title: Late Relapse of Testicular Germ Cell Tumors.
abstract: Germ cell tumors of the testis have an overall survival rate greater than 90% as a result of a successful multidisciplinary approach to management. Late relapse affects a subset of patients however, and tends to be chemorefractory and the overall prognosis is poor. Surgery is the mainstay in management of late relapse but salvage chemotherapy can be successful. In this review, the clinical presentation and detection of late relapse, clinical outcomes, and predictors of survival in late relapse and the importance of a multidisciplinary treatment approach for successful management of late relapse are discussed.
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 353 East 68th Street, New York, NY 10065, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: O'Shaughnessy
authors.affiliation: Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 353 East 68th Street, New York, NY 10065, USA.
authors.forename: Darren R
authors.initials: DR
authors.lastname: Feldman
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 353 East 68th Street, New York, NY 10065, USA.
authors.forename: Brett S
authors.initials: BS
authors.lastname: Carver
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 353 East 68th Street, New York, NY 10065, USA. Electronic address: sheinfej@mskcc.org.
authors.forename: Joel
authors.initials: J
authors.lastname: Sheinfeld
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D019468:Disease Management; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D012187:Retroperitoneal Space / Q000473:pathology / Q000601:surgery; D055502:Secondary Prevention; D013736:Testicular Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors
keywords: Germ cell tumor; Late relapse; Retroperitoneal lymph node dissection