title: Expression regulation and targeting of the peroxisome proliferator-activated receptor γ following electrically-induced status epilepticus.
abstract: The neuroprotective and anti-inflammatory effects of the peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone are of particular interest for disease-modifying and antiepileptogenic approaches. We studied the expression of PPARγ and the impact of rosiglitazone on the consequences of status epilepticus (SE) in a rat post-SE model. Immunohistochemical analysis revealed a selective overexpression of PPARγ in the piriform cortex of rats with spontaneous seizures. Rosiglitazone administration initiated following SE failed to exert relevant effects on the development of spontaneous seizures and neuronal cell loss. Whereas spatial learning in the Morris water maze was delayed in SE animals with vehicle administration, the learning curve of rosiglitazone-treated SE rats showed no significant difference to that of controls. The study provides first evidence arguing against a robust antiepileptogenic effect. However, the findings in the spatial learning paradigm indicate disease-modifying effects.
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Boes
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.
authors.forename: Vera
authors.initials: V
authors.lastname: Russmann
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Ongerth
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Licko
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.
authors.forename: Josephine D
authors.initials: JD
authors.lastname: Salvamoser
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Siegl
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany. Electronic address: potschka@pharmtox.vetmed.uni-muenchen.de.
authors.forename: Heidrun
authors.initials: H
authors.lastname: Potschka
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D004558:Electric Stimulation; D005260:Female; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D018782:Maze Learning; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D047495:PPAR gamma / Q000819:agonists / Q000378:metabolism*; D010296:Parietal Lobe / Q000187:drug effects / Q000473:pathology; D066195:Piriform Cortex / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D017207:Rats, Sprague-Dawley; D000077154:Rosiglitazone; D012640:Seizures / Q000503:physiopathology; D065853:Spatial Learning; D013226:Status Epilepticus / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D045162:Thiazolidinediones / Q000494:pharmacology
chemical_list: D047495:PPAR gamma; D045162:Thiazolidinediones; D000077154:Rosiglitazone
keywords: Epileptogenesis; Inflammation; Learning; PPARγ; Rosiglitazone