title: Cationic amphiphilic microfibrillated cellulose (MFC) for potential use for bile acid sorption.
abstract: In this work, Micro-fibrillated Cellulose (MFC) was cationically modified by quaternary ammonium groups with different chemical structures aiming to improve the sorption capacity to bile acid. The in-vitro bile acid sorption was performed by investigating various factors, such as quaternary ammonium group content and length of its alkyl substituent of the modified cationic MFC (CMFC), ionic strength, initial concentration and hydrophobicity of bile acid. The results showed that the sorption behavior of the modified CMFC was strongly influenced by the quaternary ammonium group content and the lengths of its alkyl substituent, the sorption capacity for the modified CMFC with a C18 alkyl substituent, was approximately 50% of that of Cholestyramine. The experimental isotherm results were well fitted into the Temkin model. The effect of salts in the solution was smaller for the bile acid sorption onto the hydrophobic CMFC than the CMFC. It was also found that the binding capacity of CMFC was higher for more hydrophobic deoxycholate in comparison with cholate.
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China.
authors.forename: Xuhai
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China; Limerick Pulp & Paper Centre & Department of Chemical Engineering, University of New Brunswick, Fredericton, NB, Canada E3B 5A3. Electronic address: yangbingwen@tust.edu.cn.
authors.forename: Yangbing
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Changmo
authors.initials: C
authors.lastname: Li
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China.
authors.forename: Xingye
authors.initials: X
authors.lastname: An
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China; Limerick Pulp & Paper Centre & Department of Chemical Engineering, University of New Brunswick, Fredericton, NB, Canada E3B 5A3.
authors.forename: Yonghao
authors.initials: Y
authors.lastname: Ni
mesh_terms: D000327:Adsorption; D001647:Bile Acids and Salts / Q000737:chemistry*; D002412:Cations / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001647:Bile Acids and Salts; D002412:Cations; D002482:Cellulose
keywords: Bile acid; Cationization; Hydrophobization; Microfibrillated cellulose; Sorption