title: IL-23, rather than IL-17, is crucial for the development of ovalbumin-induced allergic rhinitis.
abstract: Interleukin-23 (IL-23) and IL-17 are involved in the pathogenesis of allergic rhinitis (AR). However, the roles of IL-23 and IL-17 in ovalbumin (OVA)-induced AR remain unclear. Therefore in this study we aim to investigate the precise roles of IL-23 and IL-17 in a mouse model of OVA-induced AR. We found that during OVA-induced AR, eosinophil and goblet cells in the nose were significantly decreased in IL-23-deficient, but not in IL-17-deficient mice. However, there was no difference in the serum IgE and IgG1 levels between IL-23-deficient or IL-17-deficient and wild-type mice. Moreover, IL-4 levels in lymph node cell culture supernatants were significantly decreased in IL-23-deficient, but not IL-17-deficient, compared with wild-type mice. Furthermore, OVA-induced AR developed similarly in wild-type mice transferred with either IL-23-deficient BM cells or wild-type BM cells. These findings suggest that IL-23, but not IL-17 is crucial for the development of OVA-induced AR, and IL-23 neutralization may be a potential approach for treatment of OVA-induced AR in humans.
authors.affiliation: Qingdao Municiple Hospital, No. 5 Donghai Middle Road, Shinan District, Qingdao 266000, China. Electronic address: okhanqing@163.com.
authors.forename: Chaobin
authors.initials: C
authors.lastname: Guo
authors.affiliation: The Third People's Hospital of Qingdao, No. 29 Yongping Road, Licang District, Qingdao 66041, China.
authors.forename: Guie
authors.initials: G
authors.lastname: Chen
authors.affiliation: The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao 266003, China.
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Ge
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D004195:Disease Models, Animal; D004802:Eosinophilia / Q000378:metabolism / Q000473:pathology; D005260:Female; D020397:Goblet Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D020381:Interleukin-17 / Q000378:metabolism*; D053759:Interleukin-23 / Q000378:metabolism*; D015847:Interleukin-4 / Q000096:biosynthesis; D007962:Leukocytes / Q000378:metabolism / Q000473:pathology; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000276:immunology*; D065631:Rhinitis, Allergic / Q000139:chemically induced* / Q000276:immunology* / Q000473:pathology; D013234:Stem Cells / Q000166:cytology; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology; D015854:Up-Regulation
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D015847:Interleukin-4; D010047:Ovalbumin
keywords: Allergic rhinitis; Eosinophil; IL-17; IL-23