title: Acute Stress Impairs Self-Control in Goal-Directed Choice by Altering Multiple Functional Connections within the Brain's Decision Circuits.
abstract: Important decisions are often made under stressful circumstances that might compromise self-regulatory behavior. Yet the neural mechanisms by which stress influences self-control choices are unclear. We investigated these mechanisms in human participants who faced self-control dilemmas over food reward while undergoing fMRI following stress. We found that stress increased the influence of immediately rewarding taste attributes on choice and reduced self-control. This choice pattern was accompanied by increased functional connectivity between ventromedial prefrontal cortex (vmPFC) and amygdala and striatal regions encoding tastiness. Furthermore, stress was associated with reduced connectivity between the vmPFC and dorsolateral prefrontal cortex regions linked to self-control success. Notably, alterations in connectivity pathways could be dissociated by their differential relationships with cortisol and perceived stress. Our results indicate that stress may compromise self-control decisions by both enhancing the impact of immediately rewarding attributes and reducing the efficacy of regions promoting behaviors that are consistent with long-term goals.
authors.affiliation: Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, 8006 Zürich, Switzerland. Electronic address: silvia.maier@econ.uzh.ch.
authors.forename: Silvia U
authors.initials: SU
authors.lastname: Maier
authors.affiliation: Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, 8006 Zürich, Switzerland.
authors.forename: Aidan B
authors.initials: AB
authors.lastname: Makwana
authors.affiliation: Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, 8006 Zürich, Switzerland. Electronic address: todd.hare@econ.uzh.ch.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Hare
mesh_terms: D001921:Brain / Q000378:metabolism*; D002755:Choice Behavior / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D006040:Goals; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000378:metabolism*; D009434:Neural Pathways / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology; D013997:Time Factors; D055815:Young Adult