Positive correlation between uric acid and C-reactive protein serum level in healthy individuals and patients with acute coronary syndromes.
OBJECTIVE
To assess serum levels and correlation between uric acid (UA) and C-reactive protein (CRP) in acute coronary syndrome (ACS) and apparently healthy individuals.


METHODS
The cross-sectional study included 116 examinees of age 44 to 83 years, distributed in two groups: 80 ACS patients including 40 with acute myocardial infarction (AMI), and 40 with unstable angina pectoris (UAP), and 36 apparently healthy (control group) individuals. Patients with ACS were hospitalized at the Cardiology Clinic, Clinical Centre Sarajevo in the period October- December 2012. Laboratory analyses were conducted by standard methods. The accepted statistical significance level was p<0.05.


RESULTS
Serum levels of CRP and UA were higher in patients with ACS as compared to control group (p<0.01). The median serum UA was insignificantly lower, and CRP was significantly higher in patients with AMI compared to UAP (p=0.118 and p=0.001, respectively). CRP and UA correlated positively in both ACS and control groups (rho=0.246; p=0.028 and rho=0.374; p=0.027). A positive correlation between serum CRP and UA was noted in patients with AMI, but negative in patients with UAP (p>0.05).


CONCLUSIONS
The correlation between CRP and UA in the patients with ACS indicates the association of oxidative stress and inflammation intensity in damaged cardiomyocytes. Correlation between UA and CRP in apparently healthy individuals indicates a possible role of UA as a marker of low-grade inflammation and its potential in risk assessment in cardiovascular diseases.
Primary Health Center Zenica, Bosnia and Herzegovina.
Emina
E
Spahić
Department of Medical Biochemistry, Faculty of Medicine University of Sarajevo; Bosnia and Herzegovina.
Sabaheta
S
Hasić
Department of Medical Biochemistry, Faculty of Medicine University of Sarajevo; Bosnia and Herzegovina.
Emina
E
Kiseljaković
Clinic for Hemodialysis, Clinical Center University of Sarajevo; Bosnia and Herzegovina.
Halima
H
Resić
Cardiology Clinic, Clinical Centre University of Sarajevo; Bosnia and Herzegovina.
Mehmed
M
Kulić
D054058:Acute Coronary Syndrome / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein
angina; inflammation; myocardial infarction; oxidative stress; unstable