title: A new method to predict anatomical outcome after idiopathic macular hole surgery.
abstract: OBJECTIVE
  To investigate whether a new macular hole closure index (MHCI) could predict anatomic outcome of macular hole surgery.
  
  
  METHODS
  A vitrectomy with internal limiting membrane peeling, air-fluid exchange, and gas tamponade were performed on all patients. The postoperative anatomic status of the macular hole was defined by spectral-domain OCT. MHCI was calculated as (M+N)/BASE based on the preoperative OCT status. M and N were the curve lengths of the detached photoreceptor arms, and BASE was the length of the retinal pigment epithelial layer (RPE layer) detaching from the photoreceptors. Postoperative anatomical outcomes were divided into three grades: A (bridge-like closure), B (good closure), and C (poor closure or no closure). Correlation analysis was performed between anatomical outcomes and MHCI. Receiver operating characteristic (ROC) curves were derived for MHCI, indicating good model discrimination. ROC curves were also assessed by the area under the curve, and cut-offs were calculated. Other predictive parameters reported previously, which included the MH minimum, the MH height, the macular hole index (MHI), the diameter hole index (DHI), and the tractional hole index (THI) had been compared as well.
  
  
  RESULTS
  MHCI correlated significantly with postoperative anatomical outcomes (r = 0.543, p = 0.000), but other predictive parameters did not. The areas under the curves indicated that MHCI could be used as an effective predictor of anatomical outcome. Cut-off values of 0.7 and 1.0 were obtained for MHCI from ROC curve analysis. MHCI demonstrated a better predictive effect than other parameters, both in the correlation analysis and ROC analysis.
  
  
  CONCLUSIONS
  MHCI could be an easily measured and accurate predictive index for postoperative anatomical outcomes.
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China.|Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China.|Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
authors.forename: Chongya
authors.initials: C
authors.lastname: Dong
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China.|Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Song
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China.|Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China.|Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China.|Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China.|Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China. zhaomingwei@medmail.com.cn.|Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. zhaomingwei@medmail.com.cn.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Zhao
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000601:surgery; D058450:Endotamponade; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016684:Prone Position; D012372:ROC Curve; D012160:Retina / Q000473:pathology*; D012167:Retinal Perforations / Q000175:diagnosis* / Q000601:surgery*; D012189:Retrospective Studies; D013459:Sulfur Hexafluoride / Q000008:administration & dosage*; D041623:Tomography, Optical Coherence; D014821:Vitrectomy
chemical_list: D013459:Sulfur Hexafluoride
keywords: Anatomical outcome; Idiopathic macular hole; Optical coherence tomography; Prediction; Vitrectomy