title: The safety of human papilloma virus-blockers and the risk of triggering autoimmune diseases.
abstract: BACKGROUND
  With the safety of human papilloma virus vaccine (HPVv) being questioned, this article aims to assess the risks and benefits of the commercially available HPVv. Within the last decade, two vaccines (Gardasil and Cervarix) have been put on the market to prevent infection with the most oncogenic HPV subtypes. Both vaccines contain aluminum adjuvants that are meant to cause a hyper stimulated immune response to prevent HPV infection.
  
  
  METHODS
  The purpose of this paper is to consider the safety of these two vaccines based on the data from the U.S. Vaccine Adverse Event Reporting System (VAERS) and case reports.
  
  
  CONCLUSIONS
  The current HPVv are both effective and generally safe. However, it should be noted that autoimmune side effects have been reported in several studies. Further research should be done to understand the relationship between HPVv and autoimmunity.
authors.affiliation: a 1 The Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center , Tel-Hashomer 52621, Israel +972 3 5302652 ; +972 3 5352855 ; shoenfel@post.tau.ac.il.
authors.forename: Britain
authors.initials: B
authors.lastname: Baker
authors.forename: Luísa
authors.initials: L
authors.lastname: Eça Guimarães
authors.forename: Lucija
authors.initials: L
authors.lastname: Tomljenovic
authors.forename: Nancy
authors.initials: N
authors.lastname: Agmon-Levin
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry; D017607:Aluminum Compounds / Q000737:chemistry / Q000276:immunology; D000818:Animals; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D030361:Papillomavirus Infections / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000276:Adjuvants, Immunologic; D017607:Aluminum Compounds; D053918:Papillomavirus Vaccines
keywords: adjuvant; aluminum; autoimmune/inflammatory syndrome induced by adjuvants; autoimmunity; guillain barré syndrome; human papilloma virus; postural orthostatic tachycardia syndrome; premature ovarian failure; vaccines