Large Malignant Phyllodes Tumor of the Breast with Metastases to the Lungs.
Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old. The importance in managing fibroepithelial lesions lies in distinguishing fibroadenomas, which are benign, from phyllodes tumors, which can be malignant and require complete surgical excision. We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple. The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor. Surgical resection is the primary treatment modality; neoadjuvant and adjuvant therapies remain controversial. Here, we report the case of a large malignant phyllodes tumor metastatic to the lungs, review the literature, and discuss diagnostic modalities and adjunct nonsurgical therapies.
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center , Dallas, TX, USA ; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX, USA.
Alexander
A
Augustyn
Department of Pathology, University of Texas Southwestern Medical Center , Dallas, TX, USA.
Sunati
S
Sahoo
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX, USA ; Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center , Dallas, TX, USA.
Rachel D
RD
Wooldridge
Phyllodes tumor; breast; metastatic; surgery