title: International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events.
abstract: OBJECTIVE
  To determine the accuracy of international warfarin pharmacogenetic algorithms developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict therapeutic warfarin doses in Turkish patients.
  
  
  METHODS
  We investigated two Turkish warfarin-treated cohorts: patients with no history of hemorrhagic or thromboembolic event and patients with major and life-threatening hemorrhagic events.
  
  
  RESULTS
  International pharmacogenetic algorithms showed good performances in predicting the therapeutic dose of patients with no history of bleedings, but they did not significantly detect the incorrect warfarin dose of patients with major and life-threatening hemorrhagic events.
  
  
  CONCLUSIONS
  Although genetic information can predict the therapeutic warfarin dose, the accuracy of the international pharmacogenetic algorithms is not sufficient to be used for warfarin screening in Turkish patients.
authors.affiliation: School of Health Science, Aksaray University, Aksaray, Turkey.|GENAR Institute for Public Health & Genomics Research, Ankara, Turkey.
authors.forename: Sefayet
authors.initials: S
authors.lastname: Karaca
authors.affiliation: Department of Endocrinology & Metabolism, Diskapi Yildirim Beyazit Training & Research Hospital, Ankara, Turkey.
authors.forename: Nujen Colak
authors.initials: NC
authors.lastname: Bozkurt
authors.affiliation: GENAR Institute for Public Health & Genomics Research, Ankara, Turkey.|Department of Social Medicine, Maastricht University, Maastricht, The Netherlands.
authors.forename: Tomris
authors.initials: T
authors.lastname: Cesuroglu
authors.affiliation: Department of Biology, Faculty of Science & Arts, Aksaray University, Aksaray, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karaca
authors.affiliation: Department of Cardiology, Ataturk Training & Research Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bozkurt
authors.affiliation: Metabolism Unit, Numune Training & Research Hospital, Ankara, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Eskioglu
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.
authors.forename: Renato
authors.initials: R
authors.lastname: Polimanti
mesh_terms: D000368:Aged; D000465:Algorithms; D000925:Anticoagulants / Q000008:administration & dosage*; D054796:Drug Dosage Calculations; D005260:Female; D005838:Genotype; D006474:Hemorrhagic Disorders / Q000235:genetics* / Q000517:prevention & control*; D006801:Humans; D019934:International Normalized Ratio / Q000379:methods; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics / Q000379:methods; D013923:Thromboembolism / Q000188:drug therapy / Q000235:genetics; D014421:Turkey; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D014859:Warfarin
keywords: Turkey; drug response; ethnicity; pharmacogenetic algorithms; validation study