title: Bee Venom Acupuncture Augments Anti-Inflammation in the Peripheral Organs of hSOD1G93A Transgenic Mice.
abstract: Amyotrophic lateral sclerosis (ALS) includes progressively degenerated motor neurons in the brainstem, motor cortex, and spinal cord. Recent reports demonstrate the dysfunction of multiple organs, including the lungs, spleen, and liver, in ALS animals and patients. Bee venom acupuncture (BVA) has been used for treating inflammatory diseases in Oriental Medicine. In a previous study, we demonstrated that BV prevented motor neuron death and increased anti-inflammation in the spinal cord of symptomatic hSOD1G93A transgenic mice. In this study, we examined whether BVA's effects depend on acupuncture point (ST36) in the organs, including the liver, spleen and kidney, of hSOD1G93A transgenic mice. We found that BV treatment at ST36 reduces inflammation in the liver, spleen, and kidney compared with saline-treatment at ST36 and BV injected intraperitoneally in symptomatic hSOD1G93A transgenic mice. Those findings suggest that BV treatment combined with acupuncture stimulation is more effective at reducing inflammation and increasing immune responses compared with only BV treatment, at least in an ALS animal model.
authors.affiliation: Division of Clinical Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea. enddlsh@kiom.re.kr.
authors.forename: Sun-Hwa
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Executive Director of R&D, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea. smchoi@kiom.re.kr.
authors.forename: Sun-Mi
authors.initials: SM
authors.lastname: Choi
authors.affiliation: Division of Clinical Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea. yej4823@hanmail.net.
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Yang
mesh_terms: D015670:Acupuncture Therapy; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000628:therapy*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001514:Bee Venoms / Q000008:administration & dosage* / Q000627:therapeutic use; D002135:Calcium-Binding Proteins / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008822:Mice, Transgenic; D008840:Microfilament Proteins / Q000378:metabolism; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics; D000072105:Superoxide Dismutase-1; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C491049:Aif1 protein, mouse; D000893:Anti-Inflammatory Agents; D001514:Bee Venoms; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D014409:Tumor Necrosis Factor-alpha; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1
keywords: amyotrophic lateral sclerosis (ALS); anti-inflammation; bee venom acupuncture (BVA)