title: Animal Models and "Omics" Technologies for Identification of Novel Biomarkers and Drug Targets to Prevent Heart Failure.
abstract: It is now accepted that heart failure (HF) is a complex multifunctional disease rather than simply a hemodynamic dysfunction. Despite its complexity, stressed cardiomyocytes often follow conserved patterns of structural remodelling in order to adapt, survive, and regenerate. When cardiac adaptations cannot cope with mechanical, ischemic, and metabolic loads efficiently or become chronically activated, as, for example, after infection, then the ongoing structural remodelling and dedifferentiation often lead to compromised pump function and patient death. It is, therefore, of major importance to understand key events in the progression from a compensatory left ventricular (LV) systolic dysfunction to a decompensatory LV systolic dysfunction and HF. To achieve this, various animal models in combination with an "omics" toolbox can be used. These approaches will ultimately lead to the identification of an arsenal of biomarkers and therapeutic targets which have the potential to shape the medicine of the future.
authors.affiliation: Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Adrian-Segarra
authors.affiliation: Department of Cardiac Surgery, Kerckhoff Clinic, Benekestrasse 2-8, 61231 Bad Nauheim, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Richter
authors.affiliation: Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.
authors.forename: Natalia
authors.initials: N
authors.lastname: Kubin
authors.affiliation: Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.
authors.forename: Jaeyoung
authors.initials: J
authors.lastname: Shin
authors.affiliation: Department of Thoracic and Cardiac Surgery, Goethe University Frankfurt am Main, 60323 Frankfurt am Main, Germany.
authors.forename: Isabella
authors.initials: I
authors.lastname: Werner
authors.affiliation: Department of Cardiac Surgery, Kerckhoff Clinic, Benekestrasse 2-8, 61231 Bad Nauheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Walther
authors.affiliation: Department of Cardiac Surgery, Kerckhoff Clinic, Benekestrasse 2-8, 61231 Bad Nauheim, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Schönburg
authors.affiliation: Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany ; Department of Cardiac Surgery, Schüchtermann-Clinic, Ulmenallee 11, 49214 Bad Rothenfelde, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Pöling
authors.affiliation: Department of Cardiac Surgery, Schüchtermann-Clinic, Ulmenallee 11, 49214 Bad Rothenfelde, Germany ; University of Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Warnecke
authors.affiliation: Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Braun
authors.affiliation: Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.
authors.forename: Sawa
authors.initials: S
authors.lastname: Kostin
authors.affiliation: Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kubin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006333:Heart Failure / Q000517:prevention & control*; D006801:Humans; D055432:Metabolomics; D040901:Proteomics
chemical_list: D015415:Biomarkers