title: Alien Limb Syndrome Responsive to Amantadine in a Patient with Corticobasal Syndrome.
abstract: BACKGROUND
  Corticobasal syndrome (CBS) is a complex neurodegenerative disorder associated with parkinsonism and alien limb syndrome. Dressing and ideomotor apraxia were reportedly responsive to amantadine.
  
  
  METHODS
  A 79-year-old female was referred for evaluation of right hemiparesis. Neurological examination showed dementia, normal ocular movements, mild facial hypomimia, and bradykinesia with right hemiparesis. Nine years later, she developed alien limb syndrome and was diagnosed with CBS. After failure to respond to several medications, alien limb syndrome markedly improved with amantadine.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first report of a consistent response of severe, forced dystonic alien limb syndrome to amantadine in a patient with CBS.
authors.affiliation: Neurology Division, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors.forename: Francisco de Assis Aquino
authors.initials: Fde A
authors.lastname: Gondim
authors.affiliation: Neurology Division, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors.forename: José Wagner Leonel
authors.initials: JW
authors.lastname: Tavares Júnior
authors.affiliation: Neurology Division, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors.forename: Arlindo A
authors.initials: AA
authors.lastname: Morais
authors.affiliation: Neurology Division, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors.forename: Paulo Marcelo Gondim
authors.initials: PM
authors.lastname: Sales
authors.affiliation: Neurology Division, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors.forename: Horta Goes
authors.initials: HG
authors.lastname: Wagner
keywords: Alien hand syndrome; amantadine; corticobasal; syndrome