title: A BODIPY-based 'turn-on' fluorescent probe for hypoxic cell imaging.
abstract: A boron-dipyrromethene (BODIPY) dye containing a styryl substituent with a hydroxyl and nitro group, 1a, exhibits a 'turn-on' fluorescence response for hypoxic cells. The presence of the electron-withdrawing nitro group results in a highly efficient nonradiative decay of the S1 state, and hence a recovery of fluorescence intensity when nitro reduction occurs under hypoxic conditions.
authors.affiliation: Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, P. R. China. hualu@hznu.edu.cn.
authors.forename: Sisi
authors.initials: S
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: John
authors.initials: J
authors.lastname: Mack
authors.forename: Jiangwei
authors.initials: J
authors.lastname: Tian
authors.forename: Bin
authors.initials: B
authors.lastname: Zou
authors.forename: Hua
authors.initials: H
authors.lastname: Lu
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Li
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Jiang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Shen
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004583:Electrons; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D008968:Molecular Conformation; D011789:Quantum Theory
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes