title: Thyrotropin-secreting pituitary adenoma in an 11-year-old boy with type 1 autoimmune polyglandular syndrome.
abstract: Thyrotropinomas (TSHomas) are rare pituitary adenomas, particularly in childhood. We present here the case of an 11-year-old boy with type 1 autoimmune polyglandular syndrome (APS1) and TSHoma which was diagnosed by elevated thyroid - stimulating hormone and thyroid hormones levels without evident clinical signs of hyperthyroidism. He was underwent partial resection of the tumor via transsphenoidal approach and subsequently radiation therapy. Consequently, 1 year after radiotherapy, the patient developed growth hormone deficiency, three and half years after radiation became euthyroid, and five and half years after treatment - hypothyroid. This is the first case of the coexistence of these two rare endocrine diseases in one patient.
authors.forename: Nadia
authors.initials: N
authors.lastname: Mazerkina
authors.forename: Yuri
authors.initials: Y
authors.lastname: Trunin
authors.forename: Sergey
authors.initials: S
authors.lastname: Gorelyshev
authors.forename: Andrey
authors.initials: A
authors.lastname: Golanov
authors.forename: Boris
authors.initials: B
authors.lastname: Kadashev
authors.forename: Liudmila
authors.initials: L
authors.lastname: Shishkina
authors.forename: Daniil
authors.initials: D
authors.lastname: Rotin
authors.forename: Maxim
authors.initials: M
authors.lastname: Karmanov
authors.forename: Elizabet
authors.initials: E
authors.lastname: Orlova
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000378:metabolism*; D016884:Polyendocrinopathies, Autoimmune / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism*
chemical_list: D013972:Thyrotropin