title: Contrast Media for X-ray and Magnetic Resonance Imaging: Development, Current Status and Future Perspectives.
abstract: Over the last 120 years, the extensive advances in medical imaging allowed enhanced diagnosis and therapy of many diseases and thereby improved the quality of life of many patient generations. From the beginning, all technical solutions and imaging procedures were combined with dedicated pharmaceutical developments of contrast media, to further enhance the visualization of morphology and physiology. This symbiosis of imaging hardware and contrast media development was of high importance for the development of modern clinical radiology. Today, all available clinically approved contrast media fulfill the highest requirements for clinical safety and efficacy. All new concepts to increase the efficacy of contrast media have also to consider the high clinical safety standards and cost of goods of current marketed contrast media. Nevertheless, diagnostic imaging will contribute significantly to the progresses in medicine, and new contrast media developments are mandatory to address the medical needs of the future.
authors.affiliation: From the *MR and CT Contrast Media Research, Bayer Healthcare AG; †Department of Physical and Theoretical Chemistry, Free University; ‡Department of Radiology, Charite-Universitätsmedizin Berlin, Campus Benjamin Franklin; and §Clinical Project Management General Medicine, Bayer Healthcare AG, Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Frenzel
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Lawaczeck
authors.forename: Matthias
authors.initials: M
authors.lastname: Taupitz
authors.forename: Gregor
authors.initials: G
authors.lastname: Jost
authors.forename: Jessica
authors.initials: J
authors.lastname: Lohrke
authors.forename: Martin A
authors.initials: MA
authors.lastname: Sieber
authors.forename: Hubertus
authors.initials: H
authors.lastname: Pietsch
mesh_terms: D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends*; D011859:Radiography / Q000379:methods* / Q000639:trends*; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000639:trends
chemical_list: D003287:Contrast Media