title: Constructing heterostructure on highly roughened caterpillar-like gold nanotubes with cuprous oxide grains for ultrasensitive and stable nonenzymatic glucose sensor.
abstract: In this study, a metal-metal oxide heterostructure was designed and constructed by growing cuprous oxide (Cu2O) grains on highly surface roughened caterpillar-like Au nanotubes (CLGNs) for ultrasensitive, selective and stable nonenzymatic glucose biosensors. The Cu2O grains are tightly anchored to the surface of CLGNs by the spines, resulting in a large increase in the contact area between Cu2O grains and the CLGNs, which facilitates the electron transport between metal and metal oxide and improves the sensitivity and stability of the sensors. The electron transfer coefficient (α) and electron transfer rate constant (ks) for redox reaction of Cu2O-CLGNs/GCE are found to be 0.50114 and 3.24±0.1 s(-1), respectively. The biosensor shows a linear response to glucose over a concentration range of 0.1-5mM and a high sensitivity of 1215.7 µA mM(-1) cm(-2) with a detection limit of 1.83 μM. Furthermore, the Cu2O-CLGNs biosensor exhibited strong anti-interference capability against uric acid (UA), ascorbic acid (AA), potassium chloride (KCl) and sodium ascorbate (SA), as well as a high stability and repeatability. Our current research indicates that the Cu2O-CLGNs hybrid electrode is a promising choice for constructing nonenzyme based electrochemical biosensors.
authors.affiliation: MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China.
authors.forename: Anran
authors.initials: A
authors.lastname: Chen
authors.affiliation: MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ding
authors.affiliation: MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Academy of Xi'an Jiaotong University, 215000 Suzhou, People's Republic of China. Electronic address: zmyang@mail.xjtu.edu.cn.
authors.forename: Zhimao
authors.initials: Z
authors.lastname: Yang
authors.affiliation: MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Academy of Xi'an Jiaotong University, 215000 Suzhou, People's Republic of China. Electronic address: ysch1209@mail.xjtu.edu.cn.
authors.forename: Shengchun
authors.initials: S
authors.lastname: Yang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D003300:Copper / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D004566:Electrodes; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013499:Surface Properties
chemical_list: D006046:Gold; D003300:Copper; D005947:Glucose; C000520:cuprous oxide
keywords: Caterpillar-like Au nanotubes; Cu(2)O grains; Glucose biosensor; Heterostructure