title: Effect of Preoperative Biliary Drainage on Complications Following Pancreatoduodenectomy: A Meta-Analysis.
abstract: Preoperative biliary drainage (PBD) prior to pancreatoduodenectomy (PD) is still controversial; therefore, the aim of this study was to examine the impact of PBD on complications following PD. A meta-analysis was carried out for all relevant randomized controlled trials (RCTs), prospective and retrospective studies published from inception to March 2015 that compared PBD and non-PBD (immediate surgery) for the development of postoperative complications in PD patients. Pooled odds ratio (OR) and 95% confidence interval (CI) were estimated using fixed-effect analyses, or random-effects analyses if there was statistically significant heterogeneity (P < 0.05). Eight RCTs, 13 prospective studies, 20 retrospective studies, and 3 Chinese local retrospective studies with 6286 patients were included in this study. In a pooled analysis, there were no significant differences between PBD and non-PBD group in the risks of mortality, morbidity, intra-abdominal abscess, sepsis, hemorrhage, pancreatic leakage, and biliary leakage. However, subgroup analysis of RCTs yielded a trend toward reduced risk of morbidity in PBD group (OR 0.48, CI 0.24 to 0.97; P = 0.04). Compared with non-PBD, PBD was associated with significant increase in the risk of infectious complication (OR 1.52, CI 1.07 to 2.17; P = 0.02), wound infection (OR 2.09, CI 1.39 to 3.13; P = 0.0004), and delayed gastric emptying (DGE) (OR 1.37, CI 1.08 to 1.73; P = 0.009). This meta-analysis suggests that biliary drainage before PD increased postoperative infectious complication, wound infection, and DGE. In light of the results of the study, PBD probably should not be routinely carried out in PD patients.
authors.affiliation: From the Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation (YC, GL, KH); Department of Gastroenterology (YC, GL, KH), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University; Department of Gastrointestinal Surgery (GO, YH), The Third Affiliated Hospital of Sun Yat-Sen University; and Department of Anesthesiology (HL), The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yinting
authors.initials: Y
authors.lastname: Chen
authors.forename: Guangsheng
authors.initials: G
authors.lastname: Ou
authors.forename: Guoda
authors.initials: G
authors.lastname: Lian
authors.forename: Hui
authors.initials: H
authors.lastname: Luo
authors.forename: Kaihong
authors.initials: K
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
mesh_terms: D004322:Drainage / Q000379:methods*; D006801:Humans; D016577:Pancreaticoduodenectomy / Q000009:adverse effects* / Q000379:methods* / Q000401:mortality; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D013530:Surgical Wound Infection / Q000453:epidemiology