title: Dysfunction of Neurovascular/Metabolic Coupling in Chronic Focal Epilepsy.
abstract: OBJECTIVE
  We aim to evaluate the mechanisms underlying the neurovascular/metabolic coupling in the epileptogenic cortices of rats with chronic focal epilepsy.
  
  
  METHODS
  We performed and analyzed intracranial recordings obtained from the seizure-onset zones during ictal periods on epileptic rats, and then, used these data to fit a metabolically coupled balloon model. Normal rats undergoing forepaw stimulation were used as control.
  
  
  RESULTS
  We found a significant higher contribution from high local field potential frequency bands to the cerebral blood flow (CBF) responses in the epileptogenic cortices during ictal neuronal activities. The hemodynamic responses associated with ictal activities were distance-dependent with regard to the seizure focus, though varied in profiles from those obtained from acute seizure models. Parameters linking the CBF and relative concentration of deoxyhemoglobin to neuronal activity in the biophysical model were significantly different between epileptic and normal rats.
  
  
  CONCLUSIONS
  We found that the coefficient associated with the strength of the functional hyperemic response was significantly larger in the epileptogenic cortices, and changes in hemoglobin concentration associated with ictal activity reflected the existence of a significantly higher baseline for oxygen metabolism in the epileptogenic cortices.
  
  
  CONCLUSIONS
  Introducing methods to estimate these physiological parameters would enhance our understanding of the neurovascular/metabolic coupling in epileptic brains and improve the localization accuracy on irritative zones and seizure-onset zones through neuroimaging techniques.
authors.forename: Yinchen
authors.initials: Y
authors.lastname: Song
authors.forename: Rafael A
authors.initials: RA
authors.lastname: Torres
authors.forename: Sarahy
authors.initials: S
authors.lastname: Garcia
authors.forename: Yisel
authors.initials: Y
authors.lastname: Frometa
authors.forename: Jihye
authors.initials: J
authors.lastname: Bae
authors.forename: Abhay
authors.initials: A
authors.lastname: Deshmukh
authors.forename: Wei-Chiang
authors.initials: WC
authors.lastname: Lin
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Riera
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D004828:Epilepsies, Partial / Q000503:physiopathology*; D008297:Male; D008954:Models, Biological; D010101:Oxygen Consumption / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar