title: Alzheimer's disease and modern lifestyle: what is the role of stress?
abstract: This Editorial highlights a study by Baglietto-Vargas et al. 2015 published in this issue of J. Neurochem. Stress is one of the environmental factors that can contribute to Alzheimer's disease pathogenesis. However, the role of modern-life stress has not been investigated yet. The authors reveal that modern-life stress reduces the number of dendritic spines in the hippocampus of Alzheimer's disease transgenic mice. The mechanism underlying such effect involves an increase in corticotropin-releasing hormone (CRH) release that stimulates the amyloid precursor protein (APP) processing and fosters the generation of Amyloid-β, which negatively affects dendritic spines.
authors.affiliation: Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Marcello
authors.affiliation: Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gardoni
authors.affiliation: Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Di Luca
mesh_terms: D000544:Alzheimer Disease / Q000523:psychology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008297:Male; D009622:Noise / Q000009:adverse effects*; D013315:Stress, Psychological / Q000150:complications*; D014732:Vibration / Q000009:adverse effects*
chemical_list: D016229:Amyloid beta-Peptides