title: DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Nangalia
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors.forename: Francesca L
authors.initials: FL
authors.lastname: Nice
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
authors.forename: David C
authors.initials: DC
authors.lastname: Wedge
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Godfrey
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
authors.forename: Jacob
authors.initials: J
authors.lastname: Grinfeld
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Thakker
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors.forename: Charlie E
authors.initials: CE
authors.lastname: Massie
authors.affiliation: Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Cambridge Blood and Stem Cell Bank, University of Cambridge, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Baxter
authors.affiliation: Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Cambridge Blood and Stem Cell Bank, University of Cambridge, UK.
authors.forename: David
authors.initials: D
authors.lastname: Sewell
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Silber
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Campbell
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK arg1000@cam.ac.uk.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Green
mesh_terms: D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D005260:Female; D019337:Hematologic Neoplasms / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000201:enzymology / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics*
chemical_list: C000717967:DNMT3A protein, human; D009363:Neoplasm Proteins; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A
keywords: DNMT3A mutation; mutation order; myeloproliferative neoplasms