title: The short and long telomere syndromes: paired paradigms for molecular medicine.
abstract: Recent advances have defined a role for abnormally short telomeres in a broad spectrum of genetic disorders. They include rare conditions such as dyskeratosis congenita as well pulmonary fibrosis and emphysema. Now, there is new evidence that some familial cancers, such as melanoma, are caused by mutations that lengthen telomeres. Here, we examine the significance of these short and long telomere length extremes for understanding the molecular basis of age-related disease and cancer.
authors.affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Stanley
authors.affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States. Electronic address: marmani1@jhmi.edu.
authors.forename: Mary
authors.initials: M
authors.lastname: Armanios
mesh_terms: D000375:Aging / Q000235:genetics* / Q000473:pathology; D006801:Humans; D062346:Molecular Medicine; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D019098:Telomerase / Q000235:genetics; D016615:Telomere / Q000235:genetics*; D059505:Telomere Homeostasis / Q000235:genetics; D059506:Telomere Shortening / Q000235:genetics
chemical_list: D019098:Telomerase