Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues.
We report the production, isolation, and characterization of jadomycins with seven-, nine-, and ten-membered E-rings, all of which are unique natural product ring scaffolds. This significantly expands the scope of a non-enzymatic biosynthetic step in jadomycin biosynthesis in order to produce novel natural products.
Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Camilo F
CF
Martinez-Farina
David L
DL
Jakeman
D002851:Chromatography, High Pressure Liquid; D007546:Isoquinolines / Q000737:chemistry*; D009285:Naphthoquinones / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D053719:Tandem Mass Spectrometry
D007546:Isoquinolines; D009285:Naphthoquinones; C506597:jadomycin A; C081750:jadomycin B