title: The diverse roles of adiponectin in non-small-cell lung cancer: current data and future perspectives.
abstract: In recent years, there is growing research interest for the biological role of adipose tissue-derived bioactive factors, mainly including adipokines, in various forms of cancer. Adiponectin (APN) is the most abundant circulating adipokine, and a key mediator of several cancer-related processes, such as cell proliferation, apoptosis, regulation of tumor cell invasion and angiogenesis. In this review we summarize and critically discuss the published literature on the diverse roles of APN in non-small-cell lung cancer, including its implication in lung cancer development, its use as a diagnostic and prognostic biomarker, and its correlation with cancer-related cachexia. The main challenges and future perspectives, mainly with regard to the potential development of APN-targeted therapeutic agents in cancer therapeutics, are also briefly presented and discussed.
authors.affiliation: Oncology Unit GPP, 'Sotiria' General Hospital, Athens School of Medicine, Mesogion 152, 11527, Athens, Greece.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Boura
authors.affiliation: Oncology Unit GPP, 'Sotiria' General Hospital, Athens School of Medicine, Mesogion 152, 11527, Athens, Greece.
authors.forename: Stylianos
authors.initials: S
authors.lastname: Loukides
authors.affiliation: Oncology Unit GPP, 'Sotiria' General Hospital, Athens School of Medicine, Mesogion 152, 11527, Athens, Greece.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Grapsa
authors.affiliation: Oncology Unit GPP, 'Sotiria' General Hospital, Athens School of Medicine, Mesogion 152, 11527, Athens, Greece.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Achimastos
authors.affiliation: Oncology Unit GPP, 'Sotiria' General Hospital, Athens School of Medicine, Mesogion 152, 11527, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Syrigos
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000273:Adipose Tissue / Q000473:pathology; D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D002100:Cachexia / Q000150:complications / Q000235:genetics / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000235:genetics* / Q000473:pathology; D049109:Cell Proliferation / Q000235:genetics; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000473:pathology
chemical_list: D052242:Adiponectin; D014408:Biomarkers, Tumor
keywords: adipokines; adiponectin; adipose tissue; cancer cachexia; non-small-cell lung cancer