title: The role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive rats.
abstract: This study investigated the cardiovascular effects of nesfatin-1 in normotensive rats and animals subjected to hypotensive hemorrhage. Hemorrhagic hypotension was induced by withdrawal 2 mL blood/100 g body weight over a period of 10 min. Acute hemorrhage led to a severe and long-lasting decrease in mean arterial pressure (MAP) and heart rate (HR). Intracerebroventricularly (i.c.v.) administered nesfatin-1 (100 pmol) increased MAP in both normotensive and hemorrhaged rats. Nesfatin-1 also caused bradycardia in normotensive and tachycardia in hemorrhaged rats. Centrally injected nesfatin-1 (100 pmol, i.c.v.) also increased plasma catecholamine, vasopressin and renin concentrations in control animals and potentiated the rise in all three cardiovascular mediators produced by hemorrhage. These findings indicate that centrally administered nesfatin-1 causes a pressor response in conscious normotensive and hemorrhaged rats and suggest that enhanced sympathetic activity and elevated vasopressin and renin concentrations mediate the cardiovascular effects of the peptide.
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, Uludag University, Bursa 16059, Turkey.
authors.forename: Mustafa Sertac
authors.initials: MS
authors.lastname: Yilmaz
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.
authors.forename: Burcin
authors.initials: B
authors.lastname: Altinbas
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.
authors.forename: Gokcen
authors.initials: G
authors.lastname: Guvenc
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.
authors.forename: Leman Gizem
authors.initials: LG
authors.lastname: Erkan
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Avsar
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, Uludag University, Bursa 16059, Turkey.
authors.forename: Vahide
authors.initials: V
authors.lastname: Savci
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.
authors.forename: Duygu Udum
authors.initials: DU
authors.lastname: Kucuksen
authors.affiliation: Department of Anatomy, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Arican
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey. Electronic address: muraty@uludag.edu.tr.
authors.forename: Murat
authors.initials: M
authors.lastname: Yalcin
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001919:Bradycardia / Q000503:physiopathology; D002135:Calcium-Binding Proteins / Q000008:administration & dosage*; D002395:Catecholamines / Q000097:blood; D002491:Central Nervous System Agents / Q000008:administration & dosage*; D004268:DNA-Binding Proteins / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006470:Hemorrhage / Q000150:complications / Q000503:physiopathology; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D009419:Nerve Tissue Proteins / Q000008:administration & dosage*; D000080866:Nucleobindins; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood
chemical_list: D002135:Calcium-Binding Proteins; D002395:Catecholamines; D002491:Central Nervous System Agents; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C000630652:Nucb1 protein, rat; D000080866:Nucleobindins; D014667:Vasopressins; D012083:Renin
keywords: Catecholamine; Heart rate; Hemorrhagic shock; Mean arterial pressure; Nesfatin-1; Renin; Vasopressin