Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia.
OBJECTIVE
Diabetes mellitus is a growing health problem worldwide. This study aimed to describe dysglycaemia and determine the impact of body composition and clinical and lifestyle factors on the risk of progression or regression from impaired fasting glucose (IFG) to diabetes or normoglycaemia in Australian women.


METHODS
This study included 1167 women, aged 20-94 years, enrolled in the Geelong Osteoporosis Study. Multivariable logistic regression was used to identify predictors for progression to diabetes or regression to normoglycaemia (from IFG), over 10 years of follow-up.


RESULTS
At baseline the proportion of women with IFG was 33.8% and 6.5% had diabetes. Those with fasting dysglycaemia had higher obesity-related factors, lower serum HDL cholesterol, and lower physical activity. Over a decade, the incidence of progression from IFG to diabetes was 18.1 per 1,000 person-years (95% CI, 10.7-28.2). Fasting plasma glucose and serum triglycerides were important factors in both progression to diabetes and regression to normoglycaemia.


CONCLUSIONS
Our results show a transitional process; those with IFG had risk factors intermediate to normoglycaemics and those with diabetes. This investigation may help target interventions to those with IFG at high risk of progression to diabetes and thereby prevent cases of diabetes.
School of Medicine, Deakin University, 285 Ryrie Street, Geelong, VIC 3220, Australia.
L
L
de Abreu
School of Medicine, Deakin University, 285 Ryrie Street, Geelong, VIC 3220, Australia.
Kara L
KL
Holloway
School of Medicine, Deakin University, 285 Ryrie Street, Geelong, VIC 3220, Australia ; Department of Medicine, NorthWest Academic Centre, The University of Melbourne, 176 Furlong Road, St Albans, VIC 3021, Australia ; Barwon Health, Ryrie Street, Geelong, VIC 3220, Australia.
Mark A
MA
Kotowicz
School of Medicine, Deakin University, 285 Ryrie Street, Geelong, VIC 3220, Australia ; Department of Medicine, NorthWest Academic Centre, The University of Melbourne, 176 Furlong Road, St Albans, VIC 3021, Australia ; Barwon Health, Ryrie Street, Geelong, VIC 3220, Australia.
Julie A
JA
Pasco
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia; D001786:Blood Glucose / Q000032:analysis*; D001823:Body Composition; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D008019:Life Style; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications; D015995:Prevalence; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides