title: Late-life memory trajectories in relation to incident dementia and regional brain atrophy.
abstract: The trajectory, or slope, of cognitive decline may provide differentiation of older adults with and without incipient neurodegenerative disease. Cognitive aging phenotypes based on memory trajectories could be used as outcome measures for clinical trials or observational studies of risk and protective factors for dementia. This study used growth mixture modeling (GMM) to identify trajectory groups based on age- and education-corrected composite memory scores derived from immediate, delayed and recognition trials of the Selective Reminding Test. Participants included 2593 participants initially without dementia (mean age at entry = 76) in a community-based study of aging and dementia in northern Manhattan. Trajectory groups were compared on consensus diagnoses of dementia and structural MRI measures of hippocampal volume and entorhinal cortical thickness. Heterogeneity in memory trajectories allowed us to identify four groups: Stable-High (43.5 %), Stable-Low (17.1 %), Decliner (26.8 %), and Rapid Decliner (12.5 %). Decliners had more brain atrophy and higher rates of conversion to dementia. This study highlights the heterogeneity in cognitive aging and provides evidence that most elderly maintain memory function as they age. Associations with dementia and imaging measures validate subgroups of older adults identified with GMM based on their memory trajectories. Future research should use these memory trajectory phenotypes to determine whether dementia risk and protective factors differ for individuals following different memory trajectories.
authors.affiliation: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.|The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Laura B
authors.initials: LB
authors.lastname: Zahodne
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Biostatistics, School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Melanie M
authors.initials: MM
authors.lastname: Wall
authors.affiliation: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.|Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Schupf
authors.affiliation: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.|The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
authors.affiliation: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.|The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Manly
authors.affiliation: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.|The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Stern
authors.affiliation: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA. amb2139@columbia.edu.|The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. amb2139@columbia.edu.|Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. amb2139@columbia.edu.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology; D001284:Atrophy / Q000473:pathology; D003704:Dementia / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D009519:New York City / Q000453:epidemiology
keywords: Alzheimer’s disease; Cognitive aging; MRI