TRPM4 in cardiac electrical activity.
TRPM4 forms a non-selective cation channel activated by internal Ca(2+). Its functional expression was demonstrated in cardiomyocytes of several mammalian species including humans, but the channel is also present in many other tissues. The recent characterization of the TRPM4 inhibitor 9-phenanthrol, and the availability of transgenic mice have helped to clarify the role of TRPM4 in cardiac electrical activity, including diastolic depolarization from the sino-atrial node cells in mouse, rat, and rabbit, as well as action potential duration in mouse cardiomyocytes. In rat and mouse, pharmacological inhibition of TRPM4 prevents cardiac ischaemia-reperfusion injuries and decreases the occurrence of arrhythmias. Several studies have identified TRPM4 mutations in patients with inherited cardiac diseases including conduction blocks and Brugada syndrome. This review identifies TRPM4 as a significant actor in cardiac electrophysiology.
Groupe Signalisation, Electrophysiologie et Imagerie des Lésions d'Ischémie-Reperfusion Myocardique, EA4650, Université de Caen Basse-Normandie, Sciences D, Esplanade de la Paix, CS 14032, 14032 Caen Cedex 5, France romain.guinamard@unicaen.fr.
Romain
R
Guinamard
EA 4173, Université Lyon 1 and Hôpital du Nord-Ouest, Lyon, France.
Patrice
P
Bouvagnet
Groupe Signalisation, Electrophysiologie et Imagerie des Lésions d'Ischémie-Reperfusion Myocardique, EA4650, Université de Caen Basse-Normandie, Sciences D, Esplanade de la Paix, CS 14032, 14032 Caen Cedex 5, France.
Thomas
T
Hof
Department of Anatomy, Hainan Medical College, Haikou, Hainan 571101, China.
Hui
H
Liu
Groupe Signalisation, Electrophysiologie et Imagerie des Lésions d'Ischémie-Reperfusion Myocardique, EA4650, Université de Caen Basse-Normandie, Sciences D, Esplanade de la Paix, CS 14032, 14032 Caen Cedex 5, France.
Christophe
C
Simard
Groupe Signalisation, Electrophysiologie et Imagerie des Lésions d'Ischémie-Reperfusion Myocardique, EA4650, Université de Caen Basse-Normandie, Sciences D, Esplanade de la Paix, CS 14032, 14032 Caen Cedex 5, France.
Laurent
L
Sallé
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003971:Diastole / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis; D050053:TRPM Cation Channels / Q000235:genetics / Q000502:physiology*
D012333:RNA, Messenger; D050053:TRPM Cation Channels; C437888:TRPM4 protein, human; D002118:Calcium
Arrhythmias; Brugada; Calcium-activated non-selective cation channel; Cardioprotection; TRPM4