title: Chemical and Physical Characteristics of Doxorubicin Hydrochloride Drug-Doped Salmon DNA Thin Films.
abstract: Double-stranded salmon DNA (SDNA) was doped with doxorubicin hydrochloride drug molecules (DOX) to determine the binding between DOX and SDNA, and DOX optimum doping concentration in SDNA. SDNA thin films were prepared with various concentrations of DOX by drop-casting on oxygen plasma treated glass and quartz substrates. Fourier transform infrared (FTIR) spectroscopy was employed to investigate the binding sites for DOX in SDNA, and electrical and photoluminescence (PL) analyses were used to determine the optimum doping concentration of DOX. The FTIR spectra showed that up to a concentration of 30 μM of DOX, there was a tendency for binding with a periodic orientation via intercalation between nucleosides. The current and PL intensity increased as the DOX concentration increased up to 30 μM, and then as the concentration of DOX further increased, we observed a decrease in current as well as PL quenching. Finally, the optical band gap and second band onset of the transmittance spectra were analyzed to further verify the DOX binding and optimum doping concentration into SDNA thin films as a function of the DOX concentration.
authors.affiliation: 1] Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 440-746, Korea [2] Department of Physics, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Bramaramba
authors.initials: B
authors.lastname: Gnapareddy
authors.affiliation: 1] Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 440-746, Korea [2] Department of Physics, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Sreekantha Reddy
authors.initials: SR
authors.lastname: Dugasani
authors.affiliation: Department of Physics, Yonsei University, Seoul 120-749, Korea.
authors.forename: Taewoo
authors.initials: T
authors.lastname: Ha
authors.affiliation: Department of Physics, Yonsei University, Seoul 120-749, Korea.
authors.forename: Bjorn
authors.initials: B
authors.lastname: Paulson
authors.affiliation: 1] Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 440-746, Korea [2] School of Mechanical Engineering, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Taehyun
authors.initials: T
authors.lastname: Hwang
authors.affiliation: 1] Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 440-746, Korea [2] School of Mechanical Engineering, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Taesung
authors.initials: T
authors.lastname: Kim
authors.affiliation: Department of Physics, Yonsei University, Seoul 120-749, Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Physics, Yonsei University, Seoul 120-749, Korea.
authors.forename: Kyunghwan
authors.initials: K
authors.lastname: Oh
authors.affiliation: 1] Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 440-746, Korea [2] Department of Physics, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Sung Ha
authors.initials: SH
authors.lastname: Park
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers; D008163:Luminescent Measurements; D012474:Salmon / Q000235:genetics*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004337:Drug Carriers; D004317:Doxorubicin; D004247:DNA