title: Mesoporous-Silica-Functionalized Nanoparticles for Drug Delivery.
abstract: The ever-growing interest for finding efficient and reliable methods for treatment of diseases has set a precedent for the design and synthesis of new functional hybrid materials, namely porous nanoparticles, for controlled drug delivery. Mesoporous silica nanoparticles (MSNPs) represent one of the most promising nanocarriers for drug delivery as they possess interesting chemical and physical properties, thermal and mechanical stabilities, and are biocompatibile. In particular, their easily functionalizable surface allows a large number of property modifications further improving their efficiency in this field. This Concept article deals with the advances on the novel methods of functionalizing MSNPs, inside or outside the pores, as well as within the walls, to produce efficient and smart drug carriers for therapy.
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR-5253, ENSCM, Université Montpellier, CNRS, 8 Rue de l'École Normale, 34296 Montpellier cedex 5 (France).
authors.forename: Simon
authors.initials: S
authors.lastname: Giret
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR-5253, ENSCM, Université Montpellier, CNRS, 8 Rue de l'École Normale, 34296 Montpellier cedex 5 (France).
authors.forename: Michel
authors.initials: M
authors.lastname: Wong Chi Man
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR-5253, ENSCM, Université Montpellier, CNRS, 8 Rue de l'École Normale, 34296 Montpellier cedex 5 (France). carole.carcel@enscm.fr.
authors.forename: Carole
authors.initials: C
authors.lastname: Carcel
mesh_terms: D055598:Chemical Phenomena; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide
keywords: drug delivery; mesoporous silica; nanoparticles; surface functionalization; targeting