title: Atomic layer deposition modified track-etched conical nanochannels for protein sensing.
abstract: Nanopore-based devices have recently become popular tools to detect biomolecules at the single-molecule level. Unlike the long-chain nucleic acids, protein molecules are still quite challenging to detect, since the protein molecules are much smaller in size and usually travel too fast through the nanopore with poor signal-to-noise ratio of the induced transport signals. In this work, we demonstrate a new type of nanopore device based on atomic layer deposition (ALD) Al2O3 modified track-etched conical nanochannels for protein sensing. These devices show very promising properties of high protein (bovine serum albumin) capture rate with well time-resolved transport signals and excellent signal-to-noise ratio for the transport events. Also, a special mechanism involving transient process of ion redistribution inside the nanochannel is proposed to explain the unusual biphasic waveshapes of the current change induced by the protein transport.
authors.forename: Ceming
authors.initials: C
authors.lastname: Wang
authors.forename: Qibin
authors.initials: Q
authors.lastname: Fu
authors.affiliation: §School of Advanced Materials, Peking University Shenzhen Graduate School, Shenzhen 518055, People's Republic of China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Wang
authors.affiliation: ∥Laboratory of Plasma Physics and Materials, Beijing Institute of Graphic Communication, Beijing 102600, People's Republic of China.
authors.forename: Delin
authors.initials: D
authors.lastname: Kong
authors.forename: Qian
authors.initials: Q
authors.lastname: Sheng
authors.forename: Yugang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: ∥Laboratory of Plasma Physics and Materials, Beijing Institute of Graphic Communication, Beijing 102600, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.forename: Jianming
authors.initials: J
authors.lastname: Xue
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000295:instrumentation*; D016062:Porosity; D011506:Proteins / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D011506:Proteins; D012710:Serum Albumin, Bovine