title: Biocontrol evaluation of extracts and a major component, clusianone, from Clusia fluminensis Planch. & Triana against Aedes aegypti.
abstract: Studies evaluated the effects of hexanic extracts from the fruits and flowers of Clusia fluminensis and the main component of the flower extract, a purified benzophenone (clusianone), against Aedes aegypti. The treatment of larvae with the crude fruit or flower extracts from C. fluminensis did not affect the survival ofAe. aegypti (50 mg/L), however, the flower extracts significantly delayed development of Ae. aegypti. In contrast, the clusianone (50 mg/L) isolate from the flower extract, representing 54.85% of this sample composition, showed a highly significant inhibition of survival, killing 93.3% of the larvae and completely blocking development of Ae. aegypti. The results showed, for the first time, high activity of clusianone against Ae. aegypti that both killed and inhibited mosquito development. Therefore, clusianone has potential for development as a biopesticide for controlling insect vectors of tropical diseases. Future work will elucidate the mode of action of clusianone isolated from C. fluminensis.
authors.affiliation: Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Anholeti
authors.affiliation: Laboratório de Biologia de Insetos, Universidade Federal Fluminense, Niterói, RJ, BR.
authors.forename: Rodrigo C
authors.initials: RC
authors.lastname: Duprat
authors.affiliation: Laboratório de Química de Produtos Naturais, Farmanguinhos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, BR.
authors.forename: Maria R
authors.initials: MR
authors.lastname: Figueiredo
authors.affiliation: nstituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: Maria Ac
authors.initials: MA
authors.lastname: Kaplan
authors.affiliation: Departamento de Ciências, Faculdade de Formação de Professores, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: Marcelo Guerra
authors.initials: MG
authors.lastname: Santos
authors.affiliation: Laboratório de Biologia de Insetos, Universidade Federal Fluminense, Niterói, RJ, BR.
authors.forename: Marcelo S
authors.initials: MS
authors.lastname: Gonzalez
authors.affiliation: Laboratório de Biologia de Insetos, Universidade Federal Fluminense, Niterói, RJ, BR.
authors.forename: Norman A
authors.initials: NA
authors.lastname: Ratcliffe
authors.affiliation: Laboratório de Biologia de Insetos, Universidade Federal Fluminense, Niterói, RJ, BR.
authors.forename: Denise
authors.initials: D
authors.lastname: Feder
authors.affiliation: Laboratório de Botânica Estrutural e Funcional, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, BR.
authors.forename: Selma R
authors.initials: SR
authors.lastname: Paiva
authors.affiliation: Laboratório de Biologia de Insetos, Universidade Federal Fluminense, Niterói, RJ, BR.
authors.forename: Cicero B
authors.initials: CB
authors.lastname: Mello
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D031251:Clusia / Q000737:chemistry*; D007303:Insect Vectors / Q000187:drug effects*; D007814:Larva / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D010936:Plant Extracts