title: Food allergy and related risk factors in 2540 preschool children: an epidemiological survey in Guangdong Province, southern China.
abstract: BACKGROUND
  Although the number of studies on allergic diseases in the general population of southern China is increasing, only a few have addressed food allergy (FA) in children in this region. The present study aimed to investigate the prevalence, clinical manifestations, spectrum of allergens, and related risk factors of FA in preschool children in Guangdong Province, southern China.
  
  
  METHODS
  A random cluster-sampling method was used to select 24 kindergartens from 12 cities in Guangdong Province. The parents or guardians of the children were requested to complete a questionnaire on general information and data regarding FA diagnosis and symptoms in the children and their first-degree relatives. Thereafter, the Chi-square test, multivariate regression analysis, and Spearman's rank-order correlation coefficient analysis were performed to identify statistically significant differences.
  
  
  RESULTS
  Analysis of 2540 valid questionnaires revealed an FA prevalence rate of 4%. Adverse food reactions were due to the consumption of shrimp (4.4%), crab (3.2%), mango (2.3%), cow's milk and dairy products (1.9%), and eggs (1.4%). Logistic regression analysis indicated that a history of FA and a history of allergic rhinitis in the first-degree relatives were the major factors leading to FA in children.
  
  
  CONCLUSIONS
  The incidence of FA in children in Guangdong Province is higher than that commonly believed. An individual's genetic background is an important risk factor for FA. Hence, mitigation of the impact of lifestyle and environmental factors should be carefully considered to reduce the incidence of childhood FA.
authors.affiliation: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Guang-Qiao
authors.initials: GQ
authors.lastname: Zeng
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: Luo
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Huang
authors.forename: Pei-Yan
authors.initials: PY
authors.lastname: Zheng
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Luo
authors.forename: Ni-Li
authors.initials: NL
authors.lastname: Wei
authors.forename: Bao-Qing
authors.initials: BQ
authors.lastname: Sun
mesh_terms: D017677:Age Distribution; D000485:Allergens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D003430:Cross-Sectional Studies; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D011795:Surveys and Questionnaires
chemical_list: D000485:Allergens