title: Administration of romosozumab improves vertebral trabecular and cortical bone as assessed with quantitative computed tomography and finite element analysis.
abstract: Romosozumab inhibits sclerostin, thereby increasing bone formation and decreasing bone resorption. This dual effect of romosozumab leads to rapid and substantial increases in areal bone mineral density (aBMD) as measured by dual-energy X-ray absorptiometry (DXA). In a phase 1b, randomized, double-blind, placebo-controlled study, romosozumab or placebo was administered to 32 women and 16 men with low aBMD for 3 months, with a further 3-month follow-up: women received six doses of 1 or 2mg/kg every 2 weeks (Q2W) or three doses of 2 or 3mg/kg every 4 weeks (Q4W); men received 1mg/kg Q2W or 3mg/kg Q4W. Quantitative computed tomography (QCT) scans at lumbar (L1-2) vertebrae and high-resolution QCT (HR-QCT) scans at thoracic vertebra (T12) were analyzed in a subset of subjects at baseline, month 3, and month 6. The QCT subset included 24 romosozumab and 9 placebo subjects and the HR-QCT subset included 11 romosozumab and 3 placebo subjects. The analyses pooled the romosozumab doses. Linear finite element modeling of bone stiffness was performed. Compared with placebo, the romosozumab group showed improvements at month 3 for trabecular BMD by QCT and HR-QCT, HR-QCT trabecular bone volume fraction (BV/TV) and separation, density-weighted cortical thickness, and QCT stiffness (all p<0.05). At month 6, improvements from baseline were observed in QCT trabecular BMD and stiffness, and in HR-QCT BMD, trabecular BV/TV and separation, density-weighted cortical thickness, and stiffness in the romosozumab group (all p<0.05 compared with placebo). The mean (SE) increase in HR-QCT stiffness with romosozumab from baseline was 26.9% ± 6.8% and 35.0% ±6.8% at months 3 and 6, respectively; subjects administered placebo had changes of -2.7% ± 13.4% and -6.4% ± 13.4%, respectively. In conclusion, romosozumab administered for 3 months resulted in rapid and large improvements in trabecular and cortical bone mass and structure as well as whole bone stiffness, which continued 3 months after the last romosozumab dose.
authors.affiliation: Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany; GSI, Darmstadt, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Graeff
authors.affiliation: Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
authors.forename: Graeme M
authors.initials: GM
authors.lastname: Campbell
authors.affiliation: Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
authors.forename: Jaime
authors.initials: J
authors.lastname: Peña
authors.affiliation: Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany; Institut und Poliklinik für Diagnostische Radiologie, Uniklinik Köln, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Borggrefe
authors.affiliation: Amgen Inc., Thousand Oaks, CA, USA.
authors.forename: Desmond
authors.initials: D
authors.lastname: Padhi
authors.affiliation: Amgen Inc., Thousand Oaks, CA, USA.
authors.forename: Allegra
authors.initials: A
authors.lastname: Kaufman
authors.affiliation: Amgen Inc., Thousand Oaks, CA, USA.
authors.forename: Sung
authors.initials: S
authors.lastname: Chang
authors.affiliation: Amgen Inc., Thousand Oaks, CA, USA.
authors.forename: Cesar
authors.initials: C
authors.lastname: Libanati
authors.affiliation: Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Electronic address: glueer@rad.uni-kiel.de.
authors.forename: Claus-Christian
authors.initials: CC
authors.lastname: Glüer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000627:therapeutic use; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D008159:Lumbar Vertebrae / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy*; D017698:Postmenopause; D013904:Thoracic Vertebrae / Q000187:drug effects; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D050071:Bone Density Conservation Agents; C557282:romosozumab
keywords: Bone mineral density; Bone quantitative computed tomography; Romosozumab; Sclerostin