title: CholesteroNitrones for Stroke.
abstract: This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke.
authors.affiliation: Department of Investigation, Hospital Ramón y Cajal, IRYCIS , Madrid 28034, Spain.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Ayuso
authors.affiliation: Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC) , Juan de la Cierva 3, Madrid 29006, Spain.
authors.forename: Mourad
authors.initials: M
authors.lastname: Chioua
authors.affiliation: Department of Investigation, Hospital Ramón y Cajal, IRYCIS , Madrid 28034, Spain.
authors.forename: Emma
authors.initials: E
authors.lastname: Martínez-Alonso
authors.affiliation: SEPCO, Institute of Organic Chemistry General (CSIC) , Madrid 28006, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Soriano
authors.affiliation: Institut de Recerca Vall d'Hebron, Universidad Autònoma de Barcelona and Hospital Vall d'Hebron , Barcelona 08035, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Montaner
authors.affiliation: Department of Neurology, Hospital Ramón y Cajal, IRYCIS , Madrid 28034, Spain.
authors.forename: Jaime
authors.initials: J
authors.lastname: Masjuán
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Health Sciences, Aristotle University of Thessaloniki , Thessaloniki 54124, Greece.
authors.forename: Dimitra J
authors.initials: DJ
authors.lastname: Hadjipavlou-Litina
authors.affiliation: Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC) , Juan de la Cierva 3, Madrid 29006, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Marco-Contelles
authors.affiliation: Department of Investigation, Hospital Ramón y Cajal, IRYCIS , Madrid 28034, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Alcázar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D002545:Brain Ischemia / Q000188:drug therapy*; D016923:Cell Death / Q000187:drug effects; D002478:Cells, Cultured; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000523:psychology; D009422:Nervous System Diseases / Q000517:prevention & control / Q000523:psychology; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009589:Nitrogen Oxides / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017382:Reactive Oxygen Species; D015427:Reperfusion Injury / Q000188:drug therapy; D020521:Stroke / Q000188:drug therapy*; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D009589:Nitrogen Oxides; D017382:Reactive Oxygen Species; C000602650:cholesteronitrone; C015388:nitrones; D002784:Cholesterol