title: Synthesis and biological evaluation of 9-N-oxamyl sialosides as Siglec-7 ligands.
abstract: Siglecs (sialic acid recognizing immunoglobulin like lectins) are a family of lectins with specificity for sialic acid containing carbohydrates. Synthetic sialic acid derivatives with high affinity proved useful to unravel the biological role of the ligand binding domain, although many of their functions in immunity remain unknown. Here we present design, synthesis, affinity evaluation and molecular modeling of novel 9-N-oxamoyl modified sialosides as Siglec-7 ligands.
authors.affiliation: G3-BioTec, 69207 Sandhausen, Germany.
authors.forename: Horst
authors.initials: H
authors.lastname: Prescher
authors.affiliation: Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Gütgemann
authors.affiliation: Molecular Structure Analysis Core Facility-W160, German Cancer Research Center, 69120 Heidelberg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Frank
authors.affiliation: G3-BioTec, 69207 Sandhausen, Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Kuhfeldt
authors.affiliation: Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Watzl
authors.affiliation: G3-BioTec, 69207 Sandhausen, Germany; Biochemistry Center, University of Heidelberg, 69120 Heidelberg, Germany. Electronic address: reinhard.brossmer@bzh.uni-heidelberg.de.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Brossmer
mesh_terms: D037102:Lectins / Q000378:metabolism; D008024:Ligands; D015394:Molecular Structure; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D009438:Neuraminic Acids / Q000737:chemistry*
chemical_list: D037102:Lectins; D008024:Ligands; D009438:Neuraminic Acids; D019158:N-Acetylneuraminic Acid
keywords: Lectin; Neuraminic acid; Sialic acid; Sialoside; Siglec