title: Secular trends of pregnancies in women with inflammatory connective tissue disease.
abstract: BACKGROUND
  This study examined secular trends in reproductive outcome in women with inflammatory connective tissue disease compared with reference deliveries from the general population.
  
  
  METHODS
  Historical cohort study based on data registered in the Medical Birth Register of Norway from 1967 to 2009. The study included singleton births in women recorded with connective tissue disease (n = 851) and reference deliveries from the general population (n = 2 437 110). Births were stratified in four periods, 1967-1979, 1980-1989, 1990-1999 and 2000-2009. Associations between connective tissue disease and maternal and perinatal outcomes by decade were assessed in logistic regression analyses and adjusted for maternal age at delivery and parity.
  
  
  RESULTS
  In the 1970s, around 2.7 deliveries/year were registered for women with connective tissue disease (0.004% of all deliveries). This increased to 42 deliveries/year (0.07% of all deliveries) after 2000. Adjusted odds ratios (aOR) for cesarean section were 5.0 (95% CI 2.1-11.9) in the first and 1.8 (95% CI 1.4-2.3) in the last period. For preterm delivery the aOR decreased from 4.9 (95% CI 2.1-11.4) to 3.1 (95% CI 2.3-4.2) and the aOR for birthweight <2500 g changed from 7.3 (95% CI 3.3-16.3) to 4.1 (95% CI 3.0-5.6).
  
  
  CONCLUSIONS
  An increasing number of births were observed over time among women with connective tissue disease. Adverse pregnancy outcomes were more common among women with connective tissue disease but risks have decreased over time.
authors.affiliation: National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital, Trondheim, Norway.|Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Marianne
authors.initials: M
authors.lastname: Wallenius
authors.affiliation: National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital, Trondheim, Norway.|Department of Laboratory Medicine, Women's and Child Health, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Kjell Å
authors.initials: KÅ
authors.lastname: Salvesen
authors.affiliation: Department of Global Public Health and Primary Health Care, University of Bergen, Bergen, Norway.|Medical Birth Registry of Norway, Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway.
authors.forename: Anne K
authors.initials: AK
authors.lastname: Daltveit
authors.affiliation: National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Johan F
authors.initials: JF
authors.lastname: Skomsvoll
mesh_terms: D000328:Adult; D001724:Birth Weight; D002585:Cesarean Section / Q000639:trends; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology; D003240:Connective Tissue Diseases / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016015:Logistic Models; D008423:Maternal Age; D009664:Norway / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology; D012042:Registries
keywords: Birth register; cohort study; connective tissue disease; number of pregnancies; pregnancy complications; secular trends