title: Serum parathyroid hormone and active vitamin D in chronic periodontitis.
abstract: OBJECTIVE
  To study the association between periodontitis and serum parathyroid hormone (PTH) and the response of PTH to periodontal therapy in type 1 diabetic patients (T1DM). We also investigated the PTH-1,25(OH)2D axis in the T1DM group.
  
  
  METHODS
  Periodontal health status was recorded in 54 periodontitis patients and 30 periodontally healthy controls (case-control data). Data were also collected from patients with type 1 diabetes mellitus at the baseline (n = 76) and after periodontal therapy (intervention data) (n = 53).
  
  
  RESULTS
  Periodontitis was not associated with serum PTH in the case-control data or at the baseline of the intervention data. A post-therapy increase in serum PTH was found in 61% of the T1DM patients; in patients with moderate or severe periodontitis (n = 26) the average increase was 0.6 pmol/l (p = 0.016) and in patients with no or mild periodontitis (n = 27) 0.2 pmol/l (p = 0.250). In 47% of the T1DM patients, an increase in PTH was associated with an increase in serum 1,25(OH)2D.
  
  
  CONCLUSIONS
  An association between serum PTH and periodontal infection was found only after periodontal therapy in T1DM patients. This post-treatment response in serum PTH may partly explain the previously reported increase in serum 1,25(OH)2D.
authors.affiliation: Department of Periodontology and Geriatric Dentistry, Research Group of Oral Health Sciences, University of Oulu, Oulu, Finland.
authors.forename: Georgios N
authors.initials: GN
authors.lastname: Antonoglou
authors.affiliation: Department of Periodontology and Geriatric Dentistry, Research Group of Oral Health Sciences, University of Oulu, Oulu, Finland.|Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Knuuttila
authors.affiliation: Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Tampere, Finland.
authors.forename: Onni
authors.initials: O
authors.lastname: Niemelä
authors.affiliation: Department of Periodontology and Geriatric Dentistry, Research Group of Oral Health Sciences, University of Oulu, Oulu, Finland.|Insitute of Dentistry, University of Eastern Finland, Kuopio, Finland.|Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Pekka
authors.initials: P
authors.lastname: Ylöstalo
authors.affiliation: Specialist Dental Health Care Unit, City of Oulu, Oulu, Finland.
authors.forename: Taina
authors.initials: T
authors.lastname: Raunio
authors.affiliation: Oulu Health Care Center, Oulu, Finland.
authors.forename: Liisa
authors.initials: L
authors.lastname: Hiltunen
authors.affiliation: Institute of Diagnostics, Department of Medical Microbiology and Immunology, University of Oulu, Oulu, Finland.|Department of Bacteriology and Immunology, Haartman Institute, Laboratory Division (HUSLAB), Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
authors.forename: Riitta
authors.initials: R
authors.lastname: Karttunen
authors.affiliation: Department of Periodontology and Geriatric Dentistry, Research Group of Oral Health Sciences, University of Oulu, Oulu, Finland.|Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.
authors.forename: Tellervo
authors.initials: T
authors.lastname: Tervonen
keywords: calcitriol; chronic periodontitis; inflammation; longitudinal studies; parathyroid hormone