title: Risk factors for the development of metachronous bone metastasis in colorectal cancer patients after curative resection.
abstract: OBJECTIVE
  Metachronous bone metastasis (MBM) occurs in 6-10% of colorectal cancer (CRC) patients following surgical treatment. The aim of this study is to determine the risk factors affecting the development of MBM in CRC patients following curative resection.
  
  
  METHODS
  Clinical and pathological records of 516 CRC patients who underwent curative resection were retrospectively studied. The association between clinicopathological variables and development of MBM was investigated using univariate and multivariate analyses.
  
  
  RESULTS
  The incidence of MBM was 6.0% and the median time of developing MBM was 15 (range, 1-89) months. Univariate analysis identified that lymph node involvement (p = 0.001), tumor stage (p = 0.020) and tumor location (p = 0.015) were significantly correlated with development of MBM. Multivariate analyses showed tumor location (p = 0.039) and lymph node involvement (p = 0.003) were independent risk factors contributing to the occurrence of MBM.
  
  
  CONCLUSIONS
  This study indicated that tumor location and lymph node involvement were independent risk factors for development of MBM in CRC patients after curative resection.
authors.affiliation: Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China. Electronic address: sunchangdoc@163.com.
authors.forename: Chang
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China. Electronic address: dymrsd@126.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China. Electronic address: haiyangzhou84@126.com.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China. Electronic address: huzq62@126.com.
authors.forename: Zhi Qian
authors.initials: ZQ
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Colorectal cancer; Metachronous bone metastasis; Risk factor; Surgical resection