title: Electron Microscopy at Scale.
abstract: The essential details of cellular interactions at synaptic level in the brain are still largely unknown. In this issue, Kasthuri et al. report new experimental and computational technologies for large-scale electron microscopy data collection and analysis, and through saturated reconstruction uncover synaptic connectional specificity that cannot be predicted by simple axonal-dendritic proximity.
authors.affiliation: Allen Institute for Brain Science, Seattle, WA 98103, USA. Electronic address: linnaeao@alleninstitute.org.
authors.forename: Linnaea
authors.initials: L
authors.lastname: Ostroff
authors.affiliation: Allen Institute for Brain Science, Seattle, WA 98103, USA. Electronic address: hongkuiz@alleninstitute.org.
authors.forename: Hongkui
authors.initials: H
authors.lastname: Zeng
mesh_terms: D000818:Animals; D008855:Microscopy, Electron, Scanning / Q000379:methods*; D008867:Microtomy / Q000379:methods*; D019579:Neocortex / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure*