title: Baseline higher peritoneal transport had been associated with worse nutritional status of incident continuous ambulatory peritoneal dialysis patients in Southern China: a 1-year prospective study.
abstract: The aim of the present study was to investigate the relationship between baseline peritoneal transport types and nutritional status in Chinese continuous ambulatory peritoneal dialysis (CAPD) patients. In the present single-centre, prospective study, incident CAPD patients were included from 15 April 2010 to 31 December 2011 and were followed up for 12 months. According to the results of baseline peritoneal equilibration test, patients were divided into lower peritoneal transport group (lower transporters) and higher peritoneal transport group (higher transporters). Nutritional status was evaluated by both subjective global assessment (SGA) and protein-energy wasting (PEW) score. The body composition parameters were assessed by body impedance analysis. A total of 283 CAPD patients were included in the study, of which 171 (60.4 %) were males with a mean age of 47.0 (sd 14.9) years. Compared with lower transporters (n 92), higher transporters (n 181) had lower levels of serum albumin (37.1 (sd 4.3) v. 39.6 (sd 4.3) g/l, P< 0.001), serum pre-albumin (356 (sd 99) v. 384 (sd 90) mg/l, P= 0.035), phase angle (6.15 (sd 0.39) v. 6.27 (sd 0.47)°, P< 0.05) and higher rate of malnutrition defined by SGA (52.5 v. 25.0%, P< 0.001) and PEW score (37.0 v. 14.1 %, P< 0.001) at 1-year of follow-up. Baseline higher peritoneal transport, analysed by multivariate binary logistic regressions, was independently associated with malnutrition (SGA mild to moderate and severe malnutrition: OR 3.43, 95% CI 1.69, 6.96, P< 0.01; PEW: OR 2.40, 95% CI 1.08, 5.31, P= 0.03). It was concluded that baseline higher peritoneal transport was independently associated with worse nutritional status of CAPD patients in Southern China.
authors.affiliation: Department of Nephrology,The First Affiliated Hospital, Sun Yat-sen University,58th Zhongshan Road II,Guangzhou510080,China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Nephrology,The First Affiliated Hospital, Sun Yat-sen University,58th Zhongshan Road II,Guangzhou510080,China.
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.affiliation: Department of Nephrology,The First Affiliated Hospital, Sun Yat-sen University,58th Zhongshan Road II,Guangzhou510080,China.
authors.forename: Qunying
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Nephrology,The First Affiliated Hospital, Sun Yat-sen University,58th Zhongshan Road II,Guangzhou510080,China.
authors.forename: Qiongqiong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Nephrology,The First Affiliated Hospital, Sun Yat-sen University,58th Zhongshan Road II,Guangzhou510080,China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Yi
authors.affiliation: Department of Nephrology,The First Affiliated Hospital, Sun Yat-sen University,58th Zhongshan Road II,Guangzhou510080,China.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Nephrology,The First Affiliated Hospital, Sun Yat-sen University,58th Zhongshan Road II,Guangzhou510080,China.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Nephrology,The First Affiliated Hospital, Sun Yat-sen University,58th Zhongshan Road II,Guangzhou510080,China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
mesh_terms: D000328:Adult; D001692:Biological Transport; D001823:Body Composition; D002681:China; D017097:Electric Impedance; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D044342:Malnutrition / Q000453:epidemiology; D008875:Middle Aged; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D010537:Peritoneum / Q000378:metabolism*; D011228:Prealbumin / Q000032:analysis; D011446:Prospective Studies; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D012709:Serum Albumin / Q000032:analysis
chemical_list: D011228:Prealbumin; D012709:Serum Albumin
keywords: Continuous ambulatory peritoneal dialysis; Malnutrition; Peritoneal equilibrium test; Peritoneal transport