title: Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis.
abstract: OBJECTIVE
  To evaluate the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis.
  
  
  METHODS
  Case-control studies evaluating CA125, CA19-9 and CA15-3 and endometriosis, published between January 2000 and November 2014 were retrieved from PubMed(®) and Google Scholar. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated. Subgroup analyses were carried out by ethnicity and disease stage (early, stage I/II; advanced, stage III/IV).
  
  
  RESULTS
  The analysis included 12 case-control studies (963 cases, 855 controls). CA125 was associated with endometriosis in the overall population (SMD 0.82, 95% CI 0.72, 0.92), Caucasian subgroup (SMD 1.08, 95% CI 0.96, 1.19), and early (SMD 1.20, 95% CI 0.93, 1.48) or advanced disease (SMD 1.29, 95% CI 1.04, 1.55). CA19-9 was associated with endometriosis in the overall population (SMD 0.48, 95% CI 0.24, 0.72), Caucasian subgroup (SMD 0.31, 95% CI 0.07, 0.55), Asian subgroup (SMD 9.65, 95% CI 7.88, 11.42) and advanced disease (SMD 0.60, 95% CI 0.34, 0.87). CA15-3 was significantly associated with advanced disease (SMD 0.47, 95% CI 0.09, 0.84).
  
  
  CONCLUSIONS
  Serum CA125 and CA19-9 may represent useful biomarkers for the noninvasive diagnosis of endometriosis.
authors.affiliation: Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China shenairzhzh@126.com.
authors.forename: Airong
authors.initials: A
authors.lastname: Shen
authors.affiliation: Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China.
authors.forename: Yange
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China.
authors.forename: Canyu
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China.
authors.forename: Shunhong
authors.initials: S
authors.lastname: Zou
mesh_terms: D044466:Asian People; D018394:CA-125 Antigen / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D004715:Endometriosis / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D018396:Mucin-1 / Q000097:blood*; D044465:White People
chemical_list: D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D018396:Mucin-1
keywords: CA125; CA15-3; CA19-9; endometriosis; meta-analysis