MicroRNAs and Noncoding RNAs in Hepatic Lipid and Lipoprotein Metabolism: Potential Therapeutic Targets of Metabolic Disorders.
Noncoding RNAs and microRNAs (miRNAs) represent an important class of regulatory molecules that modulate gene expression. The role of miRNAs in diverse cellular processes such as cancer, apoptosis, cell differentiation, cardiac remodeling, and inflammation has been intensively explored. Recent studies further demonstrated the important roles of miRNAs and noncoding RNAs in modulating a broad spectrum of genes involved in lipid synthesis and metabolic pathways. This overview focuses on the role of miRNAs in hepatic lipid and lipoprotein metabolism and their potential as therapeutic targets for metabolic syndrome. This includes recent advances made in the understanding of their target pathways and the clinical development of miRNAs in lipid metabolic disorders.
Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Neetu
N
Sud
Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.|Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Jennifer
J
Taher
Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Qiaozhu
Q
Su
D000818:Animals; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*
D008074:Lipoproteins; D035683:MicroRNAs; D022661:RNA, Untranslated
drug-development; dyslipidemia; metabolic syndrome; microRNAs; noncoding RNAs