title: Blood cells: an historical account of the roles of purinergic signalling.
abstract: The involvement of purinergic signalling in the physiology of erythrocytes, platelets and leukocytes was recognised early. The release of ATP and the expression of purinoceptors and ectonucleotidases on erythrocytes in health and disease are reviewed. The release of ATP and ADP from platelets and the expression and roles of P1, P2Y(1), P2Y(12) and P2X1 receptors on platelets are described. P2Y(1) and P2X(1) receptors mediate changes in platelet shape, while P2Y(12) receptors mediate platelet aggregation. The changes in the role of purinergic signalling in a variety of disease conditions are considered. The successful use of P2Y(12) receptor antagonists, such as clopidogrel and ticagrelor, for the treatment of thrombosis, myocardial infarction and stroke is discussed.
authors.affiliation: Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK. g.burnstock@ucl.ac.uk.|Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne, Australia. g.burnstock@ucl.ac.uk.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Burnstock
mesh_terms: D000244:Adenosine Diphosphate / Q000502:physiology; D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D001773:Blood Cells / Q000502:physiology*; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology; D006801:Humans; D010974:Platelet Aggregation / Q000502:physiology; D011983:Receptors, Purinergic / Q000097:blood* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011983:Receptors, Purinergic; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate
keywords: ADP; Adenosine; Clopidogrel; Erythrocytes; P2X1; P2Y1; P2Y12; Platelets; Purinoceptor; Thrombosis