Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs.
N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid metabolism after oral GlcNAc administration in dogs. Results showed that plasma levels of ectoine were significantly higher after oral administration of GlcNAc than prior to administration (p < 0.001). To our knowledge, there have been no reports of increased ectoine concentrations in the plasma. The mechanism by which GlcNAc administration leads to increased ectoine plasma concentration remains unclear; future studies are required to clarify this mechanism.
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan. tosaki@muses.tottori-u.ac.jp.
Tomohiro
T
Osaki
Koyo Chemical Co. Ltd., 1-17 Taiyuji-cho, Kita-ku, Osaka 530-0051, Japan. kurozumi@koyo-chemical.co.jp.
Seiji
S
Kurozumi
Koyo Chemical Co. Ltd., 1-17 Taiyuji-cho, Kita-ku, Osaka 530-0051, Japan. sato@koyo-chemical.co.jp.
Kimihiko
K
Sato
Koyo Chemical Co. Ltd., 1-17 Taiyuji-cho, Kita-ku, Osaka 530-0051, Japan. taro.terashi@koyo-chemical.co.jp.
Taro
T
Terashi
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan. kazu-azuma@muses.tottori-u.ac.jp.
Kazuo
K
Azuma
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan. ymurahata@muses.tottori-u.ac.jp.
Yusuke
Y
Murahata
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan. tsuka@muses.tottori-u.ac.jp.
Takeshi
T
Tsuka
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan. taromobile@me.com.
Norihiko
N
Ito
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan. imagawat@muses.tottori-u.ac.jp.
Tomohiro
T
Imagawa
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan. saburominami@ncn-t.net.
Saburo
S
Minami
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan. yokamoto@muses.tottori-u.ac.jp.
Yoshiharu
Y
Okamoto
D000117:Acetylglucosamine / Q000008:administration & dosage*; D000284:Administration, Oral; D000596:Amino Acids / Q000378:metabolism; D000599:Amino Acids, Diamino / Q000097:blood; D000818:Animals; D004285:Dogs; D055442:Metabolome / Q000187:drug effects*; D055432:Metabolomics / Q000379:methods; D009005:Monosaccharides / Q000008:administration & dosage; D010949:Plasma / Q000187:drug effects* / Q000378:metabolism*
D000596:Amino Acids; D000599:Amino Acids, Diamino; D009005:Monosaccharides; C045628:ectoine; D000117:Acetylglucosamine
N-acetyl-d-glucosamine hydrochloride; TGF-beta; amino acid; cartilage regeneration; dog