title: [Meta-analysis on autogenous fat injection for unilateral vocal cord paralysis].
abstract: OBJECTIVE
  This study conduct a qualitative synthesis and quantitative meta-analysis of VFAFI, aimed to study whether it is a useful treatment for UVCP.
  
  
  METHODS
  Electronic databases PubMed, YZ365. COM, WANFANG DATA, CMJD, CHKD,CNKI were searched using relevant keywords. Reported treatment outcomes were clustered into three categories,i. e. subjective, perceptual,acoustic,aerodynamic,and stroboscopic. Meta-analyses were performed on studies with numerical results using random effects model.
  
  
  RESULTS
  Five articles were identified with a total of 404 patients. All the studies reported significant improvements or decrease after VFAFI in each category of outcome measurements. Meta-analysis demonstrated a significant increase or decrease in all categories. Adverse effects include slight inflammatory reponse can resolve spontaneously within 1 month. The recurrence rate after VFAFI was high due to the self absorption. NNE and Jitter of post-operation is lower than pre-operation,there is no significantly change between the control group and experimental group; F0, Shimmer and MPT of post-operation is higher than pre-operation, there is no significantly change between the control group and experimental group.
  
  
  CONCLUSIONS
  The invasiveness and morbidity of VFAFI are low and the side effects are self-limited. Meta-analyses demonstrated significant improvements or decreased from both objective and subjective measurements. Further controlled studies with longer follow-up periods and more person were included may evaluate the effectiveness of VFAFI more reliably.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Xu
authors.forename: Suoqiang
authors.initials: S
authors.lastname: Zhai
authors.forename: Rongguang
authors.initials: R
authors.lastname: Wang
authors.forename: Shiming
authors.initials: S
authors.lastname: Yang
authors.forename: Dongyan
authors.initials: D
authors.lastname: Huang
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D006801:Humans; D007267:Injections; D016896:Treatment Outcome; D014826:Vocal Cord Paralysis / Q000628:therapy*; D014833:Voice Quality