title: Eosinophilia in Rheumatologic/Vascular Disorders.
abstract: Peripheral and tissue eosinophilia can be a prominent feature of several unique rheumatologic and vascular diseases. These diseases span a wide range of clinical features, histologic findings, therapeutic approaches, and outcomes. Despite the rare nature of these entities--which makes large-scale studies challenging--knowledge has continued to grow regarding their epidemiology, pathophysiology, and management. This review compares and contrasts 5 rheumatologic and vascular conditions in which eosinophilia can be seen: eosinophilic granulomatosis with polyangiitis (Churg-Strauss), immunoglobulin G4-related disease, diffuse fasciitis with eosinophilia, eosinophilia-myalgia syndrome, and eosinophilic myositis.
authors.affiliation: Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, A50, Cleveland, OH 44195, USA.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tamaki
authors.affiliation: Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, A50, Cleveland, OH 44195, USA.
authors.forename: Soumya
authors.initials: S
authors.lastname: Chatterjee
authors.affiliation: Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, 9500 Euclid Avenue, A50, Cleveland, OH 44195, USA. Electronic address: langfoc@ccf.org.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Langford
mesh_terms: D001172:Arthritis, Rheumatoid / Q000473:pathology; D015267:Churg-Strauss Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D004802:Eosinophilia / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D016603:Eosinophilia-Myalgia Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D004804:Eosinophils / Q000473:pathology*; D005208:Fasciitis / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D049288:Muscular Dystrophies, Limb-Girdle / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D014364:Tryptophan / Q000378:metabolism
chemical_list: D014364:Tryptophan
keywords: Diffuse fasciitis with eosinophilia; Eosinophilia-myalgia syndrome; Eosinophilic fasciitis; Eosinophilic granulomatosis with polyangiitis (Churg-Strauss); Eosinophilic myositis; Immunoglobulin G4-related disease