title: Identifying a novel locus for psoriatic arthritis.
abstract: A number of studies have identified genetic risk loci for PsA, the majority of which also confer risk for psoriasis. The stronger heritability of PsA in comparison with psoriasis suggests that there should be risk loci that are specific for PsA. Identifying such loci could potentially inform therapy development to provide more effective treatments for PsA patients, especially with a considerable proportion being non-responsive to current therapies. Evidence of a PsA-specific locus has been previously found at HLA-B27 within the MHC region. A recent study has provided evidence of non-HLA risk loci that are specific for PsA at IL23R, PTPN22 and on chromosome 5q31. Functional characterization of these loci will provide further understanding of the pathways underlying PsA, and enable us to apply genetic findings for patient benefit.
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences and.
authors.forename: Ashley
authors.initials: A
authors.lastname: Budu-Aggrey
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester.
authors.forename: John
authors.initials: J
authors.lastname: Bowes
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences and The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK anne.barton@manchester.ac.uk.
authors.forename: Anne
authors.initials: A
authors.lastname: Barton
mesh_terms: D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics* / Q000378:metabolism
chemical_list: D015796:HLA-B27 Antigen; D004247:DNA; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22
keywords: Immunochip; Psoriatic arthritis; functional characterization; psoriasis; specific risk loci