title: First Reported Case of Unexpected Response to an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in the I744M Uncommon EGFR Mutation.
authors.affiliation: Gustave Roussy Cancer Campus, Drug Development Department and University Paris-Sud, Villejuif, France. Electronic address: emma@kempf.pro.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Kempf
authors.affiliation: Gustave Roussy Cancer Campus, Department of Medical Biology and Pathology, Translational Research Laboratory and Biobank (UMS3655 CNRS /US23 INSERM), INSERM Unit U981, Villejuif, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Lacroix
authors.affiliation: Gustave Roussy Cancer Campus, Drug Development Department and University Paris-Sud, Villejuif, France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Soria
mesh_terms: D000368:Aged; D054316:Biomarkers, Pharmacological / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D004252:DNA Mutational Analysis; D003967:Diarrhea / Q000209:etiology; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics; D011237:Predictive Value of Tests; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D011799:Quinazolines / Q000008:administration & dosage* / Q000009:adverse effects; D012135:Respiratory Sounds / Q000187:drug effects* / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D054316:Biomarkers, Pharmacological; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; C512478:EGFR protein, human; D066246:ErbB Receptors; D000077156:Gefitinib
keywords: Gefitinib; I744M mutation; Non–small-cell lung cancer; Oncogene addiction; Rare EGFR mutation