title: Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis.
abstract: In this study we examined the role of fumaric acid esters (FAE) in a spontaneous and chronic animal model, the opticospinal EAE (OSE). Preventive treatment of dimethylfumarate (DMF) promotes onset of disease in animals treated with high dose DMF. This group also exhibited a significantly exacerbated disease course in a therapeutic treatment as compared to the low dose DMF approach, where less demyelination, macrophage infiltration, and increased Nrf2 expression in the spinal cord were observed. We conclude that low dose DMF treatment is effective in the therapy of the spontaneous opticospinal EAE model and mediates neuroprotective effects via the oxidative stress response pathway.
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany. Electronic address: seray.demir@rub.de.
authors.forename: Seray
authors.initials: S
authors.lastname: Demir
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Heckers
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany.
authors.forename: Xiomara
authors.initials: X
authors.lastname: Pedreiturria
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Hess
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany.
authors.forename: Anne-Kathrin
authors.initials: AK
authors.lastname: Trampe
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany.
authors.forename: Andrew
authors.initials: A
authors.lastname: Chan
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Gold
mesh_terms: D000818:Animals; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D004952:Esters; D005650:Fumarates / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D004952:Esters; D005650:Fumarates
keywords: Dimethylfumarate; Nrf2; OSE