title: Dirchromones: Cytotoxic Organic Sulfur Compounds Isolated from Dirca palustris.
abstract: Eight novel organic sulfur compounds featuring an unprecedented structure among natural organosulfur molecules are reported. The identified compounds, named dirchromones (1-8), were isolated from a dichloromethane extract of the roots, bark, and wood of Dirca palustris, an endemic shrub of eastern North America. Their identification was based on thorough NMR, IR, and HRMS spectroscopic data interpretation. These compounds showed cytotoxic and mild Gram-positive antibacterial activities in vitro, while being inactive against Gram-negative Escherichia coli and the yeast Candida albicans. This is the first report of sulfur-containing compounds from a species of the Thymelaeaceae.
authors.affiliation: Chaire de Recherche sur les Agents Anticancéreux d'Origine Naturelle, Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi , 555 Boulevard de l'Université, Chicoutimi, Québec, Canada , G7H 2B1.
authors.forename: Alexis
authors.initials: A
authors.lastname: St-Gelais
authors.affiliation: Chaire de Recherche sur les Agents Anticancéreux d'Origine Naturelle, Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi , 555 Boulevard de l'Université, Chicoutimi, Québec, Canada , G7H 2B1.
authors.forename: Jean
authors.initials: J
authors.lastname: Legault
authors.affiliation: Chaire de Recherche sur les Agents Anticancéreux d'Origine Naturelle, Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi , 555 Boulevard de l'Université, Chicoutimi, Québec, Canada , G7H 2B1.
authors.forename: Vakhtang
authors.initials: V
authors.lastname: Mshvildadze
authors.affiliation: Chaire de Recherche sur les Agents Anticancéreux d'Origine Naturelle, Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi , 555 Boulevard de l'Université, Chicoutimi, Québec, Canada , G7H 2B1.
authors.forename: André
authors.initials: A
authors.lastname: Pichette
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002170:Canada; D002176:Candida albicans / Q000187:drug effects; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009930:Organic Chemicals; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D013457:Sulfur Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029645:Thymelaeaceae / Q000737:chemistry*; D014934:Wood / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002867:Chromones; D009930:Organic Chemicals; D010936:Plant Extracts; D013457:Sulfur Compounds