title: [Intratympanic therapy in the management of tinnitus].
abstract: Tinnitus is a common symptom which often becomes disabling, affecting the emotional and psychosocial dimensions of life. Nowadays, therapies for tinnitus vary greatly, none of which could give a satisfactory therapeutic effect however. Intratympanic therapy allows the generation of high concentration of drugs within the inner ear without systemic side effects. This review aims to introduce the commonly used medications and approaches for intratympanic management of tinnitus. Although different medications have been tested for their effects on tinnitus by intratympanic application, no breakthrough has been achieved so far. Consequently, the clinical use of specific medications for tinnitus has remained limited. A more widespread adoption of intratympanic management requires the development of specific medications for tinnitus, as well as proof of their safety and efficacy.
authors.forename: Shumin
authors.initials: S
authors.lastname: Xie
authors.forename: Jihao
authors.initials: J
authors.lastname: Ren
mesh_terms: D007758:Ear, Inner; D006801:Humans; D014012:Tinnitus / Q000188:drug therapy*; D014432:Tympanic Membrane