Acute severe organophosphate poisoning in a child who was successfully treated with therapeutic plasma exchange, high-volume hemodiafiltration, and lipid infusion.
Acute severe organophosphate poisoning is a serious complication seen in developing and agricultural countries. Pralidoxime and high dose atropine are the standard treatments. There is no consensus about acute severe organophosphate poisonings that are unresponsive to pralidoxime, atropine, and supportive therapies. We report a case of acute severe organophosphate poisoning that was unresponsive to standard treatments and successfully treated with high-volume continuous venovenous hemodiafiltration and therapeutic plasma exchange combined with lipid infusion. J. Clin. Apheresis 31:467-469, 2016. © 2015 Wiley Periodicals, Inc.
Pediatric İntensive Care Unit, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey. drosmanyesilbas@gmail.com.
Osman
O
Yesilbas
Pediatric İntensive Care Unit, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Hasan S
HS
Kihtir
Departmant of Pediatrics, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Mohammad
M
Altiti
Pediatric İntensive Care Unit, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Mey Talip
MT
Petmezci
Pediatric İntensive Care Unit, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Seda
S
Balkaya
Departmant of Pediatrics, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Burcu
B
Bursal Duramaz
Departmant of Pediatric Metabolism Diseases, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Melike
M
Ersoy
Pediatric İntensive Care Unit, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Esra
E
Sevketoglu
D001285:Atropine; D002648:Child; D017583:Hemodiafiltration; D006801:Humans; D007262:Infusions, Intravenous; D008055:Lipids / Q000008:administration & dosage*; D062025:Organophosphate Poisoning / Q000628:therapy*; D010951:Plasma Exchange; D011220:Pralidoxime Compounds; D016879:Salvage Therapy / Q000379:methods*
D008055:Lipids; D011220:Pralidoxime Compounds; D001285:Atropine; C028797:pralidoxime
Acute severe organophosphate poisoning; hemodiafiltration; lipid infusion; therapeutic plasma exchange