title: Inverse Correlation between Serum C-Reactive Protein and Magnesium Levels in Smokers and Nonsmokers.
abstract: BACKGROUND
  Smoking plays a key role in increasing the inflammatory marker C-reactive protein (CRP).
  
  
  OBJECTIVE
  To examine inverse correlation between CRP and magnesium levels in smokers and nonsmokers.
  
  
  METHODS
  A total of 192 healthy adult male subjects were included in the present study, out of which 96 were smokers and the remaining 96 were nonsmokers having age range from 20 to 40 years, and all the subjects belonged to District Matyari of Hyderabad. Serum CRP was measured by NycoCard standard kit method and magnesium levels by DiaSys standard kit method in smokers and nonsmokers.
  
  
  RESULTS
  The levels of serum CRP in smokers (14.62 ± 0.16 mg/L) is high as compared to nonsmokers (4.81 ± 0.38 mg/L), which is highly significant (P < 0.001). However, inverse results were seen for serum magnesium levels which were significantly higher (P < 0.001) in nonsmokers (2.52 ± 0.18 mg/L) as compared to the smokers (1.09 ± 0.38 mg/dL). A significant (P < 0.001) inverse relationship between serum CRP and magnesium concentrations were seen in smokers.
  
  
  CONCLUSIONS
  This result shows that smoking increases serum CRP, an inflammatory marker parallel to decrease in serum magnesium levels in smokers having 20-40 years of age.
authors.affiliation: Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Muhamamd Atif
authors.initials: MA
authors.lastname: Ata
authors.affiliation: Department of Biochemistry, Isra University, Hyderabad, Pakistan.
authors.forename: Shumaila Shabbir
authors.initials: SS
authors.lastname: Shaikh
authors.affiliation: Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Tehseen
authors.initials: T
authors.lastname: Iqbal
authors.affiliation: Muhammadi Hospital, Latifabad, Hyderabad, Sindh, Pakistan.
authors.lastname: Hina
authors.affiliation: Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Daniyal
authors.initials: D
authors.lastname: Jamil
authors.affiliation: Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Rabiya
authors.initials: R
authors.lastname: Khan
authors.affiliation: Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Masharib Basheer
authors.initials: MB
authors.lastname: Qazi
authors.affiliation: Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Telil
authors.initials: T
authors.lastname: Riwan
keywords: C-reactive protein; Magnesium; Smoking