title: The 1-h oral glucose tolerance test glucose and insulin values are associated with markers of clinical deterioration in cystic fibrosis.
abstract: OBJECTIVE
  Cystic fibrosis (CF) is associated with the emergence of CF-related diabetes (CFRD). CFRD is associated with increased risk of accelerated weight and/or lung function loss (clinical degradation). Data in the CF pediatric population reported an association between higher 60-min oral glucose tolerance test (OGTT) plasma glucose values and reduced lung function. Our objective was to evaluate the relationship between the 60-min OGTT insulin and glucose values and markers of clinical degradation in adult patients with CF.
  
  
  METHODS
  This study was based on an ongoing observational cohort of CF adult patients (≥18 years). All patients underwent a 2-h OGTT with 30-min interval sample measurements. Plasma insulin and glucose levels were measured. Adult patients (N = 240) were categorized based on the 60-min OGTT median values of glucose (G60, 11.0 mmol/L) and/or insulin (I60, 43.4 μU/mL).
  
  
  RESULTS
  A negative association was observed between the 60-min OGTT glucose value and pulmonary function (FEV1; P = 0.001), whereas 60-min OGTT insulin values were positively associated with BMI (P = 0.004). Patients with high G60 values displayed lower FEV1 than patients with low G60 values (P = 0.025). Patients with higher I60 values demonstrated higher values of both FEV1 (P = 0.022) and BMI (P = 0.003) than patients with low I60 values. More importantly, when adjusting for BMI, the difference in FEV1 between both groups no longer existed (P = 0.166).
  
  
  CONCLUSIONS
  Both insulin and glucose values at 60-min OGTT are associated with indicators of clinical degradation in adult patients with CF. Future prospective analyses are essential in establishing the clinical utility of these indicators.
authors.affiliation: Institut de recherches cliniques de Montréal, 110 avenue des Pins Ouest, Montréal, QC, H2W 1R7, Canada. adele.coriati@ircm.qc.ca.|Department of Nutrition, Université de Montréal, Montréal, QC, H3T 1A8, Canada. adele.coriati@ircm.qc.ca.
authors.forename: Adèle
authors.initials: A
authors.lastname: Coriati
authors.affiliation: Institut de recherches cliniques de Montréal, 110 avenue des Pins Ouest, Montréal, QC, H2W 1R7, Canada.|Department of Nutrition, Université de Montréal, Montréal, QC, H3T 1A8, Canada.
authors.forename: Sophie
authors.initials: S
authors.lastname: Ziai
authors.affiliation: Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, QC, H2W 1T8, Canada.
authors.forename: Annick
authors.initials: A
authors.lastname: Lavoie
authors.affiliation: Institut de recherches cliniques de Montréal, 110 avenue des Pins Ouest, Montréal, QC, H2W 1R7, Canada.|Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, QC, H2W 1T8, Canada.|Department of Medicine, Université de Montréal, Montréal, QC, H3T 1J4, Canada.
authors.forename: Yves
authors.initials: Y
authors.lastname: Berthiaume
authors.affiliation: Institut de recherches cliniques de Montréal, 110 avenue des Pins Ouest, Montréal, QC, H2W 1R7, Canada.|Department of Nutrition, Université de Montréal, Montréal, QC, H3T 1A8, Canada.|Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, QC, H2W 1T8, Canada.|Department of Medicine, Université de Montréal, Montréal, QC, H3T 1J4, Canada.
authors.forename: Rémi
authors.initials: R
authors.lastname: Rabasa-Lhoret
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications / Q000473:pathology; D003920:Diabetes Mellitus / Q000097:blood / Q000209:etiology*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Body mass index; Cystic fibrosis-related diabetes; Glucose; Insulin; Oral glucose tolerance test; Pulmonary function