title: Efficacy of weekly docetaxel in locally advanced cardiac angiosarcoma.
abstract: BACKGROUND
  Primary cardiac angiosarcoma is extremely aggressive; however, it is often misdiagnosed because of its rarity. For locally advanced tumors, doxorubicin-based chemotherapy regimens are the standard of treatment, even if the gain in term of progression-free survival is limited and is no longer than 5 months.
  
  
  METHODS
  We report the case of a Caucasian 23-year-old man with locally advanced cardiac angiosarcoma who underwent radical surgical resection after a prolonged response to weekly docetaxel and complementary radiotherapy.
  
  
  CONCLUSIONS
  Combined treatment with weekly docetaxel and radiotherapy may be a valid alternative for the treatment of locally advanced cardiac angiosarcoma; the combination can lead to radical surgical resections, avoiding the cumulative cardiotoxicity of antracycline-based regimens.
authors.affiliation: Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. med.minichillo@hotmail.it.
authors.forename: Santino
authors.initials: S
authors.lastname: Minichillo
authors.affiliation: Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. maria.pantaleo@unibo.it.|"Giorgio Prodi" Cancer Research Center, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. maria.pantaleo@unibo.it.
authors.forename: Maria Abbondanza
authors.initials: MA
authors.lastname: Pantaleo
authors.affiliation: Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. margherita.nannini@unibo.it.|"Giorgio Prodi" Cancer Research Center, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. margherita.nannini@unibo.it.
authors.forename: Margherita
authors.initials: M
authors.lastname: Nannini
authors.affiliation: Cardiovascular Department of the University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. fabio.coccolo@aosp.bo.it.
authors.forename: Fabio
authors.initials: F
authors.lastname: Coccolo
authors.affiliation: Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. lidia.gatto83@gmail.com.
authors.forename: Lidia
authors.initials: L
authors.lastname: Gatto
authors.affiliation: Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. guido.biasco@unibo.it.|"Giorgio Prodi" Cancer Research Center, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. guido.biasco@unibo.it.
authors.forename: Guido
authors.initials: G
authors.lastname: Biasco
authors.affiliation: Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. giovanni.brandi@unibo.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Brandi
mesh_terms: D003131:Combined Modality Therapy / Q000379:methods*; D000077143:Docetaxel; D017809:Fatal Outcome; D005720:Gamma Rays / Q000627:therapeutic use*; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D043823:Taxoids / Q000627:therapeutic use*; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D043823:Taxoids; D000077143:Docetaxel