title: Two new sesquiterpene lactones from the fruits of Illicium jiadifengpi.
abstract: Two new seco-prezizaane-type sesquiterpenes, 3,4-dehydroneomajucin (1) and 1,2,3,4-tetradehydroneomajucin (2), were isolated from the fruits of Illicium jiadifengpi. The structure of these compounds was determined using 1D and 2D NMR and ESI-MS. The isolates were evaluated for their anti-hepatitis B virus activities on the Hep G2.2.15 cell line. The inhibitory rates of compounds 1 and 2 on the HBeAg and HBsAg expression were 30.08 ± 3.09% and 11.43 ± 1.92% at a concentrations of 68.00 μM and 7.88 ± 1.21% and 16.96 ± 4.24% at a concentration of 68.50 μM, respectively.
authors.affiliation: a School of Pharmaceutical Science, Zhengzhou University , Ke Xue Da Dao 100, Zhengzhou 450001 , People's Republic of China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: a School of Pharmaceutical Science, Zhengzhou University , Ke Xue Da Dao 100, Zhengzhou 450001 , People's Republic of China.
authors.forename: Feiyan
authors.initials: F
authors.lastname: Liu
authors.affiliation: b School of Pharmacy, Guiyang Medical University , Guiyang 550004 , People's Republic of China.
authors.forename: Nenling
authors.initials: N
authors.lastname: Zhang
authors.affiliation: a School of Pharmaceutical Science, Zhengzhou University , Ke Xue Da Dao 100, Zhengzhou 450001 , People's Republic of China.|c Henan Key Laboratory for Pharmacology of Liver Disease, Academy of Medical and Pharmaceutical Science, Zhengzhou University , 40 Daxue Road, Zhengzhou 450052 , People's Republic of China.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a School of Pharmaceutical Science, Zhengzhou University , Ke Xue Da Dao 100, Zhengzhou 450001 , People's Republic of China.
authors.forename: Lijia
authors.initials: L
authors.lastname: Yang
authors.affiliation: a School of Pharmaceutical Science, Zhengzhou University , Ke Xue Da Dao 100, Zhengzhou 450001 , People's Republic of China.
authors.forename: Yuefeng
authors.initials: Y
authors.lastname: Bi
authors.affiliation: a School of Pharmaceutical Science, Zhengzhou University , Ke Xue Da Dao 100, Zhengzhou 450001 , People's Republic of China.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: d School of Pharmaceutical Science, Henan University of Traditional Chinese Medicine , Zhengzhou 450008 , People's Republic of China.
authors.forename: Mengqi
authors.initials: M
authors.lastname: Liu
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005638:Fruit / Q000737:chemistry; D056945:Hep G2 Cells / Q000187:drug effects / Q000821:virology; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D029523:Illicium / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C000609649:1,2,3,4-tetradehydroneomajucin; C000609648:3,4-dehydroneomajucin; D000998:Antiviral Agents; D007783:Lactones; D012717:Sesquiterpenes
keywords: Illicium jiadifengpi; anti-HBV activity; sesquiterpene lactones