title: Ratcheting of RNA polymerase toward structural principles of RNA polymerase operations.
abstract: RNA polymerase (RNAP) performs various tasks during transcription by changing its conformational states, which are gradually becoming clarified. A recent study focusing on the conformational transition of RNAP between the ratcheted and tight forms illuminated the structural principles underlying its functional operations.
authors.affiliation: a Division of Structural and Synthetic Biology ; RIKEN Center for Life Science Technologies ; Suehiro-cho, Tsurumi-ku , Yokohama , Japan.
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Sekine
authors.forename: Yuko
authors.initials: Y
authors.lastname: Murayama
authors.forename: Vladimir
authors.initials: V
authors.lastname: Svetlov
authors.forename: Evgeny
authors.initials: E
authors.lastname: Nudler
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yokoyama
mesh_terms: D001419:Bacteria / Q000145:classification / Q000201:enzymology / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000378:metabolism*; D005786:Gene Expression Regulation; D008958:Models, Molecular; D011487:Protein Conformation; D014158:Transcription, Genetic
chemical_list: D012321:DNA-Directed RNA Polymerases
keywords: RNA polymerase; structure-function relationship; transcription; transcription factor; transcription regulation