title: Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
abstract: There are two types of adipose tissue with distinct functions-white adipose tissue stores chemical energy as triglycerides, whereas brown adipose tissue consumes energy and releases heat (thermogenesis) in response to sympathetic nerve activity. In humans, treatments that promote greater brown adipose tissue deposition and/or activity would be highly beneficial in regimes aimed at reducing obesity. Adult humans have restricted populations of prototypical brown adipocytes in the neck and chest areas, but recent advances have established that adipocytes with similar properties, termed "brite" adipocytes, can be recruited in subcutaneous depots thought to be primarily white adipose tissue. These brite adipocytes express the protein machinery required for thermogenesis, but to assess brite adipocytes as viable therapeutic targets we need to understand how to promote conversion of white adipocytes to brite adipocytes and ways to increase optimal energy consumption and thermogenesis in these brite adipocytes. This can be accomplished by pharmacological and nutritional therapies to differing degrees, as reviewed in detail here.
authors.affiliation: Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
authors.forename: Jon
authors.initials: J
authors.lastname: Merlin
authors.affiliation: Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
authors.forename: Bronwyn A
authors.initials: BA
authors.lastname: Evans
authors.affiliation: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
authors.forename: Nodi
authors.initials: N
authors.lastname: Dehvari
authors.affiliation: Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.|Department of Pharmacology, Monash University, Clayton, Australia.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sato
authors.affiliation: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
authors.forename: Tore
authors.initials: T
authors.lastname: Bengtsson
authors.affiliation: Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.|Department of Pharmacology, Monash University, Clayton, Australia.
authors.forename: Dana S
authors.initials: DS
authors.lastname: Hutchinson
mesh_terms: D017667:Adipocytes / Q000166:cytology; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000502:physiology; D052436:Adipose Tissue, White / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004032:Diet; D006801:Humans; D023421:Models, Animal; D009765:Obesity / Q000178:diet therapy* / Q000188:drug therapy* / Q000517:prevention & control; D022722:Thermogenesis / Q000187:drug effects* / Q000502:physiology*
keywords: Brown adipose tissue; Thermogenesis; UCP1; White adipose tissue