title: [Descriptive study of bone and joint infections in children in times of community-acquired methicillin- resistant Staphylococcus aureus (CA-MRSA)].
abstract: BACKGROUND
  Bone and joint infections (BJI) are relatively common in children, and community -acquired methicillin resistant Staphylococcus aureus (CA-MRSA) is the leading cause in some countries.
  
  
  OBJECTIVE
  To evaluate epidemiological data, clinical and microbiological features and outcome of BJI.
  
  
  METHODS
  A prospective descriptive study was conducted.
  
  
  RESULTS
  40 patients (p) completed the study. Bacterial cultures were positives in 30 p (75%): CA-MRSA was found in 19 p, methicillin-sensitive S. aureus in 6 p, and others in 5 p. Cultures were negatives in 10 p (25%). Median treatment duration was 28 days (r: 21-40 d); Analyzing patients with CA-MRSA positive cultures separately, initial CRP was higher (Md 76 vs 50 mg/L, p < 0.02), normalization occurred later (Md 14 days vs 7days, p < 0.03), and duration of treatment (Md 32 days vs 23, p < 0.004) as well as hospital stay (Md 9 days vs 7, p = 0.12) were longer. Sequelae were present in 3 p and 1 relapsed: All of them with CA-SAMR.
  
  
  CONCLUSIONS
  CA-MRSA was the leading cause of BJI and was associated with higher CRP on admission, later normalization and longer treatment duration. Complications as drainage requirement, and sequelae were common in those p.
authors.forename: María T
authors.initials: MT
authors.lastname: Rosanova
authors.forename: Griselda
authors.initials: G
authors.lastname: Beberían
authors.forename: Rosa
authors.initials: R
authors.lastname: Bologna
authors.forename: Sandra
authors.initials: S
authors.lastname: Giménez
authors.forename: Claudia
authors.initials: C
authors.lastname: Sarkis
authors.forename: Ana
authors.initials: A
authors.lastname: Buchovsky
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Pérez-M D
authors.forename: Jose
authors.initials: J
authors.lastname: Pinheiro
authors.forename: Roberto
authors.initials: R
authors.lastname: Lede
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology*; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents