title: [Analysis of Musculoskeletal Systems and Their Diseases. The role of extracellular matrix and its pathogenesis in musculoskeletal disorders].
abstract: Extracellular matrix is present in all organs, but its strength and character differ greatly from structure to structure. Organs in the musculoskeletal system require tissue specific strength, resistance to strains and elasticity. Extracellular matrix that forms the scaffold in tissues, is able to detect mechanical stress, and undergoes remodeling to dissipate the strain. Here we explain how excess mechanical and biochemical stresses disrupt normal matrix remodeling resulting in reduced strength/elasticity.
authors.affiliation: Department of Orthopaedic Surgery, Jikei University School of Medicine, Japan./Systems Biomedicine, Tokyo Medical and Dental University, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kayama
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Saito
authors.forename: Keishi
authors.initials: K
authors.lastname: Marumo
mesh_terms: D005109:Extracellular Matrix / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D009140:Musculoskeletal Diseases / Q000378:metabolism* / Q000503:physiopathology*; D018384:Oxidative Stress; D013314:Stress, Mechanical