title: Enantioselective ortho-C-H cross-coupling of diarylmethylamines with organoborons.
abstract: The commonly used para-nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the CH activation of amines for the first time. An enantioselective ortho-CH cross-coupling between nosyl-protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono-N-protected amino acid (MPAA) ligands as a promoter.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Brian N
authors.initials: BN
authors.lastname: Laforteza
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Kelvin S L
authors.initials: KS
authors.lastname: Chan
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA). yu200@scripps.edu.
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008744:Methylamines / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001896:Boron Compounds; D008744:Methylamines; D009930:Organic Chemicals
keywords: CH activation; CH coupling; amino acid ligands; enantioselective catalysis; palladium