title: The yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNA.
abstract: Hepatitis C virus (HCV) is an unusual RNA virus that has a striking capacity to persist for the remaining life of the host in the majority of infected individuals. In order to persist, HCV must balance viral RNA synthesis and decay in infected cells. In this Review, we focus on interactions between the positive-sense RNA genome of HCV and the host RNA-binding proteins and microRNAs, and describe how these interactions influence the competing processes of viral RNA synthesis and decay to achieve stable, long-term persistence of the viral genome. Furthermore, we discuss how these processes affect hepatitis C pathogenesis and therapeutic strategies against HCV.
authors.affiliation: 1] Lineberger Comprehensive Cancer Center, Division of Infectious Diseases, Department of Medicine and Department of Microbiology &Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27517-7292, USA. [2].
authors.forename: You
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1] Lineberger Comprehensive Cancer Center, Division of Infectious Diseases, Department of Medicine and Department of Microbiology &Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27517-7292, USA. [2].
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamane
authors.affiliation: 1] Lineberger Comprehensive Cancer Center, Division of Infectious Diseases, Department of Medicine and Department of Microbiology &Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27517-7292, USA. [2] Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Masaki
authors.affiliation: 1] Lineberger Comprehensive Cancer Center, Division of Infectious Diseases, Department of Medicine and Department of Microbiology &Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27517-7292, USA. [2] The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7292, USA.
authors.forename: Stanley M
authors.initials: SM
authors.lastname: Lemon
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D016174:Hepacivirus / Q000378:metabolism*; D006526:Hepatitis C / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D006801:Humans; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism*
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral