title: Efficacy of Intralesional Botulinum Toxin A for Treatment of Painful Cutaneous Leiomyomas: A Randomized Clinical Trial.
abstract: OBJECTIVE
  Cutaneous leiomyomas can be associated with severe paroxysmal pain in which nerve conduction may have a key role. Medical management of painful cutaneous leiomyomas is generally unsatisfactory.
  
  
  OBJECTIVE
  To assess the efficacy of intralesional botulinum toxin A in the management of pain associated with cutaneous leiomyomas.
  
  
  METHODS
  Randomized, double-blind, placebo-controlled pilot study conducted from January 5, 2009, to March 27, 2014. The setting was a single-center study at the National Institutes of Health among participants 18 years or older with cutaneous leiomyomas characterized by pain at least once weekly and pain of at least 4 on a pain scale ranging from 0 to 10.
  
  
  METHODS
  Eighteen participants were randomized to receive intralesional botulinum toxin A (5 U per 1 cm2) or equivalent volumes of intralesional saline placebo.
  
  
  METHODS
  The primary outcomes were the differences in average lesional pain assessed by the Brief Pain Inventory and visual analog scale before and after ice provocation over a 4-week period.
  
  
  RESULTS
  No significant difference in average lesional pain was observed between the study arms. Decreased pain was reported in the botulinum toxin vs placebo arms by visual analog scale scores before ice provocation (median, 0.00; range, -3.30 to 0.70 for botulinum toxin and median, 0.40; range, -1.30 to 1.50 for placebo; P = .06); however, this finding was nonsignificant. No significant difference was observed in change in pain after ice provocation. A significant difference was seen between the arms in skin-related quality of life by total Dermatology Life Quality Index (median, -4.00; range, -8.00 to 2.00 for botulinum toxin and median, 0.00; range, -1.00 to 4.00 for placebo; P = .007) and with the specific skin pain-related question on the Dermatology Life Quality Index (median, -1.00; range, -2.00 to 1.00 for botulinum toxin and median, 0.00; range, -1.00 to 0.00 for placebo; P = .048). No significant difference was found in pain as ascertained by Patient Global Impression of Change at week 4. No serious adverse events related to botulinum toxin use were observed.
  
  
  CONCLUSIONS
  The use of botulinum toxin to treat painful cutaneous leiomyomas was associated with improved quality of life and with a trend toward improved pain at rest.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier: NCT00971620.
authors.affiliation: Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Haley B
authors.initials: HB
authors.lastname: Naik
authors.affiliation: Biostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Seth M
authors.initials: SM
authors.lastname: Steinberg
authors.affiliation: Urologic Surgery and the Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Middelton
authors.affiliation: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Hewitt
authors.affiliation: Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Rena C
authors.initials: RC
authors.lastname: Zuo
authors.affiliation: Urologic Surgery and the Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: W Marston
authors.initials: WM
authors.lastname: Linehan
authors.affiliation: Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Heidi H
authors.initials: HH
authors.lastname: Kong
authors.affiliation: Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Edward W
authors.initials: EW
authors.lastname: Cowen
mesh_terms: D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007889:Leiomyoma / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D010865:Pilot Projects; D011788:Quality of Life; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A