title: Atrial natriuretic peptide modulates auditory brainstem response of rat.
abstract: CONCLUSIONS
  These findings suggest that Atrial natriuretic peptide (ANP) exhibits an inhibitory effect on auditory brainstem response (ABR) and is involved in the neuromodulation of the auditory nervous system.
  
  
  OBJECTIVE
  ANP may alter electrophysiological properties of the cochlea and play a role in auditory action.
  
  
  METHODS
  This study was undertaken to examine and clarify the role of ANP in the rat auditory system using ABR audiometry. The mean ABR thresholds and the latencies for wave II at the ABR threshold altered at given frequencies throughout the study.
  
  
  RESULTS
  Intra-arterial infusion of ANP (0.1 mg/kg, 4 mg/kg, and 8 mg/kg; bolus injection) resulted in a significant increase in ABR thresholds. A significant shift in the ABR wave II latency was observed at lower frequency (1 kHz and 2 kHz). There was a little change in latency at 20 kHz. Increased amount of ANP significantly altered the ABR in rats.
authors.affiliation: a 1 Department of Oto-Rhino-Laryngology, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital , Jeonju, Republic of Korea.
authors.forename: Yong Joo
authors.initials: YJ
authors.lastname: Yoon
authors.affiliation: a 1 Department of Oto-Rhino-Laryngology, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital , Jeonju, Republic of Korea.
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: b 2 Department of Audiology and Neurotology, Karolinska University Hospital , Stockholm, Sweden.
authors.forename: Sten
authors.initials: S
authors.lastname: Hellstrom
authors.affiliation: a 1 Department of Oto-Rhino-Laryngology, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital , Jeonju, Republic of Korea.
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D003051:Cochlea; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects* / Q000502:physiology; D007261:Infusions, Intra-Arterial; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009320:Atrial Natriuretic Factor
keywords: atrial natriuretic peptide; auditory brainstem response; neuromodulation