title: [The use of Cinacalcet in chronic kidney disease: a case report].
abstract: Secondary Hyperparathyroidism is an important concurrent cause of cardiovascular and osteo-articular events, as well as, high morbidity and mortality for patients suffering from chronic kidney disease in conservative therapy and dialysis. The usual therapies, such as the vitamin D active metabolites and the phosphate binders did not always demonstrate effective in SHP control. New drugs, such as the calcimimetics, are available, resulting beneficial in highly reducing PTH levels. The only calcimimetic drug clinically used is cinacalcet, whose use is planned only in patients undergoing dialysis (peritoneal and extracorporeal). We describe the clinical case of a caucasian woman of 82 yrs old, with chronic kidney disease and secondary hyperparathyroidism resistant to usual therapies, in conservative treatment, which is prescribed cinacalcet (off-label). At first we found a worsening of the indices of renal function secondary to the effects of the drug on the hydrosaline balance. Increasing the hydrosaline intake we have seen the reduction and the subsequent stability of exams. Cinacalcet was effective in controlling the levels of parathyroid hormone and has contributed significantly to the achievement of optimal calcium-phosphorus balance. In view of these data, there is no doubt in taking in consideration the use of this drug also in the earliest stages of IRC.
authors.forename: Roberta
authors.initials: R
authors.lastname: Russo
authors.forename: Gennaro
authors.initials: G
authors.lastname: Argentino
authors.forename: Immacolata Daniela
authors.initials: ID
authors.lastname: Maresca
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Sannino
authors.forename: Andrea
authors.initials: A
authors.lastname: Memoli
authors.forename: Bruno
authors.initials: B
authors.lastname: Memoli
mesh_terms: D000369:Aged, 80 and over; D057966:Calcimimetic Agents / Q000627:therapeutic use*; D000069449:Cinacalcet / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy* / Q000209:etiology; D051436:Renal Insufficiency, Chronic / Q000150:complications
chemical_list: D057966:Calcimimetic Agents; D000069449:Cinacalcet