title: Increased Risk of Dementia in Patients With Acute Organophosphate and Carbamate Poisoning: A Nationwide Population-Based Cohort Study.
abstract: Organophosphate (OP) and carbamate (CM) are the most commonly used pesticides against insects. Little is known regarding the relationship between dementia and acute OP and CM poisoning. A nationwide population-based cohort study was conducted from the National Health Insurance Research Database in Taiwan. The incidence and relative risk of dementia were assessed in patients hospitalized for acute OP and CM poisoning from 2000 to 2011. The comparison cohort was matched with the poisoned cohort at a 4:1 ratio based on age, sex, and the year of hospitalization. During the follow-up period, the incidence of dementia was 29.4 per 10,000 person-years in the poisoned group, and represented a 1.98-fold increased risk of dementia compared with the control cohort (95% confidence interval, 1.59-2.47). This study provides evidence on the association between dementia and acute OP and CM poisoning. Regular follow-up of poisoned patients for dementia is suggested.
authors.affiliation: From Department of Critical Care Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan (J-NL); Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan (J-NL, C-HL, H-HL); Department of Nuclear Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan (M-CL); School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan (J-NL); Management Office for Health Data, College of Medicine, I-Shou University, Kaohsiung, Taiwan (C-LL); Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK); Graduate Institute of Clinical Medical Science and School of Medicine, China Medical University, Taichung, Taiwan (C-HK); College of Medicine, China Medical University, Taichung, Taiwan (C-LL); and General Education Center, Meiho University, Pingtung, Taiwan (C-HY).
authors.forename: Jiun-Nong
authors.initials: JN
authors.lastname: Lin
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.forename: Ming-Chia
authors.initials: MC
authors.lastname: Lin
authors.forename: Chung-Hsu
authors.initials: CH
authors.lastname: Lai
authors.forename: Hsi-Hsun
authors.initials: HH
authors.lastname: Lin
authors.forename: Chih-Hui
authors.initials: CH
authors.lastname: Yang
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000328:Adult; D000368:Aged; D002219:Carbamates / Q000506:poisoning*; D015331:Cohort Studies; D003704:Dementia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D015994:Incidence; D007306:Insecticides / Q000506:poisoning*; D007345:Insurance Claim Review / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning; D016016:Proportional Hazards Models; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D002219:Carbamates; D007306:Insecticides