title: [Severe Caffeine Intentional Intoxication and Delayed Elimination: a Case Report].
abstract: We report a massive intoxication by caffeine (20 g) with positive clinical evolution despite potentially lethal plasma concentrations (244 µg/mL) and delayed elimination.
authors.affiliation: Service de Pharmacologie Clinique, CHU Timone, AP-HM, Marseille, France.
authors.forename: Mélody
authors.initials: M
authors.lastname: Barreau
authors.affiliation: Service de Pharmacologie Clinique, CHU Timone, AP-HM, Marseille, France.
authors.forename: Bérengère
authors.initials: B
authors.lastname: Lambert
authors.affiliation: Service de Réanimation Urgences et Médicale, CHU Timone, AP-HM, Marseille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Tobarias
authors.affiliation: Service de Réanimation Urgences et Médicale, CHU Timone, AP-HM, Marseille, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Lambert
authors.affiliation: Service de Pharmacologie Clinique, CHU Timone, AP-HM, Marseille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Dupouey
authors.affiliation: Service de Pharmacologie Clinique, CHU Timone, AP-HM, Marseille, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Blin
authors.affiliation: Service de Pharmacologie Clinique, CHU Timone, AP-HM, Marseille, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Guilhaumou
mesh_terms: D000138:Acidosis / Q000139:chemically induced; D058186:Acute Kidney Injury / Q000139:chemically induced; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002110:Caffeine / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004554:Electric Countershock; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced; D008297:Male; D008657:Metabolic Clearance Rate; D011412:Propanolamines / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000139:chemically induced*; D013406:Suicide, Attempted; D013806:Theophylline / Q000493:pharmacokinetics; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000628:therapy; D055815:Young Adult
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D002110:Caffeine; D013806:Theophylline; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2; C036604:esmolol; C021183:1,7-dimethylxanthine