title: Longitudinal Changes in Serum Levels of Angiopoietin-Like Protein 6 and Selenoprotein P After Gastric Bypass Surgery.
abstract: BACKGROUND
  Bariatric surgery has beneficial effects on weight loss and metabolic profiles. Recent evidence suggests that liver-derived hepatokines play a role in the pathophysiology of metabolic diseases. However, few studies have reported longitudinal changes in hepatokines after gastric bypass surgery. We investigated changes in the serum levels of angiopoietin-like protein 6 (Angptl6) and selenoprotein P after gastric bypass surgery.
  
  
  METHODS
  We followed 10 patients who were treated with gastric bypass for weight loss. We measured metabolic parameters and the serum levels of Angptl6 and selenoprotein P before, 1 month after, and 9 months after surgery. We investigated the changes in those hepatokines after surgery and the associations between changes in Angptl6 and selenoprotein P, respectively, and metabolic parameters.
  
  
  RESULTS
  Body mass index decreased linearly. Levels of hemoglobin A1c (HbA1c), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT), total cholesterol, triglyceride, LDL cholesterol, and Angptl6 were significantly lower 1 and 9 months after surgery. Fasting plasma glucose was normal throughout the study. Fasting insulin decreased 1 month after surgery but increased 9 months post-surgery. Levels of selenoprotein P increased linearly. Significant correlations were detected between the levels of Angptl6 and LDL cholesterol and fasting insulin. Changes in Angptl6 levels were significantly correlated with changes in total cholesterol and LDL cholesterol. Selenoprotein P levels were inversely correlated with GGT, and changes in selenoprotein P were inversely correlated with changes in homeostasis model assessment for insulin resistance (HOMA-IR).
  
  
  CONCLUSIONS
  Our results suggest that gastric bypass may alter the serum levels of hepatokines independent of weight loss, and these changes are related to certain hepatic metabolic changes.
authors.affiliation: Department of Family Medicine, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Jisun
authors.initials: J
authors.lastname: Lim
authors.affiliation: Department of Family Medicine, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea. hyesoon@amc.seoul.kr.
authors.forename: Hye Soon
authors.initials: HS
authors.lastname: Park
authors.affiliation: Department of Physiology, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Seul Ki
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Physiology, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Yeon Jin
authors.initials: YJ
authors.lastname: Jang
authors.affiliation: Department of Family Medicine, College of Medicine, Inha University, 7-206, Sinheung-dong 3-Ga, Jung-gu, Incheon, 400-711, South Korea.
authors.forename: Yeon Ji
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of General Surgery, College of Medicine, Inha University, 7-206, Sinheung-dong 3-Ga, Jung-gu, Incheon, 400-711, South Korea. gshur@inha.ac.kr.
authors.forename: Yoonseok
authors.initials: Y
authors.lastname: Heo
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D015390:Gastric Bypass; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D051149:Selenoprotein P / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000410:Alanine Transaminase; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D001219:Aspartate Aminotransferases; D006442:Glycated Hemoglobin; D007328:Insulin; D051149:Selenoprotein P; D014280:Triglycerides; D005723:gamma-Glutamyltransferase; C477601:ANGPTL6 protein, human
keywords: Angiopoietin-like protein 6; Gastric bypass surgery; Hepatokine; Obesity; Selenoprotein P