title: Rh-catalyzed sequential oxidative C-H activation/annulation with geminal-substituted vinyl acetates to access isoquinolines.
abstract: The concise synthesis of 3-substituted or non-C3-substituted isoquinolines through Rh-catalyzed sequential oxidative C-H activation/annulation with geminal-substituted vinyl acetates was developed with good functional group tolerance. The protocol was successfully applied to the total synthesis of the natural product papaverine.
authors.affiliation: School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou, 213164, P. R. China. yujintao@cczu.edu.cn jiangcheng@cczu.edu.cn.
authors.forename: Haoke
authors.initials: H
authors.lastname: Chu
authors.forename: Song
authors.initials: S
authors.lastname: Sun
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Yu
authors.forename: Jiang
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000085:Acetates / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010091:Oximes / Q000737:chemistry; D010208:Papaverine / Q000138:chemical synthesis*; D012238:Rhodium; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000085:Acetates; D010091:Oximes; D014753:Vinyl Compounds; D010208:Papaverine; D012238:Rhodium