title: HYPOGLYCEMIA INDUCED BY ANTIDIABETIC SULFONYLUREAS.
abstract: Diabetes mellitus is a major health problem due to its increasing prevalence and life-threatening complications. Antidiabetic sulfonylureas represent the first-line drugs in type 2 diabetes even though the most common associated risk is pharmacologically-induced hypoglycemia. In the development of this side effect are involved several factors including the pharmacokinetic and pharmacodynamic profile of the drug, patient age and behavior, hepatic or renal dysfunctions, or other drugs associated with a high risk of interactions. If all these are controlled, the risk-benefit balance can be equal to other oral antidiabetic drugs.
authors.forename: Luminiţa
authors.initials: L
authors.lastname: Confederat
authors.forename: Sandra
authors.initials: S
authors.lastname: Constantin
authors.forename: Florentina
authors.initials: F
authors.lastname: Lupaşcu
authors.forename: Andreea
authors.initials: A
authors.lastname: Pânzariu
authors.forename: Monica
authors.initials: M
authors.lastname: Hăncianu
authors.forename: Lenuţa
authors.initials: L
authors.lastname: Profire
mesh_terms: D002747:Chlorpropamide / Q000009:adverse effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005907:Gliclazide / Q000009:adverse effects; D005913:Glipizide / Q000009:adverse effects; D005905:Glyburide / Q000009:adverse effects; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D014044:Tolbutamide / Q000009:adverse effects
chemical_list: D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D014044:Tolbutamide; C010969:gliquidone; D005907:Gliclazide; D005905:Glyburide; D002747:Chlorpropamide; D005913:Glipizide