title: An Advanced Bolus Calculator for Type 1 Diabetes: System Architecture and Usability Results.
abstract: This paper presents the architecture and initial usability results of an advanced insulin bolus calculator for diabetes (ABC4D), which provides personalized insulin recommendations for people with diabetes by differentiating between various diabetes scenarios and automatically adjusting its parameters over time. The proposed platform comprises two main components: a smartphone-based patient platform allowing manual input of glucose and variables affecting blood glucose levels (e.g., meal carbohydrate content and exercise) and providing real-time insulin bolus recommendations; and a clinical revision platform to supervise the automatic adaptations of the bolus calculator parameters. The system implements a previously in silico validated bolus calculator algorithm based on case-based reasoning, which uses information from similar past events (i.e., cases) to suggest improved personalized insulin bolus recommendations and automatically learns from new events. Usability of ABC4D was assessed by analyzing the system usage at the end of a six-week pilot study (n = 10). Further feedback on the use of ABC4D has been obtained from each participant at the end of the study from a usability questionnaire. On average, each participant requested 115 ± 21 insulin recommendations, of which 103 ± 28 (90%) were accepted. The clinical revision software proposed a total of 754 case revisions, where 723 (96%) adaptations were approved by a clinical expert and updated in the patient platform.
authors.forename: Peter
authors.initials: P
authors.lastname: Pesl
authors.forename: Pau
authors.initials: P
authors.lastname: Herrero
authors.forename: Monika
authors.initials: M
authors.lastname: Reddy
authors.forename: Maria
authors.initials: M
authors.lastname: Xenou
authors.forename: Nick
authors.initials: N
authors.lastname: Oliver
authors.forename: Desmond
authors.initials: D
authors.lastname: Johnston
authors.forename: Christofer
authors.initials: C
authors.lastname: Toumazou
authors.forename: Pantelis
authors.initials: P
authors.lastname: Georgiou
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis*; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use*; D063731:Mobile Applications; D017060:Patient Satisfaction; D000068997:Smartphone; D014584:User-Computer Interface
chemical_list: D001786:Blood Glucose; D007328:Insulin