title: Analysis of Association Between the Insertion Location of Iris Root and Narrow Angle.
abstract: OBJECTIVE
  To study the association between the insertion location of iris root and narrow angle.
  
  
  METHODS
  This was a prospective observational study. A total of 142 eyes of 142 subjects were recruited, including 78 with narrow angles and 64 normals. All participants underwent ultrasound biomicroscopy and customized software was used to quantitatively analyze the images. An eye was considered to have narrow angle if there was iridotrabecular contact for at least 180 degrees on nonindentation gonioscopy in the primary position. The difference in various parameters between subjects with narrow angle and normal controls were analyzed. The association between the distance from the iris root to scleral spur (IrisD) and angle open distance was also analyzed.
  
  
  RESULTS
  Significant differences between narrow angle and normal eyes were found for anterior chamber depth (ACD, 2.01±0.26 vs. 2.66±0.34 mm, P≤0.001), anterior chamber width (ACW, 10.96±0.45 vs. 11.19±0.39 mm, P=0.003), IrisD (0.083±0.091 vs. 0.174±0.094 mm, P<0.001), and iris thickness at 1500 µm from the scleral spur (IT1500, 0.533±0.087 vs. 0.503±0.081 mm, P=0.007). After adjusting for age, sex, ACD, ACW, and IT1500, a smaller IrisD was associated significantly with narrow angle (odds ratio, 104.3; 95% confidence interval, 5.9-1852, comparing highest with lowest quartile). In terms of distinguishing narrow angle subjects from open angle subjects, IrisD [area under the receiver operator characteristic curve (AUC) 0.76] performed relatively poorer compared with ACD (AUC 0.95).
  
  
  CONCLUSIONS
  A smaller distance from iris root to scleral spur was associated with the presence of narrow angle.
authors.affiliation: *Department of Ophthalmology, Beijing Shijitan Hospital, Capital University of Medical Sciences, Beijing, China †Singapore Eye Research Institute, Singapore National Eye Centre ‡Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Bingsong
authors.initials: B
authors.lastname: Wang
authors.forename: Monisha E
authors.initials: ME
authors.lastname: Nongpiur
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Dong
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
mesh_terms: D000368:Aged; D000867:Anterior Chamber / Q000000981:diagnostic imaging*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000000981:diagnostic imaging* / Q000473:pathology; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D012590:Sclera / Q000473:pathology; D041623:Tomography, Optical Coherence