title: [Safety of influenza vaccines in risk groups: analysis of adverse events following immunization reported in Valencian Community from 2005 to 2011].
abstract: OBJECTIVE
  To evaluate reports of adverse events following influenza immunization by sex, risk and age groups in Valencian Community from 2005 to 2011.
  
  
  METHODS
  A pharmacoepidemiological descriptive cross-sectional observational study based on the reports of adverse events following immunization (AEFI) against influenza, registered through the Vaccination Information System (SIV) of Valencian Community from 1 January 2005 until 31 December 2011 was done.
  
  
  RESULTS
  During the study period 5,107,790 doses of vaccine against influenza were reported, with an AEFI incidence of 1.94 per 100,000 (95% CI 1.59 to 2.36), and 228,094 doses of vaccine for influenza A (H1N1) pdm09 (96.45 per 100,000, 95%CI 84.52-110.06). The 70.71% (70) and 64.55% (142), respectively, of AEFI were in women. The healthcare workers group had a higher reporting rate for seasonal influenza (25.35 per 100,000; 95%CI: 17.65-36.40) and for influenza A(H1N1) pdm09 (864.13 per 100,000; 95%CI 714.38-1044.93) during the study period.
  
  
  CONCLUSIONS
  Vaccines against influenza administered during the study had a high safety profile in both populations with disease risk and other susceptible target groups of vaccination. Adverse reactions reported during the study mostly coincide with those described in the summary of product characteristics of vaccines.
authors.affiliation: Ana Maria Alguacil Ramos, Dirección General de Salud Pública, Avd Cataluña nº21, 46020 Valencia, Spain. alguacil_ana@gva.es.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Alguacil-Ramos
authors.forename: Teresa Ma
authors.initials: TM
authors.lastname: Garrigues-Pelufo
authors.forename: Julio
authors.initials: J
authors.lastname: Muelas-Tirado
authors.forename: Antonio
authors.initials: A
authors.lastname: Portero-Alonso
authors.forename: Jordi
authors.initials: J
authors.lastname: Pérez-Panadés
authors.forename: Jaime
authors.initials: J
authors.lastname: Fons-Martínez
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002908:Chronic Disease / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004890:Erythema / Q000209:etiology; D005221:Fatigue / Q000209:etiology; D005260:Female; D006282:Health Personnel / Q000706:statistics & numerical data; D006801:Humans; D016867:Immunocompromised Host; D007252:Influenza Vaccines / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000453:epidemiology; D016273:Occupational Exposure; D010146:Pain / Q000209:etiology; D011247:Pregnancy; D012306:Risk; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D035862:Vulnerable Populations / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines