title: The frequencies of Killer immunoglobulin-like receptors and their HLA ligands in chronic inflammatory demyelinating polyradiculoneuropathy are similar to those in Guillian Barre syndrome but differ from those of controls, suggesting a role for NK cells in pathogenesis.
abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired inflammatory neuropathy, which has similar clinical and pathological features to Guillain-Barré Syndrome (GBS), but differs in time course. We investigated the frequency of genes encoding Killer immunoglobulin-like receptors and their HLA ligands in subjects with CIDP, in subjects with GBS and in healthy controls. There were no differences in KIR gene frequency among the 3 groups. The gene frequencies for HLA-B Bw4-I were significantly greater in CIDP than HC, but did not differ from GBS. The frequency of the combination of 3DL1/HLA-B Bw4I was greater in CIDP than HC, but did not differ from that of GBS. These data raise the possibility of NK cell function being an important factor in the pathogenesis of CIDP.
authors.affiliation: Royal Brisbane and Women's Hospital, Department of Neurology, Butterfield Street, Herston QLD 4029, Australia; University of Queensland, Centre for Clinical Research, Herston Campus, Herston, QLD 4029, Australia.
authors.forename: Stefan
authors.initials: S
authors.lastname: Blum
authors.affiliation: University of Queensland, Centre for Clinical Research, Herston Campus, Herston, QLD 4029, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Csurhes
authors.affiliation: Royal Brisbane and Women's Hospital, Department of Neurology, Butterfield Street, Herston QLD 4029, Australia; University of Queensland, Centre for Clinical Research, Herston Campus, Herston, QLD 4029, Australia.
authors.forename: Pamela
authors.initials: P
authors.lastname: McCombe
mesh_terms: D015331:Cohort Studies; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism*; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D008297:Male; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism*; D054340:Receptors, KIR / Q000276:immunology / Q000378:metabolism*
chemical_list: D006680:HLA Antigens; D008024:Ligands; D054340:Receptors, KIR
keywords: Chronic inflammatory demyelinating polyradiculoneuropathy; Guillain–Barré Syndrome; Human leucocyte antigen; Killer immunoglobulin-like receptors; NK cells