Comparative mapping of host-pathogen protein-protein interactions.
Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications. Here, we highlight the importance of harnessing genetic diversity of hosts and pathogens for uncovering the biochemical basis of pathogen restriction, virulence, fitness, and pathogenesis. We further suggest that integrating physical interaction data with orthogonal types of data will allow researchers to draw meaningful conclusions both for basic and translational science.
Department of Cellular and Molecular Pharmacology, University of California, Byers Hall, 1700 4th Street, San Francisco, CA 94158, United States; Department of Microbiology and Immunology, University of California, Genentech Hall, 600 16th Street, San Francisco, CA 94158, United States; QB3, University of California, Byers Hall, 1700 4th Street, Byers Hall, San Francisco, CA 94158, United States; J. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, United States.
Priya S
PS
Shah
Department of Cellular and Molecular Pharmacology, University of California, Byers Hall, 1700 4th Street, San Francisco, CA 94158, United States; QB3, University of California, Byers Hall, 1700 4th Street, Byers Hall, San Francisco, CA 94158, United States; J. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, United States.
Jason A
JA
Wojcechowskyj
Department of Cellular and Molecular Pharmacology, University of California, Byers Hall, 1700 4th Street, San Francisco, CA 94158, United States; QB3, University of California, Byers Hall, 1700 4th Street, Byers Hall, San Francisco, CA 94158, United States; J. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, United States.
Manon
M
Eckhardt
Department of Cellular and Molecular Pharmacology, University of California, Byers Hall, 1700 4th Street, San Francisco, CA 94158, United States; QB3, University of California, Byers Hall, 1700 4th Street, Byers Hall, San Francisco, CA 94158, United States; J. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, United States. Electronic address: nevan.krogan@ucsf.edu.
Nevan J
NJ
Krogan
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D019992:Databases as Topic; D014644:Genetic Variation; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D025941:Protein Interaction Mapping; D014764:Viral Proteins / Q000378:metabolism*; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D014764:Viral Proteins