title: Surface Plasmon Resonance Biosensor Based on Smart Phone Platforms.
abstract: We demonstrate a fiber optic surface plasmon resonance (SPR) biosensor based on smart phone platforms. The light-weight optical components and sensing element are connected by optical fibers on a phone case. This SPR adaptor can be conveniently installed or removed from smart phones. The measurement, control and reference channels are illuminated by the light entering the lead-in fibers from the phone's LED flash, while the light from the end faces of the lead-out fibers is detected by the phone's camera. The SPR-sensing element is fabricated by a light-guiding silica capillary that is stripped off its cladding and coated with 50-nm gold film. Utilizing a smart application to extract the light intensity information from the camera images, the light intensities of each channel are recorded every 0.5 s with refractive index (RI) changes. The performance of the smart phone-based SPR platform for accurate and repeatable measurements was evaluated by detecting different concentrations of antibody binding to a functionalized sensing element, and the experiment results were validated through contrast experiments with a commercial SPR instrument. This cost-effective and portable SPR biosensor based on smart phones has many applications, such as medicine, health and environmental monitoring.
authors.affiliation: School of Physics and Optoelectronic Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Physics and Optoelectronic Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Physics and Optoelectronic Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Shimeng
authors.initials: S
authors.lastname: Chen
authors.affiliation: 1] State Key Laboratory of Fine Chemical [2] School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Cheng
authors.affiliation: 1] State Key Laboratory of Fine Chemical [2] School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, China.
authors.forename: Hanqi
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Physics and Optoelectronic Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D005336:Fiber Optic Technology; D006046:Gold / Q000737:chemistry; D008027:Light; D012031:Refractometry; D000068997:Smartphone; D020349:Surface Plasmon Resonance
chemical_list: D006046:Gold