title: Dissecting the cannabinergic control of behavior: The where matters.
abstract: The endocannabinoid system is the target of the main psychoactive component of the plant Cannabis sativa, the Δ(9)-tetrahydrocannabinol (THC). This system is composed by the cannabinoid receptors, the endogenous ligands, and the enzymes involved in their metabolic processes, which works both centrally and peripherally to regulate a plethora of physiological functions. This review aims at explaining how the site-specific actions of the endocannabinoid system impact on memory and feeding behavior through the cannabinoid receptors 1 (CB1 R). Centrally, CB1 R is widely distributed in many brain regions, different cell types (e.g. neuronal or glial cells) and intracellular compartments (e.g. mitochondria). Interestingly, cellular and molecular effects are differentially mediated by CB1 R according to their cell-type localization (e.g. glutamatergic or GABAergic neurons). Thus, understanding the cellular and subcellular function of CB1 R will provide new insights and aid the design of new compounds in cannabinoid-based medicine. Also watch the Video Abstract.
authors.affiliation: Group "Endocannabinoids and Neuroadaptation," NeuroCentre Magendie, INSERM U862, University of Bordeaux, Bordeaux, France.
authors.forename: Arnau
authors.initials: A
authors.lastname: Busquets-Garcia
authors.affiliation: Group "Endocannabinoids and Neuroadaptation," NeuroCentre Magendie, INSERM U862, University of Bordeaux, Bordeaux, France.
authors.forename: Tifany
authors.initials: T
authors.lastname: Desprez
authors.affiliation: Group "Endocannabinoids and Neuroadaptation," NeuroCentre Magendie, INSERM U862, University of Bordeaux, Bordeaux, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Metna-Laurent
authors.affiliation: Group "Endocannabinoids and Neuroadaptation," NeuroCentre Magendie, INSERM U862, University of Bordeaux, Bordeaux, France.
authors.forename: Luigi
authors.initials: L
authors.lastname: Bellocchio
authors.affiliation: Group "Endocannabinoids and Neuroadaptation," NeuroCentre Magendie, INSERM U862, University of Bordeaux, Bordeaux, France.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Marsicano
authors.affiliation: Group "Endocannabinoids and Neuroadaptation," NeuroCentre Magendie, INSERM U862, University of Bordeaux, Bordeaux, France.
authors.forename: Edgar
authors.initials: E
authors.lastname: Soria-Gomez
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology; D002188:Cannabis / Q000378:metabolism; D013759:Dronabinol / Q000494:pharmacology; D063388:Endocannabinoids / Q000378:metabolism*; D005247:Feeding Behavior / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008568:Memory / Q000502:physiology*; D051379:Mice; D009830:Olfactory Bulb / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism*; D043885:Receptor, Cannabinoid, CB2 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; D013759:Dronabinol
keywords: endocannabinoids; fear; food intake; memory; mitochondria