title: β-Catenin Alterations in Squamous Cell Carcinoma of the Lip.
abstract: This study aimed to investigate the correlation between β-catenin immunoexpression and histopathological grades of lower lip squamous cell carcinoma (LSCC). β-Catenin abnormal expression was found in 29% of the squamous cells of well differentiated LSCC, 63% of moderately differentiated and 86% of poorly differentiated, and therefor was significantly associated with histological grade (p=0.000). Nuclear β-catenin expression appeared in 5% of the cells and was also correlated with the histological grades (p=0.000). In 14.7% of the cells it was localized in the cytoplasm, again correlating with histology (p=0.002). According to this study the expression of β-catenin is an independent prognostic factor for histological grade and to the tumor differentiation. This appears to reflect a structural association and the role of β-catenin in tumor progression.
authors.affiliation: Department of Oral Histology and Pathology , Faculty of Dentistry, University of Damascus, Damascus, Syria E-mail : dr.barakat.sh@gmail.com.
authors.forename: Charif
authors.initials: C
authors.lastname: Barakat
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008048:Lip Neoplasms / Q000378:metabolism* / Q000473:pathology; D009055:Mouth / Q000378:metabolism* / Q000473:pathology; D060787:Neoplasm Grading; D011379:Prognosis; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D051176:beta Catenin