title: Isotretinoin treatment in patients with acne vulgaris: does it impact muscle strength, fatigue, and endurance?
abstract: The objective of this study was to evaluate the effects of isotretinoin on muscle strength, fatigue, and endurance in patients with acne vulgaris. The study included 27 patients with acne vulgaris who underwent treatment with isotretinoin as well as 26 control patients for comparison. Participants in the treatment group received oral isotretinoin 0.5 mg/kg once daily for 1 month followed by an increased dose of 1 mg/kg once daily for 2 months. Isokinetic measurements were obtained from the hamstrings and quadriceps on the nondominant side of the body at baseline and 3-month follow-up using an isokinetic dynamometer. Results indicated that systemic isotretinoin did not significantly alter muscle strength, fatigue, and endurance.
authors.forename: Mustafa Turgut
authors.initials: MT
authors.lastname: Yıldızgören
authors.forename: Emine Nur
authors.initials: EN
authors.lastname: Rifaioğlu
authors.forename: Musa
authors.initials: M
authors.lastname: Demirkapı
authors.affiliation: Türkocağı St. No: 3 Sıhhiye 06230 Ankara/Turkey. timurekiz@gmail.com.
authors.forename: Timur
authors.initials: T
authors.lastname: Ekiz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Micooğulları
authors.forename: Tuğba
authors.initials: T
authors.lastname: Şen
authors.forename: Ayşe Dicle
authors.initials: AD
authors.lastname: Turhanoğlu
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects; D053580:Muscle Strength / Q000187:drug effects*; D053581:Muscle Strength Dynamometer; D010807:Physical Endurance / Q000187:drug effects; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin