title: Neuroprotective and Antioxidant Effects of Neuroglutam in Cerebral Ischemia.
abstract: We studied in vitro and in vivo neuroprotective and antioxidant properties of neuroglutam, a new glutamic acid derivative. In experiments on immortalized mouse hippocampal cell line HT22, neuroglutam exhibited a neuroprotective effect in the model of oxidative stress after its introduction, both before and after H2O2. In vivo study on animals treated with neuroglutam against the background of cerebral ischemia modeled by irreversible occlusion of the common carotid arteries showed that plasma level of TBA-active products was significantly lower and activities of cell antioxidant enzymes (superoxide dismutase and catalase) were higher than in control animals receiving saline under the same conditions.
authors.affiliation: Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.forename: E V
authors.initials: EV
authors.lastname: Volotova
authors.forename: D V
authors.initials: DV
authors.lastname: Kurkin
authors.forename: N V
authors.initials: NV
authors.lastname: Mazina
authors.forename: D A
authors.initials: DA
authors.lastname: Bakulin
authors.forename: I O
authors.initials: IO
authors.lastname: Logvinov
authors.forename: T A
authors.initials: TA
authors.lastname: Antipova
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy*; D002460:Cell Line; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants; D018698:Glutamic Acid; D006861:Hydrogen Peroxide