title: Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
abstract: OBJECTIVE
  To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1 μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol.
  
  
  METHODS
  Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5·0-14·9 pmol/l; higher stratum: 15·0-44·9 pmol/l).
  
  
  METHODS
  Infertile women of good prognosis (n = 265).
  
  
  METHODS
  Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH.
  
  
  RESULTS
  Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P < 0·001) positive dose responses were observed for the number of follicles ≥ 12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose-response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients.
  
  
  CONCLUSIONS
  Dose-response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS.
authors.affiliation: IVI Valencia, Valencia, Spain.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Bosch
authors.affiliation: Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Nyboe Andersen
authors.affiliation: IU Dexeus, Barcelona, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Barri
authors.affiliation: IVI Madrid, Madrid, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: García-Velasco
authors.affiliation: Universitair Ziekenhuis, Gent, Belgium.
authors.forename: Petra
authors.initials: P
authors.lastname: de Sutter
authors.affiliation: IVI Sevilla, Sevilla, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Fernández-Sánchez
authors.affiliation: IVF CUBE SE, Prague, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Visnova
authors.affiliation: Global Biometrics, Global Clinical & Non-Clinical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark.
authors.forename: Bjarke M
authors.initials: BM
authors.lastname: Klein
authors.affiliation: Reproductive Health, Global Clinical & Non-Clinical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Mannaerts
authors.affiliation: Reproductive Health, Global Clinical & Non-Clinical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark.
authors.forename: Joan-Carles
authors.initials: JC
authors.lastname: Arce
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone