title: Recent developments in silicones for topical and transdermal drug delivery.
abstract: Silicones have been used in medicines, cosmetics and medical devices for over 60 years. Polydimethylsiloxanes are polymers that are typically used either as an active in oral drug products or as excipients in topical and transdermal drug products. Inherent characteristics like hydrophobicity, adhesion and aesthetics allow silicones to offer function and performance to drug products. Recent technologies like swollen crosslinked silicone elastomer blend networks, sugar siloxanes, amphiphilic resin linear polymers and silicone hybrid pressure sensitive adhesives promise potential performance advantages and improved drug delivery efficacy. This article presents a review of recent silicone material developments focusing on their function as excipients influencing drug delivery in topical and transdermal systems.
authors.affiliation: Dow Corning Corporation, Midland, MI 48686, USA.
authors.forename: Hyder
authors.initials: H
authors.lastname: Aliyar
authors.affiliation: Dow Corning Corporation, Midland, MI 48686, USA.
authors.forename: Gerald
authors.initials: G
authors.lastname: Schalau
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004059:Diffusion of Innovation; D004337:Drug Carriers; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D012828:Silicones / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends*; D057968:Transdermal Patch
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D012828:Silicones