title: Synthesis, characterization and application of biodegradable crosslinked carboxymethyl chitosan/poly(vinyl alcohol) clay nanocomposites.
abstract: Crosslinked poly(vinyl alcohol) (PVA)/carboxymethyl chitosan (CMCh) nanocomposites were synthesized using terephthaloyl diisothiocyanate crosslinker, in the presence of montmorillonite (MMT), in different ratios of the two matrices. Characterization of nanocomposites was performed using different analyses. Swelling behavior was studied in different buffered solutions. It was found that formation of crosslinked CMCh/PVA hydrogels increased the swellability. Metal ion adsorption has also been investigated. The results indicated that crosslinked CMCh adsorbs various metal ions much more than non crosslinked CMCh. Antimicrobial activity was examined against Gram positive bacteria, against Gram negative bacteria, and also against fungi. Results indicated that most of these nanocomposites exhibited good antimicrobial potency. Degradation study was carried out in Simulated Body Fluid (SBF) for different time periods in order to find out degradation index (Di). Results showed that weight loss of most of the nanocomposites increased as a function of incubation time.
authors.affiliation: Department of Chemistry-Faculty of Science-Cairo University, Giza 12316, Egypt.
authors.forename: Magdy W
authors.initials: MW
authors.lastname: Sabaa
authors.affiliation: Department of Chemistry-Faculty of Science-Cairo University, Giza 12316, Egypt.
authors.forename: Heba M
authors.initials: HM
authors.lastname: Abdallah
authors.affiliation: Department of Chemistry-Faculty of Science-Cairo University, Giza 12316, Egypt.
authors.forename: Nadia A
authors.initials: NA
authors.lastname: Mohamed
authors.affiliation: Department of Chemistry-Faculty of Science-Cairo University, Giza 12316, Egypt. Electronic address: rihamrashad@hotmal.com.
authors.forename: Riham R
authors.initials: RR
authors.lastname: Mohamed
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry; D001546:Bentonite / Q000737:chemistry; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D000077215:Clay; D006090:Gram-Negative Bacteria / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000254:growth & development; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D011142:Polyvinyl Alcohol / Q000737:chemistry*
chemical_list: D000538:Aluminum Silicates; D000900:Anti-Bacterial Agents; D020100:Hydrogels; C514968:carboxymethyl-chitosan; D001546:Bentonite; D011142:Polyvinyl Alcohol; D048271:Chitosan; D000077215:Clay
keywords: Antimicrobial potency; Carboxymethyl chitosan; Nanocomposites; Poly(vinyl alcohol); Swelling