Liver transplantation from living donors with Gilbert's syndrome is a safe procedure for both donors and recipients.
Liver transplantation (LT) has become a favorable therapeutic option for patients with end-stage liver diseases. Gilbert's syndrome (GS) is a benign condition characterized by intermittent mild jaundice due to unconjugated hyperbilirubinemia. It is not obvious whether living-donor liver transplantation (LDLT) from a donor with GS could result in a normal outcome for both the recipient and the donor. We aimed to determine whether right lobe hepatectomy is a safe procedure for living donors with GS and LT recipients. Between September 2011 and March 2015, 305 LDLT procedures using right lobe grafts were performed at Atasehir Memorial Hospital, Istanbul, Turkey. Nineteen of 305 LT candidates who had been diagnosed with GS were included in the current study. After a 12-h overnight fast, total and indirect bilirubin levels of donors and recipients were measured. The median follow-up after transplant was 16 months (range 3-36 months). The median age of donors was 25 (range 20-55 yr). Four donors (21%) were female, and 15 donors (89%) were male. The median age of donors was 51 (range 23-68 yr). Eleven recipients (57%) were female, and 8 (43%) were male. The median preoperative total bilirubin level of donors was 1.69 mg/dL (range 1.26-2.43 mg/dL) (normal range <1.2 mg/dL). The median total bilirubin level of donors on postoperative day 7 was 1.04 mg/dL (range 0.71-3.23 mg/dL). As our study has included a large number of donors with GS, it produced reliable evidence that right lobe hepatectomy is a safe procedure for living donors with GS and LT recipients.
Department of Gastroenterology, GATA Haydarpasa Training Hospital, İstanbul, Turkey.
Alpaslan
A
Tanoglu
Department of General Surgery, Istanbul Medeniyet University, Istanbul, Turkey.
Tarik
T
Artis
Department of Transplant Surgery, Memorial Atasehir Hospital, Istanbul, Turkey.
Ramazan
R
Donmez
Department of Transplant Surgery, Memorial Atasehir Hospital, Istanbul, Turkey.
Ahmet
A
Kargi
Department of Transplant Surgery, Memorial Atasehir Hospital, Istanbul, Turkey.
Mustafa
M
Sit
Department of Transplant Surgery, Memorial Atasehir Hospital, Istanbul, Turkey.
Serdar
S
Aslan
Department of Transplant Surgery, Memorial Atasehir Hospital, Istanbul, Turkey.
Serafettin
S
Yazar
Department of Gastroenterology, Canakkale State Hospital, Canakkale, Turkey.
Yavuz
Y
Beyazit
Department of Transplant Surgery, Memorial Atasehir Hospital, Istanbul, Turkey.
Kamil Yalcin
KY
Polat
D000328:Adult; D000368:Aged; D046148:Donor Selection; D058625:End Stage Liver Disease / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005878:Gilbert Disease / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D008111:Liver Function Tests; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
Gilbert's syndrome; hyperbilirubinemia; living-donor liver transplantation; recipient; right hepatectomy