title: Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012.
abstract: BACKGROUND
  A surgical site infection (SSI) is the most common nosocomial infection after surgery and is the third most common infection in hospitalized patients. The aim of this study was to asses minimum inhibitory concentration (MIC) of the causing agents of SSI and antimicrobial susceptibility patterns.
  
  
  METHODS
  This cross-sectional study was done in three referral hospitals in North of Iran during 2011-2012. The samples were taken one month after orthopedic, abdominal, cesarean section surgery and coronary artery bypass graft (CABG) in patients with scores compatible to SSIs criteria. The sample was sent for bacteriologic culture and MIC determination for positive cases by broth microdilution method. The data were collected and analyzed.
  
  
  RESULTS
  From 103 positive cases S. aureus, E.coli and coagulase negative staphylococci were the most common isolated agents as 29.12%, 23.3% and 21.3%, respectively. S. aureus was sensitive to vancomycin (70%), amikacin (70%) and teicoplanin (76.6%) and cogulase negative staphylococci was sensitive to vancomycin (68.1%) and teicoplanin (72.6%) and E.coli to amikacin (95.83%) and imipenem and meropenem (66.66%). P.aeroginosa showed no sensitivity to cefepime and was sensitive to imipenem (93.75%) and meropenem (81.25%).
  
  
  CONCLUSIONS
  The most important point is worrisome problem of the increased MIC of S. aureus to vancomycin that causes difficult use in the treatment of staphylococcal SSIs. In spite of resistance of micro-organisms to cephalosporins, gram negative organisms had low MIC to carbapenemes especially P.aeroginosa although the rate of its MIC is increasing.
authors.affiliation: Department of Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Alikhani
authors.affiliation: Department of Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Farhang
authors.initials: F
authors.lastname: Babamahmoodi
authors.affiliation: Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Laleh
authors.initials: L
authors.lastname: Foroutan Alizadegan
authors.affiliation: Ghaemshahr Razi Hospital, Ghaemshahr, Iran.
authors.forename: Arman
authors.initials: A
authors.lastname: Shojaeefar
authors.affiliation: Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Babamahmoodi
keywords: Antibiotics; Minimal Inhibitory Concentration; Resistance; Surgical site infection