Highly efficacious cognitive-coping therapy for overt or covert compulsions.
Pharmacotherapy and cognitive-behavioral therapy (CBT) present limitations when they are used to treat obsessive-compulsive disorder (OCD), a severe and debilitating psychiatric disorder. To search for more efficacious treatment, we investigated the effects of pharmacotherapy plus cognitive-coping therapy (pCCT) on adult OCD patients with overt or covert compulsions. Two hundred and fifteen OCD patients were randomized into pharmacotherapy plus psychological support (PPS, n=107) and pCCT (n=108). The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to measure severity of symptoms in the OCD patients. The Y-BOCS scores were significantly lower in pCCT than in PPS in both acute term (<3 months) and long-term follow-up. In pCCT, severity of symptoms was not different between those with covert compulsions and those with overt compulsions, but was significantly reduced at any post-treatment time-point. Y-BOCS scores in the two subtype compulsions were significantly lower in pCCT than in PPS at any post-treatpost-treatment time-point. Compared with PPS, effect size, response rate and remission rate were significantly higher in pCCT. Our findings corroborated with the hypothesis that pCCT could efficaciously treat OCD with overt compulsions or covert compulsion, suggesting that pCCT might be a potential option for adult OCD.
The Second Hospital of Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China; Workstation of Henan Province for Psychiatry experts, Kaifeng City 475003, Henan Province, PR China. Electronic address: huxianzhang@yahoo.com.
Xian-Zhang
XZ
Hu
The Second Hospital of Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
Jian-Dong
JD
Ma
The Fifth People Hospital of Kaifeng, Kaifeng City 475003, Henan Province, PR China.
Ping
P
Huang
The Second Hospital of Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
Xiao-Wen
XW
Shan
The Second Hospital of Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
Zhao-Hui
ZH
Zhang
The Second Hospital of Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
Jian-Hong
JH
Zhang
The Second Hospital of Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
Hua
H
Ouyang
Workstation of Henan Province for Psychiatry experts, Kaifeng City 475003, Henan Province, PR China; The Fifth People Hospital of Kaifeng, Kaifeng City 475003, Henan Province, PR China.
Shao-Jie
SJ
Kou
The Fifth People Hospital of Kaifeng, Kaifeng City 475003, Henan Province, PR China.
Zhi-Rong
ZR
Li
Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou City, Henan Province, PR China.
Shu-Fan
SF
Wang
The Second Hospital of Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
Hong-Zeng
HZ
Zhao
Research Center for Immunology, Xinxiang Medical University, Xinxiang 453003, Henan Province, PR China.
Hui
H
Wang
The Second Hospital of Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
Chang-Hong
CH
Wang
D000223:Adaptation, Psychological; D000328:Adult; D002997:Clomipramine / Q000627:therapeutic use; D003071:Cognition; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology / Q000534:rehabilitation*; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors; D012720:Severity of Illness Index; D016896:Treatment Outcome
D002997:Clomipramine; D017367:Selective Serotonin Reuptake Inhibitors
Cognitive-coping therapy; OCD; OCD with covert compulsions; OCD with overt compulsions; Treatment