title: Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets.
abstract: Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Sylvia T
authors.initials: ST
authors.lastname: Gunawan
authors.affiliation: Department of Chemistry, University of Warwick, CV 4 7AL, Coventry, UK.
authors.forename: Kristian
authors.initials: K
authors.lastname: Kempe
authors.affiliation: Vascular Biotechnology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bonnard
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Jiwei
authors.initials: J
authors.lastname: Cui
authors.affiliation: Vascular Biotechnology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
authors.forename: Karen
authors.initials: K
authors.lastname: Alt
authors.affiliation: Vascular Biotechnology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
authors.forename: Lok S
authors.initials: LS
authors.lastname: Law
authors.affiliation: Atherothrombosis and Vascular Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Atherothrombosis and Vascular Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
authors.forename: Erik
authors.initials: E
authors.lastname: Westein
authors.affiliation: Department of Chemistry, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Georgina K
authors.initials: GK
authors.lastname: Such
authors.affiliation: Atherothrombosis and Vascular Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Peter
authors.affiliation: Vascular Biotechnology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
authors.forename: Christoph E
authors.initials: CE
authors.lastname: Hagemeyer
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D000595:Amino Acid Sequence; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology*; D002214:Capsules; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry; D010080:Oxazoles / Q000737:chemistry*; D015539:Platelet Activation / Q000187:drug effects*; D013917:Thrombin / Q000378:metabolism*; D013927:Thrombosis / Q000503:physiopathology; D014568:Urokinase-Type Plasminogen Activator / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D002214:Capsules; D004337:Drug Carriers; D009842:Oligopeptides; D010080:Oxazoles; C577913:poly(2-oxazoline); C047981:arginyl-glycyl-aspartic acid; D013917:Thrombin; D014568:Urokinase-Type Plasminogen Activator
keywords: antibodies; drug delivery; plasminogen activators; polymer carriers; thrombosis