title: Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment.
abstract: OBJECTIVE
  To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  French community-dwelling people.
  
  
  METHODS
  Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self-reported PA and amyloid-β brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n = 268).
  
  
  METHODS
  A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR-).
  
  
  RESULTS
  Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR- participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E ε4 carriers or noncarriers. PA was not associated with cognitive function.
  
  
  CONCLUSIONS
  Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid-β brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimer's disease.
authors.affiliation: Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Centre Hospitalier Universitaire Toulouse, Toulouse, France.|UMR INSERM 1027, University of Toulouse III, Toulouse, France.
authors.forename: Philipe
authors.initials: P
authors.lastname: de Souto Barreto
authors.affiliation: Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Centre Hospitalier Universitaire Toulouse, Toulouse, France.|UMR INSERM 1027, University of Toulouse III, Toulouse, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Andrieu
authors.affiliation: UMR 825, University of Toulouse III, Toulouse, France.|Department of Nuclear Medicine, University Hospital of Toulouse (CHU-Toulouse), Toulouse, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Payoux
authors.affiliation: Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Centre Hospitalier Universitaire Toulouse, Toulouse, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Demougeot
authors.affiliation: Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Centre Hospitalier Universitaire Toulouse, Toulouse, France.|UMR INSERM 1027, University of Toulouse III, Toulouse, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Rolland
authors.affiliation: Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Centre Hospitalier Universitaire Toulouse, Toulouse, France.|UMR INSERM 1027, University of Toulouse III, Toulouse, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism / Q000517:prevention & control; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D049268:Positron-Emission Tomography
chemical_list: D016229:Amyloid beta-Peptides
keywords: Alzheimer's disease; amyloid plaques; elderly; older adults; physical activity