title: Cortical folding and the potential for prognostic neuroimaging in schizophrenia.
abstract: In 41 patients with schizophrenia, we used neuroanatomical information derived from structural imaging to identify patients with more severe illness, characterised by high symptom burden, low processing speed, high degree of illness persistence and lower social and occupational functional capacity. Cortical folding, but not thickness or volume, showed a high discriminatory ability in correctly identifying patients with more severe illness.
authors.affiliation: Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
authors.forename: Shuixia
authors.initials: S
authors.lastname: Guo
authors.affiliation: Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
authors.forename: Sarina
authors.initials: S
authors.lastname: Iwabuchi
authors.affiliation: Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
authors.forename: Vijender
authors.initials: V
authors.lastname: Balain
authors.affiliation: Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Feng
authors.affiliation: Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Liddle
authors.affiliation: Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada Lena.Palaniyappan@nottingham.ac.uk.
authors.forename: Lena
authors.initials: L
authors.lastname: Palaniyappan
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D006113:United Kingdom; D055815:Young Adult