title: Mazabraud's syndrome and thyroid cancer, a very rare and confusing association: a case report.
abstract: BACKGROUND
  Mazabraud's syndrome is defined as the association between fibrous dysplasia and intramuscular myxomas. The syndrome was first described in 1967 and, up until now, less than 100 cases have been reported worldwide. Here we report the association between this rare syndrome and thyroid cancer. When a malignant disease occurs in a patient affected by this syndrome, the differential diagnosis between benign and malignant bone lesions should be undertaken carefully.
  
  
  METHODS
  We report the case of a 57-year-old Caucasian male, admitted for diffuse bone pain localized in the left leg and for the presence of an indolent, slow-growing mass in the left shoulder. The patient also presented with a thyroid nodule, highly suggestive of a malignancy. The radiologic examination showed multiple osteolytic lesions. The suspicion of multiple myeloma or bone metastases arising from a thyroid cancer was considered. Electrophoresis of proteins was negative and therefore excluded the diagnosis of multiple myeloma; the thyroid surgery was indicated. Thyroidectomy confirmed the papillary thyroid carcinoma, and the bone lesions were considered to be metastases from the thyroid cancer. After surgery, under thyroid-stimulated hormonal conditions, the patient underwent radioiodine therapy and a post-therapy radioiodine whole body scan. The lack of radioiodine uptake, both in the bone lesions and shoulder mass, suggested the possibility of less differentiated, non-avid radioiodine lesions, or the absence of any relation between pathologies. Considering the low level of the specific tumor marker, thyroglobulin, a bone biopsy and resection of the shoulder mass were indicated. The final diagnosis was intramuscular myxoma with polyostotic fibrous dysplasia in the deltoid muscle (Mazabraud's syndrome). A completely incidental cerebral tumor lesion was also discovered.
  
  
  CONCLUSIONS
  During the evolution of a malignant disease, Mazabraud's syndrome, known as the association of intramuscular myxoma with fibrous dysplasia, should be considered in the differential diagnosis of bone metastasis. This is the first report in the literature of Mazabraud's syndrome occurring in a patient with thyroid cancer.
authors.affiliation: Department of Endocrinology and Nuclear Medicine, Institute of Oncology "Prof. Dr. Ion Chiricuta" 34-36 Republicii, 400015, Cluj-Napoca, Romania. doina.piciu@gmail.com.|University of Medicine and Pharmacy "Iuliu Hatieganu" 6-8 V. Babes, 400012, Cluj-Napoca, Romania. doina.piciu@gmail.com.
authors.forename: Doina
authors.initials: D
authors.lastname: Piciu
authors.affiliation: University of Medicine and Pharmacy "Iuliu Hatieganu" 6-8 V. Babes, 400012, Cluj-Napoca, Romania. elena.barbus@gmail.com.
authors.forename: Elena
authors.initials: E
authors.lastname: Barbus
authors.affiliation: University of Medicine and Pharmacy "Iuliu Hatieganu" 6-8 V. Babes, 400012, Cluj-Napoca, Romania. piciuandra@gmail.com.|Department of Oncology, Institute of Oncology "Prof. Dr. Ion Chiricuta" 34-36 Republicii, 400015, Cluj-Napoca, Romania. piciuandra@gmail.com.
authors.forename: Andra
authors.initials: A
authors.lastname: Piciu
authors.affiliation: Department of Pathology, Institute of Oncology "Prof. Dr. Ion Chiricuta" 34-36 Republicii, 400015, Cluj-Napoca, Romania. office@iocn.ro.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Fetica
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary; D002277:Carcinoma / Q000150:complications* / Q000175:diagnosis; D002291:Carcinoma, Papillary; D003937:Diagnosis, Differential; D005357:Fibrous Dysplasia of Bone / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000150:complications*; D009232:Myxoma / Q000150:complications*; D011877:Radionuclide Imaging; D013577:Syndrome; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000150:complications* / Q000175:diagnosis