title: [Triple synchronous primary gynaecological tumours. A case report].
abstract: BACKGROUND
  Synchronous multiple primary malignancies in the female genital tract are infrequent. From 50 to 70% of them corresponds to synchronous cancers of the endometrium and ovary. To our knowledge, this is only the third case report in the international literature of three concurrent gynaecological cancers of epithelial origin. A case is presented, as well as a literature review due to the infrequency of its diagnosis and the lack of information on the subject.
  
  
  METHODS
  A 49-year-old woman, with previous gynaecological history of ovarian endometriosis. She underwent a hysterectomy and bilateral oophorectomy, as she had been diagnosed with endometrial hyperplasia with atypia. The final histopathology reported synchronous ovarian, Fallopian tube, and endometrial cancer. An extension study and complete surgical staging was performed, both being negative. She received adjuvant treatment of chemotherapy and radiotherapy. She is currently free of disease.
  
  
  CONCLUSIONS
  The aetiology is uncertain. There is controversy relating to increased susceptibility of synchronous neoplasms to pelvic endometriosis and inherited genetic syndromes. Its diagnosis needs to differentiate them from metastatic disease. Additionally, they are problematical from a clinical, diagnostic, therapeutic, and prognostic point of view. The presentation of more cases of triple synchronous cancers is necessary for a complete adjuvant and surgical treatment.
authors.affiliation: Servicio de Ginecología y Obstetricia, Hospital Universitario Virgen de Valme, Sevilla, España. Electronic address: lauragp83@hotmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Gutiérrez-Palomino
authors.affiliation: Servicio de Ginecología y Obstetricia, Hospital Universitario Virgen de Valme, Sevilla, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Romo-de Los Reyes
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario Virgen de Valme, Sevilla, España.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Pareja-Megía
authors.affiliation: Servicio de Ginecología y Obstetricia, Hospital Universitario Virgen de Valme, Sevilla, España.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: García-Mejido
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D018269:Carcinoma, Endometrioid / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D005185:Fallopian Tube Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D010049:Ovarian Diseases / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D010052:Ovariectomy; D017239:Paclitaxel / Q000008:administration & dosage; D018714:Radiotherapy, Adjuvant; D058994:Salpingectomy; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery
chemical_list: D017239:Paclitaxel; D002945:Cisplatin
keywords: Cáncer de endometrio; Cáncer de ovario; Cáncer tubular; Endometrial cancer; Fallopian tube cancer; Multiple synchronous cancers; Neoplasias sincrónicas; Neoplasias sincrónicas múltiples; Ovarian cancer; Synchronous cancers