title: Individualized Prophylaxis in Patients with Esophageal Replacement Because of Cancer.
abstract: BACKGROUND
  Presented are the findings from an analysis of respiratory inflammatory complications in patients undergoing esophageal replacement because of cancer. Respiratory complications are manifested most frequently within five post-operative days, thus, they are likely to be caused by potentially pathogenic micro-organisms originating from the primary or secondary microflora.
  
  
  METHODS
  Sputum samples were collected 1-2 wks pre-operatively. In cases of positive microbiologic finding of some potential pathogens, individualized antibiotic prophylaxis was designed.
  
  
  RESULTS
  Patients with individualized prophylaxis had fewer respiratory complications (10%) than patients with general antibiotic prophylaxis (41%).
  
  
  CONCLUSIONS
  The approach to pre-operative sputum tests should be changed. If culture results are positive for bacteria with high resistance to antimicrobial agents or yeasts, the so-called individualized prophylaxis based on these particular results should be used.
authors.affiliation: 1 Surgical Intensive Care Unit, University Hospital Olomouc , Olomouc, Czech Republic .
authors.forename: Martina
authors.initials: M
authors.lastname: Horáková
authors.affiliation: 1 Surgical Intensive Care Unit, University Hospital Olomouc , Olomouc, Czech Republic .
authors.forename: Lucie
authors.initials: L
authors.lastname: Ĺubušká
authors.affiliation: 2 Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc , Olomouc, Czech Republic .
authors.forename: Milan
authors.initials: M
authors.lastname: Kolář
authors.affiliation: 2 Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc , Olomouc, Czech Republic .
authors.forename: Kristýna
authors.initials: K
authors.lastname: Hricová
authors.affiliation: 3 Department of Surgery I, University Hospital Olomouc , Olomouc, Czech Republic .
authors.forename: Radek
authors.initials: R
authors.lastname: Vrba
authors.affiliation: 3 Department of Surgery I, University Hospital Olomouc , Olomouc, Czech Republic .
authors.forename: Čestmír
authors.initials: Č
authors.lastname: Neoral
authors.affiliation: 4 Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc , Olomouc, Czech Republic .
authors.forename: Jana
authors.initials: J
authors.lastname: Zapletalová
mesh_terms: D019072:Antibiotic Prophylaxis / Q000379:methods*; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D004938:Esophageal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D057285:Precision Medicine / Q000379:methods*; D011300:Preoperative Care / Q000379:methods*; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D013183:Sputum / Q000382:microbiology; D016896:Treatment Outcome