[Apa1 VDR polymorphism and osteoporosis risk in postmenopausal Mexican women].
OBJECTIVE
To analyze the association between Apa1 VDR polymorphism and osteoporosis in Mexican mestizo postmenopausal women.


METHODS
A cross-sectional study was conducted in 534 postmenopausal mestizo women from Mexico City to determine the association of the Apa1 Vitamin D Receptor gene polymorphism (rs7975232) with osteoporosis and osteoporosis plus fracture. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry. Genotyping was performed using real-time PCR with an allelic discrimination assay.


RESULTS
The Apa1 allele frequencies were no different between groups. No association was found between Apa1 genotypes and osteoporosis (AA, OR: 1.08; 95% CI: 0.62-1.87; AC, OR: 0.70; 95% CI: 0.45-1.07). Similar results were obtained for osteoporosis plus fracture (AA, OR: 0.93; 95% CI: 0.50-1.71; AC, OR: 0.70; 95% CI 0.45-1.07). After adjusting for age, the result remained.


CONCLUSIONS
These findings are in agreement with previous studies reporting no association of Apa1 VDR polymorphism with osteoporosis.
Unidad de Epidemiología Clínica, Hospital Infantil de México Federico Gómez, México, D.F., México.|Departamento de Farmacología, Cinvestav-IPN.
Osvaldo D
OD
Castelán-Martínez
Unidad de Epidemiología Clínica, Hospital Infantil de México Federico Gómez, México, D.F., México.
Nalleli
N
Vivanco-Muñoz
Servicio de Genética, Instituto Nacional de Rehabilitación, México, D.F., México.
Edith
E
Falcón-Ramírez
Servicio de Genética, Instituto Nacional de Rehabilitación, México, D.F., México.
Margarita
M
Valdés-Flores
Unidad de Epidemiología Clínica, Hospital Infantil de México Federico Gómez, México, D.F., México.|Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, D.F., México.
Patricia
P
Clark
D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D017698:Postmenopause; D018167:Receptors, Calcitriol / Q000235:genetics*; D018570:Risk Assessment; D014157:Transcription Factors / Q000235:genetics*
D018167:Receptors, Calcitriol; D014157:Transcription Factors; C467905:ZNF410 protein, human