Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Bo
B
Cui
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Lei
L
Feng
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China; College of Natural Resources and Environment, College of Plant Science, Jilin University, Changchun, China.
Zhenzhong
Z
Pan
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Manli
M
Yu
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Zhanghua
Z
Zeng
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Changjiao
C
Sun
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Xiang
X
Zhao
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Yan
Y
Wang
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Haixin
H
Cui
D016573:Agrochemicals / Q000737:chemistry* / Q000494:pharmacology*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D018556:Crops, Agricultural / Q000378:metabolism / Q000469:parasitology; D004355:Drug Stability; D004463:Ecology; D004777:Environment; D036103:Nanotechnology / Q000379:methods; D009570:Nitriles / Q000737:chemistry* / Q000494:pharmacology*; D009930:Organic Chemicals / Q000737:chemistry; D010573:Pesticide Residues / Q000737:chemistry; D010575:Pesticides / Q000737:chemistry* / Q000494:pharmacology*; D010944:Plants / Q000378:metabolism / Q000469:parasitology; D011722:Pyrethrins / Q000737:chemistry* / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry
D016573:Agrochemicals; D009570:Nitriles; D009930:Organic Chemicals; D010573:Pesticide Residues; D010575:Pesticides; D011722:Pyrethrins; D012997:Solvents; C037304:cyhalothrin