title: Easy Access to Supramolecular Gels of the Nonsteroidal Anti-inflammatory Drug Diflunisal: Synthesis, Characterization, and Plausible Biomedical Applications.
abstract: By exploiting salt formation, a new series of primary ammonium monocarboxylate salts of a nonsteroidal anti-inflammatory drug, namely, diflunisal, was synthesized. The majority of the salts thus synthesized turned out to be good gelators of various solvents, including the solvents (e.g., methyl salicylate and pure water) typically used for topical gel formulation. Single-crystal X-ray diffraction studies of a few gelator and nongelator salts in the series revealed details of the hydrogen-bonding networks present in the salts. Furthermore, one such gelator salt, namely, the diflunisal salt of serinol, was found to be biocompatible (MTT assay), and its anti-inflammatory (PGE2 assay) response turned out to be as good as that of the parent drug, which is indicative of its potential in biomedical applications.
authors.affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science, 2A & 2B Raja S.C. Mullick Road, Kolkata-, 700032, West Bengal, India.
authors.forename: Rumana
authors.initials: R
authors.lastname: Parveen
authors.affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science, 2A & 2B Raja S.C. Mullick Road, Kolkata-, 700032, West Bengal, India. ocpd@iacs.res.in.
authors.forename: Parthasarathi
authors.initials: P
authors.lastname: Dastidar
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004061:Diflunisal / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism; D015195:Drug Design; D005782:Gels / Q000737:chemistry; D006860:Hydrogen Bonding; D051379:Mice; D008968:Molecular Conformation; D000067996:RAW 264.7 Cells; D012492:Salts / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D012492:Salts; D004061:Diflunisal; D015232:Dinoprostone
keywords: anti-inflammatory agents; drug design; gels; safins; supramolecular chemistry