Association of ultrasonographic features with NGX6 expression and prognosis in invasive ductal breast carcinoma.
BACKGROUND
Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a newly discovered tumor suppressor gene. It contains one epidermal growth factor (EGF)-like domain. Many studies have shown that proteins contain (EGF)-like domain structure affect a variety of biological actions. However, little is known about the relationships between NGX6 expression and biological behaviors in invasive ductal breast carcinoma (IDBC). The study discussed the association of ultrasonographic features with NGX6 expression and prognosis in IDBC.


METHODS
Ultrasonographic feature and clinical data in 122 patients with IDBC were retrospectively analyzed. NGX6 expression of IDBC was measured using immunohistochemistry methods.


RESULTS
The incidence of the burr sign, lymph node metastasis and abundance blood flow in NGX6 expression negative groups were higher than those in positive groups. Kaplan-Meier analysis showed that the association between NGX6 positive expression and higher disease-free survival (DFS) or higher overall survival (OS); Lymph node metastasis is associated with lower DFS or lower OS; Lower blood flow grade is associated with higher DFS. In univariate and multivariate survival analysis, NGX6 expression, lymph node metastasis, TNM and the blood flow grade were the independent prognostic factors for DFS and OS of IDBC.


CONCLUSIONS
ultrasonographic features are associated with NGX6 expression in IDBC. NGX6 is involved in the invasion and metastasis activity of IDBC. Our results suggest that NGX6 may be employed as a promising prognostic factor and useful therapeutic target for IDBC. Combination of ultrasonic findings and NGX6 detection may yield clinically useful information for IDBC prognosis.
Department of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha City 410013, Hunan Province, China.
Jidong
J
Xiao
Department of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha City 410013, Hunan Province, China.
Yuanquan
Y
Zhou
Department of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha City 410013, Hunan Province, China.
Wenhui
W
Zhu
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000098:blood supply / Q000737:chemistry* / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply / Q000737:chemistry* / Q000000981:diagnostic imaging* / Q000401:mortality / Q000556:secondary; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012039:Regional Blood Flow; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D025521:Tumor Suppressor Proteins / Q000032:analysis*; D016217:Ultrasonography, Mammary
D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C477325:TMEM8B protein, human; D025521:Tumor Suppressor Proteins
Invasive ductal breast carcinoma (IDBC); NGX6; prognosis; ultrasonography