title: Characterization of structural-prior guided optical tomography using realistic breast models derived from dual-energy x-ray mammography.
abstract: Multi-spectral near-infrared diffuse optical tomography (DOT) is capable of providing functional tissue assessment that can complement structural mammographic images for more comprehensive breast cancer diagnosis. To take full advantage of the readily available sub-millimeter resolution structural information in a multi-modal imaging setting, an efficient x-ray/optical joint image reconstruction model has been proposed previously to utilize anatomical information from a mammogram as a structural prior. In this work, we develop a complex digital breast phantom (available at http://openjd.sf.net/digibreast) based on direct measurements of fibroglandular tissue volume fractions using dual-energy mammographic imaging of a human breast. We also extend our prior-guided reconstruction algorithm to facilitate the recovery of breast tumors, and perform a series of simulation-based studies to systematically evaluate the impact of lesion sizes and contrasts, tissue background, mesh resolution, inaccurate priors, and regularization parameters, on the recovery of breast tumors using multi-modal DOT/x-ray measurements. Our studies reveal that the optical property estimation error can be reduced by half by utilizing structural priors; the minimum detectable tumor size can also be reduced by half when prior knowledge regarding the tumor location is provided. Moreover, our algorithm is shown to be robust to false priors on tumor location.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Deng
authors.affiliation: BSPIRAL group and ECE Dept., Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.
authors.forename: Dana H
authors.initials: DH
authors.lastname: Brooks
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
authors.affiliation: Philips Healthcare, Smidesvägen 5, 171 41 Solna, Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Lundqvist
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Fang
keywords: (100.3190) Inverse problems; (110.3080) Infrared imaging; (170.3010) Image reconstruction techniques; (170.3830) Mammography; (200.4560) Optical data processing