title: Genistein reduces the noxious effects of in utero bisphenol A exposure on the rat prostate gland at weaning and in adulthood.
abstract: Bisphenol A (BPA) is one hormonally active chemical with potential deleterious effects on reproductive organs, including breast and prostate. In contrast, genistein (GEN) is the major phytoestrogen of soy that presents potential protective effects against hormone-dependent cancers, including that of the prostate. Thus, pregnant Sprague-Dawley rats were treated with BPA at 25 or 250 μg/kg/day by gavage from gestational day (GD) 10-21 with or without dietary GEN at 250 mg/kg/chow (∼5.5 mg/kg/day). Then, male offspring from different litters were euthanized on post-natal day (PND) 21 and 180. At PND21, BPA 25 exposure induced early prostatic changes while dietary GEN attenuated some deleterious actions this xenoestrogen on epithelial cell proliferation levels, androgen receptor expression and prostatic architecture in male offspring. At PND180, a significant increase in incidence of prostatic multifocal inflammation/reactive hyperplasia and atypical hyperplasia were observed in male offspring from dams that received BPA 25. On the other hand, maternal GEN feeding attenuated some the adverse effects of BPA 25 on prostate disease at late-in-life. This way, the present findings point to preventive action of dietary GEN on deleterious effects of gestational BPA exposure in both early and late prostate development in offspring F1.
authors.affiliation: UNESP - Univ. Estadual Paulista, School of Medicine, Department of Pathology, Botucatu, SP, 18618-970, Brazil.
authors.forename: Bruna Dias
authors.initials: BD
authors.lastname: Bernardo
authors.affiliation: UNESP - Univ. Estadual Paulista, Institute of Biosciences, Department of Morphology, Botucatu, SP, 18618-970, Brazil.
authors.forename: Joyce Zalotti
authors.initials: JZ
authors.lastname: Brandt
authors.affiliation: UNESP - Univ. Estadual Paulista, School of Medicine, Department of Pathology, Botucatu, SP, 18618-970, Brazil.
authors.forename: Tony Fernando
authors.initials: TF
authors.lastname: Grassi
authors.affiliation: UNESP - Univ. Estadual Paulista, Institute of Biosciences, Department of Morphology, Botucatu, SP, 18618-970, Brazil.
authors.forename: Lívia Teresa R
authors.initials: LT
authors.lastname: Silveira
authors.affiliation: UNESP - Univ. Estadual Paulista, Institute of Biosciences, Department of Morphology, Botucatu, SP, 18618-970, Brazil.
authors.forename: Wellerson Rodrigo
authors.initials: WR
authors.lastname: Scarano
authors.affiliation: UNESP - Univ. Estadual Paulista, Institute of Biosciences, Department of Morphology, Botucatu, SP, 18618-970, Brazil. Electronic address: barbisan@ibb.unesp.br.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Barbisan
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005260:Female; D019833:Genistein / Q000627:therapeutic use*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D010636:Phenols / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity; D048789:Phytoestrogens / Q000627:therapeutic use*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000378:metabolism; D013047:Specific Pathogen-Free Organisms; D014886:Weaning; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D019833:Genistein; D010636:Phenols; D048789:Phytoestrogens; D011944:Receptors, Androgen; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Genistein; Gestation; Prevention; Prostate development; Prostatic lesions in adulthood