Effect of Yoga Practice on Levels of Inflammatory Markers After Moderate and Strenuous Exercise.
OBJECTIVE
To evaluate the effect of yoga practice and exercise challenge on Tumour Necrosis Factor alpha (TNF-α), Interleukin-6 (IL-6) levels and lipid profile.


METHODS
Two hundred and eighteen subjects participated in the study. One hundred and nine volunteers (51 males and 58 females) in the age group of 20 to 60 years, who practiced yoga regularly for over five years for a period of one hour daily, performed a bout of moderate exercise and a bout of strenuous exercise as per Standardized Shuttle Walk test protocol. Anthropometrically matched, age matched and gender matched subjects, who did not practice yoga (non-yoga group) were chosen as controls (non-yoga, n=109). The non-yoga group also performed similar exercises. The blood samples of both the groups were collected before and after the exercises. TNF-α and IL-6 was analysed before and after the exercise by Sandwich ELISA (Enzyme Linked Immunosorbent Assay).


RESULTS
Resting plasma TNF-α concentration was significantly higher in non-yoga group when compared to yoga group (p<0.05). There was an increase in TNF-α levels in both the groups in response to strenuous exercise. There was no gender difference in TNF-α and IL-6 levels before and after exercise in yoga and non-yoga groups.


CONCLUSIONS
Regular practice of yoga lowers basal TNF-α and IL-6 levels. It also reduces the extent of increase of TNF-α and IL-6 to a physical challenge of moderate exercise and strenuous exercise. There is no significant gender difference in the TNF-α and IL-6 levels. Regular practice of yoga can protect the individual against inflammatory diseases by favourably altering pro-inflammatory cytokine levels.
Associate Professor, Department of Physiology, M. S. Ramaiah Medical College , Bangalore, India .
Ambarish
A
Vijayaraghava
Professor, Department of Physiology, M. S. Ramaiah Medical College , Bangalore, India .
Venkatesh
V
Doreswamy
Chief Research Scientist, Yoga and Biomech Lab, Department of Aerospace Engineering, Indian Institute of Science , Bangalore, India .
Omkar Subbaramajois
OS
Narasipur
Lecturer Cum Statistician, Department of Preventive and Social Medicine, M. S. Ramaiah Medical College , Bangalore, India .
Radhika
R
Kunnavil
Professor Cum Statistician and Research Co-Ordinator, Department of Preventive and Social Medicine, M. S. Ramaiah Medical College , Bangalore, India .
Nandagudi
N
Srinivasamurthy
Inflammation; Interleukin-6; Shuttle walk test; Tumour Necrosis Factor-α