title: CML in pregnancy: A case report using leukapheresis and literature review.
abstract: Chronic myelogenous leukemia (CML) complicating pregnancy is uncommon. Literature search demonstrates only a few case reports and some case series but large studies are lacking due to its uncommon presentation. Management of these patients is particularly challenging due to limited available options as several chemotherapy drugs could potentially lead to adverse outcomes and fetal malformations. Leukapheresis has been used in these situations; however paucity of data exists regarding the outcome and complications associated with the procedure. Using leukapheresis alone for extended period to manage CML during pregnancy is also rare. Here we report a case of CML complicating pregnancy which was successfully managed utilizing leukapheresis, followed by a review of literature addressing this controversial issue.
authors.affiliation: Division of Hematology/Oncology, Stem Cell Transplantation, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Mahender
authors.initials: M
authors.lastname: Yellu
authors.affiliation: Department of Therapeutic Apheresis, Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Sue
authors.initials: S
authors.lastname: Pinkard
authors.affiliation: Division of Hematology/Oncology, Stem Cell Transplantation, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Abhimanyu
authors.initials: A
authors.lastname: Ghose
authors.affiliation: Division of Hematology/Oncology, Stem Cell Transplantation, University of Cincinnati, Cincinnati, OH, USA. Electronic address: medlinsn@ucmail.uc.edu.
authors.forename: Stephen
authors.initials: S
authors.lastname: Medlin
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*
keywords: CML; Chemotherapy; Leukapheresis; Pregnancy