EFFECT ON QUALITY OF LIFE AND HANDGRIP STRENGTH BY DYNAMOMETRY OF AN ENTERAL SPECIFIC SUPLEMENTS WITH BETA-HYDROXY-BETA-METHYLBUTYRATE AND VITAMIN D IN ELDERLY PATIENTS.
OBJECTIVE
the aim of our study was to investigate the effect on strenght and quality of life of an enhanced specific enteral formula with HMBD and vitamin D in elderly patients.


METHODS
we conducted an open-label study. General assessment of nutritional status included measurements of body weight, height, body mass index (kg/m2) and bioimpedance. Handgrrip strength was measured by dynamometry. QOL (quality of life) was assessed using the well validated SF 36 questonnaire. Albumin, prealbumin, transferrin and 25-OH vitamin D were measured. All these parameters were recorded at basal time and after 12 weeks of nutritional intervention.


RESULTS
patients were divided in two groups by the median percentage of weight improvement (3.4%); group 1 (percentage of weight improvement < 3.4%) and group 2 (percentage of weight improvement > 3.4%). In group 1, patients showed an improvement in prealbumin and vitamin D levels. In group 2, patients showed an improvement of BMI, weight, fat mass, fat free mass, prealbumin, vitamin D levels, role physical domain of SF 36 , general health domain of SF 36 and handgrip strength. The volumetric consumption rates of the formula were higher in group 2 than group 1 (group 1: 1.25 + 0.78 units/day [1.81 +/-0.9 g per day of HMBD) vs. group 2: 1.86 + 0.82 units/day (2.79 +/-1.1 g per day of HMBD]).


CONCLUSIONS
elderly patients with a previous weight loss and with a high consumption of a HMBD and vit D enhanced formula had a significant improvement in anthropometric, biochemical parameters, handgrip strength and quality of life.
Svo de Endocrinología y Nutrición Hospital Clínico Universitario de Valladolid, Valladolid, Spain.. redactor04@nutricionhospitalaria.com.
Daniel Antonio
DA
De Luis
Svo de Endocrinología y Nutrición Hospital Clínico Universitario de Valladolid, Valladolid, Spain.. redactor04@nutricionhospitalaria.com.
Olatz
O
Izaola
Svo de Endocrinología y Nutrición Hospital Clínico Universitario de Valladolid, Valladolid, Spain.. redactor04@nutricionhospitalaria.com.
Pablo
P
Bachiller
Svo de Endocrinología y Nutrición Hospital Clínico Universitario de Valladolid, Valladolid, Spain.. redactor04@nutricionhospitalaria.com.
Jose
J
Perez Castrillon
D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D019587:Dietary Supplements; D004750:Enteral Nutrition / Q000379:methods; D005260:Female; D015577:Geriatric Assessment; D018737:Hand Strength; D006801:Humans; D008297:Male; D053581:Muscle Strength Dynamometer; D009752:Nutritional Status; D017063:Outcome Assessment, Health Care; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014631:Valerates / Q000008:administration & dosage*; D014807:Vitamin D / Q000008:administration & dosage*
D014631:Valerates; D014807:Vitamin D; C004961:beta-hydroxyisovaleric acid