In Vitroandin VivoAnti-Diabetic Effects of Anthocyanins from Maqui Berry (Aristotelia chilensis).
We used a murine model of type II diabetes, which reproduces the major features of the human disease, and a number of cellular models to study the antidiabetic effect of ANC, a standardised anthocyanin-rich formulation from maqui berry (Aristotelia chilensis). We also isolated delphinidin 3-sambubioside-5-glucoside (D3S5G), a characteristic anthocyanin from maqui berry, and studied its antidiabetic properties. We observed that oral administration of ANC improved fasting blood glucose levels and glucose tolerance in hyperglycaemic obese C57BL/6J mice fed a high fat diet. In H4IIE rat liver cells, ANC decreased glucose production and enhanced the insulin-stimulated down regulation of the gluconeogenic enzyme, glucose-6-phosphatase. In L6 myotubes ANC treatment increased both insulin and non-insulin mediated glucose uptake. As with the ACN, oral administration of pure D3S5G dose-dependently decreased fasting blood glucose levels in obese C57BL/6J mice, and decreased glucose production in rat liver cells. D3S5G also increased glucose uptake in L6 myotubes and is at least partially responsible for ANC's anti-diabetic properties.
Rutgers University, SEBS, New Brunswick, NJ 08901.
Leonel E
LE
Rojo
Rutgers University, SEBS, New Brunswick, NJ 08901.
David
D
Ribnicky
Rutgers University, SEBS, New Brunswick, NJ 08901.
Sithes
S
Logendra
Rutgers University, SEBS, New Brunswick, NJ 08901.
Alex
A
Poulev
Rutgers University, SEBS, New Brunswick, NJ 08901.
Patricio
P
Rojas-Silva
Rutgers University, SEBS, New Brunswick, NJ 08901.
Peter
P
Kuhn
Rutgers University, SEBS, New Brunswick, NJ 08901.
Ruth
R
Dorn
North Carolina State University, Kannapolis, NC, USA.
Mary H
MH
Grace
North Carolina State University, Kannapolis, NC, USA.
Mary Ann
MA
Lila
Rutgers University, SEBS, New Brunswick, NJ 08901.
Ilya
I
Raskin
Dietary Anthocyanins; Glucose Metabolism; Maqui Berry; Metabolic Syndrome