title: Oritavancin Pharmacokinetics and Bone Penetration in Rabbits.
abstract: The pharmacokinetics and bone concentrations of oritavancin were investigated after a single intravenous dose was administered to rabbits. The pharmacokinetic profile of oritavancin in rabbits showed that it is rapidly distributed to bone tissues, with concentrations remaining stable for up to 168 h, the last measured time point. Based on these findings, further evaluation of oritavancin for the treatment of infections in bone tissues is warranted.
authors.affiliation: The Medicines Company, St. Laurent, Quebec, Canada dario.lehoux@themedco.com.
authors.forename: Dario
authors.identifier: http://orcid.org/0000-0003-3729-2871
authors.initials: D
authors.lastname: Lehoux
authors.affiliation: The Medicines Company, St. Laurent, Quebec, Canada.
authors.forename: Valerie
authors.initials: V
authors.lastname: Ostiguy
authors.affiliation: The Medicines Company, St. Laurent, Quebec, Canada.
authors.forename: Cordelia
authors.initials: C
authors.lastname: Cadieux
authors.affiliation: The Medicines Company, St. Laurent, Quebec, Canada.
authors.forename: Mireille
authors.initials: M
authors.lastname: Malouin
authors.affiliation: The Medicines Company, St. Laurent, Quebec, Canada.
authors.forename: Odette
authors.initials: O
authors.lastname: Belanger
authors.affiliation: The Medicines Company, St. Laurent, Quebec, Canada.
authors.forename: Adel Rafai
authors.initials: AR
authors.lastname: Far
authors.affiliation: The Medicines Company, St. Laurent, Quebec, Canada.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Parr
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D001692:Biological Transport; D001853:Bone Marrow / Q000737:chemistry / Q000378:metabolism*; D006020:Glycopeptides / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D000077427:Lipoglycopeptides; D008297:Male; D011817:Rabbits; D013977:Tibia / Q000737:chemistry / Q000378:metabolism*; D014640:Vancomycin / Q000031:analogs & derivatives
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D000077427:Lipoglycopeptides; C100708:oritavancin; D014640:Vancomycin