title: Short Communication: Exploring Antibody Potential as Prophylactic/Therapeutic Strategies for Prevention of Early Mucosal HIV-1 Infection.
abstract: Mucosal tissues are the predominant sites for genital HIV-1 transmission. We investigated the mechanisms by which broadly neutralizing antibodies (bNAbs) inhibit HIV-1 replication in a coculture model including primary mucosal dendritic cells (DCs), such as Langerhans cells, interstitial dendritic cells, and CD4(+) T lymphocytes. We show that bNAbs efficiently prevent HIV-1 infection by inhibiting HIV-1 transmission to CD4(+) T lymphocytes. This inhibition of cell-to-cell transmission was observed with equal potency as the inhibition of cell-free infection of primary CD4(+) T lymphocytes. In addition, a decrease in HIV-1 replication in DCs and the induction of DC maturation were detected. This additional inhibition was Fc mediated as it was blocked by the use of specific anti-FcγR monoclonal Abs. The DC maturation by bNAbs during HIV transmission may contribute to mucosal protection. Therefore, multiple antibody-mediated inhibitory functions should be combined for the improvement of future preventive/therapeutic strategies to cure HIV.
authors.affiliation: 1 INSERM UMR S_1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg, France .
authors.forename: Bin
authors.initials: B
authors.lastname: Su
authors.affiliation: 2 Centre d'investigation clinique/Service de neurologie, INSERM CIC-P1434, Hôpital de Hautepierre , Strasbourg, France .
authors.forename: Maryse
authors.initials: M
authors.lastname: Peressin
authors.affiliation: 1 INSERM UMR S_1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg, France .
authors.forename: Camille
authors.initials: C
authors.lastname: Ducloy
authors.affiliation: 1 INSERM UMR S_1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg, France .
authors.forename: Julien
authors.initials: J
authors.lastname: Penichon
authors.affiliation: 1 INSERM UMR S_1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg, France .
authors.forename: Luzia M
authors.initials: LM
authors.lastname: Mayr
authors.affiliation: 1 INSERM UMR S_1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg, France .
authors.forename: Géraldine
authors.initials: G
authors.lastname: Laumond
authors.affiliation: 1 INSERM UMR S_1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg, France .
authors.forename: Sylvie
authors.initials: S
authors.lastname: Schmidt
authors.affiliation: 1 INSERM UMR S_1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg, France .|3 Vaccine Research Institute, Hôpital Henri Mondor , Créteil, France .
authors.forename: Thomas
authors.initials: T
authors.lastname: Decoville
authors.affiliation: 1 INSERM UMR S_1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg, France .|3 Vaccine Research Institute, Hôpital Henri Mondor , Créteil, France .
authors.forename: Christiane
authors.initials: C
authors.lastname: Moog
mesh_terms: D057134:Antibodies, Neutralizing / Q000008:administration & dosage* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D015483:HIV Antibodies / Q000008:administration & dosage* / Q000276:immunology; D015658:HIV Infections / Q000517:prevention & control* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D008954:Models, Biological; D014779:Virus Replication / Q000187:drug effects
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies