title: Comparison of right ventricular contractile abnormalities in hypertrophic cardiomyopathy versus hypertensive heart disease using two dimensional strain imaging: a cross-sectional study.
abstract: Hypertrophic cardiomyopathy (HCM) affects the right ventricle (RV) because of the anatomically hypertrophied septum and plausibly by extension of the myopathic process to the RV. We sought to investigate RV strain in patients with left ventricular hypertrophy secondary to either HCM or hypertension (H-LVH). Our cross-sectional study included 32 patients with HCM, 21 patients with H-LVH, and 11 healthy subjects, who were evaluated with transthoracic echocardiography. Using a dedicated software package, bi-dimensional acquisitions were analyzed to measure segmental longitudinal strain in apical views. Right ventricular global longitudinal strain (GLS) was calculated by averaging septal and right free wall strains. The HCM and H-LVH groups were comparable for age and demographic characteristics. Right ventricular tricuspid annular plane systolic excursion was not significantly different between HCM and H-LVH subjects. Moreover, RV GLS, septal and lateral RV myocardial strain were significantly impaired in patients with HCM (all p < 0.001). Regional and global RV strain parameters were not significantly impaired in H-LVH compared to healthy controls An RV GLS cut-off value of >14.9% differentiated HCM and H-LVH with a 90% sensitivity and a 95% specificity (p < 0.001). RV strain parameters are impaired in patients with HCM. Assessment of two-dimensional RV strain parameters could help differentiate between HCM and H-LVH.
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA. lafonso@med.wayne.edu.
authors.forename: Luis
authors.initials: L
authors.lastname: Afonso
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA. abriasou@med.wayne.edu.
authors.forename: Alex
authors.initials: A
authors.lastname: Briasoulis
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA.
authors.forename: Nitin
authors.initials: N
authors.lastname: Mahajan
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kondur
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA.
authors.forename: Fayez
authors.initials: F
authors.lastname: Siddiqui
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA.
authors.forename: Sabeeh
authors.initials: S
authors.lastname: Siddiqui
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA.
authors.forename: Issa
authors.initials: I
authors.lastname: Alesh
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA.
authors.forename: Shaun
authors.initials: S
authors.lastname: Cardozo
authors.affiliation: Division of Cardiology, Harper University Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, 48201, USA.
authors.forename: Anupama
authors.initials: A
authors.lastname: Kottam
mesh_terms: D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D015588:Observer Variation; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D012984:Software; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D016278:Ventricular Function, Right
keywords: Hypertrophic cardiomyopathy; Left ventricular hypertrophy; Right ventricular strain; Speckle tracking imaging; Strain imaging