title: Effect of continuous versus on-demand treatment of ankylosing spondylitis with diclofenac over 2 years on radiographic progression of the spine: results from a randomised multicentre trial (ENRADAS).
abstract: BACKGROUND
  To date, only a single controlled trial provided evidence that non-steroidal anti-inflammatory drugs (NSAIDs) given continuously reduce radiographic progression compared with an on-demand therapy over 2 years in patients with ankylosing spondylitis (AS). In the current study, we tested whether such an effect of NSAIDs could be confirmed in another randomised trial.
  
  
  METHODS
  Patients with AS were randomised for treatment with either continuous (150 mg/day) or on-demand diclofenac for 2 years. Tumour necrosis factor-blocker treatment was not allowed during the entire study period. The primary outcome was the difference in radiographic progression in the spine as measured by the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) scored by two readers blinded to treatment arm and time point.
  
  
  RESULTS
  62 of 85 patients enrolled in the continuous arm and 60 of 82 enrolled in the on-demand arm completed the study. The mSASSS progression was numerically higher in the continuous group (1.28 (0.7 to 1.9) vs 0.79 (0.2 to 1.4)) (p=0.39). If only patients were analysed who were either C reactive protein positive or had syndesmophytes at baseline, there was again a higher radiographic progression in the continuous versus the on-demand group: 1.68 (0.7 to 2.6) vs 0.96 (0.0 to 1.9) and 2.11 (1.1 to 3.1) vs 0.95 (0.0 to 1.9), respectively. There was no difference between the two treatment groups regarding adverse events.
  
  
  CONCLUSIONS
  In our study, continuous treatment with diclofenac over 2 years did not reduce radiographic progression compared with on-demand treatment in AS.
  
  
  BACKGROUND
  EudraCt-no 2007-007637-39; ClinicalTrials.gov NCT00715091.
authors.affiliation: Medical Department I, Rheumatology, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany German Rheumatology Research Center, Berlin, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Sieper
authors.affiliation: German Rheumatology Research Center, Berlin, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Listing
authors.affiliation: Medical Department I, Rheumatology, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Denis
authors.initials: D
authors.lastname: Poddubnyy
authors.affiliation: Medical Department I, Rheumatology, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany Abbvie, Chicago, USA.
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Song
authors.affiliation: Department of Radiology, Charité University Medicine, Berlin, Germany.
authors.forename: Kay-Geert
authors.initials: KG
authors.lastname: Hermann
authors.affiliation: German Rheumatology Research Center, Berlin, Germany.
authors.forename: Johanna
authors.initials: J
authors.lastname: Callhoff
authors.affiliation: Medical Department I, Rheumatology, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Uta
authors.initials: U
authors.lastname: Syrbe
authors.affiliation: Rheumazentrum Herne, Herne, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Braun
authors.affiliation: Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Bielefeld, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Rudwaleit
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D004008:Diclofenac / Q000008:administration & dosage* / Q000009:adverse effects; D018450:Disease Progression; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac
keywords: Ankylosing Spondylitis; NSAIDs; Outcomes research