title: Epithelial Tumors of the Ovary in Children and Teenagers: A Prospective Study from the Italian TREP Project.
abstract: OBJECTIVE
  To report the clinical findings and treatment results of a series of patients with epithelial tumors of the ovary, registered and treated prospectively in a multi-institutional Italian network (TREP project) on rare tumors in children and adolescent between 2000 and 2014.
  
  
  METHODS
  Data on 16 patients, aged 22 to 206 months, from 7 centers were reviewed. All patients were grouped on the basis of the results of the first surgical approach, according to the Children Oncology Group staging system.
  
  
  RESULTS
  The most frequent symptom was abdominal pain; 3 patients were hospitalized for acute pain after ovarian torsion. Initial surgical treatment was complete in 15 of 16, and a biopsy was performed in 1 of 16. The histology examination revealed 8 benign tumors (7 mucinous cystadenomas and 1 serous cystadenoma) and 8 borderline tumors (2 serous and 6 mucinous). Fifteen of 16 patients maintained the complete remission after surgical treatment alone; 1 affected by Proteus syndrome died consequent to the progression of a synchronous Wilms tumor, after a delayed incomplete surgery.
  
  
  CONCLUSIONS
  Our analysis documented the rarity of these tumors in children and adolescents. No malignant histologies were found. Surgery alone was effective to cure the majority of patients. Considering the rarity of malignant entities, ovary-sparing surgery may be planned when an epithelial tumor is suspected on the basis of the preoperative work-up and intraoperative findings.
authors.affiliation: Pediatric Surgery, Department of Women's and Children's Health, University-Hospital of Padua, Padua, Italy. Electronic address: cvirgone@gmail.com.
authors.forename: Calogero
authors.initials: C
authors.lastname: Virgone
authors.affiliation: Pathology Unit, Department of Medical and Diagnostic Sciences and Special Therapies, University of Padua, Padua, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Alaggio
authors.affiliation: Pediatric Surgery, Department of Women's and Children's Health, University-Hospital of Padua, Padua, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Dall'Igna
authors.affiliation: Pediatric Surgery, Giannina Gaslini Children's Hospital, Genoa, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Buffa
authors.affiliation: Pediatric Surgery, Children's Hospital, Brescia, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Tonegatti
authors.affiliation: Hematology Oncology, IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferrari
authors.affiliation: Hematology Oncology, Department of Women's and Children's Health, University-Hospital of Padua, Padua, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Bisogno
authors.affiliation: Pediatric Surgery, Department of Women's and Children's Health, University-Hospital of Padua, Padua, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cecchetto
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007223:Infant; D007558:Italy; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D011446:Prospective Studies
keywords: Borderline ovarian tumors; Epithelial ovarian tumors; Mucinous cystadenoma; Pediatric ovarian tumors; Serous cystadenoma