title: The relation between the effect of a subhypnotic dose of thiopental on claw pain threshold in rats and adrenalin, noradrenalin and dopamine levels.
abstract: Thiopental sodium (TPS) needs to be applied together with adrenalin in order to establish its analgesic effect in general anesthesia. We aimed to investigate the effect of TPS on the claw pain threshold in rats and evaluated its relationship with endogenous adrenalin (ADR), noradrenalin (NDR), and dopamine (DOP) levels. Intact and adrenalectomized rats were used in the experiment. Intact animals were divided into the following groups: 15 mg/kg TPS (TS), 0.3 mg/kg ADR+15 mg/kg TPS (ATS) and 0.3 mg/kg ADR alone (ADR). Adrenalectomized animals were divided into the following groups: 15 mg/kg TPS (A-TS), 0.3 mg/kg ADR+15 mg/kg TPS (A-ATS) and 0.3 mg/kg ADR alone (A-ADR). Claw pain threshold and blood ADR, NDR, and DOP levels were measured. The TS group's claw pain threshold was found low. However, the claw pain thresholds of the ATS and ADR groups increased significantly. In the A-TS group, the pain threshold decreased compared with normal, and in the A-ATS and A-ADR groups, the pain threshold increased. TPS reduced the blood ADR levels in intact rats; however, no significant changes were observed in the NDR and DOP levels. #TPS provides hyperalgesia by reducing the production of ADR in rats. The present study shows that to achieve analgesic activity, TPS needs to be applied together with ADR.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25240, #Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aksoy
authors.forename: Ali
authors.initials: A
authors.lastname: Ahiskalioglu
authors.forename: Ilker
authors.initials: I
authors.lastname: Ince
authors.forename: Mine
authors.initials: M
authors.lastname: Celik
authors.forename: Aysenur
authors.initials: A
authors.lastname: Dostbil
authors.forename: Ufuk
authors.initials: U
authors.lastname: Kuyrukluyildiz
authors.forename: Durdu
authors.initials: D
authors.lastname: Altuner
authors.forename: Nezahat
authors.initials: N
authors.lastname: Kurt
authors.forename: Halis
authors.initials: H
authors.lastname: Suleyman
mesh_terms: D000315:Adrenalectomy; D000700:Analgesics / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000097:blood*; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000008:administration & dosage* / Q000097:blood*; D006724:Hoof and Claw / Q000502:physiology*; D006930:Hyperalgesia / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D017288:Pain Threshold / Q000187:drug effects*; D017208:Rats, Wistar; D013874:Thiopental / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D013874:Thiopental; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine