title: Thrombocytopenic Purpura Associated with Dietary Supplements Containing Citrus Flavonoids.
abstract: We report a case of thrombocytopenic purpura associated with the intake of two dietary supplements containing mainly citrus flavonoids. This is the first case to be notified to the French Agency for Food, Environmental and Occupational Health Safety (ANSES). It addresses the importance of an accurate medication history interview for each patient.
authors.affiliation: Service de Médecine Interne et Maladies Vasculaires ; Centre Hospitalier Universitaire Angers, Angers, France.
authors.forename: Alaa
authors.initials: A
authors.lastname: Ghali
authors.affiliation: Centre Régional de Pharmacovigilance, Centre Hospitalier Universitaire Angers, Angers, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Bourneau-Martin
authors.affiliation: Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail, Maisons-Alfort, France.
authors.forename: Aymeric
authors.initials: A
authors.lastname: Dopter
authors.affiliation: Centre Régional de Pharmacovigilance, Centre Hospitalier Universitaire Angers, Angers, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Lainé-Cessac
authors.affiliation: Service de Médecine Interne et Maladies Vasculaires ; Centre Hospitalier Universitaire Angers, Angers, France.
authors.forename: Cristina
authors.initials: C
authors.lastname: Belizna
authors.affiliation: Service de Médecine Interne et Maladies Vasculaires ; Centre Hospitalier Universitaire Angers, Angers, France.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Urbanski
authors.affiliation: Service de Médecine Interne et Maladies Vasculaires ; Centre Hospitalier Universitaire Angers, Angers, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Lavigne
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D019440:Anti-Obesity Agents / Q000009:adverse effects*; D002957:Citrus / Q000737:chemistry*; D019587:Dietary Supplements / Q000009:adverse effects*; D044950:Flavanones / Q000009:adverse effects*; D047309:Flavones / Q000009:adverse effects*; D006569:Hesperidin / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000009:adverse effects*; D017713:Platelet Transfusion; D011696:Purpura, Thrombocytopenic / Q000139:chemically induced* / Q000628:therapy
chemical_list: D000276:Adjuvants, Immunologic; D000305:Adrenal Cortex Hormones; D019440:Anti-Obesity Agents; D044950:Flavanones; D047309:Flavones; D016756:Immunoglobulins, Intravenous; D004366:Nonprescription Drugs; D006569:Hesperidin; C059006:tangeretin; C005274:naringin; C546526:neohesperidin