title: Does Supplementation with Royal Jelly Improve Oxidative Stress and Insulin Resistance in Type 2 Diabetic Patients?
abstract: BACKGROUND
  Animal studies have shown antioxidant effects of Royal Jelly (RJ) and its effect on insulin resistance as the most common complication of Type 2 diabetes. This study was conducted to determine the effect of RJ intake on serum total antioxidant capacity, Malondialdehyde and insulin resistance in T2DM.
  
  
  METHODS
  In this randomized controlled trial, forty-six type 2 diabetic patients, aged 25-65 years, with BMI of 20-30 kg/m(2), and HbA1c of 6-8% were included. The patients were randomly assigned to receive 1000 mg of RJ supplement or placebo, 3 times daily for 8 weeks. HOMA-IR, anthropometric measurements, fasting blood glucose, serum insulin, total antioxidant capacity and malondialdehyde level were measured.
  
  
  RESULTS
  In comparison with placebo, HOMA-IR decreased (P=0.015) while serum total antioxidant capacity increased significantly in RJ group (P=0.016). No significant difference was detected for serum insulin and MDA in two groups.
  
  
  CONCLUSIONS
  RJ intake may have favorable effects on serum TAC and HOMA-IR in diabetic patients.
authors.affiliation: Dept. of Nutrition, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Farzad
authors.initials: F
authors.lastname: Shidfar
authors.affiliation: Dept. of Nutrition, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Jazayeri
authors.affiliation: Dept. of Cellular & Molecular Nutrition, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyedeh Neda
authors.initials: SN
authors.lastname: Mousavi
authors.affiliation: Research Center for Endocrinology and Metabolism, Institute of Endocrinology in Firouzgar Hospital, Iran University of Medical Sciences, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Malek
authors.affiliation: Dept. of Statistics, School of Health Management and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Agha Fateme
authors.initials: AF
authors.lastname: Hosseini
authors.affiliation: Dept. of Nutrition, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Basmeh
authors.initials: B
authors.lastname: Khoshpey
keywords: Insulin resistance; Royal Jelly; Total antioxidant capacity; Type 2 diabetes mellitus