[Clinical predictors of cytomegalovirus infection after liver transplantation].
OBJECTIVE
To investigate the clinical predictors of cytomegalovirus (CMV) infection after liver transplantation.


METHODS
The clinical data of 182 patients (146 male and 36 female with a mean age of (50 ± 7) years) receiving liver transplantation in Beijing Chaoyang Hospital between January 2004 and December 2008 were retrospectively analyzed.All patients were divided into two groups, namely the CMV infection group (n=24) and the control group (n=158). Logistic regression was used to identify the predictive factors of postoperative CMV infection.


RESULTS
According to univariate analysis results, the factors for CMV infection were acute liver failure (P=0.032), MELD score ≥ 30 (P=0.001), liver retransplantation (P=0.002), acute rejection (P=0.000) and delayed graft function (P=0.022). According to multi-analysis results, MELD score ≥ 30 (P=0.037, 95%CI:1.194-271.461) and acute rejection (P=0.033, 95%CI:1.179-51.863) were proved to be independent predictors by multivariate analysis.


CONCLUSIONS
The study indicates that MELD score ≥ 30 and acute rejection are the independent predictors of CMV infection.
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Beijing Organ Transplant Center, Capital Medical University, Beijing 100020, China.
Jiantao
J
Kou
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Beijing Organ Transplant Center, Capital Medical University, Beijing 100020, China.
Jiqiao
J
Zhu
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Beijing Organ Transplant Center, Capital Medical University, Beijing 100020, China.
Hua
H
Fan
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Beijing Organ Transplant Center, Capital Medical University, Beijing 100020, China.
Jun
J
Ma
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Beijing Organ Transplant Center, Capital Medical University, Beijing 100020, China.
Ping
P
Li
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Beijing Organ Transplant Center, Capital Medical University, Beijing 100020, China.
Dongdong
D
Han
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Beijing Organ Transplant Center, Capital Medical University, Beijing 100020, China; Email: heqiang349@sina.com.
Qiang
Q
He
D000328:Adult; D000068476:Beijing; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D058625:End Stage Liver Disease / Q000175:diagnosis; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000821:virology*; D012086:Reoperation; D012189:Retrospective Studies; D012720:Severity of Illness Index