title: Developmental and behavioral consequences of prenatal methamphetamine exposure: A review of the Infant Development, Environment, and Lifestyle (IDEAL) study.
abstract: This study reviews the findings from the Infant Development, Environment, and Lifestyle (IDEAL) study, a multisite, longitudinal, prospective study designed to determine maternal outcome and child growth and developmental findings following prenatal methamphetamine exposure from birth up to age 7.5 years. These findings are presented in the context of the home environment and caregiver characteristics to determine how the drug and the environment interact to affect the outcome of these children. No neonatal abstinence syndrome requiring pharmacologic intervention was observed but heavy drug exposure was associated with increased stress responses in the neonatal period. Poorer inhibitory control was also observed in heavy methamphetamine exposed children placing them at high risk for impaired executive function. Independent of methamphetamine exposure, children with more responsive home environments to developmental and emotional needs demonstrated lower risks for internalizing and externalizing behavior.
authors.affiliation: Department of Pediatrics, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: smith@labiomed.org.
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Smith
authors.affiliation: Department of Pediatrics, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Diaz
authors.affiliation: Pediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA.
authors.forename: Linda L
authors.initials: LL
authors.lastname: LaGasse
authors.affiliation: Department of Psychological Medicine, University of Auckland, New Zealand.
authors.forename: Trecia
authors.initials: T
authors.lastname: Wouldes
authors.affiliation: Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Derauf
authors.affiliation: Department of Psychology, The University of Tulsa, Tulsa, OK, USA.
authors.forename: Elana
authors.initials: E
authors.lastname: Newman
authors.affiliation: Family Science Department, Center on Young Adult Health and Development, University of Maryland School of Public Health, College Park, MD, USA.
authors.forename: Amelia
authors.initials: A
authors.lastname: Arria
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
authors.forename: Marilyn A
authors.initials: MA
authors.lastname: Huestis
authors.affiliation: Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: William
authors.initials: W
authors.lastname: Haning
authors.affiliation: Miller Children's Hospital Long Beach (MCHLB), Long Beach, CA, USA.
authors.forename: Arthur
authors.initials: A
authors.lastname: Strauss
authors.affiliation: Pediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA.
authors.forename: Sheri
authors.initials: S
authors.lastname: Della Grotta
authors.affiliation: Pediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA.
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Dansereau
authors.affiliation: Department of Psychological Medicine, University of Auckland, New Zealand.
authors.forename: Charles
authors.initials: C
authors.lastname: Neal
authors.affiliation: Pediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA.
authors.forename: Barry M
authors.initials: BM
authors.lastname: Lester
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D002658:Developmental Disabilities / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007223:Infant; D008019:Life Style; D008694:Methamphetamine / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000503:physiopathology / Q000523:psychology
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine
keywords: Longitudinal; Methamphetamine; Neurodevelopment; Prenatal exposure