title: Preparation of a manganese titanate nanosensor: Application in electrochemical studies of captopril in the presence of para-aminobenzoic acid.
abstract: This study reports the synthesis and characterization of a novel nanostructure-based electrode for electrochemical studies and determination of captopril (CP). At first manganese titanate nanoceramics were synthesized by the sol-gel method. The structural evaluations of the pure nanopowders were investigated by different techniques such as X-ray diffraction (XRD), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). Then it was used to prepare a new nanostructured manganese titanate carbon paste electrode (MnTiO3/CPE). The characterization of the modified sensor was carried out by comprehensive techniques such as electrochemical impedance spectroscopy (EIS), SEM, and voltammetry. Subsequently, the modified electrode was used for CP catalytic oxidation in the presence of para-aminobenzoic acid (PABA) as a mediator. The results showed that PABA has high catalytic activity for CP oxidation. The electrochemical behavior of CP was studied by cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry (CHA), and differential pulse voltammetry (DPV) techniques. Under the optimized conditions, the catalytic oxidation peak current of CP showed two linear dynamic concentration ranges of 1.0 × 10(-8) to 1.0 × 10(-7) and 1.0 × 10(-7) to 1.0 × 10(-6), with a detection limit of 1.6 nM (signal/noise = 3), using the DPV technique. Finally, the proposed method was successfully applied for determination of CP in pharmaceutical and biological samples.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, Islamic Republic of Iran. Electronic address: s.m.ghoreishi@kashanu.ac.ir.
authors.forename: Sayed Mehdi
authors.initials: SM
authors.lastname: Ghoreishi
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, Islamic Republic of Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Karamali
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, Islamic Republic of Iran.
authors.forename: Asma
authors.initials: A
authors.lastname: Khoobi
authors.affiliation: Department of Chemistry, Naragh Branch, Islamic Azad University, Naragh, Islamic Republic of Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Enhessari
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry*; D002216:Captopril / Q000032:analysis*; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods*; D055664:Electrochemical Techniques; D004566:Electrodes; D017895:Manganese Compounds / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D014025:Titanium / Q000737:chemistry*
chemical_list: D017895:Manganese Compounds; D002216:Captopril; D014025:Titanium; D010129:4-Aminobenzoic Acid
keywords: Captopril; Electrochemical studies; Mediator; Nanoceramic; Nanosensor