title: [Measurement of natriuretic peptides in heart failure: the good laboratory and clinical practice].
abstract: Cardiac natriuretic peptides (BNP, NT-proBNP) play a pivotal role in cardiovascular homeostasis, mainly due to their roles in vasodilatation, natriuresis, diuresis and due to their antiproliferative properties. Proper measurement of the natriuretic peptide levels may help differentiate between respiratory and cardiac forms of dyspnea, diagnose early forms of heart failure, evaluate severity of heart failure (prognosis) and monitor the efficacy of therapy. In many countries natriuretic peptide levels are being used as one of the earliest diagnostics tools to evaluate the involvement of the heart. Current theoretical and clinical data confirm the importance of natriuretic peptides in routine healthcare. These roles are clearly described in international recommendations and guidelines. In the current review the authors discuss the problems of the measurement of natriuretic peptides in Hungary, including several aspects related to laboratory medicine, cardiology and health economy.
authors.affiliation: Laboratóriumi Medicina Intézet, Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Pécs, Ifjúság útja 20., 7624.
authors.forename: L Gábor
authors.initials: LG
authors.lastname: Kovács
authors.forename: Noémi
authors.initials: N
authors.lastname: Nyolczas
authors.forename: Tamás
authors.initials: T
authors.lastname: Habon
authors.forename: Róbert
authors.initials: R
authors.lastname: Sepp
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Piroth
authors.forename: Ágota
authors.initials: Á
authors.lastname: Hajas
authors.forename: Imre
authors.initials: I
authors.lastname: Boncz
authors.forename: János
authors.initials: J
authors.lastname: Tomcsányi
authors.forename: János
authors.initials: J
authors.lastname: Kappelmayer
authors.forename: Béla
authors.initials: B
authors.lastname: Merkely
mesh_terms: D000208:Acute Disease; D000553:Ambulatory Care / Q000379:methods / Q000592:standards; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000191:economics / Q000379:methods / Q000592:standards; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004180:Direct Service Costs; D004417:Dyspnea / Q000209:etiology*; D006333:Heart Failure / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000191:economics; D006801:Humans; D006814:Hungary; D020097:Natriuretic Peptide, Brain / Q000097:blood; D045265:Natriuretic Peptides / Q000097:blood*; D010343:Patient Admission; D010351:Patient Discharge; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D011933:Reagent Kits, Diagnostic / Q000592:standards; D012140:Respiratory Tract Diseases / Q000175:diagnosis; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D045265:Natriuretic Peptides; D010446:Peptide Fragments; D011933:Reagent Kits, Diagnostic; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: BNP; NT-proBNP; diagnosis; diagnózis; dyspnea; heart failure; nehézlégzés; szívelégtelenség