title: The Role of Antiepileptic Treatment in the Recurrence Rate of Seizures After First Attack: A Randomized Clinical Trial.
abstract: OBJECTIVE
  Epilepsy is a serious, potentially life-shortening brain disorder that occurs in patients of all ages and races. A total of 2-4% of people have experienced seizures at least once in their lifetime. Although treatment usually begins after a seizure, it is an important question whether the first cases of seizure do need to be treated by antiepileptic drugs. In this manner, we compare the recurrence rates of epilepsy in first seizure patients treated with sodium valproic acid as an antiepileptic drug versus a placebo.
  
  
  METHODS
  In a randomized clinical trial study, 101 first seizure patients were randomly divided into two groups: one group was treated with antiepileptic drugs (sodium valproate 200mg, three times a day) and the other group was given a placebo. The recurrence rate of seizures was evaluated and compared between the groups after 6 months of follow up.
  
  
  RESULTS
  Eight recurrence cases were detected. All recurrence cases came from the placebo group, with four patients suffering an additional seizure after four months and between 4-6 month follow up. A comparison of recurrence rate detected a statistically significant difference between the drug group and placebo group.
  
  
  CONCLUSIONS
  Our data shows that the recurrences occurred only in the placebo group with the difference between the recurrence rates in the placebo versus drug-treated was significant. Our results suggest that drug therapy for people after their first seizure attack might reduce the probability of seizure recurrence.
authors.affiliation: Neurology Department, Emam Hossein Medical and educational Center, Shahid Beheshti University of Medical Sciences(SBMU), Tehran, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Assarzadegan
authors.affiliation: School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
authors.forename: Hanif
authors.initials: H
authors.lastname: Tabesh
authors.affiliation: Neurology Department, Emam Hossein Medical and educational Center, Shahid Beheshti University of Medical Sciences(SBMU), Tehran, Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Hesami
authors.affiliation: Emergency Department, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
authors.forename: Hojjat
authors.initials: H
authors.lastname: Derakhshanfar
authors.affiliation: Neurology Department, Emam Hossein Medical and educational Center, Shahid Beheshti University of Medical Sciences(SBMU), Tehran, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Beladi Moghadam
authors.affiliation: School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
authors.forename: Arya
authors.initials: A
authors.lastname: Shoghli
authors.affiliation: Circadian Biologist, London, United Kingdom.
authors.forename: Andrew David
authors.initials: AD
authors.lastname: Beale
authors.affiliation: Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Seyed-Mostafa
authors.initials: SM
authors.lastname: Hosseini-Zijoud
keywords: Epilepsy; Recurrence rate; Seizure; Sodium valproate