title: Stable neuropsychiatric status in multiple sclerosis: a 3-year study.
abstract: Personality changes and neuropsychiatric symptoms are found in multiple sclerosis (MS), but no study has evaluated decline compared to healthy controls. This study assessed personality traits and neuropsychiatric symptoms over 3 years using the NEO Five Factor Inventory and the Neuropsychiatric Inventory. Additional metrics evaluated ambulation, manual dexterity and cognitive function. Contrary to hypothesis, patients showed no significant change in personality or neuropsychiatric status relative to controls. Patients were impaired in motor and cognitive function at baseline and follow-up, but showed only slowing in ambulation over time. The findings indicate that neuropsychiatric status is stable in MS over 3 years.
authors.affiliation: Department of Neurology, University at Buffalo, USA.
authors.forename: Shumita
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Neurology, University at Buffalo, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rodgers
authors.affiliation: Department of Neurology, University at Buffalo, USA.
authors.forename: Allison S
authors.initials: AS
authors.lastname: Drake
authors.affiliation: Department of Neurology, University at Buffalo, USA/Buffalo Neuroimaging Analysis Center, University at Buffalo, USA/MR Imaging Clinical Translational Research Center, University at Buffalo, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Zivadinov
authors.affiliation: Department of Neurology, University at Buffalo, USA.
authors.forename: Bianca
authors.initials: B
authors.lastname: Weinstock-Guttman
authors.affiliation: Department of Neurology, University at Buffalo, USA benedict@buffalo.edu.
authors.forename: Ralph H B
authors.initials: RH
authors.lastname: Benedict
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003071:Cognition; D004185:Disability Evaluation; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D051346:Mobility Limitation; D009043:Motor Activity; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D009483:Neuropsychological Tests; D010551:Personality; D010552:Personality Assessment; D011795:Surveys and Questionnaires; D013997:Time Factors
keywords: Multiple sclerosis; cognitive decline; personality