title: Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target.
abstract: The authors established that cigarette smoke increases airway epithelial platelet activating factor receptor (PAFr) expression and that PAFr is markedly up-regulated in the lungs of chronic obstructive pulmonary disease (COPD) patients. Crucially, PAFr is used by the two key bacterial species involved in chronic infection and acute exacerbations in COPD, that is, Streptococcus pneumoniae and Haemophilus influenzae, as a receptor for lung epithelial colonization. The cognate adhesin of PAFr, phosphorylcholine (ChoP), in the cell wall of these bacterial species may be a key effector that underpins host colonization. In this review, the authors evaluate the respective roles of PAFr and ChoP in the natural history of COPD and discuss the potential of the airway epithelial PAFr-bacterial ChoP interaction as a selective anti-infective target in COPD therapeutics.
authors.affiliation: NHMRC Centre of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia.
authors.forename: Shakti Dhar
authors.initials: SD
authors.lastname: Shukla
authors.forename: Sukhwinder Singh
authors.initials: SS
authors.lastname: Sohal
authors.forename: Ronan F
authors.initials: RF
authors.lastname: O'Toole
authors.forename: Mathew Suji
authors.initials: MS
authors.lastname: Eapen
authors.forename: Eugene Haydn
authors.initials: EH
authors.lastname: Walters
mesh_terms: D001424:Bacterial Infections / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D010980:Platelet Membrane Glycoproteins; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor
keywords: PAFr antagonist; airway epithelium; bacterial adhesion; inhaled corticosteroids; platelet activating factor receptor; pneumococcal infections