title: A fluorescent turn-on H2S-responsive probe: design, synthesis and application.
abstract: Hydrogen sulfide (H2S) is considered as the third signaling molecule in vivo and it plays an important role in various physiological processes and pathological processes in vivo, such as vasodilation, apoptosis, neurotransmission, ischemia/reperfusion-induced injury, insulin secretion and inflammation. Developing a highly selective and sensitive method that can detect H2S in the biological system is very important. In this work, a colorimetric and "turn-on" fluorescent probe is developed. Furthermore, this probe displays a highly selective response to H2S in aqueous solution and possesses good capability for bioimaging H2S without interference in living cells. The results suggest that a H2S-selective probe has good water-solubility, biocompatibility and cell-penetrability and can serve as an efficient tool for probing H2S in the cell level.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology of the Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. yinj@mail.ccnu.edu.cn.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Chen
authors.forename: Sheng Hua
authors.initials: SH
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
mesh_terms: D003124:Colorimetry; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D006862:Hydrogen Sulfide