title: Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine.
abstract: Mycoplasma pneumonia of swine (MPS) lung lesions and immunogenic properties were compared between a Landrace line that was genetically selected for reduced incidence of pulmonary MPS lesions, and a non-selected Landrace line. The MPS-selected Landrace line showed significantly lower degrees of pulmonary MPS lesions compared with the non-selected Landrace line. When changes in immunity before and after vaccination were compared, the percentage of B cells in the peripheral blood of the MPS-selected Landrace line was significantly lower than that of the non-selected line. Furthermore, the concentration of growth hormone and the mitogen activity of peripheral blood mononuclear cells in the MPS-selected Landrace line showed significantly (P < 0.05) lower increases after vaccination than the non-selected line. Conversely, the concentration of peripheral blood interferon (IFN)-γ and salivary immunoglobulin A (IgA) after Mycoplasma hyopneumoniae vaccination was significantly higher in the MPS-selected Landrace line than in the non-selected line. Gene expression of toll-like receptor (TLR)2 and TLR4 was significantly higher in the MPS-selected Landrace line in immune tissues, with the exception of the hilar lymph nodes. The present results suggest that peripheral blood IFN-γ, salivary IgA TLR2, and TLR4 are important immunological factors influencing the development of MPS lesions.
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Liushiqi
authors.initials: L
authors.lastname: Borjigin
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shimazu
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Katayama
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Meihua
authors.initials: M
authors.lastname: Li
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Satoh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Kitazawa
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Sang-gun
authors.initials: SG
authors.lastname: Roh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Aso
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Katoh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Food, Agriculture and Environment, Miyagi University, Sendai, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Suda
authors.affiliation: Miyagi Prefecture Animal Industry Experiment Station, Miyagi, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sakuma
authors.affiliation: Miyagi Prefecture Animal Industry Experiment Station, Miyagi, Japan.
authors.forename: Mituru
authors.initials: M
authors.lastname: Nakajo
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D005260:Female; D015870:Gene Expression; D007070:Immunoglobulin A / Q000276:immunology; D007371:Interferon-gamma / Q000097:blood; D008297:Male; D045705:Mycoplasma hyopneumoniae / Q000276:immunology*; D045729:Pneumonia of Swine, Mycoplasmal / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D012641:Selection, Genetic; D013552:Swine / Q000235:genetics* / Q000276:immunology*; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism
chemical_list: D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D007371:Interferon-gamma
keywords: disease resistance; immunogenic properties; mycoplasma pneumonia lesions; pig