title: Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model.
abstract: BACKGROUND
  The medicinal plants Artemisia iwayomogi and Curcuma longa radix are both used to treat hyperlipidemia in traditional Korean and Chinese medicine.
  
  
  OBJECTIVE
  To evaluate the anti-hyperlipidemic effects of the 30% ethanol extracts of A. iwayomogi (AI), C. longa (CL), and the mixture of A. iwayomogi and C. longa (ACE), using a high-fat diet-induced hyperlipidemia model.
  
  
  METHODS
  Six of seven groups of C57BL/6N male mice (i.e., not including the naïve group) were fed a high-fat diet freely for 10 weeks. Of these six groups, five (i.e., not including the control group) were administered a high-fat diet supplemented with AI (100mg/kg), CL (100mg/kg), ACE (50 or 100mg/kg), or Lipitor (20mg/kg). Serum lipid profiles, obesity-related markers, hepatic steatosis, hepatic gene expression, and oxidative stress markers were analyzed.
  
  
  RESULTS
  AI, CL, and ACE were associated with significant effects on serum lipid profiles (total cholesterol [TC] and triglyceride), body, liver and peritoneal adipose tissue weights, hepatic lipid accumulation, and oxidative stress biomarkers. ACE at 100mg/kg was associated with significantly greater improvements in serum TC and triglyceride, hepatic triglyceride, epididymal adipocyte size, and oxidative stress biomarkers, compared with AI and CL. AI, CL and ACE normalized lipid synthesis-associated gene expression (peroxisome proliferator-activated receptor gamma, fatty acid synthase, sterol regulatory element-binding transcription factor-1c, and peroxisome proliferator-activated receptor alpha).
  
  
  CONCLUSIONS
  ACE exhibits anti-hyperlipidemia properties and is associated with partially synergistic effects compared with AI or CL alone.
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, Republic of Korea.
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Han
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, Republic of Korea.
authors.forename: Jin-Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, Republic of Korea.
authors.forename: Hyeong-Geug
authors.initials: HG
authors.lastname: Kim
authors.affiliation: Internal Medicine of Cardiac Vascular System, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, Republic of Korea.
authors.forename: In-Chan
authors.initials: IC
authors.lastname: Seol
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, Republic of Korea.
authors.forename: Hwi-Jin
authors.initials: HJ
authors.lastname: Im
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, Republic of Korea.
authors.forename: Jung-Hyo
authors.initials: JH
authors.lastname: Cho
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, Republic of Korea. Electronic address: ckson@dju.ac.kr.
authors.forename: Chang-Gue
authors.initials: CG
authors.lastname: Son
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D019306:Artemisia; D002784:Cholesterol / Q000097:blood; D030024:Curcuma; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D004357:Drug Synergism; D015870:Gene Expression / Q000187:drug effects; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D055670:Medicine, Korean Traditional; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
keywords: Artemisia iwayomogi; Curcuma longa radix; Hyperlipidemia; Synergistic effect; Traditional Korean medicine