title: Coefficient of Friction of Human Corneal Tissue.
abstract: OBJECTIVE
  A novel property evaluation methodology was used to determine the elusive value for the human corneal coefficient of friction (CoF).
  
  
  METHODS
  Using a microtribometer on 28 fresh human donor corneas with intact epithelia, the CoF was determined in 4 test solutions (≥5 corneas/solution): tear-mimicking solution (TMS) in borate-buffered saline (TMS-PS), TMS in phosphate-buffered saline (TMS-PBS), TMS with HEPES-buffered saline (TMS-HEPES), and tear-like fluid in PBS (TLF-PBS).
  
  
  RESULTS
  Mean (SD) CoF values ranged from 0.006 to 0.015 and were 0.013 (0.010) in TMS-PS, 0.006 (0.003) in TMS-PBS, 0.014 (0.005) in TMS-HEPES, and 0.015 (0.009) in TLF-PBS. Statistically significant differences were shown for TMS-PBS versus TLF (P = 0.0424) and TMS-PBS versus TMS-HEPES (P = 0.0179), but not for TMS-PBS versus TMS-PS (P = 0.2389).
  
  
  CONCLUSIONS
  Successful measurement of the fresh human corneal tissue CoF was demonstrated, with values differing in the evaluated buffer solutions, within this limited sample size.
authors.affiliation: *Johnson & Johnson Vision Care, Inc, Jacksonville, FL; and †SuSoS AG, Dübendorf, Switzerland.
authors.forename: Tawnya
authors.initials: T
authors.lastname: Wilson
authors.forename: Rudolf
authors.initials: R
authors.lastname: Aeschlimann
authors.forename: Samuele
authors.initials: S
authors.lastname: Tosatti
authors.forename: Youssef
authors.initials: Y
authors.lastname: Toubouti
authors.forename: Joseph
authors.initials: J
authors.lastname: Kakkassery
authors.forename: Katherine
authors.initials: K
authors.lastname: Osborn Lorenz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003315:Cornea / Q000502:physiology*; D005260:Female; D017276:Friction / Q000502:physiology*; D006801:Humans; D008153:Lubrication; D008297:Male; D008422:Materials Testing / Q000295:instrumentation*; D008954:Models, Biological; D013314:Stress, Mechanical; D014019:Tissue Donors