title: Evaluating resistance to acetyl salicylic acid using platelet function test in patients with ischemic stroke at Cipto Mangunkusumo Hospital.
abstract: OBJECTIVE
  to identify the prevalence of laboratoric ASA resistance using platelet function tests in patients with ischemic stroke at Cipto Mangunkusumo Hospital and its associated factors.
  
  
  METHODS
  this study was a cross-sectional study involving 50 patients with ischemic stroke who only received ASA treatment. Evaluation of resistance to ASA was performed using Verifynow® platelet function test. ASA resistance was defined as ASA reaction unit (ARU) 550.
  
  
  RESULTS
  there were 7 patients with ASA resistance. The mean age of subjects in ASA resistance group was 51.3±9.2 years; while in ASA responsive group was 57.8±9.7 years. In ASA resistance group, there were 85.7% male patients, 57.1% active smoker and 100% subjects with hypertension.
  
  
  CONCLUSIONS
  the prevalence of laboratoric ASA resistance in patients with ischemic stroke evaluated using platelet function test at Cipto Mangunkusumo Hospital is 14%. The prevalence is more likely to occur in male patients who were active smoker, at younger age and with comorbidity of hypertension.
authors.affiliation: Department of Neurology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
authors.forename: M
authors.initials: M
authors.lastname: Kurniawan
authors.forename: Salim
authors.initials: S
authors.lastname: Harris
authors.forename: Deddy
authors.initials: D
authors.lastname: Hermawan
authors.forename: Joedo
authors.initials: J
authors.lastname: Prihartono
mesh_terms: D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007214:Indonesia; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests; D012737:Sex Factors; D020521:Stroke / Q000188:drug therapy*
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin