title: Growth Hormone 1 T1663A Polymorphism, Recreational Physical Activity and BMI, and Breast Cancer Risk in Chinese Women.
abstract: To evaluate the relationship between the growth hormone 1 (GH1) T1663A polymorphism, recreational physical activity and body mass index (BMI) with reference to breast cancer, we conducted a case-control study with 669 cases of breast cancer and 682 population-based controls in Jiangsu Province, China. A structured questionnaire was used to elicit detailed information. All subjects completed an in-person interview. GH1 genotypes were identified using PCR-RFLP methods. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of GH1 genotypes was not significantly different between controls and cases (χ2=2.576, P=0.276). Results of stratified analysis by the participation status of the recreational physical activity showed that the persons with GH1 A allele were at a decreased risk of breast cancer (adjusted-OR=0.66; 95% CI, 0.50-0.87) only among inactive individuals. Stratified analysis by BMI showed that the genotype A/A was associated with a decreased risk of breast cancer only among individuals of the BMI<25 (adjusted-OR=0.80; 95% CI, 0.66-0.98). The findings of this study suggest that recreational physical activity and BMI may modify any association between the GH1 T1663A polymorphism and breast cancer risk.
authors.affiliation: Division of Epidemiology, Jiangsu Province Institute of Cancer Research, Nanjing, Jiangsu Province, China E-mail : gaocm888@126.com.
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Gao
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Ding
authors.forename: Jian-Shong
authors.initials: JS
authors.lastname: Wu
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Cao
authors.forename: Su-Ping
authors.initials: SP
authors.lastname: Li
authors.forename: Yan-Ting
authors.initials: YT
authors.lastname: Liu
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Tang
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China; D015444:Exercise / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D019382:Human Growth Hormone / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D019382:Human Growth Hormone