A novel nanoparticle containing neuritin peptide with grp170 induces a CTL response to inhibit tumor growth.
Malignant glioma is among the most challenging of all cancers to treat successfully. Despite recent advances in surgery, radiotherapy and chemotherapy, current treatment regimens have only a marginal impact on patient survival. In this study, we constructed a novel nanoparticle containing neuritin peptide with grp170. The nanoparticle could elicit a neuritin-specific cytotoxic T lymphocyte response to lyse glioma cells in vitro. In addition, the nanoparticle could inhibit tumor growth and improve the lifespan of tumor-bearing mice in vivo. Taken together, the results demonstrated that the nanoparticle can inhibit tumor growth and represents a promising therapy for glioma.
Department of Neurosurgery, The 476th Hospital of PLA, Fuzhou, Fujian, 350025, China.
Bangqing
B
Yuan
Department of Neurosurgery, The 476th Hospital of PLA, Fuzhou, Fujian, 350025, China.
Hanchao
H
Shen
Department of Neurosurgery, The 476th Hospital of PLA, Fuzhou, Fujian, 350025, China.
Tonggang
T
Su
Department of Neurosurgery, The 476th Hospital of PLA, Fuzhou, Fujian, 350025, China.
Li
L
Lin
Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Ting
T
Chen
Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China. yangzhao5140@sohu.com.
Zhao
Z
Yang
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000276:immunology; D045744:Cell Line, Tumor; D002857:Chromium / Q000378:metabolism; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D005910:Glioma / Q000188:drug therapy* / Q000276:immunology; D006023:Glycoproteins / Q000627:therapeutic use*; D018840:HSP70 Heat-Shock Proteins / Q000627:therapeutic use*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000008:administration & dosage / Q000648:ultrastructure; D010455:Peptides / Q000627:therapeutic use; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology* / Q000648:ultrastructure
D006023:Glycoproteins; D018840:HSP70 Heat-Shock Proteins; D010455:Peptides; C098410:glucose-regulated protein 170; D002857:Chromium
CTL; Grp170; Nanoparticle; Neuritin