title: Study of enrichment factors for six β-blockers in aliphatic alcohols by hollow-fiber liquid-phase microextraction.
abstract: The selectivity of a suitable organic solvent is key for extraction in liquid-phase microextraction experiments. Nevertheless, the screening process remains a daunting task. Our research aimed to study the relationship between extraction efficiency and extraction solvents, analytes, and finally select the appropriate extraction solvent. In the present article, β-blockers and six extraction solvents were chosen as the models and hollow-fiber liquid-phase microextraction was conducted. The relationship was built by statistical analysis on the data. Factors affecting extraction efficiency including the logarithms of the octanol/water partition coefficient (logPo/w ) of analytes, acid dissociation constants, the logarithms of the octanol/water partition coefficient of solvents and pH of the sample solution were investigated. The results showed that a low water solubility of extraction solvent is the foundation to ensure higher extraction efficiency. Moreover, when ΔlogPo/w > 0, a higher extraction efficiency is observed at lower ΔlogPo/w , on the contrary, when ΔlogPo/w < 0, extraction efficiency is higher as the absolute value of ΔlogPo/w becomes greater. Finally, the relationship between enrichment factor and extraction solvents, analytes was established and a helpful guidance was provided for the selection of an optimal solvent to obtain the best extraction efficiency by liquid-phase microextraction.
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China.
authors.forename: Qing-Lian
authors.initials: QL
authors.lastname: Li
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China.
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Jing
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Zhang
authors.affiliation: Institute of Forensic Science of Supreme People's Procuratorate, Beijing, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Ran
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China.
authors.forename: Chao-Hui
authors.initials: CH
authors.lastname: Du
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D005233:Fatty Alcohols; D006801:Humans; D006863:Hydrogen-Ion Concentration; D059627:Liquid Phase Microextraction / Q000379:methods*; D008956:Models, Chemical; D012997:Solvents
chemical_list: D000319:Adrenergic beta-Antagonists; D005233:Fatty Alcohols; D012997:Solvents
keywords: Analytes; Extraction efficiency; Extraction solvent; Liquid-phase microextraction