title: [Clinical analysis of sudden deafness after radiotherapy and chemotherapy in nasopharyngeal carcinoma patients].
abstract: OBJECTIVE
  To investigate the clinical features and therapeutic effects of sudden deafness after radiotherapy combined with chemotherapy in nasopharyngeal carcinoma patients.
  
  
  METHODS
  Clinical data of 42 nasopharyngeal carcinoma patients suffered from sudden deafness after radiotherapy combined with chemotherapy were analyzed retrospectively. Among the 42 patients, 2 showed moderate deafness, 4 presented excessive deafness, 30 suffered from severe deafness, and 6 exhibited profound deafness. The audiogram pattern of 33 patients met with the type of high tone frequencies hearing loss, and that of the rest 9 cases showed hearing loss at all frequencies. All patients received medical therapy combined with hyperbaric oxygen therapy.
  
  
  RESULTS
  Of all the cases with hearing loss, 2 were cured, 2 showed excellent recovery, 9 came out partial recovery, and 29 showed no response to the treatment. The total effective rate was 30.95%. For the accompanied symptoms, none of the 30 cases of tinnitus were relieved, 3 out of 10 cases of aural fullness were cured, and the 5 cases of dizziness or vertigo were all improved.
  
  
  CONCLUSIONS
  The sudden deafness after radiotherapy combined with chemotherapy in patients with nasopharyngeal carcinoma is closely related to radiotherapy. The hearing loss is serious, and the therapeutic effects are not satisfactory.
authors.forename: Liangzhong
authors.initials: L
authors.lastname: Yao
authors.forename: Junjie
authors.initials: J
authors.lastname: Liu
authors.forename: Zhiling
authors.initials: Z
authors.lastname: Pan
authors.forename: Xiangning
authors.initials: X
authors.lastname: Yang
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002277:Carcinoma; D004244:Dizziness / Q000209:etiology / Q000628:therapy; D006316:Hearing Loss, High-Frequency / Q000209:etiology / Q000628:therapy; D003639:Hearing Loss, Sudden / Q000209:etiology* / Q000628:therapy; D006320:Hearing Tests; D006801:Humans; D006931:Hyperbaric Oxygenation; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D014012:Tinnitus / Q000209:etiology / Q000628:therapy; D014717:Vertigo / Q000209:etiology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents