title: One-pot directed alkylation/deprotection strategy for the synthesis of substituted pyrrole[3,4-d]pyridazinones.
abstract: In the course of an SAR study of pyrrole[3,4-d]pyridazinones we optimized conditions for a one pot directed lithiation / alkylation reaction that also promotedin situcleavage of a Boc-protecting group on the pyrrole ring. The efficiency of the process allowed access to a number of substituted analogues of interest as possible antitumor agents.
authors.affiliation: The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33418, http://www.scripps.edu/research/faculty/bannister.
authors.forename: Reji N
authors.initials: RN
authors.lastname: Nair
authors.affiliation: The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33418, http://www.scripps.edu/research/faculty/bannister.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Bannister
keywords: antitumour agents; fused-ring systems; halogenation; heterocycles; lithiation; metalation; protecting groups