title: Semiconducting Polymer Nanoparticles with Persistent Near-Infrared Luminescence for In Vivo Optical Imaging.
abstract: Materials with persistent luminescence are attractive for in vivo optical imaging since they have a long lifetime that allows the separation of excitation of fluorophores and image acquisition for time-delay imaging, thus eliminating tissue autofluorescence associated with fluorescence imaging. Persistently luminescent nanoparticles have previously been fabricated from toxic rare-earth metals. This work reports that nanoparticles made of the conjugated polymer MEH-PPV can generate luminescence persisting for an hour upon single excitation. A near-infrared dye was encapsulated in the conjugated polymer nanoparticle to successfully generate persistent near-infrared luminescence through resonance energy transfer. This new persistent luminescence nanoparticles have been demonstrated for optical imaging applications in living mice.
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94395-5484 (USA) http://www.raolab.stanford.edu.
authors.forename: Mikael
authors.initials: M
authors.lastname: Palner
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94395-5484 (USA) http://www.raolab.stanford.edu.|Current address: School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459 (Singapore).
authors.forename: Kanyi
authors.initials: K
authors.lastname: Pu
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94395-5484 (USA) http://www.raolab.stanford.edu.
authors.forename: Shirley
authors.initials: S
authors.lastname: Shao
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94395-5484 (USA) http://www.raolab.stanford.edu. jrao@stanford.edu.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Rao
mesh_terms: D000818:Animals; D049449:Luminescence; D051379:Mice; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*; D012666:Semiconductors; D019265:Spectroscopy, Near-Infrared
chemical_list: D011108:Polymers
keywords: MEH-PPV; fluorescence; in vivo imaging; persistent luminescence; polymer nanoparticle