Design, characterization and in vitro evaluation of novel shell crosslinked poly(butylene adipate)-co-N-succinyl chitosan nanogels containing loteprednol etabonate: A new system for therapeutic effect enhancement via controlled drug delivery.
This study reports on the development of a novel mucoadhesive and biocompatible shell-crosslinked nanogel system based on poly(butylene adipate) (PBA) and N-succinyl chitosan (S-Cs) by coupling reaction with a new formulation method. For this purpose, two different molecular weights of dendrimerized PBA with amine terminated functional groups were synthesized separately and characterized well by FT-IR, (1)HNMR and GPC. The PBA nanoparticles containing loteprednol etabonate (LPE) prepared by O/W emulsion technique were reacted immediately with modified carboxylated chitosan via carbodiimide chemistry. TEM photographs of the nanoparticles and crosslinked nanoparticles displayed a spherical morphology closely corresponding to the results obtained by DLS. On The other hand, biodegradability, biocompatibility and bioadhesiveness of the prepared nanoparticles were also studied. It is concluded that the core-shell structured nanogels can be used as novel ocular drug delivery systems with appropriate loading capacity for slightly water soluble LPE as an anti-inflammatory drug.
Polymer Laboratory, Chemistry Department, School of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
Farzaneh Hashemi
FH
Nasr
Polymer Laboratory, Chemistry Department, School of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran. Electronic address: Khoee@khayam.ut.ac.ir.
Sepideh
S
Khoee
D000818:Animals; D002072:Butylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D015195:Drug Design; D019573:Epithelium, Corneal / Q000166:cytology / Q000187:drug effects; D005260:Female; D000069559:Loteprednol Etabonate / Q000737:chemistry*; D015394:Molecular Structure; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D002072:Butylene Glycols; D003432:Cross-Linking Reagents; C118639:N-succinyl-chitosan; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; C009204:butylene glycol adipic acid polyester; D011094:Polyethyleneimine; D048271:Chitosan; D000069559:Loteprednol Etabonate
Loteprednol etabonate; N-succinyl chitosan; Ocular therapy; Poly(butylene adipate); Shell-crosslinked nanogel