title: Mannose-Binding Lectin and Diabetic Nephropathy in Type 1 Diabetes.
abstract: OBJECTIVE
  The aim of this study was to investigate serum levels of mannose-binding lectin (MBL) in type 1 diabetes with diabetic nephropathy (DN) and persistent normoalbuminuria (PN).
  
  
  METHODS
  Serum MBL levels were determined in 224 type 1 diabetes with overt nephropathy and 224 type 1 diabetes with PN matched for sex, age, and duration of diabetes The prediction value of MBL was compared with hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein (Hs-CRP) and other known predictors. Multivariate analyses were performed using logistic regression models.
  
  
  RESULTS
  The serum MBL levels were significantly higher in diabetes with DN as compared to with PN (P < 0.0001). Based on the receiver operating characteristic (ROC) curve, the optimal cutoff value of serum MBL levels as an indicator for diagnosis of DN was projected to be 1,680 μg/l, which yielded a sensitivity of 75.4% and a specificity of 78.8%, with the area under the curve at 0.768 (95% confidence interval [CI], 0.724-0.815). Multivariate logistic regression analysis adjusted for common factors showed that serum MBL level ≥ 1,680 μg/l was an independent indictor of DN (odds ratio [OR] = 6.99; 95% CI: 2.83-17.15).
  
  
  CONCLUSIONS
  In type 1 diabetic patient, evaluated serum levels of MBL can be seen as an independent marker of DN even after correcting for possible confounding factors.
authors.affiliation: Emergency Department, Linyi People's Hospital of Shandong University, Linyi, China.
authors.forename: Shi-Qi
authors.initials: SQ
authors.lastname: Zhao
authors.affiliation: Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Hu
mesh_terms: D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D012372:ROC Curve
chemical_list: D037601:Mannose-Binding Lectin
keywords: Chinese; diabetic nephropathy; mannose-binding lectin; risk; type 1 diabetes