Biomimetic apatite-based composite materials obtained by spark plasma sintering (SPS): physicochemical and mechanical characterizations.
Nanocrystalline calcium phosphate apatites are biomimetic compounds analogous to bone mineral and are at the origin of the bioactivity of most biomaterials used as bone substitutes. Their unique surface reactivity originates from the presence of a hydrated layer containing labile ions (mostly divalent ones). So the setup of 3D biocompatible apatite-based bioceramics exhibiting a high reactivity requests the development of «low» temperature consolidation processes such as spark plasma sintering (SPS), in order to preserve the characteristics of the hydrated nanocrystals. However, mechanical performances may still need to be improved for such nanocrystalline apatite bioceramics, especially in view of load-bearing applications. The reinforcement by association with biopolymers represents an appealing approach, while preserving the advantageous biological properties of biomimetic apatites. Herein, we report the preparation of composites based on biomimetic apatite associated with various quantities of microcrystalline cellulose (MCC, 1-20 wt%), a natural fibrous polymer. The SPS-consolidated composites were analyzed from both physicochemical (X-ray diffraction, Fourier transform infrared, solid state NMR) and mechanical (Brazilian test) viewpoints. The preservation of the physicochemical characteristics of apatite and cellulose in the final material was observed. Mechanical properties of the composite materials were found to be directly related to the polymer/apatite ratios and a maximum crushing strength was reached for 10 wt% of MCC.
CIRIMAT Carnot Institute, UMR CNRS/INPT/UPS 5085, Université de Toulouse, Faculté de Pharmacie 35 chemin des maraichers, 31062, Toulouse Cedex 4, France, fabien.brouillet@univ-tlse3.fr.
Fabien
F
Brouillet
Danielle
D
Laurencin
David
D
Grossin
Christophe
C
Drouet
Claude
C
Estournes
Geoffroy
G
Chevallier
Christian
C
Rey
D001031:Apatites / Q000138:chemical synthesis / Q000737:chemistry*; D001696:Biomechanical Phenomena; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry*; D002516:Ceramics / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D058626:Plasma Gases; D033362:Powder Diffraction; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D001031:Apatites; D018786:Bone Substitutes; D058626:Plasma Gases