title: A retrospective analysis of kidney function and risk factors by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in elderly Chinese patients.
abstract: Chronic kidney disease accounts for much of the increased mortality, especially in the elder population. The prevalence of this disease is expected to increase significantly as the society ages. Our aim was to evaluate the kidney function and risk factors of reduced renal function among elderly Chinese patients. This study retrospectively collected clinical data from a total of 1062 inpatients aged 65 years or over. Estimated glomerular filtration rate (eGFR) was calculated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Renal function and risk factors were also analyzed. For all 1062 subjects, the mean eGFR was 71.0 ± 24.8 mL/min/1.73 m(2), and the incidence rates of reduced renal function, proteinuria, hematuria and leukocyturia were 31.1%, 11.8%, 6.6% and 8.7%, respectively. The eGFR values were 83.4 ± 28.4, 72.2 ± 22.9, 67.8 ± 24.3 and 58.8 ± 29.1 mL/min/1.73 m(2) in the groups of 60-69, 70-79, 80-89 and ≥90 years age group (F = 15.101, p = 0.000), respectively; while the incidences of reduced renal function were 12.8%, 27.0%, 37.8% and 51.7% (χ(2) = 36.143, p = 0.000). Binary logistic regression analysis showed that hyperuricemia (OR = 4.62, p = 0.000), proteinuria (OR = 3.96, p = 0.000), urinary tumor (OR = 2.92, p = 0.015), anemia (OR = 2.45, p = 0.000), stroke (OR = 1.96, p = 0.000), hypertension (OR = 1.83, p = 0.006), renal cyst (OR = 1.64, p = 0.018), female (OR = 1.54, p = 0.015), coronary artery disease (OR = 1.53, p = 0.008) and age (OR = 1.05, p = 0.000) were the risk factors of reduced renal function. In conclusion, eGFR values decreased by age, while the incidence of reduced renal function, proteinuria, hematuria and leukocyturia increased with age. Treatment and control of comorbidities may slow the decline of renal function in elderly patients.
authors.affiliation: a Department of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute , Guangzhou , China .
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: a Department of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute , Guangzhou , China .
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.affiliation: a Department of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute , Guangzhou , China .
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wu
authors.affiliation: a Department of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute , Guangzhou , China .
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Fang
authors.affiliation: a Department of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute , Guangzhou , China .
authors.forename: Wenxue
authors.initials: W
authors.lastname: Hu
authors.affiliation: b Department of Cardiology , Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China .
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: c Ultrasonic Division , Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China , and.
authors.forename: Ruili
authors.initials: R
authors.lastname: Zhou
authors.affiliation: d Binjiang Street Community Health Service Center, Haizhu District , Guangzhou , China.
authors.forename: Xinge
authors.initials: X
authors.lastname: Lin
authors.affiliation: a Department of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute , Guangzhou , China .
authors.forename: Wenke
authors.initials: W
authors.lastname: Hao
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002681:China; D015897:Comorbidity; D003404:Creatinine / Q000032:analysis*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D011379:Prognosis; D011507:Proteinuria / Q000453:epidemiology; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology
chemical_list: D003404:Creatinine
keywords: Chronic kidney disease; elderly; glomerular filtration rate; risk factor