title: [Plasma IL-18 levels are related to insulin and are modulated by IL-18 gene polymorphisms].
abstract: BACKGROUND
  Atherosclerosis is an inflammatory chronic disease influenced by multiple factors. Different prospective studies have shown that plasmatic levels of inflammatory markers were related to atherosclerosis and cardiovascular disease.
  
  
  OBJECTIVE
  To evaluate whether plasmatic levels of interleukin 18 (IL-18) are modulated by SNPs (single nucleotide polymorphisms) of the IL 18 gene and its possible association with insulin levels and other cardiovascular risk factors.
  
  
  METHODS
  746 individuals were studied for a period of two years by opportunistic selection in the metropolitan area of Valencia. Parameters of lipid and glucose metabolism were analyzed by standard methodology. IL-18 was measured by ELISA.
  
  
  RESULTS
  Individuals with insulin resistance showed significant higher levels of IL-18. IL 18 was significantly correlated with insulin levels and other cardiovascular risk factors. The CC genotype of the rs1834481 SNP was significantly associated with lower levels of IL-18. However, the GG genotype of the rs7559479 was associated with significant higher levels of IL-18.
  
  
  CONCLUSIONS
  IL-18 is associated with insulin resistance and other cardiovascular risk factors, being those levels genetically regulated.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valencia, INCLIVA, Valencia, España; Departamento de Medicina, Universidad de Valencia, Valencia, España; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, España. Electronic address: Sergio.Martinez@uv.es.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martinez-Hervas
authors.affiliation: Unidad de Genotipado y Diagnóstico Genético, INCLIVA, Valencia, España.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Martínez-Barquero
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valencia, INCLIVA, Valencia, España.
authors.forename: Ester
authors.initials: E
authors.lastname: Nuñez Savall
authors.affiliation: Unidad de Genotipado y Diagnóstico Genético, INCLIVA, Valencia, España.
authors.forename: Verónica
authors.initials: V
authors.lastname: Lendínez
authors.affiliation: Unidad de Genotipado y Diagnóstico Genético, INCLIVA, Valencia, España.
authors.forename: Laura
authors.initials: L
authors.lastname: Olivares
authors.affiliation: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, España.
authors.forename: Esther
authors.initials: E
authors.lastname: Benito
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valencia, INCLIVA, Valencia, España; Departamento de Medicina, Universidad de Valencia, Valencia, España; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, España.
authors.forename: Jose T
authors.initials: JT
authors.lastname: Real
authors.affiliation: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, España; Unidad de Genotipado y Diagnóstico Genético, INCLIVA, Valencia, España.
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Chaves
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valencia, INCLIVA, Valencia, España; Departamento de Medicina, Universidad de Valencia, Valencia, España; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, España.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Ascaso
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000235:genetics*; D020382:Interleukin-18 / Q000097:blood / Q000235:genetics*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007328:Insulin; D020382:Interleukin-18; D005947:Glucose
keywords: IL-18; Insulin resistance; Resistencia a la insulina; SNP