Parameters of glucose and lipid metabolism at the fasted state in drug-naïve first-episode patients with psychosis: Evidence for insulin resistance.
Diabetes and dyslipidemia are common in patients with psychosis; this association may be partly related to adverse metabolic effects of antipsychotic medications. We assessed glucose and lipid metabolism during the fasted state in drug-naïve patients with psychosis. Fasting serum concentrations of total cholesterol, triglycerides, high density lipoprotein (HDL), glucose, insulin, connecting peptide (C-peptide), homeostatic model assessment index (HOMA-IR), glycated hemoglobin (HbA1C) and serum cortisol were compared between a group of 40 newly diagnosed drug-naïve, first-episode patients with psychosis and a group of 40 healthy controls, matched for age, sex and BMI. Total cholesterol, triglycerides and fasting glucose levels were similar, whereas insulin and C-peptide levels were higher and HDL marginally lower in the patients' group compared to those in healthy controls. Drug-naïve patients with psychosis were more insulin resistant (as assessed by the HOMA-R index) compared to healthy controls. Serum cortisol did not differ between the two groups. There is evidence that drug-naïve, first-episode patients with psychosis are more insulin resistant compared to healthy controls.
Department of Psychiatry, Medical School, University of Ioannina, P.O. Box 1186, 45110 Ioannina, Greece. Electronic address: ppetrikis@hotmail.gr.
Petros
P
Petrikis
Department of Endocrinology, Medical School, University of Ioannina, 45110 Ioannina, Greece.
Stelios
S
Tigas
Department of Computer Engineering, School of Applied Technology, Technological Educational Institute of Epirus, 47100 Arta, Greece.
Alexandros T
AT
Tzallas
Department of Psychiatry, Medical School, University of Ioannina, P.O. Box 1186, 45110 Ioannina, Greece.
Ioannis
I
Papadopoulos
Department of Psychiatry, Medical School, University of Ioannina, P.O. Box 1186, 45110 Ioannina, Greece.
Petros
P
Skapinakis
Department of Psychiatry, Medical School, University of Ioannina, P.O. Box 1186, 45110 Ioannina, Greece.
Venetsanos
V
Mavreas
D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005215:Fasting / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006706:Homeostasis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D011618:Psychotic Disorders / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002096:C-Peptide; D002784:Cholesterol; D006442:Glycated Hemoglobin; D006854:Hydrocortisone; D007328:Insulin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human
Cholesterol; Diabetes; Dyslipidemia; First-episode; Metabolism; Schizophrenia