The association of the platelet-to-lymphocyte ratio with mitral annular calcification.
OBJECTIVE
Mitral annular calcification (MAC) and atherosclerosis are similar in regard to risk factors and pathogenesis. Increased platelet-to-lymphocyte ratio (PLR) has been shown to be associated with atherosclerotic diseases in previous studies. In this study, we aimed to show the association of PLR levels with the presence of MAC.


METHODS
A total of 1060 patients [n = 704 MAC (+), and n = 356 MAC (-)] who were admitted to our cardiology department were enrolled between January 2014 and December 2014. Demographic, clinical, and laboratory parameters of all participants were recorded. PLR was calculated from the complete blood count.


RESULTS
The MAC (+) group comprised of those older in age and having a higher rate of hypertension. The mean PLR value was also significantly higher in the MAC (+) group, as compared to that in the MAC (-) group (129.1 ± 32.2 vs 103.5 ± 23.8, p < 0.001). There was a statistically significant and positive correlation between the neutrophil-to-lymphocyte ratio (NLR) and PLR (r = 0.644, p < 0.001). Age, hypertension, mean platelet volume, NLR, and PLR (OR: 1.109, 95% CI: 1.101-1.123, p < 0.001) were independently associated with the presence of MAC.


CONCLUSIONS
Our results demonstrated that the PLR was significantly increased in patients with MAC, and that the PLR was independently associated with the presence of MAC.
a Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
Çağri
Ç
Yayla
a Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
Mehmet Kadri
MK
Akboga
a Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
Ugur
U
Canpolat
b Dışkapı Yıldırım Beyazıt Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
Kadriye
K
Gayretli Yayla
a Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
Mevlut Serdar
MS
Kuyumcu
a Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
Fatih
F
Bayraktar
a Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
Muhammed
M
Suleymanoglu
a Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
Sinan
S
Aydogdu
D000367:Age Factors; D000368:Aged; D001792:Blood Platelets; D002114:Calcinosis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D016015:Logistic Models; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D015999:Multivariate Analysis; D016017:Odds Ratio; D010976:Platelet Count; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D014463:Ultrasonography
inflammation; mitral annular calcification; platelet-to-lymphocyte ratio