title: Glioblastoma multiforme in the very elderly.
abstract: Glioblastoma is the most malignant and most common primary brain tumour and is treated with resection followed by post-operative radiotherapy and chemotherapy. However, a significant amount of patients are older than 80 years, and such an approach may not be appropriate. Data on patients aged 80 or older with glioblastoma from two hospitals was collected using the CNS Tumour Database on the Australian Comprehensive Cancer Outcomes and Research Database (ACCORD) system operated by BioGrid. Between 2008 and July 2011, 40 patients aged 80 years or older were diagnosed with glioblastoma. The median ECOG PS was 2 and the ASA score was 3. All 40 patients underwent surgery and 33% had a gross total resection. Only six patients (15%) had either post-operative radiotherapy or chemotherapy. The overall median survival was 4 months (range 0-18 months) and 28% of patients lived between 6 and 24 months. This is the largest reported cohort of very elderly patients with glioblastoma. Patients tolerated surgery but few went on to receive post-operative radiotherapy or chemotherapy. This patient population requires special attention and in particular would benefit from participation in suitable clinical trials to determine the best care regime.
authors.affiliation: Department of Neurosurgery, University of Melbourne, Parkville, Melbourne, Victoria, Australia. fvconnon@gmail.com.
authors.forename: Felicity V
authors.initials: FV
authors.lastname: Connon
authors.affiliation: Department Medical Oncology, Royal Melbourne Hospital, University of Melbourne, Parkville, Melbourne, Victoria, Australia, 3050. mark.rosenthal@mh.org.au.|Department of Medicine, University of Melbourne, Parkville, Melbourne, Victoria, Australia. mark.rosenthal@mh.org.au.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rosenthal
authors.affiliation: Department of Neurosurgery, University of Melbourne, Parkville, Melbourne, Victoria, Australia. kate.drummond@mh.org.au.|Department of Surgery, University of Melbourne, Parkville, Melbourne, Victoria, Australia, 3050. kate.drummond@mh.org.au.
authors.forename: Katherine
authors.initials: K
authors.lastname: Drummond
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over / Q000706:statistics & numerical data*; D001315:Australia / Q000453:epidemiology; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000601:surgery; D015331:Cohort Studies; D003131:Combined Modality Therapy; D016208:Databases, Factual; D005260:Female; D005909:Glioblastoma / Q000453:epidemiology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: Elderly; Glioblastoma; Glioma; Treatment