title: Comparison of Therapeutic Effect of Recombinant Tissue Plasminogen Activator by Treatment Time after Onset of Acute Ischemic Stroke.
abstract: We aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) administered at different time windows within the first 6 hours after onset of acute ischemic stroke (AIS). A retrospective analysis was performed of data collected from 194 patients who received rt-PA thrombolysis within 4.5 hours after AIS onset and from 29 patients who received rt-PA thrombolysis between 4.5-6 hours after AIS onset. The National Institutes of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P < 0.05) at 24 hours and 7 days after onset. There was no statistical difference in the modified Rankin score or mortality at day 90 after treatment between the two groups (P > 0.05). In conclusion, AIS patients who received rt-PA treatment between 4.5-6 hours after onset were similar in therapeutic efficacy to those who received rt-PA within 4.5 hours after onset. Our results suggest that intravenous thrombolytic therapy for AIS within 4.5-6 hours after onset is effective and safe.
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Hai-rong
authors.initials: HR
authors.lastname: Wang
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Miao
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Fei-long
authors.initials: FL
authors.lastname: Wang
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Dai
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Ai-hua
authors.initials: AH
authors.lastname: Fei
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Jia-fu
authors.initials: JF
authors.lastname: Liu
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Hao-jun
authors.initials: HJ
authors.lastname: Li
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Sa
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
authors.forename: Shu-ming
authors.initials: SM
authors.lastname: Pan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator