title: Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery.
abstract: A new class of thermoresponsive random polyurethanes is successfully synthesized and characterized. Poly(ethylene glycol) diol (Mn = 1500 Da) and 2,2-dimethylolpropionic acid are reacted with isophorone diisocyanate in the presence of methane sulfonic acid catalyst. It is found that these polyurethanes are thermoresponsive in aqueous media and manifest a lower critical solution temperature (LCST) that can be easily tuned from 30 °C to 70 °C by increasing the poly(ethylene glycol) content. Their sharp LCST transitions make these random polyurethanes ideal candidates for stimuli-responsive drug delivery applications. To that end, the ability of these systems to efficiently sequester doxorubicin (up to 36 wt%) by means of a sonication/dialysis method is successfully demonstrated. Additionally, it is also demonstrated that accelerated doxorubicin release kinetics from the nanoparticles can be attained above the LCST.
authors.affiliation: POLYMAT, University of the Basque Country UPV/EHU Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-San Sebastián, Spain.
authors.forename: Haritz
authors.initials: H
authors.lastname: Sardon
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore, 138669, Singapore.
authors.forename: Jeremy P K
authors.initials: JP
authors.lastname: Tan
authors.affiliation: IBM Almaden Research Center, 650 Harry Road, San Jose, CA, 95120, USA.
authors.forename: Julian M W
authors.initials: JM
authors.lastname: Chan
authors.affiliation: POLYMAT, University of the Basque Country UPV/EHU Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-San Sebastián, Spain.
authors.forename: Daniele
authors.initials: D
authors.lastname: Mantione
authors.affiliation: POLYMAT, University of the Basque Country UPV/EHU Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-San Sebastián, Spain.|Ikerbasque, Basque Foundation for Science, E-48011, Bilbao, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Mecerreyes
authors.affiliation: IBM Almaden Research Center, 650 Harry Road, San Jose, CA, 95120, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Hedrick
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore, 138669, Singapore.
authors.forename: Yi Yan
authors.initials: YY
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D056945:Hep G2 Cells; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry*; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011140:Polyurethanes; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: LCST; drug-loading; nanoparticles; organocatalysis; polyurethanes