title: Lymphocytic infundibulo-neurohypophysitis: a clinical overview.
abstract: Lymphocytic infundibulo-neurohypophysitis is an uncommon inflammatory disorder postulated to be autoimmune in origin. Because of the location of inflammation, it selectively affects the posterior lobe of the pituitary (neurohypophysis) and pituitary stalk (infundibulum). The most common presentation is central diabetes insipidus. Although the definitive diagnosis is established histologically by a pituitary biopsy, radiological imaging can be valuable in diagnosing this condition. In this paper, we provide an overview of the pathophysiology, investigations, management, and outcomes of lymphocytic infundibulo-neurohypophysitis.
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, 9500 Euclid Avenue Desk F20, Cleveland, OH, 44195, USA. pcjohnston@doctors.org.uk.|Regional Center for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland, UK. pcjohnston@doctors.org.uk.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Johnston
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, 9500 Euclid Avenue Desk F20, Cleveland, OH, 44195, USA.
authors.forename: Luen S
authors.initials: LS
authors.lastname: Chew
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, 9500 Euclid Avenue Desk F20, Cleveland, OH, 44195, USA.|Department of Endocrinology, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
authors.forename: Amir H
authors.initials: AH
authors.lastname: Hamrahian
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, 9500 Euclid Avenue Desk F20, Cleveland, OH, 44195, USA.
authors.forename: Laurence
authors.initials: L
authors.lastname: Kennedy
mesh_terms: D000069281:Autoimmune Hypophysitis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D001706:Biopsy; D006801:Humans; D010902:Pituitary Gland / Q000473:pathology
keywords: Anterior and posterior pituitary function; Central diabetes insipidus; Lymphocytic infundibulo-neurohypophysitis; Pituitary gland