Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60.
Individuals infected with HIV are living longer due to effective treatment with combination antiretroviral therapy (cART). Despite these advances, HIV-associated neurocognitive disorders (HAND) remain prevalent. In this study, we analyzed resting state functional connectivity (rs-fc) data from HIV-infected and matched HIV-uninfected adults aged 60 years and older to determine associations between HIV status, neuropsychological performance, and clinical variables. HIV-infected participants with detectable plasma HIV RNA exhibited decreased rs-fc within the salience (SAL) network compared to HIV-infected participants with suppressed plasma HIV RNA. We did not identify differences in rs-fc within HIV-infected individuals by HAND status. Our analysis identifies focal deficits in the SAL network that may be mitigated with suppression of plasma virus. However, these findings suggest that rs-fc may not be sensitive as a marker of HAND among individuals with suppressed plasma viral loads.
Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Anika
A
Guha
Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Liang
L
Wang
Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Aaron
A
Tanenbaum
Memory and Aging Center, Sandler Neurosciences Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Pardis
P
Esmaeili-Firidouni
Memory and Aging Center, Sandler Neurosciences Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Lauren A
LA
Wendelken
Memory and Aging Center, Sandler Neurosciences Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Edgar
E
Busovaca
Memory and Aging Center, Sandler Neurosciences Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Katherine
K
Clifford
Memory and Aging Center, Sandler Neurosciences Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Akash
A
Desai
Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.|Department of Biomedical Engineering, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.|Department of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Beau M
BM
Ances
Memory and Aging Center, Sandler Neurosciences Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA. Vvalcour@memory.ucsf.edu.
Victor
V
Valcour
D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D001921:Brain / Q000503:physiopathology* / Q000821:virology; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000473:pathology / Q000821:virology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology; D005260:Female; D059907:Functional Neuroimaging; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000187:drug effects / Q000503:physiopathology* / Q000821:virology; D009483:Neuropsychological Tests; D012367:RNA, Viral / Q000037:antagonists & inhibitors / Q000097:blood*; D019562:Viral Load / Q000187:drug effects
D019380:Anti-HIV Agents; D012367:RNA, Viral
Cognition; Functional MRI; HIV; Network connectivity