title: [Analysis of Musculoskeletal Systems and Their Diseases. Use of iPS cells in regenerative therapy and drug discovery for cartilage diseases].
abstract: Induced pluripotent stem (iPS) cells can be generated by transiently expressing defined factors in somatic cells such as dermal fibroblasts and blood cells and culturing them in specific medium. iPS cells are expected to provide new tools for research and development of therapies for various diseases because of two important properties : 1) they can be differentiated into any type of somatic cell (pluripotency) and 2) they can be expanded infinitely (self renew). Research for the transplantation of iPS cell-derived cartilage/chondrocytes and drug discovery by iPS cell-based disease modeling are ongoing.
authors.affiliation: Cell Induction and Regulation Field Dept. of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Tsumaki
mesh_terms: D002357:Cartilage Diseases / Q000628:therapy*; D055808:Drug Discovery; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation; D007592:Joint Diseases / Q000628:therapy; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000378:metabolism; D044968:Regenerative Medicine / Q000379:methods
chemical_list: D051498:Receptor, Fibroblast Growth Factor, Type 3