title: Long-term Follow-up After Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis.
abstract: OBJECTIVE
  Transcatheter aortic valve implantation is used as an alternative to surgical valve replacement in patients with severe aortic stenosis who are considered high-surgical-risk or inoperable. Two of the main areas of uncertainty in this field are valve durability and long-term survival.
  
  
  METHODS
  This prospective single-center registry study from a tertiary hospital included all consecutive patients who underwent percutaneous aortic valve implantation between 2008 and 2012. Clinical follow-up lasted a minimum of 2.5 years and a maximum of 6.5 years. Valve Academic Research Consortium-2 definitions were used.
  
  
  RESULTS
  Seventy-nine patients were included, with an immediate success rate of 94.9%. The median survival was 47.6 months (95% confidence intervals, 37.4-57.9 months), ie, 4 years. One quarter of deaths occurred in the first month, and most were of cardiovascular cause. After the first month, most deaths were due to noncardiovascular causes. The mean values of valve gradients did not increase during follow-up. The cumulative rate of prosthetic valve dysfunction was 15.3%, with no cases of repeat valve replacement.
  
  
  CONCLUSIONS
  Half of the patients with aortic stenosis who underwent transcatheter aortic valve implantation were alive 4 years after the procedure. There was a 15.3% prosthetic valve dysfunction rate in cumulative follow-up, with no cases of repeat valve replacement.
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain. Electronic address: salinas.pablo@gmail.com.
authors.forename: Pablo
authors.initials: P
authors.lastname: Salinas
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Raúl
authors.initials: R
authors.lastname: Moreno
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Calvo
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Sánchez-Recalde
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Jiménez-Valero
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Galeote
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: López-Fernández
authors.affiliation: Servicio de Cirugía Cardiaca, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Ulises
authors.initials: U
authors.lastname: Ramírez
authors.affiliation: Servicio de Cirugía Vascular, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Riera
authors.affiliation: Servicio de Cardiología, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Plaza
authors.affiliation: Servicio de Anestesia y Reanimación, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Isidro
authors.initials: I
authors.lastname: Moreno
authors.affiliation: Servicio de Cirugía Cardiaca, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Mesa
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: López-Sendón
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D002423:Cause of Death / Q000639:trends; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate / Q000639:trends; D013997:Time Factors
keywords: Aortic stenosis; Definiciones Valve Academic Research Consortium; Estenosis aórtica; Implante percutáneo de válvula aórtica; Reemplazo percutáneo de válvula aórtica; Transcatheter aortic valve implantation; Transcatheter aortic valve replacement; Valve Academic Research Consortium definitions; Valvular heart disease; Valvulopatía