title: A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia.
abstract: Two articles in this issue (Intlekofer et al., 2015; Oldham et al., 2015) show a new metabolic pathway regulated by hypoxia, but independently of HIF1 or HIF2. L-2-hydroxyglutarate, produced in hypoxia by malate dehydrogenases and LDHA, is a potent inhibitor of KDM4C, and through redox stress reduces glycolysis.
authors.affiliation: Molecular Oncology Laboratories, Oxford University Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS UK. Electronic address: adrian.harris@oncology.ox.ac.uk.
authors.forename: Adrian L
authors.initials: AL
authors.lastname: Harris