title: Coupling-Reagent-Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids.
abstract: A general method for the synthesis of dipeptides has been developed, which does not require any coupling reagents. This method is based on the reaction of readily available HCl salts of amino acid methyl esters with tetrabutylphosphonium amino acid ionic liquids. The isolation procedure of stepwise treatment with AcOH is easy to carry out. The method was extended to the synthesis of tripeptide, tyrosyl-glycyl-glycine, present in IMREG-1, also.
authors.affiliation: Research Institute for Bioscience Products & Fine Chemicals, AminoScience Division, Ajinomoto Co., Inc. Kawasaki, Kanagawa 210-8681 (Japan). shinya_furukawa@ajinomoto.com.
authors.forename: Shinya
authors.initials: S
authors.lastname: Furukawa
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan) http://www.c.s.osakafu-u.ac.jp/∼ryu/
authors.forename: Takahide
authors.initials: T
authors.lastname: Fukuyama
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan) http://www.c.s.osakafu-u.ac.jp/∼ryu/
authors.forename: Akihiro
authors.initials: A
authors.lastname: Matsui
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan) http://www.c.s.osakafu-u.ac.jp/∼ryu/
authors.forename: Mai
authors.initials: M
authors.lastname: Kuratsu
authors.affiliation: Research Institute for Bioscience Products & Fine Chemicals, AminoScience Division, Ajinomoto Co., Inc. Kawasaki, Kanagawa 210-8681 (Japan).
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Nakaya
authors.affiliation: Research Institute for Bioscience Products & Fine Chemicals, AminoScience Division, Ajinomoto Co., Inc. Kawasaki, Kanagawa 210-8681 (Japan).
authors.forename: Takashi
authors.initials: T
authors.lastname: Ineyama
authors.affiliation: Research Institute for Bioscience Products & Fine Chemicals, AminoScience Division, Ajinomoto Co., Inc. Kawasaki, Kanagawa 210-8681 (Japan).
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueda
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan) http://www.c.s.osakafu-u.ac.jp/∼ryu/. ryu@c.s.osakafu-u.ac.jp.
authors.forename: Ilhyong
authors.initials: I
authors.lastname: Ryu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D008222:Lymphokines / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D004151:Dipeptides; C049120:IMREG-1; D007202:Indicators and Reagents; D052578:Ionic Liquids; D008222:Lymphokines; D009842:Oligopeptides; C044757:tyrosyl-glycyl-glycine
keywords: amino acid ionic liquids; coupling-reagent free; dipeptides; tripeptides