title: Clonal evolution: multiregion sequencing of esophageal adenocarcinoma before and after chemotherapy.
abstract: It is possible to decipher the clonal architecture of a tumor and the sequence in which cancer clones acquire genomic alterations through multiregion sequencing (M-seq). Serial evaluation of tumor specimens through M-seq can provide valuable information on the molecular basis of resistance to therapy.
authors.affiliation: Division of Medical Oncology, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Devarakonda
authors.affiliation: Division of Medical Oncology, Washington University School of Medicine, St. Louis, Missouri. Alvin J. Siteman Cancer Center, St. Louis, Missouri. rgovinda@dom.wustl.edu.
authors.forename: Ramaswamy
authors.initials: R
authors.lastname: Govindan
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D019143:Evolution, Molecular; D015894:Genome, Human; D006801:Humans