title: Systemic oxidant/antioxidant balance in human abdominal aortic aneurysm.
abstract: The aim of this study was to evaluate the oxidant-antioxidant balance in patients with abdominal aortic aneurysms (AAA). Forty-two consecutive patients with AAA and 46 control subjects were included. Total oxidant status (TOS) and total antioxidant status (TAS) levels were measured and the oxidative stress index (OSI) value determined. Serum TOS and OSI values in patients with AAA were higher than those in the controls (p < 0.001, p < 0.001, respectively). There was a positive correlation between abdominal aortic diameters, serum TOS levels (r = 0.592, p < 0.001) and OSI values (r = 0.598, p < 0.001). A cut-off value of 17.68 µmol H₂O₂equivalent/L for TOS was associated with 86% sensitivity and 83% specificity and a cut-off value of 1.77 for OSI was associated with 86% sensitivity and 81% specificity for predicting AAA. Systemic oxidative imbalance develops in patients with AAA, particularly as a result of an increase in TOS.
authors.affiliation: Department of Cardiovascular Surgery, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Menteşe
authors.affiliation: Department of Genetic and Bioengineering, Gümüşhane University, Faculty of Engineering and Natural Sciences, Gümüşhane, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Turan
authors.affiliation: Department of Cardiovascular Surgery, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey.
authors.forename: Sefer
authors.initials: S
authors.lastname: Usta
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Demir
authors.affiliation: Department of Cardiovascular Surgery, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Koral
authors.affiliation: Department of Emergency Medicine, Kanuni Teaching and Research Hospital, Trabzon, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Öztaş Menteşe
authors.affiliation: Department of Radiology, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey.
authors.forename: Ismail Gökhan
authors.initials: IG
authors.lastname: Çavuşoğlu
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Süleyman Caner
authors.initials: SC
authors.lastname: Karahan
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.affiliation: Department of Cardiovascular Surgery, Sakarya University, Faculty of Medicine, Sakarya, Turkey.
authors.forename: Orhan Veli
authors.initials: OV
authors.lastname: Doğan
authors.affiliation: Department of Cardiology, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey ahmetaykan@yahoo.com.
authors.forename: Ahmet Çağrı
authors.initials: AÇ
authors.lastname: Aykan
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D016877:Oxidants
keywords: abdominal aortic aneurysm; cardiovascular; oxidative stress; total antioxidant status; total oxidant status