TETs Link Hydrogen Sulfide to Immune Tolerance.
Demethylation of the Foxp3 locus maintains gene expression and Treg cell stability. Yang et al. (2015) show that the gasotransmitter hydrogen sulfide co-operates with growth factor TGF-β and interleukin-2 to activate Tet-mediated DNA demethylation of Foxp3 to promote immune tolerance.
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Soyoung A
SA
Oh
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: lim@mskcc.org.
Ming O
MO
Li
D000818:Animals; D003092:Colitis / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D011518:Proto-Oncogene Proteins; D006862:Hydrogen Sulfide