title: The use of posaconazole against Chagas disease.
abstract: OBJECTIVE
  The current therapeutic scenario against Chagas disease has been recently updated with the use of the triazoles in clinical trials and several experimental assays (in-vitro and in-vivo models) which are bringing novel and promising evidence for the treatment of Chagas diseases, mainly in its chronic phase. We pretend to analyze all the evidence extracted from the in-vitro and in-vivo assays, and try to understand the poor outcome of posaconazole (POS) in the clinical experience.
  
  
  RESULTS
  POS is the drug with more advanced development in both experimental model and clinical trial. Despite the promising results initially obtained in the animal model, the clinical trial did not meet expectations. Nevertheless, it has documented the activity against Trypanosoma cruzi either in the animal model or in humans. Also new treatment strategies, combination or sequential schemes, have been evaluated in the animal model.
  
  
  CONCLUSIONS
  POS has been tested in humans showing activity against T. cruzi, but not enough to reach cure by itself. Those results represent one of the most important breakthroughs in the treatment of Chagas disease, and open a window to new strategies as combination therapies or even sequential treatments.
authors.affiliation: Department of Infectious Disease, Vall d'Hebron Teaching Hospital, International Health Program of the Catalan Institute of Health (PROSICS) Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Israel
authors.initials: I
authors.lastname: Molina
authors.forename: Fernando
authors.initials: F
authors.lastname: Salvador
authors.forename: Adrián
authors.initials: A
authors.lastname: Sánchez-Montalvá
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D014230:Triazoles; D014344:Trypanocidal Agents; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D014230:Triazoles; D014344:Trypanocidal Agents; C101425:posaconazole