title: Association of family risk and lifestyle/comorbidities in ovarian cancer patients.
abstract: OBJECTIVE
  to analyze factors that might indicate familial predisposition for ovarian cancer in patients diagnosed with this disease.
  
  
  METHODS
  in a prospective single center cohort study at the Institute of Cancer of the State of São Paulo (ICESP), 51 women diagnosed with ovarian cancer were included. Familial predisposition for ovarian cancer was defined as having a higher than 10% chance of having a BRCA1/2 mutation according to the Manchester scoring system, a validated method to assess the likelihood of mutation detection. Each patient was interviewed with a standardized questionnaire on established risk factors for ovarian cancer and other factors that might influence the risk to develop ovarian cancer. Logistic regression analyses were performed to estimate the impact of the evaluated factors on the likelihood of mutation detection, by calculating odds ratios and 95% confidence intervals.
  
  
  RESULTS
  seventeen out of 51 patients had a family history of breast and/or ovarian cancer, four patients had a history of breast or endometrial cancer, 11 were diagnosed before the age of 50, and 12 presented a risk of familial predisposition to ovarian cancer higher than 10%. Patients with comorbidities, such as hypertension, diabetes, hormonal disorders, dyslipidemia and psychiatric conditions, presented a lower chance of having a familial predisposition for ovarian cancer (OR: 0.22; 95% CI: 0.06-0.88; p=0.03).
  
  
  CONCLUSIONS
  in this study, having comorbidities was associated with a lower risk of having a familial predisposition for ovarian cancer. Other factors associated with the risk of ovarian cancer did not have an impact on this predisposition.
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Natália
authors.initials: N
authors.lastname: Teixeira
authors.affiliation: Departamento de Radiologia e Oncologia, FM, USP, São Paulo, SP, Brazil.
authors.forename: Maria Aparecida Azevedo Koike
authors.initials: MA
authors.lastname: Folgueira
authors.affiliation: Laboratório de Oncologia Experimental, FM, USP, São Paulo, SP, Brazil.
authors.forename: Simone
authors.initials: S
authors.lastname: Maistro
authors.affiliation: Laboratório de Oncologia Experimental, FM, USP, São Paulo, SP, Brazil.
authors.forename: Giselly
authors.initials: G
authors.lastname: Encinas
authors.affiliation: Department of Cancer Epidemiology, University of Groningen, Groningen, Netherlands.
authors.forename: Geertruida Hendrika de
authors.initials: GH
authors.lastname: Bock
authors.affiliation: Division of Clinical Oncology, Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, São Paulo, SP, Brazil.
authors.forename: Maria Del Pilar Estevez
authors.initials: Mdel P
authors.lastname: Diz
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D015897:Comorbidity; D018284:Cystadenocarcinoma, Serous / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D061325:Hereditary Breast and Ovarian Cancer Syndrome / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008019:Life Style; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires