title: Effects of combination of whey protein intake and rehabilitation on muscle strength and daily movements in patients with hip fracture in the early postoperative period.
abstract: Elderly patients can be at risk of protein catabolism and malnutrition in the early postoperative period. Whey protein includes most essential amino acids and stimulates the synthesis of muscle protein. The purpose of this study was to investigate the effect of resistance training in combination with whey protein intake in the early postoperative period.
  
  
  
  We randomized patients to a whey protein group or a control group. The former group received 32.2 g of whey protein pre- and post-rehabilitation in the early postoperative period for two weeks. Outcomes were knee extension strength on either side by Biodex 4.0, and the ability of transfer, walking, toilet use and stair use by the Barthel Index (BI). We performed initial and final assessments in the second and tenth rehabilitation sessions.
  
  
  
  A total of 38 patients were recruited: 20 in the whey protein group and 18 in the control group. Participants in the whey protein group showed significantly greater improvement in knee extension strength in the operated limb compared with the control group (F = 6.11, P = 0.02). The non-operated limb also showed a similar tendency (F = 3.51, P = 0.07). The abilities of transfer, walking and toilet use showed greater improvements in the whey protein group than in the control group by BI (P < 0.05).
  
  
  
  The combination of whey protein intake and rehabilitation for two weeks in the early postoperative period has a beneficial effect on knee extension strength in both lower limbs and BI (transfer, walking and toilet use) scores in patients with hip fracture.
authors.affiliation: Department of Rehabilitation, Iwata City Hospital, 512-3 Okubo-machi, Iwata-shi, Shizuoka, Japan. Electronic address: 11mr09@g.seirei.ac.jp.
authors.forename: Masaya
authors.initials: M
authors.lastname: Niitsu
authors.affiliation: Department of Rehabilitation, Iwata City Hospital, 512-3 Okubo-machi, Iwata-shi, Shizuoka, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichinose
authors.affiliation: Department of Rehabilitation, Iwata City Hospital, 512-3 Okubo-machi, Iwata-shi, Shizuoka, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Hirooka
authors.affiliation: Department of Rehabilitation, Iwata City Hospital, 512-3 Okubo-machi, Iwata-shi, Shizuoka, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Mitsutomi
authors.affiliation: Department of Orthopedic Surgery, Iwata City Hospital, 512-3 Okubo-machi, Iwata-shi, Shizuoka, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Morimoto
authors.affiliation: Department of Orthopedic Surgery, Iwata City Hospital, 512-3 Okubo-machi, Iwata-shi, Shizuoka, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Sarukawa
authors.affiliation: Department of Orthopedic Surgery, Wakamatsu Hospital of the University of Occupational and Environmental Health, 1-ban 1-go Iseigaoka, Yahatanishi-ku, Kitakyushu-shi, Fukuoka, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Nishikino
authors.affiliation: Department of Rehabilitation Medicine, Hamamatsu University School of Medicine University Hospital, 1-20-1 Handayama, Hamamatsu-shi, Higashi-ku, Shizuoka, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: Department of Orthopedic Surgery, Iwata City Hospital, 512-3 Okubo-machi, Iwata-shi, Shizuoka, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamazaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006620:Hip Fractures / Q000534:rehabilitation* / Q000601:surgery; D006801:Humans; D053580:Muscle Strength / Q000187:drug effects*; D011184:Postoperative Period; D055070:Resistance Training; D016896:Treatment Outcome; D016138:Walking; D000067816:Whey Proteins / Q000008:administration & dosage*
chemical_list: D000067816:Whey Proteins; D002097:C-Reactive Protein
keywords: Early postoperative period; Hip fracture; Whey protein