title: An asymmetric alkynylation/hydrothiolation cascade: an enantioselective synthesis of thiazolidine-2-imines from imines, acetylenes and isothiocyanates.
abstract: A multicomponent reaction between imines, terminal alkynes, and isothiocyanates in the presence of a catalytic chiral copper-pybox complex proceeds enantioselectively to give enantiopure thiazolidine-2-imines (60-99% ee) via a highly regioselective intramolecular 5-exo-dig hydrothiolation reaction.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kanpur-208016, Uttar Pradesh, India. ddethe@iitk.ac.in.
authors.forename: Alok
authors.initials: A
authors.lastname: Ranjan
authors.forename: Anupam
authors.initials: A
authors.lastname: Mandal
authors.forename: Swapnil G
authors.initials: SG
authors.lastname: Yerande
authors.forename: Dattatraya H
authors.initials: DH
authors.lastname: Dethe
mesh_terms: D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D007097:Imines; D017879:Isothiocyanates; D053778:Thiazolidines