Cyclophilin polymorphism and virus infection.
Viruses are obligate intracellular parasites. All stages of their replication cycle depend on support by host-encoded factors. However, sequence variation also exists in host factors mostly in the form of single nucleotide polymorphisms (SNPs). Several coding and non-coding genetic variants in the PPIA gene encoding for CypA have been described, but there is only limited information about their influence on the course of viral infection. This paper reviews PPIA polymorphisms and what is known about their impact on the replication cycle and course of disease for different viral infections.
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany; German Center for Infection Research (DZIF), Germany; Institute for Molecular Biology, Medizinische Hochschule Hannover, Hannover, Germany.
Thomas
T
von Hahn
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany; German Center for Infection Research (DZIF), Germany. Electronic address: Ciesek.sandra@mh-hannover.de.
Sandra
S
Ciesek
D021984:Cyclophilin A / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D011110:Polymorphism, Genetic; D014777:Virus Diseases / Q000235:genetics* / Q000276:immunology*
D021984:Cyclophilin A