title: Synthesis, nanoprecipitation and pH sensitivity of amphiphilic linear-dendritic hybrid polymers and hyperbranched-polydendrons containing tertiary amine functional dendrons.
abstract: The combination of linear polymers with dendritic chain-ends has led to numerous studies of linear-dendritic polymer hybrid materials. Interchain branching within the linear segment of these materials has recently extended this concept to the formation of soluble hyperbranched-polydendrons. Here, the introduction of amphiphilicity into hyperbranched-polydendrons has been achieved for the first time through the use of tertiary amine functional dendritic chain-ends and branched hydrophobic polymer segments. The synthesis and aqueous nanoprecipitation of these branched materials is compared with their linear-dendritic polymer analogues, showing that chain-end chemistry/generation, precipitation medium pH and polymer architecture are all capable of influencing the ability to generate nanoparticles, the resulting nanoparticle diameter and dispersity, and subsequent response to changes in pH.
authors.affiliation: Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK. srannard@liv.ac.uk.
authors.forename: Hannah E
authors.initials: HE
authors.lastname: Rogers
authors.forename: Pierre
authors.initials: P
authors.lastname: Chambon
authors.forename: Sam E R
authors.initials: SE
authors.lastname: Auty
authors.forename: Faye Y
authors.initials: FY
authors.lastname: Hern
authors.forename: Andrew
authors.initials: A
authors.lastname: Owen
authors.forename: Steve P
authors.initials: SP
authors.lastname: Rannard
mesh_terms: D000588:Amines / Q000737:chemistry; D000873:Anthracenes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D000588:Amines; D000873:Anthracenes; D013501:Surface-Active Agents; C501244:dendron