title: Impact of Interstitial Changes on Radiation Pneumonitis After Stereotactic Body Radiation Therapy for Lung Cancer.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the impact of interstitial changes (IC) on radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for lung cancer.
  
  
  METHODS
  We analyzed 260 consecutive patients with primary lung cancer treated with SBRT. According to the presence or absence of IC on the pre-treatment computed tomography, patients were divided into two groups: an IC group (n=18) and a non-IC group (n=242).
  
  
  RESULTS
  RP of grade 2 or more was observed in 9 (50.0%) and 14 (6.7%) patients in the IC and non-IC group, respectively. All three patients with grade 5 RP were in the IC group. As indicated by multivariate analysis, the presence of IC was the only significant predictive factor of RP of grade 2 or more.
  
  
  CONCLUSIONS
  The presence of IC was a significant indicator of grade 2 or more RP after SBRT for patients with lung cancer.
authors.affiliation: Department of Comprehensive Clinical Oncology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan yoshitake@radiol.med.kyushu-u.ac.jp.
authors.forename: Tadamasa
authors.initials: T
authors.lastname: Yoshitake
authors.affiliation: Kyushu International Heavy Ion Beam Therapy Center, Tosu-shi, Saga, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Shioyama
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Asai
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Tomonari
authors.initials: T
authors.lastname: Sasaki
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Saiji
authors.initials: S
authors.lastname: Ohga
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamitani
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohshima
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawanami
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D017564:Radiation Pneumonitis / Q000601:surgery*; D016634:Radiosurgery
keywords: Radiation pneumonitis; interstitial changes; stereotactic radiation therapy