title: The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription.
abstract: BACKGROUND
  The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection.
  
  
  RESULTS
  We found that SsnB treatment blocked HIV-1 transcription via a novel mechanism that requires the TAR region. Treatment of human T cell lines or peripheral blood mononuclear cells with SsnB at 1 μM significantly inhibited HIV production. Lastly, SsnB was able to inhibit HIV in synergy with AZT.
  
  
  CONCLUSIONS
  These data suggest that SsnB is a novel natural compound that inhibits HIV-1 transcription and may be a new drug in the treatment of HIV infection.
authors.affiliation: Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. 260446391@qq.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. 1067545641@qq.com.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. 2753933363@qq.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. ranchen86@163.com.
authors.forename: Ran
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. pcpeng66@163.com.
authors.forename: Peichun
authors.initials: P
authors.lastname: Peng
authors.affiliation: Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. 286449737@qq.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Wen
authors.affiliation: Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. Dr_JianLiang@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Liang
mesh_terms: D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D004357:Drug Synergism; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects / Q000821:virology; D014158:Transcription, Genetic / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D001688:Biological Products; D006576:Heterocyclic Compounds, 4 or More Rings; C561322:sparstolonin B; D015215:Zidovudine