title: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for First Relapse of Ovarian Cancer.
abstract: BACKGROUND
  To assess impact of surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients treated for a first relapse of ovarian cancer (FROC).
  
  
  METHODS
  Patients with a FROC treated with second-line chemotherapy, surgery and HIPEC were retrospectively included from 13 Institutions. Studied parameters were interval free between the end of initial treatment and the first relapse, second-line chemotherapy, peritoneal cancer index and completeness of surgery, HIPEC, mortality and morbidity, pathological results and survival.
  
  
  RESULTS
  From 2001 to 2010, 314 patients were included. The main strategy was secondary chemotherapy followed by surgery and HIPEC (269/314-85.6%). Mortality and morbidity rates were respectively 1% and 30.9%. Median follow-up was 50 months, 5-year overall survival was 38.0%, with no difference between platinum-sensitive or -resistant patients and 5-year disease-free survival was 14%.
  
  
  CONCLUSIONS
  HIPEC allows encouraging survival in the treatment of FROC, better in case of complete surgery, with acceptable mortality and morbidity rates.
authors.affiliation: Institut de Cancérologie de l' Ouest, Centre René Gauducheau, Saint-Herblain, France jean-marc.classe@ico.unicancer.fr.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Classe
authors.affiliation: Université Lyon 1, EMR 3738, Villeurbanne, France Hôpital Lyon Sud, Pierre Bénite, Pierre-Bénite Cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Glehen
authors.affiliation: Hospices Civils de Lyon, Pôle IMER, Unité de méthodologie en recherche clinique, Lyon, France Université de Lyon, RECIF, EAM Santé Individu Société, Lyon, France Université Lyon 1, Lyon, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Decullier
authors.affiliation: Centre Hospitalier L' Archet II, Nice, France.
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Bereder
authors.affiliation: Hopital Louis Mourier, Colombes, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Msika
authors.affiliation: Institut de Cancérologie de l' Ouest, Centre Paul Papin, Angers, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Lorimier
authors.affiliation: Hopital Nord, Saint-Priest-en-Jarez, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Abboud
authors.affiliation: Centre Léon Bérard, Laennec, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Meeus
authors.affiliation: IUCT Oncopole, Toulouse, France.
authors.forename: Gwenael
authors.initials: G
authors.lastname: Ferron
authors.affiliation: Centre Val d'Aurelle, Montpellier, France.
authors.forename: François
authors.initials: F
authors.lastname: Quenet
authors.affiliation: Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Marchal
authors.affiliation: Institut Gustave Roussy, Villejuif, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Gouy
authors.affiliation: Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Pomel
authors.affiliation: Hopital Lariboisiere, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Pocard
authors.affiliation: Institut Bergonie, Bordeaux, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Guyon
authors.affiliation: Université Lyon 1, EMR 3738, Villeurbanne, France.
authors.forename: Naoual
authors.initials: N
authors.lastname: Bakrin
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007274:Injections, Intraperitoneal; D008875:Middle Aged; D009017:Morbidity; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D012008:Recurrence; D055815:Young Adult
keywords: Ovarian cancer relapse; hyperthermic intra-peritoneal chemotherapy; secondary surgery