title: Folate-polydiacetylene-liposome for tumor targeted drug delivery and fluorescent tracing.
abstract: A novel folate-polydiacetylene-liposome (FP-PL) with both targeted drug delivery and fluorescence tracing was prepared by thin film rehydration method. The simulated drug delivery was performed in Bcap-37 breast cancer cells and Hs578Bst normal cells in vitro. The internalization and distribution of FP-PLs in the cells were presented by fluorescence cell imaging. The results show that the FP-PLs possess low cytotoxicity, good biocompatibility and better targeting efficiency in comparison to polydiacetylene-liposomes (P-PLs).
authors.affiliation: Department of Chemistry, Institute of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Lielie
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Chemistry, Institute of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China. Electronic address: anxueqin@ecust.edu.cn.
authors.forename: Xueqin
authors.initials: X
authors.lastname: An
authors.affiliation: Department of Chemistry, Institute of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Yan
mesh_terms: D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D008081:Liposomes; D008856:Microscopy, Fluorescence / Q000379:methods*; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry*
chemical_list: D008081:Liposomes; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene; D005492:Folic Acid
keywords: Fluorescent imaging; Folic acid; Liposome; Polydiacetylene; Targeted drug delivery