title: [A case of acute disseminated encephalomyelitis (ADEM) with an anti-galactocerebroside antibody].
abstract: Acute disseminated encephalomyelitis (ADEM) with an anti-galactocerebroside antibody is very rare. We report a case of 82-year-old man with ADEM associated with anti-galactocerebroside antibody in serum. He was admitted to our hospital after developing disturbed consciousness and respiratory failure. A cerebrospinal fluid examination disclosed an albuminocytologic dissociation and elevation of myelin basic protein. Magnetic resonance images revealed lesions in the medulla oblongata, pons, midbrain, bilateral cerebellar hemisphere and thalami. Initially, he was treated with methylprednisolone (1 g/day) for three days. His clinical symptoms improved. We found on 15(th) hospital day that an anti-galactocerebroside antibody was positive in serum without serological evidence of Mycoplasma pneumoniae infection. This case can be diagnosed as ADEM associated with an anti-galactocerebroside antibody.
authors.affiliation: Department of Neurology, Chikamori Hospital.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kuzume
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Sajima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kon-no
authors.forename: Keiko
authors.initials: K
authors.lastname: Kaneko
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamasaki
mesh_terms: D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis*; D004673:Encephalomyelitis, Acute Disseminated / Q000276:immunology*; D005699:Galactosylceramides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male
chemical_list: D000906:Antibodies; D005699:Galactosylceramides; D007074:Immunoglobulin G; C002454:galactocerebroside