title: STMN1 overexpression correlates with biological behavior in human cutaneous squamous cell carcinoma.
abstract: Stathmin 1 (STMN1) is an important molecule in regulating cellular microtubule dynamics and promoting microtubule depolymerization in interphase and late mitosis. Evidences showed that STMN1 was up-regulated in many cancers, but there was no report about the roles of STMN1 in human cutaneous squamous cell carcinoma (cSCC). Here, we confirmed significant upregulation of STMN1 in cSCC tissues and cell lines compared with non-tumor counterparts. STMN1 upregulation was associated with the proliferation, migration, invasion and apoptosis of cSCC cells. The results suggested that STMN1 may play an important role in the development and tumor progression of cSCC.
authors.affiliation: Department of Pathological Anatomy, Medical School of Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Xingyu
authors.initials: X
authors.lastname: Li
authors.affiliation: Nantong Municipal Center for Disease Control and Prevention, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathological Anatomy, Medical School of Nantong University, Nantong, Jiangsu 226001, People's Republic of China; Small RNA Technology and Application Institute, Nantong University, Nantong, Jiangsu 226016, People's Republic of China.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Li
authors.affiliation: Medical School of Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: You
authors.affiliation: Medical School of Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Medical School of Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Si
authors.initials: S
authors.lastname: Shi
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People's Republic of China. Electronic address: ntqianli@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Pathological Anatomy, Medical School of Nantong University, Nantong, Jiangsu 226001, People's Republic of China. Electronic address: xiaolei@ntu.edu.cn.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Cao
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D034741:RNA, Small Interfering; D060888:Real-Time Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000473:pathology*; D050777:Stathmin / Q000032:analysis / Q000096:biosynthesis*; D014162:Transfection; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D034741:RNA, Small Interfering; C493995:STMN1 protein, human; D050777:Stathmin
keywords: A431; Cutaneous squamous cell carcinoma (cSCC); Stathmin 1 (STMN1); siRNA