title: T-cell receptors modify neuronal function in the central nervous system.
abstract: Recent published findings have shown that many proteins discovered in the immune system and residing on immune cells with well established immune-related functions are also found in neurons of the central nervous system. These studies have uncovered a rich variety of neuronal functions attributed to these immune proteins. This review will focus on two key interacting protein complexes that previously were known for adaptive immune reactions, the major histocompatability complex and the T-cell receptor complex. We will review where these immune proteins are expressed in the CNS and their neuronal function.
authors.affiliation: Department of Biology, Centre for Biomedical Research, University of Victoria, Canada.
authors.forename: Pragya
authors.initials: P
authors.lastname: Komal
authors.affiliation: Department of Biology, Centre for Biomedical Research, University of Victoria, Canada. Electronic address: raad@uvic.ca.
authors.forename: Raad
authors.initials: R
authors.lastname: Nashmi
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology*; D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D009474:Neurons / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*
chemical_list: D011948:Receptors, Antigen, T-Cell
keywords: Central nervous system; Glutamate receptors; Immune proteins; Nicotinic acetylcholine receptors