title: A new sesquiterpenoid quinone with cytotoxicity from Abelmoschus sagittifolius.
abstract: A new sesquiterpenoid quinone, Acyl hibiscone B (1), together with five known compounds, (R)-lasiodiplodin (2), (R)-de-O-methyllasiodiplodin, (3) dibutyl phthalate (4), (R)-9-phenylnonan-2-ol (5) and hibiscone B (6), was obtained from the stem tuber of Abelmoschus sagittifolius. The structure of compound 1 was elucidated by analysing its (1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC, NOESY and HR-ESI-MS values. Compound 1 showed significant cytotoxicity against Hela and HepG-2 human cancer cell lines.
authors.affiliation: a Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine) , Chinese Academy of Medical Sciences & Peking Union Medical College , Wanning 571533 , P.R. China.
authors.forename: De-Li
authors.initials: DL
authors.lastname: Chen
authors.affiliation: b School of Pharmaceutical Science , Hainan Medical University , No.3 Xueyuan Road, Longhua District, Haikou 571101 , P.R. China.
authors.forename: Xiao-Po
authors.initials: XP
authors.lastname: Zhang
authors.affiliation: c Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College , No. 151, Malianwa North Road, Haidian District, Beijing 100193 , P.R. China.
authors.forename: Guo-Xu
authors.initials: GX
authors.lastname: Ma
authors.affiliation: c Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College , No. 151, Malianwa North Road, Haidian District, Beijing 100193 , P.R. China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.affiliation: c Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College , No. 151, Malianwa North Road, Haidian District, Beijing 100193 , P.R. China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
authors.affiliation: c Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College , No. 151, Malianwa North Road, Haidian District, Beijing 100193 , P.R. China.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
mesh_terms: D028483:Abelmoschus / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D018517:Plant Roots / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D011809:Quinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000081223:Polycyclic Sesquiterpenes; D011809:Quinones; D012717:Sesquiterpenes; C000610670:acyl hibiscone B
keywords: Abelmoschus sagittifolius; cytotoxicity; sesquiterpenoid