title: Matrix metalloproteinase 9 expression and survival of patients with osteosarcoma: a meta-analysis.
abstract: Several studies have evaluated the effect of matrix metalloproteinase-9 (MMP-9) expression on the overall survival of patients with osteosarcoma, but the results remain conflicting. To examine the prognostic significance of MMP-9 expression in osteosarcoma risk, we conducted this meta-analysis to systematically review the published studies. We searched the commonly used electronic databases updated to September 2013 for relevant studies which evaluated the correction between MMP-9 expression and survival of patients with osteosarcoma. Overall, a total of eight studies including 437 cases were screened out. No significant heterogeneity was observed between studies. The MMP-9 was expressed in 73.9% (323/437) of cases, and the results showed that MMP-9 expression was associated with increased mortality rate of osteosarcoma during the follow-up (risk ratio = 2.79, 95% confidence interval, CI = 1.96-3.97, P < 0.00001). By ethnicity analysis, a significant correction was also found between MMP-9 expression and osteosarcoma risk among Asian and non-Asian population (P < 0.001), indicating that MMP-9 was an indicator of prognosis of osteosarcoma. In conclusion, this meta-analysis indicated that MMP-9 expression might be a biomarker of poor prognosis for patients with osteosarcoma. However, the prognostic value of MMP-9 on survival of osteosarcoma patients still needs further large-scale trials to be clarified.
authors.affiliation: Department of Orthopedic Surgery, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pharmacology, Medical College of Hebei University of Engineering, Handan, Hebei.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Orthopedic Surgery, People's Hospital of Yuxi City, Yuxi, Yunnan.
authors.forename: Z
authors.initials: Z
authors.lastname: Teng
authors.affiliation: Department of Orthopedic Surgery, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Orthopedic Surgery, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Orthopedic Surgery, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Orthopedic Surgery, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei.
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Orthopedic Surgery, General Hospital of Jizhong Energy Fengfeng Group, Handan, Hebei, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000201:enzymology / Q000401:mortality*; D002648:Child; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D016017:Odds Ratio; D012516:Osteosarcoma / Q000201:enzymology / Q000401:mortality*; D011379:Prognosis; D055815:Young Adult
chemical_list: D020780:Matrix Metalloproteinase 9
keywords: matrix metalloproteinase 9; meta-analysis; osteosarcoma