title: Successful reintroduction of statin therapy after statin-associated rhabdomyolysis.
abstract: The case report demonstrates the successful use of an alternative statin after a statin-related episode of rhabdomyolysis. Statin-associated rhabdomyolysis is a serious adverse event with a very low incidence and is considered the most severe of the muscle-related side effects of the statins. Rechallenge with statins is not a recommended practice after rhabdomyolysis. The patient experienced a myocardial infarct 1 y after the episode of rhabdomyolysis. He used alternative lipid-lowering therapy for 2 y. His low-density lipoprotein cholesterol was not meeting typical secondary prevention targets. An alternative statin was introduced and the patient has been followed for 4 years without recurrence of the rhabdomyolysis. This case suggests it may be time to reconsider the accepted practice of permanently avoiding statin therapy after rhabdomyolysis.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Janet E
authors.initials: JE
authors.lastname: Simons
authors.affiliation: Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Holbrook
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada. Electronic address: donwauc@mcmaster.ca.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Don-Wauchope
mesh_terms: D000069059:Atorvastatin / Q000008:administration & dosage / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage
chemical_list: D008055:Lipids; D000068718:Rosuvastatin Calcium; D000069059:Atorvastatin
keywords: Creatine kinase; HMG-CoA reductase inhibitors; Hyperlipidemia; Rhabdomyolysis; Serious adverse event; Statin