title: [A young woman with skin necrosis after sclerotherapy].
abstract: A 23-year-old woman developed painful skin necrosis after injections with lauromacrogol 400 for varicose veins. This complication, called embolia cutis medicamentosa or Nicolau syndrome, is characterised by acute pain and necrosis of the skin, subcutaneous tissue and muscle. Surgical intervention by local excision seems to be the best therapy.
authors.affiliation: Venocare, Veldhoven.
authors.forename: Loes M C F
authors.initials: LM
authors.lastname: Bieleveld
authors.forename: Marjan J W
authors.initials: MJ
authors.lastname: Aldenzee
mesh_terms: D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D009336:Necrosis; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000009:adverse effects* / Q000627:therapeutic use; D012597:Sclerosing Solutions / Q000009:adverse effects* / Q000627:therapeutic use; D015911:Sclerotherapy / Q000009:adverse effects*; D012867:Skin / Q000098:blood supply; D012871:Skin Diseases / Q000139:chemically induced* / Q000601:surgery; D014648:Varicose Veins / Q000628:therapy
chemical_list: D012597:Sclerosing Solutions; D000077423:Polidocanol; D011092:Polyethylene Glycols