title: Fabrication of rectorite-contained nanoparticles for drug delivery with a green and one-step synthesis method.
abstract: The composite nanoparticles (NPs) consisted of quaternized chitosan (QC)/bovine serum albumin (BSA)/rectorite (REC) were prepared successfully just by adding BSA solution into QC-REC nanocomposites solution via electrostatic interactions. The average diameter of NPs increased with the accretion of REC, which was demonstrated with dynamic laser scattering (DLS) and transmission electron microscopy (TEM). The results of small angle X-ray diffraction (SAXRD) and selected area electron diffraction (SAED) demonstrated that the intercalated structure of REC was enlarged with the addition of REC. Besides, it can was proved that the interaction had occurred between QC and REC in NPs with fourier transform infrared (FT-IR) and X-ray photoelectron spectroscopy (XPS). In addition, doxorubicin (DOX) was used to investigate the entrapment efficiency and release pattern in NPs. It turned out to be that the addition of REC could increase the encapsulation efficiency (EE) and loading capacity (LC). The results also exhibited that the drug release in simulated gastric fluid reduced apparently with the addition of REC, which could ensure more DOX released in intestines.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, Guangxi University, Nanning 530004, China; Department of Environmental Science, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Tu
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, Guangxi University, Nanning 530004, China; Department of Environmental Science, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, Guangxi University, Nanning 530004, China; Department of Environmental Science, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tian
authors.affiliation: Department of Environmental Science, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
authors.forename: Yingfei
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Department of Environmental Science, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Department of Environmental Science, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China. Electronic address: hbdeng@whu.edu.cn.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Deng
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, Guangxi University, Nanning 530004, China. Electronic address: jianglinbin@126.com.
authors.forename: Linbin
authors.initials: L
authors.lastname: Jiang
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005750:Gastric Juice / Q000737:chemistry; D055772:Green Chemistry Technology; D007419:Intestinal Secretions / Q000737:chemistry; D008903:Minerals / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D000538:Aluminum Silicates; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008903:Minerals; C546376:rectorite; D012710:Serum Albumin, Bovine; D004317:Doxorubicin; D048271:Chitosan
keywords: Drug delivery; Green method; Nanoparticles; Rectorite