title: Study of blood flow in several benchmark micro-channels using a two-fluid approach.
abstract: It is known that in a vessel whose characteristic dimension (e.g., its diameter) is in the range of 20 to 500 microns, blood behaves as a non-Newtonian fluid, exhibiting complex phenomena, such as shear-thinning, stress relaxation, and also multi-component behaviors, such as the Fahraeus effect, plasma-skimming, etc. For describing these non-Newtonian and multi-component characteristics of blood, using the framework of mixture theory, a two-fluid model is applied, where the plasma is treated as a Newtonian fluid and the red blood cells (RBCs) are treated as shear-thinning fluid. A computational fluid dynamic (CFD) simulation incorporating the constitutive model was implemented using OpenFOAM® in which benchmark problems including a sudden expansion and various driven slots and crevices were studied numerically. The numerical results exhibited good agreement with the experimental observations with respect to both the velocity field and the volume fraction distribution of RBCs.
authors.affiliation: Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
authors.forename: Wei-Tao
authors.initials: WT
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Antaki
authors.affiliation: Department of Mechanical Engineering, Northeastern University, Boston, MA, 02115, USA.
authors.forename: Nadine
authors.initials: N
authors.lastname: Aubry
authors.affiliation: U. S. Department of Energy, National Energy Technology Laboratory (NETL), PA, 15236, USA.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Massoudi
keywords: Blood; crevices; micro-channels; mixture theory; shear-thinning; two-component flow