title: Low-Grade Adenosquamous Carcinoma of the Breast Developing Around a Localization Wire Fragment.
abstract: We present the case of a 67-year-old white woman with a history of benign biopsy results in the previous 10 years before she developed low-grade adenosquamous carcinoma around a residual localization wire fragment. A possible theory of carcinogenesis may be related to reparative epithelium in a healing biopsy site that underwent squamous metaplasia; alternately, there may have been carcinogenesis related to long-term metal exposure at the wire placement site. In vitro and in vivo studies have demonstrated a link between carcinogenesis and long-term exposure to various metals. This case report raises important questions regarding carcinogenesis in the setting of long-term metal exposure and the reparative response of the body at the site of injury or biopsy.
authors.affiliation: Department of Radiology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Handa
authors.affiliation: Department of Cytopathology, Montefiore Medical Center, Bronx, NY.
authors.forename: Samer N
authors.initials: SN
authors.lastname: Khader
authors.affiliation: Department of Radiology, The Brooklyn Hospital, Brooklyn, NY.
authors.forename: Shalom S
authors.initials: SS
authors.lastname: Buchbinder
authors.affiliation: Department of Radiology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY mguelfguat@gmail.com.
authors.forename: Mark
authors.initials: M
authors.lastname: Guelfguat
mesh_terms: D000368:Aged; D001706:Biopsy / Q000009:adverse effects*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D018196:Carcinoma, Adenosquamous / Q000473:pathology* / Q000556:secondary*; D005260:Female; D006801:Humans; D008327:Mammography; D009364:Neoplasm Recurrence, Local
keywords: breast carcinoma; carcinogenesis; localization wire; mammography; metaplastic breast carcinoma; ultrasound