title: Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience.
abstract: Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems. We established an acute and chronic PD model in nonuremic and uremic rats. We observed that kinetics of PD in rats change as the animals are aging, and this effect is due not only to an increasing peritoneal surface area, but also to changes in the permeability of the peritoneum. Changes of the peritoneal permeability seen during chronic PD in rats are comparable to results obtained in humans treated with PD. Effluent dialysate can be drained repeatedly to measure concentration of various bioactive molecules and to correlate the results with the peritoneal permeability. Additionally we can study in in vitro conditions properties of the effluent dialysate on cultured peritoneal mesothelial cells or fibroblasts. We can evaluate acute and chronic effect of various additives to the dialysis fluid on function and permeability of the peritoneum. Results from such study are even more relevant to the clinical scenario when experiments are performed in uremic rats. Our experimental animal PD model not only helps to understand the pathophysiology of PD but also can be used for testing biocompatibility of new PD fluids.
authors.affiliation: Department of Nephrology, Transplantology, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland ; Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pawlaczyk
authors.affiliation: Department of Pathophysiology, Poznan University of Medical Sciences, Ulica Rokietnicka 8, 60-806 Poznan, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Baum
authors.affiliation: Department of Nephrology, Transplantology, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Schwermer
authors.affiliation: Department of Nephrology, Transplantology, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Hoppe
authors.affiliation: Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindholm
authors.affiliation: Department of Pathophysiology, Poznan University of Medical Sciences, Ulica Rokietnicka 8, 60-806 Poznan, Poland ; Higher Vocational State School, Kalisz, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Breborowicz
mesh_terms: D000818:Animals; D001692:Biological Transport; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010538:Peritonitis / Q000209:etiology; D014511:Uremia / Q000209:etiology