title: Liver resection for ovarian cancer liver metastases as part of cytoreductive surgery is safe and may bring survival benefit.
abstract: BACKGROUND
  The aim of this study was to evaluate whether hepatic resections of ovarian cancer liver metastases provide a benefit in terms of survival as part of primary, secondary, tertiary, and even quaternary cytoreductive surgery.
  
  
  METHODS
  Data of patients submitted to surgery for ovarian cancer liver metastases at Fundeni Clinical Institute between January 2002 and April 2014 were retrospectively reviewed. Liver lesions were classified according to their origin in parenchymal and peritoneal lesions.
  
  
  RESULTS
  A total of 31 patients were identified: 11 of them underwent liver resection as part of primary cytoreduction, 15 at secondary cytoreduction, 3 at tertiary cytoreduction, and 2 at the time of quaternary cytoreduction. The survival of patients with primary cytoreduction including liver resection was significantly higher compared with that of patients with secondary cytoreductive surgery including liver resection (15.63 versus 6.63 months, log-rank p=0.057, 90% CI). The median survival of patients with hepatectomy for liver metastases from peritoneal seeding was higher than that of patients with hepatectomy for liver metastases from hematogenous origin (16.08 versus 12.66 months, log-rank p=0.523).
  
  
  CONCLUSIONS
  Hepatectomy in ovarian cancer liver metastases is a safe and effective procedure; however, a benefit in terms of survival in favor of peritoneal seeding has been systematically observed.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, Bucharest, 050474, Romania. nicolaebacalbasa@gmail.com.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Bacalbasa
authors.affiliation: "Dan Setlacec" Center of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Soseaua Fundeni 258, Bucharest, 022328, Romania. dima.simona@gmail.com.
authors.forename: Simona
authors.initials: S
authors.lastname: Dima
authors.affiliation: "Dan Setlacec" Center of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Soseaua Fundeni 258, Bucharest, 022328, Romania. brasoveanuvlad@yahoo.com.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Brasoveanu
authors.affiliation: "Dan Setlacec" Center of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Soseaua Fundeni 258, Bucharest, 022328, Romania. leodavid02@yahoo.com.
authors.forename: Leonard
authors.initials: L
authors.lastname: David
authors.affiliation: "Ponderas" Hospital, Bucharest, Romania. irina_balescu206@yahoo.com.
authors.forename: Irina
authors.initials: I
authors.lastname: Balescu
authors.affiliation: Department of Mathematical Methods and Models, Faculty of Applied Sciences, Politehnica University of Bucharest, Splaiul Independentei nr. 313, RO-060042, Bucharest, Romania. raluca.purtan@gmail.com.
authors.forename: Raluca
authors.initials: R
authors.lastname: Purnichescu-Purtan
authors.affiliation: "Dan Setlacec" Center of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Soseaua Fundeni 258, Bucharest, 022328, Romania. irinel.popescu220@gmail.com.
authors.forename: Irinel
authors.initials: I
authors.lastname: Popescu
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D018284:Cystadenocarcinoma, Serous / Q000401:mortality / Q000473:pathology / Q000601:surgery; D065426:Cytoreduction Surgical Procedures / Q000401:mortality*; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000401:mortality*; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate