title: Clozapine-induced acute interstitial nephritis.
abstract: Acute interstitial nephritis is a common cause of acute kidney injury. Acute interstitial nephritis is most commonly induced by drug although the cause may also be infective, autoimmune, or idiopathic. Although eosinophilia and eosinophiluria may help identify this disease entity, the gold standard for diagnosis remains renal biopsy. Prompt diagnosis is important because discontinuation of the culprit drugs can reduce further kidney injury. We present a patient with an underlying psychiatric disorder who was subsequently diagnosed with clozapine-induced acute interstitial nephritis. Monitoring of renal function during clozapine therapy is recommended for early recognition of this rare side-effect.
authors.affiliation: Department of Medicine, Queen Elizabeth Hospital, Jordan, Hong Kong.
authors.forename: S Y
authors.initials: SY
authors.lastname: Chan
authors.affiliation: Department of Medicine, Queen Elizabeth Hospital, Jordan, Hong Kong.
authors.forename: C Y
authors.initials: CY
authors.lastname: Cheung
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Jordan, Hong Kong.
authors.forename: P T
authors.initials: PT
authors.lastname: Chan
authors.affiliation: Department of Medicine, Queen Elizabeth Hospital, Jordan, Hong Kong.
authors.forename: K F
authors.initials: KF
authors.lastname: Chau
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D003024:Clozapine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine
keywords: Acute disease; Clozapine/adverse effects; Nephritis, interstitial