title: Powder metallurgical low-modulus Ti-Mg alloys for biomedical applications.
abstract: In this work, powder metallurgical (PM) Ti-Mg alloys were prepared using combined techniques of mechanical alloying and spark plasma sintering. The alloys mainly consist of super saturations of Mg in Ti matrix, and some laminar structured Ti- and Mg-rich phases. The PM Ti-Mg alloys contain a homogeneous mixtures of nanocrystalline Mg and Ti phases. The novel microstructures result in unconventional mechanical and biological properties. It has been shown that the PM Ti-Mg alloys have a much lower compression modulus (36-50GPa) compared to other Ti alloys, but still remain a very high compressive strength (1500-1800MPa). In addition, the PM Ti-Mg alloys show good biocompatibility and bioactivity. Mg can dissolve in the simulated body fluids, and induce the formation of the calcium phosphate layer. The compression modulus of PM Ti-Mg alloys decreases with the amount of Mg, while the bioactivity increases. Although the corrosion resistance of Ti-Mg alloys decreases with the content of Mg, the alloys still show good stability in simulated body fluid under electrochemical conditions. The indirect and direct cytotoxicity results show that PM Ti-Mg alloys have a good biocompatibility to NIH-3T3 cells. Therefore, the PM Ti-Mg alloys are promising candidates in biomedical applications.
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China. Electronic address: yonliu@csu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China.
authors.forename: Kaiyang
authors.initials: K
authors.lastname: Li
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Song
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China. Electronic address: wuhong927@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410078, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China.
authors.forename: Yanni
authors.initials: Y
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Cheng
authors.affiliation: Department of Mechanical & Biomedical Engineering, City University of Hong Kong, Hong Kong, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Mechanical & Biomedical Engineering, City University of Hong Kong, Hong Kong, PR China.
authors.forename: Xinrui
authors.initials: X
authors.lastname: Niu
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha 410078, PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha 410078, PR China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Porous Metal Materials, Northwestern Institute of Nonferrous Metals Research, Xi'an 7100012, PR China.
authors.forename: Huiping
authors.initials: H
authors.lastname: Tang
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D008345:Manganese / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D008669:Metallurgy; D051379:Mice; D041681:NIH 3T3 Cells; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000497:Alloys; D008345:Manganese; D014025:Titanium
keywords: Bioactivity; Biomaterials; Mechanical behavior; Powder metallurgy; Ti–Mg alloy