[Pulmonary Langerhans cell histiocytosis].
Pulmonary Langerhans cell histiocytosis is regarded as a reactive proliferation of the dendritic Langerhans cell population stimulated by chronic tobacco-derived plant proteins due to incomplete combustion but can also occur in childhood as a tumor-like systemic disease. Currently, both these forms cannot be morphologically distinguished. In the lungs a nodular proliferation of Langerhans cells occurs in the bronchial mucosa and also peripherally in the alveolar septa with an accompanying infiltration by eosinophilic granulocytes and destruction of the bronchial wall. Langerhans cells can be selectively detected with antibodies against CD1a and langerin. In the reactive isolated pulmonary form, abstinence from tobacco smoking in most patients leads to regression of infiltration and improvement of symptoms. In high-resolution computed tomography (HRCT) the small star-like scars can still be detected even after complete cessation of tobacco smoking.
Forschungseinheit Molekulare Lungen- & Pleurapathologie, Institut für Pathologie, Medizinische Universität Graz, Auenbruggerplatz 25, 8036, Graz, Österreich, helmut.popper@medunigraz.at.
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D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1 / Q000032:analysis; D049109:Cell Proliferation / Q000502:physiology; D002648:Child; D003713:Dendritic Cells / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D037181:Lectins, C-Type / Q000032:analysis; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000473:pathology* / Q000628:therapy; D037241:Mannose-Binding Lectins / Q000032:analysis; D008854:Microscopy, Electron; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation; D014057:Tomography, X-Ray Computed
D015703:Antigens, CD; D018949:Antigens, CD1; C121916:CD207 protein, human; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins