title: Development of Thyroid-Associated Ophthalmopathy in Patients Who Underwent Total Thyroidectomy.
abstract: OBJECTIVE
  To report clinical characteristics of thyroid-associated ophthalmopathy (TAO) in patients who previously underwent total thyroidectomy for thyroid cancer or a benign mass of the thyroid.
  
  
  METHODS
  Of the patients who were diagnosed with TAO from March 2008 to March 2012, we performed a retrospective chart review on those who had undergone total thyroidectomy for thyroid cancer or a benign mass of the thyroid before the occurrence of ophthalmopathy.
  
  
  RESULTS
  Of the 206 patients diagnosed with TAO, seven (3.4%) met the inclusion criteria. The mean age of the subjects was 47.4 years, and all were female. Six patients were diagnosed with papillary thyroid cancer, and one was diagnosed with a benign mass. The duration between total thyroidectomy and onset of TAO ranged from 3-120 months (median 48 months). Ophthalmic manifestations varied among cases. Except for the patient who was diagnosed with a benign mass, all patients showed hyperthyroid status and were under Synthroid hormone treatment at the time of TAO development. Five of these six patients had positive levels of thyroid-stimulating hormone (TSH) receptor autoantibodies.
  
  
  CONCLUSIONS
  TAO rarely develops after total thyroidectomy, and the mechanism of TAO occurrence is unclear. However, most patients showed abnormalities in thyroid function and TSH receptor autoantibodies.
authors.affiliation: Department of Ophthalmology, Soonchunhyang Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.|Department of Medicine, Yonsei University Graduate School of Medicine, Seoul, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Jang
authors.affiliation: Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Ka Hyun
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Soonchunhyang Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Jong Rok
authors.initials: JR
authors.lastname: Oh
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Bo Yeon
authors.initials: BY
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea. yoonjs@yuhs.ac.
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Yoon
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D002277:Carcinoma; D002291:Carcinoma, Papillary / Q000276:immunology / Q000601:surgery; D005260:Female; D049970:Graves Ophthalmopathy / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology / Q000473:pathology; D011989:Receptors, Thyrotropin; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000150:complications / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects / Q000379:methods*; D013972:Thyrotropin / Q000097:blood; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D011989:Receptors, Thyrotropin; D013972:Thyrotropin
keywords: TSH receptor autoantibody; Total thyroidectomy; thyroid benign mass; thyroid cancer; thyroid-associated orbitopathy