title: Hypertension in patients with Alzheimer's disease--prevalence, characteristics, and impact on clinical outcome. Experience of one neurology center in Poland.
abstract: The aim of the study was to evaluate hypertension (HT) prevalence, characteristics, and impact on clinical outcome in patients with Alzheimer's disease (AD). We evaluated 701 patients with AD (249 males, 452 females, and mean age 74.9 ± 7.5 years). As a group representing general population matched with regard to age, education level, and place of residence, we included 762 subjects (438 males, 324 females, and mean age 74.7 ± 4.4 years) from the Polish National Multicenter Health Survey (WOBASZ) studies. The patients with AD were characterized by lower systolic blood pressure (BP) and diastolic BP values (134 ± 21 vs. 151 ± 23 mm Hg, P < .001 and 77 ± 11 vs. 86 ± 12 mm Hg, P < .001, respectively) as well as lower HT prevalence (66% vs. 78.6%, P < .001) compared with the WOBASZ group. In long-term follow-up of AD group, HT and BP levels were not associated with the decline in cognitive functions nor the increased risk of death. Patients with AD were characterized by lower prevalence of HT and other vascular risk factors. BP levels and HT had no impact on clinical outcome.
authors.affiliation: Department of Hypertension, Institute of Cardiology, Warsaw, Poland. Electronic address: ewarchol@ikard.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Warchol-Celinska
authors.affiliation: Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Styczynska
authors.affiliation: Department of Hypertension, Institute of Cardiology, Warsaw, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Prejbisz
authors.affiliation: Department of Hypertension, Institute of Cardiology, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Przybylowska
authors.affiliation: Department of Neurology, Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Chodakowska-Zebrowska
authors.affiliation: Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Warsaw, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Kurjata
authors.affiliation: Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Warsaw, Poland.
authors.forename: Walerian
authors.initials: W
authors.lastname: Piotrowski
authors.affiliation: Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Polakowska
authors.affiliation: Department of Hypertension, Institute of Cardiology, Warsaw, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Kabat
authors.affiliation: Department of Preventive Medicine and Education, Medical University of Gdansk, Gdańsk, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zdrojewski
authors.affiliation: Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Drygas
authors.affiliation: Department of Hypertension, Institute of Cardiology, Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Januszewicz
authors.affiliation: Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Barcikowska
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000401:mortality*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D011044:Poland / Q000453:epidemiology; D015995:Prevalence
keywords: Alzheimer's disease; dementia; hypertension; mortality