title: Research and development of therapeutic mAbs: An analysis based on pipeline projects.
abstract: As the subject of active research and development (R&D) in recent decades, monoclonal antibodies have emerged among the major classes of therapeutic agents for treatment of many human diseases, especially cancers, infections, and immunological disorders. This article surveys the landscape of R&D projects of therapeutic monoclonal antibodies (mAbs), which are mostly used for disease immunotherapy, from a number of perspectives, including therapeutic indications, development phases, participants, and citation of related patents. The results of this research can be used as a reference resource for pharmaceutical researchers, investors, and policymakers in the field of therapeutic mAbs.
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau ; Macau SAR , China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Geng
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau ; Macau SAR , China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Kong
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau ; Macau SAR , China.
authors.forename: Hao
authors.initials: H
authors.lastname: Hu
authors.affiliation: b College of Medical Bioengineering and Faculty of Life Sciences; Chongqing University ; Chongqing , China.|c Department of Biochemistry and Molecular Biology ; Zunyi Medical College ; Zunyi , China.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Chen
authors.affiliation: d Department of Pharmaceutics ; School of Chemistry and Chemical Engineering; Chongqing University ; Chongqing , China.
authors.forename: Fengqing
authors.initials: F
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau ; Macau SAR , China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Liang
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau ; Macau SAR , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau ; Macau SAR , China.
authors.forename: Yuanjia
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal
keywords: R&D; development trends; monoclonal antibody; patent citation network; pipeline projects; therapeutic application