title: Oleanolic Acid, a Compound Present in Grapes and Olives, Protects against Genotoxicity in Human Mammary Epithelial Cells.
abstract: Oleanolic acid (AO) and maslinic acid (MA) are constituents of the skins of different fruits, including olives and white or red grapes. Although both compounds are known to have beneficial properties against different types of cancers, thus far, there are no studies about their chemopreventive effects in human breast cancer. Thus, we sought to elucidate whether both compounds possess chemopreventive activity. Two cell lines of human breast cancer cells and one noncancerous human mammary epithelial cells were used to determine the effects of OA and MA. The results showed that OA inhibited the proliferation and increased the oxidative stress of highly invasive cells. Additionally, OA decreased oxidative stress and oxidative damage to the DNA in human mammary epithelial cells. These results suggest that OA could act as a chemopreventive agent in human breast cancer and could inhibit the proliferation of highly invasive breast cancer cells.
authors.affiliation: Immunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. csquesad@ujaen.es.|Centro de Estudios Avanzados en Olivar y Aceites de Oliva, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. csquesad@ujaen.es.|Agrifood Campus of International Excellence, ceiA3, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. csquesad@ujaen.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sánchez-Quesada
authors.affiliation: Immunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. albiedma@ujaen.es.|Centro de Estudios Avanzados en Olivar y Aceites de Oliva, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. albiedma@ujaen.es.|Agrifood Campus of International Excellence, ceiA3, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. albiedma@ujaen.es.
authors.forename: Alicia
authors.initials: A
authors.lastname: López-Biedma
authors.affiliation: Immunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. jgaforio@ujaen.es.|Centro de Estudios Avanzados en Olivar y Aceites de Oliva, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. jgaforio@ujaen.es.|Agrifood Campus of International Excellence, ceiA3, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain. jgaforio@ujaen.es.
authors.forename: José J
authors.initials: JJ
authors.lastname: Gaforio
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001943:Breast Neoplasms / Q000473:pathology / Q000517:prevention & control*; D049109:Cell Proliferation / Q000187:drug effects; D004249:DNA Damage; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000378:metabolism* / Q000473:pathology; D031658:Olea / Q000737:chemistry*; D009828:Oleanolic Acid / Q000737:chemistry*; D027843:Vitis / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009828:Oleanolic Acid
keywords: MCF10A; MCF7; MDA-MB-231; antitumoral; chemopreventive; maslinic acid; virgin olive oil; wine