title: Serum DHEAS levels are associated with the development of depression.
abstract: The aim of study was to evaluate the association between serum DHEAS levels and depression with a case-control study together with a meta-analysis. Radioimmunoassay (RIA) was performed to measure the serum DHEAS levels of all participants before and after treatment. Depression Patients were divided into mild depression and severe depression based on Hamilton depression scale (HAMD24) and received 5-hydroxytryptamine (5-HT) and citalopram (20mg/d) for 8 weeks. Case-control studies related to our study theme were enrolled for meta-analysis and Comprehensive Meta-analysis 2.0 (CMA 2.0) was used for statistical analysis. After treatment, DHEAS levels in depression patients were significantly increased, while before and after treatment, DHEAS levels were all lower in depression patients than in controls (all P<0.001); further analysis on age revealed that DHEAS levels were decreased with the rising of age. Meta-analysis results suggested that serum DHEAS levels (ng/mL) were significantly higher in healthy controls compared to depression patients (SMD=0.777, 95%CI=0.156-1.399, P=0.014). In conclusion, our study suggests that serum DHEAS levels are associated with the development of depression and it decreased with the rising of age.
authors.affiliation: Department of Psychiatry, Shanghai Hongkou District Mental Health Center, Shanghai 200083, PR China. Electronic address: zhuguang790312@163.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Shanghai Changzheng Hospital, Secondary Military Medical University, Shanghai 200003, PR China.
authors.forename: You
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Psychiatry, Shanghai Hongkou District Mental Health Center, Shanghai 200083, PR China.
authors.forename: Chun-Lan
authors.initials: CL
authors.lastname: Xiao
authors.affiliation: Department of Psychiatry, Shanghai Hongkou District Mental Health Center, Shanghai 200083, PR China.
authors.forename: Rong-Jie
authors.initials: RJ
authors.lastname: Mao
authors.affiliation: Department of Psychiatry, Shanghai Hongkou District Mental Health Center, Shanghai 200083, PR China.
authors.forename: Bo-Hai
authors.initials: BH
authors.lastname: Shi
authors.affiliation: Department of Psychiatry, Shanghai Hongkou District Mental Health Center, Shanghai 200083, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Jie
authors.affiliation: Department of Psychiatry, Shanghai Hongkou District Mental Health Center, Shanghai 200083, PR China.
authors.forename: Zuo-Wei
authors.initials: ZW
authors.lastname: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D015283:Citalopram / Q000627:therapeutic use*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012701:Serotonin / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D015283:Citalopram; D012701:Serotonin; D019314:Dehydroepiandrosterone Sulfate
keywords: Case–control study; Dehydroepiandrosterone sulfate; Depression; Meta-analysis; Serum levels