title: Paclitaxel reduces formation of hypertrophic scars in the rabbit ear model.
abstract: OBJECTIVE
  The onset and progression of pathological scarring involves multiple cytokines and complex mechanisms. However, hyperplasia of fibroblasts and neovascularization plays important roles, which can be inhibited by paclitaxel. The aim of this study was to investigate the efficacy of paclitaxel in the treatment of hypertrophic scars on rabbit ears.
  
  
  METHODS
  Rabbit ear models of hypertrophic scars were established to observe the therapeutic effects of paclitaxel at different concentrations (12 mg/L, 24 mg/L, 48 mg/L, 96 mg/L, 18 mg/L, 54 mg/L, 162 mg/L, 486 mg/L, 30 mg/L, 150 mg/L, 750 mg/L, 3,750 mg/L). The outcome measures included hypertrophic index (HI), density of fibroblasts, density of collagenous fibers, and microvessel density.
  
  
  RESULTS
  In comparison with the control group, the concentrations of 96 mg/L, 150 mg/L, and 162 mg/L significantly reduce the formation of hypertrophic scars in the rabbit ear models. However, local necrosis was found in the rabbit ear models treated with paclitaxel solution >400 mg/L.
  
  
  CONCLUSIONS
  Paclitaxel has strong inhibitory effects on the hyperplasia of fibroblasts, deposition of collagen, and microangiogenesis in hypertrophic scars on rabbit ears within the concentration range from 48 mg/L to 162 mg/L, without causing local necrosis.
authors.affiliation: Department of Physical Therapy, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Huang
authors.affiliation: Department of Orthopedics, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Guo-Qi
authors.initials: GQ
authors.lastname: Wang
authors.affiliation: Department of Physical Therapy, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Zi-Shan
authors.initials: ZS
authors.lastname: Jia
authors.affiliation: Department of Physical Therapy, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Jing-Wen
authors.initials: JW
authors.lastname: Chen
authors.affiliation: Department of Physical Therapy, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Physical Therapy, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Xing-Lin
authors.initials: XL
authors.lastname: Wang
keywords: hypertrophic scar; paclitaxel; rabbit ear model