[Serious infection due to biologicals: risk only mildly elevated in patients with rheumatoid arthritis].
Biologicals are often thought to increase the risk of infection. A recent review shows that the risk of serious infection in patients with rheumatoid arthritis being treated with biologicals (standard dose) is only mildly elevated compared with those who are treated with conventional DMARDs only (odds ratio: 1.3). If biologicals are used at a lower dosage, e.g. tapering studies, the risk of serious infection does not seem to be increased. Alertness for infection in these patients, dose tapering and preventive measures such as vaccination, patient education and tuberculosis screening may potentially further reduce this serious side effect of biologicals.
Sint Maartenskliniek, afd. Reumatologie, Nijmegen.
Alfons A
AA
den Broeder
Henk J
HJ
Schers
D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D001688:Biological Products / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D003141:Communicable Diseases / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D016017:Odds Ratio; D012307:Risk Factors
D018501:Antirheumatic Agents; D001688:Biological Products