title: Impact of the 13-valent pneumococcal conjugate vaccine on the incidence of pneumococcal meningitis in children.
abstract: The impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on the incidence of pneumococcal meningitis (PM) in children is unknown. To determine this impact, a descriptive multicentre retrospective cohort study was conducted from 2008 to 2013 in northern France. All laboratory-confirmed PM in children aged <18 years in all hospitals of the area with paediatric units were included. Two independent databases were used for exhaustive identification of cases: medical plus laboratory records at each hospital and discharge codes. The corrected incidence of PM was determined by a capture-recapture analysis using these two databases. Sixty-two cases were found over the 6-year period. A decrease of the PM corrected incidence was observed in the global population (P = 0·07), significant only for children aged <2 years, from 11·9/100 000 in 2008 in 1·9/100 000 in 2013 [6·4 fold-decrease, 95% confidence interval (CI) 1·4-41, P = 0·01] between years 2008 and 2013. When comparing the pre- and post-PCV13 periods, this decrease was still statistically significant for children aged <2 years [7·32/100 000 (95% CI 4·39-10·25) to 2·78/100 000 (95% CI 0·96-4·60), P = 0·01]. Only three (5%) cases of PM caused by vaccine serotypes could have been prevented. After the introduction of the PCV13 vaccine, a decrease in the incidence of PM cases in children in northern France was observed.
authors.affiliation: Paediatric Emergency Unit & Infectious Diseases,Centre Hospitalier Régional Universitaire,CHRU Lille,Université de Lille,France.
authors.forename: A G
authors.initials: AG
authors.lastname: Chapoutot
authors.affiliation: Microbiology laboratory,Centre Hospitalier Régional Universitaire,CHRU Lille,Université de Lille,France.
authors.forename: R
authors.initials: R
authors.lastname: Dessein
authors.affiliation: Paediatric Department,Centre Hospitalier de Calais,France.
authors.forename: O
authors.initials: O
authors.lastname: Guilluy
authors.affiliation: Paediatric Emergency Unit & Infectious Diseases,Centre Hospitalier Régional Universitaire,CHRU Lille,Université de Lille,France.
authors.forename: M
authors.initials: M
authors.lastname: Lagrée
authors.affiliation: Microbiology laboratory,Centre Hospitalier Régional Universitaire,CHRU Lille,Université de Lille,France.
authors.forename: F
authors.initials: F
authors.lastname: Wallet
authors.affiliation: Centre National de Référence du Pneumocoque,Hôpital Georges Pompidou,APHP,Paris,France.
authors.forename: E
authors.initials: E
authors.lastname: Varon
authors.affiliation: Paediatric Emergency Unit & Infectious Diseases,Centre Hospitalier Régional Universitaire,CHRU Lille,Université de Lille,France.
authors.forename: A
authors.initials: A
authors.lastname: Martinot
authors.affiliation: Paediatric Emergency Unit & Infectious Diseases,Centre Hospitalier Régional Universitaire,CHRU Lille,Université de Lille,France.
authors.forename: F
authors.initials: F
authors.lastname: Dubos
mesh_terms: D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D065186:Interrupted Time Series Analysis; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines; D012189:Retrospective Studies; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000145:classification*; D018074:Vaccines, Conjugate
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
keywords: Conjugate vaccine; Streptococcus pneumoniae; epidemiology; meningitis