title: Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models.
abstract: We simulate the pathophysiology of severe burn trauma and burn-induced sepsis, using rat models of experimental burn injury and cecal ligation and puncture (CLP) either individually (singe-hit model) or in combination (double-hit model). The experimental burn injury simulates a systemic but sterile pro-inflammatory response, while the CLP simulates the effect of polymicrobial sepsis. Given the liver׳s central role in mediating the host immune response and onset of hypermetabolism after burn injury, elucidating the alterations in hepatic gene expression in response to injury can lead to a better understanding of the regulation of the inflammatory response, whereas circulating cytokine protein expression, reflects key systemic inflammatory mediators. In this article, we present both the hepatic gene expression and circulating cytokine/chemokine protein expression data for the above-mentioned experimental model to gain insights into the temporal dynamics of the inflammatory and hypermetabolic response following burn and septic injury. This data article supports results discussed in research articles (Yang et al., 2012 [1,4]; Mattick et al. 2012, 2013 [2,3]; Nguyen et al., 2014 [5]; Orman et al., 2011, 2012 [6-8]).
authors.affiliation: Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Rohit
authors.initials: R
authors.lastname: Rao
authors.affiliation: Chemical and Biological Engineering Department, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Orman
authors.affiliation: Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Francois
authors.initials: F
authors.lastname: Berthiaume
authors.affiliation: Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA ; Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Ioannis P
authors.initials: IP
authors.lastname: Androulakis
keywords: Burn; Cecal ligation and puncture; Chemokines; Cytokines; Hepatic gene expression; Inflammatory response; Microarray analysis