title: Fatty liver and abdominal fat relationships with high C-reactive protein in adults without coronary heart disease.
abstract: OBJECTIVE
  Fatty liver (FL) and abdominal visceral fat (AVF) are strongly associated with systemic inflammation, however, it has not been defined if each one is independently involved, and if the insulin resistance is associated. To investigate if FL, AVF and insulin resistance are independently or additively associated with the high-sensitivity C-reactive protein (hs-CRP) in subjects without coronary artery disease we included 491 men and 553 women.
  
  
  METHODS
  All had anthropometric and plasma biochemical measurements, FL and AVF assessments by computed tomography.
  
  
  RESULTS
  The FL prevalence was 35.6% in men and 28.0% in women, p < 0.01. The prevalence of obesity, metabolic syndrome and homeostasis model assessment of insulin resistance (HOMA-IR) was significantly higher in FL compared to non FL subjects. FL and AVF accounted for 21 and 17%, respectively, to hs-CRP plasma levels. FL, AVF ≥ P75 and HOMA-IR ≥ P75 were independently and additively associated with plasma hs-CRP. The risk of hs-CRP ≥ 3 mg/L increased progressively in men from 1.36 (0.5-3.86) through 3.58 (1.32-9.7) in those with 1 or 3 factors respectively. In women from 2.25 (1.2-4.2) to 4.67 (2.3-9.4), respectively. In conclusion, both the FL and hs-CRP ≥ 3 mg/L occur in 1 of every 3 non CAD subjects. In men, FL and AVF ≥ P75 were associated with 3.6 times the risk of hs-CRP ≥ 3 mg/L, while in women, these factors were independently and additively associated with a 4.7 times higher risk of systemic inflammation.
authors.affiliation: Departamento de Endocrinología Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Guillermo C
authors.initials: GC
authors.lastname: Cardoso-Saldaña
authors.affiliation: Departamento de Endocrinología Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Aida X
authors.initials: AX
authors.lastname: Medina-Urrutia
authors.affiliation: Departamento de Endocrinología Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.affiliation: Departamento de Endocrinología Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Juan G
authors.initials: JG
authors.lastname: Juárez-Rojas
authors.affiliation: Departamento de Endocrinología Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Esteban
authors.initials: E
authors.lastname: Jorge-Galarza
authors.affiliation: Departamento de Biología Molecular. Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.affiliation: Departamento de Endocrinología Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism* / Q000503:physiopathology; D050154:Adiposity; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D018836:Inflammation Mediators / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein