title: An efficient synthesis of novel bis-triazole glycoconjugates via a three-component condensation as a key reaction.
abstract: Novel bis-triazole glycoconjugates were designed and prepared successfully via 5 steps from propargyl per-O-acetyl-β-d-glucoside or xyloside (total yield of 48-53%), after utilizing a three-component condensation of propargyl per-O-acetyl-β-d-glycoside, formaldehyde, and sodium azide as a key step to synthesize 2-hydroxymethyl-2H-1,2,3-triazole glycoconjugates. The developed bis-triazole glycoconjugates would be crucial in antivirus pharmacology and chemical biology.
authors.affiliation: Office of Scientific Research, Anhui Provincial Institute for Food and Drug Control, Hefei 230022, China. Electronic address: chengjie_234@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Cheng
authors.affiliation: School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China.
authors.forename: Zhenlong
authors.initials: Z
authors.lastname: Gu
authors.affiliation: School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China.
authors.forename: Caiyu
authors.initials: C
authors.lastname: He
authors.affiliation: School of Materials and Chemical Engineering, Anhui Jianzhu University, Hefei 230601, China. Electronic address: jinjie@ahjzu.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
authors.affiliation: School of Foreign Studies, Heifei University of Technology, Hefei 230009, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China.
authors.forename: Guojun
authors.initials: G
authors.lastname: Li
authors.affiliation: Office of Scientific Research, Anhui Provincial Institute for Food and Drug Control, Hefei 230022, China. Electronic address: 13955147703@163.com.
authors.forename: Bei
authors.initials: B
authors.lastname: Sun
authors.affiliation: Office of Scientific Research, Anhui Provincial Institute for Food and Drug Control, Hefei 230022, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Office of Scientific Research, Anhui Provincial Institute for Food and Drug Control, Hefei 230022, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Bai
mesh_terms: D003500:Cyclization; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D006001:Glycoconjugates; D014230:Triazoles
keywords: 1,2,3-Triazole; 1,3-Dipolar cycloaddition; Glycoconjugate; Multicomponent reaction