[Neuropathic pain. How to open the blackbox].
This article, without presuming to be comprehensive, gives a brief outline of the development of research on neuropathic pain in Germany. Current clinical research on this subject focusses on the validation of human models, patient phenotyping, mechanism-based classification and treatment as well as on molecular pathomechanisms. This clinical research is based to a large extent on the work of several internationally recognized basic researchers in the 1990s. In particular, findings from system physiology led to the analysis of clinical phenotypes and the underlying pathophysiology. In parallel, basic research achieved international top levels through the development of innovative methods. Close cooperation, building of consortia and European networking made major contributions to the success of this research.
Abteilung für Schmerzmedizin, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Bürkle-de-la-Camp Platz 1, 44789, Bochum, Deutschland. christoph.maier@rub.de.
C
C
Maier
Sektion Schmerzforschung und -therapie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland.
R
R
Baron
Neurologische Klinik, Universitätsklinikum Würzburg, Würzburg, Deutschland.
C
C
Sommer
D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D005544:Forecasting; D005858:Germany; D006801:Humans; D009437:Neuralgia / Q000503:physiopathology* / Q000628:therapy*; D009473:Neuronal Plasticity / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D059408:Pain Management; D017933:Peripheral Nervous System / Q000503:physiopathology*; D011785:Quality Assurance, Health Care / Q000639:trends; D057170:Translational Research, Biomedical / Q000639:trends
Mechanism-based treatment; Models, animal; Neuroinflammation; Systems physiology; Translational medical research