title: T-lymphocyte subset dynamics in well-treated HIV-infected men during a bout of exhausting exercise.
abstract: In healthy individuals the substantial lymphocytosis during a bout of exhausting exercise constitutes primarily mature T cells from the peripheral lymphoid organs but naïve T cells are also recruited. This study investigated whether the defective CD4 + T-lymphocyte count in peripheral blood during rest in human immunodeficiency virus (HIV)-infected patients would also be observed following a maximal output ergometer bicycle test. At rest, in 45 well-treated HIV-infected patients, mature and naïve CD4 + T-lymphocyte counts were decreased whereas the less immune active CD8 + T lymphocytes were increased compared with 10 healthy control subjects. In response to exercise mature and naïve CD4 + T lymphocytes increased less and mature and naïve CD8 + T lymphocytes increased most in HIV-infected patients. In conclusion, defective resting mature and naïve CD4 + T lymphocytes in well-treated HIV-infected patients are also reflected in defective acutely mobilized active immune cells following exhausting exercise. The CD4 + T-lymphocyte count is highly sensitive to physical activity.
authors.affiliation: a From the Clinical Research Centre, University of Copenhagen , Hvidovre , Denmark.|c Department of Infectious Diseases , Amager Hvidovre Hospital, University of Copenhagen , Hvidovre , Denmark.
authors.forename: Carsten
authors.initials: C
authors.lastname: Dirksen
authors.affiliation: a From the Clinical Research Centre, University of Copenhagen , Hvidovre , Denmark.|c Department of Infectious Diseases , Amager Hvidovre Hospital, University of Copenhagen , Hvidovre , Denmark.
authors.forename: Birgitte R
authors.initials: BR
authors.lastname: Hansen
authors.affiliation: a From the Clinical Research Centre, University of Copenhagen , Hvidovre , Denmark.|c Department of Infectious Diseases , Amager Hvidovre Hospital, University of Copenhagen , Hvidovre , Denmark.
authors.forename: Lilian
authors.initials: L
authors.lastname: Kolte
authors.affiliation: a From the Clinical Research Centre, University of Copenhagen , Hvidovre , Denmark.|b Department of Endocrinology , University of Copenhagen , Hvidovre , Denmark.
authors.forename: Steen B
authors.initials: SB
authors.lastname: Haugaard
authors.affiliation: a From the Clinical Research Centre, University of Copenhagen , Hvidovre , Denmark.|c Department of Infectious Diseases , Amager Hvidovre Hospital, University of Copenhagen , Hvidovre , Denmark.
authors.forename: Ove
authors.initials: O
authors.lastname: Andersen
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D015444:Exercise; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D019562:Viral Load / Q000276:immunology; D055815:Young Adult
keywords: CD4 + cell counts; CD8 + cell counts; HIV; acute exercise; immunology