Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease.
Evidence from human histopathology and experimental studies with rodents and zebrafish has shown that hepatocytes and cholangiocytes may function as facultative stem cells for each other in conditions of impaired regeneration. The interpretation of the findings derived from these studies has generated considerable discussion and some controversies. This review examines the evidence obtained from the different experimental models and considers implications that these studies may have for human liver disease.
Department of Pathology University of Pittsburgh School of Medicine.
George K
GK
Michalopoulos
Department of Pediatric Gastroenterology University of Pittsburgh School of Medicine.
Zahida
Z
Khan
D000818:Animals; D001653:Bile Ducts, Intrahepatic / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008107:Liver Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008115:Liver Regeneration; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology*
Cholangiocytes; Hepatocytes; Liver Progenitor Cell; Liver-Specific Tissue Stem Cells; Transdifferentiation