title: KnowEnG: a knowledge engine for genomics.
abstract: We describe here the vision, motivations, and research plans of the National Institutes of Health Center for Excellence in Big Data Computing at the University of Illinois, Urbana-Champaign. The Center is organized around the construction of "Knowledge Engine for Genomics" (KnowEnG), an E-science framework for genomics where biomedical scientists will have access to powerful methods of data mining, network mining, and machine learning to extract knowledge out of genomics data. The scientist will come to KnowEnG with their own data sets in the form of spreadsheets and ask KnowEnG to analyze those data sets in the light of a massive knowledge base of community data sets called the "Knowledge Network" that will be at the heart of the system. The Center is undertaking discovery projects aimed at testing the utility of KnowEnG for transforming big data to knowledge. These projects span a broad range of biological enquiry, from pharmacogenomics (in collaboration with Mayo Clinic) to transcriptomics of human behavior.
authors.affiliation: Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA sinhas@illinois.edu.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sinha
authors.affiliation: Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Pharmacology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Weinshilboum
authors.affiliation: Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Jongeneel
authors.affiliation: Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Han
mesh_terms: D066264:Datasets as Topic; D023281:Genomics; D006801:Humans; D051188:Knowledge Bases; D009316:National Institutes of Health (U.S.); D014481:United States
keywords: BD2K; Network analysis; big data; genomics; scalable