title: A Prolonged Post-Operative Antibiotic Regimen Reduced the Rate of Prosthetic Joint Infection after Aseptic Revision Knee Arthroplasty.
abstract: BACKGROUND
  The aim of this study was to compare the prosthetic joint infection (PJI) rate after knee revision arthroplasty in two consecutive periods with different antibiotic prophylaxis: short (one day) versus long (five days).
  
  
  METHODS
  From January 2007 to September 2010 antibiotic prophylaxis consisted of 800 mg of teicoplanin and 2 g of ceftazidime intravenously and 1 g of ceftazidime two hours after the first dose. From October 2010, it was prolonged post-operatively using vancomycin and ceftazidime intravenously until the fifth day.
  
  
  RESULTS
  During the study period, 341 revision surgeries met the inclusion criteria. The PJI rate was lower in the long-prophylaxis group (2.2% versus 6.9%, p=0.049). Prolonged post-operative antibiotic treatment was the only variable associated independently with a lower rate of PJI (odds ratio [OR]: 0.27, 95% confidence interval [CI]: 0.07-0.99).
authors.affiliation: 1 Departments of Orthopedic Surgery, Hospital Clínic of Barcelona , Spain, Barcelona, Spain .
authors.forename: Guillem
authors.initials: G
authors.lastname: Claret
authors.affiliation: 1 Departments of Orthopedic Surgery, Hospital Clínic of Barcelona , Spain, Barcelona, Spain .
authors.forename: Eduard
authors.initials: E
authors.lastname: Tornero
authors.affiliation: 1 Departments of Orthopedic Surgery, Hospital Clínic of Barcelona , Spain, Barcelona, Spain .
authors.forename: Juan-Carlos
authors.initials: JC
authors.lastname: Martínez-Pastor
authors.affiliation: 1 Departments of Orthopedic Surgery, Hospital Clínic of Barcelona , Spain, Barcelona, Spain .
authors.forename: Mercè
authors.initials: M
authors.lastname: Piazuelo
authors.affiliation: 1 Departments of Orthopedic Surgery, Hospital Clínic of Barcelona , Spain, Barcelona, Spain .
authors.forename: Jésica
authors.initials: J
authors.lastname: Martínez
authors.affiliation: 2 Service of Infectious Diseases, Hospital Clínic of Barcelona, Spain, IDIBAPS, University of Barcelona , Barcelona, Spain .
authors.forename: Jordi
authors.initials: J
authors.lastname: Bosch
authors.affiliation: 2 Service of Infectious Diseases, Hospital Clínic of Barcelona, Spain, IDIBAPS, University of Barcelona , Barcelona, Spain .
authors.forename: Josep
authors.initials: J
authors.lastname: Mensa
authors.affiliation: 2 Service of Infectious Diseases, Hospital Clínic of Barcelona, Spain, IDIBAPS, University of Barcelona , Barcelona, Spain .
authors.forename: Alex
authors.initials: A
authors.lastname: Soriano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D001168:Arthritis / Q000453:epidemiology / Q000517:prevention & control*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D002442:Ceftazidime / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011182:Postoperative Care / Q000379:methods*; D016459:Prosthesis-Related Infections / Q000453:epidemiology / Q000517:prevention & control*; D012189:Retrospective Studies; D017334:Teicoplanin / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D014640:Vancomycin; D002442:Ceftazidime