title: Cholesterol ester transfer protein polymorphism rs5882 is associated with triglyceride-lowering in response to plant sterol consumption.
abstract: Recent work suggests that plant sterol (PS) consumption may lower triglyceride (TG) concentrations; however, human clinical trial evidence is inconsistent. We associated SNP r5882 in cholesteryl ester transfer protein with changes in TG concentrations following PS consumption (2 g/day for 4 weeks) in a dual-centre, single-blind, randomized, crossover trial. TG concentrations were lowered in homozygotes for the minor G-allele of rs5882 (-0.46 ± 0.13 mmol/L, p = 0.002, n = 10); there was no effect in the A-allele carriers.
authors.affiliation: a Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.|b Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
authors.forename: Dylan S
authors.initials: DS
authors.lastname: Mackay
authors.affiliation: b Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Eck
authors.affiliation: c Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Rideout
authors.affiliation: d United States Department of Agriculture (USDA), Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Baer
authors.affiliation: a Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.|b Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.|e Department of Food Science, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.
authors.forename: Peter J H
authors.initials: PJ
authors.lastname: Jones
mesh_terms: D000328:Adult; D000368:Aged; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood* / Q000235:genetics*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010840:Phytosterols / Q000008:administration & dosage / Q000097:blood* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood* / Q000235:genetics*
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D010840:Phytosterols; D014280:Triglycerides
keywords: CETP; nutrigenetics; nutrigénétique; phytosterols; phytostérols; plant sterols; stérols végétaux; triglycerides; triglycérides