title: Protein cold adaptation: Role of physico-chemical parameters in adaptation of proteins to low temperatures.
abstract: During years 2007 and 2008, we published three papers (Jahandideh, 2007a, JTB, 246, 159-166; Jahandideh, 2007b, JTB, 248, 721-726; Jahandideh, 2008, JTB, 255, 113-118) investigating sequence and structural parameters in adaptation of proteins to low temperatures. Our studies revealed important features in cold-adaptation of proteins. Here, we calculate values of a new set of physico-chemical parameters and perform a comparative systematic analysis on a more comprehensive database of psychrophilic-mesophilic homologous protein pairs. Our obtained results confirm that psychrophilicity rules are not merely the inverse rules of thermostability; for instance, although contact order is reported as a key feature in thermostability, our results have shown no significant difference between contact orders of psychrophilic proteins compared to mesophilic proteins. We are optimistic that these findings would help future efforts to propose a strategy for designing cold-adapted proteins.
authors.affiliation: Department of Medicinal Biotechnology, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Soheila
authors.initials: S
authors.lastname: Shokrollahzade
authors.affiliation: Department of Computer Science, Shahid Beheshti University, G.C., Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sharifi
authors.affiliation: Young Researchers and Elite club, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Vaseghi
authors.affiliation: Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.
authors.forename: Maryam
authors.initials: M
authors.lastname: Faridounnia
authors.affiliation: Program on Bioinformatics and Systems Biology, Sanfore Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92307, United States. Electronic address: sjahandideh@burnham.org.
authors.forename: Samad
authors.initials: S
authors.lastname: Jahandideh
mesh_terms: D000064:Acclimatization / Q000502:physiology; D000222:Adaptation, Physiological; D055598:Chemical Phenomena; D003080:Cold Temperature; D030562:Databases, Protein; D006860:Hydrogen Bonding; D008970:Molecular Weight; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: Packing density; Structural features; Surface accessibility; Systematics analysis; Thermostability