Recent advancement of gelatin nanoparticles in drug and vaccine delivery.
Novel drug delivery system using nanoscale materials with a broad spectrum of applications provides a new therapeutic foundation for technological integration and innovation. Nanoparticles are suitable drug carrier for various routes of administration as well as rapid recognition by the immune system. Gelatin, the biological macromolecule is a versatile drug/vaccine delivery carrier in pharmaceutical field due to its biodegradable, biocompatible, non-antigenicity and low cost with easy availability. The surface of gelatin nanoparticles can be modified with site-specific ligands, cationized with amine derivatives or, coated with polyethyl glycols to achieve targeted and sustained release drug delivery. Compared to other colloidal carriers, gelatin nanoparticles are better stable in biological fluids to provide the desired controlled and sustained release of entrapped drug molecules. The current review highlights the different formulation aspects of gelatin nanoparticles which affect the particle characteristics like zeta potential, polydispersity index, entrapment efficacy and drug release properties. It has also given emphasis on the major applications of gelatin nanoparticles in drug and vaccine delivery, gene delivery to target tissues and nutraceutical delivery for improving the poor bioavailabity of bioactive phytonutrients.
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032.
Nityananda
N
Sahoo
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032.
Ranjan Ku
RK
Sahoo
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032.
Nikhil
N
Biswas
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032.
Arijit
A
Guha
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032. Electronic address: ketousetuoju@yahoo.in.
Ketousetuo
K
Kuotsu
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D005780:Gelatin / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D013499:Surface Properties; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology
D004337:Drug Carriers; D014612:Vaccines; D005780:Gelatin
Entrapment efficacy; Gelatin nanoparticles; Vaccine delivery