title: Resveratrol ameliorates cisplatin-induced oxidative injury in New Zealand rabbits.
abstract: This study investigated the preventive role of resveratrol in cisplatin-induced nephrotoxicity. The study used groups of New Zealand rabbits that were treated as follows: group C (cisplatin treated), group R (resveratrol treated), group R+C (resveratrol + cisplatin treatment), and group E (control group). Kidney levels of glutathione were significantly lower in group C than in groups E and R, whereas glutathione levels in group R+C were found to be similar to the control values. Malondialdehyde levels in group C were significantly higher than in groups E and R. However, malondialdehyde levels in group R+C were similar to group E. Kidney levels of nitric oxide were significantly higher in the cisplatin group than in the control, whereas nitric oxide levels were at basal values in group R+C. Cisplatin treatment significantly reduced kidney levels of glutathione peroxidase, superoxide dismutase, and catalase activity compared with those of group E, whereas resveratrol treatment significantly increased levels of glutathione peroxidase, superoxide dismutase, and catalase activity in group R+C. However, cisplatin injection did not affect mRNA levels of glutathione peroxidase, superoxide dismutase, or catalase enzymes. Histopathological and immunohistochemical analyses indicated that cisplatin caused kidney damage, which was mostly prevented by resveratrol treatment. In conclusion, resveratrol ameliorates cisplatin-induced oxidative injury in the kidney of rabbit.
authors.affiliation: a Inonu University, Medical Faculty, Department of Medical Biology and Genetics, Malatya, Turkey.
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Cigremis
authors.affiliation: b TUBITAK Ulusal Metroloji Enstitüsü (UME), Bioanalysis Laboratory, 41470 Gebze, Kocaeli, Turkey.
authors.forename: Muslum
authors.initials: M
authors.lastname: Akgoz
authors.affiliation: c Kafkas University, Department of Pathology, Faculty of Veterinary Medicine, Kars, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Ozen
authors.affiliation: c Kafkas University, Department of Pathology, Faculty of Veterinary Medicine, Kars, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Karaman
authors.affiliation: d Mehmet Akif Ersoy University, Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Burdur, Turkey.
authors.forename: Asım
authors.initials: A
authors.lastname: Kart
authors.affiliation: b TUBITAK Ulusal Metroloji Enstitüsü (UME), Bioanalysis Laboratory, 41470 Gebze, Kocaeli, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Gecer
authors.affiliation: e Erciyes University, Department of Surgery, Faculty of Veterinary Medicine, Kayseri, Turkey.
authors.forename: Gultekin
authors.initials: G
authors.lastname: Atalan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D002945:Cisplatin; D019610:Cytoprotection; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
chemical_list: D000975:Antioxidants; D012333:RNA, Messenger; D013267:Stilbenes; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D002945:Cisplatin; D000077185:Resveratrol
keywords: antioxidant enzymes; cisplatin; cisplatine; enzymes antioxydantes; lapin; nephrotoxicity; néphrotoxicité; rabbit; resveratrol; resvératrol