title: The utility of urine sulphosalicylic acid testing in the detection of non-albumin proteinuria.
abstract: We report two cases of immunoglobulin light chain proteinuria (Bence Jones proteinuria) detected by simple side-room invest-igations: urine dipstick negative/1+, but with strong positive pre-cipitation on addition of an equal volume of sulphosalicylic acid (SSA) 3%. We highlight a significant limitation of urine dipstick testing, namely specificity for albumin, and the utility of SSA testing for the detection of urinary free light chain immunoglobulins.
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Faculty of Health Sciences, University of Cape Town, and Renal Unit, Livingstone Hospital, Port Elizabeth, South Africa. robert.freercks@uct.ac.za.
authors.forename: S
authors.initials: S
authors.lastname: Ndamase
authors.forename: R
authors.initials: R
authors.lastname: Freercks
mesh_terms: D000418:Albumins; D001557:Benzenesulfonates / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000175:diagnosis* / Q000652:urine; D012459:Salicylates / Q000652:urine*; D016482:Urinalysis / Q000379:methods*
chemical_list: D000418:Albumins; D001557:Benzenesulfonates; D015415:Biomarkers; D012459:Salicylates; C003366:sulfosalicylic acid