title: Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome.
abstract: OBJECTIVE
  To investigate the neutrophil-to-lymphocyte ratio and sleep apnoea severity relationship.
  
  
  METHODS
  Patients (n = 178) were assigned to five groups according to apnoea-hypopnea indices and continuous positive airway pressure use. White blood cell, neutrophil, lymphocyte and neutrophil-to-lymphocyte ratio values were compared for each group.
  
  
  RESULTS
  The neutrophil-to-lymphocyte ratio values of severe obstructive sleep apnoea syndrome patients (group 4) were significantly higher than those of: control patients (group 1), mild obstructive sleep apnoea syndrome patients (group 2) and patients treated with continuous positive airway pressure (group 5) (p = 0.008, p = 0.008 and p = 0.003). Minimum oxygen saturation values of group 4 were significantly lower than those of groups 1, 2 and 5 (p = 0.0005, p = 0.011 and p = 0.001). There was a positive correlation between apnoea-hypopnea index and neutrophil-to-lymphocyte ratio (r = 0.758, p = 0.034), and a negative correlation between apnoea-hypopnea index and minimum oxygen saturation (r = -0.179, p = 0.012).
  
  
  CONCLUSIONS
  Neutrophil-to-lymphocyte ratio may be used to determine disease severity, complementing polysomnography.
authors.affiliation: Department of Otorhinolaryngology,Faculty of Medicine,Bezmialem Vakif University,Istanbul,Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yenigun
authors.affiliation: Department of Respiratory Medicine,Faculty of Medicine,Mevlana University,Konya,Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Karamanli
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000276:immunology*; D013223:Statistics as Topic
chemical_list: D010100:Oxygen
keywords: Lymphocytes; Neutrophils; Obstructive Sleep Apnea Syndrome; Sleep Apnea; Upper Airway Resistance Sleep Apnea Syndrome