title: Effects of different periods of gastric ischaemia in the viability of the tissue of body, fundus and antrum region of rabbit stomach.
abstract: BACKGROUND
  Despite the rich vascular arcade of the stomach, gastric ischemia represents an important medical challenge and can be the consequence of obstructive or non-obstructive vascular processes of pathological or iatrogenic origin.
  
  
  OBJECTIVE
  To assess the effects of acute gastric ischaemia on the different regions of the stomach.
  
  
  METHODS
  Fifteen New Zeland rabbits were divided into three groups: group 1, animals were observed during 3 h; group 2, during 6 h; group 3, during 12 h. Rabbit stomachs were subjected to devascularization of the greater and lesser curvatures. After predetermined time, the stomachs were removed for macro and microscopic studies.
  
  
  RESULTS
  Haemorrhagic necrosis was more marked in the gastric fundus and body. In contrast, the antropylorus remained preserved in 80% of the animals. Necrosis of the gastric body and fundus mucosa were observed in all animals after 6 h and 12 h of ischaemia.
  
  
  CONCLUSIONS
  Acute gastric ischaemia in rabbits produces haemorrhagic necrosis of the gastric fundus and body even in a short period of time. Beside this, the antropyloric region was significantly more resistant to ischaemia.
authors.affiliation: Department of Pathology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Maria Angélica B
authors.initials: MA
authors.lastname: Magalhães
authors.affiliation: Department of Pathology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Alfredo J A
authors.initials: AJ
authors.lastname: Barbosa
authors.affiliation: Department of Surgery, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Juliano A
authors.initials: JA
authors.lastname: Figueiredo
authors.affiliation: Department of Surgery, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Luiz R
authors.initials: LR
authors.lastname: Alberti
authors.affiliation: Department of Surgery, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Andy
authors.initials: A
authors.lastname: Petroianu
mesh_terms: D000208:Acute Disease; D000818:Animals; D007511:Ischemia / Q000473:pathology*; D008297:Male; D011817:Rabbits; D013270:Stomach / Q000098:blood supply* / Q000473:pathology*; D014022:Tissue Survival