title: Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis.
abstract: Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection. A characteristic feature of MS is an intrathecal synthesis of immunoglobulin (Ig)G. In 90 patients with clinically isolated syndromes/early relapsing-remitting MS, serum antibodies to Epstein-Barr nuclear antigen-1, but not to EBV viral capsid antigen, rubella, or varicella zoster virus, were higher (p=0.03) in those with than those without a calculated intrathecal IgG synthesis >0% and correlated with the percentage (r=0.27, p=0.009) and concentration (r=0.27, p=0.012) of intrathecally produced IgG. These findings suggest a link between EBV infection and the events leading to intrathecal IgG synthesis in patients with MS.
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Catherina
authors.initials: C
authors.lastname: Pfuhl
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Johanna
authors.initials: J
authors.lastname: Oechtering
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Ludwig
authors.initials: L
authors.lastname: Rasche
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: René M
authors.initials: RM
authors.lastname: Gieß
authors.affiliation: NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Janina R
authors.initials: JR
authors.lastname: Behrens
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Wakonig
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Erik
authors.initials: E
authors.lastname: Freitag
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Florence C
authors.initials: FC
authors.lastname: Pache
authors.affiliation: St. Josefs-Krankenhaus Potsdam, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Otto
authors.affiliation: Institute of Medical Virology, Charité - Universitätsmedizin Berlin, Germany; Labor Berlin Charité-Vivantes GmbH, Berlin, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Hofmann
authors.affiliation: Labor Berlin Charité-Vivantes GmbH, Berlin, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Eberspächer
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany; Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Bellmann-Strobl
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany; Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.
authors.forename: Friedemann
authors.initials: F
authors.lastname: Paul
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Germany. Electronic address: klemens.ruprecht@charite.de.
authors.forename: Klemens
authors.initials: K
authors.lastname: Ruprecht
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000097:blood; D015415:Biomarkers / Q000097:blood; D036022:Capsid Proteins / Q000097:blood; D015331:Cohort Studies; D042241:Early Diagnosis; D019309:Epstein-Barr Virus Nuclear Antigens / Q000097:blood*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000175:diagnosis* / Q000821:virology; D011446:Prospective Studies; D013116:Spinal Cord / Q000378:metabolism* / Q000821:virology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D015415:Biomarkers; D036022:Capsid Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; D007074:Immunoglobulin G; C417029:EBV-encoded nuclear antigen 1
keywords: Antibodies; Epstein–Barr nuclear antigen-1; Epstein–Barr virus; Intrathecal immunoglobulin G; Multiple sclerosis; Oligoclonal bands