title: Biological Treatments in Atopic Dermatitis.
abstract: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases that affect both children and adults with a prevalence of 30% and 10%, respectively. Even though most of patients respond satisfactory to topical anti-inflammatory drugs, about 10% require one or more systemic treatments to achieve good control of their illness. The progressive and increasingly detailed knowledge in the immunopathogenesis of AD has allowed research on new therapeutic targets with very promising results in the field of biological therapy. In this article, we will review the different biological treatments with a focus on novel drugs. Their mechanism of action, current status and results from clinical trials and observational studies will be specified.
authors.affiliation: Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. andreamtg@hotmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Montes-Torres
authors.affiliation: Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. mar.llamasvelasco@gmail.com.
authors.forename: Mar
authors.initials: M
authors.lastname: Llamas-Velasco
authors.affiliation: Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. aperezplaza@gmail.com.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Pérez-Plaza
authors.affiliation: Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. guitje1@hotmail.com.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Solano-López
authors.affiliation: Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid 28006, Spain. jsanchezperez@aedv.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-Pérez
keywords: antibody therapy; atopic dermatitis; atopic eczema; biologics; pathogenesis