NHC-catalyzed activation of α,β-unsaturated N-acyltriazoles: an easy access to dihydropyranones.
An N-heterocyclic carbene catalyzed activation of α,β-unsaturated N-acyltriazoles is described. The in situ generated α,β-unsaturated acylazolium intermediates allowed an enantioselective formal [3+3] cycloaddition with 1,3-dicarbonyl compounds. The resulting dihydropyranones are formed in good to excellent yields and with high enantioselectivities.
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany. enders@rwth-aachen.de.
Qijian
Q
Ni
Jiawen
J
Xiong
Xiaoxiao
X
Song
Gerhard
G
Raabe
Dieter
D
Enders