title: Routine systemic antibiotic prophylaxis for burn injuries in developing countries: A best evidence topic (BET).
abstract: BACKGROUND
  Burns are common in low- and middle-income countries (LMICs) and complicated by unhygienic conditions, malnutrition, use of high-risk homemade dressings and delayed presentation. Resultantly, use of routine systemic antibiotic prophylaxis (SAP) to prevent wound infection is common practice despite this intervention being abandoned in high-income countries due to increased antimicrobial resistance and non-bacterial suprainfection.
  
  
  METHODS
  A best evidence topic (BET) was constructed using a structured protocol. The question addressed was: In LMICs, does routine use of SAP reduce burn wound infection, morbidity or mortality?
  
  
  RESULTS
  From 704 retrieved records, 48 reports met criteria to be examined. Of those, 3 studies represented the best available evidence. Together, two randomized clinical trials (RCTs) and a retrospective cohort study reported no difference in the proportion of wound infection, any infection or length of hospital stay between SAP groups and controls. One RCT described a greater proportion of wounds infected with P. aeruginosa among SAP arms compared to controls. The studies had few participants and significant methodological weaknesses.
  
  
  CONCLUSIONS
  On the basis of limited, currently available evidence, the use of SAP cannot be recommended for patients in LMICs that present soon after burn injury.
authors.affiliation: Department of Surgery, University of Washington, Seattle, USA; Department of Surgery, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address: stewarb@uw.edu.
authors.forename: Barclay T
authors.initials: BT
authors.lastname: Stewart
authors.affiliation: Department of Surgery, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana.
authors.forename: Adam
authors.initials: A
authors.lastname: Gyedu
authors.affiliation: Department of Surgery, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana.
authors.forename: Pius
authors.initials: P
authors.lastname: Agbenorku
authors.affiliation: Department of Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Richcane
authors.initials: R
authors.lastname: Amankwa
authors.affiliation: Surgeons OverSeas (SOS), New York, NY, USA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Surgery, Columbia University, New York, NY, USA.
authors.forename: Adam L
authors.initials: AL
authors.lastname: Kushner
authors.affiliation: UW Medicine Regional Burn Center, USA; Department of Surgery, Harborview Medical Center, Seattle, WA, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Gibran
mesh_terms: D019072:Antibiotic Prophylaxis; D002056:Burns / Q000150:complications*; D003906:Developing Countries; D006801:Humans; D014946:Wound Infection / Q000209:etiology* / Q000517:prevention & control*
keywords: Antibiotic prophylaxis; Burn; Developing countries; Global surgery