title: Translational Control of the HIV Unspliced Genomic RNA.
abstract: Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.
authors.affiliation: Molecular and Cellular Virology Laboratory, Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 834100, Santiago, Chile. barbara.rojas.araya@gmail.com.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Rojas-Araya
authors.affiliation: CIRI, International Center for Infectiology Research, Université de Lyon, Lyon 69007, France. tohlmann@ens-lyon.fr.|Inserm, U1111, Lyon 69007, France. tohlmann@ens-lyon.fr.|Ecole Normale Supérieure de Lyon, Lyon 69007, France. tohlmann@ens-lyon.fr.|Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon 69007, France. tohlmann@ens-lyon.fr.|CNRS, UMR5308, Lyon 69007, France. tohlmann@ens-lyon.fr.
authors.forename: Théophile
authors.initials: T
authors.lastname: Ohlmann
authors.affiliation: Molecular and Cellular Virology Laboratory, Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 834100, Santiago, Chile. barbara.rojas.araya@gmail.com.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Soto-Rifo
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D015498:HIV-2 / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D012261:Ribonucleoproteins; D014764:Viral Proteins
keywords: DDX3; HIV-1; IRES; Rev; cap-dependent translation; nuclear export