title: Tissue engineered vascular grafts: Origins, development, and current strategies for clinical application.
abstract: Since the development of a dependable and durable synthetic non-autogenous vascular conduit in the mid-twentieth century, the field of vascular surgery has experienced tremendous growth. Concomitant with this growth, development in the field of bioengineering and the development of different tissue engineering techniques have expanded the armamentarium of the surgeon for treating a variety of complex cardiovascular diseases. The recent development of completely tissue engineered vascular conduits that can be implanted for clinical application is a particularly exciting development in this field. With the rapid advances in the field of tissue engineering, the great hope of the surgeon remains that this conduit will function like a true blood vessel with an intact endothelial layer, with the ability to respond to endogenous vasoactive compounds. Eventually, these engineered tissues may have the potential to supplant older organic but not truly biologic technologies, which are used currently.
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address: ehsan.benrashid@dm.duke.edu.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Benrashid
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address: christopher.mccoy@dm.duke.edu.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: McCoy
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address: linda.youngwirth@dm.duke.edu.
authors.forename: Linda M
authors.initials: LM
authors.lastname: Youngwirth
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address: jina.kim1@dm.duke.edu.
authors.forename: Jina
authors.initials: J
authors.lastname: Kim
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address: roberto.manson@dm.duke.edu.
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Manson
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address: jim.otto@dm.duke.edu.
authors.forename: James C
authors.initials: JC
authors.lastname: Otto
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address: jeffrey.lawson@dm.duke.edu.
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Lawson
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D002318:Cardiovascular Diseases / Q000601:surgery*; D006801:Humans; D023822:Tissue Engineering
keywords: Bioengineering; Blood vessel; Tissue engineered vascular graft; Tissue engineering; Vascular conduit; Vascular graft