title: Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E.
abstract: Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation. In this study performed on noniron deficient and well-trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28-days supplementation period with vitamins C (500 mg/day) and E (400 IU/day).
authors.affiliation: Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland.
authors.forename: Víctor
authors.initials: V
authors.lastname: Díaz
authors.affiliation: Department of Health and Human Performance, Technical University of Madrid, Madrid, Spain.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Peinado
authors.affiliation: Department of Health and Human Performance, Technical University of Madrid, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Barba-Moreno
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, Molecular Medicine Partnership Unit, University of Heidelberg, Heidelberg, Germany.
authors.forename: Sandro
authors.initials: S
authors.lastname: Altamura
authors.affiliation: Department of Health and Human Performance, Technical University of Madrid, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Butragueño
authors.affiliation: Department of Health and Human Performance, Technical University of Madrid, Madrid, Spain.
authors.forename: Marcela
authors.initials: M
authors.lastname: González-Gross
authors.affiliation: Institute of Nutritional and Food Sciences. Nutritional Physiology, Rheinische Friedrich Wilhelms Universität, Bonn, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Alteheld
authors.affiliation: Institute of Nutritional and Food Sciences. Nutritional Physiology, Rheinische Friedrich Wilhelms Universität, Bonn, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Stehle
authors.affiliation: Department of Physical Education, Complutense University of Madrid, Madrid, Spain.
authors.forename: Augusto G
authors.initials: AG
authors.lastname: Zapico
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, Molecular Medicine Partnership Unit, University of Heidelberg, Heidelberg, Germany.
authors.forename: Martina U
authors.initials: MU
authors.lastname: Muckenthaler
authors.affiliation: Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru maxg@access.uzh.ch.
authors.forename: Max
authors.initials: M
authors.lastname: Gassmann
keywords: Endurance; interleukin‐6; iron deficiency; performance; vitamins