title: Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation ofN-(3,3,3-trifluoroethyl)-N'-substituted ureas.
abstract: A new method is described for producing 3,3,3-trifluoroethyl isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP Human Tumor Cell Line Screening Program at a single high dose (10-5M). The moderate anticancer activity was shown against some types of cancer on the individual human cell lines for leukemia, non-small cell lung cancer and renal cancer.
authors.affiliation: Institute of Physiologically Active Compounds, Severnyi pr. 1, Chernogolovka, Moscow region, 142432, Russia.
authors.forename: Elena L
authors.initials: EL
authors.lastname: Luzina
authors.affiliation: University of Pennsylvania, Perelman School of Medicine, Department of Radiology, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
authors.forename: Anatoliy V
authors.initials: AV
authors.lastname: Popov
keywords: 3,3,3-trifluoroethyl ureas; anticancer activity; perfluoroisobutene, 3,3,3-trifluoroethyl isocyanate; synthesis