title: A bioinspired catalytic aerobic oxidative C-H functionalization of primary aliphatic amines: synthesis of 1,2-disubstituted benzimidazoles.
abstract: Aerobic oxidative CH functionalization of primary aliphatic amines has been accomplished with a biomimetic cooperative catalytic system to furnish 1,2-disubstituted benzimidazoles that play an important role as drug discovery targets. This one-pot atom-economical multistep process, which proceeds under mild conditions, with ambient air and equimolar amounts of each coupling partner, constitutes a convenient environmentally friendly strategy to functionalize non-activated aliphatic amines that remain challenging substrates for non-enzymatic catalytic aerobic systems.
authors.affiliation: UMR 8638 CNRS-Université Paris Descartes (Paris 5), Sorbonne Paris Cité, Faculté de Pharmacie de Paris, 4 avenue de l'Observatoire, 75270 Paris cedex 06 (France).
authors.forename: Khac Minh Huy
authors.initials: KM
authors.lastname: Nguyen
authors.affiliation: UMR 8638 CNRS-Université Paris Descartes (Paris 5), Sorbonne Paris Cité, Faculté de Pharmacie de Paris, 4 avenue de l'Observatoire, 75270 Paris cedex 06 (France). martine.largeron@parisdescartes.fr.
authors.forename: Martine
authors.initials: M
authors.lastname: Largeron
mesh_terms: D000588:Amines / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D032701:Biomimetics; D002384:Catalysis; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000588:Amines; D001562:Benzimidazoles
keywords: CH functionalization; aerobic oxidation; amines; benzimidazoles; homogeneous catalysis