High-fat Diet Promotes Cardiac Remodeling in an Experimental Model of Obesity.
BACKGROUND
Although nutritional, metabolic and cardiovascular abnormalities are commonly seen in experimental studies of obesity, it is uncertain whether these effects result from the treatment or from body adiposity.


OBJECTIVE
To evaluate the influence of treatment and body composition on metabolic and cardiovascular aspects in rats receiving high saturated fat diet.


METHODS
Sixteen Wistar rats were used, distributed into two groups, the control (C) group, treated with isocaloric diet (2.93 kcal/g) and an obese (OB) group, treated with high-fat diet (3.64 kcal/g). The study period was 20 weeks. Analyses of nutritional behavior, body composition, glycemia, cholesterolemia, lipemia, systolic arterial pressure, echocardiography, and cardiac histology were performed.


RESULTS
High-fat diet associates with manifestations of obesity, accompanied by changes in glycemia, cardiomyocyte hypertrophy, and myocardial interstitial fibrosis. After adjusting for adiposity, the metabolic effects were normalized, whereas differences in morphometric changes between groups were maintained.


CONCLUSIONS
It was concluded that adiposity body composition has a stronger association with metabolic disturbances in obese rodents, whereas the high-fat dietary intervention is found to be more related to cardiac morphological changes in experimental models of diet-induced obesity.
Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Fernando
F
Martins
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Dijon Henrique Salomé
DH
Campos
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Luana Urbano
LU
Pagan
Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Paula Felippe
PF
Martinez
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Katashi
K
Okoshi
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Marina Politi
MP
Okoshi
Instituto de Biociências de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Carlos Roberto
CR
Padovani
Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Albert Schiaveto de
AS
Souza
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Antonio Carlos
AC
Cicogna
Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Silvio Assis de
SA
Oliveira-Junior
D000273:Adipose Tissue / Q000503:physiopathology; D000818:Animals; D062186:Arterial Pressure / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000009:adverse effects*; D004195:Disease Models, Animal; D004452:Echocardiography; D002149:Energy Intake; D006943:Hyperglycemia; D008297:Male; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology*; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013997:Time Factors; D020257:Ventricular Remodeling / Q000502:physiology*
D001786:Blood Glucose; D004041:Dietary Fats; D002784:Cholesterol