title: NETs and traps delay wound healing in diabetes.
abstract: Diabetes is associated with dire peripheral sequelae including foot ulcers and amputations. A recent article by Wong et al. demystifies this connection by demonstrating that the neutrophil defense mechanism of extruding decondensed chromatin, termed NETosis, mediates delayed wound healing in diabetes and provides a therapeutic strategy for this indication.
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Rachel J
authors.initials: RJ
authors.lastname: Roth Flach
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: Michael.Czech@umassmed.edu.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Czech
mesh_terms: D002956:Citrulline / Q000378:metabolism; D048909:Diabetes Complications / Q000473:pathology*; D065206:Extracellular Traps / Q000187:drug effects; D006801:Humans; D006867:Hydrolases / Q000235:genetics / Q000378:metabolism; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases; D014945:Wound Healing / Q000187:drug effects
chemical_list: D002956:Citrulline; D006867:Hydrolases; C000629235:PADI4 protein, human; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases