STING Signaling the enERGIC Way.
The effector proteins IpaJ and VirA, from the bacterium Shigella flexneri, block the general secretory pathway (GSP) at different stages. In this issue of Cell Host & Microbe, Dobbs et al. (2015) use these proteins as a tool to pinpoint STING trafficking and signaling to the ER-Golgi intermediate compartment (ERGIC).
Institute of Molecular Medicine, University Hospital, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
Björn
B
Hiller
Institute of Molecular Medicine, University Hospital, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany. Electronic address: veit.hornung@uni-bonn.de.
Veit
V
Hornung
D000818:Animals; D054884:Host-Pathogen Interactions; D008565:Membrane Proteins / Q000378:metabolism*; D012760:Shigella / Q000276:immunology* / Q000502:physiology*; D015533:Transcriptional Activation
D008565:Membrane Proteins