title: Elevated Human Endothelial Cell-Specific Molecule-1 Level and Its Association With Coronary Artery Disease in Patients With Hypertension.
abstract: BACKGROUND
  Endothelial dysfunction plays an important role in the pathophysiology of coronary artery disease (CAD). Previous studies suggested that human endothelial cell-specific molecule-1 (endocan) may be a novel endothelial dysfunction marker. This study aims to investigate the relationship between serum endocan level and the presence and severity of CAD in patients with hypertension.
  
  
  METHODS
  A total of 190 eligible hypertension patients were enrolled in this study. Serum endocan level was measured by enzyme-linked immunosorbent assay. The presence and severity of CAD were evaluated by coronary angiography.
  
  
  RESULTS
  Hypertensive patients with CAD had significantly higher serum endocan level than those without CAD (1.63 ± 0.51 ng/mL vs 1.31 ± 0.65 ng/mL, P < 0.05). Multivariate logistic regression revealed that serum endocan level was independently associated with the presence of CAD (odds ratio, 2.662; 95% confidence interval, 1.560-4.544; P < 0.001). Spearman rank correlation analysis demonstrated that serum endocan level was associated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r = 0.349, P = 0.001).
  
  
  CONCLUSIONS
  Serum endocan level is independently correlated with the presence and severity of CAD in hypertension patients, and those with high endocan level may have an increased risk of developing atherosclerosis.
authors.affiliation: From the Department of Cardiology, Union Hospital, Fujian Medical University; and Fujian Institute of Coronary Artery Disease, Fuzhou, P.R. China.
authors.forename: Chang
authors.initials: C
authors.lastname: Xiong
authors.forename: Zi-wen
authors.initials: ZW
authors.lastname: Zhao
authors.forename: Zhao-yang
authors.initials: ZY
authors.lastname: Chen
authors.forename: Ling-zhen
authors.initials: LZ
authors.lastname: Wu
authors.forename: Yu-kun
authors.initials: YK
authors.lastname: Luo
authors.forename: Fu-dong
authors.initials: FD
authors.lastname: Hu
authors.forename: Chao-gui
authors.initials: CG
authors.lastname: Lin
authors.forename: Liang-long
authors.initials: LL
authors.lastname: Chen
mesh_terms: D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D011509:Proteoglycans / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans