title: Changes in Thickness of Mucosa Adjacent to Implants Using Tissue Matrix Allograft: A Clinical and Histologic Evaluation.
abstract: OBJECTIVE
  To clinically and histologically evaluate the soft tissue thickening seen on acellular human dermis grafting at implant placement, taking into consideration the biotype.
  
  
  METHODS
  Mucosal thickness was measured before and 4 months after implant placement, when the thickness of the epithelium and corium and the inflammation were histologically evaluated with a skin biopsy. Results were analyzed using the Mann-Whitney U test and linear regression analysis.
  
  
  RESULTS
  In a total of 47 implant sites (22 uncovered and 25 covered by the allograft matrix), the grafted sites showed a significantly greater increase in thickness compared with the control sites. Histology was unable to show differences between groups. Nevertheless, using an individual variation index involving the histologic and initial clinical thickness, the increase in thickness of grafted sites was statistically significant (P = .017) compared with the decrease in control sites. Furthermore, the greatest thickness increase was recorded in sites with thin biotype, whereas a decrement was found in control sites. The inflammation index was similar in both groups.
  
  
  CONCLUSIONS
  This study demonstrated the effectiveness of evaluating the increase in mucosal thickness with acellular human dermis grafting, particularly in subjects with thin biotype.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Farina
authors.forename: Davide
authors.initials: D
authors.lastname: Zaffe
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000368:Aged; D064591:Allografts / Q000637:transplantation*; D001706:Biopsy / Q000379:methods; D015921:Dental Implants; D020405:Dermis / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology*; D005893:Gingivoplasty / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D016038:Skin Transplantation / Q000379:methods*; D013524:Surgical Flaps / Q000601:surgery
chemical_list: D015921:Dental Implants; D008567:Membranes, Artificial