Tumor Heterogeneity: Focus on the Leaves, the Trees, or the Forest?
Molecular studies of intra-tumor heterogeneity (ITH) are revealing a large amount of DNA-based variation in many individual tumors. In a recent publication by Yates and colleagues, the ITH of breast tumors was examined and shown to have important implications for the development of resistant disease, metastasis, and clinical sequencing efforts.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Joel S
JS
Parker
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: cperou@med.unc.edu.
Charles M
CM
Perou
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D056915:DNA Copy Number Variations; D005260:Female; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D018365:Neoplasm, Residual / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
D000970:Antineoplastic Agents