title: Development of an AIDS vaccine using Sendai virus vectors.
abstract: Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection.
authors.affiliation: AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.affiliation: AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan; The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address: tmatano@nih.go.jp.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matano
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002986:Clinical Trials as Topic; D005822:Genetic Vectors; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D008251:Macaca; D023421:Models, Animal; D018449:SAIDS Vaccines / Q000276:immunology; D029082:Sendai virus / Q000235:genetics*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D014614:Vaccines, Synthetic
chemical_list: D016915:AIDS Vaccines; D000914:Antibodies, Viral; D018449:SAIDS Vaccines; D014614:Vaccines, Synthetic
keywords: AIDS vaccine; HIV; SIV; Sendai virus vector