title: Effect of Percutaneous Coronary Intervention on Left Ventricular Diastolic Function in Patients With Coronary Artery Disease.
abstract: BACKGROUND
  There is considerable disagreement over the effects of percutaneous coronary intervention (PCI) on left ventricular diastolic function that has necessitated the investigation of diastolic indices. The present study was conducted to evaluate left ventricular diastolic function and its indices, three months after performing the PCI procedure in patients with coronary artery disease (CAD).
  
  
  METHODS
  In a quasi-experimental clinical trial study (before and after), 51 patients with CAD scheduled for elective PCI were investigated provided that their Ejection Fraction (EF) was > 30%. Before and three months after PCI, echocardiography was carried out to evaluate left ventricular diastolic indices including the E/Ea as the most important criteria for diagnosis of diastolic heart failure (DHF).
  
  
  RESULTS
  Based on the E/Ea indices and after PCI, the number of patients with DHF decreased significantly: 40 patients (78.4%) before PCI versus 28 patients (54.9%) after PCI (p<0.05). The Mean and Standard error of deceleration time (DT), isovolumic relaxation time (IVRT), early diastolic mitral annulus velocity; Ea (E'), E/Ea and left ventricular ejection function (LVEF) indices underwent significant changes. In addition, MVA dur/PVA dur, PVs/PVd, and E/Ea indices had changed significantly after PCI in both genders. However, no significant difference was reported for the other indices.
  
  
  CONCLUSIONS
  The E/Ea ratio as an important criterion for diagnosis of DHF was improved after PCI. Improvement of several other diastolic indices was observed after the PCI procedure. It can be concluded that PCI can be an effective treatment modality in patients with left ventricular diastolic indices.
authors.forename: Nahid
authors.initials: N
authors.lastname: Salehi
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Saidi
authors.forename: Alireza
authors.initials: A
authors.lastname: Rai
authors.forename: Farid
authors.initials: F
authors.lastname: Najafi
authors.forename: Seedmokhtar
authors.initials: S
authors.lastname: Javeedannejad
authors.forename: Mehran
authors.initials: M
authors.lastname: Babanejad
authors.affiliation: Medical Students Research Committee (MSRC), Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. h_tadbiri@student.tums.ac.ir.
authors.forename: Hooman
authors.initials: H
authors.lastname: Tadbiri
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*