title: Association of branched-chain amino acids with coronary artery disease: A matched-pair case-control study.
abstract: OBJECTIVE
  Several recent studies have found an independent relationship between levels of plasma branched-chain amino acids (BCAAs) and risk factors for coronary artery disease (CAD); however, few studies have investigated the associations of BCAAs with CAD and the risk of cardiovascular events. Therefore, the aim of this study was to investigate the relationship between BCAAs and CAD.
  
  
  RESULTS
  We studied 143 patients with CAD diagnosed by coronary angiography at Beijing Hospital (Beijing, China) during 2008-2011. Apparently healthy control individuals (n = 286) and the patients with CAD were matched (2:1 ratio) by age and gender. The healthy control individuals were selected at random from a set of subjects who attended an annual physical examination at the same hospital in 2011. Conditional logistic regression models were used to evaluate the associations between measured variables and CAD. After multivariate adjustment for traditional CAD risk factors, each one-standard-deviation increase in BCAA concentration was associated with an approximately twofold increase in the risk of CAD (odds ratio = 1.63, 95% confidence interval (CI): 1.21-2.20, P = 0.001). As compared with subjects in the lowest quartile of BCAA levels, the odds ratios (95% CIs) for CAD risk in subjects belonging to quartiles 2, 3, and 4 were 1.65 (0.75-3.61), 2.04 (0.92-4.53), and 3.86 (1.71-8.69), respectively (P trend = 0.01).
  
  
  CONCLUSIONS
  Our results demonstrate that BCAAs are significantly related to CAD development. This relationship is independent of diabetes, hypertension, dyslipidemia, and body mass index.
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: R Y
authors.initials: RY
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: S M
authors.initials: SM
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Beijing Hospital, Ministry of Health, Beijing, China.
authors.forename: J M
authors.initials: JM
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: H X
authors.initials: HX
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital, Jiamusi University, Heilongjiang, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Sui
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China; Beijing Hospital, National Center for Clinical Laboratories, Ministry of Health, Beijing, China.
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: H L
authors.initials: HL
authors.lastname: Xiu
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Hospital, Ministry of Health, Beijing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: He
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China. Electronic address: jun_dong@263.net.
authors.forename: J
authors.initials: J
authors.lastname: Dong
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China; Beijing Hospital, National Center for Clinical Laboratories, Ministry of Health, Beijing, China.
authors.forename: W X
authors.initials: WX
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000597:Amino Acids, Branched-Chain / Q000097:blood*; D000068476:Beijing; D016022:Case-Control Studies; D002681:China; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D000597:Amino Acids, Branched-Chain
keywords: Branched-chain amino acids; Case–control study; Coronary artery disease; Odds ratio; Risk factor