title: Chronic cannabis use and ERP correlates of visual selective attention during the performance of a flanker go/nogo task.
abstract: The aim of the study was to investigate the relationship between chronic cannabis use and visual selective attention by examining event-related potentials (ERPs) during the performance of a flanker go/nogo task. Male participants were 15 chronic cannabis users (minimum two years use, at least once per week) and 15 drug naive controls. Cannabis users showed longer reaction times compared to controls with equivalent accuracy. Cannabis users also showed a reduction in the N2 'nogo effect' at frontal sites, particularly for incongruent stimuli, and particularly in the right hemisphere. This suggests differences between chronic cannabis users and controls in terms of inhibitory processing within the executive control network, and may implicate the right inferior frontal cortex. There was also preliminary evidence for differences in early selective attention, with controls but not cannabis users showing modulation of N1 amplitude by flanker congruency. Further investigation is required to examine the potential reversibility of these residual effects after long-term abstinence and to examine the role of early selective attention mechanisms in more detail.
authors.affiliation: School of Medicine (Psychology), University of Tasmania, Private Bag 30, Hobart, Tasmania 7000, Australia.
authors.forename: Clare
authors.initials: C
authors.lastname: Nicholls
authors.affiliation: School of Medicine (Psychology), University of Tasmania, Private Bag 30, Hobart, Tasmania 7000, Australia.
authors.forename: Raimondo
authors.initials: R
authors.lastname: Bruno
authors.affiliation: School of Medicine (Psychology), University of Tasmania, Private Bag 30, Hobart, Tasmania 7000, Australia. Electronic address: Allison.Matthews@utas.edu.au.
authors.forename: Allison
authors.initials: A
authors.lastname: Matthews
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects* / Q000502:physiology; D016022:Case-Control Studies; D005071:Evoked Potentials / Q000502:physiology*; D056344:Executive Function / Q000187:drug effects* / Q000502:physiology; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects*; D055815:Young Adult
keywords: Cannabis use; ERPs; Flanker; Go/nogo; N1; N2; Selective attention