title: Propylthiouracil induced pulmonary-renal syndrome: a case report.
abstract: Propylthiouracil (PTU) is known to induce antineutrophil cytoplasmatic antibody (ANCA) seropositivity; however, small vessel vasculitis (SVV) with pulmonary and renal involvement is rare. We present the case of an 81-year-old woman on PTU treatment due to toxic nodular goitre who developed alveolar hemorrhage and rapidly progressive glomerulonephritis. The authors highlight the importance of early recognising drug-induced pulmonary-renal syndrome (PRS) in order to avoid unnecessary tests, a delay in the diagnosis and evolution to end-stage kidney disease or life-threatening conditions.
authors.forename: M
authors.initials: M
authors.lastname: Boattini
authors.forename: A
authors.initials: A
authors.lastname: Rodrigues
authors.forename: P
authors.initials: P
authors.lastname: Nascimento
authors.forename: K C
authors.initials: KC
authors.lastname: Luz
authors.forename: S
authors.initials: S
authors.lastname: Castelo Branco
authors.forename: N
authors.initials: N
authors.lastname: Rodrigues
authors.forename: P
authors.initials: P
authors.lastname: Cachado
authors.forename: T
authors.initials: T
authors.lastname: Garcia
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced*; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D011441:Propylthiouracil / Q000009:adverse effects*
chemical_list: D011441:Propylthiouracil