Distributions of selected urinary metabolites of volatile organic compounds by age, gender, race/ethnicity, and smoking status in a representative sample of U.S. adults.
Data from National Health and Nutrition Examination Survey for the years 2011-2012 were used to evaluate variability in the observed levels of 19 urinary metabolites of 15 parent volatile organic compounds (VOCs) by age, gender, race/ethnicity, and smoking status. Smokers were found to have statistically significantly higher adjusted levels than nonsmokers for selected urinary metabolites of acrolein, acrylamide, acrylonitrile, 1,3-butadiene, carbon-disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene-styrene, propylene oxide, styrene, and xylene. Female nonsmokers were found to have lower adjusted levels of selected metabolites of acrolein, carbon-disulfide, and N,N-dimethylformamide than male nonsmokers but female smokers had higher levels of each of these metabolites than male smokers. In addition, female smokers also had higher adjusted levels of selected metabolites of 1,3-butadiene, crotonaldehyde, cyanide, and ethylbenzene-styrene. Thus, constituents other than VOCs in tobacco smoke affect excretion of certain VOC metabolites differently among males and females. Non-Hispanic whites (NHW) had higher adjusted levels than non-Hispanic blacks (NHB) for 8 metabolites. NHB had statistically significantly lower adjusted levels than Hispanics for 5 VOC metabolites and lower levels than non-Hispanic Asians (NHAS) for 6 metabolites. Hispanics had statistically significantly higher levels than NHAS for 5 metabolites. Levels of 11 of the 19 metabolites analyzed increased with increase in age. Exposure to environmental tobacco smoke at home was associated with increased levels of 9 metabolites. Increase in the number of days tobacco products were used during the last five days was associated with increased levels of 12 of the 19 VOC metabolites.
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Ram B
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Jain
D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D000367:Age Factors; D000393:Air Pollutants / Q000652:urine*; D001213:Asian / Q000706:statistics & numerical data; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D012737:Sex Factors; D014028:Tobacco Smoke Pollution / Q000032:analysis*; D014481:United States / Q000208:ethnology; D055549:Volatile Organic Compounds / Q000652:urine*
D000393:Air Pollutants; D014028:Tobacco Smoke Pollution; D055549:Volatile Organic Compounds
Lifestyles; NHANES; Smoking; Urinary metabolites of volatile organic compounds