Ambient carbon monoxide associated with alleviated respiratory inflammation in healthy young adults.
There is increasing controversy on whether acute exposure to ambient carbon monoxide (CO) is hazardous on respiratory health. We therefore performed a longitudinal panel study to evaluate the acute effects of ambient CO on fractional exhaled nitric oxide (FeNO), a well-established biomarker of airway inflammation. We completed 4-6 rounds of health examinations among 75 healthy young adults during April to June in 2013 in Shanghai, China. We applied the linear mixed-effect model to investigate the short-term associations between CO and FeNO. CO exposure during 2-72 h preceding health tests was significantly associated with decreased FeNO levels. For example, an interquartile range increase (0.3 mg/m(3)) of 2-h CO exposure corresponded to 10.6% decrease in FeNO. This association remained when controlling for the concomitant exposure to co-pollutants. This study provided support that short-term exposure to ambient CO might be related with reduced levels of FeNO, a biomarker of lower airway inflammation.
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China.
Zhuohui
Z
Zhao
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Fudan University, Shanghai, China.
Renjie
R
Chen
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China.
Zhijing
Z
Lin
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Fudan University, Shanghai, China.
Jing
J
Cai
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China.
Yingying
Y
Yang
Shanghai Key Laboratory of Meteorology and Health, Shanghai, China.
Dandan
D
Yang
Department of Environmental and Occupational Medicine, Uppsala University, Uppsala, Sweden.
Dan
D
Norback
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Fudan University, Shanghai, China. Electronic address: haidongkan@gmail.com.
Haidong
H
Kan
D000328:Adult; D000393:Air Pollutants / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests; D002248:Carbon Monoxide / Q000032:analysis*; D002681:China; D045853:Exhalation; D005260:Female; D006801:Humans; D007249:Inflammation; D019570:Inhalation Exposure / Q000032:analysis*; D008137:Longitudinal Studies; D008297:Male; D009569:Nitric Oxide / Q000032:analysis; D012137:Respiratory System / Q000187:drug effects* / Q000276:immunology; D012140:Respiratory Tract Diseases / Q000453:epidemiology* / Q000276:immunology; D055815:Young Adult
D000393:Air Pollutants; D015415:Biomarkers; D009569:Nitric Oxide; D002248:Carbon Monoxide
Air pollution; Carbon monoxide; Panel study; Respiratory inflammation