title: Association study between reward dependence and a functional BDNF polymorphism in adult women offspring of alcohol-dependent probands.
abstract: Thirty-five healthy adult women offspring of alcohol-dependent probands (AWOA) were compared with 63 healthy controls to test whether personality dimensions on the Temperament and Character Inventory questionnaire were associated with the brain-derived neurotrophic factor Val66Met polymorphism in offspring. We found a significantly lower reward dependence score in AWOA compared with the controls. The brain-derived neurotrophic factor Val66Met polymorphism may be involved in this difference as the lower reward dependence score was found only in AWOA carrying the Val allele.
authors.affiliation: aDepartment of Psychiatry, Robert Debré Hospital bC2S Laboratory (EA 6291), Reims Champagne-Ardenne University, Reims cCMME, Saint-Anne Hospital dNSERM U894, Psychiatry and Neurosciences Centre eParis Descartes University, Sorbonne Paris Cité, Paris fDepartment of Psychiatry, Corentin-Celton Hospital, Issy-les-Moulineaux, France.
authors.forename: Farid
authors.initials: F
authors.lastname: Benzerouk
authors.forename: Fabien
authors.initials: F
authors.lastname: Gierski
authors.forename: Delphine
authors.initials: D
authors.lastname: Raucher-Chéné
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ramoz
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
authors.forename: Arthur
authors.initials: A
authors.lastname: Kaladjian
authors.forename: Frédéric
authors.initials: F
authors.lastname: Limosin
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology*; D044466:Asian People / Q000235:genetics / Q000523:psychology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010552:Personality Assessment; D020641:Polymorphism, Single Nucleotide; D012201:Reward
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human