title: A novel gene THSD7A is associated with obesity.
abstract: Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (P⩽3.75 × 10(-5)), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P=2.88 × 10(-5), 8.922 × 10(-6) and 2.504 × 10(-9) in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: S
authors.initials: S
authors.lastname: Nizamuddin
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: P
authors.initials: P
authors.lastname: Govindaraj
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: S
authors.initials: S
authors.lastname: Saxena
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: M
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authors.lastname: Kashyap
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: A
authors.initials: A
authors.lastname: Mishra
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.affiliation: School of Life Sciences, Manipal University, Karnataka, India.
authors.forename: H
authors.initials: H
authors.lastname: Rotti
authors.affiliation: School of Life Sciences, Manipal University, Karnataka, India.
authors.forename: R
authors.initials: R
authors.lastname: Raval
authors.affiliation: Shri Dharmasthala Manjunatheshwara College of Ayurveda, Karnataka, India.
authors.forename: J
authors.initials: J
authors.lastname: Nayak
authors.affiliation: Shri Dharmasthala Manjunatheshwara College of Ayurveda, Karnataka, India.
authors.forename: B K
authors.initials: BK
authors.lastname: Bhat
authors.affiliation: Shri Dharmasthala Manjunatheshwara College of Ayurveda, Karnataka, India.
authors.forename: B V
authors.initials: BV
authors.lastname: Prasanna
authors.affiliation: Sinhgad College of Engineering, Maharashtra, India.
authors.forename: V R
authors.initials: VR
authors.lastname: Dhumal
authors.affiliation: Sinhgad College of Engineering, Maharashtra, India.
authors.forename: S
authors.initials: S
authors.lastname: Bhale
authors.affiliation: Sinhgad College of Engineering, Maharashtra, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Joshi
authors.affiliation: Sinhgad College of Engineering, Maharashtra, India.
authors.forename: A P
authors.initials: AP
authors.lastname: Dedge
authors.affiliation: Foundation for Revitalization of Local Health Traditions, Karnataka, India.
authors.forename: R
authors.initials: R
authors.lastname: Bharadwaj
authors.affiliation: Foundation for Revitalization of Local Health Traditions, Karnataka, India.
authors.forename: G G
authors.initials: GG
authors.lastname: Gangadharan
authors.affiliation: Department of Statistics, Manipal University, Karnataka, India.
authors.forename: S
authors.initials: S
authors.lastname: Nair
authors.affiliation: School of Life Sciences, Manipal University, Karnataka, India.
authors.forename: P M
authors.initials: PM
authors.lastname: Gopinath
authors.affiliation: Interdisciplinary School of Health Sciences, University of Pune, Maharashtra, India.
authors.forename: B
authors.initials: B
authors.lastname: Patwardhan
authors.affiliation: Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Karnataka, India.
authors.forename: P
authors.initials: P
authors.lastname: Kondaiah
authors.affiliation: School of Life Sciences, Manipal University, Karnataka, India.
authors.forename: K
authors.initials: K
authors.lastname: Satyamoorthy
authors.affiliation: School of Life Sciences, Manipal University, Karnataka, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Valiathan
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: K
authors.initials: K
authors.lastname: Thangaraj
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D006801:Humans; D007194:India / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D019699:Thrombospondins / Q000235:genetics*; D044465:White People / Q000235:genetics* / Q000706:statistics & numerical data
chemical_list: C546399:THSD7A protein, human; D019699:Thrombospondins