title: Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions.
abstract: Three solvent based methods: spray drying (SD), electrospinning (ES) and air-assisted electrospinning (electroblowing; EB) were used to prepare solid dispersions of itraconazole and Eudragit E. Samples with the same API/polymer ratios were prepared in order to make the three technologies comparable. The structure and morphology of solid dispersions were identified by scanning electron microscopy and solid phase analytical methods such as, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Raman chemical mapping. Moreover, the residual organic solvents of the solid products were determined by static headspace-gas chromatography/mass spectroscopy measurements and the wettability of samples was characterized by contact angle measurement. The pharmaceutical performance of the three dispersion type, evaluated by dissolution tests, proved to be very similar. According to XRPD and DSC analyses, made after the production, all the solid dispersions were free of any API crystal clusters but about 10 wt% drug crystallinity was observed after three months of storage in the case of the SD samples in contrast to the samples produced by ES and EB in which the polymer matrix preserved the API in amorphous state.
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary.
authors.forename: Péter Lajos
authors.initials: PL
authors.lastname: Sóti
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Bocz
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary.
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Pataki
authors.affiliation: Joint Research and Training Laboratory on Separation Techniques, Eötvös Loránd University, H-1117 Budapest, Pázmány Péter sétány 1/A, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Eke
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Farkas
authors.affiliation: Janssen Research & Development, Beerse, Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Verreck
authors.affiliation: Institute of Chemistry, Eötvös Loránd University, H-1117 Budapest, Pázmány Péter sétány 1/A, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Kiss
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary; Meditop Pharmaceutical Ltd., H-2097 Pilisborosjenő, Ady Endre utca 1, Hungary.
authors.forename: Pál
authors.initials: P
authors.lastname: Fekete
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Vigh
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Wagner
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary.
authors.forename: Zsombor K
authors.initials: ZK
authors.lastname: Nagy
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3-9, Hungary. Electronic address: gmarosi@mail.bme.hu.
authors.forename: György
authors.initials: G
authors.lastname: Marosi
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003890:Desiccation / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry; D017964:Itraconazole / Q000737:chemistry*; D008768:Methylmethacrylates / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D011208:Powders / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D017155:Wettability; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D004337:Drug Carriers; D008768:Methylmethacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; D011208:Powders; D012997:Solvents; C102808:Eudragit-E; C038300:methylmethacrylate-methacrylic acid copolymer; D017964:Itraconazole
keywords: Electroblowing; Electrospinning; Itraconazole; Raman mapping; Rapid dissolution; Spray drying