title: Cystochromones, Unusual Chromone-Containing Polyketides from the Myxobacterium Cystobacter sp. MCy9104.
abstract: Seven new chromone-containing polyketides, termed cystochromones A-G, were isolated from the myxobacterial strain Cystobacter sp. MCy9104. Their structures were elucidated using comprehensive NMR spectroscopy and HR-MS/MS. Cystochromones bear a pentadecyl moiety unusually attached at C-5 of the chromone ring. Moreover, isotope-labeled substrate feeding experiments and NMR analysis suggested a hybrid iso-fatty acid and polyketide synthase biosynthetic pathway for these secondary metabolites.
authors.affiliation: Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Pharmaceutical Biotechnology, Saarland University , Campus C2 3, 66123 Saarbrücken, Germany.|German Center for Infection Research (DZIF) , Partner site Hannover-Braunschweig 38124 Hannover-Braunschweig, Germany.
authors.forename: Suvd
authors.initials: S
authors.lastname: Nadmid
authors.affiliation: Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Pharmaceutical Biotechnology, Saarland University , Campus C2 3, 66123 Saarbrücken, Germany.|German Center for Infection Research (DZIF) , Partner site Hannover-Braunschweig 38124 Hannover-Braunschweig, Germany.
authors.forename: Alberto
authors.initials: A
authors.lastname: Plaza
authors.affiliation: Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Pharmaceutical Biotechnology, Saarland University , Campus C2 3, 66123 Saarbrücken, Germany.|German Center for Infection Research (DZIF) , Partner site Hannover-Braunschweig 38124 Hannover-Braunschweig, Germany.
authors.forename: Ronald
authors.initials: R
authors.lastname: Garcia
authors.affiliation: Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Pharmaceutical Biotechnology, Saarland University , Campus C2 3, 66123 Saarbrücken, Germany.|German Center for Infection Research (DZIF) , Partner site Hannover-Braunschweig 38124 Hannover-Braunschweig, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
mesh_terms: D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification*; D007553:Isotope Labeling; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D048630:Polyketide Synthases / Q000378:metabolism; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D002867:Chromones; D061065:Polyketides; C000603010:cystochromone A; D048630:Polyketide Synthases