title: Serum Gamma-Glutamyltransferase Levels Predict Mortality in Patients With Peritoneal Dialysis.
abstract: Serum gamma-glutamyltransferase (GGT) level has been considered marker of oxidative stress as well as liver function. Serum GGT level has been reported to be associated with the mortality in hemodialysis patients. However, it is not well established whether serum GGT level is associated with all-cause mortality in peritoneal dialysis (PD) patients. The aim of this study was to determine the association between serum GGT levels and all-cause mortality in PD patients.PD patients were included from the Clinical Research Center registry for end-stage renal disease cohort, a multicenter prospective observational cohort study in Korea. Patients were categorized into 3 groups by tertile of serum GGT levels as follows: tertile 1, GGT < 16 IU/L; tertile 2, GGT = 16 to 27 IU/L; and tertile 3, GGT > 27 IU/L. Primary outcome was all-cause mortality.A total of 820 PD patients were included. The median follow-up period was 34 months. Kaplan-Meier analysis showed that the all-cause mortality rate was significantly different according to tertiles of GGT (P = 0.001, log-rank). The multivariate Cox regression analysis showed that higher tertiles significantly associated with higher risk for all-cause mortality (tertile 2: hazard ratio [HR] 2.08, 95% confidence interval [CI], 1.17-3.72, P = 0.013; tertile 3: HR 1.83, 95% CI, 1.04-3.22, P = 0.035) in using tertile 1 as the reference group after adjusting for clinical variables.Our study demonstrated that high serum GGT levels were an independent risk factor for all-cause mortality in PD patients. Our findings suggest that serum GGT levels might be a useful biomarker to predict all-cause mortality in PD patients.
authors.affiliation: From the Department of Internal Medicine (W-YP, YOK, DCJ, HCS, EJC, CWY, YKK), College of Medicine, The Catholic University of Korea, Seoul; Department of Internal Medicine (S-HK), College of Medicine, Chung-Ang University, Seoul; Department of Internal Medicine (YLK), School of Medicine, Kyungpook National University, Daegu; Department of Internal Medicine (YSK), College of Medicine, Seoul National University, Seoul; Department of Internal Medicine (SWK), College of Medicine, Yonsei University, Seoul; Department of Internal Medicine (NHK), Chonnam National University Medical School, Gwangju; and Cell Death Disease Research Center (YKK), College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Woo-Yeong
authors.initials: WY
authors.lastname: Park
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Kim
authors.forename: Dong Chan
authors.initials: DC
authors.lastname: Jin
authors.forename: Ho Chul
authors.initials: HC
authors.lastname: Song
authors.forename: Euy Jin
authors.initials: EJ
authors.lastname: Choi
authors.forename: Yong Lim
authors.initials: YL
authors.lastname: Kim
authors.forename: Yon Su
authors.initials: YS
authors.lastname: Kim
authors.forename: Shin Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Nam Ho
authors.initials: NH
authors.lastname: Kim
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Yang
authors.forename: Yong Kyun
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000097:blood / Q000201:enzymology / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000401:mortality*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D015996:Survival Rate; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human