title: Gray-scale and color Doppler sonographic features of complex fibroadenomas of the breast.
abstract: OBJECTIVE
  To investigate gray-scale and color Doppler sonographic (US) features of complex fibroadenoma (FA), according to the Breast Imaging-Reporting and Data System (BI-RADS) lexicon.
  
  
  METHODS
  From 2010 through 2013, 586 women with FAs were seen; 101 (17%) of those lesions were diagnosed as complex FAs on percutaneous needle biopsy or surgery. Among the patients with complex FAs, 67 who had US examination results available were included in this study. In addition, the results from 98 women who had simple FAs were included as controls. US features were retrospectively analyzed by two breast radiologists in consensus for shape, margin, echogenicity, posterior acoustic pattern, boundary, orientation, and associated findings. They also reassessed the BI-RADS category for FAs. Color Doppler US examination results were classified according to the amount of vascularity as absent, moderate, or marked.
  
  
  RESULTS
  Complex FA were larger than simple FAs were (14.5 cm versus 12.1 cm, p > 0.05). On univariate analysis, a round to irregular shape, an uncircumscribed margin, the presence of associated findings, and BI-RADS categorization as 4a and 4b were more frequently revealed in complex than in simple FAs (p < 0.05). Multivariate analysis revealed that the tumor margin was a predictive factor for complex FA (odds ratio: 6.08; 95% confidence interval: 1.14-32.49, p < 0.05). On color Doppler US, the complex FAs had higher degrees of vascularity than simple FA (p < 0.05).
  
  
  CONCLUSIONS
  Complex FAs, in comparison with simple FAs, tend to have more aggressive features and to be in higher BI-RADS categories on US examination.
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Kwang Hwi
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Suk Jung
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Park
authors.affiliation: Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Woogyeong
authors.initials: W
authors.lastname: Kim
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Jong Woon
authors.initials: JW
authors.lastname: Song
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Yun-Jung
authors.initials: YJ
authors.lastname: Lim
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Baek
authors.affiliation: Department of Radiology, Myongji Hospital, Hwasu-ro 14, Deogyang-gu, Goyang-si, Gyeonggi-do, 412-270, Republic of Korea.
authors.forename: Seon-Jeong
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
authors.forename: Yedaun
authors.initials: Y
authors.lastname: Lee
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018615:Ultrasonography, Doppler, Color; D016217:Ultrasonography, Mammary / Q000379:methods*; D055815:Young Adult
keywords: BI-RADS; breast; color Doppler ultrasonography; complex fibroadenoma