title: Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms.
abstract: An age-dependent model of the periodontium was reproduced to evaluate the effect of life-long feeding on a low coenzyme Q10 dosage in n-6, n-3 polyunsaturated fatty acid or monounsaturated fatty acid-based diets on periodontal tissues of young and old rats. Results shown that exacerbated age-related alveolar bone loss previously associated to n-6 polyunsaturated fatty acid diet was attenuated by coenzyme Q10 Gene expression analysis suggests that involved mechanisms might be related to a restored capacity of mitochondria to adapt to aging in gingival cells from rats fed on n-6 polyunsaturated fatty acid. In particular, this could be due to an age-related increase of the rate of mitochondrial biogenesis and a better oxidative and respiratory balance in these animals. From the nutritional and clinical point of view, it is noteworthy that supplementation with coenzyme Q10 could counteract the negative effects of n-6 polyunsaturated fatty acid on alveolar bone loss (a major feature of periodontitis) associated to age.
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Varela-Lopez
authors.affiliation: Department of Periodontology, Dental School, University of Sevilla, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Bullon
authors.affiliation: Dip. Scienze Cliniche Specialistiche ed Odontostomatologiche, Università Politecnica delle Marche, Ancona, Italia.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
authors.affiliation: Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, Spain.
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Ramirez-Tortosa
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, Spain.
authors.forename: Julio J
authors.initials: JJ
authors.lastname: Ochoa
authors.affiliation: Department of Citología e Histología Normal y Patológica, Universidad de Sevilla, Spain.
authors.forename: Mario D
authors.initials: MD
authors.lastname: Cordero
authors.affiliation: Department of Pathology, Complejo Hospitalario de Jaén, Spain.
authors.forename: César L
authors.initials: CL
authors.lastname: Ramirez-Tortosa
authors.affiliation: Dip. Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italia.
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.affiliation: Dip. Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Zizzi
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, Spain. jlquiles@ugr.es.
authors.forename: José L
authors.initials: JL
authors.lastname: Quiles
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D004032:Diet / Q000009:adverse effects*; D004195:Disease Models, Animal; D043371:Fatty Acids, Omega-6 / Q000009:adverse effects*; D008297:Male; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D043371:Fatty Acids, Omega-6; D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10
keywords: Biogenesis; Electron transport chain; Fish oil; Sunflower oil; Virgin olive oil