title: Highest risk of symptomatic venous thromboembolic events after radical cystectomy occurs in patients with obesity or nonurothelial cancers.
abstract: BACKGROUND
  Venous thromboembolism (VTE) is a common cause of postoperative morbidity and mortality in cystectomy patients.
  
  
  OBJECTIVE
  The aim of this study is to identify variables associated with risk of developing deep venous thrombosis (DVT) or pulmonary embolism (PE) within 90 days after radical cystectomy (RC).
  
  
  METHODS
  Retrospective chart review of patients undergoing RC from 2004 to 2011 at the University of Wisconsin.
  
  
  METHODS
  Clinical variables collected for all RC patients. All patients received mechanical prophylaxis, and routine heparin prophylaxis began in 2010.
  
  
  METHODS
  Univariate and multivariate analyses were used to evaluate VTE association with known risk factors.
  
  
  RESULTS
  A total of 241 patients were identified with median age of 67.1 (interquartile range: 57.8-74.3) years. Body mass index (BMI) was ≥30 in 36.8% of patients. Median blood loss was 950 (600-1500) mL and 157/241 (65.2%) patients received a blood transfusion.
  
  
  CONCLUSIONS
  Patients with BMI ≥30 or nonurothelial cancer are at highest risk for postoperative VTE and should be considered for extended heparin prophylaxis.
authors.affiliation: Department of Urology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Potretzke
authors.affiliation: Department of Urology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Kelvin S
authors.initials: KS
authors.lastname: Wong
authors.affiliation: Department of Urology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Shi
authors.affiliation: Department of Urology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: William
authors.initials: W
authors.lastname: Christensen
authors.affiliation: Department of Urology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Tracy M
authors.initials: TM
authors.lastname: Downs
authors.affiliation: Department of Urology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: E Jason
authors.initials: EJ
authors.lastname: Abel
keywords: Cystectomy; deep vein thrombosis; nonurothelial; obesity; thromboembolism