title: Molecular epidemiology of coxsackievirus type B1.
abstract: Coxsackievirus type B1 (CVB1) has emerged globally as the predominant enterovirus serotype and is associated with epidemics of meningitis and chronic diseases. In this report, the phylogeny of CVB1 was studied based on the VP1 sequences of 11 North African isolates and 81 published sequences. All CVB1 isolates segregated into four distinct genogroups and 10 genotypes. Most of the identified genotypes of circulating CVB1 strains appear to have a strict geographical specificity. The North African strains were of a single genotype and probably evolved distinctly. Using a relaxed molecular clock model and three different population models (constant population, exponential growth and Bayesian skyline demographic models) in coalescent analysis using the BEAST program, the substitution rate in CVB1 varied between 6.95 × 10(-3) and 7.37 × 10(-3) substitutions/site/year in the VP1 region. This study permits better identification of circulating CVB1, which has become one of the most predominant enterovirus serotypes in humans.
authors.affiliation: Faculty of Sciences of Bizerte, University of Carthage, Avenue de la République, Amilcar, BP77, 1054, Tunis, Tunisia.
authors.forename: Ichrak
authors.initials: I
authors.lastname: Abdelkhalek
authors.affiliation: Laboratory of Enteroviruses, Institut Pasteur of Algeria, Route de petit Staouéli, Dely Ibrahim, Algeria.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Seghier
authors.affiliation: Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis, 13, Place Pasteur, BP74, 1002, Tunis-Belvédère, Tunisia.|University of Tunis El Manar, Campus universitaire Farhat Hached, Poste Romena, BP94, 1068, Tunis, Tunisia.
authors.forename: Ahlem Ben
authors.initials: AB
authors.lastname: Yahia
authors.affiliation: Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis, 13, Place Pasteur, BP74, 1002, Tunis-Belvédère, Tunisia.|University of Tunis El Manar, Campus universitaire Farhat Hached, Poste Romena, BP94, 1068, Tunis, Tunisia.
authors.forename: Henda
authors.initials: H
authors.lastname: Touzi
authors.affiliation: Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis, 13, Place Pasteur, BP74, 1002, Tunis-Belvédère, Tunisia.|University of Tunis El Manar, Campus universitaire Farhat Hached, Poste Romena, BP94, 1068, Tunis, Tunisia.
authors.forename: Zina
authors.initials: Z
authors.lastname: Meddeb
authors.affiliation: Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis, 13, Place Pasteur, BP74, 1002, Tunis-Belvédère, Tunisia.|University of Tunis El Manar, Campus universitaire Farhat Hached, Poste Romena, BP94, 1068, Tunis, Tunisia.
authors.forename: Henda
authors.initials: H
authors.lastname: Triki
authors.affiliation: Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis, 13, Place Pasteur, BP74, 1002, Tunis-Belvédère, Tunisia. dor_rare@yahoo.fr.|University of Tunis El Manar, Campus universitaire Farhat Hached, Poste Romena, BP94, 1068, Tunis, Tunisia. dor_rare@yahoo.fr.
authors.forename: Dorra
authors.initials: D
authors.lastname: Rezig
mesh_terms: D000352:Africa, Northern / Q000453:epidemiology; D001483:Base Sequence; D003384:Coxsackievirus Infections / Q000453:epidemiology / Q000821:virology*; D029822:Enterovirus B, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins
keywords: Coxsackievirus type B1; Enteroviruses; Phylogeny; VP1 gene