Ethnic and geographic variations in HPV prevalence and genotype distribution in north-western Yunnan, China.
The prevalence and genotype distribution of human papillomavirus (HPV) vary throughout the world. To assess the prevalence and genotype distribution of HPV among three ethnic groups in two geographic locations in north-western Yunnan, we recruited 522 women in Shangri-le (n = 255) and Lijiang (n = 267). PCR amplification of HPV DNA was performed on cervical cells from these women using two consensus primer systems (MY09/11 and GP5/6). Amplified-HPV DNA was genotyped using the HPV GenoArray test. Geographically, the HPV prevalence was significantly higher (P = 0.002) among Shangri-le women than among Lijiang women. Infections with high-risk (HR)-HPV and with multiple HPV genotypes were also significantly more common (P = 0.001) among women in Shangri-le than women in Lijiang. Additionally, the prevalence of overall, HR-HPV, and single genotype HPV infections was significantly higher (P = 0.001) among Tibetan women than among Naxi and Han women. HPV-16 and HPV-33 were significantly more frequent in Shangri-le women compared with Lijiang (P = 0.006) women. In addition, HPV-16 (9.81%) and HPV-33 (5.88%) were significantly more prevalent in Tibetan women than in Naxi and Han women. Here, for the first time, we highlight the significant variation in the prevalence and genotype distribution of HPV in various populations in the north-western region of Yunnan Province.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.|Research Center for Molecular Medicine, Kunming, 650500, China.
Zulqarnain
Z
Baloch
First Hospital, Yunnan Province, Kunming, 650034, China.
Tao
T
Yuan
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.|Research Center for Molecular Medicine, Kunming, 650500, China.
Binghui
B
Wang
Second Affiliated Hospital, Kunming Medical University, Kunming, 650101, China.
Wenlin
W
Tai
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.|Research Center for Molecular Medicine, Kunming, 650500, China.
Yue
Y
Feng
First Hospital, Yunnan Province, Kunming, 650034, China.
Yanqing
Y
Liu
First Hospital, Yunnan Province, Kunming, 650034, China.
Xiao
X
Li
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.|Research Center for Molecular Medicine, Kunming, 650500, China.
Yue
Y
Feng
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.|Research Center for Molecular Medicine, Kunming, 650500, China.
Li
L
Liu
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.|Research Center for Molecular Medicine, Kunming, 650500, China.
A-mei
AM
Zhang
First Hospital, Yunnan Province, Kunming, 650034, China.
Xiaomei
X
Wu
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.|Research Center for Molecular Medicine, Kunming, 650500, China.
Xueshan
X
Xia
D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000821:virology; D002681:China / Q000453:epidemiology; D017931:DNA Primers; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000208:ethnology* / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000821:virology
D017931:DNA Primers; D004279:DNA, Viral
HPV prevalence; Lijiang; Shangri-le; ethnic; north-western Yunnan; regional