title: Antiviral Activity of Four New Resin Glycosides Calysolins XIV-XVII from Calystegia soldanella against Herpes Simplex Virus.
abstract: Four new resin glycosides, named calysolins XIV (1), XV (2), XVI (3), and XVII (4) were isolated from the leaves, stems, and roots of Calystegia soldanella ROEM.. et SCHULT. (Convolvulaceae). Their structures were determined based on spectroscopic and chemical evidence, and consisted of two different types: those (1) with a macrolactone structure and those (2-4) with a non-macrolactone structure. Their sugar moieties were partially acylated by specific organic acids, including tiglic, 2S-methylbutyric, and 2S,3S-nilic acids. Additionally, evaluation of the antiviral activity of 1-4 revealed effects against the herpes simplex virus type 1.
authors.affiliation: School of Agriculture, Tokai University.
authors.forename: Masateru
authors.initials: M
authors.lastname: Ono
authors.forename: Ayako
authors.initials: A
authors.lastname: Takigawa
authors.forename: Haruka
authors.initials: H
authors.lastname: Muto
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kabata
authors.forename: Masafumi
authors.initials: M
authors.lastname: Okawa
authors.forename: Junei
authors.initials: J
authors.lastname: Kinjo
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yokomizo
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshimitsu
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031253:Calystegia / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006561:Herpes Simplex / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans
chemical_list: D000998:Antiviral Agents; D006027:Glycosides