title: The Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats.
abstract: Osteoporosis is a disease characterized by low bone mass and progressive destruction of bone microstructure, resulting in increased the risk of fracture. Previous studies have demonstrated the effect of naringin (NG) or treadmill exercise (EX) on osteoporosis, however, reports about effects of NG plus EX on osteoporosis are limited. This study was designed to investigate the impact of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized (OVX) rats. Three months after bilateral ovariectomy, Seventy-five rats were randomly assigned to the following treatment groups: OVX, sham-operated (SHAM), NG, EX, or NG plus EX treatment. Treatments were administered for 60 days. Bone metabolism, bone mineral density, trabecular bone parameters, immunohistochemistry, and the bone strength were evaluated. Compared to the OVX groups, all treatments increased bone volume (BV/TV), trabecula number (Tb.N), trabecula thickness (Tb.Th), bone mineral density (BMD), and mechanical strength. NG + EX showed the strongest effects on BV/TV, Tb.Th, and biomechanical strength. Additionally, decreased C-terminal telopeptides of type I collagen (CTX-1) and enhanced osteocalcin (OCN) expression were observed in the NG + EX group. The present study demonstrates that the NG + EX may have a therapeutic advantage over each monotherapy for the treatment of osteoporosis.
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Sun
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Fengbo
authors.initials: F
authors.lastname: Li
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Xinlong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Ma
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Lv
authors.affiliation: Orthopedics Department, Tianjin Hospital, NO.122 Munan Road Heping District, Tianjin 300050, China.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Meng
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D005260:Female; D044950:Flavanones / Q000008:administration & dosage*; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy* / Q000473:pathology; D010052:Ovariectomy; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D044950:Flavanones; C005274:naringin