title: Papillon-Lefèvre syndrome: clinical presentation and management options.
abstract: Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder, characterized by diffuse palmoplantar keratoderma and precocious aggressive periodontitis, leading to premature loss of deciduous and permanent dentition at a very young age. Various etiopathogenic factors are associated with the syndrome, like immunologic alterations, genetic mutations, and the role of bacteria. Dentists play a significant role in the diagnosis and management of PLS as there are characteristic manifestations like periodontal destruction at an early age and an early eruption of permanent teeth. Here, we are presenting an elaborate review of PLS, its etiopathogenesis, clinical presentation, and management options.
authors.affiliation: Department of Prosthodontics, Government Dental College and Hospital, Hyderabad, Telangana State, India.
authors.forename: Basapogu
authors.initials: B
authors.lastname: Sreeramulu
authors.affiliation: Department of Oral Pathology, Government Dental College and Hospital, Hyderabad, Telangana State, India.
authors.forename: Naragani Dvn
authors.initials: ND
authors.lastname: Shyam
authors.affiliation: Department of Prosthodontics, Government Dental College and Hospital, Hyderabad, Telangana State, India.
authors.forename: Pilla
authors.initials: P
authors.lastname: Ajay
authors.affiliation: Department of Prosthodontics, Government Dental College and Hospital, Hyderabad, Telangana State, India.
authors.forename: Pathipaka
authors.initials: P
authors.lastname: Suman
keywords: deciduous and permanent dentition; modified complete dentures; palmoplantar keratoderma; periodontitis