title: Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy.
abstract: In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.
authors.affiliation: Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.|Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, CA, 94305-5484, USA.
authors.forename: Ruiping
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China.
authors.forename: Quli
authors.initials: Q
authors.lastname: Fan
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, CA, 94305-5484, USA.|Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, CA, 94305-5484, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Cheng
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Lu
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, CA, 94305-5484, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004738:Engineering; D056945:Hep G2 Cells; D006801:Humans; D008543:Melanins / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles; D009536:Niacinamide / Q000031:analogs & derivatives / Q000737:chemistry; D010671:Phenylurea Compounds / Q000737:chemistry; D061088:Photoacoustic Techniques / Q000379:methods*; D049268:Positron-Emission Tomography; D012995:Solubility; D000077157:Sorafenib; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008543:Melanins; D010671:Phenylurea Compounds; D014867:Water; D009536:Niacinamide; D000077157:Sorafenib
keywords: drug delivery; melanin nanoparticles; photoacoustic imaging; positron emission tomography (PET); sorafenib