title: A Challenging Case of Primary Breast Hodgkin's Lymphoma.
abstract: Primary breast lymphoma (PBL) is a rare entity accounting for less than 1% of all breast malignancies. Diagnostic criteria for primary Hodgkin's lymphoma of the breast are: the presence of sufficient tissue for diagnosis, close interaction between mammary tissue and lymphomatous infiltrate and no evidence or prior diagnosis of widespread lymphoma. Our case illustrates an unusual presentation of Hodgkin's lymphoma of the breast: clinically as inflammatory breast cancer and core biopsy as granulomatous mastitis, the final diagnosis requiring surgical biopsy. Current information regarding this entity is scant, mainly build upon its rarity. In this paper we assess the clinical presentation, the step-by-step diagnosis, the treatment and the importance of immunohistochemistry in this uncommon condition.
authors.affiliation: Department of Surgery, Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Narcis Octavian
authors.initials: NO
authors.lastname: Zarnescu
authors.affiliation: Department of Pathology, Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Andreea
authors.initials: A
authors.lastname: Iliesiu
authors.affiliation: Department of Pathology, Emergency University Hospital, Bucharest, Romania.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Procop
authors.affiliation: Department of Dermatology II, "Colentina" Clinical Hospital, Bucharest, Romania.
authors.forename: Mircea
authors.initials: M
authors.lastname: Tampa
authors.affiliation: Department of Dermatology II, "Colentina" Clinical Hospital, Bucharest, Romania.
authors.forename: Clara
authors.initials: C
authors.lastname: Matei
authors.affiliation: Department of Pathology, Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Maria
authors.initials: M
authors.lastname: Sajin
authors.affiliation: Department of Pathology, Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Mariana
authors.initials: M
authors.lastname: Costache
authors.affiliation: Department of Pathology, Emergency University Hospital, Bucharest, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Dumitru
authors.affiliation: Department of Pathology, Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Anca Mihaela
authors.initials: AM
authors.lastname: Lazaroiu
keywords: extranodal Hodgkin's lymphoma; immunohistochemistry; primary breast lymphoma