Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases.
Lung disease is the major cause of death and hospitalization worldwide. Transcription factors such as transcription factor 7 (TCF7) are involved in the pathogenesis of lung diseases. TCF7 is important for T cell development and differentiation, embryonic development, or tumorogenesis. Multiple TCF7 isoforms can be characterized by the full-length isoform (FL-TCF7) as a transcription activator, or dominant negative isoform (dn-TCF7) as a transcription repressor. TCF7 interacts with multiple proteins or target genes and participates in several signal pathways critical for lung diseases. TCF7 is involved in pulmonary infection, allergy or asthma through promoting T cells differentiating to Th2 or memory T cells. TCF7 also works in tissue repair and remodeling after acute lung injury. The dual roles of TCF7 in lung cancers were discussed and it is associated with the cellular proliferation, invasion or metastasis. Thus, TCF7 plays critical roles in lung diseases and should be considered as a new therapeutic target.
Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University Center for Clinical Bioinformatics, Fenglin Rd 180, Shanghai, 200032, China. zhu.yichun@zs-hospital.sh.cn.
Yichun
Y
Zhu
Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University Center for Clinical Bioinformatics, Fenglin Rd 180, Shanghai, 200032, China. william_95a@hotmail.com.
William
W
Wang
Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University Center for Clinical Bioinformatics, Fenglin Rd 180, Shanghai, 200032, China. xiangdong.wang@clintransmed.com.
Xiangdong
X
Wang
D055371:Acute Lung Injury / Q000378:metabolism; D000818:Animals; D017252:CD3 Complex / Q000378:metabolism; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D005799:Genes, Dominant; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D020381:Interleukin-17 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008171:Lung Diseases / Q000276:immunology*; D008175:Lung Neoplasms / Q000378:metabolism; D051821:Lymphoid Enhancer-Binding Factor 1 / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D020033:Protein Isoforms / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D051822:T Cell Transcription Factor 1 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology; D018418:Th2 Cells / Q000166:cytology; D051176:beta Catenin / Q000378:metabolism
D017252:CD3 Complex; C115335:CD3E protein, human; D020381:Interleukin-17; C497573:LEF1 protein, human; D051821:Lymphoid Enhancer-Binding Factor 1; D020033:Protein Isoforms; D051880:Receptors, Notch; D051822:T Cell Transcription Factor 1; C497576:TCF7 protein, human; D051176:beta Catenin; D015847:Interleukin-4