title: Formation of C(sp(2))-boronate esters by borylative cyclization of alkynes using BCl3.
abstract: BCl3 is an inexpensive electrophile which induces the borylative cyclization of a wide range of substituted alkynes to regioselectively form polycycles containing synthetically versatile C(sp(2) )boronate esters. It proceeds rapidly, with good yields and is compatible with a range of functional groups and substitution patterns. Intermolecular 1,2-carboboration of alkynes is also achieved using BCl3 to generate trisubstituted vinyl boronate esters.
authors.affiliation: School of Chemistry, University of Manchester, Manchester, M13 9PL (UK).
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Warner
authors.affiliation: School of Chemistry, University of Manchester, Manchester, M13 9PL (UK).
authors.forename: James R
authors.initials: JR
authors.lastname: Lawson
authors.affiliation: School of Chemistry, University of Manchester, Manchester, M13 9PL (UK).
authors.forename: Valerio
authors.initials: V
authors.lastname: Fasano
authors.affiliation: School of Chemistry, University of Manchester, Manchester, M13 9PL (UK). Michael.ingleson@manchester.ac.uk.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ingleson
keywords: alkynes; boron; cyclizations; heterocycles; synthetic methods