title: Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid vs. carbon dioxide laser in treatment of xanthelasma palpebrarum.
abstract: BACKGROUND
  There are numerous methods currently available for the management of xanthelasma. These include surgical excision, laser ablation using a variety of lasers and chemical cauterization. However, each method of treatment is associated with particular limitations and side effects.
  
  
  OBJECTIVE
  To assess the clinical efficacy and tolerability of different concentrations of topical trichloroacetic acid (TCA) vs. carbon dioxide laser in the treatment of patients with xanthelasma palpebrarum.
  
  
  METHODS
  Thirty patients with xanthelasma palpebrarum were classified into four groups, treated by TCA 35%, 50%, 70%, and CO2 laser, respectively. Lipid profile was estimated for all patients.
  
  
  RESULTS
  Both TCA peeling 70% and carbon dioxide laser ablation showed more significant clinical efficacy and tolerability with least number of sessions in the treatment of xanthelasma palpebrarum than 50% and 35% TCA peeling. Post-therapy erythema and hypopigmentation were more with TCA 70%. Post-therapy hyperpigmentation was more with TCA (50%). There was a significant improvement in patients with normal lipid profile than those with abnormal profile.
  
  
  CONCLUSIONS
  Both TCA peeling 70% and carbon dioxide laser ablation are highly effective and well tolerated with least number of sessions in the treatment of xanthelasma palpebrarum.
authors.affiliation: Department of Dermatology & Venereology, Faculty of medicine, Tanta University, Tanta, Egypt.
authors.forename: Basma
authors.initials: B
authors.lastname: Mourad
authors.affiliation: Department of Dermatology & Venereology, Faculty of medicine, Tanta University, Tanta, Egypt.
authors.forename: Lamia H
authors.initials: LH
authors.lastname: Elgarhy
authors.affiliation: Department of Dermatology & Venereology, Faculty of medicine, Tanta University, Tanta, Egypt.
authors.forename: Heba-Alla
authors.initials: HA
authors.lastname: Ellakkawy
authors.affiliation: Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
authors.forename: Nageh
authors.initials: N
authors.lastname: Elmahdy
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D002615:Chemexfoliation; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004890:Erythema / Q000209:etiology; D005148:Facial Dermatoses / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D050356:Lipid Metabolism; D014238:Trichloroacetic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D014973:Xanthomatosis / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*
chemical_list: D003879:Dermatologic Agents; D014238:Trichloroacetic Acid
keywords: CO2 laser; efficacy; trichloroacetic acid