An AAA+ ATPase Clamshell Targets Transposition.
DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Chi-Lin
CL
Tsai
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Gareth J
GJ
Williams
Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA.
J Jefferson P
JJ
Perry
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: jatainer@lbl.gov.
John A
JA
Tainer
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism*; D004251:DNA Transposable Elements
D004251:DNA Transposable Elements