title: Benzylated and prenylated flavonoids from the root barks of Cudrania tricuspidata with pancreatic lipase inhibitory activity.
abstract: A new benzylated and prenylated flavonone, cudracuspiflavanone A (17) were isolated from the roots of Cudrania tricuspidata (Moraceae), together with two chromones (1-2) and fourteen flavonoids (3-16). The structures of isolated compounds were determined on the basis of spectroscopic analysis. The absolute configuration was also defined by CD analysis. Among the isolated compounds, compounds 14 and 15 inhibited pancreatic lipase activity with an IC50 value of 9.0 and 6.5 μM, respectively.
authors.affiliation: College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju 362-763, Republic of Korea.
authors.forename: Yang Hee
authors.initials: YH
authors.lastname: Jo
authors.affiliation: College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju 362-763, Republic of Korea.
authors.forename: Seon Beom
authors.initials: SB
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju 362-763, Republic of Korea.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju 362-763, Republic of Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju 362-763, Republic of Korea.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.affiliation: College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju 362-763, Republic of Korea. Electronic address: mklee@chungbuk.ac.kr.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
mesh_terms: D001688:Biological Products; D005419:Flavonoids / Q000737:chemistry*; D008049:Lipase / Q000737:chemistry*; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D009765:Obesity / Q000188:drug therapy*; D010179:Pancreas / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D001688:Biological Products; D005419:Flavonoids; D010936:Plant Extracts; D008049:Lipase
keywords: Cudracuspiflavanone A; Cudrania tricuspidata; Moraceae; Pancreatic lipase