Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators.
High stability of the complexes formed at physiological pH is one of the basic requisites that a good iron chelator must possess. At the same time the chelating agent must be selective toward iron, i.e., the stability of iron complexes must be significantly higher than that of the complexes formed with essential metal ions, in order that these last ones do not perturb iron chelation. In the frame of our research on iron chelators we have designed and synthesized a series of tetradentate derivatives of kojic acid, and examined their binding properties toward Fe(3+) and Al(3+). In this paper, for a characterization of the behavior of the proposed iron chelating agents in biological fluids, their complex formation equilibria with copper(II) and zinc(II) ions have been fully characterized together with a speciation study, showing the degree at which the iron chelators interfere with the homeostatic equilibria of these two essential metal ions.
Department of Chemistry and Geology, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy. Electronic address: lachowicz@unica.it.
Joanna Izabela
JI
Lachowicz
Department of Chemistry and Geology, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy.
Valeria Marina
VM
Nurchi
Department of Chemistry and Geology, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy.
Guido
G
Crisponi
Department of Chemistry and Geology, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy.
Maria de Guadalupe
Mde G
Jaraquemada-Pelaez
Faculty of Chemistry, University of Wrocław, Joliot-Curie Street 14, 50-383 Wrocław, Poland.
Małgorzata
M
Ostrowska
Faculty of Chemistry, University of Wrocław, Joliot-Curie Street 14, 50-383 Wrocław, Poland.
Julia
J
Jezierska
Faculty of Chemistry, University of Wrocław, Joliot-Curie Street 14, 50-383 Wrocław, Poland.
Elżbieta
E
Gumienna-Kontecka
Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Massimiliano
M
Peana
Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Maria Antonietta
MA
Zoroddu
Laboratorio de Estudios Cristalográficos, IACT, CSIC-Universidad de Granada, Av. de las Palmeras 4, E-18100 Armilla, Granada, Spain.
Duane
D
Choquesillo-Lazarte
Department of Inorganic Chemistry, Faculty of Pharmacy, Campus Cartuja, University of Granada, E-18071 Granada, Spain.
Juan
J
Niclós-Gutiérrez
Department of Inorganic Chemistry, Faculty of Pharmacy, Campus Cartuja, University of Granada, E-18071 Granada, Spain.
Josefa Maria
JM
González-Pérez
D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007502:Iron Chelating Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry*
C550810:4-hydroxypyrone; D007502:Iron Chelating Agents; D011753:Pyrones; D003300:Copper; D015032:Zinc
EPR; NMR; Potentiometry; Zinc(II) copper(II) complexes