MAP Kinase Cascades in Antigen Receptor Signaling and Physiology.
Mitogen-activated protein kinases (MAPKs) play roles in a cell type and context-dependent manner to convert extracellular stimuli to a variety of cellular responses, thereby directing cells to proliferation, differentiation, survival, apoptosis, and migration. Studies of genetically engineered mice or chemical inhibitors specific to each MAPK signaling pathway revealed that MAPKs have various, but non-redundant physiologically important roles among different families. MAPK cascades are obviously integrated in the B cell receptor signaling pathways as critical components to drive B cell-mediated immunity.
Immune Regulation and Cancer, Max Delbrück Center for Molecular Medicine, Robert-Rössle Str 10, 13125, Berlin, Germany. tomoharu.yasuda@mdc-berlin.de.
Tomoharu
T
Yasuda
D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology* / Q000276:immunology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D020935:MAP Kinase Signaling System
D048049:Extracellular Signal-Regulated MAP Kinases