New trimethyl chitosan-based composite nanoparticles as promising antibacterial agents.
In the present study, densely dispersed silver nanoparticles (Ag NPs) were rapidly green synthesized in the presence of Rumex dentatus aqueous extract, followed by UV-irradiation reduction. The Ag NPs were characterized using UV-vis spectroscopy, FTIR, XRD, and TEM. Then, the Ag NPs were incorporated into interpenetrating polymeric networks based on cationic trimethyl chitosan (TMCS) and anionic poly(acrylamide-co-sodium acrylate) copolymer to develop a new series of composite nanoparticles as potential antibacterial agents. Both TMCS and poly(acrylamide-co-sodium acrylate) were prepared in the study, and characterized using FTIR, DSC, and SEM. The synthesized Ag NPs showed high purity and uniform particle size distribution with particle size ranged between 5 and 30 nm. The composite nanoparticles demonstrated homogeneous spherical shape with size in the range of 378-402 nm. Both Ag NPs and the composite nanoparticles showed promising bactericidal activity as compared with the control. Moreover, the antibacterial activity of the composite nanoparticles increased along with increasing the concentrations of Ag NPs and the TMCS.
a Zewail City of Science and Technology, Center for Materials Science, Universityof Science and Technology , Giza , Egypt.|b Faculty of Science , Mansoura University , Mansoura , Egypt , and.
Ibrahim
I
El-Sherbiny
a Zewail City of Science and Technology, Center for Materials Science, Universityof Science and Technology , Giza , Egypt.|c Biological Advanced Materials, Department of Physics, Faculty of Science, Mansoura University , Mansoura , Egypt.
Ehab
E
Salih
c Biological Advanced Materials, Department of Physics, Faculty of Science, Mansoura University , Mansoura , Egypt.
Fikry
F
Reicha
D000178:Acrylamides / Q000138:chemical synthesis / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001413:Bacillus thuringiensis / Q000187:drug effects; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004534:Egypt; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D031804:Rumex / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
D000178:Acrylamides; D000900:Anti-Bacterial Agents; C118071:N-trimethyl chitosan chloride; D010936:Plant Extracts; C431184:poly(acrylamide-co-acrylic acid); D014867:Water; D012834:Silver; D048271:Chitosan
Antibacterial; Rumex dentatus; green synthesis; nanocomposites; silver nanoparticles; trimethyl chitosan