title: Management of endocrine disease: Diabetes and osteoporosis: cause for concern?
abstract: Diabetes and osteoporosis are both frequent conditions, and they may thus occur simultaneously by chance. However, a growing body of evidence suggests that hyperglycemia may impair bone matrix formation and biochemical competence. Decreased biomechanical competence may be present even in a setting of increased bone mineral density, as assessed by traditional dual energy X-ray absorptiometry or normal structural parameters by quantitative computed tomography. Also, the absence of endogenous insulin secretion in type 1 diabetes (T1D) and insulin resistance or, in some cases, frank hyperinsulinemia in T2D may play a role.
authors.affiliation: Department of Clinical MedicineAalborg University Hospital, Mølleparkvej 4, DK-9100 Aalborg, DenmarkDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus, DenmarkDepartment of EndocrinologyMedicinerhuset, Aalborg University Hospital, Mølleparkvej 4, DK-9100 Aalborg, Denmark Department of Clinical MedicineAalborg University Hospital, Mølleparkvej 4, DK-9100 Aalborg, DenmarkDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus, DenmarkDepartment of EndocrinologyMedicinerhuset, Aalborg University Hospital, Mølleparkvej 4, DK-9100 Aalborg, Denmark.
authors.forename: Jakob
authors.initials: J
authors.lastname: Starup-Linde
authors.affiliation: Department of Clinical MedicineAalborg University Hospital, Mølleparkvej 4, DK-9100 Aalborg, DenmarkDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus, DenmarkDepartment of EndocrinologyMedicinerhuset, Aalborg University Hospital, Mølleparkvej 4, DK-9100 Aalborg, Denmark Department of Clinical MedicineAalborg University Hospital, Mølleparkvej 4, DK-9100 Aalborg, DenmarkDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus, DenmarkDepartment of EndocrinologyMedicinerhuset, Aalborg University Hospital, Mølleparkvej 4, DK-9100 Aalborg, Denmark p-vest@post4.tele.dk.
authors.forename: Peter
authors.initials: P
authors.lastname: Vestergaard
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism; D006946:Hyperinsulinism / Q000150:complications / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D010024:Osteoporosis / Q000150:complications / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin