Recollection of How We Came Across the Protein Modification with Amino Acids by Aminoacyl tRNA-Protein Transferase.
Protein arginylation has been discovered in 1963 as a soluble activity in cell extracts that mediates addition of amino acids to proteins. This discovery was nearly accidental, but due to the persistence of the research team, it has been followed through and led to the emergence of a new field of research. This chapter describes the original discovery of arginylation and the first methods used to demonstrate the existence of this important biological process.
Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 19107, USA, Hideko.Kaji@jefferson.edu.
Hideko
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Kaji
Akira
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Kaji
D000596:Amino Acids / Q000378:metabolism*; D019881:Aminoacyltransferases / Q000378:metabolism*; D000818:Animals; D049673:History, 20th Century; D006801:Humans; D011499:Protein Processing, Post-Translational; D012106:Research / Q000266:history
D000596:Amino Acids; D019881:Aminoacyltransferases; C019675:tRNA-protein transferase, amino acyl