title: Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe.
abstract: A highly specific fluorescent probe (OC9) was discovered exhibiting tubulin-specific affinity fluorescence, which allowed selective labeling of cellular tubulin in microtubules. Moreover, distinct tubulin dynamics in various cellular bio-settings such as drug resistant or epithelial-mesenchymal transition (EMT) cancer cells were directly observed for the first time via OC9 staining.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, GuangZhou 510006, China. phsbxzh@mail.sysu.edu.cn.
authors.forename: Cuige
authors.initials: C
authors.lastname: Zhu
authors.forename: Yinglin
authors.initials: Y
authors.lastname: Zuo
authors.forename: Baoxia
authors.initials: B
authors.lastname: Liang
authors.forename: Hong
authors.initials: H
authors.lastname: Yue
authors.forename: Xin
authors.initials: X
authors.lastname: Yue
authors.forename: Gesi
authors.initials: G
authors.lastname: Wen
authors.forename: Ruimin
authors.initials: R
authors.lastname: Wang
authors.forename: Junmin
authors.initials: J
authors.lastname: Quan
authors.forename: Jun
authors.initials: J
authors.lastname: Du
authors.forename: Xianzhang
authors.initials: X
authors.lastname: Bu
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry*; D019008:Drug Resistance, Neoplasm; D058750:Epithelial-Mesenchymal Transition; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D008856:Microscopy, Fluorescence; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism; D014404:Tubulin / Q000737:chemistry* / Q000378:metabolism
chemical_list: C000607804:3-(4-(dimethylamino)phenyl)-1-(4'-fluoro(1,1'-biphenyl)-2-yl)prop-2-en-1-one; D000814:Aniline Compounds; D047188:Chalcones; D005456:Fluorescent Dyes; D014404:Tubulin