title: Catha Edulis (Khat) Chewing Decreases Serum Levels of Iron, Ferritin and Vitamin B12 and Increases Folic Acid.
abstract: BACKGROUND
  Catha edulis (Khat) is customarily chewed to attain a state of stimulation and reduce physical fatigue. In view of the reported common adverse effects of Khat, the aim of this study was to evaluate the levels of iron, ferritin, folic acid, vitamin B(12) and body mass index (BMI) as nutritive indicators in Yemeni Khat chewers.
  
  
  METHODS
  This study was a prospective cohort study, carried out on 90 male workers aged 19 - 23 years old; 45 were healthy non-Khat chewers serving as control group and 45 were regular Khat chewers. Serum iron, ferritin, folic acid, vitamin B(12) and body mass index were measured at baseline and after a year of follow up.
  
  
  RESULTS
  Serum iron and BMI were significantly (p < 0.01) lower at baseline in Khat chewers by 9 % and 6 %, respectively; whereas ferritin, folic acid and vitamin B(12) were non-significantly different from non-Khat chewers. In the follow-up one year later, serum iron, ferritin, vitamin B(12) and BMI were significantly (p < 0.001) lower in Khat chewers by 19.0, 31.4, 20.6 and 10.7 %; whereas folic acid was significantly (p = 0.007) higher by 26.7 %. Comparison within groups showed serum iron, ferritin, and BMI to be significantly (p < 0.01) decreased after one year in the Khat chewers with respect to its baseline; whereas folic acid significantly (p < 0.001) increased.
  
  
  CONCLUSIONS
  This study shows Khat chewers to be more susceptible to malnutrition, which should be considered by the general population and the public health authorities.
authors.affiliation: 1 Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana'a, Yemen.
authors.forename: Waled
authors.initials: W
authors.lastname: Al-Dubai
authors.forename: Jameel
authors.initials: J
authors.lastname: Al-Ghazaly
authors.forename: Molham
authors.initials: M
authors.lastname: Al-Habori
authors.forename: Riyadh
authors.initials: R
authors.lastname: Saif-Ali
authors.forename: Ahmed
authors.initials: A
authors.lastname: Mohammed
mesh_terms: D029754:Catha / Q000009:adverse effects*; D015331:Cohort Studies; D005293:Ferritins / Q000097:blood*; D005492:Folic Acid / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D014805:Vitamin B 12 / Q000097:blood*; D055815:Young Adult
chemical_list: D005293:Ferritins; D005492:Folic Acid; D007501:Iron; D014805:Vitamin B 12
keywords: Catha edulis; Khat; ferritin; folic acid; iron; vitamin B12