title: Inhibition of Advanced Glycation Endproduct Formation by Lotus Seedpod Oligomeric Procyanidins through RAGE-MAPK Signaling and NF-κB Activation in High-Fat-Diet Rats.
abstract: This study investigated the protective properties of lotus seedpod oligomeric procyanidins (LSOPC) against nonalcoholic fatty liver disease (NAFLD) and its underlying mechanism. Sprague-Dawley (SD) male rats were fed a basic diet, a high-fat diet (HFD), or HFD plus 0.2 or 0.5% (w/w) LSOPC for 12 weeks. Administration of LSOPC markedly reduced serum and hepatic biochemical parameters and protein expression of advanced glycation endproducts (AGEs). Additionally, 0.5% (w/w) LSOPC treatment remarkably reversed the increasing tendency of receptor of advanced glycation endproduct (RAGE) to normal level. Furthermore, dietary LSOPC significantly decreased the protein levels of mitogen-activated protein kinases (MAPK) and nuclear factor-kappa B (NF-κB) and down-regulated genes involved in pro-inflammatory cytokines and adhesion molecules. Taken together, these findings demonstrate that LSOPC may protect obese rats with long-term HFD-induced NAFLD against RAGE-MAPK-NF-κB signaling suppression.
authors.affiliation: †Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.affiliation: §College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, Hubei 430070, People's Republic of China.
authors.forename: Shuyi
authors.initials: S
authors.lastname: Li
authors.affiliation: †Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Li
authors.affiliation: †Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Sui
authors.affiliation: †Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: †Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Dong
authors.affiliation: †Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
authors.forename: Bijun
authors.initials: B
authors.lastname: Xie
authors.affiliation: †Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
authors.forename: Zhida
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000818:Animals; D044946:Biflavonoids / Q000008:administration & dosage* / Q000737:chemistry; D002392:Catechin / Q000008:administration & dosage* / Q000737:chemistry; D059305:Diet, High-Fat / Q000009:adverse effects; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D000070116:Lotus / Q000737:chemistry*; D008297:Male; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D044945:Proanthocyanidins / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics / Q000378:metabolism*; D012639:Seeds / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects
chemical_list: C000593874:Ager protein, rat; D044946:Biflavonoids; D017127:Glycation End Products, Advanced; D016328:NF-kappa B; D010936:Plant Extracts; D044945:Proanthocyanidins; D000067759:Receptor for Advanced Glycation End Products; C017674:procyanidin; D002392:Catechin; D020928:Mitogen-Activated Protein Kinases
keywords: advanced glycation endproducts; lotus seedpod oligomeric procyanidins; nonalcoholic fatty liver disease; nuclear factor-kappa B; receptor of advanced glycation endproduct