title: National decline in invasive prenatal diagnostic procedures in association with uptake of combined first trimester and cell-free DNA aneuploidy screening.
abstract: In late 2012, a new screening test for fetal aneuploidy based on circulating cell-free DNA (cfDNA) became available to Australian women. The introduction of this technology in the United States has led to a reduction in invasive diagnostic procedures. Analysis of the number of amniocentesis and chorionic villus sampling (CVS) procedures performed in Australia from 1994 to 2014 shows that the introduction of cfDNA testing has been associated with the most rapid decline in invasive procedures in the last 20 years. This change has important implications for training in, and maintenance of, the procedural skills of amniocentesis and CVS.
authors.affiliation: Australian National University Medical School, Garran, Australian Capital Territory, Australia.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Robson
authors.affiliation: Department of Perinatal Medicine, Mercy Hospital for Women, Heidelberg, Victoria, Australia.|Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.|Public Health Genetics, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
authors.forename: Lisa
authors.initials: L
authors.lastname: Hui
mesh_terms: D000328:Adult; D000649:Amniocentesis / Q000379:methods / Q000706:statistics & numerical data*; D000782:Aneuploidy; D001315:Australia; D002474:Cell-Free System; D016009:Chi-Square Distribution; D015193:Chorionic Villi Sampling / Q000379:methods / Q000706:statistics & numerical data*; D016001:Confidence Intervals; D004247:DNA / Q000032:analysis*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D006278:Medicare; D016017:Odds Ratio; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D014481:United States
chemical_list: D004247:DNA
keywords: amniocentesis; cell-free DNA; chorionic villus sampling; noninvasive prenatal testing; population; prenatal testing