title: Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1.
abstract: Five new compounds, pinazaphilones A and B (1, 2), two phenolic compounds (4, 5), and penicidone D (6), together with the known Sch 1385568 (3), (±)-penifupyrone (7), 3-O-methylfunicone (8), 5-methylbenzene-1,3-diol (9), and 2,4-dihydroxy-6-methylbenzoic acid (10) were obtained from the culture of the endophytic fungus Penicillium sp. HN29-3B1, which was isolated from a fresh branch of the mangrove plant Cerbera manghas collected from the South China Sea. Their structures were determined by analysis of 1D and 2D NMR and mass spectroscopic data. Structures of compounds 4 and 7 were further confirmed by a single-crystal X-ray diffraction experiment using Cu Kα radiation. The absolute configurations of compounds 1-3 were assigned by quantum chemical calculations of the electronic circular dichroic spectra. Compounds 2, 3, 5, and 7 inhibited α-glucosidase with IC50 values of 28.0, 16.6, 2.2, and 14.4 μM, respectively, and are thus more potent than the positive control, acarbose.
authors.forename: Yayue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Chinese Center for Chirality, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Hebei University , Baoding, 071002, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Guoping
authors.initials: G
authors.lastname: Xia
authors.forename: Hongbo
authors.initials: H
authors.lastname: Huang
authors.forename: Hanxiang
authors.initials: H
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Lu
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences , Jinan 250014, People's Republic of China.
authors.forename: Xuekui
authors.initials: X
authors.lastname: Xia
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
mesh_terms: D001578:Benzopyrans / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D043982:Rhizophoraceae / Q000382:microbiology; D000520:alpha-Glucosidases / Q000187:drug effects
chemical_list: D001578:Benzopyrans; D004365:Drugs, Chinese Herbal; D065089:Glycoside Hydrolase Inhibitors; D061065:Polyketides; C544347:Sch 1385568; D000520:alpha-Glucosidases