title: The COL5A1 genotype is associated with range of motion.
abstract: OBJECTIVE
  The aim of our study was to investigate the association between COL5A1 genotype and Range of Motion as measured by the passive straight leg raise (SLR) and whole body join laxity (WBJL) in Asian population.
  
  
  METHODS
  One hundred and seventy seven participants including Korean and Japanese college students (male = 109, female = 68) participated in the study. Each subject performed the passive straight leg raise and whole body join laxity test. Genotyping for the COL5A1 (rs 12722) polymorphism was performed using the TaqMan approach. The COL5A1 genotype exhibited a Hardy-Weinberg equilibrium distribution in our population.
  
  
  RESULTS
  The physical parameters including height, weight, and BMI were higher in < 90° group than > 90° group. The SLR exhibited significant difference among the COL5A1 group. However, the WBJL did not differ significantly among the COL5A1 genotype, but significant difference was seen in CC genotype when compared to CT (2.99 ± 1.72) or TT (2.70 ± 1.52) genotype.
  
  
  CONCLUSIONS
  We concluded that COL5A1 gene polymorphism is associated with increased SLR ROM in Asian population.
authors.affiliation: College of Sport Science, Dong-A University, Busan, Republic of Korea.
authors.forename: Seung-Taek
authors.initials: ST
authors.lastname: Lim
authors.affiliation: Department of Physical Education, Dongduk Women's University, Seoul, Republic of Korea.
authors.forename: Chang-Sun
authors.initials: CS
authors.lastname: Kim
authors.affiliation: College of Sport Science, Dong-A University, Busan, Republic of Korea.
authors.forename: Woo-Nam
authors.initials: WN
authors.lastname: Kim
authors.affiliation: Korea Institute of Sports Science (KISS), Seoul, Republic of Korea.
authors.forename: Seok-Ki
authors.initials: SK
authors.lastname: Min
keywords: COL5A1; ROM; SLR; flexibility; genotype