title: Enzyme Relaxes Cortex of Mitotic Cells.
abstract: At the end of mitosis, the stiff actomyosin cortex at a cell's poles has to soften so that the cell can elongate and divide. The enzyme PP1, which sits on the kinetochores during metaphase and anaphase, spurs the polar cortex to relax. Polar relaxation is particularly important for cancer cells, and inhibiting it might rein in their division.
mesh_terms: D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008938:Mitosis; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism*