[Study on effect of pH on rectum permeability of active ingredients in Reduning suppositories in vitro].
OBJECTIVE
To investigate the effect of different pH on rectum permeability of chlorogenic acid and geniposide.


METHODS
Four kinds of Reduning suppositories of different pH were separated and put into the rectum to study the suppositories in vitro and the content of chlorogenic acid and geniposide samples was determined by HPLC to calculate the permeation in 24 hours.


RESULTS
With increase of pH within 2.5-7.4, the steady state flux of chlorogenic acid was increased, but the steady state flux of geniposidesamples was steady.


CONCLUSIONS
Adjusted the pH can increase the rectum permeability of active ingredients in Reduning auppositories.
Ming
M
Yan
Ying-chun
YC
Wei
Jin
J
Meng
Dian-hong
DH
Xu
Yun
Y
Wu
Wei
W
Xiao
D000818:Animals; D002726:Chlorogenic Acid / Q000493:pharmacokinetics; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D039823:Iridoids / Q000493:pharmacokinetics; D008297:Male; D010539:Permeability; D051381:Rats; D017207:Rats, Sprague-Dawley; D012007:Rectum / Q000378:metabolism*; D013488:Suppositories / Q000493:pharmacokinetics*
D004365:Drugs, Chinese Herbal; D039823:Iridoids; D013488:Suppositories; C007835:geniposide; D002726:Chlorogenic Acid