title: Stromal Cell-Derived Factor-1α Plays a Crucial Role Based on Neuroprotective Role in Neonatal Brain Injury in Rats.
abstract: Owing to progress in perinatal medicine, the survival of preterm newborns has markedly increased. However, the incidence of cerebral palsy has risen in association with increased preterm birth. Cerebral palsy is largely caused by cerebral hypoxic ischemia (HI), for which there are no effective medical treatments. We evaluated the effects of stromal cell-derived factor-1α (SDF-1α) on neonatal brain damage in rats. Left common carotid (LCC) arteries of seven-day-old Wistar rat pups were ligated, and animals were exposed to hypoxic gas to cause cerebral HI. Behavioral tests revealed that the memory and spatial perception abilities were disturbed in HI animals, and that SDF-1α treatment improved these cognitive functions. Motor coordination was also impaired after HI but was unimproved by SDF-1α treatment. SDF-1α reduced intracranial inflammation and induced cerebral remyelination, as indicated by the immunohistochemistry results. These data suggest that SDF-1α specifically influences spatial perception abilities in neonatal HI encephalopathy.
authors.affiliation: Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan. morimiki@m.ehime-u.ac.jp.
authors.forename: Miki
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan. keiichi@m.ehime-u.ac.jp.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Matsubara
authors.affiliation: Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan. takeyu@m.ehime-u.ac.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Matsubara
authors.affiliation: Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan. yuka.itani@gmail.com.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Uchikura
authors.affiliation: Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan. hashimoto.hisashi.mm@ehime-u.ac.jp.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hashimoto
authors.affiliation: Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan. fujioka@m.ehime-u.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Fujioka
authors.affiliation: Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan. matsugen@m.ehime-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D054377:Chemokine CXCL12 / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D054377:Chemokine CXCL12; D018696:Neuroprotective Agents
keywords: Rotarod test; TTC staining; hypoxic-ischemic encephalopathy; magnetic resonance imaging; morris water maze test; rat; stromal cell-derived factor-1α