title: Radiation reduction and faster acquisition times with SPECT gated blood pool scans using a high-efficiency cardiac SPECT camera.
abstract: Planar gated blood pool scans are an established method for the evaluation of left ventricular ejection fraction (LVEF) but the camera technology used for these studies has not significantly changed in decades. The purpose of this study was to determine the diagnostic accuracy of new high-efficiency SPECT gated blood pool scans compared to traditional scans and determine if they can be performed with lower radiation doses or faster acquisition times.
  
  
  
  Patients undergoing a planar gated blood pool scan on a Na-I SPECT camera who consented to participate were subsequently imaged for 5 minutes in "List Mode" using a high-efficiency SPECT camera. LVEF was calculated for both the planar study and at 1, 2, 3, 4, and 5 minutes of acquisition on the high-efficiency camera. Counts acquired in the field of view, counts in the cardiac blood pool and LVEF were compared.
  
  
  
  A total of 46 patients were analyzed (48% male, mean age 55 years, and BMI 27.6 kg/m(2)) who received an average Tc-99m dose of 20.3 mCi (5.3 mSv), 17 (37%) with abnormal LVEF's. The Na-I camera averaged 24,514 counts/min/mCi in the field of view and 8662 counts/min/mCi in the cardiac blood pool while the high-efficiency camera averaged 65,219 counts/min/mCi and 41,427 counts/min/mCi, respectively. Compared to the planar calculation of LVEF, 1-minute SPECT LVEF was on average 8.6 ± 10.7 higher, 2 minutes 3.5 ± 7.6 higher, 3 minutes 2.9 ± 8.5 higher, 4 minutes 2.5 ± 7.0 higher, and 5 minutes 1.1 ± 6.2 higher. Good correlation was seen between the SPECT LVEF's and the planar LVEF's across all acquisition times with correlation coefficients of 0.74-0.93.
  
  
  
  High-efficiency SPECT technology can reduce radiation exposure to patients during gated blood pool imaging or decrease acquisition time while maintaining diagnostic accuracy. Based on the improved count sensitivity with high-efficiency SPECT, a 50% reduction in injected activity may be achievable while maintaining short imaging times of 5 minutes, with further reduction possible at longer imaging times.
authors.affiliation: Hartford Hospital Division of Cardiology (Henry Low Heart Center), Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA. lane.duvall@hhchealth.org.
authors.forename: W Lane
authors.initials: WL
authors.lastname: Duvall
authors.affiliation: Mount Sinai Division of Cardiology (Mount Sinai Heart), Mount Sinai Medical Center, New York, NY, USA.
authors.forename: Krista A
authors.initials: KA
authors.lastname: Guma-Demers
authors.affiliation: Mount Sinai Division of Cardiology (Mount Sinai Heart), Mount Sinai Medical Center, New York, NY, USA.
authors.forename: Titus
authors.initials: T
authors.lastname: George
authors.affiliation: Mount Sinai Division of Cardiology (Mount Sinai Heart), Mount Sinai Medical Center, New York, NY, USA.
authors.forename: Milena J
authors.initials: MJ
authors.lastname: Henzlova
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D015902:Gamma Cameras; D015637:Gated Blood-Pool Imaging / Q000295:instrumentation*; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000032:analysis* / Q000517:prevention & control*; D011835:Radiation Protection / Q000295:instrumentation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation*
keywords: Gated blood pool scans; High-efficiency SPECT; Radiation exposure