Granulocyte-colony stimulating factor (G-CSF) producing malignant pleural mesothelioma: Report of a case.
This report presents a case of malignant pleural mesothelioma (MPM) producing granulocyte colony-stimulating factor (G-CSF) that was treated by tumor resection. A 76-year-old male presented with a huge right-side chest wall tumor, along with a slight fever and chest wall pain. Laboratory findings showed an increased white blood cell count (64600 cells/μL) and C-reactive protein level (20.57 mg/dL). The patient underwent surgical removal of the tumor along with tissue from the chest wall and histopathological analysis led to a diagnosis of sarcomatous type of MPM. Immunohistochemical findings for both anti-human G-CSF and interleukin-6 monoclonal antibodies were positive. Although the general condition of the patient quickly improved after surgery, local recurrence occurred two months later and he died of respiratory failure seven months after the operation, though surgery provided symptom relief. G-CSF-producing MPMs usually show a poor prognosis, though less-invasive surgery may be considered for relief of symptoms.
Department of General Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka, Japan.
Ayako
A
Fujiwara
Department of General Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka, Japan.
Masahiko
M
Higashiyama
Department of General Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka, Japan.
Takashi
T
Kanou
Department of General Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka, Japan.
Jiro
J
Okami
Department of General Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka, Japan.
Toshiteru
T
Tokunaga
Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka, Japan.
Yasuhiko
Y
Tomita
Department of General Thoracic Surgery, Yao Municipal Hospital Yao, Japan.
Ken
K
Kodama
Granulocyte-colony stimulating factor (G-CSF); leukocytosis; malignant pleural mesothelioma; resection