title: A prospective randomized trial comparing the clinical effectiveness and biocompatibility of heparin-coated circuits and PMEA-coated circuits in pediatric cardiopulmonary bypass.
abstract: OBJECTIVE
  We compared the clinical effectiveness and biocompatibility of poly-2-methoxyethyl acrylate (PMEA)-coated and heparin-coated cardiopulmonary bypass (CPB) circuits in a prospective pediatric trial.
  
  
  METHODS
  Infants randomly received heparin-coated (n=7) or PMEA-coated (n=7) circuits in elective pediatric cardiac surgery with CPB for ventricular septum defects. Clinical and hematologic variables, respiratory indices and hemodynamic changes were analyzed perioperatively.
  
  
  RESULTS
  Demographic and clinical variables were similar in both groups. Leukocyte counts were significantly lower 5 minutes after CPB in the PMEA group than the heparin group. Hemodynamic data showed that PMEA caused hypotension within 5 minutes of CPB. The respiratory index was significantly higher immediately after CPB and 1 hour after transfer to the intensive care unit (ICU) in the PMEA group, as were levels of C-reactive protein 24 hours after transfer to the ICU.
  
  
  CONCLUSIONS
  Our study shows that PMEA-coated circuits, unlike heparin-coated circuits, cause transient leukopenia during pediatric CPB and, perhaps, systemic inflammatory respiratory syndrome after pediatric CPB.
authors.affiliation: Department of Medical Engineering, Faculty of Health Sciences, Junshin Gakuen University, Fukuoka, Japan Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan itoh.h@junshin-u.ac.jp.
authors.forename: Hideshi
authors.initials: H
authors.lastname: Itoh
authors.affiliation: Department of Community and Emergency Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Ichiba
authors.affiliation: Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Ujike
authors.affiliation: Department of Cardiovascular Surgery, Okayama University Hospital, Okayama, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Douguchi
authors.affiliation: Department of Cardiovascular Surgery, Okayama University Hospital, Okayama, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kasahara
authors.affiliation: Department of Cardiovascular Surgery, Okayama University Hospital, Okayama, Japan.
authors.forename: Sadahiko
authors.initials: S
authors.lastname: Arai
authors.affiliation: Department of Cardiovascular Surgery, Okayama University Hospital, Okayama, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Sano
mesh_terms: D000179:Acrylates; D006348:Cardiac Surgical Procedures / Q000295:instrumentation* / Q000379:methods*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation* / Q000379:methods*; D020099:Coated Materials, Biocompatible; D005260:Female; D006493:Heparin; D006801:Humans; D007223:Infant; D008297:Male; D011108:Polymers; D011446:Prospective Studies
chemical_list: D000179:Acrylates; D020099:Coated Materials, Biocompatible; D011108:Polymers; C413485:poly(2-methoxyethylacrylate); D006493:Heparin
keywords: PMEA coating; cardiopulmonary bypass; heparin coating; pediatric; transient leukopenia