title: Danger signals in stroke.
abstract: Danger molecules are the first signals released from dying tissue after stroke. These danger signals bind to receptors on immune cells that will result in their activation and the release of inflammatory and neurotoxic mediators, resulting in amplification of the immune response and subsequent enlargement of the damaged brain volume. The release of danger signals is a central event that leads to a multitude of signals and cascades in the affected and neighbouring tissue, therefore providing a potential target for therapy.
authors.affiliation: Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. Electronic address: m.gelderblom@uke.de.
authors.forename: Mathias
authors.initials: M
authors.lastname: Gelderblom
authors.affiliation: Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Clayton, Victoria, Australia; Department of Surgery, Monash Medical Centre, Southern Clinical School, Monash University, Clayton, Victoria, Australia.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Sobey
authors.affiliation: Department of Neurology, University Clinics Wuerzburg, Josef-Schneider-Straße 11, 97080 Wuerzburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Kleinschnitz
authors.affiliation: Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. Electronic address: t.magnus@uke.de.
authors.forename: Tim
authors.initials: T
authors.lastname: Magnus
mesh_terms: D000818:Animals; D006801:Humans; D020521:Stroke / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*
keywords: DAMP; HMGB1; Hsp; Inflammation; Stroke