IMMUNE RESPONSE OF SEVERE MALNUTRITION CHILDREN TREATED ACCORDING TO THE PROTOCOL OF THE WORLD HEALTH ORGANIZATION.
The aim of the study was to compare the innate immune system of severely malnourished children admitted to the Instituto de Medicina Integral Professor Fernando Figueira and treated according to the protocol of the World Health Organization (WHO) at admission and discharge. An experimental study was conducted with 20 children under two years of age. Ten of them had severe malnutrition and ten were a control group. The malnourished group consisted of hospitalized infants and it was submitted to WHO's protocol. Children with HIV and re-admitted during the study period were excluded. A blood sample was taken at admission and at discharge. Later, an analysis of blood leukocytes, adherence index, phagocytic capacity, production of free radicals superoxide and nitric oxide was performed. Patients with severe malnutrition at hospital discharge showed improved phagocytic function, release of oxygen radicals and reduction of the number of lymphocytes when compared to the time of admission. When compared to the control group, patients at hospital discharge had lower lymphocyte values and lower production of free radicals. Thus, it can be concluded that the duration of hospitalization was insufficient to restore cell-mediated immunity and microbicide activity.
Department of Nutrition, Federal University of Pernambuco.. rebecca.peixoto@gmail.com.
Rebecca
R
Peixoto Paes-Silva
Department of Nutrition, Federal University of Pernambuco.. rebecca.peixoto@gmail.com.
Érika Michelle
ÉM
Correia de Macedo
Department of Nutrition, Federal University of Pernambuco.. rebecca.peixoto@gmail.com.
Marília Tokiko
MT
Oliveira Tomiya
Laboratory of Microbiology and Cells Culture of Laboratório de Imunopatologia Keizo Asami - LIKA, Federal University of Pernambuco, Brazil.. rebecca.peixoto@gmail.com.
Célia Maria
CM
Machado Barbosa de Castro
D015415:Biomarkers; D002448:Cell Adhesion; D015362:Child Nutrition Disorders / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D002675:Child, Preschool; D006801:Humans; D007109:Immunity; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D009569:Nitric Oxide; D010587:Phagocytosis; D017410:Practice Guidelines as Topic; D012720:Severity of Illness Index; D014944:World Health Organization
D015415:Biomarkers; D009569:Nitric Oxide