title: Molecular Imaging in the College of Optical Sciences - An Overview of Two Decades of Instrumentation Development.
abstract: During the past two decades, researchers at the University of Arizona's Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA ; Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: Lars R
authors.initials: LR
authors.lastname: Furenlid
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA ; Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: Harrison H
authors.initials: HH
authors.lastname: Barrett
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA ; Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: H Bradford
authors.initials: HB
authors.lastname: Barber
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA ; Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: Eric W
authors.initials: EW
authors.lastname: Clarkson
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA ; Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Kupinski
authors.affiliation: Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: Gail D
authors.initials: GD
authors.lastname: Stevenson
authors.affiliation: Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Woolfenden
keywords: CT; PET; SPECT; collimation; detectors; estimation; instrumentation; molecular imaging; reconstruction