title: Relationship between periodontal parameters and plasma cytokine profiles in pregnant woman with preterm birth or low birth weight.
abstract: OBJECTIVE
  The aim was to determine whether clinical periodontal parameters are associated with plasma anti- and/or pro-inflammatory cytokines in pregnant woman with preterm birth (PB) or low birth weight (LBW) neonates.
  
  
  METHODS
  An observational case-control study was performed in 131 puerperal women: mothers of PB/LBW neonates (cases, n = 67) and mothers of full-term normal-weight neonates (controls, n = 64). Sociodemographic and periodontal data was gathered from all participants, and interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17, IL-23, and tumor necrosis factor alpha (TNF-α) were determined in plasma.
  
  
  RESULTS
  In multiple linear regression models, clinical attachment loss was associated with TNF-α (0.28 ± 0.14; 95% confidence interval (CI) [0.006, 0.553]) and IL-1β (0.43 ± 0.21; 95%CI [0.018, 0.842]), independent of group membership. IL-1β (-1.67 ± 0.27, 95%CI [-2.199, -1.141]), IL-6 (-0.86 ± 0.27; 95%CI [-1.389, -0.331]), and IL-8 (-3.84 ± 0.50, 95%CI [-4.820, -2.860]) were lower, and IL-10 (0.86 ± 0.26; 95%CI [0.350, 1.370]) was higher in cases versus controls after adjusting for potential confounders.
  
  
  CONCLUSIONS
  Clinical attachment loss was associated with plasma TNF-α and IL-1β levels. No plasma cytokine profiles suggestive of systemic inflammatory response were observed in the pregnant women with PB/LBW neonates.
  
  
  CONCLUSIONS
  Clinical attachment loss, as the main periodontal measure, is associated with TNF-α and IL-1β plasma levels in pregnant women. No relationship was found between PB/LBW and the markers of systemic inflammatory response assessed in this study.
authors.affiliation: Periodontology Department, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain. fmesa@ugr.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Mesa
authors.affiliation: Periodontology Department, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Pozo
authors.affiliation: Pathology Department, School of Medicine, University of Granada, Avda. De Madrid s/n, 18012, Granada, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: O'Valle
authors.affiliation: Department of Obstetrics and Gynecology, Virgen de las Nieves University Hospital, Avda. Fuerzas Armadas 2, 18014, Granada, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Puertas
authors.affiliation: Periodontology Department, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Magan-Fernandez
authors.affiliation: Department of Preventive Dentistry and Epidemiology, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Rosel
authors.affiliation: Department of Preventive Dentistry and Epidemiology, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Bravo
mesh_terms: D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007249:Inflammation; D016753:Interleukin-10; D010512:Periodontal Index; D011247:Pregnancy; D047928:Premature Birth; D014409:Tumor Necrosis Factor-alpha
chemical_list: D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
keywords: Chronic periodontitis; Cytokines; Enzyme-linked immunosorbent assay; Premature birth