title: Sex differences in body fluid homeostasis: Sex chromosome complement influences on bradycardic baroreflex response and sodium depletion induced neural activity.
abstract: Clinical and basic findings indicate that angiotensin II (ANG II) differentially modulates hydroelectrolyte and cardiovascular responses in male and female. But are only the activational and organizational hormonal effects to blame for such differences? Males and females not only differ in their sex (males are born with testes and females with ovaries) but also carry different sex chromosome complements and are thus influenced throughout life by different genomes. In this review, we discuss our recent studies in order to evaluate whether sex chromosome complement is in part responsible for gender differences previously observed in ANG II bradycardic-baroreflex response and sodium depletion-induced sodium appetite and neural activity. To test the hypothesis that XX or XY contributes to the dimorphic ANG II bradycardic-baroreflex response, we used the four core genotype mouse model, in which the effects of gonadal sex (testes or ovaries) and sex chromosome complement (XX or XY) are dissociated. The results indicate that ANG II bradycardic-baroreflex sexual dimorphic response may be ascribed to differences in sex chromosomes, indicating an XX-sex chromosome complement facilitatory bradycardic-baroreflex control of heart rate. Furthermore, we evaluated whether genetic differences within the sex chromosome complement may differentially modulate the known sexually dimorphic sodium appetite as well as basal or induced brain activity due to physiological stimulation of the renin-angiotensin system by furosemide and low-sodium treatment. Our studies demonstrate an organizational hormonal effect on sexually dimorphic induced sodium intake in mice, while at the brain level (subfornical organ and area postrema) we showed a sex chromosome complement effect in sodium-depleted mice, suggesting a sex chromosome gene participation in the modulation of neural pathways underlying regulatory response to renin-angiotensin stimulation.
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC, CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: lvivas@immf.uncor.edu.
authors.forename: L
authors.initials: L
authors.lastname: Vivas
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC, CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: F M
authors.initials: FM
authors.lastname: Dadam
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC, CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: X E
authors.initials: XE
authors.lastname: Caeiro
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D017704:Baroreflex / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D001826:Body Fluids / Q000187:drug effects / Q000502:physiology*; D001919:Bradycardia / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D006706:Homeostasis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D012727:Sex Characteristics; D012730:Sex Chromosomes; D012982:Sodium, Dietary
chemical_list: D012982:Sodium, Dietary; D000804:Angiotensin II
keywords: Angiotensin II; Area postrema; Baroreflex response; FOS-ir; Sex chromosome complement; Sexual dimorphism; Sodium appetite; Subfornical organ