title: Resveratrol metabolite profiling in clinical nutrition research--from diet to uncovering disease risk biomarkers: epidemiological evidence.
abstract: Resveratrol is a bioactive plant compound that has drawn scientific and media attention owing to its protective effects against a wide variety of illnesses, including cardiovascular diseases and cancer. In the last two decades, a plethora of preclinical studies have shown these beneficial effects, and some of them have been supported by clinical trials. However, there are few epidemiological studies assessing these relationships, showing mostly inconsistent results among them. This could be partially due to the difficulty of accurately estimating dietary resveratrol exposure. The development of Phenol-Explorer, a database containing resveratrol food-composition data, will facilitate the estimation of resveratrol intake. Moreover, the discovery and validation of a nutritional biomarker of this exposure, urinary resveratrol metabolite profile, will allow a more accurate assessment of dietary resveratrol exposure. Few epidemiological studies have assessed the potential health effects of resveratrol. Resveratrol was not associated with total mortality, cancer, or cardiovascular events, but it was associated with an improvement of serum glucose and triglyceride levels and a decrease in heart rate. Together, these findings suggest a potential cardioprotective effect of resveratrol in epidemiological studies, although the evidence is still scarce.
authors.affiliation: Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Rabassa
authors.affiliation: Nutrition and Metabolism Section (NME), Biomarkers Group (BMA), International Agency for Research on Cancer (IARC), Lyon, France.
authors.forename: Raul
authors.initials: R
authors.lastname: Zamora-Ros
authors.affiliation: Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Urpi-Sarda
authors.affiliation: Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Andres-Lacueva
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000652:urine; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D004032:Diet; D006801:Humans; D015596:Nutrition Assessment; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*
chemical_list: D015415:Biomarkers; D002316:Cardiotonic Agents; D013267:Stilbenes; D000077185:Resveratrol
keywords: biomarker; cardiovascular disease; diet; epidemiology; mortality; resveratrol