title: Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese: a Case-control Study.
abstract: OBJECTIVE
  To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.
  
  
  METHODS
  A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to describe the strength of the association by logistic regression.
  
  
  RESULTS
  In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P<0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls.
  
  
  CONCLUSIONS
  No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.
authors.affiliation: Department of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi'an 710023, Shannxi, China; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Hai Fei
authors.initials: HF
authors.lastname: You
authors.affiliation: Military Hospital of Henan Province, Zhengzhou 450003, Henan, China.
authors.forename: Jing Zhi
authors.initials: JZ
authors.lastname: Zhao
authors.affiliation: Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China.
authors.forename: Yu Jia
authors.initials: YJ
authors.lastname: Zhai
authors.affiliation: Military Hospital of Henan Province, Zhengzhou 450003, Henan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yin
authors.affiliation: Military Hospital of Henan Province, Zhengzhou 450003, Henan, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Pang
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China.
authors.forename: Xin Ping
authors.initials: XP
authors.lastname: Luo
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan, China.
authors.forename: Jin Jin
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Lin Lin
authors.initials: LL
authors.lastname: Li
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Bing Yuan
authors.initials: BY
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Yong Cheng
authors.initials: YC
authors.lastname: Ren
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China.
authors.forename: Dong Sheng
authors.initials: DS
authors.lastname: Hu
mesh_terms: D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D060492:Low Density Lipoprotein Receptor-Related Protein-5 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012424:Rural Population; D014280:Triglycerides / Q000097:blood
chemical_list: C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D014280:Triglycerides
keywords: Gene polymorphism; Haplotype; Low-density lipoprotein receptor-related protein 5; Metabolic characteristics; Type 2 diabetes mellitus