title: Antiglycation activity of lipophilized epigallocatechin gallate (EGCG) derivatives.
abstract: Lipophilized EGCG derivatives were synthesized by esterification of EGCG with aliphatic fatty acids and demonstrated to possess many advantages, such as higher lipophilicity and apparent health benefits over the parent EGCG. This study used a total of seven lipophilized EGCG derivatives with fatty acids of different chain lengths attached and examined the impact of lipophilization on EGCG's antiglycation activity in vitro. The length of fatty acid chain was found to be an important factor, which positively correlated with ABTS radical scavenging capacity but long chain bulky substitutes prevented methylglyoxal (MGO) trapping. Except docosahexaenoic acid (DHA), lipophilization generally showed no interference with EGCG's in vitro inhibitory activity of advanced glycation endproducts (AGEs) formation. Therefore, the lipophilized EGCG derivatives are promising candidates worthy of further exploration for preventing AGEs accumulation in vivo and hence treating AGEs-associated diseases.
authors.affiliation: College of Food Science and Technology, Shanghai Ocean University, Shanghai, PR China.
authors.forename: Mingfu
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Xinchen
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.
authors.forename: Ying Joy
authors.initials: YJ
authors.lastname: Zhong
authors.affiliation: Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.
authors.forename: Nishani
authors.initials: N
authors.lastname: Perera
authors.affiliation: Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada. Electronic address: fshahidi@mun.ca.
authors.forename: Fereidoon
authors.initials: F
authors.lastname: Shahidi
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005612:Freeze Drying; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D011765:Pyruvaldehyde / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D017127:Glycation End Products, Advanced; D011765:Pyruvaldehyde; D002392:Catechin; C045651:epigallocatechin gallate
keywords: AGEs inhibition; Antioxidant activity; Lipophilized EGCG; MGO trapping