Mandible ameloblastoma with lung metastasis: a rare case report.
BACKGROUND
The ameloblastoma is the most common odontogenic epithelial tumor, which belong to benign neoplasms that present a painless course, and usually occur in the oromaxillo-facial region. Although the histopathological manifestation of ameloblastoma is benign, it has unique biological behavior, for example local invasion and recurrence repeatedly. A few case of ameloblastoma was locally aggressive growth, and rarely metastasis to other tissue, for example the lungs, lymph nodes, and spine.


METHODS
A 64-year-old Chinese man, diagnosed with metastatic ameloblastoma, was treated with palliative chemotherapy consisting of cyclophosphamide, doxorubicin, and cisplatin for six cycles, and radiotherapy for 50 Gy after the last cycle chemotherapy. During the surveillance CT scan after the therapy, the tissues of the tumor were nearly complete response.


CONCLUSIONS
The purpose of this study was to report a case of a patient with a right mandible ameloblastoma that recurred repeatedly and metastasized into bilateral lung. After the chemotherapy and radiotherapy, the tissues of the tumor were nearly complete response. This case is interesting because it investigated the diagnosis and treatment of the malignancy ameloblastoma, as this may help diagnose and treatment for clinician to the metastatic ameloblastoma.
Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Rui-Na
RN
Yang
Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Xin-Shuai
XS
Wang
Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Jing
J
Ren
Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Yan-Fei
YF
Xie
Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Dan
D
Zhou
Departments of Pathology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Dong-Feng
DF
Ge
Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Xiao-Shan
XS
Feng
Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
She-Gan
SG
Gao
D000564:Ameloblastoma / Q000737:chemistry / Q000556:secondary* / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000627:therapeutic use; D016371:Cranial Irradiation; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D008297:Male; D008339:Mandibular Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010166:Palliative Care; D011879:Radiotherapy Dosage; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin
Ameloblastoma; chemotherapy; mandible; metastasis