title: Effects of prenatal exposure to valproic acid on the development of juvenile-typical social play in rats.
abstract: Autism is a severe neurodevelopmental disorder characterized by qualitative impairments in social behavior, communication, and aberrant repetitive behaviors. A major focus of animal models of autism has been to mimic the social deficits of the disorder. The present study assessed whether rats exposed prenatally to valproic acid (VPA) show deficits in social play as juveniles that are consistent with the social deficits observed in autism. Dams were exposed to an acute dose of VPA on gestational day 12.5. Later, the playful interactions and associated ultrasonic vocalizations of the juveniles were examined. It was predicted that VPA-treated rats should play less than the controls. Characteristic of neurobehavioral insult at this early age, the VPA-treated juveniles showed significant increases in the frequency of body shakes and sexual mounting, but played at the same frequency as the controls. However, when playing, they were less likely to use tactics that facilitated bodily contact and vocalized less. These data suggest that prenatal VPA exposure disrupts some aspects of being able to communicate effectively and engage partners in dynamic interactions - deficits that are consistent with those observed in autism.
authors.affiliation: aDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta bCanadian Institute for Advanced Research Program in Child Brain Development, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Raza
authors.forename: Brett T
authors.initials: BT
authors.lastname: Himmler
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Himmler
authors.forename: Allonna
authors.initials: A
authors.lastname: Harker
authors.forename: Bryan
authors.initials: B
authors.lastname: Kolb
authors.forename: Sergio M
authors.initials: SM
authors.lastname: Pellis
authors.forename: Robbin
authors.initials: R
authors.lastname: Gibb
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D003142:Communication; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D010988:Play and Playthings; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D020318:Rats, Long-Evans; D012920:Social Behavior Disorders / Q000139:chemically induced; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D014635:Valproic Acid