title: Procognitive Compounds Promote Neurite Outgrowth.
abstract: OBJECTIVE
  To this date, the only available drugs for treating Alzheimer's disease are cognitive enhancers, which may improve the cognitive function of patients for a few years while the disease continues to progress. As such, there are intense investigations to develop disease-modifying drugs to suppress progressive neurodegeneration.
  
  
  METHODS
  In this study, a range of procognitive compounds are tested in a primary neuronal culture to determine their relative potential for promoting neuritogenesis.
  
  
  RESULTS
  We report that donepezil, memantine, dimebon, Pre-084 and 4-IBP are neuritogenic while tacrine, rosemarinic acid, memoquin and a BACE1 inhibitor suppress neurite outgrowth of neurons.
  
  
  CONCLUSIONS
  The results of this study indicate that some procognitive compounds may possess a disease-modifying potential.
authors.affiliation: Translational Bioinformatics, UCB Pharma SA, Slough, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Page
authors.forename: Nathalie
authors.initials: N
authors.lastname: Pacico
authors.forename: Sadia
authors.initials: S
authors.lastname: Ourtioualous
authors.forename: Tania
authors.initials: T
authors.lastname: Deprez
authors.forename: Kyoko
authors.initials: K
authors.lastname: Koshibu
mesh_terms: D000818:Animals; D016501:Neurites / Q000187:drug effects* / Q000648:ultrastructure; D055495:Neurogenesis / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D018697:Nootropic Agents / Q000494:pharmacology*; D061251:Primary Cell Culture; D051381:Rats
chemical_list: D018697:Nootropic Agents