title: Advances in hepatitis C therapies.
abstract: BACKGROUND
  The recent development of new direct acting antivirals constitutes a clinical revolution in the field of hepatitis C therapy. Different drugs with direct antiviral effects and very high potency have been developed, changing the current scenario and prognosis of hepatitis C-related liver disease. This review aims to clarify the current stage of the different antiviral strategies in patients with chronic hepatitis C infection by analyzing the specific efficacy of each combination.
  
  
  METHODS
  Data have been extracted from the most important published clinical trials, cumulative real-world experience reports and data from the most relevant studies presented in the last international meetings (European and American International Liver Congresses). In addition, data from the recently updated international guidelines have also been included.
  
  
  CONCLUSIONS
  Although there are many differences in health-care budgets among countries in the world which will surely compromise drug availability and treatment decisions, this review aims to give a general and brief recommendation to help treating physicians to choose the best option to treat hepatitis C.
authors.affiliation: Liver Unit, Hospital Clinic, University of Barcelona, CIBERehd, IDIBAPS , C/Villarroel 170, 08036 Barcelona , Spain +1 34 93 2275400 ; xforns@clinic.ub.es.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Mariño
authors.forename: Sabela
authors.initials: S
authors.lastname: Lens
authors.forename: Martina
authors.initials: M
authors.lastname: Gambato
authors.forename: Xavier
authors.initials: X
authors.lastname: Forns
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002219:Carbamates; D060085:Coinfection; D004359:Drug Therapy, Combination; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D019698:Hepatitis C, Chronic / Q000188:drug therapy; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D016030:Kidney Transplantation; D016031:Liver Transplantation; D011759:Pyrrolidines; D000069616:Simeprevir / Q000627:therapeutic use; D000069474:Sofosbuvir / Q000627:therapeutic use; D014633:Valine / Q000031:analogs & derivatives
chemical_list: D000998:Antiviral Agents; D002219:Carbamates; D007093:Imidazoles; D011759:Pyrrolidines; D000069616:Simeprevir; D014633:Valine; C549273:daclatasvir; D000069474:Sofosbuvir
keywords: direct acting antivirals; hepatitis C; interferon-free combinations