title: Frontiers in Therapy of Treatment-Resistant-Depression: A Future Role of Ketamine?
abstract: Many patients treated for major depression in mental health and primary care settings fail to respond to adequate trials of available evidence-based treatments. Antidepressants, psychotherapy, and brain stimulation therapies have had some success, but many individuals do not respond to these treatments. Ketamine, a dissociative general anesthetic agent, is emerging as an unexpected possible future treatment to help individuals who suffer from refractory major depression.
authors.forename: Spencer
authors.initials: S
authors.lastname: Kwak
authors.forename: David
authors.initials: D
authors.lastname: Tiller
authors.forename: Phebe
authors.initials: P
authors.lastname: Tucker
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D061218:Depressive Disorder, Treatment-Resistant / Q000188:drug therapy*; D006801:Humans; D007649:Ketamine / Q000494:pharmacology / Q000627:therapeutic use*; D011320:Primary Health Care; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D007649:Ketamine