Role of acetylcholinesterase in lung cancer.
Acetylcholinesterase (AChE) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters. Intensive research has proven the involvement of this protein in novel functions, such as cell adhesion, differentiation, and proliferation. In addition, several recent studies have indicated that acetylcholinesterase is potentially a marker and regulator of apoptosis. Importantly, AChE is also a promising tumor suppressor. In this review, we briefly summarize the involvement of AChE in apoptosis and cancer, focusing on the role of AChE in lung cancer, as well as the therapeutic consideration of AChE for cancer therapy.
Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University Shanghai, China.
Hui-Jun
HJ
Xi
Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University Shanghai, China.
Ren-Pei
RP
Wu
School of Nursing, Second Military Medical University Shanghai, China.
Jing-Jing
JJ
Liu
Department of Nursing, Changhai Hospital, Second Military Medical University Shanghai, China.
Ling-Juan
LJ
Zhang
Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University Shanghai, China ; Department of Gastroenterology, Changhai Hospital, Second Military Medical University Shanghai, China.
Zhao-Shen
ZS
Li
Acetylcholinesterase (AChE); apoptosis; biomarker; lung cancer