title: Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation.
abstract: Antibody affinity maturation involves selective survival of high affinity B cells and is thought to require the germinal center (GC) microenvironment. In this issue of Immunity, Di Niro et al. (2015) challenge this view, showing that low affinity B cells initiate Salmonella responses and affinity mature outside of GCs.
authors.affiliation: Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Higdon
authors.affiliation: Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cancro@mail.med.upenn.edu.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Cancro
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D060966:Clonal Selection, Antigen-Mediated / Q000276:immunology*; D018858:Germinal Center / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*; D027041:Somatic Hypermutation, Immunoglobulin / Q000276:immunology*