title: Effect of CPP-ACP Paste on Enamel Carious Lesion of Primary Upper Anterior Teeth Assessed by Quantitative Light-Induced Fluorescence: A One-Year Clinical Trial.
abstract: The purpose of this clinical trial was to evaluate the effect of 1 year of daily application of 10% w/v CPP-ACP (casein phosphopeptide-amorphous calcium phosphate) paste in addition to regular toothbrushing with fluoridated toothpaste on the remineralization of enamel carious lesions in preschool children using quantitative light-induced fluorescence (QLF). A total of 103 Thai children (aged 2(1)/2-3(1)/2 years) with high caries risk who had at least 1 enamel carious lesion (ICDAS 1-3) on the labial surface of the upper anterior teeth were assigned to receive either CPP-ACP paste (n = 53) or placebo control (n = 50) following toothbrushing with fluoridated toothpaste after lunch at school. QLF measurement was performed at baseline, 6 months and 1 year. At 1 year, a significant reduction in fluorescence loss (ΔF), lesion area and lesion volume (ΔQ; p ≤ 0.001) of the lesions were found over time in both groups. However, no significant difference was observed between the groups (p = 0.79, 0.98 and 0.88, respectively). There was no statistically significant difference between the odds of ΔQ transition to a stage of regression or arrest compared with progression from baseline to 1 year between the two groups (OR = 1.03, 95% CI 0.31-3.39). The daily application of 10% w/v CPP-ACP paste on a school day for 1 year resulted in no improvement of enamel carious lesion remineralization in the primary upper anterior teeth as assessed by QLF. The lesion improvement was not superior to remineralization from regular toothbrushing with fluoridated toothpaste alone in these children.
authors.affiliation: Faculty of Dentistry, Thammasat University - Rangsit Campus, Patumthani, Thailand.
authors.forename: Thanya
authors.initials: T
authors.lastname: Sitthisettapong
authors.forename: Takashi
authors.initials: T
authors.lastname: Doi
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Nishida
authors.forename: Masaki
authors.initials: M
authors.lastname: Kambara
authors.forename: Prathip
authors.initials: P
authors.lastname: Phantumvanit
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use*; D002364:Caseins / Q000627:therapeutic use*; D002675:Child, Preschool; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D003733:Dental Caries Susceptibility; D003743:Dental Enamel / Q000187:drug effects*; D018450:Disease Progression; D004311:Double-Blind Method; D005260:Female; D005453:Fluorescence; D005459:Fluorides / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010919:Placebos; D018570:Risk Assessment; D017001:Tooth Demineralization / Q000517:prevention & control; D014089:Tooth Remineralization / Q000379:methods; D014094:Tooth, Deciduous / Q000187:drug effects*; D014099:Toothbrushing / Q000379:methods; D014100:Toothpastes / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; D010919:Placebos; D014100:Toothpastes; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D005459:Fluorides