title: Hemolytic Disorders Causing Severe Neonatal Hyperbilirubinemia.
abstract: A shortened erythrocyte life span, because of hemolytic disorders, is a common cause of extreme neonatal hyperbilirubinemia. Clinical and laboratory examinations can frequently identify the underlying cause of extreme neonatal hyperbilirubinemia. In this article, several tests, techniques, and approaches have been reviewed, including red blood cell morphology assessment, end-tidal carbon monoxide quantification, eosin-5-maleimide flow cytometry, as well as next-generation DNA sequencing using neonatal jaundice panels.
authors.affiliation: Women and Newborn's Program, Division of Neonatology, Department of Pediatrics, Intermountain Healthcare, University of Utah School of Medicine, 295 Chipeta Way, Salt Lake City, UT 84108, USA; Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address: Robert.christensen@hsc.utah.edu.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Christensen
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Yaish
mesh_terms: D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000175:diagnosis / Q000209:etiology*; D007231:Infant, Newborn; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Anemia; BIND; Bilirubin; End-tidal carbon monoxide; Hemoglobin; Jaundice; Kernicterus; Next-generation DNA sequencing