title: [The Relationship of the Degree of Impairment of the Structure and Function of the Liver with its Chronic Illnesses in Children].
abstract: OBJECTIVE
  Our aim was to on the basis of determining the degree of violation of the structure and function of the liver establish their relationships and to assess the dynamics of liver disease in its chronic illnesses in children.
  
  
  METHODS
  With the help of the developed scoring systems were used to assess the degree of liver dysfunction and the degree of disruption of the structure of the liver and the severity of portal hypertension.
  
  
  RESULTS
  The results of the diagnostic methods 252 children aged 1 to 17 years (mean age of 11.8±3,5) with Wilson disease (WD), autoimmune hepatitis (AIH), chronic hepatitis C (CHC) were analyzed; 48 patients underwent liver transplantation. In children with WD, AIHand CHC liverfunction reduced by 41.3±12.9% to 28.8±12.5% and 19.1±7.8% respectively. Structure of the liver in children with WD, AIH and CHC was disturbed by 25.0±8.1% to 20.4±9.2% and 6.8±4.4% respectively. Thefunction and structure violations of the liver more pronounced in liver cirrhosis. The use of the developed scoring systems to monitor the severity of liver damage in the dynamics and evaluation of the effectiveness of the therapy is demonstrated. The degree of liver dysfunction is directly dependent on the degree of its structure. Abnormal liverfunction ≥40% and ≥40% of its structure with treatment failure can be used as a criterion of indicationsfor elective liver transplantation with its chronic diseases in children.
  
  
  CONCLUSIONS
  Developed a point system to determine liver function and a point system to determine disruption of the structure of the liver and the severity of portal hypertension in children can serve as an objective criterion for assessing the severity of liver disease, monitoring their changes in the dynamics with the assessment of the effectiveness of the therapy and making decisions about the need for routine liver transplantation in its chronic illnesses in children.
authors.forename: G V
authors.initials: GV
authors.lastname: Volynets
authors.forename: N N
authors.initials: NN
authors.lastname: Evliukhina
authors.forename: A V
authors.initials: AV
authors.lastname: Filin
authors.forename: A S
authors.initials: AS
authors.lastname: Potapov
authors.forename: I V
authors.initials: IV
authors.lastname: Dvoriakovskiĭ
authors.forename: G M
authors.initials: GM
authors.lastname: Dvorakovskaia
authors.forename: A N
authors.initials: AN
authors.lastname: Surkov
authors.forename: A A
authors.initials: AA
authors.lastname: Shavrov
authors.forename: N L
authors.initials: NL
authors.lastname: Pakhomovskaia
authors.forename: T A
authors.initials: TA
authors.lastname: Skvortsova
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index