ILC Lineage Specification: To Be or Not 11b, That Is the Question.
The transcription factor Bcl11b is important for T cell development and maintaining their phenotype. In this issue of Immunity, Califano et al. (2015) show that Bcl11b has a role in specifying type II innate lymphoid cell (ILC2) identity and blocks their conversion to ILC3s.
Department of Life Sciences, Imperial College, London SW7 2AZ, UK.
Tomasz
T
Kostrzewski
Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Electronic address: h.brady@imperial.ac.uk.
Hugh J M
HJ
Brady
D000818:Animals; D044082:Citrobacter rodentium / Q000276:immunology*; D004756:Enterobacteriaceae Infections / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D012097:Repressor Proteins / Q000378:metabolism*; D018418:Th2 Cells / Q000276:immunology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins