Spontaneous formation and amplification of an enantioenriched α-amino nitrile: a chiral precursor for Strecker amino acid synthesis.
Without the addition of any chiral substances, the spontaneous formation of an enantioenriched α-amino nitrile (up to 96% ee), which is a chiral precursor for Strecker amino acid synthesis, has been achieved in combination with conglomerate formation. The frequency of the formation of enantiomorphs exhibits an approximate stochastic distribution, i.e., L-form occurred 21 times and D-form occurred 22 times, which fulfils the conditions necessary for spontaneous absolute asymmetric synthesis.
Department of Materials Science and Engineering, University of Fukui, Bunkyo, Fukui, 910-8507 Japan. tk@u-fukui.ac.jp.
Tsuneomi
T
Kawasaki
Naoya
N
Takamatsu
Shohei
S
Aiba
Yuji
Y
Tokunaga
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques; D013237:Stereoisomerism; D013269:Stochastic Processes
D000596:Amino Acids; D009570:Nitriles