title: A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study.
abstract: OBJECTIVE
  Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database.
  
  
  METHODS
  Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile.
  
  
  RESULTS
  30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56.
  
  
  CONCLUSIONS
  This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.
authors.affiliation: Dept. of Clinical Sciences & Community Health, University of Milano, Milano, Italy; Division of Rheumatology, Istituto Gaetano Pini, Milano, Italy. Electronic address: francesca.ingegnoli@unimi.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Ingegnoli
authors.affiliation: Dept. of Clinical Sciences & Community Health, University of Milano, Milano, Italy; Medical Statistics and Biometry, Milano, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Boracchi
authors.affiliation: Division of Rheumatology, Istituto Gaetano Pini, Milano, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Gualtierotti
authors.affiliation: University of Ghent, Department of Rheumatology, Gent University Hospital, Gent, Belgium.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Smith
authors.affiliation: Research Laboratory and Academic Division of Clinical Rheumatology, University of Genova, Genova, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cutolo
authors.affiliation: Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany.
authors.forename: Ivan
authors.initials: I
authors.lastname: Foeldvari
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002196:Capillaries / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D020678:Microscopic Angioscopy; D008875:Middle Aged; D012189:Retrospective Studies; D012594:Scleroderma, Localized / Q000473:pathology*; D012595:Scleroderma, Systemic / Q000473:pathology*; D055815:Young Adult
keywords: Capillaroscopy; EUSTAR; Juvenile systemic sclerosis; Microcirculation; Nailfold capillaroscopy; Systemic sclerosis; Videocapillaroscopy