Detecting of gastric cancer by Bcl-2 and Ki67.
Gastric cancer is one of the most common malignant tumors and the second leading cause of cancer-related deaths in China. Although there is some progress in diagnose and treatment, the incidence of gastric cancer still keeps up increasing. In this study 40 patients with gastric cancer who underwent surgical operation is detected by immunohistochemistry. The positive rates of Bcl-2 and Ki67 protein expression in gastric cancer tissues were significantly higher than normal gastric mucous tissues. Correlation analysis showed that the expression of Bcl-2 is not correlated with that of Ki67. Positive expression of Bcl-2 or Ki67 did not correlate with age, gender, differentiation, stage and lymph node metastasis. These suggested that combination of Bcl-2 and Ki67 to detect gastric cancer is more effective.
Department of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University Xi'an, China.
Yongli
Y
Zhou
Department of Pathology, The First Affiliated Hospital of Xi'an Medical University Xi'an, China.
Yandong
Y
Li
Department of Pathology, The First Affiliated Hospital of Xi'an Medical University Xi'an, China.
Jianyun
J
Zheng
Department of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University Xi'an, China.
Kaige
K
Liu
School of Nursing of Xi'an Medical University Xi'an, China.
Hongmei
H
Zhang
D005260:Female; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery
C000595707:BCL2 protein, human; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2
Bcl-2; Ki67; gastric cancer; immunohistochemistry