title: One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes.
abstract: A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor-acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, USA. mrubin@ku.edu.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Maslivetc
authors.forename: Marina
authors.initials: M
authors.lastname: Rubina
authors.forename: Michael
authors.initials: M
authors.lastname: Rubin
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D005680:gamma-Aminobutyric Acid / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D003521:Cyclopropanes; D005680:gamma-Aminobutyric Acid; C021985:cyclopropene