title: [Transglutaminase and neurodegenerative diseases].
abstract: Transglutaminase (TG) is a kind of calcium-dependent enzymes. The TGase family found in rodents and human contains 9 types, including TG1-7, blood coagulation factor XIIIa and erythrocyte membrane protein 4.2, with the former 8 types possessing catalytic activity. TG catalyzes various conversion reactions of glutamine, including transamination, deamination and esterification, and participates in post-transcriptional modification of proteins such as cross-linking peptides glutamine residue and lysyl-residue, stabilizing protein structure and catalyzing formation of protein aggregates. TGase has been found to contribute to a variety of important physiological and pathological processes and play a role in the pathogenesis of multiple diseases. Notably, neurodegenerative diseases such as Huntington's disease, spinocerebellar ataxia, Alzheimer's disease and Parkinson's disease, have a close connection with TGase's role in the human body.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China. wjling8002@126.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Junsheng
authors.initials: J
authors.lastname: Zeng
authors.forename: Sheng
authors.initials: S
authors.lastname: Zeng
authors.forename: Beisha
authors.initials: B
authors.lastname: Tang
authors.forename: Junling
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000201:enzymology* / Q000235:genetics; D011503:Transglutaminases / Q000235:genetics / Q000378:metabolism*
chemical_list: D011503:Transglutaminases