title: [The expression and significance of CD151 in pituitary adenomas].
abstract: OBJECTIVE
  To investigate the expression and significance of CD151 in pituitary adenomas.
  
  
  METHODS
  Thirty-six pituitary adenomas were collected immediately after surgery together with five normal pituitary tissue. Real time-PCR, Western blot and immunohistochemistry analysis were performed to detect the expression of CD151 mRNA and protein in thirty-six pituitary adenomases and five normal pituitary tissues.
  
  
  RESULTS
  The expression of CD151 in all pituitary adenomases was observed to be significantly higher than that in normal pituitary tissues by Western blot, real time PCR, and immunohistochemistry analysis (P < 0.01). The expression levels of protein and mRNA in invasive pituitary adenomas were much higher than those in non-invasive pituitary adenomas (P < 0.01).
  
  
  CONCLUSIONS
  The results suggested that the expression of CD151 was closely correlated with malignant degree of pituitary adenomas, which indicated the expression of CD151 was intimately correlated with occurrence and development of pituitary adenomas. Detecting CD151 might be a vital index to predict prognosis of pituitary adenomas.
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Hong
authors.forename: Zai-chang
authors.initials: ZC
authors.lastname: Hu
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.forename: Pan-pan
authors.initials: PP
authors.lastname: Sun
authors.forename: Liu-wang
authors.initials: LW
authors.lastname: Nie
authors.forename: Yan-fang
authors.initials: YF
authors.lastname: Zhou
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D015153:Blotting, Western; D006801:Humans; D007150:Immunohistochemistry; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011379:Prognosis; D012333:RNA, Messenger; D060888:Real-Time Polymerase Chain Reaction; D060185:Tetraspanin 24 / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D060185:Tetraspanin 24