title: Orthology for comparative genomics in the mouse genome database.
abstract: The mouse genome database (MGD) is the model organism database component of the mouse genome informatics system at The Jackson Laboratory. MGD is the international data resource for the laboratory mouse and facilitates the use of mice in the study of human health and disease. Since its beginnings, MGD has included comparative genomics data with a particular focus on human-mouse orthology, an essential component of the use of mouse as a model organism. Over the past 25 years, novel algorithms and addition of orthologs from other model organisms have enriched comparative genomics in MGD data, extending the use of orthology data to support the laboratory mouse as a model of human biology. Here, we describe current comparative data in MGD and review the history and refinement of orthology representation in this resource.
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME, 04609, USA, mary.dolan@jax.org.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Dolan
authors.forename: Richard M
authors.initials: RM
authors.lastname: Baldarelli
authors.forename: Susan M
authors.initials: SM
authors.lastname: Bello
authors.forename: Li
authors.initials: L
authors.lastname: Ni
authors.forename: Monica S
authors.initials: MS
authors.lastname: McAndrews
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Bult
authors.forename: James A
authors.initials: JA
authors.lastname: Kadin
authors.forename: Joel E
authors.initials: JE
authors.lastname: Richardson
authors.forename: Martin
authors.initials: M
authors.lastname: Ringwald
authors.forename: Janan T
authors.initials: JT
authors.lastname: Eppig
authors.forename: Judith A
authors.initials: JA
authors.lastname: Blake
mesh_terms: D000483:Alleles; D000818:Animals; D030541:Databases, Genetic / Q000266:history*; D004195:Disease Models, Animal; D016678:Genome; D023281:Genomics / Q000266:history / Q000379:methods*; D005838:Genotype; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D051379:Mice; D058977:Molecular Sequence Annotation; D010641:Phenotype; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid