title: Effects of real and simulated weightlessness on the cardiac and peripheral vascular functions of humans: A review.
abstract: Weightlessness is an extreme environment that can cause a series of adaptive changes in the human body. Findings from real and simulated weightlessness indicate altered cardiovascular functions, such as reduction in left ventricular (LV) mass, cardiac arrhythmia, reduced vascular tone and so on. These alterations induced by weightlessness are detrimental to the health, safety and working performance of the astronauts, therefore it is important to study the effects of weightlessness on the cardiovascular functions of humans. The cardiovascular functional alterations caused by weightlessness (including long-term spaceflight and simulated weightlessness) are briefly reviewed in terms of the cardiac and peripheral vascular functions. The alterations include: changes of shape and mass of the heart; cardiac function alterations; the cardiac arrhythmia; lower body vascular regulation and upper body vascular regulation. A series of conclusions are reported, some of which are analyzed, and a few potential directions are presented.
authors.affiliation: Central South University, Changsha, Hunan, China (School of Energy Science and Engineering). zhuhui@csu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Hunan University of Technology, Zhuzhou, Hunan, China (Collaborative Innovation Center for Energy-conservation in Buildings and Environment Control). hqwang2011@126.com.
authors.forename: Hanqing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Central South University, Changsha, Hunan, China (School of Energy Science and Engineering). liuzq@csu.edu.cn.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002319:Cardiovascular System / Q000503:physiopathology*; D006801:Humans; D013026:Space Flight; D018474:Weightlessness Simulation
keywords: cardiac functions; peripheral vascular functions; weightlessness