title: A purification system for64Cu produced by a biomedical cyclotron for antibody PET imaging.
abstract: Ion exchange is a simple and efficient method for separating no-carrier-added64Cu from an irradiated Ni target. We developed a semi-automated two-round64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of64Cu from the Ni target was achieved with high radiochemical purity.64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.
authors.affiliation: Department of Radiation Research, Advanced Science Research Center, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 Japan ; Graduate School of Health Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Toyota
authors.affiliation: Department of Radiation Research, Advanced Science Research Center, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hanafusa
authors.affiliation: Quantum Equipment Division, Sumitomo Heavy Industries, Ltd., 2-1-1 Osaki, Shinagawa-ku, Tokyo, 141-6025 Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Oda
authors.affiliation: Quantum Equipment Division, Sumitomo Heavy Industries, Ltd., 2-1-1 Osaki, Shinagawa-ku, Tokyo, 141-6025 Japan.
authors.forename: Iwane
authors.initials: I
authors.lastname: Koumura
authors.affiliation: Collaborative Research Center for Okayama Medical Innovation Center, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Sasaki
authors.affiliation: Collaborative Research Center for Okayama Medical Innovation Center, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Matsuura
authors.affiliation: Collaborative Research Center for Okayama Medical Innovation Center, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumon
authors.affiliation: Quantum Equipment Division, Sumitomo Heavy Industries, Ltd., 2-1-1 Osaki, Shinagawa-ku, Tokyo, 141-6025 Japan ; Collaborative Research Center for Okayama Medical Innovation Center, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Yano
authors.affiliation: Department of Radiation Research, Advanced Science Research Center, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ono
keywords: 64Cu; Anion exchange chromatography; Atomic absorption spectrometry; Cyclotron; Positron emission tomography (PET)