title: Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens.
abstract: Twenty-two new highly oxygenated bisabolane-type sesquiterpenoids, pararubin A-V (1-22), were isolated from the whole plant of Parasenecio rubescens. The structure determination of 1-22, including the assignment of their relative configurations, was accomplished by extensive 1D and 2D NMR spectroscopy. The absolute configuration of pararubin A (1) was established by single-crystal X-ray crystallographic analysis. The isolated compounds were evaluated for their cytotoxic effects against three cancer cell lines (B16 mouse melanoma cells, HepG2 human hepatocellular carcinoma cells, and MCF7 human breast adenocarcinoma cells) and for their antimicrobial effects against Staphylococcus aureus, Escherichia coli, and Monilia albicans.
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Hangkonglu 13, Wuhan 430000, People's Republic of China.
authors.forename: An
authors.initials: A
authors.lastname: Jin
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Hangkonglu 13, Wuhan 430000, People's Republic of China.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Wu
authors.affiliation: Department of Pharmacy, Tongji Hospital Affiliated Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China.
authors.forename: Heng-Yi
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Hangkonglu 13, Wuhan 430000, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Hangkonglu 13, Wuhan 430000, People's Republic of China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Hangkonglu 13, Wuhan 430000, People's Republic of China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Hangkonglu 13, Wuhan 430000, People's Republic of China.
authors.forename: Han-Li
authors.initials: HL
authors.lastname: Ruan
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes