title: Association of immune response to endothelial cell growth factor with early disseminated and late manifestations of Lyme disease but not posttreatment Lyme disease syndrome.
abstract: Endothelial cell growth factor has been recently proposed as a potential autoantigen in manifestations of Lyme disease that are thought to involve immune-mediated mechanisms. Our findings indicate that a humoral immune response to this protein is not associated with posttreatment Lyme disease syndrome.
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York.
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Tang
authors.affiliation: MassBiologics, University of Massachusetts Medical School, Boston.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Klempner
authors.affiliation: Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York.
authors.forename: Gary P
authors.initials: GP
authors.lastname: Wormser
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Marques
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York.
authors.forename: Armin
authors.initials: A
authors.lastname: Alaedini
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D015748:Borrelia burgdorferi Group / Q000276:immunology; D005260:Female; D006801:Humans; D056724:Immunity, Humoral; D007074:Immunoglobulin G / Q000097:blood; D008193:Lyme Disease / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D000907:Antibodies, Bacterial; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G
keywords: Borrelia burgdorferi; Lyme disease; antibody; endothelial cell growth factor; posttreatment Lyme disease syndrome