Branched/linear selectivity in palladium-catalyzed allyl-allyl cross-couplings: The role of ligands.
While Pd-catalyzed allyl-allyl cross-couplings in the presence of small-bite-angle bidentate ligands reliably furnish the branched regioisomer with high levels of selectivity, cross-couplings in the presence of large-bite-angle bidentate ligands give varying, often unpredictable, levels of selectivity. In a combined computational and experimental study, we probe the underlying features that govern the regioselectivity in these metal-catalyzed cross-couplings.
Department of Chemistry, Boston College, Chestnut Hill, MA 02467.
Michael J
MJ
Ardolino
Department of Chemistry, Boston College, Chestnut Hill, MA 02467.
James P
JP
Morken
Allylation; Bite Angle; Cross-coupling; Pd catalysis