title: Brain Metastases from Solid Tumors: an Institutional Study from South India.
abstract: BACKGROUND
  Brain metastases are the most common intra-cranial neoplasms. The incidence is on a rise due to advanced imaging techniques.
  
  
  OBJECTIVE
  The objective of the study was to analyse the clinical and demographic profile of patients with brain metastases from primary solid tumors.
  
  
  METHODS
  This is a retrospective single institutional study covering 130 consecutive patients with brain metastases from January 2007 to August 2014.
  
  
  RESULTS
  Some 64.6% of the patients were females. The majority were in the sixth decade of life. The site of the primary tumor was the lungs in 50.8% of the cases. The overall median time from the diagnosis of the primary malignancy to detection of brain metastases was 21.4 months. Survival was found to be significantly improved in patients with solitary brain lesions when compared to patients with multiple brain metastases, and in patients undergoing surgical excision with or without cranial irradiation when compared to whole brain irradiation alone. The majority of the cases belonged to the recursive partitioning analysis class II group. Whole brain radiation therapy was delivered to 79% of the patients.
  
  
  CONCLUSIONS
  Most of the patients with brain metastases in the study belonged to recursive partitioning analysis classes II or III, and hence had poor prognosis. Most of the patients in the Indian context either do not satisfy the indications for surgical excision or are incapable of bearing the high cost associated with stereotactic radiosurgery. Treatment should be tailored on an individual basis to all these patients.
authors.affiliation: Department of Radiotherapy, GSL Cancer Hospital, GSL Medical College, Rajahmundry, India E-mail : drsaptarshi10@gmail.com.
authors.forename: Saptarshi
authors.initials: S
authors.lastname: Ghosh
authors.forename: Pamidimukkala Brahmananda
authors.initials: PB
authors.lastname: Rao
mesh_terms: D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D016371:Cranial Irradiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate