[Effects of hemoperfusion treatment on serum IL-23 and IL-17 levels in children with Henoch-Schönlein purpure].
OBJECTIVE
To study the effects of hemoperfusion treatment on serum interleukin-17 (IL-17) and IL-23 levels in children with Henoch-Schönlein purpura (HSP).


METHODS
Eighty-seven children who were diagnosed with HSP and who had received hemoperfusion treatment between January 2011 and December 2012 were enrolled. Twenty-seven sex- and age-matched healthy children were recruited as normal controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of IL-17 and IL-23.


RESULTS
The serum IL-23 and IL-17 levels in the HSP group were significantly higher than in the control group (P<0.05). After hemoperfusion treatment, the serum IL-23 and IL-17 levels in the HSP group were significantly reduced to the levels of the control group. Serum serum IL-17 level was positively correlated with serum IL-23 level (P<0.05) in children with HSP.


CONCLUSIONS
Hemoperfusion treatment can reduce serum IL-23 and IL-17 levels in children with HSP, suggesting that the treatment may be effective for HSP.
Department of Pediatrics, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. haungyp423@126.com.
Li
L
Liu
Yan-Ping
YP
Huang
Xia-Ling
XL
Fang
Yuan-Yuan
YY
Zhang
Ning
N
Chen
Hong-Hong
HH
Hou
D002648:Child; D002675:Child, Preschool; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology / Q000628:therapy*; D020381:Interleukin-17 / Q000097:blood* / Q000502:physiology; D053759:Interleukin-23 / Q000097:blood* / Q000502:physiology; D008297:Male
D020381:Interleukin-17; D053759:Interleukin-23