title: A Practical Guide for Exploring Opportunities of Repurposing Drugs for CNS Diseases in Systems Biology.
abstract: Systems biology has shown its potential in facilitating pathway-focused therapy development for central nervous system (CNS) diseases. An integrated network can be utilized to explore the multiple disease mechanisms and to discover repositioning opportunities. This review covers current therapeutic gaps for CNS diseases and the role of systems biology in pharmaceutical industry. We conclude with a Multiple Level Network Modeling (MLNM) example to illustrate the great potential of systems biology for CNS diseases. The system focuses on the benefit and practical applications in pathway centric therapy and drug repositioning.
authors.affiliation: Informatics and Structure Biology, R&D China, GlaxoSmithKline, 917 Halei Road, Shanghai, 201203, China.
authors.forename: Hongkang
authors.initials: H
authors.lastname: Mei
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Jason
authors.initials: J
authors.lastname: Zhu
authors.forename: Simon
authors.initials: S
authors.lastname: Lin
authors.forename: Yang
authors.initials: Y
authors.lastname: Qiu
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Tian
authors.initials: T
authors.lastname: Xia
mesh_terms: D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D058492:Drug Repositioning / Q000379:methods*; D006801:Humans; D017410:Practice Guidelines as Topic; D049490:Systems Biology / Q000379:methods*