title: [Clinical usefulness of triazole derivatives in the management of fungal infections].
abstract: Current therapy for mycoses is limited to the use of a relative reduced number of antifungal drugs. Although amphotericin B still remains considered as the "gold standard" for treatment, acute and chronic toxicity, such as impairment of renal function, limits its use and enhances the investigation and clinical use other chemical families of antifungal drugs. One of these chemical class of active drugs are azole derivatives, discovered in 70s and introduced in clinical practice in 80s. Being the most prolific antifungal class, investigation about more molecules, with a safer and better pharmacological profile, active against a wide spectrum of fungi, with a wide range of administration routes gives us some azole representatives.
authors.affiliation: Alfonso Javier Carrillo-Muñoz. Apdo. Postal 10178. E-08080 Barcelona. Spain. acarrillo@aciam.es.
authors.forename: Alfonso Javier
authors.initials: AJ
authors.lastname: Carrillo-Muñoz
authors.forename: Gustavo
authors.initials: G
authors.lastname: Giusiano
authors.forename: Alicia
authors.initials: A
authors.lastname: Arechavala
authors.forename: Cristina
authors.initials: C
authors.lastname: Tur-Tur
authors.forename: Elena
authors.initials: E
authors.lastname: Eraso
authors.forename: Nerea
authors.initials: N
authors.lastname: Jauregizar
authors.forename: Guillermo
authors.initials: G
authors.lastname: Quindós
authors.forename: Ricardo
authors.initials: R
authors.lastname: Negroni
mesh_terms: D058888:14-alpha Demethylase Inhibitors / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D026141:Drug Resistance, Multiple, Fungal; D005656:Fungal Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D009181:Mycoses / Q000188:drug therapy*; D050603:Squalene Monooxygenase / Q000037:antagonists & inhibitors; D058886:Sterol 14-Demethylase / Q000187:drug effects; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D058888:14-alpha Demethylase Inhibitors; D000935:Antifungal Agents; D005656:Fungal Proteins; D014230:Triazoles; D058886:Sterol 14-Demethylase; D050603:Squalene Monooxygenase