title: Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents
abstract: Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.
authors.affiliation: Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, VIC 3168, Melbourne, Australia. chantal.nde@hudson.org.au.
authors.forename: Chantal Beatrice
authors.initials: CB
authors.lastname: Magne Nde
authors.forename: Stephane
authors.initials: S
authors.lastname: Zingue
authors.forename: Evelyn
authors.initials: E
authors.lastname: Winter
authors.forename: Tania Beatriz
authors.initials: TB
authors.lastname: Creczynski-Pasa
authors.forename: Thomas
authors.initials: T
authors.lastname: Michel
authors.forename: Xavier
authors.initials: X
authors.lastname: Fernandez
authors.forename: Dieudonne
authors.initials: D
authors.lastname: Njamen
authors.forename: Colin
authors.initials: C
authors.lastname: Clyne