title: Identification of Catechin, Syringic Acid, and Procyanidin B2 in Wine as Stimulants of Gastric Acid Secretion.
abstract: Organic acids of wine, in addition to ethanol, have been identified as stimulants of gastric acid secretion. This study characterized the influence of other wine compounds, particularly phenolic compounds, on proton secretion. Forty wine parameters were determined in four red wines and six white wines, including the contents of organic acids and phenolic compounds. The secretory activity of the wines was determined in a gastric cell culture model (HGT-1 cells) by means of a pH-sensitive fluorescent dye. Red wines stimulated proton secretion more than white wines. Lactic acid and the phenolic compounds syringic acid, catechin, and procyanidin B2 stimulated proton secretion and correlated with the pro-secretory effect of the wines. Addition of the phenolic compounds to the least active white wine sample enhanced its proton secretory effect by 65 ± 21% (p < 0.05). These results indicate that not only malic and lactic acid but also bitter and astringent tasting phenolic compounds in wine contribute to its stimulatory effect on gastric acid secretion.
authors.forename: Kathrin Ingrid
authors.initials: KI
authors.lastname: Liszt
authors.affiliation: Federal College and Research Institute for Viticulture and Pomology , Klosterneuburg 3400, Austria.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Eder
authors.affiliation: Federal College and Research Institute for Viticulture and Pomology , Klosterneuburg 3400, Austria.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Wendelin
authors.forename: Veronika
authors.initials: V
authors.lastname: Somoza
mesh_terms: D044946:Biflavonoids / Q000032:analysis / Q000378:metabolism*; D002392:Catechin / Q000032:analysis / Q000378:metabolism*; D002460:Cell Line; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D044945:Proanthocyanidins / Q000032:analysis / Q000378:metabolism*; D014920:Wine / Q000032:analysis*
chemical_list: D044946:Biflavonoids; D044945:Proanthocyanidins; C479580:procyanidin B2; D005707:Gallic Acid; D002392:Catechin; C001945:syringic acid
keywords: gastric acid secretion; organic acids; phenolic compounds; red wine; white wine