A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification.
A plasmonic nanosensor (using gold nanorods) with inverse sensitivity is presented for circulating cell-free DNA quantification. The inverse sensitivity (i.e. the lower the analyte concentration, the higher the response intensity) is achieved by the unusual DNA concentration-dependent gold nanorod aggregation. This assay method can adjust the dynamic range by controlling the concentration of nanoparticles in solution.
Department of Chemistry, University College London, London, WC1H 0AJ, UK.
Roger M
RM
Pallares
Say Li
SL
Kong
Tan Hui
TH
Ru
Nguyên T K
NT
Thanh
Yi
Y
Lu
Xiaodi
X
Su
D015374:Biosensing Techniques; D002474:Cell-Free System; D004247:DNA / Q000097:blood*; D057230:Limit of Detection; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology
D004247:DNA