title: Long-term abdominal adiposity activates several parameters of cardiac energy function.
abstract: Abdominal obesity increases the incidence of cardiac events but reduces mortality when one of these events occurs. The phenomenon called obesity paradox might be related to myocardial energetics. This study was aimed at determining whether long-term abdominal adiposity alters cardiac energy function. Two groups of male Wistar rats were fed a standard or a Western-type (WD) diet for 8 months. The ex vivo coronary reactivity and mechanical function as well as the mitochondrial oxidative phosphorylation (mOxPhos) and hydrogen peroxide release (mH2O2r) were determined. Abdominal adiposity was augmented by the WD. This was also the case for the coronary reactivity to acetylcholine, but the rate pressure product remained roughly stable despite a reduction of the left ventricle-developed pressure partly compensated by a slight increase in heart rate. The prolonged WD administration resulted in an improvement of mOxPhos, but the mH2O2r was exaggerated which was confirmed in the whole cell by a reduced aconitase to fumarase ratio. This did not modify the plasma oxidative stress due to an increased plasma antioxidant status. In conclusion, long-term WD administration improved the cardiac fitness and might predispose the organism to the obesity paradox. Conversely, the increased mitochondrial mH2O2r can precipitate the heart toward cardiomyopathy if the WD is maintained for a longer duration.
authors.affiliation: Laboratoire de Bioénergétique Fondamentale et Appliquée, INSERM U1055, 38041, Grenoble cedex 09, France.|Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier, 38041, Grenoble cedex 09, France.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Mourmoura
authors.affiliation: Unité de Nutrition Humaine, INRA, UMR 1019, Clermont Université, Université d'Auvergne, BP 10448, 63000, Clermont-Ferrand, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Rigaudière
authors.affiliation: Laboratoire de Bioénergétique Fondamentale et Appliquée, INSERM U1055, 38041, Grenoble cedex 09, France.|Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier, 38041, Grenoble cedex 09, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Couturier
authors.affiliation: Laboratoire de Bioénergétique Fondamentale et Appliquée, INSERM U1055, 38041, Grenoble cedex 09, France.|Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier, 38041, Grenoble cedex 09, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hininger
authors.affiliation: Unité de Nutrition Humaine, INRA, UMR 1019, Clermont Université, Université d'Auvergne, BP 10448, 63000, Clermont-Ferrand, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Laillet
authors.affiliation: Unité de Nutrition Humaine, INRA, UMR 1019, Clermont Université, Université d'Auvergne, BP 10448, 63000, Clermont-Ferrand, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Malpuech-Brugère
authors.affiliation: Clermont-Ferrand University Hospital, Heart Surgery Department, G. Montpied Hospital, 63000, Clermont-Ferrand, France.
authors.forename: Kasra
authors.initials: K
authors.lastname: Azarnoush
authors.affiliation: Laboratoire de Bioénergétique Fondamentale et Appliquée, INSERM U1055, 38041, Grenoble cedex 09, France. luc.demaison@clermont.inra.fr.|Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier, 38041, Grenoble cedex 09, France. luc.demaison@clermont.inra.fr.|Unité de Nutrition Humaine, INRA, UMR 1019, Clermont Université, Université d'Auvergne, BP 10448, 63000, Clermont-Ferrand, France. luc.demaison@clermont.inra.fr.
authors.forename: Luc
authors.initials: L
authors.lastname: Demaison
mesh_terms: D000154:Aconitate Hydratase / Q000378:metabolism; D050154:Adiposity; D000375:Aging; D052636:Allostasis; D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology* / Q000503:physiopathology; D066273:Diet, Western / Q000009:adverse effects; D018450:Disease Progression; D004734:Energy Metabolism; D005649:Fumarate Hydratase / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D056128:Obesity, Abdominal / Q000097:blood / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D010085:Oxidative Phosphorylation; D018384:Oxidative Stress; D011897:Random Allocation; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013610:Tachycardia / Q000209:etiology
chemical_list: D006861:Hydrogen Peroxide; D005649:Fumarate Hydratase; D000154:Aconitate Hydratase
keywords: Abdominal adiposity; Cardiac fitness; Obesity paradox; Western diet