title: [The Regulatory Proteins of β-Adrenergic Receptor and Their Functions].
abstract: Vascular diseases has become a top killer of human health, and cardiovascular receptors are pivotal in the occurrence, development, prevention and treatment of cardiovascular diseases. As for the important member of G protein-coupled receptor, β-adrenergic receptor is undoubtedly a most important target of cardiovascular drugs. Being the hot spot in the cardiovascular research and application, β- adrenergic receptor blocker has been considered as the greatest breakthrough for the prevention and cure of cardiovascular disease after digitalis. The 2012 Nobel Prize in chemistry was awarded again to the researchers on β-adrenergic receptors. Extensive researchs show that β-adrenergic receptors are precisely regulated by different regulatory proteins in cells in the transduction of different physiological and pathological signaling pathways. Based on these findings, function-selective ligands recently arise in the receptor research and will be the new chance of drug discovery. In this article we reviewed the related signal pathways and functions of β-adrenergic receptor regulatory proteins.
authors.forename: Ai-ju
authors.initials: AJ
authors.lastname: Tian
authors.forename: Zi-jian
authors.initials: ZJ
authors.lastname: Li
mesh_terms: D002318:Cardiovascular Diseases; D002319:Cardiovascular System; D006801:Humans; D008024:Ligands; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D011943:Receptors, Adrenergic, beta