title: Breast Cancer Risk and Follow-up Recommendations for Young Women Diagnosed with Atypical Hyperplasia and Lobular Carcinoma In Situ (LCIS).
abstract: BACKGROUND
  The risk of breast cancer in young women diagnosed with atypical hyperplasia and (LCIS) is not well defined. The objectives were to evaluate outcomes and to help determine guidelines for follow-up in this population.
  
  
  METHODS
  A retrospective review of women under age 35 diagnosed with ADH, ALH, LCIS, and severe ADH from 1987 to 2010 was performed. Patient characteristics, pathology and follow-up were determined from chart review.
  
  
  RESULTS
  We identified 58 young women with atypical breast lesions. Median age at diagnosis was 31 years (range 19-34). 34 patients had ADH, 11 had ALH, 8 had LCIS, and 5 had severe ADH. 7 (12%) patients developed breast cancer. The median follow-up was 86 months (range 1-298). Median time to cancer diagnosis was 90 months (range 37-231). 4 cancers were on the same side, 3 were contralateral. 4 were IDC, 1 was ILC, and 2 were DCIS. Cancer was detected by screening mammogram in 4 patients, 2 by clinical exam, and 1 unknown. In the entire cohort, 26 (45%) patients had screening mammograms as part of their follow up, 12 patients had only clinical follow up, and 20 had no additional follow up. 13 patients required subsequent biopsies.
  
  
  CONCLUSIONS
  Young women with atypical breast lesions are at a markedly increased risk for developing breast cancer and should be followed closely. Based on our findings, we recommend close clinical follow-up, MRI starting at age 25 through age 29, and screening mammograms for those over 30 in this high-risk group of patients.
authors.affiliation: Department of Surgical Oncology-Breast Surgery Division, Massachusetts General Hospital, Boston, MA, USA, mcevoy.maureen@gmail.com.
authors.forename: Maureen P
authors.initials: MP
authors.lastname: McEvoy
authors.forename: Suzanne B
authors.initials: SB
authors.lastname: Coopey
authors.forename: Emanuele
authors.initials: E
authors.lastname: Mazzola
authors.forename: Julliette
authors.initials: J
authors.lastname: Buckley
authors.forename: Ahmet
authors.initials: A
authors.lastname: Belli
authors.forename: Fernanda
authors.initials: F
authors.lastname: Polubriaginof
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Merrill
authors.forename: Rong
authors.initials: R
authors.lastname: Tang
authors.forename: Judy E
authors.initials: JE
authors.lastname: Garber
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Smith
authors.forename: Michele A
authors.initials: MA
authors.lastname: Gadd
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Specht
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Guidi
authors.forename: Constance A
authors.initials: CA
authors.lastname: Roche
authors.forename: Keven S
authors.initials: KS
authors.lastname: Hughes
mesh_terms: D000328:Adult; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D003266:Continuity of Patient Care; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008327:Mammography; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult