Gut-Pancreatic Axis AMPlified in Islets of Langerhans.
Microbially derived metabolites in the intestine regulate host immunity and impact disease pathophysiology in various organs. Sun et al. (2015) suggest a direct effect of microbial metabolites on pancreatic endocrine cells in regulating type 1 diabetes pathophysiology.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Stacy H
SH
Ryu
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: stappenb@pathology.wustl.edu.
Thaddeus S
TS
Stappenbeck
D000818:Animals; D054804:Cathelicidins / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D050417:Insulin-Secreting Cells / Q000276:immunology*; D007422:Intestines / Q000276:immunology*; D008297:Male; D064307:Microbiota / Q000502:physiology*; D010179:Pancreas / Q000276:immunology*
D054804:Cathelicidins