title: CT pulmonary densitovolumetry in patients with acromegaly: a comparison between active disease and controlled disease.
abstract: OBJECTIVE
  Our purpose was to compare the findings of CT pulmonary densitovolumetry and pulmonary function in patients with active acromegaly and controlled acromegaly and, secondarily, to correlate these findings.
  
  
  METHODS
  11 patients with active acromegaly, 18 patients with controlled acromegaly and 17 control subjects, all non-smokers, underwent quantification of lung volume using multidetector CT (Q-MDCT) and pulmonary function tests.
  
  
  RESULTS
  Patients with active acromegaly had larger total lung mass (TLM) values than the controls and larger amounts of non-aerated compartments than the other two groups. Patients with active acromegaly also had larger amounts of poorly aerated compartments than the other two groups, a difference that was observed in both total lung volume (TLV) and TLM. TLV as measured by inspiratory Q-MDCT correlated significantly with total lung capacity, whereas TLV measured using expiratory Q-MDCT correlated significantly with functional residual capacity.
  
  
  CONCLUSIONS
  Patients with active acromegaly have more lung mass and larger amounts of non-aerated and poorly aerated compartments. There is a relationship between the findings of CT pulmonary densitovolumetry and pulmonary function test parameters.
  
  
  CONCLUSIONS
  Although the nature of our results demands further investigation, our data suggest that both CT pulmonary densitovolumetry and pulmonary function tests can be used as useful tools for patients with acromegaly by assisting in the prediction of disease activity.
authors.affiliation: 1 Post-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.|2 Department of Radiology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.|3 State Institute of Brain Paulo Niemeyer, Rio de Janeiro, Brazil.|4 Faculty of Medical and Health Sciences of Juiz de Fora (SUPREMA), Juiz de Fora, Brazil.
authors.forename: Gustavo B
authors.initials: GB
authors.lastname: Camilo
authors.affiliation: 5 Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.|6 Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luiz Coimbra Institute of Post-Graduation and Research in Engineering, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Alysson R S
authors.initials: AR
authors.lastname: Carvalho
authors.affiliation: 1 Post-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.|2 Department of Radiology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Dequitier C
authors.initials: DC
authors.lastname: Machado
authors.affiliation: 1 Post-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.|2 Department of Radiology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Mogami
authors.affiliation: 7 Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil.|8 Post-graduate Program in Clinical and Experimental Physiopathology (FISCLINEX), School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Melo
authors.affiliation: 1 Post-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.|9 Laboratory of Pulmonary Function, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Agnaldo J
authors.initials: AJ
authors.lastname: Lopes
mesh_terms: D000172:Acromegaly / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D012129:Respiratory Function Tests / Q000706:statistics & numerical data