title: Mild Cognitive Impairment in Early Parkinson's Disease Using the Movement Disorder Society Task Force Criteria: Cross-Sectional Study in Hoehn and Yahr Stage 1.
abstract: BACKGROUND
  Mild cognitive impairment (MCI) in Parkinson's disease (PD) is common and confers a higher risk for developing dementia.
  
  
  METHODS
  In this cross-sectional study of MCI in PD conducted at a university hospital, a comprehensive neuropsychological battery covering five domains (attention/working memory, executive, verbal, and visual memory, language, and visuospatial) was administered to 111 nondemented PD patients in Hoehn and Yahr stage 1 and to 105 healthy matched control subjects (HC). MCI was diagnosed according to level 2 of the Movement Disorder Society Task Force criteria.
  
  
  RESULTS
  Criteria for MCI associated with PD (PD-MCI) were fulfilled by 24% of PD patients in the initial stage of the disease at the z cutoff scores of -1.5 SD in contrast to 7% of HC fulfilling criteria for MCI. Memory and visuospatial domains were the most commonly affected at -1.5 SD. PD-MCI patients mostly had a multiple-domain MCI subtype (78%). They presented a more severe bradykinesia and higher mood and apathy scores in comparison with cognitively normal PD patients. Basic motor scores predicted performance on some cognitive tests and specific cognitive-motor relationships emerged.
  
  
  CONCLUSIONS
  MCI, predominantly of a multiple-domain subtype, was quite prevalent even in the initial stage of PD.
authors.affiliation: Facultie of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Elka
authors.initials: E
authors.lastname: Stefanova
authors.forename: Ljubomir
authors.initials: L
authors.lastname: Žiropadja
authors.forename: Tanja
authors.initials: T
authors.lastname: Stojković
authors.forename: Iva
authors.initials: I
authors.lastname: Stanković
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Tomić
authors.forename: Milica
authors.initials: M
authors.lastname: Ječmenica-Lukić
authors.forename: Igor
authors.initials: I
authors.lastname: Petrović
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kostić
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000150:complications; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000175:diagnosis*; D011446:Prospective Studies; D012720:Severity of Illness Index