title: Neonatal Platelet Function.
abstract: Similarly to the development of the plasma coagulation system, which matures during the early weeks and months of life, age-dependent mechanisms and developmental changes influence platelet production and function in neonates. Platelet function testing on cord blood and peripheral blood demonstrates a generalized platelet hyporeactivity, during the first days of life. This reactivity reaches normal adult levels between the fifth and ninth day of life. The persistence of hyporeactivity after the tenth day of life might indeed suggest a platelet disorder.
authors.affiliation: Neonatal Intensive Care Unit, Di Venere Hospital, Via Ospedale Di Venere n.1, Bari 70131, Italy. Electronic address: a.delvecchio@asl.bari.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Del Vecchio
authors.affiliation: Neonatology and Neonatal Intensive Care Unit, Children's Hospital of Brescia, Brescia, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Motta
authors.affiliation: Neonatal Intensive Care Unit, Division of Neonatology, Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D005312:Fetal Blood / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D010979:Platelet Function Tests
keywords: Megakaryocytes; Neonatal hemostasis; Platelet hyporeactivity; Platelets; Primary hemostasis; Thrombocytopoiesis