title: [Relevant Research on ACE Gene Single Nucleotide Polymorphisms and Premature Coronary Heart Disease Patients with Blood Stasis Syndrome].
abstract: OBJECTIVE
  To explore the relationship between angiotensin converting enzyme (ACE) gene single nucleotide polymorphisms (SNP) and premature coronary heart disease (PCHD) patients with blood stasis syndrome (BSS).
  
  
  METHODS
  rs4343, rs4293, and rs4267385 were selected at SNP from ACE gene. Allele and genotype were detected. Frequencies of allele and genotype were compared by using time-of-flight mass spectrometry technique (TOF-MS).
  
  
  RESULTS
  Compared with the healthy control group, genotype of rs4293 and rs4267385 in ACE gene were similar, but there was statistical difference in polymorphisms and allele frequencies of rs4343 in the I and II group (P < 0.05, P < 0.01). The frequency of G allele was higher in the 3 groups than in the healthy control group (P < 0.05, P < 0.01). The relative risk analysis showed that the risk for PCHD occurrence in G allele carriers at rs4343 (GG +AG) was 3. 6 times the risk in non-G allele carriers (95% CI: 1.224-10.585, P = 0.02). There was also statistical difference in sex, age, TC, and TG after adjusted Logistic regression analysis (OR = 3.994, 95% CI: 1.230-12.974, P = 0.021).
  
  
  CONCLUSIONS
  The polymorphism at rs4343 (G2350A) might be one of risk factors for PCHD occurrence, but not a predisposing factor for PCHD patients of BSS.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Zhi-xi
authors.initials: ZX
authors.lastname: Hu
authors.forename: Wei-xiong
authors.initials: WX
authors.lastname: Jian
authors.forename: Jian-auo
authors.initials: JA
authors.lastname: Wang
authors.forename: Wen-xin
authors.initials: WX
authors.lastname: Yu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Ling
authors.forename: Qian
authors.initials: Q
authors.lastname: Yuan
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008516:Medicine, Chinese Traditional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A