title: Critical Assessment of Endoscopic Techniques for Gastroesophageal Reflux Disease.
abstract: Over the past 2 decades, a number of new endoscopic techniques have been developed for management of gastroesophageal (GE) reflux disease symptoms as alternatives to medical management and surgical fundoplication. These devices include application of radiofrequency treatment (Stretta), endoscopic plication (EndoCinch, Plicator, Esophyx, MUSE), and injection of bulking agents (Enteryx, Gatekeeper, Plexiglas, Duragel). Their goal was symptom relief through reduction of tissue compliance and enhancement of anatomic resistance at the GE junction. In this review, we critically assess the research behind the efficacy, safety, and durability of these treatments to better understand their roles in contemporary GE reflux disease management.
authors.affiliation: *Department of Gastroenterology, VA Boston Healthcare System †Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital ‡Harvard Medical School, Boston, MA.
authors.forename: Wai-Kit
authors.initials: WK
authors.lastname: Lo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mashimo
mesh_terms: D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects / Q000379:methods*; D004943:Esophagogastric Junction / Q000378:metabolism; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000628:therapy*; D006801:Humans