Beneficial effects of hyperbaric oxygen on edema in rat hippocampus following traumatic brain injury.
Hyperbaric oxygen (HBO) therapy helps alleviate secondary injury following brain trauma [traumatic brain injury (TBI)], although the mechanisms remain unclear. In this study, we assessed recovery of post-TBI spatial learning and memory in rats using the Morris water maze (MWM) and measured changes in apparent diffusion coefficient in the hippocampus by diffusion-weighted imaging (DWI) to evaluate possible therapeutic effects of HBO on TBI-associated brain edema. DWIs were obtained 8, 24, 48 h, 7 days, and 14 days post-TBI. Daily HBO therapy significantly improved post-TBI MWM performance and reduced edema in the ipsilateral hippocampus, suggesting that the therapeutic efficacy of HBO is mediated, at least in part, by a reduction in brain edema.
Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China.
Su
S
Liu
Department of Pathology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China.
Ying
Y
Liu
Department of Rehabilitation Medicine, Wuxi People's Hospital, 299 Qingyang Road, Wuxi, 214023, China.
Shukun
S
Deng
Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China.
Aisong
A
Guo
Department of Imaging, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China.
Xiubing
X
Wang
Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China. sgyrm@163.com.
Guangyu
G
Shen
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001929:Brain Edema / Q000209:etiology / Q000628:therapy*; D001930:Brain Injuries / Q000150:complications / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging; D004195:Disease Models, Animal; D006624:Hippocampus / Q000473:pathology*; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology
Diffusion-weighted imaging; Hyperbaric oxygen; Traumatic brain injury