title: [Copeptin - stable C-terminal fragment of pre-provasopressin as a new stress marker in newborns].
abstract: Stress stimuli, including diseases, disturb homeostasis of the body and enhance secretion of various hypothalamus, pituitary and adrenal gland hormones. One of the main hypothalamic hormones secreted in stress conditions is arginine vasopressin (AVP). Vasopressin concentration in the blood reflects the severity of disease and disorders of blood volume. Measurement of vasopressin is difficult and subjected to considerable laboratory error because of the short half-life in serum and its instability in withdrawn blood samples. This hormone and copeptin are peptides produced during the cleavage of a larger precursor polypeptide: pre-provasopressin. Both peptides are formed in equimolar amounts. Copeptin is a more stable peptide, measurement of which can be performed with higher accuracy. This paper presents the importance of copeptin as a marker of stress, with particular emphasis on the neonatal period, analyzing the impact of gestational age and the route of delivery. Its potential application for assessing the degree of hydration in the adaptation period is also discussed.
authors.affiliation: Oddział Noworodków Szpitala Zakonu OO. Bonifratrów w Katowicach.
authors.forename: Anna
authors.initials: A
authors.lastname: Jarosz-Lesz
authors.affiliation: Klinika Intensywnej Terapii i Patologii Noworodka GCZD SUM Katowice.
authors.forename: Iwona
authors.initials: I
authors.lastname: Maruniak-Chudek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001127:Arginine Vasopressin / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins; D001127:Arginine Vasopressin