title: SNCA rs3822086 C>T Polymorphism Increases the Susceptibility to Parkinson's Disease in a Chinese Han Population.
abstract: OBJECTIVE
  Protofibrils of alpha-synuclein mediate neuronal cell death and propagate Parkinson's disease (PD). In this study, we investigated the relationship between the rs3822086 C>T polymorphism located in the fourth intron of the alpha-synuclein (SNCA) gene and susceptibility to PD in a Chinese Han population.
  
  
  METHODS
  146 PD patients and 144 sex- and age-matched healthy individuals (control group) were selected for this study. The SNCA rs3822086 polymorphism was examined in all 300 study subjects by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
  
  
  RESULTS
  The genotype and allele frequencies of the SNCA rs3822086 polymorphism showed significant differences between the PD group and control group (TT: 25.3% vs. 18.8%, p=0.035; CT+TT: 77.4% vs. 66.0%, p=0.031; T allele: 51.4% vs. 42.4%, p=0.030; respectively). Stratified analyses based on gender indicated that male PD patients exhibited higher genotype and allele frequencies of the SNCA rs3822086 polymorphism compared to healthy male controls (TT: 26.7% vs. 13.2%, p=0.011; CC+CT: 73.3% vs. 86.8%, p=0.024; T allele: 51.2% vs. 37.9%, p=0.012; respectively). Age-stratified analyses indicated that the genotype and allele frequencies of the SNCA rs3822086 polymorphism were significantly higher in PD patients older than 60 years in comparison to healthy controls (TT: 32.2% vs. 20.5%, p=0.014; CT+TT: 77.0% vs. 60.2%, p=0.017; T allele: 54.6% vs. 40.3%, p=0.008; respectively).
  
  
  CONCLUSIONS
  Our findings demonstrate that the SNCA rs3822086 C>T polymorphism correlates with increased susceptibility to PD among the Chinese Han population.
authors.affiliation: 1 Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities , Baise, China .|2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Chong-Dong
authors.initials: CD
authors.lastname: Jian
authors.affiliation: 1 Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities , Baise, China .
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Huang
authors.affiliation: 1 Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities , Baise, China .
authors.forename: Lan-Qing
authors.initials: LQ
authors.lastname: Meng
authors.affiliation: 1 Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities , Baise, China .
authors.forename: Xue-Bin
authors.initials: XB
authors.lastname: Li
authors.affiliation: 1 Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities , Baise, China .
authors.forename: Rui-Ya
authors.initials: RY
authors.lastname: Huang
authors.affiliation: 2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Sheng-Liang
authors.initials: SL
authors.lastname: Shi
authors.affiliation: 2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: 2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Chao
authors.initials: C
authors.lastname: Qin
authors.affiliation: 2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.affiliation: 2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: 2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.affiliation: 2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Yin-Ling
authors.initials: YL
authors.lastname: Feng
authors.affiliation: 2 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University , Nanning, China .
authors.forename: Sheng-Nian
authors.initials: SN
authors.lastname: Zhou
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: C497604:SNCA protein, human; D051844:alpha-Synuclein