title: Nanocarriers for delivery of siRNA and co-delivery of siRNA and other therapeutic agents.
abstract: A major problem in cancer treatment is the multidrug resistance. siRNA inhibitors have great advantages to solve the problem, if the bottleneck of their delivery could be well addressed by the various nanocarriers. Moreover, co-delivery of siRNA together with the various anticancer agents in one nanocarrier may maximize their additive or synergistic effect. This review provides a comprehensive summary on the state-of-the-art of the nanocarriers, which may include prodrugs, micelles, liposomes, dendrimers, nanohydrogels, solid lipid nanoparticles, nanoparticles of biodegradable polymers and nucleic acid nanocarriers for delivery of siRNA and co-delivery of siRNA together with anticancer agents with focus on synthesis of the nanocarrier materials, design and characterization, in vitro and in vivo evaluation, and prospect and challenges of nanocarriers.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Chemical & Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore.|International Joint Cancer Institute, Second Military Medical University, Shanghai 200433, China.
authors.forename: Si-Shen
authors.initials: SS
authors.lastname: Feng
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D034741:RNA, Small Interfering
keywords: RNAi therapeutics; biodegradable polymer; cancer nanotechnology; chemotherapy; molecular biomaterials; multidrug resistance; nanotheranostics