title: Pregnancy related changes in human salivary secretion and composition in a Nigerian population.
abstract: BACKGROUND
  A variety of physiological changes occurring during pregnancy has been shown to affect the oral health. Saliva is critical for preserving and maintaining the health of oral tissues and has been used as a source of non-invasive investigation of different conditions in human and animal studies.
  
  
  OBJECTIVE
  This study was designed to evaluate changes in secretion and composition of saliva in pregnant women in a Nigerian population.
  
  
  METHODS
  This was a descriptive cross-sectional study using purposive sampling technique. Saliva samples were collected from 50 pregnant and age matched 50 non-pregnant women. Salivary flow rate, pH, total protein and concentrations of sodium, potassium, calcium, phosphate and bicarbonate were determined and compared using paired independent sample t test.
  
  
  RESULTS
  Salivary pH,mean concentrations of potassium and bicarbonate were significantly reduced while mean concentrations of salivary sodium and phosphate were significantly elevated in pregnant women compared to non-pregnant women (P < 0.05). However, there was no significant difference in the salivary flow rate, concentrations of total protein and calcium.
  
  
  CONCLUSIONS
  Salivary pH, bicarbonate and potassium concentrations were reduced while sodium and phosphate concentrations were elevated in pregnant women. These findings suggest that pregnant women may be predisposed to higher caries incidence.
authors.forename: T J
authors.initials: TJ
authors.lastname: Lasisi
authors.forename: P N
authors.initials: PN
authors.lastname: Ugwuadu
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009549:Nigeria; D011188:Potassium / Q000378:metabolism; D011247:Pregnancy / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D055815:Young Adult
chemical_list: D004573:Electrolytes; D012471:Salivary Proteins and Peptides; D012964:Sodium; D011188:Potassium