title: Combination of Juvenile Papillomatosis, Juvenile Fibroadenoma and Intraductal Carcinoma of the Breast in a 15-Year-old Girl.
abstract: The association of juvenile papillomatosis with carcinoma is proven, but very rare, as there exist several reported cases.
  
  
  METHODS
  A 15-year-old girl with no family history of breast cancer presented with two masses in the left breast. The excisional biopsy on both lumps revealed juvenile fibroadenoma and juvenile papillomatosis epithelial proliferation multiple cystic expanded channels. In some of these channels, cytological features of intraductal carcinoma were observed. We performed a full immunohistochemical examination of the juvenile papillomatosis. The patient refused any further surgical or adjuvant treatment. There are no signs of recurrence in the 15 year follow-up.
  
  
  CONCLUSIONS
  This case is a diagnostic and therapeutic challenge, taking into account the patient's age and the controversial treatment recommendations. Good collaboration between surgeons and pathologists is essential for an accurate diagnostic process and aims to avoid under- or overtreatment.
authors.affiliation: Department of Surgery, Queen Joanna University Hospital, Sofia, Bulgaria theosed@abv.bg.
authors.forename: Theophil
authors.initials: T
authors.lastname: Sedloev
authors.affiliation: Department of Pathology, Akerhus University Hospital, Oslo, Norway.
authors.forename: Assia
authors.initials: A
authors.lastname: Bassarova
authors.affiliation: Department of Surgery, Aleksandrovska University Hospital, Sofia, Bulgaria.
authors.forename: Kostadin
authors.initials: K
authors.lastname: Angelov
authors.affiliation: Department of Surgery, Aleksandrovska University Hospital, Sofia, Bulgaria.
authors.forename: Mariela
authors.initials: M
authors.lastname: Vasileva
authors.affiliation: Department of Surgery, Queen Joanna University Hospital, Sofia, Bulgaria.
authors.forename: Yavor
authors.initials: Y
authors.lastname: Asenov
mesh_terms: D000293:Adolescent; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D018226:Fibroadenoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D010212:Papilloma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
keywords: Intraductal carcinoma of the breast; case report; juvenile fibroadenoma; juvenile papillomathosis