title: Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics.
abstract: NADPH oxidase (NOX) enzymes show great potential as therapeutic pharmacological targets. This Forum revolves around the roles of specific NOX isoforms in oxidative stress-mediated pathologies, available NOX antagonists/agonists as well as the potential side effects of NOX inhibition and the requisite identification of novel oxidative biomarkers as a measure of NOX activity in patients. In addition, an original article reports the discovery of a novel small molecule NOX2 inhibitor. Finally an attractive and innovative therapeutic approach for modulating NOX activity through the inhibition of the proton channel Hv1 is discussed.
authors.affiliation: 1 Department of Pathology, Dalhousie University , Halifax, Canada .
authors.forename: Karen
authors.initials: K
authors.lastname: Bedard
authors.affiliation: 1 Department of Pathology, Dalhousie University , Halifax, Canada .
authors.forename: Scott
authors.initials: S
authors.lastname: Whitehouse
authors.affiliation: 2 Department of Pathology and Immunology, Centre Médical Universitaire , University of Geneva, Geneva, Switzerland .
authors.forename: Vincent
authors.initials: V
authors.lastname: Jaquet
mesh_terms: D000818:Animals; D055808:Drug Discovery; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D019255:NADPH Oxidases / Q000627:therapeutic use*; D018384:Oxidative Stress
chemical_list: C510235:HVCN1 protein, human; D007473:Ion Channels; D019255:NADPH Oxidases