title: Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency - a prospective cohort study.
abstract: OBJECTIVE
  To investigate hepcidin during pregnancy, delivery and postpartum in women with sufficient iron supplementation.
  
  
  METHODS
  Hepcidin was measured using LC-MS spectroscopy in 37 women during pregnancy, delivery and postpartum period in this longitudinal study.
  
  
  RESULTS
  Hepcidin was low during pregnancy and increased at delivery and postpartum. No correlations with inflammatory markers or iron metabolism were observed during pregnancy; at delivery a correlation with inflammatory markers was observed.
  
  
  CONCLUSIONS
  During pregnancy, in women with sufficient iron supplementation, hepcidin is low and does not reflect iron status. During delivery and the postpartum period, hepcidin functions as a marker of inflammation.
authors.affiliation: a Department of Clinical Biochemistry , Copenhagen University Hospital Gentofte , Hellerup , Denmark and.
authors.forename: Katrine K
authors.initials: KK
authors.lastname: Hedengran
authors.affiliation: b Department of Clinical Chemistry, Laboratory of Medicine , Scania , Sweden.
authors.forename: Dick
authors.initials: D
authors.lastname: Nelson
authors.affiliation: a Department of Clinical Biochemistry , Copenhagen University Hospital Gentofte , Hellerup , Denmark and.
authors.forename: Malene R
authors.initials: MR
authors.lastname: Andersen
authors.affiliation: a Department of Clinical Biochemistry , Copenhagen University Hospital Gentofte , Hellerup , Denmark and.
authors.forename: Steen
authors.initials: S
authors.lastname: Stender
authors.affiliation: a Department of Clinical Biochemistry , Copenhagen University Hospital Gentofte , Hellerup , Denmark and.|b Department of Clinical Chemistry, Laboratory of Medicine , Scania , Sweden.
authors.forename: Pal B
authors.initials: PB
authors.lastname: Szecsi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood; D008137:Longitudinal Studies; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D064451:Hepcidins; D007501:Iron
keywords: Anemia; delivery; hepcidin 25; iron deficiency; pregnancy