Gold-Catalyzed Cycloisomerization and Diels-Alder Reaction of 1,6-Diyne Esters with Alkenes and Diazenes to Hydronaphthalenes and -cinnolines.
A method for the efficient preparation of hydronaphthalene and -cinnoline derivatives by Au(I)-catalyzed cycloisomerzation of 1,6-diyne esters followed by a Diels-Alder reaction with alkenes or diazenes under mild conditions at room temperature with catalyst loadings as low as 1 mol % is described.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637371, Singapore.
Jianming
J
Yan
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637371, Singapore.
Guan Liang
GL
Tay
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637371, Singapore.
Cuien
C
Neo
School of Chemistry, Monash University , Clayton, Victoria 3800, Australia.
Bo Ra
BR
Lee
School of Chemistry, Monash University , Clayton, Victoria 3800, Australia.|Department of Chemistry, University of Warwick , Coventry, CV4 7AL, United Kingdom.
Philip Wai Hong
PW
Chan
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D006046:Gold / Q000737:chemistry*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry*; D007094:Imides / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*
D004952:Esters; D006574:Heterocyclic Compounds, 2-Ring; D007094:Imides; D009281:Naphthalenes; D006046:Gold; C038867:diazene; C476282:cinnoline