title: Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells.
abstract: Peripheral blood mononuclear cells (PBMC) were donated by a patient with clinically diagnosed frontotemporal dementia (FTD). Induced pluripotent stem cells (iPSCs) were developed using integration-free CytoTune-iPS Sendai Reprogramming factors which include Sendai virus particles of the four Yamanaka factors Oct, Sox2, Klf4, and c-Myc.
authors.affiliation: Department of Neurology, Rhode Island Hospital and Brown University Warren Alpert Medical School, Providence, RI, United States; Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States.
authors.forename: Han-Kyu
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States.
authors.forename: Peter
authors.initials: P
authors.lastname: Morin
authors.affiliation: Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States.
authors.forename: John
authors.initials: J
authors.lastname: Wells
authors.affiliation: Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States; Medical Research & Development Service, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States.
authors.forename: Eugene B
authors.initials: EB
authors.lastname: Hanlon
authors.affiliation: Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States. Electronic address: weiming.xia@va.gov.
authors.forename: Weiming
authors.initials: W
authors.lastname: Xia
mesh_terms: D002454:Cell Differentiation; D065150:Cellular Reprogramming; D057180:Frontotemporal Dementia / Q000378:metabolism / Q000473:pathology*; D005822:Genetic Vectors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism*; D007621:Karyotyping; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000166:cytology*; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D055748:SOXB1 Transcription Factors / Q000235:genetics
chemical_list: C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; D050814:Octamer Transcription Factor-3; D016271:Proto-Oncogene Proteins c-myc; D055748:SOXB1 Transcription Factors