title: Comparative assessment of parametric neuroreceptor mapping approaches based on the simplified reference tissue model using [¹¹C]ABP688 PET.
abstract: In recent years, several linearized model approaches for fast and reliable parametric neuroreceptor mapping based on dynamic nuclear imaging have been developed from the simplified reference tissue model (SRTM) equation. All the methods share the basic SRTM assumptions, but use different schemes to alleviate the effect of noise in dynamic-image voxels. Thus, this study aimed to compare those approaches in terms of their performance in parametric image generation. We used the basis function method and MRTM2 (multilinear reference tissue model with two parameters), which require a division process to obtain the distribution volume ratio (DVR). In addition, a linear model with the DVR as a model parameter (multilinear SRTM) was used in two forms: one based on linear least squares and the other based on extension of total least squares (TLS). Assessment using simulated and actual dynamic [(11)C]ABP688 positron emission tomography data revealed their equivalence with the SRTM, except for different noise susceptibilities. In the DVR image production, the two multilinear SRTM approaches achieved better image quality and regional compatibility with the SRTM than the others, with slightly better performance in the TLS-based method.
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea.|Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.|Medical Research Center, Institute of Radiation Medicine, Seoul National University, Seoul, Korea.
authors.forename: Seongho
authors.initials: S
authors.lastname: Seo
authors.affiliation: Neuroscience Research Institute, Gachon University, Incheon, Korea.
authors.forename: Su J
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Seoul National University-Seoul Metropolitan Government Boramae Medical Center, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Yu K
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Department of Neurology, Seoul National University-Seoul Metropolitan Government Boramae Medical Center, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Jee-Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea.|Medical Research Center, Institute of Radiation Medicine, Seoul National University, Seoul, Korea.
authors.forename: Jae M
authors.initials: JM
authors.lastname: Jeong
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea.|Medical Research Center, Institute of Radiation Medicine, Seoul National University, Seoul, Korea.|Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
authors.forename: Dong S
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea.|Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.|Medical Research Center, Institute of Radiation Medicine, Seoul National University, Seoul, Korea.|Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Jae S
authors.initials: JS
authors.lastname: Lee
mesh_terms: D000465:Algorithms; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016018:Least-Squares Analysis; D016014:Linear Models; D010091:Oximes; D010300:Parkinson Disease / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D011725:Pyridines; D019275:Radiopharmaceuticals; D012016:Reference Values; D011984:Sensory Receptor Cells
chemical_list: C510950:3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime; D010091:Oximes; D011725:Pyridines; D019275:Radiopharmaceuticals