[Immunohistochemical evaluation of mutant p53 protein over-expression in non-mucinous adenocarcinoma in-situ and invasive adenocarcinoma, NOS of lung].
OBJECTIVE
To study the over-expression of mutant p53 protein in non-mucinous adenocarcinoma in-situ (NMAIS) and invasive adenocarcinoma, NOS of lung.


METHODS
Immunohistochemical study for p53 protein was performed on 17 cases of NMAIS and 70 cases of invasive adenocarcinoma, NOS of lung. The difference in p53 over-expression between the two tumor subtypes was analyzed.


RESULTS
The over-expression of mutant p53 protein was observed in 0 case (0%) of NMAIS and 37 cases (52.9%) of invasive adenocarcinoma, NOS of lung. The difference was of statistical significance (P = 0.000).


CONCLUSIONS
Mutant p53 protein over-expression may play a role in the progression of NMAIS to invasive adenocarcinoma, NOS.
Yayan
Y
Cui
Jie
J
Zhang
Jiping
J
Da
Honglei
H
Zhang
Dong
D
Chen
D000230:Adenocarcinoma / Q000378:metabolism*; D065311:Adenocarcinoma in Situ / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D050505:Mutant Proteins / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D050505:Mutant Proteins; D016159:Tumor Suppressor Protein p53