title: Flicker defined form, standard perimetry and Heidelberg retinal tomography: Structure-function relationships.
abstract: OBJECTIVE
  To compare flicker defined form (FDF) perimetry using the Heidelberg edge perimeter (HEP) with standard automated perimetry (SAP) on the Humphrey visual field (HVF) analyzer and to compare their relationship to structural measurements acquired with the Heidelberg retina tomograph.
  
  
  METHODS
  Prospective, observational study.
  
  
  METHODS
  Thirty-one glaucomatous eyes with varying severity and 13 normal control eyes were included in this analysis.
  
  
  METHODS
  All subjects underwent FDF testing on the HEP using the 24-2 protocol by the adaptive staircase thresholding algorithm standard strategy and SAP on the HVF analyzer 750 II using the SITA-Standard 24-2 test. Heidelberg retina tomography (HRT) testing was obtained for each patient. Spearman correlation coefficient, mean deviation (MD), and pattern standard deviation measurements by both machines were compared.
  
  
  RESULTS
  FDF and SAP MD were significantly correlated (r = 0.81, p < 0.001). FDF and SAP MD were significantly correlated with HRT cup/disc ratio (FDF MD: p < 0.001; SAP MD: p = 0.003), disc area (FDF MD: p = 0.005; SAP MD: p = 0.059), rim volume (FDF MD: p < 0.001; SAP MD: p < 0.001), and retinal nerve fibre layer (FDF MD: p < 0.001; SAP MD: p < 0.001).
  
  
  CONCLUSIONS
  This pilot study shows that the MD parameter of FDF correlated with SAP results. FDF and SAP had significant correlations with HRT parameters in glaucomatous and healthy eyes. The potential utility of FDF in the clinical management of glaucoma requires further investigation.
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital.
authors.forename: Parul
authors.initials: P
authors.lastname: Ichhpujani
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital.
authors.forename: David C
authors.initials: DC
authors.lastname: Lo
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital.
authors.forename: Victor
authors.initials: V
authors.lastname: Cvintal
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital.
authors.forename: Michael
authors.initials: M
authors.lastname: Waisbourd
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital.
authors.forename: Adam
authors.initials: A
authors.lastname: Averbuch
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pa.
authors.forename: Benjamin E
authors.initials: BE
authors.lastname: Leiby
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital.
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Myers
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital.
authors.forename: George L
authors.initials: GL
authors.lastname: Spaeth
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital. Electronic address: ljkatz@willseye.org.
authors.forename: L Jay
authors.initials: LJ
authors.lastname: Katz
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D019540:Area Under Curve; D001369:Axons / Q000473:pathology*; D005260:Female; D005901:Glaucoma / Q000145:classification / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D010865:Pilot Projects; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D014054:Tomography; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*