title: Numerical modeling of heart valves using resistive Eulerian surfaces.
abstract: The goal of this work is the development and numerical implementation of a mathematical model describing the functioning of heart valves. To couple the pulsatile blood flow with a highly deformable thin structure (the valve's leaflets), a resistive Eulerian surfaces framework is adopted. A lumped-parameter model helps to couple the movement of the leaflets with the blood dynamics. A reduced circulation model describes the systemic hemodynamics and provides a physiological pressure profile at the downstream boundary of the valve. The resulting model is relatively simple to describe for a healthy valve and pathological heart valve functioning while featuring an affordable computational burden. Efficient time and spatial discretizations are considered and implemented. We address in detail the main features of the proposed method, and we report several numerical experiments for both two-dimensional and three-dimensional cases with the aim of illustrating its accuracy. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Computer Vision Laboratory, Institut für Bildverarbeitung, Department of Information Technology and Electrical Engineering, Swiss Federal Institute of Technology-ETHZ, CH-8092, Zürich, Switzerland.
authors.forename: Aymen
authors.initials: A
authors.lastname: Laadhari
authors.affiliation: Modeling and Scientific Computing, Mathematics Institute of Computational Science and Engineering (MATHICSE), École Polytechnique Fédérale de Lausanne-EPFL, CH-1015, Lausanne, Switzerland.
authors.forename: Alfio
authors.initials: A
authors.lastname: Quarteroni
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D020342:Finite Element Analysis; D006351:Heart Valves / Q000033:anatomy & histology* / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular
keywords: finite element method; heart valves; hemodynamics; level set; numerical modeling; reduced order modeling