Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells.
Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at 100 ppm than the negatively charged 3-mercaptopropionic acid (MPA) functionalized ones which caused 30% cell death. The results show through surface functionalization Pd nanosheets can be modified to interact differently with HepG2 cancerous cells, resulting in varied cytotoxicity.
University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering, 206 Roger Adams Lab, Box C-3, MC-712, 600 South Methews Avenue, Urbana, IL 61801 (USA).
Yung-Tin
YT
Pan
University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering, 206 Roger Adams Lab, Box C-3, MC-712, 600 South Methews Avenue, Urbana, IL 61801 (USA).
Cartney E
CE
Smith
University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering, 206 Roger Adams Lab, Box C-3, MC-712, 600 South Methews Avenue, Urbana, IL 61801 (USA).
Kam Sang
KS
Kwok
University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering, 206 Roger Adams Lab, Box C-3, MC-712, 600 South Methews Avenue, Urbana, IL 61801 (USA).
Jinrong
J
Chen
University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering, 206 Roger Adams Lab, Box C-3, MC-712, 600 South Methews Avenue, Urbana, IL 61801 (USA).
Hyunjoon
H
Kong
University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering, 206 Roger Adams Lab, Box C-3, MC-712, 600 South Methews Avenue, Urbana, IL 61801 (USA).
Hong
H
Yang
D000588:Amines / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology*; D010316:Particle Size; D055672:Static Electricity; D013329:Structure-Activity Relationship; D013499:Surface Properties
D000588:Amines; D002264:Carboxylic Acids; D009942:Organometallic Compounds; D010165:Palladium