title: Epstein-Barr virus DNA in colorectal carcinoma in Iranian patients.
abstract: Colorectal cancer is an often fatal cancer with a rapidly increasing incidence. Current mortality is estimated to be approximately 600,000 per year, and both environmental and genetic factors are involved in its etiology. Viral and bacterial factors have a proven role in the incidence of approximately 20% of cancers. In the present study, the Epstein-Barr virus (EBV) was detected in 50 colorectal adenocarcinomas, 12 colon adenomas, and 38 control tissue samples using polymerase chain reaction (PCR). Epstein-Barr virus DNA was identified in 19 of the adenocarcinoma tissues, 1 adenoma tissue and 24 control specimens. In total, 15.8% (3/18) of the colorectal samples in the well-differentiated grade, 79% (15/30) in the moderately differentiated, and 5.2% (1/2) in the poorly differentiated grade tested positive for viral infection. Epstein-Barr virus was more prevalent in the moderately differentiated grade. Statistical analysis did not suggest a significant association between EBV and the incidence of colorectal cancer. However, it appears that the virus stimulates progression of the malignancy.
authors.affiliation: Farzaneh Tafvizi, Department of Biology, Parand Branch, Islamic Azad University, 19987-45475 Tehran, Iran, tel. +98-912-5709532, e-mail: farzanehtafvizi54@gmail.com.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Tafvizi
authors.forename: Zahra Tahmasebi
authors.initials: ZT
authors.lastname: Fard
authors.forename: Reza
authors.initials: R
authors.lastname: Assareh
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000821:virology*; D000236:Adenoma / Q000473:pathology / Q000821:virology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics*; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D055815:Young Adult
chemical_list: D004279:DNA, Viral