title: Development and Detection of Kidd Antibodies.
abstract: Kidd antibodies have a reputation for causing hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. We present a case of an untransfused male patient who developed anti-Kidd(a) (Jk(a)) antibodies after receiving an allogenic renal transplant. The formation of this antibody was associated with exposure to the Kidd antigen expressed on the tubular epithelium of the transplanted kidney. The 59-year-old white male patient had received a cadaveric renal transplant at our clinic and returned 5 years later with proteinuria and elevated serum creatinine levels, consistent with nephrotic syndrome. We review the expression of Kidd antigens and the development and detection of Kidd antibodies, and discuss the case reports from the literature of Kidd antibodies associated with kidney-graft rejection that suggest Kidd antigens play a role as a minor histocompatibility antigen.
authors.affiliation: Departments of Pathology, Virginia Commonwealth University, Richmond, VA ksanford@mcvh-vcu.edu.
authors.forename: Kimberly Williams
authors.initials: KW
authors.lastname: Sanford
authors.affiliation: Schools of Medicine, Virginia Commonwealth University, Richmond, VA.
authors.forename: Seda
authors.initials: S
authors.lastname: Bourikian
authors.affiliation: Forensic Biology, Virginia Commonwealth University, Richmond, VA.
authors.forename: Aryn
authors.initials: A
authors.lastname: McClain
authors.affiliation: Schools of Medicine, Virginia Commonwealth University, Richmond, VA.
authors.forename: Kyle
authors.initials: K
authors.lastname: Curtis
mesh_terms: D000906:Antibodies / Q000378:metabolism*; D001706:Biopsy; D006084:Graft Rejection; D006801:Humans; D007667:Kidd Blood-Group System / Q000276:immunology*; D007674:Kidney Diseases / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
chemical_list: D000906:Antibodies; D007667:Kidd Blood-Group System
keywords: Kidd antibodies; alloimmunization; antibody-mediated rejection; minor histocompatibility antigens; renal transplant; renal tubular epithelium