[Endogenous erythropoietin, acute kidney injury, and prognosis in patients with acute coronary syndrome].
OBJECTIVE
To investigate the prognostic value of serum endogenous erythropoietin (EPO) in patients with acute coronary syndrome (ACS), including that in the development of acute kidney injury (AKI).


METHODS
Eighty-four patients (46 men, 38 women; mean age 63 ± 11 years) with ACS were examined. Twenty-one (25%) patents were diagnosed with ECG ST-segment elevation acute myocardial infarction (STSEAMI), 12 (14%) had ECG non-STSEAMI, and 51 (61%) had unstable angina. Thrombolytic therapy was performed in 10 (48%) patients with STSEAMI. The patients whom had not undergone coronarography were included in the investigation to exclude the nephrotoxic effect of X-ray contrast agents.


RESULTS
AKI was observed in 7 of the patients with acute myocardial infarction and in only 1 of those with unstable angina. Four (5%) patients died during hospitalization. The EPO level of > 10.5 IU/ml predicted the development of AKI in the ACS patients with a sensitivity of 71% and a specificity of 67%. That of > 13.7 IU/ml was associated with hospital death in the ACS patients with a sensitivity of 100% and a specificity of 75% (AUC = 0.93%).


CONCLUSIONS
High serum EPO levels in an ACS patent during his hospital stay may serve as a biomarker for a high risk for AKI and high death rates.
Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia.
M V
MV
Menzorov
Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia.
A M
AM
Shutov
Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia.
N V
NV
Larionova
Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia.
E V
EV
Mikhailova
Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia.
I V
IV
Morozova
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D058186:Acute Kidney Injury / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D004562:Electrocardiography; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D015415:Biomarkers; D004921:Erythropoietin