Oral manifestations of Systemic Sclerosis and Correlation with anti-Topoisomerase I Antibodies (SCL-70).
BACKGROUND
Progressive systemic sclerosis (PSS) is a chronic autoimmune illness. Clinical oral manifestations in Scleroderma are very frequent.


OBJECTIVE
To explore the oral manifestations, frequent and rare, to investigate whether there are differences between gender and the observed correlation of changes in relation to Antibodies Anti-Topoisomerase I.


METHODS
in the study were included 75 patients (65 females and 10 males), their mean age was 45.2±10, duration of illness was around 5.1±12 years diagnosed according to the ACR criteria and treated in the period 2010-2013.


RESULTS
98.7% of our patients were ANA positive, whereas 49.3% of them were Anti SCL-70 positive. Patients in 91% of cases had one or more oral manifestations of disease. The most frequent oral manifestations are: small mouth (n = 39), the lingua short frenulum (n = 21), Xerostomia (n = 24) and paradontopathia (n = 16), while more rare are: Telangiectasia (n = 14), decreased interincisal distance (n = 9), missing teeth (n = 9), absorption of dental alveoli (n = 5) and Neuralgia n. trigeminus (n = 3). Oral symptoms have been frequent in patients with Scleroderma, SCL -70 positive but not statistically significant difference.


CONCLUSIONS
Oral changes have high frequency in patients with Scleroderma and these changes provide high discomfort of the mouth and lower quality of life. Oral health care to patients with Scleroderma is very important and it affects a lot in reducing the level of disease and increase the quality of life.
Clinic of Rheumatology, University Clinical Centre of Kosovo, Prishtina, Kosovo.
Ismet H
IH
Bajraktari
Clinic of Rheumatology, University Clinical Centre of Kosovo, Prishtina, Kosovo.
Avni
A
Kryeziu
Clinic of Gastroenterology, University Clinical Centre of Kosovo, Prishtina, Kosovo.
Fadil
F
Sherifi
Ambulance for Internal Medicine and Rheumatology, "Promedica", Prishtina, Kosovo.
Halit
H
Bajraktari
Clinic of Rheumatology, University Clinical Centre of Kosovo, Prishtina, Kosovo.
Ali
A
Lahu
Nacional Institute for Public Health of Kosovo, Prishtina, Kosovo.
Genc
G
Bajraktari
D000974:Antibodies, Antinuclear / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology* / Q000276:immunology; D011446:Prospective Studies; D012595:Scleroderma, Systemic / Q000150:complications / Q000276:immunology / Q000473:pathology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D004264:DNA Topoisomerases, Type I
Oral manifestations; Progressive systemic sclerosis; Small mouth and Anti SCL-70