title: A Statistical Method for Identifying Trait-Associated Copy Number Variants.
abstract: Copy number variants (CNVs), ranging in size from about one kilobase to several megabases, are DNA alterations of a genome that result in the cell having less or more than two copies of segments of the DNA. Such CNVs have been shown to be associated with many complex phenotypes, ranging from diseases to gene expressions. Novel methods have been developed for identifying CNVs both at the individual and at the population level. However, methods for testing CNV association are limited. Most available methods employ a two-step approach, where CNVs carried by the samples are identified first and then tested for association. However, the results of such tests depend on the threshold used for CNV identification and also the number of CNVs to be tested. We developed a method, CNVtest, to directly identify the trait-associated CNVs without the need of identifying sample-specific CNVs. We show that CNVtest asymptotically controls the type I error rate and identifies true trait-associated CNVs with a high probability. We demonstrate the methods using simulations and an application to identify the CNVs that are associated with population differentiation.
authors.affiliation: Department of Statistics, North Carolina State University, Raleigh, N.C., USA.
authors.forename: Jessie
authors.initials: J
authors.lastname: Jeng
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.forename: Hongzhe
authors.initials: H
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics; D003198:Computer Simulation; D056915:DNA Copy Number Variations / Q000235:genetics*; D004194:Disease / Q000235:genetics; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease; D006801:Humans; D019655:Quantitative Trait, Heritable; D013223:Statistics as Topic / Q000379:methods*; D044465:White People / Q000235:genetics