PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?
In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA. Electronic address: atoker@bidmc.harvard.edu.
Alex
A
Toker
Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA. Electronic address: rameh@bu.edu.
Lucia
L
Rameh
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D006801:Humans; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*
D051057:Proto-Oncogene Proteins c-akt; D010744:Phosphoric Monoester Hydrolases