title: 2-Oxo promoted hydrophosphonylation & aerobic intramolecular nucleophilic displacement reaction.
abstract: Highly efficient catalyst free methods for the synthesis of α-hydroxy-β-oxophosphonates and α-oxoesters have been described. The existence of a 2-oxo group in α-oxoaldehydes is a key factor in promoting the reaction of the tervalent phosphite form towards 2-oxoaldehydes in the synthesis of α-hydroxy-β-oxophosphonates. The in situ activated α-C-H atom of α-hydroxy-β-oxophosphonates sustains aerobic intramolecular nucleophilic displacement in a curious way to produce α-oxoester.
authors.affiliation: Medicinal Chemistry Division, Indian Institute of Integrative Medicine (IIIM), (IIIM/1787/2015), Jammu, 180001, India. naqazi@iiim.ac.in.
authors.forename: Satyanarayana
authors.initials: S
authors.lastname: Battula
authors.forename: Narsaiah
authors.initials: N
authors.lastname: Battini
authors.forename: Deepika
authors.initials: D
authors.lastname: Singh
authors.forename: Qazi Naveed
authors.initials: QN
authors.lastname: Ahmed
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D017905:Phosphites / Q000737:chemistry; D010766:Phosphorylation
chemical_list: D000447:Aldehydes; D004952:Esters; D063065:Organophosphonates; D017905:Phosphites