title: Single-injection vaccines: Progress, challenges, and opportunities.
abstract: Currently, vaccination is the most efficient and cost-effective medical treatment for infectious diseases; however, each year 10 million infants remain underimmunized due to current vaccination schedules that require multiple doses to be administered across months or years. These dosing regimens are especially challenging in the developing world where limited healthcare access poses a major logistical barrier to immunization. Over the past four decades, researchers have attempted to overcome this issue by developing single-administration vaccines based on controlled-release antigen delivery systems. These systems can be administered once, but release antigen over an extended period of time to elicit both primary and secondary immune responses resulting in antigen-specific immunological memory. Unfortunately, unlike controlled release systems for drugs, single-administration vaccines have yet to be commercialized due to poor antigen stability and difficulty in obtaining unconventional release kinetics. This review discusses the current state of single-administration vaccination, challenges delaying the development of these vaccines, and potential strategies for overcoming these challenges.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: McHugh
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
authors.forename: Rohiverth
authors.initials: R
authors.lastname: Guarecuco
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States. Electronic address: jaklenec@mit.edu.
authors.forename: Ana
authors.initials: A
authors.lastname: Jaklenec
mesh_terms: D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D004334:Drug Administration Schedule; D016503:Drug Delivery Systems; D006801:Humans; D007267:Injections; D014611:Vaccination / Q000379:methods; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D000941:Antigens; D003692:Delayed-Action Preparations; D014612:Vaccines
keywords: Antigen stability; Global health; Microparticles; Protein encapsulation; Release kinetics; Single-administration vaccines