title: The stereoselective formation of highly substituted CF3-dihydropyrans as versatile building blocks.
abstract: The highly enantioselective dienamine-mediated formation of 5-bromo-6-(trifluoromethyl)-3,4-dihydro-2H-pyrans from α,β-unsaturated aldehydes and α-bromo-(trifluoromethyl)-enones employing a C2-symmetric aminocatalyst is described. The products are demonstrated to be applicable in coupling reactions directly onto the ring, thereby granting access to a broad scope of highly substituted 6-(trifluoromethyl)-dihydropyran compounds.
authors.affiliation: Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark. kaj@chem.au.dk.
authors.forename: Bjarke S
authors.initials: BS
authors.lastname: Donslund
authors.forename: Alicia
authors.initials: A
authors.lastname: Monleón
authors.forename: Jesper
authors.initials: J
authors.lastname: Larsen
authors.forename: Lise
authors.initials: L
authors.lastname: Ibsen
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen