title: Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety.
abstract: In this study, we have performed the synthesis of new N'-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a-s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target compounds were prepared by a three step synthetic procedure starting from 2-mercaptobenzothiazole. The structures of the target compounds were elucidated by IR, (1)H NMR, (13)C NMR spectra and elemental analysis. The antifungal activity of the obtained compounds has been determined against a number of clinic and fluconazole-resistant Candida strains by using microdilution method. Compounds (3a-3s) exhibited anticandidal activity in different ratios varying between the range of MIC: 50 and 200 µg/mL.
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Leyla
authors.initials: L
authors.lastname: Yurttaş
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Zafer Asım
authors.initials: ZA
authors.lastname: Kaplancıklı
authors.affiliation: b Department of Pharmacognosy , Graduate School of Health Sciences, Anadolu University , Eskişehir , Turkey , and.
authors.forename: Gamze
authors.initials: G
authors.lastname: Göger
authors.affiliation: c Faculty of Health Sciences , Anadolu University , Eskişehir , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirci
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D025141:Drug Resistance, Fungal / Q000187:drug effects; D015725:Fluconazole; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000935:Antifungal Agents; D052160:Benzothiazoles; D006835:Hydrazones; D015725:Fluconazole
keywords: 2-Mercaptobenzothiazole; anticandidal; antifungal; hydrazone