Impact of Subsequent Therapies on Outcome of the FIRE-3/AIO KRK0306 Trial: First-Line Therapy With FOLFIRI Plus Cetuximab or Bevacizumab in Patients With KRAS Wild-Type Tumors in Metastatic Colorectal Cancer.
OBJECTIVE
We investigated choice and efficacy of subsequent treatment, with special focus on second-line therapy, in the FIRE-3 trial (FOLFIRI plus cetuximab [arm A] or bevacizumab [arm B]) for patients with KRAS wild-type metastatic colorectal cancer.


METHODS
Start of subsequent-line (second or third) therapy was defined as use of an antitumor drug that was not part of the previous regimen. We evaluated choice, duration, and efficacy of subsequent therapy and determined the impact of subsequent-line treatment on outcome of patients in FIRE-3.


RESULTS
Of 592 patients in the intent-to-treat population, 414 (69.9%) received second-line and 256 (43.2%) received third-line therapy. In subsequent treatment lines, 47.1% of patients originally assigned to arm A received bevacizumab, and 52.2% originally assigned to arm B received either cetuximab or panitumumab. Oxaliplatin was subsequently used in 55.9% (arm A) and 53.2% (arm B) of patients. Second-line therapy was administered for a median duration of 5.0 versus 3.2 months (P < .001) in study arm A versus B. Progression-free (6.5 v 4.7 months; hazard ratio, 0.68; 95% CI, 0.54 to 0.85; P < .001) and overall survival (16.3 v 13.2 months; hazard ratio, 0.70; 95% CI, 0.55 to 0.88; P = .0021) from start of second-line therapy were longer in patients in arm A compared with arm B.


CONCLUSIONS
Our data suggest that the sequence of drug application might be more important than exposure to single agents. In patients with RAS wild-type tumors, first-line application of anti-epidermal growth factor receptor-directed therapy may represent a favorable condition for promoting effective subsequent therapy including antiangiogenic agents.
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Dominik P
DP
Modest
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Sebastian
S
Stintzing
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Ludwig Fischer
LF
von Weikersthal
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Thomas
T
Decker
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Alexander
A
Kiani
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Ursula
U
Vehling-Kaiser
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Salah-Eddin
SE
Al-Batran
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Tobias
T
Heintges
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Christian
C
Lerchenmüller
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Christoph
C
Kahl
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Gernot
G
Seipelt
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Frank
F
Kullmann
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Martina
M
Stauch
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Werner
W
Scheithauer
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Svantje
S
Held
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Markus
M
Möhler
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Andreas
A
Jung
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.
Thomas
T
Kirchner
Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria. volker.heinemann@med.uni-muenchen.de.
Volker
V
Heinemann
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D000068818:Cetuximab / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D053208:Kaplan-Meier Estimate; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D016896:Treatment Outcome; D018631:ras Proteins / Q000235:genetics*
C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D000068258:Bevacizumab; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins; D000068818:Cetuximab; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin