title: Epstein-Barr virus association with peptic ulcer disease.
abstract: Background. Helicobacter pylori (HP) infection and nonsteroidal anti-inflammatory drugs (NSAID) use are considered the main risk to develop peptic ulcer disease (PUD). However, PUD also occurs in the absence of HP infection and/or NSAID use. Recently, we have found evidence that Epstein-Barr virus (EBV) reactivation increases the risk to develop premalignant and malignant gastric lesions. Objective. To study a possible association between EBV and PUD. Methods. Antibodies against an EBV reactivation antigen, HP, and the HP virulence factor CagA were measured in sera from 207 Mexican subjects, controls (healthy individuals, n = 129), and PUD patients (n = 78, 58 duodenal and 20 gastric ulcers). Statistical associations were estimated. Results. Duodenal PUD was significantly associated with high anti-EBV IgG titers (p = 0.022, OR = 2.5), while anti-EBV IgA was positively associated with gastric PUD (p = 0.002, OR = 10.1). Conclusions. Our study suggests that EBV reactivation in gastric and duodenal epithelium increases the risk to develop PUD.
authors.affiliation: Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría, CMN Siglo-XXI, Instituto Mexicano del Seguro Social (IMSS), Avenida Cuauhtémoc 330, Colonia Doctores, Delegación Cuauhtémoc, 06720 Ciudad de México, DF, Mexico.
authors.forename: María G
authors.initials: MG
authors.lastname: Cárdenas-Mondragón
authors.affiliation: Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría, CMN Siglo-XXI, Instituto Mexicano del Seguro Social (IMSS), Avenida Cuauhtémoc 330, Colonia Doctores, Delegación Cuauhtémoc, 06720 Ciudad de México, DF, Mexico.
authors.forename: Javier
authors.initials: J
authors.lastname: Torres
authors.affiliation: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Avenida Universidad 655, Colonia Santa María Ahuacatitlán, 62100 Cuernavaca, MOR, Mexico.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Flores-Luna
authors.affiliation: Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría, CMN Siglo-XXI, Instituto Mexicano del Seguro Social (IMSS), Avenida Cuauhtémoc 330, Colonia Doctores, Delegación Cuauhtémoc, 06720 Ciudad de México, DF, Mexico.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Carreón-Talavera
authors.affiliation: Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría, CMN Siglo-XXI, Instituto Mexicano del Seguro Social (IMSS), Avenida Cuauhtémoc 330, Colonia Doctores, Delegación Cuauhtémoc, 06720 Ciudad de México, DF, Mexico.
authors.forename: Margarita
authors.initials: M
authors.lastname: Camorlinga-Ponce
authors.affiliation: Unidad de Investigación en Virología y Cáncer, Hospital Infantil de México Federico Gómez, Dr. Márquez 162, Colonia Doctores, Delegación Cuauhtémoc, 06720 Ciudad de México, DF, Mexico.
authors.forename: Ezequiel M
authors.initials: EM
authors.lastname: Fuentes-Pananá
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D004381:Duodenal Ulcer / Q000150:complications / Q000382:microbiology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D016481:Helicobacter Infections / Q000150:complications; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010437:Peptic Ulcer / Q000150:complications* / Q000382:microbiology / Q000821:virology*; D012307:Risk Factors; D013276:Stomach Ulcer / Q000150:complications / Q000382:microbiology / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G