title: A Sense of Self: RIG-I's Tolerance to Host RNA.
abstract: The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner et al. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.
authors.affiliation: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: john.schoggins@utsouthwestern.edu.
authors.forename: John W
authors.initials: JW
authors.lastname: Schoggins
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics*; D012313:RNA / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D015005:Yellow fever virus / Q000201:enzymology*
chemical_list: D012313:RNA; D053487:DEAD-box RNA Helicases