title: Genetic variability of ten Chinese indigenous goats using MHC-linked microsatellite markers.
abstract: In this study, the genetic variability of Chinese indigenous goat breeds (Capra hircus) was analyzed using the MHC-associated microsatellite markers BF1, BM1818, BM1258, and DYMS1. To examine genetic variability, the levels of heterozigosity, degrees of inbreeding, and genetic differences among the breeds were analyzed. The mean number of alleles ranged from 5.50±3.70 in Enshi black goats (EB) to 11.50±3.70 in the Jianyang big ear (JE) breed. The mean observed heterozygosity and mean expected heterozygosity varied from 0.25±0.04 in Jining Qing goats (JQ) to 0.54±0.05 in Chuannan black goats (CN) and from 0.49±0.18 in Hechuan white goats (HW) to 0.78±0.05 in JE, respectively. The mean FIS values ranged from 0.23 in HW to 0.51 in JQ. In addition, the genetic variation among populations and geographic location did indicate a correlation of genetic differences with geographic distance, which was revealed by the phylogenetic network. In conclusion, the high variability and population structure among Chinese native goats in the Major Histocompatibility Complex would be caused by co-evolution between MHC alleles and the epidemic history or pathogens in different agro-ecological zones.
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing 400716, China.
authors.forename: Guang-Xin
authors.initials: GX
authors.lastname: E
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing 400716, China. Electronic address: H67738337@swu.edu.cn.
authors.forename: Yong-Fu
authors.initials: YF
authors.lastname: Huang
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing 400716, China.
authors.forename: Yong-Ju
authors.initials: YJ
authors.lastname: Zhao
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China.
authors.forename: Yue-Hui
authors.initials: YH
authors.lastname: Ma
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing 400716, China.
authors.forename: Ri-Su
authors.initials: RS
authors.lastname: Na
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing 400716, China.
authors.forename: Jia-Hua
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China.
authors.forename: Hui-Jiang
authors.initials: HJ
authors.lastname: Gao
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing 400716, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
mesh_terms: D000483:Alleles; D000818:Animals; D001947:Breeding; D002681:China; D019143:Evolution, Molecular; D014644:Genetic Variation; D005828:Genetics, Population; D006041:Goats / Q000235:genetics* / Q000276:immunology*; D006579:Heterozygote; D008285:Major Histocompatibility Complex; D018895:Microsatellite Repeats; D010802:Phylogeny; D011110:Polymorphism, Genetic
keywords: Diversity; Indigenous goats; Major Histocompatibility Complex (MHC); Microsatellite