title: Total Pancreatectomy With Islet Cell Transplantation for the Treatment of Pancreatic Cancer.
abstract: Resection or removal of the pancreas causes loss of parenchyma, which can result in extreme disruption of glucose homeostasis and malabsorption of dietary nutrients. However, islet autotransplantation (IAT) may reduce or prevent the severity of pancreatogenic diabetes. This article explores total pancreatectomy with IAT within the context of pancreatic cancer treatment. At a Glance • The liver is the preferred site for implantation because of easy vascular access. • Following islet autotransplantation, the liver becomes an insulin-producing organ as the transplanted beta cells begin making insulin. • The most significant complication of implantation in the liver is portal vein occlusion because of thrombosis; consequently, a heparin drip is infused for the first seven days postoperatively to prevent portal vein thrombus formation.
authors.affiliation: Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute in Columbus.
authors.forename: Lisa
authors.initials: L
authors.lastname: Parks
authors.affiliation: Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute in Columbus.
authors.forename: Meghan
authors.initials: M
authors.lastname: Routt
mesh_terms: D006801:Humans; D016381:Islets of Langerhans Transplantation; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000451:nursing / Q000601:surgery*
keywords: islet cell transplantation; pancreatectomy; pancreatogenic diabetes