title: Long-term ascorbic acid administration causes anticonvulsant activity during moderate and long-duration swimming exercise in experimental epilepsy.
abstract: The benefits of regular exercise on brain health are undeniable. Long-term exercise increases the production of reactive oxygen species in brain. Therefore, athletes often consume antioxidant supplements to remedy exercise-related damage and fatigue during exercise. The aim of this study is to evaluate the role of ascorbic acid in the effects of different intensities of swimming exercise on the brain susceptibility to experimental epilepsy in rats. Ascorbic acid was administered intraperitoneally (ip) during three different swimming exercise programme for 90 days (15 min, 30 min, 90 min/day). The anticonvulsant activity regarding the frequency of epileptiform activity appeared in the 80 min after 500 units intracortical penicillin injection in 30 min and 90 min/day exercise groups. The administration of ascorbic acid (100 mg/kg, ip) did not alter the anticonvulsant properties seen in the in short-duration (15 min/day) swimming exercise group. The amplitude of epileptiform activity also became significant in the 110 and 120 min after penicillin injection in the moderate (30 min/day) and long duration (60 min/day) groups, respectively. The results of the present study provide electrophysiologic evidence that long-term administration of ascorbic acid causes anticonvulsant activities in the moderate and long-duration swimming exercise. Antioxidant supplementation such as ascorbic acid might be suggested for moderate and long-duration swimming exercise in epilepsy.
authors.affiliation: Faculty of Yasar Dogu Sport Sciences, University of Ondokuz Mayis, Samsun, Turkey.
authors.forename: Erkut
authors.initials: E
authors.lastname: Tutkun
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Arslan
authors.affiliation: Faculty of Yasar Dogu Sport Sciences, University of Ondokuz Mayis, Samsun, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Soslu
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ayyildiz
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey, Email: eragar@omu.edu.tr.
authors.forename: Erdal
authors.initials: E
authors.lastname: Agar
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy*; D005081:Exercise Therapy / Q000379:methods; D008297:Male; D010805:Physical Conditioning, Animal; D017208:Rats, Wistar; D013550:Swimming / Q000502:physiology*; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D001205:Ascorbic Acid