title: Chakyunglupulins A and B, two novel 4,8,8-trimethylcyclooct-2-enone derivatives fromBarleria lupulina.
abstract: Two novel 4,8,8-trimethylcyclooct-2-enone derivatives, chakyunglupulins A and B, together with six known lignans were isolated from the aerial part ofBarleria lupulina. The structures of new compounds were established by extensive spectroscopic data and HR-MS, and their absolute configurations were determined by a combination of NOE experiment and application of the modified Mosher's method.
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 440-746, Republic of Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
authors.affiliation: Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Donald
authors.initials: D
authors.lastname: Senger
authors.affiliation: Natural Products and Experimental Therapeutics, Cancer Center, University of Hawaii, 701 Ilalo Street, Honolulu, Hawaii 96813, USA.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
keywords: 4; 8; 8-trimethylcyclooct-2-enone; Acanthaceae; Barleria lupulina; chakyunglupulins A and B; lignan