title: [Chemical constituents from Morus notabilis and their cytotoxic effect].
abstract: Une new flavonoids named as notabilisin K (1), together with four known compounds, morusin (2), mulberrofuran A (3), neocyclomorusin (4) and mornigrol F (5) are separated from 95% ethanol extracts of the twigs of Morus notabilis. Compounds 2-5 are separated from this plant for the first time. Notabilisin I, notabilisin J exhibits certain effect against cells of HCT-116, HepG2 and A2780 with IC50 values ranging from 1.47 μmol x L(-1) to 5.46 μmol x L(-1). Morusin exhibits strong effect against five kinds of human cancer cells (BGC823, A2780, HCT-116, HepG2 and NCI-H1650) with IC50 values ranging from 0.74 μmol x L(-1) to 1.58 μmol x L(-1).
authors.forename: Pan
authors.initials: P
authors.lastname: Zhen
authors.forename: Gang
authors.initials: G
authors.lastname: Ni
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Ruo-yun
authors.initials: RY
authors.lastname: Chen
authors.forename: Han-ze
authors.initials: HZ
authors.lastname: Yang
authors.forename: De-quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry; D001572:Benzofurans / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D031625:Morus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D005419:Flavonoids; D010936:Plant Extracts; D013729:Terpenes; C057451:morusin