No Evidence of Human Papilloma Virus Infection in Basal Cell Carcinoma.
BACKGROUND
Basal cell carcinoma (BCC) is the most common skin cancer among whites, and several risk factors have been discussed in itsdevelopment and progress. Detection of human papilloma virus (HPV) deoxyribonucleic acid (DNA) BCCs in some studies suggests that the virus may play a role in the pathogenesis of this disease. Several molecular studies showed conflicting reports.


OBJECTIVE
The purpose of this study was to investigate the association between HPV and BCC using polymerase chain reaction (PCR).


METHODS
HPV DNA detection was done for 42 paraffin-embedded tissue specimens of BCC and 42 normal skin samples around the lesions by PCR using GP5+/GP6+ primers.


RESULTS
HPV DNA was not found in any of the 42 samples of BCC, and only one normal skin sample around the lesions was positive for HPV DNA by PCR.


CONCLUSIONS
In this study, no statistically significant difference was seen between the presence of HPV DNA in BCC and normal skin around the lesion, and HPV is not likely to have an important role in pathogenesis of BCC.
Department of Dermatology, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Yalda
Y
Nahidi
Department of Pathology, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Naser Tayyebi
NT
Meibodi
Department of Virology, Research Center for Microbiology and Virology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra
Z
Meshkat
Department of Faculty of Health, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Habibollah
H
Esmaili
Department of Pathology, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Samaneh
S
Jahanfakhr
Basal cell carcinoma; human papillomavirus; polymerase chain reaction