Relationship among MIF, MCP-1, viral loads, and HBs Ag levels in chronic hepatitis B patients.
OBJECTIVE
To determine whether macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis B (HB) are different than in normal individuals and whether the HB surface antigen (HBs Ag) level and viral load are correlated with each other and with the two aforementioned parameters.


METHODS
Sera were obtained from 52 chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and MCP-1 levels were measured. Statistical analyses were performed. A value of P < 0.05 was considered statistically significant.


RESULTS
The MIF and MCP-1 values of the control group were increased compared to those of the CAHB group. The MIF and MCP-1 levels were negatively correlated with HBs Ag levels and viral loads. The MIF and MCP-1 levels were positively correlated. The HBs Ag levels and the log10 of the viral loads were positively correlated.


CONCLUSIONS
We conclude that the negative correlation of MIF and MCP-1 with viral load and HBs Ag levels may be due to T-cell deficiency, antinuclear antibody seropositivity, and/or inhibition of chemokine ligand 2 receptors by viral antigens. More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.
Hayati
H
Güneş
Rafet
R
Mete
Murat
M
Aydin
Birol
B
Topçu
Mustafa
M
Oran
Mustafa
M
Doğan
Oğuzhan
O
Yildirim
Ilknur
I
Erdem
Aynur
A
Eren Topkaya
Ahmet
A
Gürel
D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood* / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D006514:Hepatitis B Surface Antigens / Q000097:blood* / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000235:genetics; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood* / Q000235:genetics; D019562:Viral Load / Q000235:genetics
D015415:Biomarkers; D018932:Chemokine CCL2; D006514:Hepatitis B Surface Antigens; D008263:Macrophage Migration-Inhibitory Factors