title: [Cutaneous extramedullary hematopoiesis associated with myelodysplastic/myeloproliferative neoplasm, unclassifiable].
abstract: Cutaneous extramedullary hematopoiesis has been reported in a small number of patients with myelofibrosis. A 79-year-old male with JAK2V617F-positive myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS-MPN-U), presented with multiple skin lesions. The skin lesions were papulonodular, reddish brown, and elastic hard on palpation. Based on a lesion biopsy, cutaneous extramedullary hematopoiesis associated with MDS/MPN-U was diagnosed. He died four months later due to exacerbation of MDS/MPN-U. Cutaneous invasion might be associated with progressive disease and a poor prognosis for MDS/MPN-U, as it is for myelofibrosis.
authors.affiliation: Department of Hematology, Osaka City General Hospital.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Mirei
authors.initials: M
authors.lastname: Horiuchi
authors.forename: Hideya
authors.initials: H
authors.lastname: Ueda
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Hagihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanashima
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nakao
authors.forename: Chika
authors.initials: C
authors.lastname: Hirata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamane
mesh_terms: D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D008297:Male; D054437:Myelodysplastic-Myeloproliferative Diseases / Q000150:complications*; D009361:Neoplasm Invasiveness; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology*