title: Telogen elongation in the hair cycle of ob/ob mice.
abstract: Alopecia impairs the physical and mental health of patients. We have previously shown that 8-week-old ob/ob mice have no reactivity to depilation, which is a stimulus that induces anagen transition in normal mice, while no hair cycle abnormalities have been reported in other studies until mice reach 7 weeks of age. Therefore, we hypothesized that ob/ob mice have abnormalities in hair cycle progression beyond 7 weeks of age. We examined 6- to 24-week-old ob/ob and 6- to 10-week-old normal mice. After acclimation, the dorsal skin was harvested and the hair cycle phase was identified histologically and immunohistochemically. Normal mice showed catagen-telogen and telogen-anagen transitions at 6 and 8-9 weeks old, respectively. In contrast, the anagen-catagen transition was observed in 7-week-old mice and the telogen phase was maintained from 10 to 24 weeks in most ob/ob mice. These results suggests that ob/ob mice are a possible model animal for telogen effluvium.
authors.affiliation: a Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine , The University of Tokyo , Tokyo , Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Tasaki
authors.affiliation: a Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine , The University of Tokyo , Tokyo , Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Minematsu
authors.affiliation: a Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine , The University of Tokyo , Tokyo , Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Mugita
authors.affiliation: a Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine , The University of Tokyo , Tokyo , Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Ikeda
authors.affiliation: a Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine , The University of Tokyo , Tokyo , Japan.
authors.forename: Gojiro
authors.initials: G
authors.lastname: Nakagami
authors.affiliation: a Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine , The University of Tokyo , Tokyo , Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sanada
mesh_terms: D000367:Age Factors; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D000505:Alopecia / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D015870:Gene Expression; D018859:Hair Follicle / Q000254:growth & development / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008820:Mice, Obese; D012880:Skin Pigmentation
chemical_list: D015415:Biomarkers; D019394:Ki-67 Antigen; C498355:Mki67 protein, mouse
keywords: alopecia; hair cycle; metabolic syndrome; mouse