title: What Will It Take to Cure HIV?
abstract: Investigational strategies to attempt HIV cure or remission include very early initiation of antiretroviral therapy to limit the latent HIV reservoir and preinfection vaccination. In the setting of viral suppression, strategies include reactivation of latently infected cells (eg, through "shock" therapy with histone deacetylase inhibitors or other agents); use of broadly neutralizing antibodies, therapeutic vaccines, immunotoxins, or other immune-based therapies to kill latently infected cells; and gene editing to induce target cell resistance (eg, by eliminating the CC chemokine receptor 5 [CCR5] coreceptor). Improved ability to detect and quantify very low levels of virus is needed. This article summarizes a presentation by Jintanat Ananworanich, MD, PhD, at the IAS-USA continuing education program held in New York, New York, in October 2014.
authors.affiliation: US Military HIV Research Program and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D057134:Antibodies, Neutralizing / Q000627:therapeutic use; D035843:Biomedical Research / Q000639:trends; D055808:Drug Discovery / Q000639:trends; D006678:HIV / Q000187:drug effects / Q000502:physiology; D015483:HIV Antibodies / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control*; D006801:Humans; D055502:Secondary Prevention; D014611:Vaccination / Q000379:methods; D014775:Virus Activation / Q000187:drug effects; D017735:Virus Latency / Q000187:drug effects
chemical_list: D016915:AIDS Vaccines; D044966:Anti-Retroviral Agents; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies