Association between interferon gamma 13-CA-repeats polymorphism and metastasis of nasopharyngeal carcinoma in a population of Northern China.
Interferon Gamma gamma (IFN-γ) 13-CA-repeats polymorphism is associated with a variety of diseases; here we report its association with nasopharyngeal carcinoma (NPC) metastasis in a retrospective analysis of a cohort of 220 NPC patients in the northern China. The results showed that the distributions of CA13-/CA13-genotypes were significantly higher in the patients with lymph node metastasis (P<0.05) and distant metastasis (P<0.001); there was a significant difference between NPC patients with stage I+II and those with stage III+IV regarding CA13+/CA13-(P<0.001) and CA13-/CA13- genotypes (P<0.001); further analysis showed a more pronounced difference between NPC patients with stage I+II+III and those with stage IV for CA13-/CA13-genotype (P<0.001), whereas no difference was found for CA13+/CA13- genotype (P=0.790). Thus, we identify that IFN-γ 13-CA-repeat polymorphism is significantly associated with the metastasis of NPC, which may provide insights into its prognosis and individualized treatment.
Department of Otorhinolaryngology & Head and Neck Surgery, Tianjin Third Central Hospital Tianjin, China.
Kaifei
K
Hao
Department of Otorhinolaryngology & Head and Neck Surgery, Tianjin Third Central Hospital Tianjin, China.
Zhaohui
Z
Yan
Department of Maxillofacial & ENT Oncology, Tianjin Medical University Cancer Institute and Hospital Tianjin, China.
Yu
Y
Shuang
Department of Radiotherapy, Affilliated Hospital of Logistics University of Chinese People's Armed Police Forces Tianjin, China.
Jinsong
J
Sun
Department of Otorhinolaryngology & Head and Neck Surgery, Tianjin Third Central Hospital Tianjin, China.
Shudong
S
Tao
Department of Otorhinolaryngology & Head and Neck Surgery, Tianjin Third Central Hospital Tianjin, China.
Wenyuan
W
Fu
Department of Otorhinolaryngology & Head and Neck Surgery, Tianjin Third Central Hospital Tianjin, China.
Lei
L
Liu
D044466:Asian People / Q000235:genetics*; D002277:Carcinoma; D016022:Case-Control Studies; D002681:China; D042622:DNA Repeat Expansion; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D012189:Retrospective Studies
D007371:Interferon-gamma
Polymorphism; interferon gamma; metastasis; nasopharyngeal carcinoma