title: Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort.
abstract: To determine the association between duration of untreated psychosis (DUP) and symptoms remission in a hospitalized first-episode psychosis cohort.
  
  
  
  Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed.
  
  
  
  Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group (P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission (HR: 3.04, 95% CI 1.2-7.5).
  
  
  
  DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms.
authors.affiliation: Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.|Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.
authors.forename: Alfonso
authors.identifier: 0000-0003-4716-4021
authors.initials: A
authors.lastname: González-Valderrama
authors.affiliation: Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.
authors.forename: Carmen Paz
authors.initials: CP
authors.lastname: Castañeda
authors.affiliation: Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.
authors.forename: Cristián
authors.initials: C
authors.lastname: Mena
authors.affiliation: Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.|Department of Psychiatry, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
authors.forename: Juan
authors.initials: J
authors.lastname: Undurraga
authors.affiliation: Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.
authors.forename: Pilar
authors.initials: P
authors.lastname: Mondaca
authors.affiliation: Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.
authors.forename: Matías
authors.initials: M
authors.lastname: Yañez
authors.affiliation: Departamento de Salud Publica, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Paula
authors.initials: P
authors.lastname: Bedregal
authors.affiliation: Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.|Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.
authors.forename: Ruben
authors.initials: R
authors.lastname: Nachar
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002677:Chile; D002908:Chronic Disease; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D011594:Psychometrics; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology; D012074:Remission Induction; D012559:Schizophrenia / Q000175:diagnosis* / Q000628:therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents
keywords: duration of untreated psychosis; early intervention; negative symptom; psychosis; schizophrenia