title: Ion channel therapeutics for pain.
abstract: Pain is a complex disease which can progress into a debilitating condition. The effective treatment of pain remains a challenge as current therapies often lack the desired level of efficacy or tolerability. One therapeutic avenue, the modulation of ion channel signaling by small molecules, has shown the ability to treat pain. However, of the 215 ion channels that exist in the human genome, with 85 ion channels having a strong literature link to pain, only a small number of these channels have been successfully drugged for pain. The focus of future research will be to fully explore the possibilities surrounding these unexplored ion channels. Toward this end, a greater understanding of ion channel modulation will be the greatest tool we have in developing the next generation of drugs for the treatment of pain.
authors.affiliation: a Worldwide Medicinal Chemistry; Pfizer Global R&D ; Cambridge , UK.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Skerratt
authors.affiliation: b Worldwide Medicinal Chemistry; Pfizer Global R&D ; Durham , NC USA.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: West
mesh_terms: D000777:Anesthetics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D059225:Nociception / Q000187:drug effects; D010146:Pain / Q000188:drug therapy*; D026941:Sodium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D061566:Voltage-Gated Sodium Channels / Q000378:metabolism*
chemical_list: D000777:Anesthetics; D026941:Sodium Channel Blockers; D061566:Voltage-Gated Sodium Channels
keywords: clinical compounds; drug discovery; ion channels; pain; sodium channels