title: Impact of Hepatitis B Virus on Clinicopathological Features and Outcomes After Resection for Pancreatic Adenocarcinoma.
abstract: Background/ Aim: Chronic hepatitis B virus (HBV) infection is sometimes considered a risk factor for pancreatic cancer (PDAC), but the prognostic value of its presence has only rarely been investigated. The present study aimed to explore the impact of HBV after resection for PDAC.
  
  
  METHODS
  According to HBV surface antigen seroreactivity, 343 patients were classified as having non-viral or HBV-related cases of PDAC. Clinicopathological data and outcomes were comparatively assessed between the groups.
  
  
  RESULTS
  Chronic HBV infection was observed in 16 patients (4.5%). No significant differences between the HBV and non-viral cases of PDAC were observed. Tumor diameters (3.4 vs. 3.0, p=0.092) and stages at diagnosis (31 vs. 14% T1-T2, p=0.082) tended to differ between the groups, albeit without reaching significance. Completion of adjuvant therapy (63 vs. 54%, p=0.612), as well as median overall survival (15 vs. 17 months, p=0.346) was similar in the HBV and non-viral PDAC groups.
  
  
  CONCLUSIONS
  HBV-positive and virus-free patients with PDAC generally shared the same demographic, clinical and pathological profiles. HBV did not appear to have a detrimental effect on either early or long-term outcomes after resection for PDAC. Future studies searching for occult infection might, however, shed a different light on the role of HBV in PDAC.
authors.affiliation: Center of General Surgery and Liver Transplant, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Traian
authors.initials: T
authors.lastname: Dumitrascu
authors.affiliation: Nuclear Organization and Oncogene Unit, U993, Pasteur Institute, Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Pineau
authors.affiliation: Center of General Surgery and Liver Transplant, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Simona
authors.initials: S
authors.lastname: Dima
authors.affiliation: Center of General Surgery and Liver Transplant, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Cezar
authors.initials: C
authors.lastname: Stroescu
authors.affiliation: Center of General Surgery and Liver Transplant, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Brasoveanu
authors.affiliation: Department of Pathology, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Vlad
authors.initials: V
authors.lastname: Herlea
authors.affiliation: Center of General Surgery and Liver Transplant, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Mihnea
authors.initials: M
authors.lastname: Ionescu
authors.affiliation: Center of General Surgery and Liver Transplant, Fundeni Clinical Institute, Bucharest, Romania irinel.popescu220@gmail.com.
authors.forename: Irinel
authors.initials: I
authors.lastname: Popescu
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery* / Q000821:virology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003710:Demography; D005260:Female; D006515:Hepatitis B virus / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology*; D011182:Postoperative Care; D016896:Treatment Outcome
keywords: Pancreatic adenocarcinoma; hepatitis B virus; pancreatectomy