title: Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction.
abstract: Advancing age is a major risk factor for the development of cardiovascular diseases. The aetiology of several cardiovascular disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q10 (CoQ10) acts as both an antioxidant and as an electron acceptor at the level of the mitochondria. Furthermore, in cardiac patients, plasma CoQ10 has been found to be an independent predictor of mortality. Based on the fundamental role of CoQ10 in mitochondrial bioenergetics and its well-acknowledged antioxidant properties, several clinical trials evaluating CoQ10 have been undertaken in cardiovascular disorders of ageing including chronic heart failure, hypertension, and endothelial dysfunction. CoQ10 as a therapy appears to be safe and well tolerated.
authors.affiliation: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China.
authors.forename: Yan-Kun
authors.initials: YK
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China.
authors.forename: Lin-Ping
authors.initials: LP
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Health Care, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Yao
authors.affiliation: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China.
authors.forename: Kun-Qi
authors.initials: KQ
authors.lastname: Yang
authors.affiliation: Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. Electronic address: gaolinggen@163.com.
authors.forename: Ling-Gen
authors.initials: LG
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China. Electronic address: zhouxianliang0326@hotmail.com.
authors.forename: Xian-Liang
authors.initials: XL
authors.lastname: Zhou
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D042783:Endothelial Cells / Q000187:drug effects* / Q000473:pathology*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; C024989:coenzyme Q10
keywords: Coenzyme Q10; Endothelial dysfunction; Heart failure; Hypertension