title: Fresh Frozen Plasma Administration in the Neonatal Intensive Care Unit: Evidence-Based Guidelines.
abstract: Neonates receiving fresh frozen plasma (FFP) should do so according to evidence-based guidelines so as to reduce inappropriate use of this life-saving and costly blood product and to minimize associated adverse effects. The consensus-based uses of FFP in neonatology involve neonates with active bleeding and associated coagulopathy. However, because of limited and poor-quality evidence, considerable FFP utilization occurs outside these recommendations. In this review, we describe what we conclude are currently the best practices for the use of FFP in neonates, including interpreting neonatal coagulation tests and strategies for reducing unnecessary FFP transfusions.
authors.affiliation: Neonatology and Neonatal Intensive Care Unit, Children's Hospital of Brescia, Spedali Civili of Brescia, P.le Spedali Civili, Brescia 25123, Italy. Electronic address: mario.motta@spedalicivili.brescia.it.
authors.forename: Mario
authors.initials: M
authors.lastname: Motta
authors.affiliation: Neonatal Intensive Care Unit, Division of Neonatology, Department of Women's and Children's Health, Di Venere Hospital, ASL Bari, Bari 70012, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Del Vecchio
authors.affiliation: Neonatology and Neonatal Intensive Care Unit, Children's Hospital of Brescia, Spedali Civili of Brescia, P.le Spedali Civili, Brescia 25123, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Chirico
mesh_terms: D016913:Blood Component Transfusion / Q000379:methods* / Q000592:standards*; D019983:Guideline Adherence; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D010949:Plasma
keywords: Coagulation tests; Fresh frozen plasma; Guidelines; Neonate; Transfusion