title: Bone Ceramic® at Implants Installed Immediately into Extraction Sockets in the Molar Region: An Experimental Study in Dogs.
abstract: OBJECTIVE
  The aim of this paper was to study the healing of 1-1.4 mm wide buccal defects at implants placed immediately into extraction sockets (IPIES) filled with a mixture of synthetic hydroxyapatite (HA) 60% and beta-tricalciumphosphate (TCP) 40% or left with the clot alone and both covered with collagen membranes.
  
  
  METHODS
  Eight Labrador dogs were used and implants were placed immediately into the extraction sockets of the first molar bilaterally. A mixture of synthetic HA 60% and beta-TCP 40% at the test or the clot alone at the control sites were used to fill the defects. All surgical sites were subsequently covered by a resorbable collagen membrane and a non-submerged healing was allowed. After 4 months, the animals were euthanized, biopsies harvested and processed for histomorphometric analysis.
  
  
  RESULTS
  At the time of installation, residual buccal defects occurred that were 1.1 mm and 1.4 mm wide and 3 mm and 4 mm deep at the control and test sites, respectively. After 4 months of healing, the top of the bony crest and the coronal level of osseointegration were located respectively at 0.1 ± 1.8 mm and 1.5 ± 1.8 mm at the test, and 0.6 ± 1.6 mm and 1.2 ± 0.7 mm at the control sites apically to the implant shoulder. Bone-to-implant contact at the buccal aspect was 34.9 ± 25.9% and 36.4 ± 17.3% at the test and control sites, respectively. No statistically significant differences were found between test and control sites for any of the variables analyzed at the buccal aspects.
  
  
  CONCLUSIONS
  The use of a mixture of synthetic HA 60% and beta-TCP 40% to fill residual buccal defects 1-1.4 mm wide at IPIES did not improve significantly the results of healing.
authors.affiliation: Fundação Municipal de Educação e Cultura (FUNEC), Santa Fé do Sul, SP, Brasil.
authors.forename: Flávia Priscila
authors.initials: FP
authors.lastname: Pereira
authors.affiliation: Dental School at Araraquara - UNESP, Araraquara, SP, Brasil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hochuli-Vieira
authors.affiliation: Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: José E
authors.initials: JE
authors.lastname: Maté Sánchez de Val
authors.affiliation: Ariminum Odontologica, ARDEC, Rimini, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: De Santis
authors.affiliation: Department of Oral & Maxillofacial Surgery, The University of São Paulo, Faculty of Dentistry of Ribeirão Preto, Ribeirão Preto, Brazil.
authors.forename: Luiz Antonio
authors.initials: LA
authors.lastname: Salata
authors.affiliation: Ariminum Odontologica, ARDEC, Rimini, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Botticelli
mesh_terms: D000818:Animals; D002516:Ceramics; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D008963:Molar / Q000601:surgery; D016348:Osseointegration; D013524:Surgical Flaps / Q000601:surgery; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*; D014945:Wound Healing
chemical_list: D015921:Dental Implants
keywords: Bone Ceramic®; animal study; beta-TCP; bone ceramic; bone healing; collagen membrane; extraction socket; histology; histomorphometry; implant dentistry; osseointegration; regeneration; ridge preservation; synthetic HA