New Clues that May Link Osteoporosis to the Circulating Lipid Profile.
Bone Mineral Density (BMD) is a gold standard for the diagnosis of osteoporosis and is also important in the assessment of fracture risk. Other risk factors have been identified that together make up fracture risk assessment tools such as FRAX. Another potential factor, circulating lipids, has been suggested because of reports linking statins to fracture risk reduction. We analyzed the lipid profile in a cohort of women diagnosed with postmenopausal osteoporosis based on bone density determination: 610 women with osteoporosis (mean lumbar spine T-score -3.16±0.81, mean yrs. since menopause 15.79±8.9) were grouped according to age at evaluation (< 50 years, 51-60 years, 61-70 years, > 70 years), the presence/absence of a history of a fragility fracture, statin and/or antiresorptive drug use. There was no correlation between BMD and Body Mass Index (BMI: P>0.05, r (2)<0.02). However, when BMD was correlated with both BMI and the lipid profile (Triglycerides, Cholesterol, LDLc, HDLc), significant correlations were found in 5 cohorts: 51-60 years with fractures (n=61, r (2)=0.14, P<0.01), 61-70 years (n=201, r (2)=0.09, P<0.01) with fractures (n=88, r (2)=0.14, P<0.01) or without fractures (n=113, r (2)=0.24, P=0.02) and over 70 years (n=247, r (2)=0.11, P<0.01).
"C. I. Parhon" National Institute of Endocrinology, Bucharest , Bucharest, Romania ; University of Medicine and Pharmacy "Carol Davila", Bucharest , Bucharest, Romania.
Catalina
C
Poiana
University of Medicine and Pharmacy "Carol Davila", Bucharest , Bucharest, Romania.
Valentin
V
Radoi
"C. I. Parhon" National Institute of Endocrinology, Bucharest , Bucharest, Romania ; University of Medicine and Pharmacy "Carol Davila", Bucharest , Bucharest, Romania.
Mara
M
Carsote
College of Physicians and Surgeons, Columbia University , New York, NY USA.
John P
JP
Bilezikian
HDL-cholesterol; bone mineral density; cholesterol; lipid; osteoporosis; triglycerides