title: Progressive Multiple Cavernous Angiomas after Radiotherapy in a Pediatric Patient with Medulloblastoma: A Case Report.
abstract: BACKGROUND
  We report a case of progressive multiple cavernous angiomas.
  
  
  METHODS
  A 16-year-old boy presented with a 2-month history of headache and dizziness. Six years earlier, he underwent surgery for cerebellar medulloblastoma and subsequent chemoradiotherapy according to the M-051 protocol of the Korean Society of Pediatric Neuro-Oncology. Follow-up brain magnetic resonance imaging (MRI) revealed a tiny hemorrhage on the cerebellum 3 months after 23.4-Gy craniospinal and 32.4-Gy boost radiotherapy.
  
  
  RESULTS
  The multiple hemorrhagic lesions had progressively developed on the whole brain without any symptoms for 6 years. On admission, MRI revealed a 1.5-cm enlarged mass with subacute hemorrhage on the right frontal area. The mass was totally removed and diagnosed as cavernous angioma. However, 5 months later, the patient complained of a headache. MRI revealed 1.4- and 0.7-cm enlarged masses on the left frontal and right temporal areas with internal hemorrhage, respectively. The left frontal mass was totally removed, and the histopathological finding was suggestive of cavernous angioma.
  
  
  CONCLUSIONS
  This case showed early-developed multiple hemorrhagic lesions after radiotherapy, which had been progressive and were associated with some symptomatic cavernous angiomas. Pediatric patients with brain radiotherapy should undergo radiological check-up to identify vascular lesions, especially symptomatic patients.
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Chai
authors.forename: Tae-Young
authors.initials: TY
authors.lastname: Jung
authors.forename: Kyung-Hwa
authors.initials: KH
authors.lastname: Lee
authors.forename: Seul-Kee
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology* / Q000532:radiotherapy* / Q000601:surgery; D016371:Cranial Irradiation / Q000009:adverse effects* / Q000379:methods; D006392:Hemangioma, Cavernous / Q000209:etiology*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy* / Q000601:surgery