title: Chronic Noise Exposure Acts Cumulatively to Exacerbate Alzheimer's Disease-Like Amyloid-β Pathology and Neuroinflammation in the Rat Hippocampus.
abstract: A putative etiological association exists between noise exposure and Alzheimer's disease (AD). Amyloid-β (Aβ) pathology is thought to be one of the primary initiating factors in AD. It has been further suggested that subsequent dysregulation of Aβ may play a mechanistic role in the AD-like pathophysiology associated with noise exposure. Here, we used ELISA, immunoblotting, cytokine arrays, and RT-PCR, to examine both hippocampal Aβ pathology and neuroinflammation in rats at different time points after noise exposure. We found that chronic noise exposure significantly accelerated the progressive overproduction of Aβ, which persisted for 7 to 14 days after the cessation of exposure. This effect was accompanied by up-regulated expression of amyloid precursor protein (APP) and its cleavage enzymes, β- and γ-secretases. Cytokine analysis revealed that chronic noise exposure increased levels of tumor necrosis factor-α and the receptor for advanced glycation end products, while decreasing the expression of activin A and platelet-derived growth factor-AA. Furthermore, we found persistent elevations of glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 expression that closely corresponded to the noise-induced increases in Aβ and neuroinflammation. These studies suggest that lifelong environmental noise exposure may have cumulative effects on the onset and development of AD.
authors.affiliation: Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Cui
authors.affiliation: Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Li
authors.affiliation: 1] Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China [2] Shandong academy of occupational health and occupational medicine, Shandong academy of medical sciences, Jinan, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Gai
authors.affiliation: Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: She
authors.affiliation: Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Chuanxiang
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Gaihong
authors.initials: G
authors.lastname: An
authors.affiliation: Department of Occupational Hygiene, Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Shandong academy of occupational health and occupational medicine, Shandong academy of medical sciences, Jinan, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D028341:Activins / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009622:Noise / Q000009:adverse effects*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015854:Up-Regulation / Q000502:physiology
chemical_list: C100745:Aif1 protein, rat; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D010982:Platelet-Derived Growth Factor; D000067759:Receptor for Advanced Glycation End Products; D014409:Tumor Necrosis Factor-alpha; C422405:activin A; D028341:Activins; D053829:Amyloid Precursor Protein Secretases