title: Association of inhibin-α gene polymorphisms with follicular cysts in large white sows.
abstract: Ovarian follicular cysts are anovulatory follicular structures that have been identified in sows and are known to cause infertility. The pathogenesis of follicular cysts remains poorly understood. Hormones play key roles in the formation and persistence of cysts. The hormone inhibin is a member of the TGF-β superfamily and is named for its negative regulation of FSH, another hormone that controls follicular recruitment and growth. In the present study, 48 sows with follicular cysts and 60 normal sows with no cysts were screened for mutations in the inhibin-α gene to examine the association of inhibin-α gene polymorphisms with the presence of follicular cysts. The results show that the c.-42G>A and c.3222G>A polymorphisms are significantly associated with follicular cysts and that sows with c.-42GG and c.3222GG genotypes have lower risk of developing cysts. Our findings may provide novel biological biomarkers and promising gene therapy candidates for follicular cyst formation in sows, which would greatly benefit pig breeding programs.
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Wanhong
authors.initials: W
authors.lastname: Li
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Lina
authors.initials: L
authors.lastname: Sun
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Shuxiong
authors.initials: S
authors.lastname: Chen
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Liu
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Hou
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Yamei
authors.initials: Y
authors.lastname: Han
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China; College of Animal Science and Veterinary Medicine, Liaoning Medical University, Jinzhou, Liaoning, P.R. China.
authors.forename: Chunqiang
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China. Electronic address: llcjj158@163.com.
authors.forename: Chunjin
authors.initials: C
authors.lastname: Li
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China. Electronic address: xzhou65@vip.sina.com.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000818:Animals; D004252:DNA Mutational Analysis; D005260:Female; D005497:Follicular Cyst / Q000235:genetics*; D015571:Follicular Fluid / Q000378:metabolism; D056726:Genetic Association Studies; D005838:Genotype; D007265:Inhibins / Q000235:genetics* / Q000378:metabolism; D006080:Ovarian Follicle / Q000473:pathology*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D013552:Swine / Q000235:genetics*
chemical_list: C094377:inhibin-alpha subunit; D007265:Inhibins
keywords: Follicular cyst; Inhibin α; Mutation; Sow