title: Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.
abstract: Allergic reactions to drugs are a serious public health concern. In 2013, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology, and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several National Institutes of Health institutes and the US Food and Drug Administration. The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein.
authors.affiliation: Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md. Electronic address: lisa.wheatley@nih.gov.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Wheatley
authors.affiliation: Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.
authors.forename: Marshall
authors.initials: M
authors.lastname: Plaut
authors.affiliation: Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Schwaninger
authors.affiliation: Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass.
authors.forename: Aleena
authors.initials: A
authors.lastname: Banerji
authors.affiliation: Drug Hypersensitivity and Desensitization Center, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
authors.forename: Mariana
authors.initials: M
authors.lastname: Castells
authors.affiliation: Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, University of Cincinnati College of Medicine, the Department of Medicine, Cincinnati Veterans Affairs Medical Center, and the Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Fred D
authors.initials: FD
authors.lastname: Finkelman
authors.affiliation: Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, Utah.
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Gleich
authors.affiliation: Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai Medical Center, New York, NY.
authors.forename: Emma
authors.initials: E
authors.lastname: Guttman-Yassky
authors.affiliation: Center for Translational Immunology and Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia.
authors.forename: Simon A K
authors.initials: SA
authors.lastname: Mallal
authors.affiliation: Medical Research Council Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Naisbitt
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, Division of Experimental Pathology, University of Florida College of Medicine, Gainesville, Fla.
authors.forename: David A
authors.initials: DA
authors.lastname: Ostrov
authors.affiliation: Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Phillips
authors.affiliation: ADR-AC GMBH, Holligenstr. 91, CH 3008, Bern, Switzerland.
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Pichler
authors.affiliation: Asthma and Allergic Diseases Center, Department of Medicine, University of Virginia, Charlottesville, Va.
authors.forename: Thomas A E
authors.initials: TA
authors.lastname: Platts-Mills
authors.affiliation: Université Paris-Est Créteil, 94010, Créteil, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Roujeau
authors.affiliation: Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Va.
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Schwartz
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wis.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Trepanier
mesh_terms: D002220:Carbamazepine / Q000009:adverse effects; D015224:Dideoxynucleosides / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D015870:Gene Expression; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006241:Haptens / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D054579:National Institute of Allergy and Infectious Diseases (U.S.); D017410:Practice Guidelines as Topic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D009626:Terminology as Topic; D057170:Translational Research, Biomedical / Q000639:trends*; D014481:United States / Q000453:epidemiology; D014777:Virus Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D000099227:Abacavir
chemical_list: D002220:Carbamazepine; D015224:Dideoxynucleosides; D006680:HLA Antigens; D006241:Haptens; D007073:Immunoglobulin E; D011948:Receptors, Antigen, T-Cell; D000099227:Abacavir
keywords: Drug allergy; Stevens-Johnson syndrome; altered peptide repertoire hypothesis; desensitization; drug hypersensitivity; hapten hypothesis; pharmacogenomics; pharmacologic interaction with immune receptor hypothesis; toxic epidermal necrolysis