title: Pruritus in Systemic Diseases: A Review of Etiological Factors and New Treatment Modalities.
abstract: Pruritus is the most frequently described symptom in dermatology and can significantly impair the patient's quality of life. In 10-50% of adults with persistent pruritus, it can be an important dermatologic clue for the presence of a significant underlying systemic disease such as renal insufficiency, cholestasis, hematologic disorder, or malignancy (Etter and Myers, 2002; Zirwas and Seraly, 2001). This review describes the presence of pruritus in different systemic diseases. It is quite important to discover the cause of pruritus for providing relief for the patients experiencing substantial morbidity caused by this condition.
authors.affiliation: Department of Dermatology, Okmeydanı Training and Research Hospital, 34384 Istanbul, Turkey.
authors.forename: Nagihan
authors.initials: N
authors.lastname: Tarikci
authors.affiliation: Department of Dermatology, Okmeydanı Training and Research Hospital, 34384 Istanbul, Turkey.
authors.forename: Emek
authors.initials: E
authors.lastname: Kocatürk
authors.affiliation: Department of Dermatology, Okmeydanı Training and Research Hospital, 34384 Istanbul, Turkey.
authors.forename: Şule
authors.initials: Ş
authors.lastname: Güngör
authors.affiliation: Department of Dermatology, Okmeydanı Training and Research Hospital, 34384 Istanbul, Turkey.
authors.forename: Ilteriş Oğuz
authors.initials: IO
authors.lastname: Topal
authors.affiliation: Department of Dermatology, Okmeydanı Training and Research Hospital, 34384 Istanbul, Turkey.
authors.forename: Pelin Ülkümen
authors.initials: PÜ
authors.lastname: Can
authors.affiliation: Department of Dermatology, Okmeydanı Training and Research Hospital, 34384 Istanbul, Turkey.
authors.forename: Ralfi
authors.initials: R
authors.lastname: Singer
mesh_terms: D004194:Disease; D015658:HIV Infections / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008099:Liver / Q000473:pathology; D011537:Pruritus / Q000209:etiology* / Q000628:therapy*; D014511:Uremia / Q000150:complications