title: No Detrimental Effect of a Positive Family History on Long-Term Outcomes Following Radical Prostatectomy.
abstract: OBJECTIVE
  Overall 1 in 5 patients with prostate cancer has a positive family history. In this report we evaluated the association between family history and long-term outcomes following radical prostatectomy.
  
  
  METHODS
  Patients treated with radical prostatectomy were identified from a German registry, and separated into positive first-degree family history vs negative family history (strictly negative, requiring at least 1 male first-degree relative older than 60 years and no prostate cancer in the family). Kaplan-Meier curves and Cox proportional hazards models were used for association analyses with biochemical recurrence-free and prostate cancer specific survival.
  
  
  RESULTS
  Median followup for 7,690 men included in the study was 8.4 years. Of the 754 younger patients less than 55 years old 50.9% (384) had a family history compared to 40.4% of the older patients (2,803; p <0.001). The 10-year biochemical recurrence-free (62.5%) and prostate cancer specific survival (96.1%) rates did not differ between patients with vs without a family history, nor between the younger vs older patient groups (all p >0.05). Prostate specific antigen, pathological stage, node stage and Gleason score were the only significant predictors for biochemical recurrence-free survival, while pathological stage, node stage (all p <0.005) and Gleason score (Gleason 7 vs 6 or less-HR 1.711, 95% CI 1.056-2.774, p = 0.03; Gleason 8 or greater vs 6 or less-HR 4.516, 95% CI 2.776-7.347, p <0.0001) were the only predictors for prostate cancer specific survival.
  
  
  CONCLUSIONS
  A family history of prostate cancer has no bearing on long-term outcomes after radical prostatectomy.
authors.affiliation: Department of Urology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany.
authors.forename: Johannes M S
authors.initials: JM
authors.lastname: Brath
authors.affiliation: Departments of Life Sciences and Mathematics, Technische Universitaet Muenchen, Munich, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Grill
authors.affiliation: Departments of Life Sciences and Mathematics, Technische Universitaet Muenchen, Munich, Germany.
authors.forename: Donna P
authors.initials: DP
authors.lastname: Ankerst
authors.affiliation: Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
authors.forename: Ian M
authors.initials: IM
authors.lastname: Thompson
authors.affiliation: Department of Urology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany.
authors.forename: Juergen E
authors.initials: JE
authors.lastname: Gschwend
authors.affiliation: Department of Urology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany. Electronic address: kathleen.herkommer@tum.de.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Herkommer
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005858:Germany; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D012042:Registries; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: age factors; family; prostatectomy; prostatic neoplasms; survival rate