title: No association between vitamin D and atopy, asthma, lung function or atopic dermatitis: a prospective study in adults.
abstract: Studies suggest that vitamin D may be involved in the pathogenesis of allergic disorders, asthma and decreased lung function. However, results are inconsistent and only few prospective studies have examined adults. The purpose of this study was to investigate the association of serum 25-hydroxy vitamin D (s25(OH)D) with atopy, atopic dermatitis (AD), asthma, wheezing and impaired lung function in a prospective study of Danish adults. A random sample of 3471 persons was examined in 2006-2008. Of these, 2308 were re-examined 5 years later. s25(OH)D and specific IgE against four common inhalant allergens were measured by standard procedures. Wheezing, asthma and AD were assessed from questionnaires and lung function was measured by spirometry. We found no statistically significant associations between s25(OH)D and prevalence or incidence of atopy, AD, asthma or wheezing. Associations with lung function were inconsistent. We conclude that vitamin D status does not influence these conditions in adults.
authors.affiliation: Research Centre for Prevention and Health, The Capital Region of Denmark, Rigshospitalet, Glostrup, Denmark.
authors.forename: B H
authors.initials: BH
authors.lastname: Thuesen
authors.affiliation: Research Centre for Prevention and Health, The Capital Region of Denmark, Rigshospitalet, Glostrup, Denmark.|Department of Dermato-Allergology, The National Allergy Research Centre, Copenhagen University Hospital Gentofte, Gentofte, Denmark.
authors.forename: N G
authors.initials: NG
authors.lastname: Heede
authors.affiliation: Research Centre for Prevention and Health, The Capital Region of Denmark, Rigshospitalet, Glostrup, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Tang
authors.affiliation: Research Centre for Prevention and Health, The Capital Region of Denmark, Rigshospitalet, Glostrup, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Skaaby
authors.affiliation: Department of Dermato-Allergology, The National Allergy Research Centre, Copenhagen University Hospital Gentofte, Gentofte, Denmark.
authors.forename: J P
authors.initials: JP
authors.lastname: Thyssen
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Friedrich
authors.affiliation: Research Centre for Prevention and Health, The Capital Region of Denmark, Rigshospitalet, Glostrup, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.|Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Linneberg
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood* / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D003876:Dermatitis, Atopic / Q000097:blood* / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D000091344:Filaggrin Proteins; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007381:Intermediate Filament Proteins / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D062486:Public Health Surveillance; D012042:Registries; D012129:Respiratory Function Tests; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D014807:Vitamin D; D007073:Immunoglobulin E; C104450:25-hydroxyvitamin D
keywords: IgE; asthma; atopic dermatitis; epidemiology; prevention