Sonochemical Synthesis of Hydrophilic Drug Loaded Multifunctional Bovine Serum Albumin Nanocapsules.
A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs), and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excellent magnetic responsive ability. Moreover, high-dose hydrophilic drugs could be loaded into the MBNCs. As carriers, HD-loaded MBNCs also show attractive redox-responsive controlled release ability for hydrophilic drugs and could be internalized selectively by the tumor cells through the folate-mediated endocytosis.
College of Chemistry and ‡College of Life Sciences, Jilin University , Changchun 130012, China.
Zhanfeng
Z
Li
College of Chemistry and ‡College of Life Sciences, Jilin University , Changchun 130012, China.
Ting
T
Yang
College of Chemistry and ‡College of Life Sciences, Jilin University , Changchun 130012, China.
Chunming
C
Lin
College of Chemistry and ‡College of Life Sciences, Jilin University , Changchun 130012, China.
Quanshun
Q
Li
College of Chemistry and ‡College of Life Sciences, Jilin University , Changchun 130012, China.
Songfeng
S
Liu
College of Chemistry and ‡College of Life Sciences, Jilin University , Changchun 130012, China.
Fengzhi
F
Xu
College of Chemistry and ‡College of Life Sciences, Jilin University , Changchun 130012, China.
Hongyan
H
Wang
College of Chemistry and ‡College of Life Sciences, Jilin University , Changchun 130012, China.
Xuejun
X
Cui
D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations; D005434:Flow Cytometry; D005492:Folic Acid / Q000494:pharmacology; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D060328:Magnetic Phenomena; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013010:Sonication / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet
D003692:Delayed-Action Preparations; D053769:Nanocapsules; D012710:Serum Albumin, Bovine; D005492:Folic Acid; D005978:Glutathione
hydrophilic drug; magnetic responsive; nanocapsule; redox-responsive; sonochemical