title: Elucidating the mechanisms of transcription regulation during heart development by next-generation sequencing.
abstract: Dysregulation of transcription is associated with the pathogenesis of cardiovascular diseases, including congenital heart diseases and heart failure. However, it remains unclear how transcription factors regulate transcription in the heart and which genes are associated with cardiovascular diseases in humans. Development of genome-wide analyses using next-generation sequencers provides powerful methods to determine how these transcription factors and chromatin regulators control gene expressions and to identify causative genes in cardiovascular diseases. These technologies have revealed that transcription during heart development is elaborately regulated by multiple cardiac transcription factors. In this review, we discuss the recent progress toward understanding the molecular mechanisms of how transcriptional dysregulation leads to cardiovascular diseases.
authors.affiliation: Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nimura
authors.affiliation: Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Kaneda
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics*; D002843:Chromatin / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D024510:Muscle Development / Q000235:genetics; D009154:Mutation; D009206:Myocardium / Q000378:metabolism; D017422:Sequence Analysis, DNA; D017423:Sequence Analysis, RNA; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin