Enhanced cellular uptake of nanoparticles by increasing the hydrophobicity of poly(lactic acid) through copolymerization with cell-membrane-lipid components.
The influence of hydrophobicity on the internalization of polymeric nanoparticles (NPs) remains poorly investigated. The hydrophobicity of poly(L-lactide) was increased by copolymerization with cell-membrane-lipid components, and this significantly enhanced the uptake of NPs up to 60% in the human cervical cancer cell line in comparison to unmodified poly(L-lactide) NPs.
Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier-Str. 31, 79104 Freiburg, Germany. prasad.shastri@gmail.com.
Mariam
M
Samadi Moghaddam
Markus
M
Heiny
V Prasad
VP
Shastri
D002462:Cell Membrane / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D019344:Lactic Acid / Q000737:chemistry*; D008563:Membrane Lipids / Q000378:metabolism*; D053758:Nanoparticles; D011091:Polyesters; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
D008563:Membrane Lipids; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)