title: Pharmacometrics: Focus on the Patient.
abstract: Pharmacometrics, whether using simple or complex models, has contributed to rational and efficient drug development,(1-3) with the main focus on early drug development.(4) This article describes why opportunities more directly focused on the patient abound in late stage development, illustrating the concept with three innovative examples which focus on benefits to patients, enabling drugs that are truly efficacious to reach the market faster in diseases with high unmet medical needs, while maintaining adequate safety.
authors.affiliation: Clinical Pharmacology Modeling and Simulation, GSK RTP, North Carolina, USA.
authors.forename: T Pene
authors.initials: TP
authors.lastname: Dumitrescu
authors.affiliation: Clinical Pharmacology Modeling and Simulation, GSK Upper Merion, Pennsylvania, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Fossler
authors.affiliation: Clinical Pharmacology Modeling and Simulation, GSK RTP, North Carolina, USA.
authors.forename: V D
authors.initials: VD
authors.lastname: Schmith