title: Mathematical Modeling of Intravascular Blood Coagulation under Wall Shear Stress.
abstract: Increased shear stress such as observed at local stenosis may cause drastic changes in the permeability of the vessel wall to procoagulants and thus initiate intravascular blood coagulation. In this paper we suggest a mathematical model to investigate how shear stress-induced permeability influences the thrombogenic potential of atherosclerotic plaques. Numerical analysis of the model reveals the existence of two hydrodynamic thresholds for activation of blood coagulation in the system and unveils typical scenarios of thrombus formation. The dependence of blood coagulation development on the intensity of blood flow, as well as on geometrical parameters of atherosclerotic plaque is described. Relevant parametric diagrams are drawn. The results suggest a previously unrecognized role of relatively small plaques (resulting in less than 50% of the lumen area reduction) in atherothrombosis and have important implications for the existing stenting guidelines.
authors.affiliation: National Research Center for Hematology, Moscow, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Russia; Cherkasy National University, Cherkasy, Ukraine.
authors.forename: Oleksii S
authors.initials: OS
authors.lastname: Rukhlenko
authors.affiliation: Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Dudchenko
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: Ksenia E
authors.initials: KE
authors.lastname: Zlobina
authors.affiliation: National Research Center for Hematology, Moscow, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
authors.forename: Georgy Th
authors.initials: GT
authors.lastname: Guria
mesh_terms: D001777:Blood Coagulation; D001808:Blood Vessels / Q000502:physiology* / Q000503:physiopathology; D003251:Constriction, Pathologic / Q000503:physiopathology; D008954:Models, Biological; D058226:Plaque, Atherosclerotic / Q000503:physiopathology; D013314:Stress, Mechanical; D013927:Thrombosis / Q000503:physiopathology