title: Antiepileptic Drugs and Bone Health in Thai Children with Epilepsy.
abstract: Background: Epilepsy is the most common neurological disease in children. The patient must take antiepileptic drug for controlling the seizure at least 2 years. Many previous studies show the effect of antiepileptic drug to vitamin D status and bone health.
  
  
  OBJECTIVE
  To study the prevalence of vitamin D deficiency and bone mineral density in the children who are taking antiepileptic drug at least 6 months.
  
  
  METHODS
  Thirty epileptic children who are 3-18 years old with taking antiepileptic drug at least 6 months and 30 healthy children in the same age were performed to investigate serum 25-hydroxyvitamin D, calcium, phosphorus, magnesium, creatinine, alkaline phosphatase, albumin, parathyroid hormone, spot urine calcium, spot urine phosphorus, spot urine creatinine and bone mineral density between October 2012 to September 2013.
  
  
  RESULTS
  Seven epileptic children (23.3%), eight healthy children (26.7%) have vitamin D deficiency. Only 3 epileptic children who are cerebral palsy also have low bone mineral density. There is only statistical significant of decreased serum albumin (p-value = 0.03) and corrected serum calcium (p-value = 0.04) that reveal in epileptic children group.
  
  
  CONCLUSIONS
  Evaluation of serum 25-hydroxyvitamin D status and bone metabolism is essential in the treatment of childhood epilepsy.
authors.forename: Sudathip
authors.initials: S
authors.lastname: Paticheep
authors.forename: Chanisa
authors.initials: C
authors.lastname: Chotipanich
authors.forename: Khanittha
authors.initials: K
authors.lastname: Khusiwilai
authors.forename: Anuttara
authors.initials: A
authors.lastname: Wichaporn
authors.forename: Subsai
authors.initials: S
authors.lastname: Khongsaengdao
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood / Q000652:urine; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D015995:Prevalence; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology*
chemical_list: D000927:Anticonvulsants; D010281:Parathyroid Hormone; D014807:Vitamin D; D010758:Phosphorus; C104450:25-hydroxyvitamin D; D003404:Creatinine; D000469:Alkaline Phosphatase; D002118:Calcium