Resveratrol neuroprotection in stroke and traumatic CNS injury.
Resveratrol, a stilbene formed in many plants in response to various stressors, elicits multiple beneficial effects in vertebrates. Particularly, resveratrol was shown to have therapeutic properties in cancer, atherosclerosis and neurodegeneration. Resveratrol-induced benefits are modulated by multiple synergistic pathways that control oxidative stress, inflammation and cell death. Despite the lack of a definitive mechanism, both in vivo and in vitro studies suggest that resveratrol can induce a neuroprotective state when administered acutely or prior to experimental injury to the CNS. In this review, we discuss the neuroprotective potential of resveratrol in stroke, traumatic brain injury and spinal cord injury, with a focus on the molecular pathways responsible for this protection.
Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA.
Mary S
MS
Lopez
Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA.
Robert J
RJ
Dempsey
Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA. Electronic address: vemuganti@neurosurgery.wisc.edu.
Raghu
R
Vemuganti
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001930:Brain Injuries / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D000066829:Neuroprotection / Q000187:drug effects / Q000502:physiology; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*; D020521:Stroke / Q000378:metabolism / Q000517:prevention & control*
D000975:Antioxidants; D018696:Neuroprotective Agents; D013267:Stilbenes; D000077185:Resveratrol
CNS injury; Inflammation; Ischemia; Neuroprotection; Oxidative stress; Polyphenols