title: Palladium-Catalyzed Oxidative Cross-Coupling of Conjugated Enynones with Organoboronic Acids.
abstract: A palladium-catalyzed oxidative cross-coupling reaction of conjugated enynones with organoboronic acids is developed. This reaction provides an efficient methodology for the synthesis of functionalized furan derivatives, including 2-alkenylfurans and furan-substituted 1,3-dienes. Palladium-carbene migratory insertion is proposed as the key step in these transformations. Notably, the β-hydride elimination process occurs in a stereoselective manner, resulting in the formation of double bonds with high (E)-selectivity.
authors.affiliation: †Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xia
authors.affiliation: †Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ge
authors.affiliation: †Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: †Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: †Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: †Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: †Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.|‡State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001897:Boronic Acids; D005663:Furans; D007659:Ketones; D009942:Organometallic Compounds; D010165:Palladium