title: Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide.
abstract: Novel metal(II) complexes derived from 2-hydroxy-N'-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA and TGA), IR, UV-VIS, (1)H-NMR, ESR and mass spectroscopy, magnetic susceptibilities, and conductivities measurements. The complexes adopt distorted octahedral geometry. The ESR spectra of the solid copper(II) complexes are characteristic to d(9) configuration and have an axial symmetry type of a d(x (2)-y (2)) ground state. The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment. The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).
authors.affiliation: Department of Chemistry, Faculty of Science, Menoufia University, P.O. Box 5744, Shibin Al Kawm, Egypt.
authors.forename: Abdou Saad
authors.initials: AS
authors.lastname: El-Tabl
authors.affiliation: Department of Pathology, Faculty of Medicine, Menoufia University, P.O. Box 5744, Shibin Al Kawm, Egypt.
authors.forename: Moshira
authors.initials: M
authors.lastname: Mohamed Abd El-Waheed
authors.affiliation: Inorganic Chemistry Department, National Research Centre, Dokki, Cairo 12311, Egypt.
authors.forename: Mohammed Ahmed
authors.initials: MA
authors.lastname: Wahba
authors.affiliation: Department of Chemistry, Faculty of Science, Menoufia University, P.O. Box 5744, Shibin Al Kawm, Egypt.
authors.forename: Nahla
authors.initials: N
authors.lastname: Abd El-Halim Abou El-Fadl