title: Association Between Growth of Geographic Atrophy and the Complement Factor I Locus.
abstract: The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P ≥ .72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Yehoshua
authors.forename: Carlos Alexandre
authors.initials: CA
authors.lastname: de Amorim Garcia Filho
authors.forename: Renata Portella
authors.initials: RP
authors.lastname: Nunes
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gregori
authors.forename: Fernando M
authors.initials: FM
authors.lastname: Penha
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Moshfeghi
authors.forename: Hongrong
authors.initials: H
authors.lastname: Luo
authors.forename: Zhang
authors.initials: Z
authors.lastname: Kang
authors.forename: SriniVas
authors.initials: S
authors.lastname: Sadda
authors.forename: William
authors.initials: W
authors.lastname: Feuer
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenfeld
mesh_terms: D003175:Complement C2; D003176:Complement C3; D017242:Complement Factor H / Q000235:genetics; D017244:Complement Factor I / Q000235:genetics*; D005451:Fluorescein Angiography; D060005:Genotyping Techniques; D057092:Geographic Atrophy / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D041623:Tomography, Optical Coherence
chemical_list: C493495:CFH protein, human; D003175:Complement C2; D003176:Complement C3; D017242:Complement Factor H; C493611:CFI protein, human; D017244:Complement Factor I