title: Rheological and textural properties of microemulsion-based polymer gels with indomethacin.
abstract: In this paper, we present novel microemulsion (ME)-based semisolid polymer gels designed for topical administration of poorly water soluble non-steroidal anti-inflammatory drugs. Indomethacin (IND) was used as a model compound. The ME consisted of castor oil, water, Tween®80 as a surfactant and ethanol as cosurfactant. To obtain the desired consistency of the formulations Carbopol®960 was applied as a thickening agent. The aim of the study was to analyze in detail the mechanical properties of the obtained systems, with special attention paid to the features crucial for topical application. The rheological and textural experiments performed for samples with and without the incorporated drug clearly indicate that flow characteristics, viscoelastic properties and texture profiles were affected by the presence of IND. Novel semisolid formulations with IND described for the first time in this paper can be considered as an alternative for commercially available conventional topical dosage forms.
authors.affiliation: a Department of Pharmaceutical Technology , Poznan University of Medical Sciences , Poznań , Poland and.
authors.forename: Anna
authors.initials: A
authors.lastname: Froelich
authors.affiliation: a Department of Pharmaceutical Technology , Poznan University of Medical Sciences , Poznań , Poland and.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Osmałek
authors.affiliation: a Department of Pharmaceutical Technology , Poznan University of Medical Sciences , Poznań , Poland and.
authors.forename: Paweł
authors.initials: P
authors.lastname: Kunstman
authors.affiliation: a Department of Pharmaceutical Technology , Poznan University of Medical Sciences , Poznań , Poland and.
authors.forename: Rafał
authors.initials: R
authors.lastname: Roszak
authors.affiliation: b Department of Biotechnology and Food Microbiology , Poznan University of Life Sciences , Poznań , Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Białas
mesh_terms: D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D002368:Castor Oil / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004655:Emulsions / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D007213:Indomethacin / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry; D012212:Rheology; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004655:Emulsions; D005079:Excipients; D005782:Gels; D011108:Polymers; D011136:Polysorbates; D013501:Surface-Active Agents; D014867:Water; D000431:Ethanol; D002368:Castor Oil; D007213:Indomethacin
keywords: Drug delivery; microemulsions; non-steroidal anti-inflammatory drugs; rheology; texture profile analysis