title: Congenital Chikungunya Virus Infection in Sincelejo, Colombia: A Case Series.
abstract: Congenital chikungunya virus (CHIK) infection has been infrequently reported, even more so during the current 2013-15 outbreak in Latin America. In this study, the consequences of CHIK on pregnancy outcomes and particularly consequences in infants born to infected women were assessed in a case series from a single private institution in the north of Colombia. During September 2014 to February 2015, seven pregnant women with serological and reverse transcription-polymerase chain reaction-positive test for CHIK delivered eight infants with CHIK. These newborns required admission to pediatric intensive care, and related support, owing to severe clinical manifestations, which included respiratory distress, sepsis, necrotizing enterocolitis, meningoencephalitis, myocarditis, edema, bullous dermatitis and pericarditis. There were three deaths (case fatality rate of 37.5%). Pregnant women and newborns with CHIK long term should be followed up, given the implications of chronic sequelae (e.g. chronic inflammatory rheumatism in women) as well as recently described neurocognitive impairment in infants.
authors.affiliation: Grupo de Investigación Enfermedades Infecciosas, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia Grupo de Investigación Enfermedades Infecciosas, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia Doctoral Program of Tropical Medicine, Universidad de Cartagena, Cartagena, Bolívar, Colombia Doctoral Program of Tropical Medicine, Universidad del Atlántico, Barranquilla, Atlántico, Colombia.
authors.forename: Wilmer
authors.initials: W
authors.lastname: Villamil-Gómez
authors.affiliation: Grupo de Investigación Enfermedades Infecciosas, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia Doctoral Program of Tropical Medicine, Universidad de Cartagena, Cartagena, Bolívar, Colombia.
authors.forename: Luz
authors.initials: L
authors.lastname: Alba-Silvera
authors.affiliation: Committee on Zoonoses and Haemorrhagic Fevers, Asociación Colombiana de Infectología (ACIN), Bogotá, DC, Colombia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Menco-Ramos
authors.affiliation: Neonatal Intensive Care Unit, Clínica Santa María, Sincelejo, Sucre, Colombia.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Gonzalez-Vergara
authors.affiliation: Committee on Zoonoses and Haemorrhagic Fevers, Asociación Colombiana de Infectología (ACIN), Bogotá, DC, Colombia.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Molinares-Palacios
authors.affiliation: Committee on Zoonoses and Haemorrhagic Fevers, Asociación Colombiana de Infectología (ACIN), Bogotá, DC, Colombia.
authors.forename: María
authors.initials: M
authors.lastname: Barrios-Corrales
authors.affiliation: Doctoral Program of Tropical Medicine, Universidad del Atlántico, Barranquilla, Atlántico, Colombia Department of Pediatrics, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia arodriguezm@utp.edu.co.
authors.forename: Alfonso J
authors.initials: AJ
authors.lastname: Rodríguez-Morales
mesh_terms: D000328:Adult; D065632:Chikungunya Fever / Q000175:diagnosis*; D002646:Chikungunya virus; D003105:Colombia / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
keywords: Chikungunya; Colombia; arbovirus; congenital; epidemiology