title: [Intra cranial meningiomas and long term use of cyproterone acetate with a conventional dose in women. A report of two cases of tumor decrease after treatment withdrawal].
abstract: The action of synthetic progestogens, prescribed at a conventional dose in women, for a meningioma, is still poorly understood, and could be related to progesterone receptors. We report two cases illustrating multiple meningiomas with stabilization or tumor reduction after withdrawal of cyproterone acetate originally prescribed for a long term period. We also review the influence of synthetic progestogens on meningiomas, particularly the impact of treatment withdrawal.
authors.affiliation: Service de neurochirurgie, hôpital Gabriel-Montpied, CHU de Clermont-Ferrand, 58, rue Montalembert, 63003 Clermont-Ferrand, France. Electronic address: celine-bc@hotmail.fr.
authors.forename: C
authors.initials: C
authors.lastname: Botella
authors.affiliation: Service de neurochirurgie, hôpital Gabriel-Montpied, CHU de Clermont-Ferrand, 58, rue Montalembert, 63003 Clermont-Ferrand, France.
authors.forename: G
authors.initials: G
authors.lastname: Coll
authors.affiliation: EA 7282 IGCNC (Image-Guided Clinical Neuroscience and Connectomics) Clermont université, université d'Auvergne, UFR Médecine, 63000 Clermont-Ferrand, France; Service de neurochirurgie, hôpital Gabriel-Montpied, CHU de Clermont-Ferrand, 58, rue Montalembert, 63003 Clermont-Ferrand, France.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Lemaire
authors.affiliation: EA 7282 IGCNC (Image-Guided Clinical Neuroscience and Connectomics) Clermont université, université d'Auvergne, UFR Médecine, 63000 Clermont-Ferrand, France; Service de neurochirurgie, hôpital Gabriel-Montpied, CHU de Clermont-Ferrand, 58, rue Montalembert, 63003 Clermont-Ferrand, France.
authors.forename: B
authors.initials: B
authors.lastname: Irthum
mesh_terms: D000328:Adult; D003534:Cyproterone / Q000494:pharmacology*; D017373:Cyproterone Acetate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008579:Meningioma / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D017373:Cyproterone Acetate; D003534:Cyproterone
keywords: Acétate de cyprotérone; Cyproterone acetate; Exogenous sex hormone; Hormone sexuelle exogène; Meningioma; Méningiome; Progestatif de synthèse; Synthetic progestogens