title: Prognostic role of genetic biomarkers in clinical progression of prostate cancer.
abstract: The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as well as perform a genetic classification of high-risk patients. A cohort of 451 men (235 patients and 216 controls) was studied. We calculated means of regression analysis using clinical values (stage, prostate-specific antigen, Gleason score and progression) in patients and controls at the basal stage and after a follow-up of 72 months. Significantly different allele frequencies between patients and controls were observed for rs1904577 and rs918 (MSR1 gene) and for rs17552022 and rs5030739 (ELAC2). We found evidence of increased risk for PCa in rs486907 and rs2127565 in variants AA and CC, respectively. In addition, rs627928 (TT-GT), rs486907 (AG) and rs3747531 (CG-CC) were associated with low tumor aggressiveness. Some had a weak linkage, such as rs1904577 and rs2127565, rs4792311 and rs17552022, and rs1904577 and rs918. Our study provides the proof-of-principle that some of the genetic variants (such as rs486907, rs627928 and rs2127565) in genes RNASEL, MSR1 and ELAC2 can be used as predictors of aggressiveness and progression of PCa. In the future, clinical use of these biomarkers, in combination with current ones, could potentially reduce the rate of unnecessary biopsies and specific treatments.
authors.affiliation: 1] Laboratory of Genetic Identification, Faculty of Medicine, Legal Medicine and Toxicology Department, University of Granada, Granada, Spain [2] GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain.
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: Alvarez-Cubero
authors.affiliation: GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain.
authors.forename: Luis Javier
authors.initials: LJ
authors.lastname: Martinez-Gonzalez
authors.affiliation: Laboratory of Genetic Identification, Faculty of Medicine, Legal Medicine and Toxicology Department, University of Granada, Granada, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Saiz
authors.affiliation: GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Carmona-Saez
authors.affiliation: Laboratory of Genetic Identification, Faculty of Medicine, Legal Medicine and Toxicology Department, University of Granada, Granada, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Alvarez
authors.affiliation: Service of Urology, University Hospital Virgen de las Nieves, Granada, Spain.
authors.forename: Manrique
authors.initials: M
authors.lastname: Pascual-Geler
authors.affiliation: 1] Laboratory of Genetic Identification, Faculty of Medicine, Legal Medicine and Toxicology Department, University of Granada, Granada, Spain [2] GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Lorente
authors.affiliation: Service of Urology, University Hospital Virgen de las Nieves, Granada, Spain.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Cozar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D018450:Disease Progression; D004722:Endoribonucleases / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011467:Prostate / Q000378:metabolism / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D051117:Scavenger Receptors, Class A / Q000235:genetics*
chemical_list: C421605:ELAC2 protein, human; D005819:Genetic Markers; C495139:MSR1 protein, human; D009363:Neoplasm Proteins; D051117:Scavenger Receptors, Class A; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease