title: Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities.
abstract: Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide -SO3/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one-step procedure has the power of providing a spectrum of xylomannans with varying molecular masses (<12-74kDa), sulfate content (1-50%) and glycosyl composition. Especially, the sulfated xylomannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parental compound (F1) and that too in the absence of drug-induced cytotoxicity. Regarding methodological facet, the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular mass and sugar composition during isolation by the used reagent opens a door for the production of new molecular entity with altered biological activity from other natural sources.
authors.affiliation: Natural Products Laboratory, Department of Chemistry, The University of Burdwan, West Bengal 713 104, India. Electronic address: ray_sayani1988@yahoo.co.uk.
authors.forename: Sayani
authors.initials: S
authors.lastname: Ray
authors.affiliation: Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales UBA, Ciudad Universitaria, Pabellón 2 Piso 4, 1428 Buenos Aires, Argentina.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Pujol
authors.affiliation: Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales UBA, Ciudad Universitaria, Pabellón 2 Piso 4, 1428 Buenos Aires, Argentina.
authors.forename: Elsa B
authors.initials: EB
authors.lastname: Damonte
authors.affiliation: Natural Products Laboratory, Department of Chemistry, The University of Burdwan, West Bengal 713 104, India.
authors.forename: Bimalendu
authors.initials: B
authors.lastname: Ray
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006027:Glycosides / Q000737:chemistry; D018259:Herpesvirus 1, Human / Q000187:drug effects; D008970:Molecular Weight; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D000461:Rhodophyta / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013431:Sulfates / Q000737:chemistry*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D006027:Glycosides; D009844:Oligosaccharides; D013431:Sulfates; C570461:xylomannan
keywords: Antiviral drug candidate; Cytotoxicity; Polysaccharide engineering; Scinaia hatei