title: R5 Macrophage-Tropic HIV-1 in the Male Genital Tract.
abstract: The entry tropism of HIV-1 Env proteins from virus isolated from the blood and genital tract of five men with compartmentalized lineages was determined. The Env proteins isolated from the genital tract of subject C018 were macrophage-tropic proteins, while the remaining cloned env genes encoded R5 T cell-tropic proteins. The detection of a macrophage-tropic lineage of HIV-1 within the male genital tract strongly suggests that evolution of macrophage-tropic viruses can occur in anatomically isolated sites outside the central nervous system.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Bednar
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Blake M
authors.initials: BM
authors.lastname: Hauser
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Ping
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Dukhovlinova
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Shuntai
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Kathryn T
authors.initials: KT
authors.lastname: Arrildt
authors.affiliation: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Irving F
authors.initials: IF
authors.lastname: Hoffman
authors.affiliation: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Eron
authors.affiliation: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Myron S
authors.initials: MS
authors.lastname: Cohen
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA risunc@med.unc.edu.
authors.forename: Ronald
authors.initials: R
authors.lastname: Swanstrom
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D015870:Gene Expression; D005837:Genitalia, Male / Q000821:virology*; D005838:Genotype; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000821:virology*; D008297:Male; D058889:Molecular Typing; D010802:Phylogeny; D012661:Semen / Q000821:virology; D019562:Viral Load; D056189:Viral Tropism / Q000235:genetics*; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics* / Q000378:metabolism
chemical_list: D054299:env Gene Products, Human Immunodeficiency Virus