title: Diphenyl ditelluride intoxication triggers histological changes in liver, kidney, and lung of mice.
abstract: Tellurium compounds may be cytotoxic to different cells types. Thus, this work evaluated the effect of diphenyl ditelluride ((PhTe)2), an organotellurium commonly used in organic synthesis, on the morphology of liver, kidney, and lung. Adult mice were acutely (a subcutaneous single dose: 250 μmol/kg) or subchronically (one daily subcutaneous dose: 10 or 50 μmol/kg for 7 and 14 days) exposed to (PhTe)2. Afterwards, the histological analyses of liver, kidney, and lungs were performed. Liver histology revealed that the hepatocytes of mice subchronically exposed to (PhTe)2 presented cytoplasmic vacuolization, hydropic degeneration, and hyperchromatic nuclei. Subchronic exposure to 50 μmol/kg (PhTe)2 also caused hepatic necrosis. Microvesicular and macrovesicular steatosis were identified in liver of mice acutely exposed to (PhTe)2. Acute and subchronic intoxication with (PhTe)2 induced changes on epithelial cells of renal tubules, namely, loss of brush border and cytoplasmatic vacuolization. Atrophy and hypertrophy, cast proteinaceous formation, and acute tubular necrosis were also identified in renal tissue. Mice subchronically exposed to 50 μmol/kg (PhTe)2 developed intra-alveolar edema and alveolar wall congestion in some areas of lungs. Acute exposure to (PhTe)2 did not cause histological changes in lungs. Our data show that (PhTe)2 may be considered a histotoxic agent for liver, kidney, and lung.
authors.affiliation: Departamento de Patologia, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Sônia Cristina Almeida
authors.initials: SC
authors.lastname: da Luz
authors.affiliation: Serviço de Patologia, Hospital Universitário de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Melissa Falster
authors.initials: MF
authors.lastname: Daubermann
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Gustavo Roberto
authors.initials: GR
authors.lastname: Thomé
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Matheus Mülling
authors.initials: MM
authors.lastname: Dos Santos
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Angelica
authors.initials: A
authors.lastname: Ramos
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Gerson
authors.initials: G
authors.lastname: Torres Salazar
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: João Batista Teixeira
authors.initials: JB
authors.lastname: da Rocha
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Nilda Vargas
authors.initials: NV
authors.lastname: Barbosa
mesh_terms: D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D009928:Organ Specificity / Q000187:drug effects; D009942:Organometallic Compounds / Q000633:toxicity*
chemical_list: D001555:Benzene Derivatives; D009942:Organometallic Compounds; C434247:diphenylditelluride