title: Involvenflavones A-F, six new flavonoids with 3'-aryl substituent from Selaginella involven.
abstract: Six new flavonoids, involvenflavones A-F (1-6), were isolated from Selaginella involven. Their structures were elucidated based on UV, IR, 1D and 2D NMR as well as HR-ESI-MS techniques. All compounds belong to apigenin derivatives with 3'-aryl substituent. This is the first report of the apigenin derivatives with 3'-aryl substituent from nature resources. These compounds also exhibited a potent effect against the injury of human umbilical vein endothelial cell (HUVECs) induced by high concentrations of glucose in vitro.
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: Long
authors.affiliation: The Medical College of Hunan Normal University, Changsha 410013, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zou
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Fu-Shuang
authors.initials: FS
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Luo
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Zhen-Xing
authors.initials: ZX
authors.lastname: Zou
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Chang-Ping
authors.initials: CP
authors.lastname: Hu
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China. Electronic address: xukp376@aliyun.com.
authors.forename: Kang-Ping
authors.initials: KP
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China; Xiangya Hospital of Central South University, Changsha 410008, PR China. Electronic address: tgs395@csu.edu.cn.
authors.forename: Gui-Shan
authors.initials: GS
authors.lastname: Tan
mesh_terms: D047310:Apigenin / Q000737:chemistry* / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D032503:Selaginellaceae / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D047310:Apigenin
keywords: Apigenin derivatives; Flavonoids; HUVECs; Selaginella; Selaginella involven