title: Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles.
abstract: Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinician team to ionizing radiation. Here we introduce a proof-of-concept development of a magnetic resonance imaging-guided catheter tracking method that utilizes hyperpolarized silicon particles. The increased signal of the silicon particles is generated via low-temperature, solid-state dynamic nuclear polarization, and the particles retain their enhanced signal for ≥ 40 minutes--allowing imaging experiments over extended time durations. The particles are affixed to the tip of standard medical-grade catheters and are used to track passage under set distal and temporal points in phantoms and live mouse models. With continued development, this method has the potential to supplement x-ray fluoroscopy and other MRI-guided catheter tracking methods as a zero-background, positive contrast agent that does not require ionizing radiation.
authors.affiliation: Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Whiting
authors.affiliation: 1] Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 [2] Department of Bioengineering, Rice University, Houston, TX 77030.
authors.forename: Jingzhe
authors.initials: J
authors.lastname: Hu
authors.affiliation: 1] Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 [2] Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712.
authors.forename: Jay V
authors.initials: JV
authors.lastname: Shah
authors.affiliation: Kavli Institute of NanoScience, Delft University of Technology, Delft, Netherlands.
authors.forename: Maja C
authors.initials: MC
authors.lastname: Cassidy
authors.affiliation: Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston TX 77030.
authors.forename: Erik
authors.initials: E
authors.lastname: Cressman
authors.affiliation: Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
authors.forename: Niki Zacharias
authors.initials: NZ
authors.lastname: Millward
authors.affiliation: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston TX, 77030.
authors.forename: David G
authors.initials: DG
authors.lastname: Menter
authors.affiliation: Niels Bohr Institute, University of Copenhagen, Denmark.
authors.forename: Charles M
authors.initials: CM
authors.lastname: Marcus
authors.affiliation: Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
authors.forename: Pratip K
authors.initials: PK
authors.lastname: Bhattacharya
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D005471:Fluoroscopy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D019047:Phantoms, Imaging; D012825:Silicon / Q000737:chemistry*; D013997:Time Factors; D062885:Urinary Catheters; D062666:Vascular Access Devices
chemical_list: D003287:Contrast Media; D012825:Silicon