title: Association between serum interleukin-35 levels and severity of acute pancreatitis.
abstract: Inflammatory cytokines have been reported to be associated with pathogenesis of acute pancreatitis. The aim of this study was to measure the serum IL-35 levels in patients with acute pancreatitis and analyze the relationship between IL-35 levels and the disease severity. Thirty-two patients with acute pancreatitis and 32 healthy control subjects were included into the study. The serum levels of IL-35 were measured by enzyme-linked immunosorbent assay upon admission and the following seven days. The relationships with severity and etiology during the clinical course were analyzed. Serum IL-35 levels in patients with acute pancreatitis at the time of admission (5.25±0.37 ng/mL) were significantly higher than those in healthy controls (1.93±0.16 ng/mL, P<0.001). Moreover, serum IL-35 levels in patients with severe attacks (7.15±0.48 ng/mL) were significantly higher than those with moderately severe attacks (5.14±0.49 ng/mL, P=0.01) and mild attacks (3.69±0.53 ng/mL, P<0.001). However, there was no significant difference of serum IL-35 levels among patients with acute pancreatitis due of alcohol, gallstone and idiopathy. In addition, the peak serum concentrations of IL-35 were on day 1 after admission. Our results demonstrate that increased serum IL-35 levels may be related to the inflammatory response in patients with acute pancreatitis, suggesting that IL-35 may be used for a potential biomarker of acute pancreatitis.
authors.affiliation: Intensive Care Unit, Jinhua Municipal Central Hospital Jinhua 321000, Zhejiang, China.
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Jinhua Municipal Central Hospital Jinhua 321000, Zhejiang, China.
authors.forename: Xiu-Yun
authors.initials: XY
authors.lastname: Zhou
authors.affiliation: Department of Internal Medicine, The Second Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
authors.forename: Xian-Yang
authors.initials: XY
authors.lastname: Guo
authors.affiliation: Department of Respiration, Jinhua Municipal Central Hospital Jinhua 321000, Zhejiang, China.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Tu
keywords: Acute pancreatitis; biomarker; serum interleukin-35