title: [Meta-analysis of the efficacy of cochlear implantation in deaf patients with inner ear malformation].
abstract: OBJECTIVE
  Assess and compare the clinical efficacy and safety of cochlear implantation in deaf patients with inner ear malformation and in the ones with normal inner ear structure, so that to clarify whether it is effective to restore hearing for the deaf patients with inner ear malformation.
  
  
  METHODS
  The literature with relevant key words were retrieved in the databases including PubMed, YZ365. com, WANFANG data, CMJD, CHKD and CNKI with language limited to Chinese and English. Extracted data included author, year of publication, diagnosis, treatment, et al. The clinical efficacy of cochlear implantation was assessed by the complications, electrode impedance, behavior T-level, hearing abilities and speech discrimination. Meta-analysis was performed using random or fixed effects model according to the heterogeneity of data.
  
  
  RESULTS
  There were 11 randomized control studies involving 655 patients included in this study. There was no statistically significant difference among the deaf patients in mixed inner ear-malformation group, Mondini group and large vestibular aqueduct syndrome group in the aspects of postoperative complications, electrode impedance, behavior T-level, hearing abilities and speech discrimination.
  
  
  CONCLUSIONS
  Cochlear implantation could be the way of treatment and rehabilitation for deaf patients with inner ear malformation. Further controlled studies with longer follow-up periods and more multiracial cases included may help to evaluate the efficacy of cochlear implantation for deaf patients with inner ear malformation more reliably.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Xu
authors.forename: Suoqiang
authors.initials: S
authors.lastname: Zhai
authors.forename: Dongyi
authors.initials: D
authors.lastname: Han
authors.forename: Shiming
authors.initials: S
authors.lastname: Yang
authors.forename: Weidong
authors.initials: W
authors.lastname: Shen
mesh_terms: D019929:Cochlear Implantation; D007758:Ear, Inner / Q000002:abnormalities*; D017097:Electric Impedance; D004566:Electrodes; D006309:Hearing; D034381:Hearing Loss / Q000628:therapy*; D006801:Humans; D011183:Postoperative Complications; D016032:Randomized Controlled Trials as Topic; D013067:Speech Perception