title: Reaction monitoring using online vs tube NMR spectroscopy: seriously different results.
abstract: We report findings from the qualitative evaluation of nuclear magnetic resonance (NMR) reaction monitoring techniques of how each relates to the kinetic profile of a reaction process. The study highlights key reaction rate differences observed between the various NMR reaction monitoring methods investigated: online NMR, static NMR tubes, and periodic inversion of NMR tubes. The analysis of three reaction processes reveals that rates derived from NMR analysis are highly dependent on monitoring method. These findings indicate that users must be aware of the effect of their monitoring method upon the kinetic rate data derived from NMR analysis. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Analytical Research and Development, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT, 06340, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Foley
authors.affiliation: Analytical Research and Development, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT, 06340, USA.|Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, WI, 53706, USA.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Dunn
authors.affiliation: Analytical Research and Development, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT, 06340, USA.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Zell
keywords: NMR reaction monitoring; online NMR; reaction mechanism