title: Erythropoietin and Neonatal Neuroprotection.
abstract: Certain groups of neonates are at high risk of developing long-term neurodevelopmental impairment and might be considered candidates for neuroprotective interventions. This article explores some of these high-risk groups, relevant mechanisms of brain injury, and specific mechanisms of cellular injury and death. The potential of erythropoietin (Epo) to act as a neuroprotective agent for neonatal brain injury is discussed. Clinical trials of Epo neuroprotection in preterm and term infants are updated.
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Washington, 1959 Northeast Pacific Street, Box 356320, Seattle, WA 98195-6320, USA. Electronic address: sjuul@uw.edu.
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Juul
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Washington, 1959 Northeast Pacific Street, Box 356320, Seattle, WA 98195-6320, USA.
authors.forename: Gillian C
authors.initials: GC
authors.lastname: Pet
mesh_terms: D004921:Erythropoietin / Q000627:therapeutic use*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000517:prevention & control*; D007231:Infant, Newborn; D000066829:Neuroprotection
chemical_list: D004921:Erythropoietin
keywords: Apoptosis; Autophagy; Brain injury; Erythropoietin; Extreme prematurity; Hypoxic ischemic encephalopathy; Necrosis