title: [Analysis of Musculoskeletal Systems and Their Diseases. Bone metabolism and intercellular network].
abstract: Bone is an active organ under continuous bone remodeling that consists of bone resorption and synthesis. The process requires precise communication among bone cells including osteoclasts, osteoblasts and osteocytes. However, the detailed mechanisms of bone cell interactions have been poorly understood. Technological advances and the accumulating evidence in recent years enabled a better understanding of the communication and coupling mechanisms at the cellular and molecular levels. These studies provide new insights into bone disease pathogenesis and molecular basis for novel therapeutic approaches.
authors.affiliation: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan./Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Terashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takayanagi
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002450:Cell Communication; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D010011:Osteocytes / Q000378:metabolism