PROTEIN NEEDS OF CRITICALLY ILL PATIENTS RECEIVING PARENTERAL NUTRITION.
BACKGROUND
assess whether the current protein intake recommendations may improve the biochemical parameters of critical patients receiving parenteral nutrition.


METHODS
longitudinal study with three evaluations made (during the first 72 hours, on the 7th and the 14th days of PN). The following tests were applied: albumin, C-reactive protein, prealbumin, total cholesterol, HDL, triglycerides, lymphocytes, and glutathione peroxidase. The severity was determined by SOFA. The statistical analysis included the Spearman and Mann-Whitney tests, as well as ANOVA (analysis of variance).


RESULTS
among the 53 patients evaluated, 20 (37.74%) died. The mean calorie was 24.68 ± 9.78 kcal/kg (beginning of PN), 26.49 ± 8.89 kcal/kg (3rd to 7th days of PN), and 30.9 ± 12.19 kcal/kg (7th to 14th days of PN). The mean protein was 1.19 ± 0.44 g/kcal/kg (first 72 hours of PN), 1.29 ± 0.44 g/kcal/kg (3rd to 7th days of PN) and 1.49 ± 0.69 g/kcal/kg (7th to 14th days of PN). Prealbumin, albumin, total cholesterol and HDL were below the reference values, while the CRP levels were high. Throughout the three evaluation times, there was no a significant improvement on the levels of laboratory examinations. A strong and negative correlation was found between SOFA and prealbumin (r = -0.64, p = 0.05).


CONCLUSIONS
the protein offer, according to the traditional recommendations, was not enough to improve the biochemical parameters of critical patients undergoing parenteral nutrition.
College of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP. Brazil.. renatagbonfreitas@yahoo.com.br.
Renata
R
Germano Borges de Oliveira Nascimento Freitas
College of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP. Brazil.. nutrigene@uol.com.br.
Roberto José
RJ
Negrão Nogueira
College of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP. Brazil.. ghessel@fcm.unicamp.br.
Gabriel
G
Hessel
D000328:Adult; D000368:Aged; D015415:Biomarkers; D003422:Critical Care / Q000379:methods; D016638:Critical Illness; D002149:Energy Intake; D005260:Female; D006801:Humans; D018836:Inflammation Mediators; D007362:Intensive Care Units; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total
D015415:Biomarkers; D018836:Inflammation Mediators