title: Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease.
abstract: Fruit flies (Drosophila melanogaster) have been widely used to study the cellular and molecular basis of human neurodegenerative disease. The biological similarities between the human and the fly have been explored successfully to further investigate the pathological basis of Alzheimer's disease (AD). Here, we discuss transgenic Drosophila models systems and the methodologies that have been employed in the study of AD.
authors.affiliation: Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
authors.forename: Jung Yeon
authors.initials: JY
authors.lastname: Lim
authors.forename: Stanislav
authors.initials: S
authors.lastname: Ott
authors.forename: Damian C
authors.initials: DC
authors.lastname: Crowther
mesh_terms: D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005260:Female; D006824:Hybridization, Genetic; D015151:Immunoblotting; D007150:Immunohistochemistry; D008136:Longevity; D008297:Male; D009043:Motor Activity; D012995:Solubility
chemical_list: D016229:Amyloid beta-Peptides