title: Improving preclinical models of HIV microbicide efficacy.
abstract: Despite potent in vitro efficacy, most topical microbicides fail to effectively prevent HIV transmission. One reason for clinical failure may be that current microbicide testing does not reflect the environment encountered during sexual virus transmission. We discuss how preclinical microbicide development could be improved by more closely mimicking real-life conditions.
authors.affiliation: Department of Urology, University of California, San Francisco, San Francisco, CA 94158, USA; Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.
authors.forename: Nadia R
authors.initials: NR
authors.lastname: Roan
authors.affiliation: Institute of Molecular Virology, UPEP, Ulm University Medical Centre, Meyerhofstrasse 1, 89081 Ulm, Germany; Ulm Peptide Pharmaceuticals, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Electronic address: jan.muench@uni-ulm.de.
authors.forename: Jan
authors.initials: J
authors.lastname: Münch
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004195:Disease Models, Animal; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission*; D006801:Humans; D008962:Models, Theoretical
chemical_list: D000890:Anti-Infective Agents
keywords: HIV-1; amyloids; microbicide; semen; transmission; vaginal fluid