title: Hydroxytyrosol-Derived Compounds: A Basis for the Creation of New Pharmacological Agents for Cancer Prevention and Therapy.
abstract: Hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol, HTyr] is a phenolic compound found in olive leaves and fruits and extra-virgin olive oil, which has well-known strong antioxidant and radical-scavenging properties. Recently, it has received particular attention for its antiproliferative and apoptotic activities and its anti-inflammatory properties. During the past few years, more efforts have been focused on synthesizing HTyr-derived compounds with enhanced biological activities for their potential use in different chronic degenerative diseases. In this paper, we report a dissertation on the current knowledge of selected synthetic HTyr derivatives and analogues and their potential use in cancer prevention and therapy, which are related to their antioxidant, antiproliferative/apoptotic, and anti-inflammatory properties. On the basis of the perspective of using HTyr-derived compounds as anticancer agents, we have taken into account only studies that were performed in experimental cell-based models.
authors.affiliation: Department of Agriculture, Nature, Forests and Energy (DAFNE), Tuscia University , Via S. Camillo De Lellis, 01100 Viterbo, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Bernini
authors.affiliation: Department of Experimental Medicine, Sapienza University of Rome , 00161 Rome, Italy.
authors.forename: Maria Saveria
authors.initials: MS
authors.lastname: Gilardini Montani
authors.affiliation: Department of Ecological and Biological Sciences (DEB), Tuscia University , 01100 Viterbo, Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Merendino
authors.affiliation: PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement Technology and Analysis)-DISIA, University of Florence , 50134 Florence, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Romani
authors.affiliation: Department of Ecological and Biological Sciences (DEB), Tuscia University , 01100 Viterbo, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Velotti
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D055808:Drug Discovery; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D000069463:Olive Oil / Q000737:chemistry; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D000069463:Olive Oil; C005975:3,4-dihydroxyphenylethanol; D010626:Phenylethyl Alcohol