title: Moderate exercise training is more effective than resveratrol supplementation for ameliorating lipid metabolic complication in skeletal muscle of high fat diet-induced obese mice.
abstract: OBJECTIVE
  The aim of this study was to compare the effectiveness of moderate exercise training or resveratrol supplementation with a low fat diet on lipid metabolism in the skeletal muscle of high fat diet-induced obese mice.
  
  
  METHODS
  C57BL/6J mice (5 weeks old, n = 30) were fed a high fat diet (45% fat) for 8 weeks first to make them obese. Afterward, all the mice were fed a low fat diet during 8 weeks of intervention with moderate exercise training and resveratrol supplementation. Before the intervention, the mice were separated into 3 groups: low-fat diet control (HLC; n = 10), low fat diet with resveratrol (HLR; n = 10) or low fat diet with exercise (HLE n = 10). The exercise group (HLE) performed treadmill running for 30-60 min/day at 10-22 m/min, 0% grade, 5 times/week for 8 weeks, while the resveratrol group (HLR) received a daily dose of resveratrol (10 mg/kg of body weight), 5 days/week for 8 weeks.
  
  
  RESULTS
  Body weight was significantly reduced in HLE. Further, the lipogenesis marker SREBP and the inflammatory cytokine TNF-α were significant reduced in HLE. However, there was no significant effect from resveratrol supplementation with a low fat diet. Taken together, exercise training with a low fat diet has the positive effect of ameliorating lipid disturbance in the skeletal muscle of high fat diet-induced obese mice.
  
  
  CONCLUSIONS
  These findings suggest that exercise training with a low fat diet is most effective to improve lipid metabolism by reducing lipogenesis and inflammation in the skeletal muscle of high fat diet-induced obese mice.
authors.affiliation: Department of Sport Science, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Jun Hyun
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Sport Science, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Hee Geun
authors.initials: HG
authors.lastname: Park
authors.affiliation: Department of Sport Science, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Young Ran
authors.initials: YR
authors.lastname: Lee
authors.affiliation: Department of Sport Science, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Wang Lok
authors.initials: WL
authors.lastname: Lee
keywords: Exercise; High fat diet; Inflammation; Lipogenesis; Lipolysis; Obese; Resveratrol