A 4-week study of four 3-monochloropropane-1,2-diol diesters on lipid metabolism in C57BL/6J mice.
3-Monochloropropane-1,2-diol (3-MCPD) esters have been detected in many foods, which have become a new safety issue worldwide. In the study, we investigated the effect of four 3-MCPD diesters (palmitate diester: CDP; stearate diester: CDS; oleate diester: CDO; linoleate diester: CDL) on lipid metabolism in C57BL/6J mice. The results showed that CDP, CDS, CDO and CDL significantly increased the serum TC, LDL-C levels and liver TG, TC levels at dose of 16.5μmol/kg/day. These results indicated that 3-MCPD diesters could potentially cause hyperlipidemia in C57BL/6J mice. Moreover, oil red O staining confirmed fat accumulation in liver induced by 3-MCPD diesters. Our work will provide more information for safety evaluation of 3-MCPD diesters. However, whether free 3-MCPD or free fatty acids or combined action compensates for the hyperlipidemia effects should be elucidated in the future.
Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Jing
J
Lu
Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Zhenning
Z
Wang
Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Mengrou
M
Ren
Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Guangxin
G
Feng
Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Beining
B
Ye
Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Yi
Y
Wang
Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Baochen
B
Fang
Key Laboratory of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Xuming
X
Deng
Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China. Electronic address: gshuang1973@126.com.
Shuang
S
Guan
D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006949:Hyperlipidemias / Q000209:etiology; D019787:Linoleic Acid / Q000008:administration & dosage / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019301:Oleic Acid / Q000008:administration & dosage / Q000494:pharmacology; D010168:Palmitates / Q000008:administration & dosage / Q000494:pharmacology; D000517:alpha-Chlorohydrin / Q000008:administration & dosage* / Q000494:pharmacology
D015415:Biomarkers; D008055:Lipids; D010168:Palmitates; D019301:Oleic Acid; D000517:alpha-Chlorohydrin; D019787:Linoleic Acid
3-MCPD diesters; C57BL/6J mice; Hyperlipidemia; In vivo