Estrogen receptor beta gene polymorphisms and risk of recurrent pregnancy loss: a case-control study.
Estrogen might play a key role in the maintenance of pregnancy. We investigated the role of the ER-β gene +1730 G/A, +1082 G/A, and CA repeat polymorphisms in Korean patients with recurrent pregnancy loss (RPL). Genotyping was performed using the TaqMan assay in 305 patients with at least two unexplained consecutive spontaneous miscarriages before 20 weeks of gestation and 299 controls. The genotype distributions of the ER-β gene +1082 G/A and +1730 G/A polymorphisms in the RPL group did not differ from those in the control group. When the analysis was restricted to patients with three or more consecutive spontaneous miscarriages, there were also no differences in the genotype distribution between this subgroup and controls. The number of CA repeats was distributed from 13 to 28 with two large peaks at 18 and 23 in patients with RPL and controls. Using the two major peaks as cut-offs, the allele distributions were compared between patients and controls. However, the distribution of ER-β gene CA repeats did not differ between women with recurrent miscarriage and controls. Findings of the current study suggest that the ER-β gene polymorphisms are not major determinants of the development of RPL in Korean women.
a Department of Obstetrics and Gynecology , Healthcare System Gangnam Center, Seoul National University Hospital , Seoul , Korea .|b The Institute of Reproductive Medicine and Population, Medical Research Centre, Seoul National University College of Medicine , Seoul , Korea .
Jin Ju
JJ
Kim
b The Institute of Reproductive Medicine and Population, Medical Research Centre, Seoul National University College of Medicine , Seoul , Korea .|c Department of Obstetrics and Gynecology , Seoul National University College of Medicine , Seoul , Korea .
Young Min
YM
Choi
d Department of Obstetrics and Gynecology , Konyang University College of Medicine , Daejeon , Korea .
Sung Ki
SK
Lee
e Department of Obstetrics and Gynecology , Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine , Seoul , Korea .
Kwang Moon
KM
Yang
f Department of Obstetrics and Gynecology , Bundangcheil Women's Hospital , Bundang , Korea .
Eun Chan
EC
Paik
g Department of Obstetrics and Gynecology , Seoul Rachel Fertility Center , Seoul , Korea , and.
Hyeon Jeong
HJ
Jeong
c Department of Obstetrics and Gynecology , Seoul National University College of Medicine , Seoul , Korea .
Jong Kwan
JK
Jun
d Department of Obstetrics and Gynecology , Konyang University College of Medicine , Daejeon , Korea .
Ae Ra
AR
Han
h Department of Obstetrics and Gynecology , Seoul Municipal Boramae Hospital , Seoul , Korea.
Kyu Ri
KR
Hwang
c Department of Obstetrics and Gynecology , Seoul National University College of Medicine , Seoul , Korea .
Min A
MA
Hong
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D056910:Republic of Korea
C000600034:ESR2 protein, human; D047629:Estrogen Receptor beta
ER-β gene; habitual abortion; recurrent pregnancy loss; single-nucleotide polymorphism