title: Scapairrins A-Q, Labdane-Type Diterpenoids from the Chinese Liverwort Scapania irrigua and Their Cytotoxic Activity.
abstract: Seventeen new labdane-type diterpenoids, scapairrins A-Q (1-17), including six pairs of diastereoisomers, and three known analogues (18-20) were isolated from the Chinese liverwort Scapania irrigua. The structures of 1-17 were determined based on a combination of the analysis of their MS and NMR spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Cytotoxicity testing showed that compounds 7-10 exhibited inhibitory activities against a small panel of human cancer cell lines.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Jiaozhen
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250010, People's Republic of China.
authors.forename: Rongxiu
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Jinchuan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: School of Chemistry and Chemical Engineering, University of Jinan , Jinan 250022, People's Republic of China.
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
mesh_terms: D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C433017:labdane