title: Near infrared light-actuated gold nanorods with cisplatin-polypeptide wrapping for targeted therapy of triple negative breast cancer.
abstract: Despite considerable progress being made in breast cancer therapy, the complete eradication of highly aggressive triple negative breast cancer (TNBC) remains a notable challenge today. We herein report on the fabrication of novel gold nanorods (GNRs) with covalent cisplatin-polypeptide wrapping and folic acid (FA) conjugation (FA-GNR@Pt) for the targeted photothermal (PT) therapy and chemotherapy of TNBC. The FA-GNR@Pt hybrid nanoparticles are designed to integrate the photothermal conversion property of GNRs, the superior biocompatibility of polypeptide poly(l-glutamic acid) (PGA), the chemotoxicity of cisplatin, and the tumor targeting ability of FA into one single nanoplatform. In combination with localized near infrared (NIR) laser illumination, the resulting FA-GNR@Pt hybrid nanoparticles are able to significantly inhibit the growth of the TNBC tumor when administered systemically. In particular, they can extensively suppress the dissemination of TNBC cells from the primary tumor to the lung by eliminating the peripheral tumor blood vessels. Collectively, our studies demonstrate that the combined PT therapy and chemotherapy using cisplatin-loaded GNRs with FA conjugation might imply a promising strategy for targeted treatment of TNBC.
authors.affiliation: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. hjyu@simm.ac.cn ypli@simm.ac.cn.
authors.forename: Bing
authors.initials: B
authors.lastname: Feng
authors.forename: Zhiai
authors.initials: Z
authors.lastname: Xu
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Zhou
authors.forename: Haijun
authors.initials: H
authors.lastname: Yu
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Sun
authors.forename: Dangge
authors.initials: D
authors.lastname: Wang
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Tang
authors.forename: Haiyang
authors.initials: H
authors.lastname: Yu
authors.forename: Qi
authors.initials: Q
authors.lastname: Yin
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000628:therapy*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007259:Infrared Rays; D008297:Male; D051379:Mice; D008819:Mice, Nude; D043942:Nanotubes / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000737:chemistry / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
chemical_list: D011099:Polyglutamic Acid; D006046:Gold; D002945:Cisplatin