title: Prediction of Balance Compensation After Vestibular Schwannoma Surgery.
abstract: Background Balance compensation after vestibular schwannoma (VS) surgery is under the influence of specific preoperative patient and tumor characteristics. Objective To prospectively identify potential prognostic factors for balance recovery, we compared the respective influence of these preoperative characteristics on balance compensation after VS surgery. Methods In 50 patients scheduled for VS surgical ablation, we measured postural control before surgery (BS), 8 (AS8) days after, and 90 (AS90) days after surgery. Based on factors found previously in the literature, we evaluated age, body mass index and preoperative physical activity (PA), tumor grade, vestibular status, and preference for visual cues to control balance as potential prognostic factors using stepwise multiple regression models. Results An asymmetric vestibular function was the sole significant explanatory factor for impaired balance performance BS, whereas the preoperative PA alone significantly contributed to higher performance at AS8. An evaluation of patients' balance recovery over time showed that PA and vestibular status were the 2 significant predictive factors for short-term postural compensation (BS to AS8), whereas none of these preoperative factors was significantly predictive for medium-term postoperative postural recovery (AS8 to AS90). Conclusions We identified specific preoperative patient and vestibular function characteristics that may predict postoperative balance recovery after VS surgery. Better preoperative characterization of these factors in each patient could inform more personalized presurgical and postsurgical management, leading to a better, more rapid balance recovery, earlier return to normal daily activities and work, improved quality of life, and reduced medical and societal costs.
authors.affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital of Nancy, Nancy, France Laboratory "Développement, Adaptation et Handicap" (DevAH - EA 3450), University of Lorraine, Vandœuvre-lès-Nancy, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Parietti-Winkler
authors.affiliation: Laboratory "Développement, Adaptation et Handicap" (DevAH - EA 3450), University of Lorraine, Vandœuvre-lès-Nancy, France Sport Medicine Research Laboratory, Luxembourg Institute of Health, Luxembourg.
authors.forename: Alexis
authors.initials: A
authors.lastname: Lion
authors.affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital of Nancy, Nancy, France Laboratory "Développement, Adaptation et Handicap" (DevAH - EA 3450), University of Lorraine, Vandœuvre-lès-Nancy, France julien.frere@univ-lorraine.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Frère
authors.affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital of Nancy, Nancy, France Laboratory "Développement, Adaptation et Handicap" (DevAH - EA 3450), University of Lorraine, Vandœuvre-lès-Nancy, France.
authors.forename: Philippe P
authors.initials: PP
authors.lastname: Perrin
authors.affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital of Nancy, Nancy, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Beurton
authors.affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital of Nancy, Nancy, France Laboratory "Développement, Adaptation et Handicap" (DevAH - EA 3450), University of Lorraine, Vandœuvre-lès-Nancy, France.
authors.forename: Gérome C
authors.initials: GC
authors.lastname: Gauchard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000150:complications* / Q000601:surgery*; D004856:Postural Balance / Q000502:physiology*; D012678:Sensation Disorders / Q000209:etiology* / Q000601:surgery*; D016896:Treatment Outcome; D014724:Vestibular Function Tests; D055815:Young Adult
keywords: balance control; medical management; neuroplasticity; unilateral vestibular deafferentation; vestibular schwannoma