title: Amine α-heteroarylationviaphotoredox catalysis: a homolytic aromatic substitution pathway.
abstract: The direct α-heteroarylation of tertiary amines has been accomplishedviaphotoredox catalysis to generate valuable benzylic amine pharmacophores. A variety of five-and six-membered chloroheteroarenes are shown to function as viable coupling partners for the α-arylation of a diverse range of cyclic and acyclic amines. Evidence is provided for a homolytic aromatic substitution mechanism, in which a catalyticallygenerated α-amino radical undergoes direct addition to an electrophilic chloroarene.
authors.affiliation: Merck Center for Catalysis at Princeton University, Princeton, New Jersey, 08544, USA.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Prier
authors.affiliation: Merck Center for Catalysis at Princeton University, Princeton, New Jersey, 08544, USA.
authors.forename: David W C
authors.initials: DW
authors.lastname: MacMillan