title: Cell Cycle Rules Pluripotency.
abstract: Stem cell self-renewal is intrinsically associated with cell cycle control. However, the precise mechanisms coordinating cell fate choices and cell cycle remain to be fully uncovered. Now in Cell, Gonzales et al. (2015) and colleagues demonstrate that factors controlling the G2/M phase are necessary to block pluripotency upon induction of differentiation.
authors.affiliation: Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, West Forvie Site, Robinson Way, Cambridge, CB2 0SZ, UK; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK. Electronic address: lv225@cam.ac.uk.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Vallier
mesh_terms: D002453:Cell Cycle; D053595:Embryonic Stem Cells / Q000166:cytology*; D053263:Gene Regulatory Networks; D006801:Humans