title: The effect of 48-hour fasting on taurine status in healthy adult dogs.
abstract: Low circulating taurine concentrations may be a risk factor for dilated cardiomyopathy (DCM) in dogs. Circulating taurine is typically measured in the clinic 4-5 h after feeding, largely because the impact of later sampling is not known. The objective of this study was to measure taurine in the blood during a 48-h fast in 12 healthy adult Labrador Retrievers to refine sampling methodology for determination of taurine status. Plasma and whole blood (WB) taurine concentrations did not fall to levels indicative of clinical deficiency throughout fasting; WB was the more reliable indicator of taurine status. This study shows that blood samples can be taken for assessment of taurine status any time up to 48 h after ingestion of a meal in healthy adult dogs.
authors.affiliation: WALTHAM Centre for Pet Nutrition, Mars Petcare, Leicestershire, UK.
authors.forename: K
authors.initials: K
authors.lastname: Gray
authors.affiliation: WALTHAM Centre for Pet Nutrition, Mars Petcare, Leicestershire, UK.
authors.forename: L G
authors.initials: LG
authors.lastname: Alexander
authors.affiliation: WALTHAM Centre for Pet Nutrition, Mars Petcare, Leicestershire, UK.
authors.forename: R
authors.initials: R
authors.lastname: Staunton
authors.affiliation: WALTHAM Centre for Pet Nutrition, Mars Petcare, Leicestershire, UK.
authors.forename: A
authors.initials: A
authors.lastname: Colyer
authors.affiliation: Royal Canin, Mars Petcare, Aimargues, France.
authors.forename: A
authors.initials: A
authors.lastname: Watson
authors.affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, California, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Fascetti
mesh_terms: D000818:Animals; D004285:Dogs / Q000097:blood* / Q000502:physiology; D005508:Food Deprivation / Q000502:physiology*; D013654:Taurine / Q000097:blood*; D013997:Time Factors
chemical_list: D013654:Taurine
keywords: dilated cardiomyopathy; fasting; labrador; methionine; sulphur amino acid