title: Contribution of Therapeutic Monitoring in the Assessment of Toxic Adverse Effects of Mitotane: a Case Report.
abstract: Mitotane provided serious side effects and low doses seemed to be tolerated. Determination of mitotane concentration in plasma is recommended. We report the case of toxic plasma levels with low doses of mitotane in a 47-year-old man with adrenocortical cancer.
authors.forename: Nadia
authors.initials: N
authors.lastname: Jebabli
authors.forename: Emna
authors.initials: E
authors.lastname: Gaïes
authors.forename: Hanen
authors.initials: H
authors.lastname: Eljebari
authors.forename: Rim
authors.initials: R
authors.lastname: Charfi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Lakhal
authors.forename: Anis
authors.initials: A
authors.lastname: Klouz
authors.forename: Issam
authors.initials: I
authors.lastname: Salouage
authors.forename: Sameh
authors.initials: S
authors.lastname: Trabelsi
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000188:drug therapy*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D001247:Asthenia / Q000139:chemically induced*; D002277:Carcinoma / Q000097:blood / Q000188:drug therapy*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D006801:Humans; D008297:Male; D008875:Middle Aged; D008939:Mitotane / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D009325:Nausea / Q000139:chemically induced*; D014839:Vomiting / Q000139:chemically induced*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane