title: Preventive Migraine Treatment.
abstract: OBJECTIVE
  This article reviews the evidence base for the preventive treatment of migraine.
  
  
  RESULTS
  Evidence-based guidelines for the preventive treatment of migraine have recently been published by the American Academy of Neurology (AAN) and the Canadian Headache Society (CHS), providing valuable guidance for clinicians. Strong evidence exists to support the use of metoprolol, timolol, propranolol, divalproex sodium, sodium valproate, and topiramate for migraine prevention, according to the AAN. Based on best available evidence, adverse event profile, and expert consensus, topiramate, propranolol, nadolol, metoprolol, amitriptyline, gabapentin, candesartan, Petasites (butterbur), riboflavin, coenzyme Q10, and magnesium citrate received a strong recommendation for use from the CHS.
  
  
  CONCLUSIONS
  Migraine preventive drug treatments are underutilized in clinical practice. Principles of preventive treatment are important to improve compliance, minimize side effects, and improve patient outcomes. Choice of preventive treatment of migraine should be based on the presence of comorbid and coexistent illness, patient preference, reproductive potential and planning, and best available evidence.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Silberstein
mesh_terms: D019317:Evidence-Based Medicine / Q000379:methods* / Q000592:standards; D006801:Humans; D008881:Migraine Disorders / Q000517:prevention & control*