[THE CHARACTERISTICS OF RETINA AT THE DEVELOPMENT OF PROLIFERATIVE VITREORETINOPATHY IN RATS AFTER INTRAOCULAR INJECTION OF CONCANAVALIN A AND DISPASE].
In this article we review and discuss the advantages of two proliferative vitreoretinopathy models in rats: intravitreal injection of proteolytic enzyme dispase and proinflammatory lectin concanavalin A. For the first time we selected clear morphological criteria for the retina evaluation during the inflammatory response. We also compared the effects of the injection of dispase and concanavalin on the 7th day after the drugs administration. We conclude that different doses of dispase can be used to get a stable model of PVR on different periods after the injection procedure.
A K
AK
Erdiakov
M V
MV
Tikhonovich
E M
EM
Rzhavina
S A
SA
Gavrilova
D000818:Animals; D003208:Concanavalin A / Q000633:toxicity*; D004195:Disease Models, Animal; D010450:Endopeptidases / Q000633:toxicity*; D006801:Humans; D056965:Injections, Intraocular; D051381:Rats; D012160:Retina / Q000187:drug effects / Q000503:physiopathology*; D018630:Vitreoretinopathy, Proliferative / Q000139:chemically induced / Q000503:physiopathology*
D003208:Concanavalin A; D010450:Endopeptidases; C023139:dispase