title: Semi-supervised Learning for the BioNLP Gene Regulation Network.
abstract: BACKGROUND
  The BioNLP Gene Regulation Task has attracted a diverse collection of submissions showcasing state-of-the-art systems. However, a principal challenge remains in obtaining a significant amount of recall. We argue that this is an important quality for Information Extraction tasks in this field. We propose a semi-supervised framework, leveraging a large corpus of unannotated data available to us. In this framework, the annotated data is used to find plausible candidates for positive data points, which are included in the machine learning process. As this is a method principally designed for gaining recall, we further explore additional methods to improve precision on top of this. These are: weighted regularisation in the SVM framework, and filtering out unlabelled examples based on a probabilistic rule-finding method. The latter method also allows us to add candidates for negatives from unlabelled data, a method not viable in the unfiltered approach.
  
  
  RESULTS
  We replicate one of the original participant systems, and modify it to incorporate our methods. This allows us to test the extent of our proposed methods by applying them to the GRN task data. We find a considerable improvement in recall compared to the baseline system. We also investigate the evaluation metrics and find several mechanisms explaining a bias towards precision. Furthermore, these findings uncover an intricate precision-recall interaction, depriving recall of its habitual immediacy seen in traditional machine learning set-ups.
  
  
  CONCLUSIONS
  Our contributions are twofold.
authors.forename: Thomas
authors.initials: T
authors.lastname: Provoost
authors.forename: Marie-Francine
authors.initials: MF
authors.lastname: Moens
mesh_terms: D019295:Computational Biology / Q000379:methods; D057225:Data Mining / Q000379:methods*; D053263:Gene Regulatory Networks; D005796:Genes; D006801:Humans; D016247:Information Storage and Retrieval; D000069553:Supervised Machine Learning