title: Additional Therapies to Improve Metastatic Response to Induction Therapy in Children With High-risk Neuroblastoma.
abstract: Children with high-risk neuroblastoma who fail to achieve adequate metastatic response after induction chemotherapy have dismal outcome and new therapeutic strategies are needed. However, timing of introduction of novel agents still remains under discussion. Given an increase in number of phase I-II studies of molecularly targeted drugs in neuroblastoma, it is crucial to determine, as early as possible, which patients may be suitable candidates for new therapeutic strategies. This single-center retrospective analysis of patients with high-risk neuroblastoma showed that the addition of conventional chemotherapy improved the quality of metastatic response only for the group of patients with partial response. It is therefore proposed to develop stratification criteria for those patients very unlikely to benefit from a plethora of additional lines of treatment, but might benefit from introduction of novel agents.
authors.affiliation: *Children and Young People's Unit †Department of Nuclear Medicine & PET/CT, The Royal Marsden NHS Foundation Trust ‡Divisions of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, UK §Clinical Research Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
authors.forename: Dominik
authors.initials: D
authors.lastname: Schrey
authors.forename: Sucheta J
authors.initials: SJ
authors.lastname: Vaidya
authors.forename: Daniel
authors.initials: D
authors.lastname: Levine
authors.forename: Andrew D J
authors.initials: AD
authors.lastname: Pearson
authors.forename: Lucas
authors.initials: L
authors.lastname: Moreno
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D060828:Induction Chemotherapy / Q000401:mortality*; D007223:Infant; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D010865:Pilot Projects; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate