title: DeNovo NT Particulated Juvenile Cartilage Implant.
abstract: Biological repair of focal chondral defects represents a significant clinical challenge as cartilage lacks intrinsic healing ability. Although it can be difficult to measure the objective success of cartilage repair techniques, the primary objective is symptom relief leading to less pain and improved function for the patient. Likely, the most important key to success is proper clinical indications. Second to this, the type of cartilage treatment utilized should be based on lesion location, size, depth, and other patient factors. One such treatment is DeNovo Natural Tissue. This method relies on the ability of juvenile chondrocytes to migrate from cartilage explants after being secured in a cartilage defect. Although approximately 8700 cases have been performed since 2007, long-term clinical outcomes are not yet available. However, basic science and early clinical data are promising.
authors.affiliation: Department of Orthopedics, RUSH University Medical Center, Chicago, IL.
authors.forename: Adam B
authors.initials: AB
authors.lastname: Yanke
authors.forename: Annemarie K
authors.initials: AK
authors.lastname: Tilton
authors.forename: Nathan G
authors.initials: NG
authors.lastname: Wetters
authors.forename: David B
authors.initials: DB
authors.lastname: Merkow
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Cole
mesh_terms: D002358:Cartilage, Articular / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation*; D006801:Humans; D007719:Knee Joint / Q000601:surgery*; D014184:Transplantation, Homologous / Q000379:methods*