title: Polymorphisms of OPG and their relation to the mineral density of bones in pre- and postmenopausal women.
abstract: OBJECTIVE
  The aim of the study was to evaluate the frequency of gene polymorphisms OPG -163A/G, -950T/C and 1181G/C, assessing their relations with the clinical parameters of osseous turnover and the degree of postmenopausal osteoporosis.
  
  
  METHODS
  The study included 800 women of postmenopausal (505) and reproductive (295) age from Poland. The postmenopausal group included women with osteoporosis and osteopenia, as well as healthy individuals. All the women of reproductive age were healthy. The frequency of the tested gene polymorphisms was evaluated within the group where BMD (bone mineral density) was marked and also in the control group.
  
  
  METHODS
  The frequencies of the polymorphisms of OPG genotypes in the women were characteristic of the population.
  
  
  RESULTS
  OPG -950T/C polymorphism has been associated with body weight and birth weight. OPG 1181G/C and OPG -163A/G polymorphisms have been associated not only with body weight and birth weight, but also with reduced bone density and an increased risk of postmenopausal osteoporosis.
  
  
  CONCLUSIONS
  Evaluation of the polymorphism -950T/C of the OPG gene showed that the CC genotype may appear as an increased risk factor for the faster loss of bone mass and the onset of osteoporosis in Polish postmenopausal women. This polymorphism may be a genetic marker that is responsible for the development of osteoporosis. The homozygous genotypes of polymorphisms 1181G/C and -163A/G of the OPG gene may play a role in increased risks of osteoporosis and may be linked to the birth weights of women.
authors.affiliation: Department of Histology and Embryology, Medical University of Silesia, SMDZ in Zabrze, Poland. Electronic address: metabolizm.db@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Boroń
authors.affiliation: Department of Orthopaedics, Traumatology and Orthopaedic Oncology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Kotrych
authors.affiliation: Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, University of Medical Sciences, Poznan, Poland; Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants, Poznan, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Bartkowiak-Wieczorek
authors.affiliation: Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University, Szczecin, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Uzar
authors.affiliation: Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, University of Medical Sciences, Poznan, Poland; Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants, Poznan, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Bogacz
authors.affiliation: Department of Orthopaedics, Traumatology and Orthopaedic Oncology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Kamiński
mesh_terms: D000328:Adult; D015519:Bone Density / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D053244:Osteoprotegerin / Q000235:genetics*; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000235:genetics*; D017697:Premenopause / Q000235:genetics*
chemical_list: D053244:Osteoprotegerin
keywords: Age; Females; Osteoporosis; Osteoprotegerin; Polymorphism