[Research progress in carcinogenicity of trichloroethylene and its metabolites].
Trichlorethylene (TCE) is a widely used organic solvent and an important industrial material. It's easily released into the environment through manufacture, use and disposal process, so there is a wide range of occupationally and environmentally exposed population. Based on accumulated research data, International Agency for Research on Cancer (IARC) increased the carcinogenic rating of TCE from probable human carcinogen to certain human carcinogen in 2012. This paper is a review of the carcinogenic effects of TCE and its metabolites from the aspects of epidemiological data, experimental evidence on animals as well as the mechanisms of carcinogenesis.
Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Peiwu
P
Huang
Xuan
X
Li
Xiaohu
X
Ren
Email: bio-research@hotmail.com.
Jianjun
J
Liu
D000818:Animals; D002273:Carcinogens; D006801:Humans; D014241:Trichloroethylene
D002273:Carcinogens; D014241:Trichloroethylene