title: Prevalence of hepatitis B markers in Senegalese HIV-1-infected patients.
abstract: The study aimed to estimate the prevalence of Hepatitis B virus (HBV) infection and to describe the HBV virological profiles among Senegalese HIV-1-infected patients. We conducted a retrospective study between 2006 and 2010 among Senegalese HIV-1-infected patients from the antiretroviral therapy cohort. Samples were screened using Determine(®) HBsAg or MONOLISA(®) POC test. The HBsAg positivity status was confirmed by Architect(®) HBsAg. Detection of HBeAg, anti-HBe Ab, and HBV DNA load were done for the HBsAg-positive samples. Then, Anti-HBcAb was tested for the HBsAg-negative samples. Microsoft Excel was used for data collection and statistical analyses were performed using Epi info 3.5.1. Overall, 466 HIV-infected patients were enrolled including 271 women (58.4%), and 193 men (41.6%) with a median age of 39 years (19-74 years). The global prevalence of HIV/HBV coinfection (HBsAg positive) was 8.8% (41/466). For HBsAg positives samples, the prevalence of HBeAg and the anti-HBeAb were, respectively, 24.4 and 69.2% and the median of HBV DNA viral load, for 27 HBsAg-positive samples, was 3.75 log10 copies/ml. The virological profiles were the following: 7, 15, and 5 patients infected, respectively, by a replicative virus, an inactive virus and a probably mutant virus. For HBsAg-negative samples, 83 out of 109 were positive for anti-HBcAb. This study showed a significant decrease of the prevalence of HBV/HIV coinfection between 2004 and 2014 (P = 0.003), which highlighted the performance of the Senegalese HBV vaccine program. However, implementing a systematic quantification of HBV DNA viral load could improve the monitoring of HBV-infected patient.
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Gora
authors.initials: G
authors.lastname: Lô
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Amina
authors.initials: A
authors.lastname: Sow-Sall
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Halimatou
authors.initials: H
authors.lastname: Diop-Ndiaye
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Nokoa Chadia Ines Danty
authors.initials: NC
authors.lastname: Mandiouba
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Moussa
authors.initials: M
authors.lastname: Thiam
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Fatou
authors.initials: F
authors.lastname: Diop
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Ousseynou
authors.initials: O
authors.lastname: Ndiaye
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Sokhna Bousso
authors.initials: SB
authors.lastname: Gueye
authors.affiliation: University of Gaston Berger of Saint Louis, Saint Louis, Senegal.
authors.forename: Sidy Mouhamed
authors.initials: SM
authors.lastname: Seck
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Abou Abdallah Malick
authors.initials: AA
authors.lastname: Dioura
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Mbow
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Aïssatou
authors.initials: A
authors.lastname: Gaye-Diallo
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Souleymane
authors.initials: S
authors.lastname: Mboup
authors.affiliation: Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
authors.forename: Coumba
authors.initials: C
authors.lastname: Touré-Kâne
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D060085:Coinfection / Q000453:epidemiology*; D004279:DNA, Viral; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D015497:HIV-1; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012675:Senegal / Q000453:epidemiology; D019562:Viral Load; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
keywords: HIV-1; Senegal; hepatitis B virus; prevalence