title: The diagnostic value of tumor markers in bronchoalveolar lavage fluid for the peripheral pulmonary carcinoma.
abstract: BACKGROUND
  To investigate the value of Ubiquitin specific peptidase 8 (USP8), Chitinase 3-like 1 (YKL40), Heat shock protein 90a (HSP90α), glutathione S-transferase P1 (GSTP1), carcinoembryonic antigen (CEA), neuron specific enolase (NSE) and cytokeratin fragment antiogen 21-1 (CYFRA21-1) in bronchoalveolar lavage fluid (BALF) and serum for diagnosis in patients with peripheral lung cancer.
  
  
  METHODS
  The concentration of these markers were measured in 50 patients with peripheral lung cancer and 50 patients with benign lung diseases by using enzyme-linked immuno sorbent assay methods.
  
  
  RESULTS
  There were significant differences between the peripheral lung cancer group and the benign lung disease group (P < 0.05) in the BALF of USP8, YKL40, HSP90α, CEA, NSE and CYFRA21-1. There were significant differences between the peripheral lung cancer group and the benign lung disease group (P < 0.05) in the serum of HSP90α and CEA. There were no differences in others. There were no correlation between the concentration of all markers and age, histological type, TNM stage (I-IV). There was a weak correlation between the primary foci diameters and the concentration of YKL40 in BALF. (Pearson's correlation: 0.203, P = 0.048) The diagnostic efficiencies of USP8, YKL40, HSP90α were superior to CYFRA21-1 and NSE, being lower CEA.
  
  
  CONCLUSIONS
  Detection of tumor markers in BALF was superior to serum specimens. The measurement of USP8, HSP90α and YKL40 in BALF had more clinical value for the diagnosis of peripheral pulmonary carcinoma.
authors.affiliation: Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Pudong New Area Gongli Hospital, Shanghai, 200135, China.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zhao
authors.affiliation: Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors.forename: Ming-Zhou
authors.initials: MZ
authors.lastname: Zhang
authors.affiliation: Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors.forename: Xue-Ling
authors.initials: XL
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood* / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002272:Carcinoembryonic Antigen / Q000097:blood / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D000071451:Chitinase-3-Like Protein 1 / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism; D005260:Female; D051549:Glutathione S-Transferase pi / Q000097:blood / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000097:blood / Q000378:metabolism; D006801:Humans; D053539:Keratin-19 / Q000097:blood / Q000378:metabolism; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010751:Phosphopyruvate Hydratase / Q000097:blood / Q000378:metabolism; D043222:Ubiquitin Thiolesterase / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C084533:CHI3L1 protein, human; D002272:Carcinoembryonic Antigen; D000071451:Chitinase-3-Like Protein 1; D056827:Endosomal Sorting Complexes Required for Transport; D018841:HSP90 Heat-Shock Proteins; C533585:HSP90AA2P protein, human; D053539:Keratin-19; C102012:antigen CYFRA21.1; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D010450:Endopeptidases; C541534:USP8 protein, human; D043222:Ubiquitin Thiolesterase; D010751:Phosphopyruvate Hydratase
keywords: bronchoalveolar lavage fluid - marker - peripheral pulmonary carcinoma - diagnosis