title: The Use of Stem Cells in Burn Wound Healing: A Review.
abstract: Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem cells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated.
authors.affiliation: Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Fadi
authors.initials: F
authors.lastname: Ghieh
authors.affiliation: Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC, USA.
authors.forename: Rosalyn
authors.initials: R
authors.lastname: Jurjus
authors.affiliation: Department of Surgery, American University of Beirut, Beirut, Lebanon.
authors.forename: Amir
authors.initials: A
authors.lastname: Ibrahim
authors.affiliation: Lebanese Health Society, Beirut, Lebanon.
authors.forename: Alice Gerges
authors.initials: AG
authors.lastname: Geagea
authors.affiliation: Department of Anatomy, Cell Biology, and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Hisham
authors.initials: H
authors.lastname: Daouk
authors.affiliation: Department of Anatomy, Cell Biology, and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Bassel
authors.initials: B
authors.lastname: El Baba
authors.affiliation: Department of Anatomy, Cell Biology, and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Sana
authors.initials: S
authors.lastname: Chams
authors.affiliation: Lebanese Health Society, Beirut, Lebanon.
authors.forename: Michel
authors.initials: M
authors.lastname: Matar
authors.affiliation: Eye Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Wadih
authors.initials: W
authors.lastname: Zein
authors.affiliation: Department of Anatomy, Cell Biology, and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Abdo
authors.initials: A
authors.lastname: Jurjus
mesh_terms: D002056:Burns / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D003315:Cornea / Q000473:pathology; D006801:Humans; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D014945:Wound Healing