Spectrum of IgG4-related disease on multi-detector CT: a 5-year study of a single medical center data.
OBJECTIVE
To discuss the diverse imaging features of pancreatic and extra-pancreatic lesions of IgG4-related disease (IgG4-RD) on multi-detector CT (MDCT).


METHODS
This retrospective study was approved by our institutional research ethics board, and informed consent was waived. From 2008 to 2013, 159 patients including 120 men (mean age 57 years; range 27-79 years) and 39 women (mean age 51 years; range 25-83 years) who met the comprehensive diagnostic criteria for IgG4-RD (2011) were enrolled. MDCT images consisted of 153 abdominal images, 64 pelvic images, 64 thoracic images, and 8 neck images were retrospectively analyzed in consensus by two radiologists with expertise in the CT diagnosis of IgG4-RD.


RESULTS
Only 11 (11/153, 7.2%) IgG4-RD patients had been found with no pancreatic involvement. 145 (145/159, 91.2%) patients had various extra-pancreatic lesions, including involvement of biliary tree (93/153, 60.8%), peri-pancreatic vessels (66/153, 43.1%), IgG4-related lymphadenopathy, peri-abdominal aorta arteritis or retroperitoneal fibrosis, head and neck lesions, etc. Renal lesions were found in 26 (26/153, 17.0%) IgG4-RD patients with 4 types of renal parenchymal involvement. Lung lesions were found in 44 (44/64, 68.7%) IgG4-RD patients, which were classified into 7 types.


CONCLUSIONS
Pancreatic and various extra-pancreatic lesions may be involved in IgG4-RD patients frequently with typical imaging findings. It is useful to recognize the atypical or uncommon imaging features to help the diagnosis of IgG4-RD together with other serologic or histopathologic findings.
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., Beijing, 100730, People's Republic of China.
Yonglan
Y
He
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., Beijing, 100730, People's Republic of China.
Xuechao
X
Du
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., Beijing, 100730, People's Republic of China.
Ning
N
Ding
Amcare Clinic, Beijing, People's Republic of China.
Zhuo
Z
Li
Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Weixun
W
Zhou
Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Bo
B
Chen
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., Beijing, 100730, People's Republic of China.
Zhengyu
Z
Jin
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., Beijing, 100730, People's Republic of China.
Hao
H
Sun
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., Beijing, 100730, People's Republic of China.
Liang
L
Zhu
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., Beijing, 100730, People's Republic of China. huadanx@163.com.
Huadan
H
Xue
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D009333:Neck / Q000000981:diagnostic imaging; D010179:Pancreas / Q000000981:diagnostic imaging; D010388:Pelvis / Q000000981:diagnostic imaging; D011860:Radiography, Abdominal; D013902:Radiography, Thoracic; D012189:Retrospective Studies
D007074:Immunoglobulin G
Extra-pancreatic lesions; IgG4-related disease; Multi-detector CT; Pancreatic lesions