title: C1-Benzyl and benzoyl isoquinoline synthesis through direct oxidative cross-dehydrogenative coupling with methyl arenes.
abstract: An oxidative cross-dehydrogenative coupling (CDC) of isoquinolines with methyl arenes has been developed, allowing for the facile synthesis of a broad range of structurally diverse C1-benzyl and -benzoyl isoquinolines. The direct use of readily available methyl arenes as coupling partners avoids unproductive steps for preactivating the functional group installation, and is therefore attractive. The method exhibits excellent chemoselectivity, affording exclusive benzylated products in the presence of DTBP and a catalytic amount of Y(OTf)3, and yielding benzoylated ones with TBHP and a catalytic amount of MnO2.
authors.affiliation: Key Lab of Chemical Biology of Education Ministry, School of Pharmaceutical Sciences, Jinan 250012, China. leiliu@sdu.edu.cn.
authors.forename: Miao
authors.initials: M
authors.lastname: Wan
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D007546:Isoquinolines / Q000737:chemistry*; D058451:Oxidative Coupling; D010545:Peroxides / Q000737:chemistry; D020122:tert-Butylhydroperoxide / Q000737:chemistry
chemical_list: D007546:Isoquinolines; D010545:Peroxides; C111570:di-tert-butyl peroxide; D020122:tert-Butylhydroperoxide; C039109:isoquinoline