title: CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder.
abstract: Gallbladder cancer is the most common biliary tract malignancy with the worst overall prognosis. CD109 is a co-receptor of TGF-β1 and suppresses TGF-β signaling. In this study, CD109 protein expression in three subtypes of gallbladder cancer was examined by immunohistochemistry on human tissue samples and tissue microarrays. We found that CD109 is specifically expressed in malignant squamous cells in squamous cell carcinomas (86.7%) and adenosquamous carcinomas (91.7%), but not in adenocarcinomas or normal gallbladder tissues. Thus, CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas.
authors.affiliation: Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, Shandong, 250014, China. dong.fengyun@163.com.
authors.forename: Fengyun
authors.initials: F
authors.lastname: Dong
authors.affiliation: Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, Shandong, 250014, China. 1751643663@qq.com.
authors.forename: Chuanfeng
authors.initials: C
authors.lastname: Lu
authors.affiliation: Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, Shandong, 250014, China. 1217064502@qq.com.
authors.forename: Xiaocui
authors.initials: X
authors.lastname: Chen
authors.affiliation: Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, Shandong, 250014, China. guoyuan@sdhospital.com.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, Shandong, 250014, China. ju.liu@sdu.edu.cn.
authors.forename: Ju
authors.initials: J
authors.lastname: Liu
mesh_terms: D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D018196:Carcinoma, Adenosquamous / Q000378:metabolism / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D058851:GPI-Linked Proteins / Q000032:analysis / Q000096:biosynthesis; D005706:Gallbladder Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009363:Neoplasm Proteins / Q000032:analysis / Q000096:biosynthesis*; D046888:Tissue Array Analysis
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C120523:CD109 protein, human; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins