title: That's a Phat Antidote: Intravenous Fat Emulsions and Toxicological Emergencies.
abstract: Health care providers in the emergency department (ED) frequently find themselves caring for patients who may have overdosed on a medication(s) or other toxic substance. These patients can prove to be a challenge, as providers must try to determine the substance(s) involved so that the appropriate treatment can be initiated. For those patients who are hemodynamically unstable upon presentation, it is important to note that supportive care is of the utmost importance, as there are few substances that have antidotes available. In these situations, lipid emulsion can be considered. This is especially true in the setting of the following toxicities: local anesthetics, β-blockers, calcium channel blockers, and the tricyclic antidepressants. Even though lipid emulsion may not be used that frequently in the ED, it is important to be aware of its role in the setting of toxicological emergencies, how it should be dosed and administered, and the necessary safety precautions.
authors.affiliation: Charleston Area Medical Center, Charleston, West Virginia (Drs Schultz, Reed, and Justice); University of Charleston School of Pharmacy, Charleston, West Virginia (Drs Schultz, Justice, and Lewis); West Virginia University School of Pharmacy, Morgantown (Drs Schultz and Justice); and KentuckyOne Health, University of Louisville Hospital, Louisville, Kentucky (Dr Weant).
authors.forename: Amy E
authors.initials: AE
authors.lastname: Schultz
authors.forename: Temeka
authors.initials: T
authors.lastname: Lewis
authors.forename: Brittany S
authors.initials: BS
authors.lastname: Reed
authors.forename: Kyle A
authors.initials: KA
authors.lastname: Weant
authors.forename: Stephanie Baker
authors.initials: SB
authors.lastname: Justice
mesh_terms: D000931:Antidotes / Q000008:administration & dosage*; D004638:Emergency Treatment; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D006801:Humans; D011041:Poisoning / Q000628:therapy*
chemical_list: D000931:Antidotes; D005217:Fat Emulsions, Intravenous