title: Bioengineering for Organ Transplantation: Progress and Challenges.
abstract: Organ transplantation can offer a curative option for patients with end stage organ failure. Unfortunately the treatment is severely limited by the availability of donor organs. Organ bioengineering could provide a solution to the worldwide critical organ shortage. The majority of protocols to date have employed the use of decellularization-recellularization technology of naturally occurring tissues and organs with promising results in heart, lung, liver, pancreas, intestine and kidney engineering. Successful decellularization has provided researchers with suitable scaffolds to attempt cell reseeding. Future work will need to focus on the optimization of organ specific recellularization techniques before organ bioengineering can become clinically translatable. This review will examine the current progress in organ bioengineering and highlight future challenges in the field.
authors.affiliation: a Ashford and St Peter's Hospitals NHS Foundation Trust ; Chertsey, Surrey , United Kingdom.
authors.forename: Ted
authors.initials: T
authors.lastname: Welman
authors.affiliation: b Department of Cardiac Surgery ; Ludwig-Maximilians-Universtät München ; Munich , Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Michel
authors.affiliation: c Department of Plastic Surgery ; Addenbrooke's Hospital ; Cambridge , United Kingdom.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Segaren
authors.affiliation: d Division of Surgery and Cancer; Imperial College London ; London , United Kingdom.
authors.forename: Kumaran
authors.initials: K
authors.lastname: Shanmugarajah
mesh_terms: D000818:Animals; D061249:Batch Cell Culture Techniques / Q000639:trends*; D021522:Bioartificial Organs / Q000639:trends*; D001698:Biomedical Engineering / Q000639:trends*; D006801:Humans; D009924:Organ Culture Techniques / Q000639:trends*; D023822:Tissue Engineering / Q000639:trends*; D054457:Tissue Scaffolds / Q000639:trends*
keywords: bioengineering; decellularization; organ transplantation; recellularization; regenerative medicine