title: Usefulness of multiple frequency band source localizations in ictal MEG.
abstract: OBJECTIVE
  We evaluated the diagnostic value of multiple frequency band MEG source localization within a wide time window during the preictal period.
  
  
  METHODS
  Data for 13 epilepsy patients who showed an ictal event during MEG were analyzed. Several seconds of preictal data were localized in the theta, alpha, beta, and gamma bands by using wavelet transformation and the sLORETA algorithm. The same analysis was performed with narrow time and frequency band. Localization concordances to the surgically resected area were compared.
  
  
  RESULTS
  Source localization in the gamma band for a 10s window before ictal onset showed best concordance to the resection cavity. Eight of 13 patients showed sub-lobar concordance in the 10s gamma band localization, whereas 3 showed concordance in the narrow time and frequency analysis. Four of 7 patients with focal cortical dysplasia (FCD) achieved seizure-free outcome, and all 4 showed sub-lobar concordance.
  
  
  CONCLUSIONS
  A 10s time window gamma source localization method can be used to delineate the epileptogenic zone.
  
  
  CONCLUSIONS
  The use of a long period during preictal gamma source localization has the potential to become a localizing biomarker of the epileptogenic zone in candidates for surgical intervention, especially in MRI-suspected FCD.
authors.affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea; Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Science, Seoul, South Korea. Electronic address: woorimjeong@gmail.com.
authors.forename: Woorim
authors.initials: W
authors.lastname: Jeong
authors.affiliation: Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea. Electronic address: junesic.kim@gmail.com.
authors.forename: June Sic
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea; Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Science, Seoul, South Korea; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea; Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, South Korea. Electronic address: chungc@snu.ac.kr.
authors.forename: Chun Kee
authors.initials: CK
authors.lastname: Chung
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D065818:Gamma Rhythm / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D054220:Malformations of Cortical Development / Q000175:diagnosis / Q000503:physiopathology; D055815:Young Adult
keywords: Epilepsy; Gamma; Ictal; Magnetoencephalography; Source localization