Factors associated with low femoral neck bone mineral density in very elderly Chinese males.
OBJECTIVE
This study was designed to identify factors associated with the femoral neck bone mineral density (FNBMD) of the very elderly (aged 80 or more) Chinese males.


METHODS
A total of 1177 very elderly Chinese males were recruited into the study, and subjected to FNBMD, biochemical parameters, bone turnover markers, and serum sex steroids assays. Univariate and multivariate regression analyses were performed to identify factors independently related to FNBMD.


RESULTS
It was demonstrated that age (β=-0.003, P=0.035), concomitant chronic obstructive pulmonary disease (COPD, β=-0.027, P=0.009), serum β-C-telopeptide of type 1 collagen (β-CTX, β=-0.097, P<0.001), and parathyroid hormone (PTH, β=-0.001, P=0.004) were negatively correlated with the FNBMD, while body mass index (BMI, β=0.009, P<0.001), and serum estradiol (β=0.001, P=0.038) were positively related to FNBMD in very elderly Chinese males.


CONCLUSIONS
An integrated intervention should be implemented to increase the BMD of the very elderly males, with special attention to preventing and curing COPD, reducing serum β-CTX and PTH levels, as well as keeping a proper BMI and serum estradiol level.
Center for Diagnosis and Treatment of Osteoporosis, Zhejiang Provincial People's Hospital, Hangzhou, China. Electronic address: bianpingda@hotmail.com.
Pingda
P
Bian
Department of Epidemiology & Health Statistics, Zhejiang University, Hangzhou, China.
Xiuyang
X
Li
Center for Diagnosis and Treatment of Osteoporosis, Zhejiang Provincial People's Hospital, Hangzhou, China.
Qifeng
Q
Ying
Center for Diagnosis and Treatment of Osteoporosis, Zhejiang Provincial People's Hospital, Hangzhou, China.
Jinping
J
Chen
Department of Pharmaceutical Science, Zhejiang Provincial People's Hospital, Hangzhou, China.
Xue
X
Jin
Department of Medical Records and Statistics, Zhejiang Provincial People's Hospital, Hangzhou, China.
Jiong
J
Yao
Department of Pharmaceutical Science, Zhejiang Provincial People's Hospital, Hangzhou, China. Electronic address: shousor@126.com.
Zhangxuan
Z
Shou
D015502:Absorptiometry, Photon; D000369:Aged, 80 and over; D000375:Aging; D044466:Asian People / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D024042:Collagen Type I / Q000097:blood; D015897:Comorbidity; D004958:Estradiol / Q000097:blood; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000208:ethnology / Q000209:etiology; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology / Q000209:etiology
D015415:Biomarkers; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D004958:Estradiol
Bone mineral density; Femoral neck; Very elderly male