title: Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance.
abstract: Dehydrogenase/reductase (SDR family) member 9 (DHRS9) is aberrantly expressed in colorectal cancer (CRC), but its prognostic value is unknown. The aim of the work was to investigate the prognostic significance of DHRS9 expression in CRC. We found that DHRS9 was frequently downregulated in CRC clinical samples at both the messenger RNA (mRNA) and protein levels. Decreased expression of DHRS9 was significantly correlated with increased lymph node metastasis (p = 0.032), advanced tumor-node-metastasis (TNM) stage (p = 0.021), increased disease recurrence (p = 0.001), and death (p = 0.014). Kaplan-Meier analysis indicated that low DHRS9 expression predicted poor disease-free survival (p = 0.003) and disease-specific survival (p = 0.021). Cox multivariate analysis revealed that reduced expression of DHRS9 was an independent unfavorable prognostic indicator for CRC. Furthermore, combination of DHRS9 with TNM stage was a more powerful predictor of poor prognosis than either of the two parameters alone. Our results suggest that decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic biomarker in CRC.
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. lianghudoc@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Oncology, 150th Hospital of PLA, Luoyang, China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Chen
authors.affiliation: Department of Oncology, Cancer Center of People's Liberation Army, General Hospital of Shenyang Military Region, Shenyang, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of Clinical Laboratory, 150th Hospital of PLA, Luoyang, China.
authors.forename: Guang-Zhen
authors.initials: GZ
authors.lastname: Yang
authors.affiliation: Department of Oncology, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Feng
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China.
authors.forename: Chen-Ye
authors.initials: CY
authors.lastname: Qi
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gong
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Zhai
authors.affiliation: Department of Gastrointestine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China. caiqingpingwcwk@163.com.
authors.forename: Qing-Ping
authors.initials: QP
authors.lastname: Cai
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. chunfgao@163.com.
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Gao
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D018572:Disease-Free Survival; D015536:Down-Regulation; D005260:Female; D005500:Follow-Up Studies; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D015096:3-Hydroxysteroid Dehydrogenases; C432414:DHRS9 protein, human
keywords: Biomarker; Colorectal cancer; DHRS9; Prognosis; Survival