title: The evolving role of dabigatran etexilate in clinical practice.
abstract: BACKGROUND
  Stroke and venous thromboembolism (VTE) affect millions of patients. The vitamin K antagonist, warfarin, has been the main oral anticoagulant used to treat these conditions despite many limitations associated with its use. Recently, multiple novel oral anticoagulants have been approved and are reshaping how patients with atrial fibrillation (AF) at risk of stroke and patients with VTE are treated. The direct thrombin inhibitor, dabigatran etexilate , is among these novel agents that have been developed to overcome limitations with warfarin.
  
  
  METHODS
  In this article, authors describe the pharmacokinetic and pharmacodynamic properties of dabigatran etexilate and summarize the clinical evidence and controversy surrounding its use in the US, Canada and Europe.
  
  
  CONCLUSIONS
  Dabigatran has demonstrated similar efficacy and safety to enoxaparin for VTE prevention in patients undergoing hip and knee arthroplasty, and to warfarin for the treatment of VTE. Dabigatran (110 mg) is noninferior and dabigatran (150 mg) is superior to warfarin for stroke prevention in patients with nonvalvular AF, with a lower rate of intracranial hemorrhage reported at both doses. Apixaban, rivaroxaban and edoxaban provide alternate anticoagulant options to dabigatran. While there are many similarities, there are also significant differences to consider in agent selection based on patient-specific characteristics.
authors.affiliation: University of Illinois at Chicago College of Pharmacy , 833 South Wood Street, Suite 164, MC 886, Chicago, IL 60612 , USA.
authors.forename: Erika
authors.initials: E
authors.lastname: Hellenbart
authors.forename: Beatrice
authors.initials: B
authors.lastname: Drambarean
authors.forename: James
authors.initials: J
authors.lastname: Lee
authors.forename: Edith A
authors.initials: EA
authors.lastname: Nutescu
mesh_terms: D000991:Antithrombins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee; D001281:Atrial Fibrillation / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002986:Clinical Trials as Topic; D000069604:Dabigatran / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017984:Enoxaparin / Q000627:therapeutic use; D006801:Humans; D011720:Pyrazoles / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D011728:Pyridones / Q000627:therapeutic use; D000069552:Rivaroxaban / Q000627:therapeutic use; D020521:Stroke / Q000517:prevention & control; D013844:Thiazoles / Q000627:therapeutic use; D054556:Venous Thromboembolism / Q000188:drug therapy
chemical_list: D000991:Antithrombins; D017984:Enoxaparin; D011720:Pyrazoles; D011725:Pyridines; D011728:Pyridones; D013844:Thiazoles; C522181:apixaban; D000069552:Rivaroxaban; D000069604:Dabigatran; C552171:edoxaban
keywords: anticoagulation; atrial fibrillation; dabigatran etexilate; direct thrombin inhibitors; oral anticoagulants; venous thromboembolism