title: Building a Terminal: Mechanisms of Presynaptic Development in the CNS.
abstract: To create a presynaptic terminal, molecular signaling events must be orchestrated across a number of subcellular compartments. In the soma, presynaptic proteins need to be synthesized, packaged together, and attached to microtubule motors for shipment through the axon. Within the axon, transport of presynaptic packages is regulated to ensure that developing synapses receive an adequate supply of components. At individual axonal sites, extracellular interactions must be translated into intracellular signals that can incorporate mobile transport vesicles into the nascent presynaptic terminal. Even once the initial recruitment process is complete, the components and subsequent functionality of presynaptic terminals need to constantly be remodeled. Perhaps most remarkably, all of these processes need to be coordinated in space and time. In this review, we discuss how these dynamic cellular processes occur in neurons of the central nervous system in order to generate presynaptic terminals in the brain.
authors.affiliation: Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors.forename: Luke A D
authors.initials: LA
authors.lastname: Bury
authors.affiliation: Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA Department of Neuroscience, Case Western Reserve University School of Medicine, Cleveland, OH, USA shasta.sabo@case.edu.
authors.forename: Shasta L
authors.initials: SL
authors.lastname: Sabo
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism; D006801:Humans; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism*; D021381:Protein Transport; D015398:Signal Transduction; D013572:Synaptic Vesicles / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism*
chemical_list: C498440:BSN protein, human; D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C498630:PCLO protein, human
keywords: axonal transport; presynaptic; synapse formation; synaptogenesis; trans-synaptic adhesion