The efficacy of a photolyase-based device on the cancerization field: a clinical and thermographic study.
BACKGROUND
At skin level, a cancerization field (CF) indicates some chronically photoexposed areas in which, besides a primary tumor, histological or biomolecular modifications without clinical signs are present. Active telethermography (ATT) allows us to observe the imaging of a hyperthermic halo (HH) surrounding the tumor . The Authors hypothesize HH as a possible expression of CF.


OBJECTIVE
The aim of this study were to verify whether HHs have the same histological or immunohistochemical characteristics as the CF and, secondly, to evaluate the efficacy of a device containing the enzyme photolyase in modifying thermographic parameters in these area.


METHODS
The study included 30 patients affected by actinic keratosis, evaluated clinically and by ATT at time 0 and after 3, 6 and 9 months.


RESULTS
The ATT showed the presence of HHs in all the patients and, after the treatment, a significant modification of both the extension of these areas and the thermal parameters. In 5 patients for whom, while operated, two other biopsies were performed, respectively on the HH and on a perilesional non-hyperthermic area, in the HH, we detected a p53 and Ki 67 over-expression.


CONCLUSIONS
Our results indicate that ATT could represent a useful paraclinic method in identifying CFs in subjects at risk.
Thermography, San Gallicano Dermatologic Institute for Research and Care, Via Elio Chianesi 53, 00144, Rome, Italy. laino@ifo.it.
Luigi
L
Laino
Radiology, San Gallicano Dermatologic Institute for Research and Care, Via Elio Chianesi 53, 00144, Rome, Italy. fulviaelia@gmail.com.
Fulvia
F
Elia
Radiology, San Gallicano Dermatologic Institute for Research and Care, Via Elio Chianesi 53, 00144, Rome, Italy. flora7712@yahoo.it.
Flora
F
Desiderio
Clinical Dermatology, San Gallicano Dermatologic Institute for Research and Care, Via Elio Chianesi 53, 00144, Rome, Italy. scarabello@ifo.it.
Alessandra
A
Scarabello
Biostatistical Unit, IFO-Regina Elena National Cancer Institute for Research and Care, Via Elio Chianesi 53, 00144, Rome, Italy. sperduti@ifo.it.
Isabella
I
Sperduti
Dermopathology, San Gallicano Dermatologic Institute for Research and Care, Via Elio Chianesi 53, 00144, Rome, Italy. cota@ifo.it.
Carlo
C
Cota
Scientific Director, San Gallicano Dermatologic Institute for Research and Care, Via Elio Chianesi 53, 00144, Rome, Italy. dicarlo@ifo.it.
Aldo
A
DiCarlo
D000368:Aged; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000737:chemistry; D005260:Female; D006801:Humans; D055623:Keratosis, Actinic / Q000175:diagnosis* / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D013817:Thermography / Q000295:instrumentation*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D004255:Deoxyribodipyrimidine Photo-Lyase