title: Recurrence of Focal and Segmental Glomerulosclerosis After Transplantation.
abstract: Focal segmental glomerulosclerosis, which is a common glomerular disorder, manifests clinically with a nephrotic syndrome and has a high propensity for recurrence after kidney transplantation. The pathophysiology is currently unknown, and podocytes appear to be the target of one or several circulating factor(s) that lead to the recurrence of proteinuria after kidney transplantation. Identifying these circulating factor(s) and cells involved in its synthesis remains elusive; however, recently, our research on podocyte cytoskeleton biology has opened a new era of treatment. This review will highlight recent progress in the physiopathology of focal segmental glomerulosclerosis recurrence after transplantation and its treatment.
authors.affiliation: 1 Université Paris Descartes, Rue de l'Ecole de Médecine, Paris, France. 2 Service de Néphrologie et Transplantation, Hôpital Necker, Paris, France. 3 Institut National de la Recherche U1151, Hôpital Necker, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Canaud
authors.forename: Marianne
authors.initials: M
authors.lastname: Delville
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
mesh_terms: D000818:Animals; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D012008:Recurrence; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome