title: Glucose, glycolysis and lymphocyte responses.
abstract: Activated lymphocytes engage in robust growth and rapid proliferation. To achieve this, they tend to adopt a form of glucose metabolism termed aerobic glycolysis. This type of metabolism allows for the use of large amounts of glucose to generate energy, but also to support biosynthetic processes. This review article will discuss how aerobic glycolysis supports the biosynthetic demands of activated T cells, B cells and Natural Killer cells, and the emerging concept that glycolysis is integrally linked to the differentiation and function of these lymphocyte populations.
authors.affiliation: School of Biochemistry and Immunology, and School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Donnelly
authors.affiliation: School of Biochemistry and Immunology, and School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. Electronic address: finlayd@tcd.ie.
authors.forename: David K
authors.initials: DK
authors.lastname: Finlay
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000378:metabolism*
chemical_list: D005947:Glucose
keywords: B cell; GAPDH; Galactose; Glucose; Glycolysis; Granzyme B; HIF1-α; IFNγ; Lymphocyte; Metabolism; Natural Killer cell; Oxidative phosphorylation; T cell; c-Myc; mTORC1; review