title: Preparation of Information-Containing Macromolecules by Ligation of Dyad-Encoded Oligomers.
abstract: A simplified strategy for preparing non-natural information-containing polymers is reported. The concept relies on the successive ligation of oligomers that contain minimal sequence motifs. It was applied here to the synthesis of digitally-encoded poly(triazole amide)s, in which propyl and 2-methyl propyl motifs are used to code 0 and 1, respectively. A library of four oligo(triazole amide)s containing the information dyads 00, 01, 10, and 11 was prepared. These oligomers contain two reactive functions, that is, an alkyne and a carboxylic acid. Thus, they can be linked to another with the help of a reactive spacer containing azide and amine functions. Using two successive chemoselective steps, that is, azide-alkyne Huisgen cycloaddition and carboxylic acid-amine coupling, monodisperse polymers can be obtained. In particular, the library of dyads permits the implementation of any desired sequence using a small number of steps. As a proof-of-concept, the synthesis of molecular bytes 00000000 and 00000110 is described.
authors.affiliation: Precision Macromolecular Chemistry, Institut Charles Sadron, UPR-22 CNRS, 23 rue du Loess, 67034 Strasbourg (France).
authors.forename: Thanh Tam
authors.initials: TT
authors.lastname: Trinh
authors.affiliation: Precision Macromolecular Chemistry, Institut Charles Sadron, UPR-22 CNRS, 23 rue du Loess, 67034 Strasbourg (France).
authors.forename: Laurence
authors.initials: L
authors.lastname: Oswald
authors.affiliation: Precision Macromolecular Chemistry, Institut Charles Sadron, UPR-22 CNRS, 23 rue du Loess, 67034 Strasbourg (France).
authors.forename: Delphine
authors.initials: D
authors.lastname: Chan-Seng
authors.affiliation: Aix-Marseille Université- CNRS, Institute of Radical Chemistry, UMR 7273, Avenue Escadrille Normandie-Niemen, 13397 Marseille (France).
authors.forename: Laurence
authors.initials: L
authors.lastname: Charles
authors.affiliation: Precision Macromolecular Chemistry, Institut Charles Sadron, UPR-22 CNRS, 23 rue du Loess, 67034 Strasbourg (France). jflutz@unistra.fr.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Lutz
keywords: convergent synthesis; information-containing macromolecules; iterative chemistry; sequence-controlled polymers; soluble supports