title: The Role of αA-Crystallin in Experimental Autoimmune Uveitis.
abstract: Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, αA-crystallin has been found to be upregulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of αA-crystallin and discuss its functional mechanisms in EAU.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: Z-F
authors.initials: ZF
authors.lastname: Wang
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Huang
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.forename: L
authors.initials: L
authors.lastname: Gong
authors.forename: X
authors.initials: X
authors.lastname: Tang
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Luo
authors.forename: W
authors.initials: W
authors.lastname: Ji
authors.forename: W-F
authors.initials: WF
authors.lastname: Hu
authors.forename: Z
authors.initials: Z
authors.lastname: Woodward
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Liu
authors.forename: Q D
authors.initials: QD
authors.lastname: Nguyen
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, #54 Xianlie South Road, Sun Yat-sen University, Guangzhou 510060, China. dwli1688@hotmail.com.
authors.forename: D W-C
authors.initials: DW
authors.lastname: Li
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D045304:Cytochromes c / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress; D010786:Photoreceptor Cells / Q000276:immunology / Q000378:metabolism; D012160:Retina / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism; D014605:Uveitis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D038202:alpha-Crystallin A Chain / Q000235:genetics / Q000378:metabolism*
chemical_list: D016207:Cytokines; D051193:Toll-Like Receptors; D038202:alpha-Crystallin A Chain; D045304:Cytochromes c