title: An enzootic outbreak of acute disease associated with pathogenic E. coli in Adler monkey colony.
abstract: BACKGROUND
  In spring 2009 in Adler colony of the Institute of Medical Primatology, a large enzootic outbreak of acute intestine infection associated with pathogenic E. coli occurred and caused 5% mortality of population (209 animals).
  
  
  METHODS
  The epidemiological analysis, bacteriological investigation, postmortem examination, histological analysis, and PCR were used to identify the infectious agent.
  
  
  RESULTS
  Marked hemorrhagic diathesis, lethargy, dehydration, diarrhea with blood, wasting, and sometimes dystrophic changes in articular cartilages were noted. Morphologically, hemorrhagic enterocolitis and massive hemorrhages were found. PCR investigation of bacteriologically isolated E. coli characterized it as enteropathogenic and enteroinvasive E. coli.
  
  
  CONCLUSIONS
  The outbreak in Adler colony slightly differed from similar outbreak in Florida in 2014 by more marked hemorrhagic diathesis and articular changes in some monkeys caused by polyavitaminosis developed in the course of infection. Sensitive to infection were M. mulatta, M. fascicularis, Cercopithecus aethiops, P. hamadryas and anubis, and Cebus capucinus.
authors.affiliation: Research Institute of Medical Primatology, Sochi Adler region, Russian Federation.
authors.forename: Boris A
authors.initials: BA
authors.lastname: Lapin
authors.affiliation: Research Institute of Medical Primatology, Sochi Adler region, Russian Federation.
authors.forename: Lelita A
authors.initials: LA
authors.lastname: Yakovleva
authors.affiliation: Research Institute of Medical Primatology, Sochi Adler region, Russian Federation.
authors.forename: Eteri K
authors.initials: EK
authors.lastname: Dzhikidze
authors.affiliation: Research Institute of Medical Primatology, Sochi Adler region, Russian Federation.
authors.forename: Tatiana E
authors.initials: TE
authors.lastname: Gvozdik
authors.affiliation: Research Institute of Medical Primatology, Sochi Adler region, Russian Federation.
authors.forename: Aslan A
authors.initials: AA
authors.lastname: Agumava
authors.affiliation: Research Institute of Medical Primatology, Sochi Adler region, Russian Federation.
authors.forename: Zinaida K
authors.initials: ZK
authors.lastname: Stasilevich
authors.affiliation: Research Institute of Medical Primatology, Sochi Adler region, Russian Federation.
authors.forename: Irina G
authors.initials: IG
authors.lastname: Danilova
mesh_terms: D000818:Animals; D004196:Disease Outbreaks / Q000662:veterinary*; D054308:Enteropathogenic Escherichia coli / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D000882:Haplorhini; D006799:Housing, Animal; D008992:Monkey Diseases / Q000453:epidemiology / Q000382:microbiology*; D012426:Russia / Q000453:epidemiology; D013997:Time Factors
keywords: colibacillosis; enterohemorrhagic E. coli; enteroinvasive E. coli; enteropathogenic E. coli; enzootic outbreak; hemorrhagic enterocolitis; intestine infection