title: Effects of a single bout of maximal aerobic exercise on BDNF in bipolar disorder: A gender-based response.
abstract: Acute exercise increases brain-derived neurotrophic factor (BDNF) serum levels in majorly depressed and anxious patients. However, to the best of our knowledge, no study has evaluated the acute effects of exercise on BDNF serum levels in Bipolar Disorder (BD). The objective of the present study was to evaluate the peripheral BDNF serum response to a single maximum session of exercise in BD participants and age- and gender-matched healthy participants. BD participants (n=18) and age- and gender-matched healthy participants (n=18) were recruited to perform a single bout of maximal exercise on a cycle ergometer. Blood samples were collected prior to and immediately after the exercise protocol. There was a significant group effect and a significant group x time x gender interaction. BD participants presented significantly higher BDNF serum levels when compared to their healthy control counterparts. Exercise increases the BDNF levels of BD women, but not men.
authors.affiliation: Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências Médicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratório de Pesquisa do Exercício, Escola Superior de Educação Física, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: felipe.schuch@ufrgs.br.
authors.forename: Felipe Barreto
authors.initials: FB
authors.lastname: Schuch
authors.affiliation: Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências Médicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Molecular Psychiatry, and INCT for Translational Medicine, Porto Alegre, Brazil.
authors.forename: Leonardo Evangelista
authors.initials: LE
authors.lastname: da Silveira
authors.affiliation: Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil; Laboratório de Pesquisa do Exercício, Escola Superior de Educação Física, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Taís Cardoso
authors.initials: TC
authors.lastname: de Zeni
authors.affiliation: Laboratório de Pesquisa do Exercício, Escola Superior de Educação Física, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Diana Perin
authors.initials: DP
authors.lastname: da Silva
authors.affiliation: Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências Médicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Molecular Psychiatry, and INCT for Translational Medicine, Porto Alegre, Brazil.
authors.forename: Bianca
authors.initials: B
authors.lastname: Wollenhaupt-Aguiar
authors.affiliation: Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil; Laboratory of Molecular Psychiatry, and INCT for Translational Medicine, Porto Alegre, Brazil.
authors.forename: Pamela
authors.initials: P
authors.lastname: Ferrari
authors.affiliation: Laboratório de Pesquisa do Exercício, Escola Superior de Educação Física, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Reischak-Oliveira
authors.affiliation: Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências Médicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Molecular Psychiatry, and INCT for Translational Medicine, Porto Alegre, Brazil.
authors.forename: Flavio
authors.initials: F
authors.lastname: Kapczinski
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000523:psychology*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: Bipolar disorders; Brain-derived neurotrophic factor; Exercise; Neurogenesis