Changes in presepsin concentrations in surgical patients with end-stage kidney disease undergoing living kidney transplantation: a pilot study.
Presepsin is a useful marker for differentiating sepsis from non-infection-related systemic inflammatory response syndrome. There are data describing elevated presepsin concentrations in patients with kidney dysfunction even in the absence of sepsis, but corresponding data for patients with end-stage kidney disease (ESKD) undergoing living kidney transplantation (LKT) are lacking. We investigated the changes in presepsin concentrations in this patient group in order to elucidate any relationship with renal function. Written informed consent was obtained from patients with ESKD requiring hemodialysis who underwent LKT from June 2014 through March 2015 at Hirosaki University Hospital. Patients with obvious signs of infection were excluded. Perioperative presepsin and procalcitonin concentrations were measured before induction of anesthesia, on admission to the intensive care unit after surgery, and on postoperative day (POD) 1 and POD 2. Preoperative presepsin concentration was markedly higher than the upper limit of normal in patients with ESKD (1252 ± 451 pg/mL). Presepsin concentrations consistently decreased after LKT. Moreover, presepsin concentration was strongly correlated with serum creatinine (r (2) = 0.72, n = 24, p < 0.001). These data suggest that the kidney clearly plays an important role in the metabolism and excretion of presepsin.
Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan. fix-you@hotmail.co.jp.
Junichi
J
Saito
Division of Intensive Care Unit, Hirosaki University Hospital, Hirosaki, Japan. ehashiba@pc4.so-net.ne.jp.
Eiji
E
Hashiba
Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan. tetsuyaK@hirosaki-u.ac.jp.
Tetsuya
T
Kushikata
Central Clinical Laboratory, Hirosaki University Hospital, Hirosaki, Japan. akiom@hirosaki-u.ac.jp.
Akio
A
Mikami
Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan. hirotak@hirosaki-u.ac.jp.
Kazuyoshi
K
Hirota
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000379:methods*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism*; D010865:Pilot Projects; D011498:Protein Precursors / Q000378:metabolism; D018805:Sepsis / Q000097:blood
D015415:Biomarkers; C000606589:CALCA protein, human; D018950:Lipopolysaccharide Receptors; D010446:Peptide Fragments; D011498:Protein Precursors; C000594167:presepsin protein, human; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide
End-stage kidney disease; Living kidney transplantation; Presepsin; Procalcitonin