title: Quality of life improvement in patients with Hashimoto thyroiditis and other goiters after surgery: A prospective cohort study.
abstract: BACKGROUND
  Hashimoto thyroiditis (HT) and other benign goiters (BG) might influence patients' quality of life (QoL). The objective of this study was to analyze influence of surgery on these patients' QoL.
  
  
  METHODS
  A prospective cohort study was conducted. The ThyPRO questionnaire was used in the QoL assessment.
  
  
  RESULTS
  The HT patients experienced significantly worse hypothyroid symptoms and sex life than the BG patients. The improvement in QoL in the BG patients was significant after surgery in all ThyPRO domains. In the HT patients, the improvement was significant in all but two domains, eye symptoms and cognitive impairment. The best improvement in both groups was in overall QoL. None of the patients developed permanent consequences.
  
  
  CONCLUSIONS
  The QoL of HT and BG patients is impaired and improves significantly after surgical treatment. Thyroidectomy should be considered as a treatment option in the HT patients more often as in the BG patients.
authors.affiliation: Faculty of Medicine, University of Belgrade, Center for Endocrine Surgery, Clinical Center of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia.
authors.forename: Vladan R
authors.initials: VR
authors.lastname: Zivaljevic
authors.affiliation: General Hospital Uzice, Health Centre Uzice, Milosa Obrenovica 17, 31000 Uzice, Serbia. Electronic address: bukvicbranka@gmail.com.
authors.forename: Branka R
authors.initials: BR
authors.lastname: Bukvic Bacotic
authors.affiliation: Institute for Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.
authors.forename: Sandra B
authors.initials: SB
authors.lastname: Sipetic
authors.affiliation: Institute of Medical Statistics and Infomratics, Faculty of Medicine, University of Belgrade, Dr Subotica Street 8, 11000 Belgrade, Serbia.
authors.forename: Dejana M
authors.initials: DM
authors.lastname: Stanisavljevic
authors.affiliation: Institute for Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.
authors.forename: Jadranka M
authors.initials: JM
authors.lastname: Maksimovic
authors.affiliation: Faculty of Medicine, University of Belgrade, Center for Endocrine Surgery, Clinical Center of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia.
authors.forename: Aleksandar D
authors.initials: AD
authors.lastname: Diklic
authors.affiliation: Faculty of Medicine, University of Belgrade, Center for Endocrine Surgery, Clinical Center of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia.
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Paunovic
mesh_terms: D015331:Cohort Studies; D005260:Female; D006042:Goiter / Q000523:psychology* / Q000601:surgery*; D050031:Hashimoto Disease / Q000523:psychology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D013965:Thyroidectomy
keywords: Benign goiter; Hashimoto thyroiditis; Quality of life; Thyroidectomy