title: Targeting Interferon Regulatory Factor for Cardiometabolic Diseases: Opportunities and Challenges.
abstract: BACKGROUND
  The pathological activation of innate immune system may contribute to the development of cardiometabolic diseases. The interferon regulatory factor (IRF) family members, which are the major transcription factors in innate immune signaling, are implicated in cardiometabolic diseases.
  
  
  OBJECTIVE
  The aim of this review is to summary the current knowledge of the biological functions of IRFs in innate immune responses and immune cell development, and highlight our contemporary understanding of the functions and molecular mechanisms of IRFs in metabolic diseases, cardiovascular remodeling, and stroke.
  
  
  RESULTS
  IRFs are the essential regulators of cardiometabolic diseases via immune-dependent and - independent manners.
  
  
  CONCLUSIONS
  IRFs signaling is the promising target to manage the initiation and progression of cardiometabolic disorders.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.|Center for Animal Experiment/ ABSL-III Laboratory of Wuhan University, Wuhan 430060, China.
authors.forename: Yaxing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.|Center for Animal Experiment/ ABSL-III Laboratory of Wuhan University, Wuhan 430060, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.|Center for Animal Experiment/ ABSL-III Laboratory of Wuhan University, Wuhan 430060, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D050835:Interferon Regulatory Factors / Q000737:chemistry / Q000378:metabolism*; D008659:Metabolic Diseases / Q000188:drug therapy / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D015398:Signal Transduction
chemical_list: D050835:Interferon Regulatory Factors
keywords: Interferon regulatory factor signaling; cardiac remodeling; metabolic diseases; stroke; vascular injury; vascular remodeling