title: Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property.
abstract: Sodium alginate (SA) and bacterial cellulose (BC) are widely used in many applications such as scaffolds and wound dressings due to its biocompatibility. Silver sulfadiazine (AgSD) is a topical antibacterial agents used as a topical cream on burns. In the study, novel BC/SA-AgSD composites were prepared and characterized by SEM, FTIR and TG analyses. These results indicate AgSD successfully impregnated into BC/SA matrix. The swelling behaviors in different pH were studied and the results showed pH-responsive swelling behaviors. The antibacterial performances of BC/SA-AgSD composites were evaluated with Escherichia coli, Staphylococcus aureus and Candida albicans. Moreover, the cytotoxicity of BC/SA-AgSD composites was performed on HEK 293 cells. The experimental results showed BC/SA-AgSD composites have excellent antibacterial activities and good biocompatibility, thus confirming its utility as potential wound dressings.
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: w.shao@njfu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Shao
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Biotechnology of TCM, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Jimin
authors.initials: J
authors.lastname: Wu
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Huihua
authors.initials: H
authors.lastname: Min
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Huang
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000737:chemistry*; D004339:Drug Compounding; D004926:Escherichia coli / Q000187:drug effects; D020723:Glucuronic Acid / Q000737:chemistry; D057809:HEK293 Cells; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D016062:Porosity; D012837:Silver Sulfadiazine / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013696:Temperature
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D002482:Cellulose; D012837:Silver Sulfadiazine
keywords: Antibacterial activity; Bacterial cellulose; Silver sulfadiazine; Sodium alginate