title: Host-pathogen interactions in malaria: cross-kingdom signaling and mitochondrial regulation.
abstract: Malaria parasite-host interactions are complex and have confounded available drugs and the development of vaccines. Further, we now appreciate that interventions for malaria elimination and eradication must include therapeutics with intrinsic transmission blocking activity to treat the patient and prevent disease spread. Studies over the past 15 years have revealed significant conservation in the response to infection in mosquito and human hosts. More recently, we have recognized that conserved cell signaling cascades in mosquitoes and humans dictate infection outcome through the regulation of mitochondrial function and biogenesis, which feed back to host immunity, basic intermediary metabolism, and stress responses. These responses - reflected clearly in the primeval insect host - provide fertile ground for innovative strategies for both treatment and transmission blocking.
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis CA 95616, United States. Electronic address: sluckhart@ucdavis.edu.
authors.forename: Shirley
authors.initials: S
authors.lastname: Luckhart
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis CA 95616, United States.
authors.forename: Nazzy
authors.initials: N
authors.lastname: Pakpour
authors.affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, and Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, Davis CA 95616, United States.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Giulivi
mesh_terms: D000818:Animals; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008288:Malaria / Q000276:immunology* / Q000378:metabolism* / Q000469:parasitology; D008928:Mitochondria / Q000378:metabolism; D010961:Plasmodium / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D013002:Somatomedins / Q000378:metabolism
chemical_list: D007328:Insulin; D013002:Somatomedins; D011494:Protein Kinases