title: Determination of muscle mitochondrial respiratory capacity in Standardbred racehorses as an aid to predicting exertional rhabdomyolysis.
abstract: This prospective cohort study evaluated the potential of high-resolution respirometry applied to permeabilized muscle fibers for fitness evaluation in French Standardbred racehorses. Fitness evaluation by means of respirometric parameters did not correlate with racing performance registered over the following racing season. However, altered mitochondrial energy metabolism was associated with higher risk of developing exertional rhabdomyolysis, a common cause of exercise intolerance in racehorses. These data represent a first step towards establishing reference values for muscle OXPHOS capacity in this breed.
authors.affiliation: Equine Department, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, Bat B41 & B42, University of Liege, Sart Tilman, 4000 Liège, Belgium.
authors.forename: Rosa
authors.initials: R
authors.lastname: Houben
authors.affiliation: EQUI-TEST, Grez-en-Bouère, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Leleu
authors.affiliation: Equine Department, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, Bat B41 & B42, University of Liege, Sart Tilman, 4000 Liège, Belgium.
authors.forename: Audrey
authors.initials: A
authors.lastname: Fraipont
authors.affiliation: Equine Department, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, Bat B41 & B42, University of Liege, Sart Tilman, 4000 Liège, Belgium; Center for Oxygen Research and Development (CORD) Institute of Chemistry Bat B6a, Liège University, Sart Tilman, 4000 Liège, Belgium.
authors.forename: Didier
authors.initials: D
authors.lastname: Serteyn
authors.affiliation: Equine Department, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, Bat B41 & B42, University of Liege, Sart Tilman, 4000 Liège, Belgium. Electronic address: dominique.votion@ulg.ac.be.
authors.forename: Dominique-M
authors.initials: DM
authors.lastname: Votion
mesh_terms: D000818:Animals; D019069:Cell Respiration; D005260:Female; D005602:France; D006734:Horse Diseases / Q000473:pathology* / Q000503:physiopathology*; D006736:Horses; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009132:Muscles / Q000502:physiology*; D005082:Physical Exertion; D011446:Prospective Studies; D012206:Rhabdomyolysis / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*
keywords: Exertional rhabdomyolysis; High-resolution respirometry; Horse; Mitochondria; Muscle; OXPHOS