Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy.
OBJECTIVE
To evaluate the feasibility of wide-field Megahertz (MHz) OCT imaging in patients with diabetic retinopathy.


METHODS
A consecutive series of 15 eyes of 15 patients with diagnosed diabetic retinopathy were included. All patients underwent Megahertz OCT imaging, a close clinical examination, slit lamp biomicroscopy, and funduscopic evaluation. To acquire densely sampled, wide-field volumetric datasets, an ophthalmic 1050 nm OCT prototype system based on a Fourier-domain mode-locked (FDML) laser source with 1.68 MHz A-scan rate was employed. RESULTS. We were able to obtain OCT volume scans from all included 15 patients. Acquisition time was 1.8 seconds. Obtained volume datasets consisted of 2088 × 1044 A-scans of 60° of view. Thus, reconstructed en face images had a resolution of 34.8 pixels per degree in x-axis and 17.4 pixels per degree. Due to the densely sampled OCT volume dataset, postprocessed customized cross-sectional B-frames through pathologic changes such as an individual microaneurysm or a retinal neovascularization could be imaged.


CONCLUSIONS
Wide-field Megahertz OCT is feasible to successfully image patients with diabetic retinopathy at high scanning rates and a wide angle of view, providing information in all three axes. The Megahertz OCT is a useful tool to screen diabetic patients for diabetic retinopathy.
Department of Ophthalmology, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany.
Lukas
L
Reznicek
Institute for Biomolecular Optics, Ludwig Maximilians University, Oettingenstrasse 67, 80538 Munich, Germany ; Institute of Biomedical Optics, University of Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Jan P
JP
Kolb
Institute for Biomolecular Optics, Ludwig Maximilians University, Oettingenstrasse 67, 80538 Munich, Germany.
Thomas
T
Klein
Institute for Biomolecular Optics, Ludwig Maximilians University, Oettingenstrasse 67, 80538 Munich, Germany.
Kathrin J
KJ
Mohler
Institute for Biomolecular Optics, Ludwig Maximilians University, Oettingenstrasse 67, 80538 Munich, Germany.
Wolfgang
W
Wieser
Institute of Biomedical Optics, University of Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Robert
R
Huber
Department of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, Germany.
Marcus
M
Kernt
Department of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, Germany.
Josef
J
Märtz
Department of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, Germany.
Aljoscha S
AS
Neubauer
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019412:Anatomy, Cross-Sectional; D016477:Artifacts; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005583:Fourier Analysis; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*