title: Latency of auditory evoked potential monitoring the effects of general anesthetics on nerve fibers and synapses.
abstract: Auditory evoked potential (AEP) is an effective index for the effects of general anesthetics. However, it's unknown if AEP can differentiate the effects of general anesthetics on nerve fibers and synapses. Presently, we investigated AEP latency and amplitude changes to different acoustic intensities during pentobarbital anesthesia. Latency more regularly changed than amplitude during anesthesia. AEP Latency monotonically decreased with acoustic intensity increase (i.e., latency-intensity curve) and could be fitted to an exponential decay equation, which showed two components, the theoretical minimum latency and stimulus-dependent delay. From the latency-intensity curves, the changes of these two components (∆L and ∆I) were extracted during anesthesia. ∆L and ∆I monitored the effect of pentobarbital on nerve fibers and synapses. Pentobarbital can induce anesthesia, and two side effects, hypoxemia and hypothermia. The hypoxemia was not related with ∆L and ∆I. However, ∆L was changed by the hypothermia, whereas ∆I was changed by the hypothermia and anesthesia. Therefore, we conclude that, AEP latency is superior to amplitude for the effects of general anesthetics, ∆L monitors the effect of hypothermia on nerve fibers, and ∆I monitors a combined effect of anesthesia and hypothermia on synapses. When eliminating the temperature factor, ∆I monitors the anesthesia effect on synapses.
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.|Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Bowan
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Feixue
authors.initials: F
authors.lastname: Liang
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Minlin
authors.initials: M
authors.lastname: Lin
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Linqing
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Jinfan
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Zhongju
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009412:Nerve Fibers; D010424:Pentobarbital / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects*; D013569:Synapses
chemical_list: D018681:Anesthetics, General; D010424:Pentobarbital