title: Synergy of two human endogenous retroviruses in multiple myeloma.
abstract: Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate the risk of MM with endogenous retroviral loci in humans. We used SNP analysis on a Sequenom platform and statistical analysis in SPSS. Markers near two endogenous retroviral loci, HERV-Fc1 on chromosome X and HERV-K on chromosome 1, were associated with MM. Moreover, there was strong gene-gene interaction in relation to risk of MM. We take this as indirect confirmation of the association.
authors.affiliation: Department of Biomedicin, Aarhus University, DK-8000 Aarhus C, Denmark.
authors.forename: Kathrine L M
authors.initials: KL
authors.lastname: Schmidt
authors.affiliation: Department of Hematology, Rigshospitalet, Copenhagen University, DK-2100 Copenhagen, Denmark.
authors.forename: Annette J
authors.initials: AJ
authors.lastname: Vangsted
authors.affiliation: Department of Biomedicin, Aarhus University, DK-8000 Aarhus C, Denmark.
authors.forename: Bettina
authors.initials: B
authors.lastname: Hansen
authors.affiliation: National Institute of Occupational Health, DK-2100 Copenhagen O, Denmark.
authors.forename: Ulla B
authors.initials: UB
authors.lastname: Vogel
authors.affiliation: Department of Hematology, Rigshospitalet, Copenhagen University, DK-2100 Copenhagen, Denmark.
authors.forename: N Emil U
authors.initials: NE
authors.lastname: Hermansen
authors.affiliation: Department of Biomedicin, Aarhus University, DK-8000 Aarhus C, Denmark.
authors.forename: Sara B
authors.initials: SB
authors.lastname: Jensen
authors.affiliation: Department of Biomedicin, Aarhus University, DK-8000 Aarhus C, Denmark.
authors.forename: Magdalena J
authors.initials: MJ
authors.lastname: Laska
authors.affiliation: Department of Biomedicin, Aarhus University, DK-8000 Aarhus C, Denmark. Electronic address: nexo@biomed.au.dk.
authors.forename: Bjørn A
authors.initials: BA
authors.lastname: Nexø
mesh_terms: D020077:Endogenous Retroviruses / Q000235:genetics*; D004843:Epistasis, Genetic; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000235:genetics* / Q000821:virology*; D020641:Polymorphism, Single Nucleotide
keywords: Genetic epidemiology; Gene–gene interaction; HERV; Human endogenous retrovirus; Myelomatosis