Copper catalyzed oxygen assisted C(CNOH)-C(alkyl) bond cleavage: a facile conversion of aryl/aralkyl/vinyl ketones to aromatic acids.
A novel copper-catalyzed aerobic oxidative C(NOH)-C(alkyl) bond cleavage reaction of aryl/aralkyl/vinyl ketones for the synthesis of aromatic/acrylic acids is described. A series of ketones having aryl/aralkyl/vinyl at the one end and methyl to any higher alkyl at the other end can be selectively cleaved and converted into the corresponding acids via oxime intermediates.
Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, India. bsreddy@iict.res.in.
Pochampalli
P
Sathyanarayana
Owk
O
Ravi
Prathap Reddy
PR
Muktapuram
Surendar Reddy
SR
Bathula
D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*
D000179:Acrylates; D007659:Ketones; D003300:Copper; C036658:acrylic acid; D010100:Oxygen