title: The Possible Future Roles for iPSC-Derived Therapy for Autoimmune Diseases.
abstract: The ability to generate inducible pluripotent stem cells (iPSCs) and the potential for their use in treatment of human disease is of immense interest. Autoimmune diseases, with their limited treatment choices are a potential target for the clinical application of stem cell and iPSC technology. IPSCs provide three potential ways of treating autoimmune disease; (i) providing pure replacement of lost cells (immuno-reconstitution); (ii) through immune-modulation of the disease process in vivo; and (iii) for the purposes of disease modeling in vitro. In this review, we will use examples of systemic, system-specific and organ-specific autoimmunity to explore the potential applications of iPSCs for treatment of autoimmune diseases and review the evidence of iPSC technology in auto-immunity to date.
authors.affiliation: Department of Clinical Immunology, Pathwest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth 6009, Western Australia, Australia. Meilyn.Hew@health.wa.gov.au.
authors.forename: Meilyn
authors.initials: M
authors.lastname: Hew
authors.affiliation: Department of Clinical Immunology, Royal Perth Hospital, Perth 6000, Western Australia, Australia. Connor@health.wa.gov.au.
authors.forename: Kevin
authors.initials: K
authors.lastname: O'Connor
authors.affiliation: Control of Pluripotency Laboratory, Department of Physiological Sciences I, Faculty of Medicine, University of Barcelona, Hospital Clinic, Casanova 143, Barcelona 08036, Spain. Edel.Michael@gmail.com.|Victor Chang Cardiac Research Institute, Sydney, 2010, New South Wales, Australia. Edel.Michael@gmail.com.|School of Medicine and Pharmacology, Anatomy, Physiology and Human Biology, CCTRM, University of Western Australia, Perth, 6009, Western Australia, Australia. Edel.Michael@gmail.com.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Edel
authors.affiliation: Department of Clinical Immunology, Pathwest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth 6009, Western Australia, Australia. Michaela.Lucas@health.wa.gov.au.|School of Medicine and Pharmacology and School of Pathology and Laboratory Medicine, The University of Western Australia, Harry Perkins Institute of Medical Research, Perth, 6009, Western Australia, Australia. Michaela.Lucas@health.wa.gov.au.|Institute for Immunology and Infectious Diseases, Murdoch University, Perth, 6150, Western Australia. Michaela.Lucas@health.wa.gov.au.
authors.forename: Michaela
authors.initials: M
authors.lastname: Lucas
keywords: autoimmunity; diabetes; inducible; lupus; multiple sclerosis; pluripotent; stem cells; therapy