title: A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel (Anguilla anguilla).
abstract: The European eel (Anguilla anguilla) is a facultatively catadromous fish species with a complex life cycle. Its current population status is alarming: recruitment has decreased drastically since the 1980s and its stock is still considered to be outside safe biological limits. Although there is no consensus on the reasons for this situation, it is currently thought to have resulted from a combination of different stressors, including anthropogenic contaminants. To deepen our understanding of the processes leading to the accumulation of lipophilic organic contaminants in yellow eels (i.e. the feeding, continental growth stage), we developed a physiologically based toxicokinetic model using our own data and values from the literature. Such models can predict the uptake and distribution of water-borne organic chemicals in the whole fish and in different tissues at any time during exposure. The predictive power of the model was tested against experimental data for six chemicals with n-octanol-water partitioning coefficient (log Kow) values ranging from 2.13-4.29. Model performance was excellent, with a root mean squared error of 0.28 log units. This model has the potential to help identify suitable habitats for restocking under eel management plans.
authors.affiliation: Department of Ecosystem Analysis, Institute for Environmental Research, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Brinkmann
authors.affiliation: Thünen Institute of Fisheries Ecology, Hamburg, Germany.
authors.forename: Marko
authors.initials: M
authors.lastname: Freese
authors.affiliation: Thünen Institute of Fisheries Ecology, Hamburg, Germany.
authors.forename: Jan-Dag
authors.initials: JD
authors.lastname: Pohlmann
authors.affiliation: Thünen Institute of Fisheries Ecology, Hamburg, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Kammann
authors.affiliation: Environmental Biology and Chemodynamics, Institute for Environmental Research, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Preuss
authors.affiliation: Federal Institute of Hydrology (BFG), Department G3: Biochemistry, Ecotoxicology, Koblenz, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Buchinger
authors.affiliation: Federal Institute of Hydrology (BFG), Department G3: Biochemistry, Ecotoxicology, Koblenz, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Reifferscheid
authors.affiliation: Thünen Institute of Fisheries Ecology, Hamburg, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Beiermeister
authors.affiliation: Thünen Institute of Fisheries Ecology, Hamburg, Germany.
authors.forename: Reinhold
authors.initials: R
authors.lastname: Hanel
authors.affiliation: Department of Ecosystem Analysis, Institute for Environmental Research, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China; College of Resources and Environmental Science, Chongqing University, Chongqing, China; Key Laboratory of Yangtze Water Environment, Ministry of Education, Tongji University, Shanghai 200092, China. Electronic address: Henner.hollert@bio5.rwth-aachen.de.
authors.forename: Henner
authors.initials: H
authors.lastname: Hollert
mesh_terms: D000811:Anguilla / Q000378:metabolism*; D000818:Animals; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D009930:Organic Chemicals / Q000378:metabolism*; D066007:Toxicokinetics; D014874:Water Pollutants, Chemical / Q000378:metabolism*
chemical_list: D009930:Organic Chemicals; D014874:Water Pollutants, Chemical
keywords: ADME; BCF; Bioconcentration; Organic pollutants; PBTK