title: An Alternative Synthetic Approach to 3-Alkylated/Arylated 5-Nitropyridines.
abstract: An alternative method for the synthesis of 3-alkylated/arylated 5-nitropyridines was developed involving a three-component ring transformation of 3,5-dinitro-2-pyridone on treatment with aldehyde in the presence of ammonium acetate. This method facilitates the modification of the substituent at the 3-position by changing the precursor aldehyde. The use of solid ammonium acetate instead of ammonia as the nitrogen source renders the synthetic method more practical and user-friendly.
authors.affiliation: School of Environmental Science and Engineering, and ‡Research Center for Material Science and Engineering, Kochi University of Technology , Tosayamada, Kami, Kochi 782-8502, Japan.
authors.forename: Song Thi
authors.initials: ST
authors.lastname: Le
authors.affiliation: School of Environmental Science and Engineering, and ‡Research Center for Material Science and Engineering, Kochi University of Technology , Tosayamada, Kami, Kochi 782-8502, Japan.
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Asahara
authors.affiliation: School of Environmental Science and Engineering, and ‡Research Center for Material Science and Engineering, Kochi University of Technology , Tosayamada, Kami, Kochi 782-8502, Japan.
authors.forename: Nagatoshi
authors.initials: N
authors.lastname: Nishiwaki