title: Data from human salivary proteome - A resource of potential biomarkers for oral cancer.
abstract: Salivary proteins are an important source for developing marker-based assays for oral cancers. To get an insight into the proteins present in human saliva, we applied multiple strategies involving affinity-based depletion of abundant proteins, fractionation of the resulting proteins or their tryptic peptides followed by LC-MS/MS analysis, using high resolution mass spectrometry. By integrating the protein identifications observed by us with those from similar workflows employed in earlier investigations, we compiled an updated salivary proteome. We have mapped the salivary proteome to the published data on differentially expressed proteins from oral cancer tissues and also for their secretory features using prediction tools, SignalP 4.1, TMHMM 2c and Exocarta. Proteotypic peptides for the subset of proteins implicated in oral cancer and mapped to any two of the prediction tools for secretory potential have been listed. The data here are related to the research article "Human saliva proteome - a resource of potential biomarkers for oral cancer" in the Journal of Proteomics [1].
authors.affiliation: Head and Neck Oncology, Mazumdar Shaw Medical Center, Narayana Health, Bangalore 560099, India ; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Sivadasan
authors.affiliation: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar Gupta
authors.affiliation: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
authors.forename: Gajanan J
authors.initials: GJ
authors.lastname: Sathe
authors.affiliation: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Balakrishnan
authors.affiliation: Head and Neck Oncology, Mazumdar Shaw Medical Center, Narayana Health, Bangalore 560099, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Palit
authors.affiliation: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
authors.forename: Harsha
authors.initials: H
authors.lastname: Gowda
authors.affiliation: Head and Neck Oncology, Mazumdar Shaw Medical Center, Narayana Health, Bangalore 560099, India ; Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, Narayana Health, Bangalore 560099, India.
authors.forename: Amritha
authors.initials: A
authors.lastname: Suresh
authors.affiliation: Head and Neck Oncology, Mazumdar Shaw Medical Center, Narayana Health, Bangalore 560099, India ; Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, Narayana Health, Bangalore 560099, India.
authors.forename: Moni
authors.initials: M
authors.lastname: Abraham Kuriakose
authors.affiliation: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India ; Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, Narayana Health, Bangalore 560099, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Sirdeshmukh