title: Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.
abstract: We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.
authors.affiliation: 1] Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan [2] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan [3] Research Fellow of the Japan Society for the Promotion of Science.
authors.forename: Satomi
authors.initials: S
authors.lastname: Kikuta
authors.affiliation: Graduate School and Faculty of Pharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University, 1-78 Shoumachi, Tokushima 770-8505, Japan.
authors.forename: Yukiyo
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Graduate School and Faculty of Pharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University, 1-78 Shoumachi, Tokushima 770-8505, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamamura
authors.affiliation: 1] Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan [2] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tamura
authors.affiliation: Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Homma
authors.affiliation: 1] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan [2] Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Japan.
authors.forename: Yuchio
authors.initials: Y
authors.lastname: Yanagawa
authors.affiliation: Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Tamura
authors.affiliation: Graduate School and Faculty of Pharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University, 1-78 Shoumachi, Tokushima 770-8505, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Kasahara
authors.affiliation: 1] Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan [2] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Osanai
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D003287:Contrast Media / Q000737:chemistry*; D005260:Female; D059330:GABAergic Neurons / Q000378:metabolism / Q000473:pathology; D055879:Gene Knock-In Techniques; D007150:Immunohistochemistry; D020267:MPTP Poisoning / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011859:Radiography; D012720:Severity of Illness Index; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D003287:Contrast Media; D008345:Manganese; D014446:Tyrosine 3-Monooxygenase; D002118:Calcium