Electromyographic Manifestations of Fatigue Correlate With Pulmonary Function, 6-Minute Walk Test, and Time to Exhaustion in COPD.
BACKGROUND
The aim of this study was to investigate whether electromyographic manifestations of fatigue and exercise tolerance were related to stage of disease in men with a COPD diagnosis.


METHODS
Fourteen men with COPD with a diagnosis of mild to severe air flow obstruction were involved in 2 separate testing sessions. The first one consisted of a pulmonary function (FEV1 and FEV1/FVC) and an exercise tolerance assessment using the 6-min walk test. During the second session, a multichannel surface electromyography was recorded from vastus medialis and vastus lateralis muscles during an isometric knee extension at 70% of maximum voluntary contraction. The slope of muscle fiber conduction velocity during the contraction was calculated as the index of fatigue.


RESULTS
Conduction velocity slope significantly correlated with FEV1 (vastus medialis: r = 0.86, P < .001; vastus lateralis: r = 0.68, P = .01), FEV1/FVC (vastus medialis: r = 0.70, P = .006), and 6-min walk test (vastus medialis: r = 0.72, P = .005; vastus lateralis: r = 0.80, P = .001).


CONCLUSIONS
The electromyographic manifestations of fatigue during sustained quadriceps contraction significantly correlated with disease severity and exercise tolerance in moderate to severe COPD.
Motor Science Research Center, School of Exercise and Sport Sciences, SUISM, Department of Medical Sciences, University of Turin, 12, Piazza Bernini, Torino, Italy. CeRiSM Research Center "Sport, Mountain, and Health," Via del Ben 5/b, Rovereto, Italy.
Gennaro
G
Boccia
Motor Science Research Center, School of Exercise and Sport Sciences, SUISM, Department of Medical Sciences, University of Turin, 12, Piazza Bernini, Torino, Italy.
Davide
D
Dardanello
Department of Neurological and Movement Sciences, University of Verona, Via Casorati 43, Verona, Italy.
Nicoletta
N
Rinaldo
Department of Neurological and Movement Sciences, University of Verona, Via Casorati 43, Verona, Italy.
Giuseppe
G
Coratella
Department of Neurological and Movement Sciences, University of Verona, Via Casorati 43, Verona, Italy. CeRiSM Research Center "Sport, Mountain, and Health," Via del Ben 5/b, Rovereto, Italy.
Federico
F
Schena
Motor Science Research Center, School of Exercise and Sport Sciences, SUISM, Department of Medical Sciences, University of Turin, 12, Piazza Bernini, Torino, Italy. alberto.rainoldi@unito.it.
Alberto
A
Rainoldi
D000368:Aged; D004576:Electromyography; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012123:Pulmonary Ventilation / Q000502:physiology*; D052097:Quadriceps Muscle / Q000503:physiopathology; D013997:Time Factors; D016138:Walking
6-minute walk test; COPD; electromyography; muscle endurance; neuromuscular fatigue; vastus lateralis; vastus medialis