title: Avoid Endoscopy in Children With Suspected Inflammatory Bowel Disease Who Have Normal Calprotectin Levels.
abstract: In children with suspected inflammatory bowel disease, adding calprotectin stool testing to the screening strategy has been recommended to distinguish organic from nonorganic disease. In this cohort study with historical controls, we could not confirm that screening with stool calprotectin improves the diagnostic yield (ratio inflammatory bowel disease-positive endoscopies and total number of endoscopies); however, in patients with normal fecal calprotectin levels (<50 μg/g) endoscopic and histological abnormalities were not seen. We propose to refrain from endoscopy when stool calprotectin levels are normal.
authors.affiliation: *Department of Pediatric Gastroenterology †Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
authors.forename: Anke
authors.initials: A
authors.lastname: Heida
authors.forename: Gea A
authors.initials: GA
authors.lastname: Holtman
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Lisman-van Leeuwen
authors.forename: Marjolein Y
authors.initials: MY
authors.lastname: Berger
authors.forename: Patrick F
authors.initials: PF
authors.lastname: van Rheenen
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002648:Child; D000066491:Clinical Decision-Making / Q000379:methods*; D000075202:Contraindications; D016099:Endoscopy, Gastrointestinal / Q000706:statistics & numerical data*; D005243:Feces / Q000737:chemistry; D005260:Female; D065386:Historically Controlled Study; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000601:surgery; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex