title: Reconstruction using massive allografts after resection of extremity osteosarcomas the study design: A retrospective cohort study.
abstract: OBJECTIVE
  Allografts have been shown useful in the reconstruction of bone defects after tumor resection. This study aimed to investigate the feasibility of using massive allografts to reconstruct bone defects after resection of extremity osteosarcomas.
  
  
  METHODS
  The clinical data of 15 patients treated with massive allograft reconstruction after resection of extremity osteosarcomas from January 2005 to January 2008 were retrospectively reviewed. Neoadjuvant and postoperative chemotherapy was used in all patients. The postoperative functions of the salvaged limbs were evaluated using the scoring system proposed by the Musculoskeletal Tumor Society (MSTS).
  
  
  RESULTS
  All patients were followed up for a mean of 61 months (range, 14-99 months). No nonunion occurred during follow-up. The mean time to union was 9 months (range, 3-21 months). No immune rejection, allograft infection, allograft fracture, and limb length disparity occurred. However, 2 patients had broken implants. The mean MSTS score at the last follow-up was 26 points. Four patients died and 2 patients had tumor recurrence. The 5-year disease free survival rate was 73.3%.
  
  
  CONCLUSIONS
  Massive allograft reconstruction is safe and effective for bone defects caused by resection of extremity osteosarcomas.
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China. Electronic address: Yanwang16@yeah.net.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Bi
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Jia
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Xiaoque
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Mei
authors.affiliation: Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D064591:Allografts; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation; D002648:Child; D015331:Cohort Studies; D018572:Disease-Free Survival; D005121:Extremities / Q000601:surgery*; D005260:Female; D005269:Femur / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D023821:Limb Salvage; D008297:Male; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D013977:Tibia / Q000601:surgery; D055815:Young Adult
keywords: Allograft; Bone defect; Chemotherapy; Extremity; Limb salvage; Osteosarcoma