title: Total synthesis of the natural product EBC-329.
abstract: The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory (CSIR-NCL), Pune-411008, India. vh.jadhav@ncl.res.in.
authors.forename: Raju S
authors.initials: RS
authors.lastname: Thombal
authors.forename: Vrushali H
authors.initials: VH
authors.lastname: Jadhav
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D004224:Diterpenes; C000607931:EBC-329