title: Spontaneous Activity Associated with Delusions of Schizophrenia in the Left Medial Superior Frontal Gyrus: A Resting-State fMRI Study.
abstract: Delusions of schizophrenia have been found to be associated with alterations of some brain regions in structure and task-induced activation. However, the relationship between spontaneously occurring symptoms and spontaneous brain activity remains unclear. In the current study, 14 schizophrenic patients with delusions and 14 healthy controls underwent a resting-state functional magnetic resonance imaging (RS-fMRI) scan. Patients with delusions of schizophrenia patients were rated with Positive and Negative Syndrome Scale (PANSS) and Characteristics of Delusional Rating Scale (CDRS). Regional homogeneity (ReHo) was calculated to measure the local synchronization of the spontaneous activity in a voxel-wise way. A two-sample t-test showed that ReHo of the right anterior cingulate gyrus and left medial superior frontal gyrus were higher in patients, and ReHo of the left superior occipital gyrus was lower, compared to healthy controls. Further, among patients, correlation analysis showed a significant difference between delusion scores of CRDS and ReHo of brain regions. ReHo of the left medial superior frontal gyrus was negatively correlated with patients' CDRS scores but not with delusional PANSS scores. These results suggested that altered local synchronization of spontaneous brain activity may be related to the pathophysiology of delusion in schizophrenia.
authors.affiliation: Department of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Gao
authors.affiliation: Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, PR China; Mental Health Center, School of Medicine, Zhe Jiang University, Hangzhou, Zhejiang, PR China.
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Liu
authors.affiliation: Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, PR China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Hangzhou First People's Hospital, Hangzhou, Zhejiang, PR China.
authors.forename: Heshan
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
authors.forename: Jinyu
authors.initials: J
authors.lastname: Yang
authors.affiliation: Alpert Medical School of Brown University, Richmond St., Providence, RI, United States of America.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Cohen
authors.affiliation: Department of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China; Mental Health Education and Counseling Center, Zhejiang University, Hangzhou, Zhejiang, PR China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, PR China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zang
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003702:Delusions / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000503:physiopathology*; D055815:Young Adult