Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats.
OBJECTIVE
The aim of this study was to evaluate the bilirubin lowering and wound healing property of aqueous extract of Calotropis procera (AECP) leaves in Wistar rats.


METHODS
Albino Wistar rats of either sex were used for the study. Bilirubin lowering property of C. procera leaves was evaluated using phenylhydrazine and paracetamol as inducing agents followed by measuring the concentration of serum total bilirubin in hyperbilirubinemic rats. Wound healing property was evaluated using incision and excision models by measuring tensile breaking strength, percentage wound contractions, and epithelization days, respectively.


METHODS
Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.


RESULTS
AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.


CONCLUSIONS
AECP showed significant bilirubin lowering and wound healing property in Wistar rats.
Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India.
Rupali Arun
RA
Patil
Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India.
Aakash B
AB
Makwana
D000082:Acetaminophen / Q000008:administration & dosage; D000818:Animals; D001663:Bilirubin / Q000097:blood; D031107:Calotropis / Q000737:chemistry*; D004195:Disease Models, Animal; D005260:Female; D006932:Hyperbilirubinemia / Q000188:drug therapy*; D008297:Male; D010659:Phenylhydrazines / Q000008:administration & dosage; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
D010659:Phenylhydrazines; D010936:Plant Extracts; C030299:phenylhydrazine; D000082:Acetaminophen; D001663:Bilirubin
Calotropis procera; excision; hyperbilirubinemia; incision; paracetamol; phenylhydrazine; wound healing