title: Evaluation of an automated spike-and-wave complex detection algorithm in the EEG from a rat model of absence epilepsy.
abstract: The aim of this prospective blinded study was to evaluate an automated algorithm for spike-and-wave discharge (SWD) detection applied to EEGs from genetic absence epilepsy rats from Strasbourg (GAERS). Five GAERS underwent four sessions of 20-min EEG recording. Each EEG was manually analyzed for SWDs longer than one second by two investigators and automatically using an algorithm developed in MATLAB®. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for the manual (reference) versus the automatic (test) methods. The results showed that the algorithm had specificity, sensitivity, PPV and NPV >94%, comparable to published methods that are based on analyzing EEG changes in the frequency domain. This provides a good alternative as a method designed to mimic human manual marking in the time domain.
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia. bauquier@unimelb.edu.au.
authors.forename: Sebastien H
authors.initials: SH
authors.lastname: Bauquier
authors.affiliation: Department of Electrical and Electronic Engineering, The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Lai
authors.affiliation: Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, VIC, Australia.|Faculty of Medicine, The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Jiang
authors.affiliation: Department of Neurology, Shenyang First People's Hospital, Shenyang, 110041, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sui
authors.affiliation: Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, VIC, Australia.|Faculty of Medicine, The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Cook
mesh_terms: D000465:Algorithms; D000818:Animals; D058256:Brain Waves; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods*; D004832:Epilepsy, Absence / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D011446:Prospective Studies; D051381:Rats; D055647:Rats, Transgenic; D012815:Signal Processing, Computer-Assisted
keywords: GAERS; epilepsy; seizure detection