Giant Filiform Polyposis not Associated with Inflammatory Bowel Disease: A Case Report.
BACKGROUND
Filiform polyposis (FP) is an uncommon cause of non-neoplastic and non-syndromic polyposis. Several hypotheses concerning its pathogenesis have been published. FP is most frequently associated with a post-inflammatory reparative process; indeed, the most frequent association is with inflammatory bowel disease (IBD). FP is characterized by one to hundreds of uniform, slender, arborizing, vermiform projections of the large bowel mucosa and submucosa lined by normal or inflamed colonic mucosa. The most common sites for these polyps are the transverse and descending colon.


METHODS
In this report we present a case of giant FP associated with locally invasive adenocarcinoma of the right colon in a 73-year-old man with no past medical history of IBD.


CONCLUSIONS
Few of these cases have been reported in the literature, and out of the approximately 20 of such case reports only one other was associated with colorectal adenocarcinoma.
Pathology Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Rossella
R
Ponte
Pathology Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy ; IRCCS AOU San Martino IST, Genoa, Italy.
Luca
L
Mastracci
IRCCS AOU San Martino IST, Genoa, Italy ; Oncological Surgery Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Stefano
S
Di Domenico
Oncological Surgery Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Carlotta
C
Ferretti
IRCCS AOU San Martino IST, Genoa, Italy ; Oncological Surgery Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Franco
F
De Cian
Pathology Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy ; IRCCS AOU San Martino IST, Genoa, Italy.
Roberto
R
Fiocca
Pathology Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy ; IRCCS AOU San Martino IST, Genoa, Italy.
Federica
F
Grillo
Filiform polyposis; Large bowel; Non-neoplastic