title: Inflammatory bowel disease of the lung: The role of infliximab?
abstract: Pulmonary extra-intestinal manifestations (EIM) of inflammatory bowel disease are well described with a variable incidence. We present a case of Crohn's disease with pulmonary EIM including chronic bronchitis with non-resolving bilateral cavitary pulmonary nodules and mediastinal lymphadenopathy successfully treated with infliximab. Additionally, we present a case summary from a literature review on pulmonary EIM successfully treated with infliximab. Current treatment recommendations include an inhaled and/or systemic corticosteroid regimen which is largely based on case reports and expert opinion. We offer infliximab as an adjunctive therapy or alternative to corticosteroids for treatment of inflammatory bowel disease related pulmonary EIM.
authors.affiliation: Department of Internal Medicine, Baylor Scott & White Health and Texas A&M HSC College of Medicine, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Hayek
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, Baylor Scott & White Health, USA.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Pfanner
authors.affiliation: Department of Internal Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, Baylor Scott & White Health, USA.
authors.forename: Heath D
authors.initials: HD
authors.lastname: White
keywords: EIM, extra-intestinal manifestations; IBD, inflammatory bowel disease; Inflammatory bowel disease; Infliximab; Pulmonary extraintestinal manifestations; TNF, tumor necrosis factor