title: Effects of single nucleotide polymorphisms in c-Myc on stable warfarin doses in patients with cardiac valve replacements.
abstract: OBJECTIVE
  This study aimed to investigate an association between c-Myc SNPs and stable warfarin doses.
  
  
  METHODS
  The influences of genetic polymorphisms on dose requirements were investigated by genotyping ten SNPs in 201 patients with stable warfarin doses; VKORC1 (rs9923231), CYP2C9 (rs1057910), CYP4F2 (rs2108622), GATA4 (rs10090884), c-Myc (rs4645962, rs4645943, rs4645948 and rs4645974) and 8q24 (rs1447295 and rs16901979).
  
  
  RESULTS
  Around 44.3% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; VKORC1 genotype accounted for 26.4%, CYP2C9 genotype for 4.9%, age for 3.4%, c-Myc genotypes for 5.2% (rs4645974 for 2.4% and rs4645943 for 2.8%), CYP4F2 genotype for 2.9% and diuretic use for 1.5%.
  
  
  CONCLUSIONS
  Our results revealed that c-Myc could be a determinant of stable warfarin doses.
authors.affiliation: College of Pharmacy & Division of Life & Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, South Korea.|College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, Chungbuk 361-763, South Korea.
authors.forename: Kyung E
authors.initials: KE
authors.lastname: Lee
authors.affiliation: Department of Thoracic & Cardiovascular Surgery, Yonsei University Medical Center, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, South Korea.
authors.forename: Byung C
authors.initials: BC
authors.lastname: Chang
authors.affiliation: College of Pharmacy & Division of Life & Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, South Korea.
authors.forename: Sunny
authors.initials: S
authors.lastname: Park
authors.affiliation: College of Pharmacy & Division of Life & Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, South Korea.
authors.forename: Hye S
authors.initials: HS
authors.lastname: Gwak
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D005838:Genotype; D006350:Heart Valve Prosthesis; D006351:Heart Valves / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D064417:Vitamin K Epoxide Reductases / Q000235:genetics; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D014859:Warfarin; D003577:Cytochrome P-450 Enzyme System; D064417:Vitamin K Epoxide Reductases
keywords: 8q24; VKORC1; c-Myc; transcription factor; warfarin