title: Stereotactic body radiotherapy (SBRT) for the treatment of inoperable stage I non-small cell lung cancer patients.
abstract: BACKGROUND
  Lung cancer is the most frequent neoplasm in humans. Surgery is considered the best therapeutic approach for stage I non-small lung cell cancer (NSCLC). However, a remarkable amount of patients are considered as inoperable. Stereotactic body radiotherapy (SBRT) has risen as an option for those patients, rendering excellent results in quality of life and survival.
  
  
  METHODS
  We analyzed clinical studies published between 2002 and 2015 which included SBRT as a treatment modality. Our own clinical series was analyzed as well. The patterns of failure following SBRT were investigated, together with the outcomes and the toxicity observed.
  
  
  RESULTS
  SBRT has proven to maintain an excellent local control. The analysis showed the tumor size and the histology as determinant factors for the response to treatment.
  
  
  CONCLUSIONS
  According to the published evidence as well as our own experience, SBRT is a safe and feasible approach for early NSCLC. Its results may be comparable with surgery treatment.
authors.affiliation: Department of Oncology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Ceniceros
authors.affiliation: Department of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Aristu
authors.affiliation: Department of Oncology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Castañón
authors.affiliation: Oncology Department and Multidisciplinary Oncology Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Rolfo
authors.affiliation: Department of Oncology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Legaspi
authors.affiliation: Department of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Olarte
authors.affiliation: Department of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Valtueña
authors.affiliation: Department of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Moreno
authors.affiliation: Department of Oncology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain. igbazo@unav.es.
authors.forename: I
authors.initials: I
authors.lastname: Gil-Bazo
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D016634:Radiosurgery; D016896:Treatment Outcome
keywords: Inoperable patients; Non-small lung cancer; Stage I; Stereotactic body radiotherapy