A multi-stimuli responsive, self-assembling, boronic acid dipeptide.
Modification of the dipeptide of phenylalanine, FF, with a boronic acid (BA) functionality imparts unique aqueous self-assembly behavior that responds to multiple stimuli. Changes in pH and ionic strength are used to trigger hydrogelation via the formation of nanoribbon networks. Furthermore, we show for the first time that the binding of polyols to the BA functionality can modulate a peptide between its assembled and disassembled states.
Electronic, Optical, and Nano Materials, Sandia National Laboratories, Albuquerque, NM 87185, USA. edspoer@sandia.gov.
Brad H
BH
Jones
Alina M
AM
Martinez
Jill S
JS
Wheeler
Bonnie B
BB
McKenzie
Lance L
LL
Miller
David R
DR
Wheeler
Erik D
ED
Spoerke
D001897:Boronic Acids / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration
D001897:Boronic Acids; D004151:Dipeptides