title: Nano-constructed Carriers Loaded With Antioxidant: Boon For Cardiovascular System.
abstract: In the last couple of decades antioxidant agents have entered the health market as an easy and attractive means of managing diseases. These agents are of enormous interest for an increasingly health-concerned society, and may be particularly relevant for prophylaxis of a number of diseases i.e. arthritis, cancer, metabolic and cardiovascular diseases, osteoporosis, cataracts, brain disorders, etc. Antioxidants are also favorable to vascular healthiness and symbolize useful compounds because they are able to diminish overall cardiovascular risk by acting analogous to first line therapy or as adjuvants in case of failure or in situations where first line therapy cannot be used. Furthermore, well-designed trials are indeed needed to improve the therapeutic efficacy and health benefits of antioxidants. Numerous in vivo proof-of-concepts studies are offered to underline the feasibility of nanostructure system in order to optimizing the delivery of cardiovascular drugs. The present review highlights the recent approaches for management of cardiovascular disease using different vesicular and particulate carriers, including liposomes, nanoparticles, and nanoemulsions, with a primary emphasis on those which are expected to enhance the antioxidants level.
authors.forename: Ashay
authors.initials: A
authors.lastname: Jain
authors.affiliation: Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201. prashantdops@gmail.com.
authors.forename: Prashant
authors.initials: P
authors.lastname: Kesharwani
authors.forename: Neeraj Kumar
authors.initials: NK
authors.lastname: Garg
authors.forename: Atul
authors.initials: A
authors.lastname: Jain
authors.forename: Pradip
authors.initials: P
authors.lastname: Nirbhavane
authors.forename: Nitin
authors.initials: N
authors.lastname: Dwivedi
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Banerjee
authors.forename: Arun K
authors.initials: AK
authors.lastname: Iyer
authors.forename: Mohd Cairul
authors.initials: MC
authors.lastname: Iqbal Mohd Amin
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D004337:Drug Carriers