title: Topical Oxygen for Chronic Wounds: A PRO/CON Debate.
abstract: The role of oxygen in wound healing is universally accepted and does not require any further evidence; however the controversy as to whether oxygen delivery systems have the potential to improve wound healing remains to be concluded. Topical oxygen treatment (TOT) involves the delivery of 100% oxygen for a mean of 90 min, once a day at an atmospheric pressure slightly above 1 atm abs. The use of TOT gained increasing interest recently. The current manuscript will summarize the pros and cons of TOT in the view of the available literature.
authors.affiliation: Department of Underwater and Hyperbaric Medicine, GATA Haydarpasa Teaching Hospital, 34668 Uskudar, Istanbul, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Mutluoglu
authors.affiliation: Department of Underwater and Hyperbaric Medicine, Ankara Numune Teaching and Research Hospital, Ankara, Turkey.
authors.forename: Aslican
authors.initials: A
authors.lastname: Cakkalkurt
authors.affiliation: Department of Underwater and Hyperbaric Medicine, GATA Faculty of Medicine, Etlik, Ankara, Turkey.
authors.forename: Gunalp
authors.initials: G
authors.lastname: Uzun
authors.affiliation: Department of Underwater and Hyperbaric Medicine, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Samil
authors.initials: S
authors.lastname: Aktas
keywords: Hyperbaric oxygen; Oxidative stress; Reactive oxygen species; Topical oxygen; Wound healing