title: A meta-analysis of MTRR A66G polymorphism and colorectal cancer susceptibility.
abstract: OBJECTIVE
  A meta-analysis was performed to determine the association between MTRR A66G polymorphism and colorectal cancer (CRC) susceptibility.
  
  
  METHODS
  Based on comprehensive searches of the MEDLINE, EMBASE and ISI Web of knowledge, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between MTRR A66G polymorphism and CRC susceptibility.
  
  
  RESULTS
  A total of 6020 cases and 8317 controls in 15 studies were pooled together for evaluation of the overall association between MTRR A66G polymorphism and susceptibility of CRC. The allele model (G vs A: p=0.01; OR=1.07, 95% CI=1.02-1.12), and homozygous model (GG vs AA: p=0.006; OR=1.15, 95% CI=1.04-1.28) showed increased risk for CRC development. Similarly, the dominant model (GG+GA vs AA: p=0.04; OR=1.11, 95% CI=1.01-1.22) and the recessive model (GG vs GA+AA: p=0.04; OR=1.08, 95% CI=1.00-1.17) showed increased risk for CRC development. In the analysis stratified by ethnicity (Caucasian and East Asian), significant associations were found between MTRR A66G polymorphism and susceptibility to CRC among Caucasians.
  
  
  CONCLUSIONS
  Our pooled data suggest an association between MTRR A66G polymorphism and CRC susceptibility among Caucasians.
authors.affiliation: Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing 210009, China.
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: Wu
authors.forename: Ri-Ning
authors.initials: RN
authors.lastname: Tang
authors.forename: Li
authors.initials: L
authors.lastname: An
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase