title: High priority for hepatitis C screening in safety net hospitals: Results from a prospective cohort of 4582 hospitalized baby boomers.
abstract: Low-income populations are disproportionately affected by hepatitis C virus (HCV) infection. Thus, implementing baby boomer screening (born 1945-1965) for HCV may be a high priority for safety net hospitals. We report the prevalence and predictors of HCV infection and advanced fibrosis or cirrhosis based on the Fibrosis-4 score plus imaging for a baby boomer cohort admitted to a safety net hospital over a 21-month interval with >9 months of follow-up. Anti-HCV antibody testing was performed for 4582, or 90%, of all never-screened patients, of whom 312 (6.7%) tested positive. Adjusted odds ratios of testing anti-HCV-positive were 2.66 for men versus women (P<0.001), 1.25 for uninsured versus insured (P=0.06), 0.70 for Hispanics versus non-Hispanic whites (P=0.005), and 0.93 per year of age (P<0.001). Among 287 patients tested for HCV RNA (91% of all anti-HCV-positive cases), 175 (61%) were viremic (3.8% overall prevalence in cohort), which was 5% less likely per year of age (P<0.03). Noninvasive staging of 148 (84.6%) chronic HCV patients identified advanced fibrosis or cirrhosis in 50 (33.8%), with higher adjusted odds ratios of 3.21 for Hispanics versus non-Hispanic whites/Asians (P=0.02) and 1.18 per year of age (P=0.001). Other factors associated with significantly higher adjusted odds ratios of advanced fibrosis or cirrhosis were alcohol abuse/dependence, obesity, and being uninsured.
  
  
  CONCLUSIONS
  In this low-income, hospitalized cohort, 4% of 4582 screened baby boomers were diagnosed with chronic HCV, nearly twice the rate in the community; one-third had noninvasive testing that indicated advanced fibrosis or cirrhosis, which was significantly more likely for Hispanics, those of older age, those with obesity, those with alcohol abuse/dependence, and those who lacked insurance.
authors.affiliation: Department of Medicine and Center for Research to Advance Community Health, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Turner
authors.affiliation: Department of Medicine and Center for Research to Advance Community Health, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Taylor
authors.affiliation: Department of Medicine and Center for Research to Advance Community Health, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Joshua
authors.initials: J
authors.lastname: Hanson
authors.affiliation: Department of Epidemiology and Biostatistics and Center for Research to Advance Community Health, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Center for Research to Advance Community Health, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Poornachand
authors.initials: P
authors.lastname: Veerapaneni
authors.affiliation: University Health System, San Antonio, TX.
authors.forename: Roberto
authors.initials: R
authors.lastname: Villarreal
authors.affiliation: Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Mary
authors.initials: M
authors.lastname: Perez
authors.affiliation: Center for Research to Advance Community Health, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Ludivina
authors.initials: L
authors.lastname: Hernandez
authors.affiliation: School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Jasdeep
authors.initials: J
authors.lastname: Sandhu
authors.affiliation: Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX.
authors.forename: Kristin
authors.initials: K
authors.lastname: Fiebelkorn
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000175:diagnosis*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood
chemical_list: D018937:Hepatitis C Antibodies; D012367:RNA, Viral