title: Clinical Pharmacology of Alpha-1 Blockers Improving Drug-profile through Novel Formulations.
abstract: Clinical pharmacology is an essential consideration in chronic therapies, and may play a significant role in modifying the pharmacological characteristics of drug formulations. Improvement in drug formulations may ensure their safe and effective use over a period of time. This has been particularly observed with α-1 adrenergic blockers in hypertension management. Advancements in formulations like prazosin GITS, have resulted in improvement in tolerability profile and smoother, more effective blood pressure control, which reasonably translate into improvement in patient compliance and better clinical outcomes.
authors.forename: Rajan P
authors.initials: RP
authors.lastname: Nerurkar
authors.forename: Jignesh K
authors.initials: JK
authors.lastname: Ved
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*
chemical_list: D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations