title: Neurology and psychiatry: waking up to opportunities of sleep. : State of the art and clinical/research priorities for the next decade.
abstract: In recent years, evidence has emerged for a bidirectional relationship between sleep and neurological and psychiatric disorders. First, sleep-wake disorders (SWDs) are very common and may be the first/main manifestation of underlying neurological and psychiatric disorders. Secondly, SWDs may represent an independent risk factor for neuropsychiatric morbidities. Thirdly, sleep-wake function (SWF) may influence the course and outcome of neurological and psychiatric disorders. This review summarizes the most important research and clinical findings in the fields of neuropsychiatric sleep and circadian research and medicine, and discusses the promise they bear for the next decade. The findings herein summarize discussions conducted in a workshop with 26 European experts in these fields, and formulate specific future priorities for clinical practice and translational research. More generally, the conclusion emerging from this workshop is the recognition of a tremendous opportunity offered by our knowledge of SWF and SWDs that has unfortunately not yet entered as an important key factor in clinical practice, particularly in Europe. Strengthening pre-graduate and postgraduate teaching, creating academic multidisciplinary sleep-wake centres and simplifying diagnostic approaches of SWDs coupled with targeted treatment strategies yield enormous clinical benefits for these diseases.
authors.affiliation: Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
authors.forename: C L
authors.initials: CL
authors.lastname: Bassetti
authors.affiliation: Division of Neuroscience, Sleep Disorders Centre, Università Vita-Salute San Raffaele, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ferini-Strambi
authors.affiliation: Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Brown
authors.affiliation: Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Adamantidis
authors.affiliation: Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Benedetti
authors.affiliation: Department of Developmental and Social Psychology, Sapienza University, Rome, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Bruni
authors.affiliation: Psychiatric University Clinic, Basel, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Cajochen
authors.affiliation: Division of Neurology, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: L
authors.initials: L
authors.lastname: Dolenc-Groselj
authors.affiliation: Department of Neurology, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ferri
authors.affiliation: Medical Psychology and Behavioural Neurobiology, Eberhard Karls Universität Tübingen, Tübingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Gais
authors.affiliation: Department of Paediatrics, Children's University Hospital, Zurich, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.affiliation: Sleep Centre, Klinik Barmelweid AG, Barmelweid, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Khatami
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands.|Sleep Wake Centre SEIN, Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Lammers
authors.affiliation: UMR 5292 CNRS/U1028 INSERM, Centre de Recherche en Neurosciences de Lyon (CRNL), Team "Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil", Université Claude Bernard Lyon I, Lyon, France.
authors.forename: P H
authors.initials: PH
authors.lastname: Luppi
authors.affiliation: Sleep and Epilepsy Centre, Neurocentre of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Manconi
authors.affiliation: Department of Clinical Psychology and Psychophysiology/Sleep Medicine, Centre for Mental Disorders, Freiburg University Medical Centre, Freiburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Nissen
authors.affiliation: Centre of Epilepsy Surgery 'C. Munari', Niguarda Hospital, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Nobili
authors.affiliation: UR2NF - Neuropsychology and Functional Neuroimaging Research Unit, CRCN - Centre de Recherches Cognition et Neurosciences and UNI - ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Peigneux
authors.affiliation: Center of Mental Health, Klinikum Ingolstadt, Ingolstadt, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Pollmächer
authors.affiliation: Institut für Pneumologie, Krankenhaus Bethanien gGmbH, Universität Witten/Herdecke, Solingen, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Randerath
authors.affiliation: Department of Clinical Psychology and Psychophysiology/Sleep Medicine, Centre for Mental Disorders, Freiburg University Medical Centre, Freiburg, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Riemann
authors.affiliation: Neurology Service, Hospital Clínic of Barcelona, Institut d'Investigació Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Santamaria
authors.affiliation: Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Schindler
authors.affiliation: Centre for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.|Centre for Investigation and Research in Sleep, Vaud University Hospital, Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Tafti
authors.affiliation: Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.|Departments of Integrative Neurophysiology and Medical Psychology, Center for Neurogenomics and Cognitive Research (CNCR), VU University and Medical Center, Amsterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Van Someren
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
authors.forename: T C
authors.initials: TC
authors.lastname: Wetter
mesh_terms: D035843:Biomedical Research / Q000639:trends*; D006801:Humans; D009462:Neurology / Q000639:trends*; D011570:Psychiatry / Q000639:trends*; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*
keywords: neurological disorders; neurology; psychiatric disorders; psychiatry; sleep; sleep research; sleep-wake disorders