title: Gain-of-function single nucleotide variants of the CYP2C19 gene (CYP2C19*17) can identify subtherapeutic voriconazole concentrations in critically ill patients: a case series.
authors.affiliation: Department of Intensive Care Medicine, Erasmus Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. j.weigel@erasmusmc.nl.
authors.forename: Joachim D
authors.initials: JD
authors.lastname: Weigel
authors.affiliation: Department of Intensive Care Medicine, Erasmus Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.|Department of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Nicole G M
authors.initials: NG
authors.lastname: Hunfeld
authors.affiliation: Department of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Birgit C P
authors.initials: BC
authors.lastname: Koch
authors.affiliation: Department of Intensive Care Medicine, Erasmus Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
authors.forename: Mohamud
authors.initials: M
authors.lastname: Egal
authors.affiliation: Department of Intensive Care Medicine, Erasmus Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Bakker
authors.affiliation: Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Ron H N
authors.initials: RH
authors.lastname: van Schaik
authors.affiliation: Department of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.|Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Teun
authors.initials: T
authors.lastname: van Gelder
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy* / Q000235:genetics; D016638:Critical Illness; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D006801:Humans; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D065819:Voriconazole / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D065819:Voriconazole