title: Effects of anthocyanins from purple sweet potato (Ipomoea batatas L. cultivar Eshu No. 8) on the serum uric acid level and xanthine oxidase activity in hyperuricemic mice.
abstract: This study was aimed at evaluating the hypouricemic effect of the anthocyanin-rich purple sweet potato extract (APSPE). In vitro, APSPE has been proved to significantly inhibit XO activity in a dose-dependent manner. In vivo, APSPE could not only inhibit the XO activity in mouse liver, but also reduce the serum uric acid level in hyperuricemic mice and affect the expression of mRNA levels of related renal transporters, such as mURAT1, mGLUT9, mOAT1 and mOCTN2. Moreover, APSPE could effectively regulate BUN and Cr levels to normal and decrease the inflammatory cellular influx in the tubule of the hyperuricemic mice. This study indicates the potential clinical utility of APSPE as a safe and effective anti-hyperuricemia bioactive agent or functional food.
authors.affiliation: College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. zjl_ljz@mail.hzau.edu.cn.
authors.forename: Zi-Cheng
authors.initials: ZC
authors.lastname: Zhang
authors.forename: Guan-Hua
authors.initials: GH
authors.lastname: Su
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Luo
authors.forename: Ya-Lu
authors.initials: YL
authors.lastname: Pang
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Jia-Hao
authors.initials: JH
authors.lastname: Wen
authors.forename: Jiu-Liang
authors.initials: JL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage* / Q000737:chemistry; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics / Q000378:metabolism; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000188:drug therapy*; D027723:Ipomoea batatas / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D027362:Organic Anion Transport Protein 1 / Q000235:genetics / Q000378:metabolism; D027361:Organic Anion Transporters / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D014527:Uric Acid / Q000097:blood*; D014969:Xanthine Oxidase / Q000097:blood* / Q000235:genetics
chemical_list: D000872:Anthocyanins; D051246:Glucose Transport Proteins, Facilitative; D027362:Organic Anion Transport Protein 1; D027361:Organic Anion Transporters; D010936:Plant Extracts; C109687:Slc22a12 protein, mouse; C105033:Slc22a6 protein, mouse; C498775:Slc2a9 protein, mouse; D014527:Uric Acid; D014969:Xanthine Oxidase