title: Blood and Urinary Abnormalities Induced During and After 24-Hour Continuous Running: A Case Report.
abstract: In this reported clinical case, a healthy and well-trained male subject [aged 37 years, maximal oxygen uptake (V[Combining Dot Above]O2max) 64 mL·kg·min] ran for 23 hours and 35 minutes covering 160 km (6.7 km/h average running speed). The analysis of hematological and biochemical parameters 3 days before the event, just after termination of exercise, and after 24 and 48 hours of recovery revealed important changes on muscle and liver function, and hemolysis. The analysis of urine sediments showed an increment of red and white blood cells filtrations, compatible with transient nephritis. After 48 hours, most of these alterations were recovered. Physicians and health professionals who monitor such athletic events should be aware that these athletes could exhibit transient symptoms compatible with severe pathologies and diseases, although the genesis of these blood and urinary abnormalities are attributable to transient physiological adaptations rather to pathological status.
authors.affiliation: *Hospital Universitario 12 de Octubre, Research Institute (i+12), Madrid, Spain; †Research Institute "Dr. ViñaGiner," Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain; ‡School of Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain; §GENUD "Growth, Exercise, NUtrition and Development" Research Group, Universidad de Zaragoza, Zaragoza, Spain; ¶Faculty of Health and Sport Science, University of Zaragoza, Huesca, Spain; and ‖European University of Madrid, Madrid, Spain.
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.forename: Rafael
authors.initials: R
authors.lastname: Alis
authors.forename: Germán
authors.initials: G
authors.lastname: Rodríguez-Vicente
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
authors.forename: José A
authors.initials: JA
authors.lastname: Casajús
authors.forename: Nuria
authors.initials: N
authors.lastname: Garatachea
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D006461:Hemolysis; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009393:Nephritis / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000652:urine; D012420:Running / Q000502:physiology*
chemical_list: D015415:Biomarkers