title: Antioxidant vitamins status in children and young adults undergoing dialysis: A single center study.
abstract: Vitamin E and C are well-known antioxidant vitamins. Oxidative stress is common in chronic kidney diseases. We evaluated 43 dialysis subjects prospectively in a cross-sectional survey. Serum vitamin E concentration was checked in all subjects; 37 cases underwent blood sampling for measurement of serum vitamin C. The enrolled subjects consisted of 12 (27.9%) peritoneal dialysis (PD) and 25 (58.1%) hemodialysis (HD) patients. Six (13.9%) patients were switched from PD to HD or vice versa. Serum concentration of vitamin E was normal, low and high in 9 (20.9%), 31 (72%) and 3 (7.1%) patients, respectively. There were no significant differences regarding age, gender, modality and duration of dialysis, and characteristics of dialysis sessions, mean serum blood urea nitrogen, and albumin levels between vitamin E deficient cases with those with normal serum vitamin E concentration (P > 0.05 for all). The serum vitamin C levels were low in 5 (13.5%) and normal in 32 (86.5%) patients. vitamin C deficiency was more prevalent in HD versus continuous ambulatory peritoneal dialysis patients (P = 0.128). Mean serum vitamin C concentration was higher in patients who were supplemented by vitamin C compared with those who didn't receive the vitamin supplement (P = 0.043). Vitamin E deficiency was a prevalent finding and supplementary vitamin C 30-60 mg/day was sufficient to prevent deficiency. Regular assessments of serum vitamin E level may be needed in dialysis centers.
authors.affiliation: Department of Pediatric Nephrology, Dr. Sheikh Children Hospital, Mashhad, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Naseri
authors.affiliation: Department of Pediatric Cardiology, Imam Reza Hospital, Mashhad, Iran.
authors.forename: H Motaghi Moghadam
authors.initials: HM
authors.lastname: Shahri
authors.affiliation: Department of Pediatric Cardiology, Imam Reza Hospital, Mashhad, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Horri
authors.affiliation: Hemodialysis Section, Dr. Sheikh Children Hospital, Mashhad, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Rasoli
authors.affiliation: CAPD Section, Dr. Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Salemian
authors.affiliation: Hemodialysis Section, Dr. Sheikh Children Hospital, Mashhad, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Jahanshahi
authors.affiliation: Hemodialysis Section, Dr. Sheikh Children Hospital, Mashhad, Iran.
authors.forename: G
authors.initials: G
authors.lastname: Moeenolroayaa
authors.affiliation: Hemodialysis Section, Dr. Sheikh Children Hospital, Mashhad, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Pourhasan
keywords: Continuous ambulatory peritoneal dialysis; Vitamin C; Vitamin E; hemodialysis