title: Aerosol-based detectors for liquid chromatography.
abstract: Aerosol-based detectors developed within the last few decades have increasingly addressed the need for sensitive, universal liquid chromatography detection in a wide variety of applications. Herein, we review the operating principles, instrumentation, analytical characteristics, and recent applications of the three general types of such detectors: evaporative light scattering detection (ELSD), condensation nucleation light scattering detection (CNLSD); commercially known as the nano-quantity analyte detector (NQAD), and charged aerosol detection (CAD). Included is a comparative evaluation of the operational and analytical characteristics of these detectors.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
authors.forename: Lars-Erik
authors.initials: LE
authors.lastname: Magnusson
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
authors.forename: Donald S
authors.initials: DS
authors.lastname: Risley
authors.affiliation: Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL, United States. Electronic address: koropcha@siu.edu.
authors.forename: John A
authors.initials: JA
authors.lastname: Koropchak
mesh_terms: D000336:Aerosols; D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods; D008027:Light; D012542:Scattering, Radiation
chemical_list: D000336:Aerosols
keywords: Aerosol-based detectors; Liquid chromatography detectors; Universal detectors