title: Disturbed spontaneous brain activity pattern in patients with primary angle-closure glaucoma using amplitude of low-frequency fluctuation: a fMRI study.
abstract: OBJECTIVE
  The aim of this study is to use amplitude of low-frequency fluctuation (ALFF) as a method to explore the local features of spontaneous brain activity in patients with primary angle -closure glaucoma (PACG) and ALFFs relationship with the behavioral performances.
  
  
  METHODS
  A total of twenty one patients with PACG (eight males and 13 females), and twenty one healthy subjects (nine males and twelve females) closely matched in age, sex, and education, each underwent a resting-state functional magnetic resonance imaging scan. The ALFF method was used to assess the local features of spontaneous brain activity. The correlation analysis was used to explore the relationships between the observed mean ALFF signal values of the different areas in PACG patients and the thickness of the retinal nerve fiber layer (RNFL).
  
  
  RESULTS
  Compared with the healthy subjects, patients with PACG had significant lower ALFF areas in the left precentral gyrus, bilateral middle frontal gyrus, bilateral superior frontal gyrus, right precuneus, and right angular gyrus, and higher areas in the right precentral gyrus. In the PACG group, there were significant negative correlations between the mean ALFF signal value of the right middle frontal gyrus and the left mean RNFL thickness (r=-0.487, P=0.033), and between the mean ALFF signal value of the left middle frontal gyrus and the right mean RNFL thickness (r=-0.504, P=0.020).
  
  
  CONCLUSIONS
  PACG mainly involved in the dysfunction in the frontal lobe, which may reflect the underlying pathologic mechanism of PACG.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Zhong
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Zeng
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Fuqing
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Chong-Gang
authors.initials: CG
authors.lastname: Pei
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People's Republic of China.
authors.forename: Xi-Jian
authors.initials: XJ
authors.lastname: Dai
keywords: amplitude of low-frequency fluctuation; angle-closure glaucoma; functional magnetic resonance imaging; resting state; retinal nerve fiber layer; spontaneous activity