title: Preclinical testing of drug delivery systems to bone.
abstract: Bone defects do not heal in 5-10% of the fractures. In order to enhance bone regeneration, drug delivery systems are needed. They comprise a scaffold with or without inducing factors and/or cells. To test these drug delivery systems before application in patients, they finally need to be tested in animal models. The choice of animal model depends on the main research question; is a functional or mechanistic evaluation needed? Furthermore, which type of bone defects are investigated: load-bearing (i.e. orthopedic) or non-load-bearing (i.e. craniomaxillofacial)? This determines the type of model and in which type of animal. The experiments need to be set-up using the 3R principle and must be reported following the ARRIVE guidelines.
authors.affiliation: Experimental Trauma Surgery, Department of Trauma Surgery, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich, Germany. Electronic address: Martijn.vanGriensven@tum.de.
authors.forename: Martijn
authors.initials: M
authors.lastname: van Griensven
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D004164:Diphosphonates / Q000008:administration & dosage; D004195:Disease Models, Animal; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D059630:Mesenchymal Stem Cells; D054457:Tissue Scaffolds
chemical_list: D004164:Diphosphonates; D036341:Intercellular Signaling Peptides and Proteins
keywords: Animal model; Bone regeneration; Critical size defect; Large animals; Load-bearing; Non-union; Rat; Sheep