title: Stereotactic Body Radiotherapy Results for Pulmonary Oligometastases: A Two-Institution Collaborative Investigation.
abstract: OBJECTIVE
  The current study investigated outcomes and prognostic factors of pulmonary oligometastases at two Institutions.
  
  
  METHODS
  SBRT (stereotactic body radiotherapy) as performed for pulmonary oligometastases from January 2004 to April 2014, and patients with a biologically effective dose (BED10) ≥ 75 Gy were registered in the study. Control of the primary tumor was not a criterion: we included both oligo-recurrence and sync-oligometastases.
  
  
  RESULTS
  A total of 34 patients were enrolled in the study. The median overall survival was 20 months (range=1-119 months) and the 2-year overall survival rate was 65.7% [95% confidence interval (CI)=48.3-83.1%]. The two-year local control rate was 79.1% (95% CI=62.4-95.8%). Stratified by oligo status, the 2-year overall survival rate of the oligo-recurrence group was 68.5% (95% CI=50.3-86.7%), while that of the group with sync-oligometastases was 50.0% (95% CI=1.0-99.0%). These rates were significantly different (p=0.037). No grade 5 early- or late-adverse events were recognized in the current study.
  
  
  CONCLUSIONS
  SBRT for pulmonary oligometastases achieved good results and there was no serious adverse event. The oligo-recurrence group, in particular, achieved fairly good results.
authors.affiliation: Department of Radiology, Toho University Omori Medical Center, Ota-ku, Tokyo, Japan Department of Radiation Oncology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan yniibe-toho@umin.org.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Niibe
authors.affiliation: Department of Radiology, the University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
authors.forename: Hideomi
authors.initials: H
authors.lastname: Yamashita
authors.affiliation: Department of Radiation Oncology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sekiguchi
authors.affiliation: Department of Radiology, the University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Takahashi
authors.affiliation: Department of Radiology, the University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
authors.forename: Kenshiro
authors.initials: K
authors.lastname: Shiraishi
authors.affiliation: Department of Radiology, the University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
authors.forename: Kae
authors.initials: K
authors.lastname: Okuma
authors.affiliation: Department of Radiology, the University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan Department of Radiation Oncology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan.
authors.forename: Atsuro
authors.initials: A
authors.lastname: Terahara
authors.affiliation: Department of Radiation Oncology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Kawamori
authors.affiliation: Department of Radiology, the University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D016634:Radiosurgery; D016019:Survival Analysis
keywords: Pulmonary oligometastases; SBRT; oligo-recurrence; sync-oligometastases