title: Riboflavin in cyclic vomiting syndrome: efficacy in three children.
abstract: Cyclic vomiting syndrome is an episodic disorder considered to be a migraine variant. Riboflavin is efficient in the prophylactic treatment of migraines in adults. We describe the effectiveness and tolerance of riboflavin treatment in three children with cyclic vomiting syndrome. All of them fulfilled the diagnosis criteria for cyclic vomiting syndrome. They received prophylactic monotherapy with riboflavin for at least 12 months. Excellent response and tolerability was observed.
  
  
  CONCLUSIONS
  Based on clinical observation in three cases, riboflavin may be an effective and safe prophylactic treatment for children with cyclic vomiting syndrome.
  
  
  BACKGROUND
  CVS is one of the "childhood periodic syndromes" classified as a migraine subtype by the International Headache Society. Riboflavin is currently used as a prophylactic treatment in patients with migraine.
  
  
  BACKGROUND
  Riboflavin may be an effective and safe prophylactic treatment for children with CVS. Increasing doses of riboflavin and long periods of prophylaxis may be needed in some children..
authors.affiliation: Pediatric Neurology, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland. anastasia.martinez-e.melnikova@outlook.com.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Martinez-Esteve Melnikova
authors.affiliation: Pediatric Gastroenterology, Grangettes Clinic, Geneva, Switzerland. michela.tempia@grangettes.ch.
authors.forename: Michela G
authors.initials: MG
authors.lastname: Schäppi
authors.affiliation: Pediatric Neurology, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland. Christian.Korff@hcuge.ch.
authors.forename: Christian
authors.initials: C
authors.lastname: Korff
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012256:Riboflavin / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use*; D014839:Vomiting / Q000188:drug therapy*
chemical_list: D014803:Vitamin B Complex; D012256:Riboflavin
keywords: Children; Cyclic vomiting syndrome; Migraine; Periodic syndromes; Riboflavin