title: Regulation and function of the Salmonella MgtC virulence protein.
abstract: Salmonella enterica serovar Typhimurium produces many virulence proteins to cause diseases. The Salmonella MgtC protein is one of such virulence proteins specially required for intracellular proliferation inside macrophages and mouse virulence. In this review, we will cover how the mgtC gene is turned on or off and what the signals required for mgtC expression are. Later in this review, we will discuss a recent understanding of MgtC function in Salmonella pathogenesis by identifying its target proteins.
authors.affiliation: Department of Genetic Engineering and Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17035, Republic of Korea.
authors.forename: Jang-Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Genetic Engineering and Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17035, Republic of Korea. eunjinlee@khu.ac.kr.
authors.forename: Eun-Jin
authors.initials: EJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D015964:Gene Expression Regulation, Bacterial; D051379:Mice; D012475:Salmonella / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D012480:Salmonella Infections / Q000382:microbiology; D014774:Virulence / Q000502:physiology; D037521:Virulence Factors / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D027682:Cation Transport Proteins; D037521:Virulence Factors; C093586:MgtC protein, Salmonella typhimurium
keywords: ATP homeostasis; Salmonella virulence; mgtC