title: Prognostic value of long non-coding RNA MALAT1 in cancer patients.
abstract: Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) was identified to be the first long non-coding RNA as a biomarker of independent prognostic value for early stage non-small cell lung cancer patient survival. In recent years, the association between upregulated tissue MALAT1 level and incidence of various cancers including bladder cancer, colorectal cancer, and renal cancer has been widely discussed. The aim of our present study was to assess the potential prognostic value of MALAT1 in various human cancers. PubMed, Embase, Ovid, and Cochrane Library databases were systematically searched, and eligible studies evaluating the prognostic value of MALAT1 in various cancers were included. Finally, 11 studies encompassing 1216 participants reporting with sufficient data were enrolled in the current meta-analysis. The pooled hazard ratio (HR) was 2.05 (95 % confidence interval (CI) 1.64-2.55, p < 0.01) for overall survival (OS) and 2.66 (95 % CI 1.86-3.80, p < 0.01) for disease-free survival (DFS). In conclusion, high tissue MALAT1 level was associated with an inferior clinical outcome in various cancers, suggesting that MALAT1 might serve as a potential prognostic biomarker for various cancers.
authors.affiliation: Department of Toxicology, School of Public Health, Zhejiang University, 866 Yuhangtang Road, Hangzhou, People's Republic of China. georgewuer@126.com.|Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, 866 Yuhangtang Road, Hangzhou, People's Republic of China. georgewuer@126.com.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Toxicology, School of Public Health, Zhejiang University, 866 Yuhangtang Road, Hangzhou, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Toxicology, School of Public Health, Zhejiang University, 866 Yuhangtang Road, Hangzhou, People's Republic of China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Xu
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pathology, Medical School, Zhejiang University, 866 Yuhangtang Road, Hangzhou, People's Republic of China.
authors.forename: Honghe
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Toxicology, School of Public Health, Zhejiang University, 866 Yuhangtang Road, Hangzhou, People's Republic of China. dxia@zju.edu.cn.
authors.forename: Dajing
authors.initials: D
authors.lastname: Xia
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models; D062085:RNA, Long Noncoding / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C557041:MALAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding
keywords: Cancer; Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1); Prognostic value