title: Finding small molecules for the 'next Ebola'.
abstract: The current Ebola virus epidemic may provide some suggestions of how we can better prepare for the next pathogen outbreak. We propose several cost effective steps that could be taken that would impact the discovery and use of small molecule therapeutics including: 1. text mine the literature, 2. patent assignees and/or inventors should openly declare their relevant filings, 3. reagents and assays could be commoditized, 4. using manual curation to enhance database links, 5. engage database and curation teams, 6. consider open science approaches, 7. adapt the "box" model for shareable reference compounds, and 8. involve the physician's perspective.
authors.affiliation: Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay-Varina, NC, 27526, USA ; Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA, 94010, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Ekins
authors.affiliation: IUPHAR/BPS Guide to PHARMACOLOGY, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, Edinburgh, EH8 9XD, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Southan
authors.affiliation: Center for Infectious Diseases and Emergency Readiness, University of California at Berkeley, 1918 University Ave, Berkeley, CA, 94704, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Coffee
keywords: box model; databases; ebola; open science; outbreak; patents; text mining