title: Corneal complications of vernal keratoconjunctivitis.
abstract: OBJECTIVE
  Vernal keratoconjunctivitis (VKC) is a severe bilateral chronic allergic inflammatory disease of the ocular surface. In most of the cases, the disease is limited to the tarsal conjunctiva and to the limbus. However, in the more severe cases, the cornea may be involved, leading to potentially sight threatening complications. Prompt recognition of these complications is crucial in the management of VKC, which is one of the most severe ocular allergic diseases.
  
  
  RESULTS
  A vicious cycle of inflammation occurs as a result of a set of reciprocal interactions between the conjunctiva and the cornea, which results in damage to the corneal epithelium and corneal stoma, and to the formation of shield ulcers and plaques, infectious keratitis, keratoconus, scarring, and limbal stem cell deficiency. These corneal complications can cause permanent decrease or loss of vision in children suffering from VKC.
  
  
  CONCLUSIONS
  Corneal complications in VKC are the result of an on-going process of uncontrolled inflammation. Proper recognition of the corneal complications in VKC is crucial, as most of these can be managed or prevented by a combination of medical and surgical measures.
authors.affiliation: Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Solomon
mesh_terms: D000818:Animals; D002450:Cell Communication; D002648:Child; D003228:Conjunctiva / Q000276:immunology*; D003233:Conjunctivitis, Allergic / Q000150:complications / Q000276:immunology*; D003315:Cornea / Q000276:immunology*; D003320:Corneal Ulcer / Q000209:etiology; D006801:Humans; D007634:Keratitis / Q000209:etiology; D007640:Keratoconus / Q000209:etiology; D016850:Limbus Corneae / Q000276:immunology*; D014785:Vision, Ocular