title: Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil.
abstract: Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Gabriela L da
authors.initials: GL
authors.lastname: Silva
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Carolina
authors.initials: C
authors.lastname: Luft
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Adroaldo
authors.initials: A
authors.lastname: Lunardelli
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Robson H
authors.initials: RH
authors.lastname: Amaral
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Denizar A da Silva
authors.initials: DA
authors.lastname: Melo
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Márcio V F
authors.initials: MV
authors.lastname: Donadio
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Fernanda B
authors.initials: FB
authors.lastname: Nunes
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Marcos S
authors.initials: MS
authors.lastname: de Azambuja
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: João C
authors.initials: JC
authors.lastname: Santana
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Cristina M B
authors.initials: CM
authors.lastname: Moraes
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Ricardo O
authors.initials: RO
authors.lastname: Mello
authors.affiliation: Departamento de Engenharia Química, Faculdade de Engenharia, Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cassel
authors.affiliation: Departamento de Engenharia Química, Faculdade de Engenharia, Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Marcos Aurélio de Almeida
authors.initials: MA
authors.lastname: Pereira
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BR.
authors.forename: Jarbas R
authors.initials: JR
authors.lastname: de Oliveira
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use*; D002351:Carrageenan; D003436:Croton Oil; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D027523:Lavandula; D009822:Oils, Volatile / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement; D010938:Plant Oils / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D009822:Oils, Volatile; D010938:Plant Oils; D003436:Croton Oil; D002351:Carrageenan; C045718:lavender oil