title: One-Pot Catalytic Asymmetric Synthesis of Tetrahydrocarbazoles.
abstract: A one-pot asymmetric synthesis of 1,2,3,4-tetrahydrocarbazoles has been developed via an enantioselective [3 + 3] annulation of 2-alkynylindoles and donor-acceptor cyclopropanes. In the presence of chiral Lewis acids as catalysts, a series of optically active tetrahydrocarbazoles were furnished in high yields (63-87%) with good to excellent levels of enantioselectivity (up to 94% ee).
authors.affiliation: †The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Qiong-Jie
authors.initials: QJ
authors.lastname: Liu
authors.affiliation: †The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Wen-Guang
authors.initials: WG
authors.lastname: Yan
authors.affiliation: †The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Lijia
authors.initials: L
authors.lastname: Wang
authors.affiliation: §Department of Chemistry, University of South Florida, Tampa, Florida 33620-5250, United States.
authors.forename: X Peter
authors.initials: XP
authors.lastname: Zhang
authors.affiliation: †The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003521:Cyclopropanes / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D002227:Carbazoles; D003521:Cyclopropanes; D007211:Indoles