title: Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection.
abstract: Chronic HCV infection comprises a broad spectrum of liver disease, ranging from no or minimal activity to active hepatitis that in time may progress to severe liver fibrosis, cirrhosis and hepatocellular carcinoma if left untreated. This review describes the impact of genetic variants of interleukin 28B (IL28B; also known as interferon-lambda 3), inosine triphosphate pyrophosphatase (ITPA) and patatin-like phospholipase domain-containing 3 (PNPLA3) on therapeutic outcome and liver disease severity in HCV-infected patients.
authors.affiliation: Department of Infectious Medicine, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10B, SE-413 46, Gothenburg, Sweden.
authors.forename: Karolina
authors.initials: K
authors.lastname: Rembeck
authors.affiliation: Department of Infectious Medicine, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10B, SE-413 46, Gothenburg, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Lagging
mesh_terms: D018450:Disease Progression; D014644:Genetic Variation / Q000235:genetics*; D016174:Hepacivirus / Q000472:pathogenicity; D006526:Hepatitis C / Q000235:genetics* / Q000821:virology; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008049:Lipase / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D011755:Pyrophosphatases / Q000235:genetics*; D000095022:Interferon Lambda; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent; D000097630:Inosine Triphosphatase
chemical_list: D007372:Interferons; D007378:Interleukins; D008049:Lipase; D008565:Membrane Proteins; D011755:Pyrophosphatases; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C533682:PNPLA3 protein, human; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent; C511829:ITPA protein, human; D000097630:Inosine Triphosphatase
keywords: HCV; IL28B; ITPA; ITPase; PNPLA3; genetic variant; histology; inosine triphosphate pyrophosphatase; interferon-λ; natural history; therapy