title: Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats.
abstract: In this study, we investigated the cardioprotective effect of one purified polysaccharide (SMP1) from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. ISO-treated rats showed severe myocardial damage and high lipid peroxidation level, as well as decreased endogenous myocardial antioxidant function. Pretreatment with SMP1 (100 and 400mg/kg) for 30 days significantly increased the body weight, decreased the heart weight, attenuated the serum levels of creatine kinase (CK), creatine phospokinase-MB (CK-MB), dehydrogenase (LDH), alkaline phosphate (ALP), aspartate transaminase (AST), alanine transaminase (ALT), total cholesterol, triglyceride, and LDL-cholesterol (LDL-C), along with the increased concentration of HDL-cholesterol (HDL-C). In addition, SMP1 also enhanced myocardial superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities and elevated myocardial reduced glutathione (GSH) level, along with a decrease in thiobarbituric acid reactive substances (TBARS) concentration. Collectively, our results indicated that long-term oral administration of SMP1 offered significant protection against the damage induced by ISO in rat heart through enhancement of endogenous antioxidants and antihyperlipidemic activity.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital, Third Military Medical University, Xinzheng Street No. 183, Shapingba District, Chongqing 400037, China.
authors.forename: Zhao-Hua
authors.initials: ZH
authors.lastname: Geng
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital, Third Military Medical University, Xinzheng Street No. 183, Shapingba District, Chongqing 400037, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital, Third Military Medical University, Xinzheng Street No. 183, Shapingba District, Chongqing 400037, China.
authors.forename: Ming-Bao
authors.initials: MB
authors.lastname: Song
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital, Third Military Medical University, Xinzheng Street No. 183, Shapingba District, Chongqing 400037, China. Electronic address: mingysong@126.com.
authors.forename: Yao-Ming
authors.initials: YM
authors.lastname: Song
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D002316:Cardiotonic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003402:Creatine Kinase / Q000378:metabolism; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007545:Isoproterenol / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; D011134:Polysaccharides; D010088:Oxidoreductases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D005978:Glutathione; D007545:Isoproterenol
keywords: Antioxidants; Isoproterenol; Myocardial infarction; Polysaccharide; Salvia miltiorrhiza