title: A meta-analysis of the response of pathological hoarding to pharmacotherapy.
abstract: This meta-analysis aimed to identify all studies that have assessed treatment response for pathological hoarding treated with pharmacological agents. Seven studies were identified with a total of 92 participants. Most participants had a diagnosis of obsessive-compulsive disorder. Studies assessed response to serotonin-reuptake inhibitors (SRIs); venlafaxine; methylphenidate; and augmentation of SRIs with quetiapine, minocycline and naltrexone. More than half (ER=0.58, 95% CI=0.37-0.76) of the participants treated with pharmacotherapy responded. This study encourages us to consider the use of SRIs in patients with hoarding disorder. The study also encourages more studies of pharmacotherapy for pathological hoarding, noting that these studies should use validated outcome measures that specifically assess pathological hoarding and novel agents that target the unique neurobiological correlates of pathological hoarding.
authors.affiliation: Discipline of Psychiatry, The University of Sydney, Sydney Medical School - Nepean, Penrith, New South Wales, Australia. Electronic address: vlasios.brakoulias@sydney.edu.au.
authors.forename: Vlasios
authors.initials: V
authors.lastname: Brakoulias
authors.affiliation: The Whiteley-Martin Research Centre, The Discipline of Surgery, The University of Sydney, Sydney Medical School - Nepean, Penrith, New South Wales, Australia.
authors.forename: Guy D
authors.initials: GD
authors.lastname: Eslick
authors.affiliation: Discipline of Psychiatry, The University of Sydney, Sydney Medical School - Nepean, Penrith, New South Wales, Australia.
authors.forename: Vladan
authors.initials: V
authors.lastname: Starcevic
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D000067836:Hoarding Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008774:Methylphenidate / Q000627:therapeutic use; D008911:Minocycline / Q000627:therapeutic use; D009271:Naltrexone / Q000627:therapeutic use; D000069348:Quetiapine Fumarate / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D000069470:Venlafaxine Hydrochloride / Q000627:therapeutic use
chemical_list: D008774:Methylphenidate; D008911:Minocycline; D009271:Naltrexone; D000069348:Quetiapine Fumarate; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride
keywords: Drug therapy; Hoarding disorder; Medication; Obsessive-compulsive and related disorders