Ictal Magnetic Source Imaging in Presurgical Assessment.
Ictal MEG recordings constitute rare data. The objective of this study was to evaluate ictal magnetic source localization (MSI), using two algorithms: linearly constrained minimum variance (LCMV), a beamforming technique and equivalent current dipole (ECD). Ictal MSI was studied in six patients. Three of them were undergoing post-operative re-evaluation. For all patients, results were validated by the stereoelectroencephalographic (SEEG) definition of the epileptogenic zone (EZ). EZ was quantified using the epileptogenicity index (EI) method, which accounts for both the propensity of a brain area to generate rapid discharges and the time for this area to become involved in the seizure. EI values range from 0 (no epileptogenicity) to 1 (maximal epileptogenicity). Levels of concordance between ictal MSI and EZ were determined as follows: A: ictal MSI localized the site whose value EI = 1, B: MSI localized a part of the EZ (not corresponding to the maximal value of EI = 1), C: a region could be identified on ictal MSI but not on SEEG, D: a region could be identified on SEEG but not on MSI, E: different regions were localized on MSI and SEEG. Ictal MEG pattern consisted of rhythmic activities between 10 and 20 Hz for all patients. For LCMV (first maxima), levels of concordance were A (two cases), B (two cases) and E (two cases). For ECD fitted on each time point separately (location characterized by the best goodness-of-fit value), levels of concordance were A (one case), B (one case), D (three cases) and E (one case). For ECD calculated for the whole time window, levels of concordance were A (two cases) and D (four cases). Source localization methods performed on rhythmic patterns can localize the EZ as validated by SEEG. In terms of concordance, LCMV was superior to ECD. In some cases, LCMV allows extraction of several maxima that could reflect ictal dynamics. In a medial temporal lobe epilepsy case, ictal MSI indicated an area of delayed propagation and was non-contributory to the presurgical assessment.
Institut de Neurosciences des Systèmes, INSERM UMR 1106, 13005, Marseille, France.|Faculté de Médecine, Aix Marseille Université, 13005, Marseille, France.
Jean-Michel
JM
Badier
Institut de Neurosciences des Systèmes, INSERM UMR 1106, 13005, Marseille, France.|Faculté de Médecine, Aix Marseille Université, 13005, Marseille, France.
Christian-George
CG
Bénar
Institut de Neurosciences des Systèmes, INSERM UMR 1106, 13005, Marseille, France.|Faculté de Médecine, Aix Marseille Université, 13005, Marseille, France.
Michael
M
Woodman
Service de Neurologie, Unidade Local de Saúde de Matosinhos, Rua Dr. Eduardo Torres, 4464-513, Senhora da Hora, Portugal.
Catarina
C
Cruto
Institut de Neurosciences des Systèmes, INSERM UMR 1106, 13005, Marseille, France.|Faculté de Médecine, Aix Marseille Université, 13005, Marseille, France.|Service de Neurophysiologie Clinique, Hôpital de la Timone, AP-HM, 264 rue Saint Pierre, 13005, Marseille, France.
Patrick
P
Chauvel
Institut de Neurosciences des Systèmes, INSERM UMR 1106, 13005, Marseille, France.|Faculté de Médecine, Aix Marseille Université, 13005, Marseille, France.|Service de Neurophysiologie Clinique, Hôpital de la Timone, AP-HM, 264 rue Saint Pierre, 13005, Marseille, France.
Fabrice
F
Bartolomei
Institut de Neurosciences des Systèmes, INSERM UMR 1106, 13005, Marseille, France. martine.gavaret@ap-hm.fr.|Faculté de Médecine, Aix Marseille Université, 13005, Marseille, France. martine.gavaret@ap-hm.fr.|Service de Neurophysiologie Clinique, Hôpital de la Timone, AP-HM, 264 rue Saint Pierre, 13005, Marseille, France. martine.gavaret@ap-hm.fr.
Martine
M
Gavaret
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
Epilepsy; MEG; Seizures; Source localization