title: Cytotoxic Biscembranoids from the Soft Coral Sarcophyton pauciplicatum.
abstract: Ten biscembranoids (1-10), including the two new compounds sarcophytolides M and N (1 and 2), were isolated from the methanol extract of the Vietnamese soft coral Sarcophyton pauciplicatum. Their structures were elucidated by spectroscopic methods including one dimensional (1D)- and 2D-NMR, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and circular dichroism (CD). The in vitro cytotoxic activity of all isolated compounds against a panel of eight human cancer cell lines including HepG2 (hepatoma cancer), HL-60 (acute leukemia), KB (epidermoid carcinoma), LNCaP (prostate cancer), LU-1 (lung cancer), MCF7 (breast cancer), SK-Mel2 (melanoma), and SW480 (colon adenocarcinoma) was evaluated using the sulforhodamine B colorimetric assay. Among the isolated biscembranoids, 1, 3, 4, 7, 9, and 10 exhibited significant cytotoxic effects and may be selected for further studies of their anticancer activity.
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Nguyen Hoai
authors.initials: NH
authors.lastname: Nam
authors.forename: Pham The
authors.initials: PT
authors.lastname: Tung
authors.forename: Ninh Thi
authors.initials: NT
authors.lastname: Ngoc
authors.forename: Tran Thi Hong
authors.initials: TT
authors.lastname: Hanh
authors.forename: Nguyen Phuong
authors.initials: NP
authors.lastname: Thao
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Thanh
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.forename: Do Thi
authors.initials: do T
authors.lastname: Thao
authors.forename: Tran Thu
authors.initials: TT
authors.lastname: Huong
authors.forename: Do Cong
authors.initials: do C
authors.lastname: Thung
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D021241:Spectrometry, Mass, Electrospray Ionization; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D004224:Diterpenes; D013729:Terpenes; C117040:sarcophytolide