title: Layered Double Hydroxide Assemblies with Controllable Drug Loading Capacity and Release Behavior as well as Stabilized Layer-by-Layer Polymer Multilayers.
abstract: A stable drug release system with magnetic targeting is essential in a drug delivery system. In the present work, layered double hydroxide assemblies stabilized by layer-by-layer polymer multilayers were prepared by alternative deposition of poly(allylamine hydrochloride) and poly(acrylic acid) species on composite particles of Fe3O4 and ZnAl-LDH and then covalent cross-linkage of the polymer multilayers by photosensitive cross-linker. The successful fabrication was recorded by Zeta potential and Fourier transform infrared spectrum measurements. The formed assemblies were stable in high pH solutions (pH > 7). The drug loading capacity and release behavior of the assemblies could be controlled by treatment with appropriate acidic solution, and were confirmed by loading and release of a simulated drug, methylene blue. The formed assemblies possessed enough saturated magnetic strength and were sensitive to external magnetic field which was essential for targeting drug delivery. The formed assemblies were multifunctional assemblies with great potential as drug delivery system.
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences , Beijing, 100083, China.
authors.forename: Fengzhu
authors.initials: F
authors.lastname: Lv
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences , Beijing, 100083, China.
authors.forename: Linan
authors.initials: L
authors.lastname: Xu
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences , Beijing, 100083, China.
authors.forename: Yihe
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences , Beijing, 100083, China.
authors.forename: Zilin
authors.initials: Z
authors.lastname: Meng
mesh_terms: D000143:Acids / Q000737:chemistry; D000535:Aluminum / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry; D006878:Hydroxides / Q000737:chemistry*; D060328:Magnetic Phenomena; D008970:Molecular Weight; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry
chemical_list: D000143:Acids; D005290:Ferric Compounds; D006878:Hydroxides; D011108:Polymers; C000499:ferric oxide; C031356:hydroxide ion; D000535:Aluminum; D015032:Zinc
keywords: Layered double hydroxide; controlled drug release; covalent stabilization; etching; layer-by-layer