title: Management of Low-Stage Testicular Seminoma.
abstract: Management of testicular seminoma has benefited from numerous advances in imaging, radiotherapy, and chemotherapy over the last 50 years leading to nearly 100% disease-specific survival for low-stage seminoma. This article examines the evaluation and management of low-stage testicular seminoma, which includes clinical stage I and IIA disease. Excellent outcomes for stage I seminoma are achieved with active surveillance, adjuvant radiotherapy, and adjuvant single-agent carboplatin. Current areas of research focus on optimizing surveillance regimens and minimizing the morbidity and long-term complications of adjuvant treatment. Radiotherapy continues to be the primary treatment option for patients with clinical stage IIa disease.
authors.affiliation: Section of Urology, Department of Surgery, University of Chicago, 5841 South Maryland Avenue, MC 6038, Chicago, IL 60637, USA. Electronic address: pearce.shane@gmail.com.
authors.forename: Shane M
authors.initials: SM
authors.lastname: Pearce
authors.affiliation: Department of Radiation and Cellular Oncology, University of Chicago, 5841 South Maryland Avenue, MC 6038, Chicago, IL 60637, USA.
authors.forename: Stanley L
authors.initials: SL
authors.lastname: Liauw
authors.affiliation: Section of Urology, Department of Surgery, University of Chicago, 5841 South Maryland Avenue, MC 6038, Chicago, IL 60637, USA.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Eggener
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D003131:Combined Modality Therapy; D019468:Disease Management; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009919:Orchiectomy / Q000379:methods*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D012307:Risk Factors; D018239:Seminoma / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013736:Testicular Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin
keywords: Chemotherapy; Radiotherapy; Seminoma; Stage I; Stage II; Surveillance