title: Real-time in situ monitoring via europium emission of the photo-release of antitumor cisplatin from a Eu-Pt complex.
abstract: A water-soluble light-responsive antitumor agent, PtEuL, based on a cisplatin-linked europium-cyclen complex has been synthesized and evaluated for controlled cisplatin release by linear/two-photon excitation in vitro with concomitant turn-on and long-lived europium emission as a responsive traceable signal.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR. dkwong@hkbu.edu.hk klwong@hkbu.edu.hk.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Li
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Lan
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Chan
authors.forename: Lijun
authors.initials: L
authors.lastname: Jiang
authors.forename: Lixiong
authors.initials: L
authors.lastname: Dai
authors.forename: Daniel W J
authors.initials: DW
authors.lastname: Kwong
authors.forename: Michael Hon-Wah
authors.initials: MH
authors.lastname: Lam
authors.forename: Ka-Leung
authors.initials: KL
authors.lastname: Wong
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000528:radiation effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D002945:Cisplatin / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000528:radiation effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000528:radiation effects; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D016903:Drug Monitoring / Q000379:methods*; D005063:Europium / Q000737:chemistry* / Q000528:radiation effects; D006801:Humans; D049408:Luminescent Agents / Q000737:chemistry* / Q000528:radiation effects; D008163:Luminescent Measurements / Q000379:methods; D017785:Photons; D014466:Ultraviolet Rays
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D003692:Delayed-Action Preparations; D049408:Luminescent Agents; D005063:Europium; D002945:Cisplatin