Network Comparison of Inflammation in Colorectal Cancer and Alzheimer's Disease.
Recently, a large clinical study revealed an inverse correlation of individual risk of cancer versus Alzheimer's disease (AD). However, no explanation exists for this anticorrelation at the molecular level; however, inflammation is crucial to the pathogenesis of both diseases, necessitating a need to understand differing signaling usage during inflammatory responses distinct to both diseases. Using a subpathway analysis approach, we identified numerous well-known and previously unknown pathways enriched in datasets from both diseases. Here, we present the quantitative importance of the inflammatory response in the two disease pathologies and summarize signal transduction pathways common to both diseases that are affected by inflammation.
New Experimental Therapeutics Branch, National Cancer Center, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
Sungjin
S
Park
Supercomputing R&D Center, Korea Institute of Science and Technology Information (KISTI), Daejeon 305-806, Republic of Korea.
Seok Jong
SJ
Yu
Supercomputing R&D Center, Korea Institute of Science and Technology Information (KISTI), Daejeon 305-806, Republic of Korea.
Yongseong
Y
Cho
Bioscience Advising, Indianapolis, IN 46227, USA.
Curt
C
Balch
Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
Jinhyuk
J
Lee
New Experimental Therapeutics Branch, National Cancer Center, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
Yon Hui
YH
Kim
New Experimental Therapeutics Branch, National Cancer Center, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
Seungyoon
S
Nam
D000544:Alzheimer Disease / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism*; D003198:Computer Simulation; D016207:Cytokines / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000378:metabolism*; D008954:Models, Biological; D025941:Protein Interaction Mapping / Q000379:methods; D015398:Signal Transduction
D016207:Cytokines