title: The influence of enriched environment on spatial memory in Swiss mice of different ages.
abstract: The objective of this study was to evaluate the influence of enriched environment on spatial memory acquisition in mice of three different age groups. Weanling, young, and young adult female Swiss mice were housed in a standard control or enriched environment for 50 days, and their spatial memory was tested with the Morris Water Maze. We did not observe an experimental effect for spatial memory acquisition, and there was neither an effect of time of analysis nor an interaction between experimental group and time of analysis. Regarding effects of experimental group and training day in relation to latency in finding the hidden platform, we did find an effect in the experimental young adult mice group (p = 0.027), but there was no interaction between these factors in all three groups. Based on these findings environmental enrichment did not enhance spatial memory acquisition in female Swiss mice in the tested age groups.
authors.affiliation: Universidade Federal de Mato Grosso do Sul, Campo Grand, MS, Brazil.
authors.forename: Alessandra Fernandes
authors.initials: AF
authors.lastname: Druzian
authors.affiliation: Universidade Federal de Mato Grosso do Sul, Campo Grand, MS, Brazil.
authors.forename: José Aparecido de Oliveira
authors.initials: JA
authors.lastname: Melo
authors.affiliation: Faculdade de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Albert Schiaveto de
authors.initials: AS
authors.lastname: Souza
mesh_terms: D000367:Age Factors; D000818:Animals; D004780:Environment, Controlled; D005260:Female; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D023421:Models, Animal; D011897:Random Allocation; D012016:Reference Values; D065852:Spatial Memory / Q000502:physiology*; D013647:Task Performance and Analysis; D013997:Time Factors