title: APOA II genotypes frequency and their interaction with saturated fatty acids consumption on lipid profile of patients with type 2 diabetes.
abstract: Several studies have suggested that APOA II-265T/C polymorphism affect lipid profile. The aim of this study was to investigate the effect of -265T/C APOA II polymorphism and saturated fatty acids (SFA) intake interaction on lipid profile in diabetic population who are at risk for lipid disorders.
  
  
  
  In this cross sectional study, 697 type 2 diabetic patients participated. Food consumption data were collected using validated semi-quantitative FFQ during the last year. Realtime-PCR was used to determine APOA II-265T/C genotypes. The interaction between the genotypes and SFA intake with lipid profile was tested using analysis of covariance (ANCOVA).
  
  
  
  According to APOA II-265T/C (rs5082) genotype distribution results, CC genotype with a frequency of 12.9% and TC with that of 47.7% showed the lowest and highest frequency in our population, respectively. CC genotype subjects had significantly lower total cholesterol, triglyceride, Cholesterol/HDL-c ratio and non-HDL cholesterol than T allele carriers (p = 0.009, p = 0.02, p = 0.02 and p = 0.002, respectively). The interaction between genotype and SFA intake contributed to significant higher levels of LDL-c and LDL/HDL in CCs (p = 0.05 and p = 0.01), suggesting vulnerability of these individuals to high intake of SFA in the diet.
  
  
  
  APOA II polymorphism may influence the saturated fatty acid intake required to prevent dyslipidemia in the type 2 diabetic population.
authors.affiliation: Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Noorshahi
authors.affiliation: Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Gity
authors.initials: G
authors.lastname: Sotoudeh
authors.affiliation: Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Djalali
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Eshraghian
authors.affiliation: Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Keramatipour
authors.affiliation: Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Marjan Ghane
authors.initials: MG
authors.lastname: Basiri
authors.affiliation: Department of Nutrition, Faculty of Health, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Farideh
authors.initials: F
authors.lastname: Doostan
authors.affiliation: Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: fkoohdan@tums.ac.ir.
authors.forename: Fariba
authors.initials: F
authors.lastname: Koohdani
mesh_terms: D000483:Alleles; D016633:Apolipoprotein A-II / Q000097:blood / Q000235:genetics*; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004032:Diet; D015444:Exercise; D005227:Fatty Acids / Q000008:administration & dosage*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
chemical_list: D016633:Apolipoprotein A-II; D005227:Fatty Acids; D014280:Triglycerides; D002784:Cholesterol
keywords: Apolipoprotein A II; Diabetes type 2; Lipid profiles; Saturated fatty acids