title: Do diethyl phthalate (DEP) and di-2-ethylhexyl phthalate (DEHP) influence the metabolic syndrome parameters? Pilot study.
abstract: The study objective was to determine if the healthy participants were exposed to diethyl phthalate (DEP) and di (2-ethylhexyl) phthalate (DEHP) and if this exposure could be linked to the development of metabolic syndrome. The study included 103 healthy volunteers of similar age with normal BMI values, waist circumference, total cholesterol, HDL, LDL, and triglycerides. DEP and DEHP were measured in the morning urine samples to detect monoethyl phthalate (MEP) and mono-2-ethylhexyl phthalate (MEHP). Two phthalate groups and a control group were formed. Both MEP group and control group had similar results. The correlations between MEP and the measured parameters were insignificant. The correlation between the MEHP group and the age was significantly negative, but between the MHEP group and the waist circumference the correlation was significantly positive. Lipids and lipoproteins were within the reference values and equal in both groups. The significant negative correlation was observed only between MEHP and HDL. Our population is exposed to DEP and DEHP. There was only a significant correlation between DEHP and the observed metabolic syndrome components. Its negative impact was higher as the participants were younger.
authors.affiliation: Faculty of Medicine, Clinical Centre of Vojvodina, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University of Novi Sad, Hajduk Veljkova 1, 21000, Novi Sad, Serbia, milica.medic1@gmail.com.
authors.forename: Milica
authors.initials: M
authors.lastname: Medic Stojanoska
authors.forename: Andrijana
authors.initials: A
authors.lastname: Milankov
authors.forename: Bojan
authors.initials: B
authors.lastname: Vukovic
authors.forename: Dejan
authors.initials: D
authors.lastname: Vukcevic
authors.forename: Jan
authors.initials: J
authors.lastname: Sudji
authors.forename: Ivana
authors.initials: I
authors.lastname: Bajkin
authors.forename: Nikola
authors.initials: N
authors.lastname: Curic
authors.forename: Tijana
authors.initials: T
authors.lastname: Icin
authors.forename: Branka
authors.initials: B
authors.lastname: Kovacev Zavisic
authors.forename: Natasa
authors.initials: N
authors.lastname: Milic
mesh_terms: D000328:Adult; D004051:Diethylhexyl Phthalate / Q000031:analogs & derivatives* / Q000652:urine; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000209:etiology*; D010795:Phthalic Acids / Q000652:urine*; D010865:Pilot Projects; D055105:Waist Circumference
chemical_list: D008055:Lipids; D010795:Phthalic Acids; C581825:monoethyl phthalate; D004051:Diethylhexyl Phthalate; C016599:mono-(2-ethylhexyl)phthalate; C007379:diethyl phthalate