname: Shao
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005910:Glioma / Q000097:blood* / Q000150:complications*; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life
chemical_list: D016207:Cytokines; D002097:C-Reactive Protein
keywords: Depression; High grade glioma; Inflammatory cytokines; Quality of life; Survival