title: Myelination: actin disassembly leads the way.
abstract: The mechanisms that drive the spiral wrapping of the myelin sheath around axons are poorly understood. Two papers in this issue of Developmental Cell demonstrate that actin disassembly, rather than actin assembly, predominates during oligodendrocyte maturation and is critical for the genesis of the central myelin sheath.
authors.affiliation: New York University Neuroscience Institute, Departments of Physiology and Neuroscience, NYU School of Medicine, New York, NY 10016, USA.
authors.forename: Jayshree
authors.initials: J
authors.lastname: Samanta
authors.affiliation: New York University Neuroscience Institute, Departments of Physiology and Neuroscience, NYU School of Medicine, New York, NY 10016, USA. Electronic address: james.salzer@nyumc.org.
authors.forename: James L
authors.initials: JL
authors.lastname: Salzer
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism*; D000818:Animals; D002490:Central Nervous System / Q000254:growth & development*; D009186:Myelin Sheath / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology*
chemical_list: D051376:Actin-Related Protein 2-3 Complex