title: Benefit of ECG-gated rest and stress N-13 cardiac PET imaging for quantification of LVEF in ischemic patients.
abstract: BACKGROUND
  ECG-gated rest-stress cardiac PET can lead to simultaneous quantification of both left ventricular ejection fraction and flow impairment. In this study, our aim was to assess the benefit of rest and stress PET ejection fraction (EF) (EFp) in relation to single-photon emission computed tomography (SPECT) EF (EFs) and echocardiography EF (EFe). To this effect, the EFp was compared with EFs and EFe. Further, the relation between rest and stress EFp was also assessed.
  
  
  METHODS
  ECG-gated N-13 ammonia rest and stress PET imaging was performed in 26 patients. EFp values were obtained using gated reconstruction of the data in Flowquant. In 13 patients, EFs and EFe values were obtained through chart review. Correlation, analysis of variance, and Bland-Altman analyses were performed. P values less than 0.05 were used for statistical significance.
  
  
  RESULTS
  The rest and stress EFp values correlated significantly (r=0.80 and 0.71, respectively; P<0.05) with EFs values. There was moderate correlation with statistical significance (P<0.05) between the rest and stress EFp and EFe values (r=0.58 and 0.50, respectively). The mean rest and stress EFp values were not significantly different from mean EFs values. Also, the rest EFp and stress EFp values correlated well (r=0.81, P<0.05) and were not significantly different. Bland-Altman analysis showed no significant bias between the rest and stress EFp, and EFs, and EFe values.
  
  
  CONCLUSIONS
  Rest and stress EFp values obtained through an ECG-gated PET scan can be used for clinical diagnosis in place of conventional methods like SPECT and echocardiography.
authors.affiliation: Departments of aMechanical and Materials Engineering bNuclear Medicine cDepartment of Cardiology, Division of Cardiovascular Health and Disease dDepartment of Biomedical Engineering, University of Cincinnati eVeteran Affairs Medical Center, Cincinnati, Ohio, USA.
authors.forename: Srikara V
authors.initials: SV
authors.lastname: Peelukhana
authors.forename: Rupak
authors.initials: R
authors.lastname: Banerjee
authors.forename: Kranthi K
authors.initials: KK
authors.lastname: Kolli
authors.forename: Mariano
authors.initials: M
authors.lastname: Fernandez-Ulloa
authors.forename: Imran
authors.initials: I
authors.lastname: Arif
authors.forename: Mohamed
authors.initials: M
authors.lastname: Effat
authors.forename: Tarek
authors.initials: T
authors.lastname: Helmy
authors.forename: Hanan
authors.initials: H
authors.lastname: Kerr
mesh_terms: D055424:Cardiac-Gated Imaging Techniques; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D012146:Rest; D013312:Stress, Physiological; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*