The IL-33/ST2 axis: Role in health and disease.
IL-33, an IL-1 family member, is expressed by many cell types and can regulate gene transcription. IL-33 is released upon cell necrosis and the precursor form is enzymatically processed, and then drives inflammation as a damage-associated molecular pattern. The IL-33 receptor ST2, encoded by IL1RL1, is expressed as both a membrane-anchored receptor (ST2L) activated by IL-33, and as a soluble variant (sST2) that exhibits anti-inflammatory properties. The IL-33/ST2 axis is involved in the pathogenesis of atopic and autoimmune diseases, cancer, and central nervous system disorders. Here, we review recent findings on the role of the IL-33/ST2 axis in health and disease.
Disciplinary Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, CL 8380453, Chile; Gastroenterology Department, Clinical Las Condes, Santiago, Chile.
Marjorie
M
De la Fuente
Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK.
Thomas T
TT
MacDonald
Disciplinary Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, CL 8380453, Chile. Electronic address: mhermoso@med.uchile.cl.
Marcela A
MA
Hermoso
D000818:Animals; D015551:Autoimmunity; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000503:physiopathology; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D012871:Skin Diseases / Q000276:immunology* / Q000503:physiopathology
C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D011956:Receptors, Cell Surface
Autoimmunity; IL-33; Inflammatory bowel diseases; ST2; Table of contents