title: Daughter's Tolerance of Mom Matters in Mate Choice.
abstract: Mendelian genetics presumes inheritance of fitness through DNA. Kinder et al. find that maternal microchimerism induces stable immune tolerance to non-inherited maternal antigens in offspring. Female offspring that share these antigens with their mate experience reduced fetal wasting, establishing a role for vertical transmission of non-genetic information in reproductive fitness.
authors.affiliation: Department of Pathology, University of Birmingham at Alabama, Birmingham, AL 35294 USA. Electronic address: jrsinger@uab.edu.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Singer
authors.affiliation: Department of Pathology, University of Birmingham at Alabama, Birmingham, AL 35294 USA. Electronic address: cweaver@uab.edu.
authors.forename: Casey T
authors.initials: CT
authors.lastname: Weaver
mesh_terms: D000818:Animals; D005260:Female; D005333:Fetus / Q000276:immunology*; D056084:Genetic Fitness; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D008322:Mammals / Q000502:physiology*; D011247:Pregnancy / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*