Recent advances in biosensing using magnetic glyconanoparticles.
In this critical review we discuss the most recent advances in the field of biosensing applications of magnetic glyconanoparticles. We first give an overview of the main synthetic routes to obtain magnetic-nanoparticle-carbohydrate conjugates and then we highlight their most promising applications for magnetic relaxation switching sensing, cell and pathogen detection, cell targeting and magnetic resonance imaging. We end with a critical perspective of the field, identifying the main challenges to be overcome, but also the areas where the most promising developments are likely to happen in the coming decades.
Instituto de Nanociencia de Aragon, Universidad de Zaragoza, C/Mariano Esquillor s/n, 50018, Zaragoza, Spain.|Fundación ARAID, C/María de Luna 11, Edificio CEEI Aragón, 50018, Zaragoza, Spain.
Raluca M
RM
Fratila
Instituto de Nanociencia de Aragon, Universidad de Zaragoza, C/Mariano Esquillor s/n, 50018, Zaragoza, Spain.
María
M
Moros
ICMA, CSIC/Universidad de Zaragoza, C/Pedro Cerbuna 12, 50009, Zaragoza, Spain. jmfuente@unizar.es.|Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Research Institute of Translation Medicine, Shanghai Jiao Tong University, Dongchuan Road 800, 200240, Shanghai, China. jmfuente@unizar.es.
Jesús M
JM
de la Fuente
D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry*; D002469:Cell Separation / Q000379:methods; D058948:Cell Tracking / Q000379:methods; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics / Q000379:methods; D059346:Magnets / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*
D002241:Carbohydrates
Biosensing; Carbohydrates; Magnetic glyconanoparticles; Magnetic relaxation switching; Nanotechnology