title: Beneficial effects of a cardiac support device on left ventricular remodeling after posterior myocardial infarction: an evaluation by echocardiography, pressure-volume curves and ventricular histology.
abstract: OBJECTIVE
  Posterior myocardial infarction (MI) can induce LV remodeling and ischemic mitral regurgitation (IMR). The protective effects of a cardiac support device (CSD) against LV remodeling and IMR after posterior MI have been poorly documented.
  
  
  METHODS
  Posterior MI was induced by ligation of the left circumflex coronary artery in beagle dogs. After 7 days, the dogs were randomized to a CSD placement (CSD group, n = 8) or no treatment (CTL group, n = 8).
  
  
  RESULTS
  At 3 months after MI, the LV remodeling was less marked and the LV and RV systolic functions were better in the CSD group than in the CTL group. Neither the RV nor LV diastolic function (min dP/dt, Tau and EDPVR) was disturbed by the CSD. IMR was consistently prevented in our canine model.
  
  
  CONCLUSIONS
  Early application of a CSD after posterior MI can attenuate LV remodeling without causing any deterioration of the biventricular diastolic function.
authors.affiliation: Department of Cardiovascular Surgery, Kanazawa Medical University, Daigaku 1-1, Uchinadamachi, Kahokugun, Ishikawa, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Okada
authors.affiliation: Department of Cardiovascular Surgery, Kanazawa Medical University, Daigaku 1-1, Uchinadamachi, Kahokugun, Ishikawa, Japan. takita@kanazawa-med.ac.jp.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Akita
authors.affiliation: Department of Cardiovascular Surgery, Kanazawa Medical University, Daigaku 1-1, Uchinadamachi, Kahokugun, Ishikawa, Japan.
authors.forename: Fumito
authors.initials: F
authors.lastname: Mizuno
authors.affiliation: Department of Cardiovascular Surgery, Kanazawa Medical University, Daigaku 1-1, Uchinadamachi, Kahokugun, Ishikawa, Japan.
authors.forename: Asami
authors.initials: A
authors.lastname: Nakayama
authors.affiliation: Department of Cardiovascular Surgery, Kanazawa Medical University, Daigaku 1-1, Uchinadamachi, Kahokugun, Ishikawa, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Morioka
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004452:Echocardiography; D006352:Heart Ventricles / Q000473:pathology*; D006353:Heart-Assist Devices; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000517:prevention & control; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D020257:Ventricular Remodeling
keywords: Cardiac support device; Ischemic mitral regurgitation; Left ventricular remodeling; Posterior myocardial infarction; Pressure–volume relationship