title: Excessive weight gain during pregnancy and risk of macrosomia: a meta-analysis.
abstract: OBJECTIVE
  This meta-analysis aimed to estimate the relation between excessive gestational weight gain and macrosomia.
  
  
  METHODS
  We performed a meta-analysis by searching PubMed, EMBASE and the Cochrane library for English-language literature from inception to 1 October 2014. Studies assessing the relationship between excessive gestational weight gain and macrosomia were included. Characteristics including study design, country, sample size, definition of macrosomia, adjusted odds ratios, CIs and adjustment factors were extracted independently by two reviewers. Summary odds ratios were calculated by using a random-effects model meta-analysis.
  
  
  RESULTS
  15 relevant articles were eligible for the meta-analysis. Incorporated by random-effect model before the heterogeneity tests, the value of OR was 2.35 (95 % CI: 1.95, 2.85). Stratified analysis showed no differences regarding different study design, definition of macrosomia and location of study. There was no indication of a publication bias either from the result of Egger's test (P = 0.572) or Begg's test (P = 0.572).
  
  
  CONCLUSIONS
  Our meta-analysis indicated that excessive gestational weight gain might increase the risk of macrosomia.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China.
authors.forename: Chaoqing
authors.initials: C
authors.lastname: Tian
authors.affiliation: Department of Obstetrics and Gynecology, Affiliated Provincial Hospital of Anhui Medical University, Hefei, China.
authors.forename: Chengwen
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China.
authors.forename: Xiujie
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China.
authors.forename: Fengyun
authors.initials: F
authors.lastname: Qin
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China. huchuanlai@ahmu.edu.cn.
authors.forename: Chuanlai
authors.initials: C
authors.lastname: Hu
mesh_terms: D001724:Birth Weight; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012307:Risk Factors; D015430:Weight Gain
keywords: Case–control study; Cohort study; Gestational weight gain; Macrosomia; Meta-analysis