title: Localized radiation necrosis model in mouse brain using proton ion beams.
abstract: Brain radiation necrosis is the most serious late adverse event that occurs after 6 months following radiation therapy. Effective treatment for this irreversible brain necrosis has not been established yet. This study tries to establish brain radiation necrosis mouse model using proton or helium beam. The right cerebral hemispheres of C57BL/6J mouse brains were irradiated at doses of 40, 50, 60 Gy with charged particles. In 60 Gy group, brain necrosis that recapitulates human disease was detected after 8 months.
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan. Electronic address: nkondo@rri.kyoto-u.ac.jp.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan; The Wakasa Wan Energy Research Center, 64-52-1, Nagatani, Tsuruga, Fukui 914-0315, Japan.
authors.forename: Takushi
authors.initials: T
authors.lastname: Takata
authors.affiliation: Nagasaki International University, 2825-7, Housetenbosu, Sasebo, Nagasaki 859- 3298, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Takai
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakagawa
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: The Wakasa Wan Energy Research Center, 64-52-1, Nagatani, Tsuruga, Fukui 914-0315, Japan.
authors.forename: Kyo
authors.initials: K
authors.lastname: Kume
authors.affiliation: Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
authors.forename: Taichiro
authors.initials: T
authors.lastname: Toho
authors.affiliation: Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Miyatake
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Masunaga
authors.affiliation: Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
mesh_terms: D000818:Animals; D001921:Brain / Q000528:radiation effects*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D011522:Protons; D011833:Radiation Injuries, Experimental / Q000473:pathology*
chemical_list: D011522:Protons
keywords: Brain radiation necrosis model; Histology; MRI; Proton beams