title: Uncommon isolated distant subcutaneous tissue and skeletal muscle metastasis from oesophageal cancer diagnosed by PET/CT (18)F-FDG.
abstract: Distant soft-tissue metastases (subcutaneous tissues and skeletal muscle) are extremely rare, particularly in oesophageal carcinoma. The case is described of a patient who was treated for oesophageal adenocarcinoma 2.5 years previously. A PET/CT was performed showing metastatic spread due to a solitary focus of increased tracer uptake corresponding to one subcutaneous node in the upper abdomen. An excisional biopsy showed a metastasis from the carcinoma. Restaging PET/CT (18)F-FDG study was performed 2 year later, demonstrating foci of increased uptake within several muscles as isolated distant haematogenous spread of metastases, histopathologically confirmed. As most of soft-tissue metastases are asymptomatic, the physicians should recommend a histopathological study of focal FDG uptake at subcutaneous tissues and/or skeletal muscles, because they may be the first sign of disease spread, so therapeutic management of these patients could be changed.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Infanta Cristina», Badajoz, España. Electronic address: mluzovi@yahoo.es.
authors.forename: M L
authors.initials: ML
authors.lastname: Domínguez
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Infanta Cristina», Badajoz, España.
authors.forename: J I
authors.initials: JI
authors.lastname: Rayo
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Infanta Cristina», Badajoz, España.
authors.forename: J
authors.initials: J
authors.lastname: Serrano
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Infanta Cristina», Badajoz, España.
authors.forename: J R
authors.initials: JR
authors.lastname: Infante
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Infanta Cristina», Badajoz, España.
authors.forename: L
authors.initials: L
authors.lastname: García
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Infanta Cristina», Badajoz, España.
authors.forename: M
authors.initials: M
authors.lastname: Moreno
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000628:therapy; D005462:Fluorine Radioisotopes / Q000032:analysis / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18 / Q000032:analysis / Q000493:pharmacokinetics; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals / Q000032:analysis / Q000493:pharmacokinetics; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary*; D040521:Subcutaneous Tissue / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Cáncer esófago; Metástasis muscular; Metástasis subcutánea; Muscle metastasis; Oesophageal cancer; PET-TAC (18)F-FDG; PET/CT (18)F-FDG; Subcutaneous metastasis