title: Science and engineering of nanodiamond particle surfaces for biological applications (Review).
abstract: Diamond has outstanding bulk properties such as super hardness, chemical inertness, biocompatibility, luminescence, to name just a few. In the nanoworld, in order to exploit these outstanding bulk properties, the surfaces of nanodiamond (ND) particles must be accordingly engineered for specific applications. Modification of functional groups on the ND's surface and the corresponding electrostatic properties determine their colloidal stability in solvents, formation of photonic crystals, controlled adsorption and release of cargo molecules, conjugation with biomolecules and polymers, and cellular uptake. The optical activity of the luminescent color centers in NDs depends on their proximity to the ND's surface and surface termination. In order to engineer the ND surface, a fundamental understanding of the specific structural features and sp(3)-sp(2) phase transformations on the surface of ND particles is required. In the case of ND particles produced by detonation of carbon containing explosives (detonation ND), it should also be taken into account that its structure depends on the synthesis parameters and subsequent processing. Thus, for development of a strategy of surface modification of detonation ND, it is imperative to know details of its production. In this review, the authors discuss ND particles structure, strategies for surface modification, electrokinetic properties of NDs in suspensions, and conclude with a brief overview of the relevant bioapplications.
authors.affiliation: Adámas Nanotechnologies Inc., 8100 Brownleigh Dr., Raleigh, North Carolina 27617.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Shenderova
authors.affiliation: International Technology Center, 8100 Brownleigh Dr., Raleigh, North Carolina 27617.
authors.forename: Gary E
authors.initials: GE
authors.lastname: McGuire
mesh_terms: D015374:Biosensing Techniques / Q000379:methods; D055598:Chemical Phenomena; D058612:Nanodiamonds; D050997:Nanomedicine / Q000379:methods; D036103:Nanotechnology / Q000379:methods; D013499:Surface Properties
chemical_list: D058612:Nanodiamonds