title: Temporal changes in calcium-binding proteins in the medial geniculate nucleus of the monkey Sapajus apella.
abstract: The subdivisions of the medial geniculate complex can be distinguished based on the immunostaining of calcium-binding proteins and by the properties of the neurons within each subdivision. The possibility of changes in neurochemistry in this and other central auditory areas are important aspects to understand the basis that contributing to functional variations determined by environmental cycles or the animal's cycles of activity and rest. This study investigated, for the first time, day/night differences in the amounts of parvalbumin-, calretinin- and calbindin-containing neurons in the thalamic auditory center of a non-human primate, Sapajus apella. The immunoreactivity of the PV-IR, CB-IR and CR-IR neurons demonstrated different distribution patterns among the subdivisions of the medial geniculate. Moreover, a high number of CB- and CR-IR neurons were found during day, whereas PV-IR was predominant at night. We conclude that in addition to the chemical heterogeneity of the medial geniculate nucleus with respect to the expression of calcium-binding proteins, expression also varied relative to periods of light and darkness, which may be important for a possible functional adaptation of central auditory areas to environmental changes and thus ensure the survival and development of several related functions.
authors.affiliation: Department of Speech-Language and Hearing Therapy, São Paulo State University, Marilia, SP, Brazil; University of Marilia, Medical School, Marilia, SP, Brazil.
authors.forename: Leila M G
authors.initials: LM
authors.lastname: Campos
authors.affiliation: Department of Speech-Language and Hearing Therapy, São Paulo State University, Marilia, SP, Brazil.
authors.forename: Elaine C
authors.initials: EC
authors.lastname: Osório
authors.affiliation: Department of Speech-Language and Hearing Therapy, São Paulo State University, Marilia, SP, Brazil.
authors.forename: Graziela Ligia da Silva
authors.initials: GL
authors.lastname: Santos
authors.affiliation: Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil.
authors.forename: Maria Inês
authors.initials: MI
authors.lastname: Nogueira
authors.affiliation: Department of Basic sciences, São Paulo State University, Araçatuba, SP, Brazil.
authors.forename: Roelf J
authors.initials: RJ
authors.lastname: Cruz-Rizzolo
authors.affiliation: Department of Speech-Language and Hearing Therapy, São Paulo State University, Marilia, SP, Brazil. Electronic address: lpinato@marilia.unesp.br.
authors.forename: Luciana
authors.initials: L
authors.lastname: Pinato
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000166:cytology / Q000378:metabolism; D064032:Calbindin 2 / Q000378:metabolism; D064026:Calbindins / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002428:Cebus; D002940:Circadian Rhythm; D005829:Geniculate Bodies / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000378:metabolism; D010320:Parvalbumins / Q000378:metabolism; D013788:Thalamus / Q000378:metabolism
chemical_list: D064032:Calbindin 2; D064026:Calbindins; D002135:Calcium-Binding Proteins; D010320:Parvalbumins
keywords: Auditory system; Biological rhythm; Calcium-binding proteins; Primate