title: Palladium-Catalyzed Domino Synthesis of 4-Amino-3-acyl-2- naphthols via Isocyanide Chemoselective Insertion.
abstract: A novel and efficient strategy for the synthesis of sterically hindered 4-amino-3-acyl-2-naphthols through a palladium-catalyzed coupling reaction involving isocyanide chemselective insertion and domino isomerization has been developed. The methodology, which is in accordance with the principle of "atom and step economy", efficiently constructs 4-amino-3-acyl-2-naphthols in moderate to good yields.
authors.affiliation: †College of Pharmaceutical Science and ‡College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: †College of Pharmaceutical Science and ‡College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
authors.forename: Hua-Qing
authors.initials: HQ
authors.lastname: Duan
authors.affiliation: †College of Pharmaceutical Science and ‡College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Jiang
authors.affiliation: †College of Pharmaceutical Science and ‡College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Zhu
authors.affiliation: †College of Pharmaceutical Science and ‡College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji
authors.affiliation: †College of Pharmaceutical Science and ‡College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Yang
mesh_terms: D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D007536:Isomerism; D015394:Molecular Structure; D009284:Naphthols / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*
chemical_list: D003486:Cyanides; D009284:Naphthols; D010165:Palladium