Aldosterone-to-renin ratio acts as the predictor distinguishing the primary aldosteronism from chronic kidney disease.
Aldosterone-to-renin ratio (ARR) is a screening test for primary aldosteronism, but it was impacted by a bunch of clinical covariates. The ARR is associated with chronic kidney disease (CKD), renal artery stenosis, renin adenoma. This study aims to investigate relationship between ARR and primary aldosteronism in CKD patients. A retrospective observational analysis involves 253 attendees from Urology Department of Chengdu Military General Hospital (China), comprising 146 patients with confirmed primary aldosteronism, 56 patients with essential hypertension, and 55 patients with chronic kidney disease accounting for primary kidney disease. Blood samples were drawn from patients with particular restriction for measuring serum aldosteronism, plasma renin activity, and serum potassium. Receiver operating characteristic (ROC) curve of ARR was tested to establish cutoff values and to assess sensitivity and specificity. The results showed that LogARR values were significantly higher (P < 0.001), and PRA and serum potassium values were significantly lower (P < 0.001) in primary aldosteronism patients. By contrast, significantly higher serum aldosterone and plasma renin were observed in CKDs compared with the other two groups (P < 0.001). There was a significantly positive correlation between LogARR and serum potassium (r = -0.0345, P < 0.001, R(2) = 0.093). The AUC for plasma renin activity, logARR, and serum aldosterone are 0.855, 0.84, and 0.501, respectively. ROC curve of logARR and plasma renin activity in detection of primary aldosteronism with higher sensitivity and specificity. In conclusion, this study indicated that the ARR act as the biomarker for the primary aldosteronism, and could distinguish from chronic kidney disease.
Department of Urology, Chengdu Military General Hospital Chengdu 610083, China.
Wei-Guo
WG
Chen
Department of Urology, Chengdu Military General Hospital Chengdu 610083, China.
Ting-Ting
TT
Zhou
Department of Urology, Chengdu Military General Hospital Chengdu 610083, China.
Peng
P
Zhou
Department of Urology, Chengdu Military General Hospital Chengdu 610083, China.
Xiao-Wei
XW
Li
Department of Urology, The First Affiliated Hospital of Xiamen University Xiamen 361003, China.
Zhun
Z
Wu
Department of Urology, The First Affiliated Hospital of Xiamen University Xiamen 361003, China.
Kai-Yan
KY
Zhang
Department of Urology, The First Affiliated Hospital of Xiamen University Xiamen 361003, China.
Jin-Chun
JC
Xing
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood*; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002648:Child; D002681:China; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis*; D012083:Renin / Q000097:blood*; D012189:Retrospective Studies; D055815:Young Adult
D015415:Biomarkers; D000450:Aldosterone; D012083:Renin
Aldosterone-to-renin ratio (ARR); chronic kidney disease; primary aldosteronism; receiver operating characteristic (ROC) curve