title: Perinatal psychosis in mothers with a history of major depressive disorder.
abstract: While women with a history of major depressive disorder (MDD) have higher chances for postpartum depressive and manic episodes, little is known about their chance for postpartum psychosis (PPP). We prospectively assessed the frequency of perinatal psychotic symptoms among primiparous women with a history of MDD only (structured clinical interview was used to exclude women with pre-existing histories of mania or psychosis) and explored whether sex of the baby influenced these symptoms.The presence of symptoms of psychosis was defined using previously established cutoff scores on five key items from the Positive and Negative Syndrome Scale (PANSS), which was administered during pregnancy, at 1 week, 1 month, and 3 months postpartum.Fourteen of 60 women (23%) scored above threshold for psychosis at one or more time points, with 6 experiencing postpartum onset. There was a non-significant trend (p = 0.073) towards higher frequency of these symptoms among mothers of girls.If controlled studies using diagnostic interviews confirm that psychotic symptoms are relatively common among women with MDD, monitoring for psychosis during the perinatal period may be indicated in this population. The potential effect of sex of the baby on mothers' chance for PPP requires further study.
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: Chloe E
authors.initials: CE
authors.lastname: Mighton
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.|Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Inglis
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: Prescilla B
authors.initials: PB
authors.lastname: Carrion
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.|Women's Health Research Institute, BC Women's Hospital & Health Centre, Vancouver, Canada.
authors.forename: Catriona L
authors.initials: CL
authors.lastname: Hippman
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.|Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
authors.forename: Emily M
authors.initials: EM
authors.lastname: Morris
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Andrighetti
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: Rolan
authors.initials: R
authors.lastname: Batallones
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: William G
authors.initials: WG
authors.lastname: Honer
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada. jehannine.austin@ubc.ca.|Department of Medical Genetics, University of British Columbia, Vancouver, Canada. jehannine.austin@ubc.ca.|, Rm. A3-112, CFRI Translational Lab Building, 938 W 28th Ave., Vancouver, BC, V5Z 4H4, Canada. jehannine.austin@ubc.ca.
authors.forename: Jehannine C
authors.initials: JC
authors.lastname: Austin
mesh_terms: D000293:Adolescent; D000328:Adult; D019052:Depression, Postpartum / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D003865:Major Depressive Disorder / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006801:Humans; D015994:Incidence; D007407:Interviews as Topic; D009035:Mothers / Q000523:psychology* / Q000706:statistics & numerical data; D010298:Parity; D018743:Perinatal Care; D011247:Pregnancy; D037841:Pregnant People / Q000523:psychology*; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000209:etiology / Q000523:psychology; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors
keywords: Depression; Mental illness; Postpartum; Pregnancy; Psychosis