title: Total Synthesis of Clavosolide A via Tandem Allylic Oxidation/Oxa-Conjugate Addition Reaction.
abstract: The tandem allylic oxidation/oxa-conjugate addition reaction promoted by thegem-disubstituent effect in conjunction with the NHC-mediated oxidative esterification was explored for the facile synthesis of clavosolide A.
authors.affiliation: Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Baker
authors.affiliation: College of Pharmacy, Ajou University, Suwon 443-749, South Korea.
authors.forename: Hyoungsu
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
authors.forename: Jiyong
authors.initials: J
authors.lastname: Hong
keywords: clavosolide; gem-disubstituent effect; natural product; oxa-conjugate addition; tandem reaction; tetrahydropyran; total synthesis