title: Combination of bone allograft, barrier membrane and doxycycline in the treatment of infrabony periodontal defects: A comparative trial.
abstract: OBJECTIVE
  The purpose of the present study was to compare the regenerative potential of noncontained periodontal infrabony defects treated with decalcified freeze-dried bone allograft (DFDBA) and barrier membrane with or without local doxycycline.
  
  
  METHODS
  This study included 48 one- or two-wall infrabony defects from 24 patients (age: 30-65 years) seeking treatment for chronic periodontitis. Defects were randomly divided into two groups and were treated with a combination of DFDBA and barrier membrane, either alone (combined treatment group) or with local doxycycline (combined treatment + doxycycline group). At baseline (before surgery) and 3 and 6 months after surgery, the pocket probing depth (PPD), clinical attachment level (CAL), radiological bone fill (RBF), and alveolar height reduction (AHR) were recorded. Analysis of variance and the Newman-Keuls post hoc test were used for statistical analysis. A two-tailed p-value of less than 0.05 was considered to be statistically significant.
  
  
  RESULTS
  In the combined treatment group, the PPD reduction was 2.00 ± 0.38 mm (32%), CAL gain was 1.25 ± 0.31 mm (17.9%), and RBF was 0.75 ± 0.31 mm (20.7%) after 6 months. In the combined treatment + doxycycline group, these values were 2.75 ± 0.37 mm (44%), 1.5 ± 0.27 mm (21.1%), and 1.13 ± 0.23 mm (28.1%), respectively. AHR values for the groups without and with doxycycline were 12.5% and 9.4%, respectively.
  
  
  CONCLUSIONS
  There was no significant difference in the regeneration of noncontained periodontal infrabony defects between groups treated with DFDBA and barrier membrane with or without doxycycline.
authors.affiliation: Department of Periodontics, Institute of Dental Sciences, Bareilly, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Department of Periodontics, DR. Z.A. Dental College, Aligarh Muslim University, Aligarh, India.
authors.forename: N D
authors.initials: ND
authors.lastname: Gupta
keywords: Bone grafting; Doxycycline; Guided tissue regeneration