title: Preventing stem cell transplantation-associated viral infections using T-cell therapy.
abstract: Hematopoietic stem cell transplantation is the treatment of choice for many hematologic malignancies and genetic diseases. However, viral infections continue to account for substantial post-transplant morbidity and mortality. While antiviral drugs are available against some viruses, they are associated with significant side effects and are frequently ineffective. This review focuses on the immunotherapeutic strategies that have been used to prevent and treat infections over the past 20 years and outlines different refinements that have been introduced with the goal of moving this therapy beyond specialized academic centers.
authors.affiliation: Center for Cell & Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital & Texas Children's Hospital, 1102 Bates Street, Suite 1770, Houston, TX 77030, USA.
authors.forename: Ifigeneia
authors.initials: I
authors.lastname: Tzannou
authors.affiliation: Center for Cell & Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital & Texas Children's Hospital, 1102 Bates Street, Suite 1770, Houston, TX 77030, USA.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Leen
mesh_terms: D064591:Allografts; D030342:Genetic Diseases, Inborn / Q000276:immunology / Q000628:therapy*; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D014777:Virus Diseases / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*
keywords: T cells; adoptive immunotherapy; hematopoietic stem cell transplantation; viral infections