title: Utility of the hypertriglyceridemic waist phenotype in the cardiometabolic risk assessment of youth stratified by body mass index.
abstract: It is unclear whether the hypertriglyceridemic waist phenotype (HTWP) can be used to identify those at most risk of cardiometabolic disorders.
  
  
  
  The utility of the HTWP as a useful predictor of cardiometabolic risk in youth stratified by body mass index was assessed.
  
  
  
  Three hundred and eighty-seven children (12-17.5 years) were used within this cross-sectional study. Participants were classified as normal weight or overweight/obese according to the International Obesity Task Force criteria. The HTWP phenotype was defined as having a waist circumference ≥90th percentile for age and gender with concomitant triglyceride concentrations ≥1.24 mmol L(-1) . Cardiometabolic risk profiles were compared using MANCOVA.
  
  
  
  Normal weight participants with the HTWP had significantly higher levels of C-reactive protein 2.6 ± 0.4 vs. 1.6 ± 0.3 mg L(-1) (P < 0.05) and cardiometabolic risk scores (1.3 ± 0.3 vs. -0.7 ± 0.2 and 2.1 ± 0.4 vs. -0.5 ± 0.2; both P < 0.05) compared with those of a normal weight without the HTWP. Overweight/obese participants with the HTWP had significantly higher C-reactive protein levels (3.5 ± 0.6 vs. 2.6 ± 0.5; P < 0.05) as well as both cardiometabolic risk scores (1.6 ± 0.6 vs. 0.9 ± 0.2 and 2.2 ± 0.6 vs. 0.8 ± 0.2; both P < 0.001) when compared with overweight/obese participants without the HTWP.
  
  
  
  The HTWP may serve as a simple and clinically useful approach to identify youth at increased cardiometabolic risk.
authors.affiliation: Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, Lanarkshire, UK.
authors.forename: D S
authors.initials: DS
authors.lastname: Buchan
authors.affiliation: The Physical Activity Exchange, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
authors.forename: L M
authors.initials: LM
authors.lastname: Boddy
authors.affiliation: Department of Kinesiology, Faculty of Medicine, Université Laval & Québec Heart and Lung Institute, Québec, Canada.
authors.forename: J-P
authors.initials: JP
authors.lastname: Despres
authors.affiliation: Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, Lanarkshire, UK.
authors.forename: F M
authors.initials: FM
authors.lastname: Grace
authors.affiliation: Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, Lanarkshire, UK.
authors.forename: N
authors.initials: N
authors.lastname: Sculthorpe
authors.affiliation: Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, Lanarkshire, UK.
authors.forename: C
authors.initials: C
authors.lastname: Mahoney
authors.affiliation: Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, Lanarkshire, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Baker
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D064250:Hypertriglyceridemic Waist / Q000150:complications*; D008297:Male; D050177:Overweight / Q000150:complications*; D063766:Pediatric Obesity / Q000150:complications*; D010641:Phenotype; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D015415:Biomarkers
keywords: Adolescents; cardiometabolic risk; cardiorespiratory fitness; hypertriglyceridemic waist phenotype