title: Effects of intermittent exercise on biomarkers of cardiovascular risk in night shift workers.
abstract: OBJECTIVE
  Cathepsin L (CatL), cathepsin S (CatS), and arteriosclerosis adhesion molecules such as monocyte chemotactic protein-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble E-selectin (sE-selectin) are potent elastases implicated in human arterial wall remodeling. In this study, we aimed to evaluate the effects of intermittent exercise on the plasma concentrations of these cathepsins and arteriosclerosis adhesion molecules in night shift workers.
  
  
  METHODS
  Thirty male participants who were night shift workers (experimental group, n = 15; control group, n = 15) were included in this study. The experimental group performed an intermittent exercise at 10-min bouts (30 min per day), three days a week during 10 weeks. Body composition, blood pressure, and cardiovascular disease risk factors were measured.
  
  
  RESULTS
  After intermittent exercise, significant group time interactions for body weight (p < .01) and body fat percentage (p < .01) were found. With regard to cardiovascular disease risk factors, group time interactions for CatL (p < .01), CatS (p < .01), MCP-1 (p < .05), sE-selectin (p < .01), and sVCAM-1 (p < .01) were significant.
  
  
  CONCLUSIONS
  This study provides preliminary evidence to suggest that intermittent exercise may represent an effective intervention strategy for preventing atherosclerosis, thus leading to improved cardiovascular health in night shift workers.
authors.affiliation: College of Sport Science, Dong-A University, Busan, South Korea.
authors.forename: Seung-Taek
authors.initials: ST
authors.lastname: Lim
authors.affiliation: Department of Sport Science, Korea Institute of Sports Science, Seoul, South Korea. Electronic address: minseokki@kspo.or.kr.
authors.forename: Seok-Ki
authors.initials: SK
authors.lastname: Min
authors.affiliation: College of Sport Science, Dong-A University, Busan, South Korea.
authors.forename: Yoo-Chan
authors.initials: YC
authors.lastname: Kwon
authors.affiliation: College of Sport Science, Dong-A University, Busan, South Korea.
authors.forename: Sang-Kab
authors.initials: SK
authors.lastname: Park
authors.affiliation: Department of Health Care and Science, Dong-A University, Busan, South Korea; Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan; Institute of Convergence Bio-Health, Dong-A University, Busan, South Korea. Electronic address: htpark@dau.ac.kr.
authors.forename: Hyuntae
authors.initials: H
authors.lastname: Park
mesh_terms: D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001823:Body Composition; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D056668:Cathepsin L / Q000097:blood*; D002403:Cathepsins / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010561:Personnel Staffing and Scheduling; D065840:Protective Factors; D056910:Republic of Korea; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D002403:Cathepsins; C534281:CTSL protein, human; D056668:Cathepsin L; C028217:cathepsin S
keywords: Adhesion molecules; Cathepsin K; Cathepsin L; Cathepsin S; Intermittent exercise; Night shift worker