title: Quick serological detection of a cancer biomarker with an agglutinated supramolecular glycoprobe.
abstract: While serology represents the forefront technique for cancer diagnosis, current clinical methods for the detection of serum biomarkers have flaws in terms of the need of complicated manipulations, long analytical time, and high cost. Here, we develop a supramolecular glycoprobe for the quick serological detection of a cancer biomarker. The probe formed by agglutination between self-assembled glyco-gold nanoparticles and a lectin shows subtle optical variations upon the competitive recognition of a glycoprotein biomarker secreted by cancer cells, tumor-bearing mice, as well as clinical cancer patients, with no response to a series of controls including the serum of hepatitis patients. This research provides an insight into the development of effective tools for serological diagnosis of cancer.
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: He
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Xi-Le
authors.initials: XL
authors.lastname: Hu
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Jin
authors.affiliation: Huadong Hospital Affiliated to Fudan University , 221 West Yan'an Road, Shanghai 200040, PR China.
authors.forename: Jiemin
authors.initials: J
authors.lastname: Gan
authors.affiliation: Huadong Hospital Affiliated to Fudan University , 221 West Yan'an Road, Shanghai 200040, PR China.
authors.forename: Huili
authors.initials: H
authors.lastname: Zhu
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guo Shoujing Road, Shanghai 201203, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Long
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: He
authors.initials: H
authors.lastname: Tian
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006023:Glycoproteins / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000175:diagnosis; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D015394:Molecular Structure; D010316:Particle Size; D013499:Surface Properties; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D006023:Glycoproteins; D006046:Gold