title: Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria.
abstract: Guanidinoacetic acid (GAA) is a natural precursor of creatine, and a possible substrate for the creatine kinase (CK) enzyme system, serving as a creatine mimetic. Its direct role in cellular bioenergetics has been confirmed in several studies, however GAA utilization by CK seems to be a second-rate as compared to creatine, and compartment-dependent. Here we discuss various factors that might affect GAA use in high-energy phosphoryl transfer in the cytosol and mitochondria.
authors.affiliation: Biomedical Sciences Department, Faculty of Sport and PE, University of Novi Sad, Lovcenska 16, Novi Sad, 21000, Serbia. sergej.ostojic@chess.edu.rs.
authors.forename: Sergej M
authors.initials: SM
authors.lastname: Ostojic
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D003401:Creatine / Q000378:metabolism*; D003402:Creatine Kinase / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*
chemical_list: D003402:Creatine Kinase; C004946:glycocyamine; D003401:Creatine; D005998:Glycine
keywords: Bioenergetics; Creatine; Creatine kinase; Guanidinoacetic acid; Mitochondria