title: Dual catalysis for the redox annulation of nitroalkynes with indoles: enantioselective construction of indolin-3-ones bearing quaternary stereocenters.
abstract: The enantioselective redox annulation of nitroalkynes with indoles is enabled by gold/chiral phosphoric acid dual catalysis. A range of indolin-3-one derivatives bearing quaternary stereocenters at the C2 position were afforded in good yields and excellent enantioselectivities (up to 96 % ee) from readily available starting materials.
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014 (China).
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014 (China).
authors.forename: Shi-Chun
authors.initials: SC
authors.lastname: Ye
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014 (China).
authors.forename: Chuan-Jun
authors.initials: CJ
authors.lastname: Lu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014 (China).
authors.forename: Gui-Lin
authors.initials: GL
authors.lastname: Zhuang
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014 (China).
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Gao
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014 (China). yxjia@zjut.edu.cn.
authors.forename: Yi-Xia
authors.initials: YX
authors.lastname: Jia
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D007211:Indoles; C057812:indoline
keywords: asymmetric catalysis; carbenoids; chiral phosphoric acids; gold; indolinones