Uniform Reduction of Scalar Coupling by Real-Time Homonuclear J-Downscaled NMR.
Scalar coupling in proton NMR spectra provides important information for the structural analysis. However, the low resolution due to the resulting signal splitting, together with the rather narrow spectral range of hydrogen, often prevents the extraction of J-coupling information. Here we present a method to achieve real-time homonuclear J-downscaling. Thereby, all J-values are uniformly reduced by an arbitrary scaling factor. In the resulting one-dimensional spectra, signal overlap is reduced, while scalar coupling information is still available.
Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010, Graz, Austria.
Simon
S
Glanzer
Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010, Graz, Austria. klaus.zangger@uni-graz.at.
Klaus
K
Zangger
D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*
J-scaling; NMR spectroscopy; scalar coupling; slice-selective excitation; structure analysis