title: Management of cryptococcal meningitis in a district hospital in KwaZulu-Natal: a clinical audit.
abstract: BACKGROUND
  Despite the development of context-specific guidelines, cryptococcal meningitis (CCM) remains a leading cause of death amongst HIV-infected patients. Results from clinical audits in routine practice have shown critical gaps in clinicians' adherence to recommendations regarding the management of CCM.
  
  
  OBJECTIVE
  The aim of this study was to review the acute management of CCM at an urban district hospital in KwaZulu-Natal, South Africa with a view to making recommendations for improving care.
  
  
  METHODS
  An urban district hospital in KwaZulu-Natal, South Africa.
  
  
  METHODS
  A retrospective audit was performed on clinical records of all patients (age > 13 years) admitted to the hospital with a diagnosis of CCM between June 2011 and December 2012.
  
  
  RESULTS
  Measurement of cerebrospinal fluid opening pressure at initial lumbar puncture (LP) was done rarely and only 23.4% of patients had therapeutic LPs. The majority of patients (117/127; 92.1%) received amphotericin B, however, only 19 of the 117 patients (16.2%) completed the 14-day treatment target. Amphotericin B-toxicity monitoring and prevention was suboptimal; however, in-patient referral for HIV counselling and testing was excellent.
  
  
  CONCLUSIONS
  The quality of care of CCM based on selected process criteria showed gaps in routine care at the hospital despite the availability of context-specific guidelines. An action plan for improving care was developed based on stakeholders' feedback. A repeat audit should be conducted in the future in order to evaluate the impact of this plan and to ensure that improvements are sustained.
authors.affiliation: Department of Family Medicine, Pietermaritzburg Hospitals Complex and University of KwaZulu-Natal. ben_adeyemi@yahoo.com.
authors.forename: Benjamin O
authors.initials: BO
authors.lastname: Adeyemi
authors.forename: Andrew
authors.initials: A
authors.lastname: Ross
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D005437:Flucytosine / Q000627:therapeutic use; D006786:Hospitals, Urban; D006801:Humans; D008297:Male; D008485:Medical Audit; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000453:epidemiology; D012189:Retrospective Studies; D013019:South Africa / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine