title: Pharmacological agents for nonalcoholic steatohepatitis.
abstract: The rationale for specific pharmacologic therapy in nonalcoholic steatohepatitis (NASH) is determined by the potential for disease progression and the difficulties, in many patients, to successfully implement diet and lifestyle changes in the long term. Because they correct insulin resistance, insulin-sensitizing agents are attractive candidates for the treatment of NASH. However, two randomized studies have shown that vitamin E, despite having no effect on insulin sensitivity, achieves interesting histological and biochemical efficacy. This review provides an insight into the therapeutic efficacy and safety issues of different pharmacological agents tested in human NASH.
authors.affiliation: Service d'Hépatologie et Gastro-entérologie, INSERM 1048 and Université Paul Sabatier, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. maeva.guillaume@inserm.fr.|Service d'Hépatologie et Gastro-entérologie, Hôpital Purpan, Pavillon Dieulafoy, 4ème étage, Place du Docteur Baylac, TSA 40031, 31059, Toulouse Cedex 9, France. maeva.guillaume@inserm.fr.
authors.forename: Maeva
authors.initials: M
authors.lastname: Guillaume
authors.affiliation: INSERM U938, Hospital Pitié Salpêtrière, CdR Saint-Antoine and Université Pierre et Marie Curie, Paris, France. vratziu@teaser.fr.|Service d'Hépatologie et Gastro-entérologie, Hôpital Pitié-Salpêtrière, 47-83, Boulevard de l'hôpital, 75651, Paris Cedex 13, France. vratziu@teaser.fr.
authors.forename: Vlad
authors.initials: V
authors.lastname: Ratziu
keywords: Fibrosis; Glitazones; Insulin resistance; Insulin sensitizers; Oxidative stress; Steatohepatitis; Steatosis; Ursodesoxycholic acid; Vitamin E