title: Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control.
abstract: Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics.
authors.affiliation: Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: diamond@wusm.wustl.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Diamond
authors.affiliation: Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: piersontc@mail.nih.gov.
authors.forename: Theodore C
authors.initials: TC
authors.lastname: Pierson
mesh_terms: D000818:Animals; D003715:Dengue / Q000276:immunology / Q000517:prevention & control / Q000628:therapy / Q000821:virology*; D053059:Dengue Vaccines / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology / Q000502:physiology*; D006801:Humans; D057131:Immune Evasion
chemical_list: D053059:Dengue Vaccines