title: Nanostructures for the Inhibition of Viral Infections.
abstract: Multivalent interactions are omnipresent in biology and confer biological systems with dramatically enhanced affinities towards different receptors. Such multivalent binding interactions have lately been considered for the development of new therapeutic strategies against bacterial and viral infections. Multivalent polymers, dendrimers, and liposomes have successfully targeted pathogenic interactions. While a high synthetic effort was often needed for the development of such therapeutics, the integration of multiple ligands onto nanostructures turned to be a viable alternative. Particles modified with multiple ligands have the additional advantage of creating a high local concentration of binding molecules. This review article will summarize the different nanoparticle-based approaches currently available for the treatment of viral infections.
authors.affiliation: Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR 8520 CNRS, Lille1 University, Avenue Poincaré-BP 60069, 59652 Villeneuve d\'Ascq, France. sabine.szunerits@iri.univ-lille1.fr.
authors.forename: Sabine
authors.initials: S
authors.lastname: Szunerits
authors.affiliation: Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR 8520 CNRS, Lille1 University, Avenue Poincaré-BP 60069, 59652 Villeneuve d\'Ascq, France. alexandre.barras@iri.univ-lille1.fr.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Barras
authors.affiliation: Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR 8520 CNRS, Lille1 University, Avenue Poincaré-BP 60069, 59652 Villeneuve d\'Ascq, France. manukhl@hotmail.com.
authors.forename: Manakamana
authors.initials: M
authors.lastname: Khanal
authors.affiliation: Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR 8520 CNRS, Lille1 University, Avenue Poincaré-BP 60069, 59652 Villeneuve d\'Ascq, France. quentin.pagneux@etudiant.univ-lille1.fr.
authors.forename: Quentin
authors.initials: Q
authors.lastname: Pagneux
authors.affiliation: Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR 8520 CNRS, Lille1 University, Avenue Poincaré-BP 60069, 59652 Villeneuve d\'Ascq, France. rabah.boukherroub@univ-lille1.fr.
authors.forename: Rabah
authors.initials: R
authors.lastname: Boukherroub
mesh_terms: D004337:Drug Carriers; D008954:Models, Biological; D049329:Nanostructures / Q000627:therapeutic use*; D014759:Viral Envelope Proteins / Q000737:chemistry; D014777:Virus Diseases / Q000188:drug therapy*; D014779:Virus Replication
chemical_list: D004337:Drug Carriers; D014759:Viral Envelope Proteins
keywords: antiviral therapy; nanomaterials; viral infections