title: Immunoglobulin E to allergen components of house dust mite in Korean children with allergic disease.
abstract: BACKGROUND
  House dust mites (HDMs) are important sources of indoor allergens. Seventeen components have been identified from Dermatophagoides pteronyssinus (Der p).
  
  
  OBJECTIVE
  Our aim was to define the prevalence of specific IgE to components of Der p in Korea and investigate the clinical features of them in children with allergic disease.
  
  
  METHODS
  We performed a prospective evaluation of 80 HDM sensitized patients with history of allergic rhinitis (AR), atopic dermatitis (AD), asthma and urticaria (UC). Patients underwent ImmunoCAP for total IgE, Der p, Der f, Der p 1, Der p 2, and Der p 10.
  
  
  RESULTS
  Seventy-nine patients had detectable serum IgE to Der p, 80 patients were sensitized to Der f, 66 patients were sensitized to Der p 1, 63 patients to Der p 2, and 7 patients were sensitized to Der p 10. Der p 1 specific IgE was significantly lower in the UC group compared with the AD and AR group. Total IgE was significantly higher in the Der p 10 sensitized group. Der p 10 serum IgE level was highly correlated with crab and shrimp specific IgE. There was a significant positive correlation between total IgE and specific IgE to Der p and its components and Der f.
  
  
  CONCLUSIONS
  Sensitization to HDM and its components in Korea is similar to previous studies from temperate climate. The determination of Der p 1, Der p 2, and Der p 10 specific IgE helps in obtaining additional information in regards to allergic disease.
authors.affiliation: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.
authors.forename: Hwan Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Kang
authors.affiliation: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.
authors.forename: Sulmui
authors.initials: S
authors.lastname: Won
authors.affiliation: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.
authors.forename: Eu Kyoung
authors.initials: EK
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.
authors.forename: Yoon Hong
authors.initials: YH
authors.lastname: Chun
authors.affiliation: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.
authors.forename: Jong-Seo
authors.initials: JS
authors.lastname: Yoon
authors.affiliation: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.
authors.forename: Jin Tack
authors.initials: JT
authors.lastname: Kim
keywords: Child; Dermatophagoides pteronyssinus antigen p 1; Dermatophagoides pteronyssinus antigen p 2; Hypersensitivity, Immediate; Immunoglobulin E; der p 10 protein, Dermatophagoides pteronyssinus