title: Two Pairs of Enantiomeric Alkaloid Dimers from Macleaya cordata.
abstract: Two pairs of enantiomeric alkaloid dimers, (±)-macleayins A (1) and B (2), representing a novel dimerization pattern of two different types of alkaloids via a C-C σ-bond, were isolated from the aerial parts of Macleaya cordata. The enantiomeric separation was achieved by chiral chromatography. Their structures and stereochemistry were determined by the analysis of extensive spectroscopic data, electronic circular dichroism calculation, and single-crystal X-ray diffraction data. (-)-Macleayin A exhibits modest cytotoxic activity against HL-60 cell line with the IC50 value of 3.51 μM.
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Sai
authors.forename: Da-Hong
authors.initials: DH
authors.lastname: Li
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Xue
authors.forename: Kai-Bo
authors.initials: KB
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
authors.affiliation: ‡Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, United States.
authors.forename: Yong-Kui
authors.initials: YK
authors.lastname: Jing
authors.forename: Zhan-Lin
authors.initials: ZL
authors.lastname: Li
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D028101:Papaveraceae / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; C000603262:macleayin A; C000603263:macleayin B