title: Fuchs' Uveitis Syndrome: No Longer a Syndrome?
abstract: OBJECTIVE
  Rubella virus (RV) has a central role in the etiopathogenesis of Fuchs' uveitis syndrome (FUS). We aim to offer new insights by comprehensive analysis of recent laboratory and epidemiologic data.
  
  
  METHODS
  We conducted a literature search for laboratory data and papers on etiopathogenesis.
  
  
  RESULTS
  Aqueous humour samples of FUS patients show immunoreactivity to RV, in a specific and sensitive manner. Identification of RV genome confirm intraocular infection in a subset of FUS patients. Epidemiologic findings further support causality. The clinical spectrum of RV-associated uveitis is similar but not identical to FUS. FUS eyes exhibit a predominance of CD8 + T cells, high IFN-? and IL-10 levels.
  
  
  CONCLUSIONS
  RV is the leading cause of FUS. Cytokine-based findings mirror a viral etiology and chronic low-grade inflammation. RV-associated FUS represents a common pathway of intraocular RV inoculation after congenital or acquired infection. Other causes, including HSV and CMV, may lead to FUS.
authors.affiliation: a University Hospital Ghent , Ophthalmology , Ghent , Belgium and.
authors.forename: Elke Olivia
authors.initials: EO
authors.lastname: Kreps
authors.affiliation: a University Hospital Ghent , Ophthalmology , Ghent , Belgium and.
authors.forename: Thierry
authors.initials: T
authors.lastname: Derveaux
authors.affiliation: b University Hospital Ghent , Immunology , Ghent , Belgium.
authors.forename: Filip
authors.initials: F
authors.lastname: De Keyser
authors.affiliation: a University Hospital Ghent , Ophthalmology , Ghent , Belgium and.
authors.forename: Philippe
authors.initials: P
authors.lastname: Kestelyn
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001082:Aqueous Humor / Q000821:virology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D015828:Eye Infections, Viral / Q000276:immunology / Q000821:virology*; D005642:Fuchs' Endothelial Dystrophy / Q000276:immunology / Q000821:virology*; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D012409:Rubella / Q000276:immunology / Q000821:virology*; D012412:Rubella virus / Q000235:genetics / Q000276:immunology; D014605:Uveitis / Q000276:immunology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral
keywords: Cytokines; Fuchs’ uveitis syndrome; etiology; immunology; rubella virus