title: Clinical utility of gadoxetate disodium-enhanced hepatic MRI for stereotactic body radiotherapy of hepatocellular carcinoma.
abstract: OBJECTIVE
  To investigate the utility of gadoxetate disodium-enhanced hepatic MRI (EOB-MRI) for stereotactic body radiotherapy (SBRT) to treat hepatocellular carcinoma (HCC).
  
  
  METHODS
  We divided 30 HCC patients who underwent SBRT into group A (no change in their Child-Pugh score 6 months post-SBRT) and group B (increased score 6 months post-SBRT). EOB-MRI was performed before and 6 months after SBRT. We calculated the liver-spleen contrast (LSC) ratio for each radiation dose area on hepatobiliary phase scans (LSCbefore using images obtained before SBRT and LSCafter using images acquired after SBRT) and the weighted LSC (W-LSC) as: [(mean LSCbefore (0-30 Gy) × liver volume (0-30 Gy) + mean LSCbefore (30 Gy-) × liver volume (30 Gy-))/total liver volume]. Then we compared the W-LSC, percentage of the liver volume exposed to >20 Gy (V20), and mean liver dose in the two groups.
  
  
  RESULTS
  The LSCafter at 48, 40, and 30 Gy to the liver was statistically lower than the unirradiated area of the liver (p < 0.01). Univariate analysis showed that only W-LSC was significantly associated with group B (p = 0.02).
  
  
  CONCLUSIONS
  W-LSC was a useful parameter for predicting changes in hepatic function after SBRT.
authors.affiliation: Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. yukon@hiroshima-u.ac.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Radiation Oncology, Hiroshima University, Hiroshima, Japan. tkkimura@hiroshima-u.ac.jp.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. higaki@hiroshima-u.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Higaki
authors.affiliation: Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. honday@hiroshima-u.ac.jp.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Honda
authors.affiliation: Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. komoto@hiroshima-u.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Komoto
authors.affiliation: Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. yamagami@kouchi-u.ac.jp.|Department of Radiology, Kochi University, Kohasu, Oko-Cho, Nankoku, Kouchi, Japan. yamagami@kouchi-u.ac.jp.
authors.forename: Takuji
authors.initials: T
authors.lastname: Yamagami
authors.affiliation: Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. edamako@hiroshima-u.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Iida
authors.affiliation: Radiation Oncology, Hiroshima University, Hiroshima, Japan. nagat@hiroshima-u.ac.jp.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nagata
authors.affiliation: Departments of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan. hyohji@hiroshima-u.ac.jp.|Hiroshima Liver Research Project Center, Hiroshima, Japan. hyohji@hiroshima-u.ac.jp.
authors.forename: Yohji
authors.initials: Y
authors.lastname: Honda
authors.affiliation: Departments of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan. aikata@hiroshima-u.ac.jp.|Hiroshima Liver Research Project Center, Hiroshima, Japan. aikata@hiroshima-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aikata
authors.affiliation: Departments of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan. chayama@hiroshima-u.ac.jp.|Hiroshima Liver Research Project Center, Hiroshima, Japan. chayama@hiroshima-u.ac.jp.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
authors.affiliation: Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. awai@hiroshima-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Awai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D003287:Contrast Media; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D008099:Liver / Q000473:pathology / Q000601:surgery; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gadoxetate disodium; Hepatocellular carcinoma; Magnetic resonance imaging; Stereotactic body radiotherapy