title: Lessons learned from studies with the growth hormone receptor.
abstract: Findings related to GH's biological activities have continued to be a fascinating topic over the past decade. Below, I will review several items related to the actions of GH including the GH/GHR interaction, pegvisomant (a GH receptor antagonist), GHR gene disruptions in mice, and clinical consequences of human GHR gene mutations.
authors.affiliation: Growth Hormone Research Society, Edison Biotechnology Institute & Dept. of Biomedical Sciences, HCOM, Ohio University, Athens, OH 45701, United States. Electronic address: kopchick@ohio.edu.
authors.forename: John J
authors.initials: JJ
authors.lastname: Kopchick
mesh_terms: D000172:Acromegaly / Q000188:drug therapy; D000818:Animals; D013006:Growth Hormone / Q000378:metabolism*; D019382:Human Growth Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009154:Mutation; D011986:Receptors, Somatotropin / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D013006:Growth Hormone; C406545:pegvisomant
keywords: Growth hormone receptor; Growth hormone receptor gene disruptions; Pegvisomant