title: Liposome-like nanocapsules of dual drug-tailed betaine for cancer therapy.
abstract: A novel dual drug-tailed betaine conjugate amphiphile has been firstly synthesized in which the polar headgroup is derived from glycine betaine and the hydrophobic tails are chlorambucil molecules. The newly prepared conjugate undergoes self-assembly to form stable liposome-like nanocapsules as an effective carrier with high drug loading capacity. The nanocapsules showed higher cytotoxic effects to cancer cell lines than those of free chlorambucil in vitro, and inhibited tumor growth effectively in vivo. This strategy that utilizes new dual drug-tailed betaine conjugate amphiphile to construct a self-assembled nanoparticle drug delivery system may have great potential in cancer chemotherapy.
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, PR China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Fang
authors.affiliation: Institute of Food and Nutraceutical Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Yuge
authors.initials: Y
authors.lastname: Niu
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, PR China.
authors.forename: Yemin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, United States.
authors.forename: Liangli
authors.initials: L
authors.lastname: Yu
authors.affiliation: National Center for Protein Science, Shanghai 201203, PR China.
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, PR China. Electronic address: lixs@seu.edu.cn.
authors.forename: Xinsong
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001622:Betaine / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D002699:Chlorambucil / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004355:Drug Stability; D005260:Female; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D008081:Liposomes; D061986:MCF-7 Cells; D051379:Mice; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008081:Liposomes; D053769:Nanocapsules; D002699:Chlorambucil; D001622:Betaine
keywords: Antitumor activity; Chlorambucil; Dual drug-tailed betaine; Liposome-like nanocapsules; Self-assembly