Anemia and Outcome in Outpatients With Peripheral Artery Disease.
The influence of anemia on outcome in stable outpatients with peripheral artery disease (PAD) has not been consistently investigated. We used data from the Factores de Riesgo y ENfermedad Arterial (FRENA) Registry to compare ischemic events and mortality rates in stable outpatients with symptomatic PAD and anemia. Of 1663 patients with PAD, 208 (12.5%) had anemia. Over 18 months, patients with anemia had a higher rate of myocardial infarction (MI; rate ratio [RR]: 2.10; 95% confidence interval [CI]: 1.04-3.99), limb amputation (RR: 2.98; 95%CI: 1.70-5.05), and higher mortality (RR: 3.58; 95%CI: 2.39-5.28) than those without anemia. The rates of ischemic stroke (RR: 0.75; 95%CI: 0.23-1.93) and major bleeding (RR: 0.93; 95%CI: 0.15-3.51) were similar. On multivariable analysis, anemia was associated with an increased risk to die (hazard ratio [HR]: 2.32; 95%CI: 1.53-3.50) but not to develop MI (HR: 1.49; 95%CI: 0.73-3.05) or to have limb amputation (HR: 1.49; 95%CI: 0.86-2.59). In stable outpatients with PAD, anemia was associated with increased mortality but not with an increased rate of subsequent ischemic events or major bleeding.
Department of Vascular Surgery, Hospital Universitari Germans Trias i Pujol, Badalona, Spain Facultad de Medicina, Universitat Autónoma de Barcelona, Barcelona, Spain paulinaperezramirez@gmail.com.
Paulina
P
Perez
Department of Vascular Surgery, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Carlos
C
Esteban
Department of Neurology, Hospital San Pedro de Alcántara, Cáceres, Spain.
Pedro Enrique Jiménez
PE
Caballero
Department of Internal Medicine, Hospital San Pedro de Alcántara, Cáceres, Spain.
Juan Francisco Sánchez
JF
Muñoz-Torrero
Department of Rehabilitation, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
María Teresa Pascual
MT
Soria
Department of Internal Medicine, Hospital de Alcañiz, Alcañiz, Teruel, Spain.
Eduardo
E
Aguilar
Department of Vascular Surgery, CST-Hospital de Terrassa, Terrassa, Barcelona, Spain.
Lorenzo Ramón Álvarez
LR
Rodríguez
Department of Internal Medicine, Hospital Municipal de Badalona, Badalona, Spain.
Joan Carles
JC
Sahuquillo
Primary Healthcare, ABS Gaudi, Barcelona, Spain.
Ana María García
AM
Díaz
Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
Manuel
M
Monreal
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000379:methods; D000740:Anemia / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D003324:Coronary Artery Disease / Q000150:complications* / Q000628:therapy; D005260:Female; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000628:therapy; D010045:Outpatients; D058729:Peripheral Arterial Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000628:therapy
anemia; mortality; myocardial infarction; outcome; peripheral artery disease