title: Regioselective, Molecular Iodine-Mediated C3 Iodination of Quinolines.
abstract: A novel and convenient method has been developed for the regioselective iodination of quinolines at their C3 position under metal-free conditions. Iodinated quinolines, which are popular building blocks in organic and medicinal chemistry, can be prepared in gram quantities and good yields using this method and further derivatized to give increasingly complex compounds. Preliminary mechanistic studies have shown that this reaction most likely occurs via a radical intermediate.
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Yunhe
authors.initials: Y
authors.lastname: Lv
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Sun
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Mingyang
authors.initials: M
authors.lastname: Jia
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Zhenduo
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006847:Hydrocarbons, Iodinated; D011804:Quinolines; D007455:Iodine