Changes in Metabolic Hormones in Malaysian Young Adults following Helicobacter pylori Eradication.
BACKGROUND
More than half of the world's adults carry Helicobacter pylori. The eradication of H. pylori may affect the regulation of human metabolic hormones. The aim of this study was to evaluate the effect of H. pylori eradication on meal-associated changes in appetite-controlled insulinotropic and digestive hormones, and to assess post-eradication changes in body mass index as part of a currently on-going multicentre ESSAY (Eradication Study in Stable Adults/Youths) study.


METHODS
We enrolled 29 H. pylori-positive young adult (18-30 year-old) volunteer subjects to evaluate the effect of H. pylori eradication on meal-associated changes on eight gastrointestinal hormones, using a multiplex bead assay. Changes in body mass index and anthropometric measurements were recorded, pre- and post-eradication therapy.


RESULTS
Pre-prandial active amylin, total peptide YY (PYY) and pancreatic polypeptide (PP) levels were significantly elevated 12 months post-eradication compared with baseline (n = 18; Wilcoxon's signed rank test, p<0.05). Four of the post-prandial gut metabolic hormones levels (GLP-1, total PYY, active amylin, PP) were significantly higher 12 months post-eradication compared to baseline (n = 18; p<0.05). Following H. pylori eradication, the BMI and anthropometric values did not significantly change.


CONCLUSIONS
Our study indicates that H. pylori eradication was associated with long-term disturbance in three hormones (active amylin, PP and total PYY) both pre- and post-prandially and one hormone (GLP-1) post-prandially. Longer post-eradication monitoring is needed to investigate the long-term impact of the observed hormonal changes on metabolic homeostasis.
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Theresa Wan-Chen
TW
Yap
Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Alex Hwong-Ruey
AH
Leow
Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Ahmad Najib
AN
Azmi
New York University Cancer Institute, New York University School of Medicine, New York, New York, United States of America; Department of Medicine, New York University School of Medicine, New York, New York, United States of America.
Fritz
F
Francois
Department of Medicine, New York University School of Medicine, New York, New York, United States of America; Department of Microbiology, New York University School of Medicine, New York, New York, United States of America.
Guillermo I
GI
Perez-Perez
Department of Medicine, New York University School of Medicine, New York, New York, United States of America; Department of Microbiology, New York University School of Medicine, New York, New York, United States of America.
Martin J
MJ
Blaser
BP Healthcare, 30250 Ipoh, Perak, Malaysia.
Bee-Hoon
BH
Poh
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Mun-Fai
MF
Loke
Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Khean-Lee
KL
Goh
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Jamuna
J
Vadivelu
D000328:Adult; D001066:Appetite / Q000502:physiology; D015992:Body Mass Index; D004435:Eating / Q000502:physiology; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D016481:Helicobacter Infections / Q000150:complications* / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D058228:Islet Amyloid Polypeptide / Q000378:metabolism; D008296:Malaysia; D008297:Male; D010191:Pancreatic Polypeptide / Q000378:metabolism; D019894:Peptide YY / Q000378:metabolism; D055815:Young Adult
D005768:Gastrointestinal Hormones; D058228:Islet Amyloid Polypeptide; D019894:Peptide YY; D010191:Pancreatic Polypeptide