title: Non-clinical toxicity studies on bioactive compounds within the framework of nutritional and health claims.
abstract: The growing presence of products on the market with added value in terms of health makes essential their regulation and harmonization in critical aspects such as safety. The toxicology applied to the bioactive compounds should demonstrate the absence of toxic effects at doses advised for consumption, as well as evaluate the potential toxic effects in the assumption that the products are used in quantities superior to those recommended. The specific strategy should be defined case by case; therefore, prior to any toxicological development, it is essential to study all the information regarding the bioactive compounds (BACs) characterization, nutridynamics and nutrikinetics, that is available. In this guideline, a general strategy to be applied in the development of BACs is proposed. It includes a first in vitro phase to discard genotoxicity and endocrine effects and a second in vivo phase with different possibilities regarding the duration and the extension of the studies.
authors.affiliation: Department of Pharmacology and Toxicology, University of Navarra , Pamplona , Spain and.
authors.forename: Ana Gloria
authors.initials: AG
authors.lastname: Gil
authors.forename: Leire
authors.initials: L
authors.lastname: Arbillaga
authors.forename: Adela
authors.initials: A
authors.lastname: López de Cerain
mesh_terms: D001682:Biological Availability; D005504:Food Analysis / Q000379:methods*; D005515:Food Labeling / Q000331:legislation & jurisprudence / Q000592:standards*; D059022:Food Safety / Q000379:methods*; D055951:Functional Food / Q000009:adverse effects / Q000592:standards*; D007881:Legislation, Food; D009753:Nutritive Value
keywords: Bioactive compounds; development strategy safety; endocrine effects; genotoxicity; non-clinical toxicology