title: The genetic mechanisms of primary angle closure glaucoma.
abstract: Primary Angle Closure Glaucoma (PACG) is one of the most common types of glaucoma affecting over 15 million individuals worldwide. Family history and ethnicity are strongly associated with the development of the disease, suggesting that one or more genetic factors contribute to PACG. Although strictly heritable disease-causing mutations have not been identified, a number of recent association studies have pointed out genetic factors that appear to contribute to an individual's risk to develop PACG. In addition, genetic factors have been identified that modify PACG endophenotypes for example, axial length. Herein we review the current literature on this important topic.
authors.affiliation: Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA.
authors.forename: D F
authors.initials: DF
authors.lastname: Ahram
authors.affiliation: Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Alward
authors.affiliation: Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Kuehn
mesh_terms: D001369:Axons / Q000473:pathology; D005136:Eye Proteins / Q000235:genetics; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015812:Glaucoma, Angle-Closure / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007429:Intraocular Pressure / Q000235:genetics; D012165:Retinal Ganglion Cells / Q000473:pathology; D012307:Risk Factors
chemical_list: D005136:Eye Proteins