title: Synthesis and Reactivity Profile of Ylidenemalononitrile Enamines and Their Ester Analogs Towards Electrophiles and Nucleophiles.
abstract: Herein, we describe the synthesis and reactivity of enamines derived from ylidenemalononitriles and ylidenecyanoacetates. The enamine scope was expanded by (1) increasing yields of aldehyde-derived ylidenemalononitriles, (2) incorporating silyl functionalities, and (3) using other amide acetals to expand the substitution patterns of pyridines resulting from enamine cyclization. In addition, methods to produce α-pyrones and polysubstituted pyridines from both ylidenemalononitriles and ylidenecyanoacetates are described.
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University , 95 Chieftan Way, Tallahassee, Florida 32306, United States.
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Longstreet
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University , 95 Chieftan Way, Tallahassee, Florida 32306, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rivalti
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University , 95 Chieftan Way, Tallahassee, Florida 32306, United States.
authors.forename: D Tyler
authors.initials: DT
authors.lastname: McQuade