title: The promises of neurodegenerative disease modeling.
abstract: The rise in the prevalence of neurodegenerative diseases parallels the rapid increase in human lifespan. Despite intensive research, the molecular and cellular mechanisms underlying the onset and progression of these devastating diseases with age are still poorly understood. Many aspects of these diseases have been modelled successfully in experimental animals such as the mouse, the zebrafish Brachydanio rero, the nematode worm Caenorhaditis elegans and the fruit fly Drosophila melanogaster. This review will focus on the advantages offered by the genetic tools available in Drosophila for combining powerful strategies in order to tackle the causative factors of these complex pathologies and help to elaborate efficient drugs to treat them.
authors.affiliation: Institut Jacques-Monod, CNRS UMR 7592, Université Paris-Diderot, 15, rue Hélène-Brion, 75205 Paris cedex 13, France. Electronic address: lepesant.jean-antoine@ijm.univ-paris-diderot.fr.
authors.forename: Jean-Antoine
authors.initials: JA
authors.lastname: Lepesant
mesh_terms: D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D004331:Drosophila melanogaster; D015195:Drug Design; D006801:Humans; D019636:Neurodegenerative Diseases / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D015995:Prevalence
keywords: Animal models; Drosophila melanogaster; Modèles animaux; Neurodegeneration; Neurodégénération