title: Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications.
abstract: An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from the body within a reasonable timescale. However, the integration of diagnostic and therapeutic components into a single ultrasmall nanoparticle remains challenging. In this study, pH-activated nanodots (termed Fe-CPNDs) composed of coordination polymers were synthesized via a simple and scalable method based on coordination reactions among Fe(3+), gallic acid and poly(vinylpyrrolidone) at ambient conditions. The Fe-CPNDs exhibited ultrasmall (5.3 nm) hydrodynamic diameters and electrically neutral surfaces. The Fe-CPNDs also exhibited pH-activatable magnetic resonance imaging contrast and outstanding photothermal performance. The features of Fe-CPNDs greatly increased the tumour-imaging sensitivity and facilitated renal clearance after injection in animal models in vivo. Magnetic resonance imaging-guided photothermal therapy using Fe-CPNDs completely suppressed tumour growth. These findings demonstrate that Fe-CPNDs constitute a new class of renal clearable nanomedicine for photothermal therapy and molecular imaging.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.|University of Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Fuyao
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Biological Engineering, School of Life Science and Technology, Changchun University of Science and Technology, Changchun 130022, China.
authors.forename: Xiuxia
authors.initials: X
authors.lastname: He
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Hongda
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.|Department of Biological Engineering, School of Life Science and Technology, Changchun University of Science and Technology, Changchun 130022, China.
authors.forename: Junping
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Huimao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D060326:Chemistry Techniques, Synthetic; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D005707:Gallic Acid / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D007501:Iron / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000627:therapeutic use; D011205:Povidone / Q000737:chemistry; D065667:Renal Elimination; D000068936:Theranostic Nanomedicine; D023041:Xenograft Model Antitumor Assays
chemical_list: D005707:Gallic Acid; D007501:Iron; D011205:Povidone