title: Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release.
abstract: The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China.
authors.forename: Mu-Ru
authors.initials: MR
authors.lastname: Xu
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Shi
authors.affiliation: School of Science, Engineering and Technology, Kydd Building, Abertay University, Dundee DD1 1HG, Scotland, UK.
authors.forename: David H
authors.initials: DH
authors.lastname: Bremner
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China.
authors.forename: Kan
authors.initials: K
authors.lastname: Sun
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China.
authors.forename: Hua-Li
authors.initials: HL
authors.lastname: Nie
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China; Key Laboratory of Science &Technology of Eco-Textile，Donghua University, Shanghai 201620, PR China. Electronic address: jquan@dhu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Quan
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China. Electronic address: lzhu@dhu.edu.cn.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Zhu
mesh_terms: D002209:Caprolactam / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D003373:Coumaric Acids / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005609:Free Radicals / Q000737:chemistry; D005690:Galactose / Q000737:chemistry; D005697:Galactosides / Q000737:chemistry* / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D037102:Lectins; D057139:Nanofibers / Q000737:chemistry* / Q000633:toxicity; D019887:Peanut Agglutinin / Q000737:chemistry; D058105:Polymerization; D011145:Polyvinyls / Q000737:chemistry* / Q000633:toxicity; D013696:Temperature
chemical_list: D003373:Coumaric Acids; D003692:Delayed-Action Preparations; D005609:Free Radicals; D005697:Galactosides; D037102:Lectins; D019887:Peanut Agglutinin; D011145:Polyvinyls; C000611227:poly(6-O-vinylnonanedioylgalactose-co-N-vinylcaprolactam); D002209:Caprolactam; C004999:ferulic acid; D005690:Galactose
keywords: Drug loaded nanofiber; Glycopolymer; Lectin binding; Sustained release; Thermoresponsive