ROLE OF RS9939609 FTO GENE VARIANT IN WEIGHT LOSS, INSULIN RESISTANCE AND METABOLIC PARAMETERS AFTER A HIGH MONOUNSATURATED VS A HIGH POLYUNSATURATED FAT HYPOCALORIC DIETS.
BACKGROUND
common polymorphisms (rs9939609) of the fat mass and obesity associated gene (FTO) have been linked to obesity.


OBJECTIVE
our aim was to investigate the role of this polymorphism on insulin resistance, metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diets.


METHODS
a sample of 233 obese subjects was enrolled in a prospective way. In the basal visit, patients were randomly allocated during 3 months to; Diet M (high monounsaturated fat hypocaloric diet) or Diet P (high polyunsaturated fat hypocaloric diet).


RESULTS
after treatment with two diets and in both genotypes, weight, fat mass and waist circumference decreased. Lower levels of body mass index (BMI), weight and fat mass were detected after Diet P in A allele carriers than TT genotype subjects. With the diet type P and in both genotypes (TT and AT + AA), total cholesterol levels (-15.3 + 35.1 mg/dl vs -11.6 + 32.1 mg/dl: p > 0.05) and LDL cholesterol levels (-11.5 + 34.1 mg/dl vs -8.5 + 30.1 mg/dl: p > 0.05) decreased. In A allele carriers a significant decreased was detected in insulin levels (-2.8 + 2.1 UI/L vs -1.3 + 8.0 UI/L: p < 0.05) and HOMA index (-1.0 + 1.3 vs -0.2 + 2.1: p > 0.05), too. With the diet M and in both genotype groups, leptin levels (-8.0 + 17.1 ng/ ml vs -4.9 + 18.7 ng/ml: p > 0.05) decreased. Conclusiones: metabolic improvement secondary to weight loss was better in A carriers with a high polyunsaturated fat hypocaloric diet.
Svo de Endocrinología y Nutrición Hospital Clínico Universitario de Valladolid, Valladolid, Spain.. redactor04@nutricionhospitalaria.com.
Daniel Antonio
DA
De Luis
Svo de Endocrinología y Nutrición Hospital Clínico Universitario de Valladolid, Valladolid, Spain.. redactor04@nutricionhospitalaria.com.
Rocío
R
Aller
Svo de Endocrinología y Nutrición Hospital Clínico Universitario de Valladolid, Valladolid, Spain.. redactor04@nutricionhospitalaria.com.
Olatz
O
Izaola
Svo de Endocrinología y Nutrición Hospital Clínico Universitario de Valladolid, Valladolid, Spain.. redactor04@nutricionhospitalaria.com.
D
D
Pacheco
D000328:Adult; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D000886:Anthropometry; D015415:Biomarkers; D001835:Body Weight; D059305:Diet, High-Fat; D004734:Energy Metabolism / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D015431:Weight Loss / Q000235:genetics*
D015415:Biomarkers; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO