title: [MicroRNAs in kidney fibrosis].
abstract: Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function with accumulation of extracellular matrix components in the renal parenchyma. The molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the profibrotic role of several microRNAs (miRNAs) has been described in kidney fibrosis. MiRNAs are a new class of, small non-coding RNAs of about 20 nucleotides that act as gene expression negative regulators at the post-transcriptional level. Seminal studies have highlighted the potential importance of miRNA as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review summarizes recent scientific advances on the role played by miRNAs in kidney fibrogenesis and discusses potential clinical applications as well as future research directions.
authors.affiliation: EA4483, pôle recherche, faculté de médecine de Lille, université de Lille, 1, place de Verdun, 59045 Lille cedex, France.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Van der Hauwaert
authors.affiliation: EA4483, pôle recherche, faculté de médecine de Lille, université de Lille, 1, place de Verdun, 59045 Lille cedex, France.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Savary
authors.affiliation: EA4483, pôle recherche, faculté de médecine de Lille, université de Lille, 1, place de Verdun, 59045 Lille cedex, France.
authors.forename: Marie-Flore
authors.initials: MF
authors.lastname: Hennino
authors.affiliation: EA4483, pôle recherche, faculté de médecine de Lille, université de Lille, 1, place de Verdun, 59045 Lille cedex, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pottier
authors.affiliation: EA4483, pôle recherche, faculté de médecine de Lille, université de Lille, 1, place de Verdun, 59045 Lille cedex, France; Service de néphrologie, hôpital Huriez, CHRU de Lille, boulevard Michel-Polonovski, 59037 Lille cedex, France. Electronic address: francois.glowacki@chru-lille.fr.
authors.forename: François
authors.initials: F
authors.lastname: Glowacki
authors.affiliation: EA4483, pôle recherche, faculté de médecine de Lille, université de Lille, 1, place de Verdun, 59045 Lille cedex, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Cauffiez
mesh_terms: D015415:Biomarkers; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology*; D035683:MicroRNAs / Q000502:physiology*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Biomarkers; Biomarqueur; Fibrose rénale; MicroARN; MicroRNA; Renal fibrosis