title: Do not scratch that mole!
abstract: Nevi harbor some of the same oncogene mutations that also drive malign melanoma. Further tumor promoting events are required to unleash their carcinogenic potential. Using zebrafish whose melanocytes overexpress an HRAS-oncogene, a new study reports that injury induces melanoma, possibly through recruitment of neutrophils that trigger proliferation of preneoplastic melanocytes.
authors.affiliation: Cell Biology Program, Memorial Sloan Kettering Cancer Center, 411 E 67th Street, New York, NY 10065, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Jelcic
authors.affiliation: Cell Biology Program, Memorial Sloan Kettering Cancer Center, 411 E 67th Street, New York, NY 10065, USA. Electronic address: niethamp@mskcc.org.
authors.forename: Philipp
authors.initials: P
authors.lastname: Niethammer
mesh_terms: D000818:Animals; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology*; D011230:Precancerous Conditions / Q000276:immunology*; D014947:Wounds and Injuries / Q000276:immunology*; D015027:Zebrafish / Q000276:immunology*