title: Hematological parameters can predict the extent of coronary artery disease in patients with end-stage renal disease.
abstract: OBJECTIVE
  Aside from traditional factors (e.g., diabetes, age, and hypertension), some hematological parameters, such as neutrophil-to-lymphocyte ratio (NLR), red blood cell distribution width (RDW), and mean platelet volume (MPV), have increasingly been reported as measures of systemic inflammation and atherosclerosis in patients with end-stage renal disease (ESRD). This study aimed to determine whether there is an association between these hematological parameters and the extent of coronary artery disease (CAD) in patients with ESRD.
  
  
  METHODS
  A total of 149 consecutive ESRD patients (66 % males) without established CAD were studied. NLR, RDW, and MPV values in all patients were calculated from the complete blood count before coronary angiography. Angiographic views were assessed by an experienced interventional cardiologist, and the extent of CAD was evaluated by the Gensini score. The patients were divided into quartiles of the Gensini score.
  
  
  RESULTS
  Age, time on dialysis, calcium-phosphorus product, C-reactive protein levels, NLR, and MPV were significantly different among the groups (all p < 0.05). The Gensini score was correlated with age, time on dialysis (both p < 0.001), NLR (p = 0.004), and C-reactive protein levels (p = 0.034) and inversely correlated with left ventricular ejection fraction (p = 0.023). Multivariate regression analysis showed that age (p = 0.001), time on dialysis (p < 0.001), NLR (p = 0.001), and MPV (p = 0.005) were independent predictors of the extent of CAD.
  
  
  CONCLUSIONS
  Aside from the well-known traditional factors, NLR and MPV are independent predictors of the extent of CAD in patients with ESRD.
authors.affiliation: Department of Nephrology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey. zeynepberki@yahoo.com.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Bal
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Bal
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Kaan
authors.initials: K
authors.lastname: Okyay
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Balcioglu
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Turgay
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Senem
authors.initials: S
authors.lastname: Hasirci
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Alp
authors.initials: A
authors.lastname: Aydinalp
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Yildirir
authors.affiliation: Department of Nephrology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Siren
authors.initials: S
authors.lastname: Sezer
authors.affiliation: Department of Cardiology, Baskent University School of Medicine, Fevzi Cakmak Caddesi 10. Sokak No: 45, 06490, Bahcelievler, Ankara, Turkey.
authors.forename: Haldun
authors.initials: H
authors.lastname: Muderrisoglu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000792:Angiography; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications; D018655:Lymphocyte Count; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009504:Neutrophils; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D002097:C-Reactive Protein
keywords: Coronary artery disease; End-stage renal disease; Mean platelet volume; Neutrophil-to-lymphocyte ratio