title: Identification of cancer-related genes and motifs in the human gene regulatory network.
abstract: The authors investigated the regulatory network motifs and corresponding motif positions of cancer-related genes. First, they mapped disease-related genes to a transcription factor regulatory network. Next, they calculated statistically significant motifs and subsequently identified positions within these motifs that were enriched in cancer-related genes. Potential mechanisms of these motifs and positions are discussed. These results could be used to identify other disease- and cancer-related genes and could also suggest mechanisms for how these genes relate to co-occurring diseases.
authors.affiliation: Center for Healthcare Studies, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, 633 N. Saint Clair, Chicago, IL 60611, USA.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Carson
authors.affiliation: Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200040, People's Republic of China.
authors.forename: Jianlei
authors.initials: J
authors.lastname: Gu
authors.affiliation: Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200040, People's Republic of China.
authors.forename: Guangjun
authors.initials: G
authors.lastname: Yu
authors.affiliation: Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200040, People's Republic of China. huilu.bioinfo@gmail.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Lu
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D052138:Genes, Neoplasm / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D059372:Nucleotide Motifs; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D014157:Transcription Factors