Current status and patent prospective of animal models in diabetic research.
Diabetes mellitus is a heterogeneous complex metabolic disorder with multiple etiology which characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action or both. The widespread occurrence of diabetes throughout the world has increased dramatically over the past few years. For better understanding, appropriate animal models that closely mimic the changes in humans needed, as vital tool for understanding the etiology and pathogenesis of the disease at the cellular/molecular level and for preclinical testing of drugs. This review aims to describe the animal models of type-1 diabetes (T1Ds) and T2Ds to mimic the causes and progression of the disease in humans. And also we highlight patent applications published in the last few years related to animal models in diabetes as an important milestone for future therapies that are aim to treating diabetes with specific symptoms and complications.
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Radhey S
RS
Dhuria
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Gurpreet
G
Singh
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Anudeep
A
Kaur
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Ramandeep
R
Kaur
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Tanurajvir
T
Kaur
Alloxan-susceptible/Lt mouse; animal models; diabetes mellitus; dithizone; nonrodent models; patent