title: A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery.
abstract: Polymeric nanoparticles have been widely used as nano-drug delivery systems in preclinical and clinical trials for cancer therapy, and these systems usually need to be sterically stabilized by poly(ethylene glycol) (PEG) to maintain stability and avoid rapid clearance by the immune system. Recently, zwitterionic materials have been demonstrated to be potential alternatives to the classic PEG. Herein, we developed two drug delivery systems stabilized by zwitterionic polyphosphoesters. These nanoparticles showed favourable stability and anti-protein absorption ability in vitro. Meanwhile, as drug carriers, these zwitterionic polyphosphoester-stabilized nanoparticles significantly prolonged drug circulation half-lives and increased drug accumulation in tumors, which was comparable to PEG-stabilized nanoparticles. Systemic delivery of doxorubicin (DOX) by zwitterionic polyphosphoester-stabilized nanoparticles significantly inhibited tumor growth in a MDA-MB-231 tumor model, suggesting the potential of zwitterionic polyphosphoester-based nanoparticles in anticancer drug delivery.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, Anhui, China. jwang699@ustc.edu.cn yangxz@mail.ustc.edu.cn.
authors.forename: Rong
authors.initials: R
authors.lastname: Sun
authors.forename: Xiao-Jiao
authors.initials: XJ
authors.lastname: Du
authors.forename: Chun-Yang
authors.initials: CY
authors.lastname: Sun
authors.forename: Song
authors.initials: S
authors.lastname: Shen
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Xian-Zhu
authors.initials: XZ
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Bao
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D026921:Amino Acid Transport Systems, Neutral / Q000737:chemistry* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use*; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D026921:Amino Acid Transport Systems, Neutral; D004337:Drug Carriers; D011108:Polymers; D011092:Polyethylene Glycols; D004317:Doxorubicin