title: The Bounds Of Education In The Human Brain Connectome.
abstract: Inter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite effect on the long-term. These results demonstrate the increased brain efficiency in individuals with higher education level that may mitigate the impact of age on brain functional connectivity.
authors.affiliation: 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal [2] ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal [3] Clinical Academic Center - Braga, Braga, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Marques
authors.affiliation: 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal [2] ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal [3] Clinical Academic Center - Braga, Braga, Portugal.
authors.forename: J M
authors.initials: JM
authors.lastname: Soares
authors.affiliation: 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal [2] ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal [3] Clinical Academic Center - Braga, Braga, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Magalhães
authors.affiliation: 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal [2] ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal [3] Clinical Academic Center - Braga, Braga, Portugal.
authors.forename: N C
authors.initials: NC
authors.lastname: Santos
authors.affiliation: 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal [2] ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal [3] Clinical Academic Center - Braga, Braga, Portugal.
authors.forename: N
authors.initials: N
authors.lastname: Sousa
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D063132:Connectome; D004493:Education; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology*