ORGANIC INFLAMMATORY RESPONSE TO REDUCED PREOPERATIVE FASTING TIME, WITH A CARBOHYDRATE AND PROTEIN ENRICHED SOLUTION; A RANDOMIZED TRIAL.
BACKGROUND
this study aims to assess the organic inflammatory response of the video laparoscopic cholecystectomy, with abbreviation of the preoperative fasting to 2h using a carbohydrate and protein enriched solution.


METHODS
this is a randomized, prospective study with patients divided into the following 2 groups: group A, conventional fasting and group B, 2h abbreviated fasting with oral ingestion of a carbohydrate and protein solution. Serum glucose, insulin, interleukin 1, and TNF-α were mesasured before ingestion of the solution, during induction of anesthesia, and 4 h after the end of surgery.


RESULTS
thirty-eight patients completed the study without presenting pulmonary complications associated with bronchoaspiration. The postoperative HOMA-IR variance was greater in group A (p = 0.001).


CONCLUSIONS
the abbreviation of preoperative fasting for 2 h, using carbohydrate and protein enriched solutions, is safe, reduces insulin resistance, and does not increase the risk of bronchoaspiration.
Oncologic Surgeon of the Gaffreé and Guinle University Hospital, Rio de Janeiro.. guilhermeravanini@gmail.com.
Guilherme
G
de Andrade Gagheggi Ravanini
General Surgeon, Professor of the Rio de Janeiro School of Medicine and Surgery, Chief of Surgery Department B of the Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro.. guilhermeravanini@gmail.com.
Pedro Eder
PE
Portari Filho
General Surgeon of the Hospital of the State Officials of Rio de Janeiro, Rio de Janeiro.. guilhermeravanini@gmail.com.
Renato
R
Abrantes Luna
Graduate Student of Medicine, Federal University of the State of Rio de Janeiro -UNIRIO (Brazil).. guilhermeravanini@gmail.com.
Vinicius
V
Almeida de Oliveira
D000328:Adult; D001786:Blood Glucose; D002241:Carbohydrates; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects; D005215:Fasting; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D018529:Nutritional Support; D061646:Operative Time; D011183:Postoperative Complications; D011300:Preoperative Care; D011506:Proteins
D001786:Blood Glucose; D002241:Carbohydrates; D018836:Inflammation Mediators; D007328:Insulin; D011506:Proteins