title: Hepatocellular Carcinoma in a Patient with Polycystic Liver Disease.
abstract: A 49-year-old Japanese woman with polycystic liver disease (PLD) was admitted for right hypochondrial pain. CT showed a huge enhancing mass in the liver. She tested negative for other liver diseases, such as hepatitis B and C and alcoholic liver disease. After the patient expired due to hepatic failure, an autopsy revealed poorly differentiated hepatocellular carcinoma (HCC) surrounded by multiple hepatic cysts. The small amount of residual hepatic parenchyma showed nonalcoholic fatty liver disease (NAFLD) with severe steatosis. Severe emaciation was also apparent. This case suggests that malnutrition in patients with symptomatic PLD may contribute to the development of HCC via NAFLD.
authors.affiliation: Nephrology Center, Toranomon Hospital, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawada
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayami
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suwabe
authors.forename: Junichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sumida
authors.forename: Koki
authors.initials: K
authors.lastname: Mise
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hamanoue
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamanouchi
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Kenmei
authors.initials: K
authors.lastname: Takaichi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujii
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
mesh_terms: D001344:Autopsy; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D003560:Cysts / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D044342:Malnutrition / Q000150:complications / Q000473:pathology*; D008875:Middle Aged