title: Electrocatalytic boost up of epinephrine and its simultaneous resolution in the presence of serotonin and folic acid at poly(serine)/multi-walled carbon nanotubes composite modified electrode: A voltammetric study.
abstract: The present paper describes the new strategy for the development of nanosensor based on dropcasting of multi-walled carbon nanotubes (MWCNTs) followed by electropolymerization of serine (ser) onto the glassy carbon electrode (GCE). The developed nanocomposite sensor was abbreviated as poly(ser)/MWCNTs/GCE and was characterized by using electrochemical impedance spectroscopy (EIS) technique. The EIS results confirmed the fast electron transfer rate at the surface of poly(ser)/MWCNTs/GCE. The proposed sensor exhibited good catalytic activity towards the sensing of epinephrine (EP) individually and simultaneously in the presence of serotonin (5-HT) and folic acid (FA) in 0.1M phosphate buffer solution (PBS) at pH7.0. The limit of detection (LOD) and limit of quantification (LOQ) of EP was found to be 6×10(-7)M and 2×10(-6)M respectively. The fabricated sensor showed excellent precision and accuracy with a relative standard deviation (RSD) of 4.86%. The proposed composite sensor was effectively applied towards the determination of EP in human blood serum and pharmaceutical injection sample.
authors.affiliation: Electrochemical Research Laboratory, Department of Chemistry, SVU College of Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: P V
authors.initials: PV
authors.lastname: Narayana
authors.affiliation: Electrochemical Research Laboratory, Department of Chemistry, SVU College of Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: tmsreddysvu@gmail.com.
authors.forename: T
authors.initials: T
authors.lastname: Madhusudana Reddy
authors.affiliation: Electrochemical Research Laboratory, Department of Chemistry, SVU College of Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: P
authors.initials: P
authors.lastname: Gopal
authors.affiliation: Department of Psychiatry, Sri Devaraj Ur's Acedamy of Higher Education and Research (SDUAHER), Tamaka, Kolar, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Mohan Reddy
authors.affiliation: Department of Environmental Sciences, SVU College of Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Ramakrishna Naidu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods; D002384:Catalysis; D058266:Dielectric Spectroscopy / Q000379:methods; D055664:Electrochemical Techniques / Q000379:methods; D004566:Electrodes; D004837:Epinephrine / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D005898:Glass / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D053761:Nanocomposites / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D012694:Serine / Q000737:chemistry*; D012701:Serotonin / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D012701:Serotonin; D012694:Serine; D005492:Folic Acid; D004837:Epinephrine
keywords: Differential pulse voltammetry; Electrochemical impedance spectroscopy; Epinephrine; Multi-walled carbon nanotubes; Nanocomposite electrode; Simultaneous determination