Darier's Disease in Gastric Malignancy: An Unusual Paraneoplastic Phenomenon.
Darier's disease is an autosomal dominant genodermatosis resulting from ATP2A2 gene mutation. A 62-year-old male presented at our outpatient (OPD) with sudden-onset numerous dirty, warty papules over the head, neck, and back since 2 months. Histopathology of the skin lesions revealed acantholytic dyskeratosis suggestive of Darier's disease. He was referred to the gastroenterology department for some gastrointestinal (GI) symptoms where he was diagnosed with adenocarcinoma of the stomach and was subsequently operated. On his next visit to our department for follow-up, we found a marked diminution of the skin lesions in the absence of any specific treatment. In view of the above finding, we concluded that paraneoplastic dermatosis in the form of Darier's disease occurred in this patient. Paraneoplastic Darier's disease with gastric adenocarcinoma is not yet described in dermatology literature and is hence reported here.
Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Anusree
A
Gangopadhyay
Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Arghyaprasun
A
Ghosh
Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Saugato
S
Biswas
Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Joydeep
J
Singha
Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Ishad
I
Aggarwal
Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Gobinda
G
Chatterjee
Darier's disease; dyskeratosis; gastric malignancy; paraneoplastic phenomenon