title: Correlation of lipid metabolic disturbance with SOCS-3 gene variation in the Uygur nationality women in Xinjiang.
abstract: To study the correlation of lipid metabolic disturbance with gene variation of suppressor of cytokine signaling 3 (SOCS-3) in the Uygur nationality women in Xinjiang. We Selected 1379 Uygur nationality women as research objects and proceeded genotype assay for 3 representative loci (rs12953258, rs4969168 and rs9914220) to analyze them. There were significant difference in genotypic frequency in rs12953258 between lipid metabolic disturbance group and lipid embolism group (P=0.032) and between high density lipoprotein cholesterol (HDL-C) abnormal and normal group (P=0.029). Logistic regression analysis showed that the AA genotype of rs12953258 might be a risk factors of lipid metabolic disturbance in the Uygur nationality women in Xinjiang [CC/AA: OR=3.271, 95% CI (1.092-9.797), P=0.034]. The AA genotype might be associated with HDL-C decrease and triacylglycerol increase. The AA genotype Uygur nationality women with abnormal body mass index (BMI) were more sensitive to lipid metabolic disturbance disease. SOCS-3 gene variation may be associated with lipid metabolic disturbance in the Uygur nationality women in Xinjiang, prevalence of lipid metabolic disturbance increases significantly in crowd carrying AA genotype with abnormal BMI.
authors.affiliation: The Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang Urumqi, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hong
authors.affiliation: The Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang Urumqi, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: The Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang Urumqi, China.
authors.forename: Niluofeier
authors.initials: N
authors.lastname: Aierken
authors.affiliation: The Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang Urumqi, China.
authors.forename: Dilinigeer
authors.initials: D
authors.lastname: Tuerxun
authors.affiliation: The Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang Urumqi, China.
authors.forename: Mayila
authors.initials: M
authors.lastname: Kamilijiang
authors.affiliation: The Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang Urumqi, China.
authors.forename: Nuerguli
authors.initials: N
authors.lastname: Maimaiti
authors.affiliation: The Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang Urumqi, China.
authors.forename: Gui-Juan
authors.initials: GJ
authors.lastname: Chang
authors.affiliation: The Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang Urumqi, China.
authors.forename: Nan-Fang
authors.initials: NF
authors.lastname: Li
keywords: SOCS-3 gene; leptin; lipid metabolic disorder