title: Peripherally Inserted Central Catheter-Related Infections in a Cohort of Hospitalized Adult Patients.
abstract: OBJECTIVE
  To determine the incidence and the risks factors of peripherally inserted central catheter (PICC)-related infectious complications.
  
  
  METHODS
  Medical charts of every in-patient that underwent a PICC insertion in our hospital between January 2010 and October 2013 were reviewed. All PICC-related infections were recorded and categorized as catheter-related bloodstream infections (CR-BSI), exit-site infections, and septic thrombophlebitis.
  
  
  RESULTS
  Nine hundred and twenty-three PICCs were placed in 644 unique patients, mostly male (68.3%) with a median age of 58 years. 31 (3.4%) PICC-related infections occurred during the study period corresponding to an infection rate of 1.64 per 1000 catheter-days. We observed 27 (87.1%) CR-BSI, corresponding to a rate of 1.43 per 1000 catheter-days, 3 (9.7%) septic thrombophlebitis, and 1 (3.2%) exit-site infection. Multivariate logistic regression analysis showed a higher PICC-related infection rate with chemotherapy (odds ratio (OR) 7.2-confidence interval (CI) 95% [1.77-29.5]), auto/allograft (OR 5.9-CI 95% [1.2-29.2]), and anti-coagulant therapy (OR 2.2-95% [1.4-12]).
  
  
  CONCLUSIONS
  Chemotherapy, auto/allograft, and anti-coagulant therapy are associated with an increased risk of developing PICC-related infections.
  Chemotherapy, auto/allograft, and anti-coagulant therapy are important predictors of PICC-associated infections. A careful assessment of these risk factors may be important for future success in preventing PICC-related infections.
authors.affiliation: Radiology Department, Percy Military Teaching Hospital, 101 avenue Henri Barbusse, 92140, Clamart, France. caroline.bouzad@gmail.com.
authors.forename: Caroline
authors.identifier: http://orcid.org/0000-0002-7210-0823
authors.initials: C
authors.lastname: Bouzad
authors.affiliation: Military Centre for Epidemiology and Public Health (CESPA), GSBdD, 111 avenue de la Corse - Caserne Audéoud, 13007, Marseille-Aubagne, France. duronsandrine@yahoo.fr.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Duron
authors.affiliation: Bacteriology Department, Begin Military Teaching Hospital, 69 avenue de Paris, 94160, Saint-Mandé, France. aurorebousquet@yahoo.fr.
authors.forename: Aurore
authors.initials: A
authors.lastname: Bousquet
authors.affiliation: Radiology Department, Percy Military Teaching Hospital, 101 avenue Henri Barbusse, 92140, Clamart, France. fxa0160@hotmail.com.
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Arnaud
authors.affiliation: Radiology Department, Begin Military Teaching Hospital, 69 avenue de Paris, 94160, Saint-Mandé, France. laura.valbousquet@gmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Valbousquet
authors.affiliation: Radiology Department, Percy Military Teaching Hospital, 101 avenue Henri Barbusse, 92140, Clamart, France. weberdonatgabrielle@yahoo.fr.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Weber-Donat
authors.affiliation: Radiology Department, Percy Military Teaching Hospital, 101 avenue Henri Barbusse, 92140, Clamart, France. cteriitehau@me.com.
authors.forename: Christophe
authors.initials: C
authors.lastname: Teriitehau
authors.affiliation: Radiology Department, Percy Military Teaching Hospital, 101 avenue Henri Barbusse, 92140, Clamart, France. jacques.baccialone@wanadoo.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Baccialone
authors.affiliation: Radiology Department, Percy Military Teaching Hospital, 101 avenue Henri Barbusse, 92140, Clamart, France. potet_julien@yahoo.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Potet
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000706:statistics & numerical data*; D002406:Catheterization, Peripheral / Q000009:adverse effects / Q000706:statistics & numerical data; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Central venous access lines; Fluoroscopy; Imaging; Peripheral vascular; Venous intervention