title: Lumbar spinal atypical teratoid rhabdoid tumor.
abstract: We describe a pediatric patient with an atypical teratoid rhabdoid tumor (AT/RT) exclusively of the lumbar spine, with a different presentation from the two previously reported pediatric lumbar AT/RT. AT/RT are rare pediatric tumors of the central nervous system, with a dismal prognosis. Although there is sufficient literature on brain AT/RT, spinal AT/RT continues to be a rare entity, with a lumbar location even less frequently reported. A 30-month-old African American boy with multiple comorbidities presented with the inability to ambulate, encopresis and urinary dribbling. The MRI showed an intradural extramedullary mass extending downwards from the L3-4 level. He underwent an L3-S2 laminoplasty. The surgically resected mass was marked by sheets of cells with large nuclei and prominent nucleoli. The tumor cells stained with antibodies to synaptophysin and CAM5.2, and showed no immunoreactivity to INI-1 antibody. He was diagnosed with a World Health Organization Grade IV AT/RT. There was no mutation detected in the SMARCB1 gene on a comprehensive analysis of his blood. The boy is currently being treated according to the Medical University of Vienna AT/RT protocol, with no evidence of tumor recurrence 8 months after surgery. To our knowledge, this is the only report of a lumbar AT/RT in an African American child.
authors.affiliation: Children's Department, Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Aditi
authors.initials: A
authors.lastname: Dhir
authors.affiliation: Children's Department, Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Tanya
authors.initials: T
authors.lastname: Tekautz
authors.affiliation: Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Violette
authors.initials: V
authors.lastname: Recinos
authors.affiliation: Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Murphy
authors.affiliation: Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
authors.affiliation: Department of Diagnostic Imaging, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Ruggieri
authors.affiliation: Children's Department, Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: wolffj@ccf.org.
authors.forename: Johannes
authors.initials: J
authors.lastname: Wolff
mesh_terms: D001741:Black or African American; D002675:Child, Preschool; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D018335:Rhabdoid Tumor / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000473:pathology*; D013724:Teratoma / Q000473:pathology*
keywords: Atypical teratoid rhabdoid tumor; Histopathology; Lumbar spinal tumor