DEVELOPMENT OF EPSTEIN-BARR VIRUS UVEITIS AFTER REMISSION OF PRIMARY VITREORETINAL LYMPHOMA.
OBJECTIVE
To describe a case of Epstein-Barr virus (EBV) uveitis that occurred after the treatment and remission of primary vitreoretinal lymphoma (PVRL).


METHODS
Descriptive case report. Complete ophthalmologic evaluation, cytology, polymerase chain reaction, cytokine analysis of aqueous humor, and diagnostic vitrectomy were performed.


RESULTS
A 66-year-old Caucasian woman developed uveitis in the same eye 20 months after remission of PVRL. Empiric chemotherapy failed to treat the suspected PVRL recurrence, and aqueous humor cytology showed an absence of malignant cells. Qualitative polymerase chain reaction of aqueous humor confirmed the presence of EBV. Treatment for EBV resulted in remission of the uveitis.


CONCLUSIONS
The authors describe a rare case of EBV uveitis that was preceded by PVRL. It is important to consider EBV in cases where suspected recurrence of PVRL does not respond to appropriate treatment.
Department of Ophthalmology, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Barinder S
BS
Chahal
Steve
S
Rasmussen
Valerie A
VA
White
Farzin
F
Forooghian
D000368:Aged; D001082:Aqueous Humor / Q000000981:diagnostic imaging / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D015828:Eye Infections, Viral / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008223:Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D016133:Polymerase Chain Reaction; D019572:Retinal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology*
D004279:DNA, Viral