title: Global Database-Driven Assessment of HIV-1 Adaptation to the Immune Repertoires of Human Populations.
abstract: Associations between HIV-1 cytotoxic T lymphocyte (CTL) escape mutations and their restricting human leukocyte antigen (HLA) alleles imply that HIV could adapt to divergent HLA repertoires of human populations globally. Using publicly available databases, we examine the relationship between the frequencies of 19 experimentally validated CTL escape mutations in HIV-1 reverse transcriptase and their restricting HLA alleles in 59 countries. From these extensive data, we find evidence of differential HIV adaptations to human populations at only a limited number of the studied epitope sites.
authors.affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
authors.forename: Aram
authors.initials: A
authors.lastname: Karakas
authors.affiliation: Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
authors.forename: Zabrina L
authors.initials: ZL
authors.lastname: Brumme
authors.affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada Department of Medicine, University of British Columbia, Vancouver, Canada apoon@cfenet.ubc.ca.
authors.forename: Art F Y
authors.initials: AF
authors.lastname: Poon
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics* / Q000276:immunology; D000483:Alleles; D000595:Amino Acid Sequence; D030541:Databases, Genetic; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D005787:Gene Frequency; D014644:Genetic Variation; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006801:Humans; D057131:Immune Evasion; D008969:Molecular Sequence Data; D009154:Mutation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000473:pathology / Q000821:virology*
chemical_list: D000939:Epitopes; D006680:HLA Antigens; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase