title: Hydrazones as a privileged structural linker in antitubercular agents: a review.
abstract: Hydrazones are a versatile linker of connecting various classes of organic compounds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. An extensive number of research has been carried out on hydrazone derivatives as a potent class of antitubercular agents. The present review focuses on the chemistry, antitubercular activity and structure activity relationship (SAR) of diverse classes of phenyl and heterocyclic based hydrazones.
authors.affiliation: Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Grace; College of Pharmacy, Palakkad-678004, Kerala, India. bijovilaventgu@gmail.com.
authors.forename: Bijo
authors.initials: B
authors.lastname: Mathew
authors.forename: Jerad
authors.initials: J
authors.lastname: Suresh
authors.forename: Mohamed J
authors.initials: MJ
authors.lastname: Ahsan
authors.forename: Githa E
authors.initials: GE
authors.lastname: Mathew
authors.forename: Dhasthakeer
authors.initials: D
authors.lastname: Usman
authors.forename: Puthucode N S
authors.initials: PN
authors.lastname: Subramanyan
authors.forename: Kallivalappil F
authors.initials: KF
authors.lastname: Safna
authors.forename: Srinubabu
authors.initials: S
authors.lastname: Maddela
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D006835:Hydrazones / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D006835:Hydrazones