title: Lower LINE-1 methylation in first-episode schizophrenia patients with the history of childhood trauma.
abstract: OBJECTIVE
  We investigated methylation of DNA repetitive sequences (LINE-1 and BAGE) in peripheral blood leukocytes from first-episode schizophrenia (FES) patients and healthy controls (HCs) with respect to childhood adversities.
  
  
  METHODS
  Patients were divided into two subgroups based on the history of childhood trauma - FES(+) and FES(-) subjects. The majority of HCs had a negative history of childhood trauma - HCs(-) subjects.
  
  
  RESULTS
  FES(+) patients had significantly lower LINE-1 methylation in comparison with FES(-) patients or HC(-) subjects. Emotional abuse and total trauma score predicted lower LINE-1 methylation in FES patients, while general trauma score was associated with lower BAGE methylation in HCs.
  
  
  CONCLUSIONS
  Childhood adversities might be associated with global DNA hypomethylation in adult FES patients.
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.|Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.
authors.forename: Błażej
authors.initials: B
authors.lastname: Misiak
authors.affiliation: Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Szmida
authors.affiliation: Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Karpiński
authors.affiliation: Department of Professional Training in Clinical Chemistry, Wroclaw Medical University, 211A Borowska Street, 50-566 Wroclaw, Poland.
authors.forename: Olga
authors.initials: O
authors.lastname: Loska
authors.affiliation: Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Sąsiadek
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Frydecka
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000235:genetics; D015415:Biomarkers; D016022:Case-Control Studies; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D020084:Long Interspersed Nucleotide Elements; D008297:Male; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000209:etiology*; D014947:Wounds and Injuries / Q000150:complications; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; C092706:BAGE protein, human; D015415:Biomarkers
keywords: BAGE; DNA methylation; LINE-1; childhood trauma; first-episode schizophrenia; repetitive DNA sequences; stress