title: Evaluating the Role of Birth Weight and Gestational Age on Acute Lymphoblastic Leukemia Risk Among Those of Hispanic Ethnicity.
abstract: High birth weight is an established risk factor for childhood acute lymphoblastic leukemia (ALL), especially in children younger than 5 years of age at diagnosis. The goal of this study was to explore the association between being born large for gestational age and the risk for ALL by race/ethnicity to determine if the role of this risk factor differed by these characteristics. The authors compared birth certificate data of 575 children diagnosed with ALL who were younger than 5 years and included in the Texas Cancer Registry, Texas Department of Health, between the years 1995 and 2003 with 11,379 controls matched by birth year. Stratified odds ratios were calculated for risk of ALL by birth weight for gestational age, categorized in 3 groups, small, appropriate, and large for gestational age (SGA, AGA, and LGA, respectively), for each race/ethnicity group. The risk of developing ALL was higher among Hispanics who were LGA (odds ratio [OR] = 1.90, 95% confidence interval [CI]: 1.34-2.68) compared with LGA non-Hispanic whites (OR = 1.27, 95% CI: 0.87-1.86) after adjusting for infant gender, year of birth, maternal age, birth order, and presence of Down syndrome. However, the difference was not statistically significant. These results suggest that there may be differences in the association between higher growth in utero and risk of childhood ALL among Hispanics versus non-Hispanic whites.
authors.affiliation: a Department of Pediatrics, Baylor College of Medicine , Texas Children's Cancer Center , Houston , Texas , USA.|b Childhood Cancer Prevention and Epidemiology Center , Houston , Texas , USA.
authors.forename: Nadia
authors.initials: N
authors.lastname: Barahmani
authors.affiliation: d School of Health Sciences , Liverpool Hope University , Liverpool , United Kingdom.
authors.forename: M Tevfik
authors.initials: MT
authors.lastname: Dorak
authors.affiliation: c School of Human Ecology , The University of Texas at Austin , Austin , Texas , USA.
authors.forename: Michele R
authors.initials: MR
authors.lastname: Forman
authors.affiliation: a Department of Pediatrics, Baylor College of Medicine , Texas Children's Cancer Center , Houston , Texas , USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sprehe
authors.affiliation: a Department of Pediatrics, Baylor College of Medicine , Texas Children's Cancer Center , Houston , Texas , USA.|b Childhood Cancer Prevention and Epidemiology Center , Houston , Texas , USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scheurer
authors.affiliation: a Department of Pediatrics, Baylor College of Medicine , Texas Children's Cancer Center , Houston , Texas , USA.|b Childhood Cancer Prevention and Epidemiology Center , Houston , Texas , USA.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Bondy
authors.affiliation: a Department of Pediatrics, Baylor College of Medicine , Texas Children's Cancer Center , Houston , Texas , USA.|b Childhood Cancer Prevention and Epidemiology Center , Houston , Texas , USA.
authors.forename: M Fatih
authors.initials: MF
authors.lastname: Okcu
authors.affiliation: a Department of Pediatrics, Baylor College of Medicine , Texas Children's Cancer Center , Houston , Texas , USA.|b Childhood Cancer Prevention and Epidemiology Center , Houston , Texas , USA.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Lupo
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology*; D012042:Registries; D013781:Texas / Q000453:epidemiology / Q000208:ethnology
keywords: ALL; cancer control; epidemiology