Synthesis of Isoquinolones Using Visible-Light-Promoted Denitrogenative Alkyne Insertion of 1,2,3-Benzotriazinones.
A visible-light-promoted regioselective denitrogenative insertion of terminal alkynes into 1,2,3-benzotriazinones is reported. This mechanistically novel process allows the synthesis of substituted isoquinolones in satisfactory isolated yields (24 examples, 46-84% yield) at room temperature under visible-light irradiation with the assistance of a photocatalyst. The proposed single-electron-transfer pathway was supported by TEMPO trapping, radical clock experiments, and Stern-Volmer analysis.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
Hao
H
Wang
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
Shouyun
S
Yu