A CTCF Code for 3D Genome Architecture.
The architectural protein CTCF plays a complex role in decoding the functional output of the genome. Guo et al. now show that the orientation of a CTCF site restricts its choice of interacting partner, thus creating a code that predicts the three-dimensional organization of the genome. We propose a DNA extrusion model to account for orientation-specific loop formation.
Department of Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA 30322, USA.
Michael H
MH
Nichols
Department of Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA 30322, USA. Electronic address: vcorces@emory.edu.
Victor G
VG
Corces
D000818:Animals; D002875:Chromosomes / Q000378:metabolism*; D005821:Genetic Techniques; D006801:Humans; D012097:Repressor Proteins / Q000378:metabolism*
D012097:Repressor Proteins