title: [Role of activation of lipid peroxidation in the mechanisms of cardiovascular disease system under the action of heavy metals in the experiment].
abstract: The main anthropogenic air pollutants are heavy metals, World Health Organization related to toxic substances hazard class 1. Penetrating into the body in different ways, metals have a strong toxic effect on all body systems, but one of the most vulnerable, due to a number of reasons, is the cardiovascular system. There are many mechanisms of pathogenic influence of xenobiotics, leading to the development of disorders of the cardiovascular system, but our attention was attracted by the ability of metals to realize their negative effects through the activation of free radical. To confirm this assumption, it was necessary to conduct a pilot study of the effect of antioxidants in long-term effect of heavy metals. As an antioxidant agent used melatonin. Investigation of the state of systemic hemodynamics is to determine the mean arterial pressure, specific peripheral vascular resistance, stroke index and cardiac index. The intensity of free radical concentration was estimated by malondialdehyde and hydroperoxides in the blood of animals. The results of experimental studies revealed that prolonged intake of heavy metals (cobalt, cadmium and mercury) leads to the development of marked hemodynamic disturbances, combined with a sharp increase in the level of lipid peroxidation products in the blood. Melatonin under intoxication by heavy metals significantly reduced hypertensive effect of heavy metals on systemic hemodynamics, which together with a reduction of lipid peroxidation processes allows us to consider the activation of lipid peroxidation one of the major pathogenic factor in the development of hemodynamic disorders in conditions of heavy metal poisoning.
authors.forename: A K
authors.initials: AK
authors.lastname: Mitsiev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005609:Free Radicals / Q000097:blood; D000075322:Heavy Metal Poisoning; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology*; D015227:Lipid Peroxidation; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D019216:Metals, Heavy / Q000097:blood; D011041:Poisoning / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D019216:Metals, Heavy; D008550:Melatonin