title: Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation.
abstract: Biodegradable and star-shaped polymers with highly tunable structure and properties have attracted much attention in recent years for potential biomedical applications, due to their special structure. Here, inositol-based star-shaped poly-L-lactide-poly(ethylene glycol) (INO-PLLA-PEG) biomedical polymer implants were for the first time synthesized by a facile photo-crosslinking method. This biomaterials show controlled elastomeric mechanical properties (~18 MPa in tensile strength, ~200 MPa in modulus, ~200% in elongation), biodegradability and osteoblasts biocompatibility. These results make INO-PLLA-PEG implants highly promising for bone tissue regeneration and drug delivery applications.
authors.affiliation: Frontier Institute of Science and Technology, Xi׳an Jiaotong University, Xi׳an, China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Xie
authors.affiliation: Frontier Institute of Science and Technology, Xi׳an Jiaotong University, Xi׳an, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Ge
authors.affiliation: Frontier Institute of Science and Technology, Xi׳an Jiaotong University, Xi׳an, China.
authors.forename: Yumeng
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Frontier Institute of Science and Technology, Xi׳an Jiaotong University, Xi׳an, China.
authors.forename: Yuzhang
authors.initials: Y
authors.lastname: Du
authors.affiliation: Frontier Institute of Science and Technology, Xi׳an Jiaotong University, Xi׳an, China; State Key Laboratory for Manufacturing Systems Engineering, Xi׳an Jiaotong University, Xi׳an, China; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China. Electronic address: rayboo@xjtu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Lei
authors.affiliation: Frontier Institute of Science and Technology, Xi׳an Jiaotong University, Xi׳an, China; Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, USA; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, USA. Electronic address: mapx@umich.edu.
authors.forename: Peter X
authors.initials: PX
authors.lastname: Ma
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D020724:Elastomers / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007294:Inositol / Q000737:chemistry*; D007773:Lactates / Q000737:chemistry; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020724:Elastomers; D007773:Lactates; C088513:poly(lactic acid-ethylene glycol); D014867:Water; D011092:Polyethylene Glycols; D007294:Inositol
keywords: Biocompatibility; Biodegradation; Biomedical materials; Highly tunable mechanical properties; Photo-crosslinking; Star-shaped polymers