title: A survey on the developmental intestinal microbiota research in China: The history, funding, and frontiers of gut bacteria.
abstract: Up to 100 trillion bacteria are harbored in the human intestine with a mutualistic and interdependent relationship with the host during a long period of co-evolution. The so-called intestinal microbiota (IM) fulfill important metabolic tasks and the impaired stability may lead to IM-related diseases, including inflammatory bowel disease (IBD), colorectal cancer (CRC), metabolic syndrome (MS), liver diseases, and so on. Here, we review the past and development of IM research in China, including the achievements that Chinese researchers have made both in basic and clinical scientific field. Moreover, we evaluate the contributions of the National Natural Science Foundation of China (NSFC), the 973 National Basic Research Program of China (973 Program), the 863 National High Technology Research and Development Program of China (863 Program), and funds from the public health industry in the field of IM research.
authors.affiliation: State Key Laboratory of Oncogene and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Hui Min
authors.initials: HM
authors.lastname: Chen
authors.affiliation: Division of Digestive Disease, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China.|National Natural Science Foundation of China, Beijing, China.
authors.forename: Xiao Wei
authors.initials: XW
authors.lastname: Liu
authors.affiliation: National Natural Science Foundation of China, Beijing, China.
authors.forename: Rui Juan
authors.initials: RJ
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Oncogene and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Jing Yuan
authors.initials: JY
authors.lastname: Fang
mesh_terms: D035843:Biomedical Research / Q000191:economics / Q000639:trends; D002681:China; D015179:Colorectal Neoplasms / Q000382:microbiology; D000069467:Fecal Microbiota Transplantation; D005767:Gastrointestinal Diseases / Q000628:therapy; D000069196:Gastrointestinal Microbiome; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000382:microbiology; D008107:Liver Diseases / Q000382:microbiology; D024821:Metabolic Syndrome / Q000382:microbiology; D012109:Research Support as Topic / Q000706:statistics & numerical data / Q000639:trends
keywords: colorectal neoplasms; inflammatory bowel diseases; metabolic syndrome; microbiota; research