title: Association of Endothelial and Mild Renal Dysfunction With the Severity of Left Ventricular Hypertrophy in Hypertensive Patients.
abstract: BACKGROUND
  The association between impaired renal function and increase left ventricular mass was shown to be related to increase in arterial stiffness, which indicates that vascular homeostasis and remodeling may impact the left ventricular hypertrophy (LVH) in patients with renal dysfunction.
  
  
  METHODS
  We measured the peripheral arterial reactive hyperemia index (RHI) and estimated glomerular filtration rate (eGFR) in 317 hypertensive patients comprising 115 normal RHI (RHI > 1.67) and normal eGFR (eGFR ≥ 90ml/min per 1.73 m(2)), 136 low RHI (RHI ≤ 1.67), 27 low eGFR (60 ≤ eGFR < 90ml/min per 1.73 m(2)) and 39 low RHI combined with low eGFR.
  
  
  RESULTS
  Multivariate logistic regression analysis identified lg RHI (odds ratio (OR): 0.001, 95% confidence interval (CI): 10(-6) to 0.426, P = 0.024) and lg eGFR (OR: 0.009, 95% CI: 10(-4) to 0.414, P = 0.016) as independent factors correlated with LVH respectively in hypertensive patients. Compared with normal RHI and eGFR patients, the extent of LVH in patients with either low RHI (OR: 1.224 95% CI: 0.451 to 3.327, P = 0.691) or low eGFR (OR: 0.593 95% CI: 0.070 to 5.037, P = 0.632) did not significantly increase, while it increased significantly in patients with low RHI combined with low eGFR (OR: 4.629 95% CI: 1.592 to 13.458, P = 0.005).
  
  
  CONCLUSIONS
  The concurrence of endothelial and mild renal dysfunction was significantly associated with the severity of LVH in hypertensive patients.
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Cheng
authors.initials: C
authors.lastname: Cao
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Hu
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China; Key Laboratory of Molecular Biology in Jiangxi Province, Nanchang City, Jiangxi Province, China. yf_dong66@126.com.
authors.forename: Yi-Fei
authors.initials: YF
authors.lastname: Dong
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Rui
authors.initials: R
authors.lastname: Zhan
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Hai
authors.initials: H
authors.lastname: Su
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Qiang
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Xiao
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Sun
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Wu
authors.affiliation: Department of Cardiovascular Medicine, Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, China;
authors.forename: Xiao-Shu
authors.initials: XS
authors.lastname: Cheng
mesh_terms: D000368:Aged; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D066253:Vascular Remodeling; D059289:Vascular Stiffness
keywords: blood pressure; endothelial dysfunction; hypertension; left ventricular hypertrophy; renal dysfunction.