Immunogenicity of pneumococcal vaccination in a patient with sickle hemoglobinopathy: a case report.
Despite decrease in morbidity and mortality from invasive pneumococcal disease (IPD), individuals with asplenia remain at risk for IPD compared to the general population. This report describes a young adult with hemoglobin SD and documented splenic autoinfarction with pneumococcal sepsis, meningitis, and pneumonia within seven months of immunization with PPSV-23.
Division of Hematology and Oncology, Departments of Pediatrics and Internal Medicine, Georgia Regents University Augusta, Georgia, USA.
E Leila Jerome
EL
Clay
Department of Pediatrics, University of Cincinnati Cincinnati, Ohio, USA.
Tierra
T
Burrell
Division of Infectious Disease, Department of Pediatrics, University of North Carolina School of Medicine Chapel Hill, North Carolina, USA.
Thomas
T
Belhorn
Division of Hematology and Oncology, Departments of Pediatrics and Internal Medicine, University of North Carolina School of Medicine Chapel Hill, North Carolina, USA.
Rupa
R
Redding-Lallinger
Invasive pneumococcal disease; PPSV-23; Streptococcal Pneumonia; sickle cell disease