Ibrutinib and rituximab induced rapid response in refractory Richter syndrome.
We report a 53-year-old man diagnosed with Richter syndrome. He was heavily pretreated and was refractory to prior therapy. He received rituximab and ibrutinib, and achieved a significant response after 1 month of therapy. Our case illustrates the importance of investigation of rituximab and ibrutinib in Richter's syndrome.
Comprehensive Cancer Center, Wake Forest University Medical Center Boulevard, Winston-Salem, North Carolina, 27157.
Zanetta
Z
Lamar
Department of Pharmacy, Wake Forest Baptist Health Medical Center Boulevard, Winston-Salem, North Carolina, 27157.
LeAnne
L
Kennedy
Comprehensive Cancer Center, Wake Forest University Medical Center Boulevard, Winston-Salem, North Carolina, 27157.
Brooke
B
Kennedy
Comprehensive Cancer Center, Wake Forest University Medical Center Boulevard, Winston-Salem, North Carolina, 27157.
Mary
M
Lynch
Comprehensive Cancer Center, Wake Forest University Medical Center Boulevard, Winston-Salem, North Carolina, 27157.
Amanda
A
Goad
Comprehensive Cancer Center, Wake Forest University Medical Center Boulevard, Winston-Salem, North Carolina, 27157.
David
D
Hurd
Comprehensive Cancer Center, Wake Forest University Medical Center Boulevard, Winston-Salem, North Carolina, 27157.
Zachariah
Z
McIver
Ibrutinib; Richter; Richter syndrome; Richter’s transformation; rituximab