title: Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants.
abstract: We describe a new, versatile synthetic approach to Quillaja saponin variants based on the natural product immunoadjuvant QS-21. This modular, divergent strategy provides efficient access to linear oligosaccharide domain variants with modified sugars and regiochemistries. This new synthetic approach opens the door to the rapid generation of diverse analogues to identify novel saponin adjuvants with improved synthetic accessibility.
authors.affiliation: Chemical Biology Program, Memorial Sloan Kettering Cancer Center, 1 275 York Avenue, New York, NY 10065, USA. alberto.fernandezt@gmail.com.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández-Tejada
authors.affiliation: Chemical Biology Program, Memorial Sloan Kettering Cancer Center, 1 275 York Avenue, New York, NY 10065, USA. alberto.fernandezt@gmail.com.|Tri-Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1 275 York Avenue, New York, NY 10065, USA. tand@mskcc.org.
authors.forename: Derek S
authors.initials: DS
authors.lastname: Tan
authors.affiliation: Chemical Biology Program, Memorial Sloan Kettering Cancer Center, 1 275 York Avenue, New York, NY 10065, USA. alberto.fernandezt@gmail.com.|Tri-Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1 275 York Avenue, New York, NY 10065, USA. tand@mskcc.org.
authors.forename: David Y
authors.initials: DY
authors.lastname: Gin
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry*; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry*; D031990:Quillaja; D012503:Saponins / Q000737:chemistry*; D014612:Vaccines
chemical_list: D000276:Adjuvants, Immunologic; D009844:Oligosaccharides; D012503:Saponins; D014612:Vaccines; C078785:saponin QA-21V1