title: Salt-water imbalance and fluid overload in hemodialysis patients: a pivotal role of corin.
abstract: Natriuretic peptides (NP) play a key role in regulation of salt and water balance. Corin, a serine protease which activates NP, plays a key role in regulation of blood pressure and cardiac function. The aim of the study was to evaluate the involvement of corin in renal physiopathology, analyze its levels in dialyzed patients and evaluate its relation with fluid overload and comorbidities such as heart failure and blood hypertension. We studied serum corin in uremic patients (n = 20) undergoing hemodialysis therapy (HD) and in healthy subjects (HS). Corin levels in uremic patients were higher than in HS (p < 0.0001). Moreover, its concentration did not change after a single HD session. Hypertensive patients and subject suffering from heart failure were characterized by high values of corin. After multivariate analysis, direct correlations were maintained between corin and dialysis vintage (β = 0.83; p = 0.0002), heart failure (β = 0.42; p < 0.0001), systolic blood pressure (β = -0.70; p = 0.0002) and body weight (β = -0.39; p < 0.0001). Corin might be implicated in the regulation of salt and water balance and the disturbances of volume homeostasis of HD patients. However, further studies are warranted to understand the role of corin in kidney diseases and to define its diagnostic and prognostic role.
authors.affiliation: Department of Clinical and Experimental Medicine, University Hospital of Messina, 98100, Messina, Italy. carloalbertoricciardi@gmail.com.
authors.forename: Carlo Alberto
authors.identifier: http://orcid.org/0000-0001-7383-6376
authors.initials: CA
authors.lastname: Ricciardi
authors.affiliation: Department of Clinical and Experimental Medicine, University Hospital of Messina, 98100, Messina, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lacquaniti
authors.affiliation: Department of Clinical and Experimental Medicine, University Hospital of Messina, 98100, Messina, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Cernaro
authors.affiliation: Department of Clinical and Experimental Medicine, University Hospital of Messina, 98100, Messina, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Bruzzese
authors.affiliation: Department of Clinical and Experimental Medicine, University Hospital of Messina, 98100, Messina, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Visconti
authors.affiliation: Department of Pathology, University of Messina, Messina, Italy.
authors.forename: Saverio
authors.initials: S
authors.lastname: Loddo
authors.affiliation: Department of Clinical and Experimental Medicine, University Hospital of Messina, 98100, Messina, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Santoro
authors.affiliation: Department of Clinical and Experimental Medicine, University Hospital of Messina, 98100, Messina, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume; D003956:Dialysis; D005260:Female; D064368:Healthy Volunteers; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012492:Salts / Q000097:blood*; D012697:Serine Endopeptidases / Q000097:blood*; D014511:Uremia / Q000628:therapy; D014867:Water
chemical_list: D012492:Salts; D014867:Water; C119812:CORIN protein, human; D012697:Serine Endopeptidases
keywords: Atrial natriuretic peptide (ANP); Biomarker; Brain natriuretic peptide (BNP); Corin; Heart failure; Natriuretic peptides; Salt and water balance