Results of hepatic and renal function tests to different CO2 pneumoperitoneum conditions: An experimental capnoperitoneum study in dogs.
Carbon dioxide (CO2) is the most commonly used insufflation gas to provide exposure in the abdominal cavity during laparoscopic surgery. This study investigated the results of hepatic and renal function tests after different capnoperitoneum intraabdominal pressures in dogs. Twenty-four beagle dogs (12 males and 12 females) were used (n = 6 dogs). The intraabdominal pressure was maintained for 60 minutes, and urinalysis, hepatic and renal function tests were carried out at designed times. No surgery was performed on any of the dogs during the capnoperitoneum. In this study, whether low or high pressure, significant increases of gamma-glutamyltransferase, alkaline phosphatase, aspartate aminotransferase and creatinine levels were observed after pneumoperitoneum. However, our results showed a trend toward higher serum concentrations of some enzymes in dogs at an insufflation pressure of 15 mmHg compared to that of the other groups, although these differences did not reach statistical significance. Therefore, low pressure capnoperitoneum should be considered for dogs with compromised splanchnic function, particularly those undergoing prolonged laparoscopic surgery.
Veterinary Medical Center, Chungbuk National University, Cheogju 361-763, Republic of Korea. Electronic address: romanavet@hanmail.net.
Jae Yeon
JY
Lee
Veterinary Medical Center, Chungbuk National University, Cheogju 361-763, Republic of Korea.
Seok Hwa
SH
Choi
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002245:Carbon Dioxide / Q000008:administration & dosage*; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005260:Female; D007274:Injections, Intraperitoneal / Q000662:veterinary; D007668:Kidney / Q000502:physiology*; D010535:Laparoscopy / Q000379:methods / Q000662:veterinary*; D008099:Liver / Q000502:physiology*; D008297:Male; D011028:Pneumoperitoneum, Artificial / Q000379:methods / Q000662:veterinary*; D011312:Pressure / Q000009:adverse effects*; D005723:gamma-Glutamyltransferase / Q000097:blood
D002245:Carbon Dioxide; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase
Capnoperitoneum; Dogs; Hepatic and renal function; Intraabdominal pressure