title: mTOR and its tight regulation for iNKT cell development and effector function.
abstract: Invariant NKT (iNKT) cells, which express the invariant Vα14Jα18 TCR that recognizes lipid antigens, have the ability to rapidly respond to agonist stimulation, producing a variety of cytokines that can shape both innate and adaptive immunity. iNKT cells have been implicated in host defense against microbial infection, in anti-tumor immunity, and a multitude of diseases such as allergies, asthma, graft versus host disease, and obesity. Emerging evidence has demonstrated crucial role for mammalian target of rapamycin (mTOR) in immune cells, including iNKT. In this review we will discuss current understanding of how mTOR and its tight regulation control iNKT cell development, effector lineage differentiation, and function.
authors.affiliation: Department of Medicine, University of California Irvine, Irvine, CA 92868, United States.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Pediatrics and Immunology, Duke University Medical Center, Durham, NC 27710, United States.
authors.forename: Balachandra
authors.initials: B
authors.lastname: Gorentla
authors.affiliation: Department of Pediatrics and Immunology, Duke University Medical Center, Durham, NC 27710, United States. Electronic address: xiaoping.zhong@duke.edu.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Zhong
authors.affiliation: Department of Microbiology, Inha Research Institute for Medical Sciences, College of Medicine, Inha University, Incheon 400-712, Republic of Korea. Electronic address: shin001@inha.ac.kr.
authors.forename: Jinwook
authors.initials: J
authors.lastname: Shin
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D055611:Natural Killer T-Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D058570:TOR Serine-Threonine Kinases / Q000276:immunology* / Q000378:metabolism
chemical_list: D058570:TOR Serine-Threonine Kinases
keywords: CARMA1; Diacylglycerol kinases; PTEN; Raptor; Ras; RasGRP1; Rictor; Signal transduction; TSC1/2; iNKT cell; iNKT1; iNKT17; iNKT2; mTOR