title: Heavy resistance training is safe and improves bone, function, and stature in postmenopausal women with low to very low bone mass: novel early findings from the LIFTMOR trial.
abstract: The aim of the LIFTMOR (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation) trial is to determine the safety and efficacy of brief, bone-targeted, high-intensity progressive resistance training (HiPRT) with impact loading for postmenopausal women with low bone mass. Preliminary findings indicate the LIFTMOR program is safe and effective.
  
  
  BACKGROUND
  Despite a lack of notable efficacy, exercise guidelines for osteoporosis typically recommend moderate-intensity exercises, owing to a perceived risk of fracture from high-intensity loading. Indeed, safety concerns alone have prevented the well-recognised preferential response of bone tissue to high-intensity loads from being applied to those who stand to benefit the most. To progress from this therapeutic stalemate, a challenge to conventional wisdom was required. Our goal was to examine the safety and efficacy of HiPRT and impact loading for risk factors of osteoporotic fracture in postmenopausal women with low to very low bone mass.
  
  
  METHODS
  Participants have been randomised to either 8 months of twice-weekly 30-min supervised HiPRT and impact loading or a low-intensity home-based exercise program of the same duration and dose. Testing at baseline and follow-up has included anthropometry; bone, muscle, and fat mass; and functional performance.
  
  
  RESULTS
  Twenty-eight women (66.1 ± 4.8 years, mean lumbar spine T-score -2.15 ± 0.72) have completed the study. HiPRT and impact loading (n = 12) improved height (0.4 ± 0.2 cm vs -0.3 ± 0.1 cm, p = 0.003), femoral neck bone mineral density (0.3 ± 0.5 % vs -2.5 ± 0.8 %, p = 0.016), lumbar spine bone mineral density (1.6 ± 0.9 % vs -1.7 ± 0.6 %, p = 0.005), and functional performance (p < 0.05), compared to controls (n = 16). Compliance has been >87 %. There have been no injuries.
  
  
  CONCLUSIONS
  Brief supervised HiPRT with impact loading is a safe and effective exercise therapy for postmenopausal women with low to very low bone mass.
authors.affiliation: School of Allied Health Sciences, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia.|Centre for Musculoskeletal Research, Menzies Health Institute Queensland, Gold Coast, Queensland, Australia.
authors.forename: S L
authors.initials: SL
authors.lastname: Watson
authors.affiliation: School of Allied Health Sciences, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia.|Centre for Musculoskeletal Research, Menzies Health Institute Queensland, Gold Coast, Queensland, Australia.
authors.forename: B K
authors.initials: BK
authors.lastname: Weeks
authors.affiliation: The Bone Clinic, Brisbane, Queensland, Australia.
authors.forename: L J
authors.initials: LJ
authors.lastname: Weis
authors.affiliation: School of Allied Health Sciences, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia.|Centre for Musculoskeletal Research, Menzies Health Institute Queensland, Gold Coast, Queensland, Australia.
authors.forename: S A
authors.initials: SA
authors.lastname: Horan
authors.affiliation: School of Allied Health Sciences, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia. b.beck@griffith.edu.au.|Centre for Musculoskeletal Research, Menzies Health Institute Queensland, Gold Coast, Queensland, Australia. b.beck@griffith.edu.au.|The Bone Clinic, Brisbane, Queensland, Australia. b.beck@griffith.edu.au.
authors.forename: B R
authors.initials: BR
authors.lastname: Beck
mesh_terms: D000368:Aged; D000886:Anthropometry / Q000379:methods; D001823:Body Composition / Q000502:physiology; D015519:Bone Density / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000503:physiopathology / Q000534:rehabilitation*; D058866:Osteoporotic Fractures / Q000209:etiology / Q000517:prevention & control; D010349:Patient Compliance / Q000706:statistics & numerical data; D055070:Resistance Training / Q000009:adverse effects / Q000379:methods*; D012307:Risk Factors; D016037:Single-Blind Method
keywords: Back extensor strength; Bone density; Exercise; Kyphosis; Lifting; Osteoporosis