title: Recent advances in local drug delivery to the inner ear.
abstract: Inner ear diseases are not adequately treated by systemic drug administration mainly because of the blood-perilymph barrier that reduces exchanges between plasma and inner ear fluids. Local drug delivery methods including intratympanic and intracochlear administrations are currently developed to treat inner ear disorders more efficiently. Intratympanic administration is minimally invasive but relies on diffusion through middle ear barriers for drug entry into the cochlea, whereas intracochlear administration offers direct access to the colchlea but is rather invasive. A wide range of drug delivery systems or devices were evaluated in research and clinic over the last decade for inner ear applications. In this review, different strategies including medical devices, hydrogels and nanoparticulate systems for intratympanic administration, and cochlear implant coating or advanced medical devices for intracoclear administration were explored with special attention to in vivo studies. This review highlights the promising systems for future clinical applications as well as the current hurdles that remain to be overcome for efficient inner ear therapy.
authors.affiliation: Université Paris-Sud, Faculté de Pharmacie, Institut Galien Paris-Sud, CNRS UMR 8612, 5 Rue J-B Clément, 92290 Châtenay-Malabry, France.
authors.forename: Naila
authors.initials: N
authors.lastname: El Kechai
authors.affiliation: Université Paris-Sud, Faculté de Pharmacie, Institut Galien Paris-Sud, CNRS UMR 8612, 5 Rue J-B Clément, 92290 Châtenay-Malabry, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Agnely
authors.affiliation: UMR-S 1159 Inserm/Université Pierre et Marie Curie - Sorbonne Universités "Minimally Invasive Robot-based Hearing Rehabilitation", 16 rue Henri Huchard, 75018 Paris, France; AP-HP, Pitié-Salpêtrière Hospital, Otolaryngology Department, Unit of Otology, Auditory Implants and Skull Base Surgery, Paris, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mamelle
authors.affiliation: UMR-S 1159 Inserm/Université Pierre et Marie Curie - Sorbonne Universités "Minimally Invasive Robot-based Hearing Rehabilitation", 16 rue Henri Huchard, 75018 Paris, France; AP-HP, Pitié-Salpêtrière Hospital, Otolaryngology Department, Unit of Otology, Auditory Implants and Skull Base Surgery, Paris, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Nguyen
authors.affiliation: UMR-S 1159 Inserm/Université Pierre et Marie Curie - Sorbonne Universités "Minimally Invasive Robot-based Hearing Rehabilitation", 16 rue Henri Huchard, 75018 Paris, France; AP-HP, Pitié-Salpêtrière Hospital, Otolaryngology Department, Unit of Otology, Auditory Implants and Skull Base Surgery, Paris, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Ferrary
authors.affiliation: Université Paris-Sud, Faculté de Pharmacie, Institut Galien Paris-Sud, CNRS UMR 8612, 5 Rue J-B Clément, 92290 Châtenay-Malabry, France. Electronic address: amelie.bochot@u-psud.fr.
authors.forename: Amélie
authors.initials: A
authors.lastname: Bochot
mesh_terms: D003051:Cochlea / Q000187:drug effects*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D007759:Labyrinth Diseases / Q000188:drug therapy*; D010498:Perilymph / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D004364:Pharmaceutical Preparations
keywords: Cochlea; Hydrogels; Intracochlear administration; Intratympanic administration; Medical drug delivery devices; Nanoparticulate systems