15-PGDH expression as a predictive factor response to neoadjuvant chemotherapy in advanced gastric cancer.
Given the various clinical and pathologic responses to neoadjuvant chemotherapy (NACT) in gastric cancer (GC), potential biomarkers that reflecting the efficacy of NACT on GC should be investigated. The aim of this study was to investigate the 15-PGDH expression response to NACT in GC patients and its relationship with prognosis of GC. Immunohistochemical method was used to assess the level of 15-PGDH expression in 56 GC patients who received NACT before surgery and 46 patients who underwent surgical treatment without NACT as well as their corresponding adjacent non-neoplastic tissues. We found that there was no correlation of 15-PGDH expression between non-cancerous gastric tissues and GC tissues (P=0.519), while 15-PGDH expression level in NACT group was higher than that in nNACT group (P=0.015). In patients with NACT, the higher level of 15-PGDH expression was significantly associated with well-moderately differentiated grade (P=0.023), I/II stage (P=0.014) and with no lymph node metastasis (P=0.016). Moreover, statistically significant differences in overall survival (OS) were found among 15-PGDH expression (log-rank test, P<0.001) and TNM stage (log-rank test, P=0.032). Most importantly, expression of 15-PGDH was found to be an independent predictive factor by multivariate analysis (Hazard ratio (HR) 0.315 [0.120-0.827], P=0.019). These findings indicated that NACT could increase 15-PGDH expression in advanced GC patients, and 15-PGDH may serve as a candidate prognostic biomarker of advanced GC response to NACT.
Department of Pathology, Zhongnan Hospital of Wuhan University Wuhan 430071, China.
Min
M
Hu
Department of Pathology, Zhongnan Hospital of Wuhan University Wuhan 430071, China.
Kai
K
Li
Department of Pathology, Zhongnan Hospital of Wuhan University Wuhan 430071, China.
Ninu
N
Maskey
Department of Pathology, Zhongnan Hospital of Wuhan University Wuhan 430071, China.
Zhigao
Z
Xu
Department of Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071, China.
ChunWei
C
Peng
Department of Pathology, Zhongnan Hospital of Wuhan University Wuhan 430071, China.
Sufang
S
Tian
Department of Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071, China.
Yan
Y
Li
Department of Pathology, Zhongnan Hospital of Wuhan University Wuhan 430071, China.
Guifang
G
Yang
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002454:Cell Differentiation; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000378:metabolism*; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D018579:Patient Selection; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D006911:Hydroxyprostaglandin Dehydrogenases; C035859:15-hydroxyprostaglandin dehydrogenase
15-hydroprostaglandin dehydrogenase (15-PGDH); Gastric cancer; biomarker; immunohistochemistry (IHC); neoadjuvant chemotherapy (NACT)