title: Perioperative chemotherapy more of a benefit for overall survival than adjuvant chemotherapy for operable gastric cancer: an updated Meta-analysis.
abstract: To clarify the effect of neoadjuvant chemotherapy (NAC) on the survival outcomes of operable gastric cancers, we searched PubMed, Embase, and Cochrane Library for randomized clinical trials published until June 2014 that compared NAC-containing strategies with NAC-free strategies in patients with adenocarcinoma of the stomach or the esophagogastric junction, who had undergone potentially curative resection. The adjusted pooled hazard ratio (HR) for overall survival (OS) was insignificant when comparing the NAC-containing arm with the NAC-free arm. Subgroup analysis showed that the OS of the treatment arm that involved both adjuvant chemotherapy (AC) and NAC was significantly improved over the control arm (AC only) (HR = 0.48, 95% CI: 0.35-0.67; P < 0.001). While NAC alone plus surgery did not show any survival benefit over surgery alone. Perioperative chemotherapy (PC) also showed a significant increase in PFS and a significant reduction in distant metastasis compared to surgery alone. Therefore, in patients with resectable gastric cancer, NAC alone is not enough and AC alone is not good enough to definitely improve their OS. Collectively, PC combined with surgery could maximize the survival benefit for patients with resectable gastric cancer.
authors.affiliation: Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Ya'nan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yin
authors.affiliation: Cancer Therapeutics Laboratory, Centre for Personalized Cancer Medicine, School of Medicine, University of Adelaide, Australia.
authors.forename: Lei
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Cancer, Weifang Traditional Chinese Medical Hospital, Weifang, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Dong
authors.affiliation: Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000517:prevention & control*; D059035:Perioperative Period; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*