title: Nutridynamics: mechanism(s) of action of bioactive compounds and their effects.
abstract: Mechanism of action of bioactive compounds may be multiple, especially in the food matrix. Therefore, the interplay between these compounds and hosts' physiology, and the consequences of its continuous intake should be considered. In analogy with pharmacodynamics, the bioactive compounds should have both defined targets and mechanisms of action. However, several essential differences arise when considering the heterogeneous nature of the food matrix, the multiplicity of mechanisms and the variety of responses. In order to ascertain a potential mechanism of activity, one should consider both the intended use of the food, the biomarker that will support this claim and previous evidences, examined from current information sources. Once these have been examined, several experimental strategies should be considered, ranging from the choice of preclinical or experimental model, the use of samples from pilot interventional studies and the application of system's biology derived techniques, such as transcriptomics or metabolomics.
authors.affiliation: Departament de Medicina Experimental, NUTREN-Nutrigenomics, Metabolic Pathophysiology Research Group, PCiTAL-IRBLleida-Universitat de Lleida , Spain.
authors.forename: Jose C E
authors.initials: JC
authors.lastname: Serrano
authors.forename: Mariona
authors.initials: M
authors.lastname: Jove
authors.forename: Hugo
authors.initials: H
authors.lastname: Gonzalo
authors.forename: Reinald
authors.initials: R
authors.lastname: Pamplona
authors.forename: Manuel
authors.initials: M
authors.lastname: Portero-Otin
mesh_terms: D000818:Animals; D001682:Biological Availability; D015415:Biomarkers; D005502:Food; D005504:Food Analysis / Q000379:methods*; D006801:Humans; D055432:Metabolomics / Q000379:methods; D054647:Nutrigenomics / Q000379:methods; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D052756:Nutritional Sciences / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Lipidomics; mechanism of action; metabolomics; mitochondria; soy