[Late morphological teeth changes in children after chemotherapy].
BACKGROUND
Teeth changes after chemotherapy are of clinical importance, but no morphological studies were conducted on microscopic level.


OBJECTIVE
To assess morphological changes in teeth developing under chemotherapy.


METHODS
Twenty-nine adolescents aged 13-16 years that received chemotherapy at the age of 2-13 were included in the study. Teeth morphology was evaluated by means of clinical and radiological data as well as microscopy of extracted teeth (n=13). Thirty healthy children aged 13-16 and 8 teeth extracted for orthodontic reasons served as a control.


RESULTS
Chemotherapy has arresting impact on teeth development confirmed by aplasia of germs when influenced on stages I-II (p=0.0001), preliminary apexogenesis resulting in shortened roots in teeth at the later stages of growth and development (p=0.01). Enamel and dentine defects usually located in cervical area are also a specific feature, while caries incidence was not higher when compared to control group.


CONCLUSIONS
Children receiving chemotherapy have high risk of secondary teeth loss because of germs aplasia and extraction of severely decayed teeth. Early diagnostics helps to prevent secondary deformations of dental arches by prompt prosthetic rehabilitation. Root morphology changes should be considered by root canal treatment.
Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
M V
MV
Korolenkova
D000293:Adolescent; D000848:Anodontia / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D024221:Antineoplastic Protocols; D003743:Dental Enamel / Q000002:abnormalities; D003804:Dentin / Q000002:abnormalities; D019229:Dentition, Permanent; D005260:Female; D006801:Humans; D008297:Male; D012306:Risk; D012390:Root Canal Therapy; D014070:Tooth / Q000187:drug effects* / Q000254:growth & development / Q000473:pathology*; D014071:Tooth Abnormalities / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D014092:Tooth Root / Q000002:abnormalities / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents