title: Synthesis of the dendritic type β-cyclodextrin on primary face via click reaction applicable as drug nanocarrier.
abstract: The objective of this study was the syntheses of well-defined glycodendrimer with entrapment efficiency by click reactions, with β-cyclodextrins (β-CDs) moiety to keep the biocompatibility properties, besides especially increase their capacity to load numerous appropriate sized guests. The original dendrimer containing β-CD in both periphery and central was synthesized using click reaction. The entrapment property of the β-CD-dendrimer was studied by methotrexate (MTX) drug. The chemical structure of β-CD-dendrimer was characterized by (1)H NMR, (13)C NMR and FTIR and its inclusion complex structure were investigated by SEM, DLS, DSC and FTIR techniques. The cytotoxic effect of obtained compound and its inclusion complex with MTX was analyzed using MTT test. The MTT test exhibited that the synthesized compound was not cytotoxic to the cell line considered. The in vitro drug release study turned out that the obtained β-CD dendrimer could be a suitable controlled drug delivery system for cancer treatment.
authors.affiliation: Laboratory of Dendrimers and Nano-Biopolymers, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Toomari
authors.affiliation: Laboratory of Dendrimers and Nano-Biopolymers, Faculty of Chemistry, University of Tabriz, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science, Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Namazi
authors.affiliation: Laboratory of Dendrimers and Nano-Biopolymers, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
authors.forename: Entezami Ali
authors.initials: EA
authors.lastname: Akbar
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D057930:Click Chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D050091:Dendrimers; D047392:beta-Cyclodextrins; C031215:betadex; D008727:Methotrexate
keywords: Dendrimer; Inclusion complex; Methotrexate; Nanocarrier; β-Cyclodextrin