title: Factors associated with the intensification of treatment in rheumatoid arthritis in clinical practice.
abstract: The aim of the present study was to analyse the patterns of treatment adjustment in rheumatoid arthritis (RA) patients with active disease in routine clinical care. This was a cross-sectional study of consecutive patients with RA conducted in five hospitals. Activity scales (DAS28-ESR) and function (HAQ) were measured, as well as whether ultrasound was performed as part of the assessment. Treatment decision (no changes/reduction/intensification) and time to the next scheduled visit were the outcomes variables. Associated factors were analysed by multilevel regression models. A total of 343 patients were included (77 % women, mean age 57 years, mean RA duration 10 years), of whom 44 % were in remission by DAS28. Treatment was continued in 202 (59 %) patients, reduced in 57 (16 %), and intensified in 83 (24 %). In the 117 patients with active RA (DAS28 ≥ 3.2), treatment was intensified in 61 (52 %). Factors associated with treatment intensification were physician and patient VAS, and DAS28, but not the centre. In the multilevel regression analysis with intensification of treatment as dependent variable, the following factors were significantly associated: DAS28 [OR 3.67 (95 % CI 2.43-5.52)], patient VAS [OR 1.04 (95 % CI 1.01-1.08)], and have performed an ultrasound [OR 3.36 (95 % CI 1.47-7.68)]. Factors associated with time to the next scheduled visit (an average of 4.3 months) were patient and physician VAS, DAS28, and centre. In clinical practice, half of the patients with active RA maintain or reduce the treatment. The decision to intensify treatment in active RA as recommended by a treat-to-target strategy is complex in practice.
authors.affiliation: Department of Rheumatology, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad de Las Palmas de Gran Canaria, Calle Barranco de La Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain. anarher@gobiernodecanarias.org.
authors.forename: Antonio
authors.initials: A
authors.lastname: Naranjo
authors.affiliation: Department of Rheumatology, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad de Las Palmas de Gran Canaria, Calle Barranco de La Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Cáceres
authors.affiliation: Complejo Hospitalario Universitario Materno Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Hernández-Beriaín
authors.affiliation: Department of Rheumatology, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad de Las Palmas de Gran Canaria, Calle Barranco de La Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Francisco
authors.affiliation: Department of Rheumatology, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad de Las Palmas de Gran Canaria, Calle Barranco de La Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
authors.forename: Soledad
authors.initials: S
authors.lastname: Ojeda
authors.affiliation: Hospital Dr. Molina Orosa, Lanzarote, Spain.
authors.forename: Sigrid
authors.initials: S
authors.lastname: Talaverano
authors.affiliation: Complejo Hospitalario Universitario Materno Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Nóvoa-Medina
authors.affiliation: Hospital Dr. Molina Orosa, Lanzarote, Spain.
authors.forename: José Adán
authors.initials: JA
authors.lastname: Martín
authors.affiliation: Hospital Universitario de Canarias, Tenerife, Spain.
authors.forename: Esmeralda
authors.initials: E
authors.lastname: Delgado
authors.affiliation: Hospital Universitario de Canarias, Tenerife, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Trujillo
authors.affiliation: Hospital Universitario NS Candelaria, Tenerife, Spain.
authors.forename: Fátima
authors.initials: F
authors.lastname: Álvarez
authors.affiliation: Hospital Universitario NS Candelaria, Tenerife, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Magdalena
authors.affiliation: Department of Rheumatology, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad de Las Palmas de Gran Canaria, Calle Barranco de La Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodríguez-Lozano
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy*; D003430:Cross-Sectional Studies; D017723:Drug Utilization Review; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009819:Office Visits / Q000639:trends; D010818:Practice Patterns, Physicians' / Q000639:trends*; D012074:Remission Induction; D012720:Severity of Illness Index; D013030:Spain; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents
keywords: DAS28; Rheumatoid arthritis; Treat to target; Ultrasonography