title: The changing landscape of respiratory syncytial virus.
abstract: Recognition of the acute and chronic burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) sparked a wave of initiatives to develop preventive and therapeutic products against the pathogen in recent years. RSV is a leading cause of hospitalization in infants in industrialized and developing countries, has been causally linked to recurrent wheezing during childhood, associated with pediatric asthma, and is an important cause of mortality in the first months of life in the developing world. Significant changes in the epidemiology, clinical manifestations, and severe consequences of LRTI may emerge in the next decade with the advent of novel preventive strategies against RSV. This manuscript outlines some of these changes and discusses potential scenarios based on the current literature and experiences with other pathogens.
authors.affiliation: Vanderbilt Vaccine Center at Vanderbilt University, Nashville, TN, United States; Fundacion INFANT, Buenos Aires, Argentina. Electronic address: fernando.p.polack@vanderbilt.edu.
authors.forename: Fernando P
authors.initials: FP
authors.lastname: Polack
mesh_terms: D014943:Global Health; D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000473:pathology* / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification*; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000473:pathology* / Q000821:virology
keywords: Enhanced respiratory syncytial virus disease; Infant mortality; Pregnancy; Recurrent wheezing; Respiratory syncytial virus; Vaccines