title: The prognostic role of neutrophils to lymphocytes ratio and platelet count in gastric cancer: A meta-analysis.
abstract: BACKGROUND
  Systemic inflammatory response was reported to be associate with a poor survival in gastric cancer. However, these results remain inconsistent. The purpose of this meta-analysis was to evaluate the prognostic role of neutrophils to lymphocytes ratio (NLR) and platelet count in gastric cancer.
  
  
  METHODS
  Relevant studies were identified by searching PubMed, Embase and Cochrane Library. Data was pooled using a fixed-effects models or random-effects models.
  
  
  RESULTS
  A total of 29 studies were included for meta-analysis (19 for NLR, 10 for platelet count). Elevated NLR and platelet count were associated with an increased lymph node metastasis and serosal invasion (T3+T4) risk with individual ORs being 1.70 (95% CI: 1.05-2.75) and 2.93 (95% CI: 2.27-3.78), 1.62 (95% CI: 1.08-2.42) and 2.09 (95% CI: 1.57-2.77), respectively. The incidence of stage (III + IV) in elevated NLR group was higher than in normal NLR group (OR = 1.87, 95% CI: 1.48-2.35). The disease-free survival in patients with elevated NLR was markedly shorter (HR = 1.61; 95% CI: 1.28-1.94). For the overall survival, both indicators were strong predictors with individual HRs being 1.65 (95% CI: 1.47-1.83), 1.61 (95% CI: 1.35-1.86), respectively.
  
  
  CONCLUSIONS
  This meta-analysis suggests that elevated NLR and platelet count predict poor survival in patients with gastric cancer, and may provides some useful evidence for the clinical application of the two prognostic indicators in gastric cancer.
authors.affiliation: Department of Urology, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xin-Ji
authors.affiliation: Department of Medical Oncology, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yong-Gang
authors.affiliation: Department of Urology, People's Hosptial of Xuancheng City, Xuancheng, Anhui, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Xiao-Jun
authors.affiliation: Department of General Surgery, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xiao-Wu
authors.affiliation: Department of General Surgery, Baoshan Branch of Huashan Hospital, Fudan University, 1999 West Changjiang Road, Shanghai, 200431, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of General Surgery, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong, China. Electronic address: 1105405029@qq.com.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Da-Jian
mesh_terms: D006801:Humans; D018655:Lymphocyte Count; D009504:Neutrophils / Q000378:metabolism*; D010976:Platelet Count; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality*
keywords: Gastric cancer; Meta-analysis; Neutrophils to lymphocytes ratio; Platelet count; Prognosis