title: The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management.
abstract: BACKGROUND
  Cardiac arrest is not a uniform condition and significant heterogeneity exists within all victims with regard to the cause of cardiac arrest. Primary cardiac (dysrhythmic) and asphyxial causes together are responsible for most cases of cardiac arrest at all age groups. The purpose of this article is to review the pathophysiologic differences between dysrhythmic and asphyxial cardiac arrest in the prearrest period, during the no-flow state, and after successful cardiopulmonary resuscitation.
  
  
  METHODS
  The electronic databases of PubMed/Medline, Scopus, and Cochrane were searched for relevant literature and studies.
  
  
  CONCLUSIONS
  Significant differences exist between dysrhythmic and asphyxial cardiac arrest regarding their pathophysiologic pathways and affect consequently the postresuscitation period. Laboratory data indicate that asphyxial cardiac arrest leads to more widespread postresuscitation brain damage compared with dysrhythmic cardiac arrest. Regarding postresuscitation myocardial dysfunction, few studies have addressed a comparison of the 2 conditions with controversial results.
  
  
  CONCLUSIONS
  Asphyxial cardiac arrest differs significantly from dysrhythmic cardiac arrest with regard to pathophysiologic mechanisms, neuropathologic damage, postresuscitation organ dysfunction, and response to therapy. Both conditions should be considered and treated in a different manner.
authors.affiliation: Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address: dvarvar@hotmail.com.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Varvarousis
authors.affiliation: Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
authors.forename: Giolanda
authors.initials: G
authors.lastname: Varvarousi
authors.affiliation: Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Iacovidou
authors.affiliation: Forensic Science Unit, Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, 09042 Monserrato, Italy.
authors.forename: Ernesto
authors.initials: E
authors.lastname: D'Aloja
authors.affiliation: College of Pharmacy, Midwestern University, Downers Grove, IL.
authors.forename: Anil
authors.initials: A
authors.lastname: Gulati
authors.affiliation: Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece; College of Pharmacy, Midwestern University, Downers Grove, IL.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Xanthos
mesh_terms: D001145:Arrhythmias, Cardiac / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D001237:Asphyxia / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D006323:Heart Arrest / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D012151:Resuscitation