Vascular adhesion protein-1: Role in human pathology and application as a biomarker.
Vascular adhesion protein-1 (VAP-1) is a member of the copper-containing amine oxidase/semicarbazide-sensitive amine oxidase (AOC/SSAO) enzyme family. SSAO enzymes catalyze oxidative deamination of primary amines, which results in the production of the corresponding aldehyde, hydrogen peroxide and ammonium. VAP-1 is continuously expressed as a transmembrane glycoprotein in the vascular wall during development and facilitates the accumulation of inflammatory cells into the inflamed environment in concert with other leukocyte adhesion molecules. The soluble form of VAP-1 is released into the circulation mainly from vascular endothelial cells. Over- and under-expression of sVAP-1 result in alterations of the reported reaction product levels, which are involved in the pathogenesis of multiple human diseases. The combination of enzymatic and adhesion capacities as well as its strong association with inflammatory pathologies makes VAP-1 an interesting therapeutic target for drug discovery. In this article, we will review the general characteristics and biological functions of VAP-1, focusing on its important role as a prognostic biomarker in human pathologies. In addition, the potential therapeutic application of VAP-1 inhibitors will be discussed.
a Department of Nephrology .
Roos
R
Pannecoeck
a Department of Nephrology .
Daphne
D
Serruys
a Department of Nephrology .
Lara
L
Benmeridja
b Department of Clinical Chemistry , and.
Joris R
JR
Delanghe
c Department of Dermatology , Ghent University Hospital , Gent , Belgium.
Nanja
N
van Geel
c Department of Dermatology , Ghent University Hospital , Gent , Belgium.
Reinhart
R
Speeckaert
a Department of Nephrology .
Marijn M
MM
Speeckaert
D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology; D019317:Evidence-Based Medicine; D005128:Eye Diseases / Q000097:blood / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000453:epidemiology; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D015995:Prevalence; D020521:Stroke / Q000097:blood* / Q000453:epidemiology
D015415:Biomarkers; D015815:Cell Adhesion Molecules; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)
Copper-containing amine oxidase; VAP-1; drug target; leukocyte trafficking; semicarbazide-sensitive amine oxidase; soluble cell adhesion molecules