title: Maternal Asthma, Preterm Birth, and Risk of Bronchopulmonary Dysplasia.
abstract: OBJECTIVE
  To study the relationship between maternal asthma and the development of bronchopulmonary dysplasia (BPD).
  
  
  METHODS
  Using a large population-based California cohort, we investigated associations between maternal asthma and preterm birth subtype, as well as maternal asthma and BPD. We used data from 2007-2010 maternal delivery discharge records of 2 009 511 pregnancies and International Classification of Diseases, Ninth Revision codes. Preterm birth was defined as <37 weeks gestational age (GA), with subgroups of <28 weeks, 28-32 weeks, and 33-37 weeks GA, as well as preterm subtype, defined as spontaneous, medically indicated, or unknown. Linkage between the 2 California-wide datasets yielded 21 944 singleton preterm infants linked to their mother's records, allowing estimation of the risk of BPD in mothers with asthma and those without asthma.
  
  
  RESULTS
  Maternal asthma was associated with increased odds (OR, 1.42; 95% CI, 1.38-1.46) of preterm birth at <37 weeks GA, with the greatest risk for 28-32 GA (aOR, 1.60; 95% CI, 1.47-1.74). Among 21 944 preterm infants, we did not observe an elevated risk for BPD in infants born to mothers with asthma (aOR, 1.03; 95% CI, 0.9-1.2). Stratification by maternal treatment with antenatal steroids revealed increased odds of BPD in infants whose mothers had asthma but did not receive antenatal steroids (aOR, 1.54; 95% CI, 1.15-2.06), but not in infants whose mothers had asthma and were treated with antenatal steroids (aOR, 0.85; 95% CI, 0.67-1.07).
  
  
  CONCLUSIONS
  Asthma in mothers who did not receive antenatal steroid treatment is associated with an increased risk of BPD in their preterm infants.
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA. Electronic address: sgage@stanford.edu.
authors.forename: Susan
authors.initials: S
authors.lastname: Gage
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA.
authors.forename: Peiyi
authors.initials: P
authors.lastname: Kan
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA; California Perinatal Quality Care Collaborative, Stanford, CA.
authors.forename: Henry C
authors.initials: HC
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA; California Perinatal Quality Care Collaborative, Stanford, CA; California Office of Statewide Health Planning and Development, Sacramento, CA.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Gould
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA.
authors.forename: David K
authors.initials: DK
authors.lastname: Stevenson
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Shaw
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA.
authors.forename: Hugh M
authors.initials: HM
authors.lastname: O'Brodovich
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000453:epidemiology* / Q000503:physiopathology; D001724:Birth Weight; D015992:Body Mass Index; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology*; D002140:California; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008423:Maternal Age; D018811:Maternal Exposure; D008875:Middle Aged; D009035:Mothers; D016017:Odds Ratio; D010351:Patient Discharge; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D047928:Premature Birth / Q000453:epidemiology*; D012307:Risk Factors; D013256:Steroids / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D013256:Steroids