title: Cellular prion protein (PrP(C)) and its role in stress responses.
abstract: Investigation of the physiological function of cellular prion protein (PrP(C)) has been developed by the generation of transgenic mice, however, the pathological mechanisms related to PrP(C) in prion diseases such as transmissible spongiform encephalopathies (TSEs) are still abstruse. Regardless of some differences, most studies describe the neuroprotective role of PrP(C) in environmental stresses. In this review, we will update the current knowledge on the responses of PrP(C) to various stresses, especially those correlated with cell signaling and neural degeneration, including ischemia, oxidative stress, inflammation and autophagy.
authors.affiliation: Department of Cardiothoracic Surgery, First Affiliated Hospital, Nanchang University Nanchang 330006, Jiangxi Province, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Department of Neurology, National Prion Disease Pathology Surveillance Center, National Center for Regenerative Medicine, Case Western Reserve University 2085 Adelbert Road, Cleveland, Ohio 44106, USA ; Department of Urology Surgery, First Affiliated Hospital, Nanchang University Nanchang 330006, Jiangxi Province, China.
authors.forename: Wenquan
authors.initials: W
authors.lastname: Zou
authors.affiliation: Department of Urology Surgery, First Affiliated Hospital, Nanchang University Nanchang 330006, Jiangxi Province, China.
authors.forename: Gongxian
authors.initials: G
authors.lastname: Wang
keywords: PrPC; TSE; autophagy; cell survival; inflammation; ischemia; oxidative stress; stress response