title: Promiscuity of autoimmune responses to MBP after stroke.
abstract: In this study we examined Th1 and Th17 immune responses to rat myelin basic protein (MBP), bovine MBP, human MBP, MBP 68-86, MBP 63-81 and ovalbumin in Lewis rats to determine which MBP antigen is recognized following ischemic brain injury. Responses were compared to animals immunized to rat MBP. Data show that immune responses following immunization with rat MBP are promiscuous with cross reaction to MBP from other species. After stroke, few animals develop Th1 or Th17 responses to MBP, but when those responses occur, especially Th1 responses to rat MBP in the brain, they are predictive of worse stroke outcome.
authors.affiliation: University of Washington School of Medicine, Department of Neurology, Seattle, WA, United States.
authors.forename: Dannielle
authors.initials: D
authors.lastname: Zierath
authors.affiliation: University of Washington School of Medicine, Department of Neurology, Seattle, WA, United States.
authors.forename: Allison
authors.initials: A
authors.lastname: Kunze
authors.affiliation: University of Washington School of Medicine, Department of Neurology, Seattle, WA, United States.
authors.forename: Leia
authors.initials: L
authors.lastname: Fecteau
authors.affiliation: University of Washington School of Medicine, Department of Neurology, Seattle, WA, United States. Electronic address: kjb@uw.edu.
authors.forename: Kyra
authors.initials: K
authors.lastname: Becker
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000187:drug effects / Q000276:immunology*; D001921:Brain / Q000187:drug effects / Q000276:immunology; D002417:Cattle; D006801:Humans; D004676:Myelin Basic Protein / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D020521:Stroke / Q000188:drug therapy* / Q000276:immunology*; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: C436006:Mbp protein, rat; D004676:Myelin Basic Protein
keywords: Immune response; MBP; Stroke; Th1; Th17