title: Intraoperative radiotherapy for early breast cancer and age: clinical characteristics and outcomes.
abstract: BACKGROUND
  Eligibility criteria for intraoperative radiation therapy (IORT) for breast cancer are being established. Impact of age, one criterion, on short-term complications/outcomes was evaluated.
  
  
  METHODS
  Institutional Review Board approved retrospective review of early-stage breast cancer patients undergoing breast conserving surgery and IORT from January 2011 to June 2013 were reviewed. Data collected were demographics, comorbidities, histopathology, intraoperative data, adjuvant treatment, and outcomes. Local recurrence (LR), re-excision rates, and complications were evaluated by age group using descriptive statistics.
  
  
  RESULTS
  The total number of patients was 100 (43 patients <70, 57 patients ≥70). No significant differences existed between groups in tumor size, operative time, estrogen receptor status, nodal status, tumor grade, or margin excision. Wound infection rates were low for both groups (P = .21). Two LR occurred (both patients ≥70). Median follow-up time was 24 months.
  
  
  CONCLUSIONS
  IORT with its low rate of LR and wound complications may be a reasonable alternative to whole breast irradiation for early-stage breast cancer, regardless of age.
authors.affiliation: Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Abbott
authors.affiliation: Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Lesly A
authors.initials: LA
authors.lastname: Dossett
authors.affiliation: Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Loretta
authors.initials: L
authors.lastname: Loftus
authors.affiliation: Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Weihong
authors.initials: W
authors.lastname: Sun
authors.affiliation: Division of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: William
authors.initials: W
authors.lastname: Fulp
authors.affiliation: Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Sokol
authors.affiliation: Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: Christine.largona@moffitt.org.
authors.forename: Christine
authors.initials: C
authors.lastname: Laronga
mesh_terms: D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D002277:Carcinoma / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
keywords: Accelerated partial breast radiation; Breast cancer; Elderly; Intraoperative radiation therapy; Surgical outcomes