title: DNA flow cytometric analysis in variable types of hydropic placentas.
abstract: BACKGROUND
  Differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management.
  
  
  OBJECTIVE
  We analyzed the nuclear DNA content of various types of hydropic placentas by flowcytometry.
  
  
  METHODS
  DNA ploidy analysis was performed in 20 non-molar (hydropic and non-hydropic spontaneous abortions) and 20 molar (complete and partial moles), formalin-fixed, paraffin-embedded tissue samples by flow cytometry. The criteria for selection were based on the histopathologic diagnosis.
  
  
  RESULTS
  Of 10 cases histologically diagnosed as complete hydatiform mole, 9 cases yielded diploid histograms, and 1 case was tetraploid. Of 10 partial hydatidiform moles, 8 were triploid and 2 were diploid. All of 20 cases diagnosed as spontaneous abortions (hydropic and non-hydropic) yielded diploid histograms.
  
  
  CONCLUSIONS
  These findings signify the importance of the combined use of conventional histology and ploidy analysis in the differential diagnosis of complete hydatidiform mole, partial hydatidiform mole and hydropic abortion.
authors.affiliation: Department of Anatomical Sciences, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Atabaki Pasdar
authors.affiliation: Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Khooei
authors.affiliation: Department of Anatomy and Cell Biology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Fazel
authors.affiliation: Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Rastin
authors.affiliation: Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Nafise
authors.initials: N
authors.lastname: Tabasi
authors.affiliation: Department of Anatomical Sciences, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Tahmineh
authors.initials: T
authors.lastname: Peirouvi
authors.affiliation: Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mahmoudi
keywords: Flow cytometry; Hydatidiform mole; Ploidy; Spontaneous abortion