title: Cell membrane-inspired polymeric micelles as carriers for drug delivery.
abstract: In cancer therapy, surface engineering of drug delivery systems plays an essential role in their colloidal stability, biocompatibility and prolonged blood circulation. Inspired by the cell membrane consisting of phospholipids and glycolipids, a zwitterionic phosphorylcholine functionalized chitosan oligosaccharide (PC-CSO) was first synthesized to mimic the hydrophilic head groups of those amphipathic lipids. Then hydrophobic stearic acid (SA) similar to lipid fatty acids was grafted onto PC-CSO to form amphiphilic PC-CSO-SA copolymers. Cell membrane-mimetic micelles with a zwitterionic surface and a hydrophobic SA core were prepared by the self-assembly of PC-CSO-SA copolymers, showing excellent stability under extreme conditions including protein containing media, high salt content or a wide pH range. Doxorubicin (DOX) was successfully entrapped into polymeric micelles through the hydrophobic interaction between DOX and SA segments. After fast internalization by cancer cells, sustained drug release from micelles to the cytoplasm and nucleus was achieved. This result suggests that these biomimetic polymeric micelles may be promising drug delivery systems in cancer therapy.
authors.affiliation: National Engineering Laboratory of Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China. Zhang508@scu.edu.cn.
authors.forename: Gongyan
authors.initials: G
authors.lastname: Liu
authors.forename: Quanqing
authors.initials: Q
authors.lastname: Luo
authors.forename: Haiqi
authors.initials: H
authors.lastname: Gao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Xing
authors.initials: X
authors.lastname: Wei
authors.forename: Hong
authors.initials: H
authors.lastname: Dai
authors.forename: Zongcai
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D000970:Antineoplastic Agents; D001672:Biocompatible Materials / Q000737:chemistry*; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism*; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism*; D008823:Micelles; D009844:Oligosaccharides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008563:Membrane Lipids; D008823:Micelles; D009844:Oligosaccharides; D011108:Polymers; D013229:Stearic Acids; C031183:stearic acid; D004317:Doxorubicin; D048271:Chitosan