title: The use of 18F-FDG PET ratios in the differential diagnosis of common malignant brain tumors.
abstract: OBJECTIVE
  This study examined the use of positron emission tomography (PET) ratios to improve the diagnostic ability of 18F-FDG PET/computed tomography (CT) in the differentiation of enhancing brain metastases, central nervous system lymphomas, and gliomas.
  
  
  METHODS
  Seventy-six patients with malignant brain tumors and available magnetic resonance imaging and PET/CT examinations were included.
  
  
  RESULTS
  Among standardized uptake value (SUV)-related parameters tested, tumor maximum SUV to ipsilateral cortex maximum SUV ratio (Tmax:WMimax) and maximum SUV (SUVmax) proved to be the two most valuable parameters for differential diagnosis.
  
  
  CONCLUSIONS
  In addition to SUVmax, Tmax:WMimax also seems to provide helpful information for the differential diagnosis of lymphomas from other malignant brain tumors.
authors.affiliation: Department of Radiology, University of Minnesota Medical Center, Fairview, Minneapolis, MN, USA.
authors.forename: Kaan
authors.initials: K
authors.lastname: Meric
authors.affiliation: Department of Nuclear Medicine, Weill Cornell Medical Center/NewYork-Presbyterian Hospital, New York, NY, USA.
authors.forename: Ronan P
authors.initials: RP
authors.lastname: Killeen
authors.affiliation: Department of Nuclear Medicine, Weill Cornell Medical Center/NewYork-Presbyterian Hospital, New York, NY, USA.
authors.forename: Alain S
authors.initials: AS
authors.lastname: Abi-Ghanem
authors.affiliation: Department of Nuclear Medicine, Weill Cornell Medical Center/NewYork-Presbyterian Hospital, New York, NY, USA.
authors.forename: Fatima
authors.initials: F
authors.lastname: Soliman
authors.affiliation: Department of Radiology, Marmara University Medical School, Istanbul, Turkey.
authors.forename: Fuad
authors.initials: F
authors.lastname: Novruzov
authors.affiliation: Department of Economics, University of New Haven, West Haven, Boston, USA.
authors.forename: Esin
authors.initials: E
authors.lastname: Cakan
authors.affiliation: Department of Radiology, University of Minnesota Medical Center, Fairview, Minneapolis, MN, USA. Electronic address: cayci001@umn.edu.
authors.forename: Zuzan
authors.initials: Z
authors.lastname: Cayci
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG positron emission tomography; Brain metastasis; Central nervous system lymphoma; Differential diagnosis; Glioma