title: Mouse Models of Uncomplicated and Fatal Malaria.
abstract: Mouse models have demonstrated utility in delineating the mechanisms underlying many aspects of malaria immunology and physiology. The most common mouse models of malaria employ the rodent-specific parasite speciesPlasmodium berghei,P. yoelii, andP. chabaudi, which elicit distinct pathologies and immune responses and are used to model different manifestations of human disease.In vitroculture methods are not well developed for rodentPlasmodiumparasites, which thus requirein vivomaintenance. Moreover, physiologically relevant immunological processes are best studiedin vivo. Here, we detail the processes of infecting mice withPlasmodium, maintaining the parasitein vivo, and monitoring parasite levels and health parameters throughout infection.
authors.affiliation: Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Huang
authors.affiliation: Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Pearman
authors.affiliation: Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
authors.forename: Charles C
authors.initials: CC
authors.lastname: Kim