title: Breakdown of the striatal-default mode network loop in schizophrenia.
abstract: The striatum has been shown to be a core region in schizophrenia with functional and structural deficits. Previous studies have confirmed the schizophrenia-related functional connectivity between the striatal and cortical regions. However, among these, few studies have attempted to determine the directional flow of the influence. In the present study, we used resting-state fMRI to explore the directed connectivity between the striatum and the cortical regions in schizophrenia. Employing a Granger causality analysis, we observed a significant failure of the directed inhibitory influence of the striatum on the default mode network (DMN) in schizophrenia. Furthermore, the reciprocal influence of the DMN on the striatum was also significantly reduced. These findings provide compelling evidence for a breakdown of the striatum-DMN loop in schizophrenia. This abnormal connectivity could be related to clinical variables. In conclusion, our study suggests that abnormally directed influences between the striatum and the DMN might be a biomarker of schizophrenia and also reveals a potential target for treatment.
authors.affiliation: Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Xiangpeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Li
authors.affiliation: 2nd People's Hospital of Beibei, Chongqing 400712, China.
authors.forename: Hanfeng
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.affiliation: Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: 2nd People's Hospital of Beibei, Chongqing 400712, China.
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Institute of Psychology, Chinese Academy of Science, Beijing 100101, China.
authors.forename: Raymond C K
authors.initials: RC
authors.lastname: Chan
authors.affiliation: Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China. Electronic address: xscat@swu.edu.cn.
authors.forename: Antao
authors.initials: A
authors.lastname: Chen
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003342:Corpus Striatum / Q000098:blood supply / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000098:blood supply / Q000473:pathology*; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Amplitude of low frequency fluctuation; Default mode network; Effective connectivity; Granger causality analysis; Schizophrenia; Striatum