[DEMOCOPHES SPAIN AND ITS CONTRIBUTION TO THE HARMONIZATION OF EUROPEAN HUMAN BIOMONITORING].
Objetive: contributing to demonstrate of the feasibility of a coordinated action on human biomonitoring in Europe (DEMOCOPHES project) and demonstrate the utility of HBM studies to assess the influence of diet and lifestyle in environmental exposures.


METHODS
the EU protocol was adapted to the national requirements. The quality controls defined herein were followed and special care was taken to ensure the comparability of the results among participating countries.


RESULTS
the protocol adaptation did not shown significant difficulties. Only minor changes were applied, so the original design of the study was respected. 134 mother- child pairs were selected in one school in Añover de Tajo (Toledo) and three schools in Madrid. All volunteers donated a urine and hair sample and complete the epidemiological questionnaire. Significant differences were found in the participation rates between the sampling locations.


CONCLUSIONS
standardization of all steps in a human biomonitoring study is essential for its harmonized development in Europe. The results has contributed to obtain for the first time comparable data about environmental exposure in the general population within 17 EU countries showing the differences associated with diet and lifestyles. The experiences and materials developed in the fieldwork could be applied to the design and implementation of HBM studies in the future.
Área de Toxicología Ambiental. Centro Nacional de Sanidad Ambiental. Instituto de Salud Carlos III. Madrid.. m.esteban@isciii.es.
Marta
M
Esteban López
Instituto de Investigación de Enfermedades Raras. Instituto de Salud Carlos III, Madrid, España.. castano@isciii.es.
Estrella
E
López Martín
Área de Toxicología Ambiental. Centro Nacional de Sanidad Ambiental. Instituto de Salud Carlos III. Madrid.. castano@isciii.es.
Carolina
C
Rodríguez García
Instituto de Investigación de Enfermedades Raras. Instituto de Salud Carlos III, Madrid, España.. castano@isciii.es.
Manuel
M
Posada De la Paz
Área de Toxicología Ambiental. Centro Nacional de Sanidad Ambiental. Instituto de Salud Carlos III. Madrid.. castano@isciii.es.
Argelia
A
Castaño Calvo
D004032:Diet; D004781:Environmental Exposure; D004784:Environmental Monitoring; D006197:Hair / Q000737:chemistry; D006801:Humans; D008019:Life Style; D062486:Public Health Surveillance; D011786:Quality Control; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires; D016482:Urinalysis