title: Comparison of treatment with continuous subcutaneous insulin infusion versus multiple daily insulin injections with bolus calculator in patients with type 1 diabetes.
abstract: OBJECTIVE
  A study of the glycemic control, quality of life, and fear and perception of hypoglycemia by comparing continuous subcutaneous insulin infusion (CSII) group with multiple daily inyections (MDI) with bolus calculator group.
  
  
  METHODS
  This is a retrospective cohort study with following up during the first 12 months that CSII group (n=30) begins the use of "bolus wizard" and the MDI-calculator (n=30) group begins the use of the bolus calculator (Accu-Chek(®) Aviva Expert).
  
  
  METHODS
  HbA1c (3, 6 and 12 months). Questionnaires used: EsDQOL (quality of life), FH-15 (fear of hypoglycemia), and Clarke (perception of hypoglycemia).
  
  
  METHODS
  T Student and nonparametric tests.
  
  
  RESULTS
  The average reduction in HbA1c during the study was significantly higher in CSII group (-0.56±0.84%) compared with the MDI group (0.097±0.94%), P=.028. The average basal insulin dose was significantly higher in the MDI group (at baseline, 6 and 12 months). No significant differences were found between the 2 treatment groups after analyzing the EsDQOL, FH-15 and Clarke questionnaires. In the CSII group, perceived quality of life assessed by the EsDQOL questionnaire was found to be better at the end of the study than at the beginning of using the insulin pump.
  
  
  CONCLUSIONS
  The average reduction in HbA1c was significantly higher in the CSII group. In the CSII group, perceived quality of life was better at the end of the study than at the beginning.
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España. Electronic address: leyre.perezgarcia2@osakidetza.net.
authors.forename: L
authors.initials: L
authors.lastname: Pérez-García
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Goñi-Iriarte
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.
authors.forename: M
authors.initials: M
authors.lastname: García-Mouriz
mesh_terms: D000328:Adult; D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005239:Fear; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000517:prevention & control / Q000523:psychology; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D008297:Male; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Bolus calculator; Calculador de bolus; Calidad de vida; Continuous subcutaneous insulin infusion; Hipoglucemia; Hypoglycemia; Infusión subcutánea continua insulina; Multiple daily injections; Múltiples dosis de Insulina; Quality of life