title: [MULTIMODAL APPROACH IN THE TREATMENT OF PATIENTS WITH MALIGNANT PLEURAL LESIONS].
abstract: The study includes data on 54 patients with pleural malignant lesions (39 with metastatic pleural malignant tumors and 15 with pleural malignant mesothelioma) received treatment using a multimodal approach: maximum cytoreduction, intraoperative photodynamic therapy and hyperthermic chemoperfusion of pleural cavity. A control group of patients with malignant pleural mesothelioma consisted of 21 patients who had undergone only conservative treatment. It was found out that the use two-thoracotomy surgical approach had advantages over standard thoracotomy across IV intercostal space. The use of multimodal treatment was accompanied by relatively low (1.85%) postoperative mortality on the background of a relatively high number (79.6%) of postoperative complications, easily cured in the early postoperative period. The use of multimodal therapy in treatment for metastatic pleural malignant lesions was accompanied by a median of disease-free survival of 11 months and a median of overall survival of 23 months. The proposed multimodal treatment compared with conservative methods of therapy improved disease-free (12 months vs. 7.5 months) and overall (18.8 months vs. 10.2 months) survival. Thus the use of a multimodal approach in treatment for pleural malignant lesions is relatively safe but requires further study.
authors.forename: E V
authors.initials: EV
authors.lastname: Levchenko
authors.forename: O Yu
authors.initials: OY
authors.lastname: Mamontov
authors.forename: K Yu
authors.initials: KY
authors.lastname: Senchik
authors.forename: A S
authors.initials: AS
authors.lastname: Barchuk
authors.forename: M L
authors.initials: ML
authors.lastname: Gelfond
mesh_terms: D000328:Adult; D000368:Aged; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods; D065426:Cytoreduction Surgical Procedures; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D008654:Mesothelioma / Q000628:therapy; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D064847:Multimodal Imaging; D010778:Photochemotherapy; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D013908:Thoracotomy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome