title: Bordetella pertussis, B. parapertussis, vaccines and cycles of whooping cough.
abstract: Whooping cough is a vaccine-preventable disease due to Bordetella pertussis and B. parapertussis. This highly contagious respiratory disease occurs through epidemic cycles every 3-5 years and vaccination did not change this frequency. Models suggest that the cyclic increase of susceptibles is linked to demographic differences and different vaccine coverage. However, differences in surveillance of the disease as well as adaptation of the agents of the disease to their human hosts and to vaccine pressure might also play an important role. These parameters are discussed in this review.
authors.affiliation: Institut Pasteur, Molecular Prevention and Therapy of Human Infections Unit, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France CNRS URA-3012, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France valerie.bouchez@pasteur.fr.
authors.forename: Valérie
authors.initials: V
authors.lastname: Bouchez
authors.affiliation: Institut Pasteur, Molecular Prevention and Therapy of Human Infections Unit, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France CNRS URA-3012, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
mesh_terms: D042483:Bordetella parapertussis / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology*; D006801:Humans; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D010567:Pertussis Vaccine
keywords: Bordetella parapertussis; Bordetella pertussis; polymorphism; vaccine; whooping cough