New Insights into the Roles of Nogo-A in CNS Biology and Diseases.
Nogos have become a hot topic for its well-known number Nogo-A's big role in clinical matters. It has been recognized that the expression of Nogo-A and the receptor NgR1 inhibit the neuron's growth after CNS injuries or the onset of the MS. The piling evidence supports the notion that the Nogo-A is also involved in the synaptic plasticity, which was shown to negatively regulate the strength of synaptic transmission. The occurrence of significant schizophrenia-like behavioral phenotypes in Nogo-A KO rats also added strong proof to this conclusion. This review mainly focuses on the structure of Nogo-A and its corresponding receptor-NgR1, its intra- and extra-cellular signaling, together with its major physiological functions such as regulation of migration and distribution and its related diseases like stroke, AD, ALS and so on.
Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Yun-Peng
YP
Sui
Xiao-Xi
XX
Zhang
Jun-Lin
JL
Lu
Feng
F
Sui
D000818:Animals; D030801:Animals, Genetically Modified; D002490:Central Nervous System / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000503:physiopathology*; D009185:Myelin Proteins / Q000502:physiology*; D009473:Neuronal Plasticity; D000070798:Nogo Proteins; D051381:Rats; D015398:Signal Transduction
D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603197:Rtn4 protein, rat