title: Utility of Y-Chromosome Short Tandem Repeat Haplotypes in Forensic Applications.
abstract: Patrilineally transmitted Y-chromosomal markers have been shown to resolve forensic cases under certain scenarios where autosomal markers provide limited or inconclusive evidence. Several Y-short tandem repeat (Y-STR) loci have been validated for forensic use, and Y-STR haplotype databases for a number of geographic locations are now available in the literature and online. In this review, examples are presented of situations where Y-STR loci can provide valuable supplemental forensic evidence when autosomal STR loci fail or provide little evidence. Also, different methods of interpreting Y-STR forensic evidence in casework analysis are outlined, suggesting that in spite of excessive conservativeness, the counting method is still the most simple and easily defensible method of interpreting Y-STR forensic evidence. While the need for developing more powerful interpretation methods should be considered, it is stressed that expansion of Y-STR databases should focus on increasing sample sizes and the inclusion of more anthropologically defined populations to improve the efficiency of interpretation of Y-STR markers in forensic applications.
authors.affiliation: Laboratory Division, Federal Bureau of Investigation, Quantico, VA, USA.
authors.forename: B
authors.initials: B
authors.lastname: Budowle
authors.affiliation: ReliaGene Technologies, Inc., New Orleans, LA, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Sinha
authors.affiliation: Center for Genome Information, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Center for Genome Information, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: R
authors.initials: R
authors.lastname: Chakraborty
keywords: DNA forensics; Y-Chromosome markers; counting method; haplotypes; match probability; population substructure; short tandem repeats