title: Role of 5-HT(2B) Serotonin Receptor Agonist in the Regulation of Pumping Function of the Heart.
abstract: The effect of α-methyl-5-hydroxytryptamine maleate, an agonist of 5-HT2B serotonin receptors, on the pumping function of the heart was examined in rats with forced motor behavior. At rest, swim-trained rats demonstrated lower HR and greater stroke volume and cardiac output than untrained rats. The agonist decreased HR, stroke volume, and cardiac output in 21- and 70-day-old swim-trained rats, but not in 100- and 200-day-old rats.
authors.affiliation: Kazan Federal University, Kazan, Russia, abzalov2004@mail.ru.
authors.forename: R A
authors.initials: RA
authors.lastname: Abzalov
authors.forename: R R
authors.initials: RR
authors.lastname: Abzalov
authors.forename: A M
authors.initials: AM
authors.lastname: Valeev
authors.forename: N I
authors.initials: NI
authors.lastname: Abzalov
authors.forename: A A
authors.initials: AA
authors.lastname: Gulyakov
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D058826:Serotonin 5-HT2 Receptor Agonists; C042390:alpha-methylserotonin; D012701:Serotonin