title: Dissolvable base scaffolds allow tissue penetration of high-aspect-ratio flexible microneedles.
abstract: Microscale needle technology is important in electrophysiological studies, drug/chemical delivery systems, optogenetic applications, and so on. In this study, dissolvable needle-base scaffold realizes penetration of high-aspect-ratio flexible microneedles (e.g., <5 μm diameter and >500 μm length) into biological tissues. This methodology, which is applicable to numerous high-aspect-ratio flexible microneedles, should reduce the invasiveness and provide safer tissue penetrations than conventional approaches.
authors.affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yagi
authors.affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Yamagiwa
authors.affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kubota
authors.affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sawahata
authors.affiliation: Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.|Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Numano
authors.affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Imashioya
authors.affiliation: Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Oi
authors.affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.|Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ishida
authors.affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawano
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D051379:Mice; D055617:Micro-Electrical-Mechanical Systems; D008856:Microscopy, Fluorescence; D009339:Needles; D011092:Polyethylene Glycols / Q000737:chemistry; D012825:Silicon / Q000737:chemistry; D047011:Silk / Q000737:chemistry
chemical_list: D047011:Silk; D011092:Polyethylene Glycols; D012825:Silicon
keywords: brain; microneedles; penetration; silicon; silk