title: [Study of effective components and molecular mechanism for Guizhi Fuling formula treatment of dysmenorrhea, pelvic inflammatory disease and uterine fibroids].
abstract: In this study, the active components and potential molecular .mechanism of Guizhi Fuling formula in treatment on dysmenorrhea, pelvic inflammation, and hysteromyoma were investigated using network pharmacological methods. Sterols and pentacyclic triterpenes, with high moleculal network degree, revealed promising effects on anti-inflammatory, analgesic, anti-tumor, and immune-regulation, according to D-T network analysis. On the other hand, the targets with high degree were involved in inflammatory, coagulation, angiopoiesis, smooth muscle contraction, and cell reproduction, which showed the novel function in anti-dysmenorrhea, pelvic inflammation, and hysteromyoma. Furthermore, the formula was indicated to play a key role in smooth muscle proliferation, inhibition of new vessels, circulation improvement, reduction of hormone secretion, alleviation of smooth muscle, block of arachidonic acid metabolism, and inflammation in uterus. Thus, the main mechanism of Guizhi Fuling formula was summarized. In conclusion, Guizhi Fuling formula was proven to alleviated dysmenorrhea, pelvic inflammation, and hysteromyoma by acting on multiple targets through several bioactive compounds, regulating 21 biological pathways.
authors.forename: Zhi-peng
authors.initials: ZP
authors.lastname: Ke
authors.forename: Xin-zhuang
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Ding
authors.forename: Ze-yu
authors.initials: ZY
authors.lastname: Cao
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Cao
authors.forename: Tuan-jie
authors.initials: TJ
authors.lastname: Wang
authors.forename: Chen-feng
authors.initials: CF
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
authors.forename: Zhen-zhong
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Xu
mesh_terms: D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004412:Dysmenorrhea / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D005260:Female; D053263:Gene Regulatory Networks / Q000187:drug effects*; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; C525079:guizhi-fuling