title: Comparison of conventional versus Hybrid knife peroral endoscopic myotomy methods for esophageal achalasia: a case-control study.
abstract: OBJECTIVE
  Peroral endoscopic myotomy (POEM) has been developed to treat achalasia as a novel less invasive modality. We aimed to compare the efficacy and safety of conventional knife versus Hybrid knife (HK) during POEM procedure.
  
  
  METHODS
  Between June 2012 and July 2014, 31 patients underwent POEM using HK in our department (HK group), and 36 patients underwent POEM using conventional method (injection needle and triangular tip [TT] knife, TT group). Procedure-related parameters, symptom relief, adverse events were compared between two groups.
  
  
  RESULTS
  There were no significant differences in the age, sex and other baseline characteristics between the two groups. The mean procedural time was significantly shorter in HK group than TT group (53.0 ± 17.2 vs. 67.6 ± 28.4 min, p = 0.015). The mean frequency of devices exchange was 4.7 ± 1.7 in HK group and 10.9 ± 1.8 in TT group (p = 0.000). No serious adverse events occurred postoperatively in both groups. At one-year follow-up, a total of 94% treatment success was achieved in all patients (93.5% in HK group and 94.4% in TT group, p = 0.877).
  
  
  CONCLUSIONS
  HK in POEM can shorten the procedural time, and achieve similar treatment success compared to conventional TT knife.
authors.affiliation: a 1 Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China.|b 2 Departmemt of Gastroenterology, Beijing Tsinghua Changgung Hospital Medical Center, Tsinghua University , Beijing, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Tang
authors.affiliation: a 1 Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.affiliation: a 1 Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Deng
authors.affiliation: a 1 Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China.|b 2 Departmemt of Gastroenterology, Beijing Tsinghua Changgung Hospital Medical Center, Tsinghua University , Beijing, China.
authors.forename: Jieqiong
authors.initials: J
authors.lastname: Zhou
authors.affiliation: b 2 Departmemt of Gastroenterology, Beijing Tsinghua Changgung Hospital Medical Center, Tsinghua University , Beijing, China.
authors.forename: Yutang
authors.initials: Y
authors.lastname: Ren
authors.affiliation: a 1 Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: a 1 Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Chen
authors.affiliation: a 1 Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China.|b 2 Departmemt of Gastroenterology, Beijing Tsinghua Changgung Hospital Medical Center, Tsinghua University , Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004931:Esophageal Achalasia / Q000601:surgery*; D016629:Esophagectomy / Q000295:instrumentation / Q000379:methods; D004945:Esophagoscopy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Hybrid knife; esophageal achalasia; peroral endoscopic myotomy; triangle tip knife