title: A retrospective analysis of complications observed in children with acute lymphoblastic leukemia during chemotherapy.
abstract: BACKGROUND
  We aimed to evaluate the complications that we observed in children with acute lymphoblastic leukemia (ALL) during the remission induction, consolidation, and reinduction phases of chemotherapy retrospectively.
  
  
  METHODS
  We analysed the clinical records of 128 patients with ALL who were diagnosed and treated in the Department of Pediatric Hematology of Istanbul Medeniyet University Goztepe Training Hospital between August 2009 and April 2014 to document the acute complication other than febrile neutropenia episodes, which developed during the induction, consolidation and reinduction phases of chemotherapy.
  
  
  RESULTS
  We documented 279 complications. Of these, 53.05% were in males, 46.95% in females; 32.26% were in standard-risk, 45.52% in medium-risk, 22.22% in high-risk group of patients. Common documented events were pneumonia (25%), therapy-induced hyperglycemia (16.40%) therapy-related hepatitis (15.6%), generalized tonic-clonic seizures (14.8%), anaphylaxis to asparaginase (14.1%), hypertension (13.3%) varicella zoster virus (VZV) infection (13.3%), renal tubulopathy (12.5%). Time of complications was induction phase in 32.62%, consolidation in 19.35%, HR blocks in 18.28%, reinduction 29.75% during the phases. Mortality rate due to complications was 13.28%.
  
  
  CONCLUSIONS
  Therapy-related complications can limit the survival rates in children with ALL. To minimize the treatment burden, even very rare complications must be considered and treated promptly with a multidisciplinary approach.
authors.affiliation: Pediatric Hematology Department, Goztepe Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey - canbolataylin@hotmail.com.
authors.forename: Aylin
authors.initials: A
authors.lastname: Canbolat Ayhan
authors.affiliation: Pediatric Hematology Department, Goztepe Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Timur
authors.affiliation: Pediatric Hematology Department, Goztepe Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Kalaycik
mesh_terms: D000293:Adolescent; D000707:Anaphylaxis / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012074:Remission Induction / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014421:Turkey
chemical_list: D000970:Antineoplastic Agents; D001215:Asparaginase