The locoregional recurrence post-mastectomy for ductal carcinoma in situ: Incidence and risk factors.
BACKGROUND
The objective of this retrospective study was to determine the incidence of recurrence of breast cancer after mastectomy for ductal carcinoma in situ (DCIS) in our institution, and to evaluate the associated risk factors while comparing them to those proposed in the literature.


METHODS
The files of 218 patients who had undergone mastectomy for pure DCIS or DCIS with micro-invasion at Centre Eugène Marquis between January 2003 and November 2013 were compared for: age at diagnosis, type of mastectomy and immediate reconstruction, tumor characteristics, and the evaluation of the sentinel axillary lymph node. The mean follow-up period was 30.5 months.


RESULTS
In a mean period of 39.13 months, 8 patients (3.67%) developed a recurrence post-mastectomy, 2 of whom with distant metastasis. Two others developed distant metastases subsequently during treatment. All 4 died due to progression of metastases, while the other 4 are alive and disease-free after treatment. The only risk factor was young age at initial diagnosis (<40 years). None of the other factors described in the literature, such as high grade or diffuse disease, comedo-necrosis, positive margins or micro-invasion were statistically significant.


CONCLUSIONS
The recurrence of breast cancer after mastectomy for DCIS is rare, however, it carries a high mortality rate for those who do relapse. Patients who have high risk factors such as young age at diagnosis and high risk tumor factors should be followed closely for signs of recurrence and/or metastasis.
Surgical Oncology Department, Eugène Marquis Comprehensive Cancer Center, Rue de la Bataille Flandres Dunkerque, F-35 000, Rennes, France. Electronic address: s.bannani@hotmail.com.
Sahar
S
Bannani
Surgical Oncology Department, Eugène Marquis Comprehensive Cancer Center, Rue de la Bataille Flandres Dunkerque, F-35 000, Rennes, France; Department of Gynecology, Anne de Bretagne University Hospital, 16 Boulevard de Bulgarie, BP 90 347, F-35 203, Rennes, Cedex 2, France. Electronic address: sophie_rouquette@yahoo.fr.
Sophie
S
Rouquette
Surgical Oncology Department, Eugène Marquis Comprehensive Cancer Center, Rue de la Bataille Flandres Dunkerque, F-35 000, Rennes, France. Electronic address: c.bendavid@rennes.unicancer.fr.
Cecile
C
Bendavid-Athias
Surgical Oncology Department, Eugène Marquis Comprehensive Cancer Center, Rue de la Bataille Flandres Dunkerque, F-35 000, Rennes, France. Electronic address: ptas@atalante-pathologie.fr.
Patrick
P
Tas
Surgical Oncology Department, Eugène Marquis Comprehensive Cancer Center, Rue de la Bataille Flandres Dunkerque, F-35 000, Rennes, France; Department of Gynecology, Anne de Bretagne University Hospital, 16 Boulevard de Bulgarie, BP 90 347, F-35 203, Rennes, Cedex 2, France. Electronic address: jean.leveque@chu-rennes.fr.
Jean
J
Levêque
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000556:secondary / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D035441:Thoracic Wall
Breast cancer recurrence; Chest wall recurrence; Ductal carcinoma in situ; Intraductal carcinoma; Post-mastectomy