title: High Angiopoietin-1 levels predict a good functional outcome within 72 h of an aneurysmal subarachnoid hemorrhage: A prospective study from a single center.
abstract: BACKGROUND
  The consequences of aneurysmal subarachnoid hemorrhage (aSAH) are lifelong and fatal. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) play an important role in the regulation of vascular structure and function. Our study examined the association between angiopoietin levels and functional outcomes among aSAH patients.
  
  
  METHODS
  We enrolled 37 aSAH patients and 39 controls (matched on age and sex) at the Department of Neurosurgery in Tianjin Medical University General Hospital. Serum Ang-1, Ang-2, and Tie-2 levels were collected at 8, 24, and 72 hours post-hemorrhage. After a 3-month follow-up period, patient outcomes were evaluated using the Glasgow Outcome Score (GOS). Logistic regression examined the association between angiopoietin levels and outcomes (good [GOS: 4-5] vs. poor [GOS: 1-3]).
  
  
  RESULTS
  aSAH patients had higher levels of Ang-1 at 8 hours post-hemorrhage compared to controls. Among aSAH patients, Ang-1 levels at 8, 24, and 72 hours post-hemorrhage were higher among patients with a good outcome. Compared to patients with low Ang-1 levels, high Ang-1 levels at 72 hours post-hemorrhage were associated with a good outcome.
  
  
  CONCLUSIONS
  High Ang-1 levels were associated with a good functional outcome after aSAH. Abnormal angiopoietin levels may disrupt the blood-brain barrier and contribute to functional outcomes in aSAH patients.
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: sinuosiwo@sina.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: yetian1986@gmail.com.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: 54454241@qq.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: huijiewei@126.com.
authors.forename: Huijie
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: zilongzhaotianjin@hotmail.com.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: jianghope@gmail.com.
authors.forename: Rongcai
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: shuyuanyue@sina.com.
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Yue
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: jianningzhang@hotmail.com.
authors.forename: Jianning
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D042683:Angiopoietin-1 / Q000097:blood*; D042702:Angiopoietin-2 / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D042787:Receptor, TIE-2 / Q000097:blood; D013345:Subarachnoid Hemorrhage / Q000097:blood*; D013997:Time Factors
chemical_list: D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042787:Receptor, TIE-2
keywords: Aneurysm; Angiopoietin; Clinical trial; Early brain injury; Subarachnoid hemorrhage