title: Association of COX-2 -765G>C genetic polymorphism with coronary artery disease: a meta-analysis.
abstract: BACKGROUND
  Previous studies suggested the single nucleotide polymorphism (SNP) of COX-2 -765G>C (rs20417) is associated with coronary artery disease (CAD), but the results were conflicting. In order to derive a more precise estimation of the associations, we performed a meta-analysis of the relationship between rs20417 and CAD in all published studies.
  
  
  METHODS
  Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. Data were extracted using standardized methods. The association was assessed by odds ratio (OR) with 95% confidence intervals (CIs).The statistical tests were performed using Review Manager 5.3.3 and Stata 12.0 software.
  
  
  RESULTS
  We identified a total of 14 studies involving a total of 18227 subjects. The pooled odds ratio (OR) for the association between COX-2 -765G>C and CAD and its corresponding 95% confidence interval (95% CI) were evaluated by random or fixed effect model. A significant statistical association between COX-2 -765G>C and CAD was observed in an allelic model (P=0.02, OR=0.64, 95% CI: 0.43-0.94), dominant model (P=0.04, OR=0.74, 95% CI: 0.56-0.99), and recessive model (P=0.02, OR=0.46, 95% CI: 0.23-0.90).
  
  
  CONCLUSIONS
  This meta-analysis suggested that COX-2 -765G>C is a protective for CAD.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Zhen-Yan
authors.initials: ZY
authors.lastname: Fu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P. R. China.
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
keywords: PTGS2; coronary heart disease; meta-analysis; polymorphism