title: Probiotics and immunity: provisional role for personalized diets and disease prevention.
abstract: There is great interest in the interaction between diet and immune system and concomitantly in the potential of probiotic bacteria, especially given recent advances in understanding of gut microbiota effects on health in the context of microbiome research. Following our recent study on bacterial wall elasticity as a predictive measure of phagocytic cellular reactions and related outcomes, a question was raised regarding the scope of the application of these findings in various medical conditions in the context of predictive, preventive, and personalized medicine (PPPM). This summarizing review of the data describes the contributions, both observed and potential, of probiotics to the gut-brain axis and various medical conditions, including immune and atopic states, metabolic and inflammatory diseases-including liver disease and diabetes mellitus-cancer, and more. It also suggests novel insights for a number of beneficial applications of probiotics and advances in development of novel probiotic-based treatments and personalized diets, as well as application of sophisticated imaging techniques and nanobiotechnologies that can be adopted in the near future by innovative medical experts, warranting further research and practical translation.
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv, 03680 Ukraine ; Clinical Hospital "Pheophania" of State Affairs Department, Zabolotny Str., 21, Kyiv, 03680 Ukraine.
authors.forename: Rostyslav V
authors.initials: RV
authors.lastname: Bubnov
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv, 03680 Ukraine ; LCL "Diaprof", Svitlycky Str., 35, Kyiv, 04123 Ukraine.
authors.forename: Mykola Ya
authors.initials: MY
authors.lastname: Spivak
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv, 03680 Ukraine.
authors.forename: Liudmyla M
authors.initials: LM
authors.lastname: Lazarenko
authors.affiliation: Cassovia Life Sciences, Palárikova 4, 04011 Košice, Slovak Republiс ; Institute of Experimental Medicine, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04011 Košice, Slovak Republiс
authors.forename: Alojz
authors.initials: A
authors.lastname: Bomba
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv, 03680 Ukraine ; Cassovia Life Sciences, Palárikova 4, 04011 Košice, Slovak Republiс
authors.forename: Nadiya V
authors.initials: NV
authors.lastname: Boyko
keywords: Bifidobacterium; Cancer; Dietary biomarkers; Fecal microbiota transplantation; Gut microbiota; Gut-brain axis; Healthy diet; Immune disorders; Lactobacillus; Microbiome; Nutrition; Pattern recognition receptors; Predictive; Preventive; and personalized medicine