title: Mesenchymal Stromal Cell Therapy in Ischemia/Reperfusion Injury.
abstract: Ischemia/reperfusion injury (IRI) represents a worldwide public health issue of increasing incidence. IRI may virtually affect all organs and tissues and is associated with significant morbidity and mortality. Particularly, the duration of blood supply deprivation has been recognized as a critical factor in stroke, hemorrhagic shock, or myocardial infarction, as well as in solid organ transplantation (SOT). Pathophysiologically, IRI causes multiple cellular and tissular metabolic and architectural changes. Furthermore, the reperfusion of ischemic tissues induces both local and systemic inflammation. In the particular field of SOT, IRI is an unavoidable event, which conditions both short- and long-term outcomes of graft function and survival. Clinically, the treatment of patients with IRI mostly relies on supportive maneuvers since no specific target-oriented therapy has been validated thus far. In the present review, we summarize the current literature on mesenchymal stromal cells (MSC) and their potential use as cell therapy in IRI. MSC have demonstrated immunomodulatory, anti-inflammatory, and tissue repair properties in rodent studies and in preliminary clinical trials, which may open novel avenues in the management of IRI and SOT.
authors.affiliation: Division of Nephrology and Transplantation, University of Liège CHU (ULg CHU), 4000 Liège, Belgium ; Laboratory of Cardiovascular Sciences, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), University of Liège, 4000 Liège, Belgium.
authors.forename: Pascal
authors.initials: P
authors.lastname: Rowart
authors.affiliation: Division of Nephrology and Transplantation, University of Liège CHU (ULg CHU), 4000 Liège, Belgium ; Laboratory of Cardiovascular Sciences, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), University of Liège, 4000 Liège, Belgium.
authors.forename: Pauline
authors.initials: P
authors.lastname: Erpicum
authors.affiliation: Laboratory of Cardiovascular Sciences, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), University of Liège, 4000 Liège, Belgium ; Division of Abdominal Surgery and Transplantation, University of Liège CHU (ULg CHU), 4000 Liège, Belgium.
authors.forename: Olivier
authors.initials: O
authors.lastname: Detry
authors.affiliation: Division of Nephrology and Transplantation, University of Liège CHU (ULg CHU), 4000 Liège, Belgium.
authors.forename: Laurent
authors.initials: L
authors.lastname: Weekers
authors.affiliation: Laboratory of Hematology, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), University of Liège, 4000 Liège, Belgium.
authors.forename: Céline
authors.initials: C
authors.lastname: Grégoire
authors.affiliation: Laboratory of Cell and Gene Therapy, University of Liège CHU (ULg CHU), 4000 Liège, Belgium.
authors.forename: Chantal
authors.initials: C
authors.lastname: Lechanteur
authors.affiliation: Laboratory of Hematology, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), University of Liège, 4000 Liège, Belgium ; Laboratory of Cell and Gene Therapy, University of Liège CHU (ULg CHU), 4000 Liège, Belgium.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Briquet
authors.affiliation: Laboratory of Hematology, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), University of Liège, 4000 Liège, Belgium ; Laboratory of Cell and Gene Therapy, University of Liège CHU (ULg CHU), 4000 Liège, Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: Beguin
authors.affiliation: Division of Nephrology and Transplantation, University of Liège CHU (ULg CHU), 4000 Liège, Belgium ; Laboratory of Cardiovascular Sciences, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), University of Liège, 4000 Liège, Belgium.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
authors.affiliation: Division of Nephrology and Transplantation, University of Liège CHU (ULg CHU), 4000 Liège, Belgium ; Laboratory of Cardiovascular Sciences, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), University of Liège, 4000 Liège, Belgium.
authors.forename: François
authors.initials: F
authors.lastname: Jouret
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D002545:Brain Ischemia / Q000628:therapy; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000628:therapy; D008107:Liver Diseases / Q000209:etiology / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000628:therapy; D010641:Phenotype; D015427:Reperfusion Injury / Q000209:etiology / Q000628:therapy*
chemical_list: D000954:Antigens, Surface