title: Physical activity, sedentary behavior time and lipid levels in the Observation of Cardiovascular Risk Factors in Luxembourg study.
abstract: BACKGROUND
  Recently attention has been drawn to the health impacts of time spent engaging in sedentary behaviors. While many studies have investigated general physical activity (PA) in relation to blood lipid levels, the current study aimed to examine the intensity of activity, including sedentary behavior time, and time spent engaging in moderate and intense PA, with concentrations of HDL and LDL-cholesterol, total cholesterol, and triglycerides.
  
  
  METHODS
  Participants comprised 1331 individuals, aged 18 to 70 years, from the Observation of Cardiovascular Risk Factors in Luxembourg (ORISCAV-LUX) study, who underwent objective cardiovascular health assessments and completed the International Physical Activity Questionnaire (IPAQ). Time spent engaging in sedentary behaviors (screen time on a workday and a day off, and total sitting time on a work day), and moderate and intense PA, were related to levels of HDL and LDL-cholesterol, total cholesterol, and triglycerides. Analyses were conducted in the whole sample, and then with stratification according to BMI (normal weight versus overweight/obese).
  
  
  RESULTS
  Both lower screen time during days off and higher intense PA time were significantly associated with higher HDL-cholesterol after full adjustment for socio-demographic factors, dietary factors and smoking (both p < 0.05). In normal weight individuals, consistent positive relations between triglycerides, LDL, and total cholesterol with all sedentary behavior time variables were observed (all p < 0.05; adjusted for age, education, gender). There were no statistically significant associations between any intensity level of PA or sedentary behavior time variable and lipid levels in those overweight or obese.
  
  
  CONCLUSIONS
  Spending less time in sedentary behaviors, and engaging in medium levels of intense physical activity may be associated with a more favorable blood lipid profile, particularly with regard to levels of HDL and triglycerides.
authors.affiliation: Nutritional Physiology Research Centre, University of South Australia, GPO Box 2471, Adelaide, 5001, Australia. georgina.crichton@unisa.edu.au.|Luxembourg Institute of Health, Grand-Duchy of Luxembourg, Luxembourg, Luxembourg. georgina.crichton@unisa.edu.au.
authors.forename: Georgina E
authors.initials: GE
authors.lastname: Crichton
authors.affiliation: Luxembourg Institute of Health, Grand-Duchy of Luxembourg, Luxembourg, Luxembourg. Alaa.Alkerwi@lih.lu.
authors.forename: Ala'a
authors.initials: A
authors.lastname: Alkerwi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D003710:Demography; D004032:Diet; D005260:Female; D006262:Health; D006801:Humans; D008055:Lipids / Q000097:blood*; D008189:Luxembourg / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D012307:Risk Factors; D057185:Sedentary Behavior; D013997:Time Factors; D055815:Young Adult
chemical_list: D008055:Lipids