title: Evaluating the therapeutic efficacy, tolerability, and safety of an aqueous extract of Costus speciosus rhizome in acute pharyngitis and acute tonsillitis. A pilot study.
abstract: OBJECTIVE
  To determine the efficacy, tolerability, and safety of an aqueous extract of Costus speciosus (C. speciosus) rhizome in pediatric and adult patients suffering from acute pharyngitis and tonsillitis as an alternative to antibiotics use.
  
  
  METHODS
  This pilot cohort trial was conducted at King Abdulaziz University in Saudi Arabia between May and December 2014, among 15 patients with acute pharyngitis and tonsillitis who were administered nasal drops of aqueous extract of C. speciosus rhizome at a dose of 15-30 drops every 8 hours for 3 days. The primary outcome measure was the clinical improvement and remission rate within the first 5 days.
  
  
  RESULTS
  The administration of C. speciosus resulted in an improvement in acute symptoms in 60% of the patients treated within the first 24 hours, and remission rate of 93% by day 5, without any recorded adverse effects.
  
  
  CONCLUSIONS
  This study revealed a significant efficacy of the aqueous extract of C. speciosus rhizome in acute pharyngitis and tonsillitis.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail. zabakhsh@kau.edu.sa.
authors.forename: Zainab A
authors.initials: ZA
authors.lastname: Bakhsh
authors.forename: Talal A
authors.initials: TA
authors.lastname: Al-Khatib
authors.forename: Saad M
authors.initials: SM
authors.lastname: Al-Muhayawi
authors.forename: Sufian M
authors.initials: SM
authors.lastname: ElAssouli
authors.forename: Iman A
authors.initials: IA
authors.lastname: Elfiky
authors.forename: Samiha A
authors.initials: SA
authors.lastname: Mourad
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D029770:Costus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010612:Pharyngitis / Q000188:drug therapy*; D008517:Phytotherapy / Q000009:adverse effects; D010865:Pilot Projects; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D027343:Rhizome; D014069:Tonsillitis / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010936:Plant Extracts