title: Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients.
abstract: BACKGROUND
  Mimecan plays an important role in endothelial and vascular smooth muscle cell integrity and may be involved the pathology of arterial stiffness. However, the role of mimecan in arterial stiffness in patients with hypertension is not well defined.
  
  
  RESULTS
  A total of 116 hypertension patients and 54 healthy controls were enrolled in the investigation. Hypertensive patients were divided into 2 groups: the with arterial stiffness group (brachial-ankle pulse wave velocity [baPWV] ≥1400 cm/s; n=83) and the without arterial stiffness group (baPWV <1400 cm/s; n=33). A noninvasive measure of vascular stiffness was performed using pulse wave velocity (PWV) measurement of baPWV. Hypertensive patients had higher baPWV, mimecan, and endothelin 1 (ET-1) than healthy controls. The arterial stiffness group had higher mimecan and endothelin 1 (ET-1) and lower ankle-brachial pressure index (ABI) than those without stiffness. In hypertensive patients, mimecan was inversely correlated with ABI (P<0.05) and positively correlated with baPWV, ET-1, and total cholesterol. On multivariable logistic regression analysis, diastolic blood pressure, mimecan, ET-1, and creatinine were independent predictors of arterial stiffness in hypertensive patients (P<0.05).
  
  
  CONCLUSIONS
  Mimecan levels are higher in hypertensive patients than in healthy controls. Increased plasma mimecan levels are independently associated with increased arterial stiffness as assessed by baPWV.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
authors.forename: Liangping
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
authors.forename: Haibo
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Wayne State University School of Medicine, Detroit, MI (L.W.).
authors.forename: Luchen
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
authors.forename: Weiting
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
authors.forename: Jianchang
authors.initials: J
authors.lastname: Chen
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D062186:Arterial Pressure; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002784:Cholesterol / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D063177:Pulse Wave Analysis; D015854:Up-Regulation; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D036341:Intercellular Signaling Peptides and Proteins; C063488:OGN protein, human; D002784:Cholesterol
keywords: ET‐1; arterial stiffness; hypertension; mimecan