title: Mouse genome annotation by the RefSeq project.
abstract: Complete and accurate annotation of the mouse genome is critical to the advancement of research conducted on this important model organism. The National Center for Biotechnology Information (NCBI) develops and maintains many useful resources to assist the mouse research community. In particular, the reference sequence (RefSeq) database provides high-quality annotation of multiple mouse genome assemblies using a combinatorial approach that leverages computation, manual curation, and collaboration. Implementation of this conservative and rigorous approach, which focuses on representation of only full-length and non-redundant data, produces high-quality annotation products. RefSeq records explicitly link sequences to current knowledge in a timely manner, updating public records regularly and rapidly in response to nomenclature updates, addition of new relevant publications, collaborator discussion, and user feedback. Whole genome re-annotation is also conducted at least every 12-18 months, and often more frequently in response to assembly updates or availability of informative data. This article highlights key features and advantages of RefSeq genome annotation products and presents an overview of NCBI processes to generate these data. Further discussion of NCBI's resources highlights useful features and the best methods for accessing our data.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Kelly M
authors.initials: KM
authors.lastname: McGarvey
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Tamara
authors.initials: T
authors.lastname: Goldfarb
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Cox
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Farrell
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Tripti
authors.initials: T
authors.lastname: Gupta
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Vinita S
authors.initials: VS
authors.lastname: Joardar
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Vamsi K
authors.initials: VK
authors.lastname: Kodali
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Murphy
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Nuala A
authors.initials: NA
authors.lastname: O'Leary
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Shashikant
authors.initials: S
authors.lastname: Pujar
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Bhanu
authors.initials: B
authors.lastname: Rajput
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Sanjida H
authors.initials: SH
authors.lastname: Rangwala
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Lillian D
authors.initials: LD
authors.lastname: Riddick
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: David
authors.initials: D
authors.lastname: Webb
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Mathew W
authors.initials: MW
authors.lastname: Wright
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.
authors.forename: Terence D
authors.initials: TD
authors.lastname: Murphy
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA. Pruitt@ncbi.nlm.nih.gov.
authors.forename: Kim D
authors.initials: KD
authors.lastname: Pruitt
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics*; D000818:Animals; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D016678:Genome; D020407:Internet; D051379:Mice