title: Immature dendritic cell exosomes suppress experimental autoimmune myasthenia gravis.
abstract: Immature dendritic cell-derived exosomes (iMDEX) display a certain degree of immunosuppressive activity in autoimmune diseases. However, the role of iMDEX in experimental autoimmune myasthenia gravis (EAMG) is still unclear. Therefore, we tested the effects of mouse bone marrow (BM)-derived iMDEX on tolerance induction in a mouse model of EAMG. In this study, we found that the CELLine culture system produced more exosomes, the morphology and phenotype of these exosomes were found to be identical when compared with traditional cell culture. And, iMDEX(1000) ameliorated the progression of EAMG by reducing AChR-reactive lymphocyte proliferation, AChR antibody levels and pro-inflammatory cytokine levels.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China. Electronic address: ningbuxa@163.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Bu
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Hai-Qin
authors.initials: HQ
authors.lastname: Wu
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Gui-Lian
authors.initials: GL
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Shu-Qin
authors.initials: SQ
authors.lastname: Zhan
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Ru
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Qing-Yu
authors.initials: QY
authors.lastname: Fan
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Li
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Yue-Fan
authors.initials: YF
authors.lastname: Zhai
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Ren
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D055354:Exosomes / Q000276:immunology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D020720:Myasthenia Gravis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*
keywords: Exosomes; Experimental autoimmune myasthenia gravis (EAMG); Immature dendritic cell (iMDC)