title: Effects of Melatonin on Stress-Induced Changes in the Liver of Rats with Different Resistance to Stress.
abstract: Effects of melatonin on changes in the liver structures were studied in stress-resistant and stress-sensitive rats exposed to chronic stress. It was found that the number of degenerative cells increased and intralobular sinusoidal capillary enlarged in the liver of animals of both groups. These parameters were significantly higher in stress-sensitive rats. Melatonin (1 mg/kg) reduced the severity of degenerative changes and stimulated the development of reparative processes in the liver tissue. The effects of the hormone was more pronounced in rats sensitive to stress and was noted after melatonin administration in a dose of 0.2 mg/kg.
authors.affiliation: Department of Pathophysiology, Kursk State Medical University, Kursk, Russia, medps@yandex.ru.
authors.forename: V S
authors.initials: VS
authors.lastname: Serikov
authors.forename: Yu D
authors.initials: YD
authors.lastname: Lyashev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000187:drug effects / Q000502:physiology*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D008550:Melatonin