title: The Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65years.
abstract: The more recent history and main experimental data for the Krushinsky-Molodkina (KM) audiogenic rat strain are presented. The strain selection started in late 1940. Now this strain is inbred, and two new strains are maintained in a laboratory in parallel. These strains originated from KM×Wistar hybrids and were bred (starting from 2000) for no-seizure and intense audiogenic seizure phenotypes, respectively. The experimental evidences of audiogenic seizure physiology were accumulated in parallel with (and usually ahead of) data on other audiogenic-prone strains. The peculiar feature of the KM strain is its vulnerability to brain hemorrhages. Thus, the KM strain is used not only as a genetic model of seizure states, but also as a model of blood flow disturbances in the brain. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".
authors.affiliation: Lomonossov Moscow State University, Biology Department, Laboratory for Physiology and Genetics of Behavior, Leninskie Gory, 1, Build. 12, Moscow 119992, Russia. Electronic address: ingapoletaeva@mail.ru.
authors.forename: I I
authors.initials: II
authors.lastname: Poletaeva
authors.affiliation: Lomonossov Moscow State University, Biology Department, Laboratory for Physiology and Genetics of Behavior, Leninskie Gory, 1, Build. 12, Moscow 119992, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Surina
authors.affiliation: Lomonossov Moscow State University, Biology Department, Laboratory for Physiology and Genetics of Behavior, Leninskie Gory, 1, Build. 12, Moscow 119992, Russia.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Kostina
authors.affiliation: Lomonossov Moscow State University, Biology Department, Laboratory for Physiology and Genetics of Behavior, Leninskie Gory, 1, Build. 12, Moscow 119992, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Perepelkina
authors.affiliation: Lomonossov Moscow State University, Biology Department, Laboratory for Physiology and Genetics of Behavior, Leninskie Gory, 1, Build. 12, Moscow 119992, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Fedotova
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects* / Q000379:methods; D000818:Animals; D001921:Brain / Q000503:physiopathology; D020195:Epilepsy, Reflex / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000235:genetics / Q000503:physiopathology; D013045:Species Specificity; D013997:Time Factors
keywords: Audiogenic seizure; Brain hemorrhage; Brain neurotransmitters; Epilepsy mechanisms; Inbred status; Oxidative stress; Rat strain