title: Cytotoxic 19-oxygenated steroids from the South China Sea gorgonian, Pacifigorgia senta.
abstract: Bioassay guided chemical investigation of the gorgonian Pacifigorgia senta led to the discovery of a new 19-oxygenated steroid, cholesta-5,24-diene-3β,7β,19-triol (1), as well as three known steroids (2-4). The structure of 1 was determined by extensive spectroscopic analysis, including NMR and MS spectra. All of the compounds exhibited cytotoxicities against HepG2, Hep3B, MCF-7/ADR, PC-3 and HCT-116 cell lines, with the IC50 values ranging from 7.0 to 29.7 μM. It is the first report on the chemical constituents of the coral species P. senta.
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009792:Oceans and Seas; D010100:Oxygen / Q000737:chemistry; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013256:Steroids; C000619292:cholesta-5,24-diene-3beta,7beta,19-triol; D010100:Oxygen
keywords: 19-oxygenated steroid; Gorgonian; Pacifigorgia senta; cytotoxicity