title: Huge familial colloid cyst of the third ventricle: An extraordinary presentation.
abstract: BACKGROUND
  Since the use of computed tomography and magnetic resonance imaging, colloid cysts (CCs) are discovered more frequently and subsequently their true incidence exceeds the numbers previously estimated. In 1986, the first familial case was reported in two identical twin brothers. To date, a total of 17 of these cases have been reported, all differing in the pattern of affected family members.
  
  
  METHODS
  Here, we describe a unique presentation of a familial case and review the relevant literature on CCs and their natural history to improve our understanding of these cases.
  
  
  CONCLUSIONS
  Familial CC can present in various patterns, sizes, and forms. A genetic factor is likely to be responsible in these cases, and further research is warranted to clarify this phenomenon.
authors.affiliation: Department of Neurosurgery, University Hospitals Leuven, Belgium.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Niknejad
authors.affiliation: Department of Neurosurgery, International Neuroscience Institute, D-30625 Hannover, Germany.
authors.forename: Amir
authors.initials: A
authors.lastname: Samii
authors.affiliation: Department of Neurosurgery, International Neuroscience Institute, D-30625 Hannover, Germany.
authors.forename: Shang-Hang
authors.initials: SH
authors.lastname: Shen
authors.affiliation: Department of Neurosurgery, International Neuroscience Institute, D-30625 Hannover, Germany.
authors.forename: Majid
authors.initials: M
authors.lastname: Samii
keywords: Colloid cyst; familial; genetics; tumor