title: Inhibitory effect of group II mGluR agonist 2R, 4R-APDC on cell proliferation in dentate gyrus in rats with epileptic seizure.
abstract: OBJECTIVE
  Epileptic seizure can increase the cell proliferation in dentate gyrus in brain, but the mechanism remains unclear.
  
  
  METHODS
  In this study, using systemic bromodeoxyuridine (BrdU) to label the dividing cells, the inhibitory effect of group II metabotropic glutamate receptor (mGluR) agonist 2R, 4R-4-aminopyrrolidine-2, 4-dicarboxylate (2R, 4R-APDC) on cell proliferation in dentate gyrus in rats after pilocarpine-induced status epilepticus (SE) was investigated.
  
  
  RESULTS
  Results found that, 2R, 4R-APDC could significantly inhibit the behavioral seizure and block the seizure-induced increase of BrdU-positive cells in dentate gyrus, especially in hilus. Double-label immunofluorescence staining showed that, 2R, 4R-APDC did not affect the ability of newborn cells to differentiate into neurons or astrocytes.
  
  
  CONCLUSIONS
  2R, 4R-APDC not only has anticonvulsant effect on adult rats with pilocarpine-induced SE, but also has neuroprotective effect by reducing the abnormal regeneration of nerves.
authors.affiliation: Department of Geriatrics, Provincial Hospital Affiliated to Shandong University, Jinan, China. yabofeng@163.com.
authors.forename: H
authors.initials: H
authors.lastname: Yao
authors.forename: Y-B
authors.initials: YB
authors.lastname: Feng
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Pang
authors.forename: J-J
authors.initials: JJ
authors.lastname: Xu
authors.forename: B-X
authors.initials: BX
authors.lastname: Yu
authors.forename: X-P
authors.initials: XP
authors.lastname: Liu
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D049109:Cell Proliferation / Q000187:drug effects*; D018891:Dentate Gyrus / Q000187:drug effects* / Q000473:pathology; D004827:Epilepsy / Q000188:drug therapy* / Q000473:pathology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*
chemical_list: C097299:4-aminopyrrolidine-2,4-dicarboxylic acid; D000927:Anticonvulsants; D018690:Excitatory Amino Acid Agonists; D018696:Neuroprotective Agents; D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; D011392:Proline