Two-stage autotransplantation of human submandibular gland: a novel approach to treat postradiogenic xerostomia.
Xerostomia is a persistent side effect of radiotherapy (RT), which severely reduces the quality of life of the patients affected. Besides drug treatment and new irradiation strategies, surgical procedures aim for tissue protection of the submandibular gland. Using a new surgical approach, the submandibular gland was autotransplanted in 6 patients to the patient's forearm for the period of RT and reimplanted into the floor of the mouth 2-3 months after completion of RT. Saxon's test was performed during different time points to evaluate patient's saliva production. Furthermore patients had to answer EORTC QLQ-HN35 questionnaire and visual analog scale. Following this two-stage autotransplantation, xerostomia in the patients was markedly reduced due to improved saliva production of the reimplanted gland. Whether this promising novel approach is a reliable treatment option for RT patients in general should be evaluated in further studies.
University Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, Josef-Schneider Str. 11, 97080, Würzburg, Germany. Hagen_R@ukw.de.
Rudolf
R
Hagen
University Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, Josef-Schneider Str. 11, 97080, Würzburg, Germany.
Matthias
M
Scheich
University Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, Josef-Schneider Str. 11, 97080, Würzburg, Germany.
Norbert
N
Kleinsasser
Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum Stuttgart, Stuttgart, Germany.
Marc
M
Burghartz
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D005240:Feasibility Studies; D005542:Forearm; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000532:radiotherapy; D007822:Laryngeal Neoplasms / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy; D011446:Prospective Studies; D011788:Quality of Life; D011832:Radiation Injuries / Q000517:prevention & control; D012092:Replantation; D013363:Submandibular Gland / Q000502:physiology / Q000601:surgery* / Q000637:transplantation*; D011795:Surveys and Questionnaires; D013997:Time Factors; D014182:Transplantation, Autologous; D014987:Xerostomia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control / Q000601:surgery*
Autotransplantation; Postradiogenic xerostomia; Submandibular gland