title: Comparison of dynamic contrast-enhanced magnetic resonance imaging with T2-weighted imaging for preoperative staging of early endometrial carcinoma.
abstract: OBJECTIVE
  This study aimed to compare dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with T2-weighted imaging (T2WI) for the preoperative staging of early endometrial carcinoma.
  
  
  METHODS
  This retrospective study included 22 subjects with early endometrial carcinoma who underwent 3.0 T MRI examination prior to hysterectomy. DCE-MRI and T2WI were evaluated for the preoperative staging of endometrial carcinoma. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of DCE-MRI and T2WI were assessed and compared using the revised International Federation of Gynecology and Obstetrics surgical staging guidelines (2009) as the reference standard.
  
  
  RESULTS
  Out of the 22 cases of endometrial carcinoma, the use of the reference standard method led to the staging of 14 as IA and eight as IB. The sensitivity, specificity, PPV, NPV, and accuracy of DCE-MRI for preoperative staging were 100% (95% confidence interval: 0.73-1.0), 62.5% (95% CI: 0.26-0.90), 82.4% (95% CI: 0.56-0.95), 100% (95% CI: 0.46-1.0), and 86.4%, respectively, and these values were 85.7% (95% CI: 0.56-0.97), 75% (95% CI: 0.36-0.96), 85.7% (95% CI: 0.56-0.97), 75% (95% CI: 0.36-0.96), and 81.8%, respectively, for T2WI. Thus, the sensitivity and accuracy of DCE-MRI were greater than those of T2WI for preoperative endometrial carcinoma staging.
  
  
  CONCLUSIONS
  DCE-MRI was more sensitive but less specific than T2WI for the preoperative staging of early endometrial carcinoma. DCE-MRI may serve as a useful and reliable tool for the preoperative assessment of endometrial carcinoma.
authors.affiliation: Department of Radiology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China ; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Linfeng
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Obstetrics and Gynecology, Dengfeng People's Hospital, Zhengzhou, People's Republic of China.
authors.forename: Sujuan
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Radiology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Xifu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Zhuoli
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Guixiang
authors.initials: G
authors.lastname: Zhang
keywords: T2-weighted imaging; dynamic contrast-enhanced magnetic resonance imaging; endometrial carcinoma; preoperative staging