Strategies to compare clinical antitherapeutic antibody data when changing assay platforms: a case study.
Zhihua Julia Qiu has over 20 years post PhD experience in academic institutes, pharmaceutical industry and biotechnology startup settings; focused on novel therapeutics discovery and development and diagnostic tools. She is currently a Scientist in the Bioanalytical Sciences department at Genentech; responsible for developing, evaluating and implementing Bioanalytical strategy to support protein therapeutics development. That includes assay development and validation to evaluate PK, antitherapeutic antibodies as well as biomarkers in both nonclinical and clinical studies for Immunology and Oncology indications. In addition, she has led the evaluation of multiple novel technology platforms and transitioning assay platform to enable continuous support for the development of protein therapeutics and antibody-drug conjugates.
Department of Bioanalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Zhihua Julia
ZJ
Qiu
Department of Bioanalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Yong
Y
Ying
Department of Nonclinical Biostatistics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Sock-Cheng
SC
Lewin-Koh
Department of Nonclinical Biostatistics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Daniel
D
Coleman
Department of Bioanalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Suzanne
S
Brignoli
Department of Bioanalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Robert
R
Hendricks
Department of Bioanalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Patricia
P
Siguenza
Department of Bioanalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Valerie
V
Quarmby
Department of Bioanalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Saloumeh K
SK
Fischer
Department of Bioanalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
An
A
Song
D000911:Antibodies, Monoclonal / Q000276:immunology*; D015195:Drug Design; D006801:Humans; D018796:Immunoconjugates / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D018796:Immunoconjugates