Transcriptome-wide dynamics of RNA pseudouridylation.
Pseudouridylation is the most abundant internal post-transcriptional modification of stable RNAs, with fundamental roles in the biogenesis and function of spliceosomal small nuclear RNAs (snRNAs) and ribosomal RNAs (rRNAs). Recently, the first transcriptome-wide maps of RNA pseudouridylation were published, greatly expanding the catalogue of known pseudouridylated RNAs. These data have further implicated RNA pseudouridylation in the cellular stress response and, moreover, have established that mRNAs are also targets of pseudouridine synthases, potentially representing a novel mechanism for expanding the complexity of the cellular proteome.
Department of Plant and Microbial Biology, University of California, 565 Li Ka Shing Center #3370, Berkeley, California 94720-337, USA.
John
J
Karijolich
State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Synthetic and Functional Biomolecules Center and Peking-Tsinghua Center for Life Sciences, Peking University, 5 Summer Palace Road, Haidian District, Beijing 100871, China.
Chengqi
C
Yi
Department of Biochemistry and Biophysics, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 712 Rochester, New York 14642, USA.
Yi-Tao
YT
Yu
D000818:Animals; D006801:Humans; D011560:Pseudouridine / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000378:metabolism*; D012342:RNA, Small Nuclear / Q000378:metabolism*; D059467:Transcriptome / Q000502:physiology*
D012335:RNA, Ribosomal; D012342:RNA, Small Nuclear; D011560:Pseudouridine