title: Design of biomaterials for intracellular delivery of carbon monoxide.
abstract: Carbon monoxide (CO) is recognized as one of the most important gas signaling molecules involved in governing various therapeutic responses. Intracellular generation of CO is spatiotemporally controlled by catalytic reactions of heme oxygenases (HOs). Thus, the ability to control intracellular CO delivery with modulation of the CO-release rate in specific amounts and locations is expected to improve our fundamental understanding of the functions of CO and the development of clinical applications. For this purpose, CO-releasing molecules (CORMs) have been developed and investigated in vitro and in vivo. Most CORMs are based on transition metal carbonyl complexes. Recently, various biomaterials consisting of metal carbonyls with biomacromolecular scaffolds have been reported to improve the properties of bare metal carbonyls. In this mini-review, current progress in CO delivery, recent strategies for the development of CORMs, and future directions in this field are discussed.
authors.affiliation: Department of Chemistry, Roger Adams Laboratory, University of Illinois, 600 South Mathews, Urbana, Illinois 61801, USA.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inaba
authors.forename: Kenta
authors.initials: K
authors.lastname: Fujita
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ueno
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002248:Carbon Monoxide / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D006419:Heme Oxygenase (Decyclizing) / Q000737:chemistry* / Q000378:metabolism; D028561:Transition Elements / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D056831:Coordination Complexes; D028561:Transition Elements; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing)