An unusual case of colonic adenocarcinoma development in the region of disseminating lobular breast carcinoma infiltration: diagnostic approach and review of the literature.
We present an unusual case of colon cancer development in bowel segment involved with lobular breast carcinoma infiltration. 80 year old Caucasian woman was diagnosed with right colon carcinoma due to rectal bleeding and obstructive symptoms. She had nine years clinical history of lobular, well differentiated breast cancer with five years of postoperative tamoxifen therapy, disseminating to bones and pleural cavities two years prior to hemicolectomy. On microscopic examination under the colonic adenocarcinoma and in the whole length of the resected bowel segment, massive infiltration of lobular carcinoma was discovered. She remains alive under the palliative hormone and chemotherapy. In our paper we discuss clinical and pathological issues concerning metastases of breast cancer into the gastrointestinal tract as well as rare colocalization of colonic and breast cancers within the same intestinal segment. Review of the literature is also presented accordingly.
Department of Gastroenterology, Hepatology and Clinical Oncology, Center of Postgraduate Medical Education Warsaw, Poland ; Department of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Warsaw, Poland.
Andrzej
A
Mroz
Clinical Department of Oncology and Hematology, Central Clinical Hospital of The Ministry of Interior in Warsaw Poland.
Miroslaw
M
Kiedrowski
D000230:Adenocarcinoma / Q000473:pathology*; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000556:secondary*; D003110:Colonic Neoplasms / Q000473:pathology* / Q000556:secondary*; D005260:Female; D006801:Humans
Lobular breast carcinoma; coexistence; colonic adenocarcinoma; diagnosis