Evaluation of circulating betatrophin levels in gestational diabetes mellitus.
Experimental data indicate that betatrophin plays a significant role in the regulation of lipid metabolism and glucose homeostasis. In recent years, considerable attention has focused on the relationship between betatrophin and diabetes mellitus in humans. This case-control study included 45 women diagnosed with gestational diabetes mellitus (GDM) and 45 pregnant healthy controls. The groups were matched for maternal and gestational age and body mass index. Serum betatrophin levels were significantly higher in women with GDM (median = 635.8 ng/L; range: 290-1841.6 ng/L) compared to control subjects (median = 320.1 ng/L; range: 94.6-936.8 ng/L; p = 0.001). No significant correlations were observed between serum betatrophin levels and clinical or biochemical parameters in the control group. However, in the GDM group, serum betatrophin levels were positively correlated with weight gain during pregnancy (r = 0.304, p = 0.042), systolic blood pressure (r = 0.394, p = 0.007), fasting insulin level (r = 0.348, p = 0.019), and homeostatic model assessment insulin resistance (HOMA-IR; r = 0.311, p = 0.038). Multivariate stepwise linear regression analysis revealed that fasting insulin levels (β = 0.342, p = 0.022) and HOMA-IR (β = 0.312, p = 0.037) were independently associated with serum betatrophin levels.
a Department of Obstetrics and Gynecology and.
Onur
O
Erol
b Department of Biochemistry , Antalya Training and Research Hospital , Antalya , Turkey.
Hamit Yaşar
HY
Ellidağ
a Department of Obstetrics and Gynecology and.
Hülya
H
Ayık
a Department of Obstetrics and Gynecology and.
Mustafa Kemal
MK
Özel
a Department of Obstetrics and Gynecology and.
Aysel Uysal
AU
Derbent
b Department of Biochemistry , Antalya Training and Research Hospital , Antalya , Turkey.
Necat
N
Yılmaz
D000328:Adult; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001786:Blood Glucose; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005215:Fasting / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D036361:Peptide Hormones / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001786:Blood Glucose; D007328:Insulin; D036361:Peptide Hormones
Betatrophin; gestational diabetes mellitus; insulin resistance