title: Goal-Directed Therapy for Sepsis: Has the Beast Been Slain or Do Questions Remain?
abstract: The identification and early management of severe sepsis and septic shock has undergone a significant evolution over the past decade and a half. Recently two large multicentered trials were published contradicting the original Early-Goal Directed Therapy (EGDT) trial published in 2001. In this commentary we evaluate the current trials place in the historical context of negative and positive trial's on EGDT sepsis resuscitation.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Wira
authors.forename: Kai
authors.initials: K
authors.lastname: Swenson
mesh_terms: D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D005440:Fluid Therapy; D006801:Humans; D018805:Sepsis / Q000628:therapy*; D012772:Shock, Septic / Q000628:therapy