MDA-9/Syntenin Control.
MDA-9/Syntenin is a small PDZ domain containing scaffolding protein with diverse array of functions regulating membrane trafficking, cell adhesion, neural, and synaptic development, ubiquitination, and exosome biogenesis. An appreciable number of studies also established a pivotal role of MDA-9/Syntenin in cancer development and progression. In this review, we will discuss the dynamic role of MDA-9/Syntenin in regulating normal and abnormal fate of various cellular processes.
Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Julie V
JV
Philley
Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Anbarasu
A
Kannan
Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Santanu
S
Dasgupta
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D053676:Syntenins / Q000378:metabolism*
C109621:SDCBP protein, human; D053676:Syntenins