title: Antibiotic profiling of Clostridium difficile ribotype 176--A multidrug resistant relative to C. difficile ribotype 027.
abstract: Antibiotic profiling of twenty Czech Clostridium difficile PCR-ribotype 176 isolates revealed a high level of resistance to erythromycin, ciprofloxacin and moxifloxacin (n = 20) and to rifampicin (n = 13). Accumulation of resistance mechanisms to multiple antibiotics highlight that PCR-ribotype 176 belong to problematic epidemic strains.
authors.affiliation: Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Czech Republic; DNA laboratory, Department of Paediatric Neurology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Czech Republic. Electronic address: marcela.krutova@seznam.cz.
authors.forename: Marcela
authors.initials: M
authors.lastname: Krutova
authors.affiliation: Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Matejkova
authors.affiliation: Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Tkadlec
authors.affiliation: Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Czech Republic.
authors.forename: Otakar
authors.initials: O
authors.lastname: Nyc
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D016360:Clostridioides difficile / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D018153:Czech Republic; D024901:Drug Resistance, Multiple, Bacterial; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D021521:Ribotyping
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins
keywords: Clostridium difficile; Erythromycin; Moxifloxacin; PCR-ribotype 176; Resistance; Rifampicin; Thr82Ile