title: The association between plasma thiol levels and left ventricular diastolic dysfunction in patient with hypertension.
abstract: The balance of oxidant and antioxidant status plays an important role in the left ventricular diastolic dysfunction (LVDD) in patients with hypertension (HT). Thiol is an important part of antioxidant system in the body. The aim of this study was to investigate the relationship between plasma thiol levels and LVDD in patients with HT. A total of 138 patients with newly diagnosed essential hypertensive and 20 age-gender matched subjects as control group enrolled in the study. After echocardiographic assessment, the hypertensive patients were divided into three groups: Group 1: without LVDD (n = 41); group 2: with LVDD grade 1 (n = 57); and group 3: with LVDD grade 2 (n = 40). Plasma thiol, lipid and glucose levels were measured in all subjects. Plasma thiol levels were significantly different between the groups (all of p < 0.05). While the lowest thiol level was in the group 3, the highest level was in the control group. The presence of LVDD was correlated with age, systolic and diastolic blood pressure, thiol levels, and history of coronary artery disease and hyperlipidemia (all of p < 0.05). Age and thiol were however independent predictors of LVDD in multivariate analyses (β = 0.318, p < 0.001, and β = - 0.314, p < 0.001, respectively). ROC-curve analysis revealed that thiol levels over 163 μmol/L predict LVDD in hypertensive patients with 75% sensitivity and 70% specificity (AUC = 0.783; 95% CI: 0.714-0.852). Plasma thiol is an independent predictor for the presence of LVDD. This suggests that thiol plays a role in the pathogenesis of diastolic function. Increased thiol levels may provide protection against the development of diastolic dysfunction.
authors.affiliation: a Department of Cardiology , Harran University Faculty of Medicine , Sanliurfa , Turkey.
authors.forename: Musluhittin Emre
authors.initials: ME
authors.lastname: Erkus
authors.affiliation: a Department of Cardiology , Harran University Faculty of Medicine , Sanliurfa , Turkey.
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Altiparmak
authors.affiliation: b Cardiology Clinic, Akcaabat Hackali Baba State Hospital , Trabzon , Turkey.
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Akyuz
authors.affiliation: a Department of Cardiology , Harran University Faculty of Medicine , Sanliurfa , Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Demirbag
authors.affiliation: a Department of Cardiology , Harran University Faculty of Medicine , Sanliurfa , Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sezen
authors.affiliation: a Department of Cardiology , Harran University Faculty of Medicine , Sanliurfa , Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Gunebakmaz
authors.affiliation: c Department of Biochemistry , Yildirim Beyazıt University Faculty of Medicine , Ankara , Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Neselioglu
authors.affiliation: c Department of Biochemistry , Yildirim Beyazıt University Faculty of Medicine , Ankara , Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D013438:Sulfhydryl Compounds / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood*
chemical_list: D015415:Biomarkers; D013438:Sulfhydryl Compounds
keywords: Antioxidants; diastolic heart failure; hypertension; redox; thiol