[Soft tissue regeneration after implantation of two novel citric acid-based biodegradable materials in rats].
OBJECTIVE
To observe the soft tissue regeneration after implantation of two novel citric acid-based biodegradable materials in the skull defects in rats.


METHODS
Two novel citric acid-based biodegradable materials were implanted in the muscular tissues in the thigh and harvested 2 weeks later. Another 40 rats with surgically induced cranial defect were randomized into control group, autograft group, CUPE-HA group, and POC-HA group (n=10), and 3 months after implantation, the materials were harvested for histological and morphometric analyses.


RESULTS
Soft tissue regeneration was stimulated by the two biodegradable materials in the muscular tissues. The implants also stimulated angiogenesis and soft tissue regeneration in the cranial defect and accelerated of intramembranous ossification.


CONCLUSIONS
The 2 novel citric acid-based biodegradable materials can induce angiogenesis and soft tissue regeneration and accelerate intramembranous ossification in rats with cranial defects.
Department of Hand and Foot Surgery, Central Hospital of Shengli Oil Field, Dongying 257034, China. E-mail: shanlianliang@yeah.net.
Lianliang
L
Shan
Tingjun
T
Tao
Yuhui
Y
Chen
Dong
D
Huang
Weichi
W
Wu
Xiaochun
X
Bai
Dawei
D
Sun
D020341:Absorbable Implants; D000818:Animals; D019343:Citric Acid; D018919:Neovascularization, Physiologic; D010012:Osteogenesis; D051381:Rats; D012038:Regeneration; D012886:Skull; D017695:Soft Tissue Injuries / Q000628:therapy*; D014945:Wound Healing
D019343:Citric Acid