title: Brown tumours of the tibia and second metacarpal bone in a woman with severe vitamin D deficiency.
abstract: Brown tumours caused by vitamin D deficiency are rare. Most cases are caused by primary hyperparathyroidism, and are rarely caused by secondary hyperparathyroidism in cases of renal failure. We present a case of Brown tumours of the tibia and second metacarpal bone in a 50-year-old woman who had a low dietary intake of vitamin D and had worn a veil for most of her adult life. The Brown tumours were caused by vitamin D deficiency and secondary hyperparathyroidism. The patient improved on treatment with vitamin D3 and calcium supplements. This is a rare case and the first, to our knowledge, with a Brown tumour of the tibia caused by vitamin D deficiency due to decreased dietary intake and decreased exposure to sunlight. The course of treatment and investigations of the patient are described.
authors.affiliation: Department of Medicine, Sana'a University, Sana'a, Yemen.
authors.forename: Butheinah A
authors.identifier: http://orcid.org/0000-0002-0520-8164
authors.initials: BA
authors.lastname: Al-Sharafi
authors.affiliation: Department of Medicine, University of Science and Technology Hospital, Sana'a, Yemen.
authors.forename: Shafiq A
authors.initials: SA
authors.lastname: Al-Imad
authors.affiliation: Department of Pathology, University of Science and Technology Hospital, Sana'a, Yemen.
authors.forename: Amani M
authors.initials: AM
authors.lastname: Shamshair
authors.affiliation: Department of Radiology, University of Science and Technology Hospital, Sana'a, Yemen.
authors.forename: Derhim H
authors.initials: DH
authors.lastname: Al-Faqeeh
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy / Q000209:etiology*; D002136:Calcium, Dietary / Q000627:therapeutic use; D002762:Cholecalciferol / Q000008:administration & dosage / Q000627:therapeutic use; D003020:Clothing; D004032:Diet; D005260:Female; D006225:Hand; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications*; D007866:Leg; D050279:Metacarpal Bones / Q000473:pathology*; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000188:drug therapy / Q000209:etiology*; D013472:Sunlight; D013977:Tibia / Q000473:pathology*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy
chemical_list: D002136:Calcium, Dietary; D002762:Cholecalciferol