title: [Locally Advanced Gastric Cancer Treated with Curative Gastrectomy and Showing Pathological Complete Response after Chemotherapy with S-1].
abstract: A 77-year-old man presented with epigastralgia. Gastrointestinal endoscopic examination showed advanced gastric cancer, type 3, in the distal antrum. The patient refused surgery and preferred chemotherapy. The regimen consisted of 80 mg/body/day of S-1, continuously administered from day 1-14, followed by discontinuation for 2 weeks. After 2 courses, the patient experienced fatigue and recurrent vomiting. Laboratory studies revealed severe anemia; the hemoglobin level was 5.5 g/dL. An upper gastrointestinal endoscopy revealed pyloric stenosis and significant tumor reduction. Therefore, distal gastrectomy was performed. Histological examination did not reveal any viable cancer cells in the stomach and lymph nodes. Thus, a Grade 3 postchemotherapeutic effect was revealed.
authors.affiliation: Dept. of Gastroenterology, Saiseikai Shiga Prefectural Hospital.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Shigematsu
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Murai
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Masanobu
authors.initials: M
authors.lastname: Katayama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okajima
authors.forename: Motoo
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masamichi
authors.initials: M
authors.lastname: Baba
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020360:Neoadjuvant Therapy; D010094:Oxonic Acid / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid