title: Anti-B lymphocyte immunotherapy is associated with improvement of periodontal status in subjects with rheumatoid arthritis.
abstract: OBJECTIVE
  Rheumatoid arthritis (RA) and periodontitis present many similar features. The benefits of anti-B lymphocyte therapy (rituximab) on reducing tissue resorption in RA prompted us to assess its potential efficacy on the periodontal status of patients with RA treated with rituximab.
  
  
  METHODS
  Periodontal status was assessed in 21 subjects with RA, divided into two groups: Group I consisted in 11 subjects assessed before their first infusion of rituximab and again 6 months later. Five of them were also assessed for up to 4 years after their first rituximab infusion. The 10 subjects in group II had received more than two courses of two rituximab infusions at the time of periodontal assessment.
  
  
  RESULTS
  Pocket depth and attachment loss were significantly decreased 6 months after treatment with rituximab in group I. The periodontal status of the five subjects from group I followed for up to 48 months after rituximab treatment was improved irrespective of the clinical parameter observed. Patients from group II had a better periodontal status than patients from group I before treatment with rituximab.
  
  
  CONCLUSIONS
  Anti-B lymphocyte therapy could be beneficial to improve periodontitis suggesting a major role of B cells in this disease.
authors.affiliation: EA2216, INSERM ESPRI, ERI29, Université de Brest, Brest, France.|LabEx IGO, Brest, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Coat
authors.affiliation: EA2216, INSERM ESPRI, ERI29, Université de Brest, Brest, France.|LabEx IGO, Brest, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Demoersman
authors.affiliation: Department of Dentistry, Brest University Medical School Hospital, Brest, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Beuzit
authors.affiliation: EA2216, INSERM ESPRI, ERI29, Université de Brest, Brest, France.|LabEx IGO, Brest, France.|Department of Rheumatology, Brest University Medical School Hospital, Brest, France.
authors.forename: Divi
authors.initials: D
authors.lastname: Cornec
authors.affiliation: EA2216, INSERM ESPRI, ERI29, Université de Brest, Brest, France.|LabEx IGO, Brest, France.|Department of Rheumatology, Brest University Medical School Hospital, Brest, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Devauchelle-Pensec
authors.affiliation: EA2216, INSERM ESPRI, ERI29, Université de Brest, Brest, France.|LabEx IGO, Brest, France.|Department of Rheumatology, Brest University Medical School Hospital, Brest, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Saraux
authors.affiliation: EA2216, INSERM ESPRI, ERI29, Université de Brest, Brest, France.|LabEx IGO, Brest, France.|Department of Dentistry, Brest University Medical School Hospital, Brest, France.
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Pers
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology / Q000628:therapy*; D001402:B-Lymphocytes / Q000276:immunology*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007167:Immunotherapy; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications / Q000276:immunology / Q000628:therapy*; D011379:Prognosis; D000069283:Rituximab / Q000627:therapeutic use*
chemical_list: D018501:Antirheumatic Agents; D000069283:Rituximab
keywords: anti-B lymphocyte; bone resorption; immunotherapy; periodontitis; rheumatoid arthritis