Serum anti-p53 antibody as a tumour marker for colorectal cancer screening.
A 60-year-old Japanese man presented to our hospital for further investigation of an elevated serum anti-p53 antibody level. He was diagnosed with colon cancer and the tumour was surgically resected. Histological diagnosis of advanced colon cancer without lymph node involvement or distant metastasis was made. It was noteworthy that both serum carcinoembryonic antigen (CEA) and a fecal occult blood test that were performed preoperatively were non-diagnostic. This case highlights the potential usefulness of serum anti-p53 antibody tests for detection of colorectal cancers. Moreover, sequential changes in the anti-p53 antibody levels after curative resection were observed.
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan ; Department of Gastroenterology, Onomichi Municipal Hospital, 722-8503, Onomichi, Japan.
Masaya
M
Iwamuro
Department of Gastroenterology, Onomichi Municipal Hospital, 722-8503, Onomichi, Japan.
Yoshinari
Y
Kawai
Department of Surgery, Onomichi Municipal Hospital, 722-8503, Onomichi, Japan.
Tomoko
T
Matsumoto
Department of Surgery, Onomichi Municipal Hospital, 722-8503, Onomichi, Japan.
Masashi
M
Uda
Department of Endoscopy, Okayama University Hospital, Okayama 700-8558, Japan.
Hiroyuki
H
Okada
anti-p53 antibody; cancer screening tests; colon cancers; colorectal carcinoma; early diagnosis of cancer