Dengue Non-coding RNA: TRIMmed for Transmission.
Dengue virus RNA is trimmed by the 5'→3' exoribonuclease XRN1 to produce an abundant, non-coding subgenomic flavivirus RNA (sfRNA) in infected cells. In a recent paper in Science, Manokaran et al. (2015) report that sfRNA binds TRIM25 to evade innate immune sensing of viral RNA by RIG-I.
Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708PB, Wageningen, the Netherlands.
Giel P
GP
Göertz
Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708PB, Wageningen, the Netherlands. Electronic address: gorben.pijlman@wur.nl.
Gorben P
GP
Pijlman
D000818:Animals; D003715:Dengue / Q000276:immunology* / Q000821:virology*; D003716:Dengue Virus / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology*; D012367:RNA, Viral / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014779:Virus Replication
D007370:Interferon Type I; D012367:RNA, Viral; D014157:Transcription Factors; D044767:Ubiquitin-Protein Ligases