title: Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis.
abstract: BACKGROUND
  Monitoring potential changes in the epidemiology of cystic fibrosis (CF) pathogens furthers our understanding of the potential impact of interventions.
  
  
  METHODS
  We performed a retrospective analysis using data reported to the Cystic Fibrosis Foundation Patient Registry (CFFPR) from 2006 to 2012 to determine the annual percent changes in the prevalence and incidence of selected CF pathogens. Pathogens included Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S aureus (MRSA), Haemophilus influenzae, Burkholderia cepacia complex, Stenotrophomonas maltophilia, and Achromobacter xylosoxidans. Changes in nontuberculous mycobacteria (NTM) prevalence were assessed from 2010 to 2012, when the CFFPR collected NTM species.
  
  
  RESULTS
  In 2012, the pathogens of highest prevalence and incidence were MSSA and P aeruginosa, followed by MRSA. The prevalence of A xylosoxidans and B cepacia complex were relatively low. From 2006 to 2012, the annual percent change in overall (as well as in most age strata) prevalence and incidence significantly decreased for P aeruginosa and B cepacia complex, but significantly increased for MRSA. From 2010 to 2012, the annual percent change in overall prevalence of NTM and Mycobaterium avium complex increased.
  
  
  CONCLUSIONS
  The epidemiology of CF pathogens continues to change. The causes of these observations are most likely multifactorial and include improvements in clinical care and infection prevention and control. Data from this study will be useful to evaluate the impact of new therapies on CF microbiology.
authors.affiliation: Columbia University Medical Center, New York, NY.
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Salsgiver
authors.affiliation: Cystic Fibrosis Foundation, Bethesda, MD.
authors.forename: Aliza K
authors.initials: AK
authors.lastname: Fink
authors.affiliation: Cystic Fibrosis Foundation, Bethesda, MD.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Knapp
authors.affiliation: University of Michigan, Ann Arbor, MI.
authors.forename: John J
authors.initials: JJ
authors.lastname: LiPuma
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Olivier
authors.affiliation: Cystic Fibrosis Foundation, Bethesda, MD.
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Marshall
authors.affiliation: Columbia University Medical Center, New York, NY. Electronic address: LS5@cumc.columbia.edu.
authors.forename: Lisa
authors.initials: L
authors.lastname: Saiman
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001419:Bacteria / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D012042:Registries; D012137:Respiratory System / Q000382:microbiology*; D012189:Retrospective Studies; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Pseudomonas aeruginosa; Staphylococcus aureus; cystic fibrosis; registry