A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique.
This study presents a MLC-based, 3D grid-therapy technique with characteristics of both 3D-conformal-radiotherapy and grid-therapy. It generates a brachytherapy-like dose distribution, with D50% of 20, 9.8, 5.4 and 2.9-Gy, for the spheres, target, 1 cm-outershell and 2 cm-outershell, respectively. It may provide a strategy to deliver ablative doses to large tumors safely.
Radiation Oncology, Georgia Regents University, Augusta, United States. Electronic address: jjin@gru.edu.
Jian-Yue
JY
Jin
Radiation Oncology, Henry Ford Hospital, Detroit, United States.
Bo
B
Zhao
Radiation Oncology, Georgia Regents University, Augusta, United States.
Joseph M
JM
Kaminski
Radiation Oncology, Henry Ford Hospital, Detroit, United States.
Ning
N
Wen
Radiation Oncology, Henry Ford Hospital, Detroit, United States.
Yimei
Y
Huang
Neurosurgery, Georgia Regents University, Augusta, United States.
John
J
Vender
Radiation Oncology, Henry Ford Hospital, Detroit, United States.
Indrin J
IJ
Chetty
Radiation Oncology, Georgia Regents University, Augusta, United States.
Feng-Ming Spring
FM
Kong
D019583:Dose Fractionation, Radiation; D006801:Humans; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D020266:Radiotherapy, Conformal / Q000379:methods*
Ablative radiation; Film dosimetry; Grid therapy; Immune-response; Spatially fractionated radiotherapy