title: Secondary corneal amyloidosis after perforating corneal trauma: A series of 5 cases and review of the literature.
abstract: We retrospectively reviewed the clinical and surgical histories of 5 patients with traumatic secondary corneal amyloidosis, a relatively rare sequela of nonsurgical and surgical perforating corneal trauma. Four had history of nonsurgical trauma, and 1 had surgical trauma to the cornea. Three specimens were obtained by penetrating keratoplasties and 2 by excision of the cornea during evisceration of the ocular contents. All the corneal specimens showed full-thickness scars of a prior perforating wound with congophilic amyloid deposits that exhibited apple-green birefringence under polarized light and dichroism. All cases had variable degrees of predominantly chronic nongranulomatous inflammation. Ultrastructural examination in 1 patient disclosed 8-nm diameter fibrils in disarray, consistent with amyloid. Amyloid P immunostaining was positive in all 3 patients tested for this protein.
authors.affiliation: Department of Ophthalmology, The Ottawa Hospital, Ottawa, Ontario, Canada; Department of Pathology, The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: Solin
authors.initials: S
authors.lastname: Saleh
authors.affiliation: Department of Ophthalmology, The Ottawa Hospital, Ottawa, Ontario, Canada; Department of Pathology, The Ottawa Hospital, Ottawa, Ontario, Canada. Electronic address: sbrownstein@ohri.ca.
authors.forename: Seymour
authors.initials: S
authors.lastname: Brownstein
authors.affiliation: Department of Ophthalmology, The Ottawa Hospital, Ottawa, Ontario, Canada; Department of Pathology, The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Manusow
authors.affiliation: Department of Ophthalmology, The Ottawa Hospital, Ottawa, Ontario, Canada; Department of Pathology, The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: André
authors.initials: A
authors.lastname: Jastrzebski
authors.affiliation: Department of Ophthalmology, The Ottawa Hospital, Ottawa, Ontario, Canada; Department of Pathology, The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: Kay
authors.initials: K
authors.lastname: Lam
authors.affiliation: Department of Ophthalmology, Milton S. Hershey Medical Centre, Pennsylvania State University, Hershey, Pennsylvania, USA; Department of Pathology, Milton S. Hershey Medical Centre, Pennsylvania State University, Hershey, Pennsylvania, USA.
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Sassani
authors.affiliation: Department of Ophthalmology, The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: George
authors.initials: G
authors.lastname: Mintsioulis
authors.affiliation: Department of Ophthalmology, The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Gilberg
mesh_terms: D000328:Adult; D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D003316:Corneal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D065306:Corneal Injuries / Q000150:complications*; D057112:Corneal Perforation / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000682:Amyloid
keywords: amyloid; cornea; corneal degeneration; pathology; perforating corneal trauma; secondary corneal amyloidosis