title: Propagation Curve and Velocity of Swallowing Pressure in Healthy Young Adults.
abstract: The objective of this study is to construct a propagation curve and determine propagation velocities in young healthy adults examined using a 2.64-mm-diameter high-resolution manometry catheter with 36 circumferential sensors; to explore data reproducibility; and to determine whether the swallowing pressure (SP) propagation velocity correlated with bolus volume. Repeated measures with subjects serving as their own controls. Thirty healthy subjects (average age 25.3 years) swallowed saliva and 2, 5, and 10 mL of cold water to determine the maximum SP from the soft palate to the cervical esophagus. The SP propagation curve was obtained by plotting the duration to reach each SP peak. The SP propagation velocity was calculated for each region. These parameters were examined according to bolus size and gender. The intra-class correlation coefficient for estimating the SP propagation curves was >0.61 (i.e., highly consistent). The propagation velocity was maximal at the meso-hypopharynx and minimal at the UES and cervical esophagus. The SP propagation curve was very reproducible within any subject. Neither the water volume (with the exception of 2 and 5 mL) nor gender exerted any apparent effect on velocity in any region. However, the velocity was quite variable at the cervical esophagus.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Kumamoto University Graduate School of Medicine, 1-1-1 Honjo, Chuo-ku, Kumamoto City, Kumamoto, 860-8556, Japan.
authors.forename: Keigo
authors.initials: K
authors.lastname: Matsubara
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Kumamoto University Graduate School of Medicine, 1-1-1 Honjo, Chuo-ku, Kumamoto City, Kumamoto, 860-8556, Japan. kumayoshi426yk@gmail.com.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kumai
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Kumamoto University Graduate School of Medicine, 1-1-1 Honjo, Chuo-ku, Kumamoto City, Kumamoto, 860-8556, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Samejima
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Kumamoto University Graduate School of Medicine, 1-1-1 Honjo, Chuo-ku, Kumamoto City, Kumamoto, 860-8556, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yumoto
mesh_terms: D003679:Deglutition / Q000502:physiology*; D049631:Esophageal Sphincter, Upper / Q000502:physiology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007013:Hypopharynx / Q000502:physiology*; D008297:Male; D008365:Manometry; D011312:Pressure; D015203:Reproducibility of Results; D055815:Young Adult
keywords: Propagation curve; Propagation velocity; Swallowing pressure