Drug carrier interaction with blood: a critical aspect for high-efficient vascular-targeted drug delivery systems.
Vascular wall endothelial cells control several physiological processes and are implicated in many diseases, making them an attractive candidate for drug targeting. Vascular-targeted drug carriers (VTCs) offer potential for reduced side effects and improved therapeutic efficacy, however, only limited therapeutic success has been achieved to date. This is perhaps due to complex interactions of VTCs with blood components, which dictate VTC transport and adhesion to endothelial cells. This review focuses on VTC interaction with blood as well as novel 'bio-inspired' designs to mimic and exploit features of blood in VTC development. Advanced approaches for enhancing VTCs are discussed along with applications in regenerative medicine, an area of massive potential growth and expansion of VTC utility in the near future.
Department of Chemical Engineering, University of Michigan, Ann Arbor MI 48109, USA.
Daniel J
DJ
Sobczynski
Department of Chemical Engineering, University of Michigan, Ann Arbor MI 48109, USA.
Margaret B
MB
Fish
Department of Chemical Engineering, University of Michigan, Ann Arbor MI 48109, USA.
Catherine A
CA
Fromen
Department of Chemical Engineering, University of Michigan, Ann Arbor MI 48109, USA.
Mariana
M
Carasco-Teja
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Rhima M
RM
Coleman
Department of Chemical Engineering, University of Michigan, Ann Arbor MI 48109, USA.|Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Omolola
O
Eniola-Adefeso
D001769:Blood / Q000187:drug effects*; D001808:Blood Vessels / Q000187:drug effects*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D014652:Vascular Diseases / Q000188:drug therapy
D004337:Drug Carriers