Novel roles and therapeutic targets of Epstein-Barr virus-encoded latent membrane protein 1-induced oncogenesis in nasopharyngeal carcinoma.
Epstein-Barr virus (EBV) was first discovered 50 years ago as an oncogenic gamma-1 herpesvirus and infects more than 90% of the worldwide adult population. Nasopharyngeal carcinoma (NPC) poses a serious health problem in southern China and is one of the most common cancers among the Chinese. There is now strong evidence supporting a role for EBV in the pathogenesis of NPC. Latent membrane protein 1 (LMP1), a primary oncoprotein encoded by EBV, alters several functional and oncogenic properties, including transformation, cell death and survival in epithelial cells in NPC. LMP1 may increase protein modification, such as phosphorylation, and initiate aberrant signalling via derailed activation of host adaptor molecules and transcription factors. Here, we summarise the novel features of different domains of LMP1 and several new LMP1-mediated signalling pathways in NPC. When then focus on the potential roles of LMP1 in cancer stem cells, metabolism reprogramming, epigenetic modifications and therapy strategies in NPC.
Cancer Research Institute,Central South University,Changsha,Hunan 410078,China.
Yongguang
Y
Tao
Cancer Research Institute,Central South University,Changsha,Hunan 410078,China.
Ying
Y
Shi
Cancer Research Institute,Central South University,Changsha,Hunan 410078,China.
Jiantao
J
Jia
Cancer Research Institute,Central South University,Changsha,Hunan 410078,China.
Yiqun
Y
Jiang
Cancer Research Institute,Central South University,Changsha,Hunan 410078,China.
Lifang
L
Yang
Cancer Research Institute,Central South University,Changsha,Hunan 410078,China.
Ya
Y
Cao
D002277:Carcinoma; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000472:pathogenicity; D054884:Host-Pathogen Interactions; D006801:Humans; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology / Q000821:virology; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D014763:Viral Matrix Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D016159:Tumor Suppressor Protein p53; D014763:Viral Matrix Proteins; C512478:EGFR protein, human; D066246:ErbB Receptors