title: Illuminating neural circuits and behaviour in Caenorhabditis elegans with optogenetics.
abstract: The development of optogenetics, a family of methods for using light to control neural activity via light-sensitive proteins, has provided a powerful new set of tools for neurobiology. These techniques have been particularly fruitful for dissecting neural circuits and behaviour in the compact and transparent roundworm Caenorhabditis elegans. Researchers have used optogenetic reagents to manipulate numerous excitable cell types in the worm, from sensory neurons, to interneurons, to motor neurons and muscles. Here, we show how optogenetics applied to this transparent roundworm has contributed to our understanding of neural circuits.
authors.affiliation: Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA fangyen@seas.upenn.edu.
authors.forename: Christopher
authors.initials: C
authors.lastname: Fang-Yen
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Alkema
authors.affiliation: Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Aravinthan D T
authors.initials: AD
authors.lastname: Samuel
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D055355:Opsins / Q000502:physiology; D062308:Optogenetics / Q000379:methods*; D015398:Signal Transduction
chemical_list: D029742:Caenorhabditis elegans Proteins; D055355:Opsins
keywords: Caenorhabditis elegans; neural circuits; optogenetics