title: New furoquinoline alkaloid and flavanone glycoside derivatives from the leaves of Oricia suaveolens and Oricia renieri (Rutaceae).
abstract: Fractionation of the methanol extract of the leaves of Oricia renieri and Oricia suaveolens (Rutaceae) led to the isolation of 13 compounds including the hitherto unknown furoquinoline alkaloid named 6,7-methylenedioxy-5-hydroxy-8-methoxy-dictamnine (1) and a flavanone glycoside named 5-hydroxy-4'-methoxy-7-O-[α-L-rhamnopyranosyl(1‴→5″)-β-D-apiofuranosyl]-flavanoside (2), together with 11 known compounds (3-13). The structures of the compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data and comparison. All compounds isolated were examined for their activity against human carcinoma cell lines. The alkaloids 1, 5, 12, 13 and the phenolic 2, 8, 11 tested compounds exhibited non-selective moderate cytotoxic activity with IC50 8.7-15.9 μM whereas compounds 3, 4, 6, 7, 9 and 10 showed low activity.
authors.affiliation: a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon.
authors.forename: Achille B
authors.initials: AB
authors.lastname: Nouga
authors.affiliation: a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Ndom
authors.affiliation: b Department of Pharmacy , University of Douala , Douala P.O. Box 2701 , Cameroon.
authors.forename: Emmanuel M
authors.initials: EM
authors.lastname: Mpondo
authors.affiliation: b Department of Pharmacy , University of Douala , Douala P.O. Box 2701 , Cameroon.
authors.forename: Judith Caroline Ngo
authors.initials: JC
authors.lastname: Nyobe
authors.affiliation: a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon.
authors.forename: Alain
authors.initials: A
authors.lastname: Njoya
authors.affiliation: a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon.
authors.forename: Luc M
authors.initials: LM
authors.lastname: Meva'a
authors.affiliation: c Department of Chemistry , University of Reading , Whitenights, Reading RG6 6AD , UK.
authors.forename: Phillipa B
authors.initials: PB
authors.lastname: Cranwell
authors.affiliation: d Lennard Jones Laboratory, Department of Chemistry, School of Physical and Geographical Sciences , University of Keele , Staffordshire ST5 5BG , UK.
authors.forename: James A S
authors.initials: JA
authors.lastname: Howell
authors.affiliation: c Department of Chemistry , University of Reading , Whitenights, Reading RG6 6AD , UK.
authors.forename: Laurence M
authors.initials: LM
authors.lastname: Harwood
authors.affiliation: a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon.
authors.forename: Jean Duplex
authors.initials: JD
authors.lastname: Wansi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D047309:Flavones / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011804:Quinolines / Q000302:isolation & purification* / Q000494:pharmacology*; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D010936:Plant Extracts; D011804:Quinolines
keywords: Oricia; cytotoxicity; flavanone glycoside; furoquinoline; renieri; suaveolens