title: Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B.
abstract: Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.
authors.affiliation: Department of Bioorganic Mechanisms, Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine, Kyiv, Ukraine. vovk@bpci.kiev.ua.
authors.forename: Viacheslav V
authors.initials: VV
authors.lastname: Trush
authors.forename: Sergiy G
authors.initials: SG
authors.lastname: Kharchenko
authors.forename: Vsevolod Yu
authors.initials: VY
authors.lastname: Tanchuk
authors.forename: Vitaly I
authors.initials: VI
authors.lastname: Kalchenko
authors.forename: Andriy I
authors.initials: AI
authors.lastname: Vovk
mesh_terms: D047250:Calixarenes / Q000737:chemistry / Q000494:pharmacology*; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004952:Esters / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008958:Models, Molecular; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D013696:Temperature
chemical_list: D004791:Enzyme Inhibitors; D004952:Esters; D063065:Organophosphonates; D012709:Serum Albumin; D047250:Calixarenes; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1