title: Bioinformatics of antimicrobial resistance in the age of molecular epidemiology.
abstract: Antimicrobial resistance is a global health challenge and has an evolutionary trajectory ranging from proto-resistance in the environment to untreatable clinical pathogens. Resistance is not static, as pathogenic strains can move among patient populations and individual resistance genes can move among pathogens. Effective treatment of resistant infections, antimicrobial stewardship, and new drug discovery increasingly rely upon genotype information, powered by decreasing costs of DNA sequencing. These new approaches will require advances in microbial informatics, particularly in development of reference databases of molecular determinants such as our Comprehensive Antibiotic Resistance Database and clinical metadata, new algorithms for prediction of resistome and resistance phenotype from genotype, and new protocols for global collection and sharing of high-throughput molecular epidemiology data.
authors.affiliation: M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1. Electronic address: mcarthua@mcmaster.ca.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: McArthur
authors.affiliation: M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Gerard D
authors.initials: GD
authors.lastname: Wright
mesh_terms: D001419:Bacteria / Q000187:drug effects* / Q000235:genetics*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D019295:Computational Biology; D030541:Databases, Genetic; D055808:Drug Discovery; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005838:Genotype; D006801:Humans; D033181:Information Dissemination; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology / Q000379:methods*; D010641:Phenotype; D017422:Sequence Analysis, DNA