title: Salivary Gland Epithelial-Myoepithelial Carcinoma with High-Grade Transformation in a Dog.
abstract: An 8-year-old male neutered standard dachshund was presented with a slowly growing mass in the left submandibular salivary gland. Histopathological examination revealed a tumour that was composed of bilayered duct-like structures with an inner layer of ductal cells and an outer layer of clear cells. Both inner and outer cells in the greater part of the tumour exhibited low to moderate atypia and low mitotic activity. However, a focal area towards the periphery showed enhanced cellular atypia and mitotic activity in tumour cells. Immunohistochemically, the outer layer of clear cells expressed myoepithelial markers, while the inner layer cells were positive for a luminal epithelial marker. No local recurrence or lymph node or distant metastasis was observed 18 months following surgery. Based on the morphology and immunohistochemical findings, a final diagnosis of epithelial-myoepithelial carcinoma with high-grade transformation was made.
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Tokyo, Japan.
authors.forename: T E
authors.initials: TE
authors.lastname: Kishimoto
authors.affiliation: Division of Physiological Pathology, Department of Applied Science, School of Veterinary Nursing and Technology, Tokyo, Japan. Electronic address: yoshimura-h@nvlu.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Yoshimura
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Michishita
authors.affiliation: Department of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kanno
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohkusu-Tsukada
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D009208:Myoepithelioma / Q000473:pathology / Q000662:veterinary*; D060787:Neoplasm Grading; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology / Q000662:veterinary*; D013365:Submandibular Gland Neoplasms / Q000473:pathology / Q000662:veterinary*
keywords: dog; epithelial–myoepithelial carcinoma; salivary gland; tumour