title: Squalenoylation of Chitosan: A Platform for Drug Delivery?
abstract: The present study describes the synthesis of chitosan-squalene (chitosan-SQ), a unique amphiphilic chitosan derivative, which enables the efficient formation of nanoparticles in acetate buffer by self-assembly. The influence of different parameters on the nanoparticle size such as percentage of substitution, pH of the acetate buffer, concentration in chitosan-SQ, and time of stirring was studied. It could be demonstrated that this new polymer was nontoxic to cells, biodegradable, and preserved the anti-infective properties of the initial chitosan.1 Moreover, chitosan-SQ showed good carrier properties by allowing the encapsulation of both hydrophilic and hydrophobic model drug compounds.
authors.affiliation: Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University , Saarbrücken 66123, Germany.
authors.forename: Elise
authors.initials: E
authors.lastname: Lepeltier
authors.affiliation: Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University , Saarbrücken 66123, Germany.
authors.forename: Brigitta
authors.initials: B
authors.lastname: Loretz
authors.affiliation: Faculté de Pharmacie, Institut Galien Paris Sud, Université Paris Sud, UMR CNRS 8612 , Paris 92296, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Desmaële
authors.affiliation: Institut für Pharmazeutische Biologie, Saarland University , Saarbrücken 66123, Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Zapp
authors.affiliation: Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University , Saarbrücken 66123, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Herrmann
authors.affiliation: Faculté de Pharmacie, Institut Galien Paris Sud, Université Paris Sud, UMR CNRS 8612 , Paris 92296, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
authors.affiliation: Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University , Saarbrücken 66123, Germany.|Department of Pharmacy, Saarland University , Saarbrücken 66123, Germany.
authors.forename: Claus-Michael
authors.initials: CM
authors.lastname: Lehr
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D013185:Squalene / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D004337:Drug Carriers; D013185:Squalene; D048271:Chitosan