[CORONARY ARTERY DISEASE AND HEART FAILURE: A GENOTYPE-BASED THERAPEUTIC APPROACH].
Phenotypic approach of the treatment of coronary artery disease and heart failure used in prospective randomized trials has contributed to significantly improve patieni prognosis. However, gene polymorphisms have been shown to be able to alter treatment efficacy with anti-platelets, beta-blockers or ACE-inhibitors in these settings. As suggested by several studies, therapeutic approaches based on genotype should contribute to personalize treatments with better efficacy and safety.
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Lancellotti
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Ancion
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000235:genetics; D005838:Genotype; D006333:Heart Failure / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D057285:Precision Medicine / Q000379:methods*
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D010975:Platelet Aggregation Inhibitors