title: Serum neutrophil-to-lymphocyte ratio in retinopathy of prematurity.
abstract: OBJECTIVE
  To evaluate the relationship between serum neutrophil-to-lymphocyte ratio (NLR) and development of retinopathy of prematurity (ROP).
  
  
  METHODS
  Infants with a gestational age of ≤32 week were screened for ROP. Complete blood cell, high-sensitivity C-reactive protein, and interleukin 6 levels of subjects were measured within the first 24 hours of life. The NLR was calculated by dividing neutrophil count by lymphocyte count. The association between other risk factors and the development of ROP were analyzed using univariate analysis and multivariate logistic regression analysis.
  
  
  RESULTS
  A total of 100 infants were included: 80 with ROP and 20 without ROP. The NLR values differed significantly between the ROP group (median, 0.67; interquartile range, 0.38-1.09) and non-ROP group (median, 0.32; interquartile range, 0.22-0.79; P = 0.02). The lymphocyte count in the ROP group (4.01 ± 1.89) compared to that of the non-ROP group (5.69 ± 2.16) was significantly lower (P = 0.001). In multivariate analysis, lymphocyte count remained an independent predictor of ROP (OR = 0.599; 95% CI, 0.430-0.836; P = 0.003).
  
  
  CONCLUSIONS
  The NLR seems not to be an independent predictor of development of ROP. Lymphocyte count is inversely associated with ROP.
authors.affiliation: Department of Ophthalmology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey. Electronic address: becekurtul@gmail.com.
authors.forename: Bengi Ece
authors.initials: BE
authors.lastname: Kurtul
authors.affiliation: Department of Ophthalmology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
authors.forename: Emrah Utku
authors.initials: EU
authors.lastname: Kabatas
authors.affiliation: Department of Neonatology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Zenciroglu
authors.affiliation: Department of Ophthalmology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
authors.forename: Pinar Altiaylik
authors.initials: PA
authors.lastname: Ozer
authors.affiliation: Department of Ophthalmology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
authors.forename: Gokce Tasdemir
authors.initials: GT
authors.lastname: Ertugrul
authors.affiliation: Department of Neonatology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Beken
authors.affiliation: Department of Neonatology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
authors.forename: Nurullah
authors.initials: N
authors.lastname: Okumus
mesh_terms: D001724:Birth Weight; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D015850:Interleukin-6 / Q000097:blood; D017075:Laser Coagulation; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D015997:Neonatal Screening; D009504:Neutrophils / Q000276:immunology*; D012178:Retinopathy of Prematurity / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D012307:Risk Factors
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein