Stereoselective Synthesis of 4-Substituted Cyclic Sulfamidate-5-Phosphonates by Using Rh-Catalyzed, Asymmetric Transfer Hydrogenation with Accompanying Dynamic Kinetic Resolution.
Dynamic kinetic resolution driven, asymmetric transfer hydrogenation of 4-substituted cyclic sulfamidate imine-5-phosphonates produces the corresponding cyclic sulfamidate-5-phosphonates. The process employs a HCO2H/Et3N mixture as the hydrogen source and the chiral Rh catalysts, (R,R)- or (S,S)-Cp*RhCl(TsDPEN), and it takes place at room temperature within 1 h with high yields and high levels of stereoselectivity.
Korea Chemical Bank, Korea Research Institute of Chemical Technology , P.O. Box 107, Yuseong, Daejeon 305-600, Korea.|Department of Medicinal Chemistry and Pharmacology, University of Science and Technology , 113 Gwahango, Yuseong, Daejeon 305-333, Korea.
Yeon Ji
YJ
Seo
Korea Chemical Bank, Korea Research Institute of Chemical Technology , P.O. Box 107, Yuseong, Daejeon 305-600, Korea.
Jin-ah
JA
Kim
Korea Chemical Bank, Korea Research Institute of Chemical Technology , P.O. Box 107, Yuseong, Daejeon 305-600, Korea.|Department of Medicinal Chemistry and Pharmacology, University of Science and Technology , 113 Gwahango, Yuseong, Daejeon 305-333, Korea.
Hyeon-Kyu
HK
Lee