title: Interference of viral effector proteins with chromatin, transcription, and the epigenome.
abstract: Pathogens exploit cellular functions to create an environment conducive to their persistence and propagation. Viruses and bacteria express effector-proteins or virulence factors, known to interfere at the molecular level with regulatory 'checkpoints' of numerous physiological events in the cell. A newly prominent area of research is the identification of pathogenic effector proteins that function on the host chromatin, their subversion/interference with chromatin regulatory processes, the short/long/heritable effects on the infected cell and the ultimate consequence of their expression at the organismal level.
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Ivan.marazzi@mssm.edu.
authors.forename: Ivan
authors.initials: I
authors.lastname: Marazzi
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, NY, USA. Electronic address: Adolfo.garciasastre@mssm.edu.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Garcia-Sastre
mesh_terms: D002843:Chromatin / Q000187:drug effects*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D054884:Host-Pathogen Interactions; D014158:Transcription, Genetic / Q000187:drug effects*; D014764:Viral Proteins / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D002843:Chromatin; D014764:Viral Proteins; D037521:Virulence Factors