title: The Association of Race With Childhood Uveitis.
abstract: OBJECTIVE
  To identify risk factors for a severe uveitis course among children with noninfectious uveitis.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  This was a retrospective analysis of a prospectively collected database. Records of 94 children with uveitis were reviewed at enrollment and every 3-6 months (2011-2015). Severe uveitis was defined as a history of ocular complications or a visual acuity (VA) of ≤20/200. Children were compared by disease, VA, complications, and race. Regression models were used to model risk factors for severe disease. When examining race, we focused on non-Hispanic African-American and non-Hispanic white children only.
  
  
  RESULTS
  Of 85 children with uveitis and complete ocular examinations, 27 (32%) had a history of a VA of ≤20/200. A subanalysis of non-Hispanic African-American and white children showed an increased prevalence of VA ≤20/200 in non-Hispanic African-Americans (18/25; 72% vs 4/43; 9%). Non-Hispanic African-Americans were more likely to be diagnosed at an older age (P = .030) and to have intermediate uveitis (P = .026), bilateral disease (P = .032), a history of VA ≤20/50 (P = .002), VA ≤20/200 (P < .001), and a higher rate of complications (P < .001). On multivariable analysis, non-Hispanic African-American race was a significant predictor of blindness (OR = 31.6, 95% CI 5.9-168.5, P < .001), after controlling for uveitis duration. Non-Hispanic African-Americans also developed 2.2 times more unique complications per year of disease than non-Hispanic whites when controlling for uveitis type and duration.
  
  
  CONCLUSIONS
  There appear to be racial differences in the outcomes of children with uveitis. Non-Hispanic African-American children with non-juvenile idiopathic arthritis-associated uveitis may have worse visual outcomes with increased vision loss and ocular complications. These findings highlight the need for future studies in minority populations.
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia. Electronic address: sangele@emory.edu.
authors.forename: Sheila T
authors.initials: ST
authors.lastname: Angeles-Han
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Courtney
authors.initials: C
authors.lastname: McCracken
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Steven
authors.initials: S
authors.lastname: Yeh
authors.affiliation: Children's Healthcare of Atlanta, Atlanta, Georgia.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Jenkins
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Daneka
authors.initials: D
authors.lastname: Stryker
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Curtis
authors.initials: C
authors.lastname: Travers
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Children's Healthcare of Atlanta, Atlanta, Georgia.
authors.forename: Kelly
authors.initials: K
authors.lastname: Rouster-Stevens
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Children's Healthcare of Atlanta, Atlanta, Georgia.
authors.forename: Larry B
authors.initials: LB
authors.lastname: Vogler
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Lambert
authors.affiliation: Rollins School of Public Health, Emory University, Atlanta, Georgia.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Drews-Botsch
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Children's Healthcare of Atlanta, Atlanta, Georgia.
authors.forename: Sampath
authors.initials: S
authors.lastname: Prahalad
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D008297:Male; D015995:Prevalence; D044469:Racial Groups; D012189:Retrospective Studies; D012307:Risk Factors; D014605:Uveitis / Q000208:ethnology*; D014792:Visual Acuity