title: Interleukin-6 in CLL: accelerator or brake?
abstract: In this issue of Blood, Li et al provide insight into the interactions between immunoreceptor signals in a human cancer microenvironment presenting a novel mechanism by which microenvironment-produced interleukin (IL)-6 acts as a tumor suppressor in chronic lymphocytic leukemia (CLL) by inhibiting toll-like receptor (TLR) signaling.
authors.affiliation: THE OHIO STATE UNIVERSITY.
authors.forename: Rosa
authors.initials: R
authors.lastname: Lapalombella
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology*; D035683:MicroRNAs / Q000276:immunology*; D017154:Stromal Cells / Q000276:immunology*
chemical_list: D015850:Interleukin-6; D035683:MicroRNAs