Granulin levels in patients with idiopathic premature ovarian failure.
OBJECTIVE
With the prolongation of expected lifespan, premature ovarian failure (POF) has gained increased significance as a crucial female health problem. Here we aimed to investigate the diagnostic value of the levels of the growth factor Granulin, which has been associated with epithelial ovarian carcinoma, in the pathogenesis of POF.


METHODS
Thirty-one patients with POF and 57 patients as a control group were recruited for this study in a tertiary referral center in the capital of Turkey. Granulin levels and individual characteristics of the two groups were compared.


RESULTS
Age and body mass indices were similar between the two groups. Granulin levels in patients with POF (2.94±1.91ng/mL) were significantly lower than in the control group (4.77±1.62ng/mL) (p<0.001).


CONCLUSIONS
Future larger studies should focus on Granulin levels and its correlation with ovarian reserve markers, its clinical applicability, and its possible therapeutic value, thus providing further insight into the role of Granulin in the pathogenesis of POF.
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey. Electronic address: draliersoy@gmail.com.
Ali Ozgur
AO
Ersoy
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey.
Efser
E
Oztas
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey.
Ebru
E
Ersoy
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey.
Sibel
S
Ozler
Department of Biochemistry, Ataturk Education and Research Hospital, Ankara, Turkey.
Merve
M
Ergin
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey.
Nafiye
N
Yilmaz
D000328:Adult; D000367:Age Factors; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D065851:Ovarian Reserve; D016649:Primary Ovarian Insufficiency / Q000097:blood* / Q000175:diagnosis*; D000077153:Progranulins; D011446:Prospective Studies; D012372:ROC Curve
D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins; D005640:Follicle Stimulating Hormone
Granulin; Growth factor; Marker; Ovarian reserve; Premature ovarian failure