title: Invertebrates as model organisms for research on aging biology.
abstract: Invertebrate model systems, such as nematodes and fruit flies, have provided valuable information about the genetics and cellular biology involved in aging. However, limitations of these simple, genetically tractable organisms suggest the need for other model systems, some of them invertebrate, to facilitate further advances in the understanding of mechanisms of aging and longevity in mammals, including humans. This paper introduces 10 review articles about the use of invertebrate model systems for the study of aging by authors who participated in an 'NIA-NIH symposium on aging in invertebrate model systems' at the 2013 International Congress for Invertebrate Reproduction and Development. In contrast to the highly derived characteristics of nematodes and fruit flies as members of the superphylum Ecdysozoa, cnidarians, such asHydra,are more 'basal' organisms that have a greater number of genetic orthologs in common with humans. Moreover, some other new model systems, such as the urochordateBotryllus schlosseri, the tunicateCiona, and the sea urchins (Echinodermata) are members of the Deuterostomia, the same superphylum that includes all vertebrates, and thus have mechanisms that are likely to be more closely related to those occurring in humans. Additional characteristics of these new model systems, such as the recent development of new molecular and genetic tools and a more similar pattern to humans of regeneration and stem cell function suggest that these new model systems may have unique advantages for the study of mechanisms of aging and longevity.
authors.affiliation: Division of Aging Biology, National Institute on Aging, National Institutes of Health , Bethesda , MD 20892 , USA.
authors.forename: Mahadev
authors.initials: M
authors.lastname: Murthy
authors.affiliation: Department of Physiology, Wayne State University , Detroit , MI 48201 , USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Ram