title: miRegulome: a knowledge-base of miRNA regulomics and analysis.
abstract: miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide information on specific aspects of miRNA regulation. However, an integrated resource on the miRNA regulome is currently not available to facilitate the exploration and understanding of miRNA regulomics. miRegulome attempts to bridge this gap. The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature. Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding. Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics. With added features in upcoming releases, miRegulome will be an essential resource to the scientific community.
  
  
  BACKGROUND
  http://bnet.egr.vcu.edu/miRegulome.
authors.affiliation: Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India.
authors.forename: Debmalya
authors.initials: D
authors.lastname: Barh
authors.affiliation: Department of Computer Science, Virginia Commonwealth University, Richmond, VA-23284, USA.
authors.forename: Bhanu
authors.initials: B
authors.lastname: Kamapantula
authors.affiliation: 1] Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India [2] School of Biotechnology, Devi Ahilya University, Khandwa Road Campus, Indore, MP, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Jain
authors.affiliation: Department of Computer Science, Virginia Commonwealth University, Richmond, VA-23284, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Nalluri
authors.affiliation: Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India.
authors.forename: Antaripa
authors.initials: A
authors.lastname: Bhattacharya
authors.affiliation: 1] Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India [2] School of Biotechnology, Devi Ahilya University, Khandwa Road Campus, Indore, MP, India.
authors.forename: Lucky
authors.initials: L
authors.lastname: Juneja
authors.affiliation: 1] Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India [2] School of Biotechnology, Devi Ahilya University, Khandwa Road Campus, Indore, MP, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Barve
authors.affiliation: 1] Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India [2] Laboratorio de Genetica Celular eMolecular, Departmento de Biologia Geral, Instituto de Ciencias Biologics, Universidade Federal de Minas Gerais CP 486, CEP 31270-901 Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Tiwari
authors.affiliation: Laboratorio de Genetica Celular eMolecular, Departmento de Biologia Geral, Instituto de Ciencias Biologics, Universidade Federal de Minas Gerais CP 486, CEP 31270-901 Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Anderson
authors.initials: A
authors.lastname: Miyoshi
authors.affiliation: Laboratorio de Genetica Celular eMolecular, Departmento de Biologia Geral, Instituto de Ciencias Biologics, Universidade Federal de Minas Gerais CP 486, CEP 31270-901 Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Vasco
authors.initials: V
authors.lastname: Azevedo
authors.affiliation: 1] Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India [2] Department of Psychiatry and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, Florida, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Blum
authors.affiliation: School of Biotechnology, Devi Ahilya University, Khandwa Road Campus, Indore, MP, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Instituto de Ciências Biológicas, Universidade Federal do Pará, Rua Augusto Corrêa, 01 - Guamá, Belém, PA, Brazil.
authors.forename: Artur
authors.initials: A
authors.lastname: Silva
authors.affiliation: Department of Computer Science, Virginia Commonwealth University, Richmond, VA-23284, USA.
authors.forename: Preetam
authors.initials: P
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D053263:Gene Regulatory Networks; D006801:Humans; D051188:Knowledge Bases; D035683:MicroRNAs / Q000235:genetics*; D034622:RNA Interference; D012984:Software
chemical_list: D035683:MicroRNAs