title: Uterus transplantation trial: Psychological evaluation of recipients and partners during the post-transplantation year.
abstract: OBJECTIVE
  To explore the psychology and well-being of the nine patients undergoing uterus transplantation (UTx) as part of the first clinical trial, during the first 12 months of which seven patients experienced graft survival with occasional mild rejection episodes and two patients experienced graft failure, with hysterectomy.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Nine female uterine recipients and their partners.
  
  
  METHODS
  Psychological evaluations by questionnaires focusing on quality of life, mood, relationship, and fertility quality of life were conducted at inclusion and at 3, 6, and 12 months after UTx.
  
  
  METHODS
  Scores of four different questionnaires regarding mood, quality of life, fertility quality of life, and relationship.
  
  
  RESULTS
  In all questionnaire domains, the recipients and their partners showed a similar pattern at baseline, and the UTx group, including both recipients and partners, scored similarly or better when compared with relevant norm groups. Among the recipients there was a reversible decline in score of physical activity and increased bodily pain at 3 months past surgery.
  
  
  CONCLUSIONS
  The results show that participants of this first UTx trial were psychologically stable both at baseline and during the first year, despite rejection episodes and possible worries about viability of graft.
  
  
  BACKGROUND
  ClinicalTrials.govNCT01844362.
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; Department of Psychology, University of Gothenburg, Göteborg, Sweden. Electronic address: stina.jarvholm@vgregion.se.
authors.forename: Stina
authors.initials: S
authors.lastname: Järvholm
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
authors.forename: Liza
authors.initials: L
authors.lastname: Johannesson
authors.affiliation: Department of Plastic and Reconstructive Surgery, Royal Free London, National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Alex
authors.initials: A
authors.lastname: Clarke
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Brännström
mesh_terms: D000328:Adult; D004644:Emotions; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007247:Infertility, Female / Q000523:psychology / Q000628:therapy; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011788:Quality of Life; D018454:Spouses / Q000523:psychology*; D011795:Surveys and Questionnaires; D066027:Transplant Recipients / Q000523:psychology*; D014599:Uterus / Q000637:transplantation*
keywords: Infertility; psychology; transplantation; uterus