Diagnostics and Discovery in Viral Central Nervous System Infections.
The range of viruses implicated in central nervous system disease continues to grow with globalization of travel and trade, emergence and reemergence of zoonoses and investments in discovery science. Diagnosis of viral central nervous system infections is challenging in that brain tissue, where the pathogen concentration is likely to be highest, is not readily obtained and sensitive methods for molecular and serological detection of infection are not available in most clinical microbiology laboratories. Here we review these challenges and discuss how they may be addressed using advances in molecular, proteomic and immunological methods.
Center for Infection and Immunity, Columbia University, New York, NY.
Walter Ian
WI
Lipkin
Center for Infection and Immunity, Columbia University, New York, NY.
Mady
M
Hornig
D000818:Animals; D001921:Brain / Q000821:virology*; D020805:Central Nervous System Viral Diseases / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D016133:Polymerase Chain Reaction; D040901:Proteomics; D012698:Serologic Tests
CNS infection; viral encephalitis