title: Change in intrarenal Ghrelin expression in immune complex-mediated glomerular disease in dogs.
abstract: Ghrelin is a peptide hormone that is mainly produced by the stomach. The kidney is a major source of local ghrelin, and maintaining body fluid balance is considered a critical role of renal ghrelin. However, there are no reports on renal ghrelin in small animal medicine. The present study investigated the intrarenal localization of and change in ghrelin expression in dogs with immune complex-mediated glomerulonephritis (ICGN). Ghrelin immunoreactivity (IR) was observed in the distal tubules of normal kidneys. Ghrelin IR was weak in ICGN kidneys, and the quantitative ghrelin IR score was significantly lower in ICGN kidneys than in normal kidneys. In cases of ICGN, plasma creatinine concentrations showed a positive correlation with the ghrelin IR score.
authors.affiliation: Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yabuki
authors.forename: Keijiro
authors.initials: K
authors.lastname: Mizukami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tokunaga
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D054439:Ghrelin / Q000378:metabolism*; D005921:Glomerulonephritis / Q000378:metabolism / Q000662:veterinary*; D007105:Immune Complex Diseases / Q000378:metabolism / Q000662:veterinary*; D007668:Kidney / Q000378:metabolism; D007686:Kidney Tubules, Distal / Q000378:metabolism; D008297:Male
chemical_list: D054439:Ghrelin; D003404:Creatinine