title: Neuroplasticity in Human Alcoholism: Studies of Extended Abstinence with Potential Treatment Implications.
abstract: Alcoholism is characterized by a lack of control over excessive alcohol consumption despite significant negative consequences. This impulsive and compulsive behavior may be related to functional abnormalities within networks of brain regions responsible for how we make decisions. The abnormalities may result in strengthened networks related to appetitive drive-or the need to fulfill desires-and simultaneously weakened networks that exercise control over behaviors. Studies using functional magnetic resonance imaging (fMRI) in abstinent alcoholics suggest that abstinence is associated with changes in the tone of such networks, decreasing resting tone in appetitive drive networks, and increasing resting tone in inhibitory control networks to support continued abstinence. Identifying electroencephalographic (EEG) measures of resting tone in these networks initially identified using fMRI, and establishing in longitudinal studies that these abstinence-related changes in network tone are progressive would motivate treatment initiatives to facilitate these changes in network tone, thereby supporting successful ongoing abstinence.
authors.affiliation: Neurobehavioral Research, Inc., Honolulu, Hawaii.
authors.forename: George
authors.initials: G
authors.lastname: Fein
authors.affiliation: Neurobehavioral Research, Inc., Honolulu, Hawaii.
authors.forename: Valerie A
authors.initials: VA
authors.lastname: Cardenas
mesh_terms: D000437:Alcoholism / Q000503:physiopathology*; D001070:Appetitive Behavior / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D004328:Drive; D056344:Executive Function / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000503:physiopathology*; D009473:Neuronal Plasticity / Q000502:physiology*