title: Advancements in Pharmacotherapy for Noncancerous Manifestations of HPV.
abstract: Human papillomavirus (HPV) is the most common sexually transmitted disease. Via infection of the basal epithelial cells, HPV causes numerous malignancies and noncancerous cutaneous manifestations. Noncancerous cutaneous manifestations of HPV, including common, plantar, plane, and anogenital warts, are among the most common reasons for an office visit. Although there are various therapies available, they are notoriously difficult to treat. HPV treatments can be grouped into destructive (cantharidin, salicylic acid), virucidal (cidofovir, interferon-α), antimitotic (bleomycin, podophyllotoxin, 5-fluorouracil), immunotherapy (Candida antigen, contact allergen immunotherapy, imiquimod) or miscellaneous (trichloroacetic acid, polyphenon E). The mechanism of action, recent efficacy data, safety profile and recommended regimen for each of these treatment modalities is discussed.
authors.affiliation: Center for Clinical Studies, Houston 77004, TX, USA. rkollipara@ccstexas.com.
authors.forename: Ramya
authors.initials: R
authors.lastname: Kollipara
authors.affiliation: Department of Dermatology, the University of Texas Health Science Center at Houston, Houston 77030, TX, USA. Erfon.Ekhlassi@uth.tmc.edu.
authors.forename: Erfon
authors.initials: E
authors.lastname: Ekhlassi
authors.affiliation: Center for Clinical Studies, Houston 77004, TX, USA. cdowning@ccstexas.com.
authors.forename: Christopher
authors.initials: C
authors.lastname: Downing
authors.affiliation: Center for Clinical Studies, Houston 77004, TX, USA. jguidry@ccstexas.com.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Guidry
authors.affiliation: Center for Clinical Studies, Houston 77004, TX, USA. mlee@ccstexas.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Lee
authors.affiliation: Center for Clinical Studies, Houston 77004, TX, USA. Erfon.Ekhlassi@uth.tmc.edu.|Department of Dermatology, the University of Texas Health Science Center at Houston, Houston 77030, TX, USA. Erfon.Ekhlassi@uth.tmc.edu.
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Tyring
keywords: HPV; condyloma; pharmacotherapy; treatment; warts