title: Prevalence of Metabolic Syndrome in Patients with HIV in the Era of Highly Active Antiretroviral Therapy.
abstract: OBJECTIVE
  Since the introduction of combination antiretroviral therapy (cART) as the standard of care for HIV disease, there has been a precipitous decline in the death rate due to HIV/ AIDS. The purpose of this study was to report the prevalence of metabolic syndrome in HIV infected patients.
  
  
  METHODS
  Retrospective, cross-sectional, observational study of 259 patients with HIV infection treated with cART from an urban community hospital. Metabolic syndrome prevalence was defined using the International Diabetes Federation (IDF) and the U.S. National Cholesterol Education Program Adult Treatment Panel III (ATP III) criteria. Study patients were included regardless of the duration of cART.
  
  
  RESULTS
  The prevalence of metabolic syndrome was 27% using IDF criteria and 26% using ATP III criteria. Logistic regression analysis found an association between treatment with the protease inhibitor darunavir and metabolic syndrome. (OR 3.32 with 95% confidence interval between 1.54 and 7.15).
  
  
  CONCLUSIONS
  There is a high prevalence of metabolic syndrome and obesity in HIV patients treated with cART, especially those taking the protease inhibitor darunavir.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Lombo
authors.forename: Imran
authors.initials: I
authors.lastname: Alkhalil
authors.forename: Marjorie P
authors.initials: MP
authors.lastname: Golden
authors.forename: Irma
authors.initials: I
authors.lastname: Fotjadhi
authors.forename: Sreedhar
authors.initials: S
authors.lastname: Ravi
authors.forename: Michael
authors.initials: M
authors.lastname: Virata
authors.forename: Marta
authors.initials: M
authors.lastname: Lievano
authors.forename: Jose
authors.initials: J
authors.lastname: Diez
authors.forename: Andre
authors.initials: A
authors.lastname: Ghantous
authors.forename: Thomas
authors.initials: T
authors.lastname: Donohue
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors