title: Community-acquired Legionnaires' disease in a renal transplant recipient with unclear incubation period: the importance of molecular typing.
abstract: Transplant recipients are at risk of developing Legionnaires' disease (LD) because of impaired cellular immunity. Here, we describe a renal transplant recipient who developed LD at least 10 days after hospital admission and transplantation. The hospital water network was initially suspected, but further testing determined that the probable source was the patient's domestic water supply. Our report also suggests that the patient's immunosuppressed state may have switched potential colonization to pneumonia.
authors.affiliation: Hospices Civils de Lyon, Unité d'Hygiène et d'Epidémiologie, Groupement Hospitalier Edouard Herriot, Lyon, France.|Hospices Civils de Lyon, Centre National de Reference des Legionelles, Centre de Biologie Est Hospices Civils de Lyon, Bron, France.|CIRI, International Center for Infectiology Research, Legionella Pathogenesis Team, Université de Lyon, Lyon, France.|Inserm, U1111, Lyon, France.|Ecole Normale Supérieure de Lyon, Lyon, France.|Centre International de Recherche en Infectiologie, Université de Lyon 1, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Cassier
authors.affiliation: Hospices Civils de Lyon, Unité d'Hygiène et d'Epidémiologie, Groupement Hospitalier Edouard Herriot, Lyon, France.|Laboratoire d'épidémiologie et de santé publique, CNRS, UMR5308, Université de Lyon 1, Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Bénet
authors.affiliation: Hospices Civils de Lyon, Unité d'Hygiène et d'Epidémiologie, Groupement Hospitalier Edouard Herriot, Lyon, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Nicolle
authors.affiliation: Hospices Civils de Lyon, Transplantation, Néphrologie et Immunologie Clinique, Groupement Hospitalier Edouard Herriot, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Brunet
authors.affiliation: Hospices Civils de Lyon, Transplantation, Néphrologie et Immunologie Clinique, Groupement Hospitalier Edouard Herriot, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Buron
authors.affiliation: Hospices Civils de Lyon, Transplantation, Néphrologie et Immunologie Clinique, Groupement Hospitalier Edouard Herriot, Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Morelon
authors.affiliation: Hospices Civils de Lyon, Centre National de Reference des Legionelles, Centre de Biologie Est Hospices Civils de Lyon, Bron, France.
authors.forename: L
authors.initials: L
authors.lastname: Béraud
authors.affiliation: Hospices Civils de Lyon, Centre National de Reference des Legionelles, Centre de Biologie Est Hospices Civils de Lyon, Bron, France.|CIRI, International Center for Infectiology Research, Legionella Pathogenesis Team, Université de Lyon, Lyon, France.|Inserm, U1111, Lyon, France.|Ecole Normale Supérieure de Lyon, Lyon, France.|Centre International de Recherche en Infectiologie, Université de Lyon 1, Lyon, France.
authors.forename: G
authors.initials: G
authors.lastname: Descours
authors.affiliation: Hospices Civils de Lyon, Centre National de Reference des Legionelles, Centre de Biologie Est Hospices Civils de Lyon, Bron, France.|CIRI, International Center for Infectiology Research, Legionella Pathogenesis Team, Université de Lyon, Lyon, France.|Inserm, U1111, Lyon, France.|Ecole Normale Supérieure de Lyon, Lyon, France.|Centre International de Recherche en Infectiologie, Université de Lyon 1, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Jarraud
authors.affiliation: Hospices Civils de Lyon, Unité d'Hygiène et d'Epidémiologie, Groupement Hospitalier Edouard Herriot, Lyon, France.|Hospices Civils de Lyon, Centre National de Reference des Legionelles, Centre de Biologie Est Hospices Civils de Lyon, Bron, France.|CIRI, International Center for Infectiology Research, Legionella Pathogenesis Team, Université de Lyon, Lyon, France.|Inserm, U1111, Lyon, France.|Ecole Normale Supérieure de Lyon, Lyon, France.|Centre International de Recherche en Infectiologie, Université de Lyon 1, Lyon, France.|Laboratoire d'épidémiologie et de santé publique, CNRS, UMR5308, Université de Lyon 1, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Vanhems
mesh_terms: D017714:Community-Acquired Infections / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D007877:Legionnaires' Disease / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D058889:Molecular Typing; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D014871:Water Microbiology
keywords: Legionella; Legionnaires' disease; incubation period; molecular typing; oropharyngeal colonization; renal transplant