title: Diagnostic accuracy of late iodine enhancement on cardiac computed tomography with a denoise filter for the evaluation of myocardial infarction.
abstract: We evaluated the image quality and diagnostic performance of late iodine enhancement (LIE) in dual-source computed tomography (DSCT) with low kilo-voltage peak (kVp) images and a denoise filter for the detection of acute myocardial infarction (AMI) in comparison with late gadolinium enhancement (LGE) magnetic resonance imaging (MRI). The Hospital Ethics Committee approved the study protocol. Before discharge, 19 patients who received percutaneous coronary intervention after AMI underwent DSCT and 1.5 T MRI. Immediately after coronary computed tomography (CT) angiography, contrast medium was administered at a slow injection rate. LIE-CT scans were acquired via dual-energy CT and reconstructed as 100-, 140-kVp, and mixed images. An iterative three-dimensional edge-preserved smoothing filter was applied to the 100-kVp images to obtain denoised 100-kVp images. The mixed, 140-kVp, 100-kVp, and denoised 100-kVp images were assessed using contrast-to-noise ratio (CNR), and their diagnostic performance in comparison with MRI and infarcted volumes were evaluated. Three hundred four segments of 19 patients were evaluated. Fifty-three segments showed LGE in MRI. The median CNR of the mixed, 140-, 100-kVp and denoised 100-kVp images was 3.49, 1.21, 3.57, and 6.08, respectively. The median CNR was significantly higher in the denoised 100-kVp images than in the other three images (P < 0.05). The denoised 100-kVp images showed the highest diagnostic accuracy and sensitivity. The percentage of myocardium in the four CT image types was significantly correlated with the respective MRI findings. The use of a denoise filter with a low-kVp image can improve CNR, sensitivity, and accuracy in LIE-CT.
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. tmatsuda.singing@gmail.com.
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsuda
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Teruhito
authors.initials: T
authors.lastname: Kido
authors.affiliation: Research and Collaboration, Siemens Japan, Shinagawa, Tokyo, Japan.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Itoh
authors.affiliation: Department of Cardiology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Saeki
authors.affiliation: Department of Cardiology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Shigemi
authors.affiliation: Department of Cardiology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan.
authors.forename: Kouki
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Radiology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kido
authors.affiliation: Department of Radiology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Aono
authors.affiliation: Department of Radiology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Department of Radiology, Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsuda
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000008:administration & dosage*; D004867:Equipment Design; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D014022:Tissue Survival; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007479:Iopamidol; D019786:Gadolinium DTPA
keywords: Acute myocardial infarction; Cardiac computed tomography; Image postprocessing; Late iodine enhancement