title: Role of Ethylene and Its Cross Talk with Other Signaling Molecules in Plant Responses to Heavy Metal Stress.
abstract: Excessive heavy metals (HMs) in agricultural lands cause toxicities to plants, resulting in declines in crop productivity. Recent advances in ethylene biology research have established that ethylene is not only responsible for many important physiological activities in plants but also plays a pivotal role in HM stress tolerance. The manipulation of ethylene in plants to cope with HM stress through various approaches targeting either ethylene biosynthesis or the ethylene signaling pathway has brought promising outcomes. This review covers ethylene production and signal transduction in plant responses to HM stress, cross talk between ethylene and other signaling molecules under adverse HM stress conditions, and approaches to modify ethylene action to improve HM tolerance. From our current understanding about ethylene and its regulatory activities, it is believed that the optimization of endogenous ethylene levels in plants under HM stress would pave the way for developing transgenic crops with improved HM tolerance.
authors.affiliation: School of Biotechnology, International University, Vietnam National University, Ho Chi Minh 70000, Vietnam (N.P.T., N.B.A.T., X.L.T.H.);Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India (M.I.R.K., M.A., N.A.K.); andSignaling Pathway Research Unit, RIKEN Center for Sustainable Resource Science, Tsurumi, Yokohama 2300045, Japan (L.-S.P.T.).
authors.forename: Nguyen Phuong
authors.initials: NP
authors.lastname: Thao
authors.affiliation: School of Biotechnology, International University, Vietnam National University, Ho Chi Minh 70000, Vietnam (N.P.T., N.B.A.T., X.L.T.H.);Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India (M.I.R.K., M.A., N.A.K.); andSignaling Pathway Research Unit, RIKEN Center for Sustainable Resource Science, Tsurumi, Yokohama 2300045, Japan (L.-S.P.T.).
authors.forename: M Iqbal R
authors.initials: MI
authors.lastname: Khan
authors.affiliation: School of Biotechnology, International University, Vietnam National University, Ho Chi Minh 70000, Vietnam (N.P.T., N.B.A.T., X.L.T.H.);Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India (M.I.R.K., M.A., N.A.K.); andSignaling Pathway Research Unit, RIKEN Center for Sustainable Resource Science, Tsurumi, Yokohama 2300045, Japan (L.-S.P.T.).
authors.forename: Nguyen Binh Anh
authors.initials: NB
authors.lastname: Thu
authors.affiliation: School of Biotechnology, International University, Vietnam National University, Ho Chi Minh 70000, Vietnam (N.P.T., N.B.A.T., X.L.T.H.);Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India (M.I.R.K., M.A., N.A.K.); andSignaling Pathway Research Unit, RIKEN Center for Sustainable Resource Science, Tsurumi, Yokohama 2300045, Japan (L.-S.P.T.).
authors.forename: Xuan Lan Thi
authors.initials: XL
authors.lastname: Hoang
authors.affiliation: School of Biotechnology, International University, Vietnam National University, Ho Chi Minh 70000, Vietnam (N.P.T., N.B.A.T., X.L.T.H.);Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India (M.I.R.K., M.A., N.A.K.); andSignaling Pathway Research Unit, RIKEN Center for Sustainable Resource Science, Tsurumi, Yokohama 2300045, Japan (L.-S.P.T.).
authors.forename: Mohd
authors.initials: M
authors.lastname: Asgher
authors.affiliation: School of Biotechnology, International University, Vietnam National University, Ho Chi Minh 70000, Vietnam (N.P.T., N.B.A.T., X.L.T.H.);Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India (M.I.R.K., M.A., N.A.K.); andSignaling Pathway Research Unit, RIKEN Center for Sustainable Resource Science, Tsurumi, Yokohama 2300045, Japan (L.-S.P.T.).
authors.forename: Nafees A
authors.identifier: http://orcid.org/0000-0001-7957-5832
authors.initials: NA
authors.lastname: Khan
authors.affiliation: School of Biotechnology, International University, Vietnam National University, Ho Chi Minh 70000, Vietnam (N.P.T., N.B.A.T., X.L.T.H.);Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India (M.I.R.K., M.A., N.A.K.); andSignaling Pathway Research Unit, RIKEN Center for Sustainable Resource Science, Tsurumi, Yokohama 2300045, Japan (L.-S.P.T.) son.tran@riken.jp.
authors.forename: Lam-Son Phan
authors.initials: LS
authors.lastname: Tran
mesh_terms: D005030:Ethylenes / Q000378:metabolism*; D019216:Metals, Heavy / Q000633:toxicity*; D010937:Plant Growth Regulators / Q000378:metabolism*; D010944:Plants / Q000187:drug effects / Q000378:metabolism*; D020239:Receptor Cross-Talk; D015398:Signal Transduction; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D005030:Ethylenes; D019216:Metals, Heavy; D010937:Plant Growth Regulators; C036216:ethylene