title: Stereoselective α-indolylation of enals via an organocatalytic formal cross-coupling with indoles.
abstract: We report a novel organocatalytic one-pot cascade bromination-Michael-type Friedel-Crafts alkylation dearomatization-nucleophilic rearrangement aromatization cascade process for the direct α-indolylation of unfunctionalized enals from readily available indoles with good yields and high E selectivity. The simplicity and practicality of its high efficiency for formation of a new C(sp(2))-C(sp(2)) bond constitute the most attractive advantage of this reaction.
authors.affiliation: East China University of Science & Technology, Shanghai, China. xhyu@ecust.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.forename: Lei
authors.initials: L
authors.lastname: Ju
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Hongmei
authors.initials: H
authors.lastname: Ma
authors.forename: Xinhong
authors.initials: X
authors.lastname: Yu
mesh_terms: D002384:Catalysis; D006860:Hydrogen Bonding; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010636:Phenols / Q000737:chemistry; D011522:Protons; D011789:Quantum Theory; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D007211:Indoles; D010636:Phenols; D011522:Protons