title: Continuous inhaled iloprost in a neonate with d-transposition of the great arteries and severe pulmonary arterial hypertension.
abstract: This report describes the case of a neonate with d-transposition of the great arteries and severe pulmonary arterial hypertension stabilised in the post-operative period with continuous iloprost nebulisation. To our knowledge, this is the first documented method of treating post-operative severe pulmonary arterial hypertension with continuous inhaled iloprost in a patient with complex CHD. We found this method of delivering the drug very effective in stabilising haemodynamic swings in the setting of severe pulmonary arterial hypertension.
authors.affiliation: Nicklaus Children's Hospital,Department of Cardiology,Miami,Florida,United States of America.
authors.forename: John C
authors.initials: JC
authors.lastname: Dykes
authors.affiliation: Nicklaus Children's Hospital,Department of Cardiology,Miami,Florida,United States of America.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Torres
authors.affiliation: Nicklaus Children's Hospital,Department of Cardiology,Miami,Florida,United States of America.
authors.forename: Plato J
authors.initials: PJ
authors.lastname: Alexander
mesh_terms: D000280:Administration, Inhalation; D001158:Arteries / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D016285:Iloprost / Q000008:administration & dosage*; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000008:administration & dosage*; D014188:Transposition of Great Vessels / Q000601:surgery*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide; D016285:Iloprost
keywords: CHD; Inhaled iloprost; pulmonary arterial hypertension; transposition of the great arteries