title: Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function.
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Perner
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: T M
authors.initials: TM
authors.lastname: Schnöder
authors.affiliation: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Ranjan
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Wolleschak
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Ebert
authors.affiliation: Mouse-Pathology, Animal Experimental Unit, Helmholtz-Center for Infection Research (HZI), Braunschweig, Germany.
authors.forename: M C
authors.initials: MC
authors.lastname: Pils
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Frey
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Polanetzki
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Fahldieck
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Schönborn
authors.affiliation: Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.|Department of Immune Control, Helmholtz-Center for Infection Research (HZI), Braunschweig, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Schraven
authors.affiliation: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Isermann
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Fischer
authors.affiliation: Department of Hematology and Oncology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: F H
authors.initials: FH
authors.lastname: Heidel
mesh_terms: D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D002478:Cells, Cultured; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D053612:Janus Kinases / Q000037:antagonists & inhibitors*; D051379:Mice; D008807:Mice, Inbred BALB C; D009196:Myeloproliferative Disorders / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000473:pathology
chemical_list: D001549:Benzamides; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; C546012:N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide; D053612:Janus Kinases