title: Rescue of long-term memory after reconsolidation blockade.
abstract: Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdown of either Zif268 or Arc levels in the brain, and inhibition of protein synthesis, after a brief recall results in a non-recoverable retrograde amnesia, known as reconsolidation blockade. These experimental manipulations are seen as key proof for the existence of reconsolidation. However, here we demonstrate that despite disrupting the molecular correlates of reconsolidation in the hippocampus, rodents are still able to recover contextual memories. Our results challenge the view that reconsolidation is a separate memory process and instead suggest that the molecular events activated initially at recall act to constrain premature extinction.
authors.affiliation: Neuroscience and Mental Health Research Institute, Cardiff University, Haydn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Trent
authors.affiliation: Research and Innovations Services, Cardiff University, 30-36 Newport Road, Cardiff CF24 0ED, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Barnes
authors.affiliation: 1] Neuroscience and Mental Health Research Institute, Cardiff University, Haydn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK [2] MRC Centre for Neuropsychiatric Genetics and Genomics, Haydn Ellis Building, Cardiff University, Maindy Road, Cardiff CF24 4HQ, UK.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Hall
authors.affiliation: 1] Neuroscience and Mental Health Research Institute, Cardiff University, Haydn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK [2] School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
authors.forename: Kerrie L
authors.initials: KL
authors.lastname: Thomas
mesh_terms: D000648:Amnesia, Retrograde / Q000235:genetics*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D003213:Conditioning, Psychological; D003598:Cytoskeletal Proteins / Q000235:genetics*; D051766:Early Growth Response Protein 1 / Q000235:genetics*; D005239:Fear; D055785:Gene Knockdown Techniques; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology; D000069077:Memory Consolidation / Q000502:physiology*; D057567:Memory, Long-Term / Q000502:physiology*; D011939:Mental Recall; D009419:Nerve Tissue Proteins / Q000235:genetics*; D051381:Rats
chemical_list: D003598:Cytoskeletal Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D009419:Nerve Tissue Proteins; C092069:activity regulated cytoskeletal-associated protein