title: Next revolution in molecular theranostics: personalized medicine for urologic cancers.
abstract: Extensive lists of molecular biomarkers are currently evaluated as potential targets for directed cancer therapies. We reviewed three potential candidate biomarkers to play a role in the near future as molecular theranostics for urologic malignancies. Carbonic anhydrase type IX is a surrogate marker of hypoxia highly expressed in cancer cells. Their expression and clinical significance in kidney and urothelial bladder cancer are discussed as well as the main therapeutic approaches that are currently under evaluation. For prostate cancer, available evidence on the use of prostate-specific membrane antigen and neuropeptide receptors radiolabeled analog and the undergoing clinical studies are also analyzed and discussed at different stages of prostate cancer.
authors.affiliation: Université Libre de Bruxelles, 50 Franklin Roosevelt Avenue, 1050 Brussels, Belgium.|Jules Bordet Institute, 121 Boulevard de Waterloo, 1000 Brussels, Belgium.
authors.forename: Fouad
authors.initials: F
authors.lastname: Aoun
authors.affiliation: Université Libre de Bruxelles, 50 Franklin Roosevelt Avenue, 1050 Brussels, Belgium.|Jules Bordet Institute, 121 Boulevard de Waterloo, 1000 Brussels, Belgium.
authors.forename: Hampig Raphael
authors.initials: HR
authors.lastname: Kourie
authors.affiliation: Université Libre de Bruxelles, 50 Franklin Roosevelt Avenue, 1050 Brussels, Belgium.|Jules Bordet Institute, 121 Boulevard de Waterloo, 1000 Brussels, Belgium.
authors.forename: Carlos
authors.initials: C
authors.lastname: Artigas
authors.affiliation: Université Libre de Bruxelles, 50 Franklin Roosevelt Avenue, 1050 Brussels, Belgium.
authors.forename: Thierry
authors.initials: T
authors.lastname: Roumeguère
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics; D000954:Antigens, Surface / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases / Q000235:genetics; D043425:Glutamate Carboxypeptidase II / Q000235:genetics; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D008297:Male; D057285:Precision Medicine; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D018013:Receptors, Neuropeptide / Q000235:genetics; D000068936:Theranostic Nanomedicine; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D014408:Biomarkers, Tumor; D018013:Receptors, Neuropeptide; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases
keywords: PSMA; bombesin; carbonic anhydrase; kidney cancer; neurotensin; prostate cancer; theranostics