title: Multi-Compartmental Hydrogel Microparticles Fabricated by Combination of Sequential Electrospinning and Photopatterning.
abstract: Multi-compartmental non-spherical hydrogel microparticles were fabricated by combining electrospinning and photopatterning. Sequential electrospinning produced multi-layered fiber matrices with different composition in which each layer became a compartment of the particle. Photopatterning of the hydrogel in the presence of the multi-layered fiber matrix generated multi-compartmental microparticles with different vertical functionalities. While the shapes of the hydrogel microparticles were determined by the design of the photomask, the chemical properties and size of each compartment were independently controlled by changing the molecules incorporated into each fiber matrix and the electrospinning times, respectively. The resultant multi-compartmental hydrogel microparticles could carry out not only the release of different growth factors with independent kinetics but also binding of multiple targets at different compartments.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-gu, Seoul 120-749 (South Korea).
authors.forename: Kanghee
authors.initials: K
authors.lastname: Cho
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-gu, Seoul 120-749 (South Korea).
authors.forename: Hyun Jong
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-gu, Seoul 120-749 (South Korea).
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Han
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-gu, Seoul 120-749 (South Korea).
authors.forename: Ji Hong
authors.initials: JH
authors.lastname: Min
authors.affiliation: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (South Korea).
authors.forename: Hansoo
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-gu, Seoul 120-749 (South Korea). wongun@yonsei.ac.kr.
authors.forename: Won-Gun
authors.initials: WG
authors.lastname: Koh
mesh_terms: D004563:Electrochemistry; D020100:Hydrogels; D008855:Microscopy, Electron, Scanning; D010777:Photochemistry; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D020100:Hydrogels; D011092:Polyethylene Glycols
keywords: drug delivery; electrospun fibers; hydrogels; microparticles; photopatterning