title: Hepatitis B Virus Infection, MicroRNAs and Liver Disease.
abstract: Hepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across the world. Recently,microRNAs (miRNAs) have emerged as important modulators of gene function. Studies on the role of miRNA in the regulation of hepatitis B virus gene expression have been the focus of modern antiviral research. miRNAs can regulate viral replication and pathogenesis in a number of different ways, which includefacilitation, direct or indirect inhibition, activation of immune response, epigenetic modulation, etc. Nevertheless, these mechanisms can appropriately be used with a diagnosticand/or therapeutic approach. The present review is an attempt to classify specific miRNAs that are reported to be associated with various aspects of hepatitis B biology, in order to precisely present the participation of individual miRNAs in multiple aspects relating to HBV.
authors.affiliation: ICMR Virus Unit, Kolkata, ID & BG Hospital Campus, Kolkata-700010, India. neelakshisarkar@gmail.com.
authors.forename: Neelakshi
authors.initials: N
authors.lastname: Sarkar
authors.affiliation: ICMR Virus Unit, Kolkata, ID & BG Hospital Campus, Kolkata-700010, India. runugc@gmail.com.
authors.forename: Runu
authors.initials: R
authors.lastname: Chakravarty
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000821:virology; D006509:Hepatitis B / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000821:virology; D008113:Liver Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000821:virology; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: HBV; chronic; hepatocellular carcinoma; liver cirrhosis; miRNA