title: [Effect evaluation of allergen specific immunotherapy in patients with allergic rhinitis and asthma].
abstract: OBJECTIVE
  To evaluate the effect of allergen specific immunotherapy (SIT) in patients with allergic rhinitis and asthma. METHOD A total of 68 patients with allergic rhinitis and asthma sensitized to dust mite were recruited into the study. They were randomly divided into two groups: SIT group n = 34 and symptomatic therapy (ST) group: n = 34. Patients in ST group received medication to treat, the symptoms, patients in SIT group received medication and 3 years of standardized allergen vaccine therapy. Evaluation index of therapy includes: rhinitis symptoms score, asthma symptoms score, drug score, skin prick test, serum specificity IgE (sIgE) , peripheral eosinophil (Eos) counting, lung function. The new sensitinogen rate was also assessed.
  
  
  RESULTS
  Clinical symptom scores, drug scores, lung function, blood eosinophil numbers and skin test result were all improved significantly after 3-year treatment in SIT group compared to those in ST group (P < 0.01). Although the level of serum slgE was decreased,there exited no statistic diferences between two groups. Only 8.8% patients have the new sensitization in SIT group, and 52.9% in ST group. There were no serious adverse reactions in treatment process.
  
  
  CONCLUSIONS
  SIT for patients with AR and asthma can obtain excellent clinical efficacy.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Song
authors.forename: Hua
authors.initials: H
authors.lastname: Xie
authors.forename: Ruonan
authors.initials: R
authors.lastname: Chai
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Lin
authors.forename: Lingling
authors.initials: L
authors.lastname: Song
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D003888:Desensitization, Immunologic; D004804:Eosinophils; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D039981:Pyroglyphidae; D065631:Rhinitis, Allergic / Q000188:drug therapy*; D012680:Sensitivity and Specificity; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E