title: Lipid-coated polymeric nanoparticles for cancer drug delivery.
abstract: Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid-polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic.
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore. julianachan@ntu.edu.sg.
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Krishnamurthy
authors.forename: Rajendran
authors.initials: R
authors.lastname: Vaiyapuri
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
authors.forename: Juliana M
authors.initials: JM
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008055:Lipids; D011108:Polymers