title: Neurosubstrates and mechanisms underlying the extinction of associative motor memory.
abstract: Eyeblink conditioning is one of the most commonly used model systems to investigate the neural mechanisms underlying associative motor learning. It is well established that the acquisition and retention of conditioned eyeblink responses (CRs) involve neural plasticity in both the cerebellar cortex and deep cerebellar nuclei (DCN). Nevertheless, how learned CRs are extinguished remains relatively unclear. It has been suggested that extinguished CRs can recur spontaneously, can reappear by exposure to certain stimuli, and can be reacquired in fewer training trials than originally needed, indicating that associative motor memory is not merely erased by extinction training. Instead, the motor memory is preserved to some degree. Herein, we reviewed recent experimental findings demonstrating that the cerebellum subserves the preservation of learned CRs. In addition, several lines of evidence have suggested that forebrain structures (i.e., the medial prefrontal cortex and hippocampus) are involved in the CR extinction. We proposed possible mechanisms related to how preserved motor memory in the cerebellum is inhibited by the forebrain structures via the amygdalar complex.
authors.affiliation: Department of Physiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, PR China; Battalion 8 of Cadet Brigade, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Physiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, PR China; Battalion 11 of Cadet Brigade, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Zhang
authors.affiliation: Department of Physiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China. Electronic address: xiongyandoctor@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Department of Physiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, PR China. Electronic address: bohu@tmmu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
mesh_terms: D000679:Amygdala / Q000502:physiology; D000818:Animals; D001245:Association Learning / Q000502:physiology; D001767:Blinking; D002525:Cerebellar Cortex / Q000502:physiology*; D002529:Cerebellar Nuclei / Q000502:physiology*; D003215:Conditioning, Eyelid / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity; D017397:Prefrontal Cortex / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology*
keywords: Amygdala; Cerebellum; Eyeblink conditioning; Medial prefrontal cortex