title: The promise of zebrafish as a chemical screening tool in cancer therapy.
abstract: Cancer progression in zebrafish recapitulates many aspects of human cancer and as a result, zebrafish have been gaining popularity for their potential use in basic and translational cancer research. Human cancer can be modeled in zebrafish by induction using chemical mutagens, xenotransplantation or by genetic manipulation. Chemical screens based on zebrafish cancer models offer a rapid, powerful and inexpensive means of evaluating the potential of suppression or prevention on cancer. The identification of small molecules through such screens will serve as ideal entry points for novel chemical therapies for cancer treatment. This article outlines advances that have been made within the growing field of zebrafish cancer models and presents their advantages for chemical drug screening.
authors.affiliation: Cancer Center, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA.
authors.forename: Xiayang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Chemistry, Berry College, 2277 Martha Berry Highway, Mount Berry, GA 30149, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Ross
authors.affiliation: Cancer Center, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA.
authors.forename: John K
authors.initials: JK
authors.lastname: Cowell
authors.affiliation: Cancer Center, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA.|Department of Biochemistry & Molecular Biology, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Teng
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D057170:Translational Research, Biomedical; D015027:Zebrafish / Q000502:physiology