title: Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research.
abstract: The study of the three protagonists in malaria-the Plasmodium parasite, the Anopheles mosquito, and the human host-is key to developing methods to control and eventually eliminate the disease. Genomic technologies, including the recent development of next-generation sequencing, enable interrogation of this triangle to an unprecedented level of scrutiny, and promise exciting progress toward real-time epidemiology studies and the study of evolutionary adaptation. We discuss the use of genomics by the International Centers of Excellence for Malaria Research, a network of field sites and laboratories in malaria-endemic countries that undertake cutting-edge research, training, and technology transfer in malarious countries of the world.
authors.forename: Jane M
authors.initials: JM
authors.lastname: Carlton
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Volkman
authors.forename: Swapna
authors.initials: S
authors.lastname: Uplekar
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Hupalo
authors.forename: João Marcelo
authors.initials: JM
authors.lastname: Pereira Alves
authors.forename: Liwang
authors.initials: L
authors.lastname: Cui
authors.forename: Martin
authors.initials: M
authors.lastname: Donnelly
authors.forename: David S
authors.initials: DS
authors.lastname: Roos
authors.forename: Omar S
authors.initials: OS
authors.lastname: Harb
authors.forename: Monica
authors.initials: M
authors.lastname: Acosta
authors.forename: Andrew
authors.initials: A
authors.lastname: Read
authors.forename: Paulo E M
authors.initials: PEM
authors.lastname: Ribolla
authors.forename: Om P
authors.initials: OP
authors.lastname: Singh
authors.forename: Neena
authors.initials: N
authors.lastname: Valecha
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Wassmer
authors.forename: Marcelo
authors.initials: M
authors.lastname: Ferreira
authors.forename: Ananias A
authors.initials: AA
authors.lastname: Escalante
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005828:Genetics, Population / Q000379:methods; D055106:Genome-Wide Association Study; D060005:Genotyping Techniques; D006801:Humans; D007391:International Cooperation; D008288:Malaria / Q000453:epidemiology / Q000235:genetics* / Q000469:parasitology / Q000517:prevention & control; D018895:Microsatellite Repeats / Q000235:genetics; D010961:Plasmodium / Q000235:genetics*; D010963:Plasmodium falciparum / Q000235:genetics; D010966:Plasmodium vivax / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D005819:Genetic Markers