title: Automatic Segmentation of Spinal Canals in CT Images via Iterative Topology Refinement.
abstract: Accurate segmentation of the spinal canals in computed tomography (CT) images is an important task in many related studies. In this paper, we propose an automatic segmentation method and apply it to our highly challenging image cohort that is acquired from multiple clinical sites and from the CT channel of the PET-CT scans. To this end, we adapt the interactive random-walk solvers to be a fully automatic cascaded pipeline. The automatic segmentation pipeline is initialized with robust voxelwise classification using Haar-like features and probabilistic boosting tree. Then, the topology of the spinal canal is extracted from the tentative segmentation and further refined for the subsequent random-walk solver. In particular, the refined topology leads to improved seeding voxels or boundary conditions, which allow the subsequent random-walk solver to improve the segmentation result. Therefore, by iteratively refining the spinal canal topology and cascading the random-walk solvers, satisfactory segmentation results can be acquired within only a few iterations, even for cases with scoliosis, bone fractures and lesions. Our experiments validate the capability of the proposed method with promising segmentation performance, even though the resolution and the contrast of our dataset with 110 patient cases (90 for testing and 20 for training) are low and various bone pathologies occur frequently.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Le
authors.initials: L
authors.lastname: Lu
authors.forename: Dijia
authors.initials: D
authors.lastname: Wu
authors.forename: Noha
authors.initials: N
authors.lastname: El-Zehiry
authors.forename: Yefeng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D016208:Databases, Factual; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D013115:Spinal Canal / Q000000981:diagnostic imaging*; D016103:Spinal Fractures / Q000000981:diagnostic imaging; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging; D013499:Surface Properties; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult