Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men.
Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1 → 3)(1 → 6) glucan, a well-known immunostimulant and antioxidant compound. In this experimental, randomized and placebo-controlled study, the effects of oral CM-G intake over a 60-day period on the peripheral blood, cholesterol, glycemic index and malondialdehyde (MDA) levels of healthy men was assessed. The CM-G was obtained from spent brewer's yeast (S. uvarum) with DS 0.8 and molecular weight of 2.2 × 10(5) Da. Following CM-G administration, no changes were observed in red and white blood cell, hematocrit, hemoglobin and platelet counts, or in cholesterol and glycemic indices. After 30 days of CM-G administration, the MDA levels decreased significantly (p ≤ 0.05) in men receiving CM-G. The results showed for the first time that CM-G may act as an adjuvant in preventing oxidative damage in healthy humans.
Laboratório de Bioquímica de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil. vilmaengenheira2@gmail.com.
Vilma Barbosa da Silva
VB
Araújo
Laboratório de Bioquímica de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil.
Adma Nadja Ferreira
AN
de Melo
Laboratório de Bioquímica de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil.
Neyrijane Targino
NT
de Souza
Laboratório de Bioquímica de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil.
Vânia Maria Barboza
VM
da Silva
Departamento de Ciência e Tecnologia de Alimentos, Universidade Estadual de Londrina, Paraná 8606970, Brazil. rcastrog@yahoo.com.
Raul H
RH
Castro-Gomez
Departamento de Educação, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil. ass974@yahoo.com.br.
Alexandre Sérgio
AS
Silva
Laboratório de Microbiologia de Alimentos, Departmento de Nutrição, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil. evandroleitesouza@pq.cnpq.br.
Evandro Leite
EL
de Souza
Laboratório de Bioquímica de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil. magnani2@gmail.com.
Marciane
M
Magnani
D000284:Administration, Oral; D000328:Adult; D002452:Cell Count; D006262:Health; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D012440:Saccharomyces / Q000737:chemistry*; D047071:beta-Glucans / Q000008:administration & dosage* / Q000494:pharmacology*
D047071:beta-Glucans; D008315:Malondialdehyde; C029933:carboxymethyl-beta-1,3-glucan
blood cells; carboxymethyl-glucan; glucan-derivatives; malondialdehyde