title: Constructing Failure: Leonard Hayflick, Biomedicine, and the Problems with Tissue Culture.
abstract: By examining the use of tissue culture in post-war American biomedicine, this paper investigates how scientists experience and manage failure. I study how Leonard Hayflick forged his new definition of failure and ways of managing it by refuting Alexis Carrel's definition of failure alongside his theory of the immortality of cultured cells. Unlike Carrel, Hayflick claimed that every vertebrate somatic cell should eventually die, unless it transformed into a tumour cell. This claim defined cell death, which had been a problem leading to a laboratory failure, as a normal phenomenon. On the other hand, permanent life, which had been considered a normal cellular characteristic, became a major factor causing scientific failure, since it implied malignant transformation that scientists hoped to control. Hayflick then asserted that his cell strains and method would partly enable scientists to manage this factor-especially that occurred through viral infection-alongside other causes of failure in routine tasks, including bacterial contamination. I argue that the growing biomedical enterprise fostered this work of Hayflick's, which had repercussions in both his career and the uses of cells in diverse investigations. His redefinition of failure in the age of biomedicine resulted in the broad dissemination of his cells, medium, and method as well as his long struggle with the National Institutes of Health (NIH), which caused his temporarily failed career.
authors.affiliation: a History Programme , Nanyang Technological University , Singapore.
authors.forename: Hyung Wook
authors.initials: HW
authors.lastname: Park
mesh_terms: D035843:Biomedical Research / Q000266:history; D016923:Cell Death; D002478:Cells, Cultured / Q000502:physiology*; D049673:History, 20th Century; D046509:Tissue Culture Techniques / Q000266:history*; D014481:United States
keywords: Leonard Hayflick; NIH; Tissue culture; biomedicine; failure