title: ortho-(Methyltosylaminoethynyl)benzyl glycosides as new glycosyl donors for latent-active glycosylation.
abstract: A new glycosylation protocol employing ortho-(methyltosylaminoethynyl)benzyl glycosides as glycosyl donors and TMSOTf as the catalyst is disclosed. These donors can be readily prepared from the corresponding 'latent' ortho-iodobenzyl glycosides via a Sonogashira coupling, thus providing a new approach for the 'latent-active' synthesis of glycans.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. byu@mail.sioc.ac.cn.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
authors.forename: Dacheng
authors.initials: D
authors.lastname: Shen
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Wang
authors.forename: You
authors.initials: Y
authors.lastname: Yang
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D002384:Catalysis; D006027:Glycosides / Q000737:chemistry*; D006031:Glycosylation; D008698:Mesylates / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D006027:Glycosides; D008698:Mesylates; D014297:Trimethylsilyl Compounds; C053353:trimethylsilyl trifluoromethanesulfonate