title: FoxO1 Inhibitors: The Future Medicine for Metabolic Disorders?
abstract: FoxO1, one of the most widely expressed sub-families of the winged helix forkhead factors, is biologically 'omni-functional' owing to its far-flung roles in metabolism, cell cycle, tissue differentiation and development and oxidative stress response. The knowledge of involvement of FoxO1 in metabolic disorders has long been there, but the potential target remained underutilized due to unavailability of specific and potent inhibitors. The review provides an insight into the role of FoxO1 in orchestrating metabolic diseases' pathogenesis (including diabetes, its secondary complications and obesity) and compiles the literature on FoxO1 inhibitors. The emergence of various natural molecules and synthesized small molecules like AS1842856 as FoxO1 inhibitors urges us to think further and decide the future course of drug development for the management of metabolic disorders.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Pandey
authors.forename: Goru Santosh
authors.initials: GS
authors.lastname: Kumar
authors.forename: Almesh
authors.initials: A
authors.lastname: Kadakol
authors.forename: Vajir
authors.initials: V
authors.lastname: Malek
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Pilani 333 031, Rajasthan, India. anil.gaikwad@pilani.bits-pilani.ac.in.
authors.forename: Anil Bhanudas
authors.initials: AB
authors.lastname: Gaikwad
mesh_terms: D000818:Animals; D048909:Diabetes Complications / Q000188:drug therapy / Q000235:genetics; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000235:genetics; D000071161:Forkhead Box Protein O1 / Q000037:antagonists & inhibitors* / Q000502:physiology; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D015363:Quinolones / Q000494:pharmacology* / Q000627:therapeutic use*; D035703:Therapies, Investigational / Q000379:methods / Q000639:trends*
chemical_list: C553926:5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; D000071161:Forkhead Box Protein O1; D015363:Quinolones