The Mathematical Theory of Diffusion and Reaction in Enzymes Immoblized Artificial Membrane. The Theory of the Non-Steady State.
In this paper, mathematical model pertaining to the decomposition of enzyme-substrate complex in an artificial membrane is discussed. Here the transport through liquid membrane phases is considered. The model involves the system of non-linear reaction diffusion equations. The non-linear terms in this model are related to Michaelis-Menten reaction scheme. Approximate analytical expressions for the concentrations of substrate and product have been derived by solving the system of non-linear reaction diffusion equations using new approach of homotopy perturbation method for all values of Michaelis-Menten constant, diffusion coefficient, and rate constant. Approximate flux expression for substrate and product for non-steady-state conditions are also reported. A comparison of the analytical approximation and numerical simulation is also presented. The results obtained in this work are valid for the entire solution domain.
Department of Mathematics, The Standard Fireworks Rajaratnam College for Women, Sivakasi, Tamil Nadu, 626 123, India. malinidevi81@gmail.com.
Malinidevi
M
Ramanathan
Department of Mathematics, Sethu Institute of Technology, Kariapatti, Tamil Nadu, 626 115, India. rasildc@gmail.com.
Rasi
R
Muthuramalingam
Department of Mathematics, Sethu Institute of Technology, Kariapatti, Tamil Nadu, 626 115, India. raj_sms@rediffmail.com.
Rajendran
R
Lakshmanan
D000465:Algorithms; D004058:Diffusion; D004800:Enzymes, Immobilized / Q000737:chemistry*; D008567:Membranes, Artificial; D008962:Models, Theoretical
D004800:Enzymes, Immobilized; D008567:Membranes, Artificial
Homotopy perturbation method; Immobilized enzyme; Mathematical modeling; Membrane; Non-linear equations