title: Proliferative and Synthetic Activity of Nerve Cells after Combined or Individual Exposure to Hypoxia and Hypercapnia.
abstract: We compared synthetic and proliferative activity of brain cells in rats exposed hypoxia, hypercapnia, or both prior to experimental focal stroke. The mean number of nucleolus organizer regions in penumbra neurons did not change after normobaric hypoxia, but increased after permissive hypercapnia or hypercapnic hypoxia. These data attest to activation of proliferative and synthetic functions in nerve cells, which plays an important role in the neuroprotective mechanisms under conditions of combined exposure to hypoxia and hypercapnia.
authors.affiliation: Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia, pfiza_asmu@mail.ru.
authors.forename: P P
authors.initials: PP
authors.lastname: Tregub
authors.forename: V P
authors.initials: VP
authors.lastname: Kulikov
authors.forename: N Yu
authors.initials: NY
authors.lastname: Rucheikin
authors.forename: E V
authors.initials: EV
authors.lastname: Belova
authors.forename: Yu G
authors.initials: YG
authors.lastname: Motin
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology; D006935:Hypercapnia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D020521:Stroke / Q000473:pathology / Q000503:physiopathology