title: Disruptions in Resting State Functional Connectivity and Cerebral Blood Flow in Mild Traumatic Brain Injury Patients.
abstract: Mild traumatic brain injury (mTBI) is often occult to conventional imaging techniques. However, there is growing evidence that mTBI patients who lack evidence of structural intracranial injury may develop post-concussive syndrome (PCS). We investigated longitudinal alterations in resting state functional connectivity (rs-FC) in brain networks in a population of 28 patients compared to 28 matched control participants. Rs-FC and cerebral blood flow (CBF) within the nodes of the Default Mode Network (DMN) and Task Positive Network (TPN) were assessed at three time points including acute, sub-acute, and chronic stages following mTBI. Participants received the Automated Neuropsychological Assessment Metrics (ANAM) to assess cognitive performance. Main findings indicate that despite normalized cognitive performance, chronic mTBI patients demonstrate increased rs-FC between the DMN and regions associated with the salience network (SN) and TPN compared to the control populations, as well as reduced strength of rs-FC within the DMN at the acute stage of injury. In addition, chronic mTBI patients demonstrate an imbalance in the ratio of CBF between nodes of the DMN and TPN. Furthermore, preliminary exploratory analysis suggests that compared to those without chronic PCS, patients with chronic PCS reveal an imbalance in the ratio of CBF between the DMN nodes and TPN nodes across multiple stages of recovery. Findings suggest that the altered network perfusion with the associated changes in rs-FC may be a possible predictor of which mTBI patients will develop chronic PCS.
authors.affiliation: Magnetic Resonance Research Center, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Chandler
authors.initials: C
authors.lastname: Sours
authors.affiliation: Magnetic Resonance Research Center, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zhuo
authors.affiliation: Magnetic Resonance Research Center, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Steven
authors.initials: S
authors.lastname: Roys
authors.affiliation: Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Kathirkamanthan
authors.initials: K
authors.lastname: Shanmuganathan
authors.affiliation: Magnetic Resonance Research Center, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Rao P
authors.initials: RP
authors.lastname: Gullapalli
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000503:physiopathology* / Q000523:psychology; D002560:Cerebrovascular Circulation; D003072:Cognition Disorders / Q000209:etiology; D063132:Connectome; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009415:Nerve Net / Q000098:blood supply / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011446:Prospective Studies; D055815:Young Adult