title: A New Schiff Base Chemodosimeter for Fluorescent Imaging of Ferric Ions in Living Cells.
abstract: A new and efficient chemodosimeter for ferric ions has been developed. The visual and fluorescent behaviors of the compound toward various metal ions were investigated: ferric ions are distinguished from other cations by selective color change and unusual fluorescence enhancement in mixed aqueous solution. Fluorescence microscopy experiments showed that this receptor is effective for detection of Fe(3+) in vitro, developing a good image of the biological organelles. The sensing mechanism is shown to involve a hydrolysis process.
authors.affiliation: Providence University, Taichung City, Taiwan, Republic of China.
authors.forename: Yan-Zi
authors.initials: YZ
authors.lastname: Chen
authors.affiliation: Providence University, Taichung City, Taiwan, Republic of China.
authors.forename: Yeshwant Ramchandra
authors.initials: YR
authors.lastname: Bhorge
authors.affiliation: Providence University, Taichung City, Taiwan, Republic of China.
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Pape
authors.affiliation: Providence University, Taichung City, Taiwan, Republic of China.
authors.forename: Rupesh D
authors.initials: RD
authors.lastname: Divate
authors.affiliation: Providence University, Taichung City, Taiwan, Republic of China.
authors.forename: Yun-Chin
authors.initials: YC
authors.lastname: Chung
authors.affiliation: Providence University, Taichung City, Taiwan, Republic of China. ypyen@pu.edu.tw.
authors.forename: Yao-Pin
authors.initials: YP
authors.lastname: Yen
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D002470:Cell Survival; D005456:Fluorescent Dyes / Q000737:chemistry*; D007501:Iron / Q000032:analysis* / Q000737:chemistry*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D011721:Pyrenes / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry; D000067996:RAW 264.7 Cells; D012545:Schiff Bases / Q000737:chemistry
chemical_list: C570701:2-quinolinecarboxaldehyde; D000447:Aldehydes; D005456:Fluorescent Dyes; D011721:Pyrenes; D011804:Quinolines; D012545:Schiff Bases; C030984:pyrene; D007501:Iron
keywords: Cell imaging; Chemodosimeter; Ferric ion detection; Fluorescence microscopy; Schiff base