Non-progressive cerebellar ataxia and previous undetermined acute cerebellar injury: a mysterious clinical condition.
Cerebellar ataxias represent a wide group of neurological diseases secondary to dysfunctions of cerebellum or its associated pathways, rarely coursing with acute-onset acquired etiologies and chronic non-progressive presentation. We evaluated patients with acquired non-progressive cerebellar ataxia that presented previous acute or subacute onset. Clinical and neuroimaging characterization of adult patients with acquired non-progressive ataxia were performed. Five patients were identified with the phenotype of acquired non-progressive ataxia. Most patients presented with a juvenile to adult-onset acute to subacute appendicular and truncal cerebellar ataxia with mild to moderate cerebellar or olivopontocerebellar atrophy. Establishing the etiology of the acute triggering events of such ataxias is complex. Non-progressive ataxia in adults must be distinguished from hereditary ataxias.
Departamento de Neurologia e Neurocirurgia, Divisão de Neurologia Geral e Unidade de Ataxia, Universidade Federal de São Paulo, Sao Paulo, SP, BR.
Wladimir Bocca Vieira de Rezende
WB
Pinto
Departamento de Neurologia e Neurocirurgia, Divisão de Neurologia Geral e Unidade de Ataxia, Universidade Federal de São Paulo, Sao Paulo, SP, BR.
José Luiz
JL
Pedroso
Departamento de Neurologia e Neurocirurgia, Divisão de Neurologia Geral e Unidade de Ataxia, Universidade Federal de São Paulo, Sao Paulo, SP, BR.
Paulo Victor Sgobbi de
PV
Souza
Departamento de Neurologia e Neurocirurgia, Divisão de Neurologia Geral e Unidade de Ataxia, Universidade Federal de São Paulo, Sao Paulo, SP, BR.
Marcus Vinícius Cristino de
MV
Albuquerque
Departamento de Neurologia e Neurocirurgia, Divisão de Neurologia Geral e Unidade de Ataxia, Universidade Federal de São Paulo, Sao Paulo, SP, BR.
Orlando Graziani Povoas
OG
Barsottini
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002524:Cerebellar Ataxia / Q000175:diagnosis / Q000209:etiology*; D002526:Cerebellar Diseases / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D035583:Rare Diseases; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013577:Syndrome