title: Influence of dioxin on the daily variation of insulin sensitivity in mice.
abstract: To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. TCDD elevated plasma TNF-α, and the value was significantly higher during an active period than during a rest period. These data suggest that TCDD blunts insulin sensitivity, mainly during an active period. Higher elevation in plasma TNF-α during an active period might be involved in this phenomenon.
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Takuma
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ushijima
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kumazaki
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ando
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan. Electronic address: akiofuji@jichi.ac.jp.
authors.forename: Akio
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002940:Circadian Rhythm / Q000187:drug effects*; D004785:Environmental Pollutants / Q000008:administration & dosage* / Q000494:pharmacology; D005951:Glucose Tolerance Test; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D001786:Blood Glucose; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D014409:Tumor Necrosis Factor-alpha
keywords: Chronotoxicology; Dioxin; Insulin sensitivity; TNF-α