OPN -Revisited.
Osteopontin (OPN), a matrix extracellular glyco-phosphoprotein is found in various tissues such as epithelium lined tissues, kidney, bone and teeth .It is also detected in all body fluids including blood and breast milk. OPN plays role in a number of physiological and pathologic events such as cell adhesion, migration and cell survival, angiogenesis, apoptosis, inflammation and wound healing. This review summarizes the current data of the biological activities of OPN in the development of tumour, its progression and metastasis.
Senior Lecturer, Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, Sri Ramachandra University , Porur, Chennai, India .
Vijayanirmala
V
Subraman
Associate Professor, Department of Anatomy, Sri Ramachandra University , Porur, Chennai, India .
Muthukumar
M
Thiyagarajan
Professor and Head, Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, Sri Ramachandra University , Porur, Chennai, India .
N
N
Malathi
Reader, Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, Sri Ramachandra University , Porur, Chennai, India .
Sharada T
ST
Rajan
Angiogenesis; Cell adhesion; Metastasis; Osteopontin