[Exploration of novel therapeutic targets for neuropathic pain based on the regulation of immune cells].
The pathogenesis of neuropathic pain is quite complicated and diverse. Because pre-existing analgesics, such as opioid analgesics and nonsteroidal anti-inflammatory drugs, are not sufficient to treat it, it is a serious task to establish a strategy of remedy for neuropathic pain. Recently, increasing evidence suggests that immune cell-mediated neuroinflammation in the nervous system induces central and peripheral sensitization, resulting in chronic pain. Initially, the immune system plays an important role in host defense. Although intravital homeostasis is kept constant by innate and adaptive immunity, the immune system is activated excessively due to infection, stress and tissue injury. Activated immune cells produce and release several kinds of inflammatory mediators, which act directly on sensory neurons and promote a recruitment of immune cells, developing the feedback loop of inflammatory exacerbation. We've focused on the role of crosstalk between immune cells and neurons in peripheral neuroinflammation, and explored a novel candidate for a remedy of neuropathic pain. In this review, we will introduce recent reports and our research work that suggest the functional significance of neuroinflammation in neuropathic pain, and survey possibilities of new strategies for chronic pain from the point of view of basic research.
Yuka
Y
Kobayashi
Norikazu
N
Kiguchi
Fumihiro
F
Saika
Shiroh
S
Kishioka
D000818:Animals; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000276:immunology*; D060889:Inducible T-Cell Co-Stimulator Protein / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D051379:Mice; D058990:Molecular Targeted Therapy; D009437:Neuralgia / Q000188:drug therapy* / Q000276:immunology*; D020078:Neurogenic Inflammation / Q000276:immunology*; D011984:Sensory Receptor Cells / Q000276:immunology
D018925:Chemokines; D016207:Cytokines; D060889:Inducible T-Cell Co-Stimulator Protein; D018836:Inflammation Mediators