title: Splenomegaly in Sarcoidosis: Frequency, Treatment, Prognosis and Long-term Follow-up.
abstract: BACKGROUND
  The splenic involvement is common in sarcoidosis, but its real frequency is still obscure depending doubtless on the method of splenomegaly detection. Splenomegaly may be accompanied with pain or anemia, leucopenia and thrombocytopenia.
  
  
  OBJECTIVE
  The aim of this study was to investigate the frequency of splenomegaly related to clinical characteristics of sarcoidosis and to solve the dilemma--whether to introduce medicaments, and when to perform splenectomy.
  
  
  METHODS
  The method of the study is a retrospective and prospective analysis of the patients'material.
  
  
  RESULTS
  The study included 540 patients with sarcoidosis in a 20-year period. Of them, 26% had splenomegaly detected by computerized tomography screening. Splenomegaly was more frequently registered in the patients with a longer history of sarcoidosis (38%), as compared to those with a shorter history of the disease (23%) (p < 0.05). Splenomegaly was more frequently registered in the patients with other extrapulmonary lesions detected (33%) than in those who had no extrapulmonary manifestations of sarcoidosis (17%) (p < 0.01). Indications, possible benefits and complications of splenectomy were analysed in 11 sarcoidosis patients undergoing this intervention for various reasons, of which the follow-up period ranged from one to 20 years.
  
  
  CONCLUSIONS
  Splenomegaly was more frequent in chronic cases or in the patients with established sarcoid lesions of other extrapulmonary organs.The primary treatment of uncomplicated symptomatic splenic sarcoidosis includes medicamentous therapy. Occasionally, splenectomy is required. Prognostically, splenomegaly indicates an unfavorable course of the disease.
authors.forename: Zora
authors.initials: Z
authors.lastname: Pavlović-Popović
authors.forename: Bojan
authors.initials: B
authors.lastname: Zarić
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Kosjerina
authors.forename: Dragana
authors.initials: D
authors.lastname: Petrović
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D013163:Splenomegaly / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy