title: Heparin versus DNA: Chiral Preferences in Polyanion Binding to Self-Assembled Multivalent (SAMul) Nanostructures.
abstract: This communication presents simple cationic self-assembling multivalent (SAMul) first generation dendrons based on L or D lysine, which form identical nanoscale assemblies in terms of dimensions and charge densities but toward which DNA and heparin exhibit different chiral binding preferences. However, higher generation dendrons with larger hydrophilic head groups are bound identically by these polyanions, irrespective of chirality. We propose that well-organized chiral ligands on the surface of self-assembled nanostructures can exhibit enantioselective polyanion binding. This demonstrates that small structural changes can be amplified by self-assembly and impact on nanoscale binding.
authors.affiliation: Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Bromfield
authors.affiliation: Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.
authors.forename: David K
authors.initials: DK
authors.lastname: Smith
mesh_terms: D000838:Anions / Q000737:chemistry; D001665:Binding Sites; D001667:Binding, Competitive; D002412:Cations / Q000737:chemistry; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism; D000067493:Dynamic Light Scattering; D006493:Heparin / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D008239:Lysine / Q000737:chemistry; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D000838:Anions; D002412:Cations; D050091:Dendrimers; D008024:Ligands; D008823:Micelles; D006493:Heparin; D004247:DNA; D008239:Lysine