title: MicroRNAs in Bone Balance and Osteoporosis.
abstract: Preclinical Research Bone is a rigid and dynamic organ that undergoes continuous turnover. Bone homeostasis is maintained by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The interruption of this balance can cause various diseases, including osteoporosis a public health issue due to the rate of hip fracture, the most serious outcome of osteoporosis. The bone loss in osteoporosis results from an increase in bone resorption versus bone formation. Thus, regulation of osteoblast and osteoclast activity is a main focus in the treatment of osteoporosis. MicroRNAs (miRNAs) are a class of single stranded noncoding RNAs consisting of 18-22 nucleotides that have an important role in cell differentiation, cell fate, apoptosis, and pathogenesis in various disease states. The potential therapeutic and biomarker function of miRNAs in treating bone disorders is receiving more attention. The current review summarizes the role of miRNAs in bone function at a cellular level in the context of their therapeutic potential.
authors.affiliation: Department of Pathology, 324 Hospital of People's Liberation Army, Chongqing, China.
authors.forename: Junying
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pathology, 324 Hospital of People's Liberation Army, Chongqing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Qiu
authors.affiliation: Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Dou
authors.affiliation: Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cao
authors.affiliation: Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Shiwu
authors.initials: S
authors.lastname: Dong
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001842:Bone and Bones / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: bone balance; microRNA; osteoblast; osteoclasts; osteoporosis