title: Identifying cancer patients at risk for cardiotoxicity.
abstract: Improvements in therapies have significantly changed survival of cancer patients. However, the clinical history and oncologic treatment put cancer patients at higher risk for developing cardiovascular problems. Anthracyclines, but also the targeted therapy and angiogenesis inhibitors, are all treatments associated with cardiotoxicity. The most common adverse event is a reduction in left ventricular ejection fraction that may progress to overt heart failure. Recognition of a cardiac impairment during or after a potential cardiotoxic treatment requires a stringent assessment of clinical symptoms and signs of heart failure associated with an evaluation of the left ventricular ejection fraction, which, however, detects the damage already installed. Circulating cardiac biomarkers are promising in detecting cardiotoxicity and will likely change the approach for identifying patients at risk.
authors.affiliation: Division of Laboratory Medicine, European Institute of Oncology, via Ripamonti, 435, 20141 Milan, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Salvatici
authors.affiliation: Division of Laboratory Medicine, European Institute of Oncology, via Ripamonti, 435, 20141 Milan, Italy.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Sandri
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins; D057791:Cardiac Imaging Techniques; D066126:Cardiotoxicity / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics; D005260:Female; D037502:Galectin 3 / Q000097:blood; D037161:Galectins; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D045265:Natriuretic Peptides / Q000097:blood; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D057285:Precision Medicine; D012307:Risk Factors; D020107:Troponin T / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human; D045265:Natriuretic Peptides; D020107:Troponin T
keywords: biomarkers; cardio-oncology; cardiotoxicity; cardiovascular damage; chemotherapy; identification