title: Anti-Parkinsonian Activity of Hemantane on a Model of Hemiparkinsonian Syndrome in Rats.
abstract: Hemantane demonstrated a pronounced antiparkinsonian activity in the model of hemiparkinsonian syndrome provoked in rats by unilateral intracerebral injection of 6-hydroxydopamine, which was comparable to efficacy of levodopa in decreasing the duration of cataleptogenic state and the degree of akinesia of the contralesional forelimb assessed in the cylinder test. In the stepping test, hemantane exerted a long-term effect in contrast to levodopa, which diminished its beneficial action to the treatment day 21. In the swing test, the behavior normalized only by hemantane.
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia, iwanowaea@yandex.ru.
authors.forename: E A
authors.initials: EA
authors.lastname: Ivanova
authors.forename: I G
authors.initials: IG
authors.lastname: Kapitsa
authors.forename: E A
authors.initials: EA
authors.lastname: Val'dman
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D002375:Catalepsy / Q000188:drug therapy*; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000978:Antiparkinson Agents; C526127:hemantane; D007980:Levodopa; D000218:Adamantane