title: Two new lignans from twigs of Aglaia odorata.
abstract: HPLC-guided separation of twigs of Aglaia odorata led to the isolation of eight lignans, including two new ones, 3'-methoxy-N-demethylrocaglamide (1) and 4'-O-demethyl-deacetylaglaxiflorin A (2). Compound 1 showed excellent cytotoxicity against three human cancer cell lines, HeLa, SGC-7901 gastric cancer, and A-549 lung cancer with the values of 0.32, 0.12, and 0.25 μM, respectively.
authors.affiliation: a College of Horticulture and Landscape, Yunnan Agriculture University , Kunming 650201 , China.|b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Peng
authors.affiliation: c Germplasm Bank of Wild Species in Southwest China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Wu-Xiang
authors.initials: WX
authors.lastname: Fu
authors.affiliation: c Germplasm Bank of Wild Species in Southwest China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Zeng
authors.affiliation: a College of Horticulture and Landscape, Yunnan Agriculture University , Kunming 650201 , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Mei-Fen
authors.initials: MF
authors.lastname: Bao
authors.affiliation: b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Xiang-Hai
authors.initials: XH
authors.lastname: Cai
mesh_terms: D031602:Aglaia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D013274:Stomach Neoplasms / Q000188:drug therapy
chemical_list: C000608889:3'-methoxy-N-demethylrocaglamide; C000608890:4'-O-demethyl-deacetylaglaxiflorin A; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D017705:Lignans
keywords: 3′-methoxy-N-demethylrocaglamide; 4′-O-demethyl-deacetylaglaxiflorin A; Aglaia odorata; Meliaceae; cytotoxicity