title: Neonatal diabetes in Ukraine: incidence, genetics, clinical phenotype and treatment.
abstract: BACKGROUND
  Neonatal diabetes has not been previously studied in Ukraine. We investigated the genetic etiology in patients with onset of diabetes during the ﬁrst 9 months of life.
  
  
  METHODS
  We established a Pediatric Diabetes Register to identify patients diagnosed with diabetes before 9 months of age. Genetic testing was undertaken for 42 patients with permanent or transient diabetes diagnosed within the first 6 months of life (n=22) or permanent diabetes diagnosed between 6 and 9 months (n=20).
  
  
  RESULTS
  We determined the genetic etiology in 23 of 42 (55%) patients; 86% of the patients diagnosed before 6 months and 20% diagnosed between 6 and 9 months. The incidence of neonatal diabetes in Ukraine was calculated to be 1 in 126,397 live births.
  
  
  CONCLUSIONS
  Genetic testing for patients identified through the Ukrainian Pediatric Diabetes Register identified KCNJ11 and ABCC8 mutations as the most common cause (52%) of neonatal diabetes. Transfer to sulfonylureas improved glycemic control in all 11 patients.
authors.forename: Evgenia
authors.initials: E
authors.lastname: Globa
authors.forename: Nataliya
authors.initials: N
authors.lastname: Zelinska
authors.forename: Deborah J G
authors.initials: DJ
authors.lastname: Mackay
authors.forename: Karen I
authors.initials: KI
authors.lastname: Temple
authors.forename: Jayne A L
authors.initials: JA
authors.lastname: Houghton
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Hattersley
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Flanagan
authors.forename: Sian
authors.initials: S
authors.lastname: Ellard
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D005820:Genetic Testing; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D009154:Mutation; D010641:Phenotype; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics; D012042:Registries; D013453:Sulfonylurea Compounds / Q000627:therapeutic use; D064233:Sulfonylurea Receptors / Q000235:genetics; D014455:Ukraine / Q000453:epidemiology; D000099161:Kcnj11 Channel
chemical_list: D007004:Hypoglycemic Agents; D024661:Potassium Channels, Inwardly Rectifying; D013453:Sulfonylurea Compounds; D064233:Sulfonylurea Receptors; D000099161:Kcnj11 Channel; C577507:ABCC8 protein, human