title: Assessment of left atrial volume and function in patients with psoriasis by using real time three-dimensional echocardiography.
abstract: BACKGROUND
  Left atrial (LA) volume has been identified as a predictor of adverse cardiovascular outcomes, both in the general population and in selected clinical conditions. The aim of this study was to evaluate the effect of psoriasis on LA volume and mechanical function.
  
  
  METHODS
  A total of 40 consecutive normotensive psoriasis patients free of any cardiovascular disease and 39 healthy volunteers were included. All participants underwent comprehensive transthoracic echocardiographic examination. LA volume and mechanical function were evaluated using real-time three-dimensional echocardiography (RT3DE).
  
  
  RESULTS
  There were no significant differences between psoriasis and control groups with regard to conventional echocardiographic parameters. Individuals with psoriasis had a higher incidence of left ventricular diastolic dysfunction (LVDD) than the controls; nine people with psoriasis (23%) and three control individuals (8%) had LVDD (p = 0.06). With regard to the parameters obtained from RT3DE, LA maximum, LA minimum, passive stroke volume, and passive emptying fraction were significantly higher; whereas LA active emptying fraction, LA total emptying fraction, LA expansion index, and active stroke volume values were significantly lower in individuals with psoriasis compared with controls. Disease duration and Psoriasis Area of Severity Index (PASI) score correlated with the majority of volume parameters.
  
  
  CONCLUSIONS
  Individuals with psoriasis had higher LA phasic volumes and impaired LA mechanical function compared with healthy controls. LA volume and functional analysis with RT3DE may facilitate recognition of subtle LA dysfunction in patients with psoriasis.
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Istanbul, Turkey. dratashalil@gmail.com.
authors.forename: Halil
authors.initials: H
authors.lastname: Atas
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Istanbul, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Kepez
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bozbay
authors.affiliation: Department of Dermatology, Marmara University Training and Research Hospital, Istanbul, Turkey.
authors.forename: Dilek Seckin
authors.initials: DS
authors.lastname: Gencosmanoglu
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Istanbul, Turkey.
authors.forename: Altug
authors.initials: A
authors.lastname: Cincin
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sunbul
authors.affiliation: Faculty of Medicine Hospital, Department of Dermatology, Fatih University, Istanbul, Turkey.
authors.forename: Ayfer Yildiz
authors.initials: AY
authors.lastname: Bozbay
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ramila
authors.initials: R
authors.lastname: Darvishova
authors.affiliation: Department of Dermatology, Marmara University Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tulin
authors.initials: T
authors.lastname: Ergun
mesh_terms: D000328:Adult; D016275:Atrial Function; D003199:Computer Systems; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009929:Organ Size; D011565:Psoriasis / Q000150:complications* / Q000000981:diagnostic imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*
keywords: Left atrial contractility; Left atrial mechanical function; Left atrial volume; Psoriasis; Real-time three-dimensional echocardiography