Influence of menopause and Type 2 diabetes on pulmonary oxygen uptake kinetics and peak exercise performance during cycling.
We investigated if the magnitude of the Type 2 diabetes (T2D)-induced impairments in peak oxygen uptake (V̇O2) and V̇O2 kinetics was affected by menopausal status. Twenty-two women with T2D (8 premenopausal, 14 postmenopausal), and 22 nondiabetic (ND) women (11 premenopausal, 11 postmenopausal) matched by age (range = 30-59 yr) were recruited. Participants completed four bouts of constant-load cycling at 80% of their ventilatory threshold for the determination of V̇O2 kinetics. Cardiac output (CO) (inert gas rebreathing) was recorded at rest and at 30 s and 240 s during two additional bouts. Peak V̇O2 was significantly (P < 0.05) reduced in both groups with T2D compared with ND counterparts (premenopausal, 1.79 ± 0.16 vs. 1.55 ± 0.32 l/min; postmenopausal, 1.60 ± 0.30 vs. 1.45 ± 0.24 l/min). The time constant of phase II of the V̇O2 response was slowed (P < 0.05) in both groups with T2D compared with healthy counterparts (premenopausal, 29.1 ± 11.2 vs. 43.0 ± 12.2 s; postmenopausal, 33.0 ± 9.1 vs. 41.8 ± 17.7 s). At rest and during submaximal exercise absolute CO responses were lower, but the "gains" in CO larger (both P < 0.05) in both groups with T2D. Our results suggest that the magnitude of T2D-induced impairments in peak V̇O2 and V̇O2 kinetics is not affected by menopausal status in participants younger than 60 yr of age.
School of Medicine, Department of Physiology, Trinity College Dublin, Dublin, Ireland;
Catherine
C
Kiely
School of Medicine, Department of Physiology, Trinity College Dublin, Dublin, Ireland;
Joel
J
Rocha
School of Medicine, Department of Physiology, Trinity College Dublin, Dublin, Ireland;
Eamonn
E
O'Connor
Endocrinology, St. Columcille's and St. Vincent's Hospitals, Dublin, Ireland; and.
Donal
D
O'Shea
School of Science and Health and School of Medicine, University of Western Sydney, Sydney, Australia.
Simon
S
Green
School of Medicine, Department of Physiology, Trinity College Dublin, Dublin, Ireland; megana@tcd.ie.
Mikel
M
Egaña
D000328:Adult; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007700:Kinetics; D008593:Menopause; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*
V̇o2 kinetics; age; cardiac output; cycling; women