title: Treatment strategies in early-stage oropharyngeal squamous cell carcinoma: a French national survey.
abstract: The objective of the study is to perform a national survey of practices in early-stage squamous cell carcinoma (SCC) of the oropharynx (base of tongue and tonsils) targeting surgical and non-surgical procedures in France. A questionnaire concerning practices in surgery, radiotherapy, HPV screening, and two clinical cases were sent to all centers participating in the French Head and Neck Oncology Society, and to public hospitals listed as authorized to treat head and neck cancer according to the French National Cancer Institute (INCa). Sixty-four teams comprising almost all the University Hospitals and most of the Comprehensive Cancer Centers completed the survey questionnaire and responded to the clinical cases. Surgical and radiotherapy strategies were used in similar measure for early-stage SCC of the base of the tongue while tonsil lesions were mainly treated with surgery. The main arguments were disease control for the teams offering patients surgery, and functional results for those offering radiotherapy. However, concomitant chemoradiotherapy was chosen more frequently than radiotherapy alone in early-stage SCC of the base of tongue. Age and tobacco-alcohol addiction were decisive criteria in decision making for the majority of the teams. French oncology teams offered surgical and radiotherapy strategies in similar measure to treat early-stage SCC of the oropharynx (base of tongue and tonsils) as well as a high rate of multimodality therapy. Decision making was guided by the desire to achieve oncologic results adapted to the patient and his age, as well as functional preservation taking into account life expectancy.
authors.affiliation: Département de Cancérologie Cervico-Faciale, Gustave Roussy, 94805, Villejuif, France. Philippe.gorphe@gustaveroussy.fr.
authors.forename: Philippe
authors.identifier: http://orcid.org/0000-0001-7604-4964
authors.initials: P
authors.lastname: Gorphe
authors.affiliation: Département de Radiothérapie, Gustave Roussy, 94805, Villejuif, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Blanchard
authors.affiliation: Département d'ORL et Chirurgie Cervico-Faciale, CHU Bretonneau, 2 boulevard Tonnellé, 37000, Tours, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Morinière
authors.affiliation: Service d'ORL et Chirurgie Cervico-Faciale, CHU La Timone, Aix Marseille Université, 264 rue Saint Pierre, 13385, Marseille Cedex 05, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fakhry
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D001918:Brachytherapy / Q000706:statistics & numerical data; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery* / Q000821:virology; D059248:Chemoradiotherapy; D003657:Decision Making; D005602:France; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data; D065287:Robotic Surgical Procedures / Q000706:statistics & numerical data; D012907:Smoking / Q000009:adverse effects; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data; D014062:Tongue Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000821:virology; D014067:Tonsillar Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000821:virology
keywords: Cancer treatment; Human papillomavirus; Intensity-modulated radiotherapy treatment; National survey; Oropharynx squamous cell carcinoma; Transoral robotic surgery