title: Impact of soil characteristics on relative bioavailability of NDL-PCBs in piglets.
abstract: Children may be orally exposed to organic pollutants through involuntary soil ingestion. This study was aimed at determining the impact of the characteristics (organic carbon (OC), black carbon (BC), clay contents and pH) of ten contaminated soils on the bioavailability of non-dioxin-like polychlorobiphenyls (NDL-PCBs). Five juvenile male piglets were exposed to increasing amounts of each of the soils. These soil-fed groups were compared by a relative bioavailability approach (RBA) to a reference group fed with corn oil spiked with increasing doses of Aroclor 1254. After 10days of oral exposure, the animals were sacrificed and NDL-PCB concentrations were determined by GC-MS in the adipose tissue. The relative bioavailability (RBA) factors were calculated for PCB 101, 138, 153 and 180. Despite high variations in the amount of black carbon (0.50gkg(-1)-6.0gkg(-1)d.w.) and organic matter (12gkg(-1)-180gkg(-1)d.w.), only 3 soils exhibited a significantly lower RBA for all NDL-PCBs, compared to the oil-group. High levels of OC (>100gkg(-1)) and BC content (3.0gkg(-1)) were related to a significant reduction in RBA. Overall, RBA was higher than 45% independently of the soil and the PCB congener.
authors.affiliation: Université de Lorraine, INRA USC 340, UR AFPA, 2 avenue de la Forêt de Haye TSA 40602, 54 518 Vandœuvre-lès-Nancy, France. Electronic address: matthieu.delannoy@univ-lorraine.fr.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Delannoy
authors.affiliation: Université de Lorraine, INRA USC 340, UR AFPA, 2 avenue de la Forêt de Haye TSA 40602, 54 518 Vandœuvre-lès-Nancy, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Fournier
authors.affiliation: Université Abdou Moumouni de Niamey, Département Sciences du sol, Faculté d'agronomie, BP 10960 Niamey, Niger.
authors.forename: Abdourahamane
authors.initials: A
authors.lastname: Tankari Dan-Badjo
authors.affiliation: Université de Lorraine, INRA USC 340, UR AFPA, 2 avenue de la Forêt de Haye TSA 40602, 54 518 Vandœuvre-lès-Nancy, France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Schwarz
authors.affiliation: Université de Lorraine, INRA USC 340, UR AFPA, 2 avenue de la Forêt de Haye TSA 40602, 54 518 Vandœuvre-lès-Nancy, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lerch
authors.affiliation: Université de Lorraine, INRA USC 340, UR AFPA, 2 avenue de la Forêt de Haye TSA 40602, 54 518 Vandœuvre-lès-Nancy, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Rychen
authors.affiliation: Université de Lorraine, INRA USC 340, UR AFPA, 2 avenue de la Forêt de Haye TSA 40602, 54 518 Vandœuvre-lès-Nancy, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Feidt
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000538:Aluminum Silicates / Q000032:analysis; D000818:Animals; D001682:Biological Availability; D000077215:Clay; D004305:Dose-Response Relationship, Drug; D004435:Eating; D008401:Gas Chromatography-Mass Spectrometry; D006863:Hydrogen-Ion Concentration; D008297:Male; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics*; D012987:Soil / Q000737:chemistry*; D012989:Soil Pollutants / Q000493:pharmacokinetics*; D053260:Soot / Q000032:analysis; D013552:Swine
chemical_list: D000538:Aluminum Silicates; D012987:Soil; D012989:Soil Pollutants; D053260:Soot; D011078:Polychlorinated Biphenyls; D000077215:Clay
keywords: Bioavailability; Children; Ingestion; Pollutant; Polychlorobiphenils; Soil