title: Lipid parameters in patients with acute coronary syndromes versus stable coronary artery disease.
abstract: BACKGROUND
  Differences in lipid parameters between patients with acute coronary syndromes (ACS) and patients with stable coronary artery disease (CAD) are unclear and are addressed in this study.
  
  
  METHODS
  We enrolled 582 patients with angiographically proven stable CAD (of whom 26·9% had diabetes mellitus type 2 (T2DM)) and 182 patients with ACS (of whom 35·8% had T2DM).
  
  
  RESULTS
  HDL cholesterol and apolipoprotein A1 levels were significantly lower in patients with ACS than in patients with CAD (46 ± 16 mg/dL vs. 50 ± 16 mg/dL, P < 0·001, and 139 ± 30 mg/dL vs. 155 ± 31 mg/dL, P < 0·001, respectively). Analysis of covariance (ancova) adjusting for age, gender, smoking, BMI, statin therapy, alcohol use, hypertension and diabetic state confirmed an independent impact of ACS on HDL cholesterol and apolipoprotein A1 levels (F = 24·1; P < 0·001). In contrast, total cholesterol, LDL cholesterol, non-HDL cholesterol and apolipoprotein B levels did not differ significantly between patients with ACS and patients with stable CAD.
  
  
  CONCLUSIONS
  HDL cholesterol and apolipoprotein A1 levels are lower in patients with ACS than in patients with stable CAD.
authors.affiliation: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.|Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.|Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
authors.forename: Alexander
authors.initials: A
authors.lastname: Vonbank
authors.affiliation: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.|Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.|Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Saely
authors.affiliation: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.|Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.|Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
authors.forename: Philipp
authors.initials: P
authors.lastname: Rein
authors.affiliation: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.|Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.|Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.|Drexel University College of Medicine, Philadelphia, PA, USA.
authors.forename: Heinz
authors.initials: H
authors.lastname: Drexel
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000188:drug therapy; D000368:Aged; D000704:Analysis of Variance; D016632:Apolipoprotein A-I / Q000378:metabolism; D001055:Apolipoproteins B / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000097:blood; D006973:Hypertension / Q000097:blood; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D014280:Triglycerides / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014280:Triglycerides
keywords: Acute coronary syndrome; HDL cholesterol; apolipoprotein; coronary artery disease; lipid parameters; type 2 diabetes