title: Optimization of paeonol-loaded microparticle formulation by response surface methodology.
abstract: In this study, a central composite rotatable design based on response surface methodology (RSM) was employed to design and formulate an appropriate paeonol microparticle formulation. Five levels of a three-factor, rotatable, central composite design were used to evaluate the critical formulation variables. The optimum conditions for preparing paeonol-loaded microparticles were predicted to be: polyvinyl alcohol (PVA) content (2.84%), the ratio of drug to polymer (6.88) and the stirring rate (1007.59 rpm). The optimized responses for production yield and loading efficiency were found to be 68.86% and 55.90%, respectively, and the particle size were 23.27 ± 0.76 µm and the sorting coefficient (σ) was 0.732. Furthermore, in vitro release study suggested that microparticle could be a suitable delivery system in treating skin disease for its sustained release of drug. In conclusion, RSM can be successfully used to optimize the effect of formulation variables.
authors.affiliation: a Pharmaceutical Department , the First Affiliated Hospital of Jinan University , Guangzhou , PR China .|b Nanfang Hospital, Southern Medical University , Guangzhou , PR China .
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Li
authors.affiliation: b Nanfang Hospital, Southern Medical University , Guangzhou , PR China .
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Li
authors.affiliation: c School of Traditional Chinese Medicine, Southern Medical University , Guangzhou , PR China , and.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: d Guangzhou Red Cross Hospital , Guangzhou , PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: c School of Traditional Chinese Medicine, Southern Medical University , Guangzhou , PR China , and.
authors.forename: Xiao
authors.initials: X
authors.lastname: Jiang
authors.affiliation: c School of Traditional Chinese Medicine, Southern Medical University , Guangzhou , PR China , and.
authors.forename: Xue-Ling
authors.initials: XL
authors.lastname: Li
authors.affiliation: c School of Traditional Chinese Medicine, Southern Medical University , Guangzhou , PR China , and.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Liu
authors.affiliation: c School of Traditional Chinese Medicine, Southern Medical University , Guangzhou , PR China , and.
authors.forename: Ting
authors.initials: T
authors.lastname: Zuo
authors.affiliation: c School of Traditional Chinese Medicine, Southern Medical University , Guangzhou , PR China , and.
authors.forename: Li-Dong
authors.initials: LD
authors.lastname: Weng
authors.affiliation: c School of Traditional Chinese Medicine, Southern Medical University , Guangzhou , PR China , and.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000098:Acetophenones / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use; D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D053758:Nanoparticles / Q000737:chemistry*; D009824:Ointments; D010316:Particle Size; D011142:Polyvinyl Alcohol; D012871:Skin Diseases / Q000188:drug therapy; D013499:Surface Properties
chemical_list: D000098:Acetophenones; D009824:Ointments; C013638:paeonol; D011142:Polyvinyl Alcohol
keywords: Central composite rotatable design; microparticle; paeonol; particle size; response surface methodology