title: Does Polyethylene Glycol (PEG) Plus Ascorbic Acid Induce More Mucosal Injuries than Split-Dose 4-L PEG during Bowel Preparation?
abstract: OBJECTIVE
  The aims of this study were to compare the bowel-cleansing efficacy, patient affinity for the preparation solution, and mucosal injury between a split dose of polyethylene glycol (SD-PEG) and low-volume PEG plus ascorbic acid (LV-PEG+Asc) in outpatient scheduled colonoscopies.
  
  
  METHODS
  Of the 319 patients, 160 were enrolled for SDPEG, and 159 for LV-PEG+Asc. The bowel-cleansing efficacy was rated according to the Ottawa bowel preparation scale. Patient affinity for the preparation solution was assessed using a questionnaire. All mucosal injuries observed during colonoscopy were biopsied and histopathologically reviewed.
  
  
  RESULTS
  There was no significant difference in bowel cleansing between the groups. The LV-PEG+Asc group reported better patient acceptance and preference. There were no significant differences in the incidence or characteristics of the mucosal injuries between the two groups.
  
  
  CONCLUSIONS
  Compared with SD-PEG, LV-PEG+Asc exhibited equivalent bowel-cleansing efficacy and resulted in improved patient acceptance and preference. There was no significant difference in mucosal injury between SD-PEG and LV-PEG+Asc. Thus, the LV-PEG+Asc preparation could be used more effectively and easily for routine colonoscopies without risking significant mucosal injury.
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Min Sung
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Jongha
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Hyung Jun
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Jang
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Hee Rin
authors.initials: HR
authors.lastname: Joo
authors.affiliation: Department of Pathology, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Joon Hyuk
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Nae Yun
authors.initials: NY
authors.lastname: Heo
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Seung Ha
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Tae Oh
authors.initials: TO
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea.
authors.forename: Sung Yeon
authors.initials: SY
authors.lastname: Yang
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects*; D003113:Colonoscopy / Q000379:methods; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000293:injuries*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D017060:Patient Satisfaction; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects*; D011300:Preoperative Care / Q000009:adverse effects* / Q000379:methods; D011795:Surveys and Questionnaires; D014815:Vitamins / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D002400:Cathartics; D014815:Vitamins; D011092:Polyethylene Glycols; D001205:Ascorbic Acid
keywords: Ascorbic acid; Bowel preparation; Colonoscopy; Mucosal injury; Polyethylene glycols