title: Nanofibers Fabricated Using Triaxial Electrospinning as Zero Order Drug Delivery Systems.
abstract: A new strategy for creating functional trilayer nanofibers through triaxial electrospinning is demonstrated. Ethyl cellulose (EC) was used as the filament-forming matrix in the outer, middle, and inner working solutions and was combined with varied contents of the model active ingredient ketoprofen (KET) in the three fluids. Triaxial electrospinning was successfully carried out to generate medicated nanofibers. The resultant nanofibers had diameters of 0.74 ± 0.06 μm, linear morphologies, smooth surfaces, and clear trilayer nanostructures. The KET concentration in each layer gradually increased from the outer to the inner layer. In vitro dissolution tests demonstrated that the nanofibers could provide linear release of KET over 20 h. The protocol reported in this study thus provides a facile approach to creating functional nanofibers with sophisticated structural features.
authors.affiliation: School of Materials Science & Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Yangpu District, Shanghai 200093, China.
authors.forename: Deng-Guang
authors.initials: DG
authors.lastname: Yu
authors.affiliation: School of Materials Science & Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Yangpu District, Shanghai 200093, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Li
authors.affiliation: School of Materials Science & Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Yangpu District, Shanghai 200093, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Materials Science & Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Yangpu District, Shanghai 200093, China.
authors.forename: Jun-He
authors.initials: JH
authors.lastname: Yang
authors.affiliation: Faculty of Science and Technology, University of Westminster , 115 New Cavendish Street, London W1W 6UW, U.K.
authors.forename: S W Annie
authors.initials: SW
authors.lastname: Bligh
authors.affiliation: UCL School of Pharmacy, University College London , 29-39 Brunswick Square, London WC1N 1AX, U.K.
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Williams
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000378:metabolism; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D007660:Ketoprofen / Q000737:chemistry / Q000378:metabolism; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; C013517:ethyl cellulose; D002482:Cellulose; D007660:Ketoprofen
keywords: gradient distribution; medicated nanofibers; triaxial electrospinning; trilayer structure; zero-order controlled release