title: Triboelectrification of active pharmaceutical ingredients: week acids and their salts.
abstract: The effect of salt formulation on the electrostatic property of active pharmaceutical ingredients was investigated. The electrostatic property of weak acids (carboxylic acids and amide-enole type acid) and their sodium salts was evaluated by a suction-type Faraday cage meter. Free carboxylic acids showed negative chargeability, whereas their sodium salts showed more positive chargeability than the free acids. However, no such trend was observed for amide-enole type acids.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan; Generic Pharmaceutical Development Department, Nippon Chemiphar Co., Ltd., 1-22, Hikokawado, Misato, Saitama 341-0005, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Fujinuma
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishii
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yashihashi
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41, Ebara, Shinagawa, Tokyo 142-8501, Japan.
authors.forename: Estuo
authors.initials: E
authors.lastname: Yonemochi
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan. Electronic address: kiyohiko.sugano@phar.toho-u.ac.jp.
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Sugano
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan.
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Tarada
mesh_terms: D001462:Barbital / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003620:Dantrolene / Q000737:chemistry; D009853:Omeprazole / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D055672:Static Electricity
chemical_list: D002264:Carboxylic Acids; D012492:Salts; D001462:Barbital; D003620:Dantrolene; D009853:Omeprazole
keywords: Active pharmaceutical ingredient; Sodium salt; Standard carrier beads; Triboelectrification; Weak acid; Zero-charge margin