title: Antinuclear Antibodies in Patients with Psoriatic Arthritis Treated or Not with Biologics.
abstract: BACKGROUND
  With the emergence of biotherapies, accurate diagnosis in early arthritis is needed. At this time, there is no biological marker of psoriatic arthritis.
  
  
  OBJECTIVE
  To test whether antinuclear antibodies (ANA) can be used as a diagnostic tool in psoriatic arthritis (PsA), we evaluated the prevalence of ANA in biologic-naïve PsA patients and in healthy blood donors.
  
  
  METHODS
  232 patients from the Rheumatology department, St Marguerite's Hospital, Marseilles, who fulfilled the CASPAR criteria for PsA, underwent clinical and laboratory investigations. Antinuclear antibodies (ANA), anti-extractable nuclear antigen antibodies (ENA), rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) were assayed. Ninety-one healthy blood donors were also tested.
  
  
  RESULTS
  Detection of ANA by indirect immunofluorescence was significantly more frequent in sera from PsA patients than those from controls at serum dilution of 1:100 (57% compared with 40%, Odds Ratio (OR) 1.98 (1.2-3.4) p<0.02) and 1:160 (52% compared with 24%, OR 3,7 (1.9-7.2) p<0.001). No patients had lupus specific autoantibodies, 15 % had RF (34/232), and 1.7 % had ACPA (4/232).
  
  
  CONCLUSIONS
  Detection of ANA was more frequent in sera from PsA patients than in those from healthy controls. This suggests that ANA could be a diagnosis orientation tool in PsA. Nevertheless, the specificity of these antibodies still remains to be investigated.
authors.affiliation: Rheumatology 1, IML, AP-HM, 270 Boulevard de Sainte Marguerite, 13009, Marseille, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Silvy
authors.affiliation: Laboratoire d'immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, 147 boulevard Baille, 13005, Marseille, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bertin
authors.affiliation: Laboratoire d'immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, 147 boulevard Baille, 13005, Marseille, France; INSERM UMRs 1076, UFR Pharmacie, Aix Marseille Université, 127 boulevard Jean Moulin, 13005, Marseille, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bardin
authors.affiliation: Laboratoire d'immunogénétique, INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288, Marseille, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Auger
authors.affiliation: Rheumatology 1, IML, AP-HM, 270 Boulevard de Sainte Marguerite, 13009, Marseille, France.
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Guzian
authors.affiliation: Rheumatology 1, IML, AP-HM, 270 Boulevard de Sainte Marguerite, 13009, Marseille, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Mattei
authors.affiliation: Rheumatology 1, IML, AP-HM, 270 Boulevard de Sainte Marguerite, 13009, Marseille, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Guis
authors.affiliation: Rheumatology 1, IML, AP-HM, 270 Boulevard de Sainte Marguerite, 13009, Marseille, France; Laboratoire d'immunogénétique, INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288, Marseille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Roudier
authors.affiliation: Rheumatology 1, IML, AP-HM, 270 Boulevard de Sainte Marguerite, 13009, Marseille, France; Laboratoire d'immunogénétique, INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288, Marseille, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Balandraud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D015535:Arthritis, Psoriatic / Q000097:blood* / Q000628:therapy; D001688:Biological Products / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D001688:Biological Products; D014409:Tumor Necrosis Factor-alpha