title: Determined to Fail--the Role of Genetic Mechanisms in Heart Failure.
abstract: Genetic variants contribute to several steps during heart failure pathophysiology. The mechanisms include frequent polymorphisms that increase the susceptibility to heart failure in the general population and rare variants as causes of an underlying cardiomyopathy. In this review, we highlight recent discoveries made by genetic approaches and provide an outlook onto the role of epigenetic modifiers of heart failure.
authors.affiliation: Institute for Cardiomyopathies Heidelberg (ICH), Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.|DZHK (German Centre for Cardiovascular Research), Berlin, Germany.
authors.forename: Elham
authors.initials: E
authors.lastname: Kayvanpour
authors.affiliation: Institute for Cardiomyopathies Heidelberg (ICH), Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.|DZHK (German Centre for Cardiovascular Research), Berlin, Germany.
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Katus
authors.affiliation: Institute for Cardiomyopathies Heidelberg (ICH), Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. Benjamin.meder@med.uni-heidelberg.de.|DZHK (German Centre for Cardiovascular Research), Berlin, Germany. Benjamin.meder@med.uni-heidelberg.de.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Meder
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000235:genetics; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006333:Heart Failure / Q000209:etiology / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012084:Renin-Angiotensin System / Q000235:genetics
keywords: Cardiomyopathy; Gene mutation; Genetic polymorphism; Heart failure