title: The influence of intravenous ondansetron on maternal blood haemodynamics after spinal anaesthesia for caesarean section: a double-blind, placebo-controlled study.
abstract: OBJECTIVE
  verification of a hypothesis assuming that 5-HT3 receptor blockade by intravenous administration of ondansetron reduces the incidence of hypotension and bradycardia in patients undergoing spinal anaesthesia for Caesarean section.
  
  
  METHODS
  The study design was approved by the Bioethics Committee and included 72 patients undergoing elective Caesarean section, randomly assigned to ondansetron group (group 0) or placebo group (group P). Finally group 0 encompassed 35 patients administered ondansetron 8 mg i.v. dissolved in 10 ml 0.9% NaCl whereas group P consisted of 34 patients receiving 0.9% NaCl 10 mg. Systolic and diastolic pressures were measured every 2 minutes since the onset of anaesthesia. Heart rate (HR) was monitored continuously The criterion of hypotension requiring ephedrine was a decrease in systolic pressure by 20% compared to its baseline value or a decrease in systolic pressure below 90 mm Hg. The criterion of bradycardia was a decrease in HR below 60/min.
  
  
  RESULTS
  Hypotension was observed in 14 group 0 patients (39%) and in 15 group P patients (44%); the difference was not statistically significant. Bradycardia was noted in 1 group 0 patient (3%) and in 2 group P patients (6%); the difference was not statistically significant.
  
  
  CONCLUSIONS
  A hypothesis assuming a reduction in pressure following subarachnoid anaesthesia for Caesarean section after the administration of 8 mg of ondansetron was not confirmed.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Marciniak
authors.forename: Radosław
authors.initials: R
authors.lastname: Owczuk
authors.forename: Maria
authors.initials: M
authors.lastname: Wujtewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Preis
authors.forename: K
authors.initials: K
authors.lastname: Majdyło
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002585:Cesarean Section / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000517:prevention & control*; D007231:Infant, Newborn; D007275:Injections, Intravenous; D017294:Ondansetron / Q000008:administration & dosage*; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D017294:Ondansetron