title: Tranexamic acid in the management of upper gastrointestinal bleeding: an evidence-based case report.
abstract: OBJECTIVE
  to review the effectiveness of tranexamic acid therapy which has been proposed to reduce bleeding and in turn lower mortality rate.
  
  
  METHODS
  following literature searching based on our clinical question on Cochrane Library, PubMed, Clinical Key, EBSCO, Science Direct and Proquest, one systematic review that includes seven randomized controlled trials is obtained. The article meets validity and relevance criteria.
  
  
  RESULTS
  the systematic review found that there is no any clear evidence between intervention and control groups in term of mortality.
  
  
  CONCLUSIONS
  the use of tranexamic acid to reduce mortality in patients with upper gastrointestinal bleeding is not recommended.
authors.affiliation: Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
authors.forename: Nur
authors.initials: N
authors.lastname: Atikah
authors.forename: Gurmeet
authors.initials: G
authors.lastname: Singh
authors.forename: Hasan
authors.initials: H
authors.lastname: Maulahela
authors.forename: Rahmat
authors.initials: R
authors.lastname: Cahyanur
mesh_terms: D019468:Disease Management; D019317:Evidence-Based Medicine; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000401:mortality*; D006801:Humans; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D014148:Tranexamic Acid