title: Effect of Low Doses (5-40 cGy) of Gamma-irradiation on Lifespan and Stress-related Genes Expression Profile in Drosophila melanogaster.
abstract: Studying of the effects of low doses of γ-irradiation is a crucial issue in different areas of interest, from environmental safety and industrial monitoring to aerospace and medicine. The goal of this work is to identify changes of lifespan and expression stress-sensitive genes in Drosophila melanogaster, exposed to low doses of γ-irradiation (5-40 cGy) on the imaginal stage of development. Although some changes in life extensity in males were identified (the effect of hormesis after the exposure to 5, 10 and 40 cGy) as well as in females (the effect of hormesis after the exposure to 5 and 40 cGy), they were not caused by the organism "physiological" changes. This means that the observed changes in life expectancy are not related to the changes of organism physiological functions after the exposure to low doses of ionizing radiation. The identified changes in gene expression are not dose-dependent, there is not any proportionality between dose and its impact on expression. These results reflect nonlinear effects of low dose radiation and sex-specific radio-resistance of the postmitotic cell state of Drosophila melanogaster imago.
authors.affiliation: Laboratory of Post-Genomic Research, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Zhikrevetskaya
authors.affiliation: Laboratory of molecular radiobiology and gerontology, Institute of Biology, Komi Science Center of RAS, Syktyvkar, Russia.
authors.forename: Darya
authors.initials: D
authors.lastname: Peregudova
authors.affiliation: Laboratory of molecular radiobiology and gerontology, Institute of Biology, Komi Science Center of RAS, Syktyvkar, Russia.
authors.forename: Anton
authors.initials: A
authors.lastname: Danilov
authors.affiliation: Laboratory of molecular radiobiology and gerontology, Institute of Biology, Komi Science Center of RAS, Syktyvkar, Russia; Department of ecology, Syktyvkar State University, Syktyvkar, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Plyusnina
authors.affiliation: Laboratory of Post-Genomic Research, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: George
authors.initials: G
authors.lastname: Krasnov
authors.affiliation: Laboratory of Post-Genomic Research, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Dmitriev
authors.affiliation: Laboratory of Post-Genomic Research, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: Anna
authors.initials: A
authors.lastname: Kudryavtseva
authors.affiliation: Laboratory of molecular radiobiology and gerontology, Institute of Biology, Komi Science Center of RAS, Syktyvkar, Russia; Department of ecology, Syktyvkar State University, Syktyvkar, Russia.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Shaposhnikov
authors.affiliation: Laboratory of Post-Genomic Research, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Laboratory of molecular radiobiology and gerontology, Institute of Biology, Komi Science Center of RAS, Syktyvkar, Russia; Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, Russia; Department of ecology, Syktyvkar State University, Syktyvkar, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Moskalev
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D008136:Longevity / Q000528:radiation effects*; D008297:Male; D012313:RNA / Q000302:isolation & purification / Q000378:metabolism; D011839:Radiation, Ionizing; D060888:Real-Time Polymerase Chain Reaction; D059467:Transcriptome / Q000528:radiation effects*
chemical_list: D012313:RNA