title: High-sensitivity CRP: possible link between job stress and atherosclerosis.
abstract: BACKGROUND
  Chronic inflammation may play an important role in linking job stress to atherosclerosis. We sought to investigate the relationship between job stress and high-sensitivity C-reactive protein (hs-CRP) among Chinese workers.
  
  
  METHODS
  A total of 731 subjects (506 men and 225 women) were analyzed. Job stress was evaluated by effort-reward imbalance (ERI) model.
  
  
  RESULTS
  Among men, after adjustment for confounders, effort, overcommitment, and ERI were significantly positively correlated with hs-CRP; and reward was significantly inversely related with hs-CRP; high level of effort, overcommitment, or ERI, respectively, significantly increased the odds of high hs-CRP with ORs of 2.0, 3.5, and 3.3 (all P<0.001), compared with the corresponding low level groups. Among women, high overcommitment or ERI also increased risk of high hs-CRP with ORs of 2.8, and 4.1 (P<0.05).
  
  
  CONCLUSIONS
  High effort, overcommmitment, and ERI were positively associated with hs-CRP. Inflammation indicated by hs-CRP may be one of important mediators linking job stress and atherosclerosis.
authors.affiliation: Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China. xwxbird05@163.com
authors.forename: Weixian
authors.initials: W
authors.lastname: Xu
authors.forename: Baoxia
authors.initials: B
authors.lastname: Chen
authors.forename: Lijun
authors.initials: L
authors.lastname: Guo
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Li
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hui
authors.initials: H
authors.lastname: Zeng
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007588:Job Satisfaction; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood* / Q000150:complications / Q000523:psychology; D016017:Odds Ratio; D012201:Reward; D012307:Risk Factors; D013315:Stress, Psychological / Q000097:blood* / Q000150:complications / Q000523:psychology; D011795:Surveys and Questionnaires; D016526:Workload / Q000523:psychology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein