title: Regulation of Dendritic Cell Function in Inflammation.
abstract: Dendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system. During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens. Under pathological skin conditions, inflammatory cytokines, secreted by surrounding keratinocytes, dermal fibroblasts, and immune cells, influence the activation and maturation of different DC populations including Langerhans cells (LC) and dermal DC. In this review we address critical differences in human DC subtypes during inflammatory settings compared to steady state. We also highlight the functional characteristics of human DC subsets in inflammatory skin environments and skin diseases including psoriasis and atopic dermatitis. Understanding the complex immunoregulatory role of distinct DC subsets in inflamed human skin will be a key element in developing novel strategies in anti-inflammatory therapy.
authors.affiliation: Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, 14195 Berlin, Germany.
authors.forename: André
authors.initials: A
authors.lastname: Said
authors.affiliation: Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, 14195 Berlin, Germany.
authors.forename: Günther
authors.initials: G
authors.lastname: Weindl
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D003872:Dermatitis / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators