title: Early evaluation of targeted therapy effectiveness in non-small cell lung cancer by dynamic contrast-enhanced CT.
abstract: OBJECTIVE
  To study the feasibility and clinical value of dynamic contrast-enhanced (DCE) computed tomography (CT) for early evaluation of targeted therapy efficacy in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  We measured tumor diameter, peak height (PH), time to peak (TP), tumor mass-aortic peak height ratio (M/A), and blood perfusion (BP) in 20 patients with advanced NSCLC using DCE-CT before and 7 days after treatment. Therapy efficacy was assessed with conventional CT 4-6 weeks post-treatment.
  
  
  RESULTS
  Patients were grouped into those with partial response (PR), stable disease (SD), and progressive disease (PD) according to the therapy efficacy assessment at 4-6 weeks post-treatment. The PR group primary tumor diameter (P = 0.0007) and BP (P = 0.0225) were reduced at 7 days post-treatment; the SD group DCE-CT value changes were not significant. The PD group M/A (P = 0.0443) and BP (P = 0.0268) were increased 7 days post-treatment. The BP decrease group had significantly longer progression-free survival than the BP increase group (median, 54 vs. 6 weeks).
  
  
  CONCLUSIONS
  DCE-CT can evaluate targeted therapy efficacy at 7 days post-treatment. Decreased primary tumor diameter and BP indicate tumor sensitivity to therapy; increased BP with unchanged tumor diameter suggests the tumor is not sensitive to therapy. Reduced BP suggests treatment effectiveness.
authors.affiliation: Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, #8 Fengtai dong street, Fengtai District, Beijing, 100071, China. qiaopenggang@sina.com.
authors.forename: P-G
authors.initials: PG
authors.lastname: Qiao
authors.affiliation: Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, #8 Fengtai dong street, Fengtai District, Beijing, 100071, China. zhanghongtao192@sina.com.
authors.forename: H-T
authors.initials: HT
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, #8 Fengtai dong street, Fengtai District, Beijing, 100071, China. zjuan122@163.com.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, #8 Fengtai dong street, Fengtai District, Beijing, 100071, China. 634436934@qq.com.
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, #8 Fengtai dong street, Fengtai District, Beijing, 100071, China. 46417992@qq.com.
authors.forename: J-L
authors.initials: JL
authors.lastname: Ma
authors.affiliation: Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, #8 Fengtai dong street, Fengtai District, Beijing, 100071, China. tianning331@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Tian
authors.affiliation: Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, #8 Fengtai dong street, Fengtai District, Beijing, 100071, China. 307xxd@163.com.
authors.forename: X-D
authors.initials: XD
authors.lastname: Xing
authors.affiliation: Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, #8 Fengtai dong street, Fengtai District, Beijing, 100071, China. ligj307@sina.com.
authors.forename: G-J
authors.initials: GJ
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D011379:Prognosis; D013997:Time Factors; D036542:Tomography, Spiral Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D003287:Contrast Media
keywords: Dynamic contrast-enhanced computed tomography; Efficacy evaluation; Non-small cell lung cancer; Targeted therapy