title: Chemical Detoxification of Organomercurials.
abstract: Organomercurials including methylmercury are ubiquitous environmental pollutants and highly toxic to humans. Now it could be shown that N-methylimidazole based thiones/selones having an N-CH2CH2OH substituent are remarkably effective in detoxifying various organomercurials to produce less toxic HgE (E=S, Se) nanoparticles. Compounds lacking the N-CH2CH2OH substituent failed to produce HgE nanoparticles upon treatment with organomercurials, suggesting that this moiety plays a crucial role in the detoxification by facilitating the desulfurization and deselenization processes. This novel way of detoxifying organomercurials may lead to the discovery of new compounds to treat patients suffering from methylmercury poisoning.
authors.affiliation: Department of Chemistry, School of Natural Sciences, Shiv Nadar University, NH91, Dadri, Gautam Buddha Nagar, UP 201314 (India).
authors.forename: Mainak
authors.initials: M
authors.lastname: Banerjee
authors.affiliation: Department of Chemistry, School of Natural Sciences, Shiv Nadar University, NH91, Dadri, Gautam Buddha Nagar, UP 201314 (India).
authors.forename: Ramesh
authors.initials: R
authors.lastname: Karri
authors.affiliation: Discipline of Chemistry and Center for Material Science & Engineering, Indian Institute of Technology (IIT) Indore (India).
authors.forename: Kuber Singh
authors.initials: KS
authors.lastname: Rawat
authors.affiliation: Department of Chemistry, School of Natural Sciences, Shiv Nadar University, NH91, Dadri, Gautam Buddha Nagar, UP 201314 (India).
authors.forename: Karthick
authors.initials: K
authors.lastname: Muthuvel
authors.affiliation: Discipline of Chemistry and Center for Material Science & Engineering, Indian Institute of Technology (IIT) Indore (India).
authors.forename: Biswarup
authors.initials: B
authors.lastname: Pathak
authors.affiliation: Department of Chemistry, School of Natural Sciences, Shiv Nadar University, NH91, Dadri, Gautam Buddha Nagar, UP 201314 (India). gouriprasanna.roy@snu.edu.in.
authors.forename: Gouriprasanna
authors.initials: G
authors.lastname: Roy
mesh_terms: D004785:Environmental Pollutants / Q000737:chemistry* / Q000378:metabolism; D006878:Hydroxides / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D008767:Methylmercury Compounds / Q000737:chemistry* / Q000378:metabolism; D017680:Potassium Compounds / Q000737:chemistry; D012643:Selenium / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D004785:Environmental Pollutants; D006878:Hydroxides; D008767:Methylmercury Compounds; D017680:Potassium Compounds; D013438:Sulfhydryl Compounds; D012643:Selenium; C029943:potassium hydroxide
keywords: detoxification; mercury; organomercurials; selones; thiones