Ovarian stimulation for oocyte cryopreservation for prevention of age-related fertility loss: one in five is a low responder.
Oocyte cryopreservation for age-related fertility loss is gaining interest considering the tendency to postpone motherhood in many societies. Little is currently known about the actual efficiency of this approach. We aimed to explore ovarian response of presumably fertile women undergoing in vitro fertilization for this indication. A total of 105 women underwent 151 stimulation cycles at mean age 37.7 ± 2.4. None had known infertility. Mean daily starting FSH dose was 371 ± 110 (225-600). Mean number of mature oocytes cryopreserved at the first completed cycle was 9.7 ± 7.5 (0-43). However, 21% of started cycles were either cancelled before egg retrieval or resulted in 0-3 mature oocytes retrieved. Therefore, women considering oocyte cryopreservation for prevention of age-related fertility decline should be encouraged to perform this procedure at younger age than, preferably before 35.
a Shaare-Zedek, IVF Unit, Department of Obstetrics and Gynecology , Affiliated with the Hebrew University School of Medicine , Jerusalem , Israel and.
Avi
A
Tsafrir
b IVF Unit, Department of Obstetrics and Gynecology , Hadassah Hebrew University Medical Center , Mt Scopus , Jerusalem , Israel.
Ronit
R
Haimov-Kochman
a Shaare-Zedek, IVF Unit, Department of Obstetrics and Gynecology , Affiliated with the Hebrew University School of Medicine , Jerusalem , Israel and.
Ehud J
EJ
Margalioth
a Shaare-Zedek, IVF Unit, Department of Obstetrics and Gynecology , Affiliated with the Hebrew University School of Medicine , Jerusalem , Israel and.
Talia
T
Eldar-Geva
a Shaare-Zedek, IVF Unit, Department of Obstetrics and Gynecology , Affiliated with the Hebrew University School of Medicine , Jerusalem , Israel and.
Michael
M
Gal
b IVF Unit, Department of Obstetrics and Gynecology , Hadassah Hebrew University Medical Center , Mt Scopus , Jerusalem , Israel.
Yuval
Y
Bdolah
b IVF Unit, Department of Obstetrics and Gynecology , Hadassah Hebrew University Medical Center , Mt Scopus , Jerusalem , Israel.
Tal
T
Imbar
b IVF Unit, Department of Obstetrics and Gynecology , Hadassah Hebrew University Medical Center , Mt Scopus , Jerusalem , Israel.
Arye
A
Hurwitz
a Shaare-Zedek, IVF Unit, Department of Obstetrics and Gynecology , Affiliated with the Hebrew University School of Medicine , Jerusalem , Israel and.
Avraham
A
Ben-Chetrit
a Shaare-Zedek, IVF Unit, Department of Obstetrics and Gynecology , Affiliated with the Hebrew University School of Medicine , Jerusalem , Israel and.
Doron
D
Goldberg
D000328:Adult; D015925:Cryopreservation; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control*; D054315:Oocyte Retrieval; D009865:Oocytes / Q000166:cytology*; D010062:Ovulation Induction / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
D005640:Follicle Stimulating Hormone
Age-related infertility; controlled ovarian stimulation; oocyte cryopreservation; social egg freezing