title: Escaping Negative Selection: ILC You in the Gut.
abstract: How commensal-specific T cells are controlled in the periphery is poorly understood. In a recent issue of Science, Hepworth et al. (2015) show that ILC3s induce apoptosis of microbiota-specific CD4 T cells in a form of extrathymic negative selection.
authors.affiliation: Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Farkas
authors.affiliation: Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: ii2137@cumc.columbia.edu.
authors.forename: Ivaylo I
authors.initials: II
authors.lastname: Ivanov
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003106:Colon / Q000382:microbiology*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000382:microbiology*; D008297:Male
chemical_list: D000949:Histocompatibility Antigens Class II