title: [Parkinson's disease associated with a mutation in the PARK2 gene].
abstract: The most common cause of monogenic hereditary Parkinson's disease is a mutation in the PARK2 gene. Early onset, slow progression, dystonia, and good response to levodopa are typical of the disease phenotype. Finnish PARK2 patients have not been described previously. We describe two patients, in whom pathogenic mutations in the PARK2 gene were the cause of parkinsonism.
authors.forename: Valtteri
authors.initials: V
authors.lastname: Kaasinen
authors.forename: Marja
authors.initials: M
authors.lastname: Hietala
authors.forename: Mikko
authors.initials: M
authors.lastname: Kuoppamäki
mesh_terms: D017668:Age of Onset; D018450:Disease Progression; D005387:Finland; D005838:Genotype; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D009154:Mutation; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics*; D010641:Phenotype; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: D007980:Levodopa; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein