title: Mucoadhesive-floating zinc-pectinate-sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl.
abstract: A novel dual crosslinked low-methoxyl (LM) pectinate-sterculia gum (SG) interpenetrating polymer network (IPN) beads was developed for intragastric ziprasidone delivery. The IPN beads were accomplished by simultaneous ionotropic gelation with zinc acetate and covalent crosslinking with glutaraldehyde. The effects of pectin and SG contents on drug entrapment efficiency (DEE, %), and cumulative drug release after 8h (Q8, %) were studied to optimize the IPN beads using a 3(2) factorial design. The optimized beads encapsulating ziprasidone HCl (F-O) displayed DEE of 87.98±1.15% and Q8 of 58.81±1.50% with excellent buoyancy (floating lag time <2min, % buoyancy at 8h >63%) and good mucoadhesivity with the goat gastric mucosa. In most cases, the drug release behaviour obeyed Higuchi kinetics with anomalous transport mechanism. The Zn-pectinate-SG IPN beads were also characterized by SEM, FTIR, DSC and P-XRD analyses.
authors.affiliation: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, Andhra Pradesh, India. Electronic address: hriday.bera1@gmail.com.
authors.forename: Hriday
authors.initials: H
authors.lastname: Bera
authors.affiliation: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, Andhra Pradesh, India.
authors.forename: Shashank
authors.initials: S
authors.lastname: Boddupalli
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India. Electronic address: amitkrnayak@yahoo.co.in.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
mesh_terms: D000269:Adhesives / Q000737:chemistry*; D000818:Animals; D002152:Calorimetry, Differential Scanning; D065546:Drug Liberation; D006041:Goats; D008863:Microspheres; D009077:Mucins / Q000737:chemistry*; D010316:Particle Size; D010368:Pectins / Q000737:chemistry*; D010879:Piperazines / Q000494:pharmacology*; D053149:Plant Gums / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D032361:Sterculia / Q000737:chemistry*; D013499:Surface Properties; D013844:Thiazoles / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000269:Adhesives; D009077:Mucins; D010879:Piperazines; D053149:Plant Gums; D011108:Polymers; D013844:Thiazoles; C092292:ziprasidone; D010368:Pectins
keywords: Glutaraldehyde; Interpenetrating polymer network; Pectin; Sterculia gum; Sustained release; Ziprasidone HCl