Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study.
Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. 192 consecutive participants ≥65 years, recruited in the cross-sectional CLIP (Cognition and LIPophilic vitamins) study, were separated into two groups according to the tertiles of dietary phylloquinone intake (i.e., lowest third below 207 µg/day versus the other two thirds combined). Daily dietary phylloquinone intake was estimated from 50-item interviewer-administered food frequency questionnaire. Cognition was assessed with Mini-Mental State Examination (MMSE); behaviour with Frontotemporal Behavioral Rating Scale (FBRS). Age, gender, social problems, education, body mass index (BMI), comorbidities, history of stroke, use vitamin K antagonists, inadequate fatty fish intake, serum thyroid-stimulating hormone (TSH), vitamin B12, albumin, and estimated glomerular filtration rate were used as confounders. Compared to participants in the lowest third of dietary phylloquinone intake (n = 64), those with higher intake had higher (i.e., better) mean MMSE score (22.0 ± 5.7 versus 19.9 ± 6.2, p = 0.024) and lower (i.e., better) FBRS score (1.5 ± 1.2 versus 1.9 ± 1.3, p = 0.042). In multivariate linear regressions, log dietary phylloquinone intake was positively associated with MMSE score (adjusted β = 1.66, p = 0.013) and inversely associated with FBRS score (adjusted β = -0.33, p = 0.037). Specifically, log dietary phylloquinone intake correlated negatively with FBRS subscore of physical neglect (r = -0.24, p = 0.001). Higher dietary phylloquinone intake was associated with better cognition and behavior among older adults.
Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers F-49933, France. justine.chouet@gmail.com.
Justine
J
Chouet
Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada. guylaine.ferland@umontreal.ca.
Guylaine
G
Ferland
Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France. catherine.feart@isped.u-bordeaux2.fr.|INSERM, ISPED, INSERM_U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France. catherine.feart@isped.u-bordeaux2.fr.
Catherine
C
Féart
Department of Geriatric Medicine, Institut du Vieillissement, University Hospital INSERM U1027, Toulouse F-31400, France. rolland.y@chu-toulouse.fr.
Yves
Y
Rolland
Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada. nancy.presse@umontreal.ca.
Nancy
N
Presse
Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada. kariane.boucher@gmail.com.
Kariane
K
Boucher
Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France.|INSERM, ISPED, INSERM_U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France.
Pascale
P
Barberger-Gateau
Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers F-49933, France. OlBeauchet@chu-angers.fr.
Olivier
O
Beauchet
Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers F-49933, France. CeAnnweiler@chu-angers.fr.|Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON N6A 5B7, Canada. CeAnnweiler@chu-angers.fr.
Cedric
C
Annweiler
D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003071:Cognition / Q000187:drug effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D011795:Surveys and Questionnaires; D014812:Vitamin K / Q000008:administration & dosage*; D010837:Vitamin K 1 / Q000008:administration & dosage*
D014812:Vitamin K; D010837:Vitamin K 1
behavior; cognition; diet; older adults; vitamin K