title: Comparison of diffusion-weighted imaging findings in brain metastases of different origin.
abstract: Our purpose was to estimate apparent diffusion coefficient (ADC) values from brain metastases (BMs). Our patient sample included 159 patients with 948 BMs. Magnetic resonance imaging was obtained with a 1.5-T device. For diffusion-weighted imaging, a multislice single-shot echo-planar imaging sequence was used (b values of 0, 500, and 1000 s/mm(2)). The mean ADC value of BMs was 0.98 ± 0.32 × 10(-3) mm(2) s(-1). A total of 72.8% of BM lesions showed ADC values under 0.90 × 10(-3) mm(2) s(-1). Small-cell lung cancer had the lowest ADC values (0.86 ± 0.27) in comparison to BMs from non-small-cell lung cancer (1.17 ± 0.49), breast carcinoma (0.97 ± 0.21), and malignant melanoma (0.99 ± 0.36).
authors.affiliation: Department of Radiology, Martin Luther University, Halle, Wittenberg. Electronic address: Jonas90.Meyer@web.de.
authors.forename: Hans-Jonas
authors.initials: HJ
authors.lastname: Meyer
authors.affiliation: Department of Dermatology, Martin Luther University, Halle, Wittenberg. Electronic address: eckhard.fiedler@medizin.uni-halle.de.
authors.forename: Eckhard
authors.initials: E
authors.lastname: Fiedler
authors.affiliation: Department of Neurology, Martin Luther University, Halle, Wittenberg. Electronic address: malte.kornhuber@medizin.uni-halle.de.
authors.forename: Malte
authors.initials: M
authors.lastname: Kornhuber
authors.affiliation: Department of Radiology, Martin Luther University, Halle, Wittenberg. Electronic address: rolf.spielmann@medizin.uni-halle.de.
authors.forename: Rolf Peter
authors.initials: RP
authors.lastname: Spielmann
authors.affiliation: Department of Radiology, Martin Luther University, Halle, Wittenberg. Electronic address: alex.surow@medizin.uni-halle.de.
authors.forename: Alexey
authors.initials: A
authors.lastname: Surov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008545:Melanoma / Q000556:secondary*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*; D055752:Small Cell Lung Carcinoma / Q000556:secondary*; D055815:Young Adult
keywords: ADC; Brain metastases; DWI; MRI