title: Macroevolutionary developmental biology: Embryos, fossils, and phylogenies.
abstract: The field of evolutionary developmental biology is broadly focused on identifying the genetic and developmental mechanisms underlying morphological diversity. Connecting the genotype with the phenotype means that evo-devo research often considers a wide range of evidence, from genetics and morphology to fossils. In this commentary, we provide an overview and framework for integrating fossil ontogenetic data with developmental data using phylogenetic comparative methods to test macroevolutionary hypotheses. We survey the vertebrate fossil record of preserved embryos and discuss how phylogenetic comparative methods can integrate data from developmental genetics and paleontology. Fossil embryos provide limited, yet critical, developmental data from deep time. They help constrain when developmental innovations first appeared during the history of life and also reveal the order in which related morphologies evolved. Phylogenetic comparative methods provide a powerful statistical approach that allows evo-devo researchers to infer the presence of nonpreserved developmental traits in fossil species and to detect discordant evolutionary patterns and processes across levels of biological organization.
authors.affiliation: Department of Microbiology and Immunology, Montana State University, Bozeman, Montana.|Department of Earth Sciences, Montana State University, Bozeman, Montana.
authors.forename: Chris L
authors.initials: CL
authors.lastname: Organ
authors.affiliation: Department of Anatomy and Neurobiology, NEOMED, Rootstown, Ohio.
authors.forename: Lisa Noelle
authors.initials: LN
authors.lastname: Cooper
authors.affiliation: Department of Anatomy and Neurobiology, NEOMED, Rootstown, Ohio.
authors.forename: Tobin L
authors.initials: TL
authors.lastname: Hieronymus
mesh_terms: D000818:Animals; D015509:Developmental Biology / Q000379:methods*; D004625:Embryo, Nonmammalian; D005580:Fossils; D015233:Models, Statistical; D010802:Phylogeny; D014714:Vertebrates
keywords: embryos; evolutionary developmental biology; fossils; macroevolution; phylogenetic comparative methods