title: DRESS Syndrome Following Levofloxacin Exposure With Positive Patch-test.
abstract: Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) in a severe cutaneous drug reaction, which can be life threatening. Levofloxacin has not been reported in literature as a causative drug. We are presenting an exceptional case of levofloxacin-induced DRESS without eosinophilia and with positive patch-tests to levofloxacin.
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia.
authors.forename: Ons
authors.initials: O
authors.lastname: Charfi
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia - Tunis El Manar University, Medicine Faculty, Tunis, Tunisia.
authors.forename: Ghozlane
authors.initials: G
authors.lastname: Lakhoua
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia - Tunis El Manar University, Medicine Faculty, Tunis, Tunisia.
authors.forename: Rim
authors.initials: R
authors.lastname: Sahnoun
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia - Department of Dermatology, Habib Thameur Hospital, Tunis, Tunisia.
authors.forename: Talel
authors.initials: T
authors.lastname: Badri
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia - Tunis El Manar University, Medicine Faculty, Tunis, Tunisia.
authors.forename: Riadh
authors.initials: R
authors.lastname: Daghfous
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia - Tunis El Manar University, Medicine Faculty, Tunis, Tunisia.
authors.forename: Sihem
authors.initials: S
authors.lastname: El Aidli
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia - Tunis El Manar University, Medicine Faculty, Tunis, Tunisia.
authors.forename: Sarah
authors.initials: S
authors.lastname: Kastalli
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia - Tunis El Manar University, Medicine Faculty, Tunis, Tunisia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Zaïem
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis / Q000209:etiology*; D004359:Drug Therapy, Combination; D020031:Epstein-Barr Virus Infections / Q000188:drug therapy; D024841:Fluoroquinolones / Q000009:adverse effects; D006801:Humans; D064704:Levofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D008111:Liver Function Tests; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D010328:Patch Tests; D010636:Phenols / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D010636:Phenols; D008795:Metronidazole; D000082:Acetaminophen; D064704:Levofloxacin; C533149:2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)