title: Graphene-like two-dimensional layered nanomaterials: applications in biosensors and nanomedicine.
abstract: The development of nanotechnology provides promising opportunities for various important applications. The recent discovery of atomically-thick two-dimensional (2D) nanomaterials can offer manifold perspectives to construct versatile devices with high-performance to satisfy multiple requirements. Many studies directed at graphene have stimulated renewed interest on graphene-like 2D layered nanomaterials (GLNs). GLNs including boron nitride nanosheets, graphitic-carbon nitride nanosheets and transition metal dichalcogenides (e.g. MoS2 and WS2) have attracted significant interest in numerous research fields from physics and chemistry to biology and engineering, which has led to numerous interdisciplinary advances in nano science. Benefiting from the unique physical and chemical properties (e.g. strong mechanical strength, high surface area, unparalleled thermal conductivity, remarkable biocompatibility and ease of functionalization), these 2D layered nanomaterials have shown great potential in biochemistry and biomedicine. This review summarizes recent advances of GLNs in applications of biosensors and nanomedicine, including electrochemical biosensors, optical biosensors, bioimaging, drug delivery and cancer therapy. Current challenges and future perspectives in these rapidly developing areas are also outlined. It is expected that they will have great practical foundation in biomedical applications with future efforts.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China. jjzhu@nju.edu.cn.
authors.forename: Guohai
authors.initials: G
authors.lastname: Yang
authors.forename: Chengzhou
authors.initials: C
authors.lastname: Zhu
authors.forename: Dan
authors.initials: D
authors.lastname: Du
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhu
authors.forename: Yuehe
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D001896:Boron Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004220:Disulfides / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D055664:Electrochemical Techniques; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008982:Molybdenum / Q000737:chemistry; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D009570:Nitriles / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D014057:Tomography, X-Ray Computed
chemical_list: D001896:Boron Compounds; D004220:Disulfides; D004337:Drug Carriers; D009570:Nitriles; C017282:boron nitride; D011092:Polyethylene Glycols; C011206:cyanogen; D006108:Graphite; D008982:Molybdenum; C082964:molybdenum disulfide