title: Foveal microanatomy documented by SD-OCT following treatment of advanced retinoblastoma.
abstract: Progress in the treatment of retinoblastoma has greatly improved patient survival and globe salvage rates. The introduction of intraoperative spectral domain optical coherence tomography (OCT) allows visualization of foveal anatomy and microstructure to predict visual potential and facilitate planning for visual rehabilitation. Eyes with total retinal detachments secondary to exophytic retinoblastoma have OCT findings of absence or disruption of the external limiting membrane and ellipsoid layers. We document the evolution of foveal microanatomy reconstitution following the use of chemotherapy in a 1-year-old boy and illustrate the restoration of the external limiting membrane and ellipsoid layer, thus achieving normal foveal microanatomy.
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Wasim A
authors.initials: WA
authors.lastname: Samara
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Renelle
authors.initials: R
authors.lastname: Pointdujour-Lim
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Emil Anthony T
authors.initials: EA
authors.lastname: Say
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address: carolshields@gmail.com.
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D033401:Microscopy, Acoustic; D012163:Retinal Detachment / Q000503:physiopathology; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D012175:Retinoblastoma / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014750:Vincristine / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin