title: Effect of GSTM1 and GSTT1 Polymorphisms on Genetic Damage in Humans Populations Exposed to Radiation From Mobile Towers.
abstract: All over the world, people have been debating about associated health risks due to radiation from mobile phones and mobile towers. The carcinogenicity of this nonionizing radiation has been the greatest health concern associated with mobile towers exposure until recently. The objective of our study was to evaluate the genetic damage caused by radiation from mobile towers and to find an association between genetic polymorphism of GSTM1 and GSTT1 genes and DNA damage. In our study, 116 persons exposed to radiation from mobile towers and 106 control subjects were genotyped for polymorphisms in the GSTM1 and GSTT1 genes by multiplex polymerase chain reaction method. DNA damage in peripheral blood lymphocytes was determined using alkaline comet assay in terms of tail moment (TM) value and micronucleus assay in buccal cells (BMN). There was a significant increase in BMN frequency and TM value in exposed subjects (3.65 ± 2.44 and 6.63 ± 2.32) compared with control subjects (1.23 ± 0.97 and 0.26 ± 0.27). However, there was no association of GSTM1 and GSTT1 polymorphisms with the level of DNA damage in both exposed and control groups.
authors.affiliation: Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, 136119, India.|Department of Biochemistry, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
authors.forename: Sachin
authors.initials: S
authors.lastname: Gulati
authors.affiliation: Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, 136119, India. ayadav@kuk.ac.in.
authors.forename: Anita
authors.identifier: http://orcid.org/0000-0002-4586-2064
authors.initials: A
authors.lastname: Yadav
authors.affiliation: Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
authors.lastname: Kanupriya
authors.affiliation: Department of Microbiology, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
authors.forename: Neeraj K
authors.initials: NK
authors.lastname: Aggarwal
authors.affiliation: Department of Forensic Medicine, PGIMER, Chandigarh, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Department of Biochemistry, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Gupta
mesh_terms: D004249:DNA Damage; D004574:Electromagnetic Fields; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes; D011110:Polymorphism, Genetic; D000069079:Radiation Exposure; D011834:Radiation Monitoring
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1