title: Serine-arginine protein kinase 1 is associated with hepatocellular carcinoma progression and poor patient survival.
abstract: The pre-mRNA splicing regulator serine-arginine protein kinase 1 (SRPK1) promotes cancer development and various pathophysiological processes. However, the clinical relevance of SRPK1 in hepatocellular carcinoma (HCC) is not clear. This study investigates the expression and prognostic value of SRPK1 in HCC. We found that SRPK1 expression was significantly upregulated at the mRNA and protein level in all HCC cell lines or HCC tissue samples compared with the hepatic cell line or matched noncancerous tissue samples, respectively. Higher SRPK1 expression significantly correlated with clinical staging (p = 0.031), survival time (p = 0.004), and gender (p = 0.011) of HCC patients. Together, our study showed that SRPK1 is overexpressed in HCC and may be a promising indicator of prognosis for HCC patients.
authors.affiliation: Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9th Jinsui Road, Postal Code 510000, Guangzhou, Guangdong, 510623, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9th Jinsui Road, Postal Code 510000, Guangzhou, Guangdong, 510623, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Wenfei
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9th Jinsui Road, Postal Code 510000, Guangzhou, Guangdong, 510623, People's Republic of China.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9th Jinsui Road, Postal Code 510000, Guangzhou, Guangdong, 510623, People's Republic of China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Tan
authors.affiliation: Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9th Jinsui Road, Postal Code 510000, Guangzhou, Guangdong, 510623, People's Republic of China.
authors.forename: Peiying
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Clinical Examination, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510260, People's Republic of China.
authors.forename: Hongyun
authors.initials: H
authors.lastname: Jia
authors.affiliation: Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510260, People's Republic of China.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9th Jinsui Road, Postal Code 510000, Guangzhou, Guangdong, 510623, People's Republic of China. gs1975@163.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Shen
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D045744:Cell Line, Tumor; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012737:Sex Factors; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D012333:RNA, Messenger; C087728:SRPK1 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: Hepatocellular carcinoma; Prognosis; SRPK1