title: Evaluation of bone mass in children and young adults with juvenile idiopathic arthritis.
abstract: OBJECTIVE
  To examine bone mineral density (BMD) in the spines of patients with juvenile idiopathic arthritis (JIA), and to identify the main predictors of spine BMD.
  
  
  METHODS
  160 patients with JIA (82 female, 78 male; median age, 8.7±3.9 years (range, 2.2-18.2 years)) who fulfilled the International League of Associations for Rheumatology (ILAR) criteria were enrolled. All subjects underwent an initial dual energy x-ray absorptiometry (DXA) scan of the lumbar spine, while 114 and 87 patients underwent a second and third scan, respectively. The data were compared with those obtained for 114 sex- and age-matched healthy controls.
  
  
  RESULTS
  The DXA scans revealed that the JIA patients had a significant spine BMD deficit compared with control subjects (p<0.001). Longitudinal comparison of patients revealed no significant short-term improvement in the spine BMD. Spine BMD correlated with the age (p<0.05), subtype (p<0.05), and disease activity (p<0.01), BMI (p=0.001), glucocorticoid (GC) exposure (p< 0.05), methotrexate (MTX) therapy (p<0.05), and non-steroidal anti-inflammatory agents (NSAIDs) (p<0.05), erythrocyte sedimentation rate (ESR) (p<0.01), and C-reactive protein (CRP) levels (p<0.01).
  
  
  CONCLUSIONS
  Patients with JIA have low bone mass, especially those in the polyarticular group >7 years old with higher disease activity.
authors.affiliation: Department of Nephrology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Tang
authors.affiliation: Department of Nephrology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Nephrology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Nephrology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Yingbo
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Nephrology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Department of Nephrology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Li
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000367:Age Factors; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000000981:diagnostic imaging* / Q000188:drug therapy; D015519:Bone Density; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013131:Spine / Q000000981:diagnostic imaging*
chemical_list: D018501:Antirheumatic Agents