title: Lack of associations between XPC polymorphisms and colorectal cancer: a meta-analysis.
abstract: OBJECTIVE
  The relationships between XPC polymorphisms (Lys939Gln and Ala499Val) and the susceptibility to colorectal cancer (CRC) have been studied by several researchers, but the results were inconclusive. To get a more precise estimation of the relationships, we conducted this meta-analysis.
  
  
  METHODS
  A total of 9 case-control studies, including 3679 cases and 33551 controls for Lys939Gln and 1327 cases and 30438 controls for Ala499Val, were selected. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the additive, dominant and recessive models.
  
  
  RESULTS
  When all the studies were pooled into the meta-analysis, no evidence showing a significant association between XPC polymorphisms and CRC risk was noticed. In the subgroup analysis by ethnicity and study design, no significant association was also found.
  
  
  CONCLUSIONS
  In conclusion, this meta-analysis indicated that the XPC polymorphisms were not risk factors for the development of CRC.
authors.affiliation: Department of Colorectal Surgery, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.
authors.forename: Guiyu
authors.initials: G
authors.lastname: Wang
authors.forename: Haiming
authors.initials: H
authors.lastname: Sun
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.forename: Yinggang
authors.initials: Y
authors.lastname: Chen
authors.forename: Qingchao
authors.initials: Q
authors.lastname: Tang
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiang
authors.forename: Xishan
authors.initials: X
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D004268:DNA-Binding Proteins; C086984:XPC protein, human