title: Efficacy, safety, and outcomes in 17 pediatric cases treated with the free radical scavenger edaravone.
abstract: METHODS
  Edaravone is a free radical scavenger with brain protection properties and is recommended by "The Japanese Guidelines for the Management of Stroke 2009" for administration to adult patients, in whom it has been shown to improve neurological deficits after cerebral infarction. However, its dosage and effects have not yet been established in children.
  
  
  METHODS
  Seventeen pediatric patients with cerebral ischemia were administered edaravone at a dose based on body weight from the standard dose given to adults. Functional outcomes were evaluated using mRS and PSOM (modified ranking scale and pediatric stroke outcome scale, respectively).
  
  
  RESULTS
  Immediate post-treatment results were mostly positive, with no liver or renal complications. In some cases, neurological symptoms markedly improved after the administration of edaravone.
  
  
  CONCLUSIONS
  The efficacy of edaravone has not yet been examined in pediatric patients. The results of the present study suggest that edaravone has potential in the treatment of children safely with promising results similar to those in adults.
authors.affiliation: Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Nakamoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Aihara
authors.forename: Koji
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Takakazu
authors.initials: T
authors.lastname: Kawamata
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000293:Adolescent; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D000077553:Edaravone; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009072:Moyamoya Disease / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine