title: Cu-mediated direct regioselective C-2 chlorination of indoles.
abstract: Cu-mediated C-2 chlorination of indoles was accomplished with copper(ii) chloride through the use of a directing pyrimidyl protection group. A highly regioselective manner can be achieved on a range of indole substrates with excellent functional group tolerance.
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China. chaojiang@njust.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiuzhi
authors.initials: X
authors.lastname: Cheng
authors.forename: Jun
authors.initials: J
authors.lastname: Le
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Fengtian
authors.initials: F
authors.lastname: Xue
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Jiang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D003300:Copper; C030374:indole