title: Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB.
abstract: The molecular clock is a master controller of circadian cellular processes that affect growth, metabolic homeostasis, and behavior. A report in Science by Zhang et al. (2015) redefines our understanding of how Rev-erba acts as an internal feedback inhibitor that modulates activity of the core clock while simultaneously regulating tissue-specific metabolic processes.
authors.affiliation: Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Butler
authors.affiliation: Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. Electronic address: burristp@slu.edu.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Burris
mesh_terms: D000818:Animals; D056926:CLOCK Proteins / Q000235:genetics*; D057906:Circadian Clocks / Q000235:genetics*; D002940:Circadian Rhythm / Q000235:genetics*; D005786:Gene Expression Regulation; D006655:Histone Deacetylases / Q000378:metabolism*; D008297:Male; D008660:Metabolism / Q000235:genetics*; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1 / Q000378:metabolism*
chemical_list: D056953:Nuclear Receptor Subfamily 1, Group D, Member 1; D056926:CLOCK Proteins; D006655:Histone Deacetylases