title: Phylogenetic analysis and forensic characteristics of 12 populations using 23 Y-STR loci.
abstract: Genetic analysis of Y-STRs has the potential to be used to explore the complexity in population substructures and to perform forensic ancestry inference. In this study, 334 individuals from 12 populations were typed using the PowerPlex(®) Y23 System (Promega, USA) to investigate their relationship. Population comparisons with other East Asian populations collated from YHRD (Y-STR Haplotype Reference Database) were also performed. Variant alleles, including seven intermediate alleles in 15 samples were observed, while the novel allele 11.3 at the DYS549 locus was confirmed by sequencing. Our results showed that the fraction of unique haplotypes differed among the 12 populations studied here. A close relationship was found between Chinese and other East Asian populations. The present study contributed to the enrichment of the forensic Y-chromosome databases with a high resolution 23 Y-STR marker set, which is informative in forensic casework, such as familial searching and estimating the geographical origin of the offender.
authors.affiliation: Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Tianzhen
authors.initials: T
authors.lastname: Gao
authors.affiliation: Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Libing
authors.initials: L
authors.lastname: Yun
authors.affiliation: Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Wang
authors.initials: W
authors.lastname: He
authors.affiliation: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, PR China, Shanghai 200063, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: prof.hou@gmail.com.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000483:Alleles; D041322:Chromosomes, Human, Y; D053803:Forensic Genetics; D006239:Haplotypes; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D010802:Phylogeny
keywords: Forensics; Haplotypes; Population data; PowerPlex(®) Y23; Y-chromosome