title: PRR11 Is a Prognostic Marker and Potential Oncogene in Patients with Gastric Cancer.
abstract: PRR11 is a potential candidate oncogene that has been implicated in the pathogenesis of lung cancer, however the role of PRR11 in gastric cancer is currently unclear. In the present study, we investigated the role of PRR11 in gastric cancer by evaluating its expression status in samples from a cohort of 216 patients with gastric cancer. PRR11 was found to be overexpressed in 107 (49.5%) patients by immunohistochemistry of tissue microarrays generated using the patient samples. Furthermore, PRR11 overexpression was found to correlate significantly with clinicopathologic features such as tumor invasion, tumor differentiation, and disease stage. Survival analysis of the cohort revealed that PRR11 is an independent prognostic factor for gastric cancer patients. PRR11 was stably silenced in a gastric carcinoma cell line using an shRNA-based approach, and treated cells showed decreased cellular proliferation and colony formation in vitro and cell growth in vivo, companied by decreased expression of CTHRC1 and increased expression of LXN, proteins involved in tumor progression. Evaluation of human gastric cancer samples demonstrated that PRR11 expression was also associated with increased CTHRC1 and decreased LXN expression. These data indicate that PRR11 may be widely activated in human gastric cancer and are consistent with the hypothesis that PRR11 functions as an oncogene in the development and progression of gastric cancer.
authors.affiliation: The Third Department of Oncology, The Second Affiliated Hospital of The Third Military Medical University, Chongqing, 400037, China.
authors.forename: Zongchang
authors.initials: Z
authors.lastname: Song
authors.affiliation: The Third Department of Oncology, The Second Affiliated Hospital of The Third Military Medical University, Chongqing, 400037, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Liu
authors.affiliation: The Third Department of Oncology, The Second Affiliated Hospital of The Third Military Medical University, Chongqing, 400037, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: The Third Department of Oncology, The Second Affiliated Hospital of The Third Military Medical University, Chongqing, 400037, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Zhang
authors.affiliation: The Third Department of Oncology, The Second Affiliated Hospital of The Third Military Medical University, Chongqing, 400037, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: The Third Department of Oncology, The Second Affiliated Hospital of The Third Military Medical University, Chongqing, 400037, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Yuan
authors.affiliation: The Third Department of Oncology, The Second Affiliated Hospital of The Third Military Medical University, Chongqing, 400037, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Medical Oncology, Shanghai East Hospital, Shanghai, 200120, China; Department of Medical Oncology, Changzheng Hospital, Shanghai, 200070, China.
authors.forename: Guanzhen
authors.initials: G
authors.lastname: Yu
authors.affiliation: The Third Department of Oncology, The Second Affiliated Hospital of The Third Military Medical University, Chongqing, 400037, China.
authors.forename: Yide
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009857:Oncogenes; D011379:Prognosis; D011506:Proteins / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D014410:Tumor Stem Cell Assay; D015854:Up-Regulation / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C502426:CTHRC1 protein, human; D016326:Extracellular Matrix Proteins; C524815:PRR11 protein, human; D011506:Proteins