title: [Immunomonitoring for cytomegalovirus infection in kidney transplantation: Development and prospects].
abstract: Cytomegalovirus infection in kidney transplantation is associated with increased morbidity and mortality through direct and indirect effects. International guidelines had been recently updated, focusing on diagnostic, prevention strategies and curative treatment. Cytomegalovirus-specific immune response plays also an important function in controlling the virus. Here, we propose to present the different components of this specific immune response and the advantages of immune monitoring for patient's management: identification of patients who require a treatment, adaptation of curative treatment length, guidance for resistance genotypic testing.
authors.affiliation: Service de néphrologie-transplantation-dialyse, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux, France.
authors.forename: Hannah
authors.initials: H
authors.lastname: Kaminski
authors.affiliation: Service de néphrologie-transplantation-dialyse, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux, France; Unité mixte de recherche (UMR) 5164, centre national de la recherche scientifique (CNRS), 146, rue Léo-Saignat, 33076 Bordeaux, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Couzi
authors.affiliation: Unité mixte de recherche (UMR) 5164, centre national de la recherche scientifique (CNRS), 146, rue Léo-Saignat, 33076 Bordeaux, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Déchanet-Merville
authors.affiliation: Service de néphrologie-transplantation-dialyse, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux, France; Unité mixte de recherche (UMR) 5164, centre national de la recherche scientifique (CNRS), 146, rue Léo-Saignat, 33076 Bordeaux, France. Electronic address: pierre.merville@chu-bordeaux.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Merville
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D015166:Monitoring, Immunologic / Q000379:methods*; D012307:Risk Factors
chemical_list: D000998:Antiviral Agents
keywords: Cytomegalovirus infection; Immune monitoring; Infection à cytomégalovirus; Kidney transplantation; Surveillance immunologique; Transplantation rénale