title: Pathogenesis and targeted treatment of skin injury in SLE.
abstract: Skin is the second most common organ (after the kidney) to be affected in patients with systemic lupus erythematosus (SLE), yet the aetiology of skin injury and the mechanisms involved in the development of dermal manifestations of SLE remain unclear. Ultraviolet light (UV), immune cells, cytokines and deposition of immunoglobulins all seem to have a role in the development of skin inflammation and damage in SLE. UV represents the most important environmental factor, and exposure to UV triggers the development of skin lesions in areas where immunoglobulin has been deposited and various other components of the immune system have accumulated. In addition, a number of intracellular kinases and transcription factors have also been demonstrated to be involved in the generation of skin lesions in lupus-prone mice. These molecules can be targeted by small-molecule inhibitors, leading to the prospect that treatments suitable for topical application, and with limited adverse effects, could be developed. Further studies to eliminate the burden of skin inflammation in patients with SLE are clearly required.
authors.affiliation: Key Laboratory of Antibody Technology of Ministry of Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, China.
authors.forename: Guo-Min
authors.initials: GM
authors.lastname: Deng
authors.affiliation: Division of Rheumatology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Harvard University, 330 Brookline Avenue, CLS937 Boston, MA 02215, USA.
authors.forename: George C
authors.initials: GC
authors.lastname: Tsokos
mesh_terms: D000818:Animals; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D051379:Mice; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology