Probing the Nature of Charge Transfer at Nano-Bio Interfaces: Peptides on Metal Oxide Nanoparticles.
Characterizing the nano-bio interface has been a long-standing endeavor in the quest for novel biosensors, biophotovoltaics, and biocompatible electronic devices. In this context, the present computational work on the interaction of two peptides, A6K (Ac-AAAAAAK-NH2) and A7 (Ac-AAAAAAA-NH2) with semiconducting TiO2 nanoparticles is an effort to understand the peptide-metal oxide nanointerface. These investigations were spurred by recent experimental observations that nanostructured semiconducting metal oxides templated with A6K peptides not only stabilize large proteins like photosystem-I (PS-I) but also exhibit enhanced charge-transfer characteristics. Our results indicate that α-helical structures of A6K are not only energetically more stabilized on TiO2 nanoparticles, but the resulting hybrids also exhibit enhanced electron transfer characteristics. This enhancement can be attributed to substantial changes in the electronic characteristics at the peptide-TiO2 interface. Apart from understanding the mechanism of electron transfer (ET) in peptide-stabilized PS-I on metal oxide nanoparticles, the current work also has implications in the development of novel solar cells and photocatalysts.
†Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, United States.
Pilarisetty
P
Tarakeshwar
‡Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-5001, United States.
Julio L
JL
Palma
§Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, California 92182-1030, United States.
Gregory P
GP
Holland
†Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, United States.
Petra
P
Fromme
†Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, United States.
Jeffery L
JL
Yarger
†Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, United States.
Vladimiro
V
Mujica
DFT calculations; biophotovoltaics; charge-transfer; devices; semiconducting nanomaterials; sensors