title: First report of neonatal bacteremia caused by "Haemophilus quentini" diagnosed by 16S rRNA gene sequencing, Italy.
abstract: We report the first case of neonatal bacteremia caused by a "Haemophilus quentini" isolate in Italy. The isolate was differentiated from H. influenzae by 16S rRNA sequencing and was characterized by comparison with the wild-type "H. quentini" CCUG 36167. Both isolates carried substitutions in penicillin-binding protein 3 but were susceptible to aminopenicillins.
authors.affiliation: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Giufrè
authors.affiliation: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Cardines
authors.affiliation: Laboratory of Clinical Chemistry and Microbiology, Nuovo Ospedale di Prato "S. Stefano", Prato, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Degl'Innocenti
authors.affiliation: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy. Electronic address: marina.cerquetti@iss.it.
authors.forename: Marina
authors.initials: M
authors.lastname: Cerquetti
mesh_terms: D019943:Amino Acid Substitution; D000667:Ampicillin / Q000494:pharmacology; D016470:Bacteremia / Q000175:diagnosis* / Q000382:microbiology*; D001426:Bacterial Proteins / Q000235:genetics; D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D005260:Female; D020459:Genes, rRNA; D006190:Haemophilus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006192:Haemophilus Infections / Q000175:diagnosis* / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D046915:Penicillin-Binding Proteins / Q000235:genetics; D010802:Phylogeny; D011247:Pregnancy; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D046915:Penicillin-Binding Proteins; D012336:RNA, Ribosomal, 16S; D000667:Ampicillin
keywords: 16S rRNA sequencing; Haemophilus; Invasive disease; Neonatal infection; PBP3