title: Targeting aggressive cancers with an artificial sweetener: could saccharin be a lead compound in anticancer therapy?
authors.affiliation: Department of Biochemistry & Molecular Biology, College of Medicine, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Mahon
authors.affiliation: Department of Biochemistry & Molecular Biology, College of Medicine, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, USA.
authors.forename: Cynthia O
authors.initials: CO
authors.lastname: Okoh
authors.affiliation: Department of Biochemistry & Molecular Biology, College of Medicine, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: McKenna
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D012439:Saccharin / Q000627:therapeutic use*; D013549:Sweetening Agents / Q000627:therapeutic use
chemical_list: D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D013549:Sweetening Agents; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases; C477378:carbonic anhydrase XII; D012439:Saccharin
keywords: anticancer therapies; carbonic anhydrase IX and XII; saccharin; tumor hypoxia