Sympathetic arousal increases a negative memory bias in young women with low sex hormone levels.
Emotionally arousing events are typically better attended to and remembered than neutral ones. Current theories propose that arousal-induced increases in norepinephrine during encoding bias attention and memory in favor of affectively salient stimuli. Here, we tested this hypothesis by manipulating levels of physiological arousal prior to encoding and examining how it influenced memory for emotionally salient images, particularly those that are negative rather than positive in valence. We also tested whether sex steroid hormones interact with noradrenergic activity to influence these emotional memory biases in women. Healthy naturally cycling women and women on hormonal contraception completed one of the following physiological arousal manipulations prior to viewing a series of negative, positive and neutral images: (1) immediate handgrip arousal-isometric handgrip immediately prior to encoding, (2) residual handgrip arousal-isometric handgrip 15min prior to encoding, or (3) no handgrip. Sympathetic arousal was measured throughout the session via pupil diameter changes. Levels of 17β-estradiol and progesterone were measured via salivary samples. Memory performance was assessed approximately 10min after encoding using a surprise free recall test. The results indicated that handgrip successfully increased sympathetic arousal compared to the control task. Under immediate handgrip arousal, women showed enhanced memory for negative images over positive images; this pattern was not observed in women assigned to the residual and no-handgrip arousal conditions. Additionally, under immediate handgrip arousal, both high estradiol and progesterone levels attenuated the memory bias for negative over positive images. Follow-up hierarchical linear models revealed consistent effects when accounting for trial-by-trial variability in normative International Affective Picture System valence and arousal ratings. These findings suggest that heightened sympathetic arousal interacts with estradiol and progesterone levels during encoding to increase the mnemonic advantage of negative over positive emotional material.
University of Southern California, Davis School of Gerontology, Los Angeles, CA 90089, USA. Electronic address: senielse@usc.edu.
Shawn E
SE
Nielsen
San Francisco State University, Psychology Department, San Francisco, CA 94132, USA.
Sarah J
SJ
Barber
University of Southern California, Davis School of Gerontology, Los Angeles, CA 90089, USA.
Audrey
A
Chai
University of Southern California, Neuroscience Graduate Program, Los Angeles, CA 90089, USA.
David V
DV
Clewett
University of Southern California, Davis School of Gerontology, Los Angeles, CA 90089, USA; University of Southern California, Psychology Department, Los Angeles, CA 90089, USA; University of Southern California, Neuroscience Graduate Program, Los Angeles, CA 90089, USA.
Mara
M
Mather
D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D004958:Estradiol / Q000032:analysis; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D008568:Memory / Q000502:physiology*; D008597:Menstrual Cycle / Q000502:physiology; D009483:Neuropsychological Tests; D011374:Progesterone / Q000032:analysis; D012463:Saliva / Q000737:chemistry; D055815:Young Adult
D011374:Progesterone; D004958:Estradiol
BANE; Emotional memory; GANE; Hormones; Pupil dilation; Sympathetic arousal