title: Combating Superbug Without Antibiotic on a Postamputation Wound in a Patient with Diabetic Foot.
abstract: Diabetic foot is a kind of limb- and life-threatening complication that is difficult to treat with conventional therapy, especially when accompanied with peripheral arterial insufficiency and severe infection. We present a diabetic patient with a postamputation wound infected by multidrug-resistant Acinetobacter baumannii/haemolyticus, which was resistant to almost all antibiotics. As the clinical response to antimicrobial therapy was poor, antibiotic was discontinued. Autologous platelet-rich gel with anticoagulation, negative pressure wound therapy, and improvement of microcirculation were used successfully to eradicate infection of the superbug and achieve final wound closure.
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Shuyao
authors.initials: S
authors.lastname: Sun
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Cen
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xiaoju
authors.initials: X
authors.lastname: Lv
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Wen
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Wusheng
authors.initials: W
authors.lastname: Lu
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Jichun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China ranxingwu@163.com.
authors.forename: Xingwu
authors.initials: X
authors.lastname: Ran
mesh_terms: D000369:Aged, 80 and over; D000671:Amputation, Surgical; D000900:Anti-Bacterial Agents; D003131:Combined Modality Therapy; D017719:Diabetic Foot / Q000601:surgery*; D006801:Humans; D008297:Male; D013530:Surgical Wound Infection / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents
keywords: autologous platelet-rich gel; diabetic foot; multidrug-resistant bacterial infection; negative pressure wound therapy