title: IL-10-592 A/C polymorphisms is associated with EBV-HLH in Chinese children.
abstract: OBJECTIVE
  The aim of this study is to investigate the relationship between cytokine gene polymorphisms and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in children, and to further reveal the possible mechanisms of EBV-HLH.
  
  
  METHODS
  Forty-one patients with EBV-HLH, 70 patients with infectious mononucleosis (IM), and 170 EBV-seropositive healthy children were evaluated. Gene polymorphism typing was performed by a polymerase chain reaction with a sequence-specific primer of a commercially available cytokine genotyping kit. Comparison of cytokine gene polymorphisms between EBV-HLH, IM patients, and healthy controls was analyzed statistically using Chi-square test or Fisher's exact test.
  
  
  RESULTS
  The frequencies of IL-10-592 C allele or IL-10-592 CC genotype were significantly higher in patients with EBV-HLH than in IM and healthy children (P < 0.001), but no significant difference was observed between IM and healthy children.
  
  
  CONCLUSIONS
  IL-10-592 locus gene polymorphism is associated with the development of EBV-HLH in Chinese children.
authors.affiliation: a Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University , China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University , China.
authors.forename: Junhong
authors.initials: J
authors.lastname: Ai
authors.affiliation: a Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University , China.
authors.forename: Zhengde
authors.initials: Z
authors.lastname: Xie
authors.affiliation: b Department of Infection , Beijing Children's Hospital, Capital Medical University , China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Qin
authors.affiliation: a Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University , China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wu
authors.affiliation: a Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University , China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University , China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Liu
authors.affiliation: b Department of Infection , Beijing Children's Hospital, Capital Medical University , China.
authors.forename: Kunling
authors.initials: K
authors.lastname: Shen
mesh_terms: D000293:Adolescent; D000483:Alleles; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D002681:China; D020031:Epstein-Barr Virus Infections / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D004854:Herpesvirus 4, Human; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: Children; Cytokine; Epstein–Barr virus; Genotype; Haplotype; Hemophagocytic lymphohistiocytosis; Interlukin; Polymorphisms