title: Aptamers against pathogenic microorganisms.
abstract: An important current issue of modern molecular medicine and biotechnology is the search for new approaches to early diagnostic assays and adequate therapy of infectious diseases. One of the promising solutions to this problem might be a development of nucleic acid aptamers capable of interacting specifically with bacteria, protozoa, and viruses. Such aptamers can be used for the specific recognition of infectious agents as well as for blocking of their functions. The present review summarizes various modern SELEX techniques used in this field, and of several currently identified aptamers against viral particles and unicellular organisms, and their applications. The prospects of applying nucleic acid aptamers for the development of novel detection systems and antibacterial and antiviral drugs are discussed.
authors.affiliation: a Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences , Novosibirsk , Russia and.
authors.forename: Anna
authors.initials: A
authors.lastname: Davydova
authors.affiliation: a Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences , Novosibirsk , Russia and.
authors.forename: Maria
authors.initials: M
authors.lastname: Vorobjeva
authors.affiliation: a Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences , Novosibirsk , Russia and.
authors.forename: Dmitrii
authors.initials: D
authors.lastname: Pyshnyi
authors.affiliation: b Department of Molecular, Cellular and Developmental Biology , Yale University , New Haven , CT , USA.
authors.forename: Sidney
authors.initials: S
authors.lastname: Altman
authors.affiliation: a Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences , Novosibirsk , Russia and.
authors.forename: Valentin
authors.initials: V
authors.lastname: Vlassov
authors.affiliation: a Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences , Novosibirsk , Russia and.
authors.forename: Alya
authors.initials: A
authors.lastname: Venyaminova
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D003141:Communicable Diseases / Q000382:microbiology* / Q000821:virology*; D006801:Humans; D052156:SELEX Aptamer Technique / Q000379:methods; D014780:Viruses / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide
keywords: Antiviral and antimicrobial agents; SELEX; aptasensors; nucleic acid aptamers; pathogen detection