title: Efficient three-component one-pot synthesis of steroidal polysubstituted anilines.
abstract: An efficient and practical base-promoted cascade reaction has been developed to access steroidal polysubstituted anilines from simple precursors. The protocol reported herein achieved the formation of a benzene ring as well as three continuous C-C bonds in a single operation. The reaction mechanism was proposed on the basis of the key intermediate obtained. Besides, this method could be potentially employed for the synthesis of biphenyl compounds. The adjacent amine and nitrile groups existed in the final products have the potential for late stage functionalization, which would provide efficient access to steroidal compound collections with structural diversity and complexity.
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China; College of Chemistry and Chemical Engineering, Xuchang University, Xuchang, Henan Province 461000, PR China.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China.
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China.
authors.forename: Yun-Kai
authors.initials: YK
authors.lastname: Shi
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China.
authors.forename: Guo-Chen
authors.initials: GC
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China.
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: Qi
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China.
authors.forename: Dong-Jun
authors.initials: DJ
authors.lastname: Fu
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China. Electronic address: shlh@zzu.edu.cn.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Shan
authors.affiliation: School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China. Electronic address: liuhm@zzu.edu.cn.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D009570:Nitriles / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000475:Alkenes; D000814:Aniline Compounds; D009570:Nitriles; D013256:Steroids; C000945:dicyanmethane; C023650:aniline
keywords: Cascade reactions; One-pot synthesis; Steroidal anilines