title: Photo-responsive shell cross-linked micelles based on carboxymethyl chitosan and their application in controlled release of pesticide.
abstract: An amphiphilic carboxymethyl chitosan conjugate with photolabile 2-nitrobenzyl side groups (NBS-CMCS) was synthesized, which could self-assemble into polymeric micelles in aqueous condition following by adding dropwise dialdehyde to form a cross-linking structure. TEM and (1)H NMR confirmed that the cross-linked micelles had a core-shell configuration with an average diameter of 140 ± 5.5 nm. DLS and TEM observations showed that the cross-linked micelles were stable in aqueous solution at pH 7.0 without light irradiation, while they could transfer into nanocapsules upon exposure to 365 nm UV light. Diuron, a photosynthetic inhibitor, was encapsulated in the cross-linked micelles reaching encapsulation efficiency as much as 91.9%. No release of the encapsulated diuron was detected without light, whereas a release rate as high as 96.8% over 8h at pH 7.0 buffer was observed under solar stimulated irradiation, indicating that the cross-linked micelles may be used as a photo-controlled sustained release carrier for the delivery of photosynthetic inhibitor.
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
authors.forename: Dewei
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Tan
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Xiong
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China. Electronic address: yihuayin@aliyun.com.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China. Electronic address: guanghuahe@126.com.
authors.forename: Guanghua
authors.initials: G
authors.lastname: He
mesh_terms: D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D004237:Diuron / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D053769:Nanocapsules / Q000737:chemistry / Q000648:ultrastructure; D010575:Pesticides / Q000737:chemistry* / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004337:Drug Carriers; D008823:Micelles; D053769:Nanocapsules; D010575:Pesticides; C514968:carboxymethyl-chitosan; D048271:Chitosan; D004237:Diuron
keywords: Carboxymethyl chitosan; Core–shell micelles; Pesticide delivery; Photo-responsibility