title: Self-Assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery.
abstract: An ideal vector in gene therapy should exhibit high serum stability, excellent biocompatibility, a desired transfection efficacy and permeability into targeted tissues. Here, we describe a class of low-molecular-weight fluorodendrimers for efficient gene delivery. These materials self-assemble into uniform nanospheres and allow for efficient transfection at low charge ratios and very low DNA doses with minimal cytotoxicity. Our results demonstrate that these vectors combine the features of synthetic gene vectors such as liposomes and cationic polymers and present promising potential for clinical gene therapy.
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai (China).
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai (China).
authors.forename: Yitong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Changzheng Hospital, Department of Orthopedic Oncology, Shanghai (China).
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai (China).
authors.forename: Jingjing
authors.initials: J
authors.lastname: Hu
authors.affiliation: China Institute of Atomic Energy, Beijing (China).
authors.forename: Tianfu
authors.initials: T
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai (China).
authors.forename: Hongmei
authors.initials: H
authors.lastname: Liu
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai (China).
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai (China). yycheng@mail.ustc.edu.cn.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
keywords: dendrimers; fluorine; gene delivery; self-assembly