title: Prognostic Factors in Oligodendrogliomas: a Clinical Study of Twenty-Five Consecutive Patients.
abstract: BACKGROUND
  The purpose of this study was to evaluate the prognostic significance of Ki-67 and subjective microvascular density (SMVD) indexes together with other factors in patients with oligodendroglioma.
  
  
  METHODS
  In this retrospective study, oligodendroglioma specimens obtained from twenty-five consecutive patients were evaluated for Ki-67 and SMVD indices to help determine histological grading and investigate the fidelity of these markers in clinical prognosis. Other potentially prognostic factors were Karnofsky performance scale, tumor histological grade, and adjuvant radiotherapy.
  
  
  RESULTS
  The Ki-67 proliferation index appeared to have a strong correlation with the grade of the tumor and the survival. Age, gender, adjuvant radiotherapy, surgical resection type (complete versus incomplete) did not have any influence on recurrence. The SMVD index correlated significantly with the 3 to 5-year survival.
  
  
  CONCLUSIONS
  Ki-67 and MVD indexes are important and useful markers in estimating the prognosis of oligodendrogliomas.
authors.affiliation: Department of Neurosurgery, School of Medicine, Bozok University, Yozgat, Turkey E-mail : atalaytugay1970@hotmail.com.
authors.forename: Tugay
authors.initials: T
authors.lastname: Atalay
authors.forename: Hakan
authors.initials: H
authors.lastname: Ak
authors.forename: Bahattin
authors.initials: B
authors.lastname: Celik
authors.forename: Ismail
authors.initials: I
authors.lastname: Gulsen
authors.forename: Hakan
authors.initials: H
authors.lastname: Seckin
authors.forename: Nermin
authors.initials: N
authors.lastname: Tanik
authors.forename: Sedat Baki
authors.initials: SB
authors.lastname: Albayrak
authors.forename: Murad
authors.initials: M
authors.lastname: Bavbek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy; D009837:Oligodendroglioma / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000401:mortality*; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult