[The effects of CEACAM6 and FOXP3 on tumor infiltrating lymphocytes and prognosis in patients with pancreatic cancer].
OBJECTIVE
To investigate the expressions of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) and forkhead box P3 (FOXP3) on tumor infiltrating lymphocytes and prognosis in patients with pancreatic cancer.


METHODS
The expressions of CEACAM6, FOXP3, CD3, CD8, CD45RO in pancreatic cancer tissues of 40 cases were assessed by immunohistochemistry, and their relationships with clinicopathological features and prognosis were also analyzed.


RESULTS
The strong positive rates of CEACAM6 and FOXP3 in pancreatic cancer tissues were 50% and 60%, respectively. The higher strong positive rate were observed in stage III and IV. High expression of CEACAM6 was negatively correlated with the positive rates of CD8 and CD45RO cells. The strong positive rate of FOXP3 was higher in poorly differentiated pancreatic cancer, and its expression was negatively correlated with the positive rates of CD3, CD8 and CD45RO cells. The patients which had higher expressions of CEACAM6 and FOXP3 had a shorter survival time.


CONCLUSIONS
CEACAM6 and FOXP3 are associated with the malignant degree of pancreatic cancer. The tumor with higher levels of CEACAM6 and FOXP3 shows inhibited T lymphocyte infiltration.
Department of Gastroenterology, Suzhou 215006; Department of Gastroenterology, Changshu Second People's Hospital, Changshu 215500, China.
Ke
K
Zhang
Department of Gastroenterology, Suzhou 215006, China.
Yingying
Y
Liu
Department of Gastroenterology, Suzhou 215006, China.
Chunhui
C
Jin
Department of Pathology, First Affiliated Hospital, Soochow University, Suzhou 215006, China.
Dongmei
D
Gu
Department of Gastroenterology, Suzhou 215006, China.
Tingting
T
Xia
Department of Gastroenterology, Suzhou 215006, China.
Jianxin
J
Ye
D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D017252:CD3 Complex / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D058851:GPI-Linked Proteins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D017493:Leukocyte Common Antigens / Q000378:metabolism; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
D015703:Antigens, CD; D017252:CD3 Complex; D016827:CD8 Antigens; C504117:CEACAM6 protein, human; D015815:Cell Adhesion Molecules; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D058851:GPI-Linked Proteins; D017493:Leukocyte Common Antigens