title: [Prevalence of intolerance to salicylates in patients with nasal polyposis].
abstract: BACKGROUND
  Salicylates intolerance is related to alteration in the metabolism of arachidonic acid leading to increased leukotrienes. The condition may be manifested with respiratory, skin or systemic symptoms or associated with sinonasal polyposis. Salicylates are present in anti-inflammatory drugs, cosmetics products and food.
  
  
  OBJECTIVE
  To determine the prevalence of salicylates intolerance in patients with sinonasal polyposis presenting to Clinical Immunology and Allergy and Otolaryngology Service, CMN 20 Noviembre, Mexico City.
  
  
  METHODS
  An observational, descriptive, cross sectional study included patients with sinonasal polyposis. The sample size was 49 patients, and variables were compared using STATISTICA 8.0.
  
  
  RESULTS
  The prevalence of sinonasal polyposis was 4% of the study group, predominantly in females; only 24% of the population had an ideal weight, the salicylates intolerance prevalence was 53%, and the Samter triad was 31%.
  
  
  CONCLUSIONS
  Sinonasal polyposis has an inflammatory disease pattern. Its pathophysiology is not yet fully established and in this study was related to obesity and persistent sinusitis. The most feared complication recurrence is associated with salicylates intolerance. The study found a slight increase of recurrence in the group of intolerance, with no statistically significant difference, possibly related to the sample size.
authors.affiliation: Servicio de Inmunología Clínica y Alergia, Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Distrito Federal, México. jaiselcastilla@hotmail.com.
authors.forename: Jaisel Luz
authors.initials: JL
authors.lastname: Castilla-Rodríguez
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Vargas-Camaño
authors.forename: Rodrigo Alberto
authors.initials: RA
authors.lastname: Rodríguez-Briceño
authors.forename: Jorge
authors.initials: J
authors.lastname: Galicia-Tapia
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Castrejón-Vázquez
keywords: salicylates intolerance; sinonasal polyposis