Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?
The lung is relatively sensitive to irradiation. It is shown that acetylsalicylic acid (ASA) might reduce oxidative injury and that it has a place in protection from cancer. The aim of this study is to evaluate the potential radioprotective effects of ASA. Whole-body irradiation (6 Gy, single dose) was applied to the rats. Glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) levels in the lung tissue were measured. Control (C), Radiation (R), Radiation + ASA (R + ASA; received irradiation and 25 mg/kg of ASA intraperitoneally (i.p.)), and Radiation + Amifostine (R + WR-2721; received irradiation and 200 mg/kg of WR-2721 i.p.) groups were used. The MPO levels decreased statistically significantly in the group administered ASA. Histopathologically, a radioprotective effect of ASA was more evident in the R + ASA group. ASA is an agent which has not been used as a radioprotector in the clinic yet, and it is worth supporting with more advanced studies.
Department of Biophysics, Faculty of Medicine, Gaziantep University, 27310, Gaziantep, Turkey. cdemirel27@gmail.com.
Can
C
Demirel
Department of Radiation Oncology, Kolan International Hospital, 34000, Istanbul, Turkey.
Sevil Cagiran
SC
Kilciksiz
Department of Biophysics, Faculty of Medicine, Gaziosmanpaşa University, 60000, Tokat, Turkey.
Serkan
S
Gurgul
Department of Biophysics, Faculty of Medicine, Mersin University, 33169, Mersin, Turkey.
Nurten
N
Erdal
Department of Pathology, Izmir Atatürk Training and Research Hospital, 35000, Izmir, Turkey.
Seyran
S
Yigit
Department of Biochemistry, Faculty of Medicine, Mersin University, 33169, Mersin, Turkey.
Lulufer
L
Tamer
Department of Biochemistry, Faculty of Pharmacy, University of Trakya, 22000, Edirne, Turkey.
Lokman
L
Ayaz
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology* / Q000528:radiation effects; D009195:Peroxidase / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011837:Radiation-Protective Agents; D009569:Nitric Oxide; D008315:Malondialdehyde; D009195:Peroxidase; D005978:Glutathione; D004999:Amifostine; D001241:Aspirin
WR-2721; acetylsalicylic acid (ASA); irradiation injury; lung; myeloperoxidase