title: Beneficial effect of Omega-3 polyunsaturated fatty acids on neurosensorial impairments and oxidative status in Streptozotocin induced diabetic rats.
abstract: OBJECTIVE
  The present study evaluated the beneficial effects of omega 3 PUFA present in fish oil on neurosensorial impairments, namely learning, memory and anxiety in Streptozotocin (STZ) induced diabetic rats. The brain homogenate was analysed for oxidative status following Omega 3 PUFA treatment.
  
  
  METHODS
  Male, Wistar rats of 2-3 months old were divided into non diabetic controls, diabetic control, & fish oil treated diabetic rats (n = 6). Diabetes was induced by injection of STZ (48 mg/kg, ip). Animals were treated orally for 30 days with a dose in each group of 0.5 g/kg/day of fish oil. All experiments were conducted after ethical committee clearance was obtained.
  
  
  RESULTS
  Memory and exploratory behavior were improved (p < 0.01) in fish oil treated rats as compared with diabetic rats. A significant (p < 0.001) decrease in MDA and a significant increase (p < 0.001) in total antioxidant level (TAO) were observed in fish oil treated rats.
  
  
  CONCLUSIONS
  Omega 3 PUFA present in fish oil could be used an adjuvant therapy for treatment and prevention of neurosensorial impairment in diabetes mellitus.
authors.forename: Saraswati
authors.initials: S
authors.lastname: Yadav
authors.forename: K V
authors.initials: KV
authors.lastname: Mitha
authors.forename: Mamatha T
authors.initials: MT
authors.lastname: Shenoy
authors.forename: Santhosh
authors.initials: S
authors.lastname: Mayannavar
authors.forename: B
authors.initials: B
authors.lastname: Ganaraja
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism / Q000523:psychology; D005106:Exploratory Behavior / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D015227:Lipid Peroxidation; D008297:Male; D008568:Memory / Q000187:drug effects; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D013311:Streptozocin