title: Acute Disseminated Encephalomyelitis in a Child Following Plasmodium vivax Malaria.
abstract: Acute Disseminated Encephalomyelitis (ADEM) is a multifocal, monophasic, acute demyelinating disease of the brain and spinal cord, which is commonly preceded by viral infections and occasionally bacterial infections or immunizations. Its occurrence following malarial infection, especially Plasmodium vivax Malaria is very uncommon. We report an 11-year girl who presented with clinical features of encephalopathy and generalized convulsions, 10 days following complete recovery from the Plasmodium vivax Malaria. Diagnosis of ADEM as a complication of Plasmodium vivax Malaria was made based on acute onset of neurological events, characteristic findings on Magnetic Resonance Imaging (MRI) of brain and prompt response to corticosteroid therapy. Follow-up MRI, 6 months after discharge, showed complete resolution of change found on the initial MRI. To the best of our knowledge, only two such cases have been reported in the English literature till date.
authors.affiliation: Department of Paediatric Medicine1/ Radiology2, NRS Medical College and Hospital, 138, AJC Bose Road, Kolkata-700014, West Bengal, India.
authors.forename: Radheshyam
authors.initials: R
authors.lastname: Purkait
authors.affiliation: Department of Paediatric Medicine, NRS Medical College and Hospital, 138, AJC Bose Road, Kolkata-700014, West Bengal, India.
authors.forename: Aritra
authors.initials: A
authors.lastname: Mukherji
authors.affiliation: Department of Paediatric Medicine, NRS Medical College and Hospital, 138, AJC Bose Road, Kolkata-700014, West Bengal, India.
authors.forename: Tapankumar
authors.initials: T
authors.lastname: Sinhamahapatra
authors.affiliation: Department of Radiology, NRS Medical College and Hospital, 138, AJC Bose Road, Kolkata-700014, West Bengal, India.
authors.forename: Ramchandra
authors.initials: R
authors.lastname: Bhadra
mesh_terms: D002648:Child; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D016780:Malaria, Vivax / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D010966:Plasmodium vivax / Q000302:isolation & purification; D011239:Prednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone