title: Long-Term Prostaglandin E1 Infusion for Newborns with Critical Congenital Heart Disease.
abstract: Prostaglandin E1 is crucial for keeping the patent ductus arteriosus in critical congenital heart disease for the survival and palliation of particularly prematurely born babies until a cardiosurgical intervention is available. In this study, the side effects of prostaglandin E1 in newborns with critical congenital heart disease and clinical outcomes were evaluated. Thirty-five newborns diagnosed with critical congenital heart disease were treated with prostaglandin E1 between January 2012 and September 2014 at our hospital. Patient charts were examined for prostaglandin E1 side effects (metabolic, gastric outlet obstruction, apnea), clinical status, and prognosis. Acquired data were analyzed in the SPSS 20.0 program. Patients with birth weight under 2500 g needed more days of prostaglandin E1 infusion than ones with birthweight over 2500 g (P = 0.016). The ratio of patients with birth weight under 2500 g who received prostaglandin E1 longer than 7 days was higher than the patients with birth weight over 2500 g (P = 0.02). Eighteen side effects were encountered in 11 of 35 patients (31%). Of these side effects, 1 patient had 4, 4 patients had 2, and 6 patients had only 1 side effect. Discontinuation of the therapy was never needed. Prostaglandin E1 is an accepted therapy modality for survival and outcome in critical congenital heart disease in particularly low-birth-weight babies until a surgical intervention is available. Side effects are not less encountered but are almost always manageable, and discontinuation is not needed.
authors.affiliation: Department of Pediatrics, Zeynep Kamil Maternity and Children's Training and Research Hospital, Uskudar, Istanbul, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Aykanat
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Training and Research Hospital, Uskudar, Istanbul, Turkey. taneryavuz@yahoo.com.
authors.forename: Taner
authors.initials: T
authors.lastname: Yavuz
authors.affiliation: Division of Neonatology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Training and Research Hospital, Uskudar, Istanbul, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Özalkaya
authors.affiliation: Division of Neonatology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Training and Research Hospital, Uskudar, Istanbul, Turkey.
authors.forename: Sevilay
authors.initials: S
authors.lastname: Topçuoğlu
authors.affiliation: Division of Neonatology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Training and Research Hospital, Uskudar, Istanbul, Turkey.
authors.forename: Fahri
authors.initials: F
authors.lastname: Ovalı
authors.affiliation: Division of Neonatology, Department of Pediatrics, Zeynep Kamil Maternity and Children's Training and Research Hospital, Uskudar, Istanbul, Turkey.
authors.forename: Güner
authors.initials: G
authors.lastname: Karatekin
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects; D001724:Birth Weight; D005260:Female; D006330:Heart Defects, Congenital / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D010166:Palliative Care; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
chemical_list: D010975:Platelet Aggregation Inhibitors; D000527:Alprostadil
keywords: Critical congenital heart disease; Newborn; Prostaglandin E1