title: Cytochrome P450-CYP2 Family-Epoxygenase Role in Inflammation and Cancer.
abstract: Arachidonic acids are converted to eicosanoid mediators by different enzyme systems: cyclooxygenase, lipoxygenase, and cytochrome P450 (CYP) monooxygenase pathways (ω/ω-1-hydroxylases and epoxygenases). Of 57 putatively functional human CYPs, only about a dozen enzymes are responsible for xenobiotic metabolism. CYP2 family is the predominant epoxygenase isoform abundantly expressed in the endothelium, myocardium, and kidney in humans. Numerous studies have demonstrated the cardiovascular protective effects of CYP epoxygenases and eicosatrienoic acids ranging from vasodilation, antihypertensive, proangiogenesis, antiatherosclerosis, and cardiac protection. The roles of CYP2 family and their metabolites in inflammation and cancer biology have recently attracted great attention. Here, we review the recent progress on polymorphisms, distribution and function of CYP2 family, and their roles in inflammation and cancer.
authors.affiliation: Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. Electronic address: dwwang@tjh.tjmu.edu.cn.
authors.forename: Dao Wen
authors.initials: DW
authors.lastname: Wang
mesh_terms: D016718:Arachidonic Acid / Q000378:metabolism; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D016718:Arachidonic Acid; D003577:Cytochrome P-450 Enzyme System; D000090762:Cytochrome P-450 CYP2J2
keywords: Arachidonic acids; CYP2; Cancer; Cytochrome P450; Inflammation