title: [Analysis of age-period-cohort effect on breast cancer mortality in Brazil and regions].
abstract: OBJECTIVE
  To estimate the effect of age, period and birth cohort on mortality from breast cancer in Brazil and regions.
  
  
  METHODS
  Data on mortality from breast cancer were analyzed for women aged > 30 years in Brazil and regions from 1980 to 2009. The effect of age, period, and birth cohort was calculated by Poisson regression model using estimable functions: deviations, curvatures and drift through the Epi library of R statistical software version 3.2.1.
  
  
  RESULTS
  The mean mortality rate for the period was 22.3 per 100 000 women in Brazil. The highest rate was 32.4 deaths per 100 000 women in the South, and the lowest, 8.6 deaths per 100 000 women in the North. The analysis of birth cohorts showed a progressive increase in the risk of death in women born after the 1930s, except in the Southeast, where a decrease in relative risk was noted for this group.
  
  
  CONCLUSIONS
  The analyses revealed a reduction in the risk of death from breast cancer in Brazil and in most regions for birth cohorts starting in the 1930s, and an increased in the risk of death starting in the 1990s until the period from 2000 to 2005.
authors.affiliation: Escola de Enfermagem de Natal, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.
authors.forename: Karina Cardoso
authors.initials: KC
authors.lastname: Meira
authors.affiliation: Laboratório de Educação Profissional em Vigilância em Saúde, Escola Politécnica de Saúde Joaquim Venâncio, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil, raphael.guimaraes@fiocruz.br.
authors.forename: Raphael Mendonça
authors.initials: RM
authors.lastname: Guimarães
authors.affiliation: Programa de Pós-Graduação em Enfermagem na Saúde do Adulto, Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Juliano dos
authors.initials: Jd
authors.lastname: Santos
authors.affiliation: Instituto Nacional de Câncer, MS, Rio de Janeiro, RJ, Brasil.
authors.forename: Renata
authors.initials: R
authors.lastname: Cabrelli
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D001943:Breast Neoplasms / Q000401:mortality*; D005260:Female; D062306:Geography, Medical; D006801:Humans; D008875:Middle Aged; D009026:Mortality / Q000639:trends