title: Association of Nicotinamide-N-Methyltransferase Gene rs694539 Variant with Epilepsy.
abstract: Here, we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with epilepsy in a case-control study of 215 patients with epilepsy and 239 healthy controls (χ (2) = 11.641, P = 0.003). The individuals with the GG genotype revealed protection against epilepsy (χ (2) = 5.866, P = 0.015, OR = 0.623, 95 % CI = 0.425-0.915), whereas the individuals with the AA genotype showed statistically significant increased risk for epilepsy (χ (2) = 8.676, P = 0.003, OR = 5.479, 95 % CI = 1.553-19.337). In addition, the G allele was protective against epilepsy (χ (2) = 8.676, P = 0.003, OR = 0.183, 95 % CI = 0.052-0.644); on the contrary, the A allele was a genetic risk factor for epilepsy (χ (2) = 5.866, P = 0.015, OR = 1.604, 95 % CI = 1.093-2.354). Stratification analysis revealed that the association was statistically significant in male patients with epilepsy (χ (2) = 6.682, P = 0.035). However, the statistical power was only 0.33 in female patients with epilepsy (χ (2) = 5.275, P = 0.072). This finding, for the first time, suggests the involvement of the NNMT gene rs694539 variant in the etiology of epilepsy.
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380, Kocaeli, Turkey.
authors.forename: Gensay
authors.initials: G
authors.lastname: Sazci
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380, Kocaeli, Turkey.
authors.forename: Bilgen
authors.initials: B
authors.lastname: Sazci
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380, Kocaeli, Turkey. alisazci@gmail.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Sazci
authors.affiliation: Department of Neurology, Istanbul Faculty of Medicine, University of Istanbul, 34260, Capa, Istanbul, Turkey.
authors.forename: Halil Atilla
authors.initials: HA
authors.lastname: Idrisoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D004827:Epilepsy / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D050903:Nicotinamide N-Methyltransferase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: C494406:NNMT protein, human; D050903:Nicotinamide N-Methyltransferase
keywords: Association; Epilepsy; Gender association; NNMT gene; rs694539