title: Spatiotemporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema.
abstract: Detection of an early stage of subglottic edema is vital for airway management and prevention of stenosis, a life-threatening condition in critically ill neonates. As an observer for the task of diagnosing edema in vivo, we investigated spatiotemporal correlation (STC) of full-range optical coherence tomography (OCT) images acquired in the rabbit airway with experimentally simulated edema. Operating the STC observer on OCT images generates STC coefficients as test statistics for the statistical decision task. Resulting from this, the receiver operating characteristic (ROC) curves for the diagnosis of airway edema with full-range OCT in-vivo images were extracted and areas under ROC curves were calculated. These statistically quantified results demonstrated the potential clinical feasibility of the STC method as a means to identify early airway edema.
authors.affiliation: Hanbat National University, College of Engineering, School of Basic Sciences, 125 DogSeoDaeRo, YuSeong-Gu, Daejeon 305-719, Republic of Korea.
authors.forename: DongYel
authors.initials: D
authors.lastname: Kang
authors.affiliation: University of California Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California 92617, United States.
authors.forename: Alex
authors.initials: A
authors.lastname: Wang
authors.affiliation: Ludwig-Maximilians-University Munich, Department of Otolaryngology-Head and Neck Surgery, Marchioninistr. 15, Munich 81377, Germany.
authors.forename: Veronika
authors.initials: V
authors.lastname: Volgger
authors.affiliation: University of California Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California 92617, United StatesdUniversity of California Irvine, Department of Biomedical Engineering, Irvine, California 92617, United StateseUniversity of California Ir.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
authors.affiliation: University of California Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California 92617, United StatesdUniversity of California Irvine, Department of Biomedical Engineering, Irvine, California 92617, United StateseUniversity of California Ir.
authors.forename: Brian J F
authors.initials: BJ
authors.lastname: Wong
mesh_terms: D000818:Animals; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D011654:Pulmonary Edema / Q000175:diagnosis*; D011817:Rabbits; D012815:Signal Processing, Computer-Assisted; D041623:Tomography, Optical Coherence / Q000379:methods*