title: Antitumor efficacy of extracellular complexes with gadolinium in Binary Radiotherapy.
abstract: In this report the efficacy of extracellular pharmaceutical Gd-DTPA in Binary Radiotherapy was studied. The study was carried out in mice bearing transplantable adenocarcinoma Ca755 using X-ray based contrast enhanced radiotherapy as a practical implementation of Binary Radiotherapy. It was shown that intravenous administration of 0.3 ml of 0.5 M water solution of Gd-DTPA followed by X-irradiation at a dose of 10 Gy provides T/C%=10±3% and leads to complete tumor regression in 25% of mice.
authors.affiliation: Blokhin Russian Cancer Scientific Centre, Kashirskoe sh. 24, Moscow, Russian Federation; Burnasyan Federal Medical Biophysical Centre, Zhivopisnaya 46, Moscow, Russian Federation; National Research Nuclear University "MEPhI", Kashirskoe sh. 31, Moscow, Russian Federation. Electronic address: lipengolts@mail.ru.
authors.forename: A A
authors.initials: AA
authors.lastname: Lipengolts
authors.affiliation: Blokhin Russian Cancer Scientific Centre, Kashirskoe sh. 24, Moscow, Russian Federation; Burnasyan Federal Medical Biophysical Centre, Zhivopisnaya 46, Moscow, Russian Federation; National Research Nuclear University "MEPhI", Kashirskoe sh. 31, Moscow, Russian Federation.
authors.forename: A A
authors.initials: AA
authors.lastname: Cherepanov
authors.affiliation: Burnasyan Federal Medical Biophysical Centre, Zhivopisnaya 46, Moscow, Russian Federation.
authors.forename: V N
authors.initials: VN
authors.lastname: Kulakov
authors.affiliation: Blokhin Russian Cancer Scientific Centre, Kashirskoe sh. 24, Moscow, Russian Federation.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Grigorieva
authors.affiliation: Burnasyan Federal Medical Biophysical Centre, Zhivopisnaya 46, Moscow, Russian Federation.
authors.forename: I N
authors.initials: IN
authors.lastname: Sheino
authors.affiliation: National Research Nuclear University "MEPhI", Kashirskoe sh. 31, Moscow, Russian Federation.
authors.forename: V A
authors.initials: VA
authors.lastname: Klimanov
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy*; D000818:Animals; D005260:Female; D019786:Gadolinium DTPA / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D023041:Xenograft Model Antitumor Assays
chemical_list: D019786:Gadolinium DTPA
keywords: Adenocarcinoma; Animal study; Binary Radiotherapy; Ca755; Gadolinium; Mice; Transplanted tumors; X-rays