title: Bilateral synchronous low-grade adenosquamous carcinoma of the breast: A Case report with review of the current literature.
abstract: BACKGROUND
  Low-grade adenosquamous carcinoma (LGASC) is a rare, unique variant of metaplastic breast carcinoma, characterized by clinical indolence and low-grade cytomorphology. Being clinically asymptomatic with indefinite imaging characteristics, diagnosis is solely dependent on histopathology.
  
  
  METHODS
  A 68-year-old woman presented to the Breast Health Center with mammogram-detected left-sided retroareolar calcifications. She had a three-year history of non-progressive bilateral nipple inversion, and was otherwise asymptomatic. Left breast biopsy revealed atypical metaplastic squamous epithelial cells. Subsequently a wire-guided lumpectomy diagnosed a syringomatous adenoma of the nipple. A surveillance MRI identified a contralateral breast lesion, which on core biopsy showed an atypical adenosquamous lesion. Bilateral central mastectomies with bilateral sentinel node biopsies were undertaken. Histopathological review of both breast specimens confirmed the unique features of adenosquamous carcinoma identified by an infiltrative pattern of small rounded compressed angulated glands with squamous differentiation and low-grade cytomorphology. The tumors were triple negative [ER, PR, HER2]. The sentinel lymph nodes were negative.
  
  
  CONCLUSIONS
  Bilateral synchronous LGASC of the breasts is exceedingly uncommon and remains a diagnostic and therapeutic challenge. Despite being triple negative, due to its indolent behavior, recognition of this unusual primary breast malignancy is important as it has a more favorable prognosis. Yet, due to its rarity, there are no guidelines for best practice management regarding the role of adjuvant therapy.
authors.affiliation: Department of Plastic Surgery, University of Alberta, Canada.
authors.forename: J L
authors.initials: JL
authors.lastname: Senger
authors.affiliation: Department of Surgery, University of Saskatchewan, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Meiers
authors.affiliation: Department of Pathology & Laboratory Medicine, University of Saskatchewan, Canada. Electronic address: rani.kanthan@saskatoonhealthregion.ca.
authors.forename: R
authors.initials: R
authors.lastname: Kanthan
keywords: Low-grade adenosquamous carcinoma; Metaplastic breast cancer; Sclerosing lesions of the breast; Syringomatous adenoma of the nipple