title: Multicomponent Coupling Reaction Using Arynes: Synthesis of Xanthene Derivatives.
abstract: One-pot synthesis of xanthene derivatives was achieved by a route involving the cascade three-component coupling reaction of arynes with DMF and active methylenes followed by the SN2' reaction of three-component coupling products with thiols. The reactivity of three-component coupling products toward nucleophiles and the further conversion of oxygen heterocycles allowing facile incorporation of structural variety were studied.
authors.affiliation: School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Kobe 650-8530, Japan.
authors.forename: Eito
authors.initials: E
authors.lastname: Yoshioka
authors.affiliation: School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Kobe 650-8530, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Nishimura
authors.affiliation: School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Kobe 650-8530, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakazawa
authors.affiliation: School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Kobe 650-8530, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohtani
authors.affiliation: School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Kobe 650-8530, Japan.
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyabe
mesh_terms: D002384:Catalysis; D003500:Cyclization; D004126:Dimethylformamide / Q000737:chemistry*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013438:Sulfhydryl Compounds; D014966:Xanthenes; D010165:Palladium; D004126:Dimethylformamide; D010100:Oxygen