title: Simultaneous solvent screening and reaction optimization in microliter slugs.
abstract: An automated, continuous flow droplet screening system is presented, enabling real-time simultaneous solvent and continuous variable optimization. An optimal design of experiments strategy is applied to the alkylation of 1,2-diaminocyclohexane in 16 μL droplets, with scale-up demonstrated. Analysis of segmented flow results suggests correlation of yield with solvent hydrogen bond basicity.
authors.affiliation: Department of Chemical Engineering, Novartis-MIT Center for Continuous Manufacturing, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. kfjensen@mit.edu.
authors.forename: Brandon J
authors.initials: BJ
authors.lastname: Reizman
authors.forename: Klavs F
authors.initials: KF
authors.lastname: Jensen
mesh_terms: D000478:Alkylation; D003514:Cyclohexylamines / Q000138:chemical synthesis; D057166:High-Throughput Screening Assays / Q000379:methods*; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D012107:Research Design; D012997:Solvents
chemical_list: D003514:Cyclohexylamines; D012997:Solvents