title: Biochemical Responses of Anodized Titanium Implants with a Poly(lactide-co-glycolide)/Bone Morphogenetic Protein-2 Submicron Particle Coating. Part 2: An In Vivo Study.
abstract: OBJECTIVE
  A biochemical approach to implant surfaces can improve bone growth, resulting in desirable bone-implant interfaces. This study was conducted to identify the effect on osseointegration of direct coating of titanium (Ti) implants with poly(D,L-lactide-co-glycolide)(PLGA)/recombinant human bone morphogenetic 2 (rhBMP-2) submicron particles by electrospray.
  
  
  METHODS
  Anodized Ti implants were used as a control group, and implants coated with 80 μL of PLGA/rhBMP-2 (50 μg/mL rhBMP-2 per implant) submicron particles by electrospray were used as the experimental group in an in vivo rabbit tibia model. After 3 or 7 weeks of healing, specimens were obtained and prepared for histologic and histomorphometric analyses.
  
  
  RESULTS
  The implant surface coated with submicron PLGA/rhBMP-2 showed new bone growth in the apical direction earlier than control implants. In the experimental group at 3 weeks, the bone-to-implant contact ratio and bone area of the three best consecutive threads were significantly higher than those in the control group. However, there was no significant difference between groups at 7 weeks.
  
  
  CONCLUSIONS
  Within the limitations of this study, the PLGA/rhBMP-2-coated implants facilitated osseointegration between bone and the Ti surface during the early healing phase.
authors.forename: Soo-Yeon
authors.initials: SY
authors.lastname: Yoo
authors.forename: Seong-Kyun
authors.initials: SK
authors.lastname: Kim
authors.forename: Seong-Joo
authors.initials: SJ
authors.lastname: Heo
authors.forename: Jai-Young
authors.initials: JY
authors.lastname: Koak
authors.forename: Joo-Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Ji-Man
authors.initials: JM
authors.lastname: Heo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D055396:Bone Morphogenetic Protein 2 / Q000032:analysis / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D015921:Dental Implants; D004195:Disease Models, Animal; D006801:Humans; D020007:Implants, Experimental; D019344:Lactic Acid; D016348:Osseointegration / Q000187:drug effects* / Q000502:physiology; D011098:Polyglactin 910 / Q000737:chemistry*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000187:drug effects / Q000601:surgery; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011098:Polyglactin 910; D014025:Titanium