title: [PIPAC--Pressurized intraperitoneal aerosol chemotherapy. A novel treatment for peritoneal carcinomatosis].
abstract: Peritoneal carcinomatosis remains a diagnostic challenge with sparse treatment options. The effect of systemic chemotherapy remains limited inside the peritoneum due to low penetration and a relative resistance of peritoneal nodules. Heated IntraPeritoneal Chemotherapy (HIPEC) improves survival in selected patients but entails a high incidence of complications. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) allows to disperse the active agents inside the peritoneal cavity by laparoscopy. Distribution and tissue penetration of chemotherapy by PIPAC are superior to HIPEC and systemic chemotherapy despite of lower doses. Systemic side effects are uncommon and surgical trauma is limited. Histological and clinical response rates in platinum-resistant patients approach 70% and survival data appear to be favorable compared with standard therapy.
authors.forename: Martin
authors.initials: M
authors.lastname: Hübner
authors.forename: Hugo
authors.initials: H
authors.lastname: Teixeira
authors.forename: Tarek
authors.initials: T
authors.lastname: Boussaha
authors.forename: Matthieu
authors.initials: M
authors.lastname: Cachemaille
authors.forename: Kuno
authors.initials: K
authors.lastname: Lehmann
authors.forename: Nicolas
authors.initials: N
authors.lastname: Demartines
mesh_terms: D000336:Aerosols; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006801:Humans; D010535:Laparoscopy; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D011312:Pressure
chemical_list: D000336:Aerosols; D000970:Antineoplastic Agents