title: Genetic polymorphism of miR-146a is associated with gastric cancer risk: a meta-analysis.
abstract: Several studies have investigated the associations between miR-146a rs2910164 and gastric cancer (GC) risk, but results have been inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. PubMed and China National Knowledge Infrastructure searches were carried out for relevant studies published before July 2014. Meta-analysis was performed with the stata, version 11.0. A total of seven case-control studies, including 3283 cases and 4535 controls, were selected. A significant association was found between rs2910164 and GC risk under all genetic models (CC vs. GG, OR = 0.76, 95% CI = 0.66-0.87; CC vs. GC+GG, OR = 0.84, 95% CI = 0.71-0.99; CC+GC vs. GG, OR = 0.82, 95% CI = 0.73-0.91) for the total data. In the subgroup analysis by ethnicity, statistically significant association was found in Asian. This meta-analysis suggested that the miR-146a rs2910164 was a risk factor for developing GC.
authors.affiliation: Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Orthopedic Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: M
authors.initials: M
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs
keywords: gastric cancer; meta-analysis; miR-146a; polymorphism