title: Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study.
abstract: Exposure to air particulate matter (PM) is associated with increased cardiovascular morbimortality. However, PM doesn't affect equally to all people, being the old cohort the most susceptible and studied. We hypothesized that another specific life phase, the middle-aged subpopulation, may be negatively affected. Therefore, the aim of this study was to analyze in vivo the acute biological impact of two environmental particles, Urban Air Particles from Buenos Aires and Residual Oil Fly Ash, on the cardiorespiratory system of middle-aged mice, evaluating oxidative metabolism and inflammation. Both PM provoked a local and systemic inflammatory response, leading to a reduced alveolar area in the lung, an epicard inflammation in the heart, an increment of IL-6, and a reduction on PON 1 activity in serum of middle-aged animals. The positive correlation of local parameters with systemic markers of oxidative stress and inflammation could be responsible for associations of cardiovascular morbimortality in this subpopulation.
authors.affiliation: Center for The Studies in Health and Environment, School of Science and Technology, National University of General San Martín, San Martín, Buenos Aires, Argentina; Committee for Scientific Research, La Plata, Buenos Aires, Argentina. Electronic address: naorona@gmail.com.
authors.forename: Nadia S
authors.initials: NS
authors.lastname: Orona
authors.affiliation: Center for The Studies in Health and Environment, School of Science and Technology, National University of General San Martín, San Martín, Buenos Aires, Argentina; Committee for Scientific Research, La Plata, Buenos Aires, Argentina.
authors.forename: Sebastián A
authors.initials: SA
authors.lastname: Ferraro
authors.affiliation: Center for The Studies in Health and Environment, School of Science and Technology, National University of General San Martín, San Martín, Buenos Aires, Argentina.
authors.forename: Francisco
authors.initials: F
authors.lastname: Astort
authors.affiliation: Institute of Cardiovascular Physiopathology, Department of Pathology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Celina
authors.initials: C
authors.lastname: Morales
authors.affiliation: Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Fernando
authors.initials: F
authors.lastname: Brites
authors.affiliation: Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Boero
authors.affiliation: Center for The Studies in Health and Environment, School of Science and Technology, National University of General San Martín, San Martín, Buenos Aires, Argentina.
authors.forename: Gisela
authors.initials: G
authors.lastname: Tiscornia
authors.affiliation: Center for The Studies in Health and Environment, School of Science and Technology, National University of General San Martín, San Martín, Buenos Aires, Argentina.
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Maglione
authors.affiliation: Experimental Atmospheric Pollution Laboratory, School of Medicine, Sao Paulo University, Sao Paulo, Brazil.
authors.forename: Paulo H N
authors.initials: PHN
authors.lastname: Saldiva
authors.affiliation: Department of Pharmaceutical Sciences, Hampton University, Hampton, VA, USA.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Yakisich
authors.affiliation: Center for The Studies in Health and Environment, School of Science and Technology, National University of General San Martín, San Martín, Buenos Aires, Argentina; Department of Histology and Embryology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Deborah R
authors.initials: DR
authors.lastname: Tasat
mesh_terms: D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D000818:Animals; D001118:Argentina; D015415:Biomarkers / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000276:immunology; D060729:Coal Ash / Q000032:analysis / Q000633:toxicity; D006321:Heart / Q000187:drug effects; D007249:Inflammation; D019570:Inhalation Exposure / Q000009:adverse effects* / Q000032:analysis; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects* / Q000276:immunology; D052638:Particulate Matter / Q000032:analysis / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D060729:Coal Ash; D015850:Interleukin-6; D052638:Particulate Matter
keywords: Aging; Cardiorespiratory system; Inflammation; Oxidative stress; Urban air pollution