Increased peripheral vascular resistance in male patients with traumatic lower limb amputation: one piece of the cardiovascular risk puzzle.
OBJECTIVE
The increased morbidity and mortality in traumatic lower limb amputees can be explained by the development of risk factors, among which high blood pressure plays an important role. However, the possible mechanisms underlying increased blood pressure levels observed in this population remain unclear. Thus, we aimed to test the hypothesis that peripheral vascular resistance is increased at rest in patients with traumatic lower limb amputation.


METHODS
In a cross-sectional study, eight patients with traumatic unilateral lower limb amputation (amputee group) and eight healthy individuals without amputation (control group) were included. Resting blood pressure, heart rate, and forearm blood flow were recorded simultaneously and thus, forearm vascular resistance was calculated.


RESULTS
The amputee group showed higher systolic (126±2 vs. 118±5 mmHg, P<0.01), diastolic (78±2 vs. 63±3 mmHg, P<0.01), mean blood pressure (94±2 vs. 81±3 mmHg, P<0.01), and heart rate (74±5 vs. 65±8 bpm, P=0.02) compared with the control group. Despite the similar forearm blood flow response between groups, patients with traumatic lower limb amputation presented increased peripheral vascular resistance at rest compared with the control group (31.3±3.8 vs. 25.7±6.5 U, P=0.05).


CONCLUSIONS
Patients with traumatic amputation present increased peripheral vascular resistance. Our findings clarify one possible mechanism underlying the higher blood pressure levels observed in this population.
Research Unit for Cardiovascular and Exercise Physiology, Faculty of Physical Education, Federal University of Juiz de Fora, Minas Gerais, Brazil.
Marcelle
M
Paula-Ribeiro
Marília M N
MM
Garcia
Daniel G
DG
Martinez
Jorge R P
JR
Lima
Mateus C
MC
Laterza
D000328:Adult; D000671:Amputation, Surgical / Q000009:adverse effects*; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014655:Vascular Resistance