title: Sulcal morphology as a new imaging marker for the diagnosis of early onset Alzheimer's disease.
abstract: We investigated the utility of sulcal width measures in the diagnosis of Alzheimer's disease (AD). Sixty-six biologically confirmed AD patients (positive amyloid positron emission tomography [PET] and/or AD cerebrospinal fluid profile) were contrasted to 35 controls with negative amyloid PET. Patients were classified into prodromal or dementia stages as well as into late onset (LOAD, n = 31) or early onset (EOAD, n = 35) subgroups according to their age of onset. An automated method was used to calculate sulcal widths and hippocampal volumes (HV). In EOAD, the greatest ability to differentiate patients from age-matched controls, regardless of severity, was displayed by sulcal width of the temporoparietal cortex. In this region, diagnosis accuracy was better than the HV, especially at prodromal stage. In LOAD, HV provided the best discrimination power from age-matched controls. In conclusion, sulcal width measures are better markers than the HV for identifying prodromal AD in patients aged <65 years. In contrast, in older patients, the risk of over-diagnosis from using only sulcal enlargement is important.
authors.affiliation: Department of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, Paris, France. Electronic address: hamelin.lorraine@gmail.com.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Hamelin
authors.affiliation: Department of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, Paris, France; Department of Clinical Neurosiences, University of Cambridge, UK.
authors.forename: Maxime
authors.initials: M
authors.lastname: Bertoux
authors.affiliation: NeuroSpin, Institut d'Imagerie Biomédicale, Direction des sciences du vivant, Commissariat à l'Energie Atomique, Gif-sur-Yvette, France; Laboratoire Imagerie Moléculaire In Vivo, UMR 1023, Service Hospitalier Frédéric Joliot, Institut d'Imagerie Biomédicale, Direction des sciences du vivant, Commissariat à l'Energie Atomique, Orsay, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Bottlaender
authors.affiliation: Department of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Corne
authors.affiliation: Department of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Lagarde
authors.affiliation: Department of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Hahn
authors.affiliation: NeuroSpin, Institut d'Imagerie Biomédicale, Direction des sciences du vivant, Commissariat à l'Energie Atomique, Gif-sur-Yvette, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mangin
authors.affiliation: Institut du Cerveau et de la Moelle épinière, ICM, Paris, France; Department of Neurology, Salpêtrière Hospital, APHP, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Dubois
authors.affiliation: Institut du Cerveau et de la Moelle épinière, ICM, Paris, France; Inserm, U1127, Paris, France; CNRS, UMR 7225, ICM, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Paris, France; Inria, Aramis project-team, Centre de Recherche Paris-Rocquencourt, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Chupin
authors.affiliation: Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Leonardo Cruz
authors.initials: LC
authors.lastname: de Souza
authors.affiliation: Institut du Cerveau et de la Moelle épinière, ICM, Paris, France; Inserm, U1127, Paris, France; CNRS, UMR 7225, ICM, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Paris, France; Inria, Aramis project-team, Centre de Recherche Paris-Rocquencourt, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Colliot
authors.affiliation: Department of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Sarazin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Alzheimer's disease; MRI; Sulcal width