[Pathology and pathogenesis of liver fibrosis induced by Schistosoma japonicum].
Schistosomiasis is a widely distributed parasitic zoonoses that threatens human' s health and social economic development. China is one of the most endemic countries in the world. Schistosoma egg are mainly lodged in the liver and intestinal tissues. There, the eggs induce a granulomatous host immune response largely characterized by lymphocytes, eosinophils, and alternatively activated macrophages. The process of granuloma formation induces chronic inflammation that leads to liver fibrosis accompanied by obvious manifestations such as hepatosplenomegaly and ascites. In this article, we review the advanced progress in research about schistosomiasis hepatic fibrosis, including the pathology of liver fibrosis, the formation and modulation of granuloma and fibrosis, the key inflammatory factors and related signaling pathways, the regulatory role of ncRNA in the process of fibrosis, and anti-fibrosis treatment and new drugs development.
Lan-gui
LG
Song
Zhong-dao
ZD
Wu
D016207:Cytokines / Q000502:physiology; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D022661:RNA, Untranslated / Q000502:physiology; D012554:Schistosomiasis japonica / Q000150:complications*; D015398:Signal Transduction
D016207:Cytokines; D022661:RNA, Untranslated