title: Associations between low levels of serum uric acid and cardiometabolic parameters.
abstract: BACKGROUND
  Elevated serum uric acid (SUA) levels are associated with increased cardiovascular risk.
  
  
  OBJECTIVE
  To evaluate the association between SUA levels and cardiometabolic parameters.
  
  
  METHODS
  SUA levels and metabolic parameters were evaluated in 139 subjects, divided into low (<5 mg/dl) and high SUA group (≥5 mg/dl).
  
  
  RESULTS
  In low SUA group, SUA levels directly correlated with creatinine, body mass index, waist circumference, blood pressure, glucose and insulin levels, triglyceride and C-reactive protein levels. In high SUA group, SUA levels directly correlated with body weight, triglyceride, C-reactive protein, and inversely correlated with HDL-cholesterol concentrations.
  
  
  CONCLUSIONS
  High SUA levels were linked with several cardiometabolic parameters, and low SUA levels were linearly correlated with recognized cardiovascular risk factors. Therefore, increasing SUA levels - even at low concentration - could be associated with higher cardiovascular risk. Thus the range of normality for SUA level should be further analysed.
authors.affiliation: a University of L'Aquila, Department of Life, Health and Environmental Sciences, San Salvatore Hospital , L'Aquila , Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Ciarla
authors.affiliation: a University of L'Aquila, Department of Life, Health and Environmental Sciences, San Salvatore Hospital , L'Aquila , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Giorgini
authors.affiliation: a University of L'Aquila, Department of Life, Health and Environmental Sciences, San Salvatore Hospital , L'Aquila , Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Struglia
authors.affiliation: a University of L'Aquila, Department of Life, Health and Environmental Sciences, San Salvatore Hospital , L'Aquila , Italy.
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Striuli
authors.affiliation: a University of L'Aquila, Department of Life, Health and Environmental Sciences, San Salvatore Hospital , L'Aquila , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Necozione
authors.affiliation: a University of L'Aquila, Department of Life, Health and Environmental Sciences, San Salvatore Hospital , L'Aquila , Italy.
authors.forename: Giovambattista
authors.initials: G
authors.lastname: Desideri
authors.affiliation: a University of L'Aquila, Department of Life, Health and Environmental Sciences, San Salvatore Hospital , L'Aquila , Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Properzi
authors.affiliation: a University of L'Aquila, Department of Life, Health and Environmental Sciences, San Salvatore Hospital , L'Aquila , Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ferri
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood / Q000378:metabolism; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Cardiovascular risk; range of normality; uric acid