title: [AA-type amyloidosis secondary to multidrug resistant pulmonary tuberculosis: implications for therapy].
abstract: Multidrug resistant pulmonary tuberculosis was diagnosed to a 32-year-old man. An AA-amyloidosis was subsequently diagnosed on the renal biopsy performed for nephrotic syndrome and macroscopic hematuria. A 6-drug antibiotic treatment was delivered quickly after first results of genotypic antibiogram given the renal failure, and was secondarily adapted to the phenotypic antibiogram. Multidrug therapy was fairly well tolerated. Clinical and biological improving were slow. Although tuberculosis is a classic cause of amyloidosis, this is the first case reporting an association between a multidrug resistant case and an amyloidosis in adults. This case also raises the question of MDR probabilistic treatments in situations whether a vital organ prognosis is engaged.
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address: elisabeth.baux@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Baux
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: S
authors.initials: S
authors.lastname: Henard
authors.affiliation: Laboratoire de bactériologie, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Alauzet
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: F
authors.initials: F
authors.lastname: Goehringer
authors.affiliation: Laboratoire de bactériologie, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Laurain
authors.affiliation: Laboratoire d'anatomie et cytologie pathologiques, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: J
authors.initials: J
authors.lastname: Champigneulle
authors.affiliation: Service de pneumologie, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: P
authors.initials: P
authors.lastname: Vaillant
authors.affiliation: Département de soins polyvalents - Sanatorium, centre médical de Bligny, 91640 Bris-sous-Forges, France.
authors.forename: A
authors.initials: A
authors.lastname: Hardy
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Rabaud
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Nancy-Brabois, 9, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: T
authors.initials: T
authors.lastname: May
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000209:etiology*; D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications* / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents
keywords: Amyloidosis; Amylose; Multi-résistance; Multidrug resistant; Tuberculose; Tuberculosis