title: Palladium-Catalyzed Synthesis of Phenanthridine/Benzoxazine-Fused Quinazolinones by Intramolecular C-H Bond Activation.
abstract: A highly efficient synthesis of phenanthridine/benzoxazine-fused quinazolinones by ligand-free palladium-catalyzed intramolecular C-H bond activation under mild conditions has been developed. The C-C coupling provides the corresponding N-fused polycyclic heterocycles in good to excellent yields and with wide functional group tolerance.
authors.affiliation: Division of Medicinal and Process Chemistry, CSIR-Central Drug, Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031 (India), Fax:(+91) 522-2623405, -2623938.
authors.forename: Puneet K
authors.initials: PK
authors.lastname: Gupta
authors.affiliation: Division of Medicinal and Process Chemistry, CSIR-Central Drug, Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031 (India), Fax:(+91) 522-2623405, -2623938.
authors.forename: Nisha
authors.initials: N
authors.lastname: Yadav
authors.affiliation: Division of Medicinal and Process Chemistry, CSIR-Central Drug, Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031 (India), Fax:(+91) 522-2623405, -2623938.
authors.forename: Subodh
authors.initials: S
authors.lastname: Jaiswal
authors.affiliation: Division of Medicinal and Process Chemistry, CSIR-Central Drug, Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031 (India), Fax:(+91) 522-2623405, -2623938.
authors.forename: Mohd
authors.initials: M
authors.lastname: Asad
authors.affiliation: Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031 (India).
authors.forename: Ruchir
authors.initials: R
authors.lastname: Kant
authors.affiliation: Division of Medicinal and Process Chemistry, CSIR-Central Drug, Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031 (India), Fax:(+91) 522-2623405, -2623938. kanchan_hajela@cdri.res.in.
authors.forename: Kanchan
authors.initials: K
authors.lastname: Hajela
keywords: CC coupling; CH activation; fused-ring systems; heterocycles; oxidation