title: Primary drug resistance in a region with high burden of tuberculosis. A critical problem.
abstract: OBJECTIVE
  To determine rates of drug resistance in new cases of pulmonary tuberculosis in a region with a high burden of the disease.
  
  
  METHODS
  New case suspects were referred for drug susceptibility testing.
  
  
  RESULTS
  28.9% of new cases were resistant to at least one first line drug; 3.9% had a multidrug-resistant strain, 15.6% a monoresistant strain and 9.4% a polyresistant strain.
  
  
  CONCLUSIONS
  Our rate of drug resistant tuberculosis in new cases is very high; this has important clinical implications, since even monoresistance can have a negative impact on the outcome of new cases treated empirically with a six month regimen.
authors.affiliation: Clínica y Laboratorio de Tuberculosis, Hospital General de Tijuana, Instituto de Servicios de Salud Pública del Estado de Baja California, Mexicali, Baja California, México.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Villa-Rosas
authors.affiliation: Clínica y Laboratorio de Tuberculosis, Hospital General de Tijuana, Instituto de Servicios de Salud Pública del Estado de Baja California, Mexicali, Baja California, México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Laniado-Laborín
authors.affiliation: Clínica y Laboratorio de Tuberculosis, Hospital General de Tijuana, Instituto de Servicios de Salud Pública del Estado de Baja California, Mexicali, Baja California, México.
authors.forename: Lorena
authors.initials: L
authors.lastname: Oceguera-Palao
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology; D015897:Comorbidity; D004352:Drug Resistance, Microbial; D024901:Drug Resistance, Multiple, Bacterial; D019353:Endemic Diseases; D005260:Female; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents