title: PCC characteristics at rest in 10-year memory decliners.
abstract: The present research sought to characterize the intrinsic functional networks associated with a 10-year episodic memory decline in elderly using data from a longitudinal population-based cohort (Bordeaux-3City). Complementary measures of whole-brain resting-state functional magnetic resonance imaging investigations were combined to compare functional architecture of brain networks both at connectional and topological levels in 22 decliners to 22 nondecliners; episodic memory decline being assessed through a multiple time point Free and Cued Selective Reminding Test. The decliners presented differences in functional architecture centered on the posterior cingulate cortex, characterized by a significant decrease of connectivity intensity, a significant increased centrality. In accordance, a decrease of the functional connectivity inside the default mode network was observed in the decliners. Our results highlight the central role of the posterior cingulate cortex in a slow but reliable memory decline in elderly. Because functional alterations of this region are currently described in Alzheimer's disease, this functional signature could constitute a risk for Alzheimer's disease.
authors.affiliation: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, Talence, France; Centre National de la Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France; Ecole Pratique des Hautes Etudes (EPHE), Bordeaux, France. Electronic address: charlotte.bernard1@yahoo.fr.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Bernard
authors.affiliation: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, Talence, France; Centre National de la Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France.
authors.forename: Bixente
authors.initials: B
authors.lastname: Dilharreguy
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France; INSERM, Clinical Investigation Center-Clinical Epidemiology 7, Bordeaux, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Helmer
authors.affiliation: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, Talence, France; Centre National de la Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France; Ecole Pratique des Hautes Etudes (EPHE), Bordeaux, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Chanraud
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France; Memory Consultation, University Hospital, Centre Mémoire de Ressources et de Recherche (CMRR), Bordeaux, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.affiliation: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, Talence, France; Centre National de la Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France; Ecole Pratique des Hautes Etudes (EPHE), Bordeaux, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Allard
authors.affiliation: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, Talence, France; Centre National de la Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France; Ecole Pratique des Hautes Etudes (EPHE), Bordeaux, France.
authors.forename: Gwénaëlle
authors.initials: G
authors.lastname: Catheline
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000523:psychology*; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D059906:Neuroimaging; D012146:Rest / Q000502:physiology*; D013997:Time Factors
keywords: Aging; Graph theory; Memory decline; NBS; PCC; Resting-state fMRI