title: Star-Shaped, Biodegradable, and Elastomeric PLLA-PEG-POSS Hybrid Membrane With Biomineralization Activity for Guiding Bone Tissue Regeneration.
abstract: Multi-armed biodegradable polymers have attracted much attention in biomedical applications, due to their special structure and properties. However, multi-armed organic-inorganic hybrids with high mechanical properties and biomineralization activity have not been reported yet. Here, star-shaped poly-L-lactide-poly (ethylene glycol)-polyhedral oligomeric silsesquioxane (SPPS) hybrid membranes are fabricated for the first time for guiding bone regeneration applications by a photo-crosslinking method using inositol as a core. SPPS demonstrates tunable mechanical properties (5.8 ± 0.2 ∼ 130 ± 23 MPa in tensile modulus, 30 ± 6% ∼ 144 ± 13% in elongation, beyond 90% recovery), biodegradation, biomineralization activity and good osteoblast biocompatibility. These results suggest that our hybrids membrane may have promising applications in guiding bone regeneration.
authors.affiliation: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Xie
authors.affiliation: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Ge
authors.affiliation: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China. leiboaray@foxmail.com.|State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, China. leiboaray@foxmail.com.|National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China. leiboaray@foxmail.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Lei
authors.affiliation: College of Sciences, Xi'an University of Technology, Xi'an, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chen
authors.affiliation: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China. rayboo@xjtu.edu.cn, mapx@umich.edu.|Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, USA. rayboo@xjtu.edu.cn, mapx@umich.edu.|Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA. rayboo@xjtu.edu.cn, mapx@umich.edu.
authors.forename: Peter X
authors.initials: PX
authors.lastname: Ma
mesh_terms: D000818:Animals; D063566:Biodegradable Plastics / Q000737:chemistry*; D001861:Bone Regeneration; D002460:Cell Line; D020724:Elastomers / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D051379:Mice; D017646:Organosilicon Compounds / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D063566:Biodegradable Plastics; D020724:Elastomers; D008567:Membranes, Artificial; D017646:Organosilicon Compounds; D011091:Polyesters; D011108:Polymers; C521417:polyhedraloligosilsesquioxane; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); C000595209:polyethylene glycol 1000
keywords: biomineralization; bone tissue regeneration; hybrid structures; mechanical properties; silica-based biomaterials