title: Dental extraction in patients receiving dual antiplatelet therapy.
abstract: BACKGROUND
  Dual antiplatelet therapy consists of administering antiplatelet (antiaggregant) drugs (clopidogrel and aspirin) to prevent thrombotic processes, as a preventative measure in patients with acute coronary disease, or in patients subjected to percutaneous coronary intervention.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the efficacy of a protocol for performing dental extraction in patients receiving dual antiplatelet therapy.
  
  
  METHODS
  Thirty-two patients undergoing dental extractions were included in the study. The variables evaluated were: collagen-epinephrine fraction, collagen- adenosine diphosphate fraction, surgical surface, post-surgical measures, and adverse effects. Alveolar sutures and gauzes impregnated with an antifibrinolytic agent (tranexamic acid), which the patient pressed in place for 30 minutes, were applied to all patients as post-surgical measures. Descriptive statistics were calculated and analyzed with Student's t-test to compare pairs of quantitative variables; simple regression analysis was performed using Pearson's correlation coefficient. Statistical significance was set at p<0.05.
  
  
  RESULTS
  Collagen/epinephrine fraction was 264.53±55.624 seconds with a range of 135 to 300 seconds, and collagen/ADP fraction was 119.41±44.216 seconds, both values being higher than normal. As a result of the post-surgical measures taken, no patients presented post-operative bleeding, hematoma or infection.
  
  
  CONCLUSIONS
  Dental extraction was safe for patients receiving dual anti-platelet therapy when using sutures and gauze impregnated with tranexamic acid, which the patient pressed in place for 30 minutes.
authors.affiliation: Department of Special Care in Dentistry, Master of Periodontology and Implant Dentistry, and Pharmacological Research in Dentistry, Faculty of Dentistry, University of Granada, Colegio Máximo s/n, E18071 Granada, Spain, ggomez@ugr.es.
authors.forename: Paulino
authors.initials: P
authors.lastname: Sánchez-Palomino
authors.forename: Paulino
authors.initials: P
authors.lastname: Sánchez-Cobo
authors.forename: Alberto
authors.initials: A
authors.lastname: Rodriguez-Archilla
authors.forename: Maximino
authors.initials: M
authors.lastname: González-Jaranay
authors.forename: Gerardo
authors.initials: G
authors.lastname: Moreu
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Calvo-Guirado
authors.forename: Miguel
authors.initials: M
authors.lastname: Peñarrocha-Diago
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gómez-Moreno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care / Q000379:methods*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D014081:Tooth Extraction
chemical_list: D010975:Platelet Aggregation Inhibitors