title: Quantitative comparison of topical aluminum salt solution efficacy for management of sweating: a randomized, controlled trial.
abstract: BACKGROUND
  There is a lack of studies objectively comparing the efficacy of topical antiperspirants in reducing sweat.
  
  
  OBJECTIVE
  To objectively and quantitatively compare the efficacy of two aluminum salt solutions for the reduction of induced sweating.
  
  
  METHODS
  A subject, rater, and statistician-blinded, randomized, controlled trial. Nineteen subjects were exposed to a standardized heat challenge for 3 h. Topical agent A (20% aluminum chloride hexahydrate) was randomized to either axilla, and topical agent B (1% aluminum acetate) assigned to the contralateral side. A sauna suit induced sweating during three 30-min heat intervals: (1) with no study agents (pre); (2) with both study agents, one on each side; and (3) after the agents were washed off (post). Sweat levels were measured by securing Whatman(®) filter paper to each axilla and measuring the paper weight after each heat interval. The difference in paper weight following each heat interval between Study Agent A and Study Agent B was measured by a gravimetric scale.
  
  
  RESULTS
  Topical agent A had a significantly greater effect at reducing axillary sweating than B (P = 0.0002).
  
  
  CONCLUSIONS
  In a sweating simulation, 20% aluminum chloride hexahydrate quantitatively and objectively appeared to reduce sweat more effectively than 1% aluminum acetate.
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Jillian H
authors.initials: JH
authors.lastname: Swary
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Dennis P
authors.initials: DP
authors.lastname: West
authors.affiliation: Department of Dermatology, University of Oklahoma, Norman, OK, USA.
authors.forename: Rohit
authors.initials: R
authors.lastname: Kakar
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Ortiz
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Schaeffer
authors.affiliation: Emory University School of Medicine, Atlanta, GA, USA.|Baptist Health South Florida, Miami, FL, USA.
authors.forename: Emir
authors.initials: E
authors.lastname: Veledar
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.|Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.|Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Murad
authors.initials: M
authors.lastname: Alam
mesh_terms: D000085:Acetates / Q000008:administration & dosage*; D000279:Administration, Cutaneous; D000328:Adult; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage*; D051520:Antiperspirants; D001365:Axilla; D002712:Chlorides / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D013546:Sweating / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000085:Acetates; D017607:Aluminum Compounds; D051520:Antiperspirants; D002712:Chlorides; D000077410:Aluminum Chloride; C013396:aluminum acetate
keywords: randomized controlled trial; sweat; topical agents