title: Pediatric cancer genomics, a play rather than a portrait.
abstract: Relapsed neuroblastoma is common, frequently lethal and poorly studied and poses a major treatment challenge. Two new studies shed light on the genomic landscape of recurrent neuroblastoma and demonstrate profound differences between the disease at diagnosis and relapse.
authors.affiliation: Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Vijay
authors.identifier: 000000026557895X
authors.initials: V
authors.lastname: Ramaswamy
authors.affiliation: Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D023281:Genomics; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D009447:Neuroblastoma / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D018631:ras Proteins / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D020928:Mitogen-Activated Protein Kinases; D018631:ras Proteins