title: Can Exercise Ameliorate Aromatase Inhibitor-Induced Cognitive Decline in Breast Cancer Patients?
abstract: Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor-positive breast cancer. Due to the nature of aromatase, the key enzyme for endogenous estrogen synthesis, inhibitory of aromatase-induced side effects, such as cognitive impairment has been reported in both human and animal studies. While extensive evidence suggested that physical exercises can improve learning and memory activity and even prevent age-related cognitive decline, basic research revealed some common pathways between exercise and estrogen signaling that affected cognitive function. This review draws on clinical and basic studies to assess the potential impact of exercise in cognitive function from women treated with AIs for breast cancer and explore the potential mechanism and effects of exercise on estrogen-related cognition.
authors.affiliation: Department of Sport Psychology, School of Sport Science, Shanghai University of Sport, Shanghai, 200438, China.
authors.forename: Cuicui
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Sport Psychology, School of Sport Science, Shanghai University of Sport, Shanghai, 200438, China. Chenglin_600@126.com.
authors.forename: Chenglin
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Sport Psychology, School of Sport Science, Shanghai University of Sport, Shanghai, 200438, China. rli@rfdn.org.|Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital and Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100012, China. rli@rfdn.org.|Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL, 34243, USA. rli@rfdn.org.
authors.forename: Rena
authors.initials: R
authors.lastname: Li
mesh_terms: D000818:Animals; D047072:Aromatase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D060825:Cognitive Dysfunction / Q000139:chemically induced*; D004195:Disease Models, Animal; D004967:Estrogens / Q000378:metabolism; D015444:Exercise; D005260:Female; D006801:Humans
chemical_list: D047072:Aromatase Inhibitors; D004967:Estrogens
keywords: Aromatase inhibitors; Breast cancer; Cognition; Exercise