title: Effectiveness of Biodegradable Magnesium Alloy Stents in Coronary Artery and Femoral Artery.
abstract: OBJECTIVE
  To access the biocompatibility, effectiveness, and safety of biodegradable magnesium (Mg) alloy stent (BMAS) in the coronary artery and femoral artery.
  
  
  BACKGROUND
  Atherosclerosis is a lesion of cardiovascular system, including the diseases in heart and blood vessels.
  
  
  METHODS
  The aluminum (Al) and zinc (Zn)-based BMAS was designed by cold drawing methods. Forty healthy immunized mongrel dogs were randomly divided into 8 groups. Five dogs who have not been treated with stent were included in control group. The other dogs were implanted with an absorbable magnesium (Mg) alloy in the coronary and/or femoral artery, and their artery angiography were observed at 7 time points (1, 3, 5, 7, 14, 21, and 28 days; n = 5) follow-up. Dogs from each cohort were sacrificed following angiography for pathology assessment. The histological response including inflammatory response, thrombosis, and intimal hyperplasia were analyzed by hematoxylin-eosin staining. Lumen area (La), intimal hyperplasia area (IHa), and the ratio of IHa were calculated by image analysis software.
  
  
  RESULTS
  The thin-walled BMAS were designed and produced by cold-drawing technology. Fifty-one devices were implanted into coronary artery of 35 dogs successfully. During the follow-up days, the angiography of coronary artery and femoral artery had confirmed that the lumen was clear and there were no elastic recoil and thrombosis. The stents were completely disappeared at 7 days after implantation. Moderate intimal hyperplasia was found at 14 days after implantation.
  
  
  CONCLUSIONS
  The BMAS stent proved to be of good biocompatibility, safety, and effectiveness. (J Interven Cardiol 2015;XXXX:XX-XX).
authors.affiliation: Cardiology Department, Peking University Ninth School of Clinical Medicine, Beijing, China.
authors.forename: Yunan
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Cardiology Department, Peking University Ninth School of Clinical Medicine, Beijing, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: Cardiology Department, Peking University Ninth School of Clinical Medicine, Beijing, China.
authors.forename: Nuo
authors.initials: N
authors.lastname: Yang
authors.affiliation: Cardiology Department, Peking University Ninth School of Clinical Medicine, Beijing, China.
authors.forename: Jinglin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Cardiology Department, Peking University Ninth School of Clinical Medicine, Beijing, China.
authors.forename: Licheng
authors.initials: L
authors.lastname: Lei
authors.affiliation: Cardiology Department, Peking University Ninth School of Clinical Medicine, Beijing, China.
authors.forename: Huiming
authors.initials: H
authors.lastname: Ye
authors.affiliation: Cardiology Department, Peking University Ninth School of Clinical Medicine, Beijing, China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Ren
authors.affiliation: Cardiology Department, Peking University Ninth School of Clinical Medicine, Beijing, China.
authors.forename: Shuixiang
authors.initials: S
authors.lastname: Yang
mesh_terms: D020341:Absorbable Implants; D000497:Alloys; D000818:Animals; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000601:surgery*; D004285:Dogs; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D006965:Hyperplasia; D008274:Magnesium; D023421:Models, Animal; D011897:Random Allocation; D015607:Stents; D017539:Tunica Intima / Q000473:pathology
chemical_list: D000497:Alloys; D008274:Magnesium