title: Research ethics needs fine tuning, not rigidity: how to promote evidence in neglected patient populations by rethinking informed consent.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands j.w.jukema@lumc.nl.
authors.forename: J Wouter
authors.initials: JW
authors.lastname: Jukema
authors.affiliation: MEDCON International, Heemstede, The Netherlands.
authors.forename: Judith R
authors.initials: JR
authors.lastname: Brouwer
authors.affiliation: Department of Cardiology, University Heart Centre, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Lüscher
authors.affiliation: Department of Health Care Ethics and Health Law, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Dick P
authors.initials: DP
authors.lastname: Engberts
authors.affiliation: Einthoven Laboratory for Experimental Vascular Medicine, Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: Paul H A
authors.initials: PH
authors.lastname: Quax
mesh_terms: D030881:Disclosure; D032984:Ethics, Research; D006801:Humans; D007258:Informed Consent / Q000941:ethics*; D018579:Patient Selection / Q000941:ethics; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic / Q000941:ethics