title: Central and systemic inflammatory responses to thoracotomy - potential implications for acute and chronic postsurgical pain.
abstract: Chronic postsurgical pain (CPSP) may affect up to 70% of patients after surgery. Glial and immune mediators have been implicated in the pathogenesis of chronic postsurgical pain. Our objective was to study cerebrospinal fluid (CSF) and serum concentrations of IL-1β, IL-6, IL-8, IL-10, IFNγ and TNFα over a 72-hour period in patients undergoing a thoracotomy and oesophagectomy. Despite adequate pain control, thoracotomy was still associated with significant central and peripheral inflammation. This must be taken into consideration in planning future strategies to prevent CPSP.
authors.affiliation: Department of Pain Medicine, St. James's Hospital, Dublin, Ireland.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Talbot
authors.affiliation: Department of Pain Medicine, St. James's Hospital, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
authors.forename: Kevin F
authors.initials: KF
authors.lastname: McCarthy
authors.affiliation: Department of Pain Medicine, St. James's Hospital, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
authors.forename: Connail
authors.initials: C
authors.lastname: McCrory
mesh_terms: D059787:Acute Pain / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D059350:Chronic Pain / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D013908:Thoracotomy / Q000009:adverse effects* / Q000639:trends
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators
keywords: Cerebrospinal fluid; Chemokine; Chronic postsurgical pain; Glia; Interleukin