Effects of penicillin and erythromycin on adherence of invasive and noninvasive isolates of Streptococcus pyogenes to laminin.
This study investigated the possible relationship between the invasiveness of group A Streptococcus (GAS) strains and their abilities to adhere to laminin and assessed the effects of subinhibitory concentrations of penicillin and erythromycin on the ability of GAS to adhere to laminin. The adherence of noninvasive and highly invasive isolates of GAS to laminin was significantly higher than the adherence displayed by isolates of low invasiveness. Antibiotic treatment caused significant reductions in adherence to laminin in all three groups of strains. Penicillin was more successful in reducing the adherence abilities of the tested GAS strains than erythromycin.
Department of Microbiology and Immunology, Faculty of Medicine, University of Banja Luka, Banja Luka, Republic of Srpska, BA.
Aleksandra
A
Šmitran
Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, RS.
Dragana
D
Vuković
Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, RS.
Ina
I
Gajić
Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, RS.
Jelena
J
Marinković
Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, RS.
Lazar
L
Ranin
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007797:Laminin / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D007797:Laminin; D010406:Penicillins; D004917:Erythromycin