title: Neuroligin-2 and the tightrope of excitation/inhibition balance in the prefrontal cortex.
abstract: Excitation/inhibition imbalance is implicated in symptoms of neuropsychiatric disorders. We discuss a study by Liang et al. (Mol Psychiatry 20: 850-859, 2015) demonstrating that the conditional knockout of neuroligin-2, a postsynaptic adhesion protein, in the prefrontal cortex of adult mice results in alterations in inhibitory synaptic properties. However, behavioral impairments emerged prior to the development of detectable changes in excitation/inhibition ratio. This suggests there may be network-specific excitation/inhibition ratios, some of which are more vulnerable to disruption than others.
authors.affiliation: Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London; and.
authors.forename: Alice M S
authors.initials: AM
authors.lastname: Durieux
authors.affiliation: Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London; and.
authors.forename: Jamie
authors.initials: J
authors.lastname: Horder
authors.affiliation: Roche Pharmaceutical Research & Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland marija-magdalena.petrinovic@roche.com.
authors.forename: Marija M
authors.initials: MM
authors.lastname: Petrinovic
mesh_terms: D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal; D051379:Mice; D009419:Nerve Tissue Proteins; D017397:Prefrontal Cortex; D013569:Synapses
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D009419:Nerve Tissue Proteins; C098003:neuroligin 2
keywords: inhibition; neuroligin; neuropsychiatric disorders; synapse