title: Ellagic acid modulates sodium valproate induced reproductive toxicity in male Wistar rats.
abstract: This study evaluated the protective effect of ellagic acid on sodium valproate-induced sperm abnormalities in male Wistar rats. A total of 30 rats were grouped into five groups, each having 6 animals. Vehicle, sodium valproate (400 mg/kg) and ellagic acid (10, 25, 50 mg/kg) were given orally from day 1 to day 7, and ellagic acid was continued for 3 more days. On day fourteen, animals were sacrificed and the different parameters were recorded. There was a significant decrease in the sperm count and sperm motility after the exposure to sodium valproate. The percentage of abnormal sperms increased in a dose-dependent manner. The histopathological examination revealed that sodium valproate had caused degeneration and desquamation of germinal cells in the epithelium and also showed a decrease in the Johnsen's scoring. Ellagic acid provided partial protection at the doses of 10 and 25 mg/kg and complete protection at 50 mg/kg, against sodium valproate induced testicular and spermatozoal damage.
authors.forename: Chandrashekaran
authors.initials: C
authors.lastname: Girish
authors.forename: Oommen
authors.initials: O
authors.lastname: Shweta
authors.forename: Vishnu
authors.initials: V
authors.lastname: Raj
authors.forename: Sadasivam
authors.initials: S
authors.lastname: Balakrishnan
authors.forename: Renu G'boy
authors.initials: RG
authors.lastname: Varghese
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004610:Ellagic Acid / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D014635:Valproic Acid / Q000633:toxicity*
chemical_list: D004610:Ellagic Acid; D014635:Valproic Acid