title: Evaluation of some pharmacological activities of Budmunchiamine - A isolated from Albizia amara.
abstract: The present investigations were aimed to evaluate the antimicrobial and antioxidant efficacies of budmunchiamine-A (BUA) of Albizia amara . The activity-guided isolation leaded to isolate the bioactive compound budmunchiamine-A from alkaloid extract of A. amara . The budmunchiamine-A showed significant broad-spectrum antimicrobial activity with zone of inhibition (ZOI), minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values varied from 7.3 to 24.5 mm, 0.95 to 62.5 μg/mL, and 1.9 to 250 μg/mL, respectively. The budmunchiamine-A exhibited moderate antioxidant activity with inhibitory concentration 50% (IC 50 ) value of 400 μg/mL in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and percent inhibition of β-carotene/linoleic acid was 67.8%. The results suggest the possible use of budmunchiamine-A as a molecular entity for drug development in pharmaceutical industry.
authors.affiliation: Department of Microbiology and Biotechnology, Bangalore University, Jnanabharathi, Bangalore, India.
authors.forename: Sreerangegowda
authors.initials: S
authors.lastname: Thippeswamy
authors.affiliation: Department of Microbiology and Biotechnology, Bangalore University, Jnanabharathi, Bangalore, India.
authors.forename: Devihalli Chikkaiah
authors.initials: DC
authors.lastname: Mohana
authors.affiliation: Department of Microbiology and Biotechnology, Bangalore University, Jnanabharathi, Bangalore, India.
authors.forename: Rayasandra Umesh
authors.initials: RU
authors.lastname: Abhishek
authors.affiliation: Department of Microbiology and Biotechnology, Bangalore University, Jnanabharathi, Bangalore, India.
authors.forename: Kiragandur
authors.initials: K
authors.lastname: Manjunath
mesh_terms: D031289:Albizzia / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D010936:Plant Extracts
keywords: Albizia amara; antimicrobial activity; antioxidant activity; budmunchiamine-A