Discovery of Some Piperine-Based Phenylsulfonylhydrazone Derivatives as Potent Botanically Narcotic Agents.
By structural modification of piperine, some piperine-based phenylsulfonylhydrazone derivatives exhibited an unprecedented and potent narcotic activity against the oriental armyworm, Mythimna separata (Walker). The ND50 values of compounds 6c and 6e against the third-instar larvae of M. separata, which were more potent than those of wilfortrine and wilforgine, were 0.0074 μmol (after 3.5 h), and 0.0075 μmol (after 7 h) per larvae, respectively. By transmission electron microscope, it demonstrated that mitochondria were vacuolated and swollen in the ganglion cell of M. separata after treatment with 6c. More importantly, 6c selectively displayed the inhibition activity on acetylcholine esterase (AchE) of M. separata. This work paved the way for further studying the insecticidal mechanism of 6c as a new and promising botanical narcotic agent.
Research Institute of Pesticidal Design &Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P. R. China.
Huan
H
Qu
1] Research Institute of Pesticidal Design &Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P. R. China [2] College of Plant Protection, Northwest A&F University, Yangling 712100, P. R. China.
Min
M
Lv
Research Institute of Pesticidal Design &Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P. R. China.
Xiang
X
Yu
College of Plant Protection, Northwest A&F University, Yangling 712100, P. R. China.
Xihong
X
Lian
1] Research Institute of Pesticidal Design &Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P. R. China [2] College of Plant Protection, Northwest A&F University, Yangling 712100, P. R. China.
Hui
H
Xu
D000470:Alkaloids / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D052117:Benzodioxoles / Q000138:chemical synthesis / Q000494:pharmacology*; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D009036:Moths / Q000187:drug effects; D009294:Narcotics / Q000138:chemical synthesis / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000138:chemical synthesis / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000494:pharmacology
D000470:Alkaloids; D052117:Benzodioxoles; D006835:Hydrazones; D007306:Insecticides; D009294:Narcotics; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D013438:Sulfhydryl Compounds; C008922:piperine