Biomimetic particles as therapeutics.
In recent years, there have been major advances in the development of novel nanoparticle- and microparticle-based therapeutics. An emerging paradigm is the incorporation of biomimetic features into these synthetic therapeutic constructs to enable them to better interface with biological systems. Through the control of size, shape, and material consistency, particle cores have been generated that better mimic natural cells and viruses. In addition, there have been significant advances in biomimetic surface functionalization of particles through the integration of bio-inspired artificial cell membranes and naturally derived cell membranes. Biomimetic technologies enable therapeutic particles to have increased potency to benefit human health.
Department of Biomedical Engineering, Translational Tissue Engineering Center, and Institute for Nanobiotechnology, Johns Hopkins School of Medicine, 400 N Broadway, Smith 5017, Baltimore MD, 21231, USA.
Randall A
RA
Meyer
Department of Biomedical Engineering, Translational Tissue Engineering Center, and Institute for Nanobiotechnology, Johns Hopkins School of Medicine, 400 N Broadway, Smith 5017, Baltimore MD, 21231, USA.
Joel C
JC
Sunshine
Department of Biomedical Engineering, Translational Tissue Engineering Center, and Institute for Nanobiotechnology, Johns Hopkins School of Medicine, 400 N Broadway, Smith 5017, Baltimore MD, 21231, USA.|Departments of Materials Science and Engineering, Oncology, Ophthalmology, and Neurosurgery, Johns Hopkins School of Medicine, 400 N Broadway, Smith 5017, Baltimore MD, 21231, USA.
Jordan J
JJ
Green
D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry / Q000627:therapeutic use*; D032701:Biomimetics; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D036103:Nanotechnology
biomaterial; biomimetic; drug delivery; micro/nanoparticle