Lipid profile but not highly sensitive C-reactive protein helps distinguish prehypertensives from normal subjects.
BACKGROUND
Early identification of the prehypertensive state can greatly improve the disease risk management. Although increased levels of highly sensitive C-reactive protein (hsCRP) and dyslipidemia is reported among patients with hypertension, the correlation of these parameters among prehypertensives in not known. Hence, the present study was designed to compare the levels of serum hsCRP and lipid profile among prehypertensives and normal subjects and correlate it with blood pressure (BP) levels.


METHODS
Anthropometric measurements and BP were recorded in 40 prehypertensive and 40 normal subjects. Subjects were assigned to a group based on their BP as per Joint National Committee 7 criteria. Serum hsCRP and lipid profile were measured and correlated with BP levels.


RESULTS
Serum hsCRP showed no significant difference between the two groups. There was no significant correlation of BP with hsCRP in both the groups. Total cholesterol (TC) and low-density lipoprotein (LDL) were significantly increased in prehypertensives as compared to normal subjects. There was no significant association between BP and lipid parameters in prehypertensives.


CONCLUSIONS
Significant increase of TC and LDL but not hsCRP was evident among prehypertensives as compared to normal subjects.
Department of Physiology, JSS Medical College, SS Nagar, Mysore, Karnataka, India.
T
T
Bharath
Department of Physiology, Vijayanagar Institute of Medical Sciences, Contonment, Bellary, Karnataka, India.
P
P
Manjula
Highly sensitive C-reactive protein; lipid profile; prehypertension