Primary cutaneous follicular helper T-cell lymphoma.
Follicular helper T-cells (TFH) represent a specific subset of CD4-positive helper T-cells that help B-cells to differentiate into long-lived antibody-secreting plasma cells or memory B-cells. The expression of TFH markers in neoplastic T-cells, traditionally related to the angioimmunoblastic (AITL) subgroup of peripheral T-cell lymphomas, is nowadays well-known to be more widespread than previously thought. We report hereby a case of cutaneous T-cell lymphoma in a 75-year-old woman, whose morphological and immunophenotypical features raises the differential diagnosis between cutaneous involvement by AITL and the recently described primary cutaneous T-cell lymphoma with follicular helper-phenotype.
Pathology Department, Fundación Jiménez Díaz, Madrid, Spain.
Carlos
C
Santonja
Hematology Department, Fundación Jiménez Díaz, Madrid, Spain.
Carlos
C
Soto
Pathology Department, Fundación Jiménez Díaz, Madrid, Spain.
Rebeca
R
Manso
Dermatology Department, Fundación Jiménez Díaz, Madrid, Spain.
Luis
L
Requena
Pathology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Miguel Angel
MA
Piris
Pathology Department, Fundación Jiménez Díaz, Madrid, Spain.
Socorro María
SM
Rodríguez-Pinilla
D000368:Aged; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000473:pathology
PD-1; cutaneous; helper T-cells; lymphomas; skin