title: Delayed Development of Primary Biliary Cirrhosis in a Patient with Acute Glomerulonephritis: A Possible Pitfall of a Self-limiting Disease.
abstract: Acute poststreptococcal glomerulonephritis (APSGN) is a well-established disease. Although various immune responses are thought to be involved in the pathogenesis of APSGN, the disease has a self-limiting nature in clinical practice, despite the presence of severe acute symptoms. We herein report the case of a 78-year-old woman with APSGN who developed primary biliary cirrhosis (PBC) after achieving remission of renal manifestations, including anasarca and elevation of serum creatinine, indicating that persistent alterations in the immune system can cause extrarenal disorders. This case provides insights into the appropriate clinical management of ASPGN and pathogenesis of PBC.
authors.affiliation: Division of Nephrology, Department of Medicine, Jichi Medical University, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miki
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Norio
authors.initials: N
authors.lastname: Isoda
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Mari
authors.initials: M
authors.lastname: Okada
authors.forename: Saki
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Toshimi
authors.initials: T
authors.lastname: Imai
authors.forename: Ryuta
authors.initials: R
authors.lastname: Sato
authors.forename: Osamu
authors.initials: O
authors.lastname: Saito
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nagata
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002756:Cholagogues and Choleretics / Q000008:administration & dosage*; D004232:Diuretics / Q000008:administration & dosage*; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D002756:Cholagogues and Choleretics; D004232:Diuretics; D014580:Ursodeoxycholic Acid; D000658:Amoxicillin