title: A Serological Epidemiological Survey of Antibodies against 4 HPV Subtypes in Uygur Women in Xinjiang.
abstract: This study evaluated the distribution of antibodies against 4 human papillomavirus (HPV) subtypes and their related factors among Uygur women in Xinjiang. A cross-sectional study was conducted from March 2006 to May 2007 involving 883 Uygur women aged 17-54 years living in Yutian County. Demographic indicators, disease history, sexual behavior history, and other parameters were recorded at the interview using a questionnaire. A fluorescence detection method was used to quantify anti-HPV6, -11, -16, and -18 antibodies in venous blood serum. The rate of positive detection of any anti-HPV antibody (anti-HPV6, -11, -16, and -18) in the study population was 13.4%, and the individual positivity rates were 9.5%, 2.6%, 4.3%, and 0.7%, respectively. Peak rates of positivity for the anti-HPV16 antibody were found in women who were 36-40 and 46-50 years old. Seroprevalence of HPV16, which is high-risk for cervical cancer, was associated with the numbers of sexual partners. The rate of infection with high-risk HPV was low among Uygur women from rural areas, although there is a high incidence of cervical cancer in this group. Loyalty to one sexual partner decreased the risk of high-risk HPV infection. This study may provide useful reference data for the prevention and treatment of HPV and cervical cancer and for the application of HPV vaccines.
authors.affiliation: Department of Gynecology, Cancer Institute/hospital, Xinjiang people's Hospital.
authors.forename: Sulaiya
authors.initials: S
authors.lastname: Husaiyin
authors.forename: Lili
authors.initials: L
authors.lastname: Han
authors.forename: Huduyum
authors.initials: H
authors.lastname: Mamat
authors.forename: Kundus
authors.initials: K
authors.lastname: Husaiyin
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Mayinuer
authors.initials: M
authors.lastname: Niyazi
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002681:China; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006306:Health Surveys; D052140:Human papillomavirus 11 / Q000276:immunology* / Q000302:isolation & purification; D052162:Human papillomavirus 16 / Q000276:immunology* / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000276:immunology* / Q000302:isolation & purification; D052163:Human papillomavirus 6 / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000208:ethnology / Q000276:immunology / Q000821:virology; D012309:Risk-Taking; D012424:Rural Population; D016036:Seroepidemiologic Studies; D012725:Sexual Behavior / Q000208:ethnology / Q000523:psychology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000276:immunology / Q000821:virology
chemical_list: D000914:Antibodies, Viral