title: Effects of osmoprotective eye drops on tear osmolarity in contact lens wearers.
abstract: OBJECTIVE
  To evaluate the impact of osmoprotective eye drops on tear osmolarity and patient comfort, and to compare its efficacy with a commercially available lubricant in contact lens (CL) wearers.
  
  
  METHODS
  Prospective, cross-sectional study.
  
  
  METHODS
  Forty eyes of 20 first-time CL wearers were included.
  
  
  METHODS
  Tear osmolarity measurements using TearLab osmolarity system were performed in each eye of subjects at 8 am, and 2, 4, and 8 h after that on the first and second days, and at 12:00 on the third day and eighth days. On the second day and afterward, all eyes were fitted Purevision 2 (Bausch & Lomb) soft CLs. Subjects instilled Optive (Allergan) osmoprotective eye drops into their 1 eye (group 1) and Refresh tears (Allergan) eye drops into their other eyes (group 2) after 2 hours of CL wear on the third day and afterward. Ocular comfort with eye drops was also assessed.
  
  
  RESULTS
  There were no significant differences between the tear osmolarity measurements of the groups on the first day. On the second day, osmolarity significantly increased from baseline after 4 h of CL wear (p < 0.05) but returned to baseline after 8 h of CL wear (p > 0.05) in both groups. Tear osmolarity measurements of group 1 were significantly lower than those of group 2 on the third and eighth days (both p < 0.05). The mean comfort scores were significantly higher in group 1.
  
  
  CONCLUSIONS
  Tear osmolarity increases within the first hours of CL wear, and instillation of osmoprotective eye drops prevents this increment in patients wearing CLs.
authors.affiliation: Bozok University Faculty of Medicine, Ophthalmology Department, Yozgat, Turkey. Electronic address: seraybayhan@hotmail.com.
authors.forename: Seray
authors.initials: S
authors.lastname: Aslan Bayhan
authors.affiliation: Bozok University Faculty of Medicine, Ophthalmology Department, Yozgat, Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Bayhan
authors.affiliation: Bozok University Faculty of Medicine, Ophthalmology Department, Yozgat, Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Muhafız
authors.affiliation: Bozok University Faculty of Medicine, Ophthalmology Department, Yozgat, Turkey.
authors.forename: Şükran
authors.initials: Ş
authors.lastname: Bekdemir
authors.affiliation: Bozok University Faculty of Medicine, Ophthalmology Department, Yozgat, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Gürdal
mesh_terms: D000328:Adult; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D015352:Dry Eye Syndromes / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D065346:Lubricant Eye Drops / Q000008:administration & dosage*; D054327:Lubricants; D008297:Male; D009994:Osmolar Concentration; D017060:Patient Satisfaction; D011446:Prospective Studies; D012030:Refractive Errors / Q000628:therapy; D011795:Surveys and Questionnaires; D013666:Tears / Q000737:chemistry*
chemical_list: D065346:Lubricant Eye Drops; D054327:Lubricants