Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: A case-control study.
OBJECTIVE
To examine the platelet recovering and anti-inflammatory effects of IL-11 in the treatment of sepsis, accompanied with thrombocytopenia and to investigate the associated mechanisms via a case-control study.


METHODS
105 patients enrolled for the study were segregated into (1) IL-11 therapy group and (2) conventional therapy group. The IL-11 therapy group was given additional recombinant human IL-11 treatment. Laboratory examinations of IL-11, IL-6, TNF-α, PT, APTT, WBC, PLT counts in blood routine assays and PCT, CRP and APACHE II scores were performed and the results were recorded.


RESULTS
The PLT counts in the IL-11 therapy group were higher than those in the conventional therapy group. No obvious difference in WBC counts or CRP levels was observed between the two groups. The highest levels of TNF-α were observed on day 3 in the conventional therapy group while it was observed on day 1 in the IL-11 therapy group, both of which subsequently declined gradually. The level of IL-6 was significantly lower in the IL-11 therapy group from 3 to 14 days, while there was a gradual elevation of IL-11. IL-11 therapy downregulated the expression of the sepsis indicator PCT and reduced the APACHE II score from 3 to 14 days. The conventional therapy group had a significantly higher mortality rate within 28 days.


CONCLUSIONS
IL-11 has a protective role and can accelerate recovery of platelets, and remarkably lessen the extent of inflammatory responses, hence reducing the mortality in sepsis patients accompanied with thrombocytopenia.
Department of ICU, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Bing
B
Wan
Emergency Medicine Center, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Hao
H
Zhang
Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Haiyan
H
Fu
Emergency Medicine Center, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. Electronic address: andiantong@163.com.
Yikun
Y
Chen
Emergency Medicine Center, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Liping
L
Yang
Department of ICU, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Jiangtao
J
Yin
Clinical Laboratory, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Yin
Y
Wan
Emergency Medicine Center, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Yongqing
Y
Shi
D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D002116:Calcitonin / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000628:therapy; D017370:Interleukin-11 / Q000009:adverse effects / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011498:Protein Precursors / Q000097:blood; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D018805:Sepsis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology* / Q000401:mortality; D013921:Thrombocytopenia / Q000150:complications / Q000188:drug therapy* / Q000276:immunology* / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
C508611:IL11 protein, human; C508600:IL6 protein, human; D017370:Interleukin-11; D015850:Interleukin-6; D011498:Protein Precursors; D011994:Recombinant Proteins; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D002116:Calcitonin
Inflammation; Interleukin-11; Sepsis; Thrombocytopenia