title: Diagnostic Implementation of Fast and Selective Integrin-Mediated Adhesion of Cancer Cells on Functionalized Zeolite L Monolayers.
abstract: The rapid and exact identification and quantification of specific biomarkers is a key technology for always achieving more efficient diagnostic methodologies. We present the first application of a nanostructured device constituted of patterned self-assembled monolayers of disk-shaped zeolite L coated with the cyclic integrin ligand c[RGDfK] via isocyanate linker, to the rapid detection of cancer cells. With its high specificity toward HeLa and Glioma cells and fast adhesion ability, this biocompatible monolayer is a promising platform for implementation in diagnostics and personalized therapy formulation devices.
authors.affiliation: Department of Chemistry "G. Ciamician", University of Bologna , via Selmi 2, 40126 Bologna, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Greco
authors.affiliation: Institut de science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg , 8 Allée Gaspard Monge, 67000 Strasbourg, France.|Institut für Nanotechnologie (INT), Karlsruhe Institute of Technology (KIT) - Campus Nord, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Maggini
authors.affiliation: Institut de science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg , 8 Allée Gaspard Monge, 67000 Strasbourg, France.|Institut für Nanotechnologie (INT), Karlsruhe Institute of Technology (KIT) - Campus Nord, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
authors.forename: Luisa
authors.initials: L
authors.lastname: De Cola
authors.affiliation: Department of Chemistry "G. Ciamician", University of Bologna , via Selmi 2, 40126 Bologna, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: De Marco
authors.affiliation: Department of Chemistry "G. Ciamician", University of Bologna , via Selmi 2, 40126 Bologna, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Gentilucci
mesh_terms: D002448:Cell Adhesion; D002469:Cell Separation / Q000295:instrumentation*; D006367:HeLa Cells; D006801:Humans; D016023:Integrins / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D036103:Nanotechnology / Q000295:instrumentation*; D010456:Peptides, Cyclic / Q000737:chemistry*; D017641:Zeolites / Q000737:chemistry*
chemical_list: D016023:Integrins; D008024:Ligands; D010456:Peptides, Cyclic; C099250:cyclic (arginyl-glycyl-aspartyl-phenylalanyl-lysyl); D017641:Zeolites