title: Identify asthma genes across three phases based on protein-protein interaction network.
abstract: Asthma is a common inflammatory disease that is generally caused by genetic mutations or environmental factors. Recently, the emerging of omics data provides an alternative way to understand asthma. In this study, the authors present a new framework to detect asthma disease genes based on protein-protein interaction network (PPIN) and gene expression. Specifically, they construct PPINs for different stages of asthma, and detect those interactions occurred in the specific stages. By investigating the proteins in these stage-specific interactions, they find they are more likely related to asthma, and the functional enrichment analysis indicate that the pathways enriched in the differential interactions are related to the progress of asthma. Moreover, some proteins in the differential interactions have been previously reported to be related to asthma in the literature, implying the usefulness of the proposed approach.
authors.affiliation: ICU, The People's Hospital of Laiwu City, Snow Lake Avenue, Laiwu, Shandong Province, 271199, People's Republic of China.
authors.forename: Fengyong
authors.initials: F
authors.lastname: Yang
authors.affiliation: Emergency Department, The People's Hospital of Laiwu City, Snow Lake Avenue, Laiwu, Shandong Province, 271199, People's Republic of China.
authors.forename: Xianling
authors.initials: X
authors.lastname: Yu
authors.affiliation: ICU, The People's Hospital of Laiwu City, Snow Lake Avenue, Laiwu, Shandong Province, 271199, People's Republic of China.
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The People's Hospital of Laiwu City, Snow Lake Avenue, Laiwu, Shandong Province, 271199, People's Republic of China.
authors.forename: Lili
authors.initials: L
authors.lastname: Liu
authors.affiliation: Respiratory Medical Department, The People's Hospital of Laiwu City, Snow Lake Avenue, Laiwu, Shandong Province, 271199, People's Republic of China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Xu
authors.affiliation: Burn Center, Changhai Hospital affiliated to Second Military Medical University, Changhai Road, Shanghai, 200433, People's Republic of China.
authors.forename: Xingfeng
authors.initials: X
authors.lastname: Zheng
authors.affiliation: ICU, The People's Hospital of Laiwu City, Snow Lake Avenue, Laiwu, Shandong Province, 271199, People's Republic of China. wgchen6279078@126.com.
authors.forename: Guangchen
authors.initials: G
authors.lastname: Wei
mesh_terms: D000465:Algorithms; D001249:Asthma / Q000378:metabolism*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods*; D025941:Protein Interaction Mapping / Q000379:methods*; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020543:Proteome