title: Unresectable Recurrent Squamous Cell Carcinoma of the Temporal Bone Treated by Induction Chemotherapy Followed by Concurrent Chemo-Reirradiation: A Case Report and Review of the Literature.
abstract: OBJECTIVE
  To report a rare case of recurrent temporal bone carcinoma encasing the carotid artery.
  
  
  METHODS
  A 54-year-old man underwent mastoidectomy combined with adjuvant chemoradiotherapy of squamous cell carcinoma of the temporal bone. He developed metastatic disease and received parotidectomy and lymph node dissection. Three months later, the magnetic resonance imaging scan showed that the tumor had relapsed and invaded the carotid artery.
  
  
  METHODS
  The patient completed TPF-C induction chemotherapy (docetaxel, cisplatin, 5-fluorouracil, cetuximab), followed by concurrent chemotherapy with reirradiation.
  
  
  RESULTS
  Magnetic resonance imaging revealed a complete response of tumor 1 month after treatment. The patient had no detectable recurrence after 53 months of follow-up.
  
  
  CONCLUSIONS
  Concurrent chemotherapy with reirradiation is a potential curative treatment option for patients who have unresectable recurrent squamous cell carcinoma of the temporal bone.
authors.affiliation: *Departments of Otolaryngology Head and Neck †Radiation Oncology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China.
authors.forename: Ma
authors.initials: M
authors.lastname: Kun
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xinxin
authors.forename: Zhao
authors.initials: Z
authors.lastname: Feifan
authors.forename: Ma
authors.initials: M
authors.lastname: Lin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D000068818:Cetuximab / Q000008:administration & dosage; D059248:Chemoradiotherapy / Q000379:methods; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D060828:Induction Chemotherapy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D000069475:Re-Irradiation / Q000379:methods; D012888:Skull Neoplasms / Q000473:pathology / Q000628:therapy*; D000077195:Squamous Cell Carcinoma of Head and Neck; D043823:Taxoids / Q000008:administration & dosage; D013701:Temporal Bone / Q000473:pathology*
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D000068818:Cetuximab; D002945:Cisplatin; D005472:Fluorouracil