Extremely High Two-Photon Absorbing Graphene Oxide for Imaging of Tumor Cells in the Second Biological Window.
Cancer, a life-threatening disease, has become a global pandemic. Targeted tumor imaging using near-infrared (NIR) light is the key to improve the penetration depth and it is highly promising for clinical tumor diagnostics. Driven by this need, in this Letter we have reported aptamer conjugated graphene oxide-based two-photon imaging of breast tumor cells selectively. Reported data indicate that there is an extremely high two-photon absorption from aptamer conjugated graphene oxide (σ2PA = 46890 GM). Experimental data show that two-photon luminescence signal remains almost unchanged even after 2 h of illuminations. Reported results show that S6 RNA aptamers conjugated graphene oxide-based two-photon fluorescence can be used for selective two-photon imaging of SK-BR-3 breast tumor cell in second biological transparency windows using 1100 nm wavelength. Experimental data demonstrate that it is highly capable of distinguishing targeted breast cancer SK-BR-3 cells from other nontargeted MDA-MB-231 breast cancer cells.
Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States.
Avijit
A
Pramanik
Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States.
Suhash Reddy
SR
Chavva
Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States.
Zhen
Z
Fan
Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States.
Sudarson Sekhar
SS
Sinha
Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States.
Bhanu Priya Viraka
BP
Nellore
Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States.
Paresh Chandra
PC
Ray
graphene oxide; near IR imaging; selective tumor cell imaging; two photon absorption