title: Drug Discovery for Paediatric Chagas Disease.
abstract: Chagas disease is caused by the parasite Trypanosoma cruzi and is regularly found among particular people living in Central and South America. Paediatric Chagas disease occurs in 1-10% of infants of infected mothers. The major important point considered in the treatment of congenital Chagas disease focuses on killing the parasite in acute infection and managing signs and symptoms in later stages. Nowadays, two drugs benznidazole and nifurtimox are currently available in the market for the treatment of paediatric Chagas disease.
authors.affiliation: National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fundacao Oswaldo Cruz - Ministerio da Saude, Av. Brazil 4036 - Predio da Expansao, 8º Andar - Sala 814, Manguinhos, 21040-361 - Rio de Janeiro - RJ, Brazil.
authors.forename: Sreekanth
authors.initials: S
authors.lastname: Thota
authors.affiliation: National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fundacao Oswaldo Cruz - Ministerio da Saude, Av. Brazil 4036 - Predio da Expansao, 8º Andar - Sala 814, Manguinhos, 21040-361 - Rio de Janeiro - RJ, Brazil.
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Morel
mesh_terms: D000977:Antiparasitic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology*; D055808:Drug Discovery; D006801:Humans; D009547:Nifurtimox / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000977:Antiparasitic Agents; D009593:Nitroimidazoles; D009547:Nifurtimox; C009999:benzonidazole
keywords: Chagas disease; Trypanosoma cruzi; congenital; infants; symptoms; treatment.