title: Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  Obstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome.
  
  
  METHODS
  We prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI): (1) AHIlow group: 5≤AHI<15, (2) AHImid group: 15<AHI≤30, and (3) AHIhigh group: AHI>30.
  
  
  RESULTS
  The highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (β=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (β=0.194, p=0.010).
  
  
  CONCLUSIONS
  The MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome.
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Çukurova/Adana, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Akyol
authors.affiliation: Department of Pulmonology, Adana Numune Training and Research Hospital, Çukurova/Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çörtük
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Çukurova/Adana, Turkey.
authors.forename: Ahmet Oytun
authors.initials: AO
authors.lastname: Baykan
authors.affiliation: Department of Pulmonology, Antalya Numune Training and Research Hospital, Turkey., Antalya.
authors.forename: Kemal
authors.initials: K
authors.lastname: Kiraz
authors.affiliation: Department of Cardiology, Kafkas University School of Medicine, Kars, Turkey.
authors.forename: Abdurrezzak
authors.initials: A
authors.lastname: Börekçi
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Çukurova/Adana, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.affiliation: Department of Cardiology, Kafkas University School of Medicine, Kars, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Çukurova/Adana, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Çayli
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D017286:Polysomnography; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis*
chemical_list: D002097:C-Reactive Protein