title: Synergistic activation of quorum sensing in Vibrio harveyi.
abstract: Autoinducer-2 (AI-2) has been suggested to serve as a ubiquitous quorum sensing (QS) signal that mediates intra- and interspecies cross-talk between bacteria. To add tools for the study of its function in bacterial communication, we present a new and an improved synthetic route to AI-2 and aromatic analogues. We used this strategy to prepare naphthyl-DPD, and observed remarkably high synergistic activity at low nanomolar concentrations for this analogue in Vibrio harveyi.
authors.affiliation: Department of Chemistry and the National Institute for Biotechnology in the Negev, Be'er Sheva 84105, Israel.
authors.forename: Aviad
authors.initials: A
authors.lastname: Mandabi
authors.affiliation: Department of Chemistry and the National Institute for Biotechnology in the Negev, Be'er Sheva 84105, Israel.
authors.forename: Hadas
authors.initials: H
authors.lastname: Ganin
authors.affiliation: Department of Chemistry and the National Institute for Biotechnology in the Negev, Be'er Sheva 84105, Israel. Electronic address: meijler@bgu.ac.il.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Meijler
mesh_terms: D006714:Homoserine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015394:Molecular Structure; D053038:Quorum Sensing / Q000187:drug effects*; D014733:Vibrio / Q000187:drug effects* / Q000378:metabolism
chemical_list: D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine
keywords: AI-2; DPD; Quorum sensing; V. harveyi