title: Microscopic polyangiitis associated with pleuropericarditis, pulmonary embolism and pulmonary hemorrhage as a complication of silicosis.
abstract: Silica (silicon dioxide) occupational exposure has been linked to both pulmonary and extra-pulmonary toxicity. Silicosis is the major pulmonary toxicity, which has also been associated with the development of collagen-vascular disease and with anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis, especially perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA). The most common pulmonary manifestations of microscopic polyangitis (MPA) are interstitial fibrosis and alveolar hemorrhage. We describe a patient who had unusual presentation of microscopic polyangitis, characterized by lung hemorrhage, rapidly progressive glomerulonephritis, pleuropericarditis and pulmonary embolism that was associated with a history of silica exposure and radiologic evidence for silicosis.
authors.affiliation: McGill University, Montreal General Hospital, D7.201, Montreal, Quebec H3G 1A4, Canada.
authors.forename: Amjad
authors.initials: A
authors.lastname: Al-Rajhi
authors.affiliation: Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec H3A 2B4, Canada.
authors.forename: Elisa Ferreira
authors.initials: EF
authors.lastname: Brega
authors.affiliation: McGill University Health Centre, McGill University, Montreal General Hospital, D7.201, Montreal, Quebec H3G 1A4, Canada.
authors.forename: Neil C
authors.initials: NC
authors.lastname: Colman
keywords: ANCA; Microscopic polyangitis; Occupational lung disease; Silicosis; Vasculitis