title: Validation of the Chinese version of EORTC QLQ-BM22 in patients with bone metastases.
abstract: OBJECTIVE
  Our aim is to test the validity, reliability, and acceptability of the Chinese version of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Bone Metastases 22 (EORTC QLQ-BM22) module to assess health-related quality of life (HRQOL) in patients with bone metastases in China.
  
  
  METHODS
  Patients with histological confirmation of malignancy and bone metastases from Tianjin Cancer Institution and Hospital from June 2013 to April 2014 were enrolled in this study. All patients self-administered the EORTC QLQ-BM22 and the EORTC QLQ-C30. The Karnofsky Performance Scale (KPS) was performed to evaluate scores. The reliability and validity tests of the questionnaires were based on Cronbach's α coefficients, Pearson correlation test, and Wilcoxon rank sum nonparametric test.
  
  
  RESULTS
  Internal consistency reliabilities of all the four scales were acceptable. Scales measuring similar HRQOL aspects were found to correlate with one another between EORTC QLQ-BM22 and EORTC QLQ-C30, but differences still existed. Significant differences were demonstrated in the scores of all four subscales of the QLQ-BM22 between the two KPS subgroups (KPS ≤ 80; KPS > 80). Meanwhile, the compliance for item completion of the QLQ-BM22 was satisfactory.
  
  
  CONCLUSIONS
  The Chinese version of EORTC QLQ-BM22 is a reliable and valid instrument, which is appropriate for measuring the HRQOL of patients with bone metastases in China.
authors.affiliation: Department of Thoracic Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin, 300060, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin, 300060, People's Republic of China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Su
authors.affiliation: Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Jia-Yue
authors.initials: JY
authors.lastname: Chen
authors.affiliation: Department of Bone and Softissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of China.
authors.forename: Zhi-Chao
authors.initials: ZC
authors.lastname: Liao
authors.affiliation: Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People's Republic of China.
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Luo
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.
authors.forename: Shu-Min
authors.initials: SM
authors.lastname: Xie
authors.affiliation: Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Yun-Shou
authors.initials: YS
authors.lastname: Lin
authors.affiliation: Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.affiliation: Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Sun
authors.affiliation: Erasmus University Rotterdam, Rotterdam, Netherlands.
authors.forename: Begüm
authors.initials: B
authors.lastname: Pekbay
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Adam R
authors.initials: AR
authors.lastname: Miller
authors.affiliation: Department of Radiation Oncology, Tumor Hospital Xiangya School of Medicine of Central South University, Changsha, People's Republic of China.
authors.forename: Le
authors.initials: L
authors.lastname: Luo
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Rui
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.
authors.forename: Mo-Han
authors.initials: MH
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin, 300060, People's Republic of China. 13189368@qq.com.
authors.forename: Chang-Li
authors.initials: CL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011788:Quality of Life; D011795:Surveys and Questionnaires; D054928:Validation Studies as Topic; D055815:Young Adult
chemical_list: D050071:Bone Density Conservation Agents
keywords: Bone metastases; EORTC QLQ-BM22; Health-related quality of life; Validation