Lymphatic Dissemination in Cutaneous Leishmaniasis Following Local Treatment.
Cutaneous leishmaniasis (CL) is diverse in its clinical presentation but usually demonstrates an erythematous, infiltrated, ulcerated, and crusted papule or nodule in exposed areas of the body. Rare clinical features have been reported including lymphatic dissemination, usually with subcutaneous nodules along lymphatic channels. Herein, we present six patients suffering from Old World CL with lymphatic dissemination characterized by sporotrichoid subcutaneous nodules along the lymphatic channels draining the primary lesion. Patients' history, clinical and laboratory findings were collected and summarized. Lymphatic dissemination of CL in our patients manifested as subcutaneous nodules without epidermal involvement within the axis of lymphatic drainage toward the regional lymph node, at times accompanied by regional lymphadenopathy. In all patients, the lymphatic dissemination was not present at initial diagnosis of CL, appearing only after local (topical or intralesional) treatment was initiated. In three patients, the subcutaneous nodules resolved without systemic treatment. Lymphatic dissemination of Old World CL is not uncommon and may possibly be triggered by local treatment. It should be recognized by dermatologists, especially those working in endemic areas. Systemic treatment may be not necessary since spontaneous resolution may occur.
Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Elena
E
Thomaidou
Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Liran
L
Horev
Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Deborah
D
Jotkowitz
Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Mariana
M
Zamir
Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Arieh
A
Ingber
Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Claes D
CD
Enk
Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel rverem@hadassah.org.il.
Vered
V
Molho-Pessach
D000287:Administration, Topical; D000293:Adolescent; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D016773:Leishmaniasis, Cutaneous / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008198:Lymph Nodes / Q000469:parasitology / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology / Q000469:parasitology*; D008297:Male
D000981:Antiprotozoal Agents