title: A new phenyldilactone from Lespedeza cuneata.
abstract: A new phenyldilactone, maysedilactone B (1), together with twenty known compounds, were isolated from the aerial parts of Lespedeza cuneata. The structural elucidation of the isolated compounds was primarily based on HR-ESI-MS, IR and 1D and 2D NMR analyses. Compounds 1-8 and 15-21 were tested for cytotoxicity against four human tumor cell lines (A549, HCT116, SKOV3, and HepG2) using MTT method in vitro, while no significant activities were observed for the evaluated compounds.
authors.affiliation: a School of Pharmacy, Shanghai Jiao Tong University , Shanghai 200240 , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: b School of Pharmacy, Second Military Medical University , Shanghai 20033 , China.
authors.forename: Ji
authors.initials: J
authors.lastname: Ye
authors.affiliation: a School of Pharmacy, Shanghai Jiao Tong University , Shanghai 200240 , China.
authors.forename: Yang-Guo
authors.initials: YG
authors.lastname: Xie
authors.affiliation: a School of Pharmacy, Shanghai Jiao Tong University , Shanghai 200240 , China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Pan
authors.affiliation: a School of Pharmacy, Shanghai Jiao Tong University , Shanghai 200240 , China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: a School of Pharmacy, Shanghai Jiao Tong University , Shanghai 200240 , China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Qian
authors.affiliation: a School of Pharmacy, Shanghai Jiao Tong University , Shanghai 200240 , China.
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029884:Lespedeza / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; C000608637:maysedilactone B
keywords: Leguminosae; Lespedeza cuneata; chemical constituents; cytotoxicity; phenyldilactone