Real Time Dual-Channel Multiplex SERS Ultradetection.
Surface-enhanced Raman scattering (SERS) can be combined with microfluidics for rapid multiplex analyte screening. Through combination of the high intensity and complex signals provided by SERS with the flow characteristics of microfluidic channels, we engineered a microdevice that is capable of monitoring various analytes from different sources in real time. Detection limits down to the nM range may allow the generation of a new family of devices for remote, real time monitoring of environmental samples such as natural or waste waters and application to the high-throughput screening of multiple samples in healthcare diagnostics.
†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.|‡Department of Physical Chemistry, Universidade de Vigo, Vigo, Spain.
Sara
S
Abalde-Cela
†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Chris
C
Abell
∥Departamento de Quimica Fisica e Inorganica, Universitat Rovira i Virgili and Centro de Tecnologia Quimica de Cataluña, Carrer de Marcel·lı́ Domingo s/n, 43007 Tarragona, Spain.|§ICREA, Passeig Lluı́s Companys 23, 08010 Barcelona, Spain.
Ramón A
RA
Alvarez-Puebla
‡Department of Physical Chemistry, Universidade de Vigo, Vigo, Spain.|⊥Bionanoplasmonics Laboratory, CIC biomaGUNE, Paseo de Miramón 182, 20009 Donostia - San Sebastián, Spain.|#Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain.
Luis M
LM
Liz-Marzán
SERS; microfluidics; multiplex; real time detection