title: Antibacterial and Antifungal Activity of ZnO Containing Glasses.
abstract: A new family of non-toxic biocides based on low melting point (1250°C) transparent glasses with high content of ZnO (15-40wt%) belonging to the miscibility region of the B2O3-SiO2-Na2O-ZnO system has been developed. These glasses have shown an excellent biocide activity (logarithmic reduction >3) against Gram- (E. coli), Gram+ (S. aureus) and yeast (C. krusei); they are chemically stable in different media (distilled water, sea-like water, LB and DMEN media) as well as biocompatible. The cytotoxicity was evaluated by the Neutral Red Uptake using NIH-3T3 (mouse embryonic fibroblast cells) and the cell viability was >80%. These new glasses can be considered in several and important applications in the field of inorganic non-toxic biocide agents such as medical implants, surgical equipment, protective apparels in hospitals, water purifications systems, food packaging, food storages or textiles.
authors.affiliation: Department of Biomaterials and Bioinspired Materials, Materials Science Institute of Madrid, (ICMM), Spanish National Research Council (CSIC), Cantoblanco, Madrid, 28049, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Esteban-Tejeda
authors.affiliation: Nanomaterials and Nanotechnology Research Center, Spanish National Research Council-Universidad de Oviedo-Principado de Asturias, (CINN-CSIC-UNIOVI-PA), Avenida de la Vega, 4-6, 33940, El Entrego, Asturias, Spain.
authors.forename: Catuxa
authors.initials: C
authors.lastname: Prado
authors.affiliation: Nanomaterials and Nanotechnology Research Center, Spanish National Research Council-Universidad de Oviedo-Principado de Asturias, (CINN-CSIC-UNIOVI-PA), Avenida de la Vega, 4-6, 33940, El Entrego, Asturias, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Cabal
authors.affiliation: Department of Biomaterials and Bioinspired Materials, Materials Science Institute of Madrid, (ICMM), Spanish National Research Council (CSIC), Cantoblanco, Madrid, 28049, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Sanz
authors.affiliation: Nanomaterials and Nanotechnology Research Center, Spanish National Research Council-Universidad de Oviedo-Principado de Asturias, (CINN-CSIC-UNIOVI-PA), Avenida de la Vega, 4-6, 33940, El Entrego, Asturias, Spain; Moscow State University of Technology STANKIN, Vadkovskij per. 1, Moscow Oblast, 101472, Moscow, Russian Federation.
authors.forename: Ramón
authors.initials: R
authors.lastname: Torrecillas
authors.affiliation: Department of Biomaterials and Bioinspired Materials, Materials Science Institute of Madrid, (ICMM), Spanish National Research Council (CSIC), Cantoblanco, Madrid, 28049, Spain.
authors.forename: José Serafín
authors.initials: JS
authors.lastname: Moya
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D015034:Zinc Oxide / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001672:Biocompatible Materials; D015034:Zinc Oxide