title: Individualised second line anti-tuberculous therapy for an extensively resistant pulmonary tuberculosis (XDR PTB) in East Malaysia.
abstract: Clinical experience with extensively Drug Resistant tuberculosis (XDR-TB) has not been reported in Malaysia before. We describe the clinical characteristics, risk factors, progress and therapeutic regimen for a healthcare worker with XDR-TB, who had failed therapy for multidrug resistant TB (MDR TB) in our institution. This case illustrates the risk of TB among healthcare workers in high TB-burden settings, the importance of obtaining upfront culture and susceptibility results in all new TB cases, the problem of acquired drug resistance developing during MDR-TB treatment, the challenges associated with XDR-TB treatment regimens, the value of surgical resection in refractory cases, and the major quality of life impact this disease can have on young, economically productive individuals.
authors.affiliation: Hospital Queen Elizabeth, Department of Respiratory, Kota Kinabalu, Sabah, Malaysia. redzwanrashid@gmail.com.
authors.forename: S R A
authors.initials: SR
authors.lastname: Muhammad Redzwan
authors.affiliation: Royal Darwin Hospital, Department of Medicine, Northern Territory, Australia.
authors.forename: A P
authors.initials: AP
authors.lastname: Ralph
authors.affiliation: Hospital Queen Elizabeth, Department of Respiratory, Kota Kinabalu, Sabah, Malaysia.
authors.forename: K K
authors.initials: KK
authors.lastname: Sivaraman Kannan
authors.affiliation: Hospital Queen Elizabeth, Department of Medicine, Infectious Disease Unit, Kota Kinabalu, Sabah, Malaysia.
authors.forename: T
authors.initials: T
authors.lastname: William