title: The effect of lifestyle modification and glycemic control on the efficiency of sildenafil citrate in patients with erectile dysfunction due to type-2 diabetes mellitus.
abstract: OBJECTIVE
  We evaluated the effect of lifestyle modifications and glycemic control on the efficiency of sildenafil citrate in patients with type-2 diabetes (T2DM) and erectile dysfunction (ED).
  
  
  METHODS
  Eighty-three men with ED due to T2DM were included in the study. The Group 1 (n = 41) patients received lifestyle modifications (diet and exercise), and medical treatment for intensive glycemic control. In Group 2 (n = 42), in addition to the intensive glycemic control, the patients were given sildenafil citrate® 100 mg for 2-3 per weeks. The changes in ED were compared between the two groups after three months of treatment.
  
  
  RESULTS
  The mean age was 54.9 ± 9.1 (26-75) years. An increase in the IIEF-5 scores was observed in 23 of 41 patients in Group 1 (44.2%) and 29 of 42 in Group 2 (55.8%). When the changes of the IIEF-5 scores were evaluated, the mean increase was 2.5 in Group 1, and 5.0 in Group 2 (p = 0.012). The mean IIEF changes according to the duration of diabetes were 4.8 in <5 years, 3.6 in 5-10 years and 1.6 in >10 years (p = 0.021).
  
  
  CONCLUSIONS
  Glycemic control and lifestyle changes are not solely adequate for a better sexual function in ED due to diabetes, and sildenafil citrate should be used additionally.
authors.affiliation: a Department of Urology , Ankara Numune Research and Training Hospital , Ankara , Turkey.
authors.forename: Utku
authors.initials: U
authors.lastname: Kirilmaz
authors.affiliation: a Department of Urology , Ankara Numune Research and Training Hospital , Ankara , Turkey.
authors.forename: Ozer
authors.initials: O
authors.lastname: Guzel
authors.affiliation: a Department of Urology , Ankara Numune Research and Training Hospital , Ankara , Turkey.
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Aslan
authors.affiliation: a Department of Urology , Ankara Numune Research and Training Hospital , Ankara , Turkey.
authors.forename: Melih
authors.initials: M
authors.lastname: Balci
authors.affiliation: a Department of Urology , Ankara Numune Research and Training Hospital , Ankara , Turkey.
authors.forename: Altug
authors.initials: A
authors.lastname: Tuncel
authors.affiliation: a Department of Urology , Ankara Numune Research and Training Hospital , Ankara , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Atan
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology; D038321:Glycemic Index; D006801:Humans; D008297:Male; D008875:Middle Aged; D040242:Risk Reduction Behavior; D000068677:Sildenafil Citrate / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate
keywords: Erectile dysfunction; glisemic control; lifestyle modification; type-2 diabetes mellitus