Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation.
Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions.
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://hamilton.chem.ox.ac.uk.
Jonathan E
JE
Ross
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://hamilton.chem.ox.ac.uk.
Peter C
PC
Knipe
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://hamilton.chem.ox.ac.uk. sam.thompson@chem.ox.ac.uk.
Sam
S
Thompson
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://hamilton.chem.ox.ac.uk. andrew.hamilton@chem.ox.ac.uk.
Andrew D
AD
Hamilton
D000480:Alkynes / Q000737:chemistry*; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D017433:Protein Structure, Secondary
D000480:Alkynes; D004151:Dipeptides
foldamer; peptidomimetics; protein surface; protein-protein interaction; secondary structure; β-sheet