title: [Amerindian admixture estimation based on serological and molecular methods].
abstract: BACKGROUND
  Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls.
  
  
  OBJECTIVE
  To compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population.
  
  
  METHODS
  Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABO*O and ABO*A alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNPs).
  
  
  RESULTS
  Mean admixture estimates obtained using ABO*O and ABO*A alleles and AIMs were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABO*O allele and AIMs.
  
  
  CONCLUSIONS
  In Chile, Amerindian admixture estimates obtained using ABO*A could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.
authors.forename: Iván
authors.initials: I
authors.lastname: Pulgar-Alarcón
authors.forename: Macarena
authors.initials: M
authors.lastname: Fuentes-Guajardo
authors.forename: Elena
authors.initials: E
authors.lastname: Llop
authors.forename: Francisco
authors.initials: F
authors.lastname: Rothhammer
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D002677:Chile / Q000208:ethnology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015203:Reproducibility of Results; D044465:White People / Q000235:genetics*
chemical_list: D000017:ABO Blood-Group System; D005819:Genetic Markers