title: Role of Fractional-Flow Reserve in Guiding Percutaneous Revascularization in Stable Coronary Artery Disease.
abstract: Optimal medical therapy unarguably forms the cornerstone of management for patients with stable coronary artery disease. There is, however, a significant body of evidence suggesting that reduction of ischemia can be achieved more effectively with revascularization than medical therapy and can confer significant symptomatic and prognostic advantages. Nonetheless, owing to limitations of coronary angiography and conventional non-invasive functional testing for myocardial ischemia, targeting of hemodynamically significant coronary stenoses for revascularization is often difficult. We discuss the role of invasive fractional-flow reserve evaluation in guiding percutaneous revascularization procedures for patients with stable coronary artery disease and its potential impact on outcomes for these patients.
authors.affiliation: Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA, nikolaos.kakouros@umassmed.edu.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kakouros
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Rade
mesh_terms: D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000150:complications / Q000628:therapy*; D023921:Coronary Stenosis / Q000150:complications; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D012307:Risk Factors