title: miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof.
abstract: The importance of individual target genes for miRNA activity has been difficult to establish. In this issue of Immunity, Lu et al. (2015) disrupt the miR-155 binding site in the SOCS1 3' UTR in the mouse germline and show that this axis is important for T and NK cell function.
authors.affiliation: Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Huffaker
authors.affiliation: Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: ryan.oconnell@path.utah.edu.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: O'Connell
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D035683:MicroRNAs / Q000235:genetics*; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D035683:MicroRNAs; D050826:Suppressor of Cytokine Signaling Proteins