title: Effectiveness of strabismus surgery on the health-related quality of life assessment of children with intermittent exotropia and their parents: a randomized clinical trial.
abstract: OBJECTIVE
  To evaluate the ability of strabismus surgery to improve the health-related quality of life (HRQOL) assessment scores of children with intermittent exotropia and their parents.
  
  
  METHODS
  For this prospective, randomized, parallel group study, 130 children (8-17 year of age) with intermittent exotropia were recruited and randomized to undergo either corrective strabismus surgery or active monitoring without surgery. Each child was accompanied by a parent. HRQOL was assessed with 3 intermittent exotropia questionnaires (IXTQ)--the child self-report, parental proxy report, and parental self-report--administered at enrollment and 3 months after intervention. The primary outcome was change in IXTQ score after 3 months for both groups.
  
  
  RESULTS
  At enrollment the scores of the surgery group (n = 63) and monitoring group (n = 57) did not differ significantly (P > 0.05). The sex of the reporting parent had no significant influence on the proxy or parental scores at enrollment or at 3 months (P > 0.05, multivariate analysis). Strabismus surgery significantly improved all parts of the IXTQ scores (P < 0.0001, repeated measures analysis of variance). No significant changes were found for the child scores at 3 months in the monitoring group (P = 0.33). However, the parental and proxy scores were significantly decreased (P < 0.0001).
  
  
  CONCLUSIONS
  Corrective strabismus surgery significantly improved the HRQOL scores of the children with intermittent exotropia and their parents.
authors.affiliation: Cancer Research Institute, Central South University, Changsha, Hunan, China; Department of Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xueping
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Manyi
authors.initials: M
authors.lastname: Xiao
authors.affiliation: Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Luosheng
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Jiexi
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China; State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China; Eye Research Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: amyli@csu.edu.cn.
authors.forename: Yunping
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D002648:Child; D005099:Exotropia / Q000523:psychology* / Q000601:surgery*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D009801:Oculomotor Muscles / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures; D010290:Parents; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D015348:Vision, Binocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology