title: Randomized study of different approaches for catheter-directed thrombolysis for lower-extremity acute deep venous thrombosis.
abstract: OBJECTIVE
  To investigate the feasibility, effectiveness, and complications of catheter-directed thrombolysis (CDT) using three different approaches for acute lower-extremity deep venous thrombosis (DVT).
  
  
  METHODS
  A total of 106 patients with acute DVT were enrolled in this study. Forty-one patients received CDT through the small saphenous vein (Group A), 35 through the great saphenous vein (Group B), and 30 through the popliteal vein (Group C). Iliac vein balloon dilation and stenting was performed in 65 cases.
  
  
  RESULTS
  The vascular approach route was not statistically related to limb edema reduction rates (Groups A, B, and C: 82.3 ± 7.6% vs. 81.6 ± 6.0% vs. 83.9 ± 6.1%), nor to thrombolysis rates (63.5 ± 7.7% vs. 66.9 ± 8.4% vs. 66.1 ± 2.7%). The procedure was significantly shorter for Groups B and C. No significant difference was found between Groups B and C. Most complications occurred in Group A. The complication rate in Group B was the lowest. Eighty-eight patients were followed up for 7-24 months. Of these, 78 were pain-free and without limb edema; six showed rethrombosis.
  
  
  CONCLUSIONS
  CDT is an effective method to manage acute DVT. Of the three routes tested, the small saphenous vein route was associated with more frequent complications. Great saphenous vein catheterization was more effective because of its lower complication rate.
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital of Soo Chow University, Suzhou, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Duan
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital of Soo Chow University, Suzhou, China. Electronic address: cjr.nicaifang@vip.163.com.
authors.forename: Cai-Fang
authors.initials: CF
authors.lastname: Ni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D002406:Catheterization, Peripheral / Q000379:methods*; D002681:China; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007084:Iliac Vein / Q000601:surgery; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D011152:Popliteal Vein / Q000601:surgery; D011183:Postoperative Complications; D012501:Saphenous Vein / Q000601:surgery*; D015607:Stents; D015912:Thrombolytic Therapy / Q000379:methods*; D020246:Venous Thrombosis / Q000628:therapy*; D014859:Warfarin / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D014859:Warfarin
keywords: catheter-directed thrombolysis; saphenous vein; stents; venous thrombosis