title: Boron containing magnetic nanoparticles for neutron capture therapy--an innovative approach for specifically targeting tumors.
abstract: The selective delivery of (10)B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. Magnetic Drug Targeting using intraarterially administered superparamagnetic nanoparticles and external magnetic fields already exhibited convincing results in terms of highly efficient and selective drug deposition. Using the same technique for the targeted (10)B delivery is a promising new approach. Here, systematic irradiation experiments of phantom cubes containing different concentrations of boron and nanoparticles as well as varying three-dimensional arrangements have been performed.
authors.affiliation: ENT - Department, Else Kröner-Fresenius-Stiftung Professorship, Section for Experimental Oncology and Nanomedicine (SEON), University Hospital Erlangen, Erlangen, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Tietze
authors.affiliation: ENT - Department, Else Kröner-Fresenius-Stiftung Professorship, Section for Experimental Oncology and Nanomedicine (SEON), University Hospital Erlangen, Erlangen, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Unterweger
authors.affiliation: ENT - Department, Else Kröner-Fresenius-Stiftung Professorship, Section for Experimental Oncology and Nanomedicine (SEON), University Hospital Erlangen, Erlangen, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Dürr
authors.affiliation: ENT - Department, Else Kröner-Fresenius-Stiftung Professorship, Section for Experimental Oncology and Nanomedicine (SEON), University Hospital Erlangen, Erlangen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Lyer
authors.affiliation: Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II), Technische Universität München, 85748 Garching, Germany.
authors.forename: Lea
authors.initials: L
authors.lastname: Canella
authors.affiliation: Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II), Technische Universität München, 85748 Garching, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Kudejova
authors.affiliation: Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II), Technische Universität München, 85748 Garching, Germany.
authors.forename: Franz M
authors.initials: FM
authors.lastname: Wagner
authors.affiliation: Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II), Technische Universität München, 85748 Garching, Germany.
authors.forename: Winfried
authors.initials: W
authors.lastname: Petry
authors.affiliation: Chair of Chemical Engineering I (Reaction Engineering), University Erlangen-Nürnberg, Germany.
authors.forename: Nicola
authors.initials: N
authors.lastname: Taccardi
authors.affiliation: ENT - Department, Else Kröner-Fresenius-Stiftung Professorship, Section for Experimental Oncology and Nanomedicine (SEON), University Hospital Erlangen, Erlangen, Germany. Electronic address: c.alexiou@web.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Alexiou
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000379:methods*; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles; D009369:Neoplasms / Q000532:radiotherapy*
keywords: BNCT; Magnetic Drug Targeting; Nanomedicine