title: [Novel hybrids of (phenylsulfonyl)furoxan and N-benzyl matrinol as anti-hepatocellular carcinoma agents].
abstract: N-Benzyl matrinol was obtained by hydrolysis, benzylation and reduction reaction from matrine. A series of hybrids (8a-8n) from (phenylsulfonyl)furoxan and N-benzyl matrinol were synthesized and biologically evaluated as anti-hepatocellular carcinoma agents. All target compounds were evaluated for anti-proliferative activity against human hepatocellular Bel-7402, SMMC-7721, Bel-7404, and HepG2 cells in vitro by MTT method. The results indicated that all of these compounds had potent anti-proliferative activity which were more potent than their parent compound and 5-FU, especially 8a-8h and 8j showed the strongest anti-HCC HepG2 cell activity with IC50 values of 0.12-0.93 μmol x L(-1).
authors.forename: Li-qin
authors.initials: LQ
authors.lastname: He
authors.forename: Qi
authors.initials: Q
authors.lastname: Yang
authors.forename: Ya-xian
authors.initials: YX
authors.lastname: Wu
authors.forename: Xiao-shan
authors.initials: XS
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular; D005472:Fluorouracil; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms; D010069:Oxadiazoles / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010069:Oxadiazoles; C010166:furoxans; D005472:Fluorouracil