title: Synthesis of dual-functional targeting probes for cancer theranostics based on iron oxide nanoparticles coated by centipede-like polymer connected with pH-responsive anticancer drug.
abstract: A tumor-targeted and pH-responsive drug release system based on superparamagnetic iron oxide nanoparticles (IONPs) coated by poly(ethylene glycol) (PEG) and dodecylamine (DDA)-modified polyitaconic acid (PIA) connecting with bortezomib (BTZ) (PIA-PEG-DDA-BTZ@IOs) has been constructed and characterized. The anticancer drug BTZ was first conjugated using dopamine as the linker via catechol borate ester bond, which is acid cleavable and used as an ideal pH-responsive drug release system. The IONPs were then coated by PIA-PEG-DDA-BTZ to form micelles with good biocompatibility. The conjugates were further designed to target liver cancer cells overexpressing vascular endothelial growth factor (VEGF) by the targeting molecule anti-vascular endothelial growth factor (anti-VEGF). The magnetic resonance imaging showed that the targeting capability of IONPs-anti-VEGF conjugates to Hep G2 cells was more significant than that of non-anti-VEGF IONPs. From the above, this kind of novel dual-functional targeting probe could provide a new idea for the diagnosis and treatment of cancer.
authors.affiliation: a Alan G. MacDiarmid Laboratory , Jilin University , Changchun 130012 , China.
authors.forename: Haochen
authors.initials: H
authors.lastname: Zhao
authors.affiliation: b College of Basic Medical Sciences , Jilin University , Changchun 130012 , China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Li
authors.affiliation: c The 42nd Institute, The Fourth Academy of China Aerospace Science and Technology Corporation , Xiangyang 441003 , China.
authors.forename: Bohan
authors.initials: B
authors.lastname: Yang
authors.affiliation: a Alan G. MacDiarmid Laboratory , Jilin University , Changchun 130012 , China.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Alan G. MacDiarmid Laboratory , Jilin University , Changchun 130012 , China.
authors.forename: Yapeng
authors.initials: Y
authors.lastname: Li
mesh_terms: D065567:Absorption, Physiological; D000588:Amines / Q000737:chemistry; D000818:Animals; D055910:Antibodies, Immobilized / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D000069286:Bortezomib / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems; D065546:Drug Liberation; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008297:Male; D008813:Mice, Inbred ICR; D011092:Polyethylene Glycols / Q000737:chemistry; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D013386:Succinates / Q000737:chemistry; D013499:Surface Properties; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014018:Tissue Distribution; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D000588:Amines; D055910:Antibodies, Immobilized; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D011994:Recombinant Proteins; D013386:Succinates; D042461:Vascular Endothelial Growth Factor A; D011092:Polyethylene Glycols; D000069286:Bortezomib; C005229:itaconic acid; C003935:dodecylamine
keywords: bortezomib; cancer treatment; magnetic resonance imaging; pH-responsive; targeting imaging