[Prognostic value of renal resistance index in estimating the progression of chronic kidney disease].
OBJECTIVE
To study a relationship between main renal and intraparenchymal renal arterial resistance indices (RIs) measured by Doppler ultrasonography and clinical and laboratory parameters and to determine their prognostic value in estimating the progression of chronic kidney disease (CKD).


METHODS
The investigation enrolled 53 CKD patients divided into groups: glomerular and interstitial diseases. Glomerular filtration rate (GFR) calculated using the CKD-EPI formula, proteinuria (PU) severity, kidney sizes, renal parenchyma thickness, parenchyma/collecting index, and main and intrarenal vessel RIs were determined at the first hospitalization. The mean follow-up was 14 ± 2.64 months. The rate of GFR decline was estimated at the rehospitalization.


RESULTS
Main renal and intrarenal vessel RIs depend on patient age and pulse pressure. The RIs are associated with GFR and PU in the group of glomerular diseases and with kidney sizes and structure in that of interstitial diseases. The interlobar arterial RI is the most sensitive predictor for worsening renal function with a threshold of 0.65, which is comparable to the prognostic value of PU.


CONCLUSIONS
The main renal and intrarenal vessel RIs may be considered as a predictor for worsening renal function.
Combined Hospital, Department for Presidential Affairs of the Russian Federation, Moscow, Russia.
V E
VE
Gazhonova
M.V. Lomonosov Moscow State University, Moscow, Russia.
A S
AS
Zykova
M.V. Lomonosov Moscow State University, Moscow, Russia.
A A
AA
Chistyakov
E.M. Tareev Clinic of Nephrology and Internal and Occupational Diseases, University Clinical Hospital Three, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
S V
SV
Roshchupkina
E.M. Tareev Clinic of Nephrology and Internal and Occupational Diseases, University Clinical Hospital Three, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
M D
MD
Romanova
Combined Hospital, Department for Presidential Affairs of the Russian Federation, Moscow, Russia; E.M. Tareev Clinic of Nephrology and Internal and Occupational Diseases, University Clinical Hospital Three, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
T N
TN
Krasnova
D000328:Adult; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D012189:Retrospective Studies; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance / Q000502:physiology*