Double-C loop platform in combination with hydrophobic and hydrophilic acrylic intraocular lens materials.
OBJECTIVE
To analyze the behavior of a new double-C-loop quadripod symmetrical intraocular lens (IOL) platform combined with a hydrophilic lens material and a new hydrophobic glistening-free acrylic lens material, Ankoris and Podeye, respectively, in silico (computer simulation), in vitro (laboratory investigation), and in vivo (rabbit model).


METHODS
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA, and Physiol S.A., Liege, Belgium.


METHODS
Experimental study.


METHODS
An in silico simulation investigation was performed using finite elements software, an in vitro investigation according to the International Organization for Standardization (ISO11979-3:2012), and an in vivo implantation in a rabbit model with 4 weeks of follow-up. Postmortem data were collected by Miyake-Apple gross examination and histopathologic analyses. Biocompatibility and IOL centration were tested.


RESULTS
Both IOLs demonstrated statistically insignificant variations in posterior and anterior capsule opacification and Soemmerring ring formation. They were well biotolerated with no signs of toxicity, inflammation, or neovascularization. Axial and centration stability were noted in vitro and in vivo as a result of significant contact between surrounding tissues and haptics and the posterior portion of the optic.


CONCLUSIONS
The results suggest suitability of the double-C loop IOL platform for the manufacturing of premium (ie, multifocal, toric, and multifocal toric) IOLs.


BACKGROUND
Drs. Bozukova, Gobin, and Pagnoulle are employees of Physiol S.A., Liege, Belgium. Dr. Pagnoulle has a proprietary interest in the tested intraocular lenses. No other author has a financial or proprietary interest in any material or method mentioned.
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA. Electronic address: d.bozukova@physiol.be.
Dimitriya
D
Bozukova
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA.
Liliana
L
Werner
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA.
Nick
N
Mamalis
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA.
Laure
L
Gobin
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA.
Christophe
C
Pagnoulle
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA.
Anne
A
Floyd
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA.
Erica
E
Liu
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA.
Shannon
S
Stallings
From Physiol S.A. (Bozukova, Gobin, Pagnoulle), Liege, Belgium; the John A. Moran Eye Center (Werner, Mamalis, Floyd, Liu, Stallings, Morris), University of Utah, Salt Lake City, Utah, USA.
Caleb
C
Morris
D000180:Acrylic Resins; D000818:Animals; D003198:Computer Simulation; D055119:Elastic Modulus; D020342:Finite Element Analysis; D057927:Hydrophobic and Hydrophilic Interactions; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D011474:Prosthesis Design; D011817:Rabbits
D000180:Acrylic Resins