title: Rapidly-growing squamous cell carcinoma shortly after treatment with ingenol mebutate for actinic keratoses: report of two cases.
abstract: Actinic keratoses (AKs) are defined as cutaneous areas of atypical squamous transformation that are regarded as an early step in the continuum of alterations leading from normal skin to invasive and metastatic squamous cell carcinoma (SCC). AKs are classified as precancerous lesions by some authors and in situ SCC by others. The rate of evolution of a given AK to an invasive SCC has been estimated as 0·075-0·096% per lesion per year. These rates are similar to those estimated for gynaecological intraepithelial neoplasia. We describe two cases of SCC with rapid onset that developed after the application of ingenol mebutate gel for the treatment of AKs.
authors.affiliation: Department of Dermatology, Quirónsalud Hospital General de Catalunya, Barcelona, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Moreno Romero
authors.affiliation: Department of Dermatology, Quirónsalud Hospital General de Catalunya, Barcelona, Spain.|Universitat Internacional de Catalunya, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Campoy
authors.affiliation: Department of Pathology, Quirónsalud Hospital General de Catalunya, Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Perez
authors.affiliation: Department of Pathology, Quirónsalud Hospital Quirón de Barcelona, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Garcia
authors.affiliation: Universitat Internacional de Catalunya, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Grimalt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D003879:Dermatologic Agents / Q000009:adverse effects*; D004224:Diterpenes / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005148:Facial Dermatoses / Q000188:drug therapy; D005153:Facial Neoplasms / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: C486592:3-ingenyl angelate; D003879:Dermatologic Agents; D004224:Diterpenes