title: A Healthy Dietary Pattern at Midlife, Combined with a Regulated Energy Intake, Is Related to Increased Odds for Healthy Aging.
abstract: BACKGROUND
  Few studies have investigated the long-term impact of overall dietary patterns (DPs) on healthy aging (HA), and current findings are inconsistent.
  
  
  OBJECTIVE
  Our study's objective was to investigate the association between empirically derived DPs in midlife and HA after 13 y of follow-up.
  
  
  METHODS
  Baseline dietary data from repeated 24-h dietary records (on average, 10 records per participant) of a subsample of the SU.VI.MAX (SUpplémentation en Vitamines et Minéraux AntioXydants) study allowed extraction of 2 DPs with the use of principal components analysis on 37 food groups. HA was assessed in 2007-2009 among 2796 participants of the SU.VI.MAX study aged 45-60 y at baseline (1994-1995), who were initially free of diabetes, cardiovascular disease, and cancer. HA was defined as not developing any major chronic disease, good physical and cognitive functioning, no limitations in instrumental activities of daily living, no depressive symptoms, no health-related limitations in social life, good overall self-perceived health, and no function-limiting pain. The association between DPs (in tertiles) and HA was evaluated by using multivariable logistic regression, and a potential interaction with energy intake was investigated.
  
  
  RESULTS
  A "Western" and a "healthy" DP were identified. After adjustment for a large number of potential confounders, there was no significant association between the Western DP and HA. Moreover, the healthy pattern was not associated with HA among subjects with high (i.e., greater than or equal to the median) energy intake. Among subjects with low (i.e., less than the median) energy intake, on the other hand, higher scores on the healthy DP were related to higher odds of HA (OR for tertile 3 vs. tertile 1: 1.49; 95% CI: 1.11, 2.00; P-trend = 0.01).
  
  
  CONCLUSIONS
  Adherence to a healthy diet in midlife that provides micronutrients, fiber, and antioxidants while regulating energy intake may help to promote HA.
authors.affiliation: University of Paris 13, Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research (INSERM) U1153, National Institute for Agricultural Research (INRA) U1125, National Conservatory of Arts and Crafts (CNAM), Community of Universities and Establishments (COMUE) Sorbonne Paris Cité, Bobigny, France; k.assmann@eren.smbh.univ-paris13.fr.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Assmann
authors.affiliation: University of Paris 13, Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research (INSERM) U1153, National Institute for Agricultural Research (INRA) U1125, National Conservatory of Arts and Crafts (CNAM), Community of Universities and Establishments (COMUE) Sorbonne Paris Cité, Bobigny, France;
authors.forename: Camille
authors.initials: C
authors.lastname: Lassale
authors.affiliation: University of Paris 13, Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research (INSERM) U1153, National Institute for Agricultural Research (INRA) U1125, National Conservatory of Arts and Crafts (CNAM), Community of Universities and Establishments (COMUE) Sorbonne Paris Cité, Bobigny, France;
authors.forename: Valentina A
authors.initials: VA
authors.lastname: Andreeva
authors.affiliation: Department of Geriatrics, Centre Balmès, CHU Montpellier, Université Montpellier I, Montpellier, France; and.
authors.forename: Claude
authors.initials: C
authors.lastname: Jeandel
authors.affiliation: University of Paris 13, Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research (INSERM) U1153, National Institute for Agricultural Research (INRA) U1125, National Conservatory of Arts and Crafts (CNAM), Community of Universities and Establishments (COMUE) Sorbonne Paris Cité, Bobigny, France; Department of Public Health, Hôpital Avicenne, Bobigny, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
authors.affiliation: University of Paris 13, Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research (INSERM) U1153, National Institute for Agricultural Research (INRA) U1125, National Conservatory of Arts and Crafts (CNAM), Community of Universities and Establishments (COMUE) Sorbonne Paris Cité, Bobigny, France;
authors.forename: Pilar
authors.initials: P
authors.lastname: Galan
authors.affiliation: University of Paris 13, Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research (INSERM) U1153, National Institute for Agricultural Research (INRA) U1125, National Conservatory of Arts and Crafts (CNAM), Community of Universities and Establishments (COMUE) Sorbonne Paris Cité, Bobigny, France;
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Kesse-Guyot
mesh_terms: D000203:Activities of Daily Living; D000375:Aging; D000975:Antioxidants / Q000008:administration & dosage; D001069:Appetite Regulation; D003071:Cognition; D015930:Diet Records; D066273:Diet, Western; D004043:Dietary Fiber / Q000008:administration & dosage; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D015438:Health Behavior; D006293:Health Promotion; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000975:Antioxidants; D004043:Dietary Fiber; D018977:Micronutrients
keywords: dietary patterns; energy intake; healthy aging; midlife exposure; nutrition