title: [Myxoinflammatory fibroblastic sarcoma: clinicopathologic and immunohistochemical analysis].
abstract: OBJECTIVE
  To study the specific features of myxoinflammatory fibroblastic sarcoma (MIFS), by providing clinicopathologic and immunohistochemical evaluations of neoplasms and the biological behavior of these tumors and analyzing their recurrent forms.
  
  
  METHODS
  Ten cases of MIFS were examined with emphasis on its clinicopathological and immunohistochemical features.
  
  
  RESULTS
  In 9 cases, the tumor involved the acral part of the extremities; in one case, it was located in the superficial tissues of the thigh. All neoplasms had a classical histological pattern of MIFS. Four cases developed local recurrences most likely due to the inadequate volume of surgical intervention. Three tumors held its original histological form, but one showed marked histologic progression. Immunohistochemically, all the tumors expressed vimentin. Some cases exhibited a positive reaction with CD68, factor XIIIa, and podoplanin.
  
  
  CONCLUSIONS
  Despite altered morphological patterns, the immunoprofile of recurrent MIFS was retained. A tendency for recurrence requires that the resection margins should be meticulously investigated to exclude residual tumor.
authors.affiliation: N.N. Petrov Research Institute of Oncology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg.
authors.forename: K V
authors.initials: KV
authors.lastname: Shelekhova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D005169:Factor VIII / Q000378:metabolism*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology; D000097382:CD68 Molecule; D000098853:Podoplanin
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D005169:Factor VIII; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C117468:PDPN protein, human; D000098853:Podoplanin; C078147:F8 protein, human