title: [Analysis of Cytokines Related to Helper T and Regulatory T Cells in the Vitreous of Uveitis Patients].
abstract: OBJECTIVE
  To investigate helper T (Th) cell-related cytokines elevated in the vitreous of endogenous uveitis (EU), and to compare these with those of acute retinal necrosis (ARN).
  
  
  METHODS
  Vitreous fluids were obtained from 23 eyes of EU patients, 4 eyes of ARN patients, and 14 eyes of patients with epiretinal membrane (ERM) who had had vitrectomy surgery. The vitreous levels of interleukin (IL)-1, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, interferon (IFN)-γ, soluble CD40 ligand (sCD40L) and tumor necrosis factor (TNF)-α were measured.
  
  
  RESULTS
  The vitreous cytokine levels of IL-6, IL-10, IL-31, IFN-γ and TNF-α in the EU patients were significantly higher than in the ERM patients. On the other hand, the levels of IL-1β, IL-6, IL-10, IL-31, IFN-γ, sCD40L and TNF-α were significantly higher in the ARN patients than in the EU patients, while those of IL-4, IL-17A and IL-22 were higher in the EU patients than in the ARN patients although they were not significant.
  
  
  CONCLUSIONS
  It is suggested that Th1-, Th2- and Th17 cells are related to the development of EU, and Th1- and regulatory T cells to that of ARN, and that the severity of ocular inflammation may be associated with the activity of Th1 cells.
authors.forename: Masaki
authors.initials: M
authors.lastname: Shibata
authors.forename: Tomohito
authors.initials: T
authors.lastname: Sato
authors.forename: Manzo
authors.initials: M
authors.lastname: Taguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanaka
authors.forename: Kouzo
authors.initials: K
authors.lastname: Harimoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Takeuchi
mesh_terms: D016207:Cytokines / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015882:Retinal Necrosis Syndrome, Acute / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory; D014605:Uveitis / Q000276:immunology*; D014822:Vitreous Body / Q000737:chemistry*
chemical_list: D016207:Cytokines