title: Amorphous metal-organic frameworks for drug delivery.
abstract: We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.
authors.affiliation: Department of Chemical Engineering & Biotechnology, University of Cambridge, CB2 3RA Cambridge, UK. df334@cam.ac.uk.
authors.forename: Claudia
authors.initials: C
authors.lastname: Orellana-Tavra
authors.forename: Emma F
authors.initials: EF
authors.lastname: Baxter
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Bennett
authors.forename: Nigel K H
authors.initials: NK
authors.lastname: Slater
authors.forename: Anthony K
authors.initials: AK
authors.lastname: Cheetham
authors.forename: David
authors.initials: D
authors.lastname: Fairen-Jimenez
mesh_terms: D056831:Coordination Complexes / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D005452:Fluoresceins / Q000008:administration & dosage / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D015040:Zirconium / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D005452:Fluoresceins; D015040:Zirconium; C007740:fluorexon