title: Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations.
abstract: BACKGROUND
  Renal transplant recipients (RTRs) have an increased risk of developing nonmelanoma skin cancer, mainly cutaneous squamous cell carcinoma (cSCC). Two genes (TMC6/EVER1 and TMC8/EVER2), mutated in epidermodysplasia verruciformis (EV) patients with an increased risk of cSCC development, contain numerous single-nucleotide polymorphisms (SNPs).
  
  
  OBJECTIVE
  To evaluate the effect of SNPs in both TMC/EVER genes on the different susceptibilities of RTRs to cSCC.
  
  
  METHODS
  We determined the occurrence of cSCC in 105 RTRs who were transplanted at least 7 years previously and investigated the frequency of 26 SNPs within both TMC/EVER genes in severely affected (n = 16) as well as in nonaffected RTRs (n = 25).
  
  
  RESULTS
  Our data did not indicate a significant association between any SNP genotype and risk of cSCC development in RTRs.
  
  
  CONCLUSIONS
  To clarify the correlation between SNPs in both TMC genes and cSCC development in RTRs, integrated investigations of large cohorts including both RTRs and immunocompetent individuals with consideration of cSCC status, SNP genotype and human papillomavirus status might be necessary.
authors.affiliation: Research Group of Dermatology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
authors.forename: Bettina
authors.initials: B
authors.lastname: Burger
authors.forename: Iris
authors.initials: I
authors.lastname: Spörri
authors.forename: Danielle A
authors.initials: DA
authors.lastname: Stegmann
authors.forename: Julie
authors.initials: J
authors.lastname: De Mesmaker
authors.forename: Stefan
authors.initials: S
authors.lastname: Schaub
authors.forename: Peter H
authors.initials: PH
authors.lastname: Itin
authors.forename: Jürg
authors.initials: J
authors.lastname: Steiger
authors.forename: Andreas W
authors.initials: AW
authors.lastname: Arnold
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism; D066027:Transplant Recipients
chemical_list: D004273:DNA, Neoplasm; D008565:Membrane Proteins; C470314:TMC6 protein, human; C470315:TMC8 protein, human