title: Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes.
abstract: Despite the remarkable benefits obtained following the introduction of the first-generation drug-eluting stent (DES), concerns were raised over its long-term safety, particularly with regard to very late (beyond 1 year) stent thrombosis. Newer-generation DESs have been developed to overcome this limitation using novel stent platforms, new drugs, more biocompatible durable polymers, and bioabsorbable polymers or backbones. To date, new-generation DESs have virtually replaced the use of first-generation DESs worldwide. In this review article, we discuss in detail the design, pharmacology, and mechanism of action of the newer-generation permanent and bioresorbable everolimus-eluting platforms. Furthermore, we present and evaluate the current evidence on the performance and safety of these devices compared to those of other available stent platforms.
authors.affiliation: National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Vasileios F
authors.initials: VF
authors.lastname: Panoulas
authors.affiliation: Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A Wiener Cardiovascular Institute, The Icahn School of Medicine at Mount Sinai, New York NY, USA.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Mastoris
authors.affiliation: National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Klio
authors.initials: K
authors.lastname: Konstantinou
authors.affiliation: Cardiology Department, Bolognini Hospital Seriate, Seriate (BG), Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Tespili
authors.affiliation: Cardiology Department, Bolognini Hospital Seriate, Seriate (BG), Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Ielasi
keywords: PCI; angioplasty; outcome; stent