title: Central nervous system imaging findings of hemophagocytic syndrome.
abstract: We present a rare case of intracranial involvement in hemophagocytic lymphohistiocytosis (HLH) in an adult patient. MRI features in HLH may mimic those of other neoplastic, infectious, or inflammatory disorders. Key imaging findings correlate to central nervous system inflammation and include diffuse leptomeningeal enhancement, white matter changes with variable enhancement, hemorrhage, and restricted diffusion. Recognition of the imaging characteristic in correlation with clinical presentation, laboratory values, and biopsy findings is essential for making a correct diagnosis.
authors.affiliation: Mayo Clinic Department of Radiology, Rochester MN 55905. Electronic address: Anderson.Tara@mayo.edu.
authors.forename: Tara L
authors.initials: TL
authors.lastname: Anderson
authors.affiliation: Mayo Clinic Department of Radiology, Rochester MN 55905. Electronic address: Carr.Carrie@mayo.edu.
authors.forename: Carrie M
authors.initials: CM
authors.lastname: Carr
authors.affiliation: Mayo Clinic Department of Radiology, Rochester MN 55905. Electronic address: Kaufmann.Timothy@mayo.edu.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Kaufmann
mesh_terms: D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008578:Meninges / Q000473:pathology*; D008875:Middle Aged
keywords: Central nervous system; Hemophagocytic lymphohistiocytosis; Inflammatory; MRI