title: A novel association between cerebral sinovenous thrombosis and nonketotic hyperglycinemia in a neonate.
abstract: Lethargy in newborns usually indicates central nervous system dysfunction, and many conditions such as cerebrovascular events, infections, and metabolic diseases should be considered in the differential diagnosis. Nonketotic hyperglycinemia is an autosomal recessive error of glycine metabolism, characterized by myoclonic jerks, hypotonia, hiccups, apnea, and progressive lethargy that may progress to encephalopathy or even death. Cerebral sinovenous thrombosis is a rare condition with various clinical presentations such as seizures, cerebral edema, lethargy, and encephalopathy. Here, we report the case of a newborn infant who presented with progressive lethargy. An initial diagnosis of cerebral venous sinus thrombosis was followed by confirmation of the presence of nonketotic hyperglycinemia.
authors.affiliation: Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
authors.forename: Sadık
authors.initials: S
authors.lastname: Yurttutan
authors.affiliation: Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
authors.forename: Mehmet Yekta
authors.initials: MY
authors.lastname: Oncel
authors.affiliation: Elmadağ State Hospital, Ankara, Turkey.
authors.forename: Nursel
authors.initials: N
authors.lastname: Yurttutan
authors.affiliation: Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Degirmencioglu
authors.affiliation: Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uras
authors.affiliation: Department of Pediatrics, Yıldırım Beyazıt University Hospital, Ankara, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
keywords: Cranial venous sinus thrombosis; Newborn; Nonketotic hyperglycinemia