title: Sorafenib: the gold standard therapy in advanced hepatocellular carcinoma and beyond.
authors.affiliation: Division of Oncology, "Mons. R Dimiccoli" Hospital, Viale Ippocrate, 15, 76121 Barletta (BT), Asl BAT, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Gadaleta-Caldarola
authors.affiliation: Clinical Pathology Laboratory, National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco, 65, 70100 Bari, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Divella
authors.affiliation: Interdisciplinary Department of Medicine, University of Bari School of Medicine, Piazza G. Cesare, 11, 70124 Bari, Italy.|National Institute for Digestive Diseases, IRCCS "Saverio De Bellis", Via Turi 27, 70013, Castellana Grotte, Bari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Mazzocca
authors.affiliation: Division of Oncology, "S Francesco di Paola" Hospital, Via Promintesta, 1, 87027 Paola (CS), ASP, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Infusino
authors.affiliation: Department of Internal Medicine & Clinical Specialties, University of Rome "La Sapienza", Policlinico Umberto I, Viale del Policlinico, 155, 00161 Roma, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Ferraro
authors.affiliation: Division of Oncology, "S Francesco di Paola" Hospital, Via Promintesta, 1, 87027 Paola (CS), ASP, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Filippelli
authors.affiliation: Clinical Pathology Laboratory, National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco, 65, 70100 Bari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Daniele
authors.affiliation: Interdisciplinary Department of Medicine, University of Bari School of Medicine, Piazza G. Cesare, 11, 70124 Bari, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Sabbà
authors.affiliation: Clinical Pathology Laboratory, National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco, 65, 70100 Bari, Italy.
authors.forename: Ines
authors.initials: I
authors.lastname: Abbate
authors.affiliation: Division of Oncology, "Mons. R Dimiccoli" Hospital, Viale Ippocrate, 15, 76121 Barletta (BT), Asl BAT, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Brandi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology*; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D009367:Neoplasm Staging; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010671:Phenylurea Compounds / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D000077157:Sorafenib; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D009536:Niacinamide; D000077157:Sorafenib
keywords: HCC; RAS/RAF/MEK/ERK pathway; multikinase inhibitors; sorafenib