title: Differentiation of Donor-Derived Cells Into Microglia After Umbilical Cord Blood Stem Cell Transplantation.
abstract: Recent studies have indicated that microglia originate from immature progenitors in the yolk sac. After birth, microglial populations are maintained under normal conditions via self-renewal without the need to recruit monocyte-derived microglial precursors. Peripheral cell invasion of the brain parenchyma can only occur with disruption of the blood-brain barrier. Here, we report an autopsy case of an umbilical cord blood transplant recipient in whom cells derived from the donor blood differentiated into ramified microglia in the recipient brain parenchyma. Although the blood-brain barrier and glia limitans seemed to prevent invasion of these donor-derived cells, most of the invading donor-derived ramified cells were maintained in the cerebral cortex. This result suggests that invasion of donor-derived cells occurs through the pial membrane.
authors.affiliation: From the Department of Neurology, National Hospital Organization Iou Hospital (KT); Departments of Neurology and Neurobiology of Aging (KT, YK, IN, MY) and Cellular Transplantation Biology (SM, HY), Kanazawa University Graduate School of Medical Science; and Department of Internal Medicine, Keijyu Kanazawa Hospital (SM), Kanazawa, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kakuda
authors.forename: Saori
authors.initials: S
authors.lastname: Munemoto
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nozaki
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D001921:Brain / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D036101:Cord Blood Stem Cell Transplantation / Q000639:trends*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D017628:Microglia / Q000502:physiology*; D008875:Middle Aged