title: T Cells and Cerebral Ischemic Stroke.
abstract: Stroke results in cerebral inflammation that causes brain injury and triggers immunodepression, resulting in an increased incidence of morbidity and mortality secondary to remote infection. It is well known that T cells modulate brain inflammation after ischemic stroke, and targeting T cells may be an innovative therapeutic strategy for stroke treatment. T cell deficiency is neuro-protective, but the observed protective effects differ between ischemic models. Recent studies suggest different T cell subsets may have distinct effects on the injured brain. In addition to their role in cerebral inflammation, T cells also play a role in stroke-induced immunodepression. Therefore, T cell-targeted therapies designed to provide protection against brain inflammation might paradoxically contribute to remote organ infection and mortality. Further investigations are required to determine the role of specific T cell subsets in cerebral inflammation and stroke-induced immunodepression, the optimal therapeutic window for treatment, and the appropriate dose of anti-T cell therapy.
authors.affiliation: Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Gu
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Jian
authors.forename: Creed
authors.initials: C
authors.lastname: Stary
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Xiong
mesh_terms: D002545:Brain Ischemia / Q000276:immunology*; D006801:Humans; D020521:Stroke / Q000276:immunology*; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes / Q000276:immunology*