title: Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats.
abstract: Transforming growth factor-β 1 (TGFβ1) has a diverse role in astrogliosis and neuronal survival, but the underlying mechanism remains to be elucidated, especially in traumatic brain injury (TBI). Here, we show that the expression of TGFβ1 was increased in the pericontusional region, accompanied with astrogliosis and neuronal loss in TBI rats. Moreover, TGFβ1 knockdown not only reduced the number of neurons and inhibited astrogliosis but also resulted in a significant neurological dysfunction in rats with TBI. Subsequently, Smad3, a key downstream signal of TGFβ1, was involved in pericontusional region after TBI. These findings therefore indicate that TGFβ1 is involved in neuroprotection and astrogliosis, via activation of down stream Smad3 signal in the brain after injury.
authors.affiliation: Department of Neurosurgery, Shanghai Jiao Tong University Affiliated 6th People's Hospital, Shanghai, 200233, China.
authors.forename: Xu-Yang
authors.initials: XY
authors.lastname: Wang
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Ba
authors.forename: Liu-Lin
authors.initials: LL
authors.lastname: Xiong
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Zou
authors.forename: Ye-Chun
authors.initials: YC
authors.lastname: Zhu
authors.forename: Xin-Fu
authors.initials: XF
authors.lastname: Zhou
authors.forename: Ting-Hua
authors.initials: TH
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Heng-Li
authors.initials: HL
authors.lastname: Tian
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Li
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D051900:Smad3 Protein / Q000096:biosynthesis*; D053773:Transforming Growth Factor beta1 / Q000502:physiology*
chemical_list: D051900:Smad3 Protein; C497787:Smad3 protein, rat; D053773:Transforming Growth Factor beta1