title: FTO Polymorphism rs9939609 Contributes to Weight Changes in Children With Celiac Disease on Gluten-Free Diet.
abstract: OBJECTIVE
  Studies of adults and children with celiac disease have reported an increased risk of overweight during gluten-free diet (GFD). The fat mass and obesity-associated gene (FTO) variant rs9939609 has been associated with increased risk of developing obesity in children and adults.
  
  
  METHODS
  In our study, we analyzed the effect of this variant on weight gain in a cohort of 280 children with celiac disease on GFD.
  
  
  RESULTS
  We found that after a mean follow-up time of 3.0 years on GFD, FTO polymorphism influenced significantly the mean change in body mass index z score (P = 0.01).
  
  
  CONCLUSIONS
  We conclude that the FTO gene contributes to determine weight changes in children with celiac disease on GFD.
authors.affiliation: *Department of the Woman, Child and of General and Specialized Surgery †Department of General Surgery, Second University of Naples, Naples, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Grandone
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Marzuillo
authors.forename: Grazia
authors.initials: G
authors.lastname: Cirillo
authors.forename: Rosanna
authors.initials: R
authors.lastname: Squitieri
authors.forename: Salvatore
authors.initials: S
authors.lastname: Tolone
authors.forename: Emanuele
authors.initials: E
authors.lastname: Miraglia del Giudice
authors.forename: Laura
authors.initials: L
authors.lastname: Perrone
authors.forename: Carlo
authors.initials: C
authors.lastname: Tolone
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics*; D002446:Celiac Disease / Q000178:diet therapy* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D055050:Diet, Gluten-Free / Q000009:adverse effects*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male; D009765:Obesity / Q000209:etiology; D050177:Overweight / Q000209:etiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012189:Retrospective Studies
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human