title: [Challenges when improving surgical conditions by use of neuromuscular blockade].
abstract: Neuromuscular blockade (NMB) may pose a clinical dilemma between surgeons' requirements of muscle relaxation and the risk of residual blockade. This review has aimed at describing the challenges when using NMB for optimizing surgical conditions and reasons for inadequate relaxation despite use of NMB. Interdisciplinary collaboration, proper neuromuscular monitoring, knowledge on differences in pharmacodynamics and pharmacokinetics of NMB are essential factors when optimizing surgical conditions by use of NMB.
authors.affiliation: Anæstesiologisk Afdeling, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev. matias.vested.madsen@regionh.dk.
authors.forename: Sarah Isak
authors.initials: SI
authors.lastname: Julin
authors.forename: Emilie
authors.initials: E
authors.lastname: Øberg
authors.forename: Mona Ring
authors.initials: MR
authors.lastname: Gätke
authors.forename: Jacob
authors.initials: J
authors.lastname: Rosenberg
authors.forename: Matias Vested
authors.initials: MV
authors.lastname: Madsen
mesh_terms: D006801:Humans; D009126:Muscle Relaxation / Q000187:drug effects; D019148:Neuromuscular Blockade / Q000379:methods*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D061886:Neuromuscular Monitoring; D013514:Surgical Procedures, Operative; D013997:Time Factors
chemical_list: D009466:Neuromuscular Blocking Agents