title: Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review.
abstract: Carbazoles represent an important class of heterocycles. These have been reported to exhibit diverse biological activities such as antimicrobial, antitumor, antiepileptic, antihistaminic, antioxidative, anti-inflammatory, antidiarrhoeal, analgesic, neuroprotective and pancreatic lipase inhibition properties. A series of carbazole derivatives such as N-substituted carbazoles, benzocarbazoles, furocarbazoles, pyrrolocarbazoles, indolocarbazoles, imidazocarbazoles, etc. have been synthesized. The N-substituted derivatives have gained the attention of researchers due to their therapeutic potential against neurological disorders and cell proliferation. Herein an attempt is made to review the medicinal importance of recently synthesized N-substituted carbazoles.
authors.affiliation: Department of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan. marach13@hotmail.com.
authors.forename: Maryam
authors.initials: M
authors.lastname: Bashir
authors.affiliation: Department of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan. afifa28mc@gmail.com.
authors.forename: Afifa
authors.initials: A
authors.lastname: Bano
authors.affiliation: Department of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan. abdulsubhan@bzu.edu.pk.
authors.forename: Abdul Subhan
authors.initials: AS
authors.lastname: Ijaz
authors.affiliation: Department of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan. drbashirahmadch@bzu.edu.pk.
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Chaudhary
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D002227:Carbazoles / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D002227:Carbazoles; D018696:Neuroprotective Agents
keywords: N-substituted carbazoles; anticancer; antimicrobial; neuroprotective