title: A new flavan from the Drynaria bonii H. Christ rhizomes.
abstract: In Vietnam, the medicinal plant Drynaria bonii H. Christ is used for the treatment of osteoporosis, bone fractures, and stimulate the growth of hair, treat tinnitus (Ho 2002; Loi 2004). In this article, experiments were designed to investigate the proliferation activity of ethanol, n-hexane, chloroform, ethyl acetate and methanol extracts from D. bonii rhizomes on MG-63 human osteoblast-like cells. The results showed that methanol and hexane extracts had the ability to proliferate MG-63 cells at the concentration varying from 0.1 to 0.01 μg/mL. In particular, at the concentration of 0.01 μg/mL, hexane and methanol extracts illustrated the highest proliferation ratio with 9.31% and 6.16%, respectively. By column chromatography, a new compound named drynaether A (1) and five known compounds uracil (2), 4'-hydroxy-7-methoxyflavan (3), kaempferol (4), indole-3-carboxylic acid (5) and protocatechuic acid (6) were isolated and identified from the methanol extract.
authors.affiliation: a Tien Giang University , National Highway No. 1, Chau Thanh, Tien Giang , Vietnam.
authors.forename: Pham Thi Nhat
authors.initials: PT
authors.lastname: Trinh
authors.affiliation: b Institute of Chemical Technology, Vietnam Academy of Science and Technology , 01 Mac Dinh Chi, Dist. 1, Ho Chi Minh City , Vietnam.
authors.forename: Mai Dinh
authors.initials: MD
authors.lastname: Tri
authors.affiliation: b Institute of Chemical Technology, Vietnam Academy of Science and Technology , 01 Mac Dinh Chi, Dist. 1, Ho Chi Minh City , Vietnam.
authors.forename: Dang Chi
authors.initials: DC
authors.lastname: Hien
authors.affiliation: b Institute of Chemical Technology, Vietnam Academy of Science and Technology , 01 Mac Dinh Chi, Dist. 1, Ho Chi Minh City , Vietnam.
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: An
authors.affiliation: b Institute of Chemical Technology, Vietnam Academy of Science and Technology , 01 Mac Dinh Chi, Dist. 1, Ho Chi Minh City , Vietnam.
authors.forename: Phan Nhat
authors.initials: PN
authors.lastname: Minh
authors.affiliation: b Institute of Chemical Technology, Vietnam Academy of Science and Technology , 01 Mac Dinh Chi, Dist. 1, Ho Chi Minh City , Vietnam.
authors.forename: Pham Ngoc
authors.initials: PN
authors.lastname: An
authors.affiliation: b Institute of Chemical Technology, Vietnam Academy of Science and Technology , 01 Mac Dinh Chi, Dist. 1, Ho Chi Minh City , Vietnam.
authors.forename: Le Tien
authors.initials: le T
authors.lastname: Dung
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029621:Polypodiaceae / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D014744:Vietnam
chemical_list: C433580:4'-hydroxy-7-methoxyflavan; D005419:Flavonoids; D062385:Hydroxybenzoates; D007211:Indoles; D044949:Kaempferols; D010936:Plant Extracts; C000610647:drynaether A; C009091:protocatechuic acid; C012382:indole-3-carboxylic acid; C006552:kaempferol
keywords: Drynaria bonii; MG-63 cell; drynaether A