Synthetic biology of fungal natural products.
Synthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product (NP) discovery and production. Until now, different aspects of synthetic biology have been covered in fungal NP studies from the manipulation of different regulatory elements and heterologous expression of biosynthetic pathways to the engineering of different multidomain biosynthetic enzymes such as polyketide synthases or non-ribosomal peptide synthetases. The following review will cover some of the exemplary studies of synthetic biology in filamentous fungi showing the capacity of these eukaryotes to be used as model organisms in the field. From the vast array of different NPs produced to the ease for genetic manipulation, filamentous fungi have proven to be an invaluable source for the further development of synthetic biology tools.
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute , Jena, Germany ; Institute for Microbiology, Friedrich Schiller University , Jena, Germany.
Derek J
DJ
Mattern
Leibniz Junior Research Group "Biobricks of Microbial Natural Product Syntheses" , Jena, Germany.
Vito
V
Valiante
School of Biology, Biomedical Sciences Research Complex, University of St Andrews , St Andrews, UK.
Shiela E
SE
Unkles
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute , Jena, Germany ; Institute for Microbiology, Friedrich Schiller University , Jena, Germany.
Axel A
AA
Brakhage
engineering of biosynthetic enzymes; fungal natural products; heterologous expression; regulation of natural products; synthetic biology