title: Effect of the exposure to maternal smoking during pregnancy and childhood on the body mass index until adolescence.
abstract: OBJECTIVE Investigate the effect of exposure to smoking during pregnancy and early childhood on changes in the body mass index (BMI) from birth to adolescence. METHODS A population-based cohort of children (0-5 years old) from Cuiabá, Midwest Brazil, was assessed in 1999-2000 (n = 2,405). Between 2009 and 2011, the cohort was re-evaluated. Information about birth weight was obtained from medical records, and exposure to smoking during pregnancy and childhood was assessed at the first interview. Linear mixed effects models were used to estimate the association between exposure to maternal smoking during pregnancy and preschool age, and the body mass index of children at birth, childhood and adolescence. RESULTS Only 11.3% of the mothers reported smoking during pregnancy, but most of them (78.2%) also smoked during early childhood. Among mothers who smoked only during pregnancy (n = 59), 97.7% had smoked only in the first trimester. The changes in body mass index at birth and in childhood were similar for children exposed and those not exposed to maternal smoking. However, from childhood to adolescence the rate of change in the body mass index was higher among those exposed only during pregnancy than among those who were not exposed. CONCLUSIONS Exposure to smoking only during pregnancy, especially in the first trimester, seems to affect changes in the body mass index until adolescence, supporting guidelines that recommend women of childbearing age to stop smoking.
authors.affiliation: Instituto de Saúde Coletiva, Universidade Federal de Mato Grosso, Cuiabá, MT, Brasil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Muraro
authors.affiliation: Departamento de Alimentos e Nutrição, Universidade Federal de Mato Grosso, Cuiabá, MT, Brasil.
authors.forename: Regina Maria Veras
authors.initials: RM
authors.lastname: Gonçalves-Silva
authors.affiliation: Departamento de Alimentos e Nutrição, Universidade Federal de Mato Grosso, Cuiabá, MT, Brasil.
authors.forename: Márcia Gonçalves
authors.initials: MG
authors.lastname: Ferreira
authors.affiliation: Departamento de Epidemiologia, Instituto de Medicina Social, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Gulnar Azevedo E
authors.initials: GA
authors.lastname: Silva
authors.affiliation: Departamento de Epidemiologia, Instituto de Medicina Social, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Rosely
authors.initials: R
authors.lastname: Sichieri
mesh_terms: D000293:Adolescent; D001724:Birth Weight; D001827:Body Height; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D012907:Smoking / Q000503:physiopathology*; D012959:Socioeconomic Factors