[An analysis for the clinical difference between post infectious irritable bowel syndrome and non post infectious irritable bowel syndrome].
OBJECTIVE
To study the clinical discrepancy between patients with post infectious irritable bowel syndrome (PI-IBS) and non post infectious irritable bowel syndrome (NPI-IBS) , and assess the value of serum intestinal fatty acid binding protein (I-FABP) for differential diagnosis.


METHODS
A total of 117 patients with PI-IBS, 201 patients with NPI-IBS and 31 healthy controls were prospectively recruited in General Liberation Army Hospital from 2010 to 2013. Plasma samples and clinical data were collected. Serum I-FABP level was measured by an enzyme-linked immunosorbent assay.


RESULTS
The median age of patients with PI-IBS was 36 years. The median time to diagnosis in PI-IBS group was significantly longer than that in NPI-IBS group [(19.7 ± 10.3)months vs (11.4 ± 5.3) months, P < 0.05]. Similarly, the proportion of anxiety [58.1%(68/117) vs 28.9%(58/201), P < 0.05] and the value of I-FABP [(42.6 ± 14.8) µg/L vs (17.3 ± 11.5) µg/L, P < 0.05] in PI-IBS group were significant higher than NPI-IBS patients. The level of I-FABP of healthy controls [(10.6 ± 8.2) µg/L] was also significantly lower than that of PI-IBS patients (P < 0.05), yet no difference from that of NPI-IBS group. The I-FABP value of subgroup PI-IBS patients with diarrhoea (IBS-D) was significant higher than that of NPI-IBS group [(54.8 ± 9.3)µg/L vs (12.3 ± 6.2) µg/L, P < 0.05]. However, other parameters including gender, age, GSRS score, and I-FABP value of subgroup constipation (IBS-C) and mix (IBS-M), were not different between PI-IBS group and NPI-IBS group (all P > 0.05).


CONCLUSIONS
PI-IBS is an occult intestinal inflammation disease with mucosa injury. I-FABP might be a potential testing marker for the diagnosis of PI-IBS.
Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing 100853, China.
Hui
H
Shi
Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing 100853, China; Email: wanjun@163.com.
Jun
J
Wan
Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing 100853, China.
Wenhui
W
Liu
Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing 100853, China.
Binbin
B
Su
D001007:Anxiety / Q000097:blood / Q000209:etiology; D016022:Case-Control Studies; D003141:Communicable Diseases; D003248:Constipation / Q000097:blood / Q000209:etiology; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000097:blood / Q000209:etiology; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D043183:Irritable Bowel Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology*; D008297:Male; D011446:Prospective Studies
D050556:Fatty Acid-Binding Proteins