title: Daily costs of hospitalization in non-valvular atrial fibrillation patients treated with anticoagulant therapy.
abstract: BACKGROUND
  Atrial fibrillation (AF) is the most common cardiac rhythm disturbance in the US, with an estimated prevalence of 2.7-6.1 million persons in 2010.
  
  
  OBJECTIVE
  This study evaluates the progression of daily hospitalization costs among non-valvular atrial fibrillation (NVAF) patients treated with anticoagulant therapy.
  
  
  METHODS
  A claims analysis was conducted with Premier Perspective Comparative Hospital Database records from January 2009-March 2013. Patients of 18 years or older who were diagnosed with NVAF and used anticoagulant therapy were studied. Treatment patterns and mean daily costs of hospitalization per patient as well as total costs of hospitalization were reported. Comparisons of mean daily costs with those of the previous day were presented to identify statistical cost differences between hospitalization days.
  
  
  RESULTS
  A total of 375,560 patients were identified; 67,017 with AF as admitting/primary diagnosis, and 308,543 with AF as a secondary diagnosis. The mean age of the overall population, primary AF diagnosis cohort, and secondary AF diagnosis cohort was 73.8, 67.9, and 75.0 years, while their proportion of females was 46.3%, 45.6%, and 46.5%, respectively. The mean length of stay was 6.8 days, 3.7 days, and 7.5 days for the overall population, the primary AF diagnosis cohort, and the secondary AF diagnosis cohort, respectively. For all cohorts, mean daily costs stabilized on the third day (overall population: $2103; primary AF diagnosis cohort: $1505; secondary AF diagnosis cohort: $2208).
  
  
  CONCLUSIONS
  Claims data may have contained inaccuracies or omissions in coded procedures, diagnoses, or pharmacy claims.
  
  
  CONCLUSIONS
  The study showed that daily hospitalization costs for NVAF patients stabilized on the third day of hospitalization and that any reduction or prolongation in hospital length of stay could have a significant impact on the cost burden associated with AF.
authors.affiliation: a a University of Texas College of Pharmacy , Round Rock , TX , USA.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Dasta
authors.affiliation: b b Groupe d'analyse, Ltée , Montréal , QC , Canada.
authors.forename: Dominic
authors.initials: D
authors.lastname: Pilon
authors.affiliation: c c Janssen Scientific Affairs, LLC , Raritan , NJ , USA.
authors.forename: Samir H
authors.initials: SH
authors.lastname: Mody
authors.affiliation: c c Janssen Scientific Affairs, LLC , Raritan , NJ , USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lopatto
authors.affiliation: b b Groupe d'analyse, Ltée , Montréal , QC , Canada.
authors.forename: François
authors.initials: F
authors.lastname: Laliberté
authors.affiliation: b b Groupe d'analyse, Ltée , Montréal , QC , Canada.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Germain
authors.affiliation: c c Janssen Scientific Affairs, LLC , Raritan , NJ , USA.
authors.forename: Brahim K
authors.initials: BK
authors.lastname: Bookhart
authors.affiliation: b b Groupe d'analyse, Ltée , Montréal , QC , Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Lefebvre
authors.affiliation: d d The University of Illinois at Chicago College of Pharmacy , Chicago , IL , USA.
authors.forename: Edith A
authors.initials: EA
authors.lastname: Nutescu
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000191:economics* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000191:economics*; D005260:Female; D017722:Hospital Charges / Q000706:statistics & numerical data*; D017721:Hospital Costs / Q000706:statistics & numerical data*; D006760:Hospitalization / Q000191:economics; D006801:Humans; D007345:Insurance Claim Review / Q000191:economics / Q000706:statistics & numerical data; D007902:Length of Stay / Q000191:economics; D008297:Male; D010607:Pharmacy Service, Hospital / Q000191:economics*; D012189:Retrospective Studies; D014481:United States
chemical_list: D000925:Anticoagulants
keywords: Atrial fibrillation; Daily costs; Hospitalization