Taste Masking of Griseofulvin and Caffeine Anhydrous Using Kleptose Linecaps DE17 by Hot Melt Extrusion.
The objective of this project was to investigate the potential of Kleptose Linecaps DE17 (KLD) in masking the unpleasant/bitter taste of therapeutic agents by hot melt extrusion (HME). Griseofulvin (GRI) and caffeine anhydrous (CA) were used as a bitter active pharmaceutical ingredient (API) model drugs. Thermogravimetric studies confirmed the stability of GRI, CA, and KLD at the employed extrusion temperatures. The differential scanning calorimetry (DSC) studies revealed a characteristic melting endotherm of GRI at 218-220°C and CA at 230-232°C in the physical mixtures as well as in all extrudates over the period of study, indicating the crystalline nature of drug. HME of KLD was achieved only in the presence of plasticizer. Among the several plasticizers investigated, xylitol showed improved processability of KLD at 15% w/w concentration. Dissolution studies of HME extrudates using simulated salivary medium exhibited ∼threefold less release compared to physical mixture at the end of 5 min (the lesser drug release, better the taste masking efficiency). Furthermore, the results from the sensory evaluation of products in human panel demonstrated strong bitter taste in the case of physical mixture compared to the HME formulation, suggesting the potential of Kleptose Linecaps DE17 as taste masking polymer in melt extruded form.
Department of Pharmaceutics and Drug Delivery, University of Mississippi, University, Mississippi, 38677, USA.
Abhishek
A
Juluri
Roquette America Inc., 2211 Innovation Dr., Geneva, Illinois, 60134, USA. carmen.popescu@roquette.com.
Carmen
C
Popescu
Roquette America Inc., 2211 Innovation Dr., Geneva, Illinois, 60134, USA.
Leon
L
Zhou
Institute for Drug Delivery and Biomedical Research, Bangalore, India, 560086.
Reena N
RN
Murthy
Institute for Drug Delivery and Biomedical Research, Bangalore, India, 560086.|Visveswarapuram Institute of Pharmaceutical Sciences, Bangalore, India, 560086.
Vanaja K
VK
Gowda
Visveswarapuram Institute of Pharmaceutical Sciences, Bangalore, India, 560086.
P
P
Chetan Kumar
Department of Pharmaceutics and Drug Delivery, University of Mississippi, University, Mississippi, 38677, USA.
Manjeet B
MB
Pimparade
Department of Pharmaceutics and Drug Delivery, University of Mississippi, University, Mississippi, 38677, USA.
Michael A
MA
Repka
Department of Pharmaceutics and Drug Delivery, University of Mississippi, University, Mississippi, 38677, USA.
S Narasimha
SN
Murthy
D000293:Adolescent; D000328:Adult; D002110:Caffeine / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry; D005260:Female; D005615:Freezing; D006118:Griseofulvin / Q000737:chemistry*; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D010968:Plasticizers / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013649:Taste; D055697:Taste Perception / Q000187:drug effects*; D013678:Technology, Pharmaceutical / Q000379:methods*; D014993:Xylitol / Q000737:chemistry; D055815:Young Adult
D004337:Drug Carriers; D010968:Plasticizers; D011108:Polymers; D006118:Griseofulvin; D002110:Caffeine; D014993:Xylitol
Kleptose linecaps DE17; caffeine anhydrous; griseofulvin; hot melt extrusion; human panel studies; taste masking