title: New advances in genitourinary cancer: evidence gathered in 2014.
abstract: This review provides updated information published in 2014 regarding advances and major achievements in genitourinary cancer. Sections include the best in prostate cancer, renal cancer, bladder cancer, and germ cell tumors. In the field of prostate cancer, data related to treatment approach of hormone-sensitive disease, castrate-resistant prostate cancer, mechanisms of resistance, new drugs, and molecular research are presented. In relation to renal cancer, relevant aspects in the treatment of advanced renal cell carcinoma, immunotherapy, and molecular research, including angiogenesis and von Hippel-Lindau gene, molecular biology of non-clear cell histologies, and epigenetics of clear renal cell cancer are described. New strategies in the management of muscle-invasive localized bladder cancer and metastatic disease are reported as well as salient findings of biomolecular research in urothelial cancer. Some approaches intended to improve outcomes in poor prognosis patients with metastatic germ cell cancer are also reported. Results of clinical trials in these areas are discussed.
authors.affiliation: Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Suárez
authors.affiliation: Medical Oncology Department, Hospital Clínico Universitario San Carlos, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Puente
authors.affiliation: Medical Oncology Department, Hospital Universitari Parc Taulí, Sabadell, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Gallardo
authors.affiliation: Medical Oncology Department, Instituto Maimónides de Investigación Biomédica (IMIBIC), Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Méndez-Vidal
authors.affiliation: Medical Oncology Department, Fundación Instituto Valenciano de Oncología, Valencia, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Climent
authors.affiliation: Medical Oncology Department, Hospital Clínico, Santiago de Compostela, A Coruña, Spain.
authors.forename: L
authors.initials: L
authors.lastname: León
authors.affiliation: Prostate Cancer Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.|CNIO-IBIMA Genitourinary Cancer Research Unit, Hospitales Universitarios Virgen de la Victoria & Regional de Málaga, Madrid, Spain.|Centro Integral Oncológico Clara Campal, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Olmos
authors.affiliation: Institut Català d'Oncologia L'Hospitalet, Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: García del Muro
authors.affiliation: Medical Oncology and Hematology Department, Hospital G. U. Morales Meseguer, Murcia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: González-Billalabeitia
authors.affiliation: Medical Oncology Department, GI, Endocrine and Translational Research Unit, Early Drug Development Unit-IRYCIS, Ramon y Cajal University Hospital, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Grande
authors.affiliation: Bladder Cancer Center, Dana-Farber Cancer Institute, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bellmunt
authors.affiliation: Medical Oncology Department, Hospital Clinic, Barcelona, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Mellado
authors.affiliation: Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Maroto
authors.affiliation: Medical Oncology Department, Hospital Universitario Son Espases, Carretera de Valldemosa 79, 07010, Palma de Mallorca, Spain. aranzazu.gonzalezdelalba@ssib.es.
authors.forename: A
authors.initials: A
authors.lastname: González del Alba
mesh_terms: D006801:Humans; D014565:Urogenital Neoplasms / Q000628:therapy*
keywords: Bladder cancer; Genitourinary cancer; Germ cell tumors; Molecular research; Prostate cancer; Renal cancer