title: Cyclodextrin/dextran based hydrogels prepared by cross-linking with sodium trimetaphosphate.
abstract: Novel βCD-based hydrogels have been synthesized using sodium trimetaphosphate (STMP) as non-toxic reagent. Straightforward mixing of βCD with dextran and STMP in basic aqueous media led to hydrogels incorporating dextran chains, phosphate groups and βCD units. The hydrogels have been characterized by swelling measurements, XPS and (31)P NMR. The swelling ratio was correlated to the content in phosphated groups, which give a polyelectrolyte character to these hydrogels. The significant rise of the swelling ratio with the βCD content increase has been attributed to a decrease of the number of phosphate-based crosslinks, the βCD units playing the role of dangling ends in the tridimensional network. Their loading capacity and their release properties have been investigated for methylene blue and benzophenone in order to demonstrate their potentiality for drug delivery. Through different interaction mechanisms, electrostatic and inclusion complex interactions, these compounds are loaded with different efficiencies. The release involves deswelling, diffusion mechanisms and partition equilibrium.
authors.affiliation: Université Paris Est, ICMPE (UMR7182), CNRS, UPEC, F 94320 Thiais, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Wintgens
authors.affiliation: Université Paris Est, ICMPE (UMR7182), CNRS, UPEC, F 94320 Thiais, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Lorthioir
authors.affiliation: Université Paris Est, ICMPE (UMR7182), CNRS, UPEC, F 94320 Thiais, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubot
authors.affiliation: Université Paris Est, ICMPE (UMR7182), CNRS, UPEC, F 94320 Thiais, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Sébille
authors.affiliation: Université Paris Est, ICMPE (UMR7182), CNRS, UPEC, F 94320 Thiais, France. Electronic address: amiel@icmpe.cnrs.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Amiel
mesh_terms: D001577:Benzophenones / Q000008:administration & dosage; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003911:Dextrans / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D008751:Methylene Blue / Q000008:administration & dosage; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011122:Polyphosphates / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D003432:Cross-Linking Reagents; D003911:Dextrans; D004337:Drug Carriers; D004791:Enzyme Inhibitors; D020100:Hydrogels; D017319:Photosensitizing Agents; D011122:Polyphosphates; D047392:beta-Cyclodextrins; C047723:benzophenone; C009293:trimetaphosphoric acid; C031215:betadex; D008751:Methylene Blue
keywords: Cross-linking; Dextran; Hydrogel; Sodium trimetaphosphate; β-Cyclodextrin