title: [Effect of Volatile Oil of Radix Angelicae Sinensis on experimental asthma in rats].
abstract: OBJECTIVE
  To study the effects of Volatile Oil of Radix Angelicae Sinensis (VOA) on experimental asthma in rat model based on abnormal immune functions of Treg cells.
  
  
  METHODS
  After grouping, the asthmatic rats were developed through injecting OVA and AI(OH)3 for sensitization and then administering OVA aerosol for challenge, and the respiratory functions, asthmatic behaviors, IL-10 levels in bronchoalveolar lavage fluid (BALF) (ELISA) and Foxp3 expression (immunohistochemistry) in lung of asthmatic rats were observed.
  
  
  RESULTS
  VOA at the doses of 40-160 mg/kg could improve the respiratory functions and the asthmatic behaviors, and upgrade IL-10 levels in BALF and Foxp3 expression in lung of asthmatic rats.
  
  
  CONCLUSIONS
  VOA has some effects of anti-asthma and one of the mechanisms is to improving the lower immune functions of Treg cells.
authors.forename: Zhi-wang
authors.initials: ZW
authors.lastname: Wang
authors.forename: Rong-ke
authors.initials: RK
authors.lastname: Li
authors.forename: Xing-yao
authors.initials: XY
authors.lastname: Lin
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ren
authors.forename: Xue-feng
authors.initials: XF
authors.lastname: Liu
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Cheng
authors.forename: Rui-qiong
authors.initials: RQ
authors.lastname: Wang
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004195:Disease Models, Animal; D051858:Forkhead Transcription Factors / Q000378:metabolism; D016753:Interleukin-10 / Q000737:chemistry; D008168:Lung / Q000378:metabolism; D009822:Oils, Volatile / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000166:cytology
chemical_list: D051858:Forkhead Transcription Factors; C500522:Foxp3 protein, rat; D009822:Oils, Volatile; D010938:Plant Oils; D016753:Interleukin-10