A Kinase Divided.
In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug resistance.
Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Aroon S
AS
Karra
Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Clinton A
CA
Taylor
Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Curtis A
CA
Thorne
Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: melanie.cobb@utsouthwestern.edu.
Melanie H
MH
Cobb
D000818:Animals; D063646:Carcinogenesis / Q000187:drug effects*; D005260:Female; D006801:Humans; D019950:Mitogen-Activated Protein Kinase 1 / Q000037:antagonists & inhibitors*; D055503:Protein Multimerization / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000494:pharmacology*; D018631:ras Proteins / Q000378:metabolism*
D054852:Small Molecule Libraries; D019950:Mitogen-Activated Protein Kinase 1; D018631:ras Proteins