title: [The newest developments of the study on anti-HIV drugs].
abstract: Besides 36 (28 single-tablets and 8 fixed-dose combinations) used antiretroviral drugs clinically, there are a number of investigational antiretroviral agents currently in phase 2-3 clinical trial. Tenofoviralafenamidefumarate (TAF) is a novel nucleoside analogue reverse transcriptase inhibitor that is potent and less toxicity than tenofovir (TDF). Doravirine is a non-nucleoside analogue reverse transcriptase inhibitor that demonstrates activity against NNRTI-resistant viral strains. GSK744 is an integrase inhibitor with a long acting preparation. In addition, several drugs with new mechanisms are also noted, for example, BMS-663 068 is a small molecule CD4 attachment inhibitors and cenicriviroc is a novel CCR5/CCR2 antagonist with antiretroviral activity and anti-inflammatory effects. Several drug classes that target known pathways in HIV latency have being developed, and leading the list are histone deacetylase inhibitors. Other agents include protein kinase C activators, positive transcription elongation factor activators, DNA methyl-transferase inhibitors and histone methyl-transferase inhibitors and so on. This review is focused on the above-mentioned drug candidates that may be used in clinical in next couple of years and those compounds that can reverse latent HIV infections.
authors.forename: Xing-quan
authors.initials: XQ
authors.lastname: Zhang
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D010755:Organophosphates / Q000627:therapeutic use; D063065:Organophosphonates / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D011728:Pyridones / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D000068698:Tenofovir; D054659:Diketopiperazines
chemical_list: D000225:Adenine; D019380:Anti-HIV Agents; D010755:Organophosphates; D063065:Organophosphonates; D010879:Piperazines; D011728:Pyridones; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; C576364:fostemsavir; C584914:cabotegravir; D054659:Diketopiperazines