title: Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma.
abstract: BACKGROUND
  Pulmonary spindle cell carcinoma (SpCC) is a rare subtype of non-small-cell lung cancer (NSCLC) and, in general, is chemoresistance.
  
  
  METHODS
  A sixty-five year-old male patient with metastatic pulmonary SpCC was initially treated with cisplatin and docetaxel, but his disease progressed. Then, he received a combination chemotherapy with carboplatin and nab-PTX followed by maintenanced chemotherapy with nab-PTX. Fluorodeoxyglucose (FDG) positron-emission CT revealed a substantial decrease of FDG accumulation in the primary tumor, and the response continued for more than 7 months.
  
  
  CONCLUSIONS
  Preclinical models suggested that nab-PTX may reach the tumor microenvironment more efficiently than solvent-based paclitaxel (sb-PTX) and be preferentially taken up by cancer cells. Considering that there is no effective treatment for patients with pulmonary SpCC, nab-PTX may merit further investigation in patients with pulmonary SpCC.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuji
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Young Hak
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ozasa
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sakamori
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nagai
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Ajimizu
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Yagi
authors.affiliation: Department of Diagnostic Pathology, Kyoto University Hospital, Japan.
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Furukawa
authors.affiliation: Department of Diagnostic Pathology, Kyoto University Hospital, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Haga
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
keywords: Nab-PTX; Pulmonary sarcomatoid carcinoma; Spindle cell carcinoma