[Cellular model of blood coagulation process].
Blood coagulation is a process which main objective is the prevention of blood loss when the integrity of the blood vessel is damaged. Over the years, have been presented a number of concepts characterizing the mechanism of thrombus formation. Since the 60s of last century was current cascade model of the coagulation wherein forming of the fibrin clot is determined by two pathways called extrinsic and intrinsic pathways. In the nineties of the last century Monroe and Hoffman presented his concept of blood coagulation process which complement the currently valid model of cells participation especially of blood platelets which aim is to provide a negatively charged phospholipid surface and thereby allow the coagulation enzymatic complexes formation. Developed conception they called cellular model of coagulation. The aim of this work was to present in details of this blood coagulation, including descriptions of its various phases.
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Poland.
Michał
M
Bijak
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Poland.
Paulina
P
Rzeźnicka
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Poland.
Joanna
J
Saluk
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Poland.
Paweł
P
Nowak
D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010743:Phospholipids / Q000378:metabolism; D013499:Surface Properties
D001779:Blood Coagulation Factors; D010743:Phospholipids
blood coagulation; blood platelets; hemostasis