title: A Versatile Organocatalytic Approach for the Synthesis of Enantioenriched gem-Difluorinated Compounds.
abstract: The combination of a practical and highly enantioselective organocatalytic reaction, which allows the stereoselective introduction of a benzodithiol group, with a fluorination step, gives a new and effective strategy for the stereoselective synthesis of difluorinated building blocks. The benzodithiol group is a versatile and chameleonic group that can be further functionalized before fluorination, giving customized and tailored useful synthetic strategies. As an example of the application of this facile strategy, the effective enantioselective synthesis of difluoroarundic acid is described.
authors.affiliation: Dipartimento di Chimica "G. Ciamician", ALMA MATER STUDIORUM, Università di Bologna, Via A. Selmi 2, 40126, Bologna (Italy).
authors.forename: Steve
authors.initials: S
authors.lastname: Saulnier
authors.affiliation: Dipartimento di Chimica "G. Ciamician", ALMA MATER STUDIORUM, Università di Bologna, Via A. Selmi 2, 40126, Bologna (Italy).|Université catholique de Louvain, Institute of Condensed Matter and Nanosciences, Croix du Sud, 1 bte L7.04.02, room a.241, 1348 Louvain-la-Neuve (Belgium).
authors.forename: Moira
authors.initials: M
authors.lastname: Ciardi
authors.affiliation: Dipartimento di Chimica "G. Ciamician", ALMA MATER STUDIORUM, Università di Bologna, Via A. Selmi 2, 40126, Bologna (Italy).
authors.forename: Veronica
authors.initials: V
authors.lastname: Lopez-Carrillo
authors.affiliation: Dipartimento di Chimica "G. Ciamician", ALMA MATER STUDIORUM, Università di Bologna, Via A. Selmi 2, 40126, Bologna (Italy).
authors.forename: Andrea
authors.initials: A
authors.lastname: Gualandi
authors.affiliation: Dipartimento di Chimica "G. Ciamician", ALMA MATER STUDIORUM, Università di Bologna, Via A. Selmi 2, 40126, Bologna (Italy). piergiorgio.cozzi@unibo.it.
authors.forename: Pier Giorgio
authors.initials: PG
authors.lastname: Cozzi
keywords: aldehydes; alkylation; enantioselectivity; fluorine; organocatalysis