title: Fibroblast growth factor signaling in skeletal development and disease.
abstract: Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating chondrogenesis, osteogenesis, and bone and mineral homeostasis. This review updates our review on FGFs in skeletal development published in Genes & Development in 2002, examines progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis, and explores the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans. Links between FGF signaling pathways and other interacting pathways that are critical for skeletal development and could be exploited to treat genetic diseases and repair bone are also explored.
authors.affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA;
authors.forename: David M
authors.initials: DM
authors.lastname: Ornitz
authors.affiliation: UMR-1132, Institut National de la Santé et de la Recherche Médicale, Hopital Lariboisiere, 75475 Paris Cedex 10, France; Université Paris Diderot, Sorbonne Paris Cité, 75475 Paris Cedex 10, France.
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: Marie
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000235:genetics* / Q000628:therapy; D001861:Bone Regeneration / Q000235:genetics; D001842:Bone and Bones / Q000196:embryology* / Q000503:physiopathology*; D020219:Chondrogenesis; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008903:Minerals / Q000378:metabolism; D009154:Mutation; D010012:Osteogenesis; D015398:Signal Transduction
chemical_list: D008903:Minerals; D005346:Fibroblast Growth Factors
keywords: FGF; FGFR; bone; cartilage; chondrocyte; osteoblast