title: [A rare cause of eosinophilic asthma: Hyper-IgG4 syndrome (IgG4-related sclerosing disease)].
abstract: BACKGROUND
  The hyper-IgG4 syndrome is an emerging disease with various thoracic manifestations: eosinophilic asthma, adenomegalies or mediastinal fibrosis, asthma, infiltrative pneumonia, nodules or pseudo-tumors with bronchial and pleural localizations.
  
  
  METHODS
  We report the case of a 38-year-old woman who was admitted for acute exacerbation of eosinophilic asthma with high total IgE levels. A medical history of idiopathic acute pancreatitis, associated with sclerosing cholangitis and renal failure, suggested a diagnosis of hyper-IgG4 syndrome in this woman with late-onset severe and non-atopic asthma. A previous hepatic histology and a reinterpretation of renal tomodensitometry have confirmed this hypothesis.
  
  
  CONCLUSIONS
  The hyper-IgG4 syndrome is responsible of different clinico-radiological patterns that should be evoked because of the pejorative evolution of this steroid sensitive disease.
authors.affiliation: Service de pneumologie et oncologie thoracique, centre hospitalier Eure-Seine, rue Léon-Schwartzenberg, 27015 Évreux, France. Electronic address: anas.mehdaoui@chi-eureseine.fr.
authors.forename: A
authors.initials: A
authors.lastname: Mehdaoui
authors.affiliation: Service de pneumologie et oncologie thoracique, centre hospitalier Eure-Seine, rue Léon-Schwartzenberg, 27015 Évreux, France.
authors.forename: M
authors.initials: M
authors.lastname: Manoila
authors.affiliation: Service de pneumologie et oncologie thoracique, centre hospitalier Eure-Seine, rue Léon-Schwartzenberg, 27015 Évreux, France.
authors.forename: M
authors.initials: M
authors.lastname: Jaafar
authors.affiliation: Service de pneumologie et oncologie thoracique, centre hospitalier Eure-Seine, rue Léon-Schwartzenberg, 27015 Évreux, France.
authors.forename: H
authors.initials: H
authors.lastname: Mahmoud
authors.affiliation: Service de pneumologie et oncologie thoracique, centre hospitalier Eure-Seine, rue Léon-Schwartzenberg, 27015 Évreux, France.
authors.forename: E
authors.initials: E
authors.lastname: Devin
mesh_terms: D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000209:etiology*; D001327:Autoimmune Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D015209:Cholangitis, Sclerosing / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D008107:Liver Diseases / Q000150:complications / Q000276:immunology; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D011657:Pulmonary Eosinophilia / Q000175:diagnosis / Q000209:etiology*; D013577:Syndrome
chemical_list: D007074:Immunoglobulin G
keywords: Asthme éosinophilique; Eosinophilic asthma; Hyper-IgG4 syndrome; Lung; Poumon; Syndrome hyper-IgG4; Traitement; Treatment