title: Current progress in the biology of members of the Sporothrix schenckii complex following the genomic era.
abstract: Sporotrichosis has been attributed for more than a century to one single etiological agent, Sporothrix schencki. Only eight years ago, it was described that, in fact, the disease is caused by several pathogenic cryptic species. The present review will focus on recent advances to understand the biology and virulence of epidemiologically relevant pathogenic species of the S. schenckii complex. The main subjects covered are the new clinical and epidemiological aspects including diagnostic and therapeutic challenges, the development of molecular tools, the genome database and the perspectives for study of virulence of emerging Sporothrix species.
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, CP 36050, Guanajuato, Gto., México.
authors.forename: Héctor M
authors.initials: HM
authors.lastname: Mora-Montes
authors.affiliation: Laboratório de Micologia Celular e Proteômica, Universidade do Estado do Rio de Janeiro (UERJ), CEP 20550-013 Rio de Janeiro, RJ, Brazil.
authors.forename: Alessandra da Silva
authors.initials: Ada S
authors.lastname: Dantas
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, CP 36050, Guanajuato, Gto., México.
authors.forename: Elías
authors.initials: E
authors.lastname: Trujillo-Esquivel
authors.affiliation: Laboratório de Micologia Médica e Molecular, Universidade Federal Fluminense (UFF), CEP 24210-130 Niterói, RJ, Brazil.
authors.forename: Andrea R
authors.initials: AR
authors.lastname: de Souza Baptista
authors.affiliation: Laboratório de Micologia Celular e Proteômica, Universidade do Estado do Rio de Janeiro (UERJ), CEP 20550-013 Rio de Janeiro, RJ, Brazil lmlb23@globo.com.
authors.forename: Leila M
authors.initials: LM
authors.lastname: Lopes-Bezerra
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D016681:Genome, Fungal; D006801:Humans; D025202:Molecular Diagnostic Techniques; D013175:Sporothrix / Q000235:genetics* / Q000502:physiology*; D013174:Sporotrichosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D037521:Virulence Factors
keywords: Sporothrix brasiliensis; Sporothrix globosa; Sporothrix schenckii; genome; molecular tools; pathogenesis