title: A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines.
abstract: In this paper we describe the use of a chiral aldehyde derived from lactate esters for determining the enantiopurity of primary amines, via the formation of diastereomeric imines. The method was shown to be suitable for reproducibly determining the enantiopurity of a diverse set of chiral amines. Both enantiomers of the aldehyde can be prepared in two steps from commercially available materials.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon St, London, WC1H 0AJ, UK. tom.sheppard@ucl.ac.uk.
authors.forename: Samantha M
authors.initials: SM
authors.lastname: Gibson
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Lanigan
authors.forename: Laure
authors.initials: L
authors.lastname: Benhamou
authors.forename: Abil E
authors.initials: AE
authors.lastname: Aliev
authors.forename: Tom D
authors.initials: TD
authors.lastname: Sheppard