title: Does increasing applied load lead to contact changes indicative of knee osteoarthritis? A subject-specific FEA study.
abstract: This study investigated whether increased loading (representing obesity) in the extended knee and flexed knee led to increased stresses in areas of typical medial and lateral osteoarthritis cartilage lesions, respectively. We created two paired sets of subject-specific finite element models; both sets included models of extended knees and of flexed knees. The first set represented normal loading; the second set represented increased loading. All other variables were held constant. The von Mises stresses and contact areas calculated on the tibial cartilage surfaces of the paired models were then compared. In the extended knee models, applying a larger load led to increased stress in the anterior and central regions of the medial tibial cartilage. These are the typical locations of medial osteoarthritis cartilage lesions. Therefore, the results support that increased loading in the extended knee may result in medial osteoarthritis. In the flexed knee models, applying a larger load increased stress in the anterior and central regions of the lateral tibial cartilage. Lateral osteoarthritis cartilage lesions typically occur centrally and posteriorly. Therefore, these results do not support our hypothesis. Shear stress was increased in areas of typical lateral lesions, however, and should be investigated in future studies.
authors.affiliation: Department of Engineering Science, University of Oxford, Oxford, UK.|Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Boyd
authors.affiliation: Department of Engineering Science, University of Oxford, Oxford, UK.
authors.forename: Amy B
authors.initials: AB
authors.lastname: Zavatsky
authors.affiliation: Department of Mechanical Engineering, University of Bath, Bath, UK.
authors.forename: Harinderjit S
authors.initials: HS
authors.lastname: Gill
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D020370:Osteoarthritis, Knee / Q000503:physiopathology*; D013314:Stress, Mechanical; D016474:Weight-Bearing; D055815:Young Adult
keywords: finite element analysis; knee joint contact mechanics; obesity; patient-specific modelling; tibiofemoral flexion angles; unicompartmental knee osteoarthritis