title: [Outcome of rapidly progressive glomerulonephritis post-streptococcal disease in children].
abstract: BACKGROUND
  Rapidly progressive glomerulonephritis is a rare form of postinfectious glomerulonephritis. The aim of this study was to describe the outcome of our patients with severe post-streptococcal glomerulonephritis.
  
  
  METHODS
  This retrospective study was conducted in the department of pediatrics in Charles-Nicolle Hospital during a period of 13 years (1997-2009).
  
  
  RESULTS
  Twenty-seven children were identified. The mean age was 8.7 years. All patients presented renal failure at presentation. The mean serum creatinine at presentation was 376.9 μmol/L. Six patients presented nephrotic syndrome. Twenty-six children had renal biopsies. Renal biopsies showed crescents in 24 cases. Eighteen children received pulse dose of corticosteroids (66.6%) and 6 children (22%) received pulse dose of corticosteroids and cyclophosphamide. Eleven patients required dialysis. At last follow-up, 22 patients (81.5%) had normal kidney function, 2 had renal dysfunction and 3 reached end stage renal disease. The only significant determinant for renal survival was the supportive dialysis (P=0.015).
  
  
  CONCLUSIONS
  Rapidly progressive glomerulonephritis is uncommon. There have been significant advancements in supportive, as well as specific therapy, but the outcome continues to be poor.
authors.affiliation: Service de pédiatrie, hôpital Charles-Nicolle, 2037 Tunis, Tunisie. Electronic address: maneljellouli@yahoo.fr.
authors.forename: Manel
authors.initials: M
authors.lastname: Jellouli
authors.affiliation: Service de pédiatrie, hôpital Charles-Nicolle, 2037 Tunis, Tunisie.
authors.forename: Sondos
authors.initials: S
authors.lastname: Maghraoui
authors.affiliation: Service de pédiatrie, hôpital Charles-Nicolle, 2037 Tunis, Tunisie.
authors.forename: Kamel
authors.initials: K
authors.lastname: Abidi
authors.affiliation: Service de pédiatrie, hôpital Charles-Nicolle, 2037 Tunis, Tunisie.
authors.forename: Yosra
authors.initials: Y
authors.lastname: Hammi
authors.affiliation: Service de médecine interne, hôpital Charles-Nicolle, Tunis, Tunisie.
authors.forename: Rim
authors.initials: R
authors.lastname: Goucha
authors.affiliation: Service de pédiatrie, hôpital Charles-Nicolle, 2037 Tunis, Tunisie.
authors.forename: Ouns
authors.initials: O
authors.lastname: Naija
authors.affiliation: Service de pédiatrie, hôpital Charles-Nicolle, 2037 Tunis, Tunisie.
authors.forename: Chokri
authors.initials: C
authors.lastname: Zarrouk
authors.affiliation: Service de pédiatrie, hôpital Charles-Nicolle, 2037 Tunis, Tunisie.
authors.forename: Tahar
authors.initials: T
authors.lastname: Gargah
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007668:Kidney / Q000473:pathology*; D008297:Male; D011379:Prognosis; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000209:etiology / Q000628:therapy; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide
keywords: Biopsie rénale; Children; Enfant; Glomérulonéphrite aiguë; Infection streptococcique; Insuffisance rénale; Postinfectious glomerulonephritis; Renal biopsy; Renal failure