title: Application of CPPs for Brain Delivery.
abstract: Cell-penetrating peptides provide a promising strategy for delivery of drugs across the blood-brain barrier. Here, we present an overview of CPP and peptide-mediated delivery to the central nervous system as well as a Transwell in vitro model to evaluate passage across an endothelial cell layer mimic of the blood-brain barrier.
authors.affiliation: Department of Neurochemistry, Stockholm University, S.Arrheniusv. 16B, SE-106 91, Stockholm, Sweden, artita.srimanee@neurochem.su.se.
authors.forename: Artita
authors.initials: A
authors.lastname: Srimanee
authors.forename: Jakob
authors.initials: J
authors.lastname: Regberg
authors.forename: Ülo
authors.initials: Ü
authors.lastname: Langel
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics; D004867:Equipment Design; D018014:Gene Transfer Techniques; D005910:Glioma / Q000378:metabolism; D006801:Humans; D008156:Luciferases / Q000032:analysis / Q000235:genetics; D008163:Luminescent Measurements / Q000379:methods; D010957:Plasmids / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics
chemical_list: D057846:Cell-Penetrating Peptides; D004247:DNA; D008156:Luciferases