title: Evaluation of psychiatric and genetic risk factors among primary relatives of suicide completers in Delhi NCR region, India.
abstract: Suicide as a public health problem is studied worldwide and association of psychiatric and genetic risk factors for suicidal behavior are the point of discussion in studies across different ethnic groups. The present study is aimed at evaluating psychiatric and genetic traits among primary relatives of suicide completer families in an urban Indian population. Bi-variate analysis shows significant increase in major depression (PHQ and Hamilton), stress, panic disorder, somatoform disorder and suicide attemptamong primary compared to other relatives. Sib pair correlations also reveal significant results for major depression (Hamilton), stress, suicide attempt, intensity of suicide ideation and other anxiety syndrome. 5-HTTLPR, 5-HTT (Stin2) and COMT risk alleles are higher among primary relatives, though statistically insignificant. Backward conditional logistic regression analysis show only independent variable, Depression (Hamilton) made a unique statistically significant contribution to the model in primary relatives.
authors.affiliation: Department of Anthropology, University of Delhi, Delhi, India.
authors.forename: Shivani
authors.initials: S
authors.lastname: Pasi
authors.affiliation: Department of Anthropology, University of Delhi, Delhi, India.
authors.forename: Piyoosh Kumar
authors.initials: PK
authors.lastname: Singh
authors.affiliation: Department of Pediatric Surgery A.I.I.M.S, Delhi, India.
authors.forename: Rajeev Kumar
authors.initials: RK
authors.lastname: Pandey
authors.affiliation: Department of Forensic Medicine, Moulana Azad Medical College, Delhi, India; Department of Forensic Medicine and Toxicology, Jamia Hamdard Institute of Medical Sciences & Research, New Delhi, India.
authors.forename: P C
authors.initials: PC
authors.lastname: Dikshit
authors.affiliation: Department of Psychiatry, G.B. Pant Hospital, Delhi, India.
authors.forename: R C
authors.initials: RC
authors.lastname: Jiloha
authors.affiliation: Department of Anthropology, University of Delhi, Delhi, India. Electronic address: profraoanthro@gmail.com.
authors.forename: V R
authors.initials: VR
authors.lastname: Rao
mesh_terms: D000328:Adult; D001007:Anxiety / Q000235:genetics / Q000523:psychology; D003863:Depression / Q000235:genetics / Q000523:psychology; D003865:Major Depressive Disorder / Q000235:genetics / Q000523:psychology; D005190:Family / Q000523:psychology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000523:psychology*; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D001523:Mental Disorders / Q000235:genetics* / Q000523:psychology; D012307:Risk Factors; D013001:Somatoform Disorders / Q000235:genetics / Q000523:psychology; D013405:Suicide / Q000523:psychology*; D014505:Urban Population; D044465:White People / Q000235:genetics / Q000523:psychology*
keywords: Depression; Family; Stress; Suicide