title: Magnetic separation-based blood purification: a promising new approach for the removal of disease-causing compounds?
abstract: Recent studies report promising results regarding extracorporeal magnetic separation-based blood purification for the rapid and selective removal of disease-causing compounds from whole blood. High molecular weight compounds, bacteria and cells can be eliminated from blood within minutes, hence offering novel treatment strategies for the management of intoxications and blood stream infections. However, risks associated with incomplete particle separation and the biological consequences of particles entering circulation remain largely unclear. This article discusses the promising future of magnetic separation-based purification while keeping important safety considerations in mind.
authors.affiliation: Institute of Anesthesiology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. ingekherrmann@gmail.com.|Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. ingekherrmann@gmail.com.
authors.forename: I K
authors.initials: IK
authors.lastname: Herrmann
authors.affiliation: Department of Surgery, Swiss HPB and Transplant Center, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. andrea.schlegel@usz.ch.
authors.forename: A A
authors.initials: AA
authors.lastname: Schlegel
authors.affiliation: Department of Surgery, Swiss HPB and Transplant Center, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. rolf.graf@usz.ch.
authors.forename: R
authors.initials: R
authors.lastname: Graf
authors.affiliation: Institute for Chemical and Bioengineering, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland. wendelin.stark@chem.ethz.ch.
authors.forename: W J
authors.initials: WJ
authors.lastname: Stark
authors.affiliation: Institute of Anesthesiology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. beatrice.beckschimmer@uzh.ch.|Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. beatrice.beckschimmer@uzh.ch.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Beck-Schimmer
mesh_terms: D000818:Animals; D058731:Blood Safety / Q000379:methods*; D017848:Blood-Borne Pathogens / Q000302:isolation & purification*; D005112:Extracorporeal Circulation / Q000379:methods*; D006801:Humans; D007378:Interleukins / Q000097:blood / Q000302:isolation & purification; D008280:Magnetics / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000097:blood / Q000302:isolation & purification; D014118:Toxins, Biological / Q000097:blood / Q000302:isolation & purification
chemical_list: D007378:Interleukins; D058185:Magnetite Nanoparticles; D004364:Pharmaceutical Preparations; D014118:Toxins, Biological