title: RB-loss puts focus on Myc.
abstract: Activator E2Fs and Myc cooperate as master regulators of proliferation. A new study sheds light on one of the fundamental questions in cancer biology: how do oncogenic changes, such as Retinoblastoma (RB)-mutation, modify E2F and Myc activity?
authors.affiliation: Harvard Medical School Laboratory of Molecular Oncology The MGH Cancer Center, Bldg 149, 13th Street Charlestown, Massachusetts 02129, USA.
authors.forename: Wayne O
authors.initials: WO
authors.lastname: Miles
authors.affiliation: Harvard Medical School Laboratory of Molecular Oncology The MGH Cancer Center, Bldg 149, 13th Street Charlestown, Massachusetts 02129, USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Dyson
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints; D049109:Cell Proliferation; D050684:E2F Transcription Factors / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000172:deficiency*
chemical_list: D050684:E2F Transcription Factors; D016271:Proto-Oncogene Proteins c-myc; D016160:Retinoblastoma Protein