title: Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study.
abstract: In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of faster operation speed due to photoacoustic time-of-flight measurement and guidance, compared with the conventional depth-resolved Raman spectroscopy method. In addition, further combination with advanced optical-focusing techniques in biological-scattering medium could potentially enable the proposed approach for cancer diagnostics with both tight and fast optical focusing at the desired depth of tumor.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.forename: Yi Hong
authors.initials: YH
authors.lastname: Ong
authors.forename: Gaoming
authors.initials: G
authors.lastname: Li
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Feng
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.forename: Yuanjin
authors.initials: Y
authors.lastname: Zheng