title: Comparison of Porcine Small Intestinal Submucosa versus Polypropylene in Open Inguinal Hernia Repair: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  A systematic review and meta-analysis was performed in randomized controlled trials (RCTs) to compare porcine small intestinal submucosa (SIS) with polypropylene in open inguinal hernia repair.
  
  
  METHODS
  Electronic databases MEDLINE, Embase, and the Cochrane Library were used to compare patient outcomes for the two groups via meta-analysis.
  
  
  RESULTS
  A total of 3 randomized controlled trials encompassing 200 patients were included in the meta-analysis. There was no significant difference in recurrence (P = 0.16), hematomas (P = 0.06), postoperative pain within 30 days (P = 0.45), or postoperative pain after 1 year (P = 0.12) between the 2 groups. The incidence of discomfort was significantly lower (P = 0.0006) in the SIS group. However, the SIS group experienced a significantly higher incidence of seroma (P = 0.03).
  
  
  CONCLUSIONS
  Compared to polypropylene, using SIS in open inguinal hernia repair is associated with a lower incidence of discomfort and a higher incidence of seroma. However, well-designed larger RCT studies with a longer follow-up period are needed to confirm these findings.
authors.affiliation: Department of General Surgery, Shanghai Ninth Hospital affiliated to Shanghai JiaoTong University School of Medicine, and Hernia and Abdominal Wall Surgery Center of Shanghai JiaoTong University, Shanghai, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Nie
authors.affiliation: Department of Urology Surgery, Shanghai Ninth Hospital affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of General Surgery, Shanghai Ninth Hospital affiliated to Shanghai JiaoTong University School of Medicine, and Hernia and Abdominal Wall Surgery Center of Shanghai JiaoTong University, Shanghai, China.
authors.forename: Wenyue
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shanghai Ninth Hospital affiliated to Shanghai JiaoTong University School of Medicine, and Hernia and Abdominal Wall Surgery Center of Shanghai JiaoTong University, Shanghai, China.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of General Surgery, Shanghai Ninth Hospital affiliated to Shanghai JiaoTong University School of Medicine, and Hernia and Abdominal Wall Surgery Center of Shanghai JiaoTong University, Shanghai, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of General Surgery, Shanghai Ninth Hospital affiliated to Shanghai JiaoTong University School of Medicine, and Hernia and Abdominal Wall Surgery Center of Shanghai JiaoTong University, Shanghai, China.
authors.forename: Yuanwen
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Shanghai Ninth Hospital affiliated to Shanghai JiaoTong University School of Medicine, and Hernia and Abdominal Wall Surgery Center of Shanghai JiaoTong University, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000818:Animals; D016208:Databases, Factual; D006406:Hematoma / Q000209:etiology; D059685:Herniorrhaphy / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007421:Intestine, Small / Q000473:pathology*; D016017:Odds Ratio; D010149:Postoperative Pain; D011126:Polypropylenes; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D049291:Seroma / Q000209:etiology; D013526:Surgical Mesh; D013552:Swine; D016896:Treatment Outcome
chemical_list: D011126:Polypropylenes