Synthesis and biological evaluation of new symmetric curcumin derivatives.
A series of novel curcumin bisacetamides aiming of enriching their biological activities have been synthesized. The synthesized compounds were screened for their in vitro antioxidant, anti-inflammatory and cytotoxic activities. All the compounds exhibited potent to good anti-inflammatory, antioxidant and noteworthy cytotoxic activities.
Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
Rajendran
R
Sribalan
Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
Maruthan
M
Kirubavathi
Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
Govindharaj
G
Banuppriya
Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India. Electronic address: padimini_tamilenthi@yahoo.co.in.
Vediappen
V
Padmini
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D012710:Serum Albumin, Bovine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D003603:Cytotoxins; D012710:Serum Albumin, Bovine; D003474:Curcumin
Acetamides; Anti-inflammatory; Antioxidant; Curcumin; Cytotoxicity