The Role of Long Intergenic Noncoding RNA p21 in Vascular Endothelial Cells.
Large intergenic long noncoding RNA p21 (lincRNA-p21) has recently shown to play an important role in biological functions. However, the biological role of lincRNA-p21 in vascular endothelial cells remains unclear. In the present study, we investigated the role of lincRNA-p21 in vascular endothelial cells through gain- and loss-of-function studies and found that lincRNA-p21 promoted cell apoptosis and induced cell cycle progression. Furthermore, lincRNA-p21 acted as an endogenous sponge by directly binding to miR-130b and decreased miR-130b expression. In addition, miR-130b reversed the inhibitory effect of lincRNA-p21 on the growth of vascular endothelial cells. Taken together, our data highlight the pivotal role of lincRNA-p21 in the growth of vascular endothelial cells.
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Chao
C
He
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Jia-Wang
JW
Ding
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Song
S
Li
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Hui
H
Wu
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Yu-Rong
YR
Jiang
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Wei
W
Yang
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Lin
L
Teng
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Jun
J
Yang
Institute of Cardiology, Medical Science College of China Three Gorges University , Yichang, Hubei Province, People's Republic of China .
Jian
J
Yang
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D002460:Cell Line; D002467:Cell Nucleus / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D003593:Cytoplasm / Q000235:genetics; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000502:physiology*
C582652:MIRN130 microRNA, mouse; D035683:MicroRNAs; D062085:RNA, Long Noncoding