title: Dermatoglyphics and Reproductive Risk in a Family with Robertsonian Translocation 14q;21q.
abstract: OBJECTIVE
  The present study is carried out to evaluate the risk of giving birth to children with Down syndrome in a family with Robertsonian translocation 14q;21q, and to find the dermatoglyphic changes present in carriers of this translocation.
  
  
  METHODS
  Cytogenetics diagnosis has been made according to Moorhead and Seabright method, while the analysis of prints (dermatoglyphics analysis) was made with the Cummins and Midlo method.
  
  
  RESULTS
  Cytogenetic diagnosis has been made in a couple who suffered the spontaneous miscarriages and children with Down syndrome. Robertsonian translocation between chromosomes 14 and 21 (45, XX, der (14; 21) (q10; q10)) was found in a female partner who had four pregnancies, in two of which was found fetus karyotype with trisomy in chromosome 21 and pregnancies were terminated. The outcome of fourth pregnancy was twin birth, one of them with normal karyotype and another with Down syndrome due to Robertsonian translocation inherited by mother side. Specific dermatoglyphics traits are found in the child carrying Down syndrome, whereas several traits of dermatoglyphics characteristic of Down syndrome have been displayed among the silent carriers of Robertsonian translocation 14q;21q.
  
  
  CONCLUSIONS
  Robertsonian translocation found in female partner was the cause of spontaneous miscarriages, of giving birth to a child with Down syndrome, and of trisomy of chromosome 21 due to translocation in two pregnancies.
authors.affiliation: Obstetrics and Gynecology Clinic, University Clinical Centre of Kosova, Prishtina, Kosova.
authors.forename: Selim
authors.initials: S
authors.lastname: Kolgeci
authors.affiliation: Pediatric Clinic, University Clinical Centre of Kosova, Prishtina, Kosova.
authors.forename: Jehona
authors.initials: J
authors.lastname: Kolgeci
authors.affiliation: Pediatric Clinic, University Clinical Centre of Kosova, Prishtina, Kosova.
authors.forename: Mehmedali
authors.initials: M
authors.lastname: Azemi
authors.affiliation: Dermatovenerology Clinic, University Clinical Centre of Kosova, Prishtina, Kosova.
authors.forename: Aferdita
authors.initials: A
authors.lastname: Daka
authors.affiliation: Department of Histology and Embryology, University Clinical Centre of Kosova, Prishtina, Kosova.
authors.forename: Ruke
authors.initials: R
authors.lastname: Shala-Beqiraj
authors.affiliation: Faculty of Medicine, University of Prishtina, Prishtina, Kosova.
authors.forename: Ilir
authors.initials: I
authors.lastname: Kurtishi
authors.affiliation: Faculty of Medicine, University of Prishtina, Prishtina, Kosova.
authors.forename: Mentor
authors.initials: M
authors.lastname: Sopjani
keywords: Dermatoglyphics; Down Syndrome; Robertsonian Translocation; Spontaneous Miscarriages