title: [In vitro antifungal susceptibility profile of Scopulariopsis brevicaulis isolated from onychomycosis].
abstract: We studied the in vitro antifungal activity profile of amorolfine (AMR), bifonazole (BFZ), clotrimazole (CLZ), econazole (ECZ), fluconazole (FNZ), itraconazole (ITZ), ketoconazole (KTZ), miconazole (MNZ), oxiconazole (OXZ), tioconazole (TCZ) and terbinafine (TRB) against 26 clinical isolates of Scopulariopsis brevicaulis from patients with onychomycosis by means of an standardized microdilution method. Although this opportunistic filamentous fungi was reported as resistant to several broad-spectrum antifungals agents, obtained data shows a better fungistatic in vitro activity of AMR, OXZ and TRB (0.08, 0.3, and 0.35 mg/L, respectively) in comparison to that of CLZ (0.47 mg/L), ECZ (1.48 mg/L), MNZ (1.56 mg/L, BFZ (2.8 mg/L), TCZ (3.33 mg/L), KTZ (3.73 mg/L). FNZ (178.47 mg/L) and ITZ (4.7 mg/L) showed a reduced in vitro antifungal activity against S. brevicaulis. Obtained MICs show the low in vitro antifungal susceptibility of S. brevicaulis to topical drugs for onychomycosis management, with exceptions (AMR, OZX and TRB).
authors.affiliation: Alfonso Javier Carrillo-Muñoz. Apdo. Postal 10178. E-08080 Barcelona. Spain. acarrillo@aciam.es.
authors.forename: Alfonso Javier
authors.initials: AJ
authors.lastname: Carrillo-Muñoz
authors.forename: Cristina
authors.initials: C
authors.lastname: Tur-Tur
authors.forename: Délia
authors.initials: D
authors.lastname: Cárdenes
authors.forename: Florencia
authors.initials: F
authors.lastname: Rojas
authors.forename: Gustavo
authors.initials: G
authors.lastname: Giusiano
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D014009:Onychomycosis / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents