title: Ginsenoside Rg3 attenuated omethoate-induced lung injury in rats.
abstract: Organophosphorus exposure affects different organs such as the lung, gastrointestinal tract, liver, and brain. The present experiment aimed to evaluate the effect of ginsenoside Rg3 on lung injury induced by acute omethoate poisoning. Rats were administered with omethoate subcutaneously at a single dose of 60 mg/kg, followed by ginsenoside Rg3 (5, 10, or 20 mg/kg) treatment. Histopathological examination of the lung was performed at 24 h after the omethoate exposure. The antioxidative parameters in the lung were also assayed. Moreover, the activities of acetylcholinesterase, myeloperoxidase, and the content of tumor necrosis factor α (TNF-α) in the lung were determined. The results showed that ginsenoside Rg3 attenuated omethoate-induced lung injury. Ginsenoside Rg3 increased the level of glutathione in the lung (p < 0.05 or p < 0.01). The altered activities of superoxide dismutase and catalase in the lung were also ameliorated by ginsenoside Rg3 treatment (p < 0.05 or p < 0.01). Ginsenoside Rg3 caused significant reductions in the contents of malondialdehyde, TNF-α, and the activity of myeloperoxidase (p < 0.05 or p < 0.01). The present study demonstrated that ginsenoside Rg3 had a protective effect against omethoate-induced lung injury in rats, and the mechanisms were related to its antioxidant potential and anti-inflammatory effect.
authors.affiliation: Department of Respiratory Medicine, China-Japan Union Hospital, Changchun, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, School of Pharmacy, Jilin University, Changchun, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Yu
authors.affiliation: Department of Respiratory Medicine, China-Japan Union Hospital, Changchun, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Zhao
authors.affiliation: Department of Respiratory Medicine, China-Japan Union Hospital, Changchun, China.
authors.forename: S M
authors.initials: SM
authors.lastname: Shi
authors.affiliation: Dalian Fusheng Natural Medicine Development Co., Ltd, Dalian, China.
authors.forename: L
authors.initials: L
authors.lastname: Fu
authors.affiliation: Department of Pharmacology, School of Pharmacy, Jilin University, Changchun, China dayuansui@163.com.
authors.forename: D Y
authors.initials: DY
authors.lastname: Sui
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D004117:Dimethoate / Q000031:analogs & derivatives* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D036145:Ginsenosides / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D055370:Lung Injury / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D004785:Environmental Pollutants; D036145:Ginsenosides; D014409:Tumor Necrosis Factor-alpha; C097367:ginsenoside Rg3; C002302:dimethoxon; D004117:Dimethoate
keywords: Ginsenoside Rg3; anti-inflammatory effect; antioxidant; lung injury; omethoate