title: Antiadenovirus drug discovery: potential targets and evaluation methodologies.
abstract: Human adenoviruses (HAdV) are the cause of many acute infections, mostly in the respiratory and gastrointestinal (GI) tracts, as well as conjunctivitis. HAdV diseases in immunocompetent individuals are mostly self-limiting; however, in immunocompromised individuals, especially in pediatric units, HAdV infections are the cause of high morbidity and mortality. Despite the significant clinical impact, there are currently no approved antiviral therapies for HAdV infections. Here, we provide an overview of the different targets that could be considered for the design of specific drugs against HAdV, as well as the available in vitro and in vivo tools for the screening and evaluation of candidate molecules.
authors.affiliation: Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Seville, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Martínez-Aguado
authors.affiliation: Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Seville, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Serna-Gallego
authors.affiliation: Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Seville, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Marrugal-Lorenzo
authors.affiliation: Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Seville, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Gómez-Marín
authors.affiliation: Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Seville, Spain. Electronic address: jsanchez-ibis@us.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-Céspedes
mesh_terms: D000258:Adenovirus Infections, Human / Q000188:drug therapy* / Q000821:virology; D000260:Adenoviruses, Human / Q000302:isolation & purification; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D015195:Drug Design; D055808:Drug Discovery; D006801:Humans; D016867:Immunocompromised Host; D058990:Molecular Targeted Therapy
chemical_list: D000998:Antiviral Agents