title: Interaction Fingerprints and Their Applications to Identify Hot Spots.
abstract: Binding recognition is in the core of how nature controls processes in living cells, how enzyme-substrate binding leads to catalysis and how drugs modulate enzymes and receptors to convey a desirable physiological response. Thus, understanding binding recognition in a systematic manner is paramount, not only to understand biological processes but also to be able to design and discover new bioactive compounds. One such way to analyze binding interactions is through the development of binding interaction fingerprints. Here, we present the methodology to develop interaction fingerprints with three different software platforms along with two representative examples.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Mexico City, 04510, Mexico.
authors.forename: Andrés F
authors.initials: AF
authors.lastname: Marmolejo
authors.forename: José L
authors.initials: JL
authors.lastname: Medina-Franco
authors.forename: Marc
authors.initials: M
authors.lastname: Giulianotti
authors.forename: Karina
authors.initials: K
authors.lastname: Martinez-Mayorga
mesh_terms: D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism; D025941:Protein Interaction Mapping / Q000379:methods*; D060066:Protein Interaction Maps; D011957:Receptors, Opioid / Q000378:metabolism
chemical_list: D011957:Receptors, Opioid; D051357:Cyclin-Dependent Kinase 2