title: The impact of the concentration of drug binding plasma proteins on drug distribution according to Øie-Tozer's model.
abstract: 1. New equations have been developed from an updated version of Øie-Tozer's model expressing how the free concentration and volume of distribution change in relation to changes in the concentration of drug binding plasma proteins. This updated model accommodates more than one drug binding plasma protein to contribute to the plasma protein binding. 2. Demonstrations of the model show that variability in the concentration of one plasma protein has considerably less impact on the free drug concentration and volume of distribution if other plasma proteins contribute to binding, than if they don't.
authors.affiliation: a Department of Pharmaceutical Biosciences, Division of Pharmaceutical Bioinformatics , Biomedical Centre, Uppsala University , Uppsala , Sweden.
authors.forename: Andreas Mats
authors.initials: AM
authors.lastname: Svennebring
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D003198:Computer Simulation; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D001798:Blood Proteins; D004364:Pharmaceutical Preparations
keywords: Disposition; dose fraction; free fraction; orosomucoid; serum albumin