Intraepidermal benign sebaceous neoplasm: apocrine poroma (hidroacanthoma simplex type) with extensive sebaceous differentiation with sebaceoma-like features.
We herein report a patient who clinically presented with a yellowish, flat plaque that histopathologically showed a benign lesion mainly composed of intraepidermal basaloid nests with sebaceous differentiation. This lesion was considered to be fundamentally apocrine poroma (hidroacanthoma simplex type) with sebaceous differentiation. Nests composed of typical poroid cells were seen, and the results of immunostaining for lumican supported this diagnosis and excluded the possibility of clonal seborrheic keratosis. The sebaceous differentiation in apocrine poromas mostly occurs in Pinkus type lesions, and is usually seen in only part of the lesions, as solitary, mature sebocytes within the poroma nests. However, our apocrine poroma case was unique not only in that sebaceous differentiation occurred in the hidroacanthoma simplex type, but also in that it was observed extensively (approximately 60% of the nests). We therefore called this lesion an 'intraepidermal benign sebaceous neoplasm'. Although it may be hard to differentiate sebaceous germinative cells (seen in sebaceoma) from poroid cells, in this case, some poroma nests could be judged to neighbor or contain the sebaceoma-like areas. Therefore, the presented apocrine poroma was considered to have some features of (intraepidermal and dermal) sebaceoma.
Division of Dermatology, Nakao Clinic, Saga, Japan.
Noriyuki
N
Misago
Division of Dermatology, Department of Internal Medicine, Saga University, Saga, Japan.
Takuya
T
Inoue
Department of Pathology, Faculty of Medicine, Saga University, Saga, Japan.
Shuji
S
Toda
D000328:Adult; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D057091:Poroma / Q000378:metabolism / Q000473:pathology; D012626:Sebaceous Gland Neoplasms / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
apocrine poroma with sebaceous differentiation; clonal seborrheic keratosis; hidroacanthoma simplex; lumican; sebaceoma