Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina.
OBJECTIVE
To investigate association of two LPIN1 gene variations with main traits of metabolic syndrome (MS) (waist circumference, body mass index, blood pressure, triglycerides, HDL-cholesterol and fasting glucose levels) in population from Bosnia and Herzegovina.


METHODS
This study included 43 patients with metabolic syndrome and 43 healthy controls from General Hospital in Tešanj, Bosnia and Herzegovina. Subjects were genotyped for two LPIN1 gene variations (rs11693809: C>T and rs2716610: C>T) by real time PCR method.


RESULTS
In control subjects LPIN1 polymorphism, rs2716610: C>T, was significantly associated with a lower body mass index (BMI) (p=0.008) and waist circumference (p=0.008). The second analyzed rs11693809: C>T polymorphism was associated with lower blood HbA1c levels (p=0.048) in a group of MS patients.


CONCLUSIONS
Results of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS.
Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Tamer
T
Bego
Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Tanja
T
Dujić
Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Barbara
B
Mlinar
Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo.
Sabina
S
Semiz
Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Maja
M
Malenica
General Hospital of Tešanj, Tešanj, Department of Pathophysiology,Faculty of Pharmacy; University Sarajevo, Sarajevo; Bosnia and Herzegovina.
Besim
B
Prnjavorac
Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Barbara
B
Ostanek
Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Janja
J
Marc
Bosnalijek, Pharmaceutical and Chemical Industry, Joint Stock Company, Sarajevo.
Anida
A
Čaušević-Ramoševac
Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Adlija
A
Čaušević
D000328:Adult; D015992:Body Mass Index; D017522:Bosnia and Herzegovina; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D010711:Phosphatidate Phosphatase / Q000235:genetics*; D011110:Polymorphism, Genetic
D006442:Glycated Hemoglobin; D010711:Phosphatidate Phosphatase; C517652:hemoglobin A1c protein, human; C485999:LPIN1 protein, human
LPIN1 gene; gene variations; markers; metabolic syndrome