title: HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity.
abstract: This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia.
authors.affiliation: Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III, Majadahonda, Madrid 28220, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Pernas
authors.affiliation: AIDS Research Unit, Institut d´Investigacions Biomediquès August Pi i Sunyer, Barcelona, Spain; HIVACAT, Barcelona, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: Sanchez-Merino
authors.affiliation: Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III, Majadahonda, Madrid 28220, Spain.
authors.forename: Concepcion
authors.initials: C
authors.lastname: Casado
authors.affiliation: AIDS Research Unit, Institut d´Investigacions Biomediquès August Pi i Sunyer, Barcelona, Spain; HIVACAT, Barcelona, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Merino-Mansilla
authors.affiliation: Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III, Majadahonda, Madrid 28220, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Olivares
authors.affiliation: AIDS Research Unit, Institut d´Investigacions Biomediquès August Pi i Sunyer, Barcelona, Spain; HIVACAT, Barcelona, Spain.
authors.forename: Eloisa
authors.initials: E
authors.lastname: Yuste
authors.affiliation: Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III, Majadahonda, Madrid 28220, Spain.
authors.forename: Cecilio
authors.initials: C
authors.lastname: Lopez-Galindez
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D019277:Entropy; D005500:Follow-Up Studies; D014644:Genetic Variation; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000145:classification* / Q000276:immunology; D006801:Humans; D009500:Neutralization Tests; D010802:Phylogeny; D019562:Viral Load; D014766:Viremia / Q000821:virology*
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies