title: Association Between Hypertension, Menopause, and Cognition in Women.
abstract: The aim of this study was to investigate the cognitive state in women and its relation to menopause and hypertension (HTN). The authors included 1034 women aged 47.13±15.71 years. The prevalence of HTN was 47.1%, with 67.8% of patients treated and 48.6% controlled. Cognitive impairment was higher among hypertensive menopausal (mini-Boston Naming Test: 7.4±3.1 vs 8.5±2.4, P<.001; Clock-Drawing Test: 5.2±2 vs 5.6±1.6, P<.01). Using logistic regression adjusted by age and education level, statistical differences were found in the results from the mini-Boston Naming Test between menopausal hypertensive vs menopausal normotensive women (odds ratio, 1.48; 95% confidence interval, 1.06-2.07; P=.021), and no difference between nonmenopausal hypertensive vs menopausal normotensive women (odds ratio, 0.89; 95% confidence interval, 0.51-1.57; P=.697). The P interaction between both groups was significant (P=.038). The possibility of alteration in cortical functions in menopausal hypertensive woman showed a relative increment of 48% (P=.021). The association between HTN and menopause increases the possibility of compromising the semantic memory by 50%.
authors.affiliation: Physiology Course at the School of Pharmacy and Biochemistry, University of Buenos Aires, IQUIMEFA-CONICET, CABA, Argentina.|Departamento de Prevención Cardiovascular, Unidad de Hipertensión, Instituto Cardiovascular de Buenos Aires (ICBA), CABA, Argentina.|Servicio de Cardiología, Unidad Hipertensión Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Zilberman
authors.affiliation: Departamento de Cardiología, Hospital Aeronáutico Central, Buenos Aires, Argentina.|Departamento de Cardiología, Unidad Corazón y Cerebro, Instituto Cardiovascular de Buenos Aires (ICBA), CABA, Argentina.
authors.forename: Gustavo H
authors.initials: GH
authors.lastname: Cerezo
authors.affiliation: Programa Corazón Sano, Municipalidad de Villa Maria, Cordoba.|División Cardiología y Prevención Cardiovascular, Clínica de Especialidades, Villa María, Córdoba, Argentina.
authors.forename: Mildren
authors.initials: M
authors.lastname: Del Sueldo
authors.affiliation: Unidad de Metodología y Epidemiología Clínica, Servicio de Medicina Preventiva, Instituto de Investigación Sanitaria, Hospital Clínico San Carlos, UCM, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Fernandez-Pérez
authors.affiliation: Unidad de Hipertensión, Servicio de Medicina Interna, Instituto de Investigación Sanitaria, Hospital Clínico San Carlos, UCM, Madrid, Spain.
authors.forename: Nieves
authors.initials: N
authors.lastname: Martell-Claros
authors.affiliation: Departamento de Cardiología, Unidad Corazón y Cerebro, Instituto Cardiovascular de Buenos Aires (ICBA), CABA, Argentina.
authors.forename: Augusto
authors.initials: A
authors.lastname: Vicario
mesh_terms: D000328:Adult; D001118:Argentina / Q000453:epidemiology; D001794:Blood Pressure / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology; D008569:Memory Disorders / Q000453:epidemiology; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D015995:Prevalence