title: Chiral Bicyclic Guanidine-Catalyzed Enantioselective Sulfenylation of Oxindoles and Benzofuran-2(3H)-ones.
abstract: A chiral bicyclic guanidine-catalyzed enantioselective sulfenylation of 3-substituted oxindoles to N-(sulfanyl)succinimides has been developed. A series of unprecedented 3-sulfenylated oxindoles, such as 3-benzyl/alkyl-substituted 3-benzyl/alkyloxindoles, were obtained with high enantioselectivities (up to 98% ee). This methodology is also effective for the first asymmetric sulfenylation of benzofuran-2(3H)-ones, providing 3-benzyl-3-benzylthio-substituted benzofuran-2(3H)-ones with satisfactory results (up to 95% ee).
authors.affiliation: Institute of Chemical Biology, Henan University , Kaifeng, Henan, 475004, P. R. China.|Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, 475004, P. R. China.
authors.forename: Lisha
authors.initials: L
authors.lastname: Huang
authors.affiliation: Institute of Chemical Biology, Henan University , Kaifeng, Henan, 475004, P. R. China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, 475004, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Division of Chemistry and Biological Chemistry, Nanyang Technological University , 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Ye
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, 475004, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Chemical Biology, Henan University , Kaifeng, Henan, 475004, P. R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yan
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, 475004, P. R. China.|Division of Chemistry and Biological Chemistry, Nanyang Technological University , 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Choon-Hong
authors.initials: CH
authors.lastname: Tan
authors.affiliation: Institute of Chemical Biology, Henan University , Kaifeng, Henan, 475004, P. R. China.|Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, 475004, P. R. China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Liu
authors.affiliation: Institute of Chemical Biology, Henan University , Kaifeng, Henan, 475004, P. R. China.|Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, 475004, P. R. China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Jiang