Disappearance of Upper Urinary Tract Urothelial Carcinoma after Treatment of a Borderline Brenner Tumor: Case Report and Literature Review.
BACKGROUND
Brenner tumors are relatively rare ovarian neoplasms with very few reported cases associating these tumors and urothelial carcinomas with different characteristics and particularities.


METHODS
We report an unusual clinical case of borderline unilateral Brenner tumor of the ovary associated with a highly recurrent diffuse low-grade papillary urothelial carcinoma of the upper and lower urinary tract. The patient received a total cystectomy and resection of the Brenner tumor. Her clinical response was marked by the absence of recurrence of the urothelial carcinoma and the disappearance of an untreated tumor of the upper urinary tract. The available literature on the association between these tumors was reviewed and their histologic appearance analyzed.


CONCLUSIONS
The good prognosis of urothelial carcinoma in patients with Brenner tumors suggests different risk factors, physiopathologic features, and carcinogenesis than with typical urothelial carcinoma.
Uro-Oncology Department, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
Fouad
F
Aoun
Hampig Raphael
HR
Kourie
Nicolas
N
Sirtaine
Eric
E
Hawaux
D000368:Aged; D001948:Brenner Tumor / Q000175:diagnosis / Q000628:therapy*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D009365:Neoplasm Regression, Spontaneous; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome; D014516:Ureteral Neoplasms / Q000175:diagnosis*