title: Male-mediated F1 effects in mice exposed to bisphenol A, either alone or in combination with X-irradiation.
abstract: We investigated the possible transmission of heritable changes via the sperm, following preconceptional exposure of mice to bisphenol A (BPA), either alone or in combination with X-irradiation. Males were exposed for 8 weeks to BPA, X-rays or both agents, and mated to unexposed females. Pre- and postnatal development of the offspring of exposed males was examined. Both BPA alone and the combined exposure slightly affected postnatal development. Combined exposure induced two-fold higher postnatal mortality than BPA the alone, whereas BPA exposure caused reduced body weight and diminished sperm quality in F1 generation.
authors.affiliation: National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland. Electronic address: mdobrzynska@pzh.gov.pl.
authors.forename: Małgorzata M
authors.initials: MM
authors.lastname: Dobrzyńska
authors.affiliation: National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.
authors.forename: Aneta
authors.initials: A
authors.lastname: Gajowik
authors.affiliation: National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Radzikowska
authors.affiliation: National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.
authors.forename: Ewa J
authors.initials: EJ
authors.lastname: Tyrkiel
authors.affiliation: Warsaw Medical University, Warsaw, Poland.
authors.forename: Ewa A
authors.initials: EA
authors.lastname: Jankowska-Steifer
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004968:Estrogens, Non-Steroidal / Q000633:toxicity; D005260:Female; D040582:Inheritance Patterns / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D018812:Paternal Exposure; D010636:Phenols / Q000633:toxicity*; D013094:Spermatozoa / Q000187:drug effects / Q000528:radiation effects; D014965:X-Rays; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Combined exposure; Irradiation; Pre- and postnatal development; Reproduction