title: Mechanisms of a novel anticancer therapeutic strategy involving atmospheric pressure plasma-mediated apoptosis and DNA strand break formation.
abstract: Atmospheric pressure plasma has been developed for a variety of biomedical applications due to its chemically reactive components. Recently, the plasma has emerged as a promising novel cancer therapy based on its ability to selectively ablate cancer cells while leaving normal cells essentially unaffected. The therapeutic effect of plasma is attributed to intracellular generation of reactive oxygen/nitrogen species (ROS/RNS) leading to mitochondria-mediated apoptosis and to activation of the DNA damage checkpoint signaling pathway via severe DNA strand break formation. However, the biochemical mechanisms responsible for appropriate activation of these physiological events and which pathway is more crucial for plasma-mediated cytotoxicity have not been clarified. Understanding the molecular link between ROS/RNS-mediated apoptosis and DNA damage-involved chromosome instability is critical for the development of more efficacious therapeutic strategies for selective killing of diverse cancer cells.
authors.affiliation: College of Pharmacy, Duksung Women's University, 33, Samyangro 144-gil, Dobong-gu, Seoul, 132-714, Korea. whchung23@duksung.ac.kr.|Innovative Drug Center, Duksung Women's University, Seoul, 132-714, Korea. whchung23@duksung.ac.kr.
authors.forename: Woo-Hyun
authors.initials: WH
authors.lastname: Chung
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001274:Atmospheric Pressure; D053960:DNA Breaks; D004249:DNA Damage / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy*; D010949:Plasma / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species
keywords: Anticancer therapy; Apoptosis; Atmospheric pressure plasma; DNA strand break; ROS/RNS generation