title: Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).
abstract: The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.
authors.affiliation: Centre of Infection and Immunity, The Queens's University of Belfast, Belfast, UK.
authors.forename: Liam G
authors.initials: LG
authors.lastname: Heaney
authors.affiliation: Academic Unit of Clinical and Experimental Sciences, University of Southampton, Southampton, UK.
authors.forename: Ratko
authors.initials: R
authors.lastname: Djukanovic
authors.affiliation: Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
authors.forename: Ashley
authors.initials: A
authors.lastname: Woodcock
authors.affiliation: Asthma UK, London, UK Genentech Inc., South San Francisco, California, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Walker
authors.affiliation: Genentech Inc., South San Francisco, California, USA.
authors.forename: John G
authors.initials: JG
authors.lastname: Matthews
authors.affiliation: Nuffield Department of Medicine, The University of Oxford, Oxford, UK.
authors.forename: Ian D
authors.initials: ID
authors.lastname: Pavord
authors.affiliation: Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Bradding
authors.affiliation: Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Niven
authors.affiliation: Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK.
authors.forename: Chris E
authors.initials: CE
authors.lastname: Brightling
authors.affiliation: Greater Glasgow Health Board, Glasgow, UK.
authors.forename: Rekha
authors.initials: R
authors.lastname: Chaudhuri
authors.affiliation: Genentech Inc., South San Francisco, California, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Arron
authors.affiliation: Genentech Inc., South San Francisco, California, USA.
authors.forename: David F
authors.initials: DF
authors.lastname: Choy
authors.affiliation: Greater Glasgow Health Board, Glasgow, UK.
authors.forename: Douglas
authors.initials: D
authors.lastname: Cowan
authors.affiliation: Heart of England NHS Foundation Trust, Birmingham, UK.
authors.forename: Adel
authors.initials: A
authors.lastname: Mansur
authors.affiliation: Royal Brompton & Harefield NHS Foundation Trust, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Menzies-Gow
authors.affiliation: Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Adcock
authors.affiliation: Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: Kian F
authors.initials: KF
authors.lastname: Chung
authors.affiliation: Kings College London, London, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Corrigan
authors.affiliation: Centre of Infection and Immunity, The Queens's University of Belfast, Belfast, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Coyle
authors.affiliation: University of Nottingham, Nottingham, UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Harrison
authors.affiliation: Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Johnston
authors.affiliation: Academic Unit of Clinical and Experimental Sciences, University of Southampton, Southampton, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Howarth
authors.affiliation: The Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.
authors.forename: James
authors.initials: J
authors.lastname: Lordan
authors.affiliation: School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Sabroe
authors.affiliation: Amgen Inc., Thousand Oaks, California, USA.
authors.forename: Jeannette
authors.initials: J
authors.lastname: Bigler
authors.affiliation: Amgen Inc., Thousand Oaks, California, USA.
authors.forename: Dirk
authors.initials: D
authors.lastname: Smith
authors.affiliation: Astra Zeneca, London, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Catley
authors.affiliation: Astra Zeneca, London, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: May
authors.affiliation: Jannsen Research & Development LLC, London, UK.
authors.forename: Lisa
authors.initials: L
authors.lastname: Pierre
authors.affiliation: Jannsen Research & Development LLC, London, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Stevenson
authors.affiliation: Aerocrine AB, Solna, Sweden.
authors.forename: Glenn
authors.initials: G
authors.lastname: Crater
authors.affiliation: Vitalograph Inc, Ennis, Ireland.
authors.forename: Frank
authors.initials: F
authors.lastname: Keane
authors.affiliation: Department of Medicine, Royal College of Surgeons Ireland, Dublin, Ireland.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Costello
authors.affiliation: Public and Patient Representative, London, UK.
authors.forename: Val
authors.initials: V
authors.lastname: Hudson
authors.affiliation: Public and Patient Representative, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Supple
authors.affiliation: Niche Science & Technology, Richmond, UK.
authors.forename: Tim
authors.initials: T
authors.lastname: Hardman
mesh_terms: D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000453:epidemiology*; D035843:Biomedical Research / Q000379:methods*; D019468:Disease Management; D006801:Humans; D010349:Patient Compliance; D018570:Risk Assessment; D006113:United Kingdom
chemical_list: D018927:Anti-Asthmatic Agents
keywords: Asthma Mechanisms