title: Microwave-assisted fabrication of strontium doped apatite coating on Ti6Al4V.
abstract: Strontium has been shown to be a beneficial dopant to calcium phosphates when incorporated at nontoxic level. In the present work we studied the possibility of solution derived doping strontium into calcium phosphate coatings on titanium alloy Ti6Al4V based implants by a recently reported microwave-assisted method. By using this method strontium doped calcium phosphate nuclei were deposited to pretreated titanium alloy surface dot by dot to compose a crack-free coating layer. The presence of strontium in solution led to reduced roughness of the coating and finer nucleus size formed. In vitro study found that proliferation and differentiation of osteoblast cells seeded on the coating were influenced by strontium content in coatings, showing an increasing followed by a decreasing behavior with increasing substitution of calcium by strontium. It is suggested that this new microwave-assisted strontium doped calcium phosphate coatings may have great potential in implant modification.
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China. Electronic address: huanzhou@cczu.edu.cn.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China; School of Materials Science and Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.
authors.forename: Shiqin
authors.initials: S
authors.lastname: Kong
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China. Electronic address: dlh@cczu.edu.cn.
authors.forename: Linhong
authors.initials: L
authors.lastname: Deng
mesh_terms: D000497:Alloys / Q000737:chemistry; D000818:Animals; D001031:Apatites / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D051379:Mice; D008872:Microwaves; D010006:Osteoblasts / Q000187:drug effects; D019736:Prostheses and Implants; D013324:Strontium / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D001031:Apatites; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C031462:titanium alloy (TiAl6V4); C020243:calcium phosphate; D014025:Titanium; D013324:Strontium
keywords: Calcium phosphate; Coating; Microwave; Strontium