Reductive Cyclization of Halo-Ketones to Form 3-Hydroxy-2-OxindolesviaPalladium Catalyzed Hydrogenation: A Hydrogen-Mediated Grignard Addition.
The reductive cyclization ofN-oxoacylortho-bromoanilides to form 3-hydroxy-2-oxindoles under the conditions of palladium catalyzed hydrogenation is described. This work may be viewed as a prelude to intermolecular hydrogen-mediated Grignard-type reductive couplings of organic halides with carbonyl compounds.
Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, USA.
Inji
I
Shin
Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, USA.
Stephen D
SD
Ramgren
Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, USA.
Michael J
MJ
Krische
carbonyl addition; hydrogenation; hydroxyl oxindole; palladium; reductive coupling