title: The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain.
abstract: Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Rush University Medical Center, 1611 W. Harrison St, Suite 510, Chicago, IL, 60612, USA.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Miller
authors.forename: Phuong B
authors.initials: PB
authors.lastname: Tran
authors.forename: Alia M
authors.initials: AM
authors.lastname: Obeidat
authors.forename: Padmanabhan
authors.initials: P
authors.lastname: Raghu
authors.forename: Shingo
authors.initials: S
authors.lastname: Ishihara
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Miller
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Malfait
mesh_terms: D059350:Chronic Pain / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D009619:Nociceptors / Q000502:physiology*; D020370:Osteoarthritis, Knee / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy