title: Determination of a N-Nitrosodimethylamine Precursor in Water Using Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry.
abstract: 1,1,5,5-Tetramethylcarbohydrazide (TMCH) is the main precursor of N-nitrosodimethylamine upon ozonation in the Yodo River basin, Japan. This study was performed to develop an analytical method for TMCH using solid-phase extraction with ultra-high performance liquid chromatography-tandem mass spectrometry. TMCH is hydrophilic and a tertiary amine derivative, so Oasis(®) MCX cartridges were used as solid-phase cartridges. The recoveries of TMCH in tap and river waters as well as secondary effluent from a sewage treatment plant ranged from 75 to 94%. The limit of quantification of TMCH was 4 ng L(-1). The source of TMCH in the Yodo River basin was found to be effluent from one sewage treatment plant. The concentrations were < 4 ng L(-1) in raw water from water purification plants in regions other than the Yodo River basin, indicating that TMCH was used specifically in the basin.
authors.affiliation: Department of Environmental Health, National Institute of Public Health.
authors.forename: Koji
authors.initials: K
authors.lastname: Kosaka
authors.forename: Mari
authors.initials: M
authors.lastname: Asami
authors.forename: Keiko
authors.initials: K
authors.lastname: Ohkubo
authors.forename: Michihiro
authors.initials: M
authors.lastname: Akiba
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004128:Dimethylnitrosamine / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D057230:Limit of Detection; D045483:Rivers / Q000737:chemistry; D012722:Sewage / Q000737:chemistry; D052616:Solid Phase Extraction; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014867:Water / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D012722:Sewage; D014874:Water Pollutants, Chemical; D014867:Water; D004128:Dimethylnitrosamine