Relationship of serum 25-Hydroxyvitamin D (25[OH]D) levels and components of metabolic syndrome in prepubertal children.
OBJECTIVE
The relationship between 25-hydroxyvitamin D (25[OH]D) levels and the lipid and metabolic levels of the prepubertal normal population is unclear. Our goals were to investigate the association of serum 25(OH)D concentrations with lipid and metabolic levels in Korean prepubertal children ages 7-9 y.


METHODS
We followed 205 children, ages 7-9 y in the Ewha Birth and Growth Cohort study, a prospective cohort sample established in 2001-2006, from July to August 2011. We studied the association of serum 25-hydroxyvitamin D (25[OH]D) levels with components of metabolic syndrome and insulin resistance indices using multivariate regression analysis adjusted for body mass index (BMI) z-scores.


RESULTS
The mean age of the 205 subjects was 7.89 ± 0.85 y, and the sample included 109 boys (53.2%). The average 25(OH)D levels of all participants was 25.0 ± 5.4 ng/mL. After adjustment for age and sex, triacylglycerol levels were significantly associated with 25(OH)D (β = -0.02, P = 0.02) concentrations even after adjustment for BMI z-scores (β = -0.02, P = 0.04). However, other metabolic components were not correlated with 25(OH)D status. Those with the lowest quartile of 25(OH)D levels had the highest serum triacylglycerol levels (P = 0.04, Ptrend = 0.01).


CONCLUSIONS
We found that serum 25(OH)D levels were negatively associated with serum triacylglycerol levels, even independently of adiposity, in prepubertal children. This study suggests that 25(OH)D insufficiency is related to metabolic syndrome via the derangement of triacylglycerol metabolism.
Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.
Jung Hyun
JH
Kwon
Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.
Seung Eun
SE
Lee
Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea.
Hye Ah
HA
Lee
Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Korea.
Young Ju
YJ
Kim
Department of Anatomy, School of Medicine, Ewha Womans University, Seoul, Korea.
Hwa Young
HY
Lee
College of Pharmacy, Ewha Womans University, Seoul, Korea.
Hye Sun
HS
Gwak
Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.
Eun Ae
EA
Park
Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.
Su Jin
SJ
Cho
Department of Food and Nutrition, Kyung Hee University, Seoul, Korea.
Se Young
SY
Oh
Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea.
Eun Hee
EH
Ha
Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea. Electronic address: hpark@ewha.ac.kr.
Hyesook
H
Park
Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea. Electronic address: hyesk@ewha.ac.kr.
Hae Soon
HS
Kim
D050154:Adiposity; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology*; D009765:Obesity / Q000097:blood / Q000150:complications; D011446:Prospective Studies; D056910:Republic of Korea; D014280:Triglycerides / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*
D014280:Triglycerides; D014807:Vitamin D; C104450:25-hydroxyvitamin D
Children; Dyslipidemia; Vitamin D