title: Antischistosomal Activity of Oxindolimine-Metal Complexes.
abstract: In recent years, a class of oxindole-copper and -zinc complex derivatives have been reported as compounds with efficient proapoptotic activity toward different tumor cells (e.g., neuroblastomas, melanomas, monocytes). Here we assessed the efficacy of synthesized oxindole-copper(II), -zinc(II), and -vanadyl (VO(2+)) complexes against adult Schistosoma mansoni worms. The copper(II) complexes (50% inhibitory concentrations of 30 to 45 μM) demonstrated greater antischistosomal properties than the analogous zinc and vanadyl complexes regarding lethality, reduction of motor activity, and oviposition.
authors.affiliation: Núcleo de Pesquisa em Doenças Negligenciadas, Universidade Guarulhos, Guarulhos, SP, Brazil josuem@usp.br moraesnpdn@gmail.com.
authors.forename: Josué
authors.initials: J
authors.lastname: de Moraes
authors.affiliation: Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Bruno S
authors.initials: BS
authors.lastname: Dario
authors.affiliation: Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Ricardo A A
authors.initials: RA
authors.lastname: Couto
authors.affiliation: Núcleo de Enteroparasitas, Instituto Adolfo Lutz, São Paulo, SP, Brazil.
authors.forename: Pedro L S
authors.initials: PL
authors.lastname: Pinto
authors.affiliation: Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Ana M
authors.initials: AM
authors.lastname: da Costa Ferreira
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry* / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry; D012550:Schistosoma mansoni / Q000187:drug effects*; D015032:Zinc / Q000737:chemistry
chemical_list: D000871:Anthelmintics; D056831:Coordination Complexes; D003300:Copper; D015032:Zinc