title: Osteochondral allograft transplantation in cartilage repair: Graft storage paradigm, translational models, and clinical applications.
abstract: The treatment of articular cartilage injury and disease has become an increasingly relevant part of orthopaedic care. Articular cartilage transplantation, in the form of osteochondral allografting, is one of the most established techniques for restoration of articular cartilage. Our research efforts over the last two decades have supported the transformation of this procedure from experimental "niche" status to a cornerstone of orthopaedic practice. In this Kappa Delta paper, we describe our translational and clinical science contributions to this transformation: (1) to enhance the ability of tissue banks to process and deliver viable tissue to surgeons and patients, (2) to improve the biological understanding of in vivo cartilage and bone remodeling following osteochondral allograft (OCA) transplantation in an animal model system, (3) to define effective surgical techniques and pitfalls, and (4) to identify and clarify clinical indications and outcomes. The combination of coordinated basic and clinical studies is part of our continuing comprehensive academic OCA transplant program. Taken together, the results have led to the current standards for OCA processing and storage prior to implantation and also novel observations and mechanisms of the biological and clinical behavior of OCA transplants in vivo. Thus, OCA transplantation is now a successful and increasingly available treatment for patients with disabling osteoarticular cartilage pathology.
authors.affiliation: Division of Orthopaedic Surgery, Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California.|Department of Orthopaedic Surgery, University of California-San Diego, San Diego, California.
authors.forename: William D
authors.initials: WD
authors.lastname: Bugbee
authors.affiliation: Department of Bioengineering, University of California-San Diego, La Jolla, California.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Pallante-Kichura
authors.affiliation: Department of Orthopaedic Surgery, University of California-San Diego, San Diego, California.
authors.forename: Simon
authors.initials: S
authors.lastname: Görtz
authors.affiliation: Department of Orthopaedic Surgery, University of California-San Diego, San Diego, California.
authors.forename: David
authors.initials: D
authors.lastname: Amiel
authors.affiliation: Department of Orthopaedic Surgery, University of California-San Diego, San Diego, California.|Department of Bioengineering, University of California-San Diego, La Jolla, California.
authors.forename: Robert
authors.initials: R
authors.lastname: Sah
mesh_terms: D000465:Algorithms; D000818:Animals; D016723:Bone Remodeling; D016025:Bone Transplantation / Q000379:methods*; D002356:Cartilage / Q000637:transplantation*; D002470:Cell Survival; D019902:Chondrocytes / Q000502:physiology*; D064595:Composite Tissue Allografts; D006801:Humans; D014021:Tissue Preservation
keywords: cartilage repair; osteochondral allografts