title: Maximizing biomass concentration in baker's yeast process by using a decoupled geometric controller for substrate and dissolved oxygen.
abstract: Biomass production by baker's yeast in a fed-batch reactor depends on the metabolic regime determined by the concentration of glucose and dissolved oxygen in the reactor. Achieving high biomass concentration in turn is dependent on the dynamic interaction between the glucose and dissolved oxygen concentration. Taking this into account, we present in this paper the implementation of a decoupled input-output linearizing controller (DIOLC) for maximizing biomass in a fed-batch yeast process. The decoupling is based on the inversion of 2×2 input-output matrix resulting from global linearization. The DIOLC was implemented online using a platform created in LabVIEW employing a TCP/IP protocol via the reactor's built-in electronic system. An improvement in biomass yield by 23% was obtained compared to that using a PID controller. The results demonstrate superior capability of the DIOLC and that the cumulative effect of smoother control action contributes to biomass maximization.
authors.affiliation: Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India.
authors.forename: Viki R
authors.initials: VR
authors.lastname: Chopda
authors.affiliation: Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India.
authors.forename: Anurag S
authors.initials: AS
authors.lastname: Rathore
authors.affiliation: Kusuma School of Biological Sciences, IIT Delhi, Hauz Khas, New Delhi, India. Electronic address: jgomes@bioschool.iitd.ac.in.
authors.forename: James
authors.initials: J
authors.lastname: Gomes
mesh_terms: D000465:Algorithms; D056804:Biofuels; D018533:Biomass; D019149:Bioreactors; D005285:Fermentation; D005947:Glucose; D010100:Oxygen; D012441:Saccharomyces cerevisiae / Q000254:growth & development*
chemical_list: D056804:Biofuels; D005947:Glucose; D010100:Oxygen
keywords: Baker’s yeast; Biomass; Decoupling; Fermentation; Non-linear control