title: Results of a Multicenter Phase II Trial of Brentuximab Vedotin as Second-Line Therapy before Autologous Transplantation in Relapsed/Refractory Hodgkin Lymphoma.
abstract: This multicenter prospective phase II study examines the activity and tolerability of brentuximab vedotin as second-line therapy in patients with Hodgkin lymphoma that was relapsed or refractory after induction therapy. Brentuximab vedotin (1.8 mg/kg) was administered i.v. on day 1 of a 21-day cycle for a total of 4 cycles. Patients then proceeded to autologous hematopoietic cell transplantation (AHCT), if eligible, with or without additional salvage therapy, based on remission status after brentuximab vedotin. The primary endpoint was overall response rate (ORR). Secondary endpoints were safety, stem cell mobilization/collection, AHCT outcomes, and association of CD68(+) with outcomes. Of 37 patients, the ORR was 68% (13 complete remission, 12 partial remission). The regimen was well tolerated with few grade 3/4 adverse events, including lymphopenia (1), neutropenia (3), rash (2), and hyperuricemia (1). Thirty-two patients (86%) were able to proceed to AHCT, with 24 patients (65%) in complete remission at time of AHCT. Thirteen patients in complete remission, 4 in partial remission, and 1 with stable disease (49%) received AHCT without salvage combination chemotherapy. CD68 expression did not correlate with response to brentuximab vedotin. The median number of stem cells mobilized was 6.0 × 10(6) (range, 2.6 to 34), and median number of days to obtain minimum collection (2 × 10(6)) was 2 (range, 1 to 6). Brentuximab vedotin as second-line therapy is active, well tolerated, and allows adequate stem cell collection and engraftment. For Hodgkin lymphoma patients with relapsed/refractory disease after induction therapy, second-line brentuximab vedotin, followed by combination chemotherapy for residual disease, can effectively bridge patients to AHCT.
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, California. Electronic address: rwc755@gmail.com.
authors.forename: Robert
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Information Sciences, Division of Biostatistics, City of Hope, Duarte, California.
authors.forename: Joycelynne M
authors.initials: JM
authors.lastname: Palmer
authors.affiliation: Department of Hematology/Oncology, Weill Cornell Medical College, New York, New York.
authors.forename: Peter
authors.initials: P
authors.lastname: Martin
authors.affiliation: Department of Information Sciences, Division of Biostatistics, City of Hope, Duarte, California.
authors.forename: Nicole
authors.initials: N
authors.lastname: Tsai
authors.affiliation: Department Pathology, City of Hope, Duarte, California.
authors.forename: Young
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department Diagnostic Radiology, City of Hope, Duarte, California.
authors.forename: Bihong T
authors.initials: BT
authors.lastname: Chen
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
authors.forename: Leslie
authors.initials: L
authors.lastname: Popplewell
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
authors.forename: Tanya
authors.initials: T
authors.lastname: Siddiqi
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
authors.forename: Sandra H
authors.initials: SH
authors.lastname: Thomas
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
authors.forename: Michelle
authors.initials: M
authors.lastname: Mott
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, and Kaiser Permanente, Los Angeles, California.
authors.forename: Firoozeh
authors.initials: F
authors.lastname: Sahebi
authors.affiliation: Department of Population Sciences, City of Hope, Duarte, California.
authors.forename: Saro
authors.initials: S
authors.lastname: Armenian
authors.affiliation: Department of Hematology/Oncology, Weill Cornell Medical College, New York, New York.
authors.forename: John
authors.initials: J
authors.lastname: Leonard
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
authors.forename: Auayporn
authors.initials: A
authors.lastname: Nademanee
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Forman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D000079963:Brentuximab Vedotin; D002648:Child; D004334:Drug Administration Schedule; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology / Q000473:pathology; D018796:Immunoconjugates / Q000008:administration & dosage* / Q000009:adverse effects; D008231:Lymphopenia / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology / Q000473:pathology; D011446:Prospective Studies; D012008:Recurrence; D012074:Remission Induction; D016879:Salvage Therapy; D016019:Survival Analysis; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D018796:Immunoconjugates; D000079963:Brentuximab Vedotin
keywords: Autologous hematopoietic transplantation; Brentuximab vedotin; Hodgkin lymphoma; Salvage