title: Prognostic value of IGF-1R expression in bone and soft tissue sarcomas: a meta-analysis.
abstract: Accumulated evidence has indicated a correlation between IGF-1R and bone and soft tissue sarcoma (BSTS) progression. However, research on the prognostic role of IGF-1R in sarcomas has revealed very different or even totally opposite results. This meta-analysis aimed to unveil the controversial role IGF-1R plays in predicting the outcome of BSTS patients. We systematically reviewed the evidence for the effect of IGF-1R expression in multiple types of BSTSs, including osteosarcoma, Ewing's sarcoma, synovial sarcoma, liposarcoma, and rhabdomyosarcoma, to elucidate this issue. The prognostic value of IGF-1R expression in BSTS patients was evaluated regarding overall survival, measured by pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Seven studies including 627 patients were enrolled in this meta-analysis. Our results demonstrated that IGF-1R expression was associated with poor outcome in terms of overall survival in BSTS patients (pooled HR =2.15, 95% CI: 1.06-4.38; P=0.03). In subtypes of BSTSs, elevated IGF-1R expression was revealed to be significantly correlated with worse prognosis in osteosarcoma (pooled HR =2.20, 95% CI: 1.59-0.03; P<0.001), while no statistical significance was discovered in Ewing's sarcoma (pooled HR =1.01, 95% CI: 0.45-2.27; P=0.99). Expression of IGF-1R could be a negative prognostic biomarker for patients suffering from BSTSs.
authors.affiliation: School of Clinical Medicine, Wenzhou Medical University, Wenzhou, People's Republic of China ; Department of Orthopedics, Taizhou Hospital, Taizhou, People's Republic of China.
authors.forename: Junbo
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Orthopaedics, Institute of Orthopaedic Research, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Binghao
authors.initials: B
authors.lastname: Li
authors.affiliation: School of Public Health, Fudan University, Shanghai, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Orthopaedics, Institute of Orthopaedic Research, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Ye
keywords: IGF-1R; meta-analysis; overall survival; prognostic significance osteosarcoma