A retrospective study of 23 cases with subacute combined degeneration.
OBJECTIVE
To study retrospectively the diverse presentations, ancillary tests and neuroimaging in patients with subacute combined degeneration (SCD).


METHODS
Twenty-three Chinese patients with SCD were included in this study. The clinical presentations and laboratory data including comprehensive metabolic panel, serum folic acid, vitamin B12 levels, gastroscopy and images of spinal cord on magnetic resonance imaging (MRI) were evaluated. Rating scales for localizations of lesions and functional disabilities were used to define the severity of neurological impairment.


RESULTS
No difference was found between men and women in the age of disease onset. For most of the patients, sensory symptoms, oftentimes as initial symptoms, occurred earlier than motor symptoms. The signs of the disease were more obvious than the symptoms. Six patients had sensory deficit levels mimicking transverse myelopathy. Anemia was not always detected in our patients with SCD. Normal or even elevated serum levels of vitamin B12 were found in seven patients. Spinal cord lesions on MRI were observed in six patients and the clinical and neuroimaging findings were not necessarily consistent.


CONCLUSIONS
The sensory symptoms occur earlier than the motor symptoms in SCD patients. SCD patients may have sensory deficit level. Normal or even elevated serum levels of vitamin B12 may occur in patients with SCD.
a Department of Neurology.
Jiasi
J
Li
c Department of Neurology , The Affiliated Hospital of Weifang Medical University , Weifang City , China.|d Department of Neurological Disorder , Case Medical Center , Cleveland , OH , USA.
Ming
M
Ren
b Department of Nuclear Medicine , Changhai Hospital , Shanghai , China.
Aisheng
A
Dong
e Department of Neurology , Shanghai First People's Hospital , Shanghai , China.
Yuncheng
Y
Wu
a Department of Neurology.
Ning
N
Han
a Department of Neurology.
Benqiang
B
Deng
a Department of Neurology.
Xiaoying
X
Bi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D052879:Subacute Combined Degeneration / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D014805:Vitamin B 12 / Q000097:blood*
D014805:Vitamin B 12
clinical features; hemoglobin; sensory deficit level; subacute combined degeneration; vitamin B12