title: Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders.
abstract: Gastroesophageal reflux disease (GERD) and bile reflux gastritis (BRG) are common gastrointestinal (GI) disorders with unmet medical needs. Traditional Chinese medicine has long been used for the treatment of GERD and BRG whereas the ginger-containing formula Wendan decoction (WDD) targets homeostatic disturbances characterized by "reflux" and "gut-juice exposure" problems. Here we used WDD as a therapeutic tool to unravel the common pathogenesis of GI reflux disorders. Control clinical trials reporting the WDD-treated patients with GERD and BRG were included in this systematic review and meta-analysis. Outcome measurements were clinical efficacy defined by symptom relief with normal GI endoscopy, radiology, and pathology. Eventually, 33 studies involved 3253 participants (1351 vs. 1035 of the BRG in 20 publications, 449 vs. 418 of the GERD in 13 studies, and 194 vs. 159 of relapse rate in 6 trials). Pooled data showed a consistent therapeutic efficacy of WDD on BRG (OR = 6.00, 95%C = 4.68-7.69) and GERD (OR = 4.39, 95%CI = 2.72-7.07). The relapse rate was 12.4% for WDD, significantly lower than 44.0% for conventional therapies (OR = 0.14, 95%CI = 0.08-0.26). The consistent therapeutic efficacy of the single TCM formula on GERD and BRD indirectly indicates reflux as a common pathogenesis in reflux-associated GI disorders.
authors.affiliation: Center for Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ling
authors.affiliation: Center for Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.|Department of Traditional Chinese Medicine, Guigang Hospital of Traditional Chinese Medicine, Guigang 537100, Guangxi, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Center for Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.|Department of Traditional Chinese Medicine, Fangchenggang Hospital of Traditional Chinese Medicine, Fangchenggang 538021, Guangxi, China.
authors.forename: Jia-Hua
authors.initials: JH
authors.lastname: Xu
authors.affiliation: Center for Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.|Department of Gastroenterology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center for Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Huang
authors.affiliation: Center for Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.|Department of Orthopedics, People Hospital of Rong County, Rong Xian 637500, Guangxi, China.
authors.forename: Hai-Bing
authors.initials: HB
authors.lastname: Ling
authors.affiliation: Guangdong Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sui
authors.affiliation: Center for Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors.forename: Hai-Lu
authors.initials: HL
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001655:Bile Reflux / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; C528423:wendan
keywords: Bile Reflux Gastritis; Duodenogastric Reflux; Gastroesophageal Reflux Disease; Reflux Esophagitis; Traditional Chinese Medicine; Wendan Decoction