title: Developing stem cell therapies for juvenile and adult-onset Huntington's disease.
abstract: Stem cell therapies have been explored as a new avenue for the treatment of neurologic disease and damage within the CNS in part due to their native ability to mimic repair mechanisms in the brain. Mesenchymal stem cells have been of particular clinical interest due to their ability to release beneficial neurotrophic factors and their ability to foster a neuroprotective microenviroment. While early stem cell transplantation therapies have been fraught with technical and political concerns as well as limited clinical benefits, mesenchymal stem cell therapies have been shown to be clinically beneficial and derivable from nonembryonic, adult sources. The focus of this review will be on emerging and extant stem cell therapies for juvenile and adult-onset Huntington's disease.
authors.affiliation: Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
authors.forename: Kyle D
authors.initials: KD
authors.lastname: Fink
authors.affiliation: Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
authors.forename: Peter
authors.initials: P
authors.lastname: Deng
authors.affiliation: Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
authors.forename: Audrey
authors.initials: A
authors.lastname: Torrest
authors.affiliation: Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
authors.forename: Heather
authors.initials: H
authors.lastname: Stewart
authors.affiliation: Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
authors.forename: Kari
authors.initials: K
authors.lastname: Pollock
authors.affiliation: Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
authors.forename: William
authors.initials: W
authors.lastname: Gruenloh
authors.affiliation: Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
authors.forename: Geralyn
authors.initials: G
authors.lastname: Annett
authors.affiliation: GenomeCenter, Biochemistry & Molecular Medicine, University of California, 451 Health Sciences Dr. Davis, CA 95616 USA.
authors.forename: Teresa
authors.initials: T
authors.lastname: Tempkin
authors.affiliation: Department of Neurology, University of California Davis Health Systems, 4860 Y Street Sacramento, CA, 95817 USA.
authors.forename: Vicki
authors.initials: V
authors.lastname: Wheelock
authors.affiliation: Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
authors.forename: Jan A
authors.initials: JA
authors.lastname: Nolta
mesh_terms: D000328:Adult; D000818:Animals; D030801:Animals, Genetically Modified; D002454:Cell Differentiation; D017690:Cell Transplantation / Q000379:methods; D002490:Central Nervous System / Q000473:pathology; D002648:Child; D002986:Clinical Trials as Topic; D018450:Disease Progression; D053595:Embryonic Stem Cells / Q000166:cytology; D006801:Humans; D006816:Huntington Disease / Q000628:therapy*; D007107:Immune System; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D009414:Nerve Growth Factors / Q000737:chemistry; D009474:Neurons / Q000378:metabolism; D000066829:Neuroprotection; D033581:Stem Cell Transplantation
chemical_list: D009414:Nerve Growth Factors
keywords: Huntington's disease; regenerative medicine; stem cell; transplantation