title: Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression.
abstract: To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for the selection of MSC donors could enhance the results of cell-based therapies.
authors.affiliation: Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada. ozge.kizilay@mail.mcgill.ca.
authors.forename: Ozge
authors.initials: O
authors.lastname: Kizilay Mancini
authors.affiliation: Division of Cardiothoracic Surgery and Surgical Research, Royal Victoria Hospital, McGill University Health Center, Montreal, QC, Canada. dshumtim@yahoo.ca.
authors.forename: Dominique
authors.initials: D
authors.lastname: Shum-Tim
authors.affiliation: Department of Physiology, McGill University, Montreal, QC, Canada. ursula.stochaj@mcgill.ca.
authors.forename: Ursula
authors.initials: U
authors.lastname: Stochaj
authors.affiliation: Department of Mathematics and Statistics, McGill University, Montreal, QC, Canada. jcorrea@math.mcgill.ca.
authors.forename: José A
authors.initials: JA
authors.lastname: Correa
authors.affiliation: Division of Rheumatology, Department of Medicine, McGill University, Montreal, QC, Canada. ines.colmegna@mcgill.ca.|Royal Victoria Hospital, McGill University Health Centre, 1001 Boulevard, Décarie, Montréal, Québec, H4A 3J1, Canada. ines.colmegna@mcgill.ca.
authors.forename: Inés
authors.initials: I
authors.lastname: Colmegna
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D000367:Age Factors; D000368:Aged; D050197:Atherosclerosis / Q000473:pathology*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D049109:Cell Proliferation; D002478:Cells, Cultured; D018920:Coculture Techniques; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D008875:Middle Aged; D012720:Severity of Illness Index