Five new compounds from the fungus Ganoderma petchii.
The fungal species of the genus Ganoderma attracted great interest in the last decades. Our recent investigation on Ganoderma petchii afforded five new compounds, (-)-petchioics A and B (1 and 2), petchiates A and B (3 and 4), petchine (5), and a known compound. The structures of the new compounds were elucidated on the basis of spectroscopic data. The absolute configurations of 1 and 2 were assigned by computational methods. Biological activities of these isolates towards human cancer cells, COX-1/2, and influenza virus were evaluated.
Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
Wei-Feng
WF
Dai
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, PR China.
Ping-Xia
PX
Guo
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, PR China.
Zheng-Chao
ZC
Tu
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China. Electronic address: rongtaolikm@163.com.
Rong-Tao
RT
Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: yxcheng@mail.kib.ac.cn.
Yong-Xian
YX
Cheng
D000085:Acetates / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D002264:Carboxylic Acids / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D003509:Cyclohexanecarboxylic Acids / Q000737:chemistry / Q000302:isolation & purification; D016861:Cyclooxygenase Inhibitors; D004285:Dogs; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D061985:Madin Darby Canine Kidney Cells; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification
D000085:Acetates; D002264:Carboxylic Acids; D003509:Cyclohexanecarboxylic Acids; D016861:Cyclooxygenase Inhibitors; D005663:Furans; D011725:Pyridines; D011753:Pyrones
Anti-influenza virus; COX-1/2; Cytotoxicity; Fungus; Ganoderma petchii