title: Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses--A Case-Control Study.
abstract: OBJECTIVE
  Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses.
  
  
  METHODS
  A total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA.
  
  
  RESULTS
  Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly.
  
  
  CONCLUSIONS
  Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism.
authors.affiliation: Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Gao
authors.affiliation: Department of Clinical Medicine, Fudan University Shanghai Medical College, Shanghai, China.
authors.forename: Kairui
authors.initials: K
authors.lastname: Jin
authors.affiliation: Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Peihong
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Meili
authors.initials: M
authors.lastname: Yang
authors.affiliation: Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Yu
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018149:Glucose Intolerance / Q000473:pathology; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*; D019518:Postprandial Period; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood*
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001786:Blood Glucose; D036361:Peptide Hormones; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase