Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza).
Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. xiangxiyi81@aliyun.com.
Xiang-Xi
XX
Yi
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. dengjg53@126.com.
Jia-Gang
JG
Deng
Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China. gaochenghai@gxas.cn.
Cheng-Hai
CH
Gao
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. xthou@126.com.
Xiao-Tao
XT
Hou
Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China. finylee@yeah.net.
Fei
F
Li
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. wangzhiping@163.com.
Zhi-Ping
ZP
Wang
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. ewhao@163.com.
Er-Wei
EW
Hao
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. xiey2009@126.com.
Yan
Y
Xie
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. duzhengcai8@163.com.
Zheng-Cai
ZC
Du
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. hhx123@hotmail.com.
Hui-Xue
HX
Huang
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. huangriming@scib.ac.cn.|Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. huangriming@scib.ac.cn.
Ri-Ming
RM
Huang
D000097:Acetonitriles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D018546:Hypocotyl / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D043982:Rhizophoraceae / Q000737:chemistry*; D053833:Wetlands
D000097:Acetonitriles; D001572:Benzofurans; D006027:Glycosides; D010936:Plant Extracts; C438745:menisdaurilide; C504636:menisdaurin
Bruguiera gymnorrhiza; antiviral; cyclohexylideneacetonitrile derivative