title: MECHANISMS OF THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS.
abstract: Thrombotic events are highly prevalent in systemic lupus erythematosus (SLE). Antiphospholipid antibodies play an essential role in promoting thrombosis by activating several intracellular signaling pathways (TLR4, p38MAPK, NFkB) in platelets, monocytes and endothelial cells. New therapeutic opportunities might be offered by addressing these molecular targets. Chronic inflammatory status, the degree of disease activity and accelerated atherosclerosis are also responsible for the thrombotic phenotype in patients with SLE. The aim of this review is to highlight thrombosis mechanisms and to look for possible connection between SLE, antiphospholipid antibodies and cancer, especially myeloproliferative neoplasms.
authors.forename: Adriana
authors.initials: A
authors.lastname: Metoni
authors.forename: Cristina
authors.initials: C
authors.lastname: Mambet
authors.forename: Laura G
authors.initials: LG
authors.lastname: Necula
authors.forename: Ioana M
authors.initials: IM
authors.lastname: Aldea
authors.forename: Ana I
authors.initials: AI
authors.lastname: Neagu
authors.forename: Lilia
authors.initials: L
authors.lastname: Matei
authors.forename: Denisa
authors.initials: D
authors.lastname: Dragu
authors.forename: Coralia
authors.initials: C
authors.lastname: Bleotu
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Ion
authors.forename: Carmen C
authors.initials: CC
authors.lastname: Diaconu
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D013927:Thrombosis / Q000209:etiology*
chemical_list: D017152:Antibodies, Antiphospholipid