title: Improvement of digestive complaints in women with severe colorectal endometriosis benefiting from continuous amenorrhoea triggered by triptorelin. A prospective pilot study.
abstract: OBJECTIVE
  To assess the impact of therapeutic amenorrhoea triggered by triptorelin in the digestive complaints of women with deep endometriosis infiltrating the rectum.
  
  
  METHODS
  Prospective series of consecutive patients with deep endometriosis of the rectum enrolled over a period of 17 consecutive months.
  
  
  METHODS
  University tertiary referral center.
  
  
  METHODS
  Seventy patients.
  
  
  METHODS
  Medical therapy (triptorelin 11.25 mg and add-back therapy using estradiol) administered for 3.4±1.8months before surgery.
  
  
  METHODS
  Gastrointestinal standardised questionnaires before beginning medical treatment and the day before surgery.
  
  
  RESULTS
  The most frequent digestive complaints at baseline were: defecation pain in 77.1% of patients, bloating in 60%, diarrhoea in 54.3% and constipation in 50%. The largest diameter of the rectal area infiltrated by the disease was <1cm in 12.2% of women, 1 to 2.9 cm in 34.3% and ≥3cm in 51.4%. Multiple colorectal nodules were found in 32.9%. Medical treatment led to disappearance of cyclic defecation pain in 78.6%, dyschesia in 58.3%, diarrhoea in 58.3% and bloating in 50%. Relieving digestive complaints was not significantly related to either length of triptorelin administration or size of rectal infiltration by deep endometriosis.
  
  
  CONCLUSIONS
  Therapeutic amenorrhoea averaging 3 months allowed complete improvement of various cyclic digestive complaints in more than half of patients. In selected patients, continuous therapeutic amenorrhoea could compensate for the lack of complete resection of deep infiltrating endometriosis of the rectum, when this latter is likely to result in a high rate of postoperative morbidity.
authors.affiliation: Department of gynecology and obstetrics, Rouen university hospital, Rouen, France; Research group 4308 "spermatogenesis and gamete quality", IHU Rouen Normandy, IFRMP23, reproductive biology laboratory, Rouen university hospital, Rouen, France. Electronic address: horace.roman@gmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Roman
authors.affiliation: Department of gynecology and obstetrics, Rouen university hospital, Rouen, France.
authors.forename: M
authors.initials: M
authors.lastname: Saint Ghislain
authors.affiliation: Department of gynecology and obstetrics, Rouen university hospital, Rouen, France.
authors.forename: M
authors.initials: M
authors.lastname: Milles
authors.affiliation: Department of gynecology and obstetrics, Rouen university hospital, Rouen, France.
authors.forename: N
authors.initials: N
authors.lastname: Marty
authors.affiliation: Department of gynecology and obstetrics, Rouen university hospital, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Hennetier
authors.affiliation: Department of gynecology and obstetrics, Rouen university hospital, Rouen, France.
authors.forename: S
authors.initials: S
authors.lastname: Moatassim
authors.affiliation: Department of gynecology and obstetrics, Rouen university hospital, Rouen, France.
authors.forename: E
authors.initials: E
authors.lastname: Desnyder
authors.affiliation: Department of gynecology and obstetrics, Rouen university hospital, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Abo
mesh_terms: D000568:Amenorrhea / Q000139:chemically induced*; D003108:Colonic Diseases / Q000150:complications*; D004066:Digestive System Diseases / Q000188:drug therapy* / Q000209:etiology; D004715:Endometriosis / Q000150:complications*; D005260:Female; D006801:Humans; D008186:Luteolytic Agents; D010146:Pain; D011446:Prospective Studies; D012002:Rectal Diseases / Q000150:complications*; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
chemical_list: D008186:Luteolytic Agents; D017329:Triptorelin Pamoate
keywords: Agonistes de la gonadotropin releasing hormone; Aménorrhée; Colorectal endometriosis; Deep endometriosis; Endométriose colorectale; Endométriose profonde; Gonadotropin releasing hormone analogues; Medical treatment; Traitement médical; Triptorelin; Triptoréline