title: ABCB1 polymorphism and susceptibility to acute lymphoblastic leukemia: a meta analysis.
abstract: BACKGROUND
  A large body of studies has investigated the potential role of ABCB1 polymorphism in ALL susceptibility. However, the results are conflicting. The aim of the present meta-analysis was to define the effect of ABCB1 polymorphism on ALL risk.
  
  
  METHODS
  We identified 8 eligible studies involving 1,308 cases and 1,427 controls through searching PubMed and Enbase databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the strength of the association with both fixed effects and random effect models.
  
  
  RESULTS
  We found ABCB1 polymorphism was associated with an increased risk of ALL under the homozygote genotypes (TT vs. CC: OR, 1.29, 95% CI, 1.08-1.54), the recessive model (TT vs. CT + CC: OR, 1.47, 95% CI, 1.02-2.13) and the allele model (T vs. C: OR, 1.14, 95% CI, 1.04-1.25). Similar results were indicated in Asian populations (TT vs. CC: OR, 1.79, 95% CI, 1.32-2.43; TT vs. CT + CC: OR, 2.55, 95% CI, 1.47-4.43; T vs. C: OR, 1.38, 95% CI, 1.18-1.62), but not in Caucasian populations.
  
  
  CONCLUSIONS
  These findings indicate that ABCB1 polymorphism may play a critical role in the development of ALL in Asians.
authors.affiliation: Gynaecology Ward-1, Linyi City People's Hospital Linyi 276000, Shandong Province, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Gynaecology Ward-1, Linyi City People's Hospital Linyi 276000, Shandong Province, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Gastrointestinal Surgery, Linyi City People's Hospital Linyi276000, Shandong Province, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Li
keywords: ABCB1; ALL; polymorphism