title: High-dose versus conventional-dose irradiation in cisplatin-based definitive concurrent chemoradiotherapy for esophageal cancer: a systematic review and pooled analysis.
abstract: We investigate whether high-dose (HD, ≥60 Gy) radiotherapy in definitive concurrent chemoradiotherapy (CCRT) based on cisplatin could yield benefits compared to conventional-dose (CD) CCRT. PubMed, Embase and Google Scholar were searched and data were pooled and analyzed for response rate, survival, failure patterns and toxicity. Results showed advantages in response rate, 5-year overall survival rate, local regional recurrence and distant failure rate compared to the CD arm with no difference in Grade ≥3 acute and late esophagitis, other toxicities were rare with moderate tolerance, subgroup analysis of squamous cell carcinoma also showed advantages for HD arm. We concluded that ≥60 Gy CCRT improved clinical outcomes compared to the CD arm, especially for esophageal squamous cell carcinoma. Our findings may provide a basis for future trials.
authors.affiliation: a Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, Zhejiang, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.affiliation: a Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, Zhejiang, PR China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Liang
authors.affiliation: a Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, Zhejiang, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Fang
authors.forename: Shixiu
authors.initials: S
authors.lastname: Wu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D000077277:Esophageal Squamous Cell Carcinoma; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011879:Radiotherapy Dosage; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: chemotherapy; concurrent chemoradiotherapy; conventional-dose; esophageal cancer; esophageal squamous cell carcinoma; high-dose; radiation dose; radiotherapy