title: BDNF levels in adipose tissue and hypothalamus were reduced in mice with MSG-induced obesity.
abstract: OBJECTIVE
  To observe the expression of brain-derived neurotrophic factor (BDNF) in hypothalamic and adipose tissue in mice with monosodium glutamate (MSG)-induced obesity.
  
  
  METHODS
  The effects of hypothalamic lesions, specifically arcuate nucleus (ARC) lesions, induced by MSG injection were studied in male ICR mice at the neonatal stage. The following parameters were compared: body weight, body length, Lee's index, food intake, body temperature, fat weight, and levels of total cholesterol (CHOL), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and blood glucose (GLU). The BDNF expression levels in hypothalamic and adipose tissue were measured using western blotting. Results Compared with the control group, the model group body had significantly higher weight, Lee's index, food intake, fat weight, CHOL, TG, LDL, HDL, and GLU levels. BDNF expression levels in hypothalamic and adipose tissue were markedly down-regulated in the model group.
  
  
  CONCLUSIONS
  BDNF may be closely associated with MSG-induced hypothalamic obesity.
authors.forename: Yong Jun
authors.initials: YJ
authors.lastname: Jin
authors.forename: Peng Juan
authors.initials: PJ
authors.lastname: Cao
authors.forename: Wei Hua
authors.initials: WH
authors.lastname: Bian
authors.forename: Ming E
authors.initials: ME
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
authors.forename: Ling Yun
authors.initials: LY
authors.lastname: Zhang
authors.forename: Mei Zi
authors.initials: MZ
authors.lastname: Yang
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D015536:Down-Regulation; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009765:Obesity / Q000139:chemically induced / Q000503:physiopathology*; D009929:Organ Size; D012970:Sodium Glutamate; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D012970:Sodium Glutamate
keywords: Brain-derived neurotrophic factor (BDNF); Hypothalamic obesity; Monosodium glutamate (MSG); mouse model.