title: Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments.
abstract: The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.
authors.affiliation: Department of Clinic-Surgical Sciences, Experimental Surgery Laboratory, University of Pavia, Italy; IRCCS S. Matteo Hospital, Pavia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cansolino
authors.affiliation: Department of Clinic-Surgical Sciences, Experimental Surgery Laboratory, University of Pavia, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Clerici
authors.affiliation: Department of Clinic-Surgical Sciences, Experimental Surgery Laboratory, University of Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Zonta
authors.affiliation: Department of Clinic-Surgical Sciences, Experimental Surgery Laboratory, University of Pavia, Italy; IRCCS S. Matteo Hospital, Pavia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Dionigi
authors.affiliation: IGM-CNR and Department of Biology and Biotechnologies "L. Spallanzani", University of Pavia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mazzini
authors.affiliation: IRCCS S. Matteo Hospital, Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Di Liberto
authors.affiliation: Department of Physics, University of Pavia, Italy; INFN (National Institute of Nuclear Physics) Section of Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Altieri
authors.affiliation: Department of Physics, University of Pavia, Italy; INFN (National Institute of Nuclear Physics) Section of Pavia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ballarini
authors.affiliation: INFN (National Institute of Nuclear Physics) Section of Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bortolussi
authors.affiliation: Department of Physics, University of Pavia, Italy; INFN (National Institute of Nuclear Physics) Section of Pavia, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: Carante
authors.affiliation: Department of Physics, University of Pavia, Italy; INFN (National Institute of Nuclear Physics) Section of Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
authors.affiliation: Comisión Nacional de Energía Atómica (CNEA), Buenos Aires, Argentina; CONICET, Argentina.
authors.forename: S J
authors.initials: SJ
authors.lastname: González
authors.affiliation: Department of Physics, University of Pavia, Italy; INFN (National Institute of Nuclear Physics) Section of Pavia, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Postuma
authors.affiliation: Department of Physics, University of Pavia, Italy; INFN (National Institute of Nuclear Physics) Section of Pavia, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Protti
authors.affiliation: Comisión Nacional de Energía Atómica (CNEA), Buenos Aires, Argentina.
authors.forename: G A
authors.initials: GA
authors.lastname: Santa Cruz
authors.affiliation: Department of Clinic-Surgical Sciences, Experimental Surgery Laboratory, University of Pavia, Italy. Electronic address: cinzia.ferrari@unipv.it.
authors.forename: C
authors.initials: C
authors.lastname: Ferrari
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy; D002448:Cell Adhesion / Q000528:radiation effects*; D002453:Cell Cycle / Q000528:radiation effects; D045744:Cell Line, Tumor; D005720:Gamma Rays; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009502:Neutrons; D051381:Rats
keywords: BNCT; Cell cycle; Cell survival; Radiobiological effects