title: Voluntary Exercise Protects Heart from Oxidative Stress in Diabetic Rats.
abstract: OBJECTIVE
  Oxidative stress plays a key role in the onset and development of diabetes complications. In this study, we evaluated whether voluntary exercise could alleviate oxidative stress in the heart and blood of streptozotocin - induced diabetic rats.
  
  
  METHODS
  28 male Wistar rats were randomly divided into four groups (n=7): control, exercise, diabetes and exercise + diabetes. Diabetes was induced by injection of streptozotocin in male rats. Rats in the trained groups were subjected to voluntary running wheel exercise for 6 weeks. At the end of six weeks blood and heart tissue samples were collected and used for determination of antioxidant enzymes (including SOD, GPX and CAT activities) and MDA level.
  
  
  RESULTS
  Exercise significantly reduced MDA levels both in the heart tissue (p<0.01) and blood samples (p<0.05). In addition, exercise significantly increased SOD (p<0.05), GPX (p<0.001) and CAT (p<0.05) in the heart tissue. Voluntary exercise also significantly increased SOD (p<0.01), GPX (p<0.05) and CAT (p<0.001) in the blood.
  
  
  CONCLUSIONS
  Voluntary exercise diminishes the MDA level in blood and heart tissue of diabetic rats. It also accentuates activities of SOD, GPX and CAT. Therefore, it may be considered a useful tool for the reduction of oxidative stress in diabetes.
authors.affiliation: Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Naderi
authors.affiliation: Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Gisou
authors.initials: G
authors.lastname: Mohaddes
authors.affiliation: Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Mohammadi
authors.affiliation: Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Rana
authors.initials: R
authors.lastname: Ghaznavi
authors.affiliation: Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Rafigheh
authors.initials: R
authors.lastname: Ghyasi
authors.affiliation: Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Amir Mansour
authors.initials: AM
authors.lastname: Vatankhah
keywords: Diabetes; Heart; Oxidative Stress; Voluntary running wheel