title: Protective Role of Oleuropein against Acute Deltamethrin-Induced Neurotoxicity in Rat Brain.
abstract: BACKGROUND
  Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex.
  
  
  METHODS
  Rats were randomly divided into four groups each containing five rats: DM-treated group (12.5 mg/kg, a single dose), OE-treated group (20 mg/kg per day), DM + OE-treated group, and vehicle group. Sections of the brain were obtained 24 hours after DM injection and studied for histopathological and immunohistochemistry assessment.
  
  
  RESULTS
  The histopathological assessments showed lesser characteristics of neural degeneration in DM + OE group compared with DM group. Greater Bcl-2 and attenuated Bax expression could be detected in the DM + OE treated-mice compared with DM group.
  
  
  CONCLUSIONS
  The results suggested that DM-induced neurotoxicity can be subsided by OE.
authors.affiliation: Molecular and Cell Biology Research Center, Dept. of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Khalatbary
authors.affiliation: Dept. of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Elmira
authors.initials: E
authors.lastname: Ghaffari
authors.affiliation: Dept. of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Behrooz
authors.initials: B
authors.lastname: Mohammadnegad
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002540:Cerebral Cortex / Q000166:cytology / Q000473:pathology*; D005260:Female; D007306:Insecticides / Q000009:adverse effects*; D057888:Iridoid Glucosides; D039823:Iridoids / Q000627:therapeutic use*; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000517:prevention & control; D009498:Neurotoxins / Q000009:adverse effects; D009570:Nitriles / Q000009:adverse effects*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D011722:Pyrethrins / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis
chemical_list: D007306:Insecticides; D057888:Iridoid Glucosides; D039823:Iridoids; D018696:Neuroprotective Agents; D009498:Neurotoxins; D009570:Nitriles; D019253:Proto-Oncogene Proteins c-bcl-2; D011722:Pyrethrins; D051028:bcl-2-Associated X Protein; C017180:decamethrin; C002769:oleuropein
keywords: Apoptosis; Deltamethrin; Oleuropein