Marine Indole Alkaloids.
Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed.
Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. netz@uni-mainz.de.
Natalie
N
Netz
Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. netz@uni-mainz.de.
Till
T
Opatz
D000890:Anti-Infective Agents / Q000378:metabolism / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D059001:Aquatic Organisms / Q000378:metabolism; D001685:Biological Factors / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D026121:Indole Alkaloids / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001685:Biological Factors; D026121:Indole Alkaloids
alkaloids; bisindoles; carbolines; diketopiperazines; indoles; marine natural products; nitrogen heterocycles; prenylated indoles