title: Isolation and antitumor efficacy evaluation of a polysaccharide from Nostoc commune Vauch.
abstract: Nostoc commune Vauch. has been traditionally used as a healthy food and medicine for centuries especially in China. It has been demonstrated that the polysaccharides isolated from Nostoc commune Vauch. exhibit strong antimicrobial and antioxidant activities. However, little is known about their anticancer activities and the underlying mechanisms of action. Herein, we report the isolation of a polysaccharide from Nostoc commune Vauch. (NVPS), and its physicochemical properties were analyzed. In an attempt to demonstrate the potential application of NVPS in tumor chemotherapy, the in vitro antitumor activity was determined. NVPS significantly suppressed the growth and proliferation of MCF-7 and DLD1 cells. The molecular mechanism underlying this in vitro antitumor efficacy was elucidated, and the results indicated that NVPS simultaneously triggered intrinsic, extrinsic and endoplasmic reticulum stress (ERS)-mediated apoptotic signaling pathways. Collectively, these findings demonstrate that NVPS could be used as a novel promising source of natural antitumor agents.
authors.affiliation: Institute of Biotechnology, The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, People's Republic of China. lzy@sxu.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Guo
authors.forename: Guo-Bin
authors.initials: GB
authors.lastname: Ding
authors.forename: Songjia
authors.initials: S
authors.lastname: Guo
authors.forename: Zhuoyu
authors.initials: Z
authors.lastname: Li
authors.forename: Liangqi
authors.initials: L
authors.lastname: Zhao
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Guo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D050501:Nostoc commune / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011134:Polysaccharides