Discovery of new feline paramyxoviruses in domestic cats with chronic kidney disease.
Paramyxoviruses constitute a large family of enveloped RNA viruses including important pathogens in veterinary and human medicine. Recently, feline paramyxoviruses, genus morbillivirus, were detected in cats from Hong Kong and Japan. Here we describe the discovery of several new feline paramyxoviruses. Infections with these diverse viruses were detected in urine samples from cats suffering from chronic kidney disease (CKD). No viral RNA was found in cats without clinical signs of uropathy highlighting an association between feline paramyxovirus (FPaV) infections and CKD. Phylogenetic analyses of the detected viruses showed that they represent at least two different species, one of them representing the feline morbilliviruses detected previously in Hong Kong and Japan. In addition, a new FPaV was detected sharing only 73 % homology on the nucleotide level of the viral L-gene to currently known paramyxoviral species.
Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, 04103, Leipzig, Germany.
Michael
M
Sieg
Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, 04103, Leipzig, Germany.
Kristin
K
Heenemann
Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, 04103, Leipzig, Germany.
Antje
A
Rückner
University Clinic for Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Iwan
I
Burgener
Department of Small Animal Medicine, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
Gerhard
G
Oechtering
Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, 04103, Leipzig, Germany. thomas.vahlenkamp@uni-leipzig.de.
Thomas W
TW
Vahlenkamp
D000818:Animals; D002371:Cat Diseases / Q000473:pathology* / Q000821:virology*; D002415:Cats; D016000:Cluster Analysis; D008969:Molecular Sequence Data; D018184:Paramyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D018098:Paramyxovirinae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D051436:Renal Insufficiency, Chronic / Q000662:veterinary* / Q000821:virology; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014556:Urine / Q000821:virology
D012367:RNA, Viral
Cat; FLUTD; Paramyxoviruses; Urine