title: Pathologic sequelae of allosensitization in liver transplantation.
abstract: The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: mzimmerman@mcw.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Zimmerman
authors.affiliation: Histocompatibility and Immunogenetics, BloodCenter of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Schiller
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Joohyun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Alicia
authors.initials: A
authors.lastname: Martin
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Motaz
authors.initials: M
authors.lastname: Selim
authors.affiliation: Division of Transplant Surgery, Department of Surgery, University of Colorado, Denver, Colorado.
authors.forename: Trevor L
authors.initials: TL
authors.lastname: Nydam
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: David
authors.initials: D
authors.lastname: Cronin
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Johnny C
authors.initials: JC
authors.lastname: Hong
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008099:Liver / Q000276:immunology / Q000473:pathology*; D016031:Liver Transplantation
chemical_list: D000017:ABO Blood-Group System; D007518:Isoantibodies
keywords: Anastomotic stricture; Antibody-mediated rejection; Biliary complication; Donor-specific antibody; Graft fibrosis; Orthotopic liver transplant