title: A new cytotoxic biflavonoid from the rhizome of Wikstroemia indica.
abstract: One new chalcone-flavone biflavonoid, 3'-hydroxydaphnodorin A (1), together with 12 known biflavonoids (2-13), was isolated from the rhizome of Wikstroemia indica. Their structures were established on the basis of extensive spectroscopic methods. Eight isolated compounds 1-3, 6, 7, 9, 12 and 13 were evaluated for their cytotoxic activities against cancer-derived cell lines Hep3B, HepG2 and CNE2, and 1 was found to possess moderate cytotoxicity against HepG2 and CNE2 cell lines, with IC50 values of 65.5 ± 11.4 and 53.6 ± 10.1 μM, respectively.
authors.affiliation: a School of Traditional Chinese Medicine , Southern Medical University , Guangzhou 510515 , China.
authors.forename: Meng
authors.initials: M
authors.lastname: Shao
authors.affiliation: b Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.affiliation: a School of Traditional Chinese Medicine , Southern Medical University , Guangzhou 510515 , China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Liu
authors.affiliation: c Hygiene Detection Center, School of Public Health and Tropical Medicine , Southern Medical University , Guangzhou 510515 , China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Han
authors.affiliation: a School of Traditional Chinese Medicine , Southern Medical University , Guangzhou 510515 , China.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Cai
authors.affiliation: a School of Traditional Chinese Medicine , Southern Medical University , Guangzhou 510515 , China.
authors.forename: Qing-Fa
authors.initials: QF
authors.lastname: Tang
authors.affiliation: a School of Traditional Chinese Medicine , Southern Medical University , Guangzhou 510515 , China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Fan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D044946:Biflavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D032365:Wikstroemia / Q000737:chemistry*
chemical_list: C000619097:3'-hydroxydaphnodorin A; D000972:Antineoplastic Agents, Phytogenic; D044946:Biflavonoids; D010936:Plant Extracts
keywords: 3′-hydroxydaphnodorin A; Wikstroemia indica; biflavonoid; cytotoxicity