title: Gluten and IgA nephropathy: you are what you eat?
abstract: Although extensively studied, the relationship between dietary antigens-in particular, gluten-and IgA nephropathy remains unclear. Using a double transgenic mouse model of IgA nephropathy that expresses both human IgA1 and human CD89, Papista et al. report that a gluten-free diet protects against the development of IgA deposition and glomerular injury, and that these events occur with the introduction of dietary gluten.
authors.affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
authors.forename: Chee Kay
authors.initials: CK
authors.lastname: Cheung
authors.affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Barratt
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D005922:Glomerulonephritis, IGA / Q000276:immunology* / Q000378:metabolism*; D005983:Glutens / Q000633:toxicity*; D007070:Immunoglobulin A / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D011961:Receptors, Fc / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D007070:Immunoglobulin A; D011961:Receptors, Fc; D005983:Glutens