title: Single-trial dynamics of motor cortex and their applications to brain-machine interfaces.
abstract: Increasing evidence suggests that neural population responses have their own internal drive, or dynamics, that describe how the neural population evolves through time. An important prediction of neural dynamical models is that previously observed neural activity is informative of noisy yet-to-be-observed activity on single-trials, and may thus have a denoising effect. To investigate this prediction, we built and characterized dynamical models of single-trial motor cortical activity. We find these models capture salient dynamical features of the neural population and are informative of future neural activity on single trials. To assess how neural dynamics may beneficially denoise single-trial neural activity, we incorporate neural dynamics into a brain-machine interface (BMI). In online experiments, we find that a neural dynamical BMI achieves substantially higher performance than its non-dynamical counterpart. These results provide evidence that neural dynamics beneficially inform the temporal evolution of neural activity on single trials and may directly impact the performance of BMIs.
authors.affiliation: Electrical Engineering Department, Stanford University, Stanford, California 94305, USA.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Kao
authors.affiliation: 1] Bioengineering Department, Stanford University, Stanford, California 94305, USA [2] School of Medicine, Stanford University, Stanford, California 94305, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Nuyujukian
authors.affiliation: 1] Electrical Engineering Department, Stanford University, Stanford, California 94305, USA [2] Palo Alto Medical Foundation, Palo Alto, California 94301, USA.
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Ryu
authors.affiliation: Department of Neuroscience, Columbia University, New York, New York 10032, USA.
authors.forename: Mark M
authors.initials: MM
authors.lastname: Churchland
authors.affiliation: Department of Statistics, Columbia University, New York, New York 10027, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Cunningham
authors.affiliation: 1] Electrical Engineering Department, Stanford University, Stanford, California 94305, USA [2] Bioengineering Department, Stanford University, Stanford, California 94305, USA [3] Neurosciences Program, Stanford University, Stanford, California, USA [4] Neurobiology Department, Stanford University, Stanford, California 94305, USA [5] Bio-X Program, Stanford University, Stanford, California 94305, USA [6] Stanford Neurosciences Institute, Stanford University, Stanford, California 94305, USA.
authors.forename: Krishna V
authors.initials: KV
authors.lastname: Shenoy
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D062207:Brain-Computer Interfaces; D008253:Macaca mulatta; D008297:Male; D008959:Models, Neurological; D009044:Motor Cortex / Q000502:physiology*