title: Non-contact scanning diffuse correlation tomography system for three-dimensional blood flow imaging in a murine bone graft model.
abstract: A non-contact galvanometer-based optical scanning system for diffuse correlation tomography was developed for monitoring bone graft healing in a murine femur model. A linear image reconstruction algorithm for diffuse correlation tomography was tested using finite-element method based simulated data and experimental data from a femur or a tube suspended in a homogeneous liquid phantom. Finally, the non-contact system was utilized to monitor in vivo blood flow changes prior to and one week after bone graft transplantation within murine femurs. Localized blood flow changes were observed in three mice, demonstrating a potential for quantification of longitudinal blood flow associated with bone graft healing.
authors.affiliation: Institute of Optics, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Songfeng
authors.initials: S
authors.lastname: Han
authors.affiliation: ICFO- Institut de Ciències Fotòniques, 08860, Castelldefels (Barcelona), Spain.
authors.forename: Johannes
authors.initials: J
authors.lastname: Johansson
authors.affiliation: ICFO- Institut de Ciències Fotòniques, 08860, Castelldefels (Barcelona), Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Mireles
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Proctor
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA ; Department of Orthopaedics and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hoffman
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA ; Department of Orthopaedics and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA ; Department of Otolaryngology-Head and Neck Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Vella
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA ; Department of Orthopaedics and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA ; Department of Chemical Engineering, University of Rochester, Rochester, NY 14627, USA ; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors.forename: Danielle S W
authors.initials: DS
authors.lastname: Benoit
authors.affiliation: ICFO- Institut de Ciències Fotòniques, 08860, Castelldefels (Barcelona), Spain.
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA ; Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
keywords: (170.0110) Imaging systems; (170.3660) Light propagation in tissues; (170.6960) Tomography; (170.7050) Turbid media