title: Aminocaproic Acid and Tranexamic Acid Fail to Reverse Dabigatran-Induced Coagulopathy.
abstract: In recent years, dabigatran has emerged as a popular alternative to warfarin for treatment of atrial fibrillation. If rapid reversal is required, however, no reversal agent has clearly been established. The primary purpose of this manuscript was to evaluate the efficacy of tranexamic acid and aminocaproic acid as agents to reverse dabigatran-induced coagulopathy. Rats were randomly assigned to 6 groups. Each rat received either dabigatran or oral placebo, followed by saline, tranexamic acid, or aminocaproic acid. An activated clotting test was used to measure the coagulopathy. Neither tranexamic acid nor aminocaproic acid successfully reversed dabigatran-induced coagulopathy. In this rodent model of dabigatran-induced coagulopathy, neither tranexamic acid nor aminocaproic acid were able to reverse the coagulopathy.
authors.affiliation: 1Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA; 2Department of Emergency Medicine, University of Southern California, Los Angeles, CA; 3University of Southern California, Los Angeles, CA; and 4Department of Emergency Medicine, University of Oklahoma School of Community Medicine, Tulsa, OK.
authors.forename: Michael
authors.initials: M
authors.lastname: Levine
authors.forename: Margaret
authors.initials: M
authors.lastname: Huang
authors.forename: Sean O
authors.initials: SO
authors.lastname: Henderson
authors.forename: Guy
authors.initials: G
authors.lastname: Carmelli
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Thomas
mesh_terms: D015119:Aminocaproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000209:etiology*; D000069604:Dabigatran / Q000009:adverse effects*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014148:Tranexamic Acid; D000069604:Dabigatran; D015119:Aminocaproic Acid