Psammomatous melanotic schwannoma as a component of Carney complex.
Melanotic schwannoma is a rare form of pigmented neural tumor commonly arising from the posterior spinal nerves and ganglia. Two variants have been described, psammomatous and nonpsammomatous. 50% of psammomatous tumors are associated with Carney complex. The biologic behavior of the tumor is difficult to predict and slightly over 10% of the tumors follow malignant course. We present a case of psammomatous melanotic schwannoma as part of Carney complex in a 67-year-old male. Clinical examination revealed oral mucosal and abdominal skin pigmentation. Magnetic resonance imaging showed an intradural extramedullary lesion at D8-D12 level. Intraoperative squash smear study showed sheets of spindle cells with abundant intracytoplasmic melanin pigmentation and few psammoma bodies. Based on clinical, radiologic, and histopathological findings with immunohistochemistry correlation a final diagnosis of psammomatous melanotic schwannoma was rendered.
Department of Histopathology, SRM Institute for Medical Sciences, Chennai, Tamil Nadu, India.
Salapathi
S
Shanmugam
Mitra
M
Ghosh
Sadiya
S
Niamathullah
Siddhartha
S
Ghosh
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D056733:Carney Complex / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D006257:Head / Q000000981:diagnostic imaging; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008543:Melanins / Q000032:analysis*; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology*; D008853:Microscopy; D009061:Mouth Mucosa / Q000473:pathology; D009442:Neurilemmoma / Q000175:diagnosis* / Q000473:pathology*; D011859:Radiography; D012867:Skin / Q000473:pathology; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000473:pathology
D014408:Biomarkers, Tumor; D008543:Melanins