Research Progress on Regulatory T Cells in Acute Kidney Injury.
Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate injury in several murine experimental models of renal inflammation. Recent studies have illuminated the renal-protective function of Tregs in AKI. Tregs appear to exert beneficial effects in both the acute injury phase and the recovery phase of AKI. Additionally, Tregs-based immunotherapy may represent a promising approach to ameliorate AKI and promote recovery from AKI. This review will highlight the recent insights into the role of Tregs and their therapeutic potential in AKI.
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China ; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
Yamei
Y
Wang
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Yuhong
Y
Tao
D058186:Acute Kidney Injury / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D000818:Animals; D006801:Humans; D056747:Immunomodulation; D007167:Immunotherapy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism