The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Noriyuki
N
Fuku
European University of Madrid, Madrid, Spain.|Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
Helios
H
Pareja-Galeano
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Hirofumi
H
Zempo
Research Institute 'Dr. Viña Giner', Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.|School of Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.
Rafael
R
Alis
Center for Supercentenarian Study, Keio University School of Medicine, Tokyo, Japan.
Yasumichi
Y
Arai
European University of Madrid, Madrid, Spain.|Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
Alejandro
A
Lucia
Center for Supercentenarian Study, Keio University School of Medicine, Tokyo, Japan.
Nobuyoshi
N
Hirose
D000375:Aging / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D007564:Japan; D008136:Longevity / Q000235:genetics*; D008928:Mitochondria / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics; D010455:Peptides / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics*
D004272:DNA, Mitochondrial; D010455:Peptides; D012335:RNA, Ribosomal; C075526:RNA, ribosomal, 12S
aging; centenarians; longevity gene; longevity regulation; mitochondria; mitochondrial DNA; mitochondrial DNA abnormalities; molecular biology of aging