title: Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging.
abstract: Changes in nucleolar morphology and function are tightly associated with cellular activity, such as growth, proliferation, and cell cycle progression. Historically, these relationships have been extensively examined in cancer cells, which frequently exhibit large nucleoli and increased ribosome biogenesis. Recent findings indicate that alteration of nucleolar activity is a key regulator of development and aging. In this review, we have provided evidences that the nucleolus is not just a housekeeping factor but is actively involved in the regulation of cell proliferation, differentiation, and senescence both in vitro and in vivo. In addition, we have discussed how alteration of nucleolar function and nucleolar proteins induces specific physiological effects rather than widespread effects.
authors.affiliation: Stem Cell Engineering Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1, Higashi, Tsukuba, Ibaraki, 305-8562, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Takada
authors.affiliation: Stem Cell Engineering Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1, Higashi, Tsukuba, Ibaraki, 305-8562, Japan. akikuri@hotmail.com.
authors.forename: Akira
authors.initials: A
authors.lastname: Kurisaki
mesh_terms: D000375:Aging / Q000502:physiology*; D002454:Cell Differentiation; D002466:Cell Nucleolus / Q000502:physiology*; D049109:Cell Proliferation; D016922:Cellular Senescence; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism*; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology
chemical_list: D009687:Nuclear Proteins; D012269:Ribosomal Proteins
keywords: Differentiation; Longevity; Nucleolus; Ribosome biogenesis; Stem cells