title: Electrochemical Label-Free Nucleotide Sensors.
abstract: Numerous researchers have devoted a great deal of effort over the last few decades to the development of electrochemical oligonucleotide detection techniques, owing to their advantages of simple design, inherently small dimensions, and low power requirements. Their simplicity and rapidity of detection makes label-free oligonucleotide sensors of great potential use as first-aid screening tools in the analytical field of environmental measurements and healthcare management. This review article covers label-free oligonucleotide sensors, focusing specifically on topical electrochemical techniques, including intrinsic redox reaction of bases, conductive polymers, the use of electrochemical indicators, and highly ordered probe structures.
authors.affiliation: Environmental Management Research Institute, National Institute of Advanced Industrial, Science and Technology (AIST), 16-1 Onogawa, Tsukuba, Ibaraki, 305-8569, Japan. aoki-h@aist.go.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aoki
mesh_terms: D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D004566:Electrodes; D007202:Indicators and Reagents / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000032:analysis*; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry; D014173:Transistors, Electronic
chemical_list: D007202:Indicators and Reagents; D009841:Oligonucleotides; D011108:Polymers
keywords: analytical chemistry; electrochemistry; label-free detection; oligonucleotides; sensors