title: Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools.
abstract: Aging is accompanied by a progressive decline of endothelial function and a progressive drift toward a systemic pro-inflammatory status that has been designated "inflammaging". Both phenomena are accelerated and exacerbated in patients with the most common age-related diseases (ARDs), including cancer. The finding that chronic cell stress activates a pro-inflammatory program leading to acquisition of the senescence-associated secretory phenotype (SASP) and to the propagation of senescence to surrounding cells through the secretome, suggests that cell senescence may have a role in both processes. Here we: i) describe the role of cell senescence in endothelial dysfunction, ii) emphasize the contribution of the endothelial cell SASP to inflammaging, and iii) suggest that selective removal of senescent endothelial cells may not only hinder such harmful processes, but also reduce the risk of developing ARDs and their complications. Although in vivo detection and targeting of senescent endothelial cells are still being investigated, it is likely that therapeutic strategies based on antioxidant and anti-inflammatory compounds would involve generalized anti-aging effects also benefiting endothelial cells. MicroRNA (miRNAs) - single-stranded, non-coding RNAs expressed by all living cells and involved in the epigenetic modulation of all transcriptional programs - may constitute an innovative, valuable tool to detect and target senescent endothelial cells and to devise treatments that can slow down the pro-inflammatory program activated in senescent endothelial cells.
authors.forename: Francesco
authors.initials: F
authors.lastname: Prattichizzo
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Bonafè
authors.forename: Artan
authors.initials: A
authors.lastname: Ceka
authors.forename: Angelica
authors.initials: A
authors.lastname: Giuliani
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Rippo
authors.forename: Massimo
authors.initials: M
authors.lastname: Re
authors.forename: Roberto
authors.initials: R
authors.lastname: Antonicelli
authors.forename: Antonio Domenico
authors.initials: AD
authors.lastname: Procopio
authors.affiliation: Department of Clinical and Molecular Sciences (DISCLIMO), Università Politecnica delle Marche, Ancona, Via Tronto 10/A - 60020 Ancona, Italy. f.olivieri@univpm.it.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Olivieri
mesh_terms: D000375:Aging / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D016922:Cellular Senescence / Q000187:drug effects; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005819:Genetic Markers; D035683:MicroRNAs