Novel imaging approaches in adult asthma and their clinical potential.
Currently, imaging in asthma is confined to chest radiography and CT. The emergence of new imaging techniques and tremendous improvement of existing imaging methods, primarily due to technological advancement, has completely changed its research and clinical prospects. In research, imaging in asthma is now being employed to provide quantitative assessment of morphology, function and pathogenic processes at the molecular level. The unique ability of imaging for non-invasive, repeated, quantitative, and in vivo assessment of structure and function in asthma could lead to identification of 'imaging biomarkers' with potential as outcome measures in future clinical trials. Emerging imaging techniques and their utility in the research and clinical setting is discussed in this review.
a 1 Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, LE3 9QP, UK.
Ruth
R
Hartley
a 1 Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, LE3 9QP, UK.
Simonetta
S
Baldi
a 1 Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, LE3 9QP, UK.
Chris
C
Brightling
a 1 Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, LE3 9QP, UK.|b 2 Radiology Department, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, LE3 9QP, UK.
Sumit
S
Gupta
D000328:Adult; D000818:Animals; D001249:Asthma / Q000175:diagnosis*; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
D015415:Biomarkers
asthma; endobronchial ultrasound; hyperpolarized MRI; molecular imaging; optical coherence tomography; positron emission tomography; quantitative computed tomography