title: Ischemia-Modified Albumin and Atherosclerosis in Patients With Familial Mediterranean Fever.
abstract: The constriction of vessels due to atherosclerotic lesions causes hypoxia/ischemia and oxidative changes resulting in transformation of free albumin to ischemia-modified albumin (IMA) in the circulation and increased carotid intima-media thickness (cIMT). We investigated the reliability of IMA increase in evaluating atherosclerosis in patients with familial Mediterranean fever (FMF) compared with cIMT. Patients with FMF (n = 58) diagnosed by the Tel-Hashomer criteria in attack-free period and 38 healthy people were included in the study. Patient demographics as well as the clinical and laboratory characteristics of the healthy controls and patients with FMF were noted. The IMA levels and cIMT in patients with FMF were 0.30 ± 0.09 absorbance units (ABSUs) and 1.12 ± 0.27 mm, respectively, and in the control group, IMA levels and cIMT were 0.25 ± 0.07 ABSU and 0.74 ± 0.26 mm, respectively. The IMA levels and cIMT were significantly higher in patients with FMF than in controls (P= .020 andP< .0001, respectively). The IMA values showed positive correlation with cIMT in patients with FMF(r= .302,P= .041). Our results reveal that IMA--an oxidative stress marker--may be an indicator of atherosclerosis in patients with FMF. This finding deserves further investigation.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Kucuk
authors.affiliation: Department of Internal Medicine, Eskisehir Military Hospital, Eskisehir, Turkey.
authors.forename: Ali Ugur
authors.initials: AU
authors.lastname: Uslu
authors.affiliation: Department of Internal Medicine, Division of Immunology and Allergy, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Department of Cardiology, Gulhane School of Medicine, Ankara, Turkey drsevketb@gmail.com sevketb@gata.edu.tr.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: Department of Cardiology, Gulhane School of Medicine, Ankara, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: Department of Biochemistry, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Saliha
authors.initials: S
authors.lastname: Uysal
authors.affiliation: Department of Physical Medicine and Rehabilitation, Bingol State Hospital, Bingol, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yılmaz
authors.affiliation: Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Sakız
authors.affiliation: Department of Cardiology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kayrak
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000096:biosynthesis; D059168:Carotid Intima-Media Thickness; D010505:Familial Mediterranean Fever / Q000097:blood / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism*; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D002097:C-Reactive Protein; D000075462:Serum Albumin, Human
keywords: atherosclerosis; carotid intima–media thickness; familial Mediterranean fever; ischemia-modified albumin; systemic inflammation