title: Surface Complexation-Based Biocompatible Magnetofluorescent Nanoprobe for Targeted Cellular Imaging.
abstract: We report the synthesis of a magnetofluorescent biocompatible nanoprobe-following room temperature complexation reaction between Fe3O4-ZnS nanocomposite and 8-hydroxyquinoline (HQ). The composite nanoprobe exhibited high luminescence quantum yield, low rate of photobleaching, reasonable excited-state lifetime, luminescence stability especially in human blood serum, superparamagnetism and no apparent cytotoxicity. Moreover, the nanoprobe could be used for spatio-controlled cell labeling in the presence of an external magnetic field. The ease of synthesis and cell labeling in vitro make it a suitable candidate for targeted bioimaging applications.
authors.affiliation: †Department of Chemistry and ‡Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
authors.forename: Satyapriya
authors.initials: S
authors.lastname: Bhandari
authors.affiliation: †Department of Chemistry and ‡Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
authors.forename: Rumi
authors.initials: R
authors.lastname: Khandelia
authors.affiliation: †Department of Chemistry and ‡Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
authors.forename: Uday Narayan
authors.initials: UN
authors.lastname: Pan
authors.affiliation: †Department of Chemistry and ‡Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Chattopadhyay
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D018613:Microscopy, Confocal; D015125:Oxyquinoline / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry; D011789:Quantum Theory; D017550:Spectroscopy, Fourier Transform Infrared; D013440:Sulfides / Q000737:chemistry; D014466:Ultraviolet Rays; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D058185:Magnetite Nanoparticles; D013440:Sulfides; D017967:Zinc Compounds; D015125:Oxyquinoline; C031238:zinc sulfide; D052203:Ferrosoferric Oxide
keywords: complexation reaction; magnetic nanoparticle; photoluminescence; quantum dots; targeted cellular imaging