title: A network map of Interleukin-10 signaling pathway.
abstract: Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and Trypanosoma cruzi inside the host. The signaling mechanisms of IL-10 cytokine are not well explored and a well annotated pathway map has been lacking. To this end, we developed a pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature. The reactions were categorized under molecular associations, activation/inhibition, catalysis, transport and gene regulation. In all, 37 molecules and 76 reactions were annotated. The IL-10 signaling pathway can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by our group.
authors.affiliation: International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore, 560 066, India.|School of Biotechnology, KIIT University, Bhubaneswar, Odisha, 751 024, India.
authors.forename: Renu
authors.initials: R
authors.lastname: Verma
authors.affiliation: International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore, 560 066, India.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Balakrishnan
authors.affiliation: Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
authors.forename: Kusum
authors.initials: K
authors.lastname: Sharma
authors.affiliation: International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore, 560 066, India.|School of Biotechnology, KIIT University, Bhubaneswar, Odisha, 751 024, India.
authors.forename: Aafaque Ahmad
authors.initials: AA
authors.lastname: Khan
authors.affiliation: International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore, 560 066, India.|Manipal University, Madhav Nagar, Manipal, 576 104, India.
authors.forename: Jayshree
authors.initials: J
authors.lastname: Advani
authors.affiliation: International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore, 560 066, India.|YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India.
authors.forename: Harsha
authors.initials: H
authors.lastname: Gowda
authors.affiliation: Department of Microbiology, National JALMA Institute for Leprosy & Other Mycobacterial Diseases (Indian Council of Medical Research), Agra, 282 004, India.
authors.forename: Srikanth Prasad
authors.initials: SP
authors.lastname: Tripathy
authors.affiliation: School of Biotechnology, KIIT University, Bhubaneswar, Odisha, 751 024, India.
authors.forename: Mrutyunjay
authors.initials: M
authors.lastname: Suar
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD, USA.|Departments of Biological Chemistry, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD, 21205, USA.|Departments of Oncology, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD, 21205, USA.|Departments of Pathology, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD, 21205, USA.
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Pandey
authors.affiliation: CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110 020, India.
authors.forename: Sheetal
authors.initials: S
authors.lastname: Gandotra
authors.affiliation: International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore, 560 066, India. keshav@ibioinformatics.org.|NIMHANS-IOB Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India. keshav@ibioinformatics.org.|YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India. keshav@ibioinformatics.org.
authors.forename: T S Keshava
authors.initials: TS
authors.lastname: Prasad
authors.affiliation: Command Hospital (Air Force), Bangalore, 560 007, India. shankarsid@gmail.com.
authors.forename: Subramanian
authors.identifier: http://orcid.org/0000-0001-9415-2969
authors.initials: S
authors.lastname: Shankar
keywords: Co-stimulatory molecules; Interferon-gamma (IFN-γ); Lipopolysaccharides; NetSlim; Pro-inflammatory cytokines; Protein-protein interactions; Systems biology markup language; Translocation