title: SOST polymorphisms and response to alendronate treatment in postmenopausal Chinese women with osteoporosis.
abstract: OBJECTIVE
  To investigate the association between SOST gene polymorphisms and response to alendronate treatment.
  
  
  METHODS
  639 Chinese postmenopausal women with osteoporosis or osteopenia received alendronate treatment. Polymorphisms of SOST were analyzed. Bone mineral density (BMD), serum ALP and β-CTX levels were measured. The correlation of SOST polymorphisms with changes of BMD and bone biomarkers after treatment was analyzed.
  
  
  RESULTS
  rs1234612 and rs851054 polymorphisms were correlated to baseline lumbar spine BMD (p < 0.05). After 12 months of treatment rs1234612 and rs865429 polymorphisms were correlated to BMD changes at the lumbar spine (p < 0.05) or femoral neck (p < 0.05), respectively.
  
  
  CONCLUSIONS
  The polymorphisms of SOST are genetic factors affecting bone health and response to alendronate in Chinese postmenopausal women.
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Pei-ran
authors.initials: PR
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Xu
authors.affiliation: Metabolic Bone Disease & Genetics Research Unit, Department of Osteoporosis & Bone Diseases, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Zhen-lin
authors.initials: ZL
authors.lastname: Zhang
authors.affiliation: Institute of Endocrinology & Metabolism, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
authors.forename: Er-yuan
authors.initials: EY
authors.lastname: Liao
authors.affiliation: Department of Endocrinology, Osteoporosis Education Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: De-cai
authors.initials: DC
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, Xijing Hospital, The Fourth Liberation Army University, Xi'an, Shaanxi, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Guangdong General Hospital, Guangzhou, Guangdong, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Ou
authors.initials: O
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Xia
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Xing
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D019386:Alendronate / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density / Q000187:drug effects / Q000235:genetics; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D019485:Bone Morphogenetic Proteins / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008159:Lumbar Vertebrae / Q000187:drug effects; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D017698:Postmenopause / Q000187:drug effects* / Q000235:genetics*; D011446:Prospective Studies
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D050071:Bone Density Conservation Agents; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C422903:SOST protein, human; D019386:Alendronate
keywords: SOST gene; osteoporosis; polymorphisms; response to alendronate