title: Comparison of salivary levels of mucin and amylase and their relation with clinical parameters obtained from patients with aggressive and chronic periodontal disease.
abstract: OBJECTIVE
  Salivary mucin and amylase levels are increased in patients with chronic periodontitis (CP). Due to the fact that aggressive periodontitis (AgP) not only differs from chronic periodontitis in terms of its clinical manifestation, the aim of this study was to compare salivary mucin and amylase levels and their relation to the clinical parameters of patients with aggressive periodontitis with that of patients with chronic periodontitis.
  
  
  METHODS
  Eighty subjects were divided into two groups: 20 patients with AgP and their 20 matched controls and 20 patients with CP and their 20 matched controls, based on clinical attachment loss (CAL), probing pocket depth (PPD) and bleeding on probing (BOP). Whole unstimulated saliva was obtained and mucin, amylase and protein were determined by colorimetric methods. Pearson's correlation analysis was used to determine the relationship between salivary mucin, amylase and protein levels and the clinical parameters.
  
  
  RESULTS
  Salivary mucin, amylase and protein levels were increased in patients with AgP and CP but there were no differences between them or between control groups. Pearson's correlation analysis, determined in the entire subjects studied, showed a positive and significant correlation of mucin, amylase and proteins with CAL and PPD and a negative correlation with the flow rate. When Pearson's correlation analysis was carried out in each group separately, Fisher's z transformation showed no significant difference between both groups.
  
  
  CONCLUSIONS
  Comparison of the salivary levels of mucin, amylase and protein and their relationship with clinical parameters of AgP patients with that of CP patients revealed no differences between both groups.
authors.affiliation: Department of Pharmacology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Andrea Beatriz
authors.initials: AB
authors.lastname: Acquier
authors.affiliation: Department of Pharmacology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Alejandra Karina De Couto
authors.initials: AK
authors.lastname: Pita
authors.affiliation: Department of Pharmacology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Lucila
authors.initials: L
authors.lastname: Busch
authors.affiliation: Department of Biophysics, Faculty of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Gabriel Antonio
authors.initials: GA
authors.lastname: Sánchez
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000378:metabolism*; D000681:Amylases / Q000032:analysis*; D000704:Analysis of Variance; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009077:Mucins / Q000032:analysis*; D017622:Periodontal Attachment Loss; D010512:Periodontal Index; D012016:Reference Values; D012463:Saliva / Q000737:chemistry*; D012472:Salivation; D012636:Secretory Rate; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D009077:Mucins; D000681:Amylases