Probabilistic cardiac and respiratory based classification of sleep and apneic events in subjects with sleep apnea.
Current clinical standards to assess sleep and its disorders lack either accuracy or user-friendliness. They are therefore difficult to use in cost-effective population-wide screening or long-term objective follow-up after diagnosis. In order to fill this gap, the use of cardiac and respiratory information was evaluated for discrimination between different sleep stages, and for detection of apneic breathing. Alternative probabilistic visual representations were also presented, referred to as the hypnocorrogram and apneacorrogram. Analysis was performed on the UCD sleep apnea database, available on Physionet. The presence of apneic events proved to have a significant impact on the performance of a cardiac and respiratory based algorithm for sleep stage classification. WAKE versus SLEEP discrimination resulted in a kappa value of κ = 0.0439, while REM versus NREM resulted in κ = 0.298 and light sleep (N1N2) versus deep sleep (N3) in κ = 0.339. The high proportion of hypopneic events led to poor detection of apneic breathing, resulting in a kappa value of κ = 0.272. While the probabilistic representations allow to put classifier output in perspective, further improvements would be necessary to make the classifier reliable for use on patients with sleep apnea.
Department of Mechanical Engineering, Biomechanics section, KU Leuven, Celestijnenlaan, Leuven, Belgium. Department of Electrical Engineering (ESAT), STADIUS, KU Leuven, Kasteelpark Arenberg, Leuven, Belgium. Medical Information Technologies, iMinds, Leuven, Belgium.
T
T
Willemen
C
C
Varon
A Caicedo
AC
Dorado
B
B
Haex
J
J
Vander Sloten
S
S
Van Huffel
D000328:Adult; D000368:Aged; D005260:Female; D006321:Heart / Q000502:physiology* / Q000503:physiopathology*; D006801:Humans; D000069550:Machine Learning; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011336:Probability; D012119:Respiration; D012815:Signal Processing, Computer-Assisted; D012890:Sleep; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000503:physiopathology*; D012894:Sleep Stages