title: Boosting brain connectome classification accuracy in Alzheimer's disease using higher-order singular value decomposition.
abstract: Alzheimer's disease (AD) is a progressive brain disease. Accurate detection of AD and its prodromal stage, mild cognitive impairment (MCI), are crucial. There is also a growing interest in identifying brain imaging biomarkers that help to automatically differentiate stages of Alzheimer's disease. Here, we focused on brain structural networks computed from diffusion MRI and proposed a new feature extraction and classification framework based on higher order singular value decomposition and sparse logistic regression. In tests on publicly available data from the Alzheimer's Disease Neuroimaging Initiative, our proposed framework showed promise in detecting brain network differences that help in classifying different stages of Alzheimer's disease.
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California Marina del Rey, CA, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhan
authors.affiliation: School of Computing, Informatics, and Decision Systems Engineering, Arizona State University Tempe, AZ, USA.
authors.forename: Yashu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Computing, Informatics, and Decision Systems Engineering, Arizona State University Tempe, AZ, USA.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Computing, Informatics, and Decision Systems Engineering, Arizona State University Tempe, AZ, USA.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California Marina del Rey, CA, USA.
authors.forename: Neda
authors.initials: N
authors.lastname: Jahanshad
authors.affiliation: Department of Computational Medicine and Bioinformatics, University of Michigan Ann Arbor, MI, USA ; Department of Electrical Engineering and Computer Science, University of Michigan Ann Arbor, MI, USA.
authors.forename: Jieping
authors.initials: J
authors.lastname: Ye
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California Marina del Rey, CA, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
keywords: Alzheimer's disease; classification; connectome; diffusion MRI; high-order SVD; mild cognitive impairment