title: Coexpression of cyclin D1 and alpha-internexin in oligodendroglial tumors.
abstract: Oligodendroglial tumors with neuronal differentiation cases have been reported in recent studies. Oligodendrocyte precursor cells (OPCs) give rise to both oligodendrocytes and neurons; however, little is known about the association between OPCs and oligodendroglial tumors with neuronal differentiation. Previously, we observed the coexpression of cyclin D1, one of the OPC markers, and alpha-internexin (INA) in oligodendroglial tumor cells. INA is a neuronal marker, and has been indicated as an immunohistochemical surrogate of chromosome 1p/19q co-deletion in oligodendroglial tumors. In this study, we investigated the expression status in 83 gliomas immunohistochemically, and found that cyclin D1-positive cells were commonly detected in gliomas. There was no correlation between the cyclin D1 and Ki-67 labeling indices, suggesting an unrecognized role of cyclin D1 other than a cell cycle regulator in gliomas. Cyclin D1/INA double-positive cells were consistently observed in oligodendroglial tumors regardless of histological grade. In 2 cases of oligodendroglioma with neuronal differentiation, the tumor cells of neuronal morphology showed higher expression of INA, suggesting INA expression may be associated with a bona fide neuronal phenotype. The prevalence of cyclin D1/INA double-positive cells is a distinct feature of oligodendroglial tumors. This new characteristic finding may have practical utility in glioma classification.
authors.affiliation: Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. nozomim@gunma-u.ac.jp.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Matsumura
authors.affiliation: Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
authors.forename: Sumihito
authors.initials: S
authors.lastname: Nobusawa
authors.affiliation: Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Ikota
authors.affiliation: Department of Pathology, Gunma University Hospital, Maebashi, Gunma, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Hirato
authors.affiliation: Department of Diagnostic Pathology, Hyogo Cancer Center, Akashi, Hyogo, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Hirose
authors.affiliation: Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yokoo
authors.affiliation: Department of Pathology, Hidaka Hospital, Takasaki, Gunma, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakazato
mesh_terms: D001932:Brain Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D019938:Cyclin D1 / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D015870:Gene Expression / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D009837:Oligodendroglioma / Q000145:classification / Q000235:genetics* / Q000473:pathology
chemical_list: C530104:CCND1 protein, human; D007381:Intermediate Filament Proteins; C046643:alpha-internexin; D019938:Cyclin D1
keywords: Alpha-internexin; Cyclin D1; Immunohistochemistry; Oligodendrocyte precursor cells; Oligodendroglioma