title: Risk Factors for Premenopausal Breast Cancer in Bangladesh.
abstract: Background. The incidence of premenopausal breast cancer is rising throughout South Asia. Our objective was to determine the role of risk factors associated with Westernization for premenopausal breast cancer in Bangladesh. Methods. We conducted a matched case-control study between January 1, 2007, and December 31, 2010, at four hospitals in Bangladesh. Cases were premenopausal women diagnosed with invasive breast cancer. Controls were premenopausal women with no personal history of breast cancer. Logistic regression was used to calculate the odds ratios (OR) for breast cancer. Results. We identified 129 age-matched pairs. The mean age of breast cancer diagnosis was 37.5 years. Each year decrease in the age of menarche significantly increased the risk of breast cancer (OR = 1.67, 95% CI 1.09-2.56, P = 0.02). The risk was also increased with a current body mass index of ≥25 kg/m(2) (OR = 5.24, 95% CI 1.10-24.9, P = 0.04). Age at first childbirth, parity, and breastfeeding were not significantly associated with premenopausal breast cancer risk (P > 0.05). Conclusions. Age at menarche and adult weight gain were associated with premenopausal breast cancer risk. Other factors associated with Westernization may not be relevant to premenopausal breast cancer risk in Bangladesh.
authors.affiliation: Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada M5G 1N8.
authors.forename: Javaid
authors.initials: J
authors.lastname: Iqbal
authors.affiliation: Dhaka Medical College Hospital, Dhaka 1000, Bangladesh ; Amader Gram Breast Care Program, Khulna 9000, Bangladesh.
authors.forename: Tahmina
authors.initials: T
authors.lastname: Ferdousy
authors.affiliation: Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh.
authors.forename: Rahela
authors.initials: R
authors.lastname: Dipi
authors.affiliation: Amader Gram Breast Care Program, Khulna 9000, Bangladesh.
authors.forename: Reza
authors.initials: R
authors.lastname: Salim
authors.affiliation: Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada M5G 1N8.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada M5G 1N8 ; Faculty of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada M5T 3M7.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.affiliation: Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada M5G 1N8.
authors.forename: Joanne
authors.initials: J
authors.lastname: Kotsopoulos
authors.affiliation: Anowara Medical Services, Dhaka 1000, Bangladesh.
authors.forename: Mohammad G
authors.initials: MG
authors.lastname: Mostafa
authors.affiliation: Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada M5G 1N8 ; Faculty of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada M5T 3M7.
authors.forename: Ophira
authors.initials: O
authors.lastname: Ginsburg