title: [Radiosynthesis and preliminary evaluation of 5-([11C]methyloxy)-L-tryptophan as PET tumor imaging].
abstract: The PET tracer 5-([11C]methyloxy)-L-tryptophan (5-(11)CMTP) was prepared by nucleophilic fluorination and alkylation reaction via a two-step procedure in order to develop specific tumor probe. The biodistribution and microPET imaging of 5-(11)CMTP were executed. The results unveiled that the overall radiochemical yield with no decay correction was (14.6 ±7.2) %, the radiochemical purity was more than 95% and high uptake and long retention time of 5-(11)CMTP in liver, kidney and blood were observed but low uptake in brain and muscle were found, furthermore, high uptake of 5-(11)CMTP in tumor tissue was observed. It seems that 5-(11)CMTP will be a potential amino acid tracer for tumors imaging with PET.
authors.forename: Shan-zhen
authors.initials: SZ
authors.lastname: He
authors.forename: Shu-xia
authors.initials: SX
authors.lastname: Wang
authors.forename: Kong-zhen
authors.initials: KZ
authors.lastname: Hu
authors.forename: Bao-guo
authors.initials: BG
authors.lastname: Yao
authors.forename: Gang-hua
authors.initials: GH
authors.lastname: Tang
mesh_terms: D000596:Amino Acids; D000818:Animals; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D011849:Radioactive Tracers; D014018:Tissue Distribution; D014364:Tryptophan / Q000031:analogs & derivatives
chemical_list: D000596:Amino Acids; D011849:Radioactive Tracers; D014364:Tryptophan