title: The search for nucleoside/nucleotide analog inhibitors of dengue virus.
abstract: Nucleoside analogs represent the largest class of antiviral agents and have been actively pursued for potential therapy of dengue virus (DENV) infection. Early success in the treatment of human immunodeficiency virus (HIV) infection and the recent approval of sofosbuvir for chronic hepatitis C have provided proof of concept for this class of compounds in clinics. Here we review (i) nucleoside analogs with known anti-DENV activity; (ii) challenges of the nucleoside antiviral approach for dengue; and (iii) potential strategies to overcome these challenges. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.
authors.affiliation: Novartis Institute for Tropical Diseases, Singapore. Electronic address: yen_liang.chen@novartis.com.
authors.forename: Yen-Liang
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Novartis Institute for Tropical Diseases, Singapore.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Yokokawa
authors.affiliation: Novartis Institute for Tropical Diseases, Singapore. Electronic address: pei_yong.shi@novartis.com.
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Shi
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D003715:Dengue / Q000188:drug therapy* / Q000821:virology; D003716:Dengue Virus / Q000187:drug effects* / Q000378:metabolism; D055808:Drug Discovery; D006801:Humans; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D009711:Nucleotides / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D009711:Nucleotides
keywords: Antiviral therapy; Dengue virus; Monophosphate prodrug; Nucleoside analogs