title: Diverse Roles of Heparan Sulfate and Heparin in Wound Repair.
abstract: Heparan sulfate (HS) and heparin (Hp) are linear polysaccharide chains composed of repeating (1→4) linked pyrosulfuric acid and 2-amino-2-deoxy glucopyranose (glucosamine) residue. Mentioned glycosaminoglycans chains are covalently O-linked to serine residues within the core proteins creating heparan sulfate/heparin proteoglycans (HSPG). The latter ones participate in many physiological and pathological phenomena impacting both the plethora of ligands such as cytokines, growth factors, and adhesion molecules and the variety of the ECM constituents. Moreover, HS/Hp determine the effective wound healing process. Initial growth of HS and Hp amount is pivotal during the early phase of tissue repair; however heparan sulfate and heparin also participate in further stages of tissue regeneration.
authors.affiliation: Department of Community Pharmacy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Olczyk
authors.affiliation: Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Jednosci 8, 41-200 Sosnowiec, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Mencner
authors.affiliation: Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Jednosci 8, 41-200 Sosnowiec, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Komosinska-Vassev
mesh_terms: D000818:Animals; D006493:Heparin / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D006497:Heparan Sulfate / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D006493:Heparin; D006497:Heparan Sulfate