New developments in immunotherapies for food allergy.
Food allergy affects around 10% of the population. As the prevalence of food allergy continues to increase, disproportionately in children, new therapies for food allergy are being investigated. While there are no approved treatments for food allergy, immunotherapy facilitates significant desensitization and protection from accidental exposure. Nevertheless, current immunotherapies do not entirely nor permanently eliminate sensitivity to the food allergen. Since the rates of sustained unresponsiveness are significantly lower than desensitization, future therapies that enhance the rates of long-term tolerance in patients will catalyze progress in this field over the next 5-10 years.
Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Krishan Dilip
KD
Chhiba
Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Anne Marie
AM
Singh
Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Paul J
PJ
Bryce
D001491:Basophils / Q000276:immunology; D002648:Child; D003888:Desensitization, Immunologic / Q000379:methods; D005512:Food Hypersensitivity / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D008407:Mast Cells / Q000276:immunology; D063729:Sublingual Immunotherapy / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology
OIT; SLIT; food allergy; immunological tolerance; immunotherapy; omalizumab; oral immunotherapy; sublingual immunotherapy