title: Quality of Life and Bronchial Hyper-Responsiveness in Subjects With Bronchiectasis: Validation of the Seattle Obstructive Lung Disease Questionnaire in Bronchiectasis.
abstract: BACKGROUND
  Bronchiectasis can adversely affect quality of life. However, the tests examining quality of life in bronchiectasis are not sufficient. We examined the validity of a measure designed for COPD, the Seattle Obstructive Lung Disease Questionnaire (SOLQ), in bronchiectasis. In addition, we aimed to compare the quality of life of subjects with bronchiectasis and bronchial hyper-responsiveness with that of those without to identify the effective factors.
  
  
  METHODS
  We studied 78 subjects with clinically stable bronchiectasis and 41 healthy controls matched for age and sex. Subjects were assessed by the SOLQ. A detailed history, physical examination, the Medical Outcomes Study 36-Item Short Form questionnaire, the Hospital Anxiety and Depression Scale, and spirometric measurements were obtained.
  
  
  RESULTS
  Cronbach α coefficients, which reflected internal consistency, were >0.70 for all SOLQ components except for treatment satisfaction. SOLQ component scores correlated with all of the component scores of the Medical Outcomes Study 36-Item Short Form questionnaire and the Hospital Anxiety and Depression Scale, confirming their concurrent validity. All SOLQ scores correlated positively with percent-of-predicted FEV1, whereas the physical function, treatment satisfaction, and emotional function correlated negatively with the exacerbation frequency in Pearson analysis. Emotional and physical functions were positively associated with percent-of-predicted FEV1 in linear regression analysis. Compared with subjects without bronchial hyper-responsiveness, those with bronchial hyper-responsiveness had lower FEV1/FVC and more exacerbations/y. Compared with bronchiectasis subjects without bronchial hyper-responsiveness, those with bronchial hyper-responsiveness had significantly lower SOLQ, physical function, and coping skills scores but not emotional function and treatment satisfaction.
  
  
  CONCLUSIONS
  The SOLQ is a valid instrument for determining quality of life in subjects with bronchiectasis. Subjects with bronchiectasis and bronchial hyper-responsiveness had a poorer quality of life, lower baseline spirometric values, and more frequent exacerbations, suggesting more severe disease.
authors.affiliation: Department of Pulmonary Diseases, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey. emelbulcun@hotmail.com.
authors.forename: Emel
authors.initials: E
authors.lastname: Bulcun
authors.affiliation: Department of Pulmonary Diseases, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Arslan
authors.affiliation: Department of Pulmonary Diseases, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Aydanur
authors.initials: A
authors.lastname: Ekici
authors.affiliation: Department of Pulmonary Diseases, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ekici
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D016535:Bronchial Hyperreactivity / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D001987:Bronchiectasis / Q000150:complications* / Q000503:physiopathology* / Q000523:psychology; D016022:Case-Control Studies; D018450:Disease Progression; D004644:Emotions; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014797:Vital Capacity
keywords: bronchial hyper-responsiveness; bronchiectasis; exacerbation number; health-related quality of life; spirometric values