title: Gene Mutation Analysis in Determining Late Recurrence of Adenocarcinoma of the Lung.
abstract: A patient was found to have a new pleural lesion 14 years after undergoing complete resection of primary lung cancer. Histologic and genetic analysis of the previously resected specimen and the samples obtained of a newly performed biopsy confirmed that the tumors were identical, and the recurrence of lung cancer was determined. This case is instructive because of the rather long interval between the resection of the initial tumor and the recurrence and because of the presence of validated proof of recurrence by both clinical features and genetic analysis.
authors.affiliation: Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo, Japan. Electronic address: kondon@hyo-med.ac.jp.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Takuwa
authors.affiliation: Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoneda
authors.affiliation: Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Matsumoto
authors.affiliation: Department of General Thoracic, Breast, and Pediatric Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shiraishi
authors.affiliation: Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Seiki
authors.initials: S
authors.lastname: Hasegawa
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009154:Mutation
chemical_list: D004273:DNA, Neoplasm