title: [MODERN APPROACHES TO PERIOPERATIVE THERAPY FOR LUNG CANCER: "PRO" AND "CONTRA" FROM THE PERSPECTIVE OF EVIDENCE-BASED MEDICINE].
abstract: Patients with resectable non-small cell lung cancer have a chance to reach a 5-year survival rates ranging from 70% or more for stage IA and 20% for stage IIIA. These figures have remained stable for the past 20 years. Moreover, the inability to improve long-term outcomes is generally determined by a fatal disease progression due to the emergence of distant metastases or local recurrence often in combination with systemic progression process. Thus the use of chemotherapy both in neoadjuvant and adjuvant regimens has stimulated for a long time the search for the optimal scheme and treatment options. This article presents a critical analysis of the current state of the problem of neoadjuvant and adjuvant chemotherapy as well as chemoradiotherapy in order to optimize the tactics of combined treatment of these groups of patients.
authors.forename: M D
authors.initials: MD
authors.lastname: Ter-Ovanesov
authors.forename: O E
authors.initials: OE
authors.lastname: Fatuev
authors.forename: A A
authors.initials: AA
authors.lastname: Aksarin
authors.forename: G A
authors.initials: GA
authors.lastname: Baksiyan
authors.forename: A V
authors.initials: AV
authors.lastname: Levitsky
authors.forename: E E
authors.initials: EE
authors.lastname: Lesnidze
authors.forename: M Yu
authors.initials: MY
authors.lastname: Kukosh
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000628:therapy*; D059186:Chemoradiotherapy, Adjuvant; D017024:Chemotherapy, Adjuvant; D018450:Disease Progression; D019317:Evidence-Based Medicine; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000628:therapy*; D020360:Neoadjuvant Therapy / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents