title: Therapy of Severe Heatshock in Combination With Multiple Organ Dysfunction With Continuous Renal Replacement Therapy: A Clinical Study.
abstract: This study aimed to compare the clinical effects of continuous renal replacement therapy (CRRT) and routine therapy in heatshock (HS) patients.We retrospectively reviewed the clinical information of 33 severe exertional HS patients who were treated from February 1998 to October 2013. On the basis of whether or not CRRT therapy was used in addition to conventional therapy, patients were divided into a CRRT group (n = 15) and a control group (n = 18). Body temperature, blood gas analysis, routine blood tests, blood eletrolytes, enzymes and kidney function data, and APACHE II scores were obtained and compared between the 2 groups on admission and 3, 5, and 7 days after admission. Mortality was also compared between the 2 groups.CRRT treatment combined with conventional treatment resulted in a higher hospital-discharge rate, a faster return to normal of body temperature, greater increase in platelets, a greater decrease in WBC, neutrophils, and serum markers for liver and kidney dysfunction, greater improvement of organ dysfunction, and lower APACHE II scores than conventional treatment used alone.The addition of CRRT to conventional treatment for HS improves survival and causes a faster return to normal of serum markers and organ function.
authors.affiliation: From the Department of Pediatrics, Fuzhou General Hospital of Nanjing Military Command, PLA (G-MC); Department of Nephrology, Fuzhou General Hospital of Nanjing Military Command, PLA (Y-HC, JC); Department of Emergency, Fuzhou General Hospital of Nanjing Military Command, PLA (WZ); Department of Hemodialysis room, Fuzhou General Hospital of Nanjing Military Command, PLA (YY); Statistics Room, Fuzhou General Hospital of Nanjing Military Command, PLA (J-HC); and Clinical Medical College of Fujian Medical University in Fuzhou General Hospital of Nanjing Military Command, PLA (G-MC, Y-HC, WZ, YY, J-HC, JC); Dongfang Hospital Affiliated to Xiamen University, Fuzhou, China (G-MC, Y-HC, WZ, YY, J-HC, JC).
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Chen
authors.forename: Yang-Hong
authors.initials: YH
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Yu
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D018883:Heat Stroke / Q000150:complications / Q000401:mortality / Q000628:therapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D017582:Renal Replacement Therapy / Q000379:methods; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult