title: Distinctive Clinical Profile of Blacks Versus Whites Presenting With Sudden Cardiac Arrest.
abstract: BACKGROUND
  Sudden cardiac arrest (SCA) is a major contributor to mortality, but data are limited among nonwhites. Identification of differences in clinical profile based on race may provide opportunities for improved SCA prevention.
  
  
  RESULTS
  In the ongoing Oregon Sudden Unexpected Death Study (SUDS), individuals experiencing SCA in the Portland, OR, metropolitan area were identified prospectively. Patient demographics, arrest circumstances, and pre-SCA clinical profile were compared by race among cases from 2002 to 2012 (for clinical history, n=126 blacks, n=1262 whites). Incidence rates were calculated for cases from the burden assessment phase (2002-2005; n=1077). Age-adjusted rates were 2-fold higher among black men and women (175 and 90 per 100 000, respectively) compared with white men and women (84 and 40 per 100 000, respectively). Compared with whites, blacks were >6 years younger at the time of SCA and had a higher prearrest prevalence of diabetes mellitus (52% versus 33%; P<0.0001), hypertension (77% versus 65%; P=0.006), and chronic renal insufficiency (34% versus 19%; P<0.0001). There were no racial differences in previously documented coronary artery disease or left ventricular dysfunction, but blacks had more prevalent congestive heart failure (43% versus 34%; P=0.04) and left ventricular hypertrophy (77% versus 58%; P=0.02) and a longer QTc interval (466±36 versus 453±41 milliseconds; P=0.03).
  
  
  CONCLUSIONS
  In this US community, the burden of SCA was significantly higher in blacks compared with whites. Blacks with SCA had a higher prearrest prevalence of risk factors beyond established coronary artery disease, providing potential targets for race-specific prevention.
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland.
authors.forename: Kyndaron
authors.initials: K
authors.lastname: Reinier
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Nichols
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland.
authors.forename: Adriana
authors.initials: A
authors.lastname: Huertas-Vazquez
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland.
authors.forename: Audrey
authors.initials: A
authors.lastname: Uy-Evanado
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland.
authors.forename: Carmen
authors.initials: C
authors.lastname: Teodorescu
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Stecker
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland.
authors.forename: Karen
authors.initials: K
authors.lastname: Gunson
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Jui
authors.affiliation: From The Heart Institute, Cedars-Sinai Medical Center, Los Angeles CA (K.R., A.H.-V., A.U.-E., C.T., S.S.C.); Kaiser Permanente Center for Health Research, Portland, OR (G.A.N.); and Knight Cardiovascular Institute (E.C.S.), Department of Pathology (K.G.), and Department of Emergency Medicine (J.J.), Oregon Health and Science University, Portland. sumeet.chugh@cshs.org.
authors.forename: Sumeet S
authors.initials: SS
authors.lastname: Chugh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044383:Black People / Q000208:ethnology* / Q000706:statistics & numerical data; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000208:ethnology* / Q000209:etiology; D048909:Diabetes Complications / Q000150:complications / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology / Q000208:ethnology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009922:Oregon; D015995:Prevalence; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000453:epidemiology / Q000208:ethnology; D012189:Retrospective Studies; D012307:Risk Factors; D044465:White People / Q000208:ethnology* / Q000706:statistics & numerical data; D001741:Black or African American
keywords: death; diabetes mellitus; hypertension; hypertrophy; left ventricular; risk factors; sudden