title: [A Case Report of Successful Chemotherapy with Tegafur/Gimeracil/Oteracil and Nab-Paclitaxel for Gastric Cancer with Chronic Renal Failure].
abstract: An 80-year-old Japanese woman with chronic renal failure was diagnosed with gastric cancer and 2 primary colon cancers. The colon cancers were treated with laparoscopic colectomy, but the gastric cancer metastasized to the liver with inoperable dissemination. After operative treatment of the colon cancers, 1 year of combination chemotherapy consisting of tegafur/gimeracil/oteracil (TS-1®) and nab-PTX was administered to treat the advanced gastric cancer. Tegafur is a well-known prodrug of 5-FU. Serum densitometry of 5-FU was performed to determine the correct dose of TS-1®. After completion of chemotherapy, no tumor was detected on gastroscopy or dynamic computed tomography. The patient was well with no recurrence 6 months after completion of chemotherapy. CDDP, CPT-11, 5-FU, PTX, and DTX are known chemotherapy agents for treating gastric cancer. Renal excretion is not involved in the metabolism of CPT-11, 5-FU, PTX, or DTX. These agents are metabolized in the liver. CPT-11 metabolism depends on individual hepatic enzymes. Therefore, we believe that nab-PTX and TS-1® are safe and effective agents for patients with chronic renal failure and advanced gastric cancer. Additionally, we also conclude that using serum densitometry of 5-FU to guide the administration of TS-1® can improve both safety and efficacy.
authors.affiliation: Dept. of Surgery, Ishikiri Seiki Hospital.
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Toru
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kurashima
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ohata
authors.forename: Masato
authors.initials: M
authors.lastname: Okawa
authors.forename: Shogo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Takahiro
authors.initials: T
authors.lastname: Uenishi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
mesh_terms: D000369:Aged, 80 and over; D000418:Albumins / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D011725:Pyridines; D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel; C104201:gimeracil