An Outbreak of Burkholderia cepacia Bacteremia in a Neonatal Intensive Care Unit.
OBJECTIVE
To identify the source of infection, to study the clinical profile and outcomes of neonates with Burkholderia septicemia and to determine the antimicrobial susceptibility patterns of the isolates.


METHODS
The authors describe a 3 mo outbreak of nosocomial Burkholderia cepacia bacteremia involving 12 neonates. During the outbreak, ventilator humidifier water, intravenous solutions and other possible sources were taken from the concerned neonatal intensive care units (NICUs); cultured and isolates identified by standard microbiological techniques and VITEK system. Clinical details of affected babies were also obtained to ascertain the clinical significance of the isolates.


RESULTS
All neonates had clinical and biochemical evidence of sepsis and the source could be tracked to intravenous solutions of 5% dextrose, normal saline (opened bottles) and continuous positive airway pressure humidifier water. Strain relatedness of the environmental isolates with the clinical isolates is likely as antibiotic susceptibility patterns were similar.


CONCLUSIONS
The investigations revealed the source of the nosocomial outbreak which is crucial for initiating appropriate control measures.
Department of Microbiology, Kasturba Medical College, Manipal University, Mangalore, India.
Liz Mary
LM
Paul
Department of Microbiology, Kasturba Medical College, Manipal University, Mangalore, India. ashwini.hegde@manipal.edu.
Ashwini
http://orcid.org/0000-0002-2872-0822
A
Hegde
Department of Pediatrics, Kasturba Medical College, Manipal University, Mangalore, India.
Tanvi
T
Pai
Department of Pediatrics, Kasturba Medical College, Manipal University, Mangalore, India.
Subodh
S
Shetty
Department of Microbiology, Kasturba Medical College, Manipal University, Mangalore, India.
Shrikala
S
Baliga
Department of Microbiology, Kasturba Medical College, Manipal University, Mangalore, India.
Suchitra
S
Shenoy
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D019121:Burkholderia Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D016956:Burkholderia cepacia / Q000302:isolation & purification*; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents
Bacteremia; Burkholderia; Neonate; Outbreak