Nocarbenzoxazoles A-G, Benzoxazoles Produced by Halophilic Nocardiopsis lucentensis DSM 44048.
Seven new benzoxazole derivatives, nocarbenzoxazoles A-G (1-7), were isolated from the halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS, and X-ray single-crystal diffraction. The isolated compounds were assayed for their cytotoxicity against a panel of human tumor cell lines (HepG2, MDA-MB-231, MDA-MB-435, HeLa, and PC3). Compounds 1-6 were found to have modest or no activity. Compound 7 showed selective activity against HepG2 and HeLa with IC₅₀ values of 3 and 1 μM, respectively.
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan, Shandong 250012, People's Republic of China.
Mingwei
M
Sun
Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University , Kunming, Yunnan 650091, People's Republic of China.
Xiaomei
X
Zhang
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan, Shandong 250012, People's Republic of China.
Huilin
H
Hao
Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University , Kunming, Yunnan 650091, People's Republic of China.
Wenjun
W
Li
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan, Shandong 250012, People's Republic of China.
Chunhua
C
Lu
D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D001583:Benzoxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009615:Nocardia / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001583:Benzoxazoles; C000603009:nocarbenzoxazole G