EFFECT OF LONG TERM INTAKE OF WHITE TEA ON ACUTE OXIDATIVE STRESS IN RATS.
BACKGROUND
the well known antioxidant properties of white tea include the prevention of cancer, neurodegenerative diseases and oxidative stress. Adriamycin can generate an amount of oxidative stress in vivo.


OBJECTIVE
evaluate long term intake of white tea on plasma antioxidant capacity and on the fatty acid profile of liver and heart microsomes in animals subjected to acute oxidative stress.


METHODS
rats were given distilled water (controls), 15 mg/d (dose 1) or 45 mg/d (dose 2) of solid white tea extract/per kilogram of body weight for 12 months. After this time, all the animals received an injection of adriamycin (ADR) (10 mg/kg body weight), except half of the control group, which were given an injection of saline solution. Samples of plasma and liver and heart were taken. The antioxidant activity, the carbonyl groups and hydroperoxide concentration were analyzed in plasma, and the fatty acid profiles of liver and heart microsomes were obtained.


CONCLUSIONS
only the hydroperoxides showed significant changes, while slight tendencies were observed in antioxidant activity and the carbonyl groups. Although the long term intake of white tea and the administration of adriamycin did not change the fatty acid profile, slight tendencies existed for the SFAs, MUFAs and PUFAs.
Physiology Department, Faculty of Biology, University of Murcia, 30100 Murcia (Spain).. cespinosa31416@gmail.com.
Cristóbal
C
Espinosa
Physiology Department, Faculty of Biology, University of Murcia, 30100 Murcia (Spain).. cespinosa31416@gmail.com.
Daniel
D
González-Silvera
Physiology Department, Faculty of Biology, University of Murcia, 30100 Murcia (Spain).. cespinosa31416@gmail.com.
Francisca
F
Pérez-Llamas
Physiology Department, Faculty of Biology, University of Murcia, 30100 Murcia (Spain).. cespinosa31416@gmail.com.
José Ángel
JÁ
López-Jiménez
Physiology Department, Faculty of Biology, University of Murcia, 30100 Murcia (Spain).. sazana@um.es.
Salvador
S
Zamora
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D013662:Tea / Q000737:chemistry
D000975:Antioxidants; D005227:Fatty Acids; D008055:Lipids; D013662:Tea; D006861:Hydrogen Peroxide