title: Endogenous Endophthalmitis in Patients with MRSA Septicemia: A Case Series and Review of Literature.
abstract: OBJECTIVE
  To report the presentation, predisposing factors, clinical features and outcome in 6 eyes of 3 patients with endogenous endophthalmitis secondary to methicillin resistant staphylococcus aureus (MRSA) septicaemia.
  
  
  METHODS
  Retrospective review of case records of 3 patients who were treated for endogenous endophthalmitis secondary to MRSA septicaemia in a tertiary referral institution.
  
  
  RESULTS
  All three patients had systemic predisposition to endogenous endophthalmitis (diabetes, urosepsis). Two patients presented within 1 week of onset of visual symptoms and the third after 3 months. Blood culture was positive for MRSA in all patients. Visual and anatomical improvement was noted in two patients who presented early. The third patient's visual outcome despite early treatment with intravitreal antibiotics and vitrectomy was not satisfactory.
  
  
  CONCLUSIONS
  Endogenous endophthalmitis by MRSA is a rare but serious condition. Early and specific therapy based on reliable detection of the underlying microorganism is needed for good anatomical and functional outcome.
authors.affiliation: a Department of Ophthalmology , Kasturba Medical College , Manipal University, Madhav Nagar , Manipal , India and.
authors.forename: Shailaja Bhat
authors.initials: SB
authors.lastname: Shenoy
authors.affiliation: a Department of Ophthalmology , Kasturba Medical College , Manipal University, Madhav Nagar , Manipal , India and.
authors.forename: Meena
authors.initials: M
authors.lastname: Thotakura
authors.affiliation: a Department of Ophthalmology , Kasturba Medical College , Manipal University, Madhav Nagar , Manipal , India and.
authors.forename: Yogish
authors.initials: Y
authors.lastname: Kamath
authors.affiliation: b Department of Medicine , Kasturba Medical College , Manipal University, Madhav Nagar , Manipal , India.
authors.forename: Ragini
authors.initials: R
authors.lastname: Bekur
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000382:microbiology*; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D062606:Tertiary Care Centers; D014821:Vitrectomy
chemical_list: D000900:Anti-Bacterial Agents
keywords: Endogenous endophthalmitis; MRSA; intravitreal antibiotics; septicemia; vitrectomy