title: [Coronary atherosclerosis and progression to unstable plaques : Histomorphological and molecular aspects].
abstract: Atherosclerosis causes clinical symptoms through luminal narrowing by stenosis or by precipitating thrombi that obstruct blood flow to the myocardium (coronary artery disease), central nervous system (ischemic stroke) or lower extremities (peripheral vascular disease). The most common of these manifestations of atherosclerosis is coronary artery disease, clinically presenting as either stable angina or acute coronary syndromes. Atherosclerosis is a mainly lipoprotein-driven disease, which is associated with the formation of atherosclerotic plaques at specific sites of the vascular system through inflammation, necrosis, fibrosis and calcification. In most cases, plaque rupture of a so-called thin-cap fibroatheroma leads to contact of the necrotic core material of the underlying atherosclerotic plaque with blood, resulting in the formation of a thrombus with acute occlusion of the affected (coronary) artery. The atherosclerotic lesions that can cause acute coronary syndromes by formation of a thrombotic occlusion encompass (1) thin-cap fibroatheroma, (2) plaque erosion and (3) so-called calcified nodules in calcified and tortuous arteries of aged individuals. The underlying pathomechanisms remain incompletely understood so far. In this review, the mechanisms of atherosclerotic plaque initiation and progression are discussed.
authors.affiliation: Institut für Pathologie, Universitätsklinik Essen, Essen, Deutschland. wohlschlaegerje@diako.de.|Institut für Pathologie, Evang.-luth. Diakonissenanstalt zu Flensburg, Flensburg, Deutschland. wohlschlaegerje@diako.de.
authors.forename: Jeremias
authors.initials: J
authors.lastname: Wohlschlaeger
authors.affiliation: Institut für Pathologie, Universitätsklinik Essen, Essen, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Bertram
authors.affiliation: Institut für Pathologie, Universitätsklinik Essen, Essen, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Theegarten
authors.affiliation: Institut für Pathologie, Universitätsklinik Essen, Essen, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Hager
authors.affiliation: Institut für Pathologie, Universitätsklinik Essen, Essen, Deutschland.
authors.forename: H A
authors.initials: HA
authors.lastname: Baba
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003324:Coronary Artery Disease / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology*
keywords: Acute coronary syndrome; Coronary atherosclerosis; Plaque rupture; Thrombosis; Vulnerable plaque