title: Metal-Free Oxidative C-C Bond Formation through C-H Bond Functionalization.
abstract: The formation of C-C bonds embodies the core of organic chemistry because of its fundamental application in generation of molecular diversity and complexity. C-C bond-forming reactions are well-known challenges. To achieve this goal through direct functionalization of C-H bonds in both of the coupling partners represents the state-of-the-art in organic synthesis. Oxidative C-C bond formation obviates the need for prefunctionalization of both substrates. This Minireview is dedicated to the field of C-C bond-forming reactions through direct C-H bond functionalization under completely metal-free oxidative conditions. Selected important developments in this area have been summarized with representative examples and discussions on their reaction mechanisms.
authors.affiliation: Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn Strasse 11, 44227 Dortmund (Germany).
authors.forename: Rishikesh
authors.initials: R
authors.lastname: Narayan
authors.affiliation: Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn Strasse 11, 44227 Dortmund (Germany).|Present Address: API Small Molecule Process Research and Development, Janssen Pharmaceutica NV, Turnhotsweg 30, 2340 Beerse (Belgium).
authors.forename: Kiran
authors.initials: K
authors.lastname: Matcha
authors.affiliation: Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn Strasse 11, 44227 Dortmund (Germany). andrey.antonchick@mpi-dortmund.mpg.de.|Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund, Otto-Hahn Strasse 6, 44221 Dortmund (Germany). andrey.antonchick@mpi-dortmund.mpg.de.
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Antonchick
keywords: CC coupling; CH activation; hypervalent iodine; metal-free; oxidative coupling