title: A parietal memory network revealed by multiple MRI methods.
abstract: The manner by which the human brain learns and recognizes stimuli is a matter of ongoing investigation. Through examination of meta-analyses of task-based functional MRI and resting state functional connectivity MRI, we identified a novel network strongly related to learning and memory. Activity within this network at encoding predicts subsequent item memory, and at retrieval differs for recognized and unrecognized items. The direction of activity flips as a function of recent history: from deactivation for novel stimuli to activation for stimuli that are familiar due to recent exposure. We term this network the 'parietal memory network' (PMN) to reflect its broad involvement in human memory processing. We provide a preliminary framework for understanding the key functional properties of the network.
authors.affiliation: Department of Psychology, Washington University in St Louis, St Louis, MO, USA.
authors.forename: Adrian W
authors.initials: AW
authors.lastname: Gilmore
authors.affiliation: VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Nelson
authors.affiliation: Department of Psychology, Washington University in St Louis, St Louis, MO, USA; Department of Radiology, Washington University in St Louis, St Louis, MO, USA. Electronic address: kathleen.mcdermott@wustl.edu.
authors.forename: Kathleen B
authors.initials: KB
authors.lastname: McDermott
mesh_terms: D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008568:Memory / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D010296:Parietal Lobe / Q000033:anatomy & histology* / Q000502:physiology*
keywords: encoding; familiarity; functional networks; memory; parietal cortex; retrieval