An asymmetric allylic alkylation reaction of 3-alkylidene oxindoles.
An efficient asymmetric allylic alkylation reaction with respect to 3-alkylidene oxindoles and racemic Morita-Baylis-Hillman carbonate has been achieved by using a chiral biscinchona alkaloid catalyst, which delivers the γ-substituted alkylideneoxindoles with a chiral tertiary center in moderate to good yields (up to 92%) and very good enantioselectivities (up to >99% ee).
State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China. xin_li@nankai.edu.cn.
Junjun
J
Feng
Xin
X
Li
Jin-Pei
JP
Cheng