title: Metabolic syndrome in first-time hospitalized patients with depression: a 1-year follow-up study.
abstract: OBJECTIVE
  Studies on metabolic syndrome (MetS) in younger patients with depression are few. We examined the prevalence and progression of MetS in first-time hospitalized patients with depression during 1 year of follow-up. Furthermore, we explored putative risk factors of MetS.
  
  
  METHODS
  We evaluated MetS and its components in first-time hospitalized patients with depression (N = 52) and healthy controls (N = 50) (18-45 years). Physical activity, aerobic fitness, sleeping disturbances, smoking and dietary habits, and psychopharmacological treatment were recorded at baseline for all participants and after 1 year for the patients.
  
  
  RESULTS
  Patients had significantly higher waist circumference (WC) and lower high-density lipoproteins compared with healthy controls (P < 0.05). Patients had higher prevalence of MetS, but this was not significant when adjusted for age. Patients had significant increase in WC and triglycerides and a non-significant increase in the prevalence of MetS. Antipsychotic medication (OR 10.5, 95% CI 1.18-94.14) and low aerobic fitness (OR 0.79, 95% CI 0.68-0.93) were significantly correlated with MetS (P < 0.05).
  
  
  CONCLUSIONS
  Metabolic syndrome is highly prevalent in younger, severely depressed patients and the incidence increases during 1 year of follow-up. Low aerobic fitness and use of atypical antipsychotics are strongly correlated with MetS.
authors.affiliation: The Research Unit, Department of Affective Disorders Q, Aarhus University Hospital Risskov, Risskov, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Nyboe
authors.affiliation: The Research Unit, Department of Affective Disorders Q, Aarhus University Hospital Risskov, Risskov, Denmark.
authors.forename: C H
authors.initials: CH
authors.lastname: Vestergaard
authors.affiliation: SEARCH - Research Group for Synthesis of Evidence and Research, Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Sciences and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.|Centre for Evidence-based Practice, Bergen University College, Bergen, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Lund
authors.affiliation: Department of Medicine, Horsens Regional Hospital, Horsens, Denmark.
authors.forename: M K
authors.initials: MK
authors.lastname: Møller
authors.affiliation: The Research Unit, Department of Affective Disorders Q, Aarhus University Hospital Risskov, Risskov, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Videbech
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D003863:Depression / Q000378:metabolism* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000523:psychology*; D008875:Middle Aged; D010809:Physical Fitness / Q000502:physiology; D015995:Prevalence; D012307:Risk Factors; D014280:Triglycerides / Q000378:metabolism; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D014280:Triglycerides
keywords: aerobic fitness; antipsychotics; depression; metabolic syndrome