Four new fawcettimine-related alkaloids from Phlegmariurus squarrosus.
Four new fawcettimine-related alkaloids (1-4), together with 17 known ones, were isolated from club moss Phlegmariurus squarrosus. Notably, compound 1 was the derivative of lycoflexine with an unprecedented additional methyl group at C-17. Their structures were determined by extensive spectroscopic analysis, including 1D and 2D NMR, and HR-MS, as well as by comparison with the literature data. All new compounds were tested for their β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) and acetylcholinesterase (AChE) inhibitory activities.
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.|b University of the Chinese Academy of Sciences , Beijing 100049 , China.
Yu-Chen
YC
Liu
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.|b University of the Chinese Academy of Sciences , Beijing 100049 , China.
Min
M
Fan
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.|b University of the Chinese Academy of Sciences , Beijing 100049 , China.
Wei-Wei
WW
Jiang
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.|b University of the Chinese Academy of Sciences , Beijing 100049 , China.
Fei
F
Liu
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
Xing-De
XD
Wu
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
Juan
J
He
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
Xiao
X
Cheng
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
Li-Yan
LY
Peng
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
Jia
J
Su
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
Zhi-Jun
ZJ
Zhang
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
Qin-Shi
QS
Zhao
D000470:Alkaloids / Q000737:chemistry*; D053829:Amyloid Precursor Protein Secretases / Q000187:drug effects; D016282:Aspartic Acid Endopeptidases / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029542:Lycopodiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; C524731:fawcettimine; C555161:lycoflexine; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human
AChE inhibitory activity; BACE1 inhibitory activity; Phlegmariurus squarrosus; fawcettimine-related alkaloids