[Geographical distribution of MTHFR and MTRR gene polymorphisms among the Han women in Zhengzhou city].
OBJECTIVE
To explore the genotype distribution of 5,10-methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) among Chinese Han women in Zhengzhou.


METHODS
A total of 1 253 women were recruited from Zhengzhou city. The genotype of MTHFR C677T, A1298C and MTRR A66G was detected to analyze the distribution of gene polymorphisms and to compare them with the published data from other Han women.


RESULTS
The frequency of the MTHFR 1298CC genotypes (1.3%) in Zhengzhou was lower than that in Xiangtan (4.8%), Yanbian (3.8%), Zhenjiang (3.5%), Jingzhou (3.2%), Kunming (2.7%), Deyang (6.3%), Huizhou (7.2%) and Wulumuqi (3.4%) (all P<0.05). The difference in allele frequency was significant compared with that in Yantai, Yanbian, Wulumuqi, Zhenjiang, Jingzhou, Kunming, Dezhou, Xiangtan or Huizhou (all P<0.05). The frequency of the MTRR 66GG genotypes (5.4%) in Zhengzhou was lower than that in Deyang (8.2%) (P<0.01) and allele frequency between them was significant difference (P<0.05).


CONCLUSIONS
The gene polymorphism of MTHFR A1298C and MTRR A66G among the Han women in Zhengzhou is statistically different from that in some regions of China.
Department of Laboratory Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.
Huiling
H
Cui
Institute of Targeted Therapy and Molecular Medicine of Shanghai, Shanghai 200433, China.
Yanqiang
Y
Lu
Institute of Targeted Therapy and Molecular Medicine of Shanghai, Shanghai 200433, China.
Shaojie
S
Ma
Institute of Targeted Therapy and Molecular Medicine of Shanghai, Shanghai 200433, China.
Yan
Y
Xue
Department of Laboratory Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.
Ting
T
Wang
Department of Laboratory Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.
Gehong
G
Duan
National Center for Women and Children's Health, Chinese CDC, Beijing 100101, China.
Qi
Q
Yang
D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic
C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)