title: Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system.
abstract: In the course of searching for insecticides from soil microorganisms, we found that a fermentation broth of the fungus, Trichoderma brevicompactum FKI-6324, produced Trichopolyn VI, a new peptaibol, which possessed significant insecticidal potential. Spectroscopic analysis showed the compound to be a new trichopolyn I derivative. This paper describes the isolation, structure elucidation and biological activity of trichopolyn VI.
authors.affiliation: Graduate School of Infection Control Sciences, Kitasato University.
authors.forename: Takuya
authors.initials: T
authors.lastname: Suga
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Asami
authors.forename: Shohei
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nonaka
authors.forename: Masato
authors.initials: M
authors.lastname: Iwatsuki
authors.forename: Takuji
authors.initials: T
authors.lastname: Nakashima
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Ryohei
authors.initials: R
authors.lastname: Sugahara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shiotsuki
authors.forename: Takenori
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Naoya
authors.initials: N
authors.lastname: Ichimaru
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Murai
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ōmura
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
mesh_terms: D023181:Antimicrobial Cationic Peptides; D005285:Fermentation; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D000226:Mitochondrial ADP, ATP Translocases / Q000037:antagonists & inhibitors / Q000235:genetics; D054848:Peptaibols / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics; D014242:Trichoderma / Q000145:classification / Q000378:metabolism*
chemical_list: D023181:Antimicrobial Cationic Peptides; D007306:Insecticides; D054848:Peptaibols; D010455:Peptides; C016160:trichopolyn; D000226:Mitochondrial ADP, ATP Translocases