title: Is dynamometry able to infer the risk of muscle mass loss in patients with COPD?
abstract: BACKGROUND
  Sarcopenia is characterized by a progressive and generalized decrease of strength and muscle mass. Muscle mass loss is prevalent in patients with chronic obstructive pulmonary disease (COPD) as a result of both the disease and aging. Some methods have been proposed to assess body composition (and therefore identify muscle mass loss) in this population. Despite the high accuracy of some methods, they require sophisticated and costly equipment.
  
  
  OBJECTIVE
  The purpose of this study was to infer the occurrence of muscle mass loss measured by a sophisticated method (dual energy X-ray absorptiometry [DEXA]) using a more simple and affordable equipment (dynamometer).
  
  
  METHODS
  Fifty-seven stable subjects with COPD were evaluated for anthropometric characteristics, lung function, functional exercise capacity, body composition, and peripheral muscle strength. A binary logistic regression model verified whether knee-extension strength (measured by dynamometry) could infer muscle mass loss (from DEXA).
  
  
  RESULTS
  Patients with decreased knee-extension strength were 5.93 times more likely to have muscle mass loss, regardless of sex, disease stage, and functional exercise capacity (P=0.045).
  
  
  CONCLUSIONS
  Knee-extension dynamometry was able to infer muscle mass loss in patients with COPD.
authors.affiliation: Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil.
authors.forename: Dionei
authors.initials: D
authors.lastname: Ramos
authors.affiliation: Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil.
authors.forename: Giovana Navarro
authors.initials: GN
authors.lastname: Bertolini
authors.affiliation: Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil.
authors.forename: Marceli Rocha
authors.initials: MR
authors.lastname: Leite
authors.affiliation: Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil.
authors.forename: Luiz Carlos Soares
authors.initials: LC
authors.lastname: Carvalho Junior
authors.affiliation: Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil.
authors.forename: Paula Roberta
authors.initials: PR
authors.lastname: da Silva Pestana
authors.affiliation: Department of Motricity Sciences, São Paulo State University, Rio Claro, Brazil.
authors.forename: Vanessa Ribeiro
authors.initials: VR
authors.lastname: dos Santos
authors.affiliation: Department of Motricity Sciences, São Paulo State University, Rio Claro, Brazil.
authors.forename: Ana Claudia de Souza
authors.initials: AC
authors.lastname: Fortaleza
authors.affiliation: Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil.
authors.forename: Fernanda Maria Machado
authors.initials: FM
authors.lastname: Rodrigues
authors.affiliation: Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil.
authors.forename: Ercy Mara Cipulo
authors.initials: EM
authors.lastname: Ramos
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D001823:Body Composition; D005260:Female; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D053581:Muscle Strength Dynamometer; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016017:Odds Ratio; D009929:Organ Size; D010808:Physical Examination / Q000295:instrumentation*; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012307:Risk Factors; D055948:Sarcopenia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D013147:Spirometry
keywords: COPD; peripheral muscle strength; sarcopenia