title: Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave Ripples.
abstract: Whether the activation of spiking cell ensembles can be encoded in the local field potential (LFP) remains unclear. We address this question by combining in vivo electrophysiological recordings in the rat hippocampus with realistic biophysical modeling, and explore the LFP of place cell sequence spiking ("replays") during sharp wave ripples. We show that multi-site perisomatic LFP amplitudes, in the ∼150-200 Hz frequency band, reliably reflect spatial constellations of spiking cells, embedded within non-spiking populations, and encode activation of local place cell ensembles during in vivo replays. We find spatiotemporal patterns in the LFP, which remain consistent between sequence replays, in conjunction with the ordered activation of place cell ensembles. Clustering such patterns provides an efficient segregation of replay events from non-replay-associated ripples. This work demonstrates how spatiotemporal ensemble spiking is encoded extracellularly, providing a window for efficient, LFP-based detection and monitoring of structured population activity in vivo.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: jtaxidis@ucla.edu.
authors.forename: Jiannis
authors.initials: J
authors.lastname: Taxidis
authors.affiliation: Allen Institute for Brain Science, Seattle, WA 98103, USA; Department of Neurology, University of British Columbia, Vancouver, V5Z 3N9 BC, Canada.
authors.forename: Costas A
authors.initials: CA
authors.lastname: Anastassiou
authors.affiliation: Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA; Department of Psychology, University of Wisconsin at Milwaukee, Milwaukee, WI 53201, USA.
authors.forename: Kamran
authors.initials: K
authors.lastname: Diba
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA; Allen Institute for Brain Science, Seattle, WA 98103, USA.
authors.forename: Christof
authors.initials: C
authors.lastname: Koch
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D008297:Male; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D009924:Organ Culture Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D013037:Spatial Behavior / Q000502:physiology*