title: Effect of low dose pioglitazone on glycemic control and insulin resistance in Type 2 diabetes: A randomized, double blind, clinical trial.
abstract: This study shows that pioglitazone 7.5 mg/day as an add-on therapy in Southeast Asian patients with Type 2 diabetes is safer and equally efficacious as the 15- and 30-mg doses of pioglitazone. Hence it is prudent to start pioglitazone therapy at a lower dose of 7.5 mg/day.
authors.affiliation: Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
authors.forename: Sujit
authors.initials: S
authors.lastname: Rajagopalan
authors.affiliation: Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
authors.forename: Pinaki
authors.initials: P
authors.lastname: Dutta
authors.affiliation: Department of Pharmacology, AIIMS, Bhubaneswar, India.
authors.forename: Debasish
authors.initials: D
authors.lastname: Hota
authors.affiliation: Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. Electronic address: anilbhansaliendocrine@gmail.com.
authors.forename: Anil
authors.initials: A
authors.lastname: Bhansali
authors.affiliation: Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Srinivasan
authors.affiliation: Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
authors.forename: Amitava
authors.initials: A
authors.lastname: Chakrabarti
mesh_terms: D000328:Adult; D001210:Asia, Southeastern / Q000453:epidemiology; D044466:Asian People; D001786:Blood Glucose / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D000077205:Pioglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008055:Lipids; D000077205:Pioglitazone; D045162:Thiazolidinediones
keywords: Insulin resistance; Low dose; Pioglitazone; Thiazolidinediones; Type 2 diabetes