title: Aberrant serum polyunsaturated fatty acids profile is relevant with acute coronary syndrome.
abstract: Although a robust relationship between aberrant serum polyunsaturated fatty acids (PUFAs) profile and coronary artery disease (CAD) has been reported, the details concerning the association between aberrant PUFAs profile and clinical feature of CAD are not fully discovered. Therefore, we investigated the relationship between serum PUFAs and clinical profiles in CAD patients. We classified 595 consecutive CAD patients, who underwent coronary angiography into 3 groups according to the clinical profiles of CAD (group A: early phase ACS, n = 96; group B: stable CAD with previous history of ACS, n = 259; group C: stable CAD without previous history of ACS, n = 240) and measured serum n-3 [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)] and n-6 [arachidonic acid (AA)] PUFAs. Serum EPA, DHA, and EPA/AA ratio were significantly low in the order of group A < B < C [EPA; 48.1 (34.1-60.3) μg/ml, 61.7 (41.2-94.5) μg/ml, and 74.4 (52.7-104.9) μg/ml, DHA; 113.1 (92.8-135.1) μg/ml, 125.8 (100.4-167.2) μg/ml, and 140.1 (114.7-177.0) μg/ml, EPA/AA ratio; 0.31 (0.22-0.45), 0.39 (0.26-0.62), and 0.44 (0.31-0.69), medians with interquartile range, p < 0.01]. Multiple regression analysis revealed that EPA (p = 0.009) and EPA/AA ratio (p = 0.023), but not DHA and DHA/AA ratio, were negatively associated with clinical profiles of ACS in CAD patients. Significant correlation was not observed between PUFAs profile and severity of coronary stenosis. Low serum EPA and EPA/AA ratio correlates with clinical profiles of ACS in patients with CAD, regardless of the extent and severity of coronary artery stenosis.
authors.affiliation: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine; 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.|Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sakamoto
authors.affiliation: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine; 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan. msaotome@hama-med.ac.jp.
authors.forename: Masao
authors.initials: M
authors.lastname: Saotome
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Hosoya
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Kageyama
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yoshizaki
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Takeuchi
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Murata
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Nawada
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Onodera
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Takizawa
authors.affiliation: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine; 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Satoh
authors.affiliation: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine; 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D016718:Arachidonic Acid / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000145:classification / Q000000981:diagnostic imaging*; D004281:Docosahexaenoic Acids / Q000097:blood*; D015118:Eicosapentaenoic Acid / Q000097:blood*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid
keywords: Acute coronary syndrome; Arachidonic acid; Coronary artery disease; Docosahexaenoic acid; Eicosapentaenoic acid; n-3 polyunsaturated fatty acid; n-6 polyunsaturated fatty acid