Acral Acanthosis Nigricans in a Case of Scleroderma.
Acanthosis nigricans (AN) is a dermatosis characterized by velvety, papillomatous, brownish-black, hyperkeratotic plaques, typically on the intertriginous surfaces and neck. The majority (80%) of AN occurs idiopathically or in benign conditions such as endocrinopathies like diabetes mellitus, polycystic ovary syndrome; metabolic syndrome and/or heritable disease. Malignancy-associated AN is rare. AN may rarely be associated with autoimmune diseases including systemic lupus erythematosus, due to antibodies to the insulin receptor, so-called type B insulin resistance. Here we report a case of AN in a case of diffuse progressive systemic sclerosis without evidence of insulin resistance.
Department of Dermatology, Venereology and Leprosy, Grant Government Medical College and Sir Jamsetjee Jeejebhoy Group of Hospitals, Mumbai, Maharashtra, India.
Mahendra M
MM
Kura
Department of Dermatology, Venereology and Leprosy, Grant Government Medical College and Sir Jamsetjee Jeejebhoy Group of Hospitals, Mumbai, Maharashtra, India.
Swapnil A
SA
Sanghavi
Acanthosis nigricans; acral; scleroderma