title: The P275A Polymorphism in the Macrophage Scavenger Receptor 1 Gene and Prostate Cancer Risk: a Meta-Analysis.
abstract: BACKGROUND
  Published data regarding associations between the P275A polymorphism in the macrophage scavenger receptor 1 (MSR1) gene and prostate cancer (PCa) risk are inconclusive. The aim of this study was to comprehensively evaluate the genetic risk of P275A polymorphism in MSR1 gene for PCa.
  
  
  METHODS
  A systematic literature search was carried out in Pubmed, Medline (Ovid), Embase, CBM, CNKI, Weipu, and Wanfang databases, covering all available publications (last search was performed on Apr 27, 2015). Statistical analysis was performed using Revman 5.2 and STATA 10.1 software.
  
  
  RESULTS
  A total of 5,017 cases and 4,869 controls in 12 case-control studies were included in this meta-analysis. When all groups were pooled, there was no evidence that the P275A polymorphism had a significant association with PCa under dominant (OR=0.93, 95%CI=0.81-1.06, and p=0.28), co-dominant (homogeneous OR=0.97, 95%CI=0.56-1.68, and p=0.92; heterogeneous OR=0.93, 95%CI=0.74-1.15, and p=0.49), recessive (OR=1.10, 95%CI=0.65-1.87, and p=0.73), over-dominant (OR=0.93, 95%CI=0.75-1.15, and p=0.50), and allelic (OR=0.95, 95%CI=0.77-1.16, and p=0.61) genetic models. For stratified analyses by ethnicity and study design, no significant associations were found in the white race, the yellow race, the black race and mixed ethnicity, and the population-based case-control (PCC) and hospital-based case-control (HCC) studies under all genetic models.
  
  
  CONCLUSIONS
  Based on our meta-analysis, the P275A polymorphism in the MSR1 gene is unlikely to be a risk factor for PCa.
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan Province, China E-mail : huangying68@163.com.
authors.forename: Qiao-Xia
authors.initials: QX
authors.lastname: Zhou
authors.forename: Jian-Qiu
authors.initials: JQ
authors.lastname: Tang
authors.forename: Fen
authors.initials: F
authors.lastname: Zhao
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Wei
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D051117:Scavenger Receptors, Class A / Q000235:genetics*
chemical_list: C495139:MSR1 protein, human; D051117:Scavenger Receptors, Class A