title: MYTHS AND CONTROVERSIES IN HYPOGONADISM TREATMENT OF AGING MALES.
abstract: Low T is an independent risk factor for metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) development; patients with these clinical conditions should be screened for hypogonadism. Testosterone replacement therapy (TRT) ameliorates libido, improves bone mass, improves insulin resistance, reduces fat mass and increases lean body mass with no change in body weight. There are no evidences that testosterone therapy increases the risk of prostate cancer but it is certain that testosterone stimulates growth of metastatic prostate cancer. TRT has an antiarrhythmic and a vasodilator effect, independent of the nitric oxide effect. Patients with heart failure have low levels of testosterone, and TRT improves exercise capacity. Men with low testosterone have risk for premature death. Cardiovascular adverse effects of testosterone therapy are under discussion. We need large prospective placebo-controlled randomized trials to determine definitively the cardiovascular risks of TRT.
authors.forename: Maria-Christina
authors.initials: MC
authors.lastname: Ungureanu
authors.forename: Irina-Iuliana
authors.initials: II
authors.lastname: Costache
authors.forename: Cristina
authors.initials: C
authors.lastname: Preda
authors.forename: Voichiţa
authors.initials: V
authors.lastname: Mogoş
authors.forename: Carmen
authors.initials: C
authors.lastname: Vulpoi
authors.forename: Letiţia
authors.initials: L
authors.lastname: Leuştean
mesh_terms: D000368:Aged; D000375:Aging; D000728:Androgens / Q000008:administration & dosage / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications; D011788:Quality of Life; D015203:Reproducibility of Results; D012307:Risk Factors; D013739:Testosterone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D000728:Androgens; D000889:Anti-Arrhythmia Agents; D013739:Testosterone