title: Soluble CD163 is increased in patients with acute pancreatitis independent of disease severity.
abstract: Macrophages are crucially involved in the pathophysiology of acute pancreatitis. Soluble CD163 (sCD163) is specifically released from macrophages and systemic levels are increased in inflammatory diseases. Here, sCD163 was measured in serum of 50 patients with acute pancreatitis to find out possible associations with disease activity. Admission levels of systemic sCD163 were nearly three-fold higher in patients with acute pancreatitis compared to controls. In patients sCD163 did not correlate with C-reactive protein and leukocyte count as established markers of inflammation. Levels were not associated with disease severity assessed by the Schroeder score, Balthazar score, Acute Physiology, Age, and Chronic Health Evaluation (Apache) II score and peripancreatic necrosis score. Soluble CD163 was not related to complications of acute pancreatitis. These data show that serum sCD163 is increased in acute pancreatitis indicating activation of macrophages but is not associated with disease severity and outcome.
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Karrasch
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Brünnler
authors.affiliation: Department of Radiology, Regensburg University Hospital, Regensburg, Germany.
authors.forename: Okka W
authors.initials: OW
authors.lastname: Hamer
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Schmid
authors.affiliation: Department of Radiology, Regensburg University Hospital, Regensburg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Voelk
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany; Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Hans
authors.initials: H
authors.lastname: Herfarth
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany. Electronic address: christa.buechler@klinik.uni-regensburg.de.
authors.forename: Christa
authors.initials: C
authors.lastname: Buechler
mesh_terms: D018806:APACHE; D000208:Acute Disease; D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000378:metabolism* / Q000473:pathology*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012720:Severity of Illness Index; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface
keywords: Acute pancreatitis; Macrophage; Peripancreatic necrosis