title: Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis.
abstract: Catechol-O-methyltransferase (COMT) is a methylation enzyme engaged in the degradation of dopamine and noradrenaline by catalyzing the transfer of a methyl group from S-adenosylmethionine. An association was found between the Valine (Val) 108/158Methionine (Met) COMT polymorphism (rs4680) and major depressive disorder (MDD). The authors prospectively investigated the relationship between the Val108/158Met COMT genotype and voxel-based morphometry (VBM) findings for patients with first-episode and treatment-naïve MDD and healthy subjects (HS). Participants comprised 30 MDD patients and 48 age- and sex-matched HS who were divided according to the COMT genotype. Effects of diagnosis, COMT genotype, and the genotype-diagnosis interaction in relation to brain morphology in the Val/Met and Val/Val individuals were evaluated using a VBM analysis of high-resolution magnetic resonance imaging findings. Among the Val/Met individuals, the volume of the bilateral caudate was significantly smaller for MDD patients than for HS. In the Val/Val individuals, the caudate volume was comparable between MDD patients and HS. Significant genotype-diagnosis interaction effects on brain morphology were noted in the right caudate.
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan. Electronic address: sapient@med.uoeh-u.ac.jp.
authors.forename: Keita
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kakeda
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.affiliation: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Ide
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Katsuki
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene-Nakano
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Rieko
authors.initials: R
authors.lastname: Watanabe
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Yukunori
authors.initials: Y
authors.lastname: Korogi
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002421:Caudate Nucleus / Q000473:pathology; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D014633:Valine / Q000235:genetics*; D055815:Young Adult
chemical_list: D008715:Methionine; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase; D014633:Valine
keywords: Caudate; Major depressive disorder; VBM; Val108/158Met COMT