title: Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies.
abstract: In this final portion of an extensive review of heart valve engineering, we focus on the computational methods and experimental studies related to heart valves. The discussion begins with a thorough review of computational modeling and the governing equations of fluid and structural interaction. We then move onto multiscale and disease specific modeling. Finally, advanced methods related to in vitro testing of the heart valves are reviewed. This section of the review series is intended to illustrate application of computational methods and experimental studies and their interrelation for studying heart valves.
authors.affiliation: Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA. arashkh@uci.edu.|Department of Medicine, Division of Cardiology, University of California, Irvine School of Medicine, Irvine, CA, USA. arashkh@uci.edu.
authors.forename: Arash
authors.initials: A
authors.lastname: Kheradvar
authors.affiliation: Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA.|Department of Medicine, Division of Cardiology, University of California, Irvine School of Medicine, Irvine, CA, USA.
authors.forename: Elliott M
authors.initials: EM
authors.lastname: Groves
authors.affiliation: Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Falahatpisheh
authors.affiliation: Department of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA, USA.
authors.forename: Mohammad K
authors.initials: MK
authors.lastname: Mofrad
authors.affiliation: Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hamed Alavi
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Tranquillo
authors.affiliation: Department of Mechanical Engineering, School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.
authors.forename: Lakshmi P
authors.initials: LP
authors.lastname: Dasi
authors.affiliation: Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, ON, Canada.|Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Simmons
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX, USA.
authors.forename: K
authors.initials: K
authors.lastname: Jane Grande-Allen
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Goergen
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: Baaijens
authors.affiliation: Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Little
authors.affiliation: Department of Mathematics, University of Houston, Houston, TX, USA.
authors.forename: Suncica
authors.initials: S
authors.lastname: Canic
authors.affiliation: Department of Mathematics, Center for Interdisciplinary Applied Mathematics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.|McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
authors.forename: Boyce
authors.initials: B
authors.lastname: Griffith
mesh_terms: D003198:Computer Simulation; D005260:Female; D006349:Heart Valve Diseases / Q000503:physiopathology* / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular
keywords: Biaxial testing; Computational modeling; Heart valves; Multiscale modeling; Numerical simulation; Particle image velocimetry