title: Distinct patterns of spontaneous brain activity between children and adults with anisometropic amblyopia: a resting-state fMRI study.
abstract: OBJECTIVE
  To detect the altered spontaneous brain activity patterns in children and adults with anisometropic amblyopia using resting-state functional magnetic resonance imaging (rs-fMRI) technique combined with the amplitude of low-frequency fluctuation (ALFF) method.
  
  
  METHODS
  Thirty-two monocular anisometropic amblyopia and 34 normal-sight controls were divided into child group and adult group. Rs-fMRI was performed in all participants and analysis of ALFF value within the whole brain was conducted in each subject. ALFF value differences between the patients and controls in the two groups were compared via an independent two-sample t test.
  
  
  RESULTS
  The amblyopic children mainly exhibited increased ALFF in part of the bilateral calcarine (BA17), the left middle occipital gyrus (BA18/19), and the left postcentral gyrus (BA2). By contrast, the amblyopic adults showed decreased ALFF in the bilateral precuneus cortex (part of BA7), and the standardized ALFF value of bilateral precuneus were correlated with the amount of anisometropia of the amblyopic adults.
  
  
  CONCLUSIONS
  Rs-fMRI is an effective noninvasive technique for exploring brain activity of the anisometropic amblyopia. Our findings demonstrated that brain activity changed both in amblyopic children and adults under the resting state, and revealed the differences in spontaneous activity patterns between the amblyopic children and adults.
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Minglong
authors.initials: M
authors.lastname: Liang
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xie
authors.affiliation: Ophthalmology Research Center, Southwest Eye Hospital/Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.|Department of Radiology, 401st Hospital of PLA, Qingdao, Shandong Province, China.
authors.forename: Longhua
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Xuntao
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Luqing
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. wangjian_811@yahoo.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000550:Amblyopia / Q000503:physiopathology*; D001927:Brain Diseases / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000503:physiopathology; D011597:Psychomotor Performance; D014792:Visual Acuity / Q000502:physiology; D014793:Visual Cortex / Q000503:physiopathology*; D055815:Young Adult
keywords: ALFF; Anisometropic amblyopia; Resting-state fMRI