title: Bisphosphonate associated osteomyelitis of the jaw in patients with bony exposure: prevention, a new way of thinking.
abstract: Objective There is strong evidence of a link between the use of systemic bisphosphonates (BPs) and osteonecrosis of the jaw, especially in cancer patients. Among risk factors for BRONJ, tooth extraction and immune suppressive drugs seem to have significant role on bone healing. Therefore, the importance of these parameters in development of BRONJ was reviewed in this retrospective study in two maxillofacial surgery units. Material and Methods From 2007 to 2012, 46 patients on bisphosphonate who had developed oral bony lesions participated in this study. The pharmacological exposure, comorbidities, maxillofacial findings, types of treatment and outcome data were collected from clinical and radiological records. Results The most frequently used BP was alendronate (67%). Tooth extraction was reported in 61% of patients with BRONJ. Systemic corticosteroids were prescribed in 35 cases (76%) as an adjuvant for BP. Patients on corticosteroids had a lower probability of bony lesion healing (p<0.05) than patients without corticosteroids. Of the 46 patients who underwent conservative treatments, only ten were completely healed (21%). Conclusions Beside tooth extraction, corticosteroids were shown to be an implant risk factor for low rate of bone healing and hence the development of BRONJ. The outcome of conservative treatment was uncertain and this emphasizes the importance of prevention.
authors.affiliation: Department of Oral & Maxillofacial Surgery, Bergen, Norway.
authors.forename: Arezo
authors.initials: A
authors.lastname: Tardast
authors.affiliation: Department of Oral & Maxillofacial Surgery, University Hospital, Linköping, Sweden.
authors.forename: Reine
authors.initials: R
authors.lastname: Sjöman
authors.affiliation: Department of Oral & Maxillofacial Surgery, Bergen, Norway.
authors.forename: Sigbjørn
authors.initials: S
authors.lastname: Løes
authors.affiliation: Department of Oral & Maxillofacial Surgery, University Hospital, Linköping, Sweden.
authors.forename: Jahan
authors.initials: J
authors.lastname: Abtahi
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000368:Aged; D000369:Aged, 80 and over; D019386:Alendronate / Q000009:adverse effects; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000517:prevention & control*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D017102:Fracture Healing / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000139:chemically induced* / Q000517:prevention & control*; D012189:Retrospective Studies; D012307:Risk Factors; D014081:Tooth Extraction / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D019386:Alendronate