title: [DNA methylation in thyroid carcinoma].
abstract: Cancer has become clear that not merely gene variations but also epigenetic modifications may contribute to it. Epigenetic changes refer to stable alterations in gene expression with unrelated to changes in the underlying genetic sequence,resulting in heritable. DNA methylation is one of the common epigenetic changes. It control the gene expression through changing DNA conformation and stability, chromatin structer, DNA-protein interaction. The reversal of dysregulated DNA methylation has emerged as a potential strategy for the treatment of thyroid carcinoma. The artical will provide an overview of how DNA methylation contribute to thyroid carcinoma dissemination,invasion and metastasis and we will summarize the latest epigenetic therapies for thyroid carcinoma.
authors.forename: Xianyun
authors.initials: X
authors.lastname: Song
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Shang
authors.forename: Yutuo
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D002843:Chromatin; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015870:Gene Expression; D006801:Humans; D009362:Neoplasm Metastasis; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: D002843:Chromatin