title: Comparison of 2 Dosages of Intraarticular Triamcinolone for the Treatment of Knee Arthritis: Results of a 12-week Randomized Controlled Clinical Trial.
abstract: OBJECTIVE
  To determine whether a double dose of intraarticular triamcinolone acetonide is more effective for knee arthritis than a 40-mg dose.
  
  
  METHODS
  In this 12-week randomized controlled clinical trial, 40 mg and 80 mg of intraarticular triamcinolone acetonide were compared in patients with knee arthritis. Evaluated variables included a Likert burden scale, visual analog scale pain scale, degree of arthritis activity, presence of swelling, and presence of functional limitation.
  
  
  RESULTS
  Ninety-seven patients were randomized. No significant differences were observed between the groups regarding any outcomes.
  
  
  CONCLUSIONS
  An 80-mg dose of triamcinolone acetonide had no additional benefit compared with 40 mg as treatment for knee arthritis.
  
  
  BACKGROUND
  Nederlands Trial Register; trial registration number: NTR2298.
authors.affiliation: From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente.
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: Popma
authors.affiliation: From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente. f.snel@zgt.nl.
authors.forename: Frank W
authors.initials: FW
authors.lastname: Snel
authors.affiliation: From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente.
authors.forename: Cees J
authors.initials: CJ
authors.lastname: Haagsma
authors.affiliation: From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente.
authors.forename: Petra
authors.initials: P
authors.lastname: Brummelhuis-Visser
authors.affiliation: From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente.
authors.forename: Hans G J
authors.initials: HG
authors.lastname: Oldenhof
authors.affiliation: From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente.
authors.forename: Job
authors.initials: J
authors.lastname: van der Palen
authors.affiliation: From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente.
authors.forename: Mart A F J
authors.initials: MA
authors.lastname: van de Laar
mesh_terms: D000328:Adult; D000368:Aged; D001168:Arthritis / Q000188:drug therapy* / Q000473:pathology*; D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy / Q000473:pathology; D010147:Pain Measurement; D011446:Prospective Studies; D016059:Range of Motion, Articular / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide
keywords: ARTHRITIS; DOSE-RESPONSE RELATIONSHIP; DRUG THERAPY; INJECTIONS; INTRAARTICULAR; TRIAMCINOLONE