Knowledge-based immunosuppressive therapy for kidney transplant patients--from theoretical model to clinical integration.
Immunosuppressive therapy is a risky necessity after a patient received a kidney transplant. To reduce risks, a knowledge-based system was developed that determines the right dosage of the immunosuppresive agent Tacrolimus. A theoretical model, to classify medication blood levels as well as medication adaptions, was created using data from almost 500 patients, and over 13.000 examinations. This model was then translated into an Arden Syntax knowledge base, and integrated directly into the hospital information system of the Vienna General Hospital. In this paper we give an overview of the construction and integration of such a system.
Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Austria.
Walter
W
Seeling
Department of Internal Medicine III, Vienna General Hospital and Medical University of Vienna, Austria.
Max
M
Plischke
Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Austria.
Jeroen S
JS
de Bruin
Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Austria.
Christian
C
Schuh
D001317:Austria; D020000:Decision Support Systems, Clinical / Q000458:organization & administration*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006084:Graft Rejection / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D051188:Knowledge Bases; D008509:Medication Systems / Q000458:organization & administration*; D017146:Models, Organizational; D018511:Systems Integration; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects; D018875:Vocabulary, Controlled
D007166:Immunosuppressive Agents; D016559:Tacrolimus