Intranuclear biophotonics by smart design of nuclear-targeting photo-/radio-sensitizers co-loaded upconversion nanoparticles.
Biophotonic technology that uses light and ionizing radiation for positioned cancer therapy is a holy grail in the field of biomedicine because it can overcome the systemic toxicity and adverse side effects of conventional chemotherapy. However, the existing biophotonic techniques fail to achieve the satisfactory treatment efficacy, which remains a big challenge for clinical implementation. Herein, we develop a novel theranostic technique of "intranuclear biophotonics" by the smart design of a nuclear-targeting biophotonic system based on photo-/radio-sensitizers covalently co-loaded upconversion nanoparticles. These nuclear-targeting biophotonic agents can not only generate a great deal of multiple cytotoxic reactive oxygen species in the nucleus by making full use of NIR/X-ray irradiation, but also produce greatly enhanced intranuclear synergetic radio-/photodynamic therapeutic effects under the magnetic/luminescent bimodal imaging guidance, which may achieve the optimal efficacy in treating radio-resistant tumors. We anticipate that the highly effective intranuclear biophotonics will contribute significantly to the development of biophotonic techniques and open new perspectives for a variety of cancer theranostic applications.
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, PR China.
Wenpei
W
Fan
Institute of Radiation Medicine, Fudan University, PR China.
Bo
B
Shen
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, PR China; Jiangsu Collaborative Innovation Center for Advanced Inorganic Functional Composites, Nanjing Tech University, PR China. Electronic address: wbbu@mail.sic.ac.cn.
Wenbo
W
Bu
Department of Radiation Oncology, Shanghai Huadong Hospital, Fudan University, PR China.
Xiangpeng
X
Zheng
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, PR China.
Qianjun
Q
He
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, PR China.
Zhaowen
Z
Cui
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, PR China.
Dalong
D
Ni
Department of Radiology, Shanghai Cancer Hospital, Fudan University, PR China.
Kuaile
K
Zhao
Department of Radiology, Shanghai Cancer Hospital, Fudan University, PR China.
Shengjian
S
Zhang
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, PR China. Electronic address: jlshi@mail.sic.ac.cn.
Jianlin
J
Shi
D000818:Animals; D002460:Cell Line; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D049408:Luminescent Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000008:administration & dosage / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000068936:Theranostic Nanomedicine
D049408:Luminescent Agents; D017319:Photosensitizing Agents
Intranuclear biophotonics; Magnetic/luminescent bimodal imaging; Photo-/radio-sensitizers; Synergetic radio-/photodynamic therapy; Upconversion nanoparticles