title: Potential Antiviral Agents from Marine Fungi: An Overview.
abstract: Biodiversity of the marine world is only partially subjected to detailed scientific scrutiny in comparison to terrestrial life. Life in the marine world depends heavily on marine fungi scavenging the oceans of lifeless plants and animals and entering them into the nutrient cycle by. Approximately 150 to 200 new compounds, including alkaloids, sesquiterpenes, polyketides, and aromatic compounds, are identified from marine fungi annually. In recent years, numerous investigations demonstrated the tremendous potential of marine fungi as a promising source to develop new antivirals against different important viruses, including herpes simplex viruses, the human immunodeficiency virus, and the influenza virus. Various genera of marine fungi such as Aspergillus, Penicillium, Cladosporium, and Fusarium were subjected to compound isolation and antiviral studies, which led to an illustration of the strong antiviral activity of a variety of marine fungi-derived compounds. The present review strives to summarize all available knowledge on active compounds isolated from marine fungi with antiviral activity.
authors.affiliation: Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. soheil.zorofchian@gmail.com.
authors.forename: Soheil Zorofchian
authors.initials: SZ
authors.lastname: Moghadamtousi
authors.affiliation: Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. sonia.nikzad@gmail.com.
authors.forename: Sonia
authors.initials: S
authors.lastname: Nikzad
authors.affiliation: Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. habsah@um.edu.my.
authors.forename: Habsah Abdul
authors.initials: HA
authors.lastname: Kadir
authors.affiliation: Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. sazaly@um.edu.my.
authors.forename: Sazaly
authors.initials: S
authors.lastname: Abubakar
authors.affiliation: Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. keivan@um.edu.my.|The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr 75169, Iran. keivan@um.edu.my.
authors.forename: Keivan
authors.initials: K
authors.lastname: Zandi
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry*; D006678:HIV / Q000187:drug effects; D006801:Humans; D008977:Molluscum contagiosum virus / Q000187:drug effects; D009975:Orthomyxoviridae / Q000187:drug effects; D019316:Porcine respiratory and reproductive syndrome virus / Q000187:drug effects; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D014027:Tobacco Mosaic Virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents
keywords: antiviral; marine fungi; natural products; review