title: The gut microbiota in human energy homeostasis and obesity.
abstract: Numerous studies of rodents suggest that the gut microbiota populations are sensitive to genetic and environmental influences, and can produce or influence afferent signals that directly or indirectly impinge on energy homeostatic systems affecting both energy balance (weight gain or loss) and energy stores. Fecal transplants from obese and lean human, and from mouse donors to gnotobiotic mice, result in adoption of the donor somatotype by the formerly germ-free rodents. Thus, the microbiota is certainly implicated in the development of obesity, adiposity-related comorbidities, and the response to interventions designed to achieve sustained weight reduction in mice. More studies are needed to determine whether the microbiota plays a similarly potent role in human body-weight regulation and obesity.
authors.affiliation: Columbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY 10032, USA. Electronic address: mr475@cumc.columbia.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Rosenbaum
authors.affiliation: Departments of Pediatrics and Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Rob
authors.initials: R
authors.lastname: Knight
authors.affiliation: Columbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY 10032, USA.
authors.forename: Rudolph L
authors.initials: RL
authors.lastname: Leibel
mesh_terms: D050154:Adiposity; D000818:Animals; D004734:Energy Metabolism; D000069196:Gastrointestinal Microbiome; D006801:Humans; D009765:Obesity / Q000378:metabolism* / Q000382:microbiology*