Impact of acute and chronic stress hormone on male albino rat brain.
The present investigation aimed to evaluate the acute and chronic effect of stress (stress hormone) in male albino rat brain. Nor-epinephrine was used for the treatment and saline used for the control. Nor-epinephrine was dissolved in the saline and administered orally to the rats. Following nor-epinephrine administration, the brain was removed surgically at 6 h, 12 h and 45 days. Alanine tansaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) were significantly altered in the rats. Lipid peroxidation was measured as malondialdehyde (MDA), showed altered lipid peroxidation. Hematological markers such as packed cell volume (PCV), white blood cells (WBC), neutrophil, lymphocytes and hemoglobin were significantly altered compared to controls. Altered serum biochemical and hematological markers, lipid peroxidation and enzyme activities leads to adverse effect in the cellular metabolism and physiological activities of rats.
The First Department of Neurology, Cangzhou Central Hospital Cangzhou 061000, China.
Li-Li
LL
Han
Cangzhou Medical College Cangzhou 061001, China.
Ling
L
Chen
The First Department of Neurology, Cangzhou Central Hospital Cangzhou 061000, China.
Zhi-Ling
ZL
Dong
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009638:Norepinephrine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D013312:Stress, Physiological / Q000187:drug effects*; D013997:Time Factors
D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D009638:Norepinephrine
Rat; WBC; brain; enzymes; lipid peroxidation