title: Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12.
abstract: Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest. The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C. militaris SU-12, and to investigate the pharmacological effects of RPS on lipid metabolism and oxidative stress. RPS was composed of glucose, arabinose and mannose with a ratio of 62:1.6:1 by gas chromatography analysis, and the Mw (weight-average molecular weight), Mn (number-average molecular weight) and Mz (z-average molecular weight) of RPS were 2.86×10(3), 6.85×10(2), and 1.97×10(4)Da, respectively. The mice experiments demonstrated that RPS could reduce the levels of blood and liver lipid, and improve the glutamate pyruvate transaminase and antioxidant activity. The histopathological observations of mice livers indicated that RPS could attenuate liver cell injury. Results suggest that the RPS might be used as a potential antihyperlipidemic, hepatoprotective and antioxidant product.
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors.forename: Nuo
authors.initials: N
authors.lastname: Xu
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Zhao
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.affiliation: College of Chemistry and Material Science, Shandong Agricultural University, Taian, Shandong 271018, PR China. Electronic address: shjia@sdau.edu.cn.
authors.forename: Shouhua
authors.initials: S
authors.lastname: Jia
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China. Electronic address: jiale0525@163.com.
authors.forename: Le
authors.initials: L
authors.lastname: Jia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002849:Chromatography, Gas; D032661:Cordyceps / Q000737:chemistry*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008970:Molecular Weight; D011134:Polysaccharides / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D012015:Reference Standards; D017550:Spectroscopy, Fourier Transform Infrared; D013482:Superoxide Dismutase / Q000097:blood; D000637:Transaminases / Q000378:metabolism
chemical_list: D000975:Antioxidants; D000960:Hypolipidemic Agents; D008055:Lipids; D011134:Polysaccharides; D020011:Protective Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000637:Transaminases
keywords: Antihyperlipidemic activity; Antioxidant activity; Cordyceps militaris SU-12; Hepatoprotective effect; Residue polysaccharide