Common Variants in Serum/Glucocorticoid Regulated Kinase 1 (SGK1) and Blood Pressure Responses to Dietary Sodium or Potassium Interventions: A family-Based Association Study.
OBJECTIVE
Serum/Glucocorticoid Regulated Kinase 1 (SGK1) plays a significant role in regulating renal Na(+) reabsorption, K(+) secretion, and blood pressure (BP). This study aimed to assess the association of common genetic variants in the SGK1 gene with BP responses to controlled dietary sodium or potassium interventions.


METHODS
A total of 334 subjects from 124 families were recruited from the rural areas of northern China. After a three-day baseline observation, they were sequentially maintained a seven-day low-sodium diet (3g/day of NaCl or 51.3 mmol/day of sodium), a seven-day high-sodium diet (18 g/day of NaCl or 307.8 mmol/day of sodium) and a seven-day high-sodium plus potassium supplementation intervention (4.5 g/day of KCl or 60 mmol/day of potassium). Six single-nucleotide polymorphisms (SNPs) in the SGK1 gene were selected.


RESULTS
After adjustment for multiple testing, SNP rs9376026 was significantly associated with diastolic BP (DBP) and mean arterial pressure (MAP) responses to low-sodium intervention (P = 0.018 and 0.022, respectively). However, the associations between selected SNPs in the SGK1 gene and BP responses to high-sodium or high-sodium plus potassium-supplementation intervention did not reach statistical significance. In addition, SNP rs9389154 and two other SNPs (rs1763509 and rs9376026) were associated respectively with systolic BP (SBP) and DBP at baseline (P = 0.040, 0.032, and 0.031, respectively). SNP rs3813344 was significantly associated with SBP, DBP, and MAP (P = 0.049, 0.015 and 0.018, respectively).


CONCLUSIONS
Our study indicates that the genetic polymorphism in the SGK1 gene is significantly associated with BP responses to dietary sodium intervention.
Department of Cardiovascular medicine, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, P.R. China.
Chao
C
Chu
Yang
Y
Wang
Man
M
Wang
Jian-Jun
JJ
Mu
Fu-Qiang
FQ
Liu
Lan
L
Wang
Ke-Yu
KY
Ren
Dan
D
Wang
Zu-Yi
ZY
Yuan
D000293:Adolescent; D000328:Adult; D062186:Arterial Pressure / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002681:China / Q000453:epidemiology; D004032:Diet; D004039:Diet, Sodium-Restricted; D005190:Family; D005260:Female; D005787:Gene Frequency; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017419:Potassium, Dietary / Q000494:pharmacology*; D058246:Prehypertension / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012424:Rural Population; D012982:Sodium, Dietary / Q000494:pharmacology*; D055815:Young Adult; D000099184:Serum-Glucocorticoid Regulated Kinases
D017874:Immediate-Early Proteins; D017419:Potassium, Dietary; D017346:Protein Serine-Threonine Kinases; D012982:Sodium, Dietary; D000099184:Serum-Glucocorticoid Regulated Kinases