[Vitex Agnus Castus in the treatment of hyperprolactinemia and menstrual disorders - a case report].
We describe a patient with mild hyperprolactinemia and menstrual disorders (oligomenorrhea). She presented relative hypoestrogenism in laboratory tests. Magnetic resonans excluded the presence of pituitary adenoma. Because patient developed a bromocriptine intolerance, the Vitex Agnus Castus (VAC) extract has been introduced. The VAC therapy was effective, with symptoms relief and improvement of hormonal tests. The VAC medicines are indicated for the treatment of premenstrual syndrome (PMS), mastalgia, menstrual disorders and mild hyperprolactinemia. The mechanism of action is not fully understood, but it is related to dopaniergic activity of diterpenes and castacin in VAC. The randomized clinical trials revealed efficacy of VAC extract in the treatmet of hyperprolactinemia, menstrual disorders, PMS and mastalgia. Good tolerability, lack of serious side-effects and drug interactions are the advantages of the VAC preparations.
Department of Gynecological Endocrinology, Medical University of Poznan, Poland.
Błażej
B
Męczekalski
Department of Gynecological Endocrinology, Medical University of Poznan, Poland.
Adam
A
Czyżyk
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications / Q000188:drug therapy*; D009839:Oligomenorrhea / Q000150:complications / Q000188:drug therapy*; D011293:Premenstrual Syndrome / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome; D020950:Vitex
D004365:Drugs, Chinese Herbal; C553090:Vitex agnus castus extract
Vitex Agnus Castus; hyperprolactinemia; menstrual disorders