title: Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.
abstract: N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized (13)C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its (13)C chemical shift within the physiologic range.
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158, USA. David.m.wilson@ucsf.edu.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Flavell
authors.forename: Cornelius
authors.initials: C
authors.lastname: von Morze
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Blecha
authors.forename: David E
authors.initials: DE
authors.lastname: Korenchan
authors.forename: Mark
authors.initials: M
authors.lastname: Van Criekinge
authors.forename: Renuka
authors.initials: R
authors.lastname: Sriram
authors.forename: Jeremy W
authors.initials: JW
authors.lastname: Gordon
authors.forename: Hsin-Yu
authors.initials: HY
authors.lastname: Chen
authors.forename: Sukumar
authors.initials: S
authors.lastname: Subramaniam
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bok
authors.forename: Zhen J
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Vigneron
authors.forename: Peder E
authors.initials: PE
authors.lastname: Larson
authors.forename: John
authors.initials: J
authors.lastname: Kurhanewicz
authors.forename: David M
authors.initials: DM
authors.lastname: Wilson
mesh_terms: D002021:Buffers; D002247:Carbon Isotopes; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D013654:Taurine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D002021:Buffers; D002247:Carbon Isotopes; D013654:Taurine; C024789:N-(2-acetamido)-2-aminoethanesulfonic acid