title: The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer.
abstract: Pancreatic cancer (PC) is one of the most lethal human malignancies worldwide. Here, we demonstrated that xanthohumol (XN), the most abundant prenylated chalcone isolated from hops, inhibited the growth of cultured PC cells and their subcutaneous xenograft tumors. XN treatment was found to induce cell cycle arrest and apoptosis of PC cells (PANC-1, BxPC-3) by inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3) and expression of its downstream targeted genes cyclinD1, survivin, and Bcl-xL at the messenger RNA level, which involved in regulation of apoptosis and the cell cycle. Overall, our results suggested that XN presents a promising candidate therapeutic agent against human PC and the STAT3 signaling pathway is its key molecular target.
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China. Electronic address: docjiangweiliang@163.com.
authors.forename: Weiliang
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: sunshinezsl1989@163.com.
authors.forename: Senlin
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, Shanghai Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: Xiaoling05@126.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China. Electronic address: le_voyageur@qq.com.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China. Electronic address: luzhanjun1979@126.com.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China. Electronic address: cherrychencong@163.com.
authors.forename: Congying
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China. Electronic address: nevsnev@163.com.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Ni
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China. Electronic address: doctorwanrong1970@163.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Wan
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China. Electronic address: Lijuanyang77@163.com.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Yang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D063646:Carcinogenesis / Q000187:drug effects* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002599:Chalcone / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D027582:Humulus; D051379:Mice; D008819:Mice, Nude; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D054876:Prenylation; D011427:Propiophenones / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D011427:Propiophenones; D002599:Chalcone; C104536:xanthohumol
keywords: Pancreatic cancer; STAT3 signaling; Xanthohumol