title: Cell membrane-camouflaged nanoparticles for drug delivery.
abstract: Nanoparticles can preferentially accumulate at sites of action and hold great promise to improve the therapeutic index of many drugs. While conventional methods of nanocarrier-mediated drug delivery have focused on primarily synthetic approaches, engineering strategies that combine synthetic nanoparticles with natural biomaterials have recently gained much attention. In particular, cell membrane-camouflaged nanoparticles are a new class of biomimetic nanoparticles that combine the unique functionalities of cellular membranes and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents. Herein, we report on the recent progress on cell membrane-coated nanoparticles for drug delivery. In particular, we highlight three areas: (i) prolonging systemic circulation via cell membrane coating, (ii) cell-specific targeting via cell membrane coating, and (iii) applications of cell membrane coating for drug delivery. The cell membrane-camouflaged nanoparticle platform has emerged as a novel delivery strategy with the potential to improve the therapeutic efficacy for the treatment of a variety of diseases.
authors.affiliation: Department of NanoEngineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, United States.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Luk
authors.affiliation: Department of NanoEngineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address: zhang@ucsd.edu.
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D040761:Biomimetic Materials; D032701:Biomimetics; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers; D006801:Humans; D053758:Nanoparticles; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D010599:Pharmacokinetics
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations
keywords: Biomimetic nanoparticle; Cell membrane; Drug delivery; Nanomedicine; Targeted delivery