title: Organic-Inorganic Composites Toward Biomaterial Application.
abstract: Bioactive ceramics are known to exhibit specific biological affinities and are able to show direct integration with surrounding bone when implanted in bony defects. However, their inadequate mechanical properties, such as low fracture toughness and high Young's modulus in comparison to natural bone, limit their clinical application. Bone is a kind of organic-inorganic composite where apatite nanocrystals are precipitated onto collagen fibre networks. Thus, one way to address these problems is to mimic the natural composition of bone by using bioactive ceramics via material designs based on organic-inorganic composites. In this chapter, the current research on the development of the various organic-inorganic composites designed for biomaterial applications has been reviewed. Various compounds such as calcium phosphate, calcium sulphate and calcium carbonate can be used for the inorganic phases to design composites with the desired mechanical and biological properties of bone. Not only classical mechanical mixing but also coating of the inorganic phase in aqueous conditions is available for the fabrication of such composites. Organic modifications using various polymers enable the control of the crystalline structure of the calcium carbonate in the composites. These approaches on the fabrication of organic-inorganic composites provide important options for biomedical materials with novel functions.
authors.affiliation: Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Ayae
authors.initials: A
authors.lastname: Sugawara-Narutaki
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohtsuki
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry; D018786:Bone Substitutes / Q000737:chemistry*; D002119:Calcium Carbonate / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D002133:Calcium Sulfate / Q000737:chemistry; D002516:Ceramics / Q000737:chemistry*; D006801:Humans
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C020243:calcium phosphate; D002119:Calcium Carbonate; D002133:Calcium Sulfate