title: A new approach towards the synthesis of drospirenone and steroidal spirolactones.
abstract: A general methodology for the synthesis of different steroidal 17-spirolactones is described. This method uses lithium acetylide of ethyl propiolate as the three carbon synthon and the method was successfully applied for the process development of drospirenone.
authors.affiliation: Evestra, Inc., San Antonio, TX, USA. Electronic address: bsanthamma@evestra.com.
authors.forename: Bindu
authors.initials: B
authors.lastname: Santhamma
authors.affiliation: Evestra, Inc., San Antonio, TX, USA.
authors.forename: Kirk
authors.initials: K
authors.lastname: Acosta
authors.affiliation: Evestra, Inc., San Antonio, TX, USA.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Chavez-Riveros
authors.affiliation: Evestra, Inc., San Antonio, TX, USA.
authors.forename: Klaus
authors.initials: K
authors.lastname: Nickisch
mesh_terms: D000736:Androstenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013148:Spironolactone / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000736:Androstenes; D013148:Spironolactone; C035144:drospirenone
keywords: Drospirenone; Ethyl propiolate; Spirolactone