title: Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers.
abstract: Amphiphilic polycations are an alternative to biocides but also toxic to mammalian cells. Antimicrobially active hydrophilic polycations based on 1,4-dibromo-2-butene and tetramethyl-1,3-propanediamine named PBI are not hemotoxic for porcine red blood cells with a hemocytotoxicity (HC50) of more than 40,000 μg · mL(-1). They are quickly killing bacterial cells at their MIC (minimal inhibitory concentration). The highest found selectivity HC50 /MIC is more than 20,000 for S. epidermidis. Investigations on sequentially prepared PBIs with defined molecular weight Mn and tailored end groups revealed that there is a dependence of antimicrobial activity and selectivity on Mn and nature of the end groups.
authors.affiliation: Chair of Biomaterials and Polymer Science, Department of biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Strassburg
authors.affiliation: Chair of Biomaterials and Polymer Science, Department of biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Kracke
authors.affiliation: Chair of Biomaterials and Polymer Science, Department of biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Wenners
authors.affiliation: Chair of Biomaterials and Polymer Science, Department of biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Jemeljanova
authors.affiliation: Chair of Biomaterials and Polymer Science, Department of biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.
authors.forename: Jannis
authors.initials: J
authors.lastname: Kuepper
authors.affiliation: Chair of Biomaterials and Polymer Science, Department of biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.
authors.forename: Hanne
authors.initials: H
authors.lastname: Petersen
authors.affiliation: Chair of Biomaterials and Polymer Science, Department of biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany. joerg.tiller@tu-dortmund.de.
authors.forename: Joerg C
authors.initials: JC
authors.lastname: Tiller
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D008567:Membranes, Artificial; D013212:Staphylococcus epidermidis / Q000254:growth & development*
chemical_list: D000890:Anti-Infective Agents; D008567:Membranes, Artificial
keywords: antimicrobial; non-toxic; polyionenes; polyquaternium; selective