title: Invasion phenotypes of oral squamous cell carcinoma.
abstract: The invasion signature of tumor cells can strongly affect their metastatic behavior; therefore, we aimed to evaluate the different invasion phenotypes of oral squamous cell carcinoma (OSCC) and to determine the correlation of these markers with neoplastic mode of invasion. A total of 92 OSCCs were graded according to the Yamamoto criteria and subjected to immunohistochemistry using monoclonal antibodies against E-cadherin, N-cadherin, and podoplanin. Samples were grouped into epithelial-mesenchymal transition (EMT), collective-cell invasion (CCI), and combined intermediate phenotypes followed by statistical analysis. Significant differences were found among the 3 groups (P<0.001), between EMT and CCI (P=0.023) and between the combined phenotypes and both EMT and CCI, separately (P<0.001). Mode of invasion was significantly associated with E-cadherin (P=0.022), but not the other markers. There seems to be a preference for OSCCs to migrate by CCI; however, most our samples showed an intermediate phenotype between EMT and CCI, which confirm the existence of a spectrum of migration signatures that need to be further evaluated in these tumors.
authors.affiliation: Dental Research Centre, Dental Research Institute, Dental Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shahroo
authors.initials: S
authors.lastname: Etemad-Moghadam
authors.forename: Mojgan
authors.initials: M
authors.lastname: Alaeddini
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000276:immunology; D009062:Mouth Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D000098853:Podoplanin
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin