title: Molecular segmentation of luminal breast: Reality in 2015?
abstract: With the advent of next generation sequencing, we are beginning to get a clearer picture of the landscape of genetic alterations in primary breast cancer. One of the key findings has been the heterogeneity of mutational profiles, with no two primary breast tumors being alike. How these genetic alterations will help us manage patients is currently unclear. Studies are ongoing to determine which genetic alterations will signify "oncogenic addiction" and which ones will determine resistance and relapse to current standard therapies.
authors.affiliation: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: Zhi Ling
authors.initials: ZL
authors.lastname: Teo
authors.affiliation: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Electronic address: sherene.loi@petermac.org.
authors.forename: Sherene
authors.initials: S
authors.lastname: Loi
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics*; D058534:Class I Phosphatidylinositol 3-Kinases; D004252:DNA Mutational Analysis; D047628:Estrogen Receptor alpha / Q000235:genetics; D005260:Female; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics
chemical_list: D058534:Class I Phosphatidylinositol 3-Kinases; D047628:Estrogen Receptor alpha; D019869:Phosphatidylinositol 3-Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1; C506487:ESR1 protein, human; C484760:PIK3CA protein, human; C508053:ERBB2 protein, human; C496348:FGFR1 protein, human
keywords: Biomarkers; Breast cancer; Genetic alterations; Prognosis; Sequencing