title: Macrophages decide between regeneration and fibrosis in muscle.
abstract: Defective muscle regeneration is usually accompanied by excessive matrix accumulation (fibrosis). A recent study reveals how this fibrotic process is prevented to allow successful regeneration, through a timely interplay between macrophages and fibro/adipogenic progenitor cells. This has biomedical relevance for fibrotic muscular dystrophies.
authors.affiliation: Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED), Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Electronic address: pura.munoz@upf.edu.
authors.forename: Pura
authors.initials: P
authors.lastname: Muñoz-Cánoves
authors.affiliation: Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED), Barcelona, Spain. Electronic address: antonio.serrano@upf.edu.
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Serrano
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000473:pathology*; D006801:Humans; D008264:Macrophages; D009132:Muscles / Q000473:pathology*; D012038:Regeneration
keywords: fibro/adipogenic progenitors; fibrosis; macrophages; nilotinib; regeneration