title: Augmentation of Creatine in the Heart.
abstract: Creatine is a principle component of the creatine kinase (CK) phosphagen system common to all vertebrates. It is found in excitable cells, such as cardiomyocytes, where it plays an important role in the buffering and transport of chemical energy to ensure that supply meets the dynamic demands of the heart. Multiple components of the CK system, including intracellular creatine levels, are reduced in heart failure, while ischaemia and hypoxia represent acute crises of energy provision. Elevation of myocardial creatine levels has therefore been suggested as potentially beneficial, however, achieving this goal is not trivial. This mini-review outlines the evidence in support of creatine elevation and critically examines the pharmacological approaches that are currently available. In particular, dietary creatine-supplementation does not sufficiently elevate creatine levels in the heart due to subsequent down-regulation of the plasma membrane creatine transporter (CrT). Attempts to increase passive diffusion and bypass the CrT, e.g. via creatine esters, have yet to be tested in the heart. However, studies in mice with genetic overexpression of the CrT demonstrate proof-of-principle that elevated creatine protects the heart from ischaemia-reperfusion injury. This suggests activation of the CrT as a major unmet pharmacological target. However, translation of this finding to the clinic will require a greater understanding of CrT regulation in health and disease and the development of small molecule activators.
authors.forename: Sevasti
authors.initials: S
authors.lastname: Zervou
authors.forename: Hannah J
authors.initials: HJ
authors.lastname: Whittington
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Russell
authors.affiliation: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington OX3 7BN, UK. clygate@well.ox.ac.uk.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Lygate
mesh_terms: D000818:Animals; D003401:Creatine / Q000378:metabolism*; D003402:Creatine Kinase / Q000378:metabolism; D004195:Disease Models, Animal; D015870:Gene Expression; D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000517:prevention & control*; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics*; D051379:Mice; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism
chemical_list: D026901:Membrane Transport Proteins; C080679:creatine transporter; D003402:Creatine Kinase; D003401:Creatine