title: Contradictory Relationships between Cancer and Normal Cells and Implications for Anti-cancer Therapy.
abstract: Cancer treatment remains a serious problem worldwide. Analysis of the relationship between cancer cells and normal cells reveals that these two share characteristics in contradiction, thus could be analyzed by using contradictory principles. Under the theory of contradictory principles, induction of a dormant state or reversal of cancer cells is an important treatment strategy beyond traditional cytotoxic therapy. Normal cells are also the targets and under the influence of anti-cancer treatments and should be considered during therapy. Findings based on crosstalk between these two cell types may offer opportunities for the development of new biomarkers and therapies.
authors.affiliation: Institute of Basic Medical Science and Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Xi'an Medical University, Xi'an, China E-mail : gouxingchun@189.cn.
authors.forename: Xing-Chun
authors.initials: XC
authors.lastname: Gou
authors.forename: Derek
authors.initials: D
authors.lastname: Kong
authors.forename: Xu
authors.initials: X
authors.lastname: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D000970:Antineoplastic Agents