Two new cassane-type diterpenes from the seeds of Caesalpinia crista.
Two new cassane-type diterpenes, phangininoxys D and E (1 and 2), together with five known compounds were isolated from the seeds of Caesalpinia crista Linn. The structures of these compounds were elucidated by means of various spectroscopic analyses. All the isolated compounds were evaluated for cytotoxicity activities against HeLa, HT-29 and KB cell lines, and compound 7 showed moderate selective activities against KB cell line with an IC50 value of 17.1 μM.
a Department of Pharmacology , School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
Qi-Bing
QB
Liu
a Department of Pharmacology , School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
Ling
L
Huang
a Department of Pharmacology , School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
Li
L
Zhang
a Department of Pharmacology , School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
Qiang
Q
Liu
a Department of Pharmacology , School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
Qiao-Qin
QQ
Xu
a Department of Pharmacology , School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
Xian-Jing
XJ
Qin
a Department of Pharmacology , School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
Xing-Yue
XY
Fang
a Department of Pharmacology , School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
Yu
Y
Zeng
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029911:Caesalpinia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C000605472:phangininoxy D; C000605473:phangininoxy E
Caesalpinia crista; Fabaceae; cassane-type diterpenes; cytotoxic activities