title: Stereoselective Synthesis of 3-Carboxy-4,5-dihydropyrroles via an Intramolecular Iminium Ion Cyclization Reaction.
abstract: An efficient and practical method has been developed for the synthesis of trans-4,5-disubstituted 3-carboxy-4,5-dihydropyrroles via an intramolecular iminium ion cyclization reaction of readily accessible Baylis-Hillman derivatives and aldehydes in moderate to high yield. These new dihydropyrroles could be easily converted to pyrroles or pyrrolidines.
authors.affiliation: The Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.
authors.forename: Jinbao
authors.initials: J
authors.lastname: Xiang
authors.affiliation: The Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Xie
authors.affiliation: The Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Li
authors.affiliation: The Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Dang
authors.affiliation: The Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Bai