Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems.
Recent developments in nanotechnology and application of magnetic nanoparticles, in particular in magnetic iron oxide nanosystems, offer exciting possibilities for nanomedicine. Facile and precise synthesis procedures, high magnetic response, tunable morphologies and multiple bio-functionalities of single- and multi-core magnetic particles designed for nanomedicine applications are thoroughly appraised. This review focuses on the structural and magnetic characterization of the cores, the synthesis of single- and multicore iron oxide NPs, especially the design of the latter, as well as their protection, stabilization and functionalization by desired coating in order to protect against the corrosion of core, to prevent non-specific protein adsorption and particle aggregation in biological media, and to provide binding sites for targeting and therapeutic agents.
Department of Physical Chemistry and Materials Science, University of Szeged, Aradi Vt. 1, H-6720 Szeged, Hungary.
Etelka
E
Tombácz
National Institute R&D for Isotopic and Molecular Technologies, 67-103 Donat Str., RO-400293 Cluj-Napoca, Romania.
Rodica
R
Turcu
Romanian Academy-Timisoara Branch, Center for Fundamental and Advanced Technical Research, Lab. Magnetic Fluids, 24 M. Viteazu Ave., RO-300223 Timisoara, Romania.
Vlad
V
Socoliuc
Romanian Academy-Timisoara Branch, Center for Fundamental and Advanced Technical Research, Lab. Magnetic Fluids, 24 M. Viteazu Ave., RO-300223 Timisoara, Romania. Electronic address: vekas.ladislau@gmail.com.
Ladislau
L
Vékás
D003287:Contrast Media / Q000138:chemical synthesis*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000528:radiation effects; D015195:Drug Design; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D053769:Nanocapsules / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D000068936:Theranostic Nanomedicine / Q000379:methods
D003287:Contrast Media; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D053769:Nanocapsules
Functional coatings; Iron oxide nanoparticles; Multi-core magnetic particles; Nanomedicine applications; Single core magnetic particles; Synthesis procedures