Lack of association between type 2 diabetes and major depression: epidemiologic and genetic evidence in a multiethnic population.
The positive association between depression and type 2 diabetes (T2D) has been controversial, and little is known about the molecular determinants linking these disorders. Here we investigated the association between T2D and depression at the clinical and genetic level in a multiethnic cohort. We studied 17,404 individuals from EpiDREAM (3209 depression cases and 14,195 controls) who were at risk for T2D and had both phenotypic and genotypic information available at baseline. The glycemic status was determined using the 2003 American Diabetes Association criteria and an oral glucose tolerance test. Major depressive episode during the previous 12 months was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnostic criteria. Twenty single-nucleotide polymorphisms (SNPs) previously associated with T2D were genotyped using the cardiovascular gene-centric 50-K SNP array and were analyzed separately and in combination using an unweighted genotype score (GS). Multivariate logistic regression models adjusted for age, sex, ethnicity and body mass index were performed. Newly diagnosed impaired fasting glucose (IFG)/impaired glucose tolerance (IGT), T2D and dysglycemia status were not associated with major depression (0.30 ⩽ P ⩽ 0.65). Twelve out of twenty SNPs and the GS were associated with IFG/IGT, T2D and/or dysglycemia status (6.0 × 10(-35) ⩽ P ⩽ 0.048). In contrast, the 20 SNPs and GS were not associated with depression (P ⩾ 0.09). Our cross-sectional data do not support an association between T2D and depression at the clinical and genetic level in a multiethnic population at risk for T2D.
1] Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada [2] Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada [3] Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada.
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Samaan
Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada.
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Garasia
1] Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada [2] Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada [3] Department of Medicine, McMaster University, Hamilton, ON, Canada.
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Gerstein
Department of Medicine, McGill University, Montreal, QC, Canada.
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Engert
Madras Diabetes Research Foundation, Chennai, India.
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Mohan
ECLA Academic Research Organization, Rosario, Argentina.
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Diaz
1] Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada [2] Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada [3] Department of Medicine, McMaster University, Hamilton, ON, Canada.
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Anand
1] Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada [2] Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada [3] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
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Meyre
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000235:genetics; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000235:genetics* / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics* / Q000523:psychology; D005006:Ethnicity / Q000523:psychology* / Q000706:statistics & numerical data*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
D001786:Blood Glucose