title: Effectiveness of hyaluronic acid in post-tonsillectomy pain relief and wound healing: a prospective, double-blind, controlled clinical study.
abstract: OBJECTIVE
  To find the effectiveness of hyaluronic acid in post-tonsillectomy pain relief and wound healing.
  
  
  METHODS
  Fifty patients were included in this prospective, double-blind, controlled clinical study (20 males, 30 females mean age of 13.56 years). Hyaluronic acid was applied to one side and the other side was used as a control during tonsillectomy. Therefore, the same patient evaluated and scored the post-tonsillectomy pain, excluding individual bias.
  
  
  RESULTS
  Results indicated that patients had significantly lower pain scores for hyaluronic acid treated side (p<0.001). At the end of two weeks follow-up period, the wound in the hyaluronic acid side was almost completely healed, indicating that the healing was faster with hyaluronic acid compared to control side (p<0.001).
  
  
  CONCLUSIONS
  Hyaluronic acid could be recommended as an effective treatment for the management of post-tonsillectomy pain and wound healing.
authors.affiliation: Okmeydanı Education and Research Hospital, ENT Department, Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Hancı
authors.affiliation: Yunus Emre Hospital, ENT Department, Istanbul, Turkey. Electronic address: husdr@yahoo.com.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Altun
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D059408:Pain Management; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D014068:Tonsillectomy / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D006820:Hyaluronic Acid
keywords: Double-blind study; Hyaluronic acid; Pain; Tonsillectomy; Wound healing