title: Real-life practice of antiviral therapy and disease patterns of patients with chronic hepatitis B: a single-center retrospective observation study.
abstract: OBJECTIVE
  To analyze the spectrum of diseases in patients with chronic hepatitis B virus (HBV) infection and their association with patient clinicopathologic characteristics and the effect of antiviral therapy on the spectrum of diseases in the study cohort.
  
  
  METHODS
  We retrospectively reviewed the clinicopathologic and virologic records of patients with chronic HBV infection hospitalized at our institution during 2011. Demographic data, hepatitis B e antigen (HBeAg) status and HBV DNA (log10 IU/ml) were obtained.
  
  
  RESULTS
  A total of 1,619 patients were included; 272 (17.2 %) patients received antiviral therapy for a mean duration of 24.5 ± 18.3 months, and 71.0 % (198/279) patients were compliant with their antiviral therapy. HBeAg-positive patients had a markedly higher rate of moderate and severe CHB than HBeAg-negative patients (p < 0.001) but a significantly lower rate of liver cirrhosis (p < 0.001). The rate of severe and fulminant CHB was significantly lower in patients receiving antiviral therapy than in those not receiving antiviral therapy.
  
  
  CONCLUSIONS
  Patients receiving antiviral therapy exhibit a different spectrum of diseases from patients not receiving such therapy.
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road No. 600, Guangzhou, 510630, China.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Jie
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road No. 600, Guangzhou, 510630, China.
authors.forename: Xiangyong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road No. 600, Guangzhou, 510630, China.
authors.forename: Guoli
authors.initials: G
authors.lastname: Lin
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road No. 600, Guangzhou, 510630, China.
authors.forename: Yuankai
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road No. 600, Guangzhou, 510630, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road No. 600, Guangzhou, 510630, China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road No. 600, Guangzhou, 510630, China. chongyutian_1980@163.com.
authors.forename: Yutian
authors.initials: Y
authors.lastname: Chong
keywords: Antiviral therapy; Disease spectrum; Hepatitis B virus; Interferon; Nucleotide analogs