title: Evaluation of affective temperament and anxiety-depression levels of patients with polycystic ovary syndrome.
abstract: BACKGROUND
  Women with polycystic ovary syndrome (PCOS) are reported to experience depressive episodes at a higher rate than healthy controls (HC). Affective temperament features are psychiatric markers that may help to predict and identify vulnerability to depression in women with PCOS. Our aim was to evaluate the affective temperaments of women with PCOS and to investigate the association with depression and anxiety levels and laboratory variables in comparison with HC.
  
  
  METHODS
  The study included 71 women with PCOS and 50 HC. Hormonal evaluations were performed for women with PCOS. Physical examination, clinical history, Hospital Anxiety and Depression Scale (HADS) and TEMPS-A were performed for all subjects. Differences between groups were evaluated using Student's t-tests and Mann-Whitney U tests. Correlations and logistic regression tests were performed.
  
  
  RESULTS
  All temperament subtype scores, except hyperthymic, and HADS anxiety, depression, and total scores were significantly higher in patients with PCOS compared to HC. A statistically significant positive correlation was found between BMI and irritable temperament, and insulin and HADS depression scores in patients with PCOS. Additionally, hirsutism score and menstrual irregularity were correlated with HADS depression, anxiety and total scores in PCOS patients. In logistic regression analysis, depression was not affected by PCOS, hirsutism score or menstrual irregularity. However, HADS anxiety score was associated with hirsutism score.
  
  
  CONCLUSIONS
  Our study is the first to evaluate the affective temperament features of women with PCOS. Consequently, establishing affective temperament properties for women with PCOS may help clinicians predict those patients with PCOS who are at risk for depressive and anxiety disorders.
authors.affiliation: Departments of Endocrinology and Metabolism, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. Electronic address: mehmetzu@yahoo.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Asik
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Kursat
authors.initials: K
authors.lastname: Altinbas
authors.affiliation: Departments of Endocrinology and Metabolism, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Eroglu
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Karaahmet
authors.affiliation: General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Erbag
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Ertekin
authors.affiliation: General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Hacer
authors.initials: H
authors.lastname: Sen
mesh_terms: D000328:Adult; D000339:Affect; D001007:Anxiety / Q000175:diagnosis* / Q000209:etiology; D003863:Depression / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000523:psychology*; D012720:Severity of Illness Index; D013694:Temperament
keywords: Affective temperament; Anxiety; Depression; Hirsutism; PCOS; Polycystic ovary syndrome