title: Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats.
abstract: Quercetin, a flavonoid present in many plants, is reported to be effective in models of neurodegenerative diseases. The aim of the present study was to evaluate the anti-tremor effects of quercetin in 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. In rats, quercetin had no effect on apomorphine-induced rotations, but it could significantly attenuate muscle tremor of 6-OHDA lesioned rats. Interestingly, quercetin could decrease the burst frequency in a dose- and time-dependent manner. These results suggest that quercetin may have a protective effect on models to mimic muscle tremors of Parkinson's disease. This effect of quercetin may be associated with serotonergic system, but further study is needed.
authors.affiliation: a Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Mu
authors.affiliation: b State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Beijing 100191 , China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yuan
authors.affiliation: c The Chinese University of Hong Kong , Hongkong , China.
authors.forename: Li-Da
authors.initials: LD
authors.lastname: Du
authors.affiliation: a Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: He
authors.affiliation: a Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Guan-Hua
authors.initials: GH
authors.lastname: Du
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects; D004195:Disease Models, Animal; D008297:Male; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016627:Oxidopamine / Q000494:pharmacology*; D010300:Parkinson Disease / Q000517:prevention & control; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014202:Tremor / Q000188:drug therapy*
chemical_list: D018696:Neuroprotective Agents; D016627:Oxidopamine; D011794:Quercetin; D001058:Apomorphine
keywords: 6-hydroxydopamine; Parkinson's disease; quercetin; tremor