title: Sirtuin 1 and aging theory for chronic obstructive pulmonary disease.
abstract: Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. Recently it was suggested that Sirtuin 1 (SIRT1), an antiaging molecule involved in the response to oxidative stress and chronic inflammation, is implicated in both development and progression of COPD. The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. Recent evidence corroborating the statement of the "aging theory for COPD" was also discussed.
authors.affiliation: Department of Medicine and Surgery, University of Salerno, 84081 Baronissi, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Conti
authors.affiliation: Department of Medicine and Health Sciences, University of Molise, Via De Sanctis, 86100 Campobasso, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Corbi
authors.affiliation: Department of Medicine and Surgery, University of Salerno, 84081 Baronissi, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Manzo
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Campus Universitario "S. Venuta", Viale Europa-Località Germaneto, 88100 Catanzaro, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pelaia
authors.affiliation: Department of Medicine and Surgery, University of Salerno, 84081 Baronissi, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Filippelli
authors.affiliation: Department of Medicine and Surgery, University of Salerno, 84081 Baronissi, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Vatrella
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008954:Models, Biological; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000473:pathology*; D056564:Sirtuin 1 / Q000378:metabolism*
chemical_list: D056564:Sirtuin 1