title: Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker.
abstract: By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small-molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjusted. Following cell uptake of 60 nm aggregates, the aggregates are stable and nontoxic to macrophage cells up to 55 × 10(-3) m Au.
authors.affiliation: Department of Molecular Medicine, Beckman Research Institute, City of Hope, 1500 East Duarte Rd, Duarte, CA, 91010, USA.|Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA.
authors.forename: Desiree
authors.initials: D
authors.lastname: Van Haute
authors.affiliation: Department of Molecular Medicine, Beckman Research Institute, City of Hope, 1500 East Duarte Rd, Duarte, CA, 91010, USA.
authors.forename: Julia M
authors.initials: JM
authors.lastname: Longmate
authors.affiliation: Department of Molecular Medicine, Beckman Research Institute, City of Hope, 1500 East Duarte Rd, Duarte, CA, 91010, USA.|Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA.
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Berlin
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008823:Micelles; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D008823:Micelles; D013438:Sulfhydryl Compounds; D014867:Water; D006046:Gold
keywords: biocompatible materials; covalent assembly; gold nanoparticles; nanoaggregates; nanoclusters