title: [Bacteremia due to Rothia mucilaginosa after chemotherapy for myeloid malignancies].
abstract: The number of reported cases of bacteremia due to Rothia mucilaginosa (R. mucilaginosa), a component of the normal flora of human gastrointestinal tract mucosa, is limited. We encountered three cases of bacteremia due to R. mucilaginosa during neutropenia after chemotherapy for myeloid malignancies. Although all three patients were successfully treated with antimicrobial agents, one patient developed disseminated lesions in the lungs and soft tissue. The portal of R. mucilaginosa bacteremia is reportedly mucositis or dental disorders; however, no such complications were identified in our patients. Even in the absence of a preexisting portal, R. mucilaginosa should be recognized as a potential causative pathogen of bacteremia during neutropenic periods. Accumulations of cases and isolates are required to further elucidate the risk factors for developing R. mucilaginosa bacteremia, its clinical course, and the optimal antimicrobial treatment.
authors.affiliation: Division of Hematology, Department of Medicine, Keio University School of Medicine.
authors.forename: Sumiko
authors.initials: S
authors.lastname: Kohashi
authors.forename: Takehiko
authors.initials: T
authors.lastname: Mori
authors.forename: Yuya
authors.initials: Y
authors.lastname: Koda
authors.forename: Taku
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Jun
authors.initials: J
authors.lastname: Kato
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shimizu
authors.forename: Kayoko
authors.initials: K
authors.lastname: Sugita
authors.forename: Naoki
authors.initials: N
authors.lastname: Hasegawa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Murata
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Okamoto
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D019046:Bone Marrow Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008835:Micrococcaceae / Q000302:isolation & purification*; D008875:Middle Aged; D012509:Sarcoma / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents