title: Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization.
abstract: Various racial and geographic differences have been observed in studies questioning the role of Epstein-Barr virus (EBV) infection in the etiology of T- and NK-cell lymphomas. The aim of this study was to evaluate the relationship of EBV with nodal or extranodal (skin excluded) T- and NK-cell lymphoma subtypes encountered in our geographic area. Sixty-two cases of peripheral T-cell lymphoma were included in the study. EBV-encoded early RNA (EBER) was detected by in situ hybridization. The distributions of T- and NK-cell lymphoma subtypes were as follows: 32 peripheral T-cell lymphomas, unspecified (PTCL, NOS), 13 anaplastic large-cell lymphomas (ALCL), 8 angioimmunoblastic T-cell lymphomas (AITCL), 4 extranodal NK/T-cell lymphomas, nasal type (NKTCL), 3 enteropathy-type T-cell lymphomas (ETTCL), 1 hepatosplenic T-cell lymphoma (HSTCL), and 1 subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Using a cut-off value of >25% of EBER-positive neoplastic lymphoid cells, EBV was positive in 22.6% of all cases. According to subtype, the neoplastic cells of 31.3% of PTCL, NOS and 100% of extranodal NKTCL, nasal type were EBER positive, whereas some cases of ALCL, AITCL, and ETTCL presented EBER-positive non‑neoplastic cells, and all cells of HSTCL and SPTCL were EBV negative. Extranodal NKTCL, nasal type, presented the strongest association with EBV, followed by PTCL, NOS.
authors.affiliation: Serap Karaarslan, Sifa University Faculty of Medicine, Department of Pathology, Sanayi Caddesi No:7, Bornova, Izmir 35100 Turkye, tel. +90 (232) 343 44 45, fax +90 (232) 343 56 56, e-mail: serapkaraarslan@gmail.com.
authors.forename: Serap
authors.initials: S
authors.lastname: Karaarslan
authors.forename: Mine
authors.initials: M
authors.lastname: Hekimgil
authors.forename: Saliha
authors.initials: S
authors.lastname: Soydan
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Ertan
authors.forename: Başak
authors.initials: B
authors.lastname: Doğanavşargil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000502:physiology; D006801:Humans; D017403:In Situ Hybridization; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology*; D054391:Lymphoma, Extranodal NK-T-Cell / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D016411:Lymphoma, T-Cell, Peripheral / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology; D017735:Virus Latency; D055815:Young Adult
chemical_list: D012367:RNA, Viral