title: LIN28: roles and regulation in development and beyond.
abstract: LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via regulation of the microRNA let-7. However, recent studies have uncovered new roles for LIN28 and have revealed how it functions, suggesting that it is more than just a regulator of miRNA biogenesis. Together, these findings imply a new paradigm for LIN28 - as a gatekeeper molecule that regulates the transition between pluripotency and committed cell lineages, in both let-7-dependent and let-7-independent manners. Here, we provide an overview of LIN28 function in development and disease.
authors.affiliation: Department of Molecular Biology, Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA tsialije@rowan.edu.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Tsialikas
authors.affiliation: Department of Molecular Biology, Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Romer-Seibert
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D004331:Drosophila melanogaster / Q000378:metabolism; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000166:cytology; D011487:Protein Conformation; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012038:Regeneration
chemical_list: C000715187:Lin28A protein, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins; C487931:mirnlet7 microRNA, human
keywords: LIN-28; Pluripotency; RNA-binding protein