title: Therapeutic potentials of human adipose-derived stem cells on the mouse model of Parkinson's disease.
abstract: The treatment of Parkinson's disease (PD) using stem cells has long been the focus of many researchers, but the ideal therapeutic strategy has not yet been developed. The consistency and high reliability of the experimental results confirmed by animal models are considered to be a critical factor in the stability of stem cell transplantation for PD. Therefore, the aim of this study was to investigate the preventive and therapeutic potential of human adipose-derived stem cells (hASC) for PD and was to identify the related factors to this therapeutic effect. The hASC were intravenously injected into the tail vein of a PD mouse model induced by 6-hydroxydopamine. Consequently, the behavioral performances were significantly improved at 3 weeks after the injection of hASC. Additionally, dopaminergic neurons were rescued, the number of structure-modified mitochondria was decreased, and mitochondrial complex I activity was restored in the brains of the hASC-injected PD mouse model. Overall, this study underscores that intravenously transplanted hASC may have therapeutic potential for PD by recovering mitochondrial functions.
authors.affiliation: Research Division, Department of Structure and Function of Neural Network, Korea Brain Research Institute, Daegu, Korea.
authors.forename: Hee Soon
authors.initials: HS
authors.lastname: Choi
authors.affiliation: Research Division, Department of Neural Development and Disease, Korea Brain Research Institute, Daegu, Korea.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Neuroscience Research Institute, Gachon University, Incheon, Korea.
authors.forename: Jin-Hwan
authors.initials: JH
authors.lastname: Oh
authors.affiliation: K-STEM CELL Institute, Seoul, Korea.
authors.forename: Hyeong-Geun
authors.initials: HG
authors.lastname: Park
authors.affiliation: K-STEM CELL Institute, Seoul, Korea.
authors.forename: Jeong Chan
authors.initials: JC
authors.lastname: Ra
authors.affiliation: Neuroscience Research Institute, Gachon University, Incheon, Korea; Department of Pharmacology, Gachon University, Incheon, Korea. Electronic address: keuna705@gachon.ac.kr.
authors.forename: Keun-A
authors.initials: KA
authors.lastname: Chang
authors.affiliation: Department of Pharmacology, Gachon University, Incheon, Korea; Korea Brain Research Institute, Daegu, Korea; Department of Pharmacology, Seoul National University Medical College, Seoul, Korea. Electronic address: yhsuh@snu.ac.kr.
authors.forename: Yoo-Hun
authors.initials: YH
authors.lastname: Suh
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D004195:Disease Models, Animal; D059290:Dopaminergic Neurons / Q000473:pathology; D042967:Electron Transport Complex I / Q000172:deficiency; D006801:Humans; D008297:Male; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000473:pathology; D028361:Mitochondrial Diseases / Q000209:etiology / Q000628:therapy; D016627:Oxidopamine; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells
chemical_list: D016627:Oxidopamine; D042967:Electron Transport Complex I
keywords: 6-OHDA; Human adipose-derived stem cells; Mitochondria; Parkinson's disease