title: Subcutaneous administration of paclitaxel in dogs with cancer: A preliminary study.
abstract: Intravenous paclitaxel has been underused in dogs due to severe and acute hypersensitivity reactions. Subcutaneous (SC) administration of paclitaxel and its safety are unknown. In this preliminary study, SC administration of paclitaxel was evaluated for hypersensitivity reactions and toxicity in 21 dogs with advanced cancer. Dogs received 1 to 5 paclitaxel doses, ranging from 85 to 170 mg/m(2), SC every 14 or 21 days. A total of 40 paclitaxel doses were administered and none of the 21 dogs developed systemic or acute local hypersensitivity reactions. Severe skin lesions at the injection site developed in 2 dogs after the 4th injection at the same location. Grade 4 neutropenia was observed in 50% of the dogs 5 days after the first treatment at 115 mg/m(2) (n = 14). Two animals developed Grade 5 diarrhea and died likely due to hemodynamic failure or sepsis. Paclitaxel can be administered SC in dogs with no hypersensitivity reaction.
authors.affiliation: Small Animal Oncology Service, Veterinary Teaching Hospital, Department of Veterinary Medicine, Federal University of Parana, Rua dos Funcionários 1540, 80035-050, Curitiba, Paraná, Brazil.
authors.forename: Daniella M
authors.initials: DM
authors.lastname: Silva
authors.affiliation: Small Animal Oncology Service, Veterinary Teaching Hospital, Department of Veterinary Medicine, Federal University of Parana, Rua dos Funcionários 1540, 80035-050, Curitiba, Paraná, Brazil.
authors.forename: Aline I
authors.initials: AI
authors.lastname: Franciosi
authors.affiliation: Small Animal Oncology Service, Veterinary Teaching Hospital, Department of Veterinary Medicine, Federal University of Parana, Rua dos Funcionários 1540, 80035-050, Curitiba, Paraná, Brazil.
authors.forename: Paula C F
authors.initials: PC
authors.lastname: Pezzini
authors.affiliation: Small Animal Oncology Service, Veterinary Teaching Hospital, Department of Veterinary Medicine, Federal University of Parana, Rua dos Funcionários 1540, 80035-050, Curitiba, Paraná, Brazil.
authors.forename: Simone D
authors.initials: SD
authors.lastname: Guérios
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007279:Injections, Subcutaneous; D008223:Lymphoma / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D034801:Mastocytoma / Q000188:drug therapy / Q000662:veterinary*; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D017239:Paclitaxel