'Smartening' anticancer therapeutic nanosystems using biomolecules.
To be effective, anticancer agents must induce cell killing in a selective manner, something that is proving difficult to achieve. Drug delivery systems could help to solve problems associated with the lack of selectivity of classical chemotherapeutic agents. However, to realize this, such systems must overcome multiple physiological barriers. For instance, they must evade surveillance by the immune system, attach selectively to target cells, and gain access to their interior. Furthermore, there they must escape endosomal entrapment, and release their cargoes in a controlled manner, without affecting their functionality. Here we review recent efforts aiming at using biomolecules to confer these abilities to bare nanoparticles, to transform them into smart anticancer therapeutic nanosystems.
Synthetic Biology and Smart Therapeutic Systems Group, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), Parque Tecnológico de Andalucía, C/ Severo Ochoa, 35, 29590 Campanillas, Málaga, Spain.
Rebeca
R
Núñez-Lozano
Synthetic Biology and Smart Therapeutic Systems Group, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), Parque Tecnológico de Andalucía, C/ Severo Ochoa, 35, 29590 Campanillas, Málaga, Spain.
Manuel
M
Cano
Synthetic Biology and Smart Therapeutic Systems Group, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), Parque Tecnológico de Andalucía, C/ Severo Ochoa, 35, 29590 Campanillas, Málaga, Spain; Unit for Methodological and Statistical Support, Andalusian Public Foundation for Health and Biomedical Research in Malaga (FIMABIS), Avd. Jorge Luis Borges, 15, 29010 Málaga, Spain.
Belén
B
Pimentel
Synthetic Biology and Smart Therapeutic Systems Group, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), Parque Tecnológico de Andalucía, C/ Severo Ochoa, 35, 29590 Campanillas, Málaga, Spain. Electronic address: gdelacueva@bionand.es.
Guillermo
G
de la Cueva-Méndez
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002463:Cell Membrane Permeability; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage; D036103:Nanotechnology / Q000379:methods*
D000970:Antineoplastic Agents