title: Contrast-Enhanced Sonography for Monitoring Neoadjuvant Chemotherapy in Soft Tissue Sarcomas.
abstract: Neoadjuvant chemotherapy is a mainstay in treating soft tissue sarcomas. Soft tissue sarcomas can show an increase in size and central necrosis, with a decrease in the viable tumor, as an initial response to neoadjuvant chemotherapy. Thus, the maximum tumor diameter may not reliably assess the response to this therapy. Contrast-enhanced sonography may address this limitation. We evaluated 4 patients with soft tissue sarcomas by contrast-enhanced sonography, performed concomitantly with conventional imaging (computed tomography, magnetic resonance imaging, or positron emission tomography). Quantitative analysis was also performed on 1 sarcoma. A viable, enhancing tumor versus tumor necrosis was nearly identical on contrast-enhanced sonography and conventional imaging. Preliminary results demonstrate potential for contrast-enhanced sonographic monitoring of soft tissue sarcomas during neoadjuvant chemotherapy.
authors.affiliation: Departments of Radiology (M.G., B.D., D.H.H., E.G.G., V.A.D.) and Medicine (J.S.H.), University of Southern California Keck School of Medicine, Los Angeles, California USA. mittul.gulati@med.usc.edu.
authors.forename: Mittul
authors.initials: M
authors.lastname: Gulati
authors.affiliation: Departments of Radiology (M.G., B.D., D.H.H., E.G.G., V.A.D.) and Medicine (J.S.H.), University of Southern California Keck School of Medicine, Los Angeles, California USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Hu
authors.affiliation: Departments of Radiology (M.G., B.D., D.H.H., E.G.G., V.A.D.) and Medicine (J.S.H.), University of Southern California Keck School of Medicine, Los Angeles, California USA.
authors.forename: Bhushan
authors.initials: B
authors.lastname: Desai
authors.affiliation: Departments of Radiology (M.G., B.D., D.H.H., E.G.G., V.A.D.) and Medicine (J.S.H.), University of Southern California Keck School of Medicine, Los Angeles, California USA.
authors.forename: Darryl H
authors.initials: DH
authors.lastname: Hwang
authors.affiliation: Departments of Radiology (M.G., B.D., D.H.H., E.G.G., V.A.D.) and Medicine (J.S.H.), University of Southern California Keck School of Medicine, Los Angeles, California USA.
authors.forename: Edward G
authors.initials: EG
authors.lastname: Grant
authors.affiliation: Departments of Radiology (M.G., B.D., D.H.H., E.G.G., V.A.D.) and Medicine (J.S.H.), University of Southern California Keck School of Medicine, Los Angeles, California USA.
authors.forename: Vinay A
authors.initials: VA
authors.lastname: Duddalwar
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D003287:Contrast Media; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D012509:Sarcoma / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014463:Ultrasonography / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media
keywords: contrast-enhanced sonography; neoadjuvant chemotherapy; quantitative analysis; soft tissue sarcoma