title: [Effect of Compound Qingre Granule on the Expression of Peripheral Blood Lymphocyte Subsets of Acute Virus Infection Patients].
abstract: OBJECTIVE
  To observe interventional effects of anti-viral therapy and Compound Qin-gre Granule (CQG) on host cellular immune functions of acute virus infection patients.
  
  
  METHODS
  Thirty acute virus infection patients were recruited to detect peripheral lymphocyte subsets. They were randomly assigned to two groups, the Western medicine treatment group (treated with anti-virus Western medicine) and the integrative medicine treatment group (treated with anti-virus Western medicine plus CQG). T-cell subsets were re-examined 7 days later. Changes between before and after treatment were observed. Effect on host cellular immune functions and efficacy were compared between the Western medicine treatment and the integrative medicine treatment.
  
  
  RESULTS
  Compared with the normal control group, the percentage of peripheral T cells increased, and the percentage of B/NK cells decreased in acute virus infection patients (P < 0.01). Meanwhile, in T cell subsets, the percentage of CD8+ T cells and CD8+ CD38+ T cells increased (P < 0.05, P < 0.01); and percentages of CD4+ T cells, CD4+ CD28 + T cells, and CD8+ CD28+ T cells decreased (P < 0.05, P < 0.01). After one-week treatment, percentages of CD4+ T cells, CD4+ CD28+ T cells, and CD8+ CD28+ T cells increased (P < 0.05, P < 0.01), while the percentage of CD8+ CD38+ T cells decreased (P < 0.01). More significantly, these changes were greater in the integrative medicine treatment group than in the Western medicine treatment group (P < 0.05).
  
  
  CONCLUSIONS
  Disarranged cellular immune functions existed in acute virus infection patients. CQG could significantly improve viral infection induced immunologic derangement and immunologic injury.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Dong-wei
authors.initials: DW
authors.lastname: Ren
authors.forename: Shu-wen
authors.initials: SW
authors.lastname: Zhang
authors.forename: Ai-min
authors.initials: AM
authors.lastname: Ren
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
mesh_terms: D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets; D016176:T-Lymphocyte Subsets; D014777:Virus Diseases / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal