title: A rapid and sensitive assay for determination of doxycycline using thioglycolic acid-capped cadmium telluride quantum dots.
abstract: A rapid, simple and inexpensive spectrofluorimetric sensor for determination of doxycycline based on its interaction with thioglycolic acid-capped cadmium telluride quantum dots (TGA/CdTe QDs) has been developed. Under the optimum experimental conditions, the sensor exhibited a fast response time of <10s. The results revealed that doxycycline could quench the fluorescence of TGA/CdTe QDs via electron transfer from the QDs to doxycycline through a dynamic quenching mechanism. The sensor permitted determination of doxycycline in a concentration range of 1.9×10(-6)-6.1×10(-5)molL(-1) with a detection limit of 1.1×10(-7)molL(-1). The sensor was applied for determination of doxycycline in honey and human serum samples.
authors.affiliation: Professor Massoumi Laboratory, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran. Electronic address: tashkhourian@susc.ac.ir.
authors.forename: Javad
authors.initials: J
authors.lastname: Tashkhourian
authors.affiliation: Professor Massoumi Laboratory, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: Ghodratollah
authors.initials: G
authors.lastname: Absalan
authors.affiliation: Professor Massoumi Laboratory, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Jafari
authors.affiliation: Professor Massoumi Laboratory, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: Saber
authors.initials: S
authors.lastname: Zare
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000097:blood*; D019187:Cadmium Compounds / Q000737:chemistry*; D004318:Doxycycline / Q000032:analysis* / Q000097:blood*; D006722:Honey / Q000032:analysis; D006801:Humans; D057230:Limit of Detection; D045663:Quantum Dots / Q000737:chemistry* / Q000648:ultrastructure; D013050:Spectrometry, Fluorescence / Q000379:methods; D013691:Tellurium / Q000737:chemistry*; D013864:Thioglycolates / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D019187:Cadmium Compounds; D013864:Thioglycolates; C017487:2-mercaptoacetate; D004318:Doxycycline; D013691:Tellurium; C028337:cadmium telluride
keywords: Cadmium telluride quantum dots; Doxycycline; Fluorescence detection; Sonochemical synthesis