18F-Florbetapir and 18F-FDG PET/CT in Systemic Immunoglobulin Light Chain Amyloidosis Involving the Peripheral Nerves.
We present a case of both F-FDG and F-florbetapir uptake in a biopsy-confirmed immunoglobulin light chain (AL) amyloidosis involving the peripheral nerves. AL amyloidosis is the most common cause of acquired amyloid polyneuropathy, manifesting with both sensorimotor and autonomic neuronal dysfunction. Given the overlapping MRI and FDG PET/CT appearances of several different causes of peripheral neuropathy, F-florbetapir PET/CT provides another potential tool in the imaging algorithm of these patients and may guide targeted fascicular biopsy for pathologic confirmation.
From the Departments of *Radiology, †Neurosurgery, and ‡Orthopedics, §Division of Hematology, and ∥Department of Immunology, Mayo Clinic, Rochester, MN.
Stephen M
SM
Broski
Robert J
RJ
Spinner
Benjamin M
BM
Howe
Angela
A
Dispenzieri
Geoffrey B
GB
Johnson
D017772:Amyloid Neuropathies / Q000000981:diagnostic imaging*; D000686:Amyloidosis / Q000000981:diagnostic imaging*; D000814:Aniline Compounds; D005026:Ethylene Glycols; D019788:Fluorodeoxyglucose F18; D006801:Humans; D000075363:Immunoglobulin Light-chain Amyloidosis; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
D000814:Aniline Compounds; D005026:Ethylene Glycols; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C545186:florbetapir