title: Effect of Tetracycline Hydrochloride and Spiramycin Sub Gingival Irrigation with Pulsated Jet Irrigator in Chronic Periodontitis Patients: A Clinical Study.
abstract: BACKGROUND
  The present study is designed to evaluate the clinical effects of pulsated subgingival irrigation with tetracycline and spiramycin.
  
  
  METHODS
  Ten patient diagnosed chronic periodontitis were included in the present study. Each patient is assigned to be irrigated with saline (placebo) (Group A), tetracycline HCl at 0.5% concentration (Group B), and 0.5% spiramycin (Group C). Scaling and root planing (SC/RP) was recorded as Group D. Plaque index, gingival index, gingival bleeding index, probing pocket depth were assessed on pre-irrigation (day 0), and at days 7, 14, 21, 28, and 35 day.
  
  
  RESULTS
  The results showed that subgingival irrigation with 0.5% tetracycline and spiramycin produced a significant reduction in clinical parameters compared to the control, while SC/RP was showed better improvement.
  
  
  CONCLUSIONS
  The result of this study suggested that subgingival irrigation of tetracycline and spiramycin play a beneficial role in the management of chronic periodontitis patients.
authors.affiliation: Professor & Head, Department of Periodontia, SRM Kattankulathur Dental College & Hospital, Kattankulathur, Tamil Nadu, India.
authors.forename: P L
authors.initials: PL
authors.lastname: Ravishankar
authors.affiliation: Reader, Department of Periodontia, Sri Sai Dental College, Srikakulam, Andhra Pradesh, India.
authors.forename: K
authors.initials: K
authors.lastname: Venugopal
authors.affiliation: Professor and Head, Department of Periodontia, New Horizon Dental College, Bilaspur, Chhattisgarh, India.
authors.forename: Purnima
authors.initials: P
authors.lastname: Nadkerny
keywords: Spiramycin; subgingival irrigation; tetracycline hydrochloride