title: Systemic canine histoplasmosis: A case report from Ecuador.
abstract: Histoplasmosis is a zoonotic systemic mycosis caused by Histoplasma capsulatum. We report a case of a female canine, 4 years old, presenting multifocal lymphadenitis and skin and gingival lesions, in Ecuador. Based on cytological, histopathological, histochemical analyses, fungal culture and DNA sequencing of the ITS region of the fungus, the diagnosis confirmed the presence of H. capsulatum as the agent of infection. The treatment plan included ketoconazole with a satisfactory outcome.
authors.affiliation: Centro de Investigación Traslacional-Carrera de Medicina Veterinaria y Zootecnia, Facultad de Ciencias de la Salud, Universidad de las Américas, Av. Granados y Colimes, EC170125, Ecuador ; Histodiagnóstico Veterinario, Av. Eloy Alfaro N51-50 y Los Álamos, EC170505, Ecuador.
authors.forename: Julio R
authors.initials: JR
authors.lastname: Ortiz-Yépez
authors.affiliation: Unidad de Investigaciones en Biomedicina, Zurita&Zurita Laboratorios, Av. De la Prensa N49-221 y Manuel Valdivieso, EC170501, Ecuador.
authors.forename: David A
authors.initials: DA
authors.lastname: Ortega-Paredes
authors.affiliation: Unidad de Investigaciones en Biomedicina, Zurita&Zurita Laboratorios, Av. De la Prensa N49-221 y Manuel Valdivieso, EC170501, Ecuador.
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Barba
authors.affiliation: Unidad de Investigaciones en Biomedicina, Zurita&Zurita Laboratorios, Av. De la Prensa N49-221 y Manuel Valdivieso, EC170501, Ecuador.
authors.forename: Paola M
authors.initials: PM
authors.lastname: Mafla-Endara
authors.affiliation: Unidad de Investigaciones en Biomedicina, Zurita&Zurita Laboratorios, Av. De la Prensa N49-221 y Manuel Valdivieso, EC170501, Ecuador.
authors.forename: Jeannete
authors.initials: J
authors.lastname: Zurita
keywords: Canine; DNA sequencing; Ecuador; Histoplasma capsulatum; Systemic histoplasmosis