title: Strategic Application of Residence-Time Control in Continuous-Flow Reactors.
abstract: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.
authors.forename: István M
authors.initials: IM
authors.lastname: Mándity
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary ; MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences Eötvös u. 6, H-6720, Szeged, Hungary.
authors.forename: Sándor B
authors.initials: SB
authors.lastname: Ötvös
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary ; MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences Eötvös u. 6, H-6720, Szeged, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Fülöp
keywords: chemoselectivity; continuous flow; diastereoselectivity; reactors; residence time