title: Epidemiological and clinical features of migraine in the pediatric population of Northern Italy.
abstract: OBJECTIVE
  The aim of this article is to analyze the epidemiological and clinical features of migraine in a pediatric headache center.
  
  
  METHODS
  A retrospective study was performed over six years. Hospital record databases were screened for the diagnosis of migraine with aura (MA) or without aura (MO), based on the ICHD-II criteria.
  
  
  METHODS
  Fisher's test or Mann-Whitney U test, significance at p < 0.05.
  
  
  RESULTS
  Migraine was diagnosed in 495 children (29.7% MA, 70.3% MO). The majority of diagnoses were made between ages 9 and 14 years. After stratification for age into five groups, we observed an increase of diagnoses in females, with a peak after the age of 15 years, and an increase of MA. In both groups, the attacks were usually severe, infrequent (<1-3/month) lasting <2 hours, and associated with nausea/vomiting, photophobia, phonophobia (more frequent in MO). Osmophobia was reported in 24.7% of the patients with MO. Dizziness was more frequent in patients with MA. Visual auras were the most common occurrence (87.1%). Confusional state was observed in 10.88% of the patients. A positive family history of headache was observed in >88% of the patients.
  
  
  CONCLUSIONS
  We describe the characteristics of pediatric migraine based on the ICHD-II criteria, showing a likely significant loss of diagnoses using the ICHD-III beta. The incidence of migraine increases with age. MO occurs more commonly and shows more frequent attacks and a higher prevalence of associated symptoms, in particular osmophobia. Although males are prevalent in the entire sample, the proportion of females is higher among patients with MA in all of the age groups. Phenotype and sexual prevalence of migraine acquire adult characteristics and become more frequent in females from the onset of puberty.
authors.affiliation: ASL AT, Ospedale Cardinal Massaia, Division of Pediatrics, Italy vtarasco@asl.at.it.
authors.forename: V
authors.initials: V
authors.lastname: Tarasco
authors.affiliation: A.O.U. Città della Salute e della Scienza di Torino - Regina Margherita Children's Hospital, Department of Pediatric Emergency - Pediatric Headache Centre, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Grasso
authors.affiliation: A.O.U. Città della Salute e della Scienza di Torino - Regina Margherita Children's Hospital, Department of Pediatric Emergency - Pediatric Headache Centre, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Versace
authors.affiliation: A.O.U. Città della Salute e della Scienza di Torino - Regina Margherita Children's Hospital, Department of Pediatric Emergency - Pediatric Headache Centre, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Castagno
authors.affiliation: Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Italy Unit of Epidemiology, Regional Health Service, ASL TO3, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ricceri
authors.affiliation: A.O.U. Città della Salute e della Scienza di Torino - Regina Margherita Children's Hospital, Department of Pediatric Emergency - Pediatric Headache Centre, Italy.
authors.forename: A F
authors.initials: AF
authors.lastname: Urbino
authors.affiliation: A.O.U. Città della Salute e della Scienza di Torino - Regina Margherita Children's Hospital, Department of Pediatric Emergency - Pediatric Headache Centre, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pagliero
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008881:Migraine Disorders / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D017678:Sex Distribution
keywords: Children; International Headache Society (IHS) criteria; clinical characteristics; migraine