title: Independent and combined associations of risky single-occasion drinking and drinking volume with alcohol use disorder: Evidence from a sample of young Swiss men.
abstract: BACKGROUND
  Risky single-occasion drinking (RSOD) is a prevalent and potentially harmful alcohol use pattern associated with increased alcohol use disorder (AUD). However, RSOD is commonly associated with a higher level of alcohol intake, and most studies have not controlled for drinking volume (DV). Thus, it is unclear whether the findings provide information about RSOD or DV. This study sought to investigate the independent and combined effects of RSOD and DV on AUD.
  
  
  METHODS
  Data were collected in the longitudinal Cohort Study on Substance Use Risk Factors (C-SURF) among 5598 young Swiss male alcohol users in their early twenties. Assessment included DV, RSOD, and AUD at two time points. Generalized linear models for binomial distributions provided evidence regarding associations of DV, RSOD, and their interaction.
  
  
  RESULTS
  DV, RSOD, and their interaction were significantly related to the number of AUD criteria. The slope of the interaction was steeper for non/rare RSOD than for frequent RSOD.
  
  
  CONCLUSIONS
  RSOD appears to be a harmful pattern of drinking, associated with increased AUD and it moderated the relationship between DV and AUD. This study highlighted the importance of taking drinking patterns into account, for both research and public health planning, since RSO drinkers constitute a vulnerable subgroup for AUD.
authors.affiliation: Life Course and Social Inequality Research Centre, University of Lausanne, Geopolis Building, CH-1015 Lausanne, Switzerland. Electronic address: stephanie.baggio@unil.ch.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Baggio
authors.affiliation: Institute of Psychology, University of Lausanne, Geopolis Building, CH-1015 Lausanne, Switzerland. Electronic address: marc.depuis@unil.ch.
authors.forename: Marc
authors.initials: M
authors.lastname: Dupuis
authors.affiliation: Centre for the Understanding of Social Processes, University of Neuchâtel, Faubourg de l'Hôpital 27, CH-2000 Neuchâtel, Switzerland. Electronic address: katia.iglesias@unine.ch.
authors.forename: Katia
authors.initials: K
authors.lastname: Iglesias
authors.affiliation: Alcohol Treatment Centre, Lausanne University Hospital CHUV, Av. Beaumont 21 bis, Pavillon 2, CH-1011 Lausanne, Switzerland. Electronic address: Jean-Bernard.Daeppen@chuv.ch.
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Daeppen
mesh_terms: D000428:Alcohol Drinking / Q000453:epidemiology* / Q000523:psychology; D000435:Alcoholic Intoxication; D000437:Alcoholism / Q000453:epidemiology* / Q000523:psychology; D015331:Cohort Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012309:Risk-Taking; D013557:Switzerland / Q000453:epidemiology; D055815:Young Adult
keywords: Cohort study; Internal dysfunction; Longitudinal; Variability of drinking