title: Younger Stroke Patients With Large Pretreatment Diffusion-Weighted Imaging Lesions May Benefit From Endovascular Treatment.
abstract: OBJECTIVE
  Lesion volume on diffusion-weighted magnetic resonance imaging (DWI) before acute stroke therapy is a predictor of outcome. Therefore, patients with large volumes are often excluded from therapy. The aim of this study was to analyze the impact of endovascular treatment in patients with large DWI lesion volumes (>70 mL).
  
  
  METHODS
  Three hundred seventy-two patients with middle cerebral or internal carotid artery occlusions examined with magnetic resonance imaging before treatment since 2004 were included. Baseline data and 3 months outcome were recorded prospectively. DWI lesion volumes were measured semiautomatically.
  
  
  RESULTS
  One hundred five patients had lesions >70 mL. Overall, the volume of DWI lesions was an independent predictor of unfavorable outcome, survival, and symptomatic intracerebral hemorrhage (P<0.001 each). In patients with DWI lesions >70 mL, 11 of 31 (35.5%) reached favorable outcome (modified Rankin scale score, 0-2) after thrombolysis in cerebral infarction 2b-3 reperfusion in contrast to 3 of 35 (8.6%) after thrombolysis in cerebral infarction 0-2a reperfusion (P=0.014). Reperfusion success, patient age, and DWI lesion volume were independent predictors of outcome in patients with DWI lesions >70 mL. Thirteen of 66 (19.7%) patients with lesions >70 mL had symptomatic intracerebral hemorrhage with a trend for reduced risk with avoidance of thrombolytic agents.
  
  
  CONCLUSIONS
  There was a growing risk for poor outcome and symptomatic intracerebral hemorrhage with increasing pretreatment DWI lesion volumes. Nevertheless, favorable outcome was achieved in every third patient with DWI lesions >70 mL after successful endovascular reperfusion, whereas after poor or failed reperfusion, outcome was favorable in only every 12th patient. Therefore, endovascular treatment might be considered in patients with large DWI lesions, especially in younger patients.
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Marc D
authors.initials: MD
authors.lastname: Gilgen
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Dariusz
authors.initials: D
authors.lastname: Klimek
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Kai T
authors.initials: KT
authors.lastname: Liesirova
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Julia
authors.initials: J
authors.lastname: Meisterernst
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Pascal P
authors.initials: PP
authors.lastname: Klinger-Gratz
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.). gerhard.schroth@insel.ch.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schroth
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Pasquale
authors.initials: P
authors.lastname: Mordasini
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Kety
authors.initials: K
authors.lastname: Hsieh
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Johannes
authors.initials: J
authors.lastname: Slotboom
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Mirjam R
authors.initials: MR
authors.lastname: Heldner
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Anne
authors.initials: A
authors.lastname: Broeg-Morvay
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Marie-Luise
authors.initials: ML
authors.lastname: Mono
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Urs
authors.initials: U
authors.lastname: Fischer
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Heinrich P
authors.initials: HP
authors.lastname: Mattle
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Marcel
authors.initials: M
authors.lastname: Arnold
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Jan
authors.initials: J
authors.lastname: Gralla
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Marwan
authors.initials: M
authors.lastname: El-Koussy
authors.affiliation: From the Department of Diagnostic and Interventional Neuroradiology (M.D.G., D.K., P.P.K.-G., G.S., P.M., K.H., J.S., J.G., M.E.-K., S.J.) and Department of Neurology, Inselspital (M.D.G., K.T.L., J.M., M.R.H., A.B.-M., M.-L.M., U.F., H.P.M., M.A., S.J.), University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Radiology, University of Basel, Basel (P.P.K.-G.).
authors.forename: Simon
authors.initials: S
authors.lastname: Jung
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000473:pathology; D002343:Carotid Artery, Internal / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology; D002544:Cerebral Infarction / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology; D017063:Outcome Assessment, Health Care; D012042:Registries; D012720:Severity of Illness Index; D015912:Thrombolytic Therapy / Q000379:methods*
keywords: carotid artery internal; cerebral hemorrhage; diffusion; endovascular therapy; magnetic resonance imaging; reperfusion; stroke