title: Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation.
abstract: OBJECTIVE
  To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy.
  
  
  METHODS
  We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy.
  
  
  RESULTS
  There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78).
  
  
  CONCLUSIONS
  Oophorectomy is not associated with significant weight gain in high-risk women.
authors.affiliation: Women's College Research Institute, 790 Bay Street, Room 750, Toronto, ON, M5G 1N8, Canada.
authors.forename: Joanne
authors.initials: J
authors.lastname: Kotsopoulos
authors.affiliation: Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.affiliation: City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Neuhausen
authors.affiliation: Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
authors.affiliation: Department of Preventive Medicine & Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.
authors.forename: Henry T
authors.initials: HT
authors.lastname: Lynch
authors.affiliation: Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Huzarski
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Toronto, 123 Edward St, Toronto, ON, M5G 1E2, Canada.
authors.forename: Rochelle
authors.initials: R
authors.lastname: Demsky
authors.affiliation: Program in Cancer Genetics, Department of Oncology & Human Genetics, McGill University, 3755 Côte Ste-Catherine, Montreal, QC, H3T 1E2, Canada.
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
authors.affiliation: Division of Human Genetics, The Ohio State University Medical Center, Comprehensive Cancer Center, 460 W 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Leigha
authors.initials: L
authors.lastname: Senter
authors.affiliation: Moffitt Cancer Center, Departments of Cancer Epidemiology, Biostatistics, Anatomic Pathology, & Experimental Therapeutics, 12902 Magnolia Drive, Tampa, FL 33612, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Friedman
authors.affiliation: London Regional Cancer Program, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Ainsworth
authors.affiliation: Women's College Research Institute, 790 Bay Street, Room 750, Toronto, ON, M5G 1N8, Canada.
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.affiliation: Women's College Research Institute, 790 Bay Street, Room 750, Toronto, ON, M5G 1N8, Canada.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001835:Body Weight; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010052:Ovariectomy / Q000706:statistics & numerical data*; D011446:Prospective Studies; D012307:Risk Factors; D015430:Weight Gain; D016387:Women's Health
keywords: BRCA1; BRCA2; oophorectomy; weight gain