Unbiased estimation for response adaptive clinical trials.
Bayesian adaptive trials have the defining feature that the probability of randomization to a particular treatment arm can change as information becomes available as to its true worth. However, there is still a general reluctance to implement such designs in many clinical settings. One area of concern is that their frequentist operating characteristics are poor or, at least, poorly understood. We investigate the bias induced in the maximum likelihood estimate of a response probability parameter, p, for binary outcome by the process of adaptive randomization. We discover that it is small in magnitude and, under mild assumptions, can only be negative - causing one's estimate to be closer to zero on average than the truth. A simple unbiased estimator for p is obtained, but it is shown to have a large mean squared error. Two approaches are therefore explored to improve its precision based on inverse probability weighting and Rao-Blackwellization. We illustrate these estimation strategies using two well-known designs from the literature.
1 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.|2 MRC Biostatistics Unit, Cambridge, UK.
Jack
J
Bowden
3 Dana-Farber Cancer Institute, Boston, USA.
Lorenzo
L
Trippa
D000075522:Adaptive Clinical Trials as Topic / Q000379:methods*; D001499:Bayes Theorem; D015982:Bias; D003627:Data Interpretation, Statistical; D006801:Humans; D016013:Likelihood Functions; D011336:Probability
Clinical trial; Horvitz-Thompson estimator; Rao-Blackwellization; adaptive randomization; bias adjusted estimation; inverse probability weighting