title: Evaluation of Anthropometric and Metabolic Parameters in Obstructive Sleep Apnea.
abstract: OBJECTIVE
  Sleep disorders have recently become a significant public health problem worldwide and have deleterious health consequences. Obstructive sleep apnea (OSA) is the most common type of sleep-related breathing disorders. We aimed to evaluate anthropometric measurements, glucose metabolism, and cortisol levels in patients with obstructive sleep apnea (OSA).
  
  
  METHODS
  A total of 50 patients with a body mass index ≥30 and major OSA symptoms were included in this study. Anthropometric measurements of the patients were recorded and blood samples were drawn for laboratory analysis. A 24-hour urine sample was also collected from each subject for measurement of 24-hour cortisol excretion. Patients were divided equally into 2 groups according to polysomnography results: control group with an apnea-hypopnea index (AHI) <5 (n = 25) and OSA group with an AHI ≥5 (n = 25).
  
  
  RESULTS
  Neck and waist circumference, fasting plasma glucose, HbA1c, late-night serum cortisol, morning serum cortisol after 1 mg dexamethasone suppression test, and 24-hour urinary cortisol levels were significantly higher in OSA patients compared to control subjects. Newly diagnosed DM was more frequent in patients with OSA than control subjects (32% versus 8%, p = 0.034). There was a significant positive correlation between AHI and neck circumference, glucose, and late-night serum cortisol.
  
  
  CONCLUSIONS
  Our study indicates that increased waist and neck circumferences constitute a risk for OSA regardless of obesity status. In addition, OSA has adverse effects on endocrine function and glucose metabolism.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Yildirim
authors.affiliation: Department of Pulmonology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Süreyya
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Güven
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Kılınç
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Ali Veysel
authors.initials: AV
authors.lastname: Kara
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Zülfükar
authors.initials: Z
authors.lastname: Yilmaz
authors.affiliation: Department of Pulmonology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Kırbaş
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Alpaslan Kemal
authors.initials: AK
authors.lastname: Tuzcu
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Yılmaz Aydın
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001837:Body Weights and Measures; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006854:Hydrocortisone; C517652:hemoglobin A1c protein, human