title: Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts.
abstract: Ginsenoside Ro (Ro), an oleanolic acid-type ginsenoside, exhibited suppressive activities on reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) elevation in UV-B-irradiated fibroblasts. Ro could overcome the reduction of the total glutathione (GSH) contents in UV-B-irradiated fibroblasts. Ro could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Collectively, Ro possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts.
authors.affiliation: a Department of Biological Sciences , Kangwon National University , Chuncheon , Republic of Korea.
authors.forename: Hyun Ji
authors.initials: HJ
authors.lastname: Kang
authors.affiliation: a Department of Biological Sciences , Kangwon National University , Chuncheon , Republic of Korea.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Oh
authors.affiliation: b Department of Biochemistry , Kangwon National University , Chuncheon , Republic of Korea.
authors.forename: Sihyeong
authors.initials: S
authors.lastname: Lee
authors.affiliation: a Department of Biological Sciences , Kangwon National University , Chuncheon , Republic of Korea.
authors.forename: In Wang
authors.initials: IW
authors.lastname: Ryu
authors.affiliation: a Department of Biological Sciences , Kangwon National University , Chuncheon , Republic of Korea.
authors.forename: Kyunghoon
authors.initials: K
authors.lastname: Kim
authors.affiliation: b Department of Biochemistry , Kangwon National University , Chuncheon , Republic of Korea.
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Lim
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D036145:Ginsenosides / Q000494:pharmacology*; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000166:cytology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000975:Antioxidants; D036145:Ginsenosides; D017382:Reactive Oxygen Species; C064378:ginsenoside Ro; D020778:Matrix Metalloproteinase 2
keywords: UV-B radiation; ginsenoside Ro; glutathione; oxidative stress; reactive oxygen species