title: Identifying differences between depressed adolescent suicide ideators and attempters.
abstract: BACKGROUND
  Adolescent depression and suicide are pressing public health concerns, and identifying key differences among suicide ideators and attempters is critical. The goal of the current study is to test whether depressed adolescent suicide attempters report greater anhedonia severity and exhibit aberrant effort-cost computations in the face of uncertainty.
  
  
  METHODS
  Depressed adolescents (n=101) ages 13-19 years were administered structured clinical interviews to assess current mental health disorders and a history of suicidality (suicide ideators=55, suicide attempters=46). Then, participants completed self-report instruments assessing symptoms of suicidal ideation, depression, anhedonia, and anxiety as well as a computerized effort-cost computation task.
  
  
  RESULTS
  Compared with depressed adolescent suicide ideators, attempters report greater anhedonia severity, even after concurrently controlling for symptoms of suicidal ideation, depression, and anxiety. Additionally, when completing the effort-cost computation task, suicide attempters are less likely to pursue the difficult, high value option when outcomes are uncertain. Follow-up, trial-level analyses of effort-cost computations suggest that receipt of reward does not influence future decision-making among suicide attempters, however, suicide ideators exhibit a win-stay approach when receiving rewards on previous trials.
  
  
  CONCLUSIONS
  Findings should be considered in light of limitations including a modest sample size, which limits generalizability, and the cross-sectional design.
  
  
  CONCLUSIONS
  Depressed adolescent suicide attempters are characterized by greater anhedonia severity, which may impair the ability to integrate previous rewarding experiences to inform future decisions. Taken together, this may generate a feeling of powerlessness that contributes to increased suicidality and a needless loss of life.
authors.affiliation: Department of Psychiatry, Harvard Medical School, Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA. Electronic address: rauerbach@mclean.harvard.edu.
authors.forename: Randy P
authors.initials: RP
authors.lastname: Auerbach
authors.affiliation: Department of Psychiatry, Harvard Medical School, Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA; Department of Psychology, Harvard University, Cambridge, MA, USA.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Millner
authors.affiliation: Department of Psychiatry, Harvard Medical School, Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
authors.forename: Jeremy G
authors.initials: JG
authors.lastname: Stewart
authors.affiliation: Department of Psychiatry, Harvard Medical School, Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
authors.forename: Erika C
authors.initials: EC
authors.lastname: Esposito
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D059445:Anhedonia; D001007:Anxiety / Q000523:psychology; D002755:Choice Behavior; D003430:Cross-Sectional Studies; D003863:Depression / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D012201:Reward; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000523:psychology*; D035501:Uncertainty; D055815:Young Adult
keywords: Adolescence; Anhedonia; Depression; Reward processing; Suicide