title: B cells expressing CD11b effectively inhibit CD4+ T-cell responses and ameliorate experimental autoimmune hepatitis in mice.
abstract: Increasing evidence in recent years has suggested that B cells act as a crucial regulator in autoimmune diseases. However, little is known about their role in autoimmune hepatitis (AIH) and the underlying regulatory mechanisms. In this study, we show that B cells ameliorated experimental AIH (EAH) by suppressing CD4+ T-cell responses and that CD11b expression on B cells was required for the regulatory function of B cells. In vitro studies reveal that the suppressive function of CD11b was mediated by the impairment of T-cell antigen receptor (TCR) signaling transduction and the promotion of TCR down-regulation. Moreover, we show that the increased CD11b expression on B cells was interleukin (IL)-10 dependent and that additional IL-10 stimulation promoted CD11b expression on B cells, thereby enhancing B-cell regulatory effects.
  
  
  CONCLUSIONS
  These findings reveal a previously unrecognized role for CD11b in B-cell regulatory function and its protective effect on EAH.
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Xuechao
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Luman
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Qian
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Yijie
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Enyu
authors.initials: E
authors.lastname: Huang
authors.affiliation: Department of Thoracic Surgery, The Affiliated Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Fengkai
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Ji-Yang
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Center, Fudan University, Shanghai, China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Chu
mesh_terms: D000818:Animals; D018951:Antigens, CD20 / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D039481:CD11b Antigen / Q000032:analysis / Q000502:physiology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D019693:Hepatitis, Autoimmune / Q000276:immunology* / Q000517:prevention & control; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000502:physiology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D018951:Antigens, CD20; D039481:CD11b Antigen; C556062:IL10 protein, mouse; D016753:Interleukin-10; D007371:Interferon-gamma