Thrombotic thrombocytopenic purpura in a postoperative patient taking cephalexin responding to plasmapheresis: A case report and review of cephalosporin-induced TTP.
The clinical presentation of thrombotic thrombocytopenic purpura (TTP) is often atypical delaying diagnosis and treatment. A number of drugs have been implicated in the development of TTP, including cyclosporine, tacrolimus, clopidogrel, and quinine. To our knowledge, only three cases of cephalosporin-induced TTP have been described, with two of these cases occurring with these use of cephalexin. We herein describe a case of TTP occurring in a postoperative patient taking cephalexin, requiring plasmapheresis. Following plasmapheresis, the patient's mental status and platelet count significantly improved. J. Clin. Apheresis 31:473-475, 2016. © 2015 Wiley Periodicals, Inc.
Department of Internal Medicine, MacNeal Hospital, Berwyn, Illinois.
Ritu
R
Patel
Department of Internal Medicine, MacNeal Hospital, Berwyn, Illinois. kamber@uci.edu.|Department of Dermatology, University of California Irvine Health Center, Irvine, California. kamber@uci.edu.
Kyle T
KT
Amber
D002506:Cephalexin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010956:Plasmapheresis; D010976:Platelet Count; D011183:Postoperative Complications; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000628:therapy*
D002506:Cephalexin
TTP; cephalosporin; plasmapheresis