title: CD7 aberrant expression led to a lineage switch at relapsed childhood acute pre-B lymphoblastic leukemia.
abstract: Immunophenotypic changes and lineage switch between diagnosis and relapse in acute lymphoblastic leukemia are uncommon and accompanied by poor outcomes. In this report, a 12-year-old boy with diagnosis of pre-B ALL with an aberrant expression of CD 7 is described. Patient was treated with the ALL-BFM 2000 protocol and suffered an episode of relapse with a lineage switch from pre-B ALL to T cell ALL. This report concludes that presence of aberrant expression of CD7 at diagnosis of pre-B ALL can have prognostic value of lineage switch to T cell ALL at relapse.
authors.affiliation: Research Department, Mahak's Pediatric Cancer Treatment and Research Center, Mahak Blvd., Oshan Blvd., Aghdasieh Ave, 1956993461, Tehran, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Fallah Azad
authors.affiliation: Research Department, Mahak's Pediatric Cancer Treatment and Research Center, Mahak Blvd., Oshan Blvd., Aghdasieh Ave, 1956993461, Tehran, Iran.
authors.forename: Amir Abbas
authors.initials: AA
authors.lastname: Hedayati Asl
authors.affiliation: Mahak's Pediatric Cancer Treatment and Research Center, Islamic Azad University of Qom, Qom, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Tashvighi
authors.affiliation: Research Department, Mahak's Pediatric Cancer Treatment and Research Center, Mahak Blvd., Oshan Blvd., Aghdasieh Ave, 1956993461, Tehran, Iran. naghmeh.niktorehmofrad@gmail.com.
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Niktoreh Mofrad
authors.affiliation: Research Department, Mahak's Pediatric Cancer Treatment and Research Center, Mahak Blvd., Oshan Blvd., Aghdasieh Ave, 1956993461, Tehran, Iran.
authors.forename: Mansoureh
authors.initials: M
authors.lastname: Haghighi
authors.affiliation: Mahak's Pediatric Cancer Treatment and Research Center, Army Medical Science University, Tehran, Iran.
authors.forename: Azim
authors.initials: A
authors.lastname: Mehrvar
mesh_terms: D019011:Antigens, CD7 / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D006801:Humans; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D012008:Recurrence
chemical_list: D019011:Antigens, CD7
keywords: Lineage switch; Lymphoblastic leukemia; Neoplasm antigens; Recurrence