title: Copper complexes as a source of redox active MRI contrast agents.
abstract: The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.
authors.affiliation: Department of Pure & Applied Chemistry, Strathclyde University, 295 Cathedral St., Glasgow, G1 1XL, UK.
authors.forename: Lynsey
authors.initials: L
authors.lastname: Dunbar
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University, 27 Taylor Street, Glasgow, G4 0NR, UK.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Sowden
authors.affiliation: Department of Pure & Applied Chemistry, Strathclyde University, 295 Cathedral St., Glasgow, G1 1XL, UK.
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Trotter
authors.affiliation: Department of Pure & Applied Chemistry, Strathclyde University, 295 Cathedral St., Glasgow, G1 1XL, UK.|School of Science and Technology, University of New England, Armidale, NSW 2351, Australia.
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Taylor
authors.affiliation: Department of Pure & Applied Chemistry, Strathclyde University, 295 Cathedral St., Glasgow, G1 1XL, UK.
authors.forename: David
authors.initials: D
authors.lastname: Smith
authors.affiliation: Department of Pure & Applied Chemistry, Strathclyde University, 295 Cathedral St., Glasgow, G1 1XL, UK.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.affiliation: Department of Pure & Applied Chemistry, Strathclyde University, 295 Cathedral St., Glasgow, G1 1XL, UK. j.reglinski@strath.ac.uk.
authors.forename: John
authors.initials: J
authors.lastname: Reglinski
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University, 27 Taylor Street, Glasgow, G4 0NR, UK.|School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.
authors.forename: Corinne M
authors.initials: CM
authors.lastname: Spickett
mesh_terms: D003287:Contrast Media / Q000737:chemistry* / Q000627:therapeutic use; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry* / Q000627:therapeutic use; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D010084:Oxidation-Reduction
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D028581:Lanthanoid Series Elements; D003300:Copper
keywords: Copper macrocycles; Imaging; Inflammation; Oxidation–reduction; Redox sensitive contrast agent