title: Extracorporeal life support in the treatment of colchicine poisoning.
abstract: BACKGROUND
  Ingestions of Colchicum autumnale may lead to severe poisoning. It begins with gastrointestinal symptoms and leukocytosis, followed by multi-organ failure with shock and a possible late recovery phase. Mortality is highly dependent on the ingested dose. We report a case of accidental C. autumnale poisoning with refractory cardiogenic shock and eventual survival after extracorporeal life support (ECLS).
  
  
  METHODS
  A 68-year-old woman was admitted to the intensive care unit (ICU) on day 3 after ingestion of C. autumnale in a meal. She first suffered from nausea and vomiting leading to severe dehydration. She then developed multi-organ failure and refractory cardiogenic shock, with a mean arterial pressure nadir of 50 mmHg despite high doses of catecholamines and a left ventricular ejection fraction at 5-10%. Venous-arterial ECLS was therefore started at an initial rate of 3.5 L/min and 3,800 rev/min. Her symptoms also included pancytopenia on day 4 with diffuse bleeding requiring iterative blood product transfusion. Platelet and leukocyte count nadirs were 13 × 10(9)/L (normal range: 150-400 × 10(9)/L) and 0.77 × 10(9)/L (normal range: 4.2-10.7 × 10(9)/L), respectively. ECLS allowed good cardiac contractility recovery within a few days, with complications including bleeding made controllable. Indeed, because of hemostasis disorders, the patient presented hemoptysis and hematuria. She was treated with tranexamic acid and transfused with blood products. She received 15 erythrocyte concentrates, 13 platelet concentrates, and 7 fresh frozen plasma. ECLS was removed by day 10, with subsequent weaning from mechanical ventilation as well as from hemodialysis in the following days.
  
  
  CONCLUSIONS
  This patient survives after the use of ECLS in Colchicum poisoning, with controllable complications. Thus, ECLS might be indicated to overcome the potentially refractory cardiogenic shock phase.
authors.affiliation: Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpital Universitaires de Strasbourg , Strasbourg (France).
authors.forename: Julie
authors.initials: J
authors.lastname: Boisramé-Helms
authors.forename: Hassène
authors.initials: H
authors.lastname: Rahmani
authors.forename: Laure
authors.initials: L
authors.lastname: Stiel
authors.forename: Christine
authors.initials: C
authors.lastname: Tournoud
authors.forename: Philippe
authors.initials: P
authors.lastname: Sauder
mesh_terms: D000368:Aged; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001803:Blood Transfusion; D003078:Colchicine / Q000506:poisoning*; D003079:Colchicum / Q000506:poisoning*; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects; D005260:Female; D006801:Humans; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D011041:Poisoning / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D020127:Recovery of Function; D006435:Renal Dialysis; D012121:Respiration, Artificial; D012770:Shock, Cardiogenic / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D003078:Colchicine
keywords: Cardiogenic shock; Colchicine poisoning; ECLS