title: Stem Cells: Potential Therapy for Neonatal Injury?
abstract: Stem cell transplantation (SCT) is an established first-line or adjunctive therapy for a variety of neonatal and adult diseases. New evidence in preclinical models as well as a few human studies show the potential utility of SCT in neuroprotection and in the modulation of inflammatory injury in at risk-neonates. This review briefly summarizes current understanding of human stem cell biology during ontogeny and present recent evidence supporting SCT as a viable approach for postinsult neonatal injury.
authors.affiliation: Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, R4-W116, Indianapolis, IN 46202, USA.
authors.forename: Momoko
authors.initials: M
authors.lastname: Yoshimoto
authors.affiliation: Pediatrics, E Doisy Research Center, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St Louis, MO 63104, USA; Molecular Microbiology & Immunology, E Doisy Research Center, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St Louis, MO 63106, USA. Electronic address: koenijm@slu.edu.
authors.forename: Joyce M
authors.initials: JM
authors.lastname: Koenig
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D000066829:Neuroprotection; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*
keywords: Cord blood; Hematopoiesis; Injury; Neonate; Stem cells; Transplantation