Chronic Renal Insufficiency Cohort Study (CRIC): Overview and Summary of Selected Findings.
The Chronic Renal Insufficiency Cohort (CRIC) Study is a United States multicenter, prospective study of racially and ethnically diverse patients with CKD. Although the original aims of the study were to identify novel predictors of CKD progression and to elucidate the risk and manifestations of cardiovascular disease among nearly 4000 individuals with CKD, the CRIC Study has evolved into a national resource for investigation of a broad spectrum of CKD-related topics. The study has produced >90 published scientific articles, promoted many young investigative careers in nephrology, and fostered international collaborations focused on understanding the global burden of CKD. The third phase of the CRIC Study will complete enrollment of 1500 additional study participants in 2015 and is designed to answer questions regarding morbidity and mortality in mild-to-moderate CKD and to assess the burden of CKD in older persons. This review highlights some of the salient findings of the CRIC Study in the areas of race and ethnicity, CKD progression, CKD and cognition, and cardiovascular disease outcomes; it also outlines the ongoing and forthcoming opportunities for the global nephrology community to enhance its understanding of CKD and related complications through the study.
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Matthew
M
Denker
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Suzanne
S
Boyle
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Amanda H
AH
Anderson
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Lawrence J
LJ
Appel
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Jing
J
Chen
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Jeffrey C
JC
Fink
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
John
J
Flack
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Alan S
AS
Go
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Edward
E
Horwitz
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Chi-Yuan
CY
Hsu
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
John W
JW
Kusek
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
James P
JP
Lash
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Sankar
S
Navaneethan
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Akinlolu O
AO
Ojo
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Mahboob
M
Rahman
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Susan P
SP
Steigerwalt
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Raymond R
RR
Townsend
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material. hfeldman@mail.med.upenn.edu.
Harold I
HI
Feldman
D002318:Cardiovascular Diseases / Q000209:etiology; D015331:Cohort Studies; D018450:Disease Progression; D006801:Humans; D044469:Racial Groups; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000453:epidemiology
chronic kidney disease; chronic renal insufficiency; cohort study