title: A collaborative approach to enabling stratified cancer medicine in the UK.
abstract: Embedding stratified cancer medicine into the patient pathway will require adaptation of the diagnostic pathway to incorporate predictive molecular analysis, presenting challenges of accessing tumour samples of sufficient quality and quantity for analysis and ensuring the timeliness, accuracy, and clinical validity of results. In 2010, Cancer Research UK (CRUK), in partnership with AstraZeneca and Pfizer, set up the Stratified Medicine Programme (SMP1) to work collaboratively with a small number of hospital and genetics laboratories to demonstrate the feasibility of testing large volumes of samples, while working towards more standardised and efficient processes. By June 2013, 9010 patient samples had been sent for genetic testing and here we present an overview of our experience and the wealth of insights that have been generated into the complexities of attempting this transformation of National Health Service (NHS) care.
authors.affiliation: Cancer Research UK, Angel Building, 407 St John Street, London EC1 V 4AD, UK.
authors.forename: Alice
authors.initials: A
authors.lastname: Tuff-Lacey
authors.affiliation: Cancer Research UK, Angel Building, 407 St John Street, London EC1 V 4AD, UK. Electronic address: Emily.Shaw@cancer.org.uk.
authors.forename: Emily
authors.initials: E
authors.lastname: Shaw
authors.affiliation: Cancer Research UK, Angel Building, 407 St John Street, London EC1 V 4AD, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Cummings
authors.affiliation: Cancer Research UK, Angel Building, 407 St John Street, London EC1 V 4AD, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Walker
authors.affiliation: Cancer Research UK, Angel Building, 407 St John Street, London EC1 V 4AD, UK.
authors.forename: Peter W M
authors.initials: PW
authors.lastname: Johnson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003299:Cooperative Behavior; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D057285:Precision Medicine / Q000379:methods; D006113:United Kingdom
chemical_list: D000970:Antineoplastic Agents