title: Effects of swimming associated with risedronate in osteopenic bones: An experimental study with ovariectomized rats.
abstract: Physical activity and risedronate sodium have effects on metabolic bone diseases, maintaining the integrity of bone tissue. Our objective was to evaluate the effects of swimming associated with risedronate as a prophylactic means in osteopenic bone of ovariectomized rats. A total of 24 animals of the Wistar strain were used and separated into four groups containing six animals: Ovariectomy (OVX), ovariectomy and swimming (OVXS), ovariectomy and risedronate (OVXM), ovariectomy, risedronate and swimming (OVXMS). The effectiveness of the treatments were evaluated using the tibia by means of biomechanical, radiographic, histomorphometric analyzes. Statistical analysis was performed by the non-parametric Kruskal-Wallis test (p<0.05). The OVXM and OVXMS groups showed higher values ​​compared to OVX in maximum strength and rigidity. Microscopic analysis showed increased trabecular bone in the OVXM group in relation to the others, and in the OVXMS compared to OVXS. Proximal densitometry in the OVXM and OVXMS groups showed higher values than the OVX and OVXS groups. There were no significant differences in overall densitometry. In conclusion, when comparing the prophylactic means, risedronate was able to preserve bone mass significantly, unlike exercise where an improvement of bone tissue was observed, although not significant, and when swimming and risedronate are combined the result was even better.
authors.affiliation: Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Electronic address: tpaliologo@gmail.com.
authors.forename: Taiane
authors.initials: T
authors.lastname: Paliologo
authors.affiliation: Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Electronic address: roberta_cshimano@hotmail.com.
authors.forename: Roberta Carminati
authors.initials: RC
authors.lastname: Shimano
authors.affiliation: Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Electronic address: acshimano@fmrp.usp.br.
authors.forename: Antônio Carlos
authors.initials: AC
authors.lastname: Shimano
authors.affiliation: Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Electronic address: anapaula@forp.usp.br.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Macedo
authors.affiliation: Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Electronic address: mfalca@hotmail.com.
authors.forename: Maurício José
authors.initials: MJ
authors.lastname: Falcai
authors.affiliation: Department of Morphology, Physiology and Basic Pathology, School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil. Electronic address: jpmissa@forp.usp.br.
authors.forename: João Paulo Mardegan
authors.initials: JPM
authors.lastname: Issa
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D001851:Bone Diseases, Metabolic / Q000188:drug therapy* / Q000517:prevention & control*; D005260:Female; D005269:Femur / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D010052:Ovariectomy; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D000068296:Risedronic Acid / Q000008:administration & dosage*; D013550:Swimming / Q000502:physiology*; D013977:Tibia / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D050071:Bone Density Conservation Agents; D000068296:Risedronic Acid
keywords: Bone diseases; Medicine; Metabolic; Physical exercise