title: [Diversity-oriented synthesis and its application in drug discovery].
abstract: Diversity-oriented synthesis (DOS) aims to efficiently generate collections of small molecules with diverse appendages, functional groups, stereochemistry and skeletons, thus yielding diverse biological activities capable of modulating a wide variety of biological processes. In this review, we discussed the common strategies employed in DOS with specific examples from recent literature, including reagent-based approach, substrate-based approach, build-couple-pair strategy and privileged substructure-based DOS. The application of some DOS libraries in drug discovery is also presented.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Ming-yue
authors.initials: MY
authors.lastname: Zheng
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D015195:Drug Design; D055808:Drug Discovery; D054852:Small Molecule Libraries
chemical_list: D054852:Small Molecule Libraries