title: Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.
abstract: This study aims to investigate the effect of the partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility through a comprehensive literature search. All case-control studies related to partial DAZ1/2 and DAZ3/4 deletions and male infertility risk were included in our study. Odd ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and its precision, respectively. Eleven partial DAZ1/2 deletion and nine partial DAZ3/4 deletion studies were included. Partial DAZ1/2 deletion was significantly associated with male infertility risk in the overall analysis (ORs=2.58, 95%CI: 1.60-4.18, I(2)=62.1%). Moreover, in the subgroup analysis stratified by ethnicity, partial DAZ1/2 deletion was significantly associated with male infertility risk in the East Asian populations under the random effect model (ORs=2.96, 95%CI: 1.87-4.71, I(2)=51.3%). Meanwhile, the analysis suggested that partial DAZ3/4 deletion was not associated with male infertility risk in East-Asian ethnicity (ORs=1.02, 95%CI: 0.54-1.92, I(2)=71.3%), but not in Non-East Asian under the random effect model (ORs=3.56, 95%CI: 1.13-11.23, I(2)=0.0%,). More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs=2.63, 95%CI: 1.19-5.81, I(2)=64.7%) and oligozoospermia (ORs=2.53, 95%CI: 1.40-4.57, I(2)=51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs=0.71, 95%CI: 0.23-2.22, I(2)=71.7%,) and oligozoospermia (ORs=1.21, 95%CI: 0.65-2.24, I(2)=55.5%). In our meta-analysis, partial DAZ1/2 deletion is a risk factor for male infertility and different ethnicities have different influences, whereas partial DAZ3/4 deletion has no effect on fertility but partial DAZ3/4 deletion might have an impact on Non-East Asian male.
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Yuening
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Muyan
authors.initials: M
authors.lastname: Li
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Feifan
authors.initials: F
authors.lastname: Xiao
authors.affiliation: Reproduction Medical Center, Affiliated Hospital of Guilin Medical College Guilin, Guangxi, China.
authors.forename: Ruobing
authors.initials: R
authors.lastname: Teng
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Chengdong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Lan
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Kailong
authors.initials: K
authors.lastname: Gu
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jiatong
authors.initials: J
authors.lastname: Li
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Li
authors.affiliation: Reproductive Medical Research Center, Department of Guangxi Medical University Affiliated Hospital, Nanning, Guangxi, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Urology Medical Research Center, Department of Guangxi Medical University Affiliated Hospital, Nanning, Guangxi, China.
authors.forename: Siping
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.affiliation: Department of Forensic Toxicology, Institute of Forensic Sciences, Ministry of Justice, Shanghai Key Laboratory of Forensic Medicine, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Guangdong Provincial Hospital of Chinese People's Armed Police Force, Guangzhou, Guangdong, China.
authors.forename: Peifen
authors.initials: P
authors.lastname: Guo
authors.affiliation: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China. Electronic address: cncsyxl@126.com.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D000075364:Deleted in Azoospermia 1 Protein; D005202:Asia, Eastern; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000208:ethnology / Q000235:genetics*; D008297:Male; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: C095668:DAZ1 protein, human; C459440:DAZ2 protein, human; C543054:DAZ3 protein, human; C543055:DAZ4 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D016601:RNA-Binding Proteins
keywords: AZFc; Meta-analysis; Spermatogenic