title: Amphiphilic Nanoparticles Control the Growth and Stability of Lipid Bilayers with Open Edges.
abstract: Molecular amphiphiles self-assemble in polar media to form ordered structures such as micelles and vesicles essential to a broad range of industrial and biological processes. Some of these architectures such as bilayer sheets, helical ribbons, and hollow tubules are potentially useful but inherently unstable owing to the presence of open edges that expose the hydrophobic bilayer core. Here, we describe a strategy to stabilize open bilayer structures using amphiphilic nanoparticle surfactants that present mixtures of hydrophilic and hydrophobic ligands on their surface. We observe that these particles bind selectively to the open edge of bilayer membranes to stabilize otherwise transient amphiphile assemblies. We show how such particles can precisely control the size of lipid tubules, how they can inhibit the formation of undesirable assemblies such as gallstone precursors, and how they can stabilize free-floating lipid microdiscs.
authors.affiliation: Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802 (USA).
authors.forename: Sun Hae Ra
authors.initials: SH
authors.lastname: Shin
authors.affiliation: Department of Energy and Chemical Engineering, Kumoh National Institute of Technology, Gumi, 730-701 (Republic of Korea).
authors.forename: Hee-Young
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802 (USA). kjmbishop@engr.psu.edu.
authors.forename: Kyle J M
authors.initials: KJ
authors.lastname: Bishop
mesh_terms: D008051:Lipid Bilayers; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles
chemical_list: D008051:Lipid Bilayers
keywords: lipids; membranes; nanoparticles; self-assembly