title: Association between the Angiogenin (ANG) K17I variant and amyotrophic lateral sclerosis risk in Caucasian: a meta-analysis.
abstract: The study purpose is to perform a meta-analysis to help resolve the debate of whether the Angiogenin (ANG) K17I variant is associated with amyotrophic lateral sclerosis (ALS) risk in Caucasian. Three literature databases were searched for eligible studies published up to January 8, 2015: PubMed, Embase and Web of Science using the following search terms: amyotrophic lateral sclerosis or ALS and Angiogenin or ANG. Five eligible articles were identified, which reported 6 case-control studies and a total of 2326 cases and 3799 controls. The overall results suggested low frequencies of the K17I variant in Caucasian patients (10/2326, 0.43 %) and controls (6/3799, 0.16 %). There is no difference in the variant frequencies between patients with FALS or SALS (p = 0.069). Analysis of pooled odds ratios (ORs) and 95 % confidence intervals (CIs) revealed that the ANG K17I variant increases the risk for ALS (AT vs. AA: OR 2.65, 95 % CI 1.05-6.66, p = 0.038) and familial ALS (FALS) (AT vs. AA: OR 11.81, 95 % CI 2.11-66.15, p = 0.005) but not for sporadic ALS (SALS) (AT vs. AA: OR 1.63, 95 % CI 0.55-4.82, p = 0.378). The ANG K17I variant is rare in Caucasian patients and controls and increases the risk for ALS and FALS but not for SALS in Caucasian populations. Further well-designed studies with larger samples are needed to validate these results.
authors.affiliation: Department of Neurology, The People's Hospital of Yichun City, Yichun University, 88 West Zhong Shan Road, Yichun, 336000, Jiangxi, People's Republic of China.
authors.forename: Lishou
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Neurology, The People's Hospital of Yichun City, Yichun University, 88 West Zhong Shan Road, Yichun, 336000, Jiangxi, People's Republic of China.
authors.forename: Xinbo
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Neurology, The People's Hospital of Yichun City, Yichun University, 88 West Zhong Shan Road, Yichun, 336000, Jiangxi, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Ding
authors.affiliation: Department of Neurology, The People's Hospital of Yichun City, Yichun University, 88 West Zhong Shan Road, Yichun, 336000, Jiangxi, People's Republic of China.
authors.forename: Huilin
authors.initials: H
authors.lastname: Leng
authors.affiliation: Department of Neurology, The People's Hospital of Yichun City, Yichun University, 88 West Zhong Shan Road, Yichun, 336000, Jiangxi, People's Republic of China.
authors.forename: Xuepeng
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Neurology, The People's Hospital of Yichun City, Yichun University, 88 West Zhong Shan Road, Yichun, 336000, Jiangxi, People's Republic of China. neuroyc@163.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012259:Ribonuclease, Pancreatic / Q000235:genetics*; D012306:Risk; D044465:White People
chemical_list: C046366:angiogenin; D012259:Ribonuclease, Pancreatic
keywords: ALS; ANG; Amyotrophic lateral sclerosis; Angiogenin; K17I