title: Mesenchymal stromal cells improve early lymphocyte recovery and T cell reconstitution after autologous hematopoietic stem cell transplantation in patients with malignant lymphomas.
abstract: Mesenchymal stromal cells (MSCs) possess a multi-lineage potential and immunoregulatory activities and provide a great potential in cell-based technologies. However, MSC suppressive activity raises concerns regarding the possible adverse effect of MSCs on the immune recovery. The influence of autologous MSC co-transplantation on recovery of T cell subsets in patients receiving autologous hematopoietic stem cell transplantation (AHSCT) for malignant lymphomas and multiple myeloma were characterized. Co-transplantation of MSCs improved lymphocyte recovery most effectively in patients with low input of hematopoietic stem cells or low absolute lymphocyte count in apheresis product. MSC co-transplantation improved early recovery of both memory and naive T cells with more prominent effect on naive CD4(+) T cells. Patients with MSC co-transplantation showed more effective reconstitution of recent thymic emigrants. These data indicate the positive impact of MSCs on immune reconstitution and note MSC co-transplantation is feasible to optimize the outcomes of AHSCT in malignant lymphoma patients.
authors.affiliation: Laboratory of Cellular Immunotherapy, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia. Electronic address: Ebatorov@gmail.com.
authors.forename: Egor V
authors.initials: EV
authors.lastname: Batorov
authors.affiliation: Laboratory of Cellular Immunotherapy, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Ekaterina Ya
authors.initials: EY
authors.lastname: Shevela
authors.affiliation: Laboratory of Cellular Immunotherapy, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Marina A
authors.initials: MA
authors.lastname: Tikhonova
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Dariya S
authors.initials: DS
authors.lastname: Batorova
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Galina Yu
authors.initials: GY
authors.lastname: Ushakova
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Sizikova
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Vera V
authors.initials: VV
authors.lastname: Sergeevicheva
authors.affiliation: Intensive Care Unit, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Gilevich
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Kryuchkova
authors.affiliation: Laboratory of Cellular Immunotherapy, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Alexandr A
authors.initials: AA
authors.lastname: Ostanin
authors.affiliation: Laboratory of Cellular Immunotherapy, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: Elena R
authors.initials: ER
authors.lastname: Chernykh
mesh_terms: D000293:Adolescent; D000328:Adult; D049109:Cell Proliferation; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology / Q000628:therapy; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: C508594:IL2 protein, human; D007376:Interleukin-2
keywords: Autologous hematopoietic stem cell transplantation; Homeostatic proliferation; Immune reconstitution; Malignant lymphomas; Mesenchymal stromal cells