title: Anti-Resorptive Functions of Poly(ethylene sodium phosphate) on Human Osteoclasts.
abstract: Osteoporosis involves hyperactive osteoclasts. A large number of current drugs result in side effects affecting their efficacy in the clinic. Polyphosphoesters are unique polymeric biomaterials because of their biocompatibility, biodegradability, and bone affinity. We studied the viability and ability of human osteoclasts to resorb bone when dosed with poly(ethylene sodium phosphate) (PEP·Na). This did not trigger any change in osteoblast cell viability, however the polymer diminished human osteoclasts and their ability to resorb bone at concentrations as low as 10(-4) m · mL(-1). This is the first report to validate the possibility of using polyphosphoesters for selective inhibition of human osteoclast functions, indicating its potential to be used as an effective polymer prodrug for treatment of osteoporosis.
authors.affiliation: Department of Chemistry, Polymer Chemistry, Uppsala University, Ångström Laboratory, S-75121 Uppsala, Sweden.
authors.forename: Sujit
authors.initials: S
authors.lastname: Kootala
authors.affiliation: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tokunaga
authors.affiliation: Department of Chemistry, Polymer Chemistry, Uppsala University, Ångström Laboratory, S-75121 Uppsala, Sweden. jons.hilborn@kemi.uu.se.
authors.forename: Jöns
authors.initials: J
authors.lastname: Hilborn
authors.affiliation: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan. yasu.bmt@kansai-u.ac.jp.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Iwasaki
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D051379:Mice; D010010:Osteoclasts / Q000378:metabolism* / Q000473:pathology; D010024:Osteoporosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D011095:Polyethylenes / Q000494:pharmacology*
chemical_list: D011095:Polyethylenes; C000608163:poly(ethylene sodium phosphate)
keywords: biocompatibility; bone therapy; osteoblast; osteoclast; polyphosphoesters