title: Improved gait in persons with knee related mobility limitations by a rosehip food supplement: A randomized, double-blind, placebo-controlled trial.
abstract: OBJECTIVE
  To evaluate the efficacy of a specialized rosehip powder nutraceutical on the biomechanical function of the knee joint during walking in individuals with knee-related walking limitations.
  
  
  METHODS
  Randomized, participant and outcome assessor blinded trial. Participants with self-reported knee-related walking limitations were randomized (1:1) to receive three capsules/day of either rosehip powder or identically appearing placebo capsules for 12 weeks. At baseline and the 12 weeks follow-up, 3-dimensional gait analyses were performed from which the peak resultant knee moment was selected as primary outcome. Secondary outcomes included sagittal and frontal plane knee joint moments, knee joint kinematics, peaks in the vertical ground reaction forces, and self-selected walking speeds. Analyses were based on ANCOVA with the 'Intention-To-Treat' (ITT) population, defined as all randomized participants using last observation carried forward imputation for missing data.
  
  
  RESULTS
  100 participants were randomized to rosehip (n=50) or placebo (n=50) and defined the ITT population. Of these 94 completed the study (47 in each group). There were statistically significant group differences in the change from baseline in the primary outcome: the resultant knee moment (0.06 nm/kg, 95%CI: 0.00-0.12; P=0.039) and in the peaks in the sagittal plane moments and kinematics during the stance phase of walking with the rosehip group exhibiting greater joint moments and more knee joint flexion during walking than the placebo group.
  
  
  CONCLUSIONS
  A daily intake of rosehip powder for 12 weeks improved important indices of knee joint function and dynamics during walking compared to placebo in persons with knee-related walking limitations.
authors.affiliation: The Parker Institute, Department of Rheumatology, Copenhagen University Hospitals at Bispebjerg-Frederiksberg, Copenhagen, Denmark.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ginnerup-Nielsen
authors.affiliation: The Parker Institute, Department of Rheumatology, Copenhagen University Hospitals at Bispebjerg-Frederiksberg, Copenhagen, Denmark.
authors.forename: Robin
authors.initials: R
authors.lastname: Christensen
authors.affiliation: The Parker Institute, Department of Rheumatology, Copenhagen University Hospitals at Bispebjerg-Frederiksberg, Copenhagen, Denmark.
authors.forename: Henning
authors.initials: H
authors.lastname: Bliddal
authors.affiliation: The Parker Institute, Department of Rheumatology, Copenhagen University Hospitals at Bispebjerg-Frederiksberg, Copenhagen, Denmark.
authors.forename: Graziella
authors.initials: G
authors.lastname: Zangger
authors.affiliation: The Parker Institute, Department of Rheumatology, Copenhagen University Hospitals at Bispebjerg-Frederiksberg, Copenhagen, Denmark.
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Hansen
authors.affiliation: The Parker Institute, Department of Rheumatology, Copenhagen University Hospitals at Bispebjerg-Frederiksberg, Copenhagen, Denmark. Electronic address: marius.henriksen@regionh.dk.
authors.forename: Marius
authors.initials: M
authors.lastname: Henriksen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005684:Gait / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology* / Q000627:therapeutic use; D027826:Rosa; D057566:Self Report; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology*
chemical_list: D028321:Plant Preparations
keywords: Dietary supplements; Gait; Knee pain; Randomized trial