title: The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats.
abstract: Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature.
  
  
  OBJECTIVE
  This study investigates the effect of etoricoxib on oxidative stress induced by I/R of the rat liver.
  
  
  METHODS
  Experimental animals were divided into four groups as liver I/R control (LIRC), 50 mg/kg etoricoxib + liver I/R (ETO-50), 100 mg/kg etoricoxib + liver I/R (ETO-100), and healthy group (HG). ETO-50 and ETO-100 groups were administered etoricoxib, while LIRC and HG groups were orally given distilled water by gavage. Hepatic artery was clamped for one hour to provide ischemia, and then reperfusion was provided for 6 hours. Oxidant, antioxidant, and COX-2 gene expressions were studied in the liver tissues. ALT and AST were measured.
  
  
  RESULTS
  Etoricoxib in 50 and 100 mg/kg doses changed the levels of oxidant/antioxidant parameters such as MDA, MPO, tGSH, GSHRd, GST, SOD, NO, and 8-OH/Gua in favour of antioxidants. Furthermore, etoricoxib prevented increase of COX-2 gene expression and ALT and AST levels. This important protective effect of etoricoxib on the rat liver I/R can be tested in the clinical setting.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Ordu University, Ordu, Turkey.
authors.forename: Celalettin Semih
authors.initials: CS
authors.lastname: Kunak
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Kukula
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Ordu University, Ordu, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Mutlu
authors.affiliation: Department of Pharmacology Nursery, Faculty of Health Science, Giresun University, Giresun, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Genç
authors.affiliation: Department of Medical Device and Drug Institute, Turkish Health Ministry, Ankara, Turkey.
authors.forename: Gülçer Güleç
authors.initials: GG
authors.lastname: Peker
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan University, 24030 Erzincan, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Kuyrukluyıldız
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan University, 24030 Erzincan, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Binici
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030 Erzincan, Turkey.
authors.forename: Durdu
authors.initials: D
authors.lastname: Altuner
authors.affiliation: Department of Biochemistry, Faculty of Medicine, 100 Yıl University, Van, Turkey.
authors.forename: Hamit Hakan
authors.initials: HH
authors.lastname: Alp
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D000077613:Etoricoxib; D005786:Gene Expression Regulation / Q000187:drug effects; D005978:Glutathione / Q000032:analysis; D005980:Glutathione Reductase / Q000032:analysis; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects*; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D013450:Sulfones / Q000008:administration & dosage / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000032:analysis
chemical_list: D000975:Antioxidants; D052246:Cyclooxygenase 2 Inhibitors; D011725:Pyridines; D013450:Sulfones; D008315:Malondialdehyde; D004247:DNA; D051546:Cyclooxygenase 2; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D000077613:Etoricoxib