title: A Call for Systematic Research on Solute Carriers.
abstract: Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.
authors.affiliation: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
authors.forename: Adrián
authors.initials: A
authors.lastname: César-Razquin
authors.affiliation: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
authors.forename: Berend
authors.initials: B
authors.lastname: Snijder
authors.affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
authors.forename: Tristan
authors.initials: T
authors.lastname: Frappier-Brinton
authors.affiliation: The Donnelly Centre, University of Toronto, Toronto, Ontario, M5S 3E1, Canada.
authors.forename: Ruth
authors.initials: R
authors.lastname: Isserlin
authors.affiliation: Institute of Biochemistry and Molecular Medicine and Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, 3012 Bern, Switzerland.
authors.forename: Gergely
authors.initials: G
authors.lastname: Gyimesi
authors.affiliation: Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8 Canada.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Bai
authors.affiliation: Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8 Canada.
authors.forename: Reinhart A
authors.initials: RA
authors.lastname: Reithmeier
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
authors.forename: David
authors.initials: D
authors.lastname: Hepworth
authors.affiliation: Institute of Biochemistry and Molecular Medicine and Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, 3012 Bern, Switzerland. Electronic address: matthias.hediger@ibmm.unibe.ch.
authors.forename: Matthias A
authors.initials: MA
authors.lastname: Hediger
authors.affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada. Electronic address: aled.edwards@utoronto.ca.
authors.forename: Aled M
authors.initials: AM
authors.lastname: Edwards
authors.affiliation: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address: gsuperti@cemm.oeaw.ac.at.
authors.forename: Giulio
authors.initials: G
authors.lastname: Superti-Furga
mesh_terms: D000818:Animals; D035843:Biomedical Research; D055808:Drug Discovery; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins