title: Default Mode Network Activity Predicts Early Memory Decline in Healthy Young Adults Aged 18-31.
abstract: Functional magnetic resonance imaging (fMRI) research conducted in healthy young adults is typically done with the assumption that this sample is largely homogeneous. However, studies from cognitive psychology suggest that long-term memory and attentional control begin to diminish in the third decade of life. Here, 100 participants between the ages of 18 and 31 learned Lithuanian translations of English words in an individual differences study using fMRI. Long-term memory ability was operationalized for each participant by deriving a memory score from 3 convergent measures. Age of participant predicted memory score in this cohort. In addition, degree of deactivation during initial encoding in a set of regions occurring largely in the default mode network (DMN) predicted both age and memory score. The current study demonstrates that early memory decline may partially be accounted for by failure to modulate activity in the DMN.
authors.affiliation: VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Nelson
authors.affiliation: Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA.
authors.forename: Neil K
authors.initials: NK
authors.lastname: Savalia
authors.affiliation: Department of Neurology.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Fishell
authors.affiliation: Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA.
authors.forename: Adrian W
authors.initials: AW
authors.lastname: Gilmore
authors.affiliation: Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA.
authors.forename: Fan
authors.initials: F
authors.lastname: Zou
authors.affiliation: Department of Neurology Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Balota
authors.affiliation: Department of Radiology, Washington University in St Louis, St Louis, MO 63110, USA Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA.
authors.forename: Kathleen B
authors.initials: KB
authors.lastname: McDermott
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology; D000066492:Cognitive Aging / Q000502:physiology*; D015331:Cohort Studies; D006801:Humans; D007206:Individuality; D007802:Language; D007858:Learning / Q000502:physiology; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D057567:Memory, Long-Term / Q000502:physiology*; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011379:Prognosis; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: aging; deactivations; default mode network; learning; memory