title: Vocal fold mobility as the main prognostic factor of treatment outcomes and survival in stage II squamous cell carcinomas of the glottic larynx.
abstract: OBJECTIVE
  This study aimed to assess the influence of supra- and subglottic extensions and vocal fold mobility on outcome in a large monocentric cohort of 148 patients treated for tumour-node-metastasis stage T2N0 glottic carcinomas.
  
  
  METHODS
  In all, 107 glottic carcinoma patients had normal vocal fold mobility (T2aN0), and 41 had impaired vocal fold mobility (T2bN0). Treatment decisions were made by a multidisciplinary team.
  
  
  RESULTS
  Vocal fold mobility was associated with overall survival, disease-free survival, local control, larynx preservation and laryngectomy-free survival. For patients with T2a lesions, local control, laryngectomy-free survival and disease-free survival improved after surgery but overall survival did not. For patients with T2b lesions, local control, laryngectomy-free survival, disease-free survival and overall survival were all higher after surgery than after radiotherapy.
  
  
  CONCLUSIONS
  This study highlights for the first time the importance of vocal fold mobility in treatment outcomes and is the first to assess its influence on survival. Updated tumour-node-metastasis classifications should consider the distinction between T2a and T2b lesions.
authors.affiliation: Department of Head and Neck Oncology,Institut Gustave Roussy,Villejuif,France.
authors.forename: P
authors.initials: P
authors.lastname: Gorphe
authors.affiliation: Department of Radiotherapy,Institut Gustave Roussy,Villejuif,France.
authors.forename: P
authors.initials: P
authors.lastname: Blanchard
authors.affiliation: Department of Head and Neck Oncology,Institut Gustave Roussy,Villejuif,France.
authors.forename: I
authors.initials: I
authors.lastname: Breuskin
authors.affiliation: Department of Head and Neck Oncology,Institut Gustave Roussy,Villejuif,France.
authors.forename: S
authors.initials: S
authors.lastname: Temam
authors.affiliation: Department of Radiotherapy,Institut Gustave Roussy,Villejuif,France.
authors.forename: Y
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Department of Radiotherapy,Institut Gustave Roussy,Villejuif,France.
authors.forename: F
authors.initials: F
authors.lastname: Janot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D059248:Chemoradiotherapy; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D007825:Laryngectomy; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009361:Neoplasm Invasiveness; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D014826:Vocal Cord Paralysis / Q000209:etiology* / Q000401:mortality*; D014827:Vocal Cords / Q000473:pathology
keywords: Glottis; Laryngeal Neoplasms; Squamous Cell Carcinoma; Treatment Outcome; Vocal Cords