title: Electrochemical analysis of a novel ferrocene derivative as a potential antitumor drug.
abstract: Ferrocenes represent an interesting group of drugs with potential antitumor properties. Moreover, their electronic properties make them suitable for electrochemical studies. We determined an uptake of a novel ferrocene derivative in low μM concentrations by selected cancer cell lines and showed its localization predominantly in cytoplasm, using glassy carbon electrodes.
authors.affiliation: RECAMO, Masaryk Memorial Cancer Institute, Žlutý kopec 7, 656 53 Brno, Czech Republic. hrstka@mou.cz.
authors.forename: M
authors.initials: M
authors.lastname: Bartošík
authors.forename: L
authors.initials: L
authors.lastname: Koubková
authors.forename: J
authors.initials: J
authors.lastname: Karban
authors.forename: L
authors.initials: L
authors.lastname: Červenková Šťastná
authors.forename: T
authors.initials: T
authors.lastname: Hodík
authors.forename: M
authors.initials: M
authors.lastname: Lamač
authors.forename: J
authors.initials: J
authors.lastname: Pinkas
authors.forename: R
authors.initials: R
authors.lastname: Hrstka
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D055664:Electrochemical Techniques; D004566:Electrodes; D005296:Ferrous Compounds / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D000075163:Metallocenes; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D005296:Ferrous Compounds; D000075163:Metallocenes; D017382:Reactive Oxygen Species; C004998:ferrocene