The dynamic control of signal transduction networks in cancer cells.
Cancer is often considered a genetic disease. However, much of the enormous plasticity of cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and to withstand therapeutic assaults is encoded by the structure and spatiotemporal dynamics of signal transduction networks. In this Review, we discuss recent concepts concerning how the rich signalling dynamics afforded by these networks are regulated and how they impinge on cancer cell proliferation, survival, invasiveness and drug resistance. Understanding this dynamic circuitry by mathematical modelling could pave the way to new therapeutic approaches and personalized treatments.
Systems Biology Ireland, University College Dublin.|Conway Institute of Biomolecular &Biomedical Research, University College Dublin.|School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
Walter
W
Kolch
Systems Biology Ireland, University College Dublin.
Melinda
M
Halasz
Roche Moscow Limited, Business Center Neglinnaya Plaza, Building 2, Trubnaya Square, 107031 Moscow, Russia.
Marina
M
Granovskaya
Systems Biology Ireland, University College Dublin.|Conway Institute of Biomolecular &Biomedical Research, University College Dublin.|School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
Boris N
BN
Kholodenko
D049109:Cell Proliferation; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction