title: Associations Between Inflammatory Markers, Hemostatic Markers, and Microvascular Complications in 182 Chinese Patients With Type 2 Diabetes Mellitus.
abstract: OBJECTIVE
  To examine the associations between inflammatory markers, coagulation and fibrinolysis parameters, and microvascular complications in 182 Chinese patients with type 2 diabetes mellitus (T2DM) who sought treatment at a large hospital in Zhejiang province, China.
  
  
  METHODS
  We investigated the relationships of blood inflammatory markers with hemostatic markers in 87 patients with T2DM who did not have complications and 95 patients with T2DM who had microvascular complications.
  
  
  RESULTS
  C-reactive protein (CRP) and interleukin-6 (IL-6) were significantly correlated with fibrinogen, thrombin-antithrombin III complex (TAT III), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF), and coagulation factors (F) VII in patients with T2DM who had microvascular complications (P <.05). Based on logistic regression analysis, the highest-tertile groups of fibrinogen, FVII, and FVIII, corresponded to a greater risk of high CRP, whereas risk of high IL-6 was significantly greater in the groups with highest-tertile values for fibrinogen, FVII, TAT III, PAI-1, and activated protein C (APC).
  
  
  CONCLUSIONS
  Elevated levels of CRP and IL-6 might be associated with increased coagulability and a tendency towards thrombus formation in patients with T2DM who have microvascular complications.
authors.affiliation: Department of Gynecology and Obstetrics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
authors.forename: Nengneng
authors.initials: N
authors.lastname: Zheng
authors.affiliation: Clinical Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
authors.forename: Xinping
authors.initials: X
authors.lastname: Shi
authors.affiliation: Endocrinology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Gynecology and Obstetrics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China wenlv_td@126.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Lv
mesh_terms: D000328:Adult; D000368:Aged; D000990:Antithrombin III; D044466:Asian People; D002097:C-Reactive Protein / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004730:Endothelium, Vascular / Q000473:pathology*; D005167:Factor VII; D005260:Female; D005340:Fibrinogen; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D014841:von Willebrand Factor
chemical_list: D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D000990:Antithrombin III; D005167:Factor VII; D005340:Fibrinogen; D002097:C-Reactive Protein
keywords: C-reactive protein; hemostatic marker; interleukin-6; microvascular complication; type 2 diabetes mellitus