title: Teriparatide Versus Alendronate for the Preservation of Bone Mineral Density After Total Hip Arthroplasty - A randomized Controlled Trial.
abstract: In this study, the effect of teriparatide for the prevention of bone mineral density (BMD) loss after THA was compared with alendronate in a randomized controlled trial. Forty-eight patients were assigned to three groups, namely, the teriparatide, alendronate, and no medication groups. Dual-energy x-ray absorptiometry (DEXA) was performed at 1 week post-surgery as a baseline reference, followed by subsequent measurements at 12, 24, and 48 weeks postoperatively. For periprosthetic BMD loss, a significant effect of teriparatide was demonstrated, though its effect was similar to alendronate. On the other hand, higher lumbar BMD was observed in the teriparatide group than in the alendronate group at 48 weeks post-surgery. Teriparatide administration may be one reasonable option for osteoporotic patient to preserve the periprosthetic BMD after THA.
authors.affiliation: Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Kobayashi
authors.affiliation: Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inaba
authors.affiliation: Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Uchiyama
authors.affiliation: Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ike
authors.affiliation: Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
authors.forename: So
authors.initials: S
authors.lastname: Kubota
authors.affiliation: Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Saito
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D019386:Alendronate / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip; D015992:Body Mass Index; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000601:surgery*; D010024:Osteoporosis / Q000628:therapy; D019379:Teriparatide / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D050071:Bone Density Conservation Agents; D019379:Teriparatide; D019386:Alendronate
keywords: alendronate; bone mineral density; dual-energy x-ray absorptiometry; teriparatide; total hip arthroplasty