title: Content validity of Patient-Reported Outcomes Measurement Information System (PROMIS) items in the context of HIV clinical care.
abstract: OBJECTIVE
  To assess content validity and patient and provider prioritization of Patient-Reported Outcomes Measurement Information System (PROMIS) depression, anxiety, fatigue, and alcohol use items in the context of clinical care for people living with HIV (PLWH), and to develop and assess new items as needed.
  
  
  METHODS
  We conducted concept elicitation interviews (n = 161), item pool matching, prioritization focus groups (n = 227 participants), and cognitive interviews (n = 48) with English-speaking (~75 %) and Spanish-speaking (~25 %) PLWH from clinical sites in Seattle, San Diego, Birmingham, and Boston. For each domain we also conducted item review and prioritization with two HIV provider panels of 3-8 members each.
  
  
  RESULTS
  Among items most highly prioritized by PLWH and providers were those that included information regarding personal impacts of the concept being assessed, in addition to severity level. Items that addressed impact were considered most actionable for clinical care. We developed additional items addressing this. For depression we developed items related to suicide and other forms of self-harm, and for all domains we developed items addressing impacts PLWH and/or providers indicated were particularly relevant to clinical care. Across the 4 domains, 16 new items were retained for further psychometric testing.
  
  
  CONCLUSIONS
  PLWH and providers had priorities for what they believed providers should know to provide optimal care for PLWH. Incorporation of these priorities into clinical assessments used in clinical care of PLWH may facilitate patient-centered care.
authors.affiliation: Department of Health Services, School of Public Health, University of Washington, 1208 NE 43rd St., Seattle, WA, 98195, USA. toddce@uw.edu.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Edwards
authors.affiliation: Harborview Madison Clinic, School of Medicine, University of Washington, 325 9th Avenue, Seattle, WA, 98104, USA.
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Fredericksen
authors.affiliation: Harborview Madison Clinic, School of Medicine, University of Washington, 325 9th Avenue, Seattle, WA, 98104, USA.
authors.forename: Heidi M
authors.initials: HM
authors.lastname: Crane
authors.affiliation: Harborview Madison Clinic, School of Medicine, University of Washington, 325 9th Avenue, Seattle, WA, 98104, USA.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Crane
authors.affiliation: Harborview Madison Clinic, School of Medicine, University of Washington, 325 9th Avenue, Seattle, WA, 98104, USA.
authors.forename: Mari M
authors.initials: MM
authors.lastname: Kitahata
authors.affiliation: Owen Clinic, University of California - San Diego, 4168 Front St, San Diego, CA, 92103, USA.
authors.forename: William C
authors.initials: WC
authors.lastname: Mathews
authors.affiliation: The Fenway Institute, School of Public Health, Harvard University, 1340 Boylston Street, Boston, MA, 02215, USA.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
authors.affiliation: Department of Health Services, School of Public Health, University of Washington, 1208 NE 43rd St., Seattle, WA, 98195, USA.
authors.forename: Leo S
authors.initials: LS
authors.lastname: Morales
authors.affiliation: 1917 Clinic, University of Alabama - Birmingham, 908 20th Street S, Suite 250, Birmingham, AL, 35205, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mugavero
authors.affiliation: Department of Health Services, School of Public Health, University of Washington, 1208 NE 43rd St., Seattle, WA, 98195, USA.
authors.forename: Rosa
authors.initials: R
authors.lastname: Solorio
authors.affiliation: Georgia Regents University, 1459 Laney Walker Blvd, Augusta, GA, 30901, USA.
authors.forename: Frances M
authors.initials: FM
authors.lastname: Yang
authors.affiliation: Department of Health Services, School of Public Health, University of Washington, 1208 NE 43rd St., Seattle, WA, 98195, USA.
authors.forename: Donald L
authors.initials: DL
authors.lastname: Patrick
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D018802:Patient-Centered Care / Q000379:methods*; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D055815:Young Adult
keywords: Clinical practice; HIV; PROMIS; Patient-centered outcomes