title: Impact of juvenile idiopathic arthritis on quality of life during transition period at the era of biotherapies.
abstract: OBJECTIVE
  Few studies have assessed Health-Related Quality of Life (HR-QoL) in adults following juvenile idiopathic arthritis, and none since the advent of biotherapies. The aim of our study is to assess the impact of juvenile idiopathic arthritis on quality of life in a large transitional cohort, evaluate which factors influence quality of life in juvenile idiopathic arthritis, and determine which questionnaire should be used in practice.
  
  
  METHODS
  All consecutive juvenile idiopathic arthritis patients followed during adulthood in a transitional care program were included. Demographical, clinical and biological data were collected. The following quality of life questionnaires were administered: SF36 and EuroQoL. Age- and sex-matched controls (without rheumatic disease) were included.
  
  
  RESULTS
  One hundred and sixty-one juvenile idiopathic arthritis (120 women and 41 men) and 76 (51/25) controls were included. Out of 161, sixty-five (40%) were considered to be in remission. Juvenile idiopathic arthritis had a large impact on the physical scales of quality of life. Pain seemed to be the most important factor affecting quality of life in cases of juvenile idiopathic arthritis. No significant difference was found between sub-types of juvenile idiopathic arthritis.
  
  
  CONCLUSIONS
  In this large transitional cohort of patients at the era of biotherapies, juvenile idiopathic arthritis has a larger effect on physical than mental scale of quality of life measures. Pain was the main factor influencing quality of life. Sub-types of juvenile idiopathic arthritis do not seem to influence quality of life.
authors.affiliation: Paris Descartes University, Rheumatology A department, Cochin Hospital, 75014 Paris, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Wipff
authors.affiliation: Paris Descartes University, Rheumatology B department, Cochin Hospital, 75014 Paris, France; Rheumatology department, Émile-Muller Hospital, 20, avenue du Docteur-Laennec, 68100 Mulhouse, France. Electronic address: sparsal@ch-mulhouse.fr.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Sparsa
authors.affiliation: Rheumatology department, Hospital center of Belfort-Montbeliard, 90016 Belfort, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Lohse
authors.affiliation: Paris Descartes University, Pediatric department, Necker Hospital, 75015 Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Quartier
authors.affiliation: Paris Descartes University, Rheumatology A department, Cochin Hospital, 75014 Paris, France.
authors.forename: Andre
authors.initials: A
authors.lastname: Kahan
authors.affiliation: Paris Descartes University, Rheumatology A department, Cochin Hospital, 75014 Paris, France.
authors.forename: Chantal Job
authors.initials: CJ
authors.lastname: Deslandre
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000628:therapy*; D001691:Biological Therapy; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D011788:Quality of Life; D011795:Surveys and Questionnaires; D060305:Transition to Adult Care; D055815:Young Adult
keywords: Health-related quality of life; Juvenile idiopathic arthritis; Transition period