title: Chemical composition and biological evaluation of the volatile constituents from the aerial parts of Nephrolepis exaltata (L.) and Nephrolepis cordifolia (L.) C. Presl grown in Egypt.
abstract: The essential oil from the aerial parts of Nephrolepis exaltata and Nephrolepis cordifolia obtained by hydro-distillation were analyzed by gas chromatography/ mass spectrometry. The essential oils exhibited potential antibacterial and antifungal activities against a majority of the selected microorganisms. NEA oil showed promising cytotoxicity in breast, colon and lung carcinoma cells. The results presented indicate that NEA oil could be useful alternative for the treatment of dermatophytosis. Comparative investigation of hydro-distilled volatile constituents from aerial parts (A) of Nephrolepis exaltata (NE) and Nephrolepis cordifolia (NC) (Family Nephrolepidaceae) was carried out. Gas chromatography/mass spectrometry revealed that oils differ in composition and percentages of components. Oxygenated compounds were dominant in NEA and NCA. 2,4-Hexadien-1-ol (16.1%), nonanal (14.4%), β-Ionone (6.7%) and thymol (2.7%) were predominant in NEA. β-Ionone (8.0%), eugenol (7.2%) and anethol (4.6%) were the main constituents in NCA. Volatile samples were screened for their antibacterial and antifungal activities using agar diffusion method and minimum inhibitory concentrations. The cytotoxic activity was evaluated using viability assay in breast (MCF-7), colon (HCT-116) and lung carcinoma (A-549) cells by the MTT assay. The results revealed that NEA oil exhibited potential antimicrobial activity against most of the tested organisms and showed promising cytotoxicity.
authors.affiliation: a Department of Pharmacognosy , National Organization for Drug Control and Research (NODCAR) , Cairo , Egypt.
authors.forename: Mona E
authors.initials: ME
authors.lastname: El-Tantawy
authors.affiliation: a Department of Pharmacognosy , National Organization for Drug Control and Research (NODCAR) , Cairo , Egypt.
authors.forename: Manal M
authors.initials: MM
authors.lastname: Shams
authors.affiliation: b Department of Pharmacognosy , Faculty of Pharmacy, Misr International University , Cairo , Egypt.
authors.forename: Manal S
authors.initials: MS
authors.lastname: Afifi
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification; D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000737:chemistry / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D004534:Egypt; D005054:Eugenol / Q000737:chemistry / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D000441:Hexanols / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology; D029621:Polypodiaceae / Q000737:chemistry* / Q000145:classification; D013943:Thymol / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000447:Aldehydes; D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D000441:Hexanols; D045792:Norisoprenoids; D009822:Oils, Volatile; D010938:Plant Oils; C065785:sorbyl alcohol; C008664:nonanal; D013943:Thymol; D005054:Eugenol; C008157:beta-ionone; C006578:anethole
keywords: Nephrolepis cordifolia; Nephrolepis exaltata; antibacterial; antifungal; cytotoxicity; volatile constituents