Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report.
We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturbances, eventually leading to death. MRI imaging pattern was unique and attributable to fludarabine neurotoxicity.
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
Claudio
C
Annaloro
Neuroradiology Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
Antonella
A
Costa
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
Nicola S
NS
Fracchiolla
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
Gabriella
G
Mometto
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
Silvia
S
Artuso
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
Giorgia
G
Saporiti
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
Elena
E
Tagliaferri
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
Federica
F
Grifoni
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy ; Faculty of Medicine, University of Milan Milan, Italy.
Francesco
F
Onida
Hematology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy ; Faculty of Medicine, University of Milan Milan, Italy.
Agostino
A
Cortelezzi
Fludarabine; hematopoietic stem cell transplantation; neurotoxicity