[SPIRULINA AND ITS HYPOLIPIDEMIC AND ANTIOXIDANT EFFECTS IN HUMANS: A SYSTEMATIC REVIEW].
Several chronic transmissible (e.g. AIDS) and non transmissible diseases like cadiovascular disease, are associated with oxidative stress (EOX) and dyslipidemia. Has been reported that Spirulina can reduce them, this has been demonstrated in vitro and in animal models but scarcely in humans. Through a systematic review on last 5 years (keywords: Spirulina AND cholesterol, Spirulina AND oxidative stress) 8 intervention studies with humans were reported, finding that oral (1-10 g/d) subchronic (0.5-6 month) administration of Spirulina appears to have and hypolipidemic and antioxidant effect. However, no study was properly randomized and/or controlled and no biological mechanism was proposed to support these findings. The level of evidence and the absence of appropriate experimental designs do not allow validating Spirulina as a functional food for preventing dyslipidemic diseases and EOX, and hereby decrease the CVD. We do not found papers relating harmful effect.
Departamento de Ciencias de la Salud, Instituto de Ciencias Biomédicas. Universidad Autónoma de Ciudad Juárez, Ciudad Juárez (Chihuahua).. qblepe@hotmail.com.
Marco Antonio
MA
Hernández Lepe
Departamento de Ciencias de la Salud, Instituto de Ciencias Biomédicas. Universidad Autónoma de Ciudad Juárez, Ciudad Juárez (Chihuahua).. awall@uacj.mx.
Abraham
A
Wall-Medrano
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, México D. F.. majo_ya@yahoo.com.mx.
Marco Antonio
MA
Juárez-Oropeza
Departamento de Ciencias de la Salud, Instituto de Ciencias Biomédicas. Universidad Autónoma de Ciudad Juárez, Ciudad Juárez (Chihuahua).. aramos@uacj.mx.
Arnulfo
A
Ramos-Jiménez
Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Chihuahua (México).. aramos@uacj.mx.
Rosa P
RP
Hernández-Torres
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D050171:Dyslipidemias / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D053545:Spirulina / Q000737:chemistry*
D000975:Antioxidants; D000960:Hypolipidemic Agents