title: IL10 Promoter Polymorphisms are Associated with Rheumatic Heart Disease in Saudi Arabian Patients.
abstract: Rheumatic heart disease (RHD) is an inflammatory disease that develops following streptococcal infections. IL10 helps to balance immune responses to pathogens. IL10 polymorphisms have been associated with RHD, although results remain inconclusive. Our aim was to investigate the association between IL10 polymorphisms and RHD in Saudi Arabian patients. IL10 promoter polymorphisms (-1082A/G, -829C/T, and -592C/A) were genotyped in 118 RHD patients and 200 matched controls using the TaqMan allelic discrimination assay. There was a significant difference in IL10-1082 genotype frequency between patients and controls (p = 0.01). -1082G allele carriage (GG+GA vs AA) and the (-1082, -819, -592) GCC haplotype carriage were associated with an increased risk of RHD (p = 0.004, OR 2.1, 95% CIs 1.7-3.4 and p = 0.004, OR 2, 95% CIs 1.3-3.4, respectively). The ACC haplotype was associated with a decrease in RHD risk (p = 0.015, OR 0.6, 95% CIs 0.4-0.9). IL10 promoter polymorphisms may play an important role in the development of RHD and provide an opportunity for therapeutic stratification.
authors.affiliation: Cardiogenetic Team, Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
authors.forename: Atiyeh M
authors.initials: AM
authors.lastname: Abdallah
authors.affiliation: Children & Maternity Hospital, Al-Madinah, Saudi Arabia.
authors.forename: Aisha
authors.initials: A
authors.lastname: Alnuzha
authors.affiliation: Cardiogenetic Team, Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
authors.forename: Abdulhadi H
authors.initials: AH
authors.lastname: Al-Mazroea
authors.affiliation: Cardiogenetic Team, Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
authors.forename: Amr E
authors.initials: AE
authors.lastname: Eldardear
authors.affiliation: Cardiogenetic Team, Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
authors.forename: Ala Y
authors.initials: AY
authors.lastname: AlSamman
authors.affiliation: Security Forces Medical Centre, Al-Madinah, Saudi Arabia.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Almohammadi
authors.affiliation: Cardiogenetic Team, Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia. drkharbi@yahoo.com.|Children & Maternity Hospital, Al-Madinah, Saudi Arabia. drkharbi@yahoo.com.
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Al-Harbi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012214:Rheumatic Heart Disease / Q000453:epidemiology / Q000235:genetics*; D012529:Saudi Arabia / Q000453:epidemiology; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: Haplotype; Interleukin 10; Polymorphism; Rheumatic heart disease