Severity of polymicrobial sepsis modulates mitochondrial function in rat liver.
Mitochondrial dysfunction is assumed to be an important contributor to multi organ dysfunction syndrome. Here, the effects of varying degrees of sepsis on hepatic mitochondrial function were investigated. Moderate or more severe sepsis was induced in rats using a colon ascendens stent peritonitis (CASP)-model (16 G and 14 G stent respectively). Respiratory control ratio (RCR) was significantly higher in the 16 G-group and unchanged in the 14 G-group compared with healthy controls. The ADP/O ratio was similar in all groups. Our results indicate that different severities of sepsis differently influence the mitochondrial function, which could be a sign of adaptive reaction.
Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany. Electronic address: anna.herminghaus@med.uni-duesseldorf.de.
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Herminghaus
Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.
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Barthel
Institute of Cardiovascular Physiology, Heinrich-Heine University Duesseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany.
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Heinen
Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.
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Beck
Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.
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Vollmer
Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.
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Bauer
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, 1200 Vienna, Austria.
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Weidinger
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, 1200 Vienna, Austria.
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Kozlov
Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.
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Picker
D000818:Animals; D019069:Cell Respiration; D060085:Coinfection / Q000150:complications* / Q000473:pathology*; D004195:Disease Models, Animal; D008099:Liver / Q000473:pathology*; D008297:Male; D008928:Mitochondria / Q000473:pathology*; D010538:Peritonitis / Q000150:complications / Q000473:pathology; D017208:Rats, Wistar; D018805:Sepsis / Q000150:complications* / Q000473:pathology*
Colon ascendens stent peritonitis; Mitochondrial function; Respirometry; Sepsis