title: Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.
abstract: The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Guo
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Liu
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Changlong
authors.initials: C
authors.lastname: Yu
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Shibi
authors.initials: S
authors.lastname: Lu
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Jingxiang
authors.initials: J
authors.lastname: Huang
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Peng
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Aiyuan
authors.initials: A
authors.lastname: Wang
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Chen
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Sui
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Xu
authors.affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Quanyi
authors.initials: Q
authors.lastname: Guo