title: Silk as a potential candidate for bone tissue engineering.
abstract: Regeneration of large bone defects is challenging in the next few years because the age of the population is growing. Bone grafting as a gold standard of bone repairing is limited as a result of many disadvantages. In recent years, many novel materials and processing methods have been introduced to construct the native bone extracellular matrix (ECM) and restore the functions of degenerated bone. Silk fibroin (SF) as a natural polymer, has established a good reputation for bone tissue engineering applications due to its many unique properties, including exceptional biocompatibility, biodegradability, mechanical behavior, and ease of processability. In this review, recent advances in the design and application of SF-based scaffolds for bone regeneration are discussed.
authors.affiliation: Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mottaghitalab
authors.affiliation: Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
authors.forename: Hossein
authors.initials: H
authors.lastname: Hosseinkhani
authors.affiliation: National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Shokrgozar
authors.affiliation: Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK 73019, United States.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
authors.affiliation: Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058, PR China.
authors.forename: Mingying
authors.initials: M
authors.lastname: Yang
authors.affiliation: National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran. Electronic address: M_farokhi@pasteur.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Farokhi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000187:drug effects*; D006801:Humans; D047011:Silk; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D047011:Silk
keywords: Bone tissue engineering; Natural polymer; Scaffolds; Silk fibroin