title: Auto-fluorescent mesoporous ZnO nanospheres for drug delivery carrier application.
abstract: The zinc oxide (ZnO) nanostructures are very interesting materials because of their practical bio-applications in various areas such as drug delivery, construction of biomaterial, optical and acoustic devices as well as their bactericidal properties. Herein, we have prepared spheroidal mesoporous auto-fluorescent ZnO nanospheres by modified continuous distillation method, showed a blue emission in the concentration of 2mg/ml at 444nm. The auto-fluorescent property of ZnO nanospheres can be used in biomaterials for target sites of tissues/cells, thereby enabling site drug delivery especially in cancer therapy. Initially, the auto-fluorescent property of the ZnO material was characterized by different techniques like PXRD, FESEM with EDAX graph, TEM, ICP-OES, particle sizes, zeta potentials and BET analysis. The mesoporous ZnO nanospheres has attracted well for their crystalline, functionalized and intensified fluorescent properties. The surface of the ZnO nanospheres was porous, spherical and nanometric in size. The synthesized material has enormous potential as a nano-drug-carrier. Preliminary studies indicated that the material prepared has an excellent scope for detection and delivery at the site of therapeutic action.
authors.affiliation: Industrial Chemistry Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research), Chennai 600 020, India.
authors.forename: Haja Bava
authors.initials: HB
authors.lastname: Bakrudeen
authors.affiliation: Industrial Chemistry Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research), Chennai 600 020, India.
authors.forename: Madurai
authors.initials: M
authors.lastname: Sugunalakshmi
authors.affiliation: Industrial Chemistry Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research), Chennai 600 020, India. Electronic address: induchem2000@yahoo.com.
authors.forename: Boreddy S R
authors.initials: BS
authors.lastname: Reddy
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D005453:Fluorescence; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D015034:Zinc Oxide
keywords: Auto-fluorescent; Drug carrier; Mesoporous ZnO; Nanospheres