title: Age, Body Mass Index, and Daytime and Nocturnal Hypoxia as Predictors of Hypertension in Patients With Obstructive Sleep Apnea.
abstract: A growing body of evidence links obstructive sleep apnea (OSA) with hypertension. The authors performed a retrospective cohort study using the University Hospital of Larissa Sleep Apnea Database (1501 patients) to determine predictors of in-laboratory diagnosed OSA for development of hypertension. Differences in continuous variables were assessed via independent samples t test, whereas discrete variables were compared by Pearson's chi-square test. Multivariate analysis was performed via discriminant function analysis. There were several significant differences between hypertensive and normotensive patients. Age, body mass index, comorbidity, daytime oxygen saturation, and indices of hypoxia during sleep were deemed the most accurate predictors of hypertension, whereas apnea-hypopnea index and desaturation index were not. The single derived discriminant function was statistically significant (Wilk's lambda=0.771, χ(2) =289.070, P<.0001). Daytime and nocturnal hypoxia as consequences of chronic intermittent hypoxia play a central role in OSA-related hypertension and should be further evaluated as possible severity markers in OSA.
authors.affiliation: Respiratory Medicine Department, University Hospital of Larissa, Larissa, Greece.
authors.forename: Georgios
authors.identifier: http://orcid.org/0000-0002-0088-1608
authors.initials: G
authors.lastname: Natsios
authors.affiliation: Respiratory Medicine Department, University Hospital of Larissa, Larissa, Greece.|Sleep Laboratory, University Hospital of Larissa, Larissa, Greece.
authors.forename: Chaido
authors.initials: C
authors.lastname: Pastaka
authors.affiliation: Respiratory Medicine Department, University Hospital of Larissa, Larissa, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Vavougios
authors.affiliation: Department of Physiology, University of Thessaly Medical School, Larissa, Greece.
authors.forename: Sotirios G
authors.initials: SG
authors.lastname: Zarogiannis
authors.affiliation: Respiratory Medicine Department, University Hospital of Larissa, Larissa, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Tsolaki
authors.affiliation: Respiratory Medicine Department, University Hospital of Larissa, Larissa, Greece.
authors.forename: Andreas
authors.initials: A
authors.lastname: Dimoulis
authors.affiliation: Sleep Laboratory, University Hospital of Larissa, Larissa, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Seitanidis
authors.affiliation: Respiratory Medicine Department, University Hospital of Larissa, Larissa, Greece.|Sleep Laboratory, University Hospital of Larissa, Larissa, Greece.
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Gourgoulianis
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D006115:Greece; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D000860:Hypoxia / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010092:Oximetry / Q000379:methods; D010101:Oxygen Consumption; D017286:Polysomnography / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D013223:Statistics as Topic; D013997:Time Factors