title: Site-Selective Peptide/Protein Cleavage.
abstract: Site-selective peptide/protein degradation through chemical cleavage methods is an important modification of biologically relevant macromolecules which complements enzymatic hydrolysis. In this review, recent progress in chemical, site-selective peptide bond cleavage is overviewed, with an emphasis on postulated mechanisms and their implications on reactivity, selectivity, and substrate scope.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, and JST-ERATO, Kanai Life Science Catalysis Project, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors.forename: Jizhi
authors.initials: J
authors.lastname: Ni
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, and JST-ERATO, Kanai Life Science Catalysis Project, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. kanai@mol.f.u-tokyo.ac.jp.
authors.forename: Motomu
authors.initials: M
authors.lastname: Kanai
mesh_terms: D006868:Hydrolysis; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D010455:Peptides; D011506:Proteins
keywords: Cleavage; Degradation; Peptide bonds; Proteins; Site-selectivity