title: Primary intraocular synovial sarcoma in the post retinal detachment operative state.
abstract: Synovial sarcoma generally arises in the deep soft tissue, although it has been described at virtually every anatomic site except in the eyeball. We report the case of a 48-year-old woman who had a history of retinal detachment surgery and who had undergone vitrectomy and the insertion of a solid silicon explant 24 years previously. She reported a visual field defect. Funduscopy and MRI revealed a tumour just behind the iris in the left eyeball, and enucleation was performed. Microscopic examination of the tumour revealed uniform spindle cells in a fascicular arrangement with frequent mitotic figures. Immunohistochemistry showed that the tumour was positive for TLE1 and epithelial membrane antigen and fluorescent in situ hybridisation revealed that the tumour had a rearrangement of the SYT gene. Reverse transcription (RT)-PCR confirmed the presence of a SYT-SSX2 fusion transcript. On the basis of these histomorphological and molecular features, the diagnosis of poorly differentiated synovial sarcoma was rendered.
authors.affiliation: Department of Pathology, National Cancer Center Hospital, Tokyo, Chuou, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Ito
authors.affiliation: Department of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo, Chuou, Japan.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Pathology, National Cancer Center Hospital, Tokyo, Chuou, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Department of Pathology, National Cancer Center Hospital, Tokyo, Chuou, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Mori
mesh_terms: D056970:Co-Repressor Proteins; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012163:Retinal Detachment / Q000473:pathology* / Q000601:surgery; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D056970:Co-Repressor Proteins; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C093961:SS18 protein, human; C499043:TLE1 protein, human; C093962:synovial sarcoma X breakpoint proteins