title: Structure of the BoNT/A1--receptor complex.
abstract: Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A--host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders. Towards this end, we recently solved an X-ray crystal structure of BoNT/A1 in complex with its neuronal protein receptor SV2C. Based on our findings, we discuss the potential implications for BoNT/A function.
authors.affiliation: Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
authors.forename: Roger M
authors.initials: RM
authors.lastname: Benoit
authors.affiliation: Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Frey
authors.affiliation: Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
authors.forename: Mara M
authors.initials: MM
authors.lastname: Wieser
authors.affiliation: Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Thieltges
authors.affiliation: Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
authors.forename: Rolf
authors.initials: R
authors.lastname: Jaussi
authors.affiliation: Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
authors.forename: Guido
authors.initials: G
authors.lastname: Capitani
authors.affiliation: Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland. Electronic address: richard.kammerer@psi.ch.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kammerer
mesh_terms: D000818:Animals; D019274:Botulinum Toxins, Type A / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding
chemical_list: D008562:Membrane Glycoproteins; D019274:Botulinum Toxins, Type A
keywords: BoNT/A; SV2C; Subtype; X-ray crystallography