Propranolol Decreases Proliferation of Endothelial Cells Transformed by Kaposi's Sarcoma-Associated Herpesvirus and Induces Lytic Viral Gene Expression.
Kaposi's sarcoma (KS) is common in Africa, but economic constraints hinder successful treatment in most patients. Propranolol, a generic β-adrenergic antagonist, decreased proliferation of KS-associated herpesvirus (KSHV)-infected cells. Downregulation of cyclin A2 and cyclin-dependent kinase 1 (CDK1) recapitulated this phenotype. Additionally, propranolol induced lytic gene expression in association with downregulation of CDK6. Thus, propranolol has diverse effects on KSHV-infected cells, and this generic drug has potential as a therapeutic agent for KS.
Division of Pediatric Infectious Diseases, University of Minnesota Medical School, and Center for Infectious Diseases and Microbiology Translational Research, Minneapolis, Minnesota, USA smcallis@umn.edu.
Shane C
SC
McAllister
Division of Pediatric Infectious Diseases, University of Minnesota Medical School, and Center for Infectious Diseases and Microbiology Translational Research, Minneapolis, Minnesota, USA.
Ryan S
RS
Hanson
Division of Pediatric Infectious Diseases, University of Minnesota Medical School, and Center for Infectious Diseases and Microbiology Translational Research, Minneapolis, Minnesota, USA.
Rory D
RD
Manion
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D016203:CDC2 Protein Kinase; D049109:Cell Proliferation / Q000187:drug effects*; D056751:Cyclin A2 / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D042783:Endothelial Cells / Q000187:drug effects / Q000821:virology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D019288:Herpesvirus 8, Human / Q000378:metabolism*; D006801:Humans; D011433:Propranolol / Q000494:pharmacology*; D012514:Sarcoma, Kaposi / Q000188:drug therapy*
D000319:Adrenergic beta-Antagonists; C503721:CCNA2 protein, human; D056751:Cyclin A2; D011433:Propranolol; D016203:CDC2 Protein Kinase; C528899:CDK1 protein, human; D018844:Cyclin-Dependent Kinases