title: Total synthesis of astrosterioside A, an anti-inflammatory asterosaponin.
abstract: Astrosterioside A, a sulfated steroidal hexasaccharide isolated from starfish Astropecten monacanthus showing potent anti-inflammatory activity, was synthesized in a convergent linear sequence of 24 steps and in 6.8% overall yield from adrenosterone.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China. byu@mail.sioc.ac.cn.
authors.forename: Yuanwei
authors.initials: Y
authors.lastname: Dai
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D000736:Androstenes / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002240:Carbohydrate Sequence; D060326:Chemistry Techniques, Synthetic; D012503:Saponins / Q000138:chemical synthesis*
chemical_list: D000736:Androstenes; D000893:Anti-Inflammatory Agents; D012503:Saponins; C584992:astrosterioside A; C011657:adrenosterone