title: Early detection with the β-LACTA™ test of extended-spectrum β-lactamase-producing Enterobacteriaceae in blood cultures.
abstract: Effective antibiotic therapy is crucial for the outcome of septic patients and requires early diagnosis of β-lactam resistance in cases of Gram-negative bacteremia. Here, we report high sensitivity of the β-LACTA™ test in rapid detection of extended-spectrum β-lactamase-producing Enterobacteriaceae in blood cultures positive for Gram-negative bacilli.
authors.affiliation: Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France. Electronic address: violaine.walewski@aphp.fr.
authors.forename: V
authors.initials: V
authors.lastname: Walewski
authors.affiliation: Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France; Université Paris Descartes, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Podglajen
authors.affiliation: Microbiology, AP-HP, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Lefeuvre
authors.affiliation: Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Dutasta
authors.affiliation: Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Neuschwander
authors.affiliation: Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Tilouche
authors.affiliation: Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France; Université Paris Descartes, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Carbonnelle
authors.affiliation: Université Paris Descartes, Paris, France; Microbiology, AP-HP, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Ferroni
mesh_terms: D016470:Bacteremia / Q000175:diagnosis*; D001769:Blood / Q000382:microbiology*; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis*; D006801:Humans; D012680:Sensitivity and Specificity; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases
keywords: Beta-lactamin; ESBL; Enterobacteriaceae; antibiotic resistance; rapid diagnostic test