Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study.
BACKGROUND
Several studies reported prognostic value of biomarker in intracerebral hemorrhagic (ICH) but they are either preliminary observation or inadequately powered to analyse independent contribution of biomarkers over and above clinical and neuroimaging data.


OBJECTIVE
To examine whether the biomarker can significantly add to the predictive accuracy of prognosis of ICH.


METHODS
In a multi-centric prospective cohort study, 1020 patients with ICH within 72 hours of onset are being recruited. After obtaining written informed consent from patients/proxy, venous blood sample (10 ml) is being collected and analysed for C-reactive protein (CRP) level, S100B, Glial fibrillary acidic protein (GFAP), Troponin, change in leukocyte count and Copeptin levels. The patients are telephonically followed using stroke scales (Barthel Index and modified Rankin Scale) at 3, 6, 12 months and 2 years after the recruitment.


CONCLUSIONS
This protocol will aim at predicting the short term or long term prognosis with the use of clinical, neuroimaging and biomarkers in order to help clinician to stratify patients for early referral or intervention.
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
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Kumar
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
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Kumar
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
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Misra
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
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Sagar
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
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Kathuria
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
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Vibha
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
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Vivekanandhan
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
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A
Garg
Department of Neurology, Safdarjung, Hospital, New Delhi, India.
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B
Kaul
Department of Neurology, Safdarjung, Hospital, New Delhi, India.
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Raghvan
Department of Neurology, Research and Referral Army Hospital, New Delhi, India.
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Gorthi
Pt. B.D. Sharma, PGIMS, Rohtak, India.
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Dabla
Sir Ganga Ram Hospital, New Delhi, India.
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Aggarwal
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India. drkameshwarprasad@gmail.com.
Kameshwar
K
Prasad
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006020:Glycopeptides / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012107:Research Design; D064568:S100 Calcium Binding Protein beta Subunit / Q000378:metabolism; D020521:Stroke / Q000097:blood* / Q000175:diagnosis; D016896:Treatment Outcome; D014336:Troponin / Q000378:metabolism; D055815:Young Adult
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D006020:Glycopeptides; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D014336:Troponin; C048197:copeptins; D002097:C-Reactive Protein