HLA-B27 and psoriatic disease: a modern view of an old relationship.
Psoriasis and PsA are the main phenotypes of psoriatic disease. Both conditions are highly polygenic diseases in which stochastic and environmental factors are crucial in the pathogenic process. Although the MHC region is a highly dense genetic area, most of the genetic basis of psoriatic disease within it resides in the HLA region. For decades, HLA-C*06 has been accepted as the main descriptor of the two main phenotypes of skin psoriasis. There is now compelling evidence to suggest that HLA-C*06 is only a genetic biomarker for skin involvement and not for joint involvement in psoriatic disease. The role of HLA-B*27 in the genetic aetiology of PsA has been recognized since the 1970s. Recent population case-control studies with adequate patient groups and replication cohorts, as well as confirmation studies in family pedigrees through the use of modern molecular typing methods, have reinforced the aetiological role of this allele in PsA. These studies have offered a new vision of the role of this allele in disease expression. This review contextualizes the latest findings on the role of HLA-B27 in psoriatic disease, emphasizing those aspects of particular interest for clinical practice.
Rheumatology Division, Hospital Universitario Central de Asturias, Oviedo, Spain rubenque7@yahoo.es.
Rubén
R
Queiro
Rheumatology Division, Hospital Universitario Central de Asturias, Oviedo, Spain.
Isla
I
Morante
Rheumatology Division, Hospital Universitario Central de Asturias, Oviedo, Spain.
Iván
I
Cabezas
Rheumatology Division, Hospital Universitario Central de Asturias, Oviedo, Spain.
Belén
B
Acasuso
D020022:Genetic Predisposition to Disease; D014943:Global Health; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism
D015796:HLA-B27 Antigen
HLA-B27; HLA-Cw6; genetic epidemiology; psoriasis; psoriatic arthritis; psoriatic disease aetiology