title: Non-covalent phosphorylcholine coating reduces protein adsorption and phagocytic uptake of microparticles.
abstract: Phosphorylcholine co-polymer was assembled on model polystyrene microparticles through a simple, widely-applicable ethanol coating process. The coating rendered particles resistant to protein adsorption and phagocytosis by macrophages, making it useful for a range of biological applications.
authors.affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr. NW, Atlanta, GA 30332, USA. julie.champion@chbe.gatech.edu.
authors.forename: Anusha
authors.initials: A
authors.lastname: Garapaty
authors.forename: Julie A
authors.initials: JA
authors.lastname: Champion
mesh_terms: D000327:Adsorption; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D010587:Phagocytosis; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000494:pharmacology*; D011137:Polystyrenes / Q000494:pharmacology*; D013499:Surface Properties
chemical_list: D001798:Blood Proteins; C000607977:MPCAM polymer; D011109:Polymethacrylic Acids; D011137:Polystyrenes; D010767:Phosphorylcholine