title: Cannabis, Cannabinoids, and Cerebral Metabolism: Potential Applications in Stroke and Disorders of the Central Nervous System.
abstract: No compound has generated more attention in both the scientific and recently in the political arena as much as cannabinoids. These diverse groups of compounds referred collectively as cannabinoids have both been vilified due to its dramatic and potentially harmful psychotropic effects and glorified due to its equally dramatic and potential application in a number of acute and chronic neurological conditions. Previously illegal to possess, cannabis, the plant where natural form of cannabinoids are derived, is now accepted in a growing number of states for medicinal purpose, and some even for recreational use, increasing opportunities for more scientific experimentation. The purpose of this review is to summarize the growing body of literature on cannabinoids and to present an overview of our current state of knowledge of the human endocannabinoid system in the hope of defining the future of cannabinoids and its potential applications in disorders of the central nervous system, focusing on stroke.
authors.affiliation: Neurocritical Care Division, Department of Neurology and Neurosurgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA, latorrej@upstate.edu.
authors.forename: Julius Gene S
authors.initials: JG
authors.lastname: Latorre
authors.forename: Elena B
authors.initials: EB
authors.lastname: Schmidt
mesh_terms: D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids / Q000009:adverse effects / Q000627:therapeutic use*; D002188:Cannabis / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D006801:Humans; D064086:Medical Marijuana / Q000009:adverse effects / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008517:Phytotherapy; D020521:Stroke / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D064086:Medical Marijuana; D018696:Neuroprotective Agents