title: Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis.
abstract: Osteoarthritis (OA) is one of the most prevalent forms of joint disorder, associated with a tremendous socioeconomic burden worldwide. Various non-genetic and lifestyle-related factors such as aging and obesity have been recognized as major risk factors for OA, underscoring the potential role for epigenetic regulation in the pathogenesis of the disease. OA-associated epigenetic aberrations have been noted at the level of DNA methylation and histone modification in chondrocytes. These epigenetic regulations are implicated in driving an imbalance between the expression of catabolic and anabolic factors, leading eventually to osteoarthritic cartilage destruction. Cellular senescence and metabolic abnormalities driven by OA-associated risk factors appear to accompany epigenetic drifts in chondrocytes. Notably, molecular events associated with metabolic disorders influence epigenetic regulation in chondrocytes, supporting the notion that OA is a metabolic disease. Here, we review accumulating evidence supporting a role for epigenetics in the regulation of cartilage homeostasis and OA pathogenesis.
authors.affiliation: Department of Biological Sciences, Seoul National University, Seoul 151-747, Korea.
authors.forename: Hyeonkyeong
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences, Seoul National University, Seoul 151-747, Korea.
authors.forename: Donghyun
authors.initials: D
authors.lastname: Kang
authors.affiliation: Department of Biological Sciences, Seoul National University, Seoul 151-747, Korea.
authors.forename: Yongsik
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Department of Biological Sciences, Seoul National University, Seoul 151-747, Korea.
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000818:Animals; D019902:Chondrocytes / Q000378:metabolism*; D044127:Epigenesis, Genetic; D006801:Humans; D010003:Osteoarthritis / Q000235:genetics* / Q000378:metabolism*
keywords: cartilage; chondrocytes; epigenetics; metabolism; osteoarthritis