title: Constitutive and Inducible Expression of the rRNA Methylase Gene erm(B) in Campylobacter.
abstract: Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients and food-producing animals. Constitutive expression of erm(B) was associated with insertion and deletion in the regulatory region of the gene, providing the first documentation of the differential expression of erm(B) in Campylobacter bacteria.
authors.affiliation: National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University, Beijing, China College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
authors.forename: Fengru
authors.initials: F
authors.lastname: Deng
authors.affiliation: National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Shen
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
authors.forename: Maojun
authors.initials: M
authors.lastname: Zhang
authors.affiliation: National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Congming
authors.initials: C
authors.lastname: Wu
authors.affiliation: College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA wangyang@cau.edu.cn zhang123@iastate.edu.
authors.forename: Qijing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University, Beijing, China wangyang@cau.edu.cn zhang123@iastate.edu.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002167:Campylobacter / Q000187:drug effects / Q000201:enzymology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase