title: Severe Quetiapine Withdrawal Syndrome with Nausea and Vomiting in a 65-year-old Patient with Psychotic Depression.
abstract: A 65-year old patient suffering from severe psychotic depression obtained quetiapine for roughly one year. Several attempts to discontinue quetiapine by tapering the dose provoked severe withdrawal symptoms with nausea and vomitus. Pretreatment with domperidone largely prevented withdrawal so that he finally could successfully discontinue quetiapine administration.
authors.forename: Horst J
authors.initials: HJ
authors.lastname: Koch
mesh_terms: D000341:Affective Disorders, Psychotic / Q000188:drug therapy*; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000494:pharmacology / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D031608:Area Postrema / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy*; D004294:Domperidone / Q000494:pharmacology / Q000627:therapeutic use*; D018492:Dopamine Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use; D008297:Male; D009325:Nausea / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D000069348:Quetiapine Fumarate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000209:etiology*; D000069470:Venlafaxine Hydrochloride / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000928:Antidepressive Agents; D000932:Antiemetics; D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D018020:Lithium Compounds; D017448:Receptors, Dopamine D2; D000069348:Quetiapine Fumarate; D004294:Domperidone; D000069470:Venlafaxine Hydrochloride