title: Analysis of the treatment of gliomas with SEC therapy combined with radiochemotherapy.
abstract: OBJECTIVE
  To investigate the anti-glioma effects of staphylococcal enterotoxin C (SEC) combined with surgery, radiotherapy and chemotherapy, and the IL-2 of lymphocytes activated by SEC.
  
  
  METHODS
  A total of 92 patients with gliomas which had been surgically removed, were randomly divided into a control, and treatment groups A (systemic application of SEC) and B (local application of lymphocytes activated by SEC). The treatment effects were observed on a CT scan of the head. The SEC's induction on the IL-2 secretion by lymphocytes was determined using immunohistochemistry and RT-PCR methods.
  
  
  RESULTS
  Clinical materials showed that the effective rate (CR and PR) in the control group was 32.0%. In the treatment group A, the effective rate was 51.6% and 63.6% in the group B. The IL-2 of lymphocytes secreting activity activated by SEC began to secrete IL-2 on the 1st day and reached a peak during the 3rd day and the 5th day.
  
  
  CONCLUSIONS
  As a superantigen, SEC combined with surgery, radiotherapy and chemotherapy can improve treatment. The lymphocytes activated by SEC can release IL-2.
authors.affiliation: Department of Brain Tumor Research, No. 2 Hospital of Suzhou University, Suzhou, China. wangfan1965@sina.com.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Huang
authors.forename: L-Y
authors.initials: LY
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D004768:Enterotoxins / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018089:Superantigens / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004768:Enterotoxins; D018089:Superantigens; C034959:enterotoxin C, staphylococcal