title: Elevated serum creatinine and low albumin are associated with poor outcomes in patients with liposarcoma.
abstract: Low serum albumin levels and impaired kidney function have been associated with decreased survival in patients with a variety of cancer types. In a retrospective cohort study, we analyzed 84 patients with liposarcoma treated at from May 1994 to October 2011. Uni- and multivariable Cox proportional hazard models and competing risk analyses were performed to evaluate the association between putative biomarkers with disease-specific and overall survival. The median age of the study population was 51.7 (range 19.6-83.8) years. In multivariable analysis adjusted for AJCC tumor stage, serum creatinine was highly associated with disease-specific survival (Subdistribution Hazard ratio (SHR) per 1 mg/dl increase = 2.94; 95%CI 1.39-6.23; p = 0.005). High albumin was associated with improved overall and disease-specific survival (Hazard Ratio (HR) per 10 units increase = 0.50; 95%CI 0.26-0.95; p = 0.033 and SHR = 0.64; 95%CI 0.42-1.00; p = 0.049). The serum albumin-creatinine-ratio emerged to be associated with both overall and disease-specific survival after adjusting for AJCC tumor stage (HR = 0.95; 95%CI 0.92-0.99; p = 0.011 and SHR = 0.96; 95%CI 0.93-0.99; p = 0.08). Our study provides evidence for a tumor-stage-independent association between higher creatinine and lower albumin with worse disease-specific survival. Low albumin and a high albumin-creatinine-ratio independently predict poor overall survival. Our work identified novel prognostic biomarkers for prognosis of patients with liposarcoma.
authors.affiliation: Department of Orthopaedics, Medical University of Vienna, Vienna, Austria.
authors.forename: Joannis
authors.initials: J
authors.lastname: Panotopoulos
authors.affiliation: Department of Medicine I, Clinical Division of Haematology and Haemostaseology, Medical University of Vienna, Vienna, Austria.
authors.forename: Florian
authors.initials: F
authors.lastname: Posch
authors.affiliation: Department of Orthopaedics, Medical University of Vienna, Vienna, Austria.
authors.forename: Philipp T
authors.initials: PT
authors.lastname: Funovics
authors.affiliation: Department of Orthopaedics, Medical University of Vienna, Vienna, Austria.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Willegger
authors.affiliation: Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
authors.forename: Anke
authors.initials: A
authors.lastname: Scharrer
authors.affiliation: Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lamm
authors.affiliation: Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brodowicz
authors.affiliation: Department of Orthopaedics, Medical University of Vienna, Vienna, Austria.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Windhager
authors.affiliation: Department of Medicine I, Clinical Division of Haematology and Haemostaseology, Medical University of Vienna, Vienna, Austria.
authors.forename: Cihan
authors.initials: C
authors.lastname: Ay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000378:metabolism*; D001317:Austria / Q000453:epidemiology; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D008080:Liposarcoma / Q000097:blood* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000418:Albumins; D003404:Creatinine
keywords: albumin; creatinine; liposarcoma; prognostic biomarkers