Association Between the CYP1B1 Polymorphisms and Lung Cancer Risk: A Meta-Analysis.
The previously published data on the association between the cytochrome P450 1B1 Leu432Val, Asn453Ser, and Ala119Ser polymorphisms and lung cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between cytochrome P450 1B1 Leu432Val, Asn453Ser, and Ala119Ser polymorphisms and lung cancer risk under different inheritance models. A total of 22 studies were identified, including 2881 cases and 3653 controls for Leu432Val polymorphism (from 13 studies), 3009 cases and 3887 controls for Asn453Ser polymorphism (from 5 studies), and 1301 cases and 2045 controls for Ala119Ser polymorphism (from 4 studies). Overall, significant association was observed between cytochrome P450 1B1 Leu432Val polymorphism and lung cancer risk (dominant model: odds ratio = 1.29, 95% confidence interval = 1.08-1.53; recessive model: odds ratio = 1.21, 95% confidence interval = 1.05-1.39; additive model: odds ratio = 1.43, 95% confidence interval = 1.21-1.69) when all the eligible studies were pooled into the meta-analysis. In the further stratified and sensitivity analyses, significantly increased lung cancer risk was also observed in caucasians and smokers. No significant association was observed between cytochrome P450 1B1Asn453Ser and Ala119Ser polymorphisms and lung cancer risk in overall analysis. In summary, this meta-analysis suggests that cytochrome P450 1B1Leu432Val polymorphism is associated with increased lung cancer risk in caucasians and smokers.
Second Department of Internal Medicine, the Third People's Hospital of Shenzhen, Shenzhen, China.
Pei-Fen
PF
Chen
Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, China 393120823@qq.com.
Xiao-Feng
XF
He
Department of Respiration, Nanfang Hospital of Southern Medical University, Guangzhou, China.
Guo-Hua
GH
Huang
Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, China.
Wei
W
Wang
Department of Gastroscope Room, the Third People's Hospital of Shenzhen, Shenzhen, China.
Zhi-Hui
ZH
Qiu
D019943:Amino Acid Substitution; D016022:Case-Control Studies; D003062:Codon; D065633:Cytochrome P-450 CYP1B1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D003062:Codon; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1
CYP1B1; lung cancer; meta-analysis; polymorphism; risk