title: Non-O blood groups can be a prognostic marker of in-hospital and long-term major adverse cardiovascular events in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention.
abstract: BACKGROUND
  Recent studies have suggested ABO blood type locus as an inherited predictor of thrombosis, cardiovascular risk factors, myocardial infarction. However, data is scarce about the impact of non-O blood groups on prognosis in patients with ST-elevation myocardial infarction (STEMI). Therefore, we aimed to evaluate the prognostic importance of non-O blood groups in patients with STEMI undergoing primary percutaneous coronary intervention (pPCI) METHODS: 1835 consecutive patients who were admitted with acute STEMI between 2010 and 2015 were included and followed-up for a median of 35.6months.
  
  
  RESULTS
  The prevalence of hyperlipidemia, total cholesterol, LDL, peak CKMB and no-reflow as well as hospitalization duration were higher in patients with non-O blood groups. Gensini score did not differ between groups. During the in-hospital and long-term follow-up period, MACE, the prevalence of stent thrombosis, non-fatal MI, and mortality were higher in non-O blood groups. In multivariate logistic regression analysis, non-0 blood groups were demonstrated to be independent predictors of in-hospital (OR:2.085 %CI: 1.328-3.274 p=0.001) and long term MACE (OR:2.257 %CI: 1.325-3.759 p<0.001). Kaplan-Meier analysis according to the long-term MACE free survival revealed a higher occurrence of MACE in non-O blood group compared with O blood group (p<0.001, Chi-square: 22.810).
  
  
  CONCLUSIONS
  Non-O blood groups were determined to be significant prognostic indicators of short- and long-term cardiovascular adverse events and mortality in patients with STEMI undergoing pPCI. In conjunction with other prognostic factors, evaluation of this parameter may improve the risk categorization and tailoring the individual therapy and follow-up in STEMI patient population.
authors.affiliation: Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
authors.forename: Mehmet Serkan
authors.initials: MS
authors.lastname: Cetin
authors.affiliation: Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey. Electronic address: dr.elifhande@gmail.com.
authors.forename: Elif Hande
authors.initials: EH
authors.lastname: Ozcan Cetin
authors.affiliation: Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
authors.affiliation: Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Topaloglu
authors.affiliation: Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temizhan
authors.affiliation: Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
authors.forename: Halil Lutfi
authors.initials: HL
authors.lastname: Kisacik
authors.affiliation: Türkiye Yuksek Ihtisas Education and Research Hospital, Cardiology Department, Ankara Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydogdu
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015984:Causality; D015897:Comorbidity; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality* / Q000601:surgery*; D062645:Percutaneous Coronary Intervention / Q000401:mortality*; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D013812:Therapeutics; D013927:Thrombosis / Q000097:blood* / Q000401:mortality*; D014421:Turkey / Q000453:epidemiology
chemical_list: D000017:ABO Blood-Group System; D015415:Biomarkers
keywords: ABO blood groups; Gensini; MACE; ST Elevation Myocardial Infarction; thrombosis