Association between Hyperuricemia and Metabolic Syndrome: An Epidemiological Study of a Labor Force Population in Taiwan.
The increasing prevalence of metabolic syndrome (MetS) has become an important issue worldwide. Metabolic comorbidities of hypertension, obesity, and hyperlipidemia are shown as important risk factors for incident gout. The purpose of this study was to investigate the relationship between hyperuricemia and MetS. This is a cross-sectional study. The effective sample included 21,544 individuals who received worker health examinations at a local teaching hospital in Changhua County from 2008~2012. We used multiple logistic regression analysis to investigate the influences of hyperuricemia on MetS. The results showed that individuals with MetS had significantly higher blood pressure, fasting plasma glucose, triglycerides, waist circumference, and high-density lipoprotein cholesterol than those without MetS (P < 0.001). Multiple logistic regression analysis revealed hyperuricemia to be an important factor of MetS. The risk of developing MetS is higher with high levels of serum uric acid (SUA) and the odds ratio (OR) of having MetS is 4.98 times higher for Tertile 3 than for Tertile 1 (95% CI = 4.16-5.97) and 4 times higher for Quartile 4 than for Quartile 1 (95% CI = 3.59-4.46). In conclusion, males are more likely to develop MetS than females, and the risk of having MetS increases with age and SUA concentration.
Department of Neurology, Show Chwan Memorial Hospital, Changhua County 50008, Taiwan ; Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua County 50544, Taiwan ; Department of Exercise and Health Promotion, College of Education, Chinese Culture University, Taipei City 11114, Taiwan.
Cheng-Yu
CY
Wei
Physical Examination Center, Show Chwan Memorial Hospital, Changhua County 50008, Taiwan.
Chia-Cheng
CC
Sun
Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University, Taichung City 40201, Taiwan.
James Cheng-Chung
JC
Wei
Department of Exercise and Health Promotion, College of Education, Chinese Culture University, Taipei City 11114, Taiwan.
Hsu-Chih
HC
Tai
Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Chien-An
CA
Sun
Sleep Center, Chang Bing Show-Chwan Memorial Hospital, Changhua County 50544, Taiwan.
Chian-Fang
CF
Chung
School of Public Health, National Defense Medical Center, Taipei City 11490, Taiwan.
Yu-Ching
YC
Chou
Department of Nursing, Meiho University, Pingtung County 91202, Taiwan.
Pi-Li
PL
Lin
Department of Health Business Administration, Meiho University, Pingtung County 91202, Taiwan.
Tsan
T
Yang
D000328:Adult; D001786:Blood Glucose / Q000502:physiology; D001794:Blood Pressure / Q000528:radiation effects; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D004651:Employment; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000150:complications*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D055105:Waist Circumference / Q000502:physiology; D055815:Young Adult
D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D014527:Uric Acid