Characteristics of subthalamic oscillatory activity in parkinsonian akinetic-rigid type and mixed type.
OBJECTIVE
To explore neurons with β oscillatory activity in the subthalamic nucleus (STN) in relation to parkinsonian motor signs.


METHODS
We studied 27 patients with Parkinson's disease (PD) who underwent electrode implantation for STN deep brain stimulation. Thirteen patients were classified as akinetic-rigid (AR) type and 14 patients were classified as mixed type. Microelectrode recording was performed in the STN and the electromyogram (EMG) was simultaneously recorded. Single-unit and spectral analyses were performed. Coherence analysis was used to explore the relationship between β oscillatory activity and EMG activity. Unpaired t-test and chi-square were used to compare the differences between the two PD types.


RESULTS
Of 130 neurons identified in the AR type, 43.8% were β oscillatory neurons (mean: 21.3 ± 6.87 Hz, βFB) and 0.8% were tremor frequency oscillatory neurons (4-6 Hz, TFB). Of 102 neurons identified in the mixed type, 19.6% were β oscillatory neurons and 26.5% were TFB oscillatory neurons. There was a significant difference in proportion of neurons with βFB and TFB oscillations between the two PD groups. Additionally, 12% of the βFB oscillatory neurons were coherent with limb EMG of the AR type, but there was no coherence in the mixed type. Most oscillatory neurons were localized in the dorsal portion of the STN.


CONCLUSIONS
The STN βFB oscillatory neurons correlate with parkinsonian rigidity-bradykinesia. The high proportion of βFB oscillatory neurons found in the AR type of PD is indirect evidence for their importance in generating motor impairment.
a 1 Beijing Institute of Functional Neurosurgery, Xuanwu Hospital , Capital Medical University , Beijing , China.|b 2 Center of Parkinson's Disease , Beijing Institute for Brain Disorders , Beijing , China.|c 3 Key Laboratory of Neurodegenerative Diseases (Capital Medical University) , Ministry of Education , Beijing , China.
Huanhuan
H
Feng
a 1 Beijing Institute of Functional Neurosurgery, Xuanwu Hospital , Capital Medical University , Beijing , China.|b 2 Center of Parkinson's Disease , Beijing Institute for Brain Disorders , Beijing , China.|c 3 Key Laboratory of Neurodegenerative Diseases (Capital Medical University) , Ministry of Education , Beijing , China.
Ping
P
Zhuang
d 4 Human Motor Control Section, Medical Neurology Branch , National Institute of Neurological Disorders and Stroke, NIH , Bethesda , MD , USA.
Mark
M
Hallett
a 1 Beijing Institute of Functional Neurosurgery, Xuanwu Hospital , Capital Medical University , Beijing , China.|b 2 Center of Parkinson's Disease , Beijing Institute for Brain Disorders , Beijing , China.|c 3 Key Laboratory of Neurodegenerative Diseases (Capital Medical University) , Ministry of Education , Beijing , China.
Yuqing
Y
Zhang
a 1 Beijing Institute of Functional Neurosurgery, Xuanwu Hospital , Capital Medical University , Beijing , China.|b 2 Center of Parkinson's Disease , Beijing Institute for Brain Disorders , Beijing , China.|c 3 Key Laboratory of Neurodegenerative Diseases (Capital Medical University) , Ministry of Education , Beijing , China.
Jianyu
J
Li
a 1 Beijing Institute of Functional Neurosurgery, Xuanwu Hospital , Capital Medical University , Beijing , China.|b 2 Center of Parkinson's Disease , Beijing Institute for Brain Disorders , Beijing , China.|c 3 Key Laboratory of Neurodegenerative Diseases (Capital Medical University) , Ministry of Education , Beijing , China.
Yongjie
Y
Li
D000328:Adult; D000368:Aged; D001611:Beta Rhythm / Q000502:physiology*; D004567:Electrodes, Implanted; D004576:Electromyography; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000503:physiopathology; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000145:classification / Q000503:physiopathology*; D020531:Subthalamic Nucleus / Q000503:physiopathology*
Parkinson's disease; akinetic-rigid type; microelectrode recordings; oscillatory activity; subthalamic nucleus