[Relationship between perioperative blood transfusion and post-operative hospital infection in patients with closed traumatic brain injury].
OBJECTIVE
To explore the relationship between allogeneic transfusion and hospital infections in patients with closed traumatic brain injury in the perioperative period.


METHODS
The clinical data of 181 patients with open brain surgery suffering closed brain injury in Changsha Central Hospital from February, 2012 to December, 2013 were retrospectively collected. The patients were divided into a mild and moderate brain injury group (n=83) and a severe brain injury group (n=98) according to evaluation system of Glasgow coma scale (GCS). They were also divided into a autologous transfusion plus mild and moderate brain injury group (n=14), a autologous transfusion plus severe brain injury group (n=10); an allogeneic transfusion plus mild and moderate brain injury group (n=31), an allogeneic transfustion plus severe brain injury group (n=70); a non-transfusion plus mild and moderate brain injury group (n=38) and a non-transfusion plus severe brain injury group (n=18) according to the transfusion styles. The hospital infection of all the patients was examined.


RESULTS
The rate of hospital infection was significantly higher in the severe brain injury group than that in the mild and moderate brain injury group (P<0.05). The rate of post-operative hospital infection in the allogeneic transfusion plus severe brain injury group was also significantly higher than that in the autologous transfusion plus severe brain injury group (P<0.05). Similarly, the rate of post-operative hospital infection in the allogeneic transfusion plus mild and moderate brain injury group is higher than that in the non-transfusion plus mild and moderate brain injury group (P<0.05).


CONCLUSIONS
The allogeneic transfusion at perioperative period may be one of the risk factors for post-operative hospital infection in the closed brain injury patients. The more severe the injury is, the higher risk the hospital infection will be.
Department of Blood Transfusion, Changsha Central Hospital, Changsha 410004, China.
Jing
J
Xu
Hospital Infection Control Office, Changsha Central Hospital, Changsha 410004, China.
Xiaohong
X
Yao
Hospital Infection Control Office, Changsha Central Hospital, Changsha 410004, China.
Hebin
H
Xie
Department of Pharmacy, Changsha Central Hospital, Changsha 410004, China.
Lichen
L
Gao
D001803:Blood Transfusion; D001930:Brain Injuries / Q000601:surgery*; D003428:Cross Infection / Q000453:epidemiology*; D015600:Glasgow Coma Scale; D006801:Humans; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors