Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids.
The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.
Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain. jccedron@hotmail.com.|Departamento de Ingeniería Química Industrial, Universidad de Ingeniería & Tecnología (UTEC), Av. Cascanueces 2221 Santa Anita, Lima 43, Peru. jccedron@hotmail.com.
Juan C
JC
Cedrón
Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain. agravelo@ull.es.|Departamento de Química Orgánica, Universidad de La Laguna, La Laguna 38206, Spain. agravelo@ull.es.
Ángel G
ÁG
Ravelo
Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain. lgleon@ull.edu.es.
Leticia G
LG
León
Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain. jmpadron@ull.es.
José M
JM
Padrón
Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain. aestebra@ull.es.|Departamento de Química Orgánica, Universidad de La Laguna, La Laguna 38206, Spain. aestebra@ull.es.
Ana
A
Estévez-Braun
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D019668:Liliaceae / Q000737:chemistry; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic
Amarylidaceae alkaloids; SAR; antiproliferative activity