title: Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents.
abstract: A synergistic impact of research in the fields of post-angioplasty restenosis, drug-eluting stents and vascular gene therapy over the past 15 years has shaped the concept of gene-eluting stents. Gene-eluting stents hold promise of overcoming some biological and technical problems inherent to drug-eluting stent technology. As the field of gene-eluting stents matures it becomes evident that all three main design modules of a gene-eluting stent: a therapeutic transgene, a vector and a delivery system are equally important for accomplishing sustained inhibition of neointimal formation in arteries treated with gene delivery stents. This review summarizes prior work on stent-based gene delivery and discusses the main optimization strategies required to move the field of gene-eluting stents to clinical translation.
authors.affiliation: Dept of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, USA ; The University of Pennsylvania, USA.
authors.forename: Ilia
authors.initials: I
authors.lastname: Fishbein
authors.affiliation: Dept of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, USA ; The University of Pennsylvania, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Chorny
authors.affiliation: Dept of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, USA.
authors.forename: Richard F
authors.initials: RF
authors.lastname: Adamo
authors.affiliation: Dept of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, USA.
authors.forename: Scott P
authors.initials: SP
authors.lastname: Forbes
authors.affiliation: Dept of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, USA.
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Corrales
authors.affiliation: Dept of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, USA ; The University of Pennsylvania, USA.
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Alferiev
authors.affiliation: Dept of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, USA ; The University of Pennsylvania, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Levy
keywords: Endovascular stents; Restenosis; Vascular gene delivery