Luteal phase support in intrauterine insemination cycles: a prospective randomized study of 300 mg versus 600 mg intravaginal progesterone tablet.
Vaginal progesterone (P) has been suggested to be used for luteal phase support (LPS) in controlled ovarian stimulation (COH)-intrauterine insemination (IUI) cycles, however, no concensus exists about the best P dose. Therefore, considering the fecundability rate as the primary end point, our main objective was to find the optimal dose of P in COH-IUI cycles, comparing the two groups of women, each of which comprised of 100 women either on 300 mg or 600 mg of intravaginal P tablets, in a prospective randomized study design. The mean age of the women, duration of infertility, basal and day of hCG injection hormone levels in the female and sperm parameters were similar in the two study groups. Also, duration and dose of gonadotropin given, number of follicles, endometrial thickness, the total, ongoing and multiple pregnancy rates were comparable in both groups. We, therefore, claim that 300 mg of intravaginal micronized P should be the maximum dose of LPS in IUI cycles.
a Dr. Zekai Tahir Burak Women Health Care, Education and Research Hospital , Ankara , Turkey .
Ebru H
EH
Biberoglu
b Araklı Bayram Halil Hospital , Trabzon , Turkey , and.
Filiz
F
Tanrıkulu
c Department of Obstetrics and Gynecology , Gazi University Medical School , Ankara , Turkey.
Mehmet
M
Erdem
c Department of Obstetrics and Gynecology , Gazi University Medical School , Ankara , Turkey.
Ahmet
A
Erdem
c Department of Obstetrics and Gynecology , Gazi University Medical School , Ankara , Turkey.
Kutay Omer
KO
Biberoglu
D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D008183:Luteal Phase; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage*; D011372:Progestins / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
D011372:Progestins; D011374:Progesterone
Controlled ovarian stimulation; corpus luteum deficiency; fecundability rate; ongoing pregnancy rate; unexplained infertility