title: Radiofrequency Ablation of Functioning Adrenal Adenomas: Preliminary Clinical and Laboratory Findings.
abstract: OBJECTIVE
  To evaluate clinical and laboratory findings in patients undergoing radiofrequency (RF) ablation for functioning adrenal adenomas.
  
  
  METHODS
  Eleven adult patients, nine with Conn syndrome and two with Cushing syndrome, underwent percutaneous computed tomography-guided RF ablation for benign adrenal neoplasms. Systolic, diastolic, and mean blood pressure and the number of classes of antihypertensive drugs used by each patient were analyzed before and 1, 4, and 12 weeks after the procedure. Serum hormone levels were analyzed within 30 days before and 12 weeks after the procedure.
  
  
  RESULTS
  Of the nine patients with Conn syndrome, eight showed normal serum aldosterone levels after the procedure and one patient had a nodule located very close to the inferior vena cava, resulting in incomplete ablation. The two patients with Cushing syndrome had normal serum and salivary cortisol levels after the procedure. Mean aldosterone concentration at baseline was 63.3 ng/dL ± 28.0 and decreased to 13.3 ng/dL ± 13.5 at 12 weeks postoperatively (P = .008). Systolic, diastolic, and mean blood pressures decreased significantly in the first week after the procedure (P < .001) and remained stable during further follow-up.
  
  
  CONCLUSIONS
  In patients with Conn syndrome or Cushing syndrome, percutaneous RF ablation of functioning adrenal adenomas may result in normalization of hormone secretion, improvement in blood pressure, and reduced need for antihypertensive drugs.
authors.affiliation: Department of Diagnostic Imaging, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Napoleão de Barros, 800, São Paulo, SP 04024-002, Brazil.. Electronic address: denis.cura@gmail.com.
authors.forename: Denis
authors.initials: D
authors.lastname: Szejnfeld
authors.affiliation: Department of Diagnostic Imaging, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Napoleão de Barros, 800, São Paulo, SP 04024-002, Brazil.
authors.forename: Thiago Franchi
authors.initials: TF
authors.lastname: Nunes
authors.affiliation: Department of Clinical Medicine, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Napoleão de Barros, 800, São Paulo, SP 04024-002, Brazil.
authors.forename: Endrigo Emanuel
authors.initials: EE
authors.lastname: Giordano
authors.affiliation: Department of Clinical Medicine, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Napoleão de Barros, 800, São Paulo, SP 04024-002, Brazil.
authors.forename: Fabio
authors.initials: F
authors.lastname: Freire
authors.affiliation: Department of Diagnostic Imaging, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Napoleão de Barros, 800, São Paulo, SP 04024-002, Brazil.
authors.forename: Sergio Aron
authors.initials: SA
authors.lastname: Ajzen
authors.affiliation: Division of Endocrinology and Department of Medicine (C.E.K.), Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Napoleão de Barros, 800, São Paulo, SP 04024-002, Brazil.
authors.forename: Claudio Elias
authors.initials: CE
authors.lastname: Kater
authors.affiliation: Department of Diagnostic Imaging, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Napoleão de Barros, 800, São Paulo, SP 04024-002, Brazil.
authors.forename: Suzan Menasce
authors.initials: SM
authors.lastname: Goldman
mesh_terms: D000236:Adenoma / Q000097:blood / Q000175:diagnosis* / Q000601:surgery*; D000310:Adrenal Gland Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000601:surgery*; D000328:Adult; D000450:Aldosterone / Q000097:blood; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D025321:Surgery, Computer-Assisted / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D000450:Aldosterone