title: Reversible DNA i-motif to hairpin switching induced by copper(II) cations.
abstract: i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.
authors.affiliation: School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. z.waller@uea.ac.uk.
authors.forename: Henry Albert
authors.initials: HA
authors.lastname: Day
authors.forename: Elisé Patricia
authors.initials: EP
authors.lastname: Wright
authors.forename: Colin John
authors.initials: CJ
authors.lastname: MacDonald
authors.forename: Andrew James
authors.initials: AJ
authors.lastname: Gates
authors.forename: Zoë Ann Ella
authors.initials: ZA
authors.lastname: Waller
mesh_terms: D002412:Cations; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004492:Edetic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D059372:Nucleotide Motifs; D012996:Solutions
chemical_list: D002412:Cations; D012996:Solutions; D003300:Copper; D004247:DNA; D004492:Edetic Acid