title: Type 2 responses at the interface between immunity and fat metabolism.
abstract: Adipose tissue resident leukocytes are often cast solely as the effectors of obesity and its attendant pathologies; however, recent observations have demonstrated that these cells support and effect 'healthy' physiologic function as well as pathologic dysfunction. Importantly, these two disparate outcomes are underpinned by similarly disparate immune programs; type 2 responses instruct and promote metabolic normalcy, while type 1 responses drive tissue dysfunction. In this Review, we summarize the literature regarding type 2 immunity's role in adipose tissue physiology and allude to its potential therapeutic implications.
authors.affiliation: Cardiovascular Research Institute, University of California San Francisco, San Francisco, 94158-9001, USA.
authors.forename: Justin I
authors.initials: JI
authors.lastname: Odegaard
authors.affiliation: Cardiovascular Research Institute, University of California San Francisco, San Francisco, 94158-9001, USA; Departments of Physiology and Medicine, University of California San Francisco, San Francisco, 94158-9001, USA. Electronic address: ajay.chawla@ucsf.edu.
authors.forename: Ajay
authors.initials: A
authors.lastname: Chawla
mesh_terms: D056704:Adaptive Immunity; D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism; D000818:Animals; D005223:Fats / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007109:Immunity; D007113:Immunity, Innate; D050356:Lipid Metabolism; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
chemical_list: D005223:Fats