title: Association between TNF-α (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study is to investigate whether TNF-α polymorphisms are associated with the responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease.
  
  
  METHODS
  We conducted a meta-analysis on the association between the TNF-α polymorphisms and responsiveness of patients.
  
  
  RESULTS
  The meta-analysis indicated an association between the TNF-α -308 G allele (OR = 2.005; 95% CI: 1.417-2.838; p = 8.6 × 10(-5)), TNF-α -238 G allele (OR = 2.196; 95% CI: 1161-4.154; p = 0.016), and TNF-α -857 C allele (OR = 1.779; 95% CI: 1.130-2.802; p = 0.013) and response to TNF-α blockers in Caucasians.
  
  
  CONCLUSIONS
  Individuals carrying the TNF-α -308 G, -238 G, or -857 C common alleles show better responses to TNF-α blockers than those with minor alleles in Caucasians.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Seo
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Choi
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Jong Dae
authors.initials: JD
authors.lastname: Ji
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D000483:Alleles; D003424:Crohn Disease / Q000188:drug therapy / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics*; D025242:Spondylarthropathies / Q000188:drug therapy / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: TNF-α inhibitors; TNF-α polymorphism; psoriasis; responsiveness; spondyloarthropathy