title: Addison's disease in a patient with hypothyroidism: autoimmune polyglandular syndrome type 2.
abstract: A 57-year-old Caucasian woman with known autoimmune hypothyroidism diagnosed in 2006 presented to hospital with flu-like symptoms and circulatory collapse. She reported weight loss and gradual increase in her skin pigmentation over a 1-year period. Aggressive fluid resuscitation was instituted. Hormonal tests showed primary adrenal insufficiency. Appropriate steroid replacement was started with rapid clinical response. Subsequent antibody tests confirmed the diagnosis of autoimmune polyglandular type 2 (Schmidt's) syndrome. The adrenal crisis had been precipitated by influenza virus type B infection.
authors.affiliation: University of Auckland, Auckland, New Zealand.
authors.forename: Anna
authors.initials: A
authors.lastname: Bain
authors.affiliation: Tauranga Hospital, Tauranga, Bay of Plenty, New Zealand.
authors.forename: Munro
authors.initials: M
authors.lastname: Stewart
authors.affiliation: Tauranga Hospital, Tauranga, Bay of Plenty, New Zealand.
authors.forename: Peter
authors.initials: P
authors.lastname: Mwamure
authors.affiliation: Tauranga Hospital, Tauranga, Bay of Plenty, New Zealand.
authors.forename: Kingsley
authors.initials: K
authors.lastname: Nirmalaraj
mesh_terms: D000224:Addison Disease / Q000209:etiology*; D000311:Adrenal Glands; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005440:Fluid Therapy; D050031:Hashimoto Disease / Q000209:etiology*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D007251:Influenza, Human / Q000150:complications / Q000821:virology; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D013256:Steroids / Q000627:therapeutic use; D013577:Syndrome; D013961:Thyroid Gland; D013967:Thyroiditis, Autoimmune / Q000209:etiology*
chemical_list: D001323:Autoantibodies; D013256:Steroids