title: Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats.
abstract: The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats. The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5, 5, and 10 mg·kg(-1) were quantified by HPLC. The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mg·kg(-1) were also analyzed. The plasma pharmacokinetic parameters at the three doses were as follows: t(1/2), (86.23 ± 6.83), (72.66 ± 4.10) and (71.20 ± 2.90) min; C0, (11.10 ± 1.47), (23.67 ± 1.24) and (39.17 ± 3.90) μg·mL(-1); and AUC(0→∞), (1 240.90 ± 129.14), (2 273.84 ± 132.47) and (3 516.4 ± 403.37) min·μg·mL(-1), respectively. The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver, heart and kidneys.
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Yu-Shuai
authors.initials: YS
authors.lastname: Peng
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Li-Jia
authors.initials: LJ
authors.lastname: Liu
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Can
authors.initials: C
authors.lastname: Zhao
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. Electronic address: wangrufeng@tsinghua.org.cn.
authors.forename: Ru-Feng
authors.initials: RF
authors.lastname: Wang
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010936:Plant Extracts / Q000378:metabolism / Q000493:pharmacokinetics*; D029626:Ranunculaceae / Q000737:chemistry*; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D010936:Plant Extracts; C009333:veratric acid; D014641:Vanillic Acid
keywords: Pharmacokinetics; Tissue distribution; Veratric acid