title: MP1 AND MAIA FUNDUS PERIMETRY IN HEALTHY SUBJECTS AND PATIENTS AFFECTED BY RETINAL DYSTROPHIES.
abstract: OBJECTIVE
  To compare retinal sensitivity obtained with MP1 and MAIA microperimeters in patients affected by retinal dystrophies (RD) and in healthy subjects.
  
  
  METHODS
  Thirty-six patients affected by RD and 25 healthy subjects were considered for the study. All patients and controls underwent a complete ophthalmic examination including fundus-related perimetry, performed by means of two microperimeters, the MP1 (Nidek Technologies) and the MAIA (CenterVue). Main outcome of the study was the comparison of retinal sensitivity. Such comparison was performed converting the MP1 decibel (dB) values to their MAIA equivalent dB values.
  
  
  RESULTS
  Mean retinal sensitivity in patients affected by RD was 5.68 ± 6.08 dB (mean ± SD) on MP1 (9.66 ± 10.06 dB converted to their equivalent MAIA values) and 14.66 ± 9.37 dB on MAIA (P < 0.0001). Mean retinal sensitivity in healthy subjects was 18.46 ± 3.10 dB on MP1 (22.44 ± 7.08 dB on their converted equivalent MAIA values) and 28.52 ± 1.12 dB on MAIA (P < 0.0001). Thirty eyes affected by RD (41%) showed retinal areas characterized by sensitivity under 1 dB on MP1, whereas the MAIA examination of the same areas revealed a mean retinal sensitivity of 4.7 dB. Moreover, 28 of these eyes disclosed also areas of absolute scotoma on MP1, but examining the same areas on MAIA, just 13 of these eyes (46%) disclosed an absolute scotoma. In addition, in a subgroup of 6 eyes affected by RD (8%) showing a retinal sensitivity of 20 dB on MP1, the corresponding value on MAIA varied from 26.3 dB to 30.0 dB, with a mean value of 27.8 ± 1.3 dB.
  
  
  CONCLUSIONS
  The MAIA microperimeter provides a more accurate characterization of functional impairment in RD with respect to the MP1 system, especially in cases with low and high retinal sensitivity. MAIA microperimeter could reveal particularly useful in precisely identifying and monitoring subtle changes in retinal sensitivity, especially in view of the availability of therapies aiming at a functional rescue in patients with RD.
authors.affiliation: *Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy; and †Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Maurizio Battaglia
authors.initials: MB
authors.lastname: Parodi
authors.forename: Giacinto
authors.initials: G
authors.lastname: Triolo
authors.forename: Marco
authors.initials: M
authors.lastname: Morales
authors.forename: Enrico
authors.initials: E
authors.lastname: Borrelli
authors.forename: Maria V
authors.initials: MV
authors.lastname: Cicinelli
authors.forename: Maria L
authors.initials: ML
authors.lastname: Cascavilla
authors.forename: Francesco
authors.initials: F
authors.lastname: Bandello
mesh_terms: D000328:Adult; D005260:Female; D005654:Fundus Oculi; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012160:Retina / Q000502:physiology*; D058499:Retinal Dystrophies / Q000175:diagnosis / Q000503:physiopathology*; D012607:Scotoma / Q000175:diagnosis / Q000503:physiopathology*; D012684:Sensory Thresholds; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests / Q000295:instrumentation*; D014794:Visual Fields / Q000502:physiology*