Malaria-Induced B Cell Genomic Instability.
Nussenzweig and colleagues evaluate genomic instability and germinal center derived lymphomagenesis in mice infected with Plasmodium to recreate some of the hallmark characteristics of Burkitt lymphoma, a form of cancer more common in parts of Africa where malaria is endemic.
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, NY 10032, USA.
Gerson
G
Rothschild
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, NY 10032, USA.
A Nikolai
AN
von Krusenstiern
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, NY 10032, USA. Electronic address: ub2121@cumc.columbia.edu.
Uttiya
U
Basu
D000818:Animals; D003564:Cytidine Deaminase / Q000378:metabolism*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000201:enzymology* / Q000235:genetics*; D014178:Translocation, Genetic
D003564:Cytidine Deaminase