title: Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome.
abstract: BACKGROUND
  Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome (MetS).
  
  
  METHODS
  Serum arginase activity, and nitrite and uric acid levels were measured in 48 women with MetS and in 20 healthy controls. The correlation of these parameters with components of MetS was also evaluated.
  
  
  RESULTS
  Our data show statistically higher arginase activity and uric acid levels but lower nitrite levels in women with MetS compared to controls. Serum uric acid levels were negatively correlated with HDL cholesterol, nitrite levels and positively with Body Mass Index, waist to hip ratio, triglyceride and total cholesterol levels, systolic blood pressure, Homeostasis Model Assessment-Insulin Resistance-Index, serum arginase activity, and LDL-cholesterol levels in women with MetS.
  
  
  CONCLUSIONS
  Results of the present study suggest that serum uric acid levels may contribute to the pathogenesis of MetS through a process mediated by arginase pathway, and serum arginase activity and nitrite and uric acid levels can be used as indicators of CVD in women with MetS.
authors.affiliation: Department of Biochemistry, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Uslu
authors.affiliation: Department of Nutrition and Dietetics, School of Healthy, Artvin Coruh University, Artvin, Turkey. eda_ozcelik@artvin.edu.tr.
authors.forename: E
authors.initials: E
authors.lastname: Ozcelik
authors.affiliation: Department of Endocrinology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Kebapci
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
authors.forename: H E
authors.initials: HE
authors.lastname: Temel
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Demirci
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Ergun
authors.affiliation: Department of Biostatistics, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Demirustu
mesh_terms: D000328:Adult; D001119:Arginase / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D014527:Uric Acid; D001119:Arginase
keywords: Arginase pathway; Metabolic syndrome; Serum uric acid levels