title: Three new HLA-C alleles (HLA-C*14:02:13, HLA-C*15:72 and HLA-C*15:74) in Saudi bone marrow donors.
abstract: Three new HLA-C alleles were identified by sequence-based typing method (SBT) in donors for the Saudi Bone Marrow Donor Registry (SBMDR). HLA-C*14:02:13 differs from HLA-C*14:02:01 by a silent G to A substitution at nucleotide position 400 in exon 2, where lysine at position 66 remains unchanged. HLA-C*15:72 differs from HLA-C*15:22 by a nonsynonymous C to A substitution at nucleotide position 796 in exon 3, resulting in an amino acid change from phenylalanine to leucine at position 116. HLA-C*15:74 differs from HLA-C*15:08 by a nonsynonymous C to T substitution at nucleotide position 914 in exon 3, resulting in an amino acid change from arginine to tryptophan at position 156.
authors.affiliation: Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: H A
authors.initials: HA
authors.lastname: Fakhoury
authors.affiliation: King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: D
authors.initials: D
authors.lastname: Jawdat
authors.affiliation: King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: A S
authors.initials: AS
authors.lastname: Alaskar
authors.affiliation: King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: Al Jumah
authors.affiliation: Histogenetics, Ossining, NY, USA.
authors.forename: N
authors.initials: N
authors.lastname: Cereb
authors.affiliation: Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi Arabia.|Saudi Stem Cell Donor Registry, King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: A H
authors.initials: AH
authors.lastname: Hajeer
mesh_terms: D000483:Alleles; D001483:Base Sequence; D001853:Bone Marrow / Q000378:metabolism*; D015236:HLA-C Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D014019:Tissue Donors
chemical_list: D015236:HLA-C Antigens