title: Recurrent ischemic events and risk factors in patients with symptomatic intracranial artery stenosis.
abstract: OBJECTIVE
  To evaluate the recurrent ischemic events and risk factors in patients with symptomatic intracranial artery stenosis.
  
  
  METHODS
  Patients with acute cerebral infarction or transient ischemia attach (TIA) and intracranial arterial stenosis confirmed through CTA examination, were enrolled from the Department of Neurology. All cases were followed-up regularly and divided into recurrent group and non-recurrent group according to occurrence of cerebrovascular events. Major observation index: (1) the occurrence of endpoint; (2) new stroke in responsible artery; (3) drug therapy compliance was used.
  
  
  RESULTS
  A total of 142 cases fulfilled the inclusion criteria, among them 121 cases (85.2%) completed the follow-up, and in 16 cases (13.2%) ischemic cerebrovascular stroke events occurred within one year, while among these vascular lesions recurred on the ipsilateral side in 12 cases (75%). Single factor analysis showed that difference between recurrent group and non-recurrent group on irregular use of statins (p = 0.017), diabetes mellitus (p = 0.017) and severe arterial stenosis (p = 0.030) were statistically significant. Logistic regression analysis showed that irregular use of statins (OR=3.719, p = 0.005), diabetes (OR=1.842. p = 029) and severe arterial stenosis (OR=1.503. p = 0.045) were correlated with the recurrence of symptomatic intracranial artery stenosis.
  
  
  CONCLUSIONS
  Patients with symptomatic intracranial artery stenosis had a higher recurrence rate of stroke; whereas patients with irregular use of statins, diabetes and severe arterial stenosis had a higher recurrence risk of stroke.
authors.affiliation: Department of Neurology, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei, China. zgb1969@126.com.
authors.forename: P-Q
authors.initials: PQ
authors.lastname: Wang
authors.forename: J-J
authors.initials: JJ
authors.lastname: Liu
authors.forename: A-P
authors.initials: AP
authors.lastname: Wang
authors.forename: G-B
authors.initials: GB
authors.lastname: Zhang
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Cao
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.forename: P-Y
authors.initials: PY
authors.lastname: Zhou
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002545:Brain Ischemia / Q000175:diagnosis* / Q000453:epidemiology*; D002536:Cerebral Arteries / Q000473:pathology*; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D000959:Antihypertensive Agents