title: Congenital Acute Myeloid Leukemia with Unique Translocation t(11;19)(q23;p13.3).
abstract: Congenital leukemia is rarely encountered in clinical practice, even in tertiary children's hospitals. Leukemia may cause significant coagulopathy, putting the patient at risk of intracranial hemorrhage. In this case, the authors present a female infant with a unique mixed phenotypic congenital acute myeloid leukemia showing mixed-lineage leukemia (MLL) rearrangement and severe coagulopathy resulting in a large subdural hematoma. Despite the fatal outcome in this case, neurosurgical treatment of patients with acute myeloid leukemia should be considered if coagulopathy and the clinical scenario allow.
authors.affiliation: School of Medicine, Washington University School of Medicine.
authors.forename: Chester K
authors.initials: CK
authors.lastname: Yarbrough
authors.affiliation: Neurological Surgery, Washington University School of Medicine.
authors.forename: S Kathleen
authors.initials: SK
authors.lastname: Bandt
authors.affiliation: Pathology, Neuropathology, Keck School of Medicine of USC.
authors.forename: Kyle
authors.initials: K
authors.lastname: Hurth
authors.affiliation: Pediatrics, Newborn Medicine, Washington University School of Medicine.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Wambach
authors.affiliation: Pediatrics, Newborn Medicine, Washington University School of Medicine.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Rao
authors.affiliation: Pathology and Immunology, Washington University School of Medicine.
authors.forename: Shashikant
authors.initials: S
authors.lastname: Kulkarni
authors.affiliation: Pathology and Immunology, Washington University School of Medicine.
authors.forename: Francis V
authors.initials: FV
authors.lastname: White
authors.affiliation: Pathology and Immunology, Washington University School of Medicine.
authors.forename: John L
authors.initials: JL
authors.lastname: Frater
authors.affiliation: Neurological Surgery, The Ohio State University, Nationwide Children's Hospital.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Leonard
keywords: 11q23; 19p13.3; congenital leukemia; fetal leukemia; mll rearrangement; subdural hematoma