title: Assessment of muscle tissue oxygen saturation after out-of-hospital cardiac arrest.
abstract: OBJECTIVE
  Pathophysiology of cardiac arrest corresponds to an ischemia-reperfusion syndrome with deep impairment of microcirculation. Muscular tissue oxygen saturation (StO2) is a noninvasive method of evaluation of microcirculation. Our study was aimed at assessing the prognosis value of muscular StO2 in patients admitted for out-of-hospital cardiac arrest (OHCA) and treated with hypothermia.
  
  
  METHODS
  We conducted a prospective bicentric observational study including OHCA patients treated with therapeutic hypothermia. Baseline StO2, derived variables (desaturation and resaturation slopes), and lactate levels were compared at different times between patients with good and poor outcomes. Prognosis was assessed by the Cerebral Performance Category (CPC) score at 6 months after admission (CPC 1-2, good outcome; CPC 3-5, poor outcome).
  
  
  RESULTS
  Forty-four patients were included, 17 good and 27 poor outcomes at 6 months. At admission, StO2 and lactate levels were lower in good outcome patients. Desaturation and resaturation slopes did not differ between groups.
  
  
  CONCLUSIONS
  After an OHCA treated with therapeutic hypothermia, StO2 was correlated with outcome. Further research is needed to better understand the pathophysiological process underlying our results.
authors.affiliation: Réanimation Médico-Chirurgicale, Hôpital Saint-Roch, Nice University Hospital, 06000 Nice, France. Electronic address: orban.jc@chu-nice.fr.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Orban
authors.affiliation: Réanimation Médico-Chirurgicale, Hôpital Saint-Roch, Nice University Hospital, 06000 Nice, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Scarlatti
authors.affiliation: Réanimation Médicale, Hôpital de l'Archet, Nice University Hospital, 06200 Nice, France.
authors.forename: Pierre-Eric
authors.initials: PE
authors.lastname: Danin
authors.affiliation: Réanimation Médicale, Hôpital de l'Archet, Nice University Hospital, 06200 Nice, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Dellamonica
authors.affiliation: Réanimation Médicale, Hôpital de l'Archet, Nice University Hospital, 06200 Nice, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Bernardin
authors.affiliation: Réanimation Médico-Chirurgicale, Hôpital Saint-Roch, Nice University Hospital, 06000 Nice, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Ichai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007035:Hypothermia; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000628:therapy*; D010100:Oxygen / Q000737:chemistry*; D010343:Patient Admission; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Out-of-hospital cardiac arrest; Outcome; Tissular saturation of oxygen