title: Irisin levels in the progression of diabetes in sedentary women.
abstract: BACKGROUND
  The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. However, studies ended up with controversial results. In the present study, we aimed to investigate irisin levels in sedentary women at different stages of prediabetes.
  
  
  METHODS
  We performed a cross-sectional analysis of circulating levels of irisin in 263 females similar for age and body mass index (BMI) and the groups included 52 normal glucose tolerance (NGT), 60 isolated impaired fasting glucose (IFG), 36 isolated impaired glucose tolerance (IGT), 65 both IFG and IGT and 50 type 2 diabetic patients. All patients were exercising less than 150 min/week.
  
  
  RESULTS
  Plasma irisin levels were significantly lower in IFG+IGT (2.86 ± 0.6 μg/mL, p: 0.019) and T2DM (2.83 ± 0,5 μg/mL, p: 0.005) patients compared to NGT (3.16 ± 0.3 μg/mL) patients. After age adjustment there was a negative correlation between irisin and BMI (r: -0.141; p: 0.031), postprandial glucose (PPG) (r: -0.142; p: 0.030), low density lipoprotein-cholesterol (LDL-C) (r: -0.138; p: 0.035) and triglyceride (TG) (r: -0.214; p: 0.001) and a positive correlation between irisin and high density lipoprotein-cholesterol (HDL-C) (r:.142; p: 0.030). After adjustment for age and BMI; PPG (r: -0. 137; p: 0.037), LDL-C (r: -0. 143; p: 0.029) and TG (r: -0.203; p: 0.002) were considered to correlate with irisin levels. Subgroup analysis revealed that TG levels were correlated with irisin levels in IFG (r: -0.347; p: 0.014) and IGT (r: -0.397; p: 0.030) patients.
  
  
  CONCLUSIONS
  In our cohort of sedentary women, irisin levels were lower in patients with IFG+IGT and with diabetes than in patients with NGT. There is no correlation between irisin levels and BMI. Irisin is a myokine decreasing gradually with the progression of glucose intolerance and T2DM and is not correlated with BMI in sedentary women.
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Endocrinology and Metabolic Diseases, Turkey. Electronic address: driffetdagdelen@yahoo.com.
authors.forename: Iffet Dağdelen
authors.initials: ID
authors.lastname: Duran
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Endocrinology and Metabolic Diseases, Turkey.
authors.forename: Neşe Ersöz
authors.initials: NE
authors.lastname: Gülçelik
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Endocrinology and Metabolic Diseases, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ünal
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Clinical Biochemistry, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topçuoğlu
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Clinical Biochemistry, Turkey.
authors.forename: Sevilay
authors.initials: S
authors.lastname: Sezer
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Endocrinology and Metabolic Diseases, Turkey.
authors.forename: Mazhar Müslüm
authors.initials: MM
authors.lastname: Tuna
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Endocrinology and Metabolic Diseases, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Endocrinology and Metabolic Diseases, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Güler
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D018450:Disease Progression; D005215:Fasting / Q000097:blood; D005260:Female; D005353:Fibronectins / Q000097:blood / Q000235:genetics*; D015870:Gene Expression; D018149:Glucose Intolerance; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C577593:FNDC5 protein, human; D005353:Fibronectins; D014280:Triglycerides
keywords: glucose intolerance; irisin; normal glucose tolerance