title: Predictors of high on-clopidogrel platelet reactivity in patients with acute coronary syndrome.
abstract: High on-clopidogrel platelet reactivity (HPR) is a predictor of ischemic events after percutaneous coronary intervention. We conducted a prospective cohort study to identify variables related to HPR in acute coronary syndrome patients who are at high thrombotic risk. We enrolled 463 patients undergoing urgent coronary angiography. Platelet reactivity was measured 12-36 hours after 600 mg clopidogrel loading with multiple electrode aggregometry (Multiplate® analyzer, Roche, Basel, Switzerland, 6.4 µM ADP). HPR was defined by the consensus cut-off area under the curve >46 U. The rate of HPR was 16.0%. We analyzed simple clinical and laboratory parameters with backward multivariate logistic regression and identified the following predictors of HPR: platelet count (per G/L, OR: 1.0073, 95% CI: 1.0035-1.0112, p = 0.0002), CRP level (per mg/L, OR: 1.0077, 95% CI: 1.0016-1.01372, p = 0.01), and active smoking (OR: 0.51, 95% CI: 0.29-0.89, p = 0.02). We developed and internally validated a risk prediction model demonstrating moderate discriminative capacity (area-under-the-receiver operating characteristic curve = 0.67). In conclusion, we found a relatively low rate of high on-clopidogrel platelet reactivity (16.0%) even in an acute patient cohort. HPR measured by Multiplate was associated with high platelet count and CRP level on admission and was inversely related to active smoking. The model with rapidly available simple parameters might help to identify individuals at risk for HPR in the acute setting.
authors.affiliation: a School of Ph.D. Studies, Semmelweis University , Budapest , Hungary and.
authors.forename: Sarolta
authors.initials: S
authors.lastname: Lee
authors.affiliation: b Department of Cardiology , Medical Centre, Hungarian Defence Forces , Budapest , Hungary.
authors.forename: Istvan
authors.initials: I
authors.lastname: Hizoh
authors.affiliation: b Department of Cardiology , Medical Centre, Hungarian Defence Forces , Budapest , Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Kovacs
authors.affiliation: b Department of Cardiology , Medical Centre, Hungarian Defence Forces , Budapest , Hungary.
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Horvath
authors.affiliation: b Department of Cardiology , Medical Centre, Hungarian Defence Forces , Budapest , Hungary.
authors.forename: Nora
authors.initials: N
authors.lastname: Kiss
authors.affiliation: b Department of Cardiology , Medical Centre, Hungarian Defence Forces , Budapest , Hungary.
authors.forename: Emese
authors.initials: E
authors.lastname: Toth-Zsamboki
authors.affiliation: b Department of Cardiology , Medical Centre, Hungarian Defence Forces , Budapest , Hungary.
authors.forename: Robert Gabor
authors.initials: RG
authors.lastname: Kiss
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D019540:Area Under Curve; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D000077144:Clopidogrel; D017023:Coronary Angiography; D016015:Logistic Models; D062645:Percutaneous Coronary Intervention; D015539:Platelet Activation / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010976:Platelet Count; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000503:physiopathology; D013927:Thrombosis / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors; D002097:C-Reactive Protein; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: Acute coronary syndrome; clopidogrel; inhibitors; multiple electrode aggregometry; percutaneous coronary intervention; platelets; risk factors; thrombosis