title: Children with cerebral palsy have uncharacteristic somatosensory cortical oscillations after stimulation of the hand mechanoreceptors.
abstract: Numerous clinical investigations have reported that children with cerebral palsy (CP) have tactile discrimination deficits that likely limit their ability to plan and manipulate objects. Despite this clinical awareness, we still have a substantial knowledge gap in our understanding of the neurological basis for these tactile discrimination deficits. Previously, we have shown that children with CP have aberrant theta-alpha (4-14 Hz) oscillations in the somatosensory cortices following tactile stimulation of the foot. In this investigation, we evaluated if these aberrant theta-alpha oscillations also extend to the hand. Magnetoencephalography was used to evaluate event-related changes in the theta-alpha and beta (18-34 Hz) somatosensory cortical oscillations in groups of children with CP and typically developing (TD) children following tactile stimulation of their hands. Our results showed that the somatosensory theta-alpha oscillations were relatively intact in children with CP, which is in contrast to our previous results for foot tactile stimulations. We suspect that these inter-study differences may be related to the higher probability that the neural tracts serving the lower extremities are damaged in children with CP, compared to those serving the upper extremities. This inference is plausible since the participating children with CP had Manual Ability Classification System (MACS) levels between I and II. In contrast to the theta-alpha results, children with CP did exhibit a sharp increase in beta activity during the same time period, which was not observed in TD children. This suggests that children with CP still have deficits in the computational aspect of somatosensory processing.
authors.affiliation: Department of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, United States; Center for Magnetoencephalography (MEG), University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: mkurz@unmc.edu.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kurz
authors.affiliation: Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Center for Magnetoencephalography (MEG), University of Nebraska Medical Center, Omaha, NE, United States.
authors.forename: K M
authors.initials: KM
authors.lastname: Becker
authors.affiliation: Center for Magnetoencephalography (MEG), University of Nebraska Medical Center, Omaha, NE, United States; Department of Psychology, University of Nebraska - Omaha, Omaha, NE, United States.
authors.forename: E
authors.initials: E
authors.lastname: Heinrichs-Graham
authors.affiliation: Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Department of Neurology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Center for Magnetoencephalography (MEG), University of Nebraska Medical Center, Omaha, NE, United States.
authors.forename: T W
authors.initials: TW
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002547:Cerebral Palsy / Q000473:pathology*; D002648:Child; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006225:Hand / Q000294:innervation*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D013003:Somatosensory Cortex / Q000503:physiopathology*; D013997:Time Factors
keywords: alpha; beta; magnetoencephalography; sensory; tactile; theta