title: Getting the genome in shape: the formation of loops, domains and compartments.
abstract: The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.
authors.affiliation: Hubrecht Institute - KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
authors.forename: Britta A M
authors.initials: BA
authors.lastname: Bouwman
authors.affiliation: Hubrecht Institute - KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands. w.delaat@hubrecht.eu.
authors.forename: Wouter
authors.initials: W
authors.lastname: de Laat
mesh_terms: D002843:Chromatin / Q000737:chemistry*; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D016678:Genome; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D014157:Transcription Factors