Genetic influences on dental enamel that impact caries differ between the primary and permanent dentitions.
Clinically, primary and permanent teeth are distinct anatomically and the presentation of caries lesions differs between the two dentitions. Hence, the possibility exists that genetic contributions to tooth formation of the two dentitions are different. The purpose of this study was to test the hypothesis that genetic associations with an artificial caries model will not be the same between primary and permanent dentitions. Enamel samples from primary and permanent teeth were tested for microhardness at baseline, after carious lesion creation, and after fluoride application to verify association with genetic variants of selected genes. Associations were found between genetic variants of ameloblastin, amelogenin, enamelin, tuftelin, tuftelin interactive protein 11, and matrix metallopeptidase 20 and enamel from permanent teeth but not with enamel from primary teeth. In conclusion, our data continue to support that genetic variation may impact enamel development and consequently individual caries susceptibility. These effects may be distinct between primary and permanent dentitions.
Department of Pedodontics, School of Dentistry, Istanbul Medipol University, Istanbul, Turkey.
Merve
M
Bayram
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kathleen
K
Deeley
Clinical Research Unit, Fluminense Federal University, Niterói, RJ, Brazil.
Maria F
MF
Reis
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Vanessa M
VM
Trombetta
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Timothy D
TD
Ruff
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Regina C
RC
Sencak
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Michael
M
Hummel
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Piper M
PM
Dizak
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kelly
K
Washam
Department of Pediatric Dentistry and Orthodontics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Helena F
HF
Romanos
Clinical Research Unit, Fluminense Federal University, Niterói, RJ, Brazil.
Andrea
A
Lips
Clinical Research Unit, Fluminense Federal University, Niterói, RJ, Brazil.
Gutemberg
G
Alves
Department of Pediatric Dentistry and Orthodontics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Marcelo C
MC
Costa
Directory of Programs, National Institute of Metrology, Quality and Technology (INMETRO), Duque de Caxias, RJ, Brazil.
José M
JM
Granjeiro
Clinical Research Unit, Fluminense Federal University, Niterói, RJ, Brazil.
Leonardo S
LS
Antunes
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.|Clinical Research Unit, Fluminense Federal University, Niterói, RJ, Brazil.
Erika C
EC
Küchler
Department of Pedodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Figen
F
Seymen
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Alexandre R
AR
Vieira
dental caries; dentition; enamel microhardness; permanent; primary