title: IL-2/IL-2 antibody immune complex regulates HSV-induced inflammation through induction of IL-2 receptor alpha, beta, and gamma in a mouse model.
abstract: The differences of serum IL-2 levels were not consistent between Behçet's Disease (BD) patients and healthy controls, however, the correlation of interleukin-2 receptor (IL-2R) and BD has not been investigated. IL-2R is composed of three subunits; alpha, beta, and gamma. The expression frequencies of IL-2R subunits were analyzed in the peripheral blood mononuclear cells, spleens, and lymph node (LN) cells. The expression of IL-2R subunits was different between BD mice and controls. IL-2R beta expressing cell frequencies were also different between BD patients and healthy controls. The IL-2/anti-mIL-2 antibody complex administration regulated the IL-2R subunits in mice. The change of expression in IL-2R was accompanied by the increase of CD8+CD44+ memory T cells, CD3-NK1.1+CD11b+CD27+ natural killer cells, and improvement of symptoms. In this study, we elucidated the role of IL-2R subunits on BD, a finding that can be connected to therapeutic strategy for patients based on the results from the treatment of BD mice.
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Bunsoon
authors.initials: B
authors.lastname: Choi
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Ju A
authors.initials: JA
authors.lastname: Shim
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Eun-So
authors.initials: ES
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Do Young
authors.initials: DY
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Dongsik
authors.initials: D
authors.lastname: Bang
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea; Department of Biomedical Sciences, Graduate Program of Molecular Medicine, Ajou University, Suwon, Republic of Korea. Electronic address: sohnsh@ajou.ac.kr.
authors.forename: Seonghyang
authors.initials: S
authors.lastname: Sohn
mesh_terms: D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001528:Behcet Syndrome / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism* / Q000821:virology; D016022:Case-Control Studies; D004195:Disease Models, Animal; D000068800:Etanercept / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D016130:Immunophenotyping; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D053631:Interleukin Receptor Common gamma Subunit / Q000378:metabolism; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology*; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D053646:Interleukin-2 Receptor beta Subunit / Q000037:antagonists & inhibitors / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D018139:Simplexvirus; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D007166:Immunosuppressive Agents; D053631:Interleukin Receptor Common gamma Subunit; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D053646:Interleukin-2 Receptor beta Subunit; D015375:Receptors, Interleukin-2; D000068800:Etanercept
keywords: Behçet’s disease; HSV; IL-2/IL-2 antibody immune complex; IL-2Rαβγ; Mouse model