title: Noncoding RNAs and chronic inflammation: Micro-managing the fire within.
abstract: Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age-associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets.
authors.affiliation: Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Alexander
authors.affiliation: Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT, USA.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: O'Connell
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D006801:Humans; D007107:Immune System / Q000378:metabolism; D007249:Inflammation / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D022661:RNA, Untranslated
keywords: aging; autoimmunity; chronic inflammation; miRNAs; noncoding RNA