title: Maternal circulating levels of some metabolic syndrome biomarkers in gestational diabetes mellitus.
abstract: The aims of the present study were to explore serum levels of lipid profile, atherogenic indexes LDL-C/HDL-C, TG/HDL-C, and TC/HDL-C, bilirubin, adiponectin, pseudocholinesterase, activities of gamma-glutamyltransferase (GGT), adenosine deaminase (ADA), and α-amylase, insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR) formula, and assessment of correlations between them in gestational diabetes mellitus (GDM) compared with normal pregnancy. A cross-sectional study was designed. The patients consisted of 30 women with GDM. The normal group consisted of 30 healthy pregnant women. The Mann-Whitney U test and Spearman's correlation analysis were used for statistical analysis. A p value less than 0.05 was considered significant. Serum activities of enzymes GGT (p = 0.001) and ADA (p = 0.02) were significantly higher in GDM compared with normal pregnancy, while pseudocholinesterase were significantly decreased (p = 0.02). However, activity of enzyme α-amylase did not show significant difference between two groups (p = 0.75). Serum levels of both HDL-C and adiponectin were significantly decreased in GDM group (p = 0.001). The atherogenic indexes and the HOMA-IR index were significantly higher in GDM (p = 0.001). Serum activity of ADA showed positive correlation with total cholesterol (TC) (r = 0.46, p = 0.01) and CRP (r = 0.66, p = 0.001) in GDM group. Serum levels of total bilirubin correlated negatively with both ADA (r = -0.38, p = 0.04) and triglyceride (r = -0.45, p = 0.01) in women with GDM. Serum activity of GGT correlated positively with LDL-C (r = 0.48, p = 0.01) and TC (r = 0.52, p = 0.003) in GDM group. Increased atherogenic indexes, ADA, GGT, and decreased pseudocholinesterase might be risk factors for GDM.
authors.affiliation: School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. khosrowbeygi@yahoo.com.|Department of Biochemistry, School of Medicine, Arak University of Medical Sciences, Arak, Iran. khosrowbeygi@yahoo.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Khosrowbeygi
authors.affiliation: School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Shiamizadeh
authors.affiliation: School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Taghizadeh
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood*; D011247:Pregnancy; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D005723:gamma-Glutamyltransferase; D001663:Bilirubin
keywords: Adenosine deaminase; Amylase; Atherogenic index; Gamma-glutamyltransferase; Gestational diabetes mellitus; Insulin resistance