title: Papillomavirus Infectious Pathways: A Comparison of Systems.
abstract: The HPV viral lifecycle is tightly linked to the host cell differentiation, causing difficulty in growing virions in culture. A system that bypasses the need for differentiating epithelium has allowed for generation of recombinant particles, such as virus-like particles (VLPs), pseudovirions (PsV), and quasivirions (QV). Much of the research looking at the HPV life cycle, infectivity, and structure has been generated utilizing recombinant particles. While recombinant particles have proven to be invaluable, allowing for a rapid progression of the HPV field, there are some significant differences between recombinant particles and native virions and very few comparative studies using native virions to confirm results are done. This review serves to address the conflicting data in the HPV field regarding native virions and recombinant particles.
authors.affiliation: Department of Microbiology and Immunology, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. jhopkins@hmc.psu.edu.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Biryukov
authors.affiliation: Department of Microbiology and Immunology, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. cmm10@psu.edu.
authors.forename: Craig
authors.initials: C
authors.lastname: Meyers
mesh_terms: D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D011995:Recombination, Genetic; D014771:Virion / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D014773:Virology / Q000379:methods*; D014776:Virus Cultivation / Q000379:methods
keywords: human papillomavirus (HPV); native virions (NV); pseudovirions (PsV); quasivirions (QV); virus; virus-like particles (VLPs)