title: Comparative Study on the Effects of Ceftriaxone and Monocytes on Recovery after Spinal Cord Injury in Rat.
abstract: OBJECTIVE
  Comparison between the efficacy of ceftriaxone and monocytes on improvement of neuron protection and functional recovery after spinal cord injury (SCI) in rat.
  
  
  METHODS
  Rats were randomly divided into three groups of ten. Spinal cord injury was performed on rats under general anesthesia using the weight dropping method. Ceftriaxone was injected intraperitoneally 200 mg/kg/day for seven days after SCI. Monocytes were injected 2 × 105 cells 4 days after SCI. Hind limb motor function was assessed using the Basso, Beattie and Bresnahan (BBB) scale. Corticospinal tract (CST) axons were traced by injection of biotin dextran amine (BDA) into the sensorimotor cortex.
  
  
  RESULTS
  There were statistically significant differences in BBB scores in ceftriaxone in comparison to both monocytes receiving and control groups. On the other hand there were statistically significant differences in axon counting in both ceftriaxone and monocytes receiving groups in comparison to control group.
  
  
  CONCLUSIONS
  Our findings suggest that ceftriaxone improves functional recovery more effective than monocytes in rats after SCI. These results are from an experimental model and validation is required for further investigation.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Tajkey
authors.affiliation: Department of Genetics and Molecular Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Biglari
authors.affiliation: Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Bohlol
authors.initials: B
authors.lastname: Habibi Asl
authors.affiliation: Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ramazani
authors.affiliation: Department of Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Saeideh
authors.initials: S
authors.lastname: Mazloomzadeh
keywords: Ceftriaxone; Monocytes; Rat model; Spinal cord injury