title: A new lanostane-type triterpene and sesquiterpene lactones from Vernonia leopoldii and their in vitro cytotoxicity.
abstract: Investigation of the aerial parts of Vernonia leopoldii (Sch. Bip.) Vatke afforded a new lanostane-type triterpene along with known hirsutinolide-type sesquiterpene lactones and flavonoid glycosides, all are identified for the first time in this species. The new compound was identified as lanost-3β, 23S-dihydroxy-22(31)-ene. The structures of the isolated compounds were elucidated based on spectroscopic evidence. The hirsutinolides and the triterpene were evaluated for their cytotoxicity against four human cancer cell lines using MTT assay.
authors.affiliation: a Department of Pharmacognosy , Faculty of Pharmacy, Mansoura University , Mansoura 35516 , Egypt.
authors.forename: Amani M
authors.initials: AM
authors.lastname: Marzouk
authors.affiliation: a Department of Pharmacognosy , Faculty of Pharmacy, Mansoura University , Mansoura 35516 , Egypt.
authors.forename: Osama B
authors.initials: OB
authors.lastname: Abd Elhalim
mesh_terms: D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D035741:Vernonia / Q000737:chemistry*
chemical_list: D006027:Glycosides; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; D014315:Triterpenes; C000610646:lanost-3beta,23S-dihydroxy-22(31)-ene
keywords: Asteraceae; Vernonia leopoldii; cytotoxicity; hirsutinolides; lanostane triterpene