Close concordance between pulmonary angiography and pathology in a canine model with chronic pulmonary thromboembolism and pathological mechanisms after lung ischemia reperfusion injury.
To investigate the pulmonary angiography and pathology in a canine model with chronic pulmonary thromboembolism (PTE). The cylindrical blood clots were selectively introduced into the left (n = 10) or right (n = 20) lower pulmonary arteries of dogs. Pulmonary arteriography (PA) was performed before or after embolization. The values after embolization and baseline of mean pulmonary arterial pressure, pulmonary vascular resistance, cardiac output had changed. After 1 or 2 weeks' embolization, local PA demonstrated the abrupt cut-off perfusion defects or webs, bands, and abrupt vascular narrowing. 2 weeks after embolization, the pathology showed that the fibrin networks of the thrombi had multiple recanalization channels, and pulmonary artery had the concentric, lamellar (onion-like) intimal hyperplasia, multilayered, irregular arrangements of endothelial cells, and the infiltration of inflammatory cells. After embolectomy-mediated reperfusion, 2 weeks' subgroup showed destroyed and incomplete alveolar structures, and a large number of exudative cells, primarily neutrophils, and exudate. There close concordance between pulmonary angiography and pathology in a canine model with chronic PTE. The LIRI mechanisms after embolectomy-mediated reperfusion involve the destroyed, incomplete alveolar structures, and infiltration of inflammatory cells, primarily neutrophils.
Division of Respiratory and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China. jasonsci7333@163.com.
Chaosheng
C
Deng
Division of Respiratory and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Dawen
D
Wu
Division of Respiratory and Critical Care Medicine, Beijing Institution of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Zhenguo
Z
Zhai
Division of Respiratory and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Qichang
Q
Lin
Division of Respiratory and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Zhanghua
Z
Zhong
Division of Respiratory and Critical Care Medicine, Beijing Institution of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Yuanhua
Y
Yang
Department of Medical Imaging, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Qunlin
Q
Chen
Division of Respiratory and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Ningfang
N
Lian
Division of Respiratory and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Shaoyong
S
Gao
Division of Respiratory and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Minxia
M
Yang
Division of Respiratory and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Kaixiong
K
Liu
Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Institute of Respiratory Medicine, Beijing Hospital, Ministry of Health, Beijing, 100730, China.
Chen
C
Wang
D000792:Angiography; D000818:Animals; D001794:Blood Pressure; D002908:Chronic Disease; D004195:Disease Models, Animal; D004285:Dogs; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000503:physiopathology; D015427:Reperfusion Injury / Q000000981:diagnostic imaging / Q000503:physiopathology; D014655:Vascular Resistance
Animal model; Lung ischemia reperfusion injury; Pathology; Pulmonary angiography; Pulmonary thromboembolism