Facile Fabrication of Lubricant-Infused Wrinkling Surface for Preventing Thrombus Formation and Infection.
Despite the advanced modern biotechniques, thrombosis and bacterial infection of biomedical devices remain common complications that are associated with morbidity and mortality. Most antifouling surfaces are in solid form and cannot simultaneously fulfill the requirements for antithrombosis and antibacterial efficacy. In this work, we present a facile strategy to fabricate a slippery surface. This surface is created by combining photografting polymerization with osmotically driven wrinkling that can generate a coarse morphology, and followed by infusing with fluorocarbon liquid. The lubricant-infused wrinkling slippery surface can greatly prevent protein attachment, reduce platelet adhesion, and suppress thrombus formation in vitro. Furthermore, E. coli and S. aureus attachment on the slippery surfaces is reduced by ∼98.8% and ∼96.9% after 24 h incubation, relative to poly(styrene-b-isobutylene-b-styrene) (SIBS) references. This slippery surface is biocompatible and has no toxicity to L929 cells. This surface-coating strategy that effectively reduces thrombosis and the incidence of infection will greatly decrease healthcare costs.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.|University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Shuaishuai
S
Yuan
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
Shifang
S
Luan
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.|University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Shunjie
S
Yan
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
Hengchong
H
Shi
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
Jinghua
J
Yin
D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D001777:Blood Coagulation; D002460:Cell Line; D004926:Escherichia coli / Q000187:drug effects / Q000648:ultrastructure; D016650:Fluorescein-5-isothiocyanate / Q000378:metabolism; D054327:Lubricants / Q000494:pharmacology*; D008422:Materials Testing; D051379:Mice; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects / Q000648:ultrastructure; D013499:Surface Properties; D013927:Thrombosis / Q000473:pathology / Q000517:prevention & control*
D054327:Lubricants; D016650:Fluorescein-5-isothiocyanate
antibacterial; antifouling; photografting polymerization; poly(styrene-b-isobutylene-b-styrene) (SIBS); slippery surface