title: Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network.
abstract: Molecular epidemiology leverages genetic information to study the risk factors that affect the frequency and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second, we describe and compare different parasite genotyping methods commonly used in malaria epidemiology and population genetics. Finally, we discuss potential applications of molecular epidemiological tools and methods toward malaria control and elimination efforts.
authors.forename: Ananias A
authors.initials: AA
authors.lastname: Escalante
authors.forename: Marcelo U
authors.initials: MU
authors.lastname: Ferreira
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Vinetz
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Volkman
authors.forename: Liwang
authors.initials: L
authors.lastname: Cui
authors.forename: Dionicia
authors.initials: D
authors.lastname: Gamboa
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Krogstad
authors.forename: Alyssa E
authors.initials: AE
authors.lastname: Barry
authors.forename: Jane M
authors.initials: JM
authors.lastname: Carlton
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: van Eijk
authors.forename: Khageswar
authors.initials: K
authors.lastname: Pradhan
authors.forename: Ivo
authors.initials: I
authors.lastname: Mueller
authors.forename: Bryan
authors.initials: B
authors.lastname: Greenhouse
authors.forename: M Andreina
authors.initials: MA
authors.lastname: Pacheco
authors.forename: Andres F
authors.initials: AF
authors.lastname: Vallejo
authors.forename: Socrates
authors.initials: S
authors.lastname: Herrera
authors.forename: Ingrid
authors.initials: I
authors.lastname: Felger
mesh_terms: D051456:Gene Flow / Q000235:genetics; D005828:Genetics, Population; D060005:Genotyping Techniques; D006801:Humans; D007391:International Cooperation; D008288:Malaria / Q000453:epidemiology* / Q000235:genetics* / Q000517:prevention & control / Q000635:transmission; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000235:genetics; D016780:Malaria, Vivax / Q000453:epidemiology / Q000235:genetics; D017720:Molecular Epidemiology; D010961:Plasmodium / Q000235:genetics*; D010963:Plasmodium falciparum / Q000235:genetics; D010966:Plasmodium vivax / Q000235:genetics