title: Q192R and L55M Polymorphisms of Paraoxonase 1 Gene in Chronic Myelogenous Leukemia and Chronic Lymphocytic Leukemia.
abstract: OBJECTIVE
  The aim of the present study was to investigate the association between Paraoxonase 1 (PON1) gene polymorphisms Q192R, and L55M in patients with Chronic Myelogenous Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL) patients.
  
  
  METHODS
  We analyzed samples from 60 patients with CML, 60 with CLL and 84 healthy controls. Polymerase Chain Reaction (PCR)--Restriction Fragment Length Polymorphism (RLFP) was performed and samples were run in agarose gel.
  
  
  RESULTS
  We found statistically significant results showing an increase in both the RR genotype (p=0.044) and the R allele (p=0.011) for PON1 Q192R, and an increase in the MM genotype (p=0.007) and a decrease in the LL genotype (p=0.004) and R allele (p=0.001) in PON1 L55M in patients with CLL.
  
  
  CONCLUSIONS
  We concluded that both the Q192R gene polymorphism with an increase in the genotype R allele, and the M/L55 with an increase in the MM genotype play a role in CLL susceptibility, and a decrease in the LL genotype can act against disease in the Turkish population.
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkey tomatir@pau.edu.tr aysegaye@hotmail.com.
authors.forename: Ayşe Gaye
authors.initials: AG
authors.lastname: Tomatir
authors.affiliation: Department of Medical Biology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Sacide
authors.initials: S
authors.lastname: Pehlivan
authors.affiliation: Department of Hematology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Handan Haydaroğlu
authors.initials: HH
authors.lastname: Sahin
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Sibel Oguzkan
authors.initials: SO
authors.lastname: Balci
authors.affiliation: Department of Hematology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Selin
authors.initials: S
authors.lastname: Budeyri
authors.affiliation: Department of Hematology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Pehlivan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: L55M polymorphism; PCR-RFLP; Paraoxonase-1 (PON1); Q192R polymorphism; chronic lymphocytic leukemia (CLL); chronic myeoloid leukemia (CML)