title: [Drugs Effect on Cognition in the Elderly].
abstract: Many drugs can affect cognitive function in the elderly. Anticholinergic and psychotropic drugs can cause or exacerbate cognitive impairment and can increase the occurrence of dementia in the elderly. In healthy elderly adults, antihypertensive drugs could improve cognition and reduce the dementia risk. By contrast, randomized clinical trials evaluating the effect of statins and nonsteroidal anti-inflammatory drugs have not shown significant cognitive effect.
authors.forename: Christine
authors.initials: C
authors.lastname: Brefel-Courbon
mesh_terms: D000368:Aged / Q000523:psychology*; D000375:Aging / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000009:adverse effects / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects*; D003704:Dementia / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D018680:Cholinergic Antagonists; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011619:Psychotropic Drugs