Evaluation of Selective Arterial Embolization Effect by Chitosan Micro-Hydrogels in Hindlimb Sarcoma Rodent Models Using Various Imaging Modalities.
OBJECTIVE
Embolization is mainly used to reduce the size of locally advanced tumors. In this study, selective arterial catheterization with chitosan micro-hydrogels (CMH) into the femoral artery was performed and the therapeutic effect was validated using different imaging methods.


METHODS
Male SD rats (n = 18, 6 weeks old) were randomly assigned into three groups: Group 1 as control, Group 2 without any ligation of distal femoral artery, and Group 3 with temporary ligation of the distal femoral artery. RR1022 sarcoma cell lines were inoculated into thigh muscle. After 1 week, CMH was injected into the proximal femoral artery. Different imaging modalities were performed during a 3-week follow-up.


RESULTS
The tumor size was significantly (P < 0.001) decreased in both Group 2 and Group 3 (P < 0.001) after selective arterial embolization therapy. (18)F-FDG-PET/CT revealed decreased intensity of (18)F-FDG uptake in tumors. The accumulation status of (125)I-CMH near the tumor was verified by gamma camera.


CONCLUSIONS
Appropriate selective arterial embolization therapy with CMH was.
Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Tai Kyoung
TK
Lee
Kai Bio Tech, Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
JeongIl
J
Kwon
Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Kyung Sook
KS
Na
Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Hwan-Seok
HS
Jeong
Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Hyosook
H
Hwang
Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Phil-Sun
PS
Oh
Kai Bio Tech, Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Dong Hyun
DH
Kim
Department of Pathology, Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Kyu Yun
KY
Jang
Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Seok Tae
ST
Lim
Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Myung-Hee
MH
Sohn
Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea ; Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Geonji-ro, Dukjin-gu, Jeonju, Republic of Korea.
Hwan-Jeong
HJ
Jeong
Chitosan micro-hydrogel; Gamma camera; Molecular imaging; Positron emission tomography (PET); RR1022; Rodent; Sarcoma; Selective arterial embolization; Ultrasonography