title: MicroRNA-224: as a potential target for miR-based therapy of cancer.
abstract: MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. Increasing studies have shown that microRNAs play important roles in multiple biological pathways. For instance, aberrant expression of microRNA-224 (miR-224) plays a vital role in tumor biology in various types of human cancer. Here, we aim to summarize the molecular mechanisms that lead to the overexpression of miR-224 in cancers, analyze the effect of miR-224 on tumor biology, and reveal the clinical significance of miR-224. MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment.
authors.affiliation: Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu, China. jsszlyypw@163.com.|Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China. jsszlyypw@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Fan
authors.affiliation: Department of General Surgery, Huaian Second People's Hospital, Huaian, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Mao
authors.affiliation: Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Wu
authors.affiliation: Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China. tjh_doctor@163.com.|Department of General Surgery, The Affiliated Jiangsu Cancer Hospital, Nanjing Medical University, 42Bai Zi Ting Road, Nanjing, Jiangsu, 210000, China. tjh_doctor@163.com.
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Tang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000627:therapeutic use; D063646:Carcinogenesis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000627:therapeutic use; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; C546140:MIRN224 microRNA, human; D035683:MicroRNAs
keywords: Biomaker; Cancer; MicroRNA; MicroRNA-224; Therapy