title: Combined Screening for Early Detection of Pre-Eclampsia.
abstract: Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.
authors.affiliation: Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 135-081, Korea. coolsome72@chamc.co.kr.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 135-081, Korea. ogshinyss@chamc.co.kr.
authors.forename: Sung Shin
authors.initials: SS
authors.lastname: Shim
authors.affiliation: Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 135-081, Korea. chadh001@chamc.co.kr.
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Cha
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D042241:Early Diagnosis; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D004247:DNA
keywords: biomarker; cell-free fetal DNA; early prediction; maternal risk factors; mean maternal arterial pressure; pre-eclampsia; pregnancy-associated plasma protein-A (PAPP-A); ultrasound parameters