title: Biomarkers in HCV Infection.
abstract: Liver-related biomarkers have been developed and validated mainly in patients with chronic hepatitis C for the prediction of liver fibrosis or cirrhosis, which is a final pathway of chronic liver injury. They are noninvasive, traceable, and easy-to-use. Biomarkers provide implications related to screening, diagnosis, treatment, and prognosis of chronic hepatitis. For the improvement of performance and coverage, biomarker panels, imaging biomarkers, and even genetic biomarkers have been developed. With the advancement of genomics and proteomics, earlier and more precise prediction is expected in the near future. In this review, multiple biomarker panels for the estimation of the degree of fibrosis in chronic hepatitis C, biomarkers for the screening and diagnosis of hepatitis C, biomarkers for the treatment of hepatitis C, biomarkers for the prediction of complications related to the chronic hepatitis C, and future perspectives will be summarized.
authors.affiliation: Department of Internal Medicine, Inje University College of Medicine, Busan, South Korea.
authors.forename: Seung Ha
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea.
authors.forename: Chang Seok
authors.initials: CS
authors.lastname: Bang
authors.affiliation: Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea. Electronic address: djkim@hallym.ac.kr.
authors.forename: Dong Joon
authors.initials: DJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D015415:Biomarkers; D023281:Genomics / Q000379:methods; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D011379:Prognosis
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers
keywords: Biomarkers; Hepatitis C; Hepatocellular carcinoma; Liver fibrosis; MicroRNAs