Influence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study.
The aim of this study was to evaluate the effects of leukocyte- and platelet-rich fibrin (L-PRF) on the pain and soft tissue healing after tooth extractions. Twenty-six patients (9 males and 17 females) were treated with multiple extractions (2 to 8), with a total of 108 extractions. This was an exploratory single blinded randomized clinical trial with a split-mouth design. The pain after the surgery was assessed in each patient by the VAS scale (1 to 10) at intervals of 24-48-72-96 hours. The soft tissue healing was clinically evaluated at 3, 7, 14, and 21 days after surgery by the same examiner surgeon, using the modified Healing Index (4 to 12). The mean value of postextraction pain was 3.2 ± 0.3 in the experimental sides and 4.1 ± 0.1 in the control sides. After 7 days from the extractions, the values of modified Healing Index in the experimental and control groups were, respectively, 4.8 ± 0.6 and 5.1 ± 0.9. The use of L-PRF in postextraction sockets filling can be proposed as a useful procedure in order to manage the postoperative pain and to promote the soft tissue healing process, reducing the early adverse effects of the inflammation.
Division of Oral Surgery and Implantology, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Gaetano
G
Marenzi
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Francesco
F
Riccitiello
Private Practice, Via Austria 6, Sant'Antimo, Naples, Italy.
Mariano
M
Tia
Division of Oral Surgery and Implantology, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Alessandro
A
di Lauro
Division of Oral Surgery and Implantology, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Gilberto
G
Sammartino
D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology*; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000502:physiology; D053657:Platelet-Rich Plasma / Q000378:metabolism / Q000502:physiology*; D014081:Tooth Extraction / Q000379:methods; D014945:Wound Healing / Q000502:physiology*
D005337:Fibrin