title: [Desensitization to darunavir in a pediatric patient].
abstract: Treatment of HIV infection requires the combination of multiple antiretroviral drugs, known as highly active antiretroviral therapy (HAART); however, up to 84% of patients experience adverse drug effects that lead to discontinuation within first months of treatment. Skin manifestations are reported to 22% of patients. The severity of these is variable, such as erythema multiforme, rash, hives and severe skin reactions at less than 2%. Mild rashes, usually transient and self-limiting, while severe reactions require immediately remove the drug involved to prevent progression of the reaction. Only in those cases where the offending drug does not have another alternative and documented the reaction is mediated type I hypersensitivity mechanisms, can be performed desensitization protocol.
authors.affiliation: Departamento de Alergia e Inmunología Clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. jcesar_963@hotmail.com.
authors.forename: Julio César
authors.initials: JC
authors.lastname: Cambray-Gutiérrez
authors.forename: Patricia
authors.initials: P
authors.lastname: López-Pérez
authors.forename: Aurora Alejandra
authors.initials: AA
authors.lastname: Chávez-García
authors.forename: Leonel Gerardo
authors.initials: LG
authors.lastname: Del Rivero-Hernández
authors.forename: Nora Hilda
authors.initials: NH
authors.lastname: Segura-Méndez
keywords: HAART; adverse reactions; desensitization