title: Nanomedicines Targeting the Tumor Microenvironment.
abstract: We review recent progress in cancer nanomedicine to overcome the delivery barriers in tumor microenvironment, including the understanding in the nanomedicine delivery process, stimulus-responsive delivery, and several new strategies to normalize tumor microenvironment. The application of nanomedicine in cancer immunotherapy, a renewed cancer therapy by recent breakthrough, is also highlighted.
authors.affiliation: From the *Koch Institute, Massachusetts Institute of Technology, Cambridge; and †Laboratory for Biomaterials and Drug Delivery, Division of Critical Care Medicine, Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA.
authors.forename: Rong
authors.initials: R
authors.lastname: Tong
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004337:Drug Carriers / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D007167:Immunotherapy; D050997:Nanomedicine; D053758:Nanoparticles / Q000627:therapeutic use*; D049329:Nanostructures / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers