title: Serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab.
abstract: Nivolumab, a blockade of programmed cell death 1, is now administrated for advanced malignant melanomas. Nivolumab-associated adverse events include organ-specific autoimmune disorders; autoimmune thyroid disease, vitiligo and insulin-dependent diabetes. However, predisposed persons are currently unknown. Here, we report serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab: one with Hashimoto disease and another with probable subclinical Hashimoto disease. We should verify if nivolumab-related hypothyroidism and hyperthyroidism are predisposed to occur in euthyroid individuals with subclinical autoimmune thyroid disease.
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Narita
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Oiso
authors.affiliation: Department of Endocrinology, Metabolism and Diabetes, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Taketomo
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Okahashi
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Sato
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Shusuke
authors.initials: S
authors.lastname: Uchida
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Matsuda
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kawada
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008297:Male; D008545:Melanoma / Q000556:secondary / Q000628:therapy; D000077594:Nivolumab; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013963:Thyroid Hormones / Q000097:blood; D014463:Ultrasonography
chemical_list: D000911:Antibodies, Monoclonal; D013963:Thyroid Hormones; D000077594:Nivolumab
keywords: Hashimoto disease; insulin-dependent diabetes; malignant melanoma; nivolumab; ultrasonography; vitiligo