title: Triadin regulation of the ryanodine receptor complex.
abstract: The calcium release complex is the major player in excitation-contraction coupling, both in cardiac and skeletal muscle. The core of the complex is the ryanodine receptor, and triadin is a regulating protein. Nevertheless, the precise function of triadin is only partially understood. Besides its function in the anchoring of calsequestrin at the triad/dyad, our recent results allow us to propose hypotheses on new triadin scaffolding functions, based on the studies performed using different models, from triadin knockout mice to human patients, and expression in non-muscle cells, taking into account the presence of multiple triadin isoforms.
authors.affiliation: Grenoble Institut des Neurosciences, Inserm U836, Université Joseph Fourier-Bat EJ Safra, Chemin Fortuné Ferrini, 38700, La Tronche, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Marty
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002352:Carrier Proteins / Q000378:metabolism*; D003226:Congresses as Topic; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism*; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D009124:Muscle Proteins; D019837:Ryanodine Receptor Calcium Release Channel; C070048:triadin