title: Treatment of neonatal fungal infective endocarditis with recombinant tissue plasminogen: activator in a low birth weight infant case report and review of the literature.
abstract: With advances in medical sciences, an increase in survival rates of low birth weight; increased incidence in use of catheter and antibiotics, and total parenteral nutrition are reported, therefore, the rate of fungal infections in late and very late onset neonatal sepsis have increased. Although fungal endocarditis rarely occur in newborns, it has a high morbidity and mortality. Antifungal therapy is often insufficient in cases who develop fungal endocarditis and surgical treatment is not preferred due to its difficulty and high mortality. Herein, fungal endocarditis in a preterm newborn treated with single-dose recombinant tissue plasminogen activator in addition to antifungal therapy is presented and relevant literature has been reviewed. The vegetation completely disappeared following treatment and no complication was observed.
authors.affiliation: Department of Neonatology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
authors.forename: Aslan
authors.initials: A
authors.lastname: Babayigit
authors.affiliation: Department of Neonatology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Cebeci
authors.affiliation: Department of Neonatology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Buyukkale
authors.affiliation: Department of Neonatology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
authors.forename: Seda Yılmaz
authors.initials: SY
authors.lastname: Semerci
authors.affiliation: Department of Cardiology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
authors.forename: Helen
authors.initials: H
authors.lastname: Bornaun
authors.affiliation: Department of Cardiology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
authors.forename: Kazim
authors.initials: K
authors.lastname: Oztarhan
authors.affiliation: Department of Haemotology and Oncology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
authors.forename: Muge
authors.initials: M
authors.lastname: Gokce
authors.affiliation: Department of Neonatology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
authors.forename: Merih
authors.initials: M
authors.lastname: Cetinkaya
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology; D002176:Candida albicans / Q000254:growth & development / Q000302:isolation & purification*; D058365:Candidiasis, Invasive / Q000188:drug therapy* / Q000382:microbiology; D004452:Echocardiography; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006321:Heart / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000382:microbiology*; D019102:Infant, Very Low Birth Weight; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: Candida albicans; fungal endocarditis; prematurity; recombinant tissue activator