title: Contribution of CD24 polymorphisms to autoimmune disease: A meta-analysis.
abstract: OBJECTIVE
  To determine the relationship between two CD24 polymorphisms, rs8734/rs52812045 and rs3838646, and autoimmune disease.
  
  
  METHODS
  Meta-analysis.
  
  
  METHODS
  The Medline, EMBASE, Web of Science, and Cochrane Library databases were searched for studies reporting the association between CD24 polymorphisms and autoimmune disease. Two of the authors selected eligible studies and extracted and analyzed the data independently.
  
  
  RESULTS
  Compared with carriers of the C allele (CC, CT, CT+CC), individuals homozygous for the T allele (TT) and heterozygous (CT+TT) at rs8734/rs52812045 have a higher incidence of autoimmune disease, whereas rs3838646 is not associated with autoimmune disease. Subgroup analysis found an increased risk of multiple sclerosis with the TT vs. CC, TT vs. CT, and TT vs. CC+CT alleles.
  
  
  CONCLUSIONS
  The CD24 polymorphism rs8734/rs52812045 contributes to the development of autoimmune disease.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Jihae
authors.initials: J
authors.lastname: Baek
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Soowon
authors.initials: S
authors.lastname: Kang
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Byeon
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Kwang
authors.initials: K
authors.lastname: Woo Hwang
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Min
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics*; D051927:CD24 Antigen / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human
keywords: Autoimmune disease; CD24; Genetic variants; Meta-analysis; Polymorphism