title: Coexpression of androgen receptor and FOXA1 in nonmetastatic triple-negative breast cancer: ancillary study from PACS08 trial.
abstract: OBJECTIVE
  Microarray studies identified a subgroup of molecular apocrine tumors (estrogen receptor [ER] negative/androgen receptor [AR] positive) that express luminal genes including FOXA1. FOXA1 may direct AR to sites normally occupied by ER in luminal tumors, inducing an estrogen-like gene program that stimulated proliferation.
  
  
  METHODS
  Expression of AR and FOXA1 was evaluated by immunohistochemistry in 592 patients with nonmetastatic triple-negative breast cancer (TNBC).
  
  
  RESULTS
  Coexpression of AR and FOXA1 was found in 15.2% of patients. These tumors were more frequently lobular, found in older patients and exhibited a lower nuclear grade and a greater degree of node involvement. They less often exhibited lymphocytic infiltrate, pushing margins, syncytial architecture, central fibrosis or necrosis.
  
  
  CONCLUSIONS
  TNBC with coexpression of AR and FOXA1 seems to behave like luminal tumors with a morphological profile distinct from other TNBC. These biomarkers could be useful to identify a subgroup of TNBC and could have future therapeutic implications.
authors.affiliation: Department of Medical Oncology, Institut du Cancer de Montpellier, 208 avenue des Apothicaires, 34298 Montpellier Cedex 5, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Guiu
authors.affiliation: Department of Pathology, Georges-François Leclerc Cancer Center, 1 rue du Professeur Marion, 21000 Dijon, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Charon-Barra
authors.affiliation: Methodological and Quality of Life in Oncology Unit, EA 3181, University Hospital of Besançon, 2 place Saint-Jacques, 25000 Besançon, France.
authors.forename: Déwi
authors.initials: D
authors.lastname: Vernerey
authors.affiliation: Department of Medical Oncology, Georges-François Leclerc Cancer Center, 1 rue du Professeur Marion, 21000 Dijon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fumoleau
authors.affiliation: Department of Medical Oncology, ICO Centre René Gauducheau, boulevard Jacques Monod, 44805 Saint Herblain, France.
authors.forename: Mario
authors.initials: M
authors.lastname: Campone
authors.affiliation: Department of Medical Oncology, Institut Gustave Roussy, 114 rue Edouard-Vaillant, 94800 Villejuif, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Spielmann
authors.affiliation: Department of Medical Oncology, Institut Claudius Régaud, 20/24 Rue du Pont Saint Pierre, 31300 Toulouse, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Roché
authors.affiliation: R&D UNICANCER, 101 rue de Tolbiac, 75654 Paris, France.
authors.forename: Christel
authors.initials: C
authors.lastname: Mesleard
authors.affiliation: Department of Pathology, Georges-François Leclerc Cancer Center, 1 rue du Professeur Marion, 21000 Dijon, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Arnould
authors.affiliation: R&D UNICANCER, 101 rue de Tolbiac, 75654 Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lemonnier
authors.affiliation: Department of Pathology, Institut Claudius Régaud, 20/24 rue du Pont Saint Pierre, 31300 Toulouse, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Lacroix-Triki
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D015870:Gene Expression; D051541:Hepatocyte Nuclear Factor 3-alpha / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D047368:Tumor Burden
chemical_list: C410798:AR protein, human; C496499:FOXA1 protein, human; D051541:Hepatocyte Nuclear Factor 3-alpha; D011944:Receptors, Androgen
keywords: FOXA1; androgen receptor; molecular apocrine tumors; triple-negative breast cancer