title: Chemotherapy for Good-Risk Nonseminomatous Germ Cell Tumors: Current Concepts and Controversies.
abstract: The rate of diagnosis of germ cell tumors has remained fairly constant. By the International Germ Cell Cancer Consensus Classification, roughly 60% of all metastatic germ cell tumors are classified as good risk. This group of patients has an excellent prognosis, with greater than 90% expectation of cure. Treatment standards have not changed much in recent years. This article focuses on key concepts in the development of the currently accepted first-line regimens and addresses some evolving areas of interest, if not controversy.
authors.affiliation: Division of Medical Oncology, USC Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.
authors.forename: Gino
authors.initials: G
authors.lastname: In
authors.affiliation: Division of Medical Oncology, USC Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. Electronic address: dorff@usc.edu.
authors.forename: Tanya
authors.initials: T
authors.lastname: Dorff
mesh_terms: D000970:Antineoplastic Agents / Q000145:classification / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000145:classification / Q000494:pharmacology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000145:classification / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000517:prevention & control; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D020379:Risk Adjustment; D012307:Risk Factors; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology; D013995:Time
chemical_list: D000970:Antineoplastic Agents
keywords: Bleomycin; Cisplatin; Etoposide; Germ cell tumor