title: Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial.
abstract: We conducted a double-blind, randomized trial of 134 outpatients with polymerase chain reaction-confirmed influenza to assess the effects of oseltamivir initiated 48-119 hours after illness onset. Oseltamivir treatment did not reduce illness duration, severity, or duration of virus detection. However, the power of this study was limited due to lower than expected enrollment.
authors.affiliation: Center for Clinical Epidemiology and Population Health.
authors.forename: Huong Q
authors.initials: HQ
authors.lastname: McLean
authors.affiliation: Center for Clinical Epidemiology and Population Health.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Belongia
authors.affiliation: Center for Clinical Epidemiology and Population Health.
authors.forename: Burney A
authors.initials: BA
authors.lastname: Kieke
authors.affiliation: Integrated Research and Development Laboratory , Marshfield Clinic Research Foundation , Wisconsin.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Meece
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Fry
keywords: influenza; oseltamivir