title: Thrombosis in vasculitic disorders-clinical manifestations, pathogenesis and management.
abstract: Inflammation and coagulation are known to affect each other in many ways. Vasculitis represents a group of disorders where blood vessels (small, medium, large or variable) are infiltrated with inflammatory cells. Accumulating evidence in the literature suggests both clinical and physiological association between vasculitis and thrombosis. Vasculitis-associated thrombosis involves arteries and veins, and a tight connection has been reported between the activity of vasculitis and the appearance of thrombosis. Pathophysiology of these relations is complex and not completely understood. While thrombophilic factors are associated with vasculitis, it remains unclear whether a true association with clinical thrombosis is present. Furthermore, several factors leading to hemostasis, endothelial injury and induction of microparticles were described as possibly accounting for thrombosis. Management of thrombosis in vasculitis patients is challenging and should be further assessed in randomized controlled studies. The current review describes clinical manifestations, pathogenesis and management of thrombosis associated with different vasculitides.
authors.affiliation: Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: Ofrat Beyar
authors.initials: OB
authors.lastname: Katz
authors.affiliation: Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel; Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel. Electronic address: b_brenner@rambam.health.gov.il.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brenner
authors.affiliation: Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel; Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
authors.forename: Netanel A
authors.initials: NA
authors.lastname: Horowitz
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001808:Blood Vessels / Q000276:immunology*; D055252:Cell-Derived Microparticles / Q000276:immunology*; D019317:Evidence-Based Medicine; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008955:Models, Cardiovascular; D018448:Models, Immunological; D013927:Thrombosis / Q000188:drug therapy* / Q000276:immunology*; D014657:Vasculitis / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents
keywords: Vasculitis; inflammation; thrombosis