title: Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor.
abstract: Mediastinal paragangliomas are rare neural crest derived tumors that may produce symptoms of excess catecholamine production or mass effect. Paragangliomas can histologically mimic neuroendocrine tumors. Further, both can arise in similar locations. We report a patient who presented with a right upper lobe as well as middle mediastinal lesion. Preoperative biopsy as well as intraoperative frozen section of these lesions failed to distinguish between paraganlioma or neuroendocrine tumor, necessitating a right upper lobectomy and complete mediastinal lymphadenectomy. Final pathology revealed carcinoid tumorlets in the right upper lobe and a middle mediastinal paraganglioma.
authors.affiliation: Department of Surgery, Division of Thoracic Surgery, Northwestern Memorial Hospital, Chicago, Illinois.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Mehta
authors.affiliation: Department of Medicine, Division of Pulmonary & Critical Care Medicine, Northwestern Memorial Hospital, Chicago, Illinois.
authors.forename: Colin T
authors.initials: CT
authors.lastname: Gillespie
authors.affiliation: Department of Pathology, Northwestern Memorial Hospital, Chicago, Illinois.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Pathology, Northwestern Memorial Hospital, Chicago, Illinois.
authors.forename: Anjana
authors.initials: A
authors.lastname: Yeldandi
authors.affiliation: Department of Surgery, Division of Thoracic Surgery, Northwestern Memorial Hospital, Chicago, Illinois.
authors.forename: Malcolm
authors.initials: M
authors.lastname: DeCamp
authors.affiliation: Department of Surgery, Division of Thoracic Surgery, Northwestern Memorial Hospital, Chicago, Illinois. Electronic address: abharat@nmh.org.
authors.forename: Ankit
authors.initials: A
authors.lastname: Bharat
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008479:Mediastinal Neoplasms / Q000473:pathology* / Q000556:secondary*; D018358:Neuroendocrine Tumors / Q000473:pathology* / Q000556:secondary*; D010235:Paraganglioma / Q000473:pathology*