title: Perfluoroalkyl acid (PFAA) levels and profiles in breast milk, maternal and cord serum of French women and their newborns.
abstract: One major concern regarding perfluoroalkyl acids (PFAAs) is their potential role in onset of health troubles consecutive to early exposure during the perinatal period. In the present work, the internal exposure levels of 18 targeted PFAAs were determined in ca. 100 mother-newborn pairs recruited in France between 2010 and 2013. In serum, the cumulated concentrations of the 7 most frequently detected compounds were 5.70ng/mL and 2.83ng/mL (median values) in maternal and cord serum, respectively. Perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexylesulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) contributed to around 90% of the total PFAAs contamination, with concentration levels and contamination profiles in accordance with other published work in Europe. Levels measured in breast milk were far lower (20 to 150 fold) than those determined in serum. Associations between the different monitored substances as well as between levels determined in the different investigated biological matrices mostly do not appear statistically significant. The estimated materno-foetal transfer would be thus substance-dependant, mainly driven by the physico-chemical properties of the different PFAAs (nature of polar group and length of alkylated side chain). We conclude that trans-placental passage and breastfeeding are both significant routes of human exposure to PFAAs.
authors.affiliation: LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Cariou
authors.affiliation: LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Veyrand
authors.affiliation: LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France; Risk Assessment Department - French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Maisons-Alfort, France.
authors.forename: Ami
authors.initials: A
authors.lastname: Yamada
authors.affiliation: Service de gynécologie-obstétrique, CHU Paule-de-Viguier, 330, avenue de Grande-Bretagne, 31059 Toulouse, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Berrebi
authors.affiliation: INRA, UMR1331, Toxalim, Research Centre in Food Toxicology, Toulouse, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Zalko
authors.affiliation: LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Durand
authors.affiliation: LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Pollono
authors.affiliation: LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Marchand
authors.affiliation: Risk Assessment Department - French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Maisons-Alfort, France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Leblanc
authors.affiliation: LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France; INRA, Nantes F-44307, France. Electronic address: laberca@oniris-nantes.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Antignac
authors.affiliation: LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D017738:Alkanesulfonic Acids / Q000032:analysis* / Q000097:blood; D000818:Animals; D001942:Breast Feeding; D002210:Caprylates / Q000032:analysis* / Q000097:blood; D052244:Endocrine Disruptors / Q000032:analysis* / Q000097:blood; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005466:Fluorocarbons / Q000032:analysis* / Q000097:blood; D005602:France; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D052244:Endocrine Disruptors; D005466:Fluorocarbons; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid
keywords: Biomonitoring; Endocrine disruptors; Perfluoroalkyl substances; Perinatal exposure; Profiling