title: Novel nanoparticle vaccines for Listeriosis.
abstract: In recent years, nanomedicine has transformed many areas of traditional medicine, and enabled fresh insights into the prevention of previously difficult to treat diseases. An example of the transformative power of nanomedicine is a recent nano-vaccine against listeriosis, a serious bacterial infection affecting not only pregnant women and their neonates, but also immune-compromised patients with neoplastic or chronic autoimmune diseases. There is a major unmet need for an effective and safe vaccine against listeriosis, with the challenge that an effective vaccine needs to generate protective T cell immunity, a hitherto difficult to achieve objective. Now utilizing a gold nanoparticle antigen delivery approach together with a novel polysaccharide nanoparticulate adjuvant, an effective T-cell vaccine has been developed that provides robust protection in animal models of listeriosis, raising the hope that one day this nanovaccine technology may protect immune-compromised humans against this serious opportunistic infection.
authors.affiliation: a Grupo de Genómica; Proteómica y Vacunas; Instituto de Investigación Marqués de Valdecilla ; Santander , Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Calderon-Gonzalez
authors.affiliation: b Fundacion Cidetc; Parque Tecnológico ; San Sebastian , Spain.
authors.forename: Marco
authors.initials: M
authors.lastname: Marradi
authors.affiliation: c CIC-biomaGUNE; Parque Tecnologico ; San Sebastian , Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Garcia
authors.affiliation: d Flinders University ; Adelaide , Australia.|e Vaxine Ltd.; Flinders Medical Center ; Adelaide , Australia.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Petrovsky
authors.affiliation: a Grupo de Genómica; Proteómica y Vacunas; Instituto de Investigación Marqués de Valdecilla ; Santander , Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Alvarez-Dominguez
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology* / Q000302:isolation & purification; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006046:Gold / Q000008:administration & dosage; D008088:Listeriosis / Q000276:immunology / Q000517:prevention & control*; D053758:Nanoparticles / Q000008:administration & dosage*; D011134:Polysaccharides / Q000008:administration & dosage; D013601:T-Lymphocytes / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D004337:Drug Carriers; D011134:Polysaccharides; D006046:Gold
keywords: LLO peptide; Listeria; adjuvant; nanoparticles; vaccine