title: Are campylobacters now capable of carbo-loading?
abstract: Campylobacters are a leading cause of gastrointestinal morbidity worldwide and the majority of human infections are triggered by eating foods contaminated with Campylobacter jejuni or Campylobacter coli. Campylobacters are equally notorious for their ability to mimic human glycoconjugate structures and for their capacity to synthesize both N- and O-linked glycoproteins. These species were once considered to be asaccharolytic, but it was recently shown that several strains possess a pathway for fucose uptake and metabolism, providing those isolates with a competitive advantage in vivo. Vorwerk et al. have now demonstrated through isotopologue profiling that certain strains of C. coli and C. jejuni are capable of glucose catabolism through the Entner-Doudoroff and pentose phosphate pathways. However, unlike the fate of fucose that has only been shown to be used for nutrition, glucose can be metabolized or incorporated into select amino acids and glycoconjugates. This discovery now provides researchers with the opportunity to introduce metabolically labeled sugars into campylobacters to study glycoconjugate biosynthesis within the cell. In addition, Vorwerk et al. add to the metabolic arsenal of campylobacters further highlighting the nutritional diversity among strains, even within the same species.
authors.affiliation: Alberta Glycomics Centre and Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2E9, Canada.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Szymanski
mesh_terms: D002167:Campylobacter; D002169:Campylobacter Infections; D017000:Campylobacter coli; D016123:Campylobacter jejuni / Q000378:metabolism; D002606:Charcoal; D006801:Humans
chemical_list: D002606:Charcoal