title: Torque teno virus among dialysis and renal-transplant patients.
abstract: Patients who undergo dialysis treatment or a renal transplant have a high risk of blood-borne viral infections, including the Torque teno virus (TTV). This study identified the presence of TTV and its genome groups in blood samples from 118 patients in dialysis and 50 renal-transplant recipients. The research was conducted in a hospital in the city of Maringá, state of Paraná. The viral DNA, obtained from whole blood, was identified by using two nested Polymerase Chain Reactions (PCR). The frequencies of TTV were 17% and 36% in dialysis patients using the methodology proposed by Nishizawa et al . (1997) and Devalle and Niel (2004) , respectively, and 10% and 54% among renal-transplant patients. There was no statistically significant association between the frequency of the pathogen and the variables: gender, time in dialysis, time since transplant, blood transfusions, and the concomitant presence of hepatitis B, for either the dialysis patients or the renal-transplant recipients. Among dialysis patients and renal-transplant recipients, genogroup 5 was predominant (48% and 66% respectively), followed by genogroup 4 (37% and 48%) and genogroup 1 (23% and 25%). Genogroup 2 was present in both groups of patients. Some patients had several genogroups, but 46% of the dialysis patients and 51% of the renal-transplant recipients had only a single genogroup. This study showed a high prevalence of TTV in dialysis patients and renal-transplant recipients.
authors.affiliation: Departamento de Enfermagem, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors.forename: Angélica Yukari
authors.initials: AY
authors.lastname: Takemoto
authors.affiliation: Departamento de Enfermagem, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Okubo
authors.affiliation: Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors.forename: Patricia Keiko
authors.initials: PK
authors.lastname: Saito
authors.affiliation: Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors.forename: Roger Haruki
authors.initials: RH
authors.lastname: Yamakawa
authors.affiliation: Departamento de Patologia, Universidade Estadual de Londrina, Londrina, PR, Brazil.
authors.forename: Maria Angélica Ehara
authors.initials: MA
authors.lastname: Watanabe
authors.affiliation: Departamento de Estatística, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors.forename: Waldir
authors.initials: W
authors.lastname: Veríssimo da Silva Junior
authors.affiliation: Departamento de Ciências Básicas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors.forename: Sueli Donizete
authors.initials: SD
authors.lastname: Borelli
authors.affiliation: Departamento de Enfermagem, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Bedendo
mesh_terms: D000328:Adult; D000368:Aged; D001769:Blood / Q000821:virology*; D001938:Brazil / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology / Q000821:virology; D004266:DNA Virus Infections / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D006435:Renal Dialysis; D022783:Torque teno virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D066027:Transplant Recipients; D055815:Young Adult
keywords: infection; kidney transplant; renal dialysis; torque teno virus