D-penicillamine Induced Degenerative Dermopathy.
D-penicillamine interferes with elastin and collagen metabolism and produces several cutaneous and multi-systemic side-effects. We present two cases of Wilson's disease who on long-term penicillamine therapy developed drug-induced degenerative dermopathy manifesting as skin fragility over pressure sites and cutis laxa-like changes.
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Sujay
S
Khandpur
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Naresh
N
Jain
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Shweta
S
Singla
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Priti
P
Chatterjee
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Madhuri
M
Behari
Degenerative dermopathy; chronic therapy; penicillamine