title: Treatment of MDR-Gram negative infections in the 21st century: a never ending threat for clinicians.
abstract: The spread of antimicrobial resistance among Gram negative bacteria has dramatically reduced the current therapeutic opportunities and hampered the perspectives of drug discovery pipeline. Several unmet needs concerning the optimal therapeutic approaches to severe infections caused by the leading multi-drug-resistant GNB are still unresolved, mainly in relationship with the difficulty in the design of prospective comparative studies. Therefore a perspective of how the main resistance patterns and the related infections can be managed in the absence of more definitive data is mandatory.
authors.affiliation: Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. Electronic address: pierluigi.viale@unibo.it.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Viale
authors.affiliation: Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Giannella
authors.affiliation: Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Tedeschi
authors.affiliation: Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: Russell
authors.initials: R
authors.lastname: Lewis
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D065093:beta-Lactamase Inhibitors / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D065093:beta-Lactamase Inhibitors