title: Gene expression profiling of hormonal regulation related to the residual feed intake of Holstein cattle.
abstract: An accumulation of over a decade of research in cattle has shown that genetic selection for decreased residual feed intake (RFI), defined as the difference between an animal's actual feed intake and its expected feed intake, is a viable option for improving feed efficiency and reducing the feed requirements of herds, thereby improving the profitability of cattle producers. Hormonal regulation is one of the most important factors in feed intake. To determine the relationship between hormones and feed efficiency, we performed gene expression profiling of jugular vein serum on hormonal regulation of Chinese Holstein cattle with low and high RFI coefficients. 857 differential expression genes (from 24683 genes) were found. Among these, 415 genes were up-regulated and 442 genes were down-regulated in the low RFI group. The gene ontology (GO) search revealed 6 significant terms and 64 genes associated with hormonal regulation, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) selected the adipocytokine signaling pathway, insulin signaling pathway. In conclusion, the study indicated that the molecular expression of genes associated with hormonal regulation differs in dairy cows, depending on their RFI coefficients, and that these differences may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.
authors.affiliation: Institute of Dairy Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Xi
authors.affiliation: Institute of Dairy Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Institute of Dairy Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: F
authors.initials: F
authors.lastname: Wu
authors.affiliation: Institute of Dairy Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China. Electronic address: zyhan6708@njau.edu.cn.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Han
authors.affiliation: Institute of Dairy Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China. Electronic address: glwang@njau.edu.cn.
authors.forename: G L
authors.initials: GL
authors.lastname: Wang
mesh_terms: D054392:Adipokines / Q000097:blood / Q000235:genetics*; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001069:Appetite Regulation / Q000235:genetics*; D001835:Body Weight / Q000235:genetics; D002417:Cattle; D003612:Dairying; D004435:Eating / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D007328:Insulin / Q000097:blood / Q000235:genetics*; D020738:Leptin / Q000097:blood / Q000235:genetics*; D058977:Molecular Sequence Annotation; D009478:Neuropeptide Y / Q000097:blood / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D054392:Adipokines; D007328:Insulin; D020738:Leptin; D009478:Neuropeptide Y
keywords: Dairy cow; Gene expression profiling; Leptin-NPY/insulin signaling pathway; Residual feed intake