title: [Expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and the clinicopathological implications].
abstract: OBJECTIVE
  To investigate the expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and explore the clinicopathological implications.
  
  
  METHODS
  Immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) were used to detect the expressions of SFRP4 and DKK1 in 66 cervical squamous cell carcinoma and 26 normal cervical specimens.
  
  
  RESULTS
  SFRP4 expression was significantly higher (P<0.01) and DKK1 expression was significantly lower (P<0.05) in the carcinoma tissues than in normal cervical tissues. DKK1 was negatively correlated with SFRP4 in the carcinoma tissues (P<0.01), and their expressions were associated with the clinical stages, tumor differentiation, depth of invasion and lymph node metastasis of the tumors (P<0.05).
  
  
  CONCLUSIONS
  SFRP4 and DKK1, the upstream components of the Wnt pathway, play a key role in the tumorigenesis of cervical squamous cell carcinoma, and their expressions are associated with the clinicopathological features of the malignancy.
authors.affiliation: Department of Gynecology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.E-mail: lixiuf120@163.com.
authors.forename: Xiufen
authors.initials: X
authors.lastname: Li
authors.forename: Anli
authors.initials: A
authors.lastname: Hou
authors.forename: Zhenhuan
authors.initials: Z
authors.lastname: Li
authors.forename: Shuqin
authors.initials: S
authors.lastname: Fang
authors.forename: Yali
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yawei
authors.initials: Y
authors.lastname: Xu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D011518:Proto-Oncogene Proteins; C501126:DKK1 protein, human; C118723:SFRP4 protein, human; D000094742:Secreted Frizzled-Related Proteins