title: Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds.
abstract: A palladium-catalyzed tandem reaction is reported that involves chloropalladation/cyclization and dearomative cyclization to construct a tricyclic bridged [3.2.1] carbocyclic-skeleton and oxa- and aza-skeletons. In this domino process, a level of ring strain and other competitive reactions, i.e., protonolysis, β-hydride elimination, and chlorination of the C-Pd bond, were suppressed to the lowest level under mild reaction conditions.
authors.affiliation: †Tsinghua-Peking Center for Life Sciences, Handian Dist., Beijing 100084, P. R. China.|‡Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.affiliation: †Tsinghua-Peking Center for Life Sciences, Handian Dist., Beijing 100084, P. R. China.|‡Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China.
authors.forename: Nana
authors.initials: N
authors.lastname: Du
authors.affiliation: ‡Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Li
authors.affiliation: ‡Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China.
authors.forename: Litao
authors.initials: L
authors.lastname: Zheng
authors.affiliation: †Tsinghua-Peking Center for Life Sciences, Handian Dist., Beijing 100084, P. R. China.|‡Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006572:Heterocyclic Compounds, Bridged-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D006572:Heterocyclic Compounds, Bridged-Ring; D010165:Palladium; C008756:palladium chloride