title: Hoffmann's disease: MR imaging of hypothyroid myopathy.
abstract: Hoffmann's syndrome is a hypothyroid myopathy presenting as muscle stiffness and hypertrophy. It is a rare complication of hypothyroidism. MRI features of this syndrome have seldom been described in the literature. We present a case of Hoffmann's syndrome in a 34-year-old man who underwent lower extremity contrast-enhanced MRI. MRI can demonstrate the hypertrophic configuration, T2 hyperintensity, and enhancement of the involved muscles in Hoffmann's syndrome. Along with clinical, laboratory, and electromyography findings, MRI may be helpful in distinguishing between inflammatory myopathy, myonecrosis, subacute muscle denervation, and infectious myositis.
authors.affiliation: Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, 126-1, 5-ga Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea.
authors.forename: Jeewon
authors.initials: J
authors.lastname: Chung
authors.affiliation: Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, 126-1, 5-ga Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea. glassesik@gmail.com.
authors.forename: Kyung-Sik
authors.initials: KS
authors.lastname: Ahn
authors.affiliation: Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, 126-1, 5-ga Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea.
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Kang
authors.affiliation: Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Suk-Joo
authors.initials: SJ
authors.lastname: Hong
authors.affiliation: Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Gyeonggi-do, Korea.
authors.forename: Beak Hyun
authors.initials: BH
authors.lastname: Kim
mesh_terms: D000328:Adult; D003287:Contrast Media; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D007089:Image Enhancement; D007866:Leg / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009220:Myositis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D013577:Syndrome; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D003287:Contrast Media; D013974:Thyroxine
keywords: Hoffmann’s syndrome; Hypothyroidism; Magnetic resonance imaging; Myopathy