title: Comparison of right and left ventricular function and size in Duchenne muscular dystrophy.
abstract: BACKGROUND
  Right ventricular (RV) size and function in Duchenne muscular dystrophy (DMD) have not been well described. Using cardiac magnetic resonance (CMR) imaging we describe the relationship of RV and left ventricular (LV) size and function in a large DMD cohort.
  
  
  METHODS
  Latest CMR scans of 272 patients consecutively seen at a single tertiary referral center (2011-2014) with skeletal muscle biopsy confirmed DMD were included. 1.5 and 3 Tesla CMR scanners were used. Biventricular ejection fraction (EF), end-diastolic volume index (EDVI), mass and mass index were compared across categories of LVEF.
  
  
  RESULTS
  Mean age was 13.5 ± 4.9 years. 71% had normal (≥ 55%) LVEF while mild (EF 45-54%), moderate (EF 30-44%), and severe LV dysfunction (EF <30%) was present in 20%, 6% and 3% respectively. The correlation between RVEF and LVEF was weak. Even in patients with severe LV dysfunction, RVEF (49.7% ± 12.9%) was relatively preserved. There were no significant differences in RVEDVI and RV mass index across categories of LV function.
  
  
  CONCLUSIONS
  In a large DMD cohort, RVEF was relatively preserved and RV size was preserved across categories of LV dysfunction.
authors.affiliation: Wright State University, Boonshoft School of Medicine, Dayton, OH, USA.
authors.forename: Muddassir
authors.initials: M
authors.lastname: Mehmood
authors.affiliation: Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Kan N
authors.initials: KN
authors.lastname: Hor
authors.affiliation: FAHA, Duke University School of Medicine, Durham, NC, USA.
authors.forename: Hussein R
authors.initials: HR
authors.lastname: Al-Khalidi
authors.affiliation: Children's Hospital of Wisconsin, Milwaukee, WI, USA.
authors.forename: D Woodrow
authors.initials: DW
authors.lastname: Benson
authors.affiliation: MPH, FAAP, FACC, Cincinnati Children's Hospital, Cincinnati, OH, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Jefferies
authors.affiliation: Cincinnati Children's Hospital, Cincinnati, OH, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
authors.affiliation: FACC, The Heart and Vascular Center at the Christ Hospital, Cincinnati, OH, USA.
authors.forename: Gregory F
authors.initials: GF
authors.lastname: Egnaczyk
authors.affiliation: Ohio State University, Columbus, OH, USA.
authors.forename: Subha V
authors.initials: SV
authors.lastname: Raman
authors.affiliation: Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Sanmit K
authors.initials: SK
authors.lastname: Basu
authors.affiliation: Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Linda H
authors.initials: LH
authors.lastname: Cripe
authors.affiliation: RDCS, RDMS, RT (R) Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Germann
authors.affiliation: FACC, The Heart and Vascular Center at the Christ Hospital, Cincinnati, OH, USA. Electronic address: mazurw@ohioheart.org.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Mazur
mesh_terms: D000293:Adolescent; D000328:Adult; D002306:Cardiac Volume / Q000502:physiology; D002648:Child; D015331:Cohort Studies; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*; D055815:Young Adult
keywords: Duchenne Muscular Dystrophy; Left Ventricular Dysfunction; Magnetic Resonance Imaging; Right Ventricular Dysfunction; Right ventricle