title: Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging.
abstract: Silver nanoparticles have been successfully applied as a matrix replacement for the laser desorption/ionization time-of-flight mass spectrometry (LDI-ToF-MS). Nanoparticles, producing spectra with highly reduced chemical background in the low m/z region, are perfectly suited for low-molecular weight compound analysis and imaging. Silver nanoparticles (AgNPs) can efficiently absorb ultraviolet laser radiation, transfer energy to the analyte and promote analyte desorption, but also constitute a source of silver ions suitable for analyte cationisation. This review provides an overview of the literature on silver nanomaterials as non-conventional desorption and ionization promoters in LDI-MS and mass spectrometry imaging.
authors.affiliation: Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland. tomruman@prz.edu.pl.
authors.forename: Justyna
authors.initials: J
authors.lastname: Sekuła
authors.forename: Joanna
authors.initials: J
authors.lastname: Nizioł
authors.forename: Wojciech
authors.initials: W
authors.lastname: Rode
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ruman
mesh_terms: D000818:Animals; D006801:Humans; D053768:Metal Nanoparticles; D008829:Microbiology; D057054:Molecular Imaging / Q000379:methods*; D012834:Silver / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D012834:Silver