title: Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol.
abstract: Corticobasal ganglia networks coursing through the striatum are key structures for reward-guided behaviors. The ventral striatum (nucleus accumbens (nAc)) and its reciprocal connection with the ventral tegmental area (VTA) represent a primary component of the reward system, but reward-guided learning also involves the dorsal striatum and dopaminergic inputs from the substantia nigra. The majority of neurons in the striatum (>90%) are GABAergic medium spiny neurons (MSNs), but both the input to and the output from these neurons are dynamically controlled by striatal interneurons. Dopamine is a key neurotransmitter in reward and reward-guided learning, and the physiological activity of GABAergic and cholinergic interneurons is regulated by dopaminergic transmission in a complex manner. Here we review the role of striatal interneurons in modulating striatal output during drug reward, with special emphasis on alcohol.
authors.affiliation: Addiction Biology Unit, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, P.O. Box 410, 405 30 Gothenburg, Sweden.
authors.forename: Rhona
authors.initials: R
authors.lastname: Clarke
authors.affiliation: Addiction Biology Unit, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, P.O. Box 410, 405 30 Gothenburg, Sweden.
authors.forename: Louise
authors.initials: L
authors.lastname: Adermark
mesh_terms: D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D059329:Cholinergic Neurons / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology* / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D059330:GABAergic Neurons / Q000502:physiology; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D012201:Reward; D019966:Substance-Related Disorders / Q000503:physiopathology
chemical_list: D004298:Dopamine