title: Peptide δ-Turn: Literature Survey and Recent Progress.
abstract: Among the various types of α-peptide folding motifs, δ-turn, which requires a central cis-amide disposition, has been one of the least extensively investigated. In particular, this main-chain reversal topology has been studied in-depth neither in linear/cyclic peptides nor in proteins. This Minireview article assembles and critically analyzes relevant data from a literature survey on the δ-turn conformation in those compounds. Unpublished results from recent conformational energy calculations and a preliminary solution-state analysis on a small model peptide, currently ongoing in our laboratories, are also briefly outlined.
authors.affiliation: ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova (Italy). claudio.toniolo@unipd.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Toniolo
authors.affiliation: ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova (Italy).
authors.forename: Marco
authors.initials: M
authors.lastname: Crisma
authors.affiliation: ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova (Italy).
authors.forename: Alessandro
authors.initials: A
authors.lastname: Moretto
authors.affiliation: ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova (Italy).
authors.forename: Cristina
authors.initials: C
authors.lastname: Peggion
authors.affiliation: ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova (Italy).
authors.forename: Fernando
authors.initials: F
authors.lastname: Formaggio
authors.affiliation: Departament d'Enginyeria Quimica, ETSEIB, Universitat Politècnica de Catalunya, 08028 Barcelona (Spain).
authors.forename: Carlos
authors.initials: C
authors.lastname: Alemán
authors.affiliation: Department of Organic Chemistry, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC - Universidad de Zaragoza, 50009 Zaragoza (Spain).
authors.forename: Carlos
authors.initials: C
authors.lastname: Cativiela
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, 0091 Bangalore (India).
authors.forename: Chandrasekharan
authors.initials: C
authors.lastname: Ramakrishnan
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, 0091 Bangalore (India).
authors.forename: Padmanabhan
authors.initials: P
authors.lastname: Balaram
mesh_terms: D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D011795:Surveys and Questionnaires; D013696:Temperature
chemical_list: D010455:Peptides; D010456:Peptides, Cyclic; D011506:Proteins
keywords: X-ray diffraction; cis-amide; conformational analysis; peptides; statistical analysis