Histological and Histomorphometric Human Results of HA-Beta-TCP 30/70 Compared to Three Different Biomaterials in Maxillary Sinus Augmentation at 6 Months: A Preliminary Report.
OBJECTIVE
The aim of this investigation was to examine the bone regenerative potential of newly biphasic calcium phosphate ceramics (HA-β-TCP 30/70), by assessing histological and histomorphometric results of human specimens retrieved from sinuses augmented with HA-β-TCP 30/70, and comparing them to anorganic bovine bone (ABB), mineralized solvent-dehydrated bone allograft (MSDBA), and equine bone (EB), after a healing period of 6 months.


METHODS
Four consecutive patients with edentulous atrophic posterior maxilla were included in this report. A two-stage procedure was carried out for sinus augmentation with HA-β-TCP 30/70, ABB, MSDBA, and EB. After 6 months, specimens were retrieved at the time of implant placement and processed for histological and histomorphometric analyses.


RESULTS
At histological examination, all biomaterials were in close contact with the newly formed bone and showed the same pattern of bone formation; the grafted granules were surrounded by a bridge-like network of newly formed bone. A limited number of ABB particles were partially covered by connective tissue. The histomorphometric analysis revealed 30.2% newly formed bone for Ha-β-TCP 30/70, 20.1% for ABB, 16.4% for MSDBA, and 21.9% for EB.


CONCLUSIONS
Within the limitations of the present investigation, these results support the successful use of HA-β-TCP 30/70 for sinus augmentation.
Department of Oral and Maxillofacial Sciences, Oral Surgery Unit, School of Dentistry, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Susanna
S
Annibali
Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy.
Giovanna
G
Iezzi
Department of Oral and Maxillofacial Sciences, Oral Surgery Unit, School of Dentistry, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Gian Luca
GL
Sfasciotti
Department of Biotechnologies and Medical Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Maria Paola
MP
Cristalli
Department of Oral and Maxillofacial Sciences, Oral Surgery Unit, School of Dentistry, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Iole
I
Vozza
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy.
Carlo
C
Mangano
Department of Oral and Maxillofacial Sciences, Oral Surgery Unit, School of Dentistry, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Gerardo
G
La Monaca
Department of Oral and Maxillofacial Sciences, Oral Surgery Unit, School of Dentistry, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Antonella
A
Polimeni
D000328:Adult; D000368:Aged; D018786:Bone Substitutes / Q000737:chemistry*; D016025:Bone Transplantation / Q000379:methods; D002130:Calcium Phosphates / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000166:cytology* / Q000601:surgery*; D008875:Middle Aged; D010865:Pilot Projects; D059546:Sinus Floor Augmentation / Q000379:methods*; D016896:Treatment Outcome
D018786:Bone Substitutes; D002130:Calcium Phosphates; D017886:Durapatite; C018392:tricalcium phosphate