title: Correction of vitamin D deficiency in a cohort of newborn infants using daily 200 IU vitamin D supplementation.
abstract: BACKGROUND
  Although the role of vitamin D in the prevention of rickets has long been well established, controversies still exist on the ideal dose of vitamin D supplementation in infants.
  
  
  OBJECTIVE
  We assessed serum 25-hydroxyvitamin D (25OHD) status simultaneously in maternal and cord samples and the response to vitamin D3 supplementation in neonates.
  
  
  METHODS
  Serum 25OHD levels were evaluated from maternal, and umbilical cord samples from term normal pregnancies. Repeat 25OHD levels were assessed in neonates with 25OHD below 30 nmol/L following vitamin D3 200 IU daily after 6 weeks.
  
  
  RESULTS
  Blood samples were taken including 57 cord samples and 16 follow-up neonatal samples. Maternal and cord serum 25OHD were 43 ± 21 and 29 ± 15 nmol/L, respectively. Infants with 25OHD < 30 nmol/L (19.8 ± 4.7 nmol/L) had a significant increase in serum 25OHD (63.3 ± 14.5 nmol/L) following vitamin D3 200 IU daily after 6 weeks.
  
  
  CONCLUSIONS
  Healthy Irish infants born at term are at high risk of vitamin D deficiency, but vitamin D3 200 IU daily, rapidly corrects poor vitamin D status.
authors.affiliation: Department of Neonatology, National Maternity Hospital, Dublin, Ireland. chike.onwuneme@gmail.com.|Department of Paediatrics, Children's University Hospital, Temple Street, Dublin, Ireland. chike.onwuneme@gmail.com.|Department of Medicine & Medical Sciences, University College Dublin, Dublin, Ireland. chike.onwuneme@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Onwuneme
authors.affiliation: Department of Neonatology, National Maternity Hospital, Dublin, Ireland.
authors.forename: B
authors.initials: B
authors.lastname: Diya
authors.affiliation: Department of Neonatology, National Maternity Hospital, Dublin, Ireland.
authors.forename: O
authors.initials: O
authors.lastname: Uduma
authors.affiliation: Department of Neonatology, National Maternity Hospital, Dublin, Ireland.
authors.forename: R A
authors.initials: RA
authors.lastname: McCarthy
authors.affiliation: Department of Paediatrics, Children's University Hospital, Temple Street, Dublin, Ireland.
authors.forename: N
authors.initials: N
authors.lastname: Murphy
authors.affiliation: Department of Metabolism and Endocrinology, St Vincent's University Hospital, Dublin, Ireland.
authors.forename: M T
authors.initials: MT
authors.lastname: Kilbane
authors.affiliation: Department of Medicine & Medical Sciences, University College Dublin, Dublin, Ireland.|Department of Metabolism and Endocrinology, St Vincent's University Hospital, Dublin, Ireland.
authors.forename: M J
authors.initials: MJ
authors.lastname: McKenna
authors.affiliation: Department of Neonatology, National Maternity Hospital, Dublin, Ireland.|Department of Medicine & Medical Sciences, University College Dublin, Dublin, Ireland.|Department of Paediatrics, Department of Paediatrics, Royal College of Surgeons of Ireland, Dublin, Ireland.|Department of Neonatology, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.|Department of Paediatrics, Trinity College Dublin, Dublin, Ireland.|Department of Paediatrics, Trinity Centre for Health Sciences, Adelaide and Meath Hospital Dublin incorporating The National Children's Hospital (AMNCH), Tallaght, Dublin 24, Ireland.
authors.forename: E J
authors.initials: EJ
authors.lastname: Molloy
mesh_terms: D001942:Breast Feeding; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000172:deficiency; D019587:Dietary Supplements; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D012621:Seasons; D016896:Treatment Outcome; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000178:diet therapy*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins; D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D
keywords: Neonates; Supplementation; Term infants; Vitamin D