title: In Situ Gelling Ophthalmic Drug Delivery System: An Overview and Its Applications.
abstract: Ophthalmic drug delivery system is very interesting and challenging due to the normal physiologically factor of eyes which reduces the bioavailability of ocular products. The development of new ophthalmic dosage forms for existing drugs to improve efficacy and bioavailability, patient compliance and convenience has become one of the main trend in the pharmaceuticals industry. The present review encompasses various conventional and novel ocular drug delivery systems, methods of preparation, characterization and recent research in this area. Furthermore, the information on various commercially available in situ gel preparations and the existing patents of in situ drug delivery systems i.e. in situ gel formation of pectin, in situ gel for therapeutic use, medical uses of in situ formed gels and in situ gelling systems as sustained delivery for front of eye are also covered in this review.
authors.affiliation: School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia. ravi_sheshala@imu.edu.my.
authors.forename: Ravi
authors.initials: R
authors.lastname: Sheshala
authors.forename: Yong Y
authors.initials: YY
authors.lastname: Kok
authors.forename: Jun M
authors.initials: JM
authors.lastname: Ng
authors.forename: Raghu R S
authors.initials: RR
authors.lastname: Thakur
authors.forename: Kamal
authors.initials: K
authors.lastname: Dua
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D005123:Eye / Q000378:metabolism; D005782:Gels; D006801:Humans; D065587:Ocular Absorption; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D004364:Pharmaceutical Preparations; D011108:Polymers