Relevance between HLA-DP gene rs2281388 polymorphism and hepatocellular carcinoma risk.
OBJECTIVE
We carried out this study to find out the relevance between rs2281388 T/C polymorphism of human leukocyte antigen (HLA) gene and hepatocellular carcinoma (HCC) risk in Chinese Han population.


METHODS
The method of polymerase chain reaction (PCR) was applied to amplify the genomic DNA. Then the PCR products were sequenced to test the HLA-DP gene rs2281388T/C polymorphism of the case and control groups. Odds ratios (ORs) and 95% confidence interval (95% CIs) were utilized to evaluate the potential correlation between rs2281388 variants and HCC risk.


RESULTS
We analyzed the rs2281388 polymorphism distribution among the clinical pathological features. The results showed that there existed a significant statistic correlation between rs2281388T/C polymorphism of HLA-DP gene and HBsAg feature, and no significant correlation was found between rs2281388 and other clinical features. Further analysis showed that the TT genotype of rs2281388 was significantly correlated with HCC risk, and the same to T allele, but there was no significant difference of CT genotype distribution in case and control groups.


CONCLUSIONS
TT genotype and T allele of HLA-DP gene rs2281388 polymorphism may increase the risk of HCC.
Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
Fangfeng
F
Liu
Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiiated to Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
Jianlu
J
Wang
Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
Hong
H
Chang
Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
Jun
J
Lu
Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
Hongguang
H
Li
D000368:Aged; D044466:Asian People / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006682:HLA-DP Antigens / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D006682:HLA-DP Antigens
HLA-DP gene; hepatocellular carcinoma; single nucleotide polymorphism