title: Eosinophilia in Dermatologic Disorders.
abstract: Eosinophil infiltration can be observed in skin disorders, such as allergic/immunologic, autoimmune, infectious, and neoplastic diseases. Clinical presentations are variable and include eczematous, papular, urticarial, bullous, nodular, and fibrotic lesions; pruritus is a common symptom in all. In this review, we present representative eosinophilic skin diseases according to their clinical pattern, together with histologic findings and diagnostic procedures. We also discuss the potential roles of eosinophils in the pathogenesis of dermatologic disorder. Current pathogenesis-based diagnostic and therapeutic approaches are outlined.
authors.affiliation: Department of Dermatology, Inselspital, Freiburgstrasse, Bern CH-3010, Switzerland; Institute of Pharmacology, University of Bern, Inselspital, Bern CH-3010, Switzerland.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: de Graauw
authors.affiliation: Department of Dermatology, Inselspital, Freiburgstrasse, Bern CH-3010, Switzerland.
authors.forename: Helmut
authors.initials: H
authors.lastname: Beltraminelli
authors.affiliation: Institute of Pharmacology, University of Bern, Inselspital, Bern CH-3010, Switzerland.
authors.forename: Hans-Uwe
authors.initials: HU
authors.lastname: Simon
authors.affiliation: Department of Dermatology, Inselspital, Freiburgstrasse, Bern CH-3010, Switzerland. Electronic address: dagmar.simon@insel.ch.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Simon
mesh_terms: D016207:Cytokines / Q000378:metabolism; D004802:Eosinophilia / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology*; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000166:cytology / Q000473:pathology*; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology*
chemical_list: D016207:Cytokines
keywords: Atopic dermatitis; Cutaneous lymphoma; Drug hypersensitivity reaction; Eosinophilic dermatitis; Eosinophils; Hypereosinophilic syndromes