title: Micrometer-sized network structure of novel DNA-lipid conjugates induced by heat stimulation.
abstract: We have developed a novel lipid-bearing DNA that forms hairpin modules, including a single RNA monomer; this can be used to create micrometer-sized structures from nanometer-sized building blocks during breakage at the RNA site. In the presence of divalent metal ions and heat stimulation, we observed transition of the self-assembly, which results in the formation of a three-dimensional network structure. To our knowledge, this is also the first report of heat-induced micrometer-sized molecular self-assembly of molecules that carry biological information.
authors.affiliation: Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan. cttoyota@mail.ecc.u-tokyo.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Matsuo
authors.forename: T
authors.initials: T
authors.lastname: Banno
authors.forename: T
authors.initials: T
authors.lastname: Toyota
mesh_terms: D004247:DNA / Q000737:chemistry*; D006358:Hot Temperature; D055029:Inverted Repeat Sequences; D008055:Lipids / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry; D012313:RNA / Q000737:chemistry
chemical_list: D008055:Lipids; D012313:RNA; D004247:DNA; D008274:Magnesium