title: Synthesis of 1,2,3-triazol-1-yl-methaneboronic acids via click chemistry: an easy access to a new potential scaffold for protease inhibitors.
abstract: Stereoselective synthesis of previously unreported 1,2,3-triazol-1-yl-methaneboronic acids has been achieved from azidomethaneboronates by Copper-catalyzed Azide-Alkyne Cycloaddition (CuAAC). The proximity of the cycloaddition reaction center to the boronic group is not detrimental for the stability of thesp3-carbon-boron bond nor to the stereoisomeric composition, further expanding the field of application of click chemistry to new boronate substrates and offering a new potential scaffold for protease inhibitors.
authors.affiliation: Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio-Emilia, Via Campi 183, 41125 Modena (MO).
authors.forename: Chiara
authors.initials: C
authors.lastname: Romagnoli
authors.affiliation: Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio-Emilia, Via Campi 183, 41125 Modena (MO).
authors.forename: Emilia
authors.initials: E
authors.lastname: Caselli
authors.affiliation: Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio-Emilia, Via Campi 183, 41125 Modena (MO).
authors.forename: Fabio
authors.initials: F
authors.lastname: Prati
keywords: Cu-catalyzed Azide-Alkyne Cycloaddition; bioisoster; boron; click chemistry