title: Synthesis of Thrombolytic Sol-Gel Coatings: Toward Drug-Entrapped Vascular Grafts.
abstract: As is evident from numerous investigations, drug-eluting vascular grafts and stents have not solved the main problems associated with thrombosis and due to drug release only postpone their advance for a longer period. Here we point to a potential solution of this problem by developing thrombolytic sol-gel coatings which potentially could lead to drug-entrapped vascular grafts: urokinase-type plasminogen activator was entrapped within a porous alumina sol-gel film with a subsequent deposition on a polymer graft.
authors.affiliation: †Laboratory of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Kronverkskiy Prospekt 49, St. Petersburg, 197101, Russian Federation.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Chapurina
authors.affiliation: †Laboratory of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Kronverkskiy Prospekt 49, St. Petersburg, 197101, Russian Federation.
authors.forename: Vasiliy V
authors.initials: VV
authors.lastname: Vinogradov
authors.affiliation: †Laboratory of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Kronverkskiy Prospekt 49, St. Petersburg, 197101, Russian Federation.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Vinogradov
authors.affiliation: †Laboratory of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Kronverkskiy Prospekt 49, St. Petersburg, 197101, Russian Federation.
authors.forename: Vladimir E
authors.initials: VE
authors.lastname: Sobolev
authors.affiliation: ‡Petrozavodsk State University, Petrozavodsk 185910, Russian Federation.|§Regional Vascular Center, St. Petersburg, Russian Federation.
authors.forename: Ivan P
authors.initials: IP
authors.lastname: Dudanov
authors.affiliation: †Laboratory of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Kronverkskiy Prospekt 49, St. Petersburg, 197101, Russian Federation.
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Vinogradov
mesh_terms: D001807:Blood Vessel Prosthesis; D016503:Drug Delivery Systems; D005782:Gels; D006801:Humans; D008855:Microscopy, Electron, Scanning; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D005782:Gels