title: Solitary Neurofibroma with Malignant Transformation: Case Report and Review Of Literature.
abstract: Solitary neurofibromas are rare tumors associated mainly with neurofibromatosis and widely described in the literature as benign. We report a case of a 55-year-old female with no history of neurofibromatosis who presented with a slow-growing, painless lump on her torso. Pathologic evaluation of the lesion after excisional biopsy revealed high mitotic activity and increased cellularity within the lesion as well as positive S-100 stain. She was diagnosed with solitary subcutaneous neurofibroma with features of malignant peripheral nerve sheath tumor transformation. To our knowledge, no other case of a solitary neurofibroma that transformed into a malignant tumor in this location was described in the literature.
authors.forename: Emilia M
authors.initials: EM
authors.lastname: Krol
authors.forename: Hani
authors.initials: H
authors.lastname: El-Fanek
authors.forename: John
authors.initials: J
authors.lastname: Borruso
mesh_terms: D000008:Abdominal Neoplasms / Q000209:etiology / Q000473:pathology*; D034861:Abdominal Wall / Q000473:pathology*; D001706:Biopsy; D005260:Female; D006801:Humans; D008875:Middle Aged; D008938:Mitosis; D018317:Nerve Sheath Neoplasms / Q000209:etiology / Q000473:pathology*; D009455:Neurofibroma / Q000150:complications* / Q000473:pathology