title: Analysis of survival data in thalassemia patients in Shiraz, Iran.
abstract: OBJECTIVE
  The survival rate of thalassemia patients has not been conclusively established, and the factors associated with survival remain unclear. This study aimed to determine the survival rate of thalassemia among patients in southern Iran and to identify the factors associated with mortality from thalassemia.
  
  
  METHODS
  This retrospective cohort study was conducted based on a retrospective review of the medical records of 911 beta-thalassemia patients in 2014. Data analysis was conducted using the Kaplan-Meier method and Cox regression analysis.
  
  
  RESULTS
  Overall, 212 patients (23.3%) died, and 26.8% had thalassemia intermedia. The 20-year, 40-year, and 60-year survival rates were 85%, 63%, and 54%, respectively. Both crude and adjusted analyses found that education, marital status, ferritin levels, and comorbidities were related to mortality.
  
  
  CONCLUSIONS
  Sociodemographic and hematological factors were found to be significantly associated with the survival rate of thalassemia. Addressing these factors may help healthcare providers and physicians to provide the best possible care and to improve the survival rate.
authors.affiliation: Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Rajaeefard
authors.affiliation: Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Hajipour
authors.affiliation: Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Tabatabaee
authors.affiliation: Department of Epidemiology, Research Centre for Health Sciences, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Hassanzadeh
authors.affiliation: Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Shahab
authors.initials: S
authors.lastname: Rezaeian
authors.affiliation: Department of Midwifery, School of Nursing and Midwifery, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Moradi
authors.affiliation: Center for Disease Control and Prevention, Deputy of Health Services, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sharafi
authors.affiliation: Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Shafiee
authors.affiliation: Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Semati
authors.affiliation: Islamic Azad University Khorasgan (Isfahan) Branch, Isfahan, Iran.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Safaei
authors.affiliation: Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Soltani
keywords: Iran; Kaplan-Meier estimate; Survival; Thalassemia