title: Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart.
abstract: We have advocated an axial flow blood pump called "valvo pump" that is implanted at the aortic valve position, and we have developed axial flow blood pumps to realize the concept of the valvo pump. The latest model of the axial flow blood pump mainly consists of a stator, a directly driven impeller, and a hydrodynamic bearing. The axial flow blood pump has a diameter of 33 mm and length of 74 mm, and the length of anatomical occupation is 33 mm. The axial flow blood pump is anastomosed to the aorta with polytetrafluoroethylene (PTFE) cuffs worn on the inflow and outflow ports. Dp-Q curves of the axial flow blood pump are flatter than those of ordinary axial flow pumps, and pump outflow of 5 L/min was obtained against a pressure difference of 50 mm Hg at a rotational speed of 9000 rpm in vitro. The axial flow blood pump was installed in a goat by anastomosing with the thoracic descending aorta using PTFE cuffs, and it was rotated at a rotational speed of 8000 rpm. Unlike in case of the ventricular assistance in parallel with the natural heart, pulsatilities of aortic pressure and aortic flow were preserved even when the pump was on, and mean aortic flow was increased by 1.5 L/min with increase in mean aortic pressure of 30 mm Hg. In conclusion, circulatory assistance in series with the natural heart using the axial flow blood pump was able to improve hemodynamic pulsatility, and it would contribute to improvement of end-organ circulation. .
authors.affiliation: Graduate School of Science and Engineering, Tokai University, Sapporo, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Okamoto
authors.affiliation: Faculty of Systems Science and Technology, Akita Prefectural University, Yuri-Honjo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yano
authors.affiliation: Institute of Development Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shiraishi
authors.affiliation: Institute of Development Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Miura
authors.affiliation: Institute of Development Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yambe
authors.affiliation: Hokkaido University, Sapporo, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000503:physiopathology / Q000601:surgery*; D001021:Aortic Valve / Q000503:physiopathology; D001783:Blood Flow Velocity; D006041:Goats; D006353:Heart-Assist Devices; D006439:Hemodynamics; D008422:Materials Testing; D008904:Miniaturization; D023421:Models, Animal; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000295:instrumentation*; D012039:Regional Blood Flow; D013997:Time Factors; D016277:Ventricular Function, Left
keywords: Artificial heart; Axial flow pump; Pulsatility; Ventricular assist device