title: Pregnancy Loss Following Amniocentesis or CVS Sampling-Time for a Reassessment of Risk.
abstract: Risk of procedure-related pregnancy loss is currently widely quoted in the UK as 1% for amniocentesis and 1.5% for chorionic villus sampling. Published data suggest that these risk figures are out of date and inaccurate, and that new guidelines are required for pre-test counseling. It is our opinion that accurate and evidence-based information concerning miscarriage risk is vital when counseling women, as exaggeration of this risk may deter women from testing, or cause unjustified remorse if a miscarriage ensues. It is also essential that health-care economists are aware of the up-to-date evidence on "procedure-related risk" when applying risk-benefit analysis to assess new technology for non-invasive screening.
authors.affiliation: Guy's and St. Thomas' NHS Foundation Trust and King's College, London SE1 9RT, UK. caroline.ogilvie@genetics.kcl.ac.uk.
authors.forename: Caroline
authors.initials: C
authors.lastname: Ogilvie
authors.affiliation: Medway Maritime Hospital, Gillingham, Kent ME7 5NY, UK. ranjit.akolekar@nhs.net.|King's College Hospital, Denmark Hill, London SE5 9RS, UK. ranjit.akolekar@nhs.net.
authors.forename: Ranjit
authors.initials: R
authors.lastname: Akolekar
keywords: amniocentesis; cell free fetal DNA; chorionic villus sampling (CVS); miscarriage; non-invasive prenatal testing; procedure-related pregnancy loss