title: Autoimmune disorders in patients with T-cell lymphoma: a comprehensive review.
abstract: BACKGROUND
  Increased risk of B-cell lymphoma in patients with autoimmune diseases is well known. Medical literature also links various autoimmune conditions with T-cell lymphomas (TCLs), a rarer but very heterogeneous group of generally aggressive neoplasms.
  
  
  METHODS
  Herein, we provide a comprehensive analysis of the available peer-reviewed literature on epidemiology, clinico-laboratory features and management of autoimmune diseases in patients with TCL. Most relevant publications were identified through searching the PubMed/Medline database for articles published from inception to June 2014.
  
  
  RESULTS
  Prevalence of various hematologic and non-hematologic autoimmune conditions in patients with TCL appears to be increased. Due to the rarity of TCL, scientific literature on autoimmune conditions in these patients consists mainly of case series and isolated reports.
  
  
  CONCLUSIONS
  Autoimmune disorders can develop prior to, during or after the onset of TCL. The diagnosis of TCL should prompt early recognition of certain autoimmune disorders if clinical suspicion exists. A dysfunctional immune response in these patients may be responsible for the occurrence of autoimmunity. Conversely, autoimmune conditions might create a favorable milieu for T-cell lymphoma pathogenesis. Therefore, their presence should increase the suspicion of TCL in an appropriate clinico-laboratory context. There is need for larger studies to assess further the TCL-autoimmunity relationship as prognosis and management of these patients can be considerably affected.
authors.affiliation: a a University of Connecticut , Internal Medicine, Farmington, CT , USA.
authors.forename: Magali
authors.initials: M
authors.lastname: Van den Bergh
authors.affiliation: a a University of Connecticut , Internal Medicine, Farmington, CT , USA.
authors.forename: Juliana
authors.initials: J
authors.lastname: Alvarez-Argote
authors.affiliation: a a University of Connecticut , Internal Medicine, Farmington, CT , USA.
authors.forename: Amruta H
authors.initials: AH
authors.lastname: Panwala
authors.affiliation: b b Lucy Curci Cancer Center, Eisenhower Medical Center, Rancho Mirage , CA , USA.
authors.forename: Constantin A
authors.initials: CA
authors.lastname: Dasanu
mesh_terms: D015551:Autoimmunity / Q000276:immunology*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000276:immunology*; D015995:Prevalence; D011379:Prognosis
keywords: Autoimmune disorders; Epidemiology; Non-Hodgkin lymphoma; T-cell lymphoma