Long-term non-invasive ventilation therapies in children: a scoping review protocol.
BACKGROUND
Non-invasive ventilation (NIV) in children has become an increasingly common modality of breathing support where pressure support is delivered through a mask interface or less commonly through other non-invasive interfaces. At this time, NIV is considered a first-line option for ventilatory support of chronic respiratory insufficiency associated with a range of respiratory and sleep disorders. Previous reviews on the effectiveness, complications and adherence to NIV treatment have lacked systematic methods. The purpose of this scoping review is to provide an overview of the evidence for the use of long-term NIV in children.


METHODS
We will use previously established scoping methodology. Ten electronic databases will be searched to identify studies in children using NIV for longer than 3 months outside an intensive care setting. Grey literature search will include conference proceedings, thesis and dissertations, unpublished trials, reports from regulatory agencies and manufacturers. Two reviewers will independently screen titles and abstracts for inclusion, followed by full-text screening of potentially relevant articles to determine final inclusion. Data synthesis will be performed at three levels: (1) an analysis of the number, publication type, publication year, and country of publication of the studies; (2) a summary of the study designs, outcomes measures used; (3) a thematic analysis of included studies by subgroups.


BACKGROUND
This study will provide a wide and rigorous overview of the evidence on the use of long-term NIV in children and provide critical information for healthcare professionals and policymakers to better care for this group of children. We will disseminate our findings through conference proceedings and publications, and evaluate the results for further systematic reviews and meta-analyses.
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Stollery Children's Hospital, Edmonton, Alberta, Canada.
Maria L
http://orcid.org/0000-0002-1079-2502
ML
Castro Codesal
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Alberta Research Centre for Health Evidence, University of Alberta, Edmonton, Alberta, Canada.
Robin
R
Featherstone
Department of Pediatrics, Hospital La Paz, Madrid, Spain.
Carmen
http://orcid.org/0000-0002-6556-4208
C
Martinez Carrasco
Department of Pediatrics, University of Ottawa and Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Sherri L
SL
Katz
Department of Respiratory Medicine, Great Ormond Street Hospital for Children, London, UK.
Elaine Y
http://orcid.org/0000-0003-4846-2725
EY
Chan
Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Glenda N
GN
Bendiak
Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.
Fernanda R
FR
Almeida
Stollery Children's Hospital, Edmonton, Alberta, Canada.
Rochelle
http://orcid.org/0000-0002-2699-0052
R
Young
Stollery Children's Hospital, Edmonton, Alberta, Canada.
Deborah
http://orcid.org/0000-0003-4271-651X
D
Olmstead
Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Karen A
KA
Waters
Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Collin
C
Sullivan
Sleep Medix Inc, Edmonton, Alberta, Canada.
Vicki
http://orcid.org/0000-0002-4013-2521
V
Woolf
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Alberta Research Centre for Health Evidence, University of Alberta, Edmonton, Alberta, Canada.
Lisa
L
Hartling
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Stollery Children's Hospital, Edmonton, Alberta, Canada.
Joanna E
http://orcid.org/0000-0001-7994-9910
JE
MacLean
D002648:Child; D002985:Clinical Protocols; D006801:Humans; D063087:Noninvasive Ventilation / Q000379:methods*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D012140:Respiratory Tract Diseases / Q000150:complications; D012893:Sleep Wake Disorders / Q000150:complications; D013997:Time Factors; D000098584:Scoping Reviews as Topic
Artificial, Respiration; Continuous positive airway pressure; Non invasive ventilation; PAEDIATRICS; Respiratory insufficiency