The effect of antenatal magnesium sulfate on left ventricular afterload and myocardial function measured using deformation and rotational mechanics imaging.
OBJECTIVE
Assess the effect of antenatal magnesium sulfate (MgSO4) on left ventricular function measured using deformation and rotational mechanics imaging.


METHODS
Infants who received MgSO4 were matched for gestation, birth weight and mode of delivery with controls. Echocardiography was carried out on days 1 and 2 to measure left ventricle longitudinal strain (LV LS), twist, untwist rate, ejection fraction (EF), and systemic vascular resistance (SVR).


RESULTS
Thirty-eight infants with a median gestation and birth weight of 27.1 weeks and 923 g were included. On day 1, the MgSO4 group (n=19) had a lower SVR and higher LV LS, EF, twist and untwist rate than the Control group (n=19) (all P<0.05). There were no differences between the groups on day 2.


CONCLUSIONS
Antenatal MgSO4 administration is associated with a lower SVR and higher myocardial function on day 1 in preterm infants <29 weeks gestation.
Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.
A T
AT
James
Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.|Department of Paediatrics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
J D
JD
Corcoran
Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.
B
B
Hayes
Department of Paediatric Cardiology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.
O
O
Franklin
Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.|Department of Paediatrics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
A
A
El-Khuffash
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D016022:Case-Control Studies; D015331:Cohort Studies; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D005865:Gestational Age; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016014:Linear Models; D016015:Logistic Models; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods; D012016:Reference Values; D014655:Vascular Resistance / Q000187:drug effects*; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
D000305:Adrenal Cortex Hormones; D008278:Magnesium Sulfate