title: Real-time monitoring in vivo behaviors of theranostic nanoparticles by contrast-enhanced T1 imaging.
abstract: The innovative applications of engineered nanoparticles (NPs) in medicine, such as diagnosis and therapy, have attracted considerable attention. It is highly important to predict the interactions between engineered NPs and the complex biological system as well as the impacts on the subsequent behaviors in living subjects. Herein, we report the use of T1 contrast-enhanced magnetic resonance imaging (MRI) to monitor the in vivo behaviors of NPs in a real-time manner. We chose ultrasmall Pd nanosheets (SPNSs) as the object of NPs because of their promise in theranostics and fitness for diverse surface chemistry. SPNSs were modified with different surface coating ligands (e.g., polyethylene glycol, zwitterionic ligands, polyethylenimine) and functionalized with Gd-chelates to render T1 contrast-enhanced capability. MRI real-time monitoring recorded the location and accumulation of SPNSs in small animals and revealed the prominent roles of surface coating ligands in pharmacokinetics. These results highlighted the significance of selecting proper surface coating for particular biomedical assignment. Moreover, we demonstrated a powerful and noninvasive means to predict and detect the behaviors of NPs in living subjects, which may be helpful for rational design and screening of engineered NPs in biomedical applications.
authors.affiliation: State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital, Xiamen University , Xiamen, Fujian 361004, China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Chi
authors.affiliation: Department of Electronic Science and Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Jiahe
authors.initials: J
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Wang
authors.affiliation: Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital, Xiamen University , Xiamen, Fujian 361004, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Electronic Science and Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Jinhao
authors.initials: J
authors.lastname: Gao
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D009374:Neoplasms, Experimental / Q000175:diagnosis* / Q000628:therapy; D010165:Palladium / Q000008:administration & dosage / Q000737:chemistry*; D010789:Phototherapy; D000068936:Theranostic Nanomedicine; D013997:Time Factors
chemical_list: D003287:Contrast Media; D010165:Palladium