title: Asymmetric Synthesis of α-Amino Ketones by Brønsted Acid Catalysis.
abstract: The highly efficient, regioselective, and enantioselective transfer hydrogenation of α-keto ketimines and reductive amination of diketones by Brønsted acid catalysis is described. A series of chiral α-amino ketones is prepared in high yields (up to >99%), excellent regioselectivities (up to >99:1), and enantioselectivities (up to 98% ee). This method has broad substrate scope.
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wen
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Peng
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Fu
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Qi-Xiang
authors.initials: QX
authors.lastname: Guo