title: [Serum Clara cell 16-kDa protein (CC16) levels and lung impairment in systemic sclerosis patients].
abstract: OBJECTIVE
  To assess clinical utility of serum Clara cell 16-kDa protein (CC16) measurements in relation with staging system for systemic sclerosis associated interstitial lung disease (SSc-ILD).
  
  
  METHODS
  Serum levels of CC16 were determined by ELISA in 28 SSc patients and 30 healthy controls, and correlated with staging system for SSc-ILD in SSc patients. Lung involvement was assessed functionally (body plethysmography, diffusing capacity of the lung for carbon monoxide) and radiologically (an average disease extent on high resolution computed tomography of the lungs, HRCT) in SSc patients.
  
  
  RESULTS
  We observed statistically significant differences in serum CC16 levels between SSc patients and healthy controls only in non-smokers. However, serum CC16 concentrations were significantly elevated in patients with HRCT extent>20% in comparison to patients with HRCT extent<20% (p=0.01). They correlated positively with average disease extent on HRCT (p=0.04), an extent of a reticular pattern on HRCT (p<0.01), and negatively with a total lung capacity (TLC) (p=0.03) and the results of the 6-min walk test (p<0.01).
  
  
  CONCLUSIONS
  CC16 levels can be considered as a supplemental serum biomarker for SSc-ILD.
authors.affiliation: Departamento de Reumatologia e Imunologia Clínica, Universidade de Ciências Médicas Poznan, Poznan, Polônia. Electronic address: anolegaw@wp.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Olewicz-Gawlik
authors.affiliation: Departamento de Reumatologia e Imunologia Clínica, Universidade de Ciências Médicas Poznan, Poznan, Polônia.
authors.forename: Dorota
authors.initials: D
authors.lastname: Trzybulska
authors.affiliation: Departamento de Pneumologia, Alergologia e Pneumologia Oncológica, Universidade de Ciências Médicas Poznan, Poznan, Polônia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kuznar-Kaminska
authors.affiliation: Departamento de Radiologia Geral e Neurorradiologia, Universidade de Ciências Médicas Poznan, Poznan, Polônia.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Katulska
authors.affiliation: Departamento de Dermatologia, Universidade de Ciências Médicas Poznan, Poznan, Polônia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Danczak-Pazdrowska
authors.affiliation: Departamento de Pneumologia, Alergologia e Pneumologia Oncológica, Universidade de Ciências Médicas Poznan, Poznan, Polônia.
authors.forename: Halina
authors.initials: H
authors.lastname: Batura-Gabryel
authors.affiliation: Departamento de Reumatologia e Imunologia Clínica, Universidade de Ciências Médicas Poznan, Poznan, Polônia.
authors.forename: Pawel
authors.initials: P
authors.lastname: Hrycaj
keywords: CC16; Doença intersticial pulmonar; Esclerose sistêmica; Interstitial lung disease; Systemic sclerosis