Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies.
A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.
Institute for Research in Biomedicine (IRB Barcelona), 08028, Barcelona, Spain.
Pau
P
Rocas
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering and Centre for Research in NanoEngineering (CRNE), Technical University of Catalonia (UPC), 08028, Barcelona, Spain.|Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08028, Barcelona, Spain.
Mireia
M
Hoyos-Nogués
Nanobiotechnological Polymers Division, Ecopol Tech S.L., 43720, L'Arboç, Tarragona, Spain.
Josep
J
Rocas
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering and Centre for Research in NanoEngineering (CRNE), Technical University of Catalonia (UPC), 08028, Barcelona, Spain.|Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08028, Barcelona, Spain.
José M
JM
Manero
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering and Centre for Research in NanoEngineering (CRNE), Technical University of Catalonia (UPC), 08028, Barcelona, Spain.|Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08028, Barcelona, Spain.
Javier
J
Gil
Institute for Research in Biomedicine (IRB Barcelona), 08028, Barcelona, Spain.|Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08028, Barcelona, Spain.|Department of Organic Chemistry, University of Barcelona, 08028, Barcelona, Spain.|School of Chemistry & Physics, University of Kwazulu-Natal, Durban, 4001, South Africa.|School of Chemistry, Yachay Tech, Yachay City of Knowledge, 100119, Urcuquí, Ecuador.
Fernando
F
Albericio
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering and Centre for Research in NanoEngineering (CRNE), Technical University of Catalonia (UPC), 08028, Barcelona, Spain.|Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08028, Barcelona, Spain.
Carlos
C
Mas-Moruno
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry; D015575:Roxithromycin / Q000737:chemistry* / Q000494:pharmacology; D013298:Streptococcus sanguis / Q000187:drug effects; D014025:Titanium / Q000737:chemistry
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D009842:Oligopeptides; D011108:Polymers; D011140:Polyurethanes; D015575:Roxithromycin; C045786:polyurea; C047981:arginyl-glycyl-aspartic acid; D014025:Titanium
RGD peptides; antibacterial properties; multifunctional nanomaterials; surface functionalization; titanium osseointegration