title: Plasma BDNF levels associate with Pittsburgh compound B binding in the brain.
abstract: BACKGROUND
  Brain-derived neurotrophic factor (BDNF) plays an important role in Alzheimer's disease (AD) and other neurodegenerative disorders. BDNF function is adversely affected by amyloid beta (Aβ) in AD. BDNF levels in brain and peripheral tissues are lower in patients with AD and MCI, than in controls. Here we examined the association between plasma levels of BDNF and amyloid deposition in the brain measured with Pittsburgh Compound B (PiB).
  
  
  METHODS
  Our dataset consisted of 18 AD, 56 mild cognitive impairment (MCI) and 3 normal control (NC) Alzheimer's Disease Neuroimaging Initiative-1 (ADNI1) subjects with available [11C] PiB and peripheral blood protein data. MRI-coregistered PET data was smoothed with a 15 mm kernel and mapped onto 3D hemispheric models using the warping deformations computed in cortical pattern matching of the associated MRI scans. We applied linear regression to examine in 3D the associations between BDNF and PiB SUVR, while adjusting for age and sex. We used permutation statistics thresholded at p<0.01 for multiple comparisons correction.
  
  
  RESULTS
  Plasma BDNF levels showed significant negative associations with left greater than right amyloid burden in the lateral temporal, inferior parietal, inferior frontal, anterior and posterior cingulate, and orbitofrontal regions (left pcorrected=0.03).
  
  
  CONCLUSIONS
  As hypothesized, lower plasma levels of BDNF were significantly associated with widespread brain amyloidosis.
authors.affiliation: Oakland University William Beaumont School of Medicine, Rochester Hills, MI USA.
authors.forename: Kristy S
authors.initials: KS
authors.lastname: Hwang
authors.affiliation: University of California Berkeley, Berkeley, CA, USA.
authors.forename: Andreas S
authors.initials: AS
authors.lastname: Lazaris
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Eastman
authors.affiliation: Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA ; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Edmond
authors.initials: E
authors.lastname: Teng
authors.affiliation: Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, CA, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.affiliation: School of Nursing, UCLA, CA, USA.
authors.forename: Karen H
authors.initials: KH
authors.lastname: Gylys
authors.affiliation: Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA ; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Cole
authors.affiliation: Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA ; Mary S. Easton Center for Alzheimer's Disease Research, UCLA, Los Angeles, CA, USA.
authors.forename: Liana G
authors.initials: LG
authors.lastname: Apostolova