Association of Primary Biliary Cirrhosis-autoimmune Hepatitis Overlap Syndrome with Immune Thrombocytopenia and Graves' Disease.
A 54-year-old woman suffering from pruritus for five years was diagnosed to have Graves' disease and immune thrombocytopenia (ITP) associated with primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap syndrome, which was confirmed histologically after a prompt recovery in the platelet count number following steroid therapy. The association between PBC-AIH overlap syndrome and ITP has been rarely reported and the additional association with Graves' disease has not yet been reported. An underlying global derangement of autoimmunity or shared genetic susceptibility was suspected.
Division of Hematology, St. Luke's International Hospital, Japan.
Ryosuke
R
Koyamada
Takakazu
T
Higuchi
Ayako
A
Kitada
Tomoko
T
Nakagawa
Takashi
T
Ikeya
Sadamu
S
Okada
Yoshiyuki
Y
Fujita
D015551:Autoimmunity; D005260:Female; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000473:pathology; D013577:Syndrome