title: Vitamin D supplements in chronic kidney disease.
abstract: Chronic kidney disease (CKD) is a significant public health problem and Vitamin D deficiency is prevalent in CKD and might be associated with calcium and phosphate metabolism, cardiovascular disease, infections as well as the progress of kidney dysfunction. Emerging evidence implies that Vitamin D supplements may be of benefit to CKD. Based on existing laboratory and clinical evidence, this review intends to discuss the effectiveness of Vitamin D supplements and controversy in clinical practice. The effect of Vitamin D in CKD patients is summarized in detail from CKD-mineral bone disease, the progression of renal function, cardiovascular events and immune system. Considerable disputes exist for the Vitamin D supplements in CKD, and a growing amount of experimental evidence and some clinical evidence are now gathering from in vitro, animal and epidemiological studies.
authors.affiliation: a Department of Nephrology , Shanghai Jiao Tong University Affiliated First People's Hospital , Shanghai , P.R. China and.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhu
authors.affiliation: a Department of Nephrology , Shanghai Jiao Tong University Affiliated First People's Hospital , Shanghai , P.R. China and.|b Division of Nephrology and Clinical Immunology , University Hospital , RWTH Aachen , Aachen , Germany.
authors.forename: Jialin
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Department of Nephrology , Shanghai Jiao Tong University Affiliated First People's Hospital , Shanghai , P.R. China and.
authors.forename: Lijie
authors.initials: L
authors.lastname: Gu
authors.affiliation: a Department of Nephrology , Shanghai Jiao Tong University Affiliated First People's Hospital , Shanghai , P.R. China and.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: a Department of Nephrology , Shanghai Jiao Tong University Affiliated First People's Hospital , Shanghai , P.R. China and.
authors.forename: Weijie
authors.initials: W
authors.lastname: Yuan
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D018570:Risk Assessment; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications
chemical_list: D014807:Vitamin D
keywords: CKD; Vitamin D; Vitamin D analogs; Vitamin D deficiency; Vitamin D supplements