title: The molecules that mediate sensory transduction in the mammalian inner ear.
abstract: Years of searching and researching have finally yielded a few leads in the quest to identify molecules required for mechanosensory transduction in the mammalian inner ear. Studies of human and mouse genetics have raised the profile of several molecules that are crucial for the function sensory hair cells. Follow up studies have begun to define the molecular function and biochemical interactions of several key proteins. These studies have exposed a sensory transduction apparatus that is more complex than originally envisioned and have reinvigorated the search for additional molecular components required for normal inner ear function.
authors.affiliation: Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.
authors.forename: Bifeng
authors.initials: B
authors.lastname: Pan
authors.affiliation: Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States. Electronic address: jeffrey.holt@childrens.harvard.edu.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Holt
mesh_terms: D000818:Animals; D007758:Ear, Inner / Q000166:cytology*; D006309:Hearing / Q000235:genetics / Q000502:physiology*; D006801:Humans; D059373:Mastodynia; D011984:Sensory Receptor Cells / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*