title: Beta-cell-tropin is associated with short-term stimulation of food intake in chicks.
abstract: Beta-cell-tropin, a peptide derived from adrenocorticotropic hormone, is an insulin secretagogue. When centrally injected, it increases food intake in rats, but its appetite-associated effects have not been reported in any other species. Thus, the present study was designed to evaluate the effects of central beta-cell-tropin on appetite-associated parameters in an alternative vertebrate model, the chick. Central injection of 2 or 4 nmol beta-cell-tropin increased food intake for 60 min. Whole hypothalamus was collected at 60 min post-injection, and real-time PCR performed to measure mRNA abundance of agouti-related peptide, corticotropin releasing factor, galanin, melanin concentrating hormone, neuropeptide Y, orexin, prohormone convertase 2, pro-opiomelanocortin, peroxisome proliferator-activated receptor γ, urotensin 2, and visfatin, not one of which were affected by beta-cell-tropin treatment. Results demonstrate that beta-cell-tropin is associated with short-term stimulation of food intake.
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Shipp
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
authors.forename: Marissa L
authors.initials: ML
authors.lastname: Smith
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Gilbert
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. Electronic address: macline2@vt.edu.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Cline
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D002645:Chickens / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000235:genetics; D004435:Eating / Q000187:drug effects* / Q000502:physiology*; D006728:Hormones / Q000494:pharmacology; D007028:Hypothalamic Hormones / Q000235:genetics; D007031:Hypothalamus / Q000378:metabolism*; D008543:Melanins / Q000235:genetics; D009478:Neuropeptide Y / Q000235:genetics; D047495:PPAR gamma / Q000235:genetics; D010446:Peptide Fragments / Q000494:pharmacology*; D010907:Pituitary Hormones / Q000235:genetics; D011333:Pro-Opiomelanocortin / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D006728:Hormones; D007028:Hypothalamic Hormones; D008543:Melanins; D009478:Neuropeptide Y; D047495:PPAR gamma; D010446:Peptide Fragments; D010907:Pituitary Hormones; D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin; C019463:melanin-concentrating hormone; C026834:beta-cell tropin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone
keywords: Beta-cell-tropin; Chick; Food intake; Hypothalamus