title: Molecular and clinical diseasome of comorbidities in exacerbated COPD patients.
abstract: The frequent occurrence of comorbidities in patients with chronic obstructive pulmonary disease (COPD) suggests that they may share pathobiological processes and/or risk factors.To explore these possibilities we compared the clinical diseasome and the molecular diseasome of 5447 COPD patients hospitalised because of an exacerbation of the disease. The clinical diseasome is a network representation of the relationships between diseases, in which diseases are connected if they co-occur more than expected at random; in the molecular diseasome, diseases are linked if they share associated genes or interaction between proteins.The results showed that about half of the disease pairs identified in the clinical diseasome had a biological counterpart in the molecular diseasome, particularly those related to inflammation and vascular tone regulation. Interestingly, the clinical diseasome of these patients appears independent of age, cumulative smoking exposure or severity of airflow limitation.These results support the existence of shared molecular mechanisms among comorbidities in COPD.
authors.affiliation: Fundació Privada Clinic per a la Recerca Biomèdica, Barcelona, Spain CIBER Enfermedades Respiratorias (CIBERES), Spain Co-primary authors.
authors.forename: Rosa
authors.initials: R
authors.lastname: Faner
authors.affiliation: Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain Co-primary authors.
authors.forename: Alba
authors.initials: A
authors.lastname: Gutiérrez-Sacristán
authors.affiliation: CIBER Enfermedades Respiratorias (CIBERES), Spain Instituto de Investigación, Hospital 12 de Octubre, Madrid, Spain.
authors.forename: Ady
authors.initials: A
authors.lastname: Castro-Acosta
authors.affiliation: Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Solène
authors.initials: S
authors.lastname: Grosdidier
authors.affiliation: Dept of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY, USA.
authors.forename: Wenqi
authors.initials: W
authors.lastname: Gan
authors.affiliation: Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Milagros
authors.initials: M
authors.lastname: Sánchez-Mayor
authors.affiliation: CIBER Enfermedades Respiratorias (CIBERES), Spain Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Lopez-Campos
authors.affiliation: CIBER Enfermedades Respiratorias (CIBERES), Spain Instituto de Investigación, Hospital 12 de Octubre, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Pozo-Rodriguez
authors.affiliation: Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Ferran
authors.initials: F
authors.lastname: Sanz
authors.affiliation: Dept of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Mannino
authors.affiliation: Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Laura I
authors.initials: LI
authors.lastname: Furlong
authors.affiliation: Fundació Privada Clinic per a la Recerca Biomèdica, Barcelona, Spain CIBER Enfermedades Respiratorias (CIBERES), Spain Thorax Institute, Hospital Clinic, IDIBAPS, Univ. Barcelona, Barcelona, Spain alvar.agusti@clinic.ub.es.
authors.forename: Alvar
authors.initials: A
authors.lastname: Agusti
mesh_terms: D000368:Aged; D000465:Algorithms; D054869:Clinical Audit; D015897:Comorbidity; D003625:Data Collection; D005260:Female; D006760:Hospitalization; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D025941:Protein Interaction Mapping; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000453:epidemiology* / Q000378:metabolism; D012307:Risk Factors; D012907:Smoking; D012984:Software