Antibiotic therapy in fully impacted lower third molar surgery: randomized three-arm, double-blind, controlled trial.
OBJECTIVE
The aim of this study was to evaluate the efficacy of three drug protocols in patients undergoing extraction of fully impacted lower third molars.


METHODS
Eighty surgeries were performed on healthy patients using three randomized double-blind drug protocols: group 1 (G1), amoxicillin (1 g) 1 h before surgery + 500 mg 8/8 h for 7 days; group 2 (G2), 1-g amoxicillin 1 h before surgery plus placebo, with identical appearance to G1, 8/8 h for 7 days; and group 3 (G3), placebo 1 h before surgery and 500 mg 8/8 h for 7 days. The primary outcome criterion was mouth opening, and the secondary outcome criteria were facial edema and pain. Signals as body temperature, lymphadenopathy, and dysphagia characterize the sample. Evaluation was performed at baseline and on the 4th and 7th postoperative days by the same researcher.


RESULTS
There was no difference among groups with respect to any of the parameters evaluated (p > 0.05).


CONCLUSIONS
Under these experimental conditions, there is no advantage in the administration of antibiotics in healthy patients undergoing extraction of fully impacted lower third molars with a controlled aseptic chain.
School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
Basílio Almeida
BA
Milani
School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
Henrique Camargo
HC
Bauer
Postgraduate program in Biophotonics applied to Health Sciences, Universidade Nove de Julho, Uninove, São Paulo, São Paulo, Brazil.
Hélio
H
Sampaio-Filho
Postgraduate program in Biophotonics applied to Health Sciences, Universidade Nove de Julho, Uninove, São Paulo, São Paulo, Brazil. annacrth@gmail.com.
Anna Carolina Ratto Tempestini
AC
Horliana
School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
Flávio Eduardo Guillin
FE
Perez
School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
Isabel Peixoto
IP
Tortamano
School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
Waldyr Antônio
WA
Jorge
D019072:Antibiotic Prophylaxis; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D011184:Postoperative Period; D014081:Tooth Extraction / Q000009:adverse effects / Q000379:methods*; D014095:Tooth, Impacted / Q000601:surgery*; D014313:Trismus / Q000209:etiology; D055815:Young Adult
Anti-Bacterial Agents; Infection; Oral surgical procedures; Third molar