title: Additive effect of BPA and Gd-DTPA for application in accelerator-based neutron source.
abstract: Because of its fast metabolism gadolinium as a commercial drug was not considered to be suitable for neutron capture therapy. We studied additive effect of gadolinium and boron co-administration using colony forming assay. As a result, the survival of tumor cells with additional 5 ppm of Gd-DTPA decreased to 1/10 compared to the cells with boron only. Using gadolinium to increase the effect of BNCT instead of additional X-ray irradiation might be beneficial, as such combination complies with the short-time irradiation regimen at the accelerator-based neutron source.
authors.affiliation: Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Electronic address: yoshida.fumiyo.ff@u.tsukuba.ac.jp.
authors.forename: F
authors.initials: F
authors.lastname: Yoshida
authors.affiliation: Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakai
authors.affiliation: Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Zaboronok
authors.affiliation: Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Matsumura
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000008:administration & dosage*; D016754:Boron Neutron Capture Therapy; D002460:Cell Line; D045744:Cell Line, Tumor; D006224:Cricetinae; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D010649:Phenylalanine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001896:Boron Compounds; D010649:Phenylalanine; D019786:Gadolinium DTPA; C033685:4-boronophenylalanine
keywords: Accelerator-based neutron source; BPA; Gd-DTPA