title: Spatially Weighted Principal Component Regression for High-Dimensional Prediction.
abstract: We consider the problem of using high dimensional data residing on graphs to predict a low-dimensional outcome variable, such as disease status. Examples of data include time series and genetic data measured on linear graphs and imaging data measured on triangulated graphs (or lattices), among many others. Many of these data have two key features including spatial smoothness and intrinsically low dimensional structure. We propose a simple solution based on a general statistical framework, called spatially weighted principal component regression (SWPCR). In SWPCR, we introduce two sets of weights including importance score weights for the selection of individual features at each node and spatial weights for the incorporation of the neighboring pattern on the graph. We integrate the importance score weights with the spatial weights in order to recover the low dimensional structure of high dimensional data. We demonstrate the utility of our methods through extensive simulations and a real data analysis based on Alzheimer's disease neuroimaging initiative data.
authors.forename: Dan
authors.initials: D
authors.lastname: Shen
authors.forename: Hongtu
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000368:Aged; D000465:Algorithms; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D062211:Spatio-Temporal Analysis