title: Fat may affect magnetic resonance signal intensity and brain tissue volumes.
abstract: Obesity/overweight is reported to affect MR-measured brain tissue volume and white matter (WM) signal intensity. This study investigated possible effects of fat on these measures, using pig fat on three participants at a 4T magnet. Grey matter volumes in the presence of fat were lower than baseline measures. Total WM volumes in the presence of fat were higher than baseline measures. WM hypo-intensities on T1-weighted images were higher in the presence of fat than baseline measures. Therefore physical effects of head fat of obese/overweight individual may at least, partly contribute to the association of obesity/overweight with MR structural measures.
authors.affiliation: Department of Biomedical Engineering, Faculty of Health and Allied Sciences, Koforidua Polytechnic, Ghana. Electronic address: baarenaba@hotmail.com.
authors.forename: Anderson
authors.initials: A
authors.lastname: Mon
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Christoph
authors.initials: C
authors.lastname: Abé
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center San Francisco, CA, USA.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Durazzo
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center San Francisco, CA, USA.
authors.forename: Dieter J
authors.initials: DJ
authors.lastname: Meyerhoff
mesh_terms: D000273:Adipose Tissue; D050154:Adiposity; D000328:Adult; D066128:Gray Matter; D006257:Head; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000473:pathology; D009929:Organ Size; D066127:White Matter
keywords: Fat; Grey matter; Magnetic resonance signal hypo-intensity; Obesity; White matter