title: Current status of intratumoral therapy for glioblastoma.
abstract: With emerging drug delivery technologies becoming accessible, more options are expected to become available to patients with glioblastoma (GBM) in the near future. It is important for clinicians to be familiar with the underlying mechanisms and limitations of intratumoral drug delivery, and direction of recent research efforts. Tumor-adjacent brain is an extremely complex living matrix that creates challenges with normal tissue intertwining with tumor cells. For convection-enhanced delivery (CED), the role of tissue anisotropy for better predicting the biodistribution of the infusate has recently been studied. Computational predictive methods are now available to better plan CED therapy. Catheter design and placement—in addition to the agent being used—are critical components of any protocol. This paper overviews intratumoral therapies for GBM, highlighting key anatomic and physiologic perspectives, selected agents (especially immunotoxins), and some new developments such as the description of the glymphatic system.
authors.affiliation: Department of Neurosurgery, The University of Illinois at Chicago, 912 S. Wood St., Chicago, IL, 60612, USA. ankitm@uic.edu.
authors.forename: Ankit I
authors.initials: AI
authors.lastname: Mehta
authors.affiliation: Department of Neurosurgery, The University of Illinois at Chicago, 912 S. Wood St., Chicago, IL, 60612, USA.|Department of Bioengineering, The University of Illinois at Chicago, Chicago, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Linninger
authors.affiliation: Brain Tumor Center, The University of Chicago, Chicago, USA.
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Lesniak
authors.affiliation: Department of Neurosurgery, The University of Illinois at Chicago, 912 S. Wood St., Chicago, IL, 60612, USA.
authors.forename: Herbert H
authors.initials: HH
authors.lastname: Engelhard
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: Convection enhanced delivery; Gliadel; Glioblastoma multiforme; Intratumoral therapy