title: Current and emerging modalities for detection of cardiotoxicity in cardio-oncology.
abstract: Advancements in diagnostic tools and curative-intent therapies have improved cancer-specific survival. With prolonged survival, patients are now subject to increased aging and development of cardiovascular risk factors such that further improvements in cancer-specific mortality are at risk of being offset by increased cardiovascular mortality. Moreover, established and novel adjuvant therapies used in cancer treatment are associated with unique and varying degrees of direct as well as indirect myocardial and cardiovascular injury (i.e., cardiotoxicity). Current approaches for evaluating anticancer therapy-induced injury have limitations, particularly lack of sensitivity for early detection of subclinical cardiac and cardiovascular dysfunction. With emerging evidence suggesting early prevention and treatment can mitigate the degree of cardiotoxicity and limit interruption of life-saving cancer therapy, the importance of early detection is increasingly paramount. Newer imaging modalities, functional capacity testing and blood biomarkers have the potential to improve early detection of cardiotoxicity and reduce cardiovascular morbidity and mortality.
authors.affiliation: Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Michel G
authors.initials: MG
authors.lastname: Khouri
authors.affiliation: Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Klein
authors.affiliation: Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Velazquez
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Lee W
authors.initials: LW
authors.lastname: Jones
mesh_terms: D057791:Cardiac Imaging Techniques; D066126:Cardiotoxicity / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D003935:Diagnostic Techniques, Cardiovascular; D006801:Humans; D009369:Neoplasms / Q000628:therapy*
keywords: anthracyclines; biomarkers; cardiotoxicity; chemotherapy; echocardiography; imaging; stress testing; trastuzumab