title: New dammarane and ursane-type triterpenoids from the flower of Ixora coccinea Linn.
abstract: Two new esters of dammarane triterpenoids ixorene isovalerate (1), ixorene 3',8'-dimethyloctanoate (2) and a new ursane-type triterpenoids Ixoroid acid (3) were isolated from the methanolic extract of flowers of Ixora coccinea Linn., along with the three known constituents. The structures of compounds 1 and 3 were elucidated on the basis of extensive 1D,2D NMR studies and mass spectrometry as 17β-dammara-12,20-diene-3β-isovelarate and 3β-hydroxy-18β-urs-12ene-29β-oic acid, respectively, whereas 2 was identified as 17β-dammara-12,20-diene-3β-3',8'-dimethyloctanoate through (1)H NMR and mass spectral data. Compounds 1, 2, 4 and 5 were evaluated for their in vitro cytotoxic activity, which exhibited weak activity against the 3T3, PC3 and HeLa cell lines with the IC50 value >30 μM. Antioxidant results of 1 - 5 revealed that only compound 5 showed antioxidant activity in DPPH radical scavenging inhibition with the IC50 1.31 × 10(- 6) ± 0.005 μm mL(- 1). Both activities are the first records of these isolated compounds from the flowers of Ixora coccinea Linn.
authors.affiliation: a Department of Chemistry , Federal Urdu University of Arts, Sciences and Technology, Gulshan-e-Iqbal, Science Campus , Karachi 75300 , Pakistan.
authors.forename: Ambreen
authors.initials: A
authors.lastname: Ikram
authors.affiliation: a Department of Chemistry , Federal Urdu University of Arts, Sciences and Technology, Gulshan-e-Iqbal, Science Campus , Karachi 75300 , Pakistan.
authors.forename: Muhammad Ali
authors.initials: MA
authors.lastname: Versiani
authors.affiliation: a Department of Chemistry , Federal Urdu University of Arts, Sciences and Technology, Gulshan-e-Iqbal, Science Campus , Karachi 75300 , Pakistan.
authors.forename: Amna
authors.initials: A
authors.lastname: Khatoon
authors.affiliation: a Department of Chemistry , Federal Urdu University of Arts, Sciences and Technology, Gulshan-e-Iqbal, Science Campus , Karachi 75300 , Pakistan.
authors.forename: Salman Khalid
authors.initials: SK
authors.lastname: Ahmed
authors.affiliation: a Department of Chemistry , Federal Urdu University of Arts, Sciences and Technology, Gulshan-e-Iqbal, Science Campus , Karachi 75300 , Pakistan.
authors.forename: Samina Abdul
authors.initials: SA
authors.lastname: Sattar
authors.affiliation: b HEJ Research Institute of Chemistry , International Center for Chemical and Biological Sciences, University of Karachi , Karachi 75270 , Pakistan.
authors.forename: Shaheen
authors.initials: S
authors.lastname: Faizi
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification; D035264:Flowers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D019666:Rubiaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D000097669:Dammaranes; D053978:Pentacyclic Triterpenes
chemical_list: D000975:Antioxidants; D014315:Triterpenes; D000097669:Dammaranes; C000610649:ixorene 3',8'-dimethyloctanoate; C000610648:ixorene isovalerate; C000606873:ursane; D053978:Pentacyclic Triterpenes
keywords: antioxidant activity; cytotoxic activity; dammarane triterpenoid; ixorene 3′,8′-dimethyloctanoate; ixorene isovalerate