title: Strategically Modified Rhodamine-Quinoline Conjugate as a CHEF-Assisted FRET Probe for Au(3+): DFT and Living Cell Imaging Studies.
abstract: A systematic journey from O-donor through S-donor to N-donor chelator led to the development of a highly selective Au(3+) chemosensor that operates via a CHEF-induced FRET mechanism. This sensing protocol avoids unwanted possible side reactions observed in alkyne-based gold sensors. DFT studies strongly support the experimental facts. The probe RT-2 detects Au(3+) in the presence of the masking agent KI to minimize Hg(2+) interference; however, RQ-2 selectively detects Au(3+) without any interference and shows reversibility in the sensing in the presence of tetrabutylammonium cyanide. The probe efficiently images Au(3+) in living HeLa cells under a fluorescence microscope.
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, West Bengal, India.
authors.forename: Susanta
authors.initials: S
authors.lastname: Adhikari
authors.affiliation: Department of Chemistry, The University of Burdwan , Burdwan 713104, West Bengal, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Mandal
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, West Bengal, India.
authors.forename: Avijit
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Centre for Advanced Materials, Indian Association for the Cultivation of Scienc e, Kolkata 700032, West Bengal, India.
authors.forename: Pradip
authors.initials: P
authors.lastname: Das
authors.affiliation: Department of Chemistry, The University of Burdwan , Burdwan 713104, West Bengal, India.
authors.forename: Debasis
authors.initials: D
authors.lastname: Das
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D022781:Hepatocytes; D006801:Humans; D015394:Molecular Structure; D011789:Quantum Theory; D011804:Quinolines / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D011804:Quinolines; D012235:Rhodamines; D006046:Gold; C037219:quinoline