title: The Impact of Thyroid Autoimmunity on the Clinical and Diabetes Parameters of Patients with Latent Autoimmune Diabetes in Adults.
abstract: OBJECTIVE
  We evaluated the clinical and diabetes parameters of latent autoimmune diabetes in adults (LADA) patients according to the presence of thyroid autoimmunity (TA).
  
  
  METHODS
  Patients with LADA (diabetes onset after 30 years of age, no need for insulin treatment for at least 6 months after diabetes onset, positive for glutamic acid decarboxylase antibodies (GADA)) were evaluated for the presence of thyroid peroxidase antibodies (TPOAb) and were subjected to clinical and laboratory evaluations of the glycated hemoglobin and basal C peptide levels. The patients were stratified into either group A (with TA) or group B (without TA).
  
  
  RESULTS
  We evaluated 104 (57 female and 47 male) patients with LADA. The mean age at diabetes onset was 44±10 years. The prevalence of TA among the LADA patients was 28.8% (30 patients; 23 female and 7 male). In groups A and B, the mean age at diabetes onset was 41.47±10.15 and 45.07±10 years (p=0.03), the basal C peptide level was 0.69±0.16 and 1.9±1.3 ng/ml (p<0.0001), the glycated hemoglobin level was 9.8±2.2 and 9.1±2.2 (p=0.04), and the time to insulin treatment was 3.2±2.1 years and 4.98±2.2 years (p=0.038), respectively. The use of a basal bolus insulin regimen was more frequent in group A than in group B (56.7% and 35.1%, respectively; p=0.03).
  
  
  CONCLUSIONS
  TA identifies a particular phenotype of LADA displaying a higher GADA titer, lower basal C peptide levels and poorer glycemic control.
authors.affiliation: Endocrinology and Diabetes Department, Elias University Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
authors.forename: A D
authors.initials: AD
authors.lastname: Reghina
authors.affiliation: Endocrinology and Diabetes Department, Elias University Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
authors.forename: S
authors.initials: S
authors.lastname: Florea
authors.affiliation: Endocrinology and Diabetes Department, Elias University Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Constantin
authors.affiliation: Endocrinology and Diabetes Department, Elias University Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
authors.forename: S
authors.initials: S
authors.lastname: Fica
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013967:Thyroiditis, Autoimmune / Q000097:blood* / Q000209:etiology
chemical_list: D001323:Autoantibodies