title: A hitherto unrecognised case of progressive multifocal leukoencephalopathy.
abstract: A 65-year-old man presented with a 6-week history of increasing confusion with associated cognitive decline. Empirical antibiotic cover for a urinary tract infection was prescribed with no response. After exhaustive radiological and pathological investigations were carried out, a diagnosis of John Cunningham virus encephalopathy was made. This case report describes the varied clinical presentation of symptoms and their management options, along with the latest clinical opinions behind them.
authors.affiliation: Department of Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.
authors.forename: Huey Kuan
authors.initials: HK
authors.lastname: Tan
authors.affiliation: Department of Trauma and Orthopaedics, Nottingham University Hospitals NHS Trust, Nottingham, UK.
authors.forename: Chun Hong
authors.initials: CH
authors.lastname: Tang
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000821:virology; D003221:Confusion / Q000821:virology; D003937:Diagnosis, Differential; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis*; D008297:Male