title: BDNF, IGF-I, Glucose and Insulin during Continuous and Interval Exercise in Type 1 Diabetes.
abstract: Type 1 diabetes (T1D) can have a significant impact on brain function, mostly ascribed to episodes of hypoglycemia and chronic hyperglycemia. Exercise has positive effects on acute and chronic glycemic control in T1D, and has beneficial effects on cognitive function by increasing neurotrophins such as BDNF and IGF-I in non-diabetic humans. The present study examines the effects of different types of exercise intensities on neurotrophins in T1D. 10 participants with type 1 diabetes were evaluated in 3 sessions: high-intensity exercise (10×[60 s 90%Wmax, 60 s 50 W]), continuous exercise (22 min, 70% VO2 max) and a control session. Blood glucose, serum free insulin, serum BDNF and IGF-I were assessed pre/post all the trials and after recovery. Blood glucose significantly decreased after both exercise intensities and BDNF levels increased, with a dose-response effect for exercise intensity on BDNF. IGF-I changed over time, but without a difference between the different exercise protocols. Both exercise intensities change neurotrophins in T1D, but also exhibit a dose response effect for BDNF. The intensity-dependent findings may aid in designing exercise prescriptions for maintaining or improving neurological health in T1D, but both types of exercise can be implemented.
authors.affiliation: Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Tonoli
authors.affiliation: University of Lille; URePSSS, Physical Activity, Muscle Health Research Team, Lille, France.
authors.forename: E
authors.initials: E
authors.lastname: Heyman
authors.affiliation: Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Roelands
authors.affiliation: Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Buyse
authors.affiliation: Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Piacentini
authors.affiliation: University of Lille; URePSSS, Physical Activity, Muscle Health Research Team, Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Berthoin
authors.affiliation: Department of Physical Therapy Education, Elon University, Elon, United States.
authors.forename: S
authors.initials: S
authors.lastname: Bailey
authors.affiliation: Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Pattyn
authors.affiliation: Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Meeusen
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003071:Cognition / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000523:psychology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male
chemical_list: D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; D007328:Insulin; D007334:Insulin-Like Growth Factor I