title: New insights into the architecture of the islet of Langerhans: a focused cross-species assessment.
abstract: The human genome project and its search for factors underlying human diseases has fostered a major human research effort. Therefore, unsurprisingly, in recent years we have observed an increasing number of studies on human islet cells, including disease approaches focusing on type 1 and type 2 diabetes. Yet, the field of islet and diabetes research relies on the legacy of rodent-based investigations, which have proven difficult to translate to humans, particularly in type 1 diabetes. Whole islet physiology and pathology may differ between rodents and humans, and thus a comprehensive cross-species as well as species-specific view on islet research is much needed. In this review we summarise the current knowledge of interspecies islet cytoarchitecture, and discuss its potential impact on islet function and future perspectives in islet pathophysiology research.
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, 637 553, Singapore, Singapore.
authors.forename: Rafael
authors.initials: R
authors.lastname: Arrojo e Drigo
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, 637 553, Singapore, Singapore.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ali
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, 637 553, Singapore, Singapore.
authors.forename: Juan
authors.initials: J
authors.lastname: Diez
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, 637 553, Singapore, Singapore.
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Srinivasan
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, 637 553, Singapore, Singapore. Per-Olof.Berggren@ki.se.|Imperial College London, London, UK. Per-Olof.Berggren@ki.se.|The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital L1, Karolinska Institutet, SE-171 76, Stockholm, Sweden. Per-Olof.Berggren@ki.se.
authors.forename: Per-Olof
authors.initials: PO
authors.lastname: Berggren
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, 637 553, Singapore, Singapore. Bernhard.boehm@ntu.edu.sg.|Imperial College London, London, UK. Bernhard.boehm@ntu.edu.sg.|Department of Internal Medicine 1, Ulm University Medical Centre, Ulm, Germany. Bernhard.boehm@ntu.edu.sg.
authors.forename: Bernhard O
authors.initials: BO
authors.lastname: Boehm
mesh_terms: D000818:Animals; D006801:Humans; D007515:Islets of Langerhans / Q000033:anatomy & histology* / Q000502:physiology*; D013045:Species Specificity
keywords: Cross-species assessment; Intra-islet signalling; Islet cell architecture; Islets of Langerhans; Non-human primates; Review