title: Condensing chromosome condensation.
abstract: Mitotic chromosome condensation has fascinated biologists since Flemming's early illustrations of mitosis in the late nineteenth century. Now--130 years later--chromatid condensation is reconstituted in vitro with the minimum components. The results are remarkably and beautifully simple, requiring only core histones, three histone chaperones, topoisomerase II and condensin I.
authors.affiliation: Department of Biochemistry, 279 Campus Drive, Beckman Center B-409, Stanford, California 94305-5307, USA.
authors.forename: Jason C
authors.initials: JC
authors.lastname: Bell
authors.affiliation: Department of Biochemistry, 279 Campus Drive, Beckman Center B-409, Stanford, California 94305-5307, USA.
authors.forename: Aaron F
authors.initials: AF
authors.lastname: Straight
mesh_terms: D000818:Animals; D002842:Chromatids / Q000201:enzymology*; D042002:Chromatin Assembly and Disassembly; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008938:Mitosis; D018832:Molecular Chaperones / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D013094:Spermatozoa / Q000201:enzymology*; D029867:Xenopus Proteins / Q000378:metabolism*
chemical_list: D006657:Histones; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins; D029867:Xenopus Proteins