title: Gene polymorphisms related to insulin resistance and gene-environment interaction in colorectal cancer risk.
abstract: OBJECTIVE
  Insulin resistance (IR) is an established risk factor for colorectal cancer (CRC) and both IR and CRC physiologically overlap. As such, this study explored the relationship of IR-related gene polymorphisms and CRC risk.
  
  
  METHODS
  A total of 400 case-control pairs were profiled in terms of their lifestyle, dietary habits and blood sample. Classification and regression tree (CART) and generalized multi-factor dimensionality reduction (GMDR) were employed to test the gene-environment interactions in CRC risk.
  
  
  RESULTS
  ADIPOQ rs2241766 TG + GG, ADIPOQ rs1501299 GT + TT and CAPN-10 rs3792267 GA + AA were significantly related to CRC risk. In CART, individuals with high red meat consumption, CAPN-10 rs3792267 GG, ADIPOQ rs1501299 GG and ADIPOQ rs2241766 TG + GG had an OR of 1.821 (95% CI = 1.124-2.951). The overall best GMDR model including the four factors had the maximal TBA (0.5943) and CVC (10/10) (p = 0.0010). Subjects with high red meat consumption and the three risk genotypes had a CRC risk 10.195-times (95% CI = 2.164-48.030) greater than those with low red meat and null risk genotypes.
  
  
  CONCLUSIONS
  ADIPOQ rs2241766, ADIPOQ rs1501299 and CAPN-10 rs3792267 are significantly associated with CRC risk and the combination of the three polymorphisms and red meat affect CRC risk.
authors.affiliation: a Department of Epidemiology and Biostatistics , West China School of Public Health, Sichuan University , Chengdu , Sichuan , PR China .|b Department of Epidemiology , School of Public Health, Shanxi Medical University , Taiyuan , Shanxi , PR China .
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Hu
authors.affiliation: a Department of Epidemiology and Biostatistics , West China School of Public Health, Sichuan University , Chengdu , Sichuan , PR China .|c Department of Health Care , Chengdu Wenjiang District Maternal and Child Health Hospital , Chengdu , Sichuan , PR China , and.
authors.forename: Fei
authors.initials: F
authors.lastname: Feng
authors.affiliation: a Department of Epidemiology and Biostatistics , West China School of Public Health, Sichuan University , Chengdu , Sichuan , PR China .
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Li
authors.affiliation: a Department of Epidemiology and Biostatistics , West China School of Public Health, Sichuan University , Chengdu , Sichuan , PR China .
authors.forename: Ping
authors.initials: P
authors.lastname: Yuan
authors.affiliation: a Department of Epidemiology and Biostatistics , West China School of Public Health, Sichuan University , Chengdu , Sichuan , PR China .
authors.forename: Rongsheng
authors.initials: R
authors.lastname: Luan
authors.affiliation: d Department of Intestinal Surgery , Sichuan Cancer Hospital , Sichuan , PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yan
authors.affiliation: a Department of Epidemiology and Biostatistics , West China School of Public Health, Sichuan University , Chengdu , Sichuan , PR China .
authors.forename: Wenhui
authors.initials: W
authors.lastname: Liu
authors.affiliation: a Department of Epidemiology and Biostatistics , West China School of Public Health, Sichuan University , Chengdu , Sichuan , PR China .
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
keywords: Colorectal cancer; insulin resistance; interaction; single nucleotide polymorphism