title: Biotechnological approaches to enhance salidroside, rosin and its derivatives production in selectedRhodiolaspp. in vitro cultures.
abstract: Rhodiola(Crassulaceae) an arctic-alpine plant, is extensively used in traditional folk medicine in Asian and European countries. A number of investigations have demonstrated thatRhodiolapreparations exhibit adaptogenic, neuroprotective, anti-tumour, cardioprotective, and anti-depressant effects. The main compounds responsible for these activities are believed to be salidroside, rosin and its derivatives which became the target of biotechnological investigations. This review summarizes the results of the diverse biotechnological approaches undertaken to enhance the production of salidroside, rosin and its derivatives in callus, cell suspension and organ in vitro cultures of selectedRhodiolaspecies.
authors.affiliation: Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 St., 02-097 Warsaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Grech-Baran
authors.affiliation: Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 St., 02-097 Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sykłowska-Baranek
authors.affiliation: Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 St., 02-097 Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Pietrosiuk
keywords: Biotransformation; In vitro cultures; Rhodiola spp.; Rosin derivatives; Salidroside