title: Clinicopathological significance of KAI1 expression and epithelial-mesenchymal transition in non-small cell lung cancer.
abstract: BACKGROUND
  KAI1 and epithelial-mesenchymal transition (EMT) is related to both angiogenesis and lymphangiogenesis and is an important target in new cancer treatment strategies. We aimed to investigate the KAI1 and marker of EMT expression and correlation with lymph node metastasis (LNM) and explore their prognostic impact in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Tumor tissue specimens from 312 resected patients with stage I-IIIA NSCLC were obtained. Immunohistochemistry was used to assess the expression of the molecular markers KAI1, E-cadherin (E-cad), vimentin, CD34, and D2-40.
  
  
  RESULTS
  There were 153 N0 and 159 N+ patients. Tumor cell expression of KAI1and the marker of EMT, lymphatic vessel density (LVD), and microvessel density (MVD) were related to LNM. In multivariate analyses, the ages of patients, high tumor cell KAI1 expression, EMT, and the scores of MVD were independent factor of prognosis.
  
  
  CONCLUSIONS
  Tumor cell KAI1 expression, EMT, LVD, and MVD correlate with LNM. Thus, the detection of KAI1, expression of markers of EMT, and the scores of MVD may be used as a potential indicator of NSCLC prognosis.
authors.affiliation: Department of Pathology, the First Hospital Affiliated of Bengbu Medical College, Bengbu Medical College, No. 287 Changhuai Ave, Longzihu, Bengbu, Anhui Province, 233003, China. zhou_lei03@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Pathology, the First Hospital Affiliated of Bengbu Medical College, Bengbu Medical College, No. 287 Changhuai Ave, Longzihu, Bengbu, Anhui Province, 233003, China. yulan790210@163.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Pathology, the First Hospital Affiliated of Bengbu Medical College, Bengbu Medical College, No. 287 Changhuai Ave, Longzihu, Bengbu, Anhui Province, 233003, China. 573448542@qq.com.
authors.forename: Shiwu
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Pathology, the First Hospital Affiliated of Bengbu Medical College, Bengbu Medical College, No. 287 Changhuai Ave, Longzihu, Bengbu, Anhui Province, 233003, China. fzzapple1976@163.com.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Pathology, the First Hospital Affiliated of Bengbu Medical College, Bengbu Medical College, No. 287 Changhuai Ave, Longzihu, Bengbu, Anhui Province, 233003, China. 1043910994@qq.com.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Pathology, the First Hospital Affiliated of Bengbu Medical College, Bengbu Medical College, No. 287 Changhuai Ave, Longzihu, Bengbu, Anhui Province, 233003, China. 1051807365@qq.com.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Gong
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism; D018287:Carcinoma, Large Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D051861:Kangai-1 Protein / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D042583:Lymphangiogenesis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C497688:CD82 protein, human; D015820:Cadherins; D051861:Kangai-1 Protein; D014746:Vimentin