Upregulated expression of CD30 protein in sclerosing angiomatoid nodular transformation (SANT): studies of additional 4 cases and analyses of 6 cases previously published cases.
Sclerosing angiomatoid nodular transformation (SANT) of spleen is a benign lesion with a distinct morphological and immunohisochemical characteristics. Only Weinred I et al (Virchow Arch 451: 73-9, 2007) reported 6 cases of SANT expressing CD30, of which positive for EBV by in situ hybridization (EBER). 4 cases of SANT were added to investigate the clinicopathological features and focused on the expression of CD30 and EBER combined with the previously published literature. Histologically, individual angiomatoid nodules were sharply delineated by fibrocollagenous stroma with numerous vascular lumens and surrounded by a different population of spindle and ovoid cells. Angiomatoid nodules of all of the 4 cases heterogeneously expressed CD34, CD8, CD68 and diffusely demonstrated CD31 and CD30, but none were positive for EBER. We added these cases with reviewed literature to emphasize and verify the fact that upregulated expression of CD30 in SANT is quite common, which should be taken into consideration when making differential diagnosis.
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Jun
J
Zhou
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Dandan
D
Zhang
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Guiming
G
Hu
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Xiangyu
X
Zheng
Department of Pathology, Jingling Hospital of Nanjing University Nanjing, China.
Qin
Q
Shen
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Wencai
W
Li
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Gannan
G
Wang
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Yihui
Y
Ma
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Jingjing
J
Xu
Department of Pathology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China ; Basic Medicine College of Zhengzhou University China.
Zhihua
Z
Zhao
D000328:Adult; D000368:Aged; D000798:Angiomatosis / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012598:Sclerosis; D013154:Spleen / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D013156:Splenectomy; D013158:Splenic Diseases / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D015854:Up-Regulation
D015415:Biomarkers; D017730:Ki-1 Antigen
CD30; EBER; Spleen; differential diagnosis; sclerosing angiomatoid nodular transformation