Highly Branched Poly(β-Amino Esters): Synthesis and Application in Gene Delivery.
Highly branched poly(β-amino esters) (HPAEs) are developed via a facile and controllable "A2+B3/B2" strategy successfully. As nonviral gene delivery vectors, the performance of HPAEs is superior to the well-studied linear counterpart as well as the leading commercial reagent Superfect. When combined with minicircle DNA construct, HPAEs can achieve ultrahigh gene transfection efficiency, especially in keratinocytes.
Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin , Belfield, Dublin 4, Ireland.
Lara
L
Cutlar
Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin , Belfield, Dublin 4, Ireland.
Dezhong
D
Zhou
Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin , Belfield, Dublin 4, Ireland.
Yongsheng
Y
Gao
Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin , Belfield, Dublin 4, Ireland.
Tianyu
T
Zhao
Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin , Belfield, Dublin 4, Ireland.
Udo
U
Greiser
Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin , Belfield, Dublin 4, Ireland.|School of Materials Science and Engineering, Tianjin University , Tianjin 300072, China.
Wei
W
Wang
Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin , Belfield, Dublin 4, Ireland.|School of Materials Science and Engineering, Tianjin University , Tianjin 300072, China.
Wenxin
W
Wang
D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000737:chemistry*; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry
D004952:Esters; D011073:Polyamines; D004247:DNA