title: Endocrine Effects of Circadian Disruption.
abstract: Disruption of circadian rhythms, provoked by artificial lighting at night, inconsistent sleep-wake schedules, and transmeridian air travel, is increasingly prevalent in modern society. Desynchrony of biological rhythms from environmental light cycles has dramatic consequences for human health. In particular, disrupting homeostatic oscillations in endocrine tissues and the hormones that these tissues regulate can have cascading effects on physiology and behavior. Accumulating evidence suggests that chronic disruption of circadian organization of endocrine function may lead to metabolic, reproductive, sleep, and mood disorders. This review discusses circadian control of endocrine systems and the consequences of distorting rhythmicity of these systems.
authors.affiliation: Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037.
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Bedrosian
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Fonken
authors.affiliation: Department of Neuroscience and Behavioral Neuroendocrinology Group, The Ohio State University, Columbus, Ohio 43210; email: Randy.Nelson@osumc.edu.
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Nelson
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D004703:Endocrine System / Q000502:physiology*; D006801:Humans; D008029:Lighting / Q000009:adverse effects; D012890:Sleep / Q000502:physiology
keywords: biological rhythms; clock; hormones; light at night; melatonin