title: Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
abstract: The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.|German Center for Diabetes Research (DZD), Neuherberg, Germany.
authors.forename: Martin Hrabě
authors.initials: MH
authors.lastname: de Angelis
authors.affiliation: Department of Statistics, University of Oxford, Oxford, UK.
authors.forename: George
authors.initials: G
authors.lastname: Nicholson
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Selloum
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Jacqui
authors.initials: J
authors.lastname: White
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Hugh
authors.initials: H
authors.lastname: Morgan
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Ramiro
authors.initials: R
authors.lastname: Ramirez-Solis
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Tania
authors.initials: T
authors.lastname: Sorg
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Wells
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Fuchs
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Fray
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: David J
authors.initials: DJ
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authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Niels C
authors.initials: NC
authors.lastname: Adams
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
authors.forename: Thure
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authors.lastname: Adler
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
authors.forename: Antonio
authors.initials: A
authors.lastname: Aguilar-Pimentel
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Dalila
authors.initials: D
authors.lastname: Ali-Hadji
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
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authors.initials: G
authors.lastname: Amann
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: André
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Atkins
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Aurelie
authors.initials: A
authors.lastname: Auburtin
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Abdel
authors.initials: A
authors.lastname: Ayadi
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Becker
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.
authors.forename: Lore
authors.initials: L
authors.lastname: Becker
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Bedu
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Raffi
authors.initials: R
authors.lastname: Bekeredjian
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Birling
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Andrew
authors.initials: A
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authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
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authors.initials: J
authors.lastname: Bottomley
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Mike
authors.initials: M
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authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Véronique
authors.initials: V
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authors.affiliation: Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
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authors.initials: DH
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authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: James N
authors.initials: JN
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authors.affiliation: Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Calzada-Wack
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
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authors.initials: H
authors.lastname: Cater
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Champy
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Charles
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Claire
authors.initials: C
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authors.affiliation: Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
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authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
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authors.initials: GF
authors.lastname: Codner
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
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authors.initials: R
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authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Roger
authors.initials: R
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authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Dalloneau
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: André
authors.initials: A
authors.lastname: Dierich
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Armida
authors.initials: A
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authors.affiliation: Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
authors.forename: Brendan
authors.initials: B
authors.lastname: Doe
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Arnaud
authors.initials: A
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authors.affiliation: Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Eickelberg
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
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authors.initials: CT
authors.lastname: Esapa
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Lahcen
authors.initials: L
authors.lastname: El Fertak
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
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authors.initials: T
authors.lastname: Feigel
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
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authors.initials: I
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authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Jeanne
authors.initials: J
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authors.affiliation: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Jack
authors.initials: J
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authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
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authors.affiliation: Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
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authors.initials: A
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authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
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authors.initials: L
authors.lastname: Garrett
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Hilary
authors.initials: H
authors.lastname: Gates
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Gerdin
authors.affiliation: Department of Computer Science, University of Aberystwyth, UK.
authors.forename: George
authors.initials: G
authors.lastname: Gkoutos
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
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authors.initials: S
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authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Glasl
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Goetz
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Isabelle Goncalves
authors.initials: IG
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authors.affiliation: Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
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authors.initials: A
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authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Graw
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Guimond
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hans
authors.affiliation: Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
authors.forename: Geoff
authors.initials: G
authors.lastname: Hicks
authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Sabine M
authors.initials: SM
authors.lastname: Hölter
authors.affiliation: Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.
authors.forename: Heinz
authors.initials: H
authors.lastname: Höfler
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: John M
authors.initials: JM
authors.lastname: Hancock
authors.affiliation: Computational Bioscience Research Center, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia.
authors.forename: Robert
authors.initials: R
authors.lastname: Hoehndorf
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Tertius
authors.initials: T
authors.lastname: Hough
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Houghton
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Hurt
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Ivandic
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Hughes
authors.initials: H
authors.lastname: Jacobs
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Jacquot
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
authors.forename: Nora
authors.initials: N
authors.lastname: Jones
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Natasha A
authors.initials: NA
authors.lastname: Karp
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Katus
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Sharon
authors.initials: S
authors.lastname: Kitchen
authors.affiliation: Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Klein-Rodewald
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Klingenspor
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Klopstock
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Lalanne
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Leblanc
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Lengger
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Elise
authors.initials: E
authors.lastname: le Marchand
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Tonia
authors.initials: T
authors.lastname: Ludwig
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Lux
authors.affiliation: Toronto Centre for Phenogenomics, Toronto, Canada.|The Hospital for Sick Children, Toronto, Canada.
authors.forename: Colin
authors.initials: C
authors.lastname: McKerlie
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Maier
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mandel
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Marschall
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Manuel
authors.initials: M
authors.lastname: Mark
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: David G
authors.initials: DG
authors.lastname: Melvin
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Hamid
authors.initials: H
authors.lastname: Meziane
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Kateryna
authors.initials: K
authors.lastname: Micklich
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Mittelhauser
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Monassier
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: David
authors.initials: D
authors.lastname: Moulaert
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Muller
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Beatrix
authors.initials: B
authors.lastname: Naton
authors.affiliation: Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Neff
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Nolan
authors.affiliation: The Hospital for Sick Children, Toronto, Canada.
authors.forename: Lauryl Mj
authors.initials: LM
authors.lastname: Nutter
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Ollert
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Pavlovic
authors.affiliation: Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Pellegata
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Peter
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Petit-Demoulière
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Amanda
authors.initials: A
authors.lastname: Pickard
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Christine
authors.initials: C
authors.lastname: Podrini
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Potter
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Pouilly
authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Puk
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: David
authors.initials: D
authors.lastname: Richardson
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Rousseau
authors.affiliation: Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Leticia
authors.initials: L
authors.lastname: Quintanilla-Fend
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Quwailid
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany.
authors.forename: Ildiko
authors.initials: I
authors.lastname: Racz
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Rathkolb
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Riet
authors.affiliation: The Hospital for Sick Children, Toronto, Canada.
authors.forename: Janet
authors.initials: J
authors.lastname: Rossant
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Roux
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Rozman
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Ed
authors.initials: E
authors.lastname: Ryder
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Salisbury
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Luis
authors.initials: L
authors.lastname: Santos
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Schäble
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Schiller
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Schrewe
authors.affiliation: Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Schulz
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Steinkamp
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Simon
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Stewart
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Stöger
authors.affiliation: Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Stöger
authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Minxuan
authors.initials: M
authors.lastname: Sun
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: David
authors.initials: D
authors.lastname: Sunter
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Lydia
authors.initials: L
authors.lastname: Teboul
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Tilly
authors.affiliation: Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
authors.forename: Glauco P
authors.initials: GP
authors.lastname: Tocchini-Valentini
authors.affiliation: Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Monica
authors.initials: M
authors.lastname: Tost
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Irina
authors.initials: I
authors.lastname: Treise
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Vasseur
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Velot
authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Vogt-Weisenhorn
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Wagner
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Alison
authors.initials: A
authors.lastname: Walling
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Weber
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Olivia
authors.initials: O
authors.lastname: Wendling
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Henrik
authors.initials: H
authors.lastname: Westerberg
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Monja
authors.initials: M
authors.lastname: Willershäuser
authors.affiliation: Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.|German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Eckhard
authors.initials: E
authors.lastname: Wolf
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Wolter
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Joe
authors.initials: J
authors.lastname: Wood
authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.|Max-Planck-Institute of Psychiatry, Munich, Germany.|Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wurst
authors.affiliation: Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Ali Önder
authors.initials: AÖ
authors.lastname: Yildirim
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Ramona
authors.initials: R
authors.lastname: Zeh
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.|Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimmer
authors.affiliation: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Zimprich
authors.affiliation: Department of Statistics, University of Oxford, Oxford, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Holmes
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Karen P
authors.initials: KP
authors.lastname: Steel
authors.affiliation: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.|Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.|Centre National de la Recherche Scientifique, Illkirch, France.|Institut National de la Santé et de la Recherche Médicale, Illkirch, France.|Université de Strasbourg, Illkirch, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Herault
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gailus-Durner
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Mallon
authors.affiliation: MRC Harwell, Medical Research Council, Harwell, UK.
authors.forename: Steve Dm
authors.initials: SD
authors.lastname: Brown
mesh_terms: D000818:Animals; D005260:Female; D056726:Genetic Association Studies; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D058977:Molecular Sequence Annotation; D009154:Mutation; D010641:Phenotype