title: Two new phenolic compounds from the leaves of Alnus sibirica Fisch. ex Turcz.
abstract: Two new phenolic compounds, 4-O-glucopyranosyl-5-O-caffeoylshikimic acid (1) and 2,3-digalloyl oregonin (2), were isolated along with eight known phenolic compounds (3-10) from an 80% acetone extract of Alnus sibirica leaves. The chemical structures of these compounds were elucidated using 1D/2D nuclear magnetic resonance and high resolution-MS. The anti-oxidative activities of these compounds were determined by assaying their 1,1-diphenyl-2-picrylhydrazyl radical and nitroblue tetrazolium superoxide anion scavenging activity. All of the isolated phenolic compounds (1-10) exhibited potent anti-oxidative activities. In particular, 2 and 4, which are diarylheptanoids, and 10 which is ellagitannin exhibited excellent anti-oxidative activities with almost the same potency as that of the positive controls L-ascorbic acid and allopurinol.
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Manh Heun
authors.initials: MH
authors.lastname: Kim
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Kwan Hee
authors.initials: KH
authors.lastname: Park
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: So Ra
authors.initials: SR
authors.lastname: Kim
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Kwang Jun
authors.initials: KJ
authors.lastname: Park
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Myeong Hwan
authors.initials: MH
authors.lastname: Oh
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Jun Hyeok
authors.initials: JH
authors.lastname: Heo
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Ki Hoon
authors.initials: KH
authors.lastname: Yoon
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Kyu Hyung
authors.initials: KH
authors.lastname: Yoon
authors.affiliation: a Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University , Seoul 156-756 , Republic of Korea.
authors.forename: Min Won
authors.initials: MW
authors.lastname: Lee
mesh_terms: D029661:Alnus / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D036381:Diarylheptanoids / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology; D047348:Hydrolyzable Tannins / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D012765:Shikimic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013481:Superoxides / Q000737:chemistry
chemical_list: C000609512:2,3-digalloyl oregonin; C000609511:4-O-glucopyranosyl-5-O-caffeoylshikimic acid; D000975:Antioxidants; D001713:Biphenyl Compounds; D036381:Diarylheptanoids; D016166:Free Radical Scavengers; D005960:Glucosides; D047348:Hydrolyzable Tannins; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; C013515:ellagitannin; D013481:Superoxides; D012765:Shikimic Acid; D005707:Gallic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid
keywords: Alnus sibirica; anti-oxidant activity; caffeoylshikimic acid; galloyl-diarylheptanoid