Generalized seizures in a neural field model with bursting dynamics.
The mechanisms underlying generalized seizures are explored with neural field theory. A corticothalamic neural field model that has accounted for multiple brain activity phenomena and states is used to explore changes leading to pathological seizure states. It is found that absence seizures arise from instabilities in the system and replicate experimental studies in numerous animal models and clinical studies.
School of Physics, The University of Sydney, Sydney, New South Wales, 2006, Australia. xzha6112@uni.sydney.edu.au.|Center for Integrative Brain Function, University of Sydney, NSW, 2006, Australia. xzha6112@uni.sydney.edu.au.|Neurosleep, 431 Glebe Point Rd, Glebe, New South Wales, 2037, Australia. xzha6112@uni.sydney.edu.au.|Cooperative Research Center for Alertness, Safety, and Productivity, University of Sydney, NSW, 2006, Australia. xzha6112@uni.sydney.edu.au.
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Zhao
School of Physics, The University of Sydney, Sydney, New South Wales, 2006, Australia.|Center for Integrative Brain Function, University of Sydney, NSW, 2006, Australia.|Neurosleep, 431 Glebe Point Rd, Glebe, New South Wales, 2037, Australia.|Cooperative Research Center for Alertness, Safety, and Productivity, University of Sydney, NSW, 2006, Australia.
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Robinson
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D003198:Computer Simulation; D003712:Dendrites / Q000187:drug effects / Q000502:physiology; D005583:Fourier Analysis; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D017711:Nonlinear Dynamics; D012640:Seizures / Q000473:pathology*; D013788:Thalamus / Q000166:cytology / Q000502:physiology; D005680:gamma-Aminobutyric Acid
D005680:gamma-Aminobutyric Acid
Corticothalamic; Generalized seizures; Neural-field theory