title: Secondary Solid Malignancies After High-Grade Glioma Treatment in Pediatric Patients.
abstract: Due to the poor survival in high-grade glioma (HGG), secondary solid malignancies (SSM) following pediatric HGG are scarce. The authors present the experience from the HIT-HGG database in Germany, Austria, and Switzerland. Five out of 1228 pediatric HGG patients developed a SSM following a latency of 29-122 months from primary HGG diagnosis. In 4 patients, the SSM may be attributed to previous radiotherapy or a tumor predisposition syndrome, reflected by a markedly increased cumulative incidence rate of SSM in patients with tumor predisposition. Survival was devastating, since none of the patients survived beyond 18 months from SSM diagnosis.
authors.affiliation: a Department of Pediatric and Adolescent Medicine, University Medical Center Mannheim, Medical Faculty Mannheim , Heidelberg University , Mannheim, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Karremann
authors.affiliation: b Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health , University Medical Center Göttingen , Göttingen, Germany.
authors.forename: Marion
authors.initials: M
authors.lastname: Hoffmann
authors.affiliation: c Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine , Medical University Graz , Graz, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Benesch
authors.affiliation: d Institute of Biostatistics and Clinical Research , University of Münster , Münster, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Kwiecien
authors.affiliation: b Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health , University Medical Center Göttingen , Göttingen, Germany.
authors.forename: André O
authors.initials: AO
authors.lastname: von Bueren
authors.affiliation: b Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health , University Medical Center Göttingen , Göttingen, Germany.
authors.forename: Christof M
authors.initials: CM
authors.lastname: Kramm
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D005910:Glioma / Q000401:mortality / Q000628:therapy; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016609:Neoplasms, Second Primary / Q000401:mortality / Q000628:therapy; D015996:Survival Rate
keywords: children; glioblastoma; high-grade glioma; secondary solid malignancies