title: Seizure Recurrence in Developmentally and Neurologically Normal Children With a Newly Diagnosed Unprovoked Seizure.
abstract: This study aims to assess recurrence risk in developmentally and neurologically normal children with a newly diagnosed unprovoked seizure. The medical record was retrospectively reviewed in 393 children who had a newly diagnosed, unprovoked seizure. A total of 152 children met inclusion criteria. The relationship between seizure recurrence and variables was examined. Seventy cases had recurrent seizures. Total 113 cases had follow-up data and 70 cases of these (63.7%) experienced recurrent seizures. EEG was abnormal in 65 (44.8%): focal epileptiform abnormality in 34 cases (23.4%) and generalized epileptiform abnormality in 23 cases (15.9%). Brain MRI revealed any structural abnormality in 14 of 86 cases (16.3%). Neither EEG abnormality nor brain MRI abnormality was statistically significantly associated with increased seizure recurrence in this cohort. Further study is required to confirm the EEG and brain MRI findings in otherwise normal children with a newly diagnosed unprovoked seizure.
authors.affiliation: Pediatric Neurology, Emory University School of Medicine, Atlanta, GA, USA Children's Healthcare of Atlanta, Atlanta, GA, USA hyunmi.kim@emory.edu.
authors.forename: Hyunmi
authors.initials: H
authors.lastname: Kim
authors.affiliation: Children's Healthcare of Atlanta, Atlanta, GA, USA.
authors.forename: Ahyuda
authors.initials: A
authors.lastname: Oh
authors.affiliation: Rollins School of Public Health, Emory University, Atlanta, GA, USA.
authors.forename: Xinyao
authors.initials: X
authors.lastname: de Grauw
authors.affiliation: Pediatric Neurology, Emory University School of Medicine, Atlanta, GA, USA Children's Healthcare of Atlanta, Atlanta, GA, USA.
authors.forename: Ton J
authors.initials: TJ
authors.lastname: de Grauw
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D012008:Recurrence; D012640:Seizures / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology
keywords: children; developmentally normal; newly diagnosed; seizure recurrence; unprovoked seizure