title: Positive correlation of serum adipocyte fatty acid binding protein levels with carotid-femoral pulse wave velocity in geriatric population.
abstract: BACKGROUND
  Adipocyte fatty acid binding protein (A-FABP) is a novel fat-derived circulating protein, which is independently and positively associated with atherosclerosis. The present study evaluated the relationship between fasting serum A-FABP and central arterial stiffness in geriatric adults.
  
  
  METHODS
  Fasting blood samples were obtained from 87 geriatric patients and the serum A-FABP levels were measured using an enzyme immunoassay. Carotid-femoral pulse wave velocity (cfPWV) was determined using the SphygmoCor system. cfPWV values of >10 m/s represented the high arterial stiffness group, while values ≤10 m/s defined the low arterial stiffness group.
  
  
  RESULTS
  High arterial stiffness group comprised of 42 geriatric adults (48.3%). When compared to those in the low arterial stiffness group, the high arterial stiffness group had a higher rate of diabetes mellitus (P = 0.044) and hypertension (P = 0.043). Body weight (P = 0.027), waist circumference (P = 0.035), body mass index (P = 0.001), systolic blood pressure (P = 0.005), diastolic blood pressure (P = 0.045), pulse pressure (P = 0.038), and serum A-FABP level (P < 0.001) were also higher in the high arterial stiffness group than in the low arterial stiffness group. Multivariate logistic regression analysis of the factors significantly associated with arterial stiffness revealed that A-FABP (odds ratio: 1.833, 95% confidence interval 1.123-2.993, P = 0.015) was an independent predictor of arterial stiffness in geriatric adults.
  
  
  CONCLUSIONS
  Serum A-FABP levels constitute a major risk factor in the development of central arterial stiffness in the geriatric population.
authors.affiliation: Division of Nephrology, Buddhist Tzu Chi General Hospital, Dalin Branch, Chia-Yi, Taiwan. abi0918@outlook.com.|School of Medicine, Tzu Chi University, Hualien, Taiwan. abi0918@outlook.com.
authors.forename: Jen-Pi
authors.initials: JP
authors.lastname: Tsai
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan. jihung-wang@tzuchi.com.tw.|Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. jihung-wang@tzuchi.com.tw.
authors.forename: Ji-Hung
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Department of Nursing, Tzu Chi College of Technology, Hualien, Taiwan. guggilee@msn.com.
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. michaelchen@tzuchi.com.tw.
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Chen
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan. gee.lily@msa.hinet.net.|Division of Nephrology, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung-Yang Road, Hualien, 97002, Taiwan. gee.lily@msa.hinet.net.
authors.forename: Bang-Gee
authors.initials: BG
authors.lastname: Hsu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D050197:Atherosclerosis / Q000097:blood / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002339:Carotid Arteries / Q000503:physiopathology; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D006801:Humans; D008297:Male; D063177:Pulse Wave Analysis / Q000379:methods*; D012307:Risk Factors; D013223:Statistics as Topic; D059289:Vascular Stiffness / Q000502:physiology
chemical_list: D050556:Fatty Acid-Binding Proteins