title: Amyloidosis of the liver on shear wave elastography: case report and review of literature.
abstract: Amyloidosis is extremely rare, with an estimated 2225 new US cases reported annually. Signs and symptoms of the disease are subtle and imaging findings are not pathognomonic. Currently, diagnosis requires biopsy to demonstrate the deposition of amyloid. Elastography is a new imaging modality that evaluates tissue elasticity. It has shown to have efficacy in characterizing thyroid nodules, detecting prostate cancer, and staging liver fibrosis. We present a case of hepatic amyloidosis in a 51-year-old male that demonstrates significantly increased stiffness with a median value of 99.1 kPa (range 25.7-188.9 kPa) on shear-wave elastography (SWE) imaging, which is significantly higher than the cut-off range reported for cirrhosis on SWE (10.4-11.5 kPa). This finding raises the possibility that elastographic imaging may be sensitive to tissue mechanical changes induced by amyloid deposition.
authors.affiliation: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
authors.forename: Dmitry S
authors.initials: DS
authors.lastname: Trifanov
authors.affiliation: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. dhyani.manish@mgh.harvard.edu.
authors.forename: Manish
authors.identifier: http://orcid.org/0000-0002-2651-1859
authors.initials: M
authors.lastname: Dhyani
authors.affiliation: Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Jacob R
authors.initials: JR
authors.lastname: Bledsoe
authors.affiliation: Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Misdraji
authors.affiliation: Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Atul K
authors.initials: AK
authors.lastname: Bhan
authors.affiliation: Department of Hepatology, Medicine, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, MA, 02114, USA.
authors.forename: Raymond T
authors.initials: RT
authors.lastname: Chung
authors.affiliation: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Samir
mesh_terms: D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
keywords: Amyloidosis; Elastography; Liver biopsy; Liver fibrosis; SWE; Ultrasound elastography