title: Antrocarines A-F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum.
abstract: During a study on the chemistry and biological activity of Antrocaryon klaineanum Pierre, six new sterols including 4,24(28)-ergostadiene-6α,7α-diol (1), 6α-methoxy-4,24(28)-ergostadiene-7α,20S-diol (2), 6α-methoxy-4,24(28)-ergostadien-7α-ol (3), 20S-hydroxy-24(28)-ergosten-3-one (4), 7α-hydroxy-4,24(28)-ergostadien-3-one (5), and 24(28)-ergostene-3β,6α-diol (6) were characterized by physical and spectroscopic means. The known steroids 7 and 8 were also isolated. The crude extract and the isolated compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum. Compounds 2, 3, and 8 showed potent activity while that of the crude extract was moderate.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, The University of Yaounde-1, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Pascal D
authors.initials: PD
authors.lastname: Douanla
authors.affiliation: Department of Organic Chemistry, Faculty of Science, The University of Yaounde-1, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Turibio Kuiate
authors.initials: TK
authors.lastname: Tabopda
authors.affiliation: Laboratory of Phytochemistry, Institute of Medical Research and Medicinal Plant Studies, (IMPM), P.O. Box 6163, Yaounde, Cameroon.
authors.forename: Alembert T
authors.initials: AT
authors.lastname: Tchinda
authors.affiliation: Université de Liège, Laboratoire de Pharmacognosie, Centre Interfacultaire de Recherche sur le médicament (CIRM), Département de Pharmacie, Université de Liège, B36, B-4000 Liège, Belgium.
authors.forename: Ewa
authors.initials: E
authors.lastname: Cieckiewicz
authors.affiliation: Université de Liège, Laboratoire de Pharmacognosie, Centre Interfacultaire de Recherche sur le médicament (CIRM), Département de Pharmacie, Université de Liège, B36, B-4000 Liège, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Frédérich
authors.affiliation: Department of Biochemistry, Faculty of Science, The University of Yaounde-1, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Fabrice Fekam
authors.initials: FF
authors.lastname: Boyom
authors.affiliation: Laboratory of Phytochemistry, Institute of Medical Research and Medicinal Plant Studies, (IMPM), P.O. Box 6163, Yaounde, Cameroon.
authors.forename: Nole
authors.initials: N
authors.lastname: Tsabang
authors.affiliation: Department of Chemistry, University of Botswana, Private Bag 00704, Gaborone, Botswana.
authors.forename: Samuel
authors.initials: S
authors.lastname: Yeboah
authors.affiliation: Department of Organic Chemistry, Faculty of Science, The University of Yaounde-1, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Augustin E
authors.initials: AE
authors.lastname: Nkengfack
authors.affiliation: Department of Organic Chemistry, Faculty of Science, The University of Yaounde-1, P.O. Box 812, Yaounde, Cameroon. Electronic address: mhkenmogne@yahoo.fr.
authors.forename: Marguerite Hortence K
authors.initials: MHK
authors.lastname: Tchuendem
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004875:Ergosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C000608331:6-methoxy-4,24(28)-ergostadien-7-ol; C000608330:6-methoxy-4,24(28)-ergostadiene-7,20-diol; D000962:Antimalarials; D010936:Plant Extracts; D013256:Steroids; C015190:ergostane; D004875:Ergosterol
keywords: Anacardiaceae; Antiplasmodial activities; Antrocaryon klaineanum; Ergostane steroids