title: Eosinophils in Gastrointestinal Disorders: Eosinophilic Gastrointestinal Diseases, Celiac Disease, Inflammatory Bowel Diseases, and Parasitic Infections.
abstract: The gastrointestinal (GI) tract provides an intriguing organ for considering the eosinophil's role in health and disease. The normal GI tract, except for the esophagus, is populated by eosinophils that are present throughout the mucosa, raising the possibility that eosinophils participate in innate mechanisms of defense. However, data from clinical studies associates increased numbers of eosinophils with inflammatory GI diseases, prompting concerns that eosinophils may have a deleterious effect on the gut. We present clinical features of 4 disease processes that have been associated with eosinophilia and suggest areas requiring investigation as to their clinical significance and scientific relevance.
authors.affiliation: Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Digestive Health Institute, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Ave B290, Aurora, CO 80045, USA.
authors.forename: Pooja
authors.initials: P
authors.lastname: Mehta
authors.affiliation: Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Digestive Health Institute, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Ave B290, Aurora, CO 80045, USA. Electronic address: glenn.furuta@childrenscolorado.org.
authors.forename: Glenn T
authors.initials: GT
authors.lastname: Furuta
mesh_terms: D000818:Animals; D002446:Celiac Disease / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D004032:Diet; D004751:Enteritis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D004802:Eosinophilia / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D057765:Eosinophilic Esophagitis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D005756:Gastritis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D041981:Gastrointestinal Tract / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D006373:Helminthiasis / Q000469:parasitology / Q000473:pathology; D006376:Helminths / Q000472:pathogenicity; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D007411:Intestinal Diseases, Parasitic / Q000469:parasitology / Q000473:pathology*; D011379:Prognosis
keywords: Eosinophil; Eosinophilic colitis; Eosinophilic esophagitis; Eosinophilic gastritis; Eosinophilic gastroenteritis; Esophagitis; Parasitic infection