title: Hydrogenative Kinetic Resolution of Vinyl Sulfoxides.
abstract: Enantiopure sulfoxides are valuable precursors of organosulfur compounds with broad application in organic and pharmaceutical chemistry. An unprecedented strategy for obtaining highly enantioenriched sulfoxides based on a hydrogenative kinetic resolution using Rh-complexes of phosphine-phosphite ligands as catalysts is reported. After optimization, highly efficient conditions for the kinetic resolution of racemic sulfoxides have been identified. This methodology has been applied to a set of racemic aralkyl or aryl vinyl sulfoxides and allowed the isolation of both recovered and reduced products in excellent yields and enantioselectivities (up to 99% and 97% ee, respectively; 16 examples).
authors.affiliation: †Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona, Spain.
authors.forename: Joan R
authors.initials: JR
authors.lastname: Lao
authors.affiliation: †Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona, Spain.
authors.forename: Héctor
authors.initials: H
authors.lastname: Fernández-Pérez
authors.affiliation: †Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona, Spain.|‡Catalan Institution for Research and Advanced Studies (ICREA), P. Lluís Companys, 23, 08010 Barcelona, Spain.
authors.forename: Anton
authors.initials: A
authors.lastname: Vidal-Ferran