title: Extracardiac rhabdomyomas--presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling.
abstract: Extracardiac rhabdomyomas (RM) are very rare benign tumors with a poorly understood pathogenesis. In this report we describe two RM cases--a sublingual adult type tumor and a genital type tumor involving the uterine cervix. The patho-clinical characteristics, as well as the pioneer immunohistochemical analysis of ERK1/2 and AKT/mTOR pathway status is included. The expression of key proteins involved in above signaling gives new insight into the biology of extracardiac RM.
authors.forename: Ewa
authors.initials: E
authors.lastname: Iżycka-Świeszewska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wesołowski
authors.affiliation: Blanka Hermann, Pathology and Neuropathology Department, Medical University in Gdansk, Debinki 1, 80-211 Gdansk, Poland, e-mail: blankahh@gumed.edu.pl.
authors.forename: Blanka
authors.initials: B
authors.lastname: Hermann
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D019950:Mitogen-Activated Protein Kinase 1 / Q000032:analysis*; D048052:Mitogen-Activated Protein Kinase 3 / Q000032:analysis*; D051057:Proto-Oncogene Proteins c-akt / Q000032:analysis*; D012207:Rhabdomyoma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D015398:Signal Transduction; D013362:Sublingual Gland Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D058570:TOR Serine-Threonine Kinases / Q000032:analysis*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; C546842:MTOR protein, human; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3