title: Cerebral Perfusion Measurements in Elderly with Hypertension Using Arterial Spin Labeling.
abstract: OBJECTIVE
  The current study assesses the feasibility and value of crushed cerebral blood flow (CBFcrushed) and arterial transit time (ATT) estimations for large clinical imaging studies in elderly with hypertension.
  
  
  METHODS
  Two pseudo-continuous arterial spin labeling (ASL) scans with (CBFcrushed) and without flow crushers (CBFnon-crushed) were performed in 186 elderly with hypertension, from which CBF and ATT maps were calculated. Standard flow territory maps were subdivided into proximal, intermediate and distal flow territories, based on the measured ATT. The coefficient of variation (CV) and physiological correlations with age and gender were compared between the three perfusion parameters.
  
  
  RESULTS
  There was no difference in CV between CBFcrushed and CBFnon-crushed (15-24%, p>0.4) but the CV of ATT (4-9%) was much smaller. The total gray matter correlations with age and gender were most significant with ATT (p = .016 and p<.001 respectively), in between for CBFcrushed (p = .206 and p = .019) and least significant for CBFnon-crushed (p = .236 and p = .100).
  
  
  CONCLUSIONS
  These data show the feasibility and added value of combined measurements of both crushed CBF and ATT for group analyses in elderly with hypertension. The obtained flow territories provide knowledge on vascular anatomy of elderly with hypertension and can be used in future studies to investigate regional vascular effects.
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: H J M M
authors.initials: HJ
authors.lastname: Mutsaerts
authors.affiliation: Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: van Dalen
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: D F R
authors.initials: DF
authors.lastname: Heijtel
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: P F C
authors.initials: PF
authors.lastname: Groot
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: C B L M
authors.initials: CB
authors.lastname: Majoie
authors.affiliation: Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
authors.forename: E T
authors.initials: ET
authors.lastname: Petersen
authors.affiliation: Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Richard
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Nederveen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D002536:Cerebral Arteries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005240:Feasibility Studies; D005260:Female; D066128:Gray Matter / Q000098:blood supply; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013113:Spin Labels; D013382:Subtraction Technique
chemical_list: D013113:Spin Labels