title: Prevalence of cavum vergae in psychosis and mood spectrum disorders.
abstract: BACKGROUND
  Midline brain abnormalities might increase susceptibility to both first-episode and chronic mental disorder. Evidence of cavum vergae (CV) abnormality in mental disorders is scarce.
  
  
  METHODS
  The presence of CV was assessed by a researcher blind to clinical information in a cross-disorder sample of 639 patients with mood and psychotic disorders and in 223 healthy controls. Homogeneous magnetic resonance imaging methods of acquisition and assessment were applied.
  
  
  RESULTS
  Seven out of 639 patients with mood or psychotic disorders were detected with CV which corresponds to a prevalence of 1.1%. There were no concurrent cases of CV in the healthy control group. Identified cases which are briefly described were diagnosed from bipolar I disorder (n=2), delusional disorder (n=1), brief psychotic disorder (n=1) and schizoaffective disorder (n=3). Patients with CV had descriptively lower current IQ, executive functioning and memory scores in relation to patients without CV but this was not statistically significant.
  
  
  CONCLUSIONS
  Effects of medication and lack of statistical power of the CV patient group.
  
  
  CONCLUSIONS
  Midline brain abnormalities, such as CV, might represent an unspecific risk factor for the development of severe mental disorders.
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Landin-Romero
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Sarró
authors.affiliation: Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Fernández-Corcuera
authors.affiliation: Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain.
authors.forename: Noemí
authors.initials: N
authors.lastname: Moro
authors.affiliation: CIBERSAM, Madrid, Spain; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Manuel Goikolea
authors.affiliation: Hospital Sant Rafael, Barcelona, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Isabel Carrión
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain.
authors.forename: Edith
authors.initials: E
authors.lastname: Pomarol-Clotet
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain. Electronic address: benedikt.amann@gmail.com.
authors.forename: Benedikt L
authors.initials: BL
authors.lastname: Amann
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM, Madrid, Spain; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, England.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Radua
mesh_terms: D000328:Adult; D001921:Brain / Q000002:abnormalities* / Q000503:physiopathology; D001927:Brain Diseases / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D016022:Case-Control Studies; D056344:Executive Function; D005260:Female; D006801:Humans; D007360:Intelligence; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology*; D015995:Prevalence; D011618:Psychotic Disorders / Q000209:etiology*; D012307:Risk Factors
keywords: Cavum vergae; Midline brain; Mood disorders; Psychotic disorders; Septum pellucidum; Structural MRI