title: From steroid hormones to depressive states and senile dementias: New mechanistic, therapeutical and predictive approaches.
abstract: The discovery of "neurosteroids" leads to new descriptions and treatments of neuro-pathological pathologies. 3-β-methoxy-pregnenolone may be used to treat alterations of neuro-traumatisms and cerebral lesions associated with depressive states. Protein FKBP52 is involved in the dysfunction of the tau protein in Alzheimer's disease and senile dementias. In all cases, neuronal microtubules are involved in the mechanism of lesions and their repair.
authors.affiliation: Inserm U. 1195, Collège de France, fondation vivre longtemps, Mapreg, institut Professeur-Baulieu, université Paris-Sud, bâtiment Gregory-Pincus, secteur Marron, 80, rue du Général-Leclerc, 94276 Le Kremlin-Bicêtre cedex, France. Electronic address: etienne.baulieu@inserm.fr.
authors.forename: Étienne-Émile
authors.initials: ÉÉ
authors.lastname: Baulieu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000503:physiopathology*; D000818:Animals; D003704:Dementia / Q000188:drug therapy / Q000503:physiopathology*; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D011284:Pregnenolone / Q000031:analogs & derivatives / Q000494:pharmacology; D022021:Tacrolimus Binding Proteins / Q000378:metabolism
chemical_list: C510148:3beta-methoxypregnenolone; D018377:Neurotransmitter Agents; D011284:Pregnenolone; D022021:Tacrolimus Binding Proteins; C403485:tacrolimus binding protein 4
keywords: Alzheimer disease; Antidepressant medication; FKBP52 protein; MAP4343; Maladie d’Alzheimer; Microtubules; Médications antidépresseurs; Neurosteroids; Neurostéroïdes; Protéine FKBP52