title: Prevalence and characteristics of hyporeflective preretinal tissue in vitreomacular interface disorders.
abstract: OBJECTIVE
  To assess prevalence and characteristics of hyporeflective preretinal tissue on spectral domain optical coherence tomography (SDOCT) in eyes with vitreomacular interface disorders.
  
  
  METHODS
  4037 eyes (3195 patients) with diagnosis of lamellar macular hole (LMH), full-thickness macular hole (FTMH), epiretinal membrane (ERM) and vitreomacular traction were included. Quantitative analysis was performed including volume and area of the epiretinal proliferation, as well as the brightness of the hyporeflective band. Clinical characteristics were also collected and analysed.
  
  
  RESULTS
  A hyporeflective preretinal tissue layer was identified in 204 of 4037 eyes (5.1%); 162 eyes in LMH (79.4%), 23 eyes in FTMH (11.3%) and 19 eyes in ERM (9.3%). In LMH, the visual acuity was significantly different between the cases with and without epiretinal proliferation at the initial visit and the final visit, (p=0.012, 0.046, respectively). The maximum thickness, area, volume of hyporeflective preretinal tissue became significantly larger during the observation period (p<0.001). Brightness of the preretinal tissue (109.3±21.1 arbitrary unit) was close to the retinal ganglion cell layer (112.0±19.5) and the retinal outer plexiform layer (117.7±19.5).
  
  
  CONCLUSIONS
  Hyporeflective preretinal tissue was found with significant frequency in eyes with LMH, FTMH and ERM, with a particularly high incidence in LMH. The increased presence of this tissue in cases of LMH may signify a particular subtype of LMH. More research is needed to better understand the implications of the presence of this tissue for visual and surgical outcomes.
authors.affiliation: Ophthalmic Imaging Center, Cleveland, Ohio, USA Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Itoh
authors.affiliation: Ophthalmic Imaging Center, Cleveland, Ohio, USA Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Ashleigh L
authors.initials: AL
authors.lastname: Levison
authors.affiliation: Ophthalmic Imaging Center, Cleveland, Ohio, USA Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Kaiser
authors.affiliation: Ophthalmic Imaging Center, Cleveland, Ohio, USA Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Srivastava
authors.affiliation: Ophthalmic Imaging Center, Cleveland, Ohio, USA Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Rishi P
authors.initials: RP
authors.lastname: Singh
authors.affiliation: Ophthalmic Imaging Center, Cleveland, Ohio, USA Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Justis P
authors.initials: JP
authors.lastname: Ehlers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019773:Epiretinal Membrane / Q000175:diagnosis*; D005128:Eye Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012160:Retina / Q000473:pathology*; D012167:Retinal Perforations / Q000175:diagnosis*; D012189:Retrospective Studies; D000267:Tissue Adhesions / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014822:Vitreous Body / Q000473:pathology*; D055815:Young Adult
keywords: Imaging; Pathology; Physiology; Retina; Treatment Surgery