title: Adiposity and cancer risk: new mechanistic insights from epidemiology.
abstract: Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for many common adult cancers. Over the past decade, epidemiological data have shown that adiposity-cancer risk associations are specific for gender, site, geographical population, histological subtype and molecular phenotype. The biological mechanisms underpinning these associations are incompletely understood but need to take account of the specificities observed in epidemiology to better inform future prevention strategies.
authors.affiliation: Institute of Cancer Sciences, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Renehan
authors.affiliation: Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, Bern CH-3012, Switzerland.
authors.forename: Marcel
authors.initials: M
authors.lastname: Zwahlen
authors.affiliation: Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, Bern CH-3012, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Egger
mesh_terms: D050154:Adiposity; D000818:Animals; D015992:Body Mass Index; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D009765:Obesity / Q000150:complications* / Q000473:pathology; D012307:Risk Factors