title: Association of serum hepatocyte growth factor with pericardial fat volume in patients with coronary artery disease.
abstract: Hepatocyte growth factor (HGF), as a metabolic regulator, was shown to be secreted by adipose tissue and associated with metabolic syndrome (MS) and coronary artery disease (CAD). Pericardial fat, as a visceral fat, was found to be a significant predictor of CAD. We investigated the relationship between serum HGF levels and pericardial fat volume (PFV) in individuals aged between 40-65 years without liver or renal diseases, and also without medicine consumption. Serum HGF levels were found to be significantly higher in participants with CAD than those without CAD (P<0.001). In addition, the serum HGF levels had a significant positive correlation with the PFV in all the participants (r=0.485, P<0.001). Multivariate linear regression demonstrated that the serum HGF levels were significantly associated with PFV (β value=0.454, P<0.001) after adjustment for the metabolic parameters. Further regression assessment found that the serum HGF levels were significantly associated with PFV in participants with CAD (β value=0.586, P<0.001). The serum HGF levels were significant and independent predictors for determining the presence of CAD (OR=1.002, 95% CI: 1.000-1.004, P=0.011). This study therefore demonstrated that the serum HGF levels positively correlated with PFV in participants with CAD and can therefore be a significant predictor for the presence of CAD.
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University Jiangsu, China.
authors.forename: Jingning
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University Jiangsu, China.
authors.forename: Zhengxia
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University Jiangsu, China.
authors.forename: Shikun
authors.initials: S
authors.lastname: Cai
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University Jiangsu, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University Jiangsu, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Nanjing Medical University Jiangsu, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Peng
keywords: Hepatocyte growth factor; coronary artery disease; metabolic syndrome; pericardial fat volume