title: [Effects of Wine-processing on Rhei Radix et Rhizoma on Upper-energizer Disease and Effects on Activities of Energy Metabolism Enzymes in Liver].
abstract: OBJECTIVE
  To compare the effects of crude and wine-processed Rhei Radix et Rhizoma on upper-energizer disease and hepatic energy metabolism in mice.
  
  
  METHODS
  The streptococcal pneumonia rats model and acetic acid burning mouth ulcers rats model were established and randomly divided into three groups: model group, crude Rhei Radix et Rhizoma group and wine-processed Rhei Radix et Rhizoma group. The pathologic changes were observed after the rats had been administrated with water extracts of crude and wine-processed Rhei Radix et Rhizoma respectively. The normal ICR mice were randomly divided into three groups: control group, crude Rhei Radix et Rhizoma group and wine-processed Rhei Radix et Rhizoma group. The influence of water extracts of crude and wine-processed Rhei Radix et Rhizoma on the activities of Na+, K-ATPase, Ca2+ -ATPase and succinic dehydrogenase(SDH) in the mice were compared.
  
  
  RESULTS
  Compared with the crude one,the wine-processed Rhei Radix et Rhizoma significantly decreased the inflammation scores (P <0. 05), and promoted the tissue repair of acetic acid burning mouth ulcers rats model. The wine-processed one could also obviously reduce and normalize the level of leucocyte and neutrophilic granulocyte, lower the TNF-α level (P <0. 05), and relieve inflammatory exudation of the lung tissue. The inhibitory effects of wine-processed Rhei Radix et Rhizoma on the activities of SDH, Ca2+-ATPase and Na+, K + -ATPase were weaker than those of the crude one (P > 0. 05).
  
  
  CONCLUSIONS
  After having been processed with wine, the efficacy of Rhei Radix et Rhizoma on upper-energizer disease is enhanced, and the inhibition on the activity of energy metabolism enzyme in liver tends to be weakened.
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.forename: Tian-qi
authors.initials: TQ
authors.lastname: Rui
authors.forename: Jun-hui
authors.initials: JH
authors.lastname: Yang
authors.forename: Jun-son
authors.initials: JS
authors.lastname: Li
authors.forename: Ling-ling
authors.initials: LL
authors.lastname: Zhou
authors.forename: Bao-chang
authors.initials: BC
authors.lastname: Cai
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004734:Energy Metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D051379:Mice; D008813:Mice, Inbred ICR; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012250:Rheum / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014920:Wine
chemical_list: D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; D000251:Adenosine Triphosphatases