H. pylori GPS: Modulating Host Metabolites for Location Sensing.
Almost 20 years ago, urea was described as a chemotaxis attractant for Helicobacter pylori. In this issue of Cell Host & Microbe, Huang et al. (2015) report that H. pylori employs its urease enzyme to destroy urea to bring the concentration into a range that provokes an attractant response.
Department of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Daniela
D
Keilberg
Department of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: ottemann@ucsc.edu.
Karen M
KM
Ottemann
D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D002633:Chemotaxis; D004848:Epithelium / Q000382:microbiology*; D005753:Gastric Mucosa / Q000382:microbiology*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D014508:Urea / Q000378:metabolism*; D014510:Urease / Q000378:metabolism*
D001426:Bacterial Proteins; D014508:Urea; D014510:Urease