title: Does Age at Operation Influence the Short- and Long-Term Outcomes of Off-Pump Coronary Artery Bypass Grafting?
abstract: BACKGROUND
  To investigate the relationship between age and both short- and long-term outcomes of off-pump coronary bypass grafting (OPCAB).
  
  
  RESULTS
  The 780 patients undergoing OPCAB were divided into 3 groups: 262 aged <65 years (young), 329 aged 65-74 years (early elderly), and 189 aged >75 years (late elderly), and retrospectively analyzed. The follow-up rate was 94.9%, and mean follow-up period was 5.6±3.4 years. In-hospital mortality rates were similar among the groups (0.8% in young, 1.2% in early elderly, and 1.1% in late elderly; P=0.862). In logistic regression analysis, the risk factor for predicting major complications was the New York Heart Association (NYHA) classification (odds ratio: 1.555, P=0.001), and not age. The 10-year estimated rates free from cardiac death (89.6±3.2, 95.0±2.1, and 96.5±2.1%, log rank, P=0.16) and cardiac events (71.8±3.8, 66.8±4.3, and 59.9±7.7%, P=0.61) were not significantly different among the groups. In multivariate Cox models, independent risk factors predicting cardiac events were the NYHA classification (hazard ratio (HR): 1.265, P=0.009), and ejection fraction (HR: 0.986, P=0.016), but not age (young HR: 1.0, early elderly HR: 1.276; P=0.210, late elderly HR: 0.910; P=0.707).
  
  
  CONCLUSIONS
  Both short- and long-term cardiac outcomes of OPCAB are not influenced by age at operation.
authors.affiliation: Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine.
authors.forename: Suguru
authors.initials: S
authors.lastname: Ohira
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Doi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Numata
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Tsunehisa
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Megumi
authors.initials: M
authors.lastname: Fukuishi
authors.forename: Akie
authors.initials: A
authors.lastname: Fujita
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yaku
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D047549:Coronary Artery Bypass, Off-Pump / Q000401:mortality*; D003643:Death; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate