Cobalt(III)-Catalyzed C2-Selective C-H Alkynylation of Indoles.
A cobalt(III)-catalyzed C-2 selective C-H alkynylation of indoles using hypervalent iodine-alkyne reagents is described. A broad range of synthetically useful functional groups (-F, -Cl, -Br, -CO2Me, -CN) were tolerated, providing an efficient and robust protocol for the synthesis of C-2 alkynylated indoles. The pyrimidyl and silyl protecting groups could be easily removed to give the corresponding 2-ethynyl-1H-indole.
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Zhuo-Zhuo
ZZ
Zhang
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Bin
B
Liu
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Cai-Yun
CY
Wang
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Bing-Feng
BF
Shi
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry; D015394:Molecular Structure
D000480:Alkynes; D007211:Indoles; D003035:Cobalt; D007455:Iodine