title: Wide-field in vivo oral OCT imaging.
abstract: We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s allowing imaging of areas up to 225 mm(2) field-of-view in seconds. A catheter sheath and two optional catheter sheath holders have been designed to allow imaging at all locations within the oral cavity. Image quality of 2-dimensional image slices through the data can be greatly enhanced by averaging over the orthogonal dimension to reduce speckle. Initial in vivo imaging results reveal a wide-field view of features such as epithelial thickness and continuity of the basement membrane that may be useful in clinic for chair-side management of oral lesions.
authors.affiliation: Department of Integrative Oncology - Cancer Imaging Unit, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada.
authors.forename: Anthony M D
authors.initials: AM
authors.lastname: Lee
authors.affiliation: Department of Integrative Oncology - Cancer Imaging Unit, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada.
authors.forename: Lucas
authors.initials: L
authors.lastname: Cahill
authors.affiliation: Department of Integrative Oncology - Cancer Imaging Unit, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada.
authors.forename: Kelly
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Integrative Oncology - Cancer Imaging Unit, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada.
authors.forename: Calum
authors.initials: C
authors.lastname: MacAulay
authors.affiliation: Department of Integrative Oncology - Cancer Imaging Unit, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada ; Faculty of Dentistry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
authors.forename: Catherine
authors.initials: C
authors.lastname: Poh
authors.affiliation: Department of Integrative Oncology - Cancer Imaging Unit, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lane
keywords: (170.1610) Clinical applications; (170.1850) Dentistry; (170.3890) Medical optics instrumentation; (170.4500) Optical coherence tomography; (170.4580) Optical diagnostics for medicine; (170.4940) Otolaryngology