title: In vivo endoscopic tissue identification by rapid evaporative ionization mass spectrometry (REIMS).
abstract: Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer-related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.
authors.affiliation: Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ (UK).
authors.forename: Julia
authors.initials: J
authors.lastname: Balog
authors.affiliation: Department of Surgery and Cancer, Imperial College London, St. Mary's Hospital, QEQM 10th floor, London W2 1NY (UK).
authors.forename: Sacheen
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Surgery and Cancer, Imperial College London, St. Mary's Hospital, QEQM 10th floor, London W2 1NY (UK).
authors.forename: James
authors.initials: J
authors.lastname: Alexander
authors.affiliation: Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ (UK).
authors.forename: Ottmar
authors.initials: O
authors.lastname: Golf
authors.affiliation: Department of Surgery and Cancer, Imperial College London, St. Mary's Hospital, QEQM 10th floor, London W2 1NY (UK).
authors.forename: Juzheng
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Surgery and Cancer, Imperial College London, St. Mary's Hospital, QEQM 10th floor, London W2 1NY (UK).
authors.forename: Tom
authors.initials: T
authors.lastname: Wiggins
authors.affiliation: Department of Surgery and Cancer, Imperial College London, St. Mary's Hospital, QEQM 10th floor, London W2 1NY (UK).
authors.forename: Nima
authors.initials: N
authors.lastname: Abbassi-Ghadi
authors.affiliation: Institute of Surgery, University of Debrecen, Moricz Zsigmond krt. 22, Debrecen 4032 (Hungary).
authors.forename: Attila
authors.initials: A
authors.lastname: Enyedi
authors.affiliation: Gastroenterology Clinic, University of Debrecen, Nagyerdei krt. 98., Debrecen 4032 (Hungary).
authors.forename: Sandor
authors.initials: S
authors.lastname: Kacska
authors.affiliation: Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ (UK).
authors.forename: James
authors.initials: J
authors.lastname: Kinross
authors.affiliation: Department of Surgery and Cancer, Imperial College London, St. Mary's Hospital, QEQM 10th floor, London W2 1NY (UK).
authors.forename: George B
authors.initials: GB
authors.lastname: Hanna
authors.affiliation: Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ (UK).
authors.forename: Jeremy K
authors.initials: JK
authors.lastname: Nicholson
authors.affiliation: Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ (UK). z.takats@imperial.ac.uk.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Takats
mesh_terms: D016099:Endoscopy, Gastrointestinal; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*
keywords: cancer; endoscopy; in vivo characterization; mass spectrometry; phospholipids