Correlation between renin-angiotensin system gene polymorphisms and essential hypertension in the Chinese Yi ethnic group.
BACKGROUND
The renin-angiotensin system (RAS) has been considered to play an important role in the regulation of blood pressure. This study aimed to investigate the correlation between RAS gene polymorphisms and essential hypertension (EH) in the Chinese Yi ethnic group.


METHODS
A total of 244 EH subjects and 185 normotensive individuals from the Chinese Yi ethnic group were genotyped for AGT M235T (rs699), AT1R A1166C (rs5186), ACE I/D (rs4340) and ACE G2350A (rs4343) polymorphisms by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method.


RESULTS
Significant differences in the allele and genotype frequency of ACE G2350A were observed between the EH cases and controls (p=0.001, 0.002). After being grouped by gender, significant differences in the allele and genotype frequency of ACE G2350A and AT1R A1166C were observed between females of the EH cases and controls (ACE G2350A: p=0.000, 0.002; AT1R A1166C: p=0.008, 0.011). After excluding the influence of multifactorial interactions, the ACE G2350A polymorphism is significantly associated with the pathogenesis of EH in the Chinese Yi ethnic group (odds ratio (OR)=1.656, 95% confidence interval (CI) 1.807-2.524, p=0.019).


CONCLUSIONS
The RAS-related ACE G2350A polymorphism is associated with the pathogenesis of EH in the Chinese Yi ethnic group.
Department of Cell Biology and Medical Genetics, Kunming Medical University, China.
Yu-Ling
YL
Yang
Department of Geriatrics, The First Affiliated Hospital of Kunming Medical University, China.
Yan-Ping
YP
Mo
Department of Cell Biology and Medical Genetics, Kunming Medical University, China.
Yong-Shu
YS
He
Department of Cell Biology and Medical Genetics, Kunming Medical University, China.
Fang
F
Yang
Department of Pathogenic Biology and Immunology, Kunming Medical University, China.
Yan
Y
Xu
School of Basic Medical Science, Kunming Medical University, China.
Cheng-Cheng
CC
Li
School of Basic Medical Science, Kunming Medical University, China.
Jiao
J
Wang
School of Basic Medical Science, Kunming Medical University, China.
Hao-Ming
HM
Reng
Department of Cell Biology and Medical Genetics, Kunming Medical University, China 2001lli@sina.com.
Li
L
Long
D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D000075222:Essential Hypertension; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D054643:INDEL Mutation; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics*
ACE G2350A; ACE I/D; AGT M235T; AT1R A1166C; Chinese Yi ethnic group; Essential hypertension; genetic polymorphism