title: Protein nanoparticles for therapeutic protein delivery.
abstract: Therapeutic proteins can face substantial challenges to their activity, requiring protein modification or use of a delivery vehicle. Nanoparticles can significantly enhance delivery of encapsulated cargo, but traditional small molecule carriers have some limitations in their use for protein delivery. Nanoparticles made from protein have been proposed as alternative carriers and have benefits specific to therapeutic protein delivery. This review describes protein nanoparticles made by self-assembly, including protein cages, protein polymers, and charged or amphipathic peptides, and by desolvation. It presents particle fabrication and delivery characterization for a variety of therapeutic and model proteins, as well as comparison of the features of different protein nanoparticles.
authors.affiliation: School of Chemical & Biomolecular Engineering. Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332-0100, USA. julie.champion@chbe.gatech.edu.
authors.forename: L P
authors.initials: LP
authors.lastname: Herrera Estrada
authors.forename: J A
authors.initials: JA
authors.lastname: Champion
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D010455:Peptides; D011506:Proteins