title: Documentation of Ultrastructural Changes in Nucleus and Microvilli by Fish Oil in Experimental Colon Carcinogenesis.
abstract: Fish oil (FO) exerts a chemopreventive effect by regulating apoptosis in colon carcinogenesis. The present study reports the ultrastructural changes in various organelles on supplementation of FO in experimental colon carcinogenesis. The carcinogen treatment led to abnormal nuclear shape and alteration in microvilli number indicating cancer establishment. On the other hand, different ratios of FO and corn oil increased chromatin condensation along with an extensive loss of microvilli in a dose- and time-dependent manner which depicts an increase in apoptosis. The associated ultrastuctural alterations support the facilitation of apoptosis by FO as a mechanism for its beneficial effect in colon carcinogenesis.
authors.affiliation: a Department of Biochemistry , Panjab University , Chandigarh , Punjab , India.
authors.forename: Gayatri
authors.initials: G
authors.lastname: Sharma
authors.affiliation: a Department of Biochemistry , Panjab University , Chandigarh , Punjab , India.
authors.forename: Isha
authors.initials: I
authors.lastname: Rani
authors.affiliation: a Department of Biochemistry , Panjab University , Chandigarh , Punjab , India.
authors.forename: Archana
authors.initials: A
authors.lastname: Bhatnagar
authors.affiliation: a Department of Biochemistry , Panjab University , Chandigarh , Punjab , India.
authors.forename: Navneet
authors.initials: N
authors.lastname: Agnihotri
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002466:Cell Nucleolus / Q000648:ultrastructure*; D003110:Colonic Neoplasms / Q000648:ultrastructure*; D004195:Disease Models, Animal; D005395:Fish Oils / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000648:ultrastructure*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008871:Microvilli / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016588:Anticarcinogenic Agents; D005395:Fish Oils
keywords: Apoptosis; colorectal cancer; corn oil; fish oil; n-3 and n-6 polyunsaturated fatty acids