title: The association between vitamin D and parathyroid hormone and bone mineral density: the Dong-gu Study.
abstract: The primary objective of the present study was to investigate the relationship between 25-hydroxyvitamin D (25[OH]D) and areal bone mineral density (aBMD) in Korean subjects from the general population aged ≥50 years. This study included 8,857 individuals who completed the baseline survey of the Dong-gu study, which was conducted in Korea from 2007-2010. The participants who fulfilled the detailed inclusion criteria underwent assessment of the femoral neck and lumbar spine aBMD as well as measurement of serum 25(OH)D and parathyroid hormone (PTH) levels. After adjusting for other covariates and log-PTH values, the mean aBMD of the femoral neck exhibited a significant increase with increasing 25(OH)D levels in both males (p < 0.001) and females (p = 0.005). Additionally, the mean aBMD of the lumbar spine exhibited a significant increase with increasing 25(OH)D levels in males (p = 0.011) but not females (p = 0.252). After adjusting for covariates and log-25(OH)D values, the mean aBMD values of the femoral neck and lumbar spine showed significant decreases with increasing PTH levels in both males and females (p < 0.001). The present findings demonstrate that the aBMD of the femoral neck was significantly associated with 25(OH)D levels independent of PTH in both males and females and that the aBMD of the lumbar spine was significantly associated with 25(OH)D levels independent of PTH in males, but not females.
authors.affiliation: Department of Preventive Medicine, Chosun University Medical School, 309, Pilmun-daero, Dong-gu, Gwangju, 501-759, Republic of Korea.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Republic of Korea.|Jeonnam Regional Cancer Center, Chonnam National University Hwasun, Hwasun Hospital, Gwangju, Republic of Korea.
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Republic of Korea.
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Republic of Korea.
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Rhee
authors.affiliation: Department of Preventive Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, 344-2 Shinyong-dong, Iksan, Jeollabukdo, 570-711, Republic of Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, Chungnam National University Medical School, Munhwa 1(il)-dong, Jung-gu, Daejeon, 301-747, Republic of Korea.
authors.forename: Hae-Sung
authors.initials: HS
authors.lastname: Nam
authors.affiliation: Department of Neurology and Research Institute of Clinical Medicine, Chobuk National University-Biomedical Institute of Chonbuk National University Hospital, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeollabukdo, 561-180, Republic of Korea.
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Jeong
authors.affiliation: Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Republic of Korea.
authors.forename: Kyeong-Soo
authors.initials: KS
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Chosun University Medical School, 309, Pilmun-daero, Dong-gu, Gwangju, 501-759, Republic of Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Ryu
authors.affiliation: Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun, Jeollanamdo, 519-809, Republic of Korea.
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Song
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Republic of Korea. mhshinx@paran.com.|Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Republic of Korea. mhshinx@paran.com.|Research Institute of Medical Sciences, Chonnam National University Gwangju, Gwangju, Republic of Korea. mhshinx@paran.com.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
mesh_terms: D000368:Aged; D015519:Bone Density; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011446:Prospective Studies; D056910:Republic of Korea; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Bone mineral density; Parathyroid hormone; Vitamin D