Homeostasis of Hemostasis: The Role of Endothelium.
Forming an interface with virtually every other organ, endothelium has a strategic role in modulating vascular homeostasis. While its miscellany of functions includes regulation of vasomotor tone, promotion, and prevention of vascular growth, and modulation of inflammatory and hemostatic processes, it functions critically in maintaining the balance of hemostasis in health. Whereas endothelium has been recognized to influence all stages of hemostasis, new evidence suggests it to have a primary role for thrombin generation. Endothelial dysfunction is being increasingly appreciated in several pathological states and particularly, by virtue of its critical role in hemostasis, in causing thrombosis in a multitude of diseases.
Departmental of Haematology, University Hospital Southampton, Southampton, United Kingdom.
Rashid S
RS
Kazmi
Departmental of Haematology, University Hospital Southampton, Southampton, United Kingdom.
Sara
S
Boyce
Faculty of Health Sciences, University of Southampton, Southampton, United Kingdom.
Bashir A
BA
Lwaleed
D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D042783:Endothelial Cells / Q000473:pathology / Q000502:physiology; D000074283:Endothelial Protein C Receptor; D004730:Endothelium, Vascular / Q000473:pathology / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000502:physiology; D019899:Paracrine Communication; D011956:Receptors, Cell Surface / Q000502:physiology; D013917:Thrombin / Q000096:biosynthesis; D018180:Thrombomodulin / Q000502:physiology; D019851:Thrombophilia / Q000097:blood / Q000209:etiology / Q000473:pathology; D013925:Thromboplastin / Q000502:physiology; D013927:Thrombosis / Q000097:blood* / Q000209:etiology / Q000473:pathology; D014841:von Willebrand Factor / Q000502:physiology
D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; D006728:Hormones; D008074:Lipoproteins; C478370:PROCR protein, human; D011956:Receptors, Cell Surface; D018180:Thrombomodulin; C051928:lipoprotein-associated coagulation inhibitor; D014841:von Willebrand Factor; D013925:Thromboplastin; D013917:Thrombin