title: Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry.
abstract: BACKGROUND
  Drug addiction is influenced by genetic factors.
  
  
  OBJECTIVE
  To determine if genetic variants in the serotonergic and adrenergic pathways are associated with heroin and/or cocaine addiction.
  
  
  METHODS
  The study examined 140 polymorphisms in 19 genes in 1855 subjects with predominantly European or African ancestries.
  
  
  RESULTS
  A total of 38 polymorphisms (13 genes) showed nominal associations, including novel associations in S100A10 (p11) and SLC18A2 (VMAT2). The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p(corrected) = 0.04).
  
  
  CONCLUSIONS
  The study strengthens our previous findings of association of polymorphisms in HTR3A, HTR3B and ADRA1A. The study suggests partial overlap in genetic susceptibility between populations of different ancestry and between heroin and cocaine addiction.
authors.affiliation: The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Orna
authors.initials: O
authors.lastname: Levran
authors.affiliation: The Dr Miriam & Sheldon G Adelson Clinic for Drug Abuse Treatment & Research, Tel Aviv Elias Sourasky Medical Center, Tel Aviv, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Einat
authors.initials: E
authors.lastname: Peles
authors.affiliation: The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Randesi
authors.affiliation: Center for Clinical & Translational Science, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Correa da Rosa
authors.affiliation: Institute of Psychology, Chinese Academy of Sciences, Beijing, China.|The Laboratory of Statistical Genetics, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Jurg
authors.initials: J
authors.lastname: Ott
authors.affiliation: VA New York Harbor Healthcare System & NYU School of Medicine, New York, NY 10010, USA.
authors.forename: John
authors.initials: J
authors.lastname: Rotrosen
authors.affiliation: The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.|The Dr Miriam & Sheldon G Adelson Clinic for Drug Abuse Treatment & Research, Tel Aviv Elias Sourasky Medical Center, Tel Aviv, Israel.|Dr Miriam & Sheldon G Adelson Clinic for Drug Abuse Treatment & Research, Las Vegas, NV 89169, USA.
authors.forename: Miriam
authors.initials: M
authors.lastname: Adelson
authors.affiliation: The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Mary Jeanne
authors.initials: MJ
authors.lastname: Kreek
mesh_terms: D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D019970:Cocaine-Related Disorders / Q000235:genetics*; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006556:Heroin Dependence / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011941:Receptors, Adrenergic / Q000235:genetics*; D012701:Serotonin / Q000235:genetics*; D044465:White People / Q000235:genetics; D001741:Black or African American
chemical_list: D011941:Receptors, Adrenergic; D012701:Serotonin
keywords: ADRA1A; African–American; HTR3A; HTR3B; S100A10; SLC18A2; SLC6A4; adrenergic pathway; association study; cocaine addiction; genetic variants; heroin addiction; serotonergic pathway; stress