title: Quantitative Trait Loci Associated with the Tocochromanol (Vitamin E) Pathway in Barley.
abstract: The Genome-Wide Association Studies approach was used to detect Quantitative Trait Loci associated with tocochromanol concentrations using a panel of 1,466 barley accessions. All major tocochromanol types- α-, β-, δ-, γ-tocopherol and tocotrienol- were assayed. We found 13 single nucleotide polymorphisms associated with the concentration of one or more of these tocochromanol forms in barley, seven of which were within 2 cM of sequences homologous to cloned genes associated with tocochromanol production in barley and/or other plants. These associations confirmed a prior report based on bi-parental QTL mapping. This knowledge will aid future efforts to better understand the role of tocochromanols in barley, with specific reference to abiotic stress resistance. It will also be useful in developing barley varieties with higher tocochromanol concentrations, although at current recommended daily consumption amounts, barley would not be an effective sole source of vitamin E. However, it could be an important contributor in the context of whole grains in a balanced diet.
authors.affiliation: Department of Crop and Soil Science, Oregon State University, Corvallis, Oregon, United States of America.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Graebner
authors.affiliation: Cereal Crops Research, USDA-ARS, Madison, Wisconsin, United States of America.
authors.forename: Mitchell
authors.initials: M
authors.lastname: Wise
authors.affiliation: Department of Crop and Soil Science, Oregon State University, Corvallis, Oregon, United States of America.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Cuesta-Marcos
authors.affiliation: Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America.
authors.forename: Matthew
authors.initials: M
authors.lastname: Geniza
authors.affiliation: Plant Sciences and Plant Pathology Department, Montana State University, Bozeman, Montana, United States of America.
authors.forename: Tom
authors.initials: T
authors.lastname: Blake
authors.affiliation: Crop Improvement and Genetics Research, USDA-ARS, Albany, California, United States of America.
authors.forename: Victoria C
authors.initials: VC
authors.lastname: Blake
authors.affiliation: Busch Agricultural Resources, Inc., Fort Collins, Colorado, United States of America.
authors.forename: Joshua
authors.initials: J
authors.lastname: Butler
authors.affiliation: USDA-ARS Cereal Crops Research Unit, Fargo, North Dakota, United States of America.
authors.forename: Shiaomen
authors.initials: S
authors.lastname: Chao
authors.affiliation: Plants, Soils, and Climate Department, Utah State University, Logan, Utah, United States of America.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hole
authors.affiliation: Department of Plant Sciences, North Dakota State University, Fargo, North Dakota, United States of America.
authors.forename: Rich
authors.initials: R
authors.lastname: Horsley
authors.affiliation: Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Jaiswal
authors.affiliation: Limagrain Cereal Seeds, Lafayette, Indiana, United States of America.
authors.forename: Don
authors.initials: D
authors.lastname: Obert
authors.affiliation: Department of Agronomy and Plant Genetics, University of Minnesota, St. Paul, Minnesota, United States of America.
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Smith
authors.affiliation: Department of Crop and Soil Science, Washington State University, Pullman, Washington, United States of America.
authors.forename: Steven
authors.initials: S
authors.lastname: Ullrich
authors.affiliation: Department of Crop and Soil Science, Oregon State University, Corvallis, Oregon, United States of America.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Hayes
mesh_terms: D000483:Alleles; D055106:Genome-Wide Association Study; D001467:Hordeum / Q000235:genetics* / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D014810:Vitamin E