Discordant Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome in identical twins - a case report and implications for reproduction in MRKH women.
Infertility has previously been considered as an inevitable consequence of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. With modern assisted reproductive technology (ART) techniques becoming increasingly accessible, MRKH women have the opportunity for their own genetic offspring. The availability of such technology, however, increases the importance of understanding the aetiology of this complex condition. The literature debating the relevance of genetic versus post-zygotic events in the aetiology of MRKH syndrome is reviewed in the context of this report of monozygotic twins discordant for MRKH syndrome.
a Department of Reproductive Endocrinology, Womens' Health Division , Auckland District Health Board , Auckland , New Zealand .|b Department of Endocrinology , Fertility Associates Auckland , Auckland , New Zealand .|c Department of Obstetrics and Gynaecology , University of Auckland University , Auckland , New Zealand , and.
Stella Ruth
SR
Milsom
a Department of Reproductive Endocrinology, Womens' Health Division , Auckland District Health Board , Auckland , New Zealand .|b Department of Endocrinology , Fertility Associates Auckland , Auckland , New Zealand .
Cara Megan
CM
Ogilvie
d Department of Paediatric Endocrinology , Auckland District Health Board , Auckland , New Zealand.
Craig
C
Jefferies
b Department of Endocrinology , Fertility Associates Auckland , Auckland , New Zealand .|c Department of Obstetrics and Gynaecology , University of Auckland University , Auckland , New Zealand , and.
Lynsey
L
Cree
D058489:46, XX Disorders of Sex Development / Q000235:genetics*; D000293:Adolescent; D000013:Congenital Abnormalities / Q000235:genetics*; D004200:Diseases in Twins; D006801:Humans; D009095:Mullerian Ducts / Q000002:abnormalities*; D009139:Musculoskeletal Abnormalities / Q000000981:diagnostic imaging / Q000235:genetics*; D011859:Radiography; D013933:Thumb / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014430:Twins, Monozygotic
Discordance; Mayer-Rokitansky-Kuster-Hauser syndrome; monozygotic twins