title: The role of endoplasmic reticulum stress and insulin resistance in the occurrence of goose fatty liver.
abstract: In mammals, insulin resistance (IR) is required for the occurrence of non-alcoholic fatty liver disease, and endoplasmic reticulum stress (ERS) contributes to IR. As geese have physiological and metabolic characteristics different from mammals, it is unclear whether these mechanisms also underlie the occurrence of goose fatty liver. To address this, 70-day-old geese were treated with an ERS inducer or overfed, and variables associated with ERS or IR were subsequently determined. The data indicated that the group of geese treated with the ERS inducer for 20d appeared to be more intolerant to blood glucose than the control group, and their livers showed features of hepatic steatosis, suggesting ERS can induce IR and hepatic steatosis in geese. In contrast, overfeeding did not induce ERS, probably due to the upregulated expression of fatty acid desaturases, but induced higher fasting/postprandial blood glucose as well as glucose intolerance in geese, which was accompanied by a dramatic increase of liver weight. Taken together, these findings delineated the role of ERS and IR in the occurrence of goose fatty liver.
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China; Institute of Epigenetics and Epigenomics, Yangzhou University, Yangzhou, 225009, PR China. Electronic address: tygeng@yzu.edu.cn.
authors.forename: Tuoyu
authors.initials: T
authors.lastname: Geng
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Xia
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China.
authors.forename: Fuyuan
authors.initials: F
authors.lastname: Li
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xia
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China.
authors.forename: Biao
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Botany, University of British Columbia, 6270 University Boulevard, British Columbia, V6T 1Z4, Canada.
authors.forename: Sean
authors.initials: S
authors.lastname: Montgomery
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China; Institute of Epigenetics and Epigenomics, Yangzhou University, Yangzhou, 225009, PR China.
authors.forename: Hengmi
authors.initials: H
authors.lastname: Cui
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, PR China. Electronic address: yzgong@163.com.
authors.forename: Daoqing
authors.initials: D
authors.lastname: Gong
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000009:adverse effects; D000091342:Endoplasmic Reticulum Chaperone BiP; D059865:Endoplasmic Reticulum Stress / Q000235:genetics*; D005234:Fatty Liver / Q000209:etiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005777:Geese; D015870:Gene Expression; D018149:Glucose Intolerance / Q000235:genetics; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D004268:DNA-Binding Proteins; D004041:Dietary Fats; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors
keywords: Endoplasmic reticulum stress; Goose; Insulin resistance; Non-alcoholic fatty liver disease; Overfeeding; Tunicamycin