title: Abnormal functional global and local brain connectivity in female patients with anorexia nervosa.
abstract: BACKGROUND
  Previous resting-state functional connectivity studies in patients with anorexia nervosa used independent component analysis or seed-based connectivity analysis to probe specific brain networks. Instead, modelling the entire brain as a complex network allows determination of graph-theoretical metrics, which describe global and local properties of how brain networks are organized and how they interact.
  
  
  METHODS
  To determine differences in network properties between female patients with acute anorexia nervosa and pairwise matched healthy controls, we used resting-state fMRI and computed well-established global and local graph metrics across a range of network densities.
  
  
  RESULTS
  Our analyses included 35 patients and 35 controls. We found that the global functional network structure in patients with anorexia nervosa is characterized by increases in both characteristic path length (longer average routes between nodes) and assortativity (more nodes with a similar connectedness link together). Accordingly, we found locally decreased connectivity strength and increased path length in the posterior insula and thalamus.
  
  
  CONCLUSIONS
  The present results may be limited to the methods applied during preprocessing and network construction.
  
  
  CONCLUSIONS
  We demonstrated anorexia nervosa-related changes in the network configuration for, to our knowledge, the first time using resting-state fMRI and graph-theoretical measures. Our findings revealed an altered global brain network architecture accompanied by local degradations indicating wide-scale disturbance in information flow across brain networks in patients with acute anorexia nervosa. Reduced local network efficiency in the thalamus and posterior insula may reflect a mechanism that helps explain the impaired integration of visuospatial and homeostatic signals in patients with this disorder, which is thought to be linked to abnormal representations of body size and hunger.
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Daniel
authors.initials: D
authors.lastname: Geisler
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Viola
authors.initials: V
authors.lastname: Borchardt
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Anton R
authors.initials: AR
authors.lastname: Lord
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Ilka
authors.initials: I
authors.lastname: Boehm
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Franziska
authors.initials: F
authors.lastname: Ritschel
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Johannes
authors.initials: J
authors.lastname: Zwipp
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Sabine
authors.initials: S
authors.lastname: Clas
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Joseph A
authors.initials: JA
authors.lastname: King
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Silvia
authors.initials: S
authors.lastname: Wolff-Stephan
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Veit
authors.initials: V
authors.lastname: Roessner
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Martin
authors.initials: M
authors.lastname: Walter
authors.affiliation: From the Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Geisler, Boehm, Ritschel, Zwipp, Clas, King, Roessner, Ehrlich); the Leibniz Institute for Neurobiology, Magdeburg, Germany (Borchardt, Lord, Walter); the Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany (Borchardt, Lord, Walter); the Department of Psychosomatic Medicine and Psychotherapy, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Germany (Wolff-Stephan); the Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany (Walter); the Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany (Walter); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Mass. ( Ehrlich); and the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass. (Ehrlich).
authors.forename: Stefan
authors.initials: S
authors.lastname: Ehrlich
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000856:Anorexia Nervosa / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009434:Neural Pathways / Q000503:physiopathology; D012146:Rest; D055815:Young Adult