Angiotensin-(1-7): beyond its central effects on blood pressure.
Angiotensin (Ang) (1-7) is the main component of the depressor and protective arm of the renin-angiotensin system. Ang-(1-7) induces vasodilation, natriuresis and diuresis, cardioprotection, inhibits angiogenesis and cell growth and opposes the pressor, proliferative, profibrotic, and prothrombotic actions mediated by Ang II. Centrally, Ang-(1-7) induces changes in mean arterial pressure and this effect may be linked with its inhibitory neuromodulatory action on norepinephrine neurotransmission. The present review is focused on the role of Ang-(1-7) as a protective agent in the brain.
Departamento de Química Biológica, IQUIFIB-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Ciudad Autónoma de Buenos Aires, Argentina mariela@qb.ffyb.uba.ar.
Mariela M
MM
Gironacci
D000803:Angiotensin I / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000502:physiology*; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism*; D010446:Peptide Fragments / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology
D010446:Peptide Fragments; D000803:Angiotensin I; C118790:angiotensin I (1-7); D009638:Norepinephrine
Mas receptor; angiogenesis; angiotensin-(1–7); norepinephrine; stroke