title: Cortical neuroprosthetics from a clinical perspective.
abstract: Recent pilot clinical studies have demonstrated that subjects with severe disorders of movement and communication can exert direct neural control over assistive devices using invasive Brain-Machine Interface (BMI) technology, also referred to as 'cortical neuroprosthetics'. These important proof-of-principle studies have generated great interest among those with disability and clinicians who provide general medical, neurological and/or rehabilitative care. Taking into account the perspective of providers who may be unfamiliar with the field, we first review the clinical goals and fundamentals of invasive BMI technology, and then briefly summarize the vast body of basic science research demonstrating its feasibility. We emphasize recent translational progress in the target clinical populations and discuss translational challenges and future directions.
authors.affiliation: Neurology & Rehabilitation Service, San Francisco VA Medical Center, United States.
authors.forename: Adelyn P
authors.initials: AP
authors.lastname: Tsu
authors.affiliation: Department of Neurology, University of California, San Francisco, United States.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Burish
authors.affiliation: Neurology & Rehabilitation Service, San Francisco VA Medical Center, United States; Department of Neurology, University of California, San Francisco, United States.
authors.forename: Jason
authors.initials: J
authors.lastname: GodLove
authors.affiliation: Neurology & Rehabilitation Service, San Francisco VA Medical Center, United States; Department of Neurology, University of California, San Francisco, United States; Center for Neural Engineering and Prosthetics, University of California, San Francisco & University of California, Berkeley, United States. Electronic address: karunesh.ganguly@ucsf.edu.
authors.forename: Karunesh
authors.initials: K
authors.lastname: Ganguly
mesh_terms: D062207:Brain-Computer Interfaces / Q000639:trends*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004567:Electrodes, Implanted; D056228:Feedback, Sensory; D006801:Humans; D009069:Movement Disorders / Q000503:physiopathology / Q000534:rehabilitation*; D019736:Prostheses and Implants; D020127:Recovery of Function; D057170:Translational Research, Biomedical / Q000639:trends*; D014584:User-Computer Interface