title: Randainins A-D, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis.
abstract: Four new compounds, randainins A-D (1-4), were isolated from the leaves and twigs of Callicarpa randaiensis, which is an endemic species in Taiwan. Compounds 1 and 2 are diterpenoids with an unusual trans-7/5 ring system, whereas compounds 3 and 4 are diterpenoids possessing a trans-5/7 ring scaffold. The structures of the new compounds were established based on NMR and MS data analyses. Anti-inflammatory activities and cytotoxicity were tested and evaluated for these compounds. Compound 4 exhibited moderate inhibition of superoxide-anion generation with an IC50 value of 21.5 ± 2.5 μM.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University , Taipei 100, Taiwan.
authors.forename: Ho-Hsi
authors.initials: HH
authors.lastname: Cheng
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.affiliation: Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University , Taoyuan 33302 Taiwan.|Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology , Taoyuan 33302, Taiwan.|Immunology Consortium, Chang Gung Memorial Hospital , Taoyuan 33302, Taiwan.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine , Taipei 112, Taiwan.
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University , Taipei 100, Taiwan.
authors.forename: Chung-Hsiung
authors.initials: CH
authors.lastname: Chen
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University , Taipei 100, Taiwan.
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D032408:Callicarpa / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009504:Neutrophils / Q000201:enzymology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010196:Pancreatic Elastase / Q000032:analysis; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013624:Taiwan
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D010196:Pancreatic Elastase