title: Performance assessments of vertically aligned carbon nanotubes multi-electrode arrays using Cath.a-differentiated (CAD) cells.
abstract: In this work, Cath.a-differentiated (CAD) cells were used in place of primary neuronal cells to assess the performance of vertically aligned carbon nanotubes (VACNTs) multi-electrode arrays (MEA). To fabricate high-performance MEA, VACNTs were directly grown on graphene/Pt electrodes via plasma enhanced chemical deposition technique. Here, graphene served as an intermediate layer lowering contact resistance between VACNTs and Pt electrode. In order to lower the electrode impedance and to enhance the cell adhesion, VACNTs-MEAs were treated with UV-ozone for 20 min. Impedance of VACNTs electrode at 1 kHz frequency exhibits a reasonable value (110 kΩ) for extracellular signal recording, and the signal to noise ratio the is good enough to measure low signal amplitude (15.7). Spontaneous firing events from CAD cells were successfully measured with VACNTs MEAs that were also found to be surprisingly robust toward the biological interactions.
authors.affiliation: Department of Physics, Chonbuk National University, Chonju 561-756, Korea. Advanced Materials Division, Korea Research Institute of Chemical Technology, Daejeon 305-343, Korea.
authors.forename: Du Won
authors.initials: du W
authors.lastname: Jeong
authors.forename: Jongjin
authors.initials: J
authors.lastname: Jung
authors.forename: Gook Hwa
authors.initials: GH
authors.lastname: Kim
authors.forename: Cheol-Soo
authors.initials: CS
authors.lastname: Yang
authors.forename: Ju Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Sang Don
authors.initials: SD
authors.lastname: Jung
authors.forename: Jeong-O
authors.initials: JO
authors.lastname: Lee
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003584:Cytological Techniques / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D004594:Electrophysiology / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006108:Graphite / Q000737:chemistry; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D006108:Graphite