Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans.
The pharmacological activation of stress-defense mechanisms is one of the perspective ways to increase human lifespan. The goal of the present study was to study the effects on lifespan of Drosophila melanogaster and Caenorhabditis elegans of two carotenoids: ß-carotene and fucoxanthin, which are bioactive natural substances in human diet. In addition, the effects of carotenoids on the flies survival were studied under stress conditions, including starvation, thermal stress (35°C), oxidative stress (20 mM paraquat), as well as locomotor activity, fecundity, and genes expression level. Our results demonstrated lifespan extension of flies by both carotenoids. However, the positive effects on the lifespan of C. elegans were revealed only for fucoxanthin. In presence of carotenoids decreased flies' fecundity, increased spontaneous locomotor activity and resistance to oxidative stress were detected.
Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, Dolgoprudny, 141700 Moscow Region, Russian Federation. Electronic address: ekaterinalashmanova@yandex.com.
Ekaterina
E
Lashmanova
Institute of Biology, Komi Science Center of RAS, Kommunisticheskaya St.28, 167982 Syktyvkar, Russian Federation; Syktyvkar State University, Oktyabrsky pr. 55, 167001 Syktyvkar, Russian Federation. Electronic address: kateplus@mail.ru.
Ekaterina
E
Proshkina
Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, Dolgoprudny, 141700 Moscow Region, Russian Federation; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, 119991 Moscow, Russian Federation. Electronic address: gmasyata@mail.ru.
Svetlana
S
Zhikrivetskaya
Institute of Biology, Komi Science Center of RAS, Kommunisticheskaya St.28, 167982 Syktyvkar, Russian Federation. Electronic address: microtus69@mail.ru.
Oksana
O
Shevchenko
Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, Dolgoprudny, 141700 Moscow Region, Russian Federation. Electronic address: mei@pharmcluster.ru.
Elena
E
Marusich
Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, Dolgoprudny, 141700 Moscow Region, Russian Federation. Electronic address: sl@pharmcluster.ru.
Sergey
S
Leonov
Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, Dolgoprudny, 141700 Moscow Region, Russian Federation. Electronic address: m83071@gmail.com.
Alex
A
Melerzanov
Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, Dolgoprudny, 141700 Moscow Region, Russian Federation. Electronic address: noagen@gmail.com.
Alex
A
Zhavoronkov
Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, Dolgoprudny, 141700 Moscow Region, Russian Federation; Institute of Biology, Komi Science Center of RAS, Kommunisticheskaya St.28, 167982 Syktyvkar, Russian Federation; Syktyvkar State University, Oktyabrsky pr. 55, 167001 Syktyvkar, Russian Federation; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, 119991 Moscow, Russian Federation. Electronic address: amoskalev@list.ru.
Alexey
A
Moskalev
D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D002338:Carotenoids / Q000378:metabolism; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D005260:Female; D008136:Longevity / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D024341:Xanthophylls / Q000494:pharmacology*
D024341:Xanthophylls; C025164:fucoxanthin; D002338:Carotenoids
Aging; C. elegans; D. melanogaster; Fucoxanthin; Fucoxanthin (PubChem CID: 5364094); Lifespan; Stress resistance; β-carotene; β-carotene (PubChem CID: 5280489)