Aspheric versus wavefront-guided photorefractive keratectomy: contralateral eye study.
OBJECTIVE
To compare the refractive, visual, and aberrometric outcomes between wavefront-guided photorefractive keratectomy (PRK) and aspheric PRK in myopic patients.


METHODS
Khatam-al-Anbia Eye Hospital, Mashhad, Iran.


METHODS
Prospective randomized clinical trial.


METHODS
One eye of each patient was randomly assigned to excimer laser wavefront-guided PRK (Zyoptix) and the other eye to excimer laser aspheric PRK (Technolas 217z). The preoperative and 3-month and 6-month postoperative refractive errors, visual acuity, contrast sensitivity, and higher-order aberrations (HOAs) were compared between the groups.


RESULTS
Ninety-six eyes (48 patients) were enrolled. At the last postoperative visit, there were no between-group differences in uncorrected distance visual acuity (UDVA) (P = .987) or corrected distance visual acuity (P = .416). The mean spherical equivalent was -0.076 diopter (D) ± 0.029 (SD) in the wavefront-guided group and -0.077 ± 0.075 D in the aspheric PRK group (P = .684). Postoperatively, the mean area under the log of contrast sensitivity function (AULCSF) with and without glare testing improved over preoperative values (both P < .001). There was no statistically significant between-group difference in the AULCSF with glare (P = .903) or without glare (P = .978). Total HOAs increased after PRK in both groups, although aspheric PRK induced fewer HOAs than wavefront-guided PRK (P = .04).


CONCLUSIONS
Both PRK methods equally improved postoperative UDVA and contrast sensitivity. The HOAs increased after treatment with both methods; however, aspheric ablation induced statistically fewer HOAs than wavefront-guided ablation.


BACKGROUND
No author has a financial or proprietary interest in any material or method mentioned.
From the Cornea Research Center (Zarei-Ghanavati, Gharaee), Mashhad University of Medical Sciences, Mashhad, and the Eye Research Center (Abrishami), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; the Laser Refractive Center (Hamilton, Sanchez), Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Siamak
S
Zarei-Ghanavati
From the Cornea Research Center (Zarei-Ghanavati, Gharaee), Mashhad University of Medical Sciences, Mashhad, and the Eye Research Center (Abrishami), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; the Laser Refractive Center (Hamilton, Sanchez), Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Hamid
H
Gharaee
From the Cornea Research Center (Zarei-Ghanavati, Gharaee), Mashhad University of Medical Sciences, Mashhad, and the Eye Research Center (Abrishami), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; the Laser Refractive Center (Hamilton, Sanchez), Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
David Rex
DR
Hamilton
From the Cornea Research Center (Zarei-Ghanavati, Gharaee), Mashhad University of Medical Sciences, Mashhad, and the Eye Research Center (Abrishami), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; the Laser Refractive Center (Hamilton, Sanchez), Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
P James
PJ
Sanchez
From the Cornea Research Center (Zarei-Ghanavati, Gharaee), Mashhad University of Medical Sciences, Mashhad, and the Eye Research Center (Abrishami), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; the Laser Refractive Center (Hamilton, Sanchez), Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, Los Angeles, California, USA. Electronic address: mojtaba_abrishami@yahoo.com.
Mojtaba
M
Abrishami
D057128:Aberrometry; D000328:Adult; D015350:Contrast Sensitivity / Q000502:physiology; D057108:Corneal Wavefront Aberration / Q000503:physiopathology*; D005260:Female; D019466:Glare; D006801:Humans; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D018903:Photorefractive Keratectomy / Q000379:methods*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult