Functionalised particles using dry powder coating in pharmaceutical drug delivery: promises and challenges.
BACKGROUND
Production of functionalised particles using dry powder coating is a one-step, environmentally friendly process that paves the way for the development of particles with targeted properties and diverse functionalities.


METHODS
Applying the first principles in physical science for powders, fine guest particles can be homogeneously dispersed over the surface of larger host particles to develop functionalised particles. Multiple functionalities can be modified including: flowability, dispersibility, fluidisation, homogeneity, content uniformity and dissolution profile. The current publication seeks to understand the fundamental underpinning principles and science governing dry coating process, evaluate key technologies developed to produce functionalised particles along with outlining their advantages, limitations and applications and discusses in detail the resultant functionalities and their applications.


CONCLUSIONS
Dry particle coating is a promising solvent-free manufacturing technology to produce particles with targeted functionalities. Progress within this area requires the development of continuous processing devices that can overcome challenges encountered with current technologies such as heat generation and particle attrition. Growth within this field requires extensive research to further understand the impact of process design and material properties on resultant functionalities.
a Aston School of Pharmacy, Aston University , Birmingham, UK +44 0121 204 4183 ; a.u.r.mohammed@aston.ac.uk.
Eman Z
EZ
Dahmash
a Aston School of Pharmacy, Aston University , Birmingham, UK +44 0121 204 4183 ; a.u.r.mohammed@aston.ac.uk.
Afzal R
AR
Mohammed
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D005079:Excipients; D006801:Humans; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011208:Powders
D005079:Excipients; D004364:Pharmaceutical Preparations; D011208:Powders
dry-powder coating; functionalised particles; guest; host; hybrid mixing; shear force