Dynamics of P53 in response to DNA damage: Mathematical modeling and perspective.
Cells are constantly challenged by intrinsic and extrinsic signals. DNA damage denotes a serious threat to cellular survival due to its extensive destroy to genomic integrity. Appropriate dynamic responses to changing signals are essential for homeostasis. The tumor suppressor p53 can respond to DNA damage and elicit diverse dynamical patterns. How signals and information are encoded and decoded in p53 network under DNA damaging stimuli are not fully understood. From theoretical perspective, we focus on the dynamical patterns of p53 and how such complex dynamics relate to cell fate leading to a better knowledge about its regulation and function.
School of Life Sciences, AnQing Normal University, Anqing, 246011, Anhui, PR China. Electronic address: confucian007@126.com.
Tingzhe
T
Sun
Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, Guangdong, PR China. Electronic address: cuij5@mail.sysu.edu.cn.
Jun
J
Cui
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D019070:Cell Lineage; D049109:Cell Proliferation; D002470:Cell Survival; D016922:Cellular Senescence; D004249:DNA Damage; D025461:Feedback, Physiological; D023281:Genomics; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
Bimodality; Cell fate decision; Mathematical modeling; Pulse; p53