title: Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity.
abstract: Silicon-containing nanoparticles (NPs) are considered promising drug carriers for targeted drug delivery. In this study, we investigated the physical and chemical properties of silicon-containing NPs, including silica and organomodified silica NPs (SiO2NPs and OrSiO2NPs, respectively), with different surface modifications, with the aim of increasing drug-loading efficiency. In addition, we described the original synthesis methods of different sizes of OrSiO2NPs, as well as new hybrid OrSiO2NPs with a silica core (SiO2 + OrSiO2NPs). Animal experiments revealed that the silicon-containing NPs investigated were non-toxic, as evidenced by a lack of hemodynamic response after intravenous administration. Bioelimination studies showed rapid renal excretion of OrSiO2NPs. In drug release kinetics studies, adenosine was immobilized on SiO2NPs using three different approaches: physical adsorption, ionic, and covalent bonding. We observed that the rate of adenosine desorption critically depended on the type of immobilization; therefore, adenosine release kinetics can be adjusted by SiO2NP surface modification technique. Adsorption of adenosine on SiO2 + OrSiO2NPs resulted in a significant attenuation of adenosine-induced hypotension and bradycardia.
authors.affiliation: a Institute of Experimental Medicine, North-West Federal Medical Research Centre , Saint-Petersburg , Russian Federation .|b First Pavlov State Medical University of Saint Petersburg , Saint Petersburg , Russian Federation .
authors.forename: Dmitry L
authors.initials: DL
authors.lastname: Sonin
authors.affiliation: a Institute of Experimental Medicine, North-West Federal Medical Research Centre , Saint-Petersburg , Russian Federation .|b First Pavlov State Medical University of Saint Petersburg , Saint Petersburg , Russian Federation .
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Korolev
authors.affiliation: a Institute of Experimental Medicine, North-West Federal Medical Research Centre , Saint-Petersburg , Russian Federation .|c Chemical Faculty, St-Petersburg State University , St. Petersburg , Russian Federation , and.
authors.forename: Viktor N
authors.initials: VN
authors.lastname: Postnov
authors.affiliation: a Institute of Experimental Medicine, North-West Federal Medical Research Centre , Saint-Petersburg , Russian Federation .|c Chemical Faculty, St-Petersburg State University , St. Petersburg , Russian Federation , and.
authors.forename: Elena B
authors.initials: EB
authors.lastname: Naumysheva
authors.affiliation: a Institute of Experimental Medicine, North-West Federal Medical Research Centre , Saint-Petersburg , Russian Federation .
authors.forename: Evgenia I
authors.initials: EI
authors.lastname: Pochkaeva
authors.affiliation: a Institute of Experimental Medicine, North-West Federal Medical Research Centre , Saint-Petersburg , Russian Federation .|d St. Petersburg State Academy of Veterinary Medicine , St. Petersburg , Russian Federation.
authors.forename: Marina L
authors.initials: ML
authors.lastname: Vasyutina
authors.affiliation: a Institute of Experimental Medicine, North-West Federal Medical Research Centre , Saint-Petersburg , Russian Federation .|b First Pavlov State Medical University of Saint Petersburg , Saint Petersburg , Russian Federation .
authors.forename: Michael M
authors.initials: MM
authors.lastname: Galagudza
mesh_terms: D000327:Adsorption; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D012825:Silicon / Q000737:chemistry*; D012822:Silicon Dioxide / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide; D012825:Silicon
keywords: Adenosine; bioelimination; hybrid nanoparticle; organomodified silica; surface modification