title: Effects of platelet-rich fibrin and piezosurgery on impacted mandibular third molar surgery outcomes.
abstract: BACKGROUND
  The aim of this study was the comparision of postoperative outcomes in impacted mandibular third molars that were treated using either platelet-rich fibrin (PRF), a combination of PRF and piezosurgery, or conventional rotatory osteotomy.
  
  
  METHODS
  The study included 20 patients; 40 extractions of impacted mandibular third molars were performed. Patients were divided into two main groups. In group A (n = 20), traditional surgery was performed on one side (Group 1, n = 10); traditional surgery was performed, and PRF was administered to the extracted socket on the other side of same patient (Group 2, n = 10). In group B (n = 20), on one side, piezosurgery was used for osteotomy, and PRF was administered (Group 3, n = 10); on the other side of same patient, traditional surgery was performed (Group 4, n = 10). Parameters assessed at baseline for each patient included pain, the number of analgesics taken, trismus, and cheek swelling. These variables were also assessed on postoperative days 1, 2, 3, and 7.
  
  
  RESULTS
  Statistical analysis revealed a significant reduction in postoperative pain (sum of 1(st), 2(nd), 3(rd) and 7(th) days) and trismus (on postoperative day 1) in group 2 (traditional surgery + PRF group), and in postoperative pain, the number of analgesics taken (sum of 1(st), 2(nd),3(rd) and 7(th) days) and trismus (on postoperative day 1) in group 3 (piezosurgery + PRF group) compared to groups 1 and 4 (traditional surgery groups), (p ≤ 0.05). However, swelling on postoperative days 1, 3, and 7 did not differ among the groups (p > 0.05). Only difference was on second day between groups 1-4 and 2-4 (p ≤ 0.05).
  
  
  CONCLUSIONS
  The results of our study have shown that the use of PRF with traditional surgery and PRF combined with piezosurgery significantly reduced pain during the postoperative period. In addition, PRF in combination with piezosurgery significantly decreased the number of analgesics taken. Both operations also significantly decreased trismus 24 h after the surgery. As a result of this study, PRF and combination use of PRF and piezosurgery have positive effects in reducing postoperative outcomes after impacted third molar surgery.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Near East University Faculty of Dentistry, Nicosia, Cyprus. lokmanonur@gmail.com.
authors.forename: Lokman Onur
authors.initials: LO
authors.lastname: Uyanık
authors.affiliation: Department of Oral and Maxillofacial Surgery, Near East University Faculty of Dentistry, Nicosia, Cyprus. kani_blgnylr@hotmail.com.
authors.forename: Kani
authors.initials: K
authors.lastname: Bilginaylar
authors.affiliation: Department of Biostatistics, Near East University Faculty of Medicine, Nicosia, Cyprus. ietikan@gmail.com.
authors.forename: İlker
authors.initials: İ
authors.lastname: Etikan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000473:pathology / Q000601:surgery*; D061646:Operative Time; D010147:Pain Measurement; D010149:Postoperative Pain / Q000503:physiopathology*; D059745:Piezosurgery / Q000379:methods*; D053657:Platelet-Rich Plasma; D011182:Postoperative Care / Q000379:methods; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies; D011859:Radiography; D014081:Tooth Extraction / Q000379:methods*; D014095:Tooth, Impacted / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult