title: Difference in Time to Locoregional Recurrence Between Patients With Right-Sided and Left-Sided Colon Cancers.
abstract: BACKGROUND
  Locoregional recurrence rates after curative resection for colon cancer vary widely. Identification of factors associated with locoregional recurrence may help in patient management.
  
  
  OBJECTIVE
  The purpose of this study was to compare time to locoregional recurrence and distribution of locoregional recurrence after curative resection of colon cancer according to primary tumor location and to investigate risk factors for locoregional recurrence of colon cancer.
  
  
  METHODS
  This was a retrospective observational study.
  
  
  METHODS
  This study was conducted at a single institution.
  
  
  METHODS
  This study analyzed 1632 patients with colonic adenocarcinoma without distant metastasis who underwent curative resection at the National Cancer Center in Korea between January 2001 and December 2009. The primary end point of the study was time from surgery to locoregional recurrence. The Kaplan-Meier method was used to estimate the cumulative incidence of locoregional recurrence, and the log-rank test was used to test the difference in time to locoregional recurrence between patient subgroups. Cox proportional hazards models were used to investigate the risk factors for locoregional recurrence.
  
  
  METHODS
  The time from surgery to locoregional recurrence was compared between patients with right-sided and left-sided colon cancers.
  
  
  RESULTS
  The time to locoregional recurrence was significantly different between patients with right-sided and left-sided colon cancers (HR = 2.35 for right-sided; p < 0.001). The overall 5-year locoregional recurrence rate was 5.7%, and that in patients with right-sided and left-sided colon cancers was 8.5% and 4.1%. Multivariable analysis demonstrated that right-sided location, female sex, T4 disease, lymph node metastasis, and perineural invasion were independent risk factors for locoregional recurrence of colon cancer.
  
  
  CONCLUSIONS
  This was a retrospective design and single-institution study.
  
  
  CONCLUSIONS
  Patients with right-sided colon cancers presented with significantly increased risk of locoregional recurrence. Right-sided location, female sex, T4 disease, lymph node metastasis, and perineural invasion are independent risk factors for locoregional recurrence of colon cancer.
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea.
authors.forename: Jung Hun
authors.initials: JH
authors.lastname: Park
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Sung Chan
authors.initials: SC
authors.lastname: Park
authors.forename: Min Ju
authors.initials: MJ
authors.lastname: Kim
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Hong
authors.forename: Dae Kyung
authors.initials: DK
authors.lastname: Sohn
authors.forename: Kyung Su
authors.initials: KS
authors.lastname: Han
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Oh
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome