title: A Tutorial on Target-Mediated Drug Disposition (TMDD) Models.
abstract: Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials.
authors.affiliation: Pharmatherapeutics Research Clinical Pharmacology, Pfizer Neusentis Cambridge, UK.
authors.forename: P
authors.initials: P
authors.lastname: Dua
authors.affiliation: Pharmatherapeutics Research Clinical Pharmacology, Pfizer Neusentis Cambridge, UK ; Department of Mathematics, University of Surrey Guildford, UK.
authors.forename: E
authors.initials: E
authors.lastname: Hawkins
authors.affiliation: Leiden Academic Centre for Drug Research (LACDR), Systems Pharmacology Leiden, The Netherlands.
authors.forename: P H
authors.initials: PH
authors.lastname: van der Graaf