title: Association between abdominal fat distribution, adipocytokines and metabolic alterations in obese low-birth-weight children.
abstract: In addition to obesity, low birth weight (LBW) has been proposed as another independent risk factor associated with cardiovascular disease and type 2 diabetes mellitus.
  
  
  
  This study aimed to evaluate the influence of birth weight on abdominal fat distribution, adipocytokine levels and associated metabolic alterations in obese children.
  
  
  
  A cross-sectional study was conducted in 92 children. Children were divided into three groups according to their body mass index and birth weight. Glucose and insulin (0 and 120 min), lipid profile and adipocytokines were measured. Abdominal fat distribution was assessed by magnetic resonance imaging.
  
  
  
  Obese LBW children had higher fasting glucose (P = 0.054) and insulin (P < 0.001), and 120 min glucose (P < 0.001) and insulin levels (P < 0.001), such as increased HOMA-IR (homeostasis model assessment of insulin resistance index) (P < 0.001). Obesity and LBW were associated with lower concentrations of high molecular weight (HMW) adiponectin (-2.38 [IC 95% -4.27; -0.42, P = 0.018]) and higher subcutaneous adipose tissue (SAT) (28.05 [IC 95% 0.40; 55.7, P = 0.047]) compared with NBW obese children, independent of age or sex.
  
  
  
  LBW in obese children is associated with lower HMW adiponectin, increased insulin resistance and greater SAT.
authors.affiliation: Endocrinology Department, Hospital Infantil de México Federico Gómez, Distrito Federal, Mexico.
authors.forename: C
authors.initials: C
authors.lastname: Domínguez Hernández
authors.affiliation: Community Health Research Department, Hospital Infantil de México Federico Gómez, Distrito Federal, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Klünder Klünder
authors.affiliation: Pharmacology Department, Hospital Infantil de México Federico Gómez, Distrito Federal, Mexico.
authors.forename: F
authors.initials: F
authors.lastname: Huang
authors.affiliation: Radiology Department, Hospital Infantil de México Federico Gómez, Distrito Federal, Mexico.
authors.forename: E M
authors.initials: EM
authors.lastname: Flores Armas
authors.affiliation: Clinical Epidemiology Research Unit, Hospital Regional General No. 1 Carlos McGregor Sánchez-Navarro, Instituto Mexicano del Seguro Social, Distrito Federal, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Velázquez-López
authors.affiliation: Endocrinology Department, Hospital Infantil de México Federico Gómez, Distrito Federal, Mexico.
authors.forename: P
authors.initials: P
authors.lastname: Medina-Bravo
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D054392:Adipokines / Q000097:blood*; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D063766:Pediatric Obesity / Q000378:metabolism*
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids
keywords: abdominal adipose tissue; adipocytokines; childhood obesity; fetal programming