title: The adipokine preadipocyte factor-1 is downregulated in preeclampsia and expressed in placenta.
abstract: BACKGROUND
  Adipokines contribute to the development of preeclampsia (PE), a severe pregnancy complication which increases the future risk for cardiovascular and metabolic disease in both mother and newborn. Pre-adipocyte factor-1 (Pref-1) was recently introduced as a novel antiangiogenic and antiadipogenic adipokine.
  
  
  METHODS
  Pref-1 was quantified in patients with PE (n=51) and healthy pregnant controls (n=51) during pregnancy, as well as 6 months after delivery (study population 1). Furthermore, Pref-1 was investigated in the immediate peripartal period and the placenta in 40 healthy pregnant women undergoing elective cesarean section (study population 2).
  
  
  RESULTS
  In study population 1, median Pref-1 serum concentrations during pregnancy were significantly lower in women with PE (0.5 μg/l) as compared to healthy pregnant controls (0.7 μg/l) (p<0.001). Furthermore, Pref-1 serum concentrations were independently predicted by PE, leptin levels, and gestational age in this population. In both study populations, Pref-1 serum levels significantly decreased after delivery as compared to prepartal levels. Moreover, significant expression of Pref-1 was detected in placental tissue.
  
  
  CONCLUSIONS
  Maternal Pref-1 serum concentrations are significantly decreased in PE. The pathophysiological significance of this regulation needs to be studied in more detail in future experiments.
authors.affiliation: University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schrey
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address: Ulrike.Wurst@medizin.uni-leipzig.de.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Wurst
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebert
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.affiliation: Centre for Trophoblast Research, Medical School, Wayne State University, Detroit, MI, USA.
authors.forename: Sascha
authors.initials: S
authors.lastname: Drewlo
authors.affiliation: University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Stepan
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lössner
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Platz
authors.affiliation: University of Leipzig, Institute of Laboratory Medicine, 04103 Leipzig, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kratzsch
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D000328:Adult; D002135:Calcium-Binding Proteins; D002585:Cesarean Section; D005260:Female; D005865:Gestational Age; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis / Q000097:blood* / Q000378:metabolism; D020738:Leptin / Q000097:blood; D008565:Membrane Proteins / Q000096:biosynthesis / Q000097:blood* / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood / Q000473:pathology*; D011247:Pregnancy
chemical_list: D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D008565:Membrane Proteins
keywords: Adipogenesis; Cesarean section; Placenta; Preeclampsia; Pref-1