title: Drug release behavior of poly (lactic-glycolic acid) grafting from sodium alginate (ALG-g-PLGA) prepared by direct polycondensation.
abstract: Hydrophobically modified sodium alginate, poly (lactic-glycolic acid) grafting from sodium alginate (ALG-g-PLGA), was successfully synthesized through direct one-step polymerization of sodium alginate, glycolic acid, and lactic acid. ALG-g-PLGA self-assembled to colloidal nanoparticles and subsequently hydrogel microspheres were obtained by crosslinking ALG-g-PLGA nanoparticles in the solution of calcium chloride. The modified hydrogel microspheres could be used as the drug delivery vehicles for a hydrophobic ibuprofen. Compared with sodium alginate, ALG-g-PLGA demonstrated an improved drug loading rate, encapsulation efficiency, and prolonged release speed. The products, as novel and highly promising biomaterials, have potential applications.
authors.affiliation: a The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , Jiangsu Province , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Shi
authors.affiliation: a The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , Jiangsu Province , China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Ding
authors.affiliation: a The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , Jiangsu Province , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: a The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , Jiangsu Province , China.
authors.forename: Luyan
authors.initials: L
authors.lastname: Wu
authors.affiliation: a The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , Jiangsu Province , China.
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.affiliation: a The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , Jiangsu Province , China.
authors.forename: Caihua
authors.initials: C
authors.lastname: Ni
mesh_terms: D000464:Alginates / Q000737:chemistry* / Q000648:ultrastructure; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry; D003102:Colloids; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D004355:Drug Stability; D006358:Hot Temperature / Q000009:adverse effects; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007052:Ibuprofen / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D007202:Indicators and Reagents; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013499:Surface Properties
chemical_list: D000464:Alginates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003102:Colloids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D007202:Indicators and Reagents; D011091:Polyesters; C000608787:alginate-g-poly(lactic-glycolic acid); D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002122:Calcium Chloride; D007052:Ibuprofen
keywords: direct polycondensation; drug carrier; hydrophobic modification; sodium alginate