Association between NCF4 rs4821544T/C polymorphism and inflammatory bowel disease risk in Caucasian: a meta-analysis.
OBJECTIVE
Published studies on the association between NCF4 rs4821544T/C polymorphism and inflammatory bowel disease (IBD) risk in Caucasian have yielded conflicting results. The present study aimed to provide more reliable conclusions by conducting a meta-analysis.


METHODS
All eligible studies were extracted from Wiley Online Library, Chinese National Knowledge Infrastructure and PubMed databases. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the associations between rs4821544T/C polymorphism and IBD risk in Caucasian.


RESULTS
A total of 13 case-control studies comprising 7441 Crohn's disease (CD) patients, 2565 ulcerative colitis (UC) patients and 8315 controls were included in this meta-analysis. Significant associations were found between CD and the rs4821544T/C polymorphism in three genetic models (C vs T: OR = 1.11, 95 % CI: 1.06, 1.16, P = 0.000; CC vs TT: OR = 1.31, 95 % CI: 1.18, 1.45, P = 0.000; CC/TC vs TT: OR = 1.07, 95 % CI: 1.01, 1.13, P = 0.014; CC vs
OR = 1.28, 95 % CI: 1.16, 1.42, P = 0.000). However, significant associations were not found in UC under any genetic models (C vs T: OR = 1.04, 95 % CI: 0.97, 1.11, P = 0.264; CC vs TT: OR = 1.10, 95 % CI: 0.93, 1.30, P = 0.284; TC vs TT: OR = 1.04, 95 % CI: 0.95, 1.13, P = 0.429; CC/TC vs TT: OR = 1.04, 95 % CI: 0.95, 1.13, P = 0.390; CC vs
OR = 1.07, 95 % CI: 0.91, 1.26, P = 0.409).


CONCLUSIONS
This meta-analysis suggested that the rs4821544T/C polymorphism was associated with CD, but not UC in Caucasian.
Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, Wuhan, Hubei, China.
Peng-Bo
PB
Wu
Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, Wuhan, Hubei, China.
Jin-Fen
JF
Dai
Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, Wuhan, Hubei, China.
Qian
Q
Wang
Department of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region, 35 Taoyuan Rd, Guangxi, China.
Guo
G
Zhang
Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, Wuhan, Hubei, China. tan05shiyun@gmail.com.
Shi-Yun
SY
Tan
Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, Wuhan, Hubei, China.
Ming
M
Li
Department of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region, 35 Taoyuan Rd, Guangxi, China.
Hui-Lan
HL
Ye
D016022:Case-Control Studies; D005787:Gene Frequency; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology* / Q000235:genetics*; D019255:NADPH Oxidases / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People
D019255:NADPH Oxidases; C113333:NCF4 protein, human
Inflammatory bowel disease; Meta-analysis; NCF4; Polymorphism