title: Effect of mecobalamin treatment on the recovery of patients with posterior communicating artery aneurysm inducing oculomotor nerve palsy after operation.
abstract: OBJECTIVE
  This research aims to evaluate the effect of mecobalamin treatment on the recovery of patients with posterior communicating artery aneurysm inducing oculomotor nerve palsy after embolization.
  
  
  METHODS
  A total of 56 patients with oculomotor nerve palsy (ONP) attributed to posterior communicating artery (PcomA), were admitted and treated in the Neurology Department of Hubei College of Medicine affiliated to Xiangyan Hospital from July 2007 to January 2013, and 55 of them were followed up as well. Among them 27 patients were given embolization treatment and 28 received embolization + mecobalamin treatment. The recovery condition of ONP were followed and compared one year after the treatment.
  
  
  RESULTS
  All patients were followed up for more than a year. And 31 patients (56.4%) out of 55 achieved complete recovery, 19 (34.5%) attained partial recovery and 5 (9.1%) had no recovery from ONP. Whereas, 20 patients (71.4%) in the embolization + mecobalamin treatment group achieved complete recovery and 11 (40.7%) in the embolization treatment group achieved partial recovery, and the comparative difference was statistically significant (p < 0.05).
  
  
  CONCLUSIONS
  Endovascular is highly efficacious treatment for ONP-inducing PcomA and can promote the recovery of oculomotor nerve palsy after embolism.
authors.affiliation: Department of Neurology, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei, China. zgb1969@126.com.
authors.forename: S-A
authors.initials: SA
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: G-B
authors.initials: GB
authors.lastname: Zhang
authors.forename: Y-H
authors.initials: YH
authors.lastname: Feng
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.forename: P-Y
authors.initials: PY
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D004621:Embolization, Therapeutic / Q000379:methods*; D057510:Endovascular Procedures / Q000639:trends; D005260:Female; D006760:Hospitalization / Q000639:trends; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015840:Oculomotor Nerve Diseases / Q000188:drug therapy* / Q000209:etiology; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D020127:Recovery of Function / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C019476:mecobalamin; D014805:Vitamin B 12