Dietary glycemia as a determinant of health and longevity.
The role of diet in extending lifespan and healthspan has been the subject of much research and debate. Our recent epidemiological and in vivo data suggest that carbohydrate quality can be a major determinant in prolonging eye health. Additionally, excessive carbohydrate intake can contribute to the exacerbation of many different diseases. The metabolic diversity of the tissues that are affected by excessive carbohydrate intake suggests that dietary carbohydrate quality may affect cellular homeostasis.
Laboratory for Nutrition and Vision Research, USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Elizabeth A
EA
Whitcomb
Laboratory for Nutrition and Vision Research, USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Chung-Jung
CJ
Chiu
Laboratory for Nutrition and Vision Research, USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. Electronic address: allen.taylor@tufts.edu.
Allen
A
Taylor
D000818:Animals; D004032:Diet / Q000009:adverse effects*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D038321:Glycemic Index / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008136:Longevity / Q000502:physiology*
D004040:Dietary Carbohydrates
Autophagy; Eye disease; Glycation; Glycemic index; Proteasome; Ubiquitin