title: Whole breast and excision cavity radiotherapy plan comparison: Conformal radiotherapy with sequential boost versus intensity-modulated radiation therapy with a simultaneously integrated boost.
abstract: BACKGROUND
  A comparative study was conducted comparing the difference between (1) conformal radiotherapy (CRT) to the whole breast with sequential boost excision cavity plans and (2) intensity-modulated radiation therapy (IMRT) to the whole breast with simultaneously integrated boost to the excision cavity. The computed tomography (CT) data sets of 25 breast cancer patients were used and the results analysed to determine if either planning method produced superior plans.
  
  
  METHODS
  CT data sets from 25 past breast cancer patients were planned using (1) CRT prescribed to 50 Gy in 25 fractions (Fx) to the whole-breast planning target volume (PTV) and 10 Gy in 5Fx to the excision cavity and (2) IMRT prescribed to 60 Gy in 25Fx, with 60 Gy delivered to the excision cavity PTV and 50 Gy delivered to the whole-breast PTV, treated simultaneously. In total, 50 plans were created, with each plan evaluated by PTV coverage using conformity indices, plan maximum dose, lung dose, and heart maximum dose for patients with left-side lesions.
  
  
  RESULTS
  CRT plans delivered the lowest plan maximum doses in 56% of cases (average CRT = 6314.34 cGy, IMRT = 6371.52 cGy). They also delivered the lowest mean lung dose in 68% of cases (average CRT = 1206.64 cGy, IMRT = 1288.37 cGy) and V20 in 88% of cases (average CRT = 20.03%, IMRT = 21.73%) and V30 doses in 92% of cases (average CRT = 16.82%, IMRT = 17.97%). IMRT created more conformal plans, using both conformity index and conformation number, in every instance, and lower heart maximum doses in 78.6% of cases (average CRT = 5295.26 cGy, IMRT = 5209.87 cGy).
  
  
  CONCLUSIONS
  IMRT plans produced superior dose conformity and shorter treatment duration, but a slightly higher planning maximum and increased lung doses. IMRT plans are also faster to treat on a daily basis, with shorter fractionation.
authors.affiliation: Nepean Cancer Care Centre Penrith, New South Wales 2750, Australia.
authors.forename: Katherine
authors.initials: K
authors.lastname: Small
authors.affiliation: Nepean Cancer Care Centre Penrith, New South Wales 2750, Australia ; The Crown Princess Mary Cancer Centre Westmead, New South Wales 2145, Australia.
authors.forename: Chris
authors.initials: C
authors.lastname: Kelly
authors.affiliation: Nepean Cancer Care Centre Penrith, New South Wales 2750, Australia ; The Crown Princess Mary Cancer Centre Westmead, New South Wales 2145, Australia.
authors.forename: Rachael
authors.initials: R
authors.lastname: Beldham-Collins
authors.affiliation: NHMRC Clinical Trials Centre, University of Sydney Sydney, New South Wales 2050, Australia.
authors.forename: Val
authors.initials: V
authors.lastname: Gebski
keywords: Breast cancer; conformal radiotherapy; intensity-modulated radiotherapy (IMRT); lung dose; radiation therapy