Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-α Inhibitor Treatment: Management and Control.
We describe a large outbreak associated with a crusted (Norwegian) scabies case in an immunocompromised patient following treatment with TNF-α inhibitor (adalimumab) for psoriasis arthritis. The increasing use of TNF-α inhibitors should induce clinicians to consider this serious parasitic infection when evaluating skin rashes in patients receiving biologic therapies.
1UOC Malattie Infettive,Ospedale SM Goretti,Università Sapienza,Latina,Italy.
Valeria
V
Belvisi
2Dipartimento di Sanità Pubblica e Malattie Infettive,Sapienza Università di Roma,Italy.
Giovanni Battista
GB
Orsi
1UOC Malattie Infettive,Ospedale SM Goretti,Università Sapienza,Latina,Italy.
Cosmo
C
Del Borgo
1UOC Malattie Infettive,Ospedale SM Goretti,Università Sapienza,Latina,Italy.
Paolo
P
Fabietti
3UOC Rischio Clinico,ASL,Latina,Italy.
Adriana
A
Ianari
4UOC Epidemiologia,ASL,Latina,Italy.
Francesco
F
Albertoni
5UOS Malattie Infettive e Prevenzione,ASL Latina,Italy.
Patricia
P
Porcelli
6UOC Dermatologia,Università Sapienza,Terracina,Italy.
Concetta
C
Potenza
1UOC Malattie Infettive,Ospedale SM Goretti,Università Sapienza,Latina,Italy.
Claudio Maria
CM
Mastroianni
D000068879:Adalimumab / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D015535:Arthritis, Psoriatic / Q000188:drug therapy; D003428:Cross Infection / Q000453:epidemiology*; D004196:Disease Outbreaks; D005260:Female; D006761:Hospitals; D006801:Humans; D016867:Immunocompromised Host; D007558:Italy; D012532:Scabies / Q000453:epidemiology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D014409:Tumor Necrosis Factor-alpha; D000068879:Adalimumab