title: Proteomics in gastric cancer research: Benefits and challenges.
abstract: Among various cancers, gastric cancer (GC) exhibits relatively high morbidity and mortality rate worldwide. The lack of effective methods in early detection and diagnosis, and immediate therapies makes treating such disease a challenge for both clinicians and oncologists. Proteomics has emerged as a promising technology platform for rationally identifying biomarkers and novel therapeutic targets for GC, as well as discovering underlying mechanisms of carcinogenesis. Its application has greatly benefited mechanistic studies of this disease. This review will demonstrate the applications of proteomic technology in GC research. The advantages and shortcomings of this technology, as reflected by current studies, will also be discussed to improve and expand its application in the field of cancer research.
authors.affiliation: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Li
authors.affiliation: Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, P. R. China.
authors.forename: Robert Z
authors.initials: RZ
authors.lastname: Qi
authors.affiliation: Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, P. R. China.
authors.forename: Gary Kar Ho
authors.initials: GK
authors.lastname: Ng
authors.affiliation: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China. dxie@sibs.ac.cn.
authors.forename: Dong
authors.initials: D
authors.lastname: Xie
keywords: Gastric cancer; Proteomic application