title: The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study.
abstract: OBJECTIVE
  The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.
  
  
  METHODS
  Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.
  
  
  RESULTS
  CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.
  
  
  CONCLUSIONS
  In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.
authors.affiliation: Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: khoa89dinh@gmail.com.
authors.forename: Khoa M
authors.initials: KM
authors.lastname: Dinh
authors.affiliation: Dept. of Clinical Immunology, Naestved Hospital, Naestved, Ringstedgade 61, DK-4700 Naestved, Denmark. Electronic address: olbp@regionsjaelland.dk.
authors.forename: Ole B
authors.initials: OB
authors.lastname: Pedersen
authors.affiliation: Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: mikkel.petersen@skejby.rm.dk.
authors.forename: Mikkel S
authors.initials: MS
authors.lastname: Petersen
authors.affiliation: Dept. of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: erik.soerensen@regionh.dk.
authors.forename: Erik
authors.initials: E
authors.lastname: Sørensen
authors.affiliation: Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: ceciliejuulsorensen@gmail.com.
authors.forename: Cecilie J
authors.initials: CJ
authors.lastname: Sørensen
authors.affiliation: Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: kathrinekaspersen@gmail.com.
authors.forename: Kathrine A
authors.initials: KA
authors.lastname: Kaspersen
authors.affiliation: Dept. of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: Margit.Anita.Hoerup.Larsen@regionh.dk.
authors.forename: Margit H
authors.initials: MH
authors.lastname: Larsen
authors.affiliation: Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: bjamoell@rm.dk.
authors.forename: Bjarne
authors.initials: B
authors.lastname: Møller
authors.affiliation: Dept. of Epidemiology Research, Statens Serums Institut, Copenhagen S, Artillerivej 5, DK-2300 Copenhagen S, Denmark. Electronic address: HHJ@ssi.dk.
authors.forename: Henrik
authors.initials: H
authors.lastname: Hjalgrim
authors.affiliation: Dept. of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: Henrik.Ullum@regionh.dk.
authors.forename: Henrik
authors.initials: H
authors.lastname: Ullum
authors.affiliation: Dept. of Clinical Immunology, Aarhus University Hospital, Aarhus N, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: christian.erikstrup@skejby.rm.dk.
authors.forename: Christian
authors.initials: C
authors.lastname: Erikstrup
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D017353:Gene Deletion; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006760:Hospitalization; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D019713:Receptors, CCR5 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C584933:CCR5 protein, human; D005819:Genetic Markers; D019713:Receptors, CCR5; D002097:C-Reactive Protein
keywords: Atherosclerosis; CCR5 receptor; Cardiovascular diseases; Epidemiology; Genetics; Inflammation