title: Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects.
abstract: ABO blood groups are known to influence the plasma level of von Willebrand factor (VWF), but little is known about the relationship between ABO and coagulation factor VIII (FVIII). We analyzed the influence of ABO genotypes on VWF antigen, FVIII activity, and their quantitative relationship in 11,673 participants in the Atherosclerosis Risk in Communities (ARIC) study. VWF, FVIII, and FVIII/VWF levels varied significantly among O, A (A1 and A2), B and AB subjects, and the extent of which varied between Americans of European (EA) and African (AA) descent. We validated a strong influence of ABO blood type on VWF levels (15.2%), but also detected a direct ABO influence on FVIII activity (0.6%) and FVIII/VWF ratio (3.8%) after adjustment for VWF. We determined that FVIII activity changed 0.54% for every 1% change in VWF antigen level. This VWF-FVIII relationship differed between subjects with O and B blood types in EA, AA, and in male, but not female subjects. Variations in FVIII activity were primarily detected at low VWF levels. These new quantitative influences on VWF, FVIII and the FVIII/VWF ratio help understand how ABO genotypes differentially influence VWF, FVIII and their ratio, particularly in racial and gender specific manners.
authors.affiliation: Puget Sound Blood Center Research Institute, Puget Sound Blood Center, Seattle, Washington, United States of America; Department of Laboratory Medicine, Yonsei University, College of Medicine, Seoul, Korea.
authors.forename: Jaewoo
authors.initials: J
authors.lastname: Song
authors.affiliation: Human Genetic Center, University of Texas School of Public Health, Houston, Texas, United States of America.
authors.forename: Fengju
authors.initials: F
authors.lastname: Chen
authors.affiliation: Cardiology Section, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Marco
authors.initials: M
authors.lastname: Campos
authors.affiliation: Puget Sound Blood Center Research Institute, Puget Sound Blood Center, Seattle, Washington, United States of America.
authors.forename: Doug
authors.initials: D
authors.lastname: Bolgiano
authors.affiliation: Puget Sound Blood Center Research Institute, Puget Sound Blood Center, Seattle, Washington, United States of America.
authors.forename: Katie
authors.initials: K
authors.lastname: Houck
authors.affiliation: Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Lloyd E
authors.initials: LE
authors.lastname: Chambless
authors.affiliation: National Health Research Institutes, Taipei, Taiwan.
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Wu
authors.affiliation: Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Folsom
authors.affiliation: Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: David
authors.initials: D
authors.lastname: Couper
authors.affiliation: Human Genetic Center, University of Texas School of Public Health, Houston, Texas, United States of America.
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.affiliation: Puget Sound Blood Center Research Institute, Puget Sound Blood Center, Seattle, Washington, United States of America; Division of Hematology, Department of Medicine, University of Washington, School of Medicine, Seattle, Washington, United States of America.
authors.forename: Jing-fei
authors.initials: JF
authors.lastname: Dong
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood / Q000235:genetics*; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics*; D044383:Black People / Q000235:genetics; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D044465:White People / Q000235:genetics; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D000017:ABO Blood-Group System; D014841:von Willebrand Factor; D005169:Factor VIII