title: Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats.
abstract: OBJECTIVE
  The aim of this study is the evaluation of the influence of repeated (5 times for 15 min) exposure to electromagnetic field (EMF) of 1800 MHz frequency on tissue lipid peroxidation (LPO) both in normal and inflammatory state, combined with analgesic treatment.
  
  
  METHODS
  The concentration of malondialdehyde (MDA) as the end-product of the lipid peroxidation (LPO) was estimated in blood, liver, kidneys, and brain of Wistar rats, both healthy and those with complete Freund's adjuvant (CFA)-induced persistent paw inflammation.
  
  
  RESULTS
  The slightly elevated levels of the MDA in blood, kidney, and brain were observed among healthy rats in electromagnetic field (EMF)-exposed groups, treated with tramadol (TRAM/EMF and exposed to the EMF). The malondialdehyde remained at the same level in the liver in all investigated groups: the control group (CON), the exposed group (EMF), treated with tramadol (TRAM) as well as exposed to and treated with tramadol (TRAM/EMF). In the group of animals treated with the complete Freund's adjuvant (CFA) we also observed slightly increased values of the MDA in the case of the control group (CON) and the exposed groups (EMF and TRAM/EMF). The MDA values concerning kidneys remained at the same levels in the control, exposed, and not-exposed group treated with tramadol. Results for healthy rats and animals with inflammation did not differ significantly.
  
  
  CONCLUSIONS
  The electromagnetic field exposure (EMF), applied in the repeated manner together with opioid drug tramadol (TRAM), slightly enhanced lipid peroxidation level in brain, blood, and kidneys.
authors.affiliation: Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Microwave Safety). pbodera@gmail.com.
authors.forename: Paweł
authors.initials: P
authors.lastname: Bodera
authors.affiliation: Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Microwave Safety).
authors.forename: Wanda
authors.initials: W
authors.lastname: Stankiewicz
authors.affiliation: Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Pharmacology and Toxicology).
authors.forename: Bożena
authors.initials: B
authors.lastname: Antkowiak
authors.affiliation: Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Pharmacology and Toxicology).
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Paluch
authors.affiliation: Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Microwave Safety).
authors.forename: Jarosław
authors.initials: J
authors.lastname: Kieliszek
authors.affiliation: Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Microwave Safety).
authors.forename: Jaromir
authors.initials: J
authors.lastname: Sobiech
authors.affiliation: Military Institute of Hygiene and Epidemiology, Puławy, Poland (Biological Threat Identification and Countermeasure Center).
authors.forename: Marcin
authors.initials: M
authors.lastname: Niemcewicz
mesh_terms: D000818:Animals; D001769:Blood / Q000378:metabolism* / Q000528:radiation effects; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects; D004195:Disease Models, Animal; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D007668:Kidney / Q000378:metabolism* / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000528:radiation effects; D008099:Liver / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D018384:Oxidative Stress / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar
keywords: analgesics; electromagnetic field; lipid peroxidation; malondialdehyde; rats; tramadol