title: Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation.
abstract: Careful design of nanoparticles plays a crucial role in their biomedical applications. It not only defines the stability of nanoparticles in a biological medium but also programs their biological functionality and specific interactions with cells. Here, an inorganic nanoparticulate system engineered to have a dual role as anti-angiogenic and hyperthermic agent is presented. The inorganic rod-shaped core is designed to strongly absorb near-infrared laser irradiation through the surface plasmon resonance and convert it into localized heat, while a peptide coating acts as an anti-angiogenic drug, altogether inhibiting vascular growth. The synergistic dual action provides an improved inhibition of the in vitro tumour angiogenesis, offering new possibilities for the development of nano-engineered anti-angiogenic drugs for therapies.
authors.affiliation: Physics and Astronomy, Faculty of Applied and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, UK. a.kanaras@soton.ac.uk.
authors.forename: Dorota
authors.initials: D
authors.lastname: Bartczak
authors.forename: Otto L
authors.initials: OL
authors.lastname: Muskens
authors.forename: Simone
authors.initials: S
authors.lastname: Nitti
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Millar
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Kanaras
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D001686:Biological Phenomena; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006979:Hyperthermia, Induced; D008024:Ligands; D028022:Low-Level Light Therapy / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D020349:Surface Plasmon Resonance
chemical_list: D020533:Angiogenesis Inhibitors; D008024:Ligands