title: Biomineralization of hydroxyapatite in silver ion-exchanged nanocrystalline ZSM-5 zeolite using simulated body fluid.
abstract: Silver ion-exchanged nanocrystalline zeolite (Ag-Nano-ZSM-5) and silver ion-exchanged conventional zeolite (Ag-ZSM-5) were synthesized. Zeolites were incubated in simulated body fluid at 310K for different time periods to grow hydroxyapatite in their matrixes. Significant large amount of hydroxyapatite was grown in Ag-Nano-ZSM-5 matrix after incubation in simulated body fluid when compared to Ag-ZSM-5. The resultant material was characterized using X-ray diffraction, N2-adsorption, scanning/transmission electron microscopy, energy dispersive X-ray, and inductively coupled plasma analysis. Mechanical properties such as compressive modulus, compressive strength, and strain at failure of the parent materials were evaluated. Biocompatibility assays suggested that Ag-Nano-ZSM-5 and hydroxyapatite grown in Ag-Nano-ZSM-5 were compatible and did not impose any toxicity to RAW 264.7 cells macrophase and Caco2 cells suggesting considerable potential for biomedical applications such as bone implants.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar 140001, India.
authors.forename: Balwinder
authors.initials: B
authors.lastname: Kaur
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar 140001, India. Electronic address: rajendra@iitrpr.ac.in.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Srivastava
authors.affiliation: Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700 064, India.
authors.forename: Biswarup
authors.initials: B
authors.lastname: Satpati
authors.affiliation: National Agri-Food Biotechnology Institute (NABI), SAS Nagar, Punjab, India.
authors.forename: Kanthi Kiran
authors.initials: KK
authors.lastname: Kondepudi
authors.affiliation: National Agri-Food Biotechnology Institute (NABI), SAS Nagar, Punjab, India.
authors.forename: Mahendra
authors.initials: M
authors.lastname: Bishnoi
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D018938:Caco-2 Cells; D002470:Cell Survival; D064595:Composite Tissue Allografts / Q000737:chemistry; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D007474:Ion Exchange; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity; D000067996:RAW 264.7 Cells; D012834:Silver / Q000737:chemistry* / Q000633:toxicity; D017641:Zeolites / Q000737:chemistry* / Q000633:toxicity
chemical_list: C570564:ZSM-5 zeolite; D017641:Zeolites; D012834:Silver; D017886:Durapatite
keywords: Bio nanocomposite; Bioactivity; Hydroxyapatite; Nanocrystalline zeolite; Simulated body fluid