title: Hedgehog signaling and radiation induced liver injury: a delicate balance.
abstract: Radiation-induced liver disease (RILD) is a major limitation of radiation therapy (RT) for the treatment of liver cancer. Emerging data indicate that hedgehog (Hh) signaling plays a central role in liver fibrosis and regeneration after liver injury. Here, we review the potential role of Hh signaling in RILD and propose the temporary use of Hh inhibition during liver RT to radiosensitize HCC tumor cells and inhibit their progression, while blocking the initiation of the radiation-induced fibrotic response in the surrounding normal liver.
authors.affiliation: Department of Radiation Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210 Street, Bronx, NY, 10467, USA.
authors.forename: Rafi
authors.initials: R
authors.lastname: Kabarriti
authors.affiliation: Department of Radiation Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210 Street, Bronx, NY, 10467, USA. cguhamd@gmail.com.|Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA. cguhamd@gmail.com.
authors.forename: Chandan
authors.initials: C
authors.lastname: Guha
keywords: Hedgehog signaling; Radiation-induced liver disease