title: A luminescent ruthenium(II) complex for light-triggered drug release and live cell imaging.
abstract: We report a novel ruthenium(II) complex for selective release of the imidazole-based drug econazole. While the complex is highly stable and luminescent in the dark, irradiation with green light induces release of one of the econazole ligands, which is accompanied by a turn-off luminescence response and up to a 34-fold increase in cytotoxicity towards tumour cells.
authors.affiliation: School of Chemistry, University of Sydney, Sydney, Australia. anna.renfrew@sydney.edu.au.
authors.forename: Nora
authors.initials: N
authors.lastname: Karaoun
authors.forename: Anna K
authors.initials: AK
authors.lastname: Renfrew
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D058948:Cell Tracking / Q000379:methods*; D056831:Coordination Complexes / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004464:Econazole / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D008027:Light; D049408:Luminescent Agents / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D010778:Photochemotherapy; D012428:Ruthenium / Q000737:chemistry*; D013054:Spectrophotometry, Atomic
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D049408:Luminescent Agents; D004464:Econazole; D012428:Ruthenium