title: NNMT: A Bad Actor in Fat Makes Good in Liver.
abstract: High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.
authors.affiliation: Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
authors.forename: Samuel A J
authors.initials: SA
authors.lastname: Trammell
authors.affiliation: Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Obesity Research & Education Initiative, Carver College of Medicine, University of Iowa, Iowa City, IA 52242. Electronic address: charles-brenner@uiowa.edu.
authors.forename: Charles
authors.initials: C
authors.lastname: Brenner
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D050903:Nicotinamide N-Methyltransferase / Q000502:physiology*; D056564:Sirtuin 1 / Q000502:physiology*
chemical_list: D050903:Nicotinamide N-Methyltransferase; D056564:Sirtuin 1