Utilization of Copper-Catalyzed Carboarylation-Ring Closure for the Synthesis of New Oxazoline Derivatives.
A copper-catalyzed carboarylation-ring-closure strategy was used for the modular synthesis of oxazolines via the reaction of 1-aryl- and 1-alkylpropargylamides and diaryliodonium salts. The novel approach enables the efficient, modular synthesis of oxazoline derivatives bearing fully substituted exo double bonds.
MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös University , Pázmány Péter stny. 1/a, H-1117 Budapest, Hungary.
Ádám
Á
Sinai
MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös University , Pázmány Péter stny. 1/a, H-1117 Budapest, Hungary.
Dóra
D
Vangel
Servier Research Institute of Medicinal Chemistry , Záhony utca 7, H-1031 Budapest, Hungary.
Tamás
T
Gáti
Research Centre for Natural Sciences of the Hungarian Academy of Sciences , Magyar Tudósok körútja 2, H-1117 Budapest, Hungary.
Petra
P
Bombicz
MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös University , Pázmány Péter stny. 1/a, H-1117 Budapest, Hungary.
Zoltán
Z
Novák