Synthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C-H Borylation.
The preparation of fluoroalkoxy arylboronic esters by iridium-catalyzed aromatic C-H borylation is described. The fluoroalkoxy groups employed include trifluoromethoxy, difluoromethoxy, 1,1,2,2-tetrafluoroethoxy, and 2,2-difluoro-1,3-benzodioxole. The borylation reactions were carried out neat without the use of a glovebox or Schlenk line. The regioselectivities available through the iridium-catalyzed C-H borylation are complementary to those obtained by the electrophilic aromatic substitution reactions of fluoroalkoxy arenes. Fluoroalkoxy arylboronic esters can serve as versatile building blocks.
Department of Chemistry, Syed Babar Ali School of Science & Engineering, Lahore University of Management Sciences , Lahore 54792, Pakistan.|Institute of Chemistry, University of the Punjab , Lahore 54590, Pakistan.
Farhat
F
Batool
Department of Chemistry, Syed Babar Ali School of Science & Engineering, Lahore University of Management Sciences , Lahore 54792, Pakistan.
Shehla
S
Parveen
Imaging and Characterization Core Lab, King Abdullah University of Science and Technology , Thuwal 23955-6900, Kingdom of Saudi Arabia.
Abdul-Hamid
AH
Emwas
Imaging and Characterization Core Lab, King Abdullah University of Science and Technology , Thuwal 23955-6900, Kingdom of Saudi Arabia.
Salim
S
Sioud
Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology , Thuwal 23955-6900, Kingdom of Saudi Arabia.
Xin
X
Gao
Institute of Chemistry, University of the Punjab , Lahore 54590, Pakistan.
Munawar A
MA
Munawar
Department of Chemistry, Syed Babar Ali School of Science & Engineering, Lahore University of Management Sciences , Lahore 54792, Pakistan.
Ghayoor A
GA
Chotana