title: Perspectives of Genome-Editing Technologies for HIV Therapy.
abstract: BACKGROUND
  Current HIV antiretroviral therapies potently suppress virus replication and prevent patients from progressing to AIDS but are unable to completely eliminate HIV due to the existence of dormant viral reservoirs which threaten to reemerge at anytime. Recently, genome-editing technologies that can recognize specific DNA sequences, including viral DNA, are being touted as promising tools for curing HIV, owing to their specificity, ease of use, and ability to be custom designed.
  
  
  CONCLUSIONS
  Here, we introduce several novel strategies aimed at eradicating HIV proviruses with state-of-the-art genome-editing technologies and discuss perspectives of these approaches for curing HIV.
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara- cho, Sakyo-ku, Kyoto 606-8507, Japan. hebina@virus.kyoto-u.ac.jp.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ebina
authors.forename: Peter
authors.initials: P
authors.lastname: Gee
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Koyanagi
mesh_terms: D004279:DNA, Viral / Q000235:genetics; D060740:Disease Eradication / Q000379:methods; D015316:Genetic Therapy / Q000379:methods*; D015658:HIV Infections / Q000628:therapy*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D011533:Proviruses / Q000235:genetics*; D017735:Virus Latency / Q000235:genetics
chemical_list: D004279:DNA, Viral