title: Highly Efficient Rh-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Nitriles.
abstract: A highly efficient enantioselective hydrogenation of α,β-unsaturated nitriles catalyzed by Rh-(R,R)-f-spiroPhos complex has been developed. With Rh-(R,R)-f-spiroPhos catalyst and under mild conditions, a wide range of α,β-unsaturated nitriles including the (E)- and (Z)-isomers of 3-alkyl-3-aryl, 3,3-diaryl, and 3,3-dialkyl α,β-unsaturated nitriles were hydrogenated to the corresponding chiral nitriles with excellent enantioselectivities (up to 99.9% ee) and high turnover numbers (TON up to 10,000).
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Qiaozhi
authors.initials: Q
authors.lastname: Yan
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Duanyang
authors.initials: D
authors.lastname: Kong
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Meina
authors.initials: M
authors.lastname: Li
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Hou
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Guofu
authors.initials: G
authors.lastname: Zi
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D009570:Nitriles / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D009570:Nitriles; D010720:Phosphines; D013141:Spiro Compounds; D012238:Rhodium; C044646:phosphine