title: Efficacy of simple integrated group rehabilitation program for patients with knee osteoarthritis: Single-blind randomized controlled trial.
abstract: We investigated the role of an evidence-based integrated group rehabilitation program on the treatment of patients with knee osteoarthritis (KOA). This was a two-group, randomized controlled, 8 wk trial with 41 patients with moderate to very severe KOA. Patients were assigned to an intervention group (IG) or control group (CG). After both groups had received a self-management education program, IG participants underwent a rehabilitation program, including educational aspects about KOA followed by exercises. CG participants received only general health orientation about KOA during this period. The outcome measures were the Lequesne algofunctional index; 36-Item Short Form Health Survey (SF-36); and chair-stand, sit-and-reach, timed up-and-go, and 6-minute walk tests. Analysis of covariance revealed significant postintervention improvements of IG participants compared with CG participants (p < 0.05) on Lequesne total score and pain and function subdomains; SF-36 physical function, role physical, bodily pain, general health, vitality, and role emotional subdomains; and performance assessed by chair-stand, timed up-and-go, and 6-minute walk tests. Focusing on the primary outcome (Lequesne total score), the mean +/- standard deviation after 8 wk was 5.50 +/- 2.98 for the IG and 7.87 +/- 3.48 for the CG (p = 0.009). The corresponding effect size (partial eta squared with 90% confidence interval) was 0.23 (0.04-0.42), indicating a large effect. The presented rehabilitation program reduced pain and improved quality of life and function in patients with KOA.
  
  
  BACKGROUND
  ClinicalTrials.gov; Progressive Collective-exercise Program on the Knee Osteoarthritis; NCT01850862; https://clinicaltrials.gov/ct2/show/NCT01850862?term=NCT01850862&rank=1.
authors.affiliation: Department of Morphology, Biosciences Center, and.
authors.forename: Flávio S
authors.initials: FS
authors.lastname: da Silva
authors.forename: Flávio E S
authors.initials: FE
authors.lastname: de Melo
authors.forename: Marcelo M G
authors.initials: MM
authors.lastname: do Amaral
authors.forename: Vinícius V A
authors.initials: VV
authors.lastname: Caldas
authors.forename: Íria Lúcia D
authors.initials: ÍL
authors.lastname: Pinheiro
authors.forename: Bento J
authors.initials: BJ
authors.lastname: Abreu
authors.forename: Wouber H
authors.initials: WH
authors.lastname: Vieira
mesh_terms: D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology / Q000534:rehabilitation*; D011788:Quality of Life; D012189:Retrospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome
keywords: Lequesne; exercise therapy; group; knee; osteoarthritis; physical activity; randomized controlled trial; rehabilitation; self-management; stretching