title: Myocardial protection from ischemia-reperfusion injury post coronary revascularization.
abstract: Effective primary and secondary prevention and advances in cardiac surgery have significantly improved the care and outcomes of patients with myocardial ischemia. While timely reperfusion has proved to be an invaluable tool, ischemia-reperfusion injury represents a mechanism that may limit its effectiveness. Numerous experimental studies have shown effective protection from ischemia-reperfusion injury in animal models, but translation into clinical practice has been less successful. This article summarizes the role of ischemia-reperfusion injury in the pathophysiology of ischemic heart disease and gives an overview of the various modalities that have been developed in order to provide myocardial protection from reperfusion injury in clinical practice.
authors.affiliation: a 1 Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Binder
authors.forename: Asghar
authors.initials: A
authors.lastname: Ali
authors.forename: Raveen
authors.initials: R
authors.lastname: Chawla
authors.forename: Hammad A
authors.initials: HA
authors.lastname: Aziz
authors.forename: Antonio
authors.initials: A
authors.lastname: Abbate
authors.forename: Ion S
authors.initials: IS
authors.lastname: Jovin
mesh_terms: D002316:Cardiotonic Agents / Q000627:therapeutic use; D016923:Cell Death / Q000502:physiology; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015425:Myocardial Reperfusion / Q000009:adverse effects; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D002316:Cardiotonic Agents
keywords: acute myocardial infarction; cardiac surgery; ischemia–reperfusion injury; myocardial protection; percutaneous coronary intervention; postconditioning; preconditioning