title: Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots.
abstract: Mechanical force-based stimulus provides a simple and easily accessible manner for spatiotemporally controlled drug delivery. Here we describe a wearable, tensile strain-triggered drug delivery device consisting of a stretchable elastomer and microgel depots containing drug loaded nanoparticles. By applying a tensile strain to the elastomer film, the release of drug from the microdepot is promoted due to the enlarged surface area for diffusion and Poisson's ratio-induced compression on the microdepot. Correspondingly, both sustained drug release by daily body motions and pulsatile release by intentional administration can be conveniently achieved. Our work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments. Moreover, polymeric microneedles were further integrated with the stretch-responsive device for transcutaneous delivery of insulin and regulation of blood glucose levels of chemically induced type 1 diabetic mice.
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
authors.forename: Jin
authors.initials: J
authors.lastname: Di
authors.affiliation: Department of Mechanical and Aerospace Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Yao
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
authors.forename: Yanqi
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Mechanical and Aerospace Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Yu
authors.affiliation: Fiber and Polymer Science Program, Textile Engineering, Chemistry, and Science Department, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Tushar K
authors.initials: TK
authors.lastname: Ghosh
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Department of Mechanical and Aerospace Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.|Department of Medicine, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020724:Elastomers / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology
chemical_list: D020724:Elastomers; D011108:Polymers
keywords: drug delivery; microdepots; nanoparticles; stimuli-responsive; wearable devices