title: Boron analysis for neutron capture therapy using particle-induced gamma-ray emission.
abstract: The neutron source of BNCT is currently changing from reactor to accelerator, but peripheral facilities such as a dose-planning system and blood boron analysis have still not been established. To evaluate the potential application of particle-induced gamma-ray emission (PIGE) for boron measurement in clinical boron neutron capture therapy, boronophenylalanine dissolved within a cell culture medium was measured using PIGE. PIGE detected 18 μgB/mL f-BPA in the culture medium, and all measurements of any given sample were taken within 20 min. Two hours of f-BPA exposure was required to create a boron distribution image. However, even though boron remained in the cells, the boron on the cell membrane could not be distinguished from the boron in the cytoplasm.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Electronic address: knakai@md.tsukuba.ac.jp.
authors.forename: Kei
authors.initials: K
authors.lastname: Nakai
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Master's Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Okamoto
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Yoshida
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumura
authors.affiliation: Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute (TIARA), Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 379-1292, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamada
authors.affiliation: Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute (TIARA), Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 379-1292, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Kitamura
authors.affiliation: Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute (TIARA), Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 379-1292, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Koka
authors.affiliation: Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute (TIARA), Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 379-1292, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Satoh
mesh_terms: D001895:Boron / Q000032:analysis*; D016754:Boron Neutron Capture Therapy; D018929:Cell Culture Techniques; D003470:Culture Media; D005720:Gamma Rays
chemical_list: D003470:Culture Media; D001895:Boron
keywords: Boron; Particle-induced gamma-ray emission