Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma.
Prolonged clotting times were observed in a patient with spontaneous hemorrhage. Analysis showed severe factor X deficiency due to clearance by a noninhibitory antibody. Lymphadenopathy identified on imaging led to diagnosis of marginal B-cell lymphoma. Treatment of lymphoma with rituximab and chlorambucil resulted in complete disappearance of the bleeding disorder.
LabWest/ Haga Teaching Hospital The Hague, The Netherlands.
Annemarie
A
Meenhuis
Department of Haematology, Haga Teaching Hospital The Hague, The Netherlands.
Rianne
R
van Vliet
LabWest/ Haga Teaching Hospital The Hague, The Netherlands.
Francisca
F
Hudig
Department of Haematology, Haga Teaching Hospital The Hague, The Netherlands.
Paula F
PF
Ypma
Department of Haematology, Haga Teaching Hospital The Hague, The Netherlands.
Martin R
MR
Schipperus
Department of Immunopathology and Blood Coagulation, Sanquin Diagnostic Services Amsterdam, The Netherlands.
Martine J
MJ
Hollestelle
acquired coagulation disorders; clotting factor related research; non-Hodgkin lymphoma