title: Mesenchymal Stromal Cells: Updates and Therapeutic Outlook in Rheumatic Diseases.
abstract: Multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are adult stem cells exhibiting functional properties that have opened the way for cell-based clinical therapies. MSCs have been reported to exhibit immunosuppressive as well as healing properties, improving angiogenesis and preventing apoptosis or fibrosis through the secretion of paracrine mediators. This review summarizes recent progress on the clinical application of stem cells therapy in some inflammatory and degenerative rheumatic diseases. To date, most of the available data have been obtained in preclinical models and clinical efficacy needs to be evaluated through controlled randomized double-blind trials.
authors.affiliation: Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital, 371, Avenue du Doyen Gaston Giraud, Montpellier 34295, France. ympers2000@yahoo.fr.
authors.forename: Yves-Marie
authors.initials: YM
authors.lastname: Pers
authors.affiliation: Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital, 371, Avenue du Doyen Gaston Giraud, Montpellier 34295, France. christian.jorgensen@inserm.fr.
authors.forename: Christian
authors.initials: C
authors.lastname: Jorgensen
keywords: autoimmune diseases; immune tolerance; mesenchymal stem cells; osteoarthritis; rheumatic diseases; rheumatoid arthritis