title: Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study.
abstract: BACKGROUND
  Previous studies suggested that expression of cyclin-dependent kinase 5 (CDK5) may promote the migration and invasion of human glioma cells. In this study, we aimed to evaluate the clinical value of CDK5 in different grades of glioma in relation to Ki-67 labeling index (LI).
  
  
  METHODS
  We firstly assessed by immunohistochemistry the expression of CDK5 in 152 glioma tissues and 16 normal brain tissues and further explored the relationship between CDK5 expression and other clinical features.
  
  
  RESULTS
  The positive ratio of CDK5 in gliomas (57.2%) was higher than that in normal brain tissues (12.5%, P=0.001). Difference of CDK5 expression among four World Health Organization (WHO) grades was statistically significant (P=0.001). The significant differences of CDK5 expression were also observed between WHO I glioma (34.8%) and WHO III glioma (62.5%), as well as WHO IV glioma (82.8%; P=0.026, P<0.001, respectively). Furthermore, Spearman's rank correlation confirmed that CDK5 was positively correlated with the pathological grade of glioma (r=0.831, P<0.001). The CDK5 expression was also positively correlated with Ki-67 LI (r=0.347, P<0.001).
  
  
  CONCLUSIONS
  The current result suggests that CDK5 may play an essential role in the tumorigenesis and aggressiveness of gliomas.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Ruan
authors.initials: R
authors.lastname: Yushan
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wenjie
authors.affiliation: Department of Radiology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Huang
authors.initials: H
authors.lastname: Suning
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Dang
authors.initials: D
authors.lastname: Yiwu
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Tengfei
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Wickramaarachchi Mihiranganee
authors.initials: WM
authors.lastname: Madushi
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Luo
authors.initials: L
authors.lastname: Feifei
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Changwen
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Wen
authors.initials: W
authors.lastname: Xin
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China.
authors.forename: Gopaul
authors.initials: G
authors.lastname: Roodrajeetsing
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China. lizuyun8877@aliyun.com.
authors.forename: Li
authors.initials: L
authors.lastname: Zuyun
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic China. chen_gang_triones@163.com.
authors.forename: Chen
authors.initials: C
authors.lastname: Gang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D051360:Cyclin-Dependent Kinase 5 / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D051360:Cyclin-Dependent Kinase 5; C495905:CDK5 protein, human