title: Association between polymorphisms in insulin-like growth factor-1 and risk of osteoporosis.
abstract: We conducted a case-control study to assess the relation-ship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with osteoporosis were more likely to have drinking and smoking habits and have lower bone mineral density in the L2-L4 vertebrae, femoral neck, and total hip. According to conditional regression analysis, individuals carrying the TT genotype of rs35767 had an increased risk of osteoporosis, with an adjusted odds ratio (95% confidence interval) of 2.29 (1.35-4.97). In conclusion, our results sug-gest that the TT genotype of IGF-I rs35767 was associated with an in-creased risk of osteoporosis, suggesting that this polymorphism can be used as a predictive factor for osteoporosis risk.
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, China.
authors.forename: L C
authors.initials: LC
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, China pftang301@126.com.
authors.forename: P F
authors.initials: PF
authors.lastname: Tang
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, China.
authors.forename: L H
authors.initials: LH
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010024:Osteoporosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D007334:Insulin-Like Growth Factor I