Primary Pleural Synovial Sarcoma Treated with Pazopanib.
A 42-year-old woman presented with chest pain and breathlessness with a nodule measuring 2×2 cm in size at the base of the right lung. A bronchoscopic examination did not reveal any malignancy. However, the patient developed difficulty in breathing, enlargement of the nodule, and right pleural effusion 14 days later. A video-assisted thoracic surgical biopsy specimen revealed the presence of pleural synovial sarcoma. The patient was treated with doxorubicin-ifosfamide combination chemotherapy because of metastasis to the pelvis. However, after a transient partial clinical response, there was a relapse of refractory disease. Although treated with pazopanib as second-line chemotherapy, the patient died eight months after the initial presentation.
Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan.
Arata
A
Sugitani
Kazuhisa
K
Asai
Kazuya
K
Kojima
Yosuke
Y
Eguchi
Tomoya
T
Kawaguchi
Masahiko
M
Ohsawa
Kazuto
K
Hirata
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002637:Chest Pain / Q000209:etiology; D004317:Doxorubicin / Q000008:administration & dosage; D004417:Dyspnea / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007191:Indazoles; D009364:Neoplasm Recurrence, Local / Q000150:complications; D016066:Pleural Effusion, Malignant / Q000209:etiology*; D010997:Pleural Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D011743:Pyrimidines / Q000008:administration & dosage*; D013584:Sarcoma, Synovial / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D013449:Sulfonamides / Q000008:administration & dosage*
D007191:Indazoles; D011743:Pyrimidines; D013449:Sulfonamides; C516667:pazopanib; D004317:Doxorubicin; D007069:Ifosfamide