The genomic landscape of human immune-mediated diseases.
As the methodology of genetic detection has developed rapidly in recent years, through techniques such as genome-wide association studies (GWAS) and the secondary generation of sequencing, we are able to view the genomic landscape more clearly. It is well known that genes have a vital role in the pathogenesis of immune-mediated diseases (IMDs), which could provide important insight into new clinical therapeutic targets. Here, we review the genomic landscape of IMDs and analyse overlapping loci between diseases. There may be a need for more epigenetics studies to aid in the understanding of the transition from genotype to phenotype.
Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China.
Xin
X
Wu
Department of Rheumatology, Zhongda Hospital, Southeast University, Shanghai, China.
Haiyan
H
Chen
Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China.
Huji
H
Xu
D000483:Alleles; D044127:Epigenesis, Genetic; D005006:Ethnicity / Q000235:genetics; D056726:Genetic Association Studies; D055106:Genome-Wide Association Study; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics*; D053765:Interleukin-12 Subunit p35 / Q000235:genetics; D008285:Major Histocompatibility Complex; D058504:Th17 Cells / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
C508858:IL12A protein, human; D053765:Interleukin-12 Subunit p35; D014409:Tumor Necrosis Factor-alpha