title: Ruthenium-catalyzed cyclization of N-carbamoyl indolines with alkynes: an efficient route to pyrroloquinolinones.
abstract: A regioselective synthesis of substituted pyrroloquinolinones via a ruthenium-catalyzed oxidative cyclization of substituted N-carbamoyl indolines with alkynes is described. The cyclization reaction was compatible with various symmetrical and unsymmetrical alkynes including substituted propiolates. Later, we performed the aromatization of pyrroloquinolinones into indole derivatives in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ).
authors.affiliation: Department of Chemistry, Indian Institution of Science Education and Research, Pune 411021, Maharashtra, India. mjeganmohan@iiserpune.ac.in.
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Manoharan
authors.forename: Masilamani
authors.initials: M
authors.lastname: Jeganmohan
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011758:Pyrroles / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D016227:Benzoquinones; D007211:Indoles; D011758:Pyrroles; D011804:Quinolines; C410406:pyrroloquinoline; C000928:dichlorodicyanobenzoquinone; C057812:indoline; D012428:Ruthenium