title: NLRP1 and NLRP3 polymorphisms in mesothelioma patients and asbestos exposed individuals a population-based autopsy study from North East Italy.
abstract: NRLP1 (rs12150220, rs9889625, rs9900356, rs6502867, rs2670660) and NLRP3 (rs35829419, rs10754558) polymorphisms have been analyzed in 69 subjects with documented asbestos exposure and death for malignant pleural mesothelioma and 59 patients with documented asbestos exposure but death for other causes, all from a North East Italy. No association was found between NLRP1 and NLRP3 polymorphisms and susceptibility to develop mesothelioma using the general, dominant or recessive models. Also haplotype analysis did not reveal any significant association with mesothelioma. Our findings, being controversial with respect to another study on Italian patients, do suggest the need of further studies to unravel the contribution of NLRP1 and NLRP3 in susceptibility to mesothelioma.
authors.affiliation: Department of Life Sciences, University of Trieste, Trieste, Italy.
authors.forename: Violetta
authors.initials: V
authors.lastname: Borelli
authors.affiliation: Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
authors.forename: Ronal R
authors.initials: RR
authors.lastname: Moura
authors.affiliation: Department of Life Sciences, University of Trieste, Trieste, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Trevisan
authors.affiliation: Department of Genetics, Federal University of Pernambuco, Recife, Brazil ; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
keywords: Asbestos exposure; Haplotypes; Inflammasome; Mesothelioma; NLRP1 and NLRP3 polymorphisms