title: Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp. 318.
abstract: Four new lasiodiplodins (1-4), together with three known analogues, have been isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318#. Their structures were elucidated by spectroscopic techniques. Cytotoxic activities of compounds 1-7 were evaluated in vitro against human cancer lines THP1, MDA-MB-435, A549, HepG2 and HCT-116. Compound 4 exhibited moderate cytotoxic activities.
authors.affiliation: a School of Marine Sciences, Sun Yat-sen University , Guangzhou 510006 , P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: b School of Chemistry and Chemical Engineering, Sun Yat-sen University , Guangzhou 510275 , P.R. China.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Xue
authors.affiliation: c Zhongshan medical college, Sun Yat-sen University , Guanghzhou 510800 , P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yuan
authors.affiliation: d School of Life Sciences, Sun Yat-sen University , Guangzhou 510275 , P.R. China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Lu
authors.affiliation: c Zhongshan medical college, Sun Yat-sen University , Guanghzhou 510800 , P.R. China.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: b School of Chemistry and Chemical Engineering, Sun Yat-sen University , Guangzhou 510275 , P.R. China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
authors.affiliation: a School of Marine Sciences, Sun Yat-sen University , Guangzhou 510006 , P.R. China.
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D001203:Ascomycota / Q000737:chemistry*; D032407:Avicennia / Q000382:microbiology*; D045744:Cell Line, Tumor; D060026:Endophytes / Q000737:chemistry; D005285:Fermentation; D006801:Humans; D003904:Mitosporic Fungi; D015394:Molecular Structure; D015025:Zearalenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000970:Antineoplastic Agents; C417552:lasiodiplodin; D015025:Zearalenone
keywords: cytotoxic activity; endophytic fungus; lasiodiplodins