title: Comparison of first pass bolus AIFs extracted from sequential18F-FDG PET and DSC-MRI of mice.
abstract: Accurate kinetic modelling of in vivo physiological function using positron emission tomography (PET) requires determination of the tracer time-activity curve in plasma, known as the arterial input function (AIF). The AIF is usually determined by invasive blood sampling methods, which are prohibitive in murine studies due to low total blood volumes. Extracting AIFs from PET images is also challenging due to large partial volume effects (PVE). We hypothesise that in combined PET with magnetic resonance imaging (PET/MR), a co-injected bolus of MR contrast agent and PET ligand can be tracked using fast MR acquisitions. This protocol would allow extraction of a MR AIF from MR contrast agent concentration-time curves, at higher spatial and temporal resolution than an image-derived PET AIF. A conversion factor could then be applied to the MR AIF for use in PET kinetic analysis. This work has compared AIFs obtained from sequential DSC-MRI and PET with separate injections of gadolinium contrast agent and18F-FDG respectively to ascertain the technique's validity. An automated voxel selection algorithm was employed to improve MR AIF reproducibility. We found that MR and PET AIFs displayed similar character in the first pass, confirmed by gamma variate fits (p<0.02). MR AIFs displayed reduced PVE compared to PET AIFs, indicating their potential use in PET/MR studies.
authors.affiliation: Wolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
authors.forename: Eleanor
authors.initials: E
authors.lastname: Evans
authors.affiliation: Wolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK ; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Sawiak
authors.affiliation: Wolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Ward
authors.affiliation: Wolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
authors.forename: Guido
authors.initials: G
authors.lastname: Buonincontri
authors.affiliation: Wolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hawkes
authors.affiliation: Wolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
authors.forename: T Adrian
authors.initials: TA
authors.lastname: Carpenter