title: Immune enhancing nutrition in traumatic brain injury - A preliminary study.
abstract: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Certain patients appear to benefit when they receive immune enhancing additives, such as glutamine, arginine, and omega-3 fatty acids. We hypothesized that TBI patients given enteral feedings containing these supplements may have improved nutrition measures and infection rates when compared to standard tube feedings. This is a retrospective review of patients from a Level-One trauma center from July 2009 to July 2013. A total of 240 TBI patients received either an immune enhancing nutrition (IEN) formula (n = 126), or a standard formula (SF) (n = 114) based on the attending surgeon's preference. Data collected included demographic information, infection information and outcome measures. Patients were similar in terms of age, ISS, head AIS, and initial prealbumin level. Patients receiving IEN were found to have lower rates of blood stream infections (10.3% vs 19.3%, p < 0.05), whereas pneumonia and UTI rates were similar between groups. In addition, both groups had similar rates of all-cause mortality and hospital length of stay, however IEN patients spent longer in the ICU and on ventilators. In TBI patients receiving IEN, prealbumin levels were higher at the second, third, and fourth week of admission (week 2 - 22.2 vs 17.4, p = 0.006; week 3 - 24.6 vs 20.1, p = 0.04; week 4 - 26.3 vs 22.1, p = 0.19; week 5 - 25.8 vs 20.3, p = 0.21). This study suggests that patients with traumatic brain injury who receive IEN are more likely to have increased prealbumin levels perhaps reflecting improved nutrition throughout their hospital stay and may show some benefit in rates of infections, particularly in bacteremia.
authors.affiliation: Orlando Health, Department of Surgical Education, 86 W. Underwood Street, Suite 201, Orlando, FL 32806, USA. Electronic address: tjpainter11@gmail.com.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Painter
authors.affiliation: 1216 Shorecrest Circle, Clermont, FL 34711, USA. Electronic address: jrickerds@gmail.com.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rickerds
authors.affiliation: Department of Surgery Cedars-Sinai Medical Center, 8635 W 3rd St Suite 650-W, Los Angeles, CA 90048, USA. Electronic address: Rodrigo.alban@cshs.org.
authors.forename: Rodrigo F
authors.initials: RF
authors.lastname: Alban
mesh_terms: D000328:Adult; D001120:Arginine / Q000627:therapeutic use*; D016470:Bacteremia / Q000453:epidemiology; D001930:Brain Injuries / Q000628:therapy*; D019587:Dietary Supplements; D004750:Enteral Nutrition; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005260:Female; D005973:Glutamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D015525:Fatty Acids, Omega-3; D011228:Prealbumin; D005973:Glutamine; D001120:Arginine
keywords: Immune-enhancing nutrition; Infection rates; Pre-albumin; Traumatic brain injury