title: Detecting tones in complex auditory scenes.
abstract: In everyday life, our auditory system is bombarded with many signals in complex auditory scenes. Limited processing capacities allow only a fraction of these signals to enter perceptual awareness. This magnetoencephalography (MEG) study used informational masking to identify the neural mechanisms that enable auditory awareness. On each trial, participants indicated whether they detected a pair of sequentially presented tones (i.e., the target) that were embedded within a multi-tone background. We analysed MEG activity for 'hits' and 'misses', separately for the first and second tones within a target pair. Comparing physically identical stimuli that were detected or missed provided insights into the neural processes underlying auditory awareness. While the first tone within a target elicited a stronger early P50m on hit trials, only the second tone evoked a negativity at 150 ms, which may index segregation of the tone pair from the multi-tone background. Notably, a later sustained deflection peaking around 300 and 500 ms (P300m) was the only component that was significantly amplified for both tones, when they were detected pointing towards its key role in perceptual awareness. Additional Dynamic Causal Modelling analyses indicated that the negativity at 150 ms underlying auditory stream segregation is mediated predominantly via changes in intrinsic connectivity within auditory cortices. By contrast, the later P300m response as a signature of perceptual awareness relies on interactions between parietal and auditory cortices. In conclusion, our results suggest that successful detection and hence auditory awareness of a two-tone pair within complex auditory scenes relies on recurrent processing between auditory and higher-order parietal cortices.
authors.affiliation: Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany.
authors.forename: Anette S
authors.initials: AS
authors.lastname: Giani
authors.affiliation: Department for Neurology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, 72076 Tübingen, Germany. Electronic address: paolo.belardinelli@uni-tuebingen.de.
authors.forename: Paolo
authors.initials: P
authors.lastname: Belardinelli
authors.affiliation: Department for Neurology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, 72076 Tübingen, Germany.
authors.forename: Erick
authors.initials: E
authors.lastname: Ortiz
authors.affiliation: Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Kleiner
authors.affiliation: Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany; Centre for Computational Neuroscience and Cognitive Robotics, Department of Psychology, University of Birmingham, B15 2TT Birmingham, UK.
authors.forename: Uta
authors.initials: U
authors.lastname: Noppeney
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001364:Awareness / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D055815:Young Adult