Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China.
The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups. We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits. We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample. Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG. We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample. Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations.
Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China.
Haihua
H
Bai
Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China.
Haiping
H
Liu
Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China.
Suyalatu
S
Suyalatu
BGI-Shenzhen, Shenzhen 518083, China ; Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.
Xiaosen
X
Guo
Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China.
Shandan
S
Chu
BGI-Shenzhen, Shenzhen 518083, China.
Ying
Y
Chen
BGI-Shenzhen, Shenzhen 518083, China.
Tianming
T
Lan
Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China.
Burenbatu
B
Borjigin
The Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia ; Novosibirsk State University, Novosibirsk 630090, Russia.
Yuriy L
YL
Orlov
The Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia ; Novosibirsk State University, Novosibirsk 630090, Russia.
Olga L
OL
Posukh
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Xiuqin
X
Yang
Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China.
Guilan
G
Guilan
The Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia.
Ludmila P
LP
Osipova
Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China.
Qizhu
Q
Wu
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Narisu
N
Narisu
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D015992:Body Mass Index; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008986:Mongolia; D020641:Polymorphism, Single Nucleotide; D011786:Quality Control; D014280:Triglycerides / Q000097:blood
D005819:Genetic Markers; D014280:Triglycerides