title: Copeptin: Pathophysiology and potential clinical impact.
abstract: Copeptin, a C-terminal part of the precursor pre-provasopressin is a novel biomarker of arginine-vasopressin (AVP) system. Measurements of AVP concentration are not used in clinical practice because of technical difficulties. Copeptin is synthesized in stoichiometric ratio with AVP, hence it reflects vasopressin concentration in human plasma and serum. This review outlines current research concerning the role of copeptin as a prognostic marker in different diseases and its potential clinical value.
authors.affiliation: 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Łukaszyk
authors.affiliation: 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University of Bialystok, Bialystok, Poland. Electronic address: jolmal@poczta.onet.pl.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Małyszko
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D006020:Glycopeptides / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000378:metabolism
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins; D001127:Arginine Vasopressin
keywords: Chronic heart failure; Chronic kidney disease; Copeptin; Vasopressin