title: Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases.
abstract: Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lymphoid cells (ILCs), which are mainly localize to epithelial surfaces, have been characterized as regulators of chronic inflammation and tissue remodeling, representing a functional bridge between the innate and adaptive immunity. Moreover, recent research has implicated ILCs as potential contributing factors to several kinds of fibrosis diseases, such as hepatic fibrosis and pulmonary fibrosis. Here, we will summarize and discuss the key roles of ILCs and their related factors in fibrotic diseases and their potential for translation to the clinic.
authors.affiliation: a Institute of Immunology, PLA, Third Military Medical University , Chongqing , PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: b Department of Dermatology , 105th Hospital of PLA , Hefei , PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
authors.affiliation: a Institute of Immunology, PLA, Third Military Medical University , Chongqing , PR China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Tian
authors.affiliation: c Van Velkinburgh Initiative for Collaboratory BioMedical Research , Santa Fe , NM , USA.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: van Velkinburgh
authors.affiliation: d Department of Microbiology and Immunology , The Pennsylvania State University College of Medicine , Hershey , PA , USA.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Song
authors.affiliation: a Institute of Immunology, PLA, Third Military Medical University , Chongqing , PR China.
authors.forename: Yuzhang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: a Institute of Immunology, PLA, Third Military Medical University , Chongqing , PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Ni
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D005355:Fibrosis; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D007249:Inflammation / Q000276:immunology*; D008099:Liver / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology*; D011658:Pulmonary Fibrosis / Q000276:immunology*
keywords: chronic inflammation; fibrosis; hepatic fibrosis; innate lymphoid cells; interleukin; pulmonary fibrosis