title: Effect of Non-Surgical Periodontal Treatment on Clinical and Biochemical Risk Markers of Cardiovascular Disease: A Randomized Trial.
abstract: BACKGROUND
  Various studies have shown periodontal disease is one of the risk factors for coronary heart disease (CHD), and periodontal treatment of patients with CHD has also been correlated with reduction in systemic markers of CHD. The aim of this study is to evaluate the effect of non-surgical periodontal treatment (NSPT) on the cardiovascular clinical and biochemical status of patients with CHD.
  
  
  METHODS
  Seventy known patients with CHD were allocated randomly to either a control group (C; no periodontal therapy) (n = 35) or an experimental group (E; NSPT in the form of scaling and root planing [SRP]) (n = 35). Cardiovascular status was assessed using clinical parameters such as pulse, respiratory rate, blood pressure (BP), and biochemical parameters, such as high-sensitivity C-reactive protein (hsCRP), lipid profile, and white blood cell (WBC) count, at baseline and 1, 3, and 6 months. Intergroup and intragroup comparisons were performed using Student t test, and P <0.05 was considered statistically significant.
  
  
  RESULTS
  The complete data at the end of the study were provided by only 55 patients (group C, n = 25; group E, n = 30). Highly statistically significant reduction was observed in systolic BP (7.1 mm Hg) and very-low-density lipoproteins (VLDLs; 5.16 mg/dL) in group E. Changes were also observed in other cardiovascular biochemical and clinical parameters but were not statistically significant.
  
  
  CONCLUSIONS
  NSPT (in the form of SRP) positively affects limited cardiovascular (clinical and biochemical) status of patients with CHD. Reduction in triglyceride, VLDL, total WBC, lymphocyte, and neutrophil counts and increase in hsCRP, total cholesterol, high-density lipoprotein, and low-density lipoprotein levels were observed. Highly significant reduction in VLDL cholesterol levels and systolic BP was observed among the various parameters measured.
authors.affiliation: Department of Periodontology, Government College of Dentistry, Indore, Madhya Pradesh, India.
authors.forename: Divya Singh
authors.initials: DS
authors.lastname: Hada
authors.affiliation: Department of Periodontology, Government College of Dentistry, Indore, Madhya Pradesh, India.
authors.forename: Subhash
authors.initials: S
authors.lastname: Garg
authors.affiliation: Department of Medicine, Maharaja Yeshwantrao Hospital, Indore, Madhya Pradesh, India.|Department of Medicine, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India.
authors.forename: Girish B
authors.initials: GB
authors.lastname: Ramteke
authors.affiliation: Department of Periodontology, Government College of Dentistry, Indore, Madhya Pradesh, India.
authors.forename: Madhu Singh
authors.initials: MS
authors.lastname: Ratre
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein; D002318:Cardiovascular Diseases; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016745:Root Planing
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: C-reactive protein; coronary disease; periodontal debridement; periodontal diseases; randomized controlled trial; risk factors