title: Trends of fluoroquinolone-resistant Escherichia coli amongst urinary isolates in children: a 10 year surveillance study.
abstract: We evaluated 3122 children with E. coli urinary isolates over a 10 year period in order to assess the emergence of fluoroquinolone resistance. Susceptibilities remained stable; however, hospitalized children had a statistically higher risk of developing fluoroquinolone-resistant isolates when compared with outpatients. Stewardship monitoring of fluoroquinolone use amongst hospitalized children is warranted.
authors.affiliation: Cooper University Hospital, Department of Pharmacy, Camden, NJ, USA.
authors.forename: Lucia
authors.initials: L
authors.lastname: Rosé
authors.affiliation: Thomas Jefferson University Hospital, Philadelphia, PA, USA.
authors.forename: Marissa M
authors.initials: MM
authors.lastname: Coulter
authors.affiliation: Alfred I. duPont Hospital for Children, Department of Pediatrics, Wilmington, DE, USA.
authors.forename: Shannon
authors.initials: S
authors.lastname: Chan
authors.affiliation: Nemours Biomedical Research, Wilmington, DE, USA.|Department of Food and Resource Economics, University of Delaware, Newark, DE, USA.
authors.forename: Jobayer
authors.initials: J
authors.lastname: Hossain
authors.affiliation: Infectious Diseases Division, Department of Pediatrics, Vanderbilt University, Nashville, TN, USA.
authors.forename: M Cecilia
authors.initials: MC
authors.lastname: Di Pentima
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D062665:Epidemiological Monitoring; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology / Q000652:urine; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D064704:Levofloxacin / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D064704:Levofloxacin