title: Fluorescently labelled glycans and their applications.
abstract: This review summarises the literature on the synthesis and applications of fluorescently labelled carbohydrates. Due to the sensitivity of fluorescent detection, this approach provides a useful tool to study processes involving glycans. A few general categories of labelling are presented, in situ labelling of carbohydrates with fluorophores, fluorescently labelled glycolipids, fluorogenic glycans, pre-formed fluorescent glycans for intracellular applications, glycan-decorated fluorescent polymers, fluorescent glyconanoparticles, and other functional fluorescent glycans.
authors.affiliation: Department of Chemistry, Brock University, 500 Glenridge Ave., St. Catharines, ON, L2S 3A1, Canada. tyan@brocku.ca.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Chemistry, Brock University, 500 Glenridge Ave., St. Catharines, ON, L2S 3A1, Canada.
authors.forename: Ravi Shekar
authors.initials: RS
authors.lastname: Yalagala
authors.affiliation: Sussex Research Laboratories Inc., 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada.
authors.forename: Fengyang
authors.initials: F
authors.lastname: Yan
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D001896:Boron Compounds / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006017:Glycolipids / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D007477:Ions; D037102:Lectins / Q000737:chemistry; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D001897:Boronic Acids; D002241:Carbohydrates; D005456:Fluorescent Dyes; D006017:Glycolipids; D006027:Glycosides; D007477:Ions; D037102:Lectins; D011108:Polymers; D011134:Polysaccharides
keywords: Carbohydrate detection; Fluorescent labelling; Fluorescent polymer; Fluorescently labelled glycolipid; Fluorogenic glycoside; Glycan; Glyconanoparticle; Lectin