title: Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders.
abstract: Mutations in cardiotrophin-like cytokine factor (CLCF1) and the related cytokine to which it binds, cytokine receptor-like factor 1 (CRLF1), are associated with Crisponi/cold induced sweating syndromes, and lead to early neonatal death in mice due to a suckling defect. These cytokines are members of the IL-6 superfamily, and form a range of composite cytokines that signal through gp130 bound either to the ciliary neurotrophic factor receptor (CNTFR) or a complex that involves the IL-27 p28 subunit. This review describes current knowledge of the signalling complexes formed by these cytokines, and explores their described and suggested roles in the neural, haematopoietic, skeletal, renal, immune and respiratory systems during development and adulthood, and in degenerative diseases and cancer.
authors.affiliation: St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia; Department of Medicine, St. Vincent's Hospital Melbourne, The University of Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia. Electronic address: nsims@svi.edu.au.
authors.forename: Natalie A
authors.initials: NA
authors.lastname: Sims
mesh_terms: D000818:Animals; D053739:Ciliary Neurotrophic Factor Receptor alpha Subunit / Q000235:genetics / Q000276:immunology; D050822:Cytokine Receptor gp130 / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000276:immunology*; D003645:Death, Sudden; D019066:Facies; D005334:Fever / Q000235:genetics / Q000276:immunology*; D006228:Hand Deformities, Congenital / Q000235:genetics / Q000276:immunology*; D006801:Humans; D006945:Hyperhidrosis; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology*; D007378:Interleukins / Q000235:genetics / Q000276:immunology; D051379:Mice; D009119:Muscle Contraction / Q000235:genetics / Q000276:immunology; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D014313:Trismus / Q000151:congenital* / Q000235:genetics / Q000276:immunology
chemical_list: C000606074:CLCF1 protein, human; C548324:CNTFR protein, human; D053739:Ciliary Neurotrophic Factor Receptor alpha Subunit; D016207:Cytokines; C494199:IL6ST protein, human; D015850:Interleukin-6; D007378:Interleukins; C464565:MYDGF protein, human; D009363:Neoplasm Proteins; C486482:neuropoietin, mouse; D050822:Cytokine Receptor gp130
keywords: Cardiotrophin-like cytokine; Ciliary neurotrophic factor receptor; IL-6; Neuropoietin; STAT; gp130