title: Development of Inhibitors of Salicylic Acid Signaling.
abstract: Salicylic acid (SA) plays important roles in the induction of systemic acquired resistance (SAR) in plants. Determining the mechanism of SAR will extend our understanding of plant defenses against pathogens. We recently reported that PAMD is an inhibitor of SA signaling, which suppresses the expression of the pathogenesis-related PR genes and is expected to facilitate the understanding of SA signaling. However, PAMD strongly inhibits plant growth. To minimize the side effects of PAMD, we synthesized a number of PAMD derivatives, and identified compound 4 that strongly suppresses the expression of the PR genes with fewer adverse effects on plant growth than PAMD. We further showed that the adverse effects on plant growth were partially caused the stabilization of DELLA, which is also related to the pathogen responses. These results indicate that compound 4 would facilitate our understanding of SA signaling and its cross talk with other plant hormones.
authors.affiliation: †Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Kai
authors.initials: K
authors.lastname: Jiang
authors.affiliation: †Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kurimoto
authors.affiliation: †Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Eun-kyung
authors.initials: EK
authors.lastname: Seo
authors.affiliation: †Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Miyazaki
authors.affiliation: †Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: †Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Nakamura
authors.affiliation: †Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.|‡CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.|§Department of Biochemistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Tadao
authors.initials: T
authors.lastname: Asami
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism* / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D020231:Colletotrichum / Q000502:physiology; D018506:Gene Expression Regulation, Plant; D010935:Plant Diseases / Q000382:microbiology*; D020156:Salicylic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D029681:Arabidopsis Proteins; D020156:Salicylic Acid
keywords: chemical inhibitor; salicylic acid; signaling pathway; systemic acquired resistance