title: Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells.
abstract: Neuritin is a neurotrophic factor associated with neuroplasticity. Most studies on neuritin focus on the nervous system; however, there has been no comprehensive evaluation of neuritin in non-neuronal cells. In this study, we screened 11 cell lines and found that neuritin was not expressed in bone marrowderived mesenchymal stem cells (BMSCs). Neuritin-expressing BMSCs were obtained by transfection. In the neuritin-expressing BMSC model, we observed significantly greater cell migration and improved anti-senescence protection, in addition to reduced proliferation and viability. In conclusion, neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells. This study provides a theoretical basis for understanding the function of neuritin.
authors.forename: Xuhui
authors.initials: X
authors.lastname: Wang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Liu
authors.forename: Fen
authors.initials: F
authors.lastname: Xu
authors.forename: Lijuan
authors.initials: L
authors.lastname: Cui
authors.forename: Siwei
authors.initials: S
authors.lastname: Tan
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
mesh_terms: D015153:Blotting, Western; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D002470:Cell Survival / Q000235:genetics; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000235:genetics*; D058851:GPI-Linked Proteins / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D007150:Immunohistochemistry; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D009479:Neuropeptides / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D058851:GPI-Linked Proteins; C484539:NRN1 protein, human; D009479:Neuropeptides