title: The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer's Disease.
abstract: OBJECTIVE
  We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans.
  
  
  METHODS
  Patients who met the criteria for probable Alzheimer's disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student's t-test.
  
  
  RESULTS
  At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (p=0.02 for MMSE-KC and p=0.03 for CERAD-K(N) WSS respectively).
  
  
  CONCLUSIONS
  Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.
authors.affiliation: Department of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Korea.
authors.forename: Kang Uk
authors.initials: KU
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Korea.
authors.forename: Jung Hie
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.|Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Dong Young
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Korea.
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Youn
authors.affiliation: Department of Psychiatry, Chungnam National University Hospital, Daejeon, Korea.
authors.forename: Jeong Lan
authors.initials: JL
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Konkuk University Chungju Hospital, Chungju, Korea.
authors.forename: Seok Woo
authors.initials: SW
authors.lastname: Moon
authors.affiliation: Department of Psychiatry, Gyeongsang National University Hospital, Jinju, Korea.
authors.forename: Bong-Jo
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Department of Neuropsychiatry, Konkuk University Hospital, Seoul, Korea.
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Ryu
authors.affiliation: Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea.
authors.forename: Moon Doo
authors.initials: MD
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Chang-Uk
authors.initials: CU
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Jeonju City Welfare Hospital for the Elderly, Jeonju, Korea.
authors.forename: Nam-Jin
authors.initials: NJ
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Kyungbook National University Hospital, Daegu, Korea.
authors.forename: Sung Man
authors.initials: SM
authors.lastname: Chang
authors.affiliation: Department of Psychiatry, Haeundae Paik Hospital, Busan, Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Chuncheon Sacred Hospital, Chuncheon, Korea.
authors.forename: Do Hoon
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.
authors.forename: Hae-Kook
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jong Inn
authors.initials: JI
authors.lastname: Woo
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.|Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Korea.|Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Korea.
authors.forename: Jin Hyeong
authors.initials: JH
authors.lastname: Jhoo
keywords: Alzheimer disease; Choline acetyltransferase; Donepezil; Single nucleotide polymorphism