What is the effect of fasting on the lifespan of neurons?
Medical advancements have increased life expectancy but have consequently increased the incidence of age-related disease. Fasting or dietary restriction (DR) can help prevent these via anti-ageing effects; however, these effects in neurons are less well characterized. Here, a series of animal and human studies of the effects of DR on the structural and functional integrity of neurons and the underlying mechanisms are analyzed. DR improves the integrity of animal neurons via a wide range of possible mechanisms including changes in metabolism, oxidative damage, stress responses, growth factors, and gene expression. These mechanisms are extensively interlinked and point to an optimum range of calorie intake, above calorie deprivation and below burdensome calorie excess. Human studies also suggest that DR improves neuron integrity; however, due to ethical and methodological limitations, the most conclusive data on DR hinge upon on-going life-long monkey experiments. Rather than developing pharmacological mimetics of DR, our focus should be on educating the public about DR in order to minimize age-related disease.
St Catherine's College, University of Oxford, Manor Road, Oxford, Oxfordshire OX1 3UJ, UK. Electronic address: dilraj.kalsi@stcatz.ox.ac.uk.
Dilraj S
DS
Kalsi
D000375:Aging / Q000502:physiology*; D000818:Animals; D002149:Energy Intake / Q000502:physiology*; D005215:Fasting / Q000502:physiology*; D006801:Humans; D053858:Metabolic Networks and Pathways; D009474:Neurons / Q000378:metabolism*; D000066829:Neuroprotection / Q000502:physiology
Age-related disease; Anti-ageing; Calorie restriction; Dietary restriction; Fasting; Mechanisms; Neuron lifespan; Neurons