title: Large-Scale Brain Network Coupling Predicts Total Sleep Deprivation Effects on Cognitive Capacity.
abstract: Interactions between large-scale brain networks have received most attention in the study of cognitive dysfunction of human brain. In this paper, we aimed to test the hypothesis that the coupling strength of large-scale brain networks will reflect the pressure for sleep and will predict cognitive performance, referred to as sleep pressure index (SPI). Fourteen healthy subjects underwent this within-subject functional magnetic resonance imaging (fMRI) study during rested wakefulness (RW) and after 36 h of total sleep deprivation (TSD). Self-reported scores of sleepiness were higher for TSD than for RW. A subsequent working memory (WM) task showed that WM performance was lower after 36 h of TSD. Moreover, SPI was developed based on the coupling strength of salience network (SN) and default mode network (DMN). Significant increase of SPI was observed after 36 h of TSD, suggesting stronger pressure for sleep. In addition, SPI was significantly correlated with both the visual analogue scale score of sleepiness and the WM performance. These results showed that alterations in SN-DMN coupling might be critical in cognitive alterations that underlie the lapse after TSD. Further studies may validate the SPI as a potential clinical biomarker to assess the impact of sleep deprivation.
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lei
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing, PR China.
authors.forename: Yongcong
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing, PR China.
authors.forename: Lubin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing, PR China.
authors.forename: Tianye
authors.initials: T
authors.lastname: Zhai
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zou
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing, PR China.
authors.forename: Enmao
authors.initials: E
authors.lastname: Ye
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Jin
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China.
authors.forename: Wuju
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Clinical Psychology, Air-Force General Hospital, Beijing, PR China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Qi
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D003071:Cognition; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D012892:Sleep Deprivation / Q000000981:diagnostic imaging / Q000503:physiopathology