title: Quality of Life and Cost-Effectiveness Assessment of Radioiodine Ablation Strategies in Patients With Thyroid Cancer: Results From the Randomized Phase III ESTIMABL Trial.
abstract: OBJECTIVE
  In the ESTIMABL phase III trial, the thyroid ablation rate was equivalent for the two thyroid-stimulating hormone (TSH) stimulation methods (thyroid hormone withdrawal [THW] and recombinant human TSH [rhTSH]) and the two iodine-131 ((131)I) activities (1.1 or 3.7 GBq). The objectives of this article were to present health-related quality-of-life (HRQoL) results and a cost-effectiveness evaluation performed alongside this trial.
  
  
  METHODS
  HRQoL and utility were longitudinally assessed, from random assignment to the follow-up visit at 8 ± 2 months for the 752 patients with thyroid cancer, using the Short Form-36 and the EuroQoL-5D questionnaires, respectively. A cost-effectiveness analysis was performed from the societal perspective in the French context. Resource use (hospitalization for (131)I administration, rhTSH, sick leaves, and transportation) was collected prospectively. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for both TSH stimulation methods and (131)I activities. Sensitivity analyses of the costs of rhTSH were performed.
  
  
  RESULTS
  At (131)I administration, THW caused a clinically significant deterioration of HRQoL, whereas HRQoL remained stable with rhTSH. This deterioration was transient with no difference 3 months later. rhTSH was more effective than THW in terms of quality-adjusted life-years (QALYs; +0.013 QALY/patient) but more expensive (+€474/patient). The probability that rhTSH would be cost effective at a €50,000/QALY threshold was 47% in France. The use of 1.1 GBq of (131)I instead of 3.7 GBq reduced per-patient costs by €955 (US$1,018) but with slightly decreased efficacy (-0.007 QALY/patient).
  
  
  CONCLUSIONS
  rhTSH avoids the transient THW-induced deterioration of HRQoL but is unlikely to be cost effective at its current price.
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France. isabelle.borget@gustaveroussy.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Borget
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Bonastre
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Catargi
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Désirée
authors.initials: D
authors.lastname: Déandréis
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Slimane
authors.initials: S
authors.lastname: Zerdoud
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Daniela
authors.initials: D
authors.lastname: Rusu
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bardet
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Leenhardt
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Bastie
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Schvartz
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Vera
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Morel
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Daniele
authors.initials: D
authors.lastname: Benisvy
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Bournaud
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Francoise
authors.initials: F
authors.lastname: Bonichon
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Antony
authors.initials: A
authors.lastname: Kelly
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Toubert
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Leboulleux
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Journeau
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Ellen
authors.initials: E
authors.lastname: Benhamou
authors.affiliation: Isabelle Borget, Julia Bonastre, Désirée Déandréis, Sophie Leboulleux, Florence Journeau, Ellen Benhamou, and Martin Schlumberger, Gustave Roussy, Villejuif; Isabelle Borget, Julia Bonastre, and Ellen Benhamou, Center for Research in Epidemiology and Population Health, L'Institut National de la Santé et de la Recherche Médicale 1018; Isabelle Borget and Martin Schlumberger, University Paris-Sud; Laurence Leenhardt, Hôpital Pitié-Salpétrière; Marie-Elisabeth Toubert, Hôpital Saint-Louis, Paris; Bogdan Catargi, Centre Hospitalier Universitaire (CHU) Bordeaux; Francoise Bonichon, Institut Bergonié, Bordeaux; Slimane Zerdoud, Centre Claudius Regaud; Delphine Bastie, CHU Toulouse, Toulouse; Daniela Rusu, Centre René Gauducheau, Nantes; Stéphane Bardet, Centre François Baclesse, Caen; Claire Schvartz, Institut Jean Godinot, Reims; Pierre Vera, Centre Becquerel, Rouen; Olivier Morel, Institut de Cancérologie de l'Ouest, Paul Papin, Angers; Daniele Benisvy, Centre Lacassagne, Nice; Claire Bournaud, CHU Lyon, Lyon; and Antony Kelly, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Schlumberger
mesh_terms: D003362:Cost-Benefit Analysis; D006295:Health Resources; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D011994:Recombinant Proteins / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000523:psychology / Q000532:radiotherapy*; D013972:Thyrotropin / Q000627:therapeutic use
chemical_list: D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin