title: Use of miRNAs as biomarkers in sepsis.
abstract: Sepsis is one of the most common causes of death in critical patients. Severe generalized inflammation, infections, and severe physiological imbalances significantly decrease the survival rate with more than 50%. Moreover, monitoring, evaluation, and therapy management often become extremely difficult for the clinician in this type of patients. Current methods of diagnosing sepsis vary based especially on the determination of biochemical-humoral markers, such as cytokines, components of the complement, and proinflammatory and anti-inflammatory compounds. Recent studies highlight the use of new biomarkers for sepsis, namely, miRNAs. miRNAs belong to a class of small, noncoding RNAs with an approximate content of 19-23 nucleotides. Following biochemical and physiological imbalances, the expression of miRNAs in blood or other body fluids changes significantly. Moreover, its stability, specificity, and selectivity make miRNAs ideal candidates for sepsis biomarkers. In conclusion, we can affirm that stable species of circulating miRNAs represent potential biomarkers for monitoring the evolution of sepsis.
authors.affiliation: Department of Forensic Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Raluca
authors.initials: R
authors.lastname: Dumache
authors.affiliation: Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania ; Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania ; Faculty of Chemistry, Biology, and Geography, West University of Timisoara, 300115 Timisoara, Romania.
authors.forename: Alexandru Florin
authors.initials: AF
authors.lastname: Rogobete
authors.affiliation: Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania ; Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Ovidiu Horea
authors.initials: OH
authors.lastname: Bedreag
authors.affiliation: Clinic of Anaesthesia and Intensive Care "Casa Austria", Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania.
authors.forename: Mirela
authors.initials: M
authors.lastname: Sarandan
authors.affiliation: Clinic of Anaesthesia and Intensive Care "Casa Austria", Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania.
authors.forename: Alina Carmen
authors.initials: AC
authors.lastname: Cradigati
authors.affiliation: Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania ; Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Papurica
authors.affiliation: Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania.
authors.forename: Corina Maria
authors.initials: CM
authors.lastname: Dumbuleu
authors.affiliation: Faculty of Chemistry, Biology, and Geography, West University of Timisoara, 300115 Timisoara, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Nartita
authors.affiliation: Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania ; Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Dorel
authors.initials: D
authors.lastname: Sandesc
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018805:Sepsis / Q000175:diagnosis / Q000235:genetics*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs