title: Expression of virus-responsive genes and their response to challenge with poly(I:C) at different stages of the annual fish Nothobranchius guentheri: Implications for an asymmetric decrease in immunity.
abstract: Aging deteriorates immunity. However, if aging affects immunity in an asymmetric or symmetric way remains largely unknown. In this study we clearly demonstrate that compared with adult fish, the anti-viral responses of aged annual fish Nothobranchius guentheri, as reflected by the expression levels of virus-responsive genes, including lgp2 and mda5 encoding sensor molecules, ifn-i and viperin encoding the effector molecules and irf1, irf7, stat1 and atf3 encoding the regulation elements, are either reduced remarkably or elevated markedly or show little difference depending upon the different tissues. Moreover, although challenge with poly(I:C) results in a significant decrease in the expression of virus-responsive genes in most tissues of aged N. guentheri, it also causes a considerable increase in the expression of the genes in other tissues of aged fish. Collectively, these data suggest that the anti-viral responses of the annual fish N. guentheri generally reduces with age in an asymmetric way among the most tissues.
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, Qingdao 266003, China.
authors.forename: Shousheng
authors.initials: S
authors.lastname: Liu
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, Qingdao 266003, China; College of Life Science and Technology, Hong He University, Mengzi, Yunnan 661100, China.
authors.forename: Chengyan
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, Qingdao 266003, China.
authors.forename: Chuchu
authors.initials: C
authors.lastname: Duan
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, Qingdao 266003, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Hu
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, Qingdao 266003, China. Electronic address: sczhang@ouc.edu.cn.
authors.forename: Shicui
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000375:Aging / Q000235:genetics* / Q000276:immunology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D003532:Cyprinodontiformes / Q000235:genetics* / Q000276:immunology; D029941:Fish Proteins / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007369:Interferon Inducers / Q000494:pharmacology; D008297:Male; D011070:Poly I-C / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D029941:Fish Proteins; D007369:Interferon Inducers; D012333:RNA, Messenger; D011070:Poly I-C
keywords: Aging; Annual fish; Anti-virus response; Nothobranchius guentheri