title: Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats.
abstract: Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread musculoskeletal pain and depressive-like symptoms, but the methodology used to measure such symptoms has been criticized. Evidence relates the high prevalence of pain and depression in fibromyalgia to common pathogenic pathways, most probably focused on the monoaminergic system. The present study aims at a validation of the reserpine model of fibromyalgia. For this purpose, rats undergoing this model have been tested for depressive-like symptoms with a Novelty-Suppressed Feeding Test adaptation. Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. They also took more time to eat from the central food than control rats. These NSFT findings suggest the presence of depressive-like disorders in this animal model of fibromyalgia.
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
authors.forename: Arantxa
authors.initials: A
authors.lastname: Blasco-Serra
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Escrihuela-Vidal
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
authors.forename: Eva M
authors.initials: EM
authors.lastname: González-Soler
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Martínez-Expósito
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Blasco-Ausina
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martínez-Bellver
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Cervera-Ferri
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
authors.forename: Vicent
authors.initials: V
authors.lastname: Teruel-Martí
authors.affiliation: Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain. Electronic address: valverde@uv.es.
authors.forename: Alfonso A
authors.initials: AA
authors.lastname: Valverde-Navarro
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000633:toxicity*; D000818:Animals; D003863:Depression / Q000209:etiology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005356:Fibromyalgia / Q000139:chemically induced* / Q000150:complications*; D019417:Hindlimb Suspension; D007266:Inhibition, Psychological; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000633:toxicity*; D013997:Time Factors
chemical_list: D018759:Adrenergic Uptake Inhibitors; D012110:Reserpine
keywords: Animal pain model; Depression; Fibromyalgia; Novelty-Suppressed Feeding Test; Reserpine