title: [The clinical effect observation for surgery of nose and pharyngeal auxiliary oral appliance in severe OSAHS].
abstract: OBJECTIVE
  To investigate the therapeutic effects of oral modified device combined with nasopharyngeal enlargement surgery and evaluate the oral modified device' s adjuvant therapy meaning in severe OSAHS patients after surgery treatment.
  
  
  METHODS
  46 cases with severe OSAHS were diagnosed by PSG according to AHI and the lowest arterial oxygen saturation (LSaO2). We performed the nasal or pharyngeal cavity expansion surgery for them according to the pathological change part correspondingly. Then all subjects were divided into combined group (n=26) and surgery alone group (n=20) according to their personal willingness. We monitored the PSG for all subjects aftter 2 weeks and 3 months respectively, then we calculate the diversity between the two group or intragroup change on the basis of the AHI, LAT, LSaO2, mean arterial oxygen saturation (MSaO2) and sleep structures recorded by PSG. At the same time, we collected the subjective sensations by questionnaire.
  
  
  RESULTS
  The AHI and LAT in combined group were significantly lower and LSaO2 was significantly higher than these in surgery alone group(P<0. 05), and it's no difference in MSO2 between the two groups (P>0. 05). The N 1% was more shorter and the N2% and N3% were more longer after nasal or pharyngeal operation compared with pre-operative states in both groups(P<. 05), but we didn't find difference in REM%(P>. 05). The data of PSG also showed that the shallow sleep proportion was more shorter and the slow wave sleep proportion was more longer in combined group compared with surgery alone group. The subjective sensations results also showed significantly alleviated in combined group, such as mental state, daytime sleepiness and physical strength. The efficiency ratio of treatment was 85. 0% and 92. 3% in surgery alone group and combined group respectively.
  
  
  CONCLUSIONS
  Nasal and pharyngeal cavity enlargement surgery combined with oral modified device is a more effective treatment in patients with severe OSAHS, and it is meaningful for the long-term curative effect of surgery to prevent relapse and improve.
authors.forename: Peilin
authors.initials: P
authors.lastname: Hui
authors.forename: Yuping
authors.initials: Y
authors.lastname: Xie
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Wei
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Ning
authors.forename: Chao
authors.initials: C
authors.lastname: Xu
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Kang
mesh_terms: D006801:Humans; D009305:Nasopharynx / Q000601:surgery*; D009666:Nose / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures; D010092:Oximetry; D012677:Sensation; D012890:Sleep; D020181:Sleep Apnea, Obstructive / Q000601:surgery*; D012894:Sleep Stages; D016896:Treatment Outcome