title: A new era of therapy for hepatitis C virus infection.
abstract: OBJECTIVE
  Previous treatments with pegylated interferon (PEG-IFN) and ribavirin for hepatitis C virus (HCV) infection resulted in significant adverse events and low cure rates, even with the addition of first-generation protease inhibitors. The standard of care for chronic HCV infection changed dramatically in 2013 with the approval of second-generation direct-acting antivirals, which led the way for IFN-free combination regimens.
  
  
  RESULTS
  All-oral combinations of direct-acting antivirals, with or without ribavirin, have shown high efficacy and are well tolerated in patients with the predominant genotypes, advanced fibrosis stages, and HIV co-infection. New fixed-dose co-formulations of direct-acting antivirals have allowed simpler regimens with shorter treatment durations and low rates of discontinuation, but are associated with substantial costs.
  
  
  CONCLUSIONS
  Since 2013, all-oral, IFN-free regimens with direct-acting antivirals have quickly become the mainstay of treatment for HCV infection as they provide high rates of sustained virologic response with a relatively short duration of treatment and low side-effect profile.
authors.affiliation: University of Texas Medical Branch, Galveston, Texas, USA.
authors.forename: Harita
authors.initials: H
authors.lastname: Nyalakonda
authors.forename: Netanya S
authors.initials: NS
authors.lastname: Utay
mesh_terms: D000284:Administration, Oral; D000998:Antiviral Agents; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans
chemical_list: D000998:Antiviral Agents