title: Mild Approach to 2-Acylfurans via Intercepted Meyer-Schuster Rearrangement of 6-Hydroxyhex-2-en-4-ynals.
abstract: We have developed a mild, intramolecular intercepted Meyer-Schuster (M-S) rearrangement for the synthesis of 2-acylfurans from corresponding cis-6-hydroxyhex-2-en-4-ynals. This reaction was found to be very general, and the starting materials are easily accessible. By this methodology the first synthesis of deoxy-nor-abiesesquine B, a sesquiterpene, was also achieved in three steps. The concept of adding two nucleophiles during the M-S rearrangement was introduced.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India.
authors.forename: Prabhakararao
authors.initials: P
authors.lastname: Tharra
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India.
authors.forename: Beeraiah
authors.initials: B
authors.lastname: Baire