Synthesis of bicyclic tetrahydrofurans from linear precursors using manganese(III) acetate.
We have recently developed methodology based on oxidative radical reactions for the synthesis of [3.3.0]-bicyclic lactones containing both cyclopentanes and γ-lactams along with application of this methodology to the synthesis of natural products and complex molecular architectures. Herein we report an extension of this methodology to the synthesis of oxygen heterocycles including bicyclic bis-lactones.
Department of Chemistry, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK. jonathan.burton@chem.ox.ac.uk.
Anne-Caroline
AC
Chany
Léo B
LB
Marx
Jonathan W
JW
Burton
D000085:Acetates / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry
D000085:Acetates; D005663:Furans; D007783:Lactones; D009942:Organometallic Compounds; C521134:manganese(III) acetate dihydrate; D010100:Oxygen