title: Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser.
abstract: Photothermal therapy (PTT) is widely regarded as a promising technology for cancer treatment. Gold nanorods (GNRs), as excellent PTT agent candidates, have shown high-performance photothermal conversion ability under laser irradiation, yet two major obstacles to their clinical application are the lack of selective accumulation in the target site following systemic administration and the greatly reduced photothermal conversion efficiency caused by self-aggregating in aqueous environment. Herein, we demonstrate that tLyp-1 peptide-functionalized, indocyanine green (ICG)-containing mesoporous silica-coated GNRs (I-TMSG) possessed dual-function as tumor cells-targeting near-infrared (NIR) fluorescent probe and PTT agents. The construction of the nanostructure began with synthesis of GNRs by seed-mediated growth method, followed by the coating of mesoporous silica, the chemical conjugation of PEG and tLyp-1 peptide, and the enclosure of ICG as an NIR imaging agent in the mesoporous. The as-prepared nanoparticles could shield the GNRs against their self-aggregation, improve the stability of ICG, and exhibit negligible dark cytotoxicity. More importantly, such a theranostic nanocomposite could realize the combination of GNRs-based photothermal ablation under NIR illumination, ICG-mediated fluorescent imaging, and tLyp-1-enabled more easy endocytosis into breast cancer cells. All in all, I-TMSG nanoparticles, in our opinion, possessed the strong potential to realize the effective diagnosis and PTT treatment of human mammary cancer.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China ; Department of Pharmacy, Bengbu Medical College, Bengbu, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Guannan
authors.initials: G
authors.lastname: Guan
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Hu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Mingxi
authors.initials: M
authors.lastname: Qiao
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Pharmacy, Bengbu Medical College, Bengbu, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Heyun
authors.initials: H
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D007834:Lasers; D053761:Nanocomposites / Q000737:chemistry / Q000633:toxicity; D043942:Nanotubes / Q000737:chemistry / Q000633:toxicity; D010789:Phototherapy / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry / Q000633:toxicity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D006046:Gold; D012822:Silicon Dioxide
keywords: anti-mammary cancer; gold nanorods; indocyanine green; mesoporous silica; photothermal therapy; theranostic nanoagents