title: Causes that influence the detachment rate after Descemet membrane endothelial keratoplasty.
abstract: OBJECTIVE
  To investigate Descemet graft (DG) detachment rate after Descemet membrane endothelial keratoplasty (DMEK) in relation to DG position.
  
  
  METHODS
  A total of 175 consecutive pseudophakic eyes that underwent DMEK (175 eyes for Fuchs endothelial dystrophy) from September 2009 through February 2014 at the Tübingen Eye Hospital DG position were studied retrospectively by surgical video at the end of an operation. A group of 45 eyes showed a decentration of the DG with a stromal gap of ≥1.5 mm over at least 3 clock hours between the descematorhexis edge and the DG. DG detachment was documented at a mean follow-up of 13.9 ± 3.7 months after surgery. DG detachment was defined as a detachment of 20 % or more of the DG surface area. Various donor characteristics and patient characteristics were analyzed.
  
  
  RESULTS
  The best spectacle-corrected visual acuity (BCVA) in the group of eyes with central well-positioned DG differed significantly from those of eyes with decentered DG. The preoperative BCVA in the central well-positioned DG group was 0.63 ± 0.40 logMAR, and in the decentered DG group 0.91 ± 0.51 logMAR (P < 0.001). The postoperative BCVA in the group of eyes with central well-positioned DG was 0.12 ± 0.11 logMAR, and in the group with decentered DG 0.23 ± 0.29 logMAR (P < 0.001). Endothelial cell density and patient characteristics such as age, gender, and intraocular pressure did not differ significantly between the two groups. The group of eyes with central well-positioned DG showed DG detachment in 12 %; the group with decentered DG findings had DG detachment in 87 % (P < 0.001) at the 12 month follow up.
  
  
  CONCLUSIONS
  The present findings demonstrate the importance of central well-positioned DG and the relation of disease severity. Central well-positioned DG may reduce the incidence of DG detachment. Overlapping of the donor DG and the host Descemet membrane seems to be responsible for DG detachment. One possible way to enhance graft adhesion could be a larger descematorhexis, which avoids an overlapping. The second possible way could be not waiting too long for surgery to reduce disease severity.
authors.affiliation: Centre for Ophthalmology, University of Tübingen, Tübingen, Germany. tobias.roeck@googlemail.com.
authors.forename: T
authors.initials: T
authors.lastname: Röck
authors.affiliation: Department of General Medicine, Ruhr-University Bochum, Bochum, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bramkamp
authors.affiliation: Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
authors.forename: K U
authors.initials: KU
authors.lastname: Bartz-Schmidt
authors.affiliation: Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Röck
authors.affiliation: Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Yörük
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D003886:Descemet Membrane / Q000473:pathology*; D057111:Descemet Stripping Endothelial Keratoplasty / Q000009:adverse effects*; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery*; D006084:Graft Rejection / Q000453:epidemiology / Q000209:etiology*; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014741:Video Recording; D014792:Visual Acuity
keywords: Centrally positioned Descemet graft; Descemet graft detachment; Descemet membrane endothelial keratoplasty (DMEK); Posterior lamellar keratoplasty; Recovery of corneal transparency