title: A new potent immunosuppressive isoflavanonol from Campylotropis hirtella.
abstract: Four new flavonoids were isolated from Campylotropis hirtella and these are a chromone and a 2H-chromene, an isoflavone and an isoflavanonol. The structures of these compounds were elucidated by extensive spectroscopic measurements. All of the compounds were assessed for immunosuppressive activity. Compound 4 showed very strong T lymphocyte suppression activity (IC50: 0.13 μM) and potent B lymphocyte suppression activity (IC50: 0.26 μM). Due to its potent immunosuppressive activity and lower cytotoxicity, further structure-activity studies will be pursued on this compound.
authors.affiliation: a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai , China.
authors.forename: Bixia
authors.initials: B
authors.lastname: Xuan
authors.affiliation: a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai , China.
authors.forename: Xing
authors.initials: X
authors.lastname: Du
authors.affiliation: a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai , China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Li
authors.affiliation: a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai , China.|b School of Medicine , Shanghai Jiao Tong University , Shanghai , China.
authors.forename: Zhengwu
authors.initials: Z
authors.lastname: Shen
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000493:pharmacokinetics*; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
chemical_list: D002867:Chromones; D005419:Flavonoids; D007166:Immunosuppressive Agents; D007529:Isoflavones; C000619291:hirtellanine N
keywords: Campylotropis hirtella; immunosuppression; isoflavanoid