title: Higher Order Aberrations and Visual Outcomes in Wavefront-Optimized Sub-Bowman Keratomileusis: Flap Creation Using Femtosecond Laser Versus Mechanical Microkeratome.
abstract: OBJECTIVE
  The aim of this study was to compare the outcomes of wavefront-optimized sub-Bowman keratomileusis (SBK) performed using the 150 KHz IntraLase femtosecond (IFS) laser (Abbot Medical Optics) with those using the Moria Evo 3 One Use-Plus SBK mechanical microkeratome (Moria SA).
  
  
  METHODS
  A prospective comparative clinical trial.
  
  
  METHODS
  Fifty patients had bilateral wavefront-optimized SBK performed for myopia or myopic astigmatism. In 25 patients, the flap was created with the 150 KHz IFS laser (group 1) and in the other 25 with the Moria One Use-Plus SBK mechanical microkeratome (group 2). All other treatment parameters were the same. Results were reported for 1 eye per patient in each group (ie, 25 eyes in each group).
  
  
  RESULTS
  Efficacy, refractive stability, predictability, and safety profiles were comparable between the 2 groups. Although higher order aberrations (HOAs) increased significantly in both groups after laser in situ keratomileusis, intergroup comparison revealed that group 1 was associated with a significantly higher induction of both total HOAs [mean root mean square (RMS), 0.63 ± 0.20 in group 1 vs 0.52 ± 0.14 in group 2; P = 0.031] and spherical aberrations (RMS, 0.37 ± 0.17 in group 1 vs 0.22 ± 0.09 in group 2; P < 0.001) as compared with group 2.
  
  
  CONCLUSIONS
  Flaps created using the Moria Evo 3 One Use-Plus SBK mechanical microkeratome were associated with significantly lower induction of total HOAs and spherical aberrations as compared with 150 KHz IFS flaps at the end of 3 months follow-up.
authors.affiliation: From the Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Chintan
authors.initials: C
authors.lastname: Malhotra
authors.forename: Arun K
authors.initials: AK
authors.lastname: Jain
authors.forename: Jayashree
authors.initials: J
authors.lastname: Veluswami
authors.forename: Jagat
authors.initials: J
authors.lastname: Ram
authors.forename: Raghav
authors.initials: R
authors.lastname: Gupta
authors.forename: Pawan
authors.initials: P
authors.lastname: Kumar
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000601:surgery*; D003315:Cornea / Q000601:surgery; D003319:Corneal Stroma / Q000601:surgery; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use; D008297:Male; D009216:Myopia / Q000601:surgery*; D011446:Prospective Studies; D012029:Refraction, Ocular; D013524:Surgical Flaps; D014792:Visual Acuity; D055815:Young Adult