title: In situ synthesis of new magnetite chitosan/carrageenan nanocomposites by electrostatic interactions for protein delivery applications.
abstract: We present a simple method to develop magnetite chitosan/carrageenan nanocomposites by in situ synthesis under mild conditions, and then their potential for controlled release of macromolecules was also evaluated. The structural, morphological and magnetic properties of the as-prepared materials were studied by vibrating sample magnetometer, X-ray diffractometer, Fourier transform infrared spectroscopy, thermogravimetric analyzer and transmission electron microscopy. With the varying mass ratio (chitosan to Fe3O4-carrageenan nanocomposite), the developed nanocarriers presented sizes within 73-355nm and zeta potentials of -42-32mV. Using bovine serum albumin as model protein, the adsorption and release behaviors were investigated. Nanocarriers evidenced excellent loading capacity of 181mgg(-1) at protein concentration of 0.2mgmL(-1), and demonstrated capacity to provide a sustained release up to 85% of adsorbed protein in 30min in intestinal medium rather than acidic medium. These results suggest that the developed magnetite chitosan/carrageenan nanocomposites are promising in the application of magnetically targeted delivery of therapeutic macromolecules.
authors.affiliation: The State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Long
authors.affiliation: The State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Yu
authors.affiliation: The State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China.
authors.forename: Enbo
authors.initials: E
authors.lastname: Xu
authors.affiliation: The State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China.
authors.forename: Zhengzong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: The State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China.
authors.forename: Xueming
authors.initials: X
authors.lastname: Xu
authors.affiliation: The State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China. Electronic address: jinlab2008@yahoo.com.
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Jin
authors.affiliation: The State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China. Electronic address: jiaoaq@jiangnan.edu.cn.
authors.forename: Aiquan
authors.initials: A
authors.lastname: Jiao
mesh_terms: D000327:Adsorption; D000818:Animals; D002351:Carrageenan / Q000138:chemical synthesis* / Q000737:chemistry; D002417:Cattle; D048271:Chitosan / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000138:chemical synthesis*; D007700:Kinetics; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D012710:Serum Albumin, Bovine; D002351:Carrageenan; D048271:Chitosan; D052203:Ferrosoferric Oxide
keywords: Controlled release; Electrostatic interactions; In situ synthesis; Magnetite chitosan/carrageenan nanocomposites