title: Addicted to AA (Acetoacetate): A Point of Convergence between Metabolism and BRAF Signaling.
abstract: In this issue Kang et al. (2015) show that oncogenic BRAF(V600E) stimulates expression of ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA lyase and promotes the formation of the ketone body acetoacetate, which subsequently enhances BRAF(V600E)/MEK/ERK signaling.
authors.affiliation: Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Trousil
authors.affiliation: Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: bin.zheng@cbrc2.mgh.harvard.edu.
authors.forename: Bin
authors.initials: B
authors.lastname: Zheng
mesh_terms: D006801:Humans; D007943:Leukemia, Hairy Cell / Q000378:metabolism*; D048369:MAP Kinase Kinase 1 / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism*; D050811:Octamer Transcription Factor-1 / Q000378:metabolism*; D007652:Oxo-Acid-Lyases / Q000378:metabolism*; D048493:Proto-Oncogene Proteins B-raf / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D050811:Octamer Transcription Factor-1; D048493:Proto-Oncogene Proteins B-raf; D048369:MAP Kinase Kinase 1; D007652:Oxo-Acid-Lyases