title: Association of Serum Uric Acid Level With Blood Pressure Variability in Newly Diagnosed Essential Hypertension.
abstract: Serum uric acid (UA) is independently associated with hypertension and blood pressure (BP) variability (BPV) is associated with cardiovascular events and mortality in hypertensive patients. The aim of the present study was to assess the association of serum UA with BPV in 300 untreated essential hypertension patients (mean age 57.3±13.6 years). BPV was quantified as the standard deviation (SD) of the 24-hour, daytime, and nighttime mean values obtained by using ambulatory BP monitoring. In correlation analysis, log UA values were found to be positively correlated with 24-hour systolic BPV and nighttime systolic and diastolic BPV (Pearson coefficients of 0.246, 0.280, and 0.353, respectively; P<.001 for all). In multivariate analysis, log UA had an independent association with 24-hour systolic BPV and nighttime systolic and diastolic BPV. This study show for the first time that increased serum UA is independently associated with BPV in untreated essential hypertension patients.
authors.affiliation: Cardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Kumral
authors.initials: K
authors.lastname: Çağlı
authors.affiliation: Cardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Turak
authors.affiliation: Cardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Uğur
authors.initials: U
authors.lastname: Canpolat
authors.affiliation: Cardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Fırat
authors.initials: F
authors.lastname: Özcan
authors.affiliation: Cardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Tok
authors.affiliation: Cardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Mendi
authors.affiliation: Cardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Öksüz
authors.affiliation: Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
authors.forename: Dimitrie
authors.initials: D
authors.lastname: Siriopol
authors.affiliation: Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Veisa
authors.affiliation: Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
authors.affiliation: Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid