title: Can blood or follicular fluid levels of presepsin predict reproductive outcomes in ART; a preliminary study.
abstract: Many stages of COH protocols are considered to potentiate a state of systemic inflammation. The limit beyond which inflammation has negative impacts on the formation of conception and the reproductive outcomes are compromised still remains unclear. Presepsin is a novel biomarker for diagnosing systemic inflammation and sepsis. We aimed to investigate whether plasma and follicular fluid presepsin values on oocyte pick-up (OPU) day, embryo transfer (ET) day and pregnancy test (PT) days could predict reproductive outcomes during IVF treatment in women with UEI. Patients were assigned to two groups according to pregnancy test results; pregnant (Group 1) and non-pregnant (Group 2). From all patients included in the study, 2 cc of venous blood was sampled on the three days and follicular fluid (FF) was collected during oocyte retrieval. Plasma presepsin, CRP and WBC values and FF presepsin values were measured and compared between the 2 groups. There was no significant difference between FF and plasma presepsin levels on the OPU day (298±797.4 ve 352.9±657.1; P=0.701, respectively). Plasma WBC, CRP and presepsin levels on the OPU, ET and PT days and FF presepsin levels on OPU day were not different between the 2 groups. Plasma presepsin course on the separate 3 days were different between the groups.
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Educational Hospital Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ovayolu
authors.affiliation: Department of Obstetrics and Gynecology, Gölcük Military Hospital Kocaeli, Turkey.
authors.forename: Özkan
authors.initials: Ö
authors.lastname: Özdamar
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Educational Hospital Istanbul, Turkey.
authors.forename: İsmet
authors.initials: İ
authors.lastname: Gün
authors.affiliation: Department of Microbiology, Zeynep Kamil Training and Educational Hospital Istanbul, Turkey.
authors.forename: Cansev Yılmaz
authors.initials: CY
authors.lastname: Arslanbuga
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Educational Hospital Istanbul, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Sofuoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Educational Hospital Istanbul, Turkey.
authors.forename: Gülden
authors.initials: G
authors.lastname: Tunalı
authors.affiliation: Department of Obstetrics and Gynecology, Istanbul School of Medicine, Istanbul University Istanbul, Turkey.
authors.forename: Samet
authors.initials: S
authors.lastname: Topuz
keywords: C-reactive protein; IVF; Presepsin; follicular fluid; white blood cells