Comparison of Ganglion Cell and Retinal Nerve Fiber Layer Thickness in Pigment Dispersion Syndrome, Pigmentary Glaucoma, and Healthy Subjects with Spectral-domain OCT.
OBJECTIVE
To evaluate the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) thickness in pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) with RTVue spectral domain optical coherence tomography (SD-OCT).


METHODS
A total of 102 subjects were enrolled: 29 with PDS, 18 with PG, and 55 normal subjects. Full ophthalmic examination including visual field analysis was performed. SD-OCT was used to analyze GCC superior, GCC inferior, and average RNFL thickness. To compare the discrimination capabilities, the areas under the receiver operating characteristic curves were assessed.


RESULTS
Superior GCC, inferior GCC, and RNFL thickness values of patients with PG were statistically signicantly lower than those of patients with PDS (p < 0.001) and healthy individuals (p < 0.001 for all). No statistically significant difference was found between PDS and normal subjects in same parameters (p > 0.05).


CONCLUSIONS
The SD-OCT-derived GCC and RNFL thickness parameters can be useful to discriminate PG from both PDS and normal subjects.
a Kayseri Education and Research Hospital, Department of Ophthalmology , Kayseri , Turkey.
Hasan Basri
HB
Arifoglu
b Pamukkale University, School of Medicine, Department of Ophthalmology , Denizli , Turkey.
Huseyin
H
Simavli
c Ankara Training and Education Hospital, Ophthalmology Department , Ankara , Turkey.
Inci
I
Midillioglu
d Ankara Atatürk Training and Research Hospital , Ankara , Turkey , and.
Sule
S
Berk Ergun
e Maltepe University School of Medicine, Department of Ophthalmology , Istanbul , Turkey.
Saban
S
Simsek
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*
Ganglion cell layer; optical coherence tomography; pigment dispersion; pigmentary glaucoma; retinal nerve fiber layer