title: Quantitative assessment of pre-miR-218 rs11134527 polymorphism and cancer risk in Chinese population.
abstract: BACKGROUND
  Accumulated studies have evaluated the association of pre-miR-218 rs11134527 polymorphism with cancer risk in Chinese population. However, the results remain controversial.
  
  
  METHODS
  To derive a more precise and more comprehensive estimation of the relationship, six studies focused on Chinese population were included for the pooled analysis for pre-miR-218 rs11134527 polymorphism using odds ratios (ORs) with 95% confidence intervals (CIs).
  
  
  RESULTS
  Pre-miR-218 rs11134527 polymorphism was associated with cancer risk (G versus A, OR =0.93, 95% CI: 0.88-0.98; GG versus AG + AA, OR =0.88, 95% CI: 0.79-0.97; GG versus AA, OR =0.85, 95% CI: 0.76-0.96). In the stratified analysis by cancer type, the pre-miR-218 rs11134527 polymorphism was only associated with the risk of cervical cancer (G versus A, OR =0.90, 95% CI: 0.83-0.98; GG versus AG + AA, OR =0.80, 95% CI: 0.68-0.94; GG versus AA, OR =0.79, 95% CI: 0.66-0.94).
  
  
  CONCLUSIONS
  These findings suggest that the pre-miR-218 rs11134527 genetic polymorphism may decrease the susceptibility to cervical cancer, which needs to be verified or linked with functional studies.
authors.affiliation: Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, People's Republic of China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Nanjing Kingmed Clinical Laboratory Co., Ltd, Nanjing, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
keywords: cancer; meta-analysis; polymorphism; risk; single-nucleotide polymorphisms