title: Survival in Subcortical Vascular Dementia: Predictors and Comparison to Probable Alzheimer's Disease in a Tertiary Memory Clinic Population.
abstract: BACKGROUND
  Subcortical vascular dementia (SVaD) is one of the most common dementias, after Alzheimer's disease (AD) dementia. Few survival analyses in SVaD patients have been reported.
  
  
  METHODS
  The dates and causes of death of 146 SVaD and 725 AD patients were included. We used the Cox proportional hazards model to compare survival between SVaD and AD patients and to explore possible factors related to survival of SVaD patients.
  
  
  RESULTS
  The median survival time after the onset of SVaD (109 months) was shorter than that recorded for AD (152 months). The most common cause of death in SVaD was stroke (47.1%). Factors associated with shorter survival in SVaD were late onset, male sex, worse baseline cognition, absence of hypertension and a family history of stroke.
  
  
  CONCLUSIONS
  Stroke prevention may be important in SVaD treatment because 47.1% of SVaD patients died of stroke. A family history of stroke and absence of hypertension were associated with a shorter survival in SVaD, suggesting the existence of genetic or unknown risk factors.
authors.affiliation: Department of Neurology, Dementia Center, Stroke Center, Ilsan Hospital, National Health Insurance Service, Goyang, South Korea.
authors.forename: Jong Hun
authors.initials: JH
authors.lastname: Kim
authors.forename: Seok Min
authors.initials: SM
authors.lastname: Go
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
authors.forename: Suk Hui
authors.initials: SH
authors.lastname: Kim
authors.forename: Juhee
authors.initials: J
authors.lastname: Chin
authors.forename: So Young
authors.initials: SY
authors.lastname: Moon
authors.forename: Hyunsun
authors.initials: H
authors.lastname: Lim
authors.forename: Hae Kwan
authors.initials: HK
authors.lastname: Cheong
authors.forename: Sun Ah
authors.initials: SA
authors.lastname: Choi
authors.forename: Jun Hong
authors.initials: JH
authors.lastname: Lee
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000401:mortality*; D015140:Dementia, Vascular / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D020521:Stroke / Q000517:prevention & control; D016019:Survival Analysis