title: Pterocarpans and triterpenoids from Gueldenstaedtia verna.
abstract: Two new pterocarpan glycosides (1-2), five new triterpenoids (3-7), and 13 known analogues (14-20) were isolated from the whole plants of Gueldenstaedtia verna. These new compounds (1-7) were elucidated by extensive spectroscopic techniques including 1D ((1)H and (13)C) and 2D NMR experiments (COSY, HSQC, HMBC and NOESY), HR-ESI-MS and chemical methods. The absolute configuration of 1 was established by the optical rotation, the comparison of experimental and calculated electronic circular dichroism (ECD) spectra and an X-ray diffraction analysis. All the isolates were evaluated for their cytotoxicities against four human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Chengle
authors.initials: C
authors.lastname: Yin
authors.affiliation: Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jinge
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Shoude
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Honglin
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: chengzhh@fudan.edu.cn.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D007887:Fabaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D036343:Pterocarpans / Q000737:chemistry* / Q000302:isolation & purification; D000067996:RAW 264.7 Cells; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D006027:Glycosides; D036343:Pterocarpans; D014315:Triterpenes; D009569:Nitric Oxide
keywords: Cytotoxic activity; Gueldenstaedtia verna; Inhibition of NO production; Leguminosae; Pterocarpans; Triterpenoids