title: New era for management of chronic hepatitis C virus using direct antiviral agents: A review.
abstract: The pegylated interferon regimen has long been the lone effective management of chronic hepatitis C with modest response. The first appearance of protease inhibitors included boceprevir and telaprevir. However, their efficacy was limited to genotype 1. Recently, direct antiviral agents opened the gate for a real effective management of HCV, certainly after FDA approval of some compounds that further paved the way for the appearance of enormous potent direct antiviral agents that may achieve successful eradication of HCV.
authors.affiliation: Endemic Medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Tamer
authors.initials: T
authors.lastname: Elbaz
authors.affiliation: Hepatology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Kassas
authors.affiliation: Endemic Medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Gamal
authors.initials: G
authors.lastname: Esmat
keywords: Direct antiviral agents (DAA); HCV; Polymerase inhibitors; Protease inhibitors