title: Acute myeloid leukaemia with t(8;21)(q22;q22.3) and loss of the X chromosome.
abstract: Cytogenetic abnormalities occur in approximately 60% of newly diagnosed patients with acute myeloid leukaemia (AML) and are useful in the risk stratification of AML. Translocation between chromosomes 8 and 21-t(8;21)-(q22;q22.3), which carries a favourable prognosis, is found in approximately 5% to 10% of all patients with AML. Additional chromosomal abnormalities have been described in patients with AML with t(8;21), which may impact on the favourable prognosis. We report a patient who had AML with t(8;21)(q22;q22.3) and loss of the X chromosome.
authors.affiliation: Department of Haematology, Launceston General Hospital, Launceston, Tasmania, Australia.
authors.forename: Muhajir
authors.initials: M
authors.lastname: Mohamed
authors.affiliation: Department of Cytogenetics, Royal Hobart Hospital, Hobart, Tasmania, Australia.
authors.forename: Karen
authors.initials: K
authors.lastname: Dun
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D041321:Chromosomes, Human, X; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D009006:Monosomy; D011379:Prognosis; D014178:Translocation, Genetic