title: Renal Vein Thrombosis in a Newborn With Abnormal Factor VIII Level: Clinical Case Report.
abstract: Renal vein thrombosis (RVT) in neonates is a rare condition of low mortality but significant morbidity due to renal impairment.We report the case of a male term newborn with left RVT and elevated serum factor VIII (FVIII).The main symptoms of the patient and the important clinical findings: prompt diagnosis of RVT was possible because the classic clinical presentation of macroscopic hematuria, thrombocytopenia, and palpable flank mass were present in this newborn infant.The main diagnoses: finally, the reason of RVT was established when the infant was 3 months of age: the increased level of FVIII was confirmed. We discuss the diagnosis, therapy, and outcome of the patient and compare with the literature.Therapeutics interventions: however, despite anticoagulant therapy the left kidney developed areas of scarring and then atrophy.Conclusions and outcomes: Prothrombotic defects should be considered in all patients with perinatal RVT. Elevated factor VIII as a reason of RVT in neonatal period is particularly rare. Given a poor renal outcome in children associated with elevated levels of factor VIII, consideration could be given to more aggressive antithrombotic therapy in such cases.
authors.affiliation: From the Department of Neonatology (AS, AP, BKO); and Department of Pediatric Nephrology, Wroclaw Medical University, Wroclaw, Poland (KK).
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szafranska
authors.forename: Agata
authors.initials: A
authors.lastname: Pajak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kilis-Pstrusinska
authors.forename: Barbara
authors.initials: B
authors.lastname: Królak-Olejnik
mesh_terms: D015415:Biomarkers / Q000097:blood; D005169:Factor VIII / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012082:Renal Veins; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis*; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology*
chemical_list: D015415:Biomarkers; D005169:Factor VIII