title: An Efficient One-Pot Approach to the Construction of Chiral Nitrogen-Containing Heterocycles under Mild Conditions.
abstract: A new, general, and practical procedure for the highly enantioselective synthesis of functionalized nitrogen-containing heterocycles has been developed. The simple cyclic hemiaminals were directly catalyzed for the first time as nucleophiles in an enamine-based asymmetric conjugate addition reaction. The practical approach recycles the catalyst and solvent which make it possible for large-scale and diversity-oriented chemical production.
authors.affiliation: †Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China.
authors.forename: Huan-Xi
authors.initials: HX
authors.lastname: Feng
authors.affiliation: ‡School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, P. R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Tan
authors.affiliation: †Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China.
authors.forename: Yan-Kai
authors.initials: YK
authors.lastname: Liu