title: [Graft-versus-host disease, a rare complication of lung transplantation].
abstract: Graft-versus-host disease (GVHD) is a classic and frequent multisystemic complication of bone marrow allografts. It has also been reported after the transplantation of solid organs such as the liver or gut. Recent cases of GVHD have been reported after lung and heart-lung transplant. Skin, liver, gastrointestinal tract and bone marrow are the organ preferentially affected by GVHD. Corticosteroid is the first line treatment of GVHD. The prognosis reported in solid organ transplants is poor with infectious complications favoured by immunosuppressive therapy. In this article, we report a case of a patient with cystic fibrosis who presented a probable GVHD 18 months after a lung transplant and a literature review of similar cases.
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France; Centre de référence des maladies rares pulmonaires, 69000 Lyon, France. Electronic address: helene.morisse@yahoo.fr.
authors.forename: H
authors.initials: H
authors.lastname: Morisse-Pradier
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Nove-Josserand
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France; Centre de référence des maladies rares pulmonaires, 69000 Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Philit
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France; Centre de référence des maladies rares pulmonaires, 69000 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Senechal
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France; Université Lyon 1, 69007 Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Berger
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France; Université Lyon 1, 69007 Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Callet-Bauchu
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France; Université Lyon 1, 69007 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Traverse-Glehen
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Maury
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Grima
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Tronc
authors.affiliation: Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France; Centre de référence des maladies rares pulmonaires, 69000 Lyon, France; Université Lyon 1, 69007 Lyon, France; INRA, UMR754, 69007 Lyon, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Mornex
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000628:therapy*; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy
keywords: Chimerism; Chimérisme; Graft-versus-host disease; Lung transplantation; Maladie du greffon contre l’hôte; Transplantation pulmonaire