title: Dependence of tablet brittleness on tensile strength and porosity.
abstract: An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet brittleness and tensile strength. These equations have the potential to facilitate better characterization of tablet mechanical properties and to guide the design and optimization of pharmaceutical tablet products.
authors.affiliation: Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Xingchu
authors.initials: X
authors.lastname: Gong
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Shao-Yu
authors.initials: SY
authors.lastname: Chang
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Frederick
authors.initials: F
authors.lastname: Osei-Yeboah
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Shubhajit
authors.initials: S
authors.lastname: Paul
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Sathyanarayana Reddy
authors.initials: SR
authors.lastname: Perumalla
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Limin
authors.initials: L
authors.lastname: Shi
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA. Electronic address: sunx0053@umn.edu.
authors.forename: Wei-Jhe
authors.initials: WJ
authors.lastname: Sun
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Changquan Calvin
authors.initials: CC
authors.lastname: Sun
mesh_terms: D017311:Amlodipine / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005905:Glyburide / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry; D016062:Porosity; D011208:Powders; D027561:Salvia miltiorrhiza; D000068677:Sildenafil Citrate / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*; D013718:Tensile Strength; D013806:Theophylline / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; C519374:Panax notoginseng extract; D011208:Powders; D013229:Stearic Acids; D013607:Tablets; C028972:dan-shen root extract; D017311:Amlodipine; C031183:stearic acid; D012822:Silicon Dioxide; D002482:Cellulose; D000068677:Sildenafil Citrate; D013806:Theophylline; D005905:Glyburide; D007052:Ibuprofen
keywords: Brittleness; Porosity; Tablet; Tensile strength