Canine model of crush syndrome established by a digital crush injury device platform.
OBJECTIVE
To establish a canine model of crush syndrome (CS).


METHODS
A total of 16 healthy adult female Beagle dogs were randomly divided into the control group (n=8) and the experimental group (n=8). The crush injury was created in the left hind leg of each dog in the experimental group.


RESULTS
The biochemical indexes in the experimental group changed significantly compared to the values before extrusion. And they were also significantly different from the values of the control group. The glomerular capillary dilation, renal tubular epithelial cell degeneration, and renal interstitial lymphocytic infiltration were found in the kidneys.


CONCLUSIONS
The canine CS model established by the digital crush injury device platform was successful according with the diagnosis of CS. It is good for the investigation of the CS mechanism and treatment using this model.
Tianjin Medical University Tianjin 300162, P. R. China ; Key Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces Tianjin 300162, P. R. China ; Department of Nephrology, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces Tianjin 300162, P. R. China.
Jie
J
Song
Key Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces Tianjin 300162, P. R. China.
Hui
H
Ding
Key Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces Tianjin 300162, P. R. China.
Hao-Jun
HJ
Fan
Key Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces Tianjin 300162, P. R. China.
Wen-Long
WL
Dong
Key Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces Tianjin 300162, P. R. China.
Zhen-Xing
ZX
Sun
Key Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces Tianjin 300162, P. R. China.
Shi-Ke
SK
Hou
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003444:Crush Syndrome / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D004195:Disease Models, Animal; D004285:Dogs; D004867:Equipment Design; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis / Q000209:etiology; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007869:Leg Injuries / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D018482:Muscle, Skeletal / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009212:Myoglobinuria / Q000175:diagnosis / Q000209:etiology; D012206:Rhabdomyolysis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors
D015415:Biomarkers
Crush syndrome; crush injury device platform; dogs