title: Dynamic contrast enhanced ultrasound for therapy monitoring.
abstract: Quantitative imaging is a crucial component of the assessment of therapies that target the vasculature of angiogenic or inflamed tissue. Dynamic contrast-enhanced ultrasound (DCE-US) using microbubble contrast offers the advantages of being sensitive to perfusion, non-invasive, cost effective and well suited to repeated use at the bedside. Uniquely, it employs an agent that is truly intravascular. This papers reviews the principles and methodology of DCE-US, especially as applied to anti-angiogenic cancer therapies. Reproducibility is an important attribute of such a monitoring method: results are discussed. More recent technical advances in parametric and 3D DCE-US imaging are also summarised and illustrated.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
authors.forename: John M
authors.initials: JM
authors.lastname: Hudson
authors.affiliation: Imaging Research, Sunnybrook Research Institute, Toronto, ON, Canada.
authors.forename: Ross
authors.initials: R
authors.lastname: Williams
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
authors.forename: Charles
authors.initials: C
authors.lastname: Tremblay-Darveau
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Sheeran
authors.affiliation: Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
authors.forename: Laurent
authors.initials: L
authors.lastname: Milot
authors.affiliation: Department of Medical Oncology, University of Toronto, and Sunnybrook Odette Cancer Centre, Toronto, ON, Canada.
authors.forename: Georg A
authors.initials: GA
authors.lastname: Bjarnason
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Imaging Research, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada. Electronic address: burns@sri.utoronto.ca.
authors.forename: Peter N
authors.initials: PN
authors.lastname: Burns
mesh_terms: D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement; D021621:Imaging, Three-Dimensional; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000628:therapy; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging* / Q000628:therapy; D045423:Microbubbles; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D015203:Reproducibility of Results; D018615:Ultrasonography, Doppler, Color
chemical_list: D003287:Contrast Media
keywords: Anti-angiogenic therapy; Anti-inflammatory therapy; Cancer; Contrast enhanced ultrasound; Inflammatory bowel disease; Therapy assessment