title: Monosynaptic excitatory transmission from the hippocampal CA1 region to the subiculum.
abstract: The subiculum is a major output region of the hippocampus, receiving inputs from the CA1 region. We obtained paired patch-clamp recordings from synaptically coupled pairs of CA1 pyramidal cells (CA1PCs) and subicular principal cells (SubPCs), using rat hippocampal organotypic slice cultures. A single action potential in a presynaptic CA1PC evoked a unitary excitatory postsynaptic current in a SubPC (EPSCCA1→Sub). The failure rate of the monosynaptic transmission was remarkably low (0.08). Paired-pulse depression in SubPCs was apparent when an interval of presynaptic action potentials was shorter than 50ms. When trains of action potentials were induced in a CA1PC, EPSCCA1→Sub was significantly depressed with increasing spike frequency (20-100Hz). Thus the unitary monosynaptic transmission from a CA1PC to a SubPC is reliable, and depressed in response to frequent inputs, suggesting that the subiculum may function as a low pass filter to provide the downstream brain regions with appropriate information.
authors.affiliation: Division of Neurophysiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Geng
authors.affiliation: Division of Neurophysiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan; Faculty of Health Sciences, Kobe University Graduate School of Health Sciences, Kobe, Japan. Electronic address: mori@gold.kobe-u.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mori
mesh_terms: D000200:Action Potentials; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials; D006624:Hippocampus / Q000502:physiology*; D051381:Rats; D009435:Synaptic Transmission; D046509:Tissue Culture Techniques
keywords: CA1; Hippocampus; Organotypic slice; Paired pulse depression; Paired recording; Subiculum; culture