title: MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin.
abstract: Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
authors.affiliation: West CHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
authors.forename: Daniela
authors.initials: D
authors.lastname: Kalafatovic
authors.forename: Max
authors.initials: M
authors.lastname: Nobis
authors.forename: Nadeem
authors.initials: N
authors.lastname: Javid
authors.forename: Pim W J M
authors.initials: PW
authors.lastname: Frederix
authors.forename: Kurt I
authors.initials: KI
authors.lastname: Anderson
authors.forename: Brian R
authors.initials: BR
authors.lastname: Saunders
authors.forename: Rein V
authors.initials: RV
authors.lastname: Ulijn
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D020780:Matrix Metalloproteinase 9 / Q000737:chemistry* / Q000378:metabolism*; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D011108:Polymers; D011092:Polyethylene Glycols; D004317:Doxorubicin; D020780:Matrix Metalloproteinase 9