Bmpr1a Signaling in Cartilage Development and Endochondral Bone Formation.
The type IA bone morphogenetic protein receptor (Bmpr1a), encoded by 11 exons and spanning about 40 kb on chromosome 14 in mice and chromosome 10 in human (Derynck & Feng, 1997; Mishina, Hanks, Miura, Tallquist, & Behringer, 2002), is an essential receptor for BMP signaling. This chapter focuses on the current understanding of the role of Bmpr1a in cartilage development and endochondral ossification, including formation of the mesenchymal condensation, chondrocyte differentiation and maturation, and endochondral bone development.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Junjun
J
Jing
Department of Biomedical Sciences, Texas A&M Baylor College of Dentistry, Dallas, Texas, USA.
Robert J
RJ
Hinton
Department of Biomedical Sciences, Texas A&M Baylor College of Dentistry, Dallas, Texas, USA. Electronic address: jfeng@bcd.tamhsc.edu.
Jian Q
JQ
Feng
D000818:Animals; D052005:Bone Morphogenetic Protein Receptors, Type I / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002356:Cartilage / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D019902:Chondrocytes / Q000166:cytology* / Q000378:metabolism; D020219:Chondrogenesis / Q000502:physiology*; D006801:Humans; D051379:Mice; D010012:Osteogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D019485:Bone Morphogenetic Proteins; C498211:BMPR1A protein, human; D052005:Bone Morphogenetic Protein Receptors, Type I
Articular cartilage; Bmpr1a; Cartilage development; Cell fate; Endochondral bone formation; Growth plate; Mandibular condylar cartilage; Temporomandibular joint