title: PP2A inhibition as a novel therapeutic target in castration-resistant prostate cancer.
abstract: Protein phosphatase 2A (PP2A) is a well-known tumor suppressor frequently inhibited in human cancer. Alterations affecting PP2A subunits together with the deregulation of endogenous PP2A inhibitors such as CIP2A and SET have been described as contributing mechanisms to inactivate PP2A in prostate cancer. Moreover, recent findings highlight that functional inactivation of PP2A could represent a key event in the acquisition of castration-resistant phenotype and a novel molecular target with high impact at both clinical and therapeutic levels in prostate cancer.
authors.affiliation: Pathology Department, IIS "Fundación Jiménez Diaz", Avda. Reyes Católicos-2, 28040, Madrid, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: González-Alonso
authors.forename: Ion
authors.initials: I
authors.lastname: Cristóbal
authors.forename: Rebeca
authors.initials: R
authors.lastname: Manso
authors.forename: Juan
authors.initials: J
authors.lastname: Madoz-Gúrpide
authors.forename: Jesús
authors.initials: J
authors.lastname: García-Foncillas
authors.forename: Federico
authors.initials: F
authors.lastname: Rojo
mesh_terms: D017209:Apoptosis / Q000235:genetics; D001324:Autoantigens / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D049109:Cell Proliferation / Q000235:genetics; D004268:DNA-Binding Proteins; D015972:Gene Expression Regulation, Neoplastic; D056488:Histone Chaperones / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D064129:Prostatic Neoplasms, Castration-Resistant / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D054648:Protein Phosphatase 2 / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000627:therapeutic use; D011944:Receptors, Androgen / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D001324:Autoantigens; C500266:CIP2A protein, human; D004268:DNA-Binding Proteins; D056488:Histone Chaperones; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011944:Receptors, Androgen; C513473:SET protein, human; D014157:Transcription Factors; D054648:Protein Phosphatase 2