title: A Single-Site Retrospective, Nonrandomized Study of Accelerated Partial Breast Irradiation Brachytherapy for Early-Stage Breast Cancer Treatment to Evaluate Local Tumor Control, Cosmetic Outcome, and Toxicities.
abstract: To evaluate the efficacy and safety of the accelerated partial breast irradiation brachytherapy with a combination of applicators at a community hospital cancer center.
  
  
  
  Between 2005 and 2009, 120 patients with early-stage breast cancer were being followed after treatment with accelerated partial breast irradiation brachytherapy using MammoSite, single or multilumen balloon, or Contura multilumen balloon. After their lumpectomy surgery, each patient was treated with Ir-192 high-dose rate unit following radiation therapy oncology group 0413 guidelines. The patients had multiple follow-ups at 6 months, 1 year, 2 years, 3 years, or more.
  
  
  
  Based on the Harvard Breast Cosmesis Scale, 95.00% of patients described their cosmetic evaluation as the treated breast essentially the same as the opposite side (excellent) or minimal but identifiable effects were noticed from radiation (good). After a median follow-up of 36 months, the local recurrence rate was 1.66% and a disease-free survival is 98.3%. Forty-two patients reported 85 adverse events, which were fibrosis: 24.70%, hyperpigmentation: 20.00%, radiation skin reaction: 7.05%, seroma: 7.05%, breast pain: 7.05%, erythema: 5.88%, and other events were less than 5.00%. Of all the adverse events recorded, grade 1 to 3 events are 95.29% (n = 81), 2.35% (n = 2), and 2.35% (n = 2). There was no grade 4 or 5 events recorded.
  
  
  
  Our study has shown promising results for delivering radiation with MammoSite, single or multilumen balloon, or Contura multilumen balloon and has been successful in achieving local control in patients with early-stage breast cancer.
authors.affiliation: Radiation Oncology, Saint Vincent's Medical Center, Bridgeport, CT, USA sh.shah@outlook.com.
authors.forename: Shalin
authors.initials: S
authors.lastname: Shah
authors.affiliation: Radiation Oncology, Saint Vincent's Medical Center, Bridgeport, CT, USA.
authors.forename: Erik
authors.initials: E
authors.lastname: Holzwanger
authors.affiliation: Radiation Oncology, Saint Vincent's Medical Center, Bridgeport, CT, USA.
authors.forename: Radhika
authors.initials: R
authors.lastname: Khwaja
authors.affiliation: Radiation Oncology, Saint Vincent's Medical Center, Bridgeport, CT, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Fang
authors.affiliation: Radiation Oncology, Saint Vincent's Medical Center, Bridgeport, CT, USA.
authors.forename: Jazmin
authors.initials: J
authors.lastname: Figueroa-Bodine
authors.affiliation: Radiation Oncology, Saint Vincent's Medical Center, Bridgeport, CT, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Iannuzzi
authors.affiliation: Radiation Oncology, Saint Vincent's Medical Center, Bridgeport, CT, USA.
authors.forename: Chengyu
authors.initials: C
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: accelerated partial breast irradiation; brachytherapy; breast cancer; outcome