title: Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients.
abstract: The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p = 0.002; per-vessel: specificity 95 versus 75%, p = 0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40-70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.
authors.affiliation: Department of Imaging Methods, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Baxa
authors.affiliation: Department of Cardiology, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Hromádka
authors.affiliation: Department of Cardiology, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Šedivý
authors.affiliation: Department of Internal Medicine, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Štěpánková
authors.affiliation: Department of Surgery, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Moláček
authors.affiliation: Siemens Healthcare, CT Physics and Applications Development, Siemensstrasse 1, 91301 Forchheim, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schmidt
authors.affiliation: Siemens Healthcare, CT Physics and Applications Development, Siemensstrasse 1, 91301 Forchheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Flohr
authors.affiliation: Department of Imaging Methods, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Ferda
mesh_terms: D001794:Blood Pressure; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D011687:Purines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D014057:Tomography, X-Ray Computed
chemical_list: D011687:Purines; D011720:Pyrazoles; C430916:regadenoson