title: Clinical Outcomes of In Vitro Fertilization among Chinese Infertile Couples Treated for Syphilis Infection.
abstract: To compare the clinical outcomes of infertile patients with and without syphilis after in vitro fertilization and embryo transfer (IVF-ET), in this case-control study, 320 infertile couples were enrolled and divided into syphilis (n = 160) and control groups (n = 160). The primary IVF outcomes were the clinical pregnancy rate and the birth of a healthy baby. All syphilis patients received the standard anti-syphilis treatment before undergoing IVF/ICSI. Our results showed that the endometrial thickness of the syphilis group was greater than that of the control group following hCG injection (16.9±5.4 vs. 13.0±4.7 mm, P<0.001). The numbers of normally fertilized eggs and normally cleaved fertilized eggs and the implantation rate were 6.8±4.8, 6.3±4.7 and 24.2%, respectively, for the syphilis group and 8.3±4.6, 8.1±4.6 and 34.4%, respectively, for the control group, and these values were significantly different between the groups. The clinical pregnancy rate was lower in the syphilis group compared with that in the control group (43.8% vs. 55.6%, P = 0.03). Lower offspring birth weight was observed in the infected male group compared with those in the infected female (2.7±0.4 vs. 3.0±0.4 kg, P = 0.01) and infected couple groups (2.7±0.4 vs. 3.1±0.5 kg, P = 0.007). Therefore, syphilis infection reduces the clinical pregnancy rate after IVF/ICSI.
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Xi Road, Guangzhou 510120, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Xi Road, Guangzhou 510120, P. R. China.
authors.forename: Xiaomiao
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Xi Road, Guangzhou 510120, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yuan
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Xi Road, Guangzhou 510120, P. R. China.
authors.forename: Tingfeng
authors.initials: T
authors.lastname: Fang
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Xi Road, Guangzhou 510120, P. R. China.
authors.forename: Nengyong
authors.initials: N
authors.lastname: Ouyang
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Xi Road, Guangzhou 510120, P. R. China.
authors.forename: Ruiqi
authors.initials: R
authors.lastname: Li
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Xi Road, Guangzhou 510120, P. R. China.
authors.forename: Songbang
authors.initials: S
authors.lastname: Ou
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Xi Road, Guangzhou 510120, P. R. China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D002681:China; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007246:Infertility / Q000209:etiology / Q000628:therapy*; D008297:Male; D016017:Odds Ratio; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D013587:Syphilis / Q000150:complications*; D016896:Treatment Outcome