title: Update: Rationale and design of the Sodium Lowering In Dialysate (SoLID) trial: a randomised controlled trial of low versus standard dialysate sodium concentration during hemodialysis for regression of left ventricular mass.
abstract: After the publication of our paper Dunlop et al. "Rationale and design of the Sodium Lowering In Dialysate (SoLID) trial: a randomised controlled trial of low versus standard dialysate sodium concentration during hemodialysis for regression of left ventricular mass", we became aware of further data correlating left ventricular (LV) mass index at baseline and their corresponding mass at 12 months, using cardiac magnetic resonance imaging (MRI) in patients on hemodialysis. The original published sample size for the SoLID trial of 118 was a conservative estimate, calculated using analysis of covariance and a within person Pearson's correlation for LV mass index of 0.75. New data communicated to the SoLID trial group has resulted in re-calcuation of the sample size, based upon a within person Pearson's correlation of 0.8 but otherwise unchanged assumptions. As a result, the SoLID trial will now recruit 96 participants.
authors.affiliation: Auckland Clinical School, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand. Joanna.Dunlop@middlemore.co.nz.|Department of Renal Medicine, Middlemore Hospital, Counties Manukau District Health Board, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand. Joanna.Dunlop@middlemore.co.nz.
authors.forename: Joanna Leigh
authors.initials: JL
authors.lastname: Dunlop
authors.affiliation: Faculty of Health and Environmental Sciences, Auckland University of Technology, North Shore Campus, Private Bag 92006, Auckland, 1142, New Zealand. alain.vandal@aut.ac.nz.|Ko Awatea, Middlemore Hospital, Counties Manukau District Health Board, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand. alain.vandal@aut.ac.nz.
authors.forename: Alain Charles
authors.initials: AC
authors.lastname: Vandal
authors.affiliation: Renal Service, North Shore Hospital, Waitemata District Health Board, Private Bag 93503, Takapuna, Auckland, 0740, New Zealand. Janak.deZoysa@waitematadhb.govt.nz.
authors.forename: Janak Rashme
authors.initials: JR
authors.lastname: de Zoysa
authors.affiliation: Department of Cardiology, Middlemore Hospital, Counties Manukau District Health Board, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand. ruvin.gabriel@middlemore.co.nz.
authors.forename: Ruvin Sampath
authors.initials: RS
authors.lastname: Gabriel
authors.affiliation: Bathurst Health Service, New South Wales, Australia. ihaloob@gmail.coml.
authors.forename: Imad Adbi
authors.initials: IA
authors.lastname: Haloob
authors.affiliation: Department of Renal Medicine, Middlemore Hospital, Counties Manukau District Health Board, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand. Chris.Hood@middlemore.co.nz.
authors.forename: Christopher John
authors.initials: CJ
authors.lastname: Hood
authors.affiliation: Department of Nephrology, Wellington Hospital, Capital & Coast District Health Board, Private Bag 7902, Wellington South, New Zealand. philip.Matheson@ccdhb.org.nz.
authors.forename: Philip James
authors.initials: PJ
authors.lastname: Matheson
authors.affiliation: Department of Nephrology, Christchurch Hospital, Canterbury District Health Board, Private Bag 4710, Christchurch, New Zealand. David.McGregor@cdhb.govt.nz.
authors.forename: David Owen Ross
authors.initials: DO
authors.lastname: McGregor
authors.affiliation: Department of Renal Medicine, Waikato Hospital, Waikato District Health Board, Private Bag 3200, Hamilton, 3240, New Zealand. K.Rabindranath@waikatodhb.health.nz.
authors.forename: Kannaiyan Samuel
authors.initials: KS
authors.lastname: Rabindranath
authors.affiliation: Department of Renal Medicine, Auckland City Hospital, Auckland District Health Board, Private Bag 92024, Auckland, Auckland, 0740, New Zealand. DSemple@adhb.govt.nz.
authors.forename: David John
authors.initials: DJ
authors.lastname: Semple
authors.affiliation: Auckland Clinical School, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand. mrmarsh@woosh.co.nz.|Department of Renal Medicine, Middlemore Hospital, Counties Manukau District Health Board, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand. mrmarsh@woosh.co.nz.|Medical Affairs - Renal (Asia Pacific), Baxter Healthcare, P.O. Box 14062, Panmure, Auckland, 1741, New Zealand. mrmarsh@woosh.co.nz.
authors.forename: Mark Roger
authors.initials: MR
authors.lastname: Marshall
mesh_terms: D015314:Dialysis Solutions / Q000737:chemistry*; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009929:Organ Size; D006435:Renal Dialysis; D012107:Research Design; D018401:Sample Size; D012964:Sodium / Q000008:administration & dosage*
chemical_list: D015314:Dialysis Solutions; D012964:Sodium