title: Toward live-cell imaging of dopamine neurotransmission with fluorescent neurotransmitter analogues.
abstract: We report a novel 'fluorescent dopamine' that possesses essential features of natural dopamine. Our method is simple and is readily extended to monoamine neurotransmitters such as L-norepinephrine, serotonin and GABA, providing a more practical approach. Because of its compatibility with sensitive fluorescent measurements, we envisage that our approach will have a broad range of applications in neural research.
authors.affiliation: Department of Applied Chemistry and Institute of Molecular Science, National Chiao Tung University, Hsinchu 30010, Taiwan. ianliau@mail.nctu.edu.tw ykl@cc.nctu.edu.tw.
authors.forename: Hui-Jen
authors.initials: HJ
authors.lastname: Lin
authors.forename: Hsueh-Han
authors.initials: HH
authors.lastname: Lu
authors.forename: Kuan-Miao
authors.initials: KM
authors.lastname: Liu
authors.forename: Chi-Min
authors.initials: CM
authors.lastname: Chau
authors.forename: You-Zung
authors.initials: YZ
authors.lastname: Hsieh
authors.forename: Yaw-Kuen
authors.initials: YK
authors.lastname: Li
authors.forename: Ian
authors.initials: I
authors.lastname: Liau
mesh_terms: D000818:Animals; D001692:Biological Transport; D016466:CHO Cells; D003412:Cricetulus; D004298:Dopamine / Q000378:metabolism*; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005470:Fluorometry / Q000379:methods; D057054:Molecular Imaging / Q000379:methods*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D016716:PC12 Cells; D051381:Rats; D009435:Synaptic Transmission
chemical_list: D005456:Fluorescent Dyes; D018377:Neurotransmitter Agents; D016650:Fluorescein-5-isothiocyanate; D004298:Dopamine