title: Light-induced nitric oxide release from physiologically stable porous coordination polymers.
abstract: The development of nitric oxide (NO) releasing materials has been of significant importance due to their application in cell biology and biomedicine. Besides the macromolecular scaffold dangling NO releasing moiety, porous materials have been used to host such NO releasing molecules. Here we synthesized a series of porous coordination polymers (PCPs), in which N-nitrosamine functional groups as photoactive NO donors were introduced into the framework scaffolds by post-synthetic nitrosation of amine functionalized analogous PCPs. We further demonstrated a controlled release of NO from the PCPs by light irradiation. Though isoreticular frameworks based on octanuclear clusters of titanium or aluminium ions were chosen due to their water-stability, the frameworks showed difference in stability in cell culture media; while aluminium frameworks were less stable in water and physiological media, the titanium analogue was highly stable even under physiological conditions.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Chiwon
authors.initials: C
authors.lastname: Kim
authors.forename: Stéphane
authors.initials: S
authors.lastname: Diring
authors.forename: Shuhei
authors.initials: S
authors.lastname: Furukawa
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitagawa
mesh_terms: D000327:Adsorption; D000535:Aluminum / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D016227:Benzoquinones / Q000737:chemistry; D018360:Crystallography, X-Ray; D007097:Imines / Q000737:chemistry; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors; D009584:Nitrogen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014025:Titanium / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000588:Amines; D016227:Benzoquinones; D007097:Imines; D020030:Nitric Oxide Donors; D011108:Polymers; D012997:Solvents; D014867:Water; D009569:Nitric Oxide; C004532:quinone; D000535:Aluminum; D014025:Titanium; D009584:Nitrogen