Enteric-type adenocarcinoma of the lung harbouring a novel KRAS Q22K mutation with concomitant KRAS polysomy: a case report.
This case describes a novel KRAS Q22K mutation with simultaneous KRAS polysomy in a patient with advanced, enteric-type, adenocarcinoma of the lung. Despite the administration of systemic chemotherapy, the disease underwent rapid progression and led to the patient's death in a short period of time. Such an aggressive clinical course suggests that, in this specific case, KRAS dependency was the major genetic driver of poor prognosis. Direct deoxy ribonucleic acid (DNA) sequencing of the KRAS gene allows for the detection of novel KRAS mutations, and it might be advocated in patients with advanced non-small cell lung cancer in view of the emerging role of KRAS as a potential therapeutic target.
Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia 06156, Italy.
Giulio
G
Metro
Niguarda Cancer Center, Division of Pathology, Ospedale Niguarda Ca' Granda, Milano 20162, Italy.
Emanuele
E
Valtorta
Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia 06156, Italy.
Annamaria
A
Siggillino
Niguarda Cancer Center, Division of Pathology, Ospedale Niguarda Ca' Granda, Milano 20162, Italy.
Calogero
C
Lauricella
Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia 06156, Italy.
Matteo
M
Cenci
Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia 06156, Italy.
Vienna
V
Ludovini
Medical Oncology, Santa Maria Hospital, Azienda Ospedaliera di Terni, Terni 05100, Italy.
Elisa
E
Minenza
Department of Experimental Medicine, Pathological Anatomy and Histology Unit, School of Medicine, University of Perugia, Perugia 06156, Italy.
Enrico
E
Prosperi
Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia 06156, Italy.
Biagio
B
Ricciuti
Department of Diagnostic Imaging, Santa Maria della Misericordia Hospital, University of Perugia 06156, Italy.
Alberto
A
Rebonato
Medical Oncology, Narni Hospital, Narni (TR) 05035, Italy.
Alessandra
A
Bassetti
Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia 06156, Italy.
Lucio
L
Crinò
DNA sequencing; KRAS; enteric-type adenocarcinoma; gene mutation; non-small cell lung cancer