title: The Emerging Role of miR-223 in Platelet Reactivity: Implications in Antiplatelet Therapy.
abstract: Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant miRNAs in megakaryocytes and platelets. One of the miR-223-regulated genes is ADP P2Y12, a key target for current antiplatelet drug therapy. Recent studies showed that a blunted response to P2Y12 antagonist, that is, high on-treatment platelet reactivity (HTPR), is a strong predictor of major cardiovascular events (MACEs) in coronary heart disease (CHD) patients receiving antiplatelet treatment. Recent clinical cohort study showed that the level of circulating miR-223 is inversely associated with MACE in CHD patients. In addition, our recent data demonstrated that the level of both intraplatelet and circulating miR-223 is an independent predictor for HTPR, thus providing a link between miR-223 and MACE. These lines of evidence indicate that miR-223 may serve as a potential regulatory target for HTPR, as well as a diagnostic tool for identification of HTPR in clinical settings.
authors.affiliation: Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces, 220 Cheng-Lin Road, Tianjin 300162, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Shi
authors.affiliation: Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces, 220 Cheng-Lin Road, Tianjin 300162, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces, 220 Cheng-Lin Road, Tianjin 300162, China.
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Ji
authors.affiliation: Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces, 220 Cheng-Lin Road, Tianjin 300162, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces, 220 Cheng-Lin Road, Tianjin 300162, China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Ma
authors.affiliation: Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces, 220 Cheng-Lin Road, Tianjin 300162, China.
authors.forename: Jian-Qi
authors.initials: JQ
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces, 220 Cheng-Lin Road, Tianjin 300162, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Li
mesh_terms: D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D003327:Coronary Disease / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D008533:Megakaryocytes / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D058925:Receptors, Purinergic P2Y12 / Q000187:drug effects / Q000235:genetics
chemical_list: D035683:MicroRNAs; D010975:Platelet Aggregation Inhibitors; D058925:Receptors, Purinergic P2Y12; C525067:MIR223, human; C548576:P2RY12 protein, human