title: [Differences by age in clinical features of inflammatory bowel disease].
abstract: BACKGROUND
  Approximately, 15% of patients with Inflammatory Bowel Disease (IBD) are diagnosed at 60 years of age or more.
  
  
  OBJECTIVE
  To characterize and compare clinical variables between patients with IBD aged 60 years or more and their younger counterparts.
  
  
  METHODS
  Retrospective study based on a registry of IBD patients diagnosed between the years 1976 and 2014.
  
  
  RESULTS
  Four hundred and nine IBD patients were included. Among them, 294 had Ulcerative Colitis (UC), 104 had Crohn's Disease (CD) and eleven had an indeterminate IBD. Forty-six patients (11.2%) were older than 60 years and 16 (3.9%) had been diagnosed after this age. When comparing patients by age, those aged 60 years or more had a higher frequency of CD and indeterminate IBD (p < 0.01) and a lower ileocolic location in CD (p = 0.02). Both groups were similar in terms of hospitalization due to IBD flare, surgery, use of steroids, immunosuppressive or biological therapies and drug-related adverse events. When analyzing age at diagnosis of IBD, patients diagnosed at ages of 60 years or more had a lower frequency of UC (p < 0.01), a higher frequency of exclusive colonic involvement (p = 0.01), and lower use of mesalamine (p < 0.01). There were no differences in drug-related adverse events, hospitalizations due to IBD flares and surgery according to age at diagnosis.
  
  
  CONCLUSIONS
  In this population, clinical features of IBD in older patients were similar to those in younger patients.
authors.forename: Daniela
authors.initials: D
authors.lastname: Simian
authors.forename: Camila
authors.initials: C
authors.lastname: Estay
authors.forename: Udo
authors.initials: U
authors.lastname: Kronberg
authors.forename: Andrés
authors.initials: A
authors.lastname: Yarur
authors.forename: Magdalena
authors.initials: M
authors.lastname: Castro
authors.forename: Jaime
authors.initials: J
authors.lastname: Lubascher
authors.forename: Raúl
authors.initials: R
authors.lastname: Acuña
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Quera
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000175:diagnosis; D003424:Crohn Disease / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents