title: miRNA-15a/16: as tumor suppressors and more.
abstract: Since their first discovery in chronic lymphocytic leukemia, miR-15a and miR-16 have been reported to act as tumor suppressors or potential oncomiRs in different types of cancer. This review summarizes the history, biological properties and the important functions of these two miRNAs in cancer. It also introduces their roles as regulators of immune responses and angiogenesis, endogenous controls as well as potential targets and hallmarks of cancer.
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Enyu
authors.initials: E
authors.lastname: Huang
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, People's Republic of China.|Biotherapy Research Center, Fudan University, Shanghai 200032, People's Republic of China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Chu
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D056747:Immunomodulation / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000235:genetics
chemical_list: C505361:MIRN15 microRNA, human; C505362:MIRN16 microRNA, human; D035683:MicroRNAs
keywords: angiogenesis; cancer hallmarks; cancer therapy; immune regulator; miRNA