title: Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test.
abstract: Some reports suggest that older patients are less responsive to antidepressants than young adults, but this idea has not been fully supported. Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in young adults (3-5 months), middle-aged (MA, 12-15 months), and senescent (SE, 23-25 months) male rats in the forced-swim test. In addition, locomotor activity and motor coordination were assessed as side-effects. DMI and fluoxetine produced an antidepressant-like effect in YA and MA animals, although in the latter group, a shift to the right in the dose-response curve was found for DMI. Importantly, neither drug was effective in SE animals. Motor side-effects were produced mainly by DMI in MA and SE rats. Therefore, a decrease in the antidepressant-like effect is associated strongly with senescence as well as an increased vulnerability to motor side-effects, particularly of tricyclics. This study is significant because SE animals are scarcely studied in pharmacological screening tests, and our findings might be useful for improving antidepressant treatments for the increasing aged population.
authors.affiliation: aDepartment of Neuroscience Research, National Institute of Psychiatry Ramon de la Fuente Muñiz bDepartment of Pharmacobiology, Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexico.
authors.forename: Maribel
authors.initials: M
authors.lastname: Olivares-Nazario
authors.forename: Alonso
authors.initials: A
authors.lastname: Fernández-Guasti
authors.forename: Lucía
authors.initials: L
authors.lastname: Martínez-Mota
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology / Q000523:psychology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology*; D003891:Desipramine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011897:Random Allocation; D017208:Rats, Wistar; D045442:Rotarod Performance Test; D013550:Swimming / Q000502:physiology / Q000523:psychology
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D003891:Desipramine