title: The therapeutic effect of Xueshuan Xinmai tablets on memory injury and brain activity in post-stroke patients: a pilot placebo controlled fMRI study.
abstract: OBJECTIVE
  The purpose of this study was to explore the effects of Xueshuan Xinmai tablets (XXMT) for the treatment of cognition, brain activation in the rehabilitation period of ischemic stroke patients.
  
  
  METHODS
  28 adults patients, aged 50-80 years, in the rehabilitation period of ischemic stroke were divided into XXMT treatment group and placebo control group. Patients received 3 months treatment (oral 0.8 g, 3 times per day). Before and after treatment, all patients were evaluated by a series of neuropsychological tests followed by resting-state functional magnetic resonance imaging (fMRI).
  
  
  RESULTS
  In the XXMT treatment group, the patients' episodic memory showed significant improvement. The resting-state fMRI analysis indicated that a significant decline in the fractional amplitude of low-frequency fluctuation value was observed in the bilateral middle cingulate gyrus.
  
  
  CONCLUSIONS
  Yiqi Huoxue effect under XXMT administration has a favorable mediation on episodic memory, consequently suppresses the activation of the cingulate gyrus in the rehabilitation period of ischemic stroke patients.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/Mc Govern Institute for Brain Research, Beijing Normal University Beijing 100875, P. R. China ; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, P. R. China.
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Wei
authors.affiliation: Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences Beijing 100850, P. R. China.
authors.forename: Chenlong
authors.initials: C
authors.lastname: Lv
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/Mc Govern Institute for Brain Research, Beijing Normal University Beijing 100875, P. R. China.
authors.forename: Junying
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, China-Japan Friendship Hospital Beijing 100029, P. R. China.
authors.forename: Dantao
authors.initials: D
authors.lastname: Peng
authors.affiliation: Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences Beijing 100850, P. R. China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/Mc Govern Institute for Brain Research, Beijing Normal University Beijing 100875, P. R. China.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, P. R. China.
authors.forename: Yongyan
authors.initials: Y
authors.lastname: Wang
keywords: Chinese medicinal formula; Episodic memory; brain activation; post-stroke rehabilitation patients; resting-state fMRI