Association of the Trp316Ser variant (rs1801690) near the apolipoprotein H (β2-glycoprotein-I) gene and serum lipid levels.
The objective of the present study was to detect the association of the Trp316Ser variant (rs1801690) near the apolipoprotein H (β2-glycoprotein-I) gene and serum lipid levels in the Mulao and Han populations. A total of 879 subjects of Mulao and 844 subjects of Han Chinese were included. The levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and ApoA1 in Mulao, and triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), ApoA1 and the ratio of ApoA1/ApoB in Han were different among the three genotypes of the rs1801690 SNP (P < 0.05-0.01). Subgroup analyses showed that the levels of TC, TG, LDL-C, and ApoA1 in Mulao males; ApoA1 in Mulao females; TC, TG, HDL-C and ApoB and the ApoA1/ApoB ratio in Han males; and HDL-C, ApoA1 and the ApoA1/ApoB ratio in Han females were associated with the genotypes of rs1801690 (P < 0.05-0.001). Serum lipid parameters were also associated with several environmental factors (P < 0.05-0.001). The Trp316Ser variant (rs1801690) near the apolipoprotein H (β2-glycoprotein-I) gene was associated with some serum lipid parameters in the two ethnic groups, but the trends of association suggest that the Trp316Ser variant (rs1801690) near the apolipoprotein H (β2-glycoprotein-I) gene might have racial/ethnic-and/or gender-specificity.
Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University Nanning 530021, Guangxi, China.
Tao
T
Guo
Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University Nanning 530021, Guangxi, China.
Rui-Xing
RX
Yin
Clinical Laboratory of The Affiliated Cancer Hospital, Guangxi Medical University Nanning 530021, Guangxi, People's Republic of China.
Hui
H
Li
Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
Yi-Ming
YM
Wang
Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University Nanning 530021, Guangxi, China.
Jin-Zhen
JZ
Wu
Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
De-Zhai
DZ
Yang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D055815:Young Adult; D053482:beta 2-Glycoprotein I / Q000235:genetics*
D015415:Biomarkers; D008055:Lipids; D053482:beta 2-Glycoprotein I
Lipids; apolipoprotein H; environmental factor; the Trp316Ser variant; β2-glycoprotein-I