title: High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss.
abstract: Idiopathic sudden sensorineural hearing loss (ISSHL) is a common otologic emergency whose cause is still unclear. The importance of blood lipids in the pathogenesis of ISSHL is widely reported in literature. In fact elevated levels of low density lipoprotein cholesterol (LDL), total cholesterol (TC) and apolipoprotein B (Apo-B) have been proposed as risk factors for this pathology. No correlation has been described between serum lipid parameters and the prognosis of ISSHL. Aim of the present study was to identify prognostic factors associated with hearing recovery in a group of patients affected by ISSHL. Ninety-four patients with the diagnosis of ISSHL hospitalized between March 2013 and October 2014 were included in this study. Patients' blood sampling and hearing assessments were carried out. Patients were divided into two groups as "recovered" and "unrecovered", according to their response to the treatment. We found a statistically significant higher level of total cholesterol in the unrecovered group compared to the recovered one (p = 0.03). None of the other routine laboratory parameters have shown a statistically significant difference between the patients successfully treated and patients with poor outcomes. Total cholesterol concentrations may be a prognostic factor for recovery in ISSHL and should be assessed together with routine tests in patients with this condition. The other routine laboratory parameters seem to have no effect on the development and prognosis of this pathology.
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari "Aldo Moro", 70124, Bari, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Quaranta
authors.affiliation: Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari "Aldo Moro", 70124, Bari, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Squeo
authors.affiliation: Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124, Bari, Italy.
authors.forename: Moris
authors.initials: M
authors.lastname: Sangineto
authors.affiliation: IRCCS Istituto Tumori Giovanni Paolo II, 70124, Bari, Italy.
authors.forename: Giusi
authors.initials: G
authors.lastname: Graziano
authors.affiliation: Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124, Bari, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Sabbà
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000097:blood* / Q000175:diagnosis / Q000534:rehabilitation*; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000175:diagnosis / Q000534:rehabilitation*; D006320:Hearing Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D002784:Cholesterol