title: ANTIOXIDANT ACTIVITY OF ALKOXY DERIVATIVES OF (QUINOLINE-4-YLTHIO)CARBOXYLIC ACIDS.
abstract: A selection of potential bioactive molecules including alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids using virtual screening has been carried out and their biological activity was determined. The studied substances proved to be low-toxic, biologically active compounds. It was established that 4-thio derivatives of quinoline exhibit pronounced antiradical, antioxidant-effects and can act as preventive antioxidants, radio and cytoprotectors.
authors.forename: O O
authors.initials: OO
authors.lastname: Brazhko
authors.forename: M P
authors.initials: MP
authors.lastname: Zavgorodny
authors.forename: O S
authors.initials: OS
authors.lastname: Kruglyak
authors.forename: L O
authors.initials: LO
authors.lastname: Omeljanchik
authors.forename: G A
authors.initials: GA
authors.lastname: Shapoval
mesh_terms: D000323:Adrenochrome / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D055664:Electrochemical Techniques; D004837:Epinephrine / Q000737:chemistry; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009599:Nitroprusside / Q000737:chemistry; D010084:Oxidation-Reduction; D010659:Phenylhydrazines / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D002264:Carboxylic Acids; D010659:Phenylhydrazines; D011804:Quinolines; D011837:Radiation-Protective Agents; D009599:Nitroprusside; C004787:2,4-dinitrophenylhydrazine; D000323:Adrenochrome; D004837:Epinephrine