title: Hemostatic Parameters according to Renal Function and Time after Transplantation in Brazilian Renal Transplanted Patients.
abstract: Kidney transplantation is the key for patients with end-stage renal disease, improving quality of life and longer survival. However, kidney transplant triggers an intense inflammatory response and alters the hemostatic system, but the pathophysiological mechanisms of these changes are not completely understood. The aim of this cross-sectional cohort study was to investigate hemostatic biomarkers in Brazilian renal transplanted patients according to renal function and time after transplantation. A total of 159 renal transplanted patients were enrolled and D-Dimer (D-Di), Thrombomodulin (TM), von Willebrand Factor (VWF), and ADAMTS13 plasma levels were assessed by ELISA. An increase of D-Di was observed in patients with higher levels of creatinine. ADAMTS13 levels were associated with creatinine plasma levels and D-Di levels with Glomerular Filtration Rate. These results suggested that D-Di and ADAMTS13 can be promising markers to estimate renal function. ADAMTS13 should be investigated throughout the posttransplant time to clarify the participation of this enzyme in glomerular filtration and acceptance or rejection of the graft in Brazilian transplanted patients.
authors.affiliation: Departamento de Analises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270901 Belo Horizonte, MG, Brazil.
authors.forename: Ana Paula Lucas
authors.initials: AP
authors.lastname: Mota
authors.affiliation: Departamento de Analises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270901 Belo Horizonte, MG, Brazil.
authors.forename: Patrícia Nessralla
authors.initials: PN
authors.lastname: Alpoim
authors.affiliation: Departamento de Ciências da Saúde, Faculdade de Farmácia, Universidade Federal de São João del-Rei, 35501296 Divinópolis, MG, Brazil.
authors.forename: Roberta Carvalho
authors.initials: RC
authors.lastname: de Figueiredo
authors.affiliation: Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais, 30130100 Belo Horizonte, MG, Brazil.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Simões e Silva
authors.affiliation: Departamento de Analises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270901 Belo Horizonte, MG, Brazil.
authors.forename: Karina Braga
authors.initials: KB
authors.lastname: Gomes
authors.affiliation: Departamento de Analises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270901 Belo Horizonte, MG, Brazil.
authors.forename: Luci Maria SantAna
authors.initials: LM
authors.lastname: Dusse
mesh_terms: D051722:ADAM Proteins / Q000097:blood; D000071120:ADAMTS13 Protein; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D051799:Delayed Graft Function / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006084:Graft Rejection / Q000097:blood; D006487:Hemostasis; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018180:Thrombomodulin / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D018180:Thrombomodulin; C036309:fibrin fragment D; D014841:von Willebrand Factor; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human