The Systemic Control of Growth.
Growth is a complex process that is intimately linked to the developmental program to form adults with proper size and proportions. Genetics is an important determinant of growth, as exemplified by the role of local diffusible molecules setting up organ proportions. In addition, organisms use adaptive responses allowing modulating the size of individuals according to environmental cues, for example, nutrition. Here, we describe some of the physiological principles participating in the determination of final individual size.
University of Nice-Sophia Antipolis, 06108 Nice, France CNRS, University of Nice-Sophia Antipolis, 06108 Nice, France INSERM, University of Nice-Sophia Antipolis, 06108 Nice, France.
Laura
L
Boulan
5ICREA, Parc Cientific de Barcelona, 08028 Barcelona, Spain.
Marco
M
Milán
University of Nice-Sophia Antipolis, 06108 Nice, France CNRS, University of Nice-Sophia Antipolis, 06108 Nice, France INSERM, University of Nice-Sophia Antipolis, 06108 Nice, France.
Pierre
P
Léopold
D000818:Animals; D049628:Body Size; D004330:Drosophila / Q000033:anatomy & histology / Q000235:genetics / Q000254:growth & development*; D006128:Growth / Q000235:genetics*; D013006:Growth Hormone / Q000378:metabolism / Q000502:physiology; D007328:Insulin / Q000378:metabolism / Q000502:physiology; D008675:Metamorphosis, Biological; D009747:Nutritional Physiological Phenomena; D015398:Signal Transduction; D013002:Somatomedins / Q000378:metabolism / Q000502:physiology; D013045:Species Specificity
D007328:Insulin; D013002:Somatomedins; D013006:Growth Hormone