title: Novel hematologic inflammatory parameters to predict acute mesenteric ischemia.
abstract: Acute mesenteric ischaemia (AMI) is an emergency condition that requires urgent diagnosis. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have been studied as inflammatory biomarkers in atherosclerosis, but data regarding AMI are lacking. The study population included patients with AMI (n = 46) versus age and sex-matched healthy controls (n = 46). Computed multidetector tomographic angiography was performed to diagnose AMI. NLR and PLR were calculated using complete blood count. C-reactive protein (CRP) levels were also analyzed. Neutrophil levels and lymphocytes were significantly higher in patients with AMI than in the control individuals (P < 0.001 and P = 0.43, respectively). NLR levels were significantly higher in patients with AMI compared with that in the control individuals (P < 0.001). Platelet levels did not reach statistical significance between the groups (P = 0.709). However, patients with AMI had significantly higher PLR levels than the control group (P = 0.039). CRP levels on admission were higher in patients with AMI in comparison with control individuals. There was also a positive correlation between NLR and CRP (r = 0.548, P < 0.001), and between PLR and CRP (r = 0.528, P < 0.001). NLR level greater than 4.5, measured on admission, yielded an area under the curve value of 0.790 (95% confidence interval 0.681-0.799, sensitivity 77%, specificity 72%), and PLR level of greater than 157 yielded an area under the curve value of 0.604 (95% confidence interval 0.486-0.722, sensitivity 59%, specificity 65%). Patients with AMI had increased NLR, PLR, and CRP levels compared with controls. Increased NLR and PLR was an independent predictor of AMI.
authors.affiliation: aHaseki Research and Education Hospital, Anesthesiology Clinic bHaseki Research and Education Hospital, Radiology Clinic İstanbul cSakarya Research and Education Hospital, Anesthesiology Clinic, Sakarya dHaseki Research and Education Hospital, Cardiology Clinic, İstanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Toptas
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Akkoc
authors.forename: Yildiray
authors.initials: Y
authors.lastname: Savas
authors.forename: Sinan
authors.initials: S
authors.lastname: Uzman
authors.forename: Yasar
authors.initials: Y
authors.lastname: Toptas
authors.forename: Mehmet Mustafa
authors.initials: MM
authors.lastname: Can
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D065666:Mesenteric Ischemia / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*; D010976:Platelet Count; D012372:ROC Curve; D014055:Tomography, Emission-Computed
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein