title: Epidemiology and Inherited Predisposition for Sporadic Pancreatic Adenocarcinoma.
abstract: Given the changing demographics of Western populations, the numbers of pancreatic cancer cases are projected to increase during the next decade. Diabetes, recent cigarette smoking, and excess body weight are the cancer's most consistent risk factors. The search for common and rare germline variants that influence risk of pancreatic cancer through genome-wide association studies and high-throughput-sequencing-based studies is underway and holds the promise of increasing the knowledge of variants and genes that play a role in inherited susceptibility of this disease. Research reported in this review has advanced the understanding of pancreatic cancer.
authors.affiliation: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 6E420, Rockville, MD 20850, USA. Electronic address: rs221z@nih.gov.
authors.forename: Rachael Z
authors.initials: RZ
authors.lastname: Stolzenberg-Solomon
authors.affiliation: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892, USA. Electronic address: amundadottirl@mail.nih.gov.
authors.forename: Laufey T
authors.initials: LT
authors.lastname: Amundadottir
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000235:genetics; D000818:Animals; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D015994:Incidence; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
keywords: Diabetes; Etiology; Genome-wide association studies; Pancreatic cancer