title: Caffeine and modafinil given during 48 h sleep deprivation modulate object recognition memory and synaptic proteins in the hippocampus of the rat.
abstract: We aimed to evaluate the effect of caffeine/modafinil on sleep deprivation (SD) induced alterations in recognition memory and synaptic proteins. The data revealed a beneficial effect of caffeine/modafinil against deficit in the familiar object retrieval performance and object exploration ratio after 48 h SD. Caffeine treatment prevented the SD induced down-regulation of synaptophysin and synapsin I proteins with no change in PSD-95 protein in hippocampus. However, modafinil administration improved the down-regulation of synaptophysin, synapsin I and PSD-95 proteins in hippocampus. Hence, caffeine/modafinil can serve as counter measures in amelioration of SD induced consequences at behavioural and protein levels.
authors.affiliation: Department of Neurophysiology, Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Wadhwa
authors.affiliation: Department of Neurophysiology, Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Sahu
authors.affiliation: Department of Neurophysiology, Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi, India.
authors.forename: P
authors.initials: P
authors.lastname: Kumari
authors.affiliation: Department of Neurophysiology, Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi, India.
authors.forename: H
authors.initials: H
authors.lastname: Kauser
authors.affiliation: Department of Neurophysiology, Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi, India.
authors.forename: K
authors.initials: K
authors.lastname: Ray
authors.affiliation: Department of Neurophysiology, Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi, India. Electronic address: neurophysiolab.dipas@gmail.com.
authors.forename: U
authors.initials: U
authors.lastname: Panjwani
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D004195:Disease Models, Animal; D000076122:Disks Large Homolog 4 Protein; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D000077408:Modafinil; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D021641:Recognition, Psychology / Q000187:drug effects* / Q000502:physiology; D012892:Sleep Deprivation / Q000188:drug therapy* / Q000378:metabolism; D013569:Synapses / Q000187:drug effects / Q000378:metabolism; D016704:Synapsins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism; D013997:Time Factors; D064690:Wakefulness-Promoting Agents / Q000494:pharmacology*
chemical_list: D001559:Benzhydryl Compounds; D000076122:Disks Large Homolog 4 Protein; C501449:Dlg4 protein, rat; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D016704:Synapsins; D016708:Synaptophysin; D064690:Wakefulness-Promoting Agents; D002110:Caffeine; D000077408:Modafinil
keywords: Caffeine; Modafinil; Novel object recognition memory; Sleep deprivation; Synaptic protein