title: Do Leukocyte and Platelet Counts Have Benefit for \Preoperative Evaluation of Endometrial Cancer?
abstract: OBJECTIVE
  The aim of this study was to investigate the association between preoperative leukocyte and platelet counts and the stage of the disease in patients with endometrial cancer.
  
  
  METHODS
  Data for 100 patients undergoing total abdominal hysterectomy and bilateral salpingoophorectomy for benign uterine diseases and 177 patients surgically staged for endometrial cancer at Ondokuz Mayis University, Department of Gynecology and Obstetrics between 2005 and 2013, with preoperative complete blood count in the week prior to surgery including WBC, platelet count, pathologic evaluation for both benign and malign endometrium lesions, tumor stage and presence of lymphovascular space invasion (LVI), were retrospectively analyzed.
  
  
  RESULTS
  The preoperative leukocyte count was significantly higher in patients with endometrial cancer when compared to the patients with benign diseases. However, there were no significant differences in platelet counts between the groups. Patients with advanced stage endometrial cancer had higher preoperative leukocyte counts when compared to the early stage disease whereas there was no difference in platelet count. Multivariate regression analysis identified preoperative leukocytosis as an independent prognostic factor for endometrial cancer. The optimal cut-off point for WBC was calculated as 10,500 to differentiate stage 1-2-3 and 4 with 88.9% sensitivity and 86.3% specificity (AUC: 0.901, 95% CI: 0.829-0.973, p<0.001, PPV: 25.8%, NPV: 99.3%).
  
  
  CONCLUSIONS
  Preoperative leukocytosis is independently associated with advanced endometrial cancer.
authors.affiliation: Kackar State Hospital, Rize, Turkey E-mail : emel0022@mynet.com.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ekici
authors.forename: Erdal
authors.initials: E
authors.lastname: Malatyalioglu
authors.forename: Arif
authors.initials: A
authors.lastname: Kokcu
authors.forename: Emel
authors.initials: E
authors.lastname: Kurtoglu
authors.forename: Migraci
authors.initials: M
authors.lastname: Tosun
authors.forename: Handan
authors.initials: H
authors.lastname: Celik
mesh_terms: D001792:Blood Platelets / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D007962:Leukocytes / Q000473:pathology*; D007964:Leukocytosis / Q000453:epidemiology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013922:Thrombocytosis / Q000453:epidemiology*; D014421:Turkey / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery