title: 7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders.
abstract: Neurodevelopmental disorders are a group of conditions that arises from impairments of the central nervous system during its development. The causes of the various disorders are heterogeneous and the symptoms likewise are multifarious. Most of these disorders currently have very little available treatment that is effective in combating the plethora of serious symptoms. Brain-derived neurotrophic factor (BDNF) is a fundamental neurotrophin with vital functions during brain development. Pre-clinical studies have shown that increasing BDNF signalling may be a potent way to prevent, arrest or even reverse abnormal neurodevelopmental events arising from a variety of genetic or environmental causes. However, many difficulties make BDNF problematic to administer in an efficient manner. The recent discovery of a small BDNF-mimetic, the naturally occurring flavonoid 7,8-dihydroxyflavone (7,8-DHF), may provide an avenue to allow efficient and safe activation of the BDNF pathway in tackling the symptoms of neurodevelopmental disorders. Here, evidence will be provided to support the potential of 7,8-DHF as a novel treatment for several neurodevelopmental disorders where the BDNF signalling pathway is implicated in the pathophysiology and where benefits are therefore most likely to be derived from its implementation.
authors.affiliation: Psychoneuroendocrinology Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: xin.du@florey.edu.au.
authors.forename: X
authors.initials: X
authors.lastname: Du
authors.affiliation: Psychoneuroendocrinology Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: R A
authors.initials: RA
authors.lastname: Hill
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D047309:Flavones / Q000008:administration & dosage*; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism; D065886:Neurodevelopmental Disorders / Q000188:drug therapy* / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D016896:Treatment Outcome
chemical_list: C485383:6,7-dihydroxyflavone; D019208:Brain-Derived Neurotrophic Factor; D047309:Flavones; D009414:Nerve Growth Factors; C579455:BDNF protein, human
keywords: 7,8-dihydroxyflavone; BDNF; Cognition; Flavonoids; Neurodevelopmental disorders; TrkB