The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine.
Natural products are important sources of therapeutic drugs. However, it is a challenge to simplify the structure of natural products without decreasing the biological activity. Here we provide the first example of the successful simplification of an antifungal natural product. Starting from sampangine, two novel simplified scaffolds with excellent antifungal activity were discovered.
School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. shengcq@hotmail.com wangyansmmu@126.com.
Zhigan
Z
Jiang
Na
N
Liu
Dandan
D
Hu
Guoqiang
G
Dong
Zhenyuan
Z
Miao
Jianzhong
J
Yao
Haiying
H
He
Yuanying
Y
Jiang
Wannian
W
Zhang
Yan
Y
Wang
Chunquan
C
Sheng
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D018441:Biofilms; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D055808:Drug Discovery; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009287:Naphthyridines
D000470:Alkaloids; D000935:Antifungal Agents; D001688:Biological Products; D006576:Heterocyclic Compounds, 4 or More Rings; D009287:Naphthyridines; C121572:sampangine