title: [Value of serum beta-human chorionic gonadotropin on day 9 and 11 after embryo transfer in predicting pregnancy outcomes].
abstract: OBJECTIVE
  To investigate the value of serum beta-human chorionic gonadotropin (β-HCG) on days 9 (d9) and 11 (d11) after fresh embryo transfer (ET) and frozen-thawed embryo transfer (FET) in predicting the pregnancy outcomes.
  
  
  METHODS
  A total of 227 fresh ET and FET cycles performed at the Center of Reproductive Medicine, Qingyuan People's Hospital between Dec, 2012 and Feb, 2014 were analyzed. The data of serum β-HCG levels on d9 and d11 after fresh ET and FET cycles and the pregnancy outcomes were reviewed, and the ROC curve was constructed to determine the optimal cut-off level of serum β-HCG level for predicting pregnancy outcomes.
  
  
  RESULTS
  According to pregnancy outcomes, the cycles were divided into non-pregnancy group (group A), biochemical pregnancy group (group B), and clinical pregnancy group (group C). Significant differences were found between the mean serum β-HCG levels measured on d9 and d11 in all the 3 groups (P<0.01). The cycles in group C were further divided into 5 subgroups with single pregnancy (C1), twin pregnancy (C2), early abortion (C3), ectopic pregnancy (C4), or intrauterine pregnancy complicated with ectopic pregnancy group (C5), and all the 5 subgroups showed significant differences in β-HCG measurements between d9 and d11 (P<0.01). On d9 after ET and FET, the optimal cut-off level of serum β-HCG was 49.05 IU/L for predicting for clinical pregnancy, and was 105.15 IU/L for predicting twin pregnancy; the two corresponding cut-off levels of serum β-HCG on d11 was 51.2 IU/L and 241.75 IU/L, respectively.
  
  
  CONCLUSIONS
  The absolute serum β-HCG level on d9 and d11 after fresh ET and FET allows an accurate diagnosis of pregnancy and helps in the prediction of the pregnancy outcomes.
authors.affiliation: Center of Reproductive Medicine,Department of Gynecology & Obstetrics,Nanfang Hospital, Southern Medical University,Guangzhou 510515,China.E-mail: cairong1222@163.com.
authors.forename: Cairong
authors.initials: C
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Quan
authors.forename: Qiuxiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Li
authors.forename: Peichang
authors.initials: P
authors.lastname: Qiu
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhao
authors.forename: Linrong
authors.initials: L
authors.lastname: Zhou
authors.forename: Haiyan
authors.initials: H
authors.lastname: Guo
mesh_terms: D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human