title: A Model-Based Illustrative Exploratory Approach to Optimize the Dosing of Peg-IFN/RBV in Cirrhotic Hepatitis C Patients Treated With Triple Therapy.
abstract: Hézode et al. recently reported the frequent occurrence of anemia and thrombocytopenia in the ANRS-CO20-CUPIC cohort of hepatitis C virus (HCV) cirrhotic experienced patients treated with pegylated-interferon (Peg-IFN), ribavirin (RBV), and telaprevir or boceprevir.1,2 Using frequent measurements of serum drug concentrations, hemoglobin, and platelet concentrations obtained in 15 patients of this cohort, we show how an on-treatment model-based approach could be used to individualize dose regimen and avoid the occurrence of RBV-induced anemia and Peg-IFN-induced thrombocytopenia.
authors.affiliation: INSERM, IAME, UMR 1137, Univ Paris Diderot Sorbonne Paris Cité, Paris, France ; AP-HP, Hôpital Bichat, Departement of Biostatistic Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Laouénan
authors.affiliation: INSERM, IAME, UMR 1137, Univ Paris Diderot Sorbonne Paris Cité, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Guedj
authors.affiliation: INSERM, IAME, UMR 1137, Univ Paris Diderot Sorbonne Paris Cité, Paris, France ; AP-HP, Hôpital Bichat, Department of Pharmaco-Toxicology Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Peytavin
authors.affiliation: INSERM, IAME, UMR 1137, Univ Paris Diderot Sorbonne Paris Cité, Paris, France.
authors.forename: Th Tram
authors.initials: TT
authors.lastname: Nguyen
authors.affiliation: INSERM, CRI Paris Montmartre, UMR 1149, Univ Paris Diderot Clichy, France.
authors.forename: M
authors.initials: M
authors.lastname: Lapalus
authors.affiliation: AP-HP, Hôpital Beaujon, Hepatology, Physiopathology and Treatment of Viral Hepatitis Clichy, France.
authors.forename: F
authors.initials: F
authors.lastname: Khelifa-Mouri
authors.affiliation: AP-HP, Hôpital Beaujon, Hepatology, Physiopathology and Treatment of Viral Hepatitis Clichy, France.
authors.forename: N
authors.initials: N
authors.lastname: Boyer
authors.affiliation: INSERM, UMR 1052, Univ Lyon Lyon, France ; Hospices Civils de Lyon, Department of Hepatology Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Zoulim
authors.affiliation: AP-HP, Hôpital Saint-Antoine, Department of Hepatology Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Serfaty
authors.affiliation: INSERM, UMR 954, Univ Lorraine Vandoeuvre-les-Nancy, France ; Centre Hospitalier Universitaire de Nancy, Department of Hepatology Vandoeuvre-les-Nancy, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Bronowicki
authors.affiliation: INSERM, CRI Paris Montmartre, UMR 1149, Univ Paris Diderot Clichy, France.
authors.forename: M
authors.initials: M
authors.lastname: Martinot-Peignoux
authors.affiliation: INSERM, CRI Paris Montmartre, UMR 1149, Univ Paris Diderot Clichy, France.
authors.forename: O
authors.initials: O
authors.lastname: Lada
authors.affiliation: INSERM, CRI Paris Montmartre, UMR 1149, Univ Paris Diderot Clichy, France ; AP-HP, Hôpital Beaujon, Hepatology, Physiopathology and Treatment of Viral Hepatitis Clichy, France.
authors.forename: T
authors.initials: T
authors.lastname: Asselah
authors.affiliation: INSERM, UMR 1136, Univ Pierre et Marie Curie Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Dorival
authors.affiliation: INSERM, UMR 955, Univ Paris-Est Créteil, France ; AP-HP, Hôpital Henri Mondor, Department of Hepatology Créteil, France.
authors.forename: C
authors.initials: C
authors.lastname: Hézode
authors.affiliation: INSERM, UMR 1136, Univ Pierre et Marie Curie Paris, France ; AP-HP, Hôpital Saint-Antoine, Department of Public Health Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Carrat
authors.affiliation: CHU Toulouse, IFB Purpan, Virology Laboratory Toulouse, France.
authors.forename: F
authors.initials: F
authors.lastname: Nicot
authors.affiliation: INSERM, CRI Paris Montmartre, UMR 1149, Univ Paris Diderot Clichy, France ; AP-HP, Hôpital Beaujon, Hepatology, Physiopathology and Treatment of Viral Hepatitis Clichy, France.
authors.forename: P
authors.initials: P
authors.lastname: Marcellin
authors.affiliation: INSERM, IAME, UMR 1137, Univ Paris Diderot Sorbonne Paris Cité, Paris, France ; AP-HP, Hôpital Bichat, Departement of Biostatistic Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Mentré