title: [Alcohol consumption patterns and genotypes determining alcohol tolerance in Chilean university students].
abstract: BACKGROUND
  Alleles involved in inefficient (ADH1B2*2 and ALDH2*2) or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk of alcoholism. Alcoholism susceptibility has been classified as protector and risk-dependence phenotypes, associated with inefficient and efficient alcohol genetic metabolizing variants, respectively.
  
  
  OBJECTIVE
  To investigate the possible association between genetic protective and risk-dependence variants and alcohol intake patterns.
  
  
  METHODS
  Saliva DNA samples were obtained and the AUDIT (Alcohol Use Disorders Identification Test) questionnaire was applied to 210 university students aged between 18 and 25 years old.
  
  
  RESULTS
  No statistically significant association between protective or risk-dependence genetic variants and alcohol pattern intake was detected. However, new categories of alcohol intake patterns-not included in the AUDIT questionnaire-were identified.
  
  
  CONCLUSIONS
  No association between the protector and risk-dependence phenotypes and patterns of alcohol consumption was detected in this sample of students.
authors.forename: Constanza P
authors.initials: CP
authors.lastname: Silva
authors.forename: Sergio V
authors.initials: SV
authors.lastname: Flores
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics* / Q000378:metabolism; D002677:Chile; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D013334:Students; D014495:Universities; D055815:Young Adult