title: The relation of structural integrity and task-related functional connectivity in the aging brain.
abstract: The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.
authors.affiliation: Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia; ARC Centre of Excellence in Cognition and Its Disorders, Department of Cognitive Science, Macquarie University, Sydney, New South Wales, Australia. Electronic address: hana.burianova@cai.uq.edu.au.
authors.forename: Hana
authors.initials: H
authors.lastname: Burianová
authors.affiliation: Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia; ARC Science of Learning Research Centre, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Lars
authors.initials: L
authors.lastname: Marstaller
authors.affiliation: Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Jeiran
authors.initials: J
authors.lastname: Choupan
authors.affiliation: Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Farshid
authors.initials: F
authors.lastname: Sepehrband
authors.affiliation: The School of Psychology, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Maryam
authors.initials: M
authors.lastname: Ziaei
authors.affiliation: Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Reutens
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology* / Q000502:physiology / Q000523:psychology*; D001921:Brain / Q000473:pathology* / Q000502:physiology* / Q000503:physiopathology; D003071:Cognition / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology* / Q000503:physiopathology; D059906:Neuroimaging; D009929:Organ Size; D055815:Young Adult
keywords: Age-related compensation; Functional connectivity; Gray matter; Structural integrity; White matter