title: Hepatic and visceral adipose tissue 11βHSD1 expressions are markers of body weight loss after bariatric surgery.
abstract: OBJECTIVE
  Cortisolemia and 11βHSD1 in liver and adipose tissue are altered in obesity. However, their participation in the development of obesity remains unclear. This study analyzed these parameters in the transition from morbid to type 1 obesity after bariatric surgery.
  
  
  METHODS
  A group of 34 patients with morbid obesity and 22 nonobese subjects were recruited. Initial hypothalamus-pituitary-adrenal (HPA) basal activity and 11βHSD1 mRNA expression in liver, subcutaneous (SAT), and visceral adipose tissue (VAT) were evaluated. A year after bariatric surgery (weight loss of 48 kg), these parameters were reappraised in plasma, SAT, and liver.
  
  
  RESULTS
  Body weight loss was accompanied by a downshift in basal HPA activity and 11βHSD1 expression in SAT. In patients with morbid obesity, 11βHSD1 expression correlated positively with BMI in VAT and negatively in liver at 6 and 12 months after surgery. In SAT, a correlation was observed with body weight only when patients showed type 1 obesity. Insulin, glucose, and HOMA correlated positively with all the HPA indicators and 11βHSD1 expression in SAT.
  
  
  CONCLUSIONS
  Body weight loss after bariatric surgery is accompanied by a downshift in basal HPA activity. Hepatic and VAT 11βHSD1 expressions in morbid obesity are predictors of body weight loss.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Pardina
authors.affiliation: Surgery Unit, Hospital Universitari Arnau De Vilanova, Lleida, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Baena-Fustegueras
authors.affiliation: Endocrinology Surgery Unit, Institut De Recerca Hospital Universitari Vall D'Hebron, Barcelona, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fort
authors.affiliation: Biochemistry Department, Institut De Recerca Hospital Universitari Vall D'Hebron, Barcelona, Spain.
authors.forename: Roser
authors.initials: R
authors.lastname: Ferrer
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.
authors.forename: Joana
authors.initials: J
authors.lastname: Rossell
authors.affiliation: Department of Nutrition and Food Science, University of Barcelona, Barcelona, Spain.|Institute of Biomedicine, University of Barcelona, Barcelona, Spain.|CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Esteve
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.
authors.forename: Julia
authors.initials: J
authors.lastname: Peinado-Onsurbe
authors.affiliation: Department of Nutrition and Food Science, University of Barcelona, Barcelona, Spain.|Institute of Biomedicine, University of Barcelona, Barcelona, Spain.|CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Grasa
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000737:chemistry / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D050110:Bariatric Surgery / Q000379:methods*; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery; D055815:Young Adult
chemical_list: D015415:Biomarkers; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D006854:Hydrocortisone