title: A novel drug delivery of 5-fluorouracil device based on TiO2/ZnS nanotubes.
abstract: The structural and electronic properties of titanium oxide nanotubes (TiO2) have attracted considerable attention for the development of therapeutic devices and imaging probes for nanomedicine. However, the fluorescence response of TiO2 has typically been within ultraviolet spectrum. In this study, the surface modification of TiO2 nanotubes with ZnS quantum dots was found to produce a red shift in the ultra violet emission band. The TiO2 nanotubes used in this work were obtained by sol-gel template synthesis. The ZnS quantum dots were deposited onto TiO2 nanotube surface by a micelle-template inducing reaction. The structure and morphology of the resulting hybrid TiO2/ZnS nanotubes were investigated by scanning electron microscopy, transmission electron microscopy and X-ray diffraction techniques. According to the results of fluorescence spectroscopy, pure TiO2 nanotubes exhibited a high emission at 380nm (3.26eV), whereas TiO2/ZnS exhibited an emission at 410nm (3.02eV). The TiO2/ZnS nanotubes demonstrated good bio-imaging ability on sycamore cultured plant cells. The biocompatibility against mammalian cells (Chinese Hamster Ovarian Cells-CHO) suggesting that TiO2/ZnS may also have suitable optical properties for use as biological markers in diagnostic medicine. The drug release characteristic of TiO2/ZnS nanotubes was explored using 5-fluorouracil (5-FU), an anticancer drug used in photodynamic therapy. The results show that the TiO2/ZnS nanotubes are a promising candidate for anticancer drug delivery systems.
authors.affiliation: Institute of Physics and Chemistry, Federal University of Itajubá (UNIFEI), Av. BPS, 1303, Pinheirinho, Itajubá, MG, PO Box 50, CEP: 37500-903, Brazil; Nanomedicine and Nanotoxicology Laboratory, São Carlos Institute of Physics, University of São Paulo. Av. Trabalhador São-carlense, 400, Arnold Schimidt, São Carlos, SP CEP: 13566-590, Brazil. Electronic address: henrique.fisica@ifsc.usp.br.
authors.forename: Henrique Antonio Mendonça
authors.initials: HA
authors.lastname: Faria
authors.affiliation: Institute of Physics and Chemistry, Federal University of Itajubá (UNIFEI), Av. BPS, 1303, Pinheirinho, Itajubá, MG, PO Box 50, CEP: 37500-903, Brazil. Electronic address: alencar@unifei.edu.br.
authors.forename: Alvaro Antonio Alencar
authors.initials: AA
authors.lastname: de Queiroz
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D043942:Nanotubes / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D014025:Titanium / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D017967:Zinc Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D013440:Sulfides; D017967:Zinc Compounds; C009495:titanium dioxide; D014025:Titanium; C031238:zinc sulfide; D005472:Fluorouracil
keywords: 5-Fluorouracil; Hybrid TiO(2)/ZnS nanotubes; TiO(2) nanotube; ZnS quantum dots