title: Cognitive Bias by Gender Interaction on N170 Response to Emotional Facial Expressions in Major and Minor Depression.
abstract: States of depression are considered to relate to a cognitive bias reactivity to emotional events. Moreover, gender effect may influence differences in emotional processing. The current study is to investigate whether there is an interaction of cognitive bias by gender on emotional processing in minor depression (MiD) and major depression (MaD). N170 component was obtained during a visual emotional oddball paradigm to manipulate the processing of emotional information in 33 MiD, 36 MaD, and 32 controls (CN). Compared with CN, in male, both MiD and MaD had lower N170 amplitudes for happy faces, but MaD had higher N170 amplitudes for sad faces; in female, both MiD and MaD had lower N170 amplitudes for happy and neutral faces, but higher N170 amplitudes for sad faces. Compared with MaD in male, MiD had higher N170 amplitudes for happy faces, lower N170 amplitudes for sad faces; in female, MiD only had higher N170 amplitudes for sad faces. Interestingly, a negative relationship was observed between N170 amplitude and the HDRS score for identification of happy faces in depressed patients while N170 amplitude was positively correlated with the HDRS score for sad faces identification. These results provide novel evidence for the mood-brightening effect with an interaction of cognitive bias by gender on emotional processing. It further suggests that female depression may be more vulnerable than male during emotional face processing with the unconscious negative cognitive bias and depressive syndromes may exist on a spectrum of severity on emotional face processing.
authors.affiliation: Center for Mental Disease Control and Prevention, Third Hospital of the People's Liberation Army, No. 45, Dongfeng Road, Baoji, 721004, Shaanxi, People's Republic of China.
authors.forename: Xingqu
authors.initials: X
authors.lastname: Wu
authors.affiliation: Center for Mental Disease Control and Prevention, Third Hospital of the People's Liberation Army, No. 45, Dongfeng Road, Baoji, 721004, Shaanxi, People's Republic of China. ericcst@aliyun.com.|Department of Neurology of Affiliated ZhongDa Hospital, Medical School and Institute of Neuropsychiatry of Southeast University, 87 DingJiaQiao Road, Nanjing, 210009, Jiangsu, People's Republic of China. ericcst@aliyun.com.
authors.forename: Jiu
authors.initials: J
authors.lastname: Chen
authors.affiliation: Center for Mental Disease Control and Prevention, Third Hospital of the People's Liberation Army, No. 45, Dongfeng Road, Baoji, 721004, Shaanxi, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Jia
authors.affiliation: Center for Mental Disease Control and Prevention, Third Hospital of the People's Liberation Army, No. 45, Dongfeng Road, Baoji, 721004, Shaanxi, People's Republic of China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Ma
authors.affiliation: Center for Mental Disease Control and Prevention, Third Hospital of the People's Liberation Army, No. 45, Dongfeng Road, Baoji, 721004, Shaanxi, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Mental Disease Control and Prevention, Third Hospital of the People's Liberation Army, No. 45, Dongfeng Road, Baoji, 721004, Shaanxi, People's Republic of China.
authors.forename: Zihe
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Center for Mental Disease Control and Prevention, Third Hospital of the People's Liberation Army, No. 45, Dongfeng Road, Baoji, 721004, Shaanxi, People's Republic of China. yanglaiqi6666@163.com.
authors.forename: Laiqi
authors.initials: L
authors.lastname: Yang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015982:Bias; D003071:Cognition / Q000502:physiology*; D003863:Depression / Q000503:physiopathology*; D004569:Electroencephalography; D004644:Emotions / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005145:Face; D005149:Facial Expression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time; D012727:Sex Characteristics; D055815:Young Adult
keywords: Cognitive bias; Emotional facial expression; Event-related potentials; Gender differences; Major depression; Minor depression