title: Arterial stiffness as a predictor of recovery of left ventricular systolic function after acute myocardial infarction treated with primary percutaneous coronary intervention.
abstract: Left ventricular ejection fraction (LVEF) and pulse wave velocity (PWV) are acknowledged as independent risk factors in different high-risk populations. We investigated the effects of arterial stiffness on LV function at 3 and 6 months after acute myocardial infarction. Changes in LVEF were evaluated in 136 consecutive patients who were diagnosed with ST-segment elevation coronary syndrome and treated with primary percutaneous coronary intervention. Doppler guided by 2D ultrasound was used to measure carotid-femoral PWV. According to tertiles of arterial stiffness, a significant correlation between higher PWV and worse recovery in LVEF was found (3 months EF change: 9.9 ± 5.0% vs 5.9 ± 3.4 vs 3.8 ± 1.6; p < 0.001 and 6 months EF change: 18.5 ± 7.0% vs 11.5 ± 5.2 vs 7.3 ± 3.0; p = 0.002). In the multivariate analysis PWV showed the ability to predict the outcome in terms of EF recovery at 3 and 6 months also after any correction for age and other variables (β = -0.566, p < 0.001). Arterial stiffening may result in a less effective recovery of LV function after acute myocardial infarction.
authors.affiliation: Department of Clinical and Experimental Medicine, Policlinic University of Messina, Via Consolare Valeria n.1, 98125, Messina, Italy. eimbalzano@unime.it.
authors.forename: Egidio
authors.initials: E
authors.lastname: Imbalzano
authors.affiliation: UTIC and Cardiology, Hospital "Pugliese-Ciaccio", Catanzaro, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Vatrano
authors.affiliation: Department of Clinical and Experimental Medicine, Policlinic University of Messina, Via Consolare Valeria n.1, 98125, Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mandraffino
authors.affiliation: Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Ghiadoni
authors.affiliation: Department of Clinical and Experimental Medicine, Policlinic University of Messina, Via Consolare Valeria n.1, 98125, Messina, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gangemi
authors.affiliation: Institute of Clinical Physiology, National Research Council, Pisa, Italy.
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Bruno
authors.affiliation: UTIC and Cardiology, Hospital "Pugliese-Ciaccio", Catanzaro, Italy.
authors.forename: Vincenzo Antonio
authors.initials: VA
authors.lastname: Ciconte
authors.affiliation: Railway Health Care Institute, Belgrade, Serbia.
authors.forename: Nevena
authors.initials: N
authors.lastname: Paunovic
authors.affiliation: Department of Clinical and Experimental Medicine, Policlinic University of Messina, Via Consolare Valeria n.1, 98125, Messina, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Costantino
authors.affiliation: Department of Biomedical Sciences and of Morphologic and Functional Images, University of Messina, Messina, Italy.
authors.forename: Enrico Maria
authors.initials: EM
authors.lastname: Mormina
authors.affiliation: UTIC and Cardiology, Hospital "Pugliese-Ciaccio", Catanzaro, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ceravolo
authors.affiliation: Department of Clinical and Experimental Medicine, Policlinic University of Messina, Via Consolare Valeria n.1, 98125, Messina, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Saitta
authors.affiliation: Department of Clinical and Experimental Medicine, Policlinic University of Messina, Via Consolare Valeria n.1, 98125, Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Dattilo
mesh_terms: D000368:Aged; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D020127:Recovery of Function; D012307:Risk Factors; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D016896:Treatment Outcome; D018617:Ultrasonography, Doppler, Pulsed; D059289:Vascular Stiffness; D016277:Ventricular Function, Left
keywords: Arterial stiffness; Left ventricular systolic function; Myocardial infarction; Pulse wave velocity; STEMI