title: Organic base-promoted enantioselective electrophilic cyanation of β-keto esters by using chiral phase-transfer catalysts.
abstract: Highly enantioselective cyanation of β-keto esters using hypervalent iodine(iii) as the electrophilic cyanating reagent induced by cinchona alkaloid-based chiral quaternary ammonium salt was demonstrated. Organic bases, especially DMAP, in the chiral phase-transfer catalysis were used to obtain high ees.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. zhengqy@iccas.ac.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Zhi-Tang
authors.initials: ZT
authors.lastname: Huang
authors.forename: Qi-Yu
authors.initials: QY
authors.lastname: Zheng
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D003486:Cyanides / Q000737:chemistry*; D004583:Electrons; D004952:Esters / Q000737:chemistry*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D003486:Cyanides; D004952:Esters