Primary pulmonary adenoid cystic carcinoma: clinicopathological analyses of 12 cases.
OBJECTIVE
Adenoid cystic primary pulmonary carcinomas (adenoid cystic carcinomas or ACCs) are rare tumors, so we described the clinical and pathological features of these tumors and related these findings with diagnosis and prognosis of ACC, comparing our data to the existing literature.


METHODS
Clinical and pathological features of 12 ACC cases were observed and described. Immunohistochemical EnVision staining, fluorescent PCR detection, and FISH were used to characterize tumor samples and the literature was reviewed.


RESULTS
Of the 12 ACC cases (7 male; average 53.1 years-of-age; range 33-78 years), the chief presentation symptom was cough, followed by expectoration, gasping, and bloody sputum. Microscopically, histopathology revealed cribriform, tubular, or solid cords. CD117 was overexpressed in glandular epithelia in 9 cases and calcitonin and thyroid transcription factor-1 (TTF-1) were overexpressed in 4 cases. One case was positive for EML4 ALK gene rearrangement.


CONCLUSIONS
ACC is a low-grade malignant tumor with poor prognosis and high recurrence and metastases. TTF-1 expression indicates a primary tumor and CD117 expression is not significant to prognosis.
Department of Pathology, First Affiliated Hospital, Xinjiang Medical University Urumqi 830054, China.
Song
S
Qing
Hypertension Center of The People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang Uygur Autonomous Region Urumuqi 830001, Xinjiang, China.
Keming
K
Zhou
Department of Pathology, First Affiliated Hospital, Xinjiang Medical University Urumqi 830054, China.
Xia
X
Liu
Department of Gynecology, First Affiliated Hospital, Xinjiang Medical University Urumqi 830054, China.
Xiaohong
X
Li
Department of Pathology, First Affiliated Hospital, Xinjiang Medical University Urumqi 830054, China.
Feiyan
F
Deng
Department of Pathology, First Affiliated Hospital, Xinjiang Medical University Urumqi 830054, China.
Yuqing
Y
Ma
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction
D014408:Biomarkers, Tumor
Adenoid cystic carcinoma; FISH; diagnosis; fluorescence PCR; prognosis; immunohistochemistry