title: Building stomach in a dish.
abstract: Modelling organs in culture has great potential to improve our understanding of development, organogenesis and disease. While some endodermal derived organs have been modelled, the corpus region of the stomach, where acid-producing cells reside, remained an invincible target. A 60-day differentiation protocol now enables the generation of functional acid-producing cells in culture, conquering the challenge.
authors.affiliation: 1] Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge CB2 1QN, UK [2] Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK [3] Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Huch
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000502:physiology*; D044968:Regenerative Medicine / Q000379:methods*; D013270:Stomach / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*