title: Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1.
abstract: Steroidogenic factor-1 (SF-1) and liver receptor homolog-1 (LRH-1) belong to the nuclear receptor superfamily and are categorized as orphan receptors. In addition to other nuclear receptors, these play roles in various physiological phenomena by regulating the transcription of target genes. Both factors share very similar structures and exhibit common functions. Of these, the roles of SF-1 and LRH-1 in steroidogenesis are the most important, especially that of SF-1, which was originally discovered and named to reflect such roles. SF-1 and LRH-1 are essential for steroid hormone production in gonads and adrenal glands through the regulation of various steroidogenesis-related genes. As SF-1 is also necessary for the development of gonads and adrenal glands, it is also considered a master regulator of steroidogenesis. Recent studies have clearly demonstrated that LRH-1 also represents another master regulator of steroidogenesis, which similarly to SF-1, can induce differentiation of non-steroidogenic stem cells into steroidogenic cells. Here, we review the functions of both factors in these steroidogenesis-related phenomena.
authors.affiliation: 1 Department of Biochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yazawa
authors.affiliation: 2 Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Imamichi
authors.affiliation: 2 Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Miyamoto
authors.affiliation: 1 Department of Biochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan.
authors.forename: Md Rafiqul Islam
authors.initials: MR
authors.lastname: Khan
authors.affiliation: 1 Department of Biochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan.
authors.forename: Junsuke
authors.initials: J
authors.lastname: Uwada
authors.affiliation: 3 National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Umezawa
authors.affiliation: 1 Department of Biochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Taniguchi
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D054339:Steroidogenic Factor 1 / Q000235:genetics / Q000378:metabolism*; D013256:Steroids / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D013256:Steroids
keywords: adrenal; gonad; liver receptor homolog-1; steroidogenesis; steroidogenic factor-1; transcriptional regulation