title: Sudden Cardiac Death in a Young Man with Migraine-associated Arrhythmia.
abstract: A 31-year-old man with migraine-induced syncope and bradycardia with subsequent pacemaker implantation died unexpectedly. Clinically unsuspected cardiac anomalies were found at autopsy including myocardial bridging of the left anterior descending artery and shelf-like coronary artery ostia. Nortriptyline was identified by toxicologic analysis. A review of the autopsy findings, the historical information, and the effects of the possible arrhythmogenic circumstances is undertaken and the potential contributions to the death are discussed. Cardiac arrhythmias have been documented during migraines. Coronary artery bridging has been known to lead to ischemia and infarction, ventricular tachycardia, and sudden death; however, these are very rare sequelae. Congenital coronary artery anomalies have been linked to sudden cardiac death, but only rarely cause death in people younger than 31 years. Migraines and the autopsy findings described have been associated with cardiac arrhythmia and sudden death. Altogether, they led to the unexpected death of this young man.
authors.affiliation: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC-908, Charleston, SC, 29425.
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Monroe
authors.affiliation: Division of Cardiology, Medical University of South Carolina, 171 Ashley Avenue, MSC-908, Charleston, SC, 29425.
authors.forename: John T
authors.initials: JT
authors.lastname: Meehan
authors.affiliation: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC-908, Charleston, SC, 29425.
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Schandl
mesh_terms: D000328:Adult; D001919:Bradycardia / Q000209:etiology; D003330:Coronary Vessel Anomalies / Q000473:pathology; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000150:complications*; D010138:Pacemaker, Artificial; D013575:Syncope / Q000209:etiology; D017180:Tachycardia, Ventricular / Q000209:etiology*
keywords: arrhythmia; autopsy; coronary ostia; forensic pathology; forensic science; migraine; myocardial bridging; pacemaker; sudden death; young