Whole-Saliva Fluoride Levels and Saturation Indices in 65+ Elderly during Use of Four Different Toothpaste Regimens.
BACKGROUND
Elderly individuals suffering from subnormal saliva secretion combined with inadequate oral hygiene may develop rampant caries and caries in parts of the dentition not normally affected by caries if preventive measures are not undertaken. Such measures include elevating fluoride levels at the saliva/biofilm/tooth interface.


OBJECTIVE
To analyse whole-saliva fluoride levels and mineral saturation indices during different fluoride toothpaste regimens in home-living elderly.


METHODS
Whole saliva was collected from 27 subjects (7 males and 20 females, mean age 73.5±6.1 years) at ten time points covering the whole day during five 2-week periods. During the first period, participants used their normal toothpaste without instructions (baseline). This was followed by TP1: 1,450-ppm NaF toothpaste; TP2: 1,450-ppm monofluorophosphate (MFP) toothpaste with addition of calcium; TP3: 5,000-ppm NaF toothpaste, and TP4: the same toothpaste with additional 'smearing' of toothpaste on the teeth, twice daily. During TP1-TP4, the participants were instructed to brush 3 times per day using 1.5 g of toothpaste without rinsing.


RESULTS
Salivary fluoride levels increased with toothpaste fluoride content (p<0.001), although major interindividual and intraindividual variations were observed. The highest fluoride values appeared in the morning and at night (p<0.001). Saturation indices for calcium fluoride were affected by the fluoride content in pastes (p<0.05). Concerning hydroxyapatite and fluorapatite, indices were highest with the MFP toothpaste and extra calcium (NS to p<0.05).


CONCLUSIONS
Use of a high-fluoride toothpaste resulted in significantly increased fluoride levels in whole saliva and mineral saturation indices were indeed influenced by choice of toothpaste.
Section of Cariology and Endodontics, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kim Rud
KR
Ekstrand
Mia Linding
ML
Ekstrand
Joan
J
Lykkeaa
Allan
A
Bardow
Svante
S
Twetman
D000368:Aged; D000369:Aged, 80 and over; D002327:Cariostatic Agents / Q000008:administration & dosage; D003731:Dental Caries / Q000517:prevention & control*; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis*; D006801:Humans; D008297:Male; D008903:Minerals / Q000032:analysis; D009910:Oral Hygiene / Q000379:methods*; D010710:Phosphates / Q000008:administration & dosage; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012969:Sodium Fluoride / Q000008:administration & dosage; D014099:Toothbrushing / Q000379:methods; D014100:Toothpastes / Q000008:administration & dosage*
D002327:Cariostatic Agents; D008903:Minerals; D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides