title: The interaction of Apolipoprotein A5 gene promoter region T-1131C polymorphism (rs12286037) and lifestyle modification on plasma triglyceride levels in Japanese.
abstract: OBJECTIVE
  Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program.
  
  
  METHODS
  A three-month lifestyle modification program was conducted with 297 participants (Age: 57 ± 8 years) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification.
  
  
  RESULTS
  Even after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, 126 ± 68 mg/dl; TC, 134 ± 74 mg/dl; and CC, 172 ± 101 mg/dl. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: -21.9 ± 61.0 mg/dl, -20.9 ± 51.0 mg/dl, and -42.6 ± 78.5 mg/dl, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels.
  
  
  CONCLUSIONS
  The genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.
authors.affiliation: Department of Environmental and Preventive Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamasaki
authors.affiliation: Department of Nutrition, School of Public Health, Faculty of Medicine, University of Kinshasa, B.P. 127 Kinshasa XI, Democratic Republic of Congo.
authors.forename: Paulin Beya Wa Bitadi
authors.initials: PB
authors.lastname: Mutombo
authors.affiliation: Department of Environmental and Preventive Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Iwamoto
authors.affiliation: Department of Human Nutrition, Faculty of Nursing and Human Nutrition, Yamaguchi Prefectural University, Yamaguchi 753-8502, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nogi
authors.affiliation: Department of Environmental Physiology, Faculty of Medicine, Shimane University, Shimane 693-8501, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Functional Pathology, Faculty of Medicine, Shimane University, Shimane 693-8501, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Nabika
authors.affiliation: Shimane University, Shimane 690-8504, Japan.
authors.forename: Kuninori
authors.initials: K
authors.lastname: Shiwaku
keywords: APOA5 T-1131C; Plasma TG; energy balance; lifestyle modification