Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications.
Current advances in biomaterial fabrication techniques have broadened their application in different realms of biomedical engineering, spanning from drug delivery to tissue engineering. The success of biomaterials depends highly on the ability to modulate cell and tissue responses, including cell adhesion, as well as induction of repair and immune processes. Thus, most recent approaches in the field have concentrated on functionalizing biomaterials with different biomolecules intended to evoke cell- and tissue-specific reactions. Marine mussels produce mussel adhesive proteins (MAPs), which help them strongly attach to different surfaces, even under wet conditions in the ocean. Inspired by mussel adhesiveness, scientists discovered that dopamine undergoes self-polymerization at alkaline conditions. This reaction provides a universal coating for metals, polymers, and ceramics, regardless of their chemical and physical properties. Furthermore, this polymerized layer is enriched with catechol groups that enable immobilization of primary amine or thiol-based biomolecules via a simple dipping process. Herein, this review explores the versatile surface modification techniques that have recently been exploited in tissue engineering and summarizes polydopamine polymerization mechanisms, coating process parameters, and effects on substrate properties. A brief discussion of polydopamine-based reactions in the context of engineering various tissue types, including bone, blood vessels, cartilage, nerves, and muscle, is also provided.
Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University , Seoul 133-791, Republic of Korea.|BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University , Seoul 133-791, Republic of Korea.
Sajeesh Kumar
SK
Madhurakkat Perikamana
Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University , Seoul 133-791, Republic of Korea.|BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University , Seoul 133-791, Republic of Korea.
Jinkyu
J
Lee
Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University , Seoul 133-791, Republic of Korea.|BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University , Seoul 133-791, Republic of Korea.
Yu Bin
YB
Lee
Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University , Seoul 133-791, Republic of Korea.|BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University , Seoul 133-791, Republic of Korea.
Young Min
YM
Shin
Department of Bioengineering, Rice University , Houston, Texas 77030, United States.
Esther J
EJ
Lee
Department of Bioengineering, Rice University , Houston, Texas 77030, United States.|Department of Chemical and Biomolecular Engineering, Rice University , Houston, Texas 77030, United States.
Antonios G
AG
Mikos
Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University , Seoul 133-791, Republic of Korea.|BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University , Seoul 133-791, Republic of Korea.
Heungsoo
H
Shin
D000818:Animals; D049872:Bivalvia / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004298:Dopamine / Q000737:chemistry*; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
D020099:Coated Materials, Biocompatible; D007211:Indoles; D011108:Polymers; D011506:Proteins; C037403:adhesive protein, mussel; C568283:polydopamine; D004298:Dopamine