title: Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.
abstract: Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8(+) T cells. There is strong in vivo evidence that the mouse XCR1(+) DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.
authors.affiliation: Laboratory of Phagocyte Immunobiology, Peter Gorer Department of Immunobiology, CMCBI, King's College London , London , UK.
authors.forename: Enric
authors.initials: E
authors.lastname: Gutiérrez-Martínez
authors.affiliation: Laboratory of Phagocyte Immunobiology, Peter Gorer Department of Immunobiology, CMCBI, King's College London , London , UK.
authors.forename: Remi
authors.initials: R
authors.lastname: Planès
authors.affiliation: Laboratory of Phagocyte Immunobiology, Peter Gorer Department of Immunobiology, CMCBI, King's College London , London , UK.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Anselmi
authors.affiliation: Laboratory of Phagocyte Immunobiology, Peter Gorer Department of Immunobiology, CMCBI, King's College London , London , UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Reynolds
authors.affiliation: Laboratory of Phagocyte Immunobiology, Peter Gorer Department of Immunobiology, CMCBI, King's College London , London , UK.
authors.forename: Shinelle
authors.initials: S
authors.lastname: Menezes
authors.affiliation: Laboratory of Phagocyte Immunobiology, Peter Gorer Department of Immunobiology, Centre for Molecular & Cellular Biology of Inflammation (CMCBI), King's College London , Paris , France ; Sorbonne Paris Cité, Université Paris Diderot , Paris , France.
authors.forename: Aimé Cézaire
authors.initials: AC
authors.lastname: Adiko
authors.affiliation: Laboratory of Phagocyte Immunobiology, Peter Gorer Department of Immunobiology, Centre for Molecular & Cellular Biology of Inflammation (CMCBI), King's College London , Paris , France ; Sorbonne Paris Cité, Université Paris Diderot , Paris , France.
authors.forename: Loredana
authors.initials: L
authors.lastname: Saveanu
authors.affiliation: Laboratory of Phagocyte Immunobiology, Peter Gorer Department of Immunobiology, CMCBI, King's College London , London , UK.
authors.forename: Pierre
authors.initials: P
authors.lastname: Guermonprez
keywords: MHC class I; antigen processing; cross-presentation; cross-priming; dendritic cells; phagocytosis