title: New ursane triterpenoids from Salvia urmiensis Bunge: Absolute configuration and anti-proliferative activity.
abstract: Two new triterpenoids, urmiensolide B (1) and urmiensic acid (2), with rare carbon skeletons together with three known compounds were isolated from the aerial parts of Salvia urmiensis Bunge, an endemic species of Iran. The structures were established by a combination of 1D and 2D NMR, and HRESIMS, and in the case of 2 and 3, their structures were confirmed by single-crystal X-ray analysis. The absolute configuration of 2 was established by electronic circular dichroism (ECD) spectra. The new compounds were evaluated for their anti-proliferative activities against A549 and MCF-7 human cancer cell lines. Compounds 1 and 2 showed IC50 values of 2.8 and 1.6 μM against MCF-7 cells, respectively.
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran. Electronic address: m_moridi@sbu.ac.ir.
authors.forename: Mahdi Moridi
authors.initials: MM
authors.lastname: Farimani
authors.affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mir Babak
authors.initials: MB
authors.lastname: Bahadori
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
authors.forename: Sheyda Ahmadi
authors.initials: SA
authors.lastname: Koulaei
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Salehi
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
authors.forename: Samad Nejad
authors.initials: SN
authors.lastname: Ebrahimi
authors.affiliation: Department of Chemistry, Faculty of Chemistry, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Khavasi
authors.affiliation: Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hamburger
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D007492:Iran; D061986:MCF-7 Cells; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D012632:Secosteroids / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012632:Secosteroids; D014315:Triterpenes; C000604471:urmiensic acid; C585008:urmiensolide; C000604472:urmiensolide B
keywords: Absolute configuration; Anti-proliferative activity; Salvia urmiensis; Triterpenoids