title: Association between genetic polymorphisms in cortactin and susceptibility to gastric cancer.
abstract: OBJECTIVE
  Overexpression of cortactin (CTTN) in human tumors has been proposed to result in increased cell migration and metastatic potential. Here, we determined the frequencies of CTTN g.-9101C>T, g.-8748C>T, and g.72C>T polymorphisms in apparently healthy subjects and gastric cancer patients, respectively, and the influence of the CTTN polymorphisms on gastric cancer susceptibility.
  
  
  METHODS
  Blood samples were collected from 267 patients and 533 controls. CTTN g.-8748C>T and g.-9101C>T polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism; the g.72C>T polymorphism was determined using the TaqMan method.
  
  
  RESULTS
  Genotype frequencies of the CTTN g.-9101C>T polymorphism were 97.5% (TT), 2.5% (TC), and 0% (CC) in the patient group, and 98.6% (TT), 1.4% (TC), and 0% (CC) in the control group. Genotype frequencies of the CTTN g.-8748C>T polymorphism were 93.3% (TT), 6.8% (TC), and 0% (CC) in the patient group, and 94.2% (TT), 5.8% (TC), and 0% (CC) in the control group. Genotype frequencies of the CTTN g.72C>T polymorphism were 82.4% (CC), 17.2% (CT), and 0.4% (TT) in the patient group, and 78.0% (CC), 20.1% (CT), and 1.9% (TT) in the control group. Genotype and allele frequencies of the CTTN g.-9101C>T polymorphism differed significantly between the advanced gastric cancer and control groups. Patients with advanced gastric cancer, possessing the TC genotype, had a significantly poorer prognosis than the group with the TT genotype.
  
  
  CONCLUSIONS
  The CTTN g.-9101C>T polymorphism might influence advanced gastric cancer susceptibility. However, the role of the CTTN g.-9101C>T, g.-8748C>T, and g.72C>T polymorphisms requires careful interpretation and confirmation through larger studies.
authors.affiliation: Department of Surgery, Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Dae Yong
authors.initials: DY
authors.lastname: Kim
authors.affiliation: Department of Surgery, Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Surgery, Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Keun Young
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Department of Surgery, Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Dong Baek
authors.initials: DB
authors.lastname: Kang
authors.affiliation: Department of Surgery, Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Won Cheol
authors.initials: WC
authors.lastname: Park
authors.affiliation: Department of Pathology, Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Soo Cheon
authors.initials: SC
authors.lastname: Chae
authors.affiliation: Department of Surgery, Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Jeong Kyun
authors.initials: JK
authors.lastname: Lee
keywords: Genetic polymorphism; Human CTTN protein; Stomach neoplasms