title: Vitamin D in epilepsy: vitamin D levels in epilepsy patients, patients on antiepileptic drug polytherapy and drug-resistant epilepsy sufferers.
abstract: The objective of this study was to assess vitamin D levels in epileptic patients and to compare its serum levels in patients on antiepileptic monotherapy and polytherapy. We analyzed the serum 25-hydroxy (25-OH) vitamin D levels in 98 consecutive subjects (43 epileptic patients and 55 non-epileptics). Factors influencing its serum levels such as degree of sun exposure, physical activity and dietary intake were taken into consideration. Overall, 41% had deficient, 49% had insufficient and 9% had sufficient levels of serum vitamin D. Elderly individuals (>60 years) and people employed in offices and schools had lower blood vitamin D levels. Across both the sexes, epileptic patients and non-epileptics, epileptic patients on monotherapy and polytherapy and patients with drug-responsive and -resistant seizures, there were no significant differences in serum 25-OH vitamin D levels. Our study shows that people with epilepsy suffer with vitamin D deficiency along with their normal peers.
authors.affiliation: Department of Neurology, Guntur Medical College, Government General Hospital, Guntur, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Nagarjunakonda
authors.affiliation: Department of Neurology, Guntur Medical College, Government General Hospital, Guntur, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Amalakanti
authors.affiliation: Department of Neurology, Guntur Medical College, Government General Hospital, Guntur, Andhra Pradesh, India.
authors.forename: V
authors.initials: V
authors.lastname: Uppala
authors.affiliation: Department of Neurology, Guntur Medical College, Government General Hospital, Guntur, Andhra Pradesh, India.
authors.forename: L
authors.initials: L
authors.lastname: Rajanala
authors.affiliation: Department of Neurology, Guntur Medical College, Government General Hospital, Guntur, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Athina
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D000069279:Drug Resistant Epilepsy / Q000097:blood / Q000188:drug therapy; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012016:Reference Values; D013472:Sunlight; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology
chemical_list: D000927:Anticonvulsants; D014807:Vitamin D; C104450:25-hydroxyvitamin D