title: Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies.
abstract: Novel, quinolone-fluoroquinolone conjugates 10a-f, 11a-f, 13a-f and 14a-f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA; Department of Chemistry & Physics, Georgia Reagents University, Augusta, GA 30912, USA. Electronic address: sspanda12@gmail.com.
authors.forename: Siva S
authors.initials: SS
authors.lastname: Panda
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA; Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
authors.forename: Sumaira
authors.initials: S
authors.lastname: Liaqat
authors.affiliation: Pesticide Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
authors.forename: Adel S
authors.initials: AS
authors.lastname: Girgis
authors.affiliation: Microbiology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Samir
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
authors.forename: C Dennis
authors.initials: CD
authors.lastname: Hall
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones
keywords: Amino acids; Anti-bacterial; Conjugates; Fluoroquinolone; QSAR; Quinolone