title: Antioxidant and Antiproliferative Activities of the Essential Oils from Thymbra capitata and Thymus Species Grown in Portugal.
abstract: The antioxidant and antiproliferative activities of the essential oils from Thymbra capitata and Thymus species grown in Portugal were evaluated. Thymbra and Thymus essential oils were grouped into two clusters: Cluster I in which carvacrol, thymol, p-cymene, α-terpineol, and γ-terpinene dominated and Cluster II in which thymol and carvacrol were absent and the main constituent was linalool. The ability for scavenging ABTS(•+) and peroxyl free radicals as well as for preventing the growth of THP-1 leukemia cells was better in essential oils with the highest contents of thymol and carvacrol. These results show the importance of these two terpene-phenolic compounds as antioxidants and cytotoxic agents against THP-1 cells.
authors.affiliation: Departamento de Química e Farmácia, Faculdade de Ciências e Tecnologia, Universidade do Algarve, MeditBio, Campus de Gambelas, 8005-139 Faro, Portugal.
authors.forename: Maria Graça
authors.initials: MG
authors.lastname: Miguel
authors.affiliation: Departamento de Química e Farmácia, Faculdade de Ciências e Tecnologia, Universidade do Algarve, MeditBio, Campus de Gambelas, 8005-139 Faro, Portugal.
authors.forename: Custódia
authors.initials: C
authors.lastname: Gago
authors.affiliation: Departamento de Química e Farmácia, Faculdade de Ciências e Tecnologia, Universidade do Algarve, MeditBio, Campus de Gambelas, 8005-139 Faro, Portugal.
authors.forename: Maria Dulce
authors.initials: MD
authors.lastname: Antunes
authors.affiliation: Instituto de la Grasa (C.S.I.C.), Universidad Pablo de Olavide, Edificio 46, Carretera de Utrera, km 1, 41013 Sevilla, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Megías
authors.affiliation: Instituto de la Grasa (C.S.I.C.), Universidad Pablo de Olavide, Edificio 46, Carretera de Utrera, km 1, 41013 Sevilla, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Cortés-Giraldo
authors.affiliation: Instituto de la Grasa (C.S.I.C.), Universidad Pablo de Olavide, Edificio 46, Carretera de Utrera, km 1, 41013 Sevilla, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Vioque
authors.affiliation: Centro de Estudos do Ambiente e do Mar Lisboa, Faculdade de Ciências, Universidade de Lisboa, CBV, DBV, 1749-016 Lisboa, Portugal ; Instituto Politécnico de Bragança, Escola Superior Agrária, Centro de Investigação de Montanha, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal.
authors.forename: A Sofia
authors.initials: AS
authors.lastname: Lima
authors.affiliation: Centro de Estudos do Ambiente e do Mar Lisboa, Faculdade de Ciências, Universidade de Lisboa, CBV, DBV, 1749-016 Lisboa, Portugal.
authors.forename: A Cristina
authors.initials: AC
authors.lastname: Figueiredo