title: HSV-I and the cellular DNA damage response.
abstract: Peter Wildy first observed genetic recombination between strains of HSV in 1955. At the time, knowledge of DNA repair mechanisms was limited, and it has only been in the last decade that particular DNA damage response (DDR) pathways have been examined in the context of viral infections. One of the first reports addressing the interaction between a cellular DDR protein and HSV-1 was the observation by Lees-Milleret al. that DNA-dependent protein kinase catalytic subunit levels were depleted in an ICP0-dependent manner during Herpes simplex virus 1 infection. Since then, there have been numerous reports describing the interactions between HSV infection and cellular DDR pathways. Due to space limitations, this review will focus predominantly on the most recent observations regarding how HSV navigates a potentially hostile environment to replicate its genome.
authors.affiliation: Department of Molecular Biology & Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Smith
authors.affiliation: Department of Molecular Biology & Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA.
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Weller
keywords: C-NHEJ; DDR; DNA damage response; HR; HSV-1; Herpes simplex virus 1; MMEJ; SSA; classic nonhomologous end-joining; homologous recombination; intrinsic antiviral defense; microhomology-mediated end joining; single-strand annealing; virally encoded recombinase; virus–host interactions