title: Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles.
abstract: The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo-fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[b]furan.
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology Getreidemarkt 9/163-OC, 1060 Vienna, Austria E-mail: michael.schnuerch@tuwien.ac.at http://www.ias.tuwien.ac.at/staff/3129565/
authors.forename: Toan
authors.initials: T
authors.lastname: Dao-Huy
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology Getreidemarkt 9/163-OC, 1060 Vienna, Austria E-mail: michael.schnuerch@tuwien.ac.at http://www.ias.tuwien.ac.at/staff/3129565/
authors.forename: Maximilian
authors.initials: M
authors.lastname: Haider
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology Getreidemarkt 9/163-OC, 1060 Vienna, Austria E-mail: michael.schnuerch@tuwien.ac.at http://www.ias.tuwien.ac.at/staff/3129565/
authors.forename: Fabian
authors.initials: F
authors.lastname: Glatz
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology Getreidemarkt 9/163-OC, 1060 Vienna, Austria E-mail: michael.schnuerch@tuwien.ac.at http://www.ias.tuwien.ac.at/staff/3129565/
authors.forename: Michael
authors.initials: M
authors.lastname: Schnürch
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology Getreidemarkt 9/163-OC, 1060 Vienna, Austria E-mail: michael.schnuerch@tuwien.ac.at http://www.ias.tuwien.ac.at/staff/3129565/
authors.forename: Marko D
authors.initials: MD
authors.lastname: Mihovilovic
keywords: Arylation; Concerted metal deprotonation; C–H activation; Fused-ring systems; Palladium; Regioselectivity; Synthetic methods