title: Emerging advances in cancer nanotheranostics with graphene nanocomposites: opportunities and challenges.
abstract: As an inorganic nanomaterial, graphene nanocomposites have gained much attention in cancer nanotechnology compared with the other inorganic nanomaterial in recent times. Although a relatively new drug carrier, it has been extensively explored as a potential chemotherapeutic carrier and theranostic because of its numerous physicochemical properties, including, capability of multiple pay load, functionalization for drug targeting and photothermal effect. Despite potential benefit, its translation from bench to bed-side in cancer therapy is challenged due to its toxicity concern. Here, we discussed the present progress and future possibilities of graphene nanocomposites as a cancer theranostic. Moreover, the paper also exemplifies the effects of graphene/graphene oxide on tissues and organ functions in order to understand the extent and mechanism of toxicity.
authors.affiliation: Nanomedicine Research Lab, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
authors.forename: Mahfoozur
authors.initials: M
authors.lastname: Rahman
authors.affiliation: LE STUDIUM® Loire Valley Institute for Advanced Studies, Centre-Val de Loire region, France.|Centre de Biophysique Moléculaire, CNRS UPR4301, Orléans, France.
authors.forename: Sohail
authors.initials: S
authors.lastname: Akhter
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Najran University, Saudi Arabia.
authors.forename: Mohammad Zaki
authors.initials: MZ
authors.lastname: Ahmad
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
authors.forename: Javed
authors.initials: J
authors.lastname: Ahmad
authors.affiliation: Union University, School of Pharmacy Room 149 Providence Hall, 1050 Union University Drive, Jackson, TN 38305, USA.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Addo
authors.affiliation: Nanomedicine Research Lab, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.|Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
authors.forename: Farhan Jalees
authors.initials: FJ
authors.lastname: Ahmad
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR4301, Orléans, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Pichon
mesh_terms: D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053761:Nanocomposites; D050997:Nanomedicine; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy*; D000068936:Theranostic Nanomedicine
chemical_list: D006108:Graphite
keywords: anticancer; biodistribution; cellular interaction; graphene; graphene oxide; in vitro in vivo toxicity; inorganic nanoparticle; nanotoxicity; theranostics