title: The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs.
abstract: Lanthanide elements have been documented to possess various biologic effects, and their compounds have been studied intensely for their anti-cancer potential. However, the underlying mechanisms remain largely unknown. In the present study, we propose that the levels of proliferation and apoptosis related microRNAs (miRNAs), let-7a and miR-34a, which mediate the apoptosis of cervical cancer cells, can be affected by the lanthanum ion. Our data showed that LaCl3 inhibited the proliferation and induced the apoptosis of cervical cancer cells both in vivo and in vitro by regulating let-7a, miR-34a and their downstream genes. This study provides novel evidence demonstrating that the anticancer mechanism of lanthanum chloride is partially attributed to miRNAs regulation and establishes an experimental basis for the clinical application of lanthanum chloride as an anti-cancer drug.
authors.affiliation: Burns Institute, The First Affiliated Hospital of Nanchang University, Nanchang, China.|Department of Obstetrics and Gynecology, The First People's Hospital of Wujiang City, Suzhou, China.
authors.forename: Lingfang
authors.initials: L
authors.lastname: Yu
authors.affiliation: Burns Institute, The First Affiliated Hospital of Nanchang University, Nanchang, China.|Department of Obstetrics and Gynecology, Jiangxi Maternal and Children Health Hospital, Nanchang, China.
authors.forename: Jieqi
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Obstetrics and Gynecology, Jiangxi Maternal and Children Health Hospital, Nanchang, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Lifang
authors.initials: L
authors.lastname: Miao
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Sisun
authors.initials: S
authors.lastname: Liu
authors.affiliation: Burns Institute, The First Affiliated Hospital of Nanchang University, Nanchang, China. guofei2005@126.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Guo
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007811:Lanthanum / Q000008:administration & dosage*; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs; C487931:mirnlet7 microRNA, human; C028521:lanthanum chloride; D007811:Lanthanum
keywords: Cervical cancer; Lanthanum chloride; Let-7a miRNA; MiR-34a; MicroRNAs