title: Potential prognostic significance of a new proteomic profile in patients with advanced pancreatic adenocarcinoma.
abstract: OBJECTIVE
  Seven-signal proteomic approach has recently been developed as a new proteomic profile measured by matrix-assisted laser desorption/ionization mass spectrometry. The aim of this study was to evaluate prognostic significance of this proteomic value in patients with pancreatic adenocarcinoma.
  
  
  METHODS
  Blood samples from the patients with pancreatic adenocarcinoma were prospectively collected before treatments including surgical resection and systemic chemotherapies. The seven-signal proteomic profiles of the samples were measured, and the prognostic significance of the proteomic value was evaluated through comparison with other existing prognostic markers.
  
  
  RESULTS
  Cut-off value of the proteomic profiles at 52 stratified overall prognosis of the patients (6.5 months vs. 10.9 months with the values ≥52 vs. <52, p = 0.020). In subgroup analyses of inoperable cases with carcinoembryonic antigen level of <5 ng/ml or performance status of 0-1, the proteomic value at 52 stratified their prognosis (p = 0.002 and p = 0.006, respectively).
  
  
  CONCLUSIONS
  The new seven-signal proteomics showed useful prognostic significance for patients with pancreatic adenocarcinoma. Further studies with a large sample size would be required to evaluate whether this proteomic approach possibly complements the existing parameters, such as carcinoembryonic antigen and performance status.
authors.affiliation: Division of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Japan. Electronic address: kobayashis@kcch.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Division of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ueno
authors.affiliation: Division of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Japan.
authors.forename: Kuniyasu
authors.initials: K
authors.lastname: Irie
authors.affiliation: Division of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Goda
authors.affiliation: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Aoyama
authors.affiliation: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Morinaga
authors.affiliation: Division of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ohkawa
authors.affiliation: Division of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Morimoto
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D020543:Proteome
keywords: Carbohydrate antigen 19-9; Carcinoembryonic antigen; Prognosis; Prognostic factor; Proteomics; Tumor marker