title: Serum uric acid is associated with cardiac diastolic dysfunction among women with preserved ejection fraction.
abstract: Serum uric acid (SUA) is associated with the severity and prognosis of systolic heart failure. We investigated the potential association between SUA and cardiac diastolic dysfunction among total of 744 cardiac patients (202 women and 542 men) who had preserved left ventricular ejection fraction. Presence of diastolic dysfunction was assessed by echocardiographic data, plasma B-type natriuretic peptide concentration, and left ventricular hypertrophy. Univariate analysis showed that the prevalence of diastolic dysfunction increased with increasing SUA value in women, but not in men. When sex-nonspecific SUA quartiles were used, multivariate logistic regression analysis, among female patients who were not taking uric acid lowering medication, showed that the third (SUA, 5.7-6.4 mg) and the fourth (SUA, ≥6.5 mg/dl) SUA quartiles were associated with diastolic dysfunction with an odds ratio of 3.25 (P < 0.05) and 8.06 (P < 0.001), respectively, when compared with the first SUA quartile (≤4.7 mg/dl). When sex-specific SUA quartiles were used among these population, multivariate logistic regression analysis showed that the fourth SUA quartile (≥5.7 mg/dl) was associated with diastolic dysfunction with an odds ratio of 5.34 (P < 0.05) when compared with the first SUA quartile (≤4.1 mg/dl). By contrast, the relationship between SUA and diastolic dysfunction was not significant in men, irrespective of which of the sex-nonspecific or sex-specific SUA quartiles were used. These data indicated that among cardiac patients with preserved ejection fraction, SUA was significantly associated with diastolic dysfunction in women but not in men.
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Shinpei
authors.initials: S
authors.lastname: Nogi
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Fujita
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Shun
authors.initials: S
authors.lastname: Kizawa
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Morita
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Takahide
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Sakane
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Sohmiya
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hoshiga
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan ishizaka@poh.osaka-med.ac.jp.
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003971:Diastole; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D012737:Sex Factors; D013318:Stroke Volume; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D014527:Uric Acid
keywords: diastolic dysfunction; preserved ejection fraction; sex difference; uric acid