title: Role of Environmental Chemical Insult in Neuronal Cell Death and Cytoskeleton Damage.
abstract: Environmental influences, such as chemical exposure, have long been considered potential risk factors for neurodegenerative disorders, including neuromuscular diseases. However, no definitive links between environmental chemical exposure and a pathogenic mechanism of neurodegenerative disease has yet been established. In this study, we describe that exposure to arsenic, an environmental pollutant naturally found in drinking water, induces neuronal cell death and alteration of morphology, particularly neurite outgrowth and in the cytoskeleton of neurons. Since progressive cell loss accompanied by the alteration of neuronal structures and cytoskeleton is considered the major pathologic feature of neurodegenerative disorders, arsenic-induced neurotoxicity might contribute to an etiologic mechanism of some neurodegenerative diseases. Further, we discuss the importance of in vitro assay, particularly an embryonic toxicity test, for assessing the neurotoxicity of chemicals, because most of chemicals found in our environment remain to be evaluated regarding their neurotoxicity risk for neurodegenerative diseases.
authors.affiliation: Department of Pharmacology, National Research Institute for Child Health and Development.
authors.forename: Kyaw Htet
authors.initials: KH
authors.lastname: Aung
authors.forename: Shinji
authors.initials: S
authors.lastname: Tsukahara
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Maekawa
authors.forename: Keiko
authors.initials: K
authors.lastname: Nohara
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Nakamura
authors.forename: Akito
authors.initials: A
authors.lastname: Tanoue
mesh_terms: D000818:Animals; D001151:Arsenic / Q000009:adverse effects*; D016923:Cell Death; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000473:pathology*; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D016501:Neurites; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D020258:Neurotoxicity Syndromes / Q000150:complications*
chemical_list: D004785:Environmental Pollutants; D001151:Arsenic