title: Functional System and Areal Organization of a Highly Sampled Individual Human Brain.
abstract: Resting state functional MRI (fMRI) has enabled description of group-level functional brain organization at multiple spatial scales. However, cross-subject averaging may obscure patterns of brain organization specific to each individual. Here, we characterized the brain organization of a single individual repeatedly measured over more than a year. We report a reproducible and internally valid subject-specific areal-level parcellation that corresponds with subject-specific task activations. Highly convergent correlation network estimates can be derived from this parcellation if sufficient data are collected-considerably more than typically acquired. Notably, within-subject correlation variability across sessions exhibited a heterogeneous distribution across the cortex concentrated in visual and somato-motor regions, distinct from the pattern of intersubject variability. Further, although the individual's systems-level organization is broadly similar to the group, it demonstrates distinct topological features. These results provide a foundation for studies of individual differences in cortical organization and function, especially for special or rare individuals. VIDEO ABSTRACT.
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: laumannt@wusm.wustl.edu.
authors.forename: Timothy O
authors.initials: TO
authors.lastname: Laumann
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Evan M
authors.initials: EM
authors.lastname: Gordon
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Babatunde
authors.initials: B
authors.lastname: Adeyemo
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Snyder
authors.affiliation: Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Sung Jun
authors.initials: SJ
authors.lastname: Joo
authors.affiliation: Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Mei-Yen
authors.initials: MY
authors.lastname: Chen
authors.affiliation: Department of Psychology, Washington University in St. Louis, St. Louis, MO 63110, USA.
authors.forename: Adrian W
authors.initials: AW
authors.lastname: Gilmore
authors.affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychology, Washington University in St. Louis, St. Louis, MO 63110, USA.
authors.forename: Kathleen B
authors.initials: KB
authors.lastname: McDermott
authors.affiliation: VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Nelson
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Nico U F
authors.initials: NU
authors.lastname: Dosenbach
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Bradley L
authors.initials: BL
authors.lastname: Schlaggar
authors.affiliation: Center for Investigating Healthy Minds at the Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
authors.forename: Jeanette A
authors.initials: JA
authors.lastname: Mumford
authors.affiliation: Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA; Imaging Research Center, University of Texas at Austin, Austin, TX 78712, USA; Department of Psychology, Stanford University, Stanford, CA 94305, USA.
authors.forename: Russell A
authors.initials: RA
authors.lastname: Poldrack
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Petersen
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods* / Q000592:standards; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance / Q000502:physiology