title: Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release.
abstract: Integrating advantages of mitomycin C (MMC)-phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC-phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug-phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Jinyan
authors.initials: J
authors.lastname: Lin
authors.forename: Xiangrui
authors.initials: X
authors.lastname: Yang
authors.forename: Yanxiu
authors.initials: Y
authors.lastname: Li
authors.forename: Shichao
authors.initials: S
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.forename: Shefang
authors.initials: S
authors.lastname: Ye
authors.affiliation: ⊥The First Affiliated Hospital of Xiamen University, Xiamen 361002, China.
authors.forename: Liya
authors.initials: L
authors.lastname: Xie
authors.forename: Lizong
authors.initials: L
authors.lastname: Dai
authors.forename: Zhenqing
authors.initials: Z
authors.lastname: Hou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D065546:Drug Liberation; D005260:Female; D005492:Folic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D006207:Half-Life; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D016685:Mitomycin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D053758:Nanoparticles / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D014018:Tissue Distribution; D014183:Transplantation, Heterologous; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010743:Phospholipids; C552831:poly(ethylene glycol)-folate; D011092:Polyethylene Glycols; D016685:Mitomycin; D005492:Folic Acid
keywords: anticancer-phospholipid complex; nanoparticles; self-assembly; sustained/controlled drug release; targeted drug delivery