Does Streptococcus mitis, a neonatal oropharyngeal bacterium, influence the pathogenicity of Pseudomonas aeruginosa?
Microorganisms in a biofilm might promote or suppress each other. We previously found that Pseudomonas aeruginosa (P. aeruginosa) and the normal colonized bacteria in the oropharynx, Streptococcus mitis (S. mitis), were the most common bacteria in the biofilm found on newborns' endotracheal tubes. Here, we found that S. mitis enhanced the adhesion and biofilm formation of P. aeruginosa. Furthermore, it alleviated the immune response induced by P. aeruginosa. These findings remind us that we should not ignore the role of traditionally viewed non-pathogenic bacteria in biofilms and provide new insights into exploring bacterial interaction mechanisms in biofilm related infections.
Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China.
Sijie
S
Song
Department of Pediatrics, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Lizhong
L
Du
Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China. Electronic address: tongxunzuozhe@163.com.
Jialin
J
Yu
Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China.
Qing
Q
Ai
Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China.
Yun
Y
Pan
Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China.
Yakun
Y
Fu
Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China.
Zhengli
Z
Wang
D001422:Bacterial Adhesion; D018441:Biofilms / Q000254:growth & development*; D004864:Equipment and Supplies / Q000382:microbiology; D006801:Humans; D057131:Immune Evasion; D007442:Intubation, Intratracheal; D056265:Microbial Interactions; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity* / Q000502:physiology*; D034361:Streptococcus mitis / Q000502:physiology*
Host bacteria interaction; Newborns; Pseudomonas aeruginosa; Streptococcus mitis; Ventilator associated pneumonia