title: Music reduces pain and increases resting state fMRI BOLD signal amplitude in the left angular gyrus in fibromyalgia patients.
abstract: Music reduces pain in fibromyalgia (FM), a chronic pain disease, but the functional neural correlates of music-induced analgesia (MIA) are still largely unknown. We recruited FM patients (n = 22) who listened to their preferred relaxing music and an auditory control (pink noise) for 5 min without external noise from fMRI image acquisition. Resting state fMRI was then acquired before and after the music and control conditions. A significant increase in the amplitude of low frequency fluctuations of the BOLD signal was evident in the left angular gyrus (lAnG) after listening to music, which in turn, correlated to the analgesia reports. The post-hoc seed-based functional connectivity analysis of the lAnG showed found higher connectivity after listening to music with right dorsolateral prefrontal cortex (rdlPFC), the left caudate (lCau), and decreased connectivity with right anterior cingulate cortex (rACC), right supplementary motor area (rSMA), precuneus and right precentral gyrus (rPreG). Pain intensity (PI) analgesia was correlated (r = 0.61) to the connectivity of the lAnG with the rPreG. Our results show that MIA in FM is related to top-down regulation of the pain modulatory network by the default mode network (DMN).
authors.affiliation: Subdireccion de Investigaciones Clinicas, Instituto Nacional de Psiquiatria "Dr. Ramón de la Fuente Muñiz," Mexico City, Mexico ; Cátedras, National Council of Science and Technology (CONACYT) Mexico City, Mexico ; Department of Neurology, Faculty of Medicine and University Hospital "Dr. Jose E. Gonzalez" and Neuroscience Unit, Center for Research and Development in the Health Sciences, Universidad Autónoma de Nuevo León Monterrey, Mexico ; Music in the Brain, Center of Functionally Integrative Neuroscience, Aarhus University Aarhus, Denmark.
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Garza-Villarreal
authors.affiliation: Human Performance and Engineering, Kessler Foundation West Orange, NJ, USA ; Department of Biomedical Engineering, New Jersey Institute of Technology Newark, NJ, USA.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Music in the Brain, Center of Functionally Integrative Neuroscience, Aarhus University Aarhus, Denmark ; Royal Academy of Music Aarhus, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Vuust
authors.affiliation: Department of Behavioral and Cognitive Neurobiology, Institute of Neurobiology, Universidad Nacional Autonoma de Mexico Queretaro, Mexico.
authors.forename: Sarael
authors.initials: S
authors.lastname: Alcauter
authors.affiliation: Department of Psychology and Behavioral Sciences, University of Aarhus Aarhus, Denmark ; Danish Pain Research Center, Aarhus University Hospital Aarhus, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Vase
authors.affiliation: Department of Behavioral and Cognitive Neurobiology, Institute of Neurobiology, Universidad Nacional Autonoma de Mexico Queretaro, Mexico.
authors.forename: Erick H
authors.initials: EH
authors.lastname: Pasaye
authors.affiliation: Department of Neurology, Faculty of Medicine and University Hospital "Dr. Jose E. Gonzalez" and Neuroscience Unit, Center for Research and Development in the Health Sciences, Universidad Autónoma de Nuevo León Monterrey, Mexico.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cavazos-Rodriguez
authors.affiliation: Helsinki Collegium for Advanced Studies, University of Helsinki Helsinki, Finland.
authors.forename: Elvira
authors.initials: E
authors.lastname: Brattico
authors.affiliation: Department of Psychology and Behavioral Sciences, University of Aarhus Aarhus, Denmark.
authors.forename: Troels S
authors.initials: TS
authors.lastname: Jensen
authors.affiliation: Department of Behavioral and Cognitive Neurobiology, Institute of Neurobiology, Universidad Nacional Autonoma de Mexico Queretaro, Mexico.
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Barrios
keywords: BOLD signal; analgesia; angular gyrus; fALFF; fibromyalgia; music; pain; resting state fMRI