title: Acetazolamide for electrical status epilepticus in slow-wave sleep.
abstract: Electrical status epilepticus in slow-wave sleep (ESES) is characterized by nearly continuous spike-wave discharges during non-rapid eye movement (REM) sleep. ESES is present in Landau-Kleffner syndrome (LKS) and continuous spike and wave in slow-wave sleep (CSWS). Sulthiame has demonstrated reduction in spike-wave index (SWI) in ESES, but is not available in the United States. Acetazolamide (AZM) is readily available and has similar pharmacologic properties. Our aims were to assess the effect of AZM on SWI and clinical response in children with LKS and CSWS. Children with LKS or CSWS treated with AZM at our institution were identified retrospectively. Pre- and posttherapy electroencephalography (EEG) studies were evaluated for SWI. Parental and teacher report of clinical improvement was recorded. Six children met criteria for inclusion. Three children (50%) demonstrated complete resolution or SWI <5% after AZM. All children had improvement in clinical seizures and subjective improvement in communication skills and school performance. Five of six children had subjective improvement in hyperactivity and attention. AZM is a potentially effective therapy for children with LKS and CSWS. This study lends to the knowledge of potential therapies that can be used for these disorders, which can be challenging for families and providers.
authors.affiliation: Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Fine
authors.affiliation: Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Elaine C
authors.initials: EC
authors.lastname: Wirrell
authors.affiliation: Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Lily C
authors.initials: LC
authors.lastname: Wong-Kisiel
authors.affiliation: Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Nickels
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D012189:Retrospective Studies; D012894:Sleep Stages / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000086:Acetazolamide
keywords: Acetazolamide; Continuous spike and wave in slow-wave sleep; Electrical status epilepticus in slow-wave sleep; Landau-Kleffner syndrome; Spike-wave index