title: Myelodysplastic syndromes in Chernobyl clean-up workers.
abstract: The studies of the recent decades posed the question of the association between radiation exposure and myelodysplastic syndromes (MDS). This association has been proved in secondary MDS originating upon exposure to chemotherapeutics and/or radiation therapy. The long-term study in Japanese atomic (A)-bomb survivors demonstrated the significant linear dose-response for MDS confirming the link between radiation exposure and this form of hematopoietic malignancies. All these findings provide the strong basis for studying MDS in the persons exposed to radiation following the Chernobyl disaster, especially those in the cohort of Chernobyl clean-up workers of 1986-1987. The data on MDS among Chernobyl clean-up workers (1986-1987) diagnosed in 1996-2012 at the reference laboratory of RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology are summarized. MDS cases were diagnosed in 23 persons (21 males and 2 females) having been exposed to radiation as clean-up workers of 1986-1987. Refractory anemia (RA) has been detected in 13, refractory anemia with ring sideroblasts (RARS)-in 2, and refractory anemia with excess blasts (RAEB)-in 8 patients. The median age of those MDS patients was 62.0 years. In addition, 5 cases of chronic myelomonocytic leukemia (CMML) were recorded in the group of Chernobyl clean-up workers with the median time of 14.8 years from 1986-1987 to diagnosis. The association between radiation exposure and MDS is discussed. The suggested life-long risk for myelodysplastic syndromes among A-bomb survivors in Japan highlights the importance of the continuing follow-up studies in the affected populations in the post-Chernobyl period.
authors.affiliation: RE Kavetsky Institute of Experimental Pathology, Oncology & Radiobiology of the National Academy of Sciences of Ukraine, Vasylkivska 45, 03022, Kyiv, Ukraine, mzavelevych@yahoo.com.
authors.forename: Daniil F
authors.initials: DF
authors.lastname: Gluzman
authors.forename: Lilia M
authors.initials: LM
authors.lastname: Sklyarenko
authors.forename: Stella V
authors.initials: SV
authors.lastname: Koval
authors.forename: Nataliia K
authors.initials: NK
authors.lastname: Rodionova
authors.forename: Michael P
authors.initials: MP
authors.lastname: Zavelevich
authors.forename: Tetiana S
authors.initials: TS
authors.lastname: Ivanivskaya
authors.forename: Liudmyla Yu
authors.initials: LY
authors.lastname: Poludnenko
authors.forename: Nataliia I
authors.initials: NI
authors.lastname: Ukrainskaya
mesh_terms: D000328:Adult; D000368:Aged; D047852:Chernobyl Nuclear Accident; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*