title: Wound healing: a new perspective on glucosylated tetrahydrocurcumin.
abstract: Wound healing represents a dynamic set of coordinated physiological processes observed in response to tissue injury. Several natural products are known to accelerate the process of wound healing. Tetrahydrocurcumin (THC), an in vivo biotransformed product/metabolite of curcumin, is known to exhibit a wide spectrum of biological activities similar to those of native curcuminoids. The poor bioavailability of these curcuminoids limits their clinical applications. The present study highlights the percutaneous absorption and wound healing activity of glucosyl-conjugated THC (glucosyl-THC) in male Wistar rats. A high plasma concentration of glucosyl-THC (4.35 μg/mL) was found in rats 3 hours after application. A significant enhanced wound healing activity and reduced epithelialization time were observed in rats that received glucosyl-THC. This may have been due to the improved bioavailability of the glucosyl compound. The nonstaining and lack of skin-sensitive side effects render the bioconjugated glucosyl-THC a promising therapeutic compound in the management of excision wounds and in cosmetic applications, in the near future.
authors.affiliation: Medicinal Chemistry and Pharmacology Division, Council of Scientific and Industrial Research - Indian Institute of Chemical Technology, Hyderabad, AP, India.
authors.forename: Adari
authors.initials: A
authors.lastname: Bhaskar Rao
authors.affiliation: Medicinal Chemistry and Pharmacology Division, Council of Scientific and Industrial Research - Indian Institute of Chemical Technology, Hyderabad, AP, India.
authors.forename: Ernala
authors.initials: E
authors.lastname: Prasad
authors.affiliation: Medicinal Chemistry and Pharmacology Division, Council of Scientific and Industrial Research - Indian Institute of Chemical Technology, Hyderabad, AP, India.
authors.forename: Seelam Siva
authors.initials: SS
authors.lastname: Deepthi
authors.affiliation: Medicinal Chemistry and Pharmacology Division, Council of Scientific and Industrial Research - Indian Institute of Chemical Technology, Hyderabad, AP, India.
authors.forename: Vennapusa
authors.initials: V
authors.lastname: Haritha
authors.affiliation: Medicinal Chemistry and Pharmacology Division, Council of Scientific and Industrial Research - Indian Institute of Chemical Technology, Hyderabad, AP, India.
authors.forename: Sistla
authors.initials: S
authors.lastname: Ramakrishna
authors.affiliation: Medicinal Chemistry and Pharmacology Division, Council of Scientific and Industrial Research - Indian Institute of Chemical Technology, Hyderabad, AP, India.
authors.forename: Kuncha
authors.initials: K
authors.lastname: Madhusudan
authors.affiliation: Pathology Division, National Institute of Nutrition, Hyderabad, AP, India.
authors.forename: Mullapudi Venkata
authors.initials: MV
authors.lastname: Surekha
authors.affiliation: Ashian Herbex Ltd, Hyderabad, AP, India.
authors.forename: Yerramilli Sri Rama
authors.initials: YS
authors.lastname: Venkata Rao
mesh_terms: D000818:Animals; D001682:Biological Availability; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006031:Glycosylation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption; D014945:Wound Healing / Q000187:drug effects*
chemical_list: C096277:tetrahydrocurcumin; D003474:Curcumin
keywords: cosmetic; epithelialization; glucosylation; granulation tissue; therapeutic