title: Hyperferritinemic syndrome: Still's disease and catastrophic antiphospholipid syndrome triggered by fulminant Chikungunya infection: a case report of two patients.
abstract: There are four medical conditions characterized by high levels of ferritin, the macrophage activation syndrome (MAS), adult onset Still' s disease (AOSD), catastrophic antiphospholipid syndrome (CAPS), and septic shock, that share similar clinical and laboratory features, suggesting a common pathogenic mechanism. This common syndrome entity is termed "the hyperferritinemic syndrome." Here, we describe two different cases of hyperferritinemic syndrome triggered by Chikungunya fever virus infection: a 21-year-old female with SLE and a 32-year-old male patient who developed AOSD after the coinfection of dengue and Chikungunya viruses.
authors.affiliation: Department of Internal Medicine, CES University, School of Medicine, Medellín-Colombia and Fundación Valle del Lili, Cali, Colombia.
authors.forename: Juan-Felipe
authors.initials: JF
authors.lastname: Betancur
authors.affiliation: Department of Internal Medicine, CES University, School of Medicine, Medellín-Colombia and Fundación Valle del Lili, Cali, Colombia.
authors.forename: Erika-Paola
authors.initials: EP
authors.lastname: Navarro
authors.affiliation: Rheumatology Unit. Fundación Valle del Lili, Icesi University, Cali, Colombia.
authors.forename: Alex
authors.initials: A
authors.lastname: Echeverry
authors.affiliation: Infectious Diseases Unit. Fundación Valle del Lili, Cali, Colombia.
authors.forename: Pablo A
authors.initials: PA
authors.lastname: Moncada
authors.affiliation: Rheumatology Unit. Fundación Valle del Lili, Icesi University, Cali, Colombia.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Cañas
authors.affiliation: Rheumatology Unit. Fundación Valle del Lili, Icesi University, Cali, Colombia. gtobon1@yahoo.com.|Laboratory of Immunology. Fundación Valle del Lili, Cra. 98 18-49, Cali, Colombia. gtobon1@yahoo.com.
authors.forename: Gabriel J
authors.initials: GJ
authors.lastname: Tobón
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000209:etiology*; D002386:Cataract / Q000151:congenital* / Q000175:diagnosis / Q000209:etiology; D065632:Chikungunya Fever / Q000150:complications*; D003715:Dengue / Q000150:complications*; D005260:Female; D005293:Ferritins / Q000097:blood; D005334:Fever; D006801:Humans; D019189:Iron Metabolism Disorders / Q000151:congenital* / Q000175:diagnosis / Q000209:etiology; D008180:Lupus Erythematosus, Systemic; D008297:Male; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis / Q000209:etiology*; D055815:Young Adult
chemical_list: D005293:Ferritins
keywords: Adult onset Still’s disease; Catastrophic antiphospholipid syndrome; Chikungunya virus infection; Ferritin; Hyperferritinemic syndrome