title: Optical coherence tomography-based parameterization and quantification of articular cartilage surface integrity.
abstract: Loss of articular cartilage surface integrity is considered the earliest sign of osteoarthritis; however, its reliable detection has not been established by clinical routine diagnostics. This study comprehensively assesses a set of 11 algorithm-based 2-D Optical Coherence Tomography roughness parameters and investigates their clinical impact. Histology and manual irregularity quantification of 105 human cartilage samples with variable degeneration served as reference. The majority of parameters revealed a close-to-linear correlation with the entire spectrum of degeneration. Surface integrity should therefore be assessed by a combination of parameters to improve current diagnostic accuracy in the determination of cartilage degeneration.
authors.affiliation: Fraunhofer Institute for Production Technology, Aachen, Germany.
authors.forename: Nicolai
authors.initials: N
authors.lastname: Brill
authors.affiliation: Fraunhofer Institute for Production Technology, Aachen, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: Riedel
authors.affiliation: Department of Orthopaedic Surgery, Aachen University Hospital, Aachen, Germany.
authors.forename: Björn
authors.initials: B
authors.lastname: Rath
authors.affiliation: Department of Orthopaedic Surgery, Aachen University Hospital, Aachen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Tingart
authors.affiliation: Department of Orthopaedic Surgery, Aachen University Hospital, Aachen, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Jahr
authors.affiliation: Department of Orthopaedic Surgery, Aachen University Hospital, Aachen, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Betsch
authors.affiliation: Department of Orthopaedic Surgery, Aachen University Hospital, Aachen, Germany.
authors.forename: Valentin
authors.initials: V
authors.lastname: Quack
authors.affiliation: Institute of Anatomy and Cell Biology, RWTH Aachen, Aachen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Pufe
authors.affiliation: Fraunhofer Institute for Production Technology, Aachen, Germany ; Laboratory for Machine Tools and Production Engineering, RWTH Aachen, Aachen, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Schmitt
authors.affiliation: Department of Orthopaedic Surgery, Aachen University Hospital, Aachen, Germany ; Institute of Anatomy and Cell Biology, RWTH Aachen, Aachen, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Nebelung
keywords: (170.1610) Clinical applications; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (170.6935) Tissue characterization