title: Copper Catalyzed Enantioselective Alkylation of Pyrrole with β,γ-Unsaturated α-Ketoesters: Application to One-Pot Construction of the Seven-Membered Ring by Merging a Gold Catalysis.
abstract: A highly enantioselective Friedel-Crafts alkylation of pyrrole to β,γ-unsaturated α-ketoesters was developed by virtue of a chiral copper complex, affording the alkylated derivatives of pyrrole with good yields and excellent enantioselectivities. Moreover, merging copper catalysis with gold catalysis realized a one-pot construction of the seven-membered ring to give annulated pyrroles with moderate to good yields and high enantiomeric excesses.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Hu
authors.forename: Yanan
authors.initials: Y
authors.lastname: Li
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Chong
authors.initials: C
authors.lastname: Li
authors.forename: Lijun
authors.initials: L
authors.lastname: Li
authors.forename: Zhenggen
authors.initials: Z
authors.lastname: Zha
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang