title: [Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata].
abstract: OBJECTIVE
  To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.
  
  
  METHODS
  The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice.
  
  
  RESULTS
  Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), moslosooflavone (9), mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).
  
  
  CONCLUSIONS
  All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.
authors.forename: Lin-lin
authors.initials: LL
authors.lastname: Jing
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.forename: Peng-cheng
authors.initials: PC
authors.lastname: Fan
authors.forename: Zheng-ping
authors.initials: ZP
authors.lastname: Jia
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Ma
mesh_terms: D000473:Alkanes; D000818:Animals; D005419:Flavonoids; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D064209:Phytochemicals / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D030441:Saussurea / Q000737:chemistry*; D012855:Sitosterols; D012997:Solvents
chemical_list: D000473:Alkanes; D005419:Flavonoids; D064209:Phytochemicals; D010936:Plant Extracts; D012855:Sitosterols; D012997:Solvents; C035064:5-hydroxy-7,8-dimethoxyflavone; C025473:gamma-sitosterol; C002763:octacosane