Skin tissue repair: Matrix microenvironmental influences.
The process of repair of wounded skin involves intricate orchestration not only between the epidermal and dermal compartments but also between the resident and immigrant cells and the local microenvironment. Only now are we beginning to appreciate the complex roles played by the matrix in directing the outcome of the repair processes, and how this impacts the signals from the various cells. Recent findings speak of dynamic and reciprocal interactions that occurs among the matrix, growth factors, and cells that underlies this integrated process. Further confounding this integration are the physiologic and pathologic situations that directly alter the matrix to impart at least part of the dysrepair that occurs. These topics will be discussed with a call for innovative model systems of direct relevance to the human situation.
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213 USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213 USA; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA. Electronic address: wellsa@upmc.edu.
Alan
A
Wells
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213 USA; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA.
Austin
A
Nuschke
Department of Health Development and Promotion, University of Pittsburgh, Pittsburgh, PA 15213 USA; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA.
Cecelia C
CC
Yates
D000818:Animals; D060833:Cellular Microenvironment; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D012867:Skin / Q000293:injuries*; D014945:Wound Healing
D036341:Intercellular Signaling Peptides and Proteins
Chronic wound; Collagen; Decorin; Extracellular matrix; Matrikine signaling; Skin organ cultures; Tenascin-C; Wound healing