title: Bayley-III scales at 12 months of corrected age in preterm infants: Patterns of developmental performance and correlations to environmental and biological influences.
abstract: OBJECTIVE
  Premature infants are at high risk for neurodevelopmental impairment (NDI) even in the absence of known brain complications of prematurity. Evaluation of the effectiveness of therapeutic interventions in association to neurodevelopmental outcome is required to improve or prevent the neurodevelopmental consequences of prematurity. The Bayley-III is currently the most commonly applied measurement tool for assessing early development both in clinical practice and research settings.
  
  
  OBJECTIVE
  To evaluate the relationship between known risk factors and early performance on the Bayley Scales of Infant Development-Third Edition at 12 months adjusted age in premature infants.
  
  
  METHODS
  Prospective study in a cohort of premature infants with gestational age ≤32 weeks, who underwent comprehensive developmental assessment using the five domains of Bayley Scales, cognitive, language, motor, social emotional and adaptive behavior at 12 months corrected age. Developmental scores were evaluated in relation to environmental influences, therapeutic interventions or practices and complications of prematurity.
  
  
  RESULTS
  Composite and Subscale scores for the cognitive, language and motor scales were below the 50th percentile, with no significant differences among them. Scores for the social-emotional and adaptive behavior, which are derived from the parent-report questionnaires, were near the average and significantly higher than the scores derived by the examiners. Multiple regression analyses showed that blood transfusions, apart from severely abnormal head ultrasound, gender, being small for gestational age and duration of invasive mechanical ventilation and oxygen administration were consistently related to neurodevelopmental outcome.
  
  
  CONCLUSIONS
  Bayley-III assessments are important for getting early information about development following premature birth. Parents may overestimate children's performance. Neurodevelopmental outcome is related to several environmental, biological or medical conditions associated with prematurity. Adoption of therapeutic strategies targeting known neonatal risk factors could positively affect neurodevelopmental outcome.
authors.affiliation: Dept of Child Psychiatry, Ippokration General Hospital, Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Velikos
authors.affiliation: 1st Dept of Neonatology, Ippokration General Hospital, Aristotle University of Thessaloniki, Greece. Electronic address: soubasi@med.auth.gr.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Soubasi
authors.affiliation: Dept of Child Psychiatry, Ippokration General Hospital, Thessaloniki, Greece.
authors.forename: Irene
authors.initials: I
authors.lastname: Michalettou
authors.affiliation: 1st Dept of Neonatology, Ippokration General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: Kosmas
authors.initials: K
authors.lastname: Sarafidis
authors.affiliation: Lab of Biometry, University of Thessaly, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Nakas
authors.affiliation: Dept of Child Psychiatry, Ippokration General Hospital, Thessaloniki, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Papadopoulou
authors.affiliation: 1st Dept of Paediatrics, Ippokration General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Zafeiriou
authors.affiliation: 1st Dept of Neonatology, Ippokration General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Drossou
mesh_terms: D000223:Adaptation, Psychological; D001803:Blood Transfusion / Q000706:statistics & numerical data; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D002657:Child Development; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015331:Cohort Studies; D004453:Echoencephalography; D004777:Environment; D005260:Female; D006801:Humans; D007223:Infant; D062071:Infant, Extremely Premature; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D007804:Language Development; D007805:Language Development Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D009048:Motor Skills; D019957:Motor Skills Disorders / Q000175:diagnosis / Q000453:epidemiology*; D065886:Neurodevelopmental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D010102:Oxygen Inhalation Therapy / Q000706:statistics & numerical data; D011446:Prospective Studies; D012044:Regression Analysis; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012307:Risk Factors; D012737:Sex Factors; D012919:Social Behavior; D013997:Time Factors
keywords: Bayley-III; Development; Developmental assessment; Preterm infants; Transfusions