title: Primary Cutaneous Ewing Sarcoma: Report of a Case.
abstract: Primary cutaneous Ewing's sarcoma is a rare entity. Although the diagnosis may be very difficult, it can be confirmed through molecular biology. We present the case of a 13-years old male with a lesion in the sole of the right foot, characterized by a monomorphous proliferation of small, round and blue cells. The histology and molecular biology allowed us to perform the diagnosis of cutaneous Ewing's sarcoma. This neoplasm must be distinguished from other round cell tumors with cutaneous involvement. The prognosis and treatment of this rare disease will also be discussed.
authors.affiliation: a Hospital Universitario Fundación Alcorcon , Pathology , Madrid , Spain.
authors.forename: Veronica
authors.initials: V
authors.lastname: Yuste
authors.affiliation: b Hospital Universitario Infanta Cristina , Pathology , Madrid , Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Sierra
authors.affiliation: c Hospital Infantil Universitario Niño Jesús , Onco-Hematology , Madrid , Spain.
authors.forename: David
authors.initials: D
authors.lastname: Ruano
authors.affiliation: d Hospital Universitario Infanta Cristina , Dermatology , Madrid , Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Llamas-Velasco
authors.affiliation: e Centro Integral Oncológico "Clara Campal", Hospital HM Universitario Sanchinarro , Laboratorio de Dianas Terapéuticas , Madrid , Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Conde
authors.affiliation: c Hospital Infantil Universitario Niño Jesús , Onco-Hematology , Madrid , Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Azorin
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D005528:Foot / Q000473:pathology; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics; D012512:Sarcoma, Ewing / Q000235:genetics / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins
keywords: Ewing's sarcoma; cutaneous; superficial