title: Hypereosinophilic obliterative bronchiolitis with an elevated level of serum CEA: a case report and a review of the literature.
abstract: A 44-year-old man presented with chronic, persistent cough and occasional wheezing. Airflow obstruction, blood eosinophilia and a remarkable elevated level of serum carcinoembryonic antigen (CEA) were found. Radiographic and pathological studies confirmed eosinophilic bronchiolitis. There was no evidence of neoplasms by extensive examinations. After a protracted oral steroid therapy, the blood eosinophil count, the serum CEA level and the lung lesions were all improved in parallel, whereas fixed airflow obstruction remained. This case was diagnosed as a new distinct syndrome, hypereosinophilic obliterative bronchiolits. Serum CEA and blood eosinophil cell count served as good markers of the disease condition for this syndrome.
authors.affiliation: Department of Respiratory Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. shanpingjiang@126.com.
authors.forename: T-T
authors.initials: TT
authors.lastname: Tang
authors.forename: H-H
authors.initials: HH
authors.lastname: Cheng
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: X-L
authors.initials: XL
authors.lastname: Lin
authors.forename: L-J
authors.initials: LJ
authors.lastname: Huang
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: S-P
authors.initials: SP
authors.lastname: Jiang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001989:Bronchiolitis Obliterans / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D003371:Cough / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D008297:Male
chemical_list: D015415:Biomarkers; D002272:Carcinoembryonic Antigen