title: Recombinant Newcastle disease virus-vectored vaccines against human and animal infectious diseases.
abstract: Recent advances in recombinant genetic engineering techniques have brought forward a leap in designing new vaccines in modern medicine. One attractive strategy is the application of reverse genetics technology to make recombinant Newcastle disease virus (rNDV) deliver protective antigens of pathogens. In recent years, numerous studies have demonstrated that rNDV-vectored vaccines can induce quicker and better humoral and mucosal immune responses than conventional vaccines and are protective against pathogen challenges. With deeper understanding of NDV molecular biology, it is feasible to develop gene-modified rNDV vaccines accompanied by good safety, high efficacy, low toxicity and better immunogenicity. This review summarizes the development of reverse genetics technology in using NDV as a promising vaccine vector to design new vaccines for human and animal use.
authors.affiliation: College of Animal Science, Guizhou University, Guiyang 550025, Guizhou, China.|Key Laboratory of Animal Genetics, Breeding & Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang 550025, Guizhou, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Duan
authors.affiliation: College of Animal Science, Guizhou University, Guiyang 550025, Guizhou, China.|Key Laboratory of Animal Genetics, Breeding & Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang 550025, Guizhou, China.
authors.forename: Houqiang
authors.initials: H
authors.lastname: Xu
authors.affiliation: College of Animal Science, Guizhou University, Guiyang 550025, Guizhou, China.
authors.forename: Xinqin
authors.initials: X
authors.lastname: Ji
authors.affiliation: College of Animal Science, Guizhou University, Guiyang 550025, Guizhou, China.|Key Laboratory of Animal Genetics, Breeding & Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang 550025, Guizhou, China.
authors.forename: Jiafu
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000818:Animals; D003140:Communicable Disease Control / Q000379:methods; D005818:Genetic Engineering; D005822:Genetic Vectors; D016679:Genome, Viral; D006801:Humans; D056724:Immunity, Humoral; D018928:Immunity, Mucosal; D009522:Newcastle disease virus / Q000235:genetics* / Q000276:immunology*; D059386:Reverse Genetics; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D014614:Vaccines, Synthetic; D014765:Viral Vaccines
keywords: Newcastle disease virus; protective immune response; reverse genetics technology; vaccine development; virus-vectored vaccine