title: Antimicrobial efficacy of green synthesized drug blended silver nanoparticles against dental caries and periodontal disease causing microorganisms.
abstract: Development of biologically inspired green synthesis of silver nanoparticles is evolving into an important branch of nano-biotechnology. In the present investigation, we report the green synthesis of silver nanoparticles (AgNPs) employing the leaf extract of Justicia glauca. Water-soluble organics present in the leaf extract are mainly responsible for the reduction of silver nitrate (AgNO3) solution to AgNPs. The AgNPs are 10-20nm in dimensions as determined by TEM images. The antimicrobial activities of green synthesized AgNPs and drug blended AgNPs have been evaluated against the dental caries and periodontal disease causing microorganisms such as Streptococcus mutans, Staphylococcus aureus, Lactobacillus acidophilus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The AgNPs and drug blended AgNPs show a significant antibacterial and antifungal activity. Minimum inhibitory concentration (MIC) value of AgNPs determined against the selected dental caries and periodontal disease causing microorganisms are noticeable between the range of 25-75μg/mL.
authors.affiliation: Post Graduate & Research Department of Chemistry, Thiagarajar College, Madurai 625009, Tamilnadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Emmanuel
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
authors.forename: Selvakumar
authors.initials: S
authors.lastname: Palanisamy
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC. Electronic address: smchen78@ms15.hinet.net.
authors.forename: Shen-Ming
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
authors.forename: K
authors.initials: K
authors.lastname: Chelladurai
authors.affiliation: Department of Zoology and Microbiology, Thiagarajar College, Madurai 625009, Tamilnadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Padmavathy
authors.affiliation: Institute of Biomedical Sciences, College of Health Science, Mekelle University, Mekelle 1871, Ethiopia.
authors.forename: M
authors.initials: M
authors.lastname: Saravanan
authors.affiliation: Post Graduate & Research Department of Chemistry, Thiagarajar College, Madurai 625009, Tamilnadu, India. Electronic address: kmpprakash@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Prakash
authors.affiliation: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: Ajmal Ali
authors.affiliation: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Fahad M A
authors.initials: FM
authors.lastname: Al-Hemaid
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development; D002176:Candida albicans / Q000254:growth & development; D003731:Dental Caries / Q000188:drug therapy / Q000382:microbiology; D027902:Justicia / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D012834:Silver
keywords: Antimicrobial activities; Dental caries; Justicia glauca; Periodontal disease; Silver nanoparticles