title: A Meta-Analysis of Autobiographical Memory Studies in Schizophrenia Spectrum Disorder.
abstract: Meta-analyses and reviews on cognitive disorders in schizophrenia have shown that the most robust and common cognitive deficits are found in episodic memory and executive functions. More complex memory domains, such as autobiographical memory (AM), are also impaired in schizophrenia, but such impairments are reported less often despite their negative impact on patients' outcome. In contrast to episodic memory, assessed in laboratory tasks, memories of past personal events are much more complex and directly relate to the self. The meta-analysis included 20 studies, 571 patients with schizophrenia spectrum disorder, and 503 comparison subjects. It found moderate-to-large effect sizes with regard to the 3 parameters commonly used to assess AM: memory specificity (g = -0.97), richness of detail (g = -1.40), and conscious recollection (g = -0.62). These effect sizes were in the same range as those found in other memory domains in schizophrenia; for this reason, we propose that defective memories of personal past events should be regarded as a major cognitive impairment in this illness.
authors.affiliation: Fondation FondaMental, Créteil, France fabrice.berna@chru-strasbourg.fr.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Berna
authors.affiliation: INSERM U-1114, Strasbourg, France; Hôpitaux Universitaires de Strasbourg, Pôle de Psychiatrie et Santé Mentale, Strasbourg, France; FMTS: Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France;
authors.forename: Jevita
authors.initials: J
authors.lastname: Potheegadoo
authors.affiliation: UFR Mathématique et Informatique, Université de Strasbourg, Strasbourg, France;
authors.forename: Ismail
authors.initials: I
authors.lastname: Aouadi
authors.affiliation: Department of Psychology, University of Castilla La Mancha, Albacete, Spain; School of Medicine, Research Institute of Neurological Disabilities, Albacete, Spain;
authors.forename: Jorge Javier
authors.initials: JJ
authors.lastname: Ricarte
authors.affiliation: INSERM U-1114, Strasbourg, France; Faculté de Médecine, Université de Strasbourg, Strasbourg, France; FMTS: Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France;
authors.forename: Mélissa C
authors.initials: MC
authors.lastname: Allé
authors.affiliation: INSERM U-1114, Strasbourg, France; Centre Psychothérapique de Nancy, Centre de Ressources Autisme de Lorraine, Laxou, France;
authors.forename: Romain
authors.initials: R
authors.lastname: Coutelle
authors.affiliation: CHU Sainte-Marguerite, Pôle Psychiatrie Universitaire, Marseille, France; Fondation FondaMental, Créteil, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
authors.affiliation: Centre Hospitalier Universitaire de Reims, Département de Psychiatrie, Reims, France; UFR de Psychologie, Université de Toulouse 2 Le Mirail, Toulouse, France;
authors.forename: Christine Vanessa
authors.initials: CV
authors.lastname: Cuervo-Lombard
authors.affiliation: Fondation FondaMental, Créteil, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Danion
mesh_terms: D056344:Executive Function; D006801:Humans; D008569:Memory Disorders / Q000503:physiopathology* / Q000523:psychology; D061212:Memory, Episodic; D011939:Mental Recall; D000067250:Psychiatric Rehabilitation; D012559:Schizophrenia / Q000503:physiopathology* / Q000534:rehabilitation; D012565:Schizophrenic Psychology; D012649:Self Concept
keywords: cognitive remediation; conscious recollection; episodic memory; rehabilitation; self