title: Usefulness of Magnetic Resonance Sialography for the Evaluation of Radioactive Iodine-Induced Sialadenitis.
abstract: OBJECTIVE
  Radioactive iodine (RAI) ablation therapy after thyroidectomy commonly leads to obstructive sialadenitis. Magnetic resonance (MR) sialography is an emerging imaging modality that enables morphological and functional changes to be evaluated. This study was conducted to investigate the usefulness of MR sialography for the evaluation of RAI sialadenitis. In addition, the authors evaluated the correlation of MR sialographic grading with symptom severity using a symptom questionnaire (SQ), and salivary gland (SG) functions as determined by salivary flow rates (SFRs) and salivary scintigraphy (SSG) parameters.
  
  
  METHODS
  Eighteen patients with RAI sialadenitis who underwent MR sialography imaging were retrospectively enrolled. Subjective symptom scores were assessed and objective SG functions were evaluated. MR sialographic characteristics were analyzed and correlations between MR sialographic findings and clinicopathologic data, SQ, SFRs, and SSG parameters were investigated.
  
  
  RESULTS
  MR sialography demonstrated diagnostic findings of ductal stenosis and sialectasis, non-visualized ducts, and glandular atrophy mainly involving parotid glands. A significant correlation was found between obstructive symptom scores and ductal stenosis and sialectasis grades (both p < 0.05). Degrees of ductal stenosis and sialectasis were significantly correlated with SSG excretory variables [time from stimulation to minimum count (t min) and maximum secretion; all p < 0.05]. Significant linear correlations were found between duct nonvisualization and uptake variables [uptake ratio (UR) and maximum accumulation (MA); both p < 0.05]. Glandular volumes were also significantly correlated with UR and MA (both p < 0.05).
  
  
  CONCLUSIONS
  MR sialography images are useful for evaluating RAI sialadenitis, and its findings are in accordance with disease severity. An MR sialographic grading system is suggested to describe the severity of obstructive sialadenitis and SG dysfunction.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: Jeong-Seok
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: Hyun-Gon
authors.initials: HG
authors.lastname: Lim
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: Young-Mo
authors.initials: YM
authors.lastname: Kim
authors.affiliation: Department of Radiology, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: Myung Kwan
authors.initials: MK
authors.lastname: Lim
authors.affiliation: Department of Radiology, Inha University School of Medicine, Incheon, Republic of Korea. leehy@inha.ac.kr.
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea. jylim@inha.ac.kr.
authors.forename: Jae-Yol
authors.initials: JY
authors.lastname: Lim
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012793:Sialadenitis / Q000175:diagnosis* / Q000209:etiology; D012796:Sialography / Q000706:statistics & numerical data*; D014393:Tuberculosis, Oral / Q000175:diagnosis* / Q000209:etiology
chemical_list: D007457:Iodine Radioisotopes