title: p24 family proteins: key players in the regulation of trafficking along the secretory pathway.
abstract: p24 family proteins have been known for a long time, but their functions have remained elusive. However, they are emerging as essential regulators of protein trafficking along the secretory pathway, influencing the composition, structure, and function of different organelles in the pathway, especially the ER and the Golgi apparatus. In addition, they appear to modulate the transport of specific cargos, including GPI-anchored proteins, G-protein-coupled receptors, or K/HDEL ligands. As a consequence, they have been shown to play specific roles in signaling, development, insulin secretion, and the pathogenesis of Alzheimer's disease. The search of new putative ligands may open the way to discover new functions for this fascinating family of proteins.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universitat de València, Avenida Vicente Andrés Estellés, s/n, E-46100, Burjassot, Valencia, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Pastor-Cantizano
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universitat de València, Avenida Vicente Andrés Estellés, s/n, E-46100, Burjassot, Valencia, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Montesinos
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universitat de València, Avenida Vicente Andrés Estellés, s/n, E-46100, Burjassot, Valencia, Spain.
authors.forename: César
authors.initials: C
authors.lastname: Bernat-Silvestre
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universitat de València, Avenida Vicente Andrés Estellés, s/n, E-46100, Burjassot, Valencia, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Marcote
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universitat de València, Avenida Vicente Andrés Estellés, s/n, E-46100, Burjassot, Valencia, Spain. Fernando.aniento@uv.es.
authors.forename: Fernando
authors.initials: F
authors.lastname: Aniento
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D022181:COP-Coated Vesicles / Q000502:physiology; D017124:Conserved Sequence; D019143:Evolution, Molecular; D006801:Humans; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000502:physiology*; D009928:Organ Specificity; D055503:Protein Multimerization; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D059748:Proteolysis
chemical_list: D026901:Membrane Transport Proteins
keywords: COPI- and COPII-coated vesicles; Secretory pathway; p24 protein