HEPATIC FATTY ACID PROFILE OF RATS FED A TRIHEPTANOIN-BASED KETOGENIC DIET.
OBJECTIVE
the aim of this study was to evaluate the influence of consumption of a ketogenic diet supplemented with triheptanoin, a medium-chain anaplerotic triacylglycerol, on the liver fatty acid profile of Wistar rats.


METHODS
three groups of male Wistar rats (n = 10) were submitted to an AIN-93 control diet, a triheptanoin- based ketogenic diet, or a soybean oil-based ketogenic diet for 60 days. Excised livers were subjected to lipid extraction and methylation to obtain fatty acids methyl esters, which were subjected to gas chromatography- mass spectrometry.


CONCLUSIONS
compared to the rats fed the control diet, those fed ketogenic diets showed a significant reduction in the concentrations of 9-hexadecenoic and 9-octadecenoic acids, whereas those fed triheptanoin showed increased levels of octadecanoic acid.


CONCLUSIONS
changes in the liver fatty acid profiles of the rats fed a triheptanoin-based or a soybean oil-based ketogenic diet did not seem to be related to the dietary fat source, but rather to the characteristics of the ketogenic diets themselves.
Departamento de Agroindústria, Instituto Federal de Educação Ciência e Tecnologia de Alagoas, Murici, AL.. ingridsofia_melo@hotmail.com.
Ingrid Sofia
IS
Vieira de Melo
Laboratório de Nutrição Experimental, Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL.. ingridsofia_melo@hotmail.com.
Terezinha
T
Da Rocha Ataide
Laboratório de Nutrição Experimental, Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL.. ingridsofia_melo@hotmail.com.
Suzana
S
Lima de Oliveira
Laboratório de Nutrição Experimental, Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL.. ingridsofia_melo@hotmail.com.
Nassib
N
Bezerra Bueno
Departamento de Tecnologia de Alimentos, Instituto Federal de Educação Ciência e Tecnologia de Alagoas, Maceió - AL.. ingridsofia_melo@hotmail.com.
Johnnatan
J
Duarte de Freitas
Laboratório de Recursos Naturais, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brasil.. ingridsofia_melo@hotmail.com.
Antônio Euzébio
AE
Goulart Sant'Ana
D000818:Animals; D055423:Diet, Ketogenic; D019587:Dietary Supplements; D005227:Fatty Acids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D055432:Metabolomics / Q000379:methods; D051381:Rats; D014280:Triglycerides / Q000008:administration & dosage*
D005227:Fatty Acids; D014280:Triglycerides; C531010:triheptanoin