title: Hybrid volatolomics and disease detection.
abstract: This Review presents a concise, but not exhaustive, didactic overview of some of the main concepts and approaches related to "volatolomics"-an emerging frontier for fast, risk-free, and potentially inexpensive diagnostics. It attempts to review the source and characteristics of volatolomics through the so-called volatile organic compounds (VOCs) emanating from cells and their microenvironment. It also reviews the existence of VOCs in several bodily fluids, including the cellular environment, blood, breath, skin, feces, urine, and saliva. Finally, the usefulness of volatolomics for diagnosis from a single bodily fluid, as well as ways to improve these diagnostic aspects by "hybrid" approaches that combine VOC profiles collected from two or more bodily fluids, will be discussed. The perspectives of this approach in developing the field of diagnostics to a new level are highlighted.
authors.affiliation: The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 3200003 (Israel).
authors.forename: Yoav Y
authors.initials: YY
authors.lastname: Broza
authors.affiliation: Breath Research Institute and University-Clinic for Anesthesia, The University of Innsbruck and Innsbruck Medical University, Innsbruck (Austria).
authors.forename: Pawel
authors.initials: P
authors.lastname: Mochalski
authors.affiliation: Breath Research Institute and University-Clinic for Anesthesia, The University of Innsbruck and Innsbruck Medical University, Innsbruck (Austria).
authors.forename: Vera
authors.initials: V
authors.lastname: Ruzsanyi
authors.affiliation: Breath Research Institute and University-Clinic for Anesthesia, The University of Innsbruck and Innsbruck Medical University, Innsbruck (Austria).
authors.forename: Anton
authors.initials: A
authors.lastname: Amann
authors.affiliation: The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 3200003 (Israel). hhossam@technion.ac.il.
authors.forename: Hossam
authors.initials: H
authors.lastname: Haick
mesh_terms: D001826:Body Fluids / Q000737:chemistry; D003933:Diagnosis; D006801:Humans; D055549:Volatile Organic Compounds / Q000032:analysis
chemical_list: D055549:Volatile Organic Compounds
keywords: breath; diagnosis; skin; volatile organic compounds; volatolomics