title: [Clinical evaluation of the consistency between two diagnostic criteria for diabetic peripheral neuropathy].
abstract: OBJECTIVE
  To evaluate the consistency between the clinical diagnostic criteria and the ascertained diagnostic criteria for diabetic peripheral neuropathy (DPN) in the Preventive and Treatment Guidelines of Diabetes in China (2013) and explore an economic, convenient, and accurate approach to DPN diagnosis.
  
  
  METHODS
  The patients with type 2 diabetes admitted in our department from April to June, 2014 were examined for nerve conduction velocity, 10 g nylon silk, vibration threshold value, sense of temperature and pain, and ankle reflex. The sensitivity, specificity, positive predictive value, negative predictive value, Youden index, and Kappa value were calculated to assess the diagnostic power of the two diagnostic criteria.
  
  
  RESULTS
  Of the 151 patients enrolled, 106 (70.2%) had a diagnosis of DPN consistent with the ascertained diagnostic criteria, as compared to 86 (56.95%) who were diagnosed according to the clinical diagnostic criteria; the latter patients accounted for 81.13% of former cases. The sensitivity, specificity, positive predictive value, negative predictive value, Youden index, and Kappa value of the clinical diagnostic criteria were 80.19%, 97.78%, 98.84%, 67.69%, 77.97%, and 0.69, respectively, which were highly consistent with those of the ascertained diagnostic criteria; the sensitivity to compression showed a poor consistency between the two diagnostic criteria. In the 5 screening tests, the combined test of temperature sensation, vibration perception, and ankle reflex showed the highest AUC value among their different combinations.
  
  
  CONCLUSIONS
  The clinical diagnostic criteria for DPN show good consistency with the ascertained diagnostic criteria, and for patients with clinical symptoms or with only one positive sign, combination of the two diagnostic criteria can achieve the maximum diagnostic power.
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.E-mail: wm896464@163.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Guo
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Liu
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Liu
authors.forename: Songyan
authors.initials: S
authors.lastname: Liu
authors.forename: Sen
authors.initials: S
authors.lastname: Wang
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Hao
authors.forename: Jingjing
authors.initials: J
authors.lastname: Huo
authors.forename: Yingna
authors.initials: Y
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Qi
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Shijia
authors.initials: S
authors.lastname: Yu
mesh_terms: D002681:China; D003924:Diabetes Mellitus, Type 2; D003929:Diabetic Neuropathies / Q000175:diagnosis*; D006801:Humans; D009460:Neurologic Examination / Q000379:methods*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity