title: Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all.
abstract: The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both healthy and cancer cells against the effects of treatment and contribute to the development of drug resistance. Therefore, anti-cancer treatments based on inflicting DNA damage can benefit from inhibition of DNA repair. Hyperthermia - treatment at elevated temperature - considerably affects DNA repair, among other cellular processes, and can thus sensitize (cancer) cells to DNA damaging agents. This effect has been known and clinically applied for many decades, but how heat inhibits DNA repair and which pathways are targeted has not been fully elucidated. In this review we attempt to summarize the known effects of hyperthermia on DNA repair pathways relevant in clinical treatment of cancer. Furthermore, we outline the relationships between the effects of heat on DNA repair and sensitization of cells to various DNA damaging agents.
authors.affiliation: Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands. a.l.oei@amc.uva.nl.|Department of Radiotherapy, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands. a.l.oei@amc.uva.nl.
authors.forename: Arlene L
authors.initials: AL
authors.lastname: Oei
authors.affiliation: Van Leeuwenhoek Centre for Advanced Microscopy (LCAM)-AMC, Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands. l.e.vriend@amc.uva.nl.
authors.forename: Lianne E M
authors.initials: LE
authors.lastname: Vriend
authors.affiliation: Department of Radiotherapy, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands. h.crezee@amc.uva.nl.
authors.forename: Johannes
authors.initials: J
authors.lastname: Crezee
authors.affiliation: Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands. n.a.franken@amc.uva.nl.|Department of Radiotherapy, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands. n.a.franken@amc.uva.nl.
authors.forename: Nicolaas A P
authors.initials: NA
authors.lastname: Franken
authors.affiliation: Van Leeuwenhoek Centre for Advanced Microscopy (LCAM)-AMC, Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands. p.krawczyk@amc.uva.nl.
authors.forename: Przemek M
authors.initials: PM
authors.lastname: Krawczyk
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D006801:Humans; D006979:Hyperthermia, Induced; D009369:Neoplasms / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents