Longitudinal relationship between insulin-like growth factor-1 levels and vertical facial growth.
BACKGROUND
Facial growth in the vertical dimension is the last to be completed and can often be detrimental to the success of dental implants, orthodontic treatment, and orthognathic surgery that young individuals undergo.


OBJECTIVE
The purpose of this study was to evaluate the longitudinal relationship between changes in total anterior facial height and insulin-like growth factor-1 (IGF-1) levels measured using blood-spot samples.


METHODS
Our sample included 25 orthodontic patients from whom we had access to annual lateral cephalometric radiographs and IGF-1 measurements. Each subject was observed between 2 and 6 times, resulting in 43 annual intervals from a total of 77 observations.


RESULTS
We noted a significant moderate positive correlation (+ 0.48) between the percentage of change in blood-spot IGF-1 levels and the percentage of change in total anterior face height (p = 0.01).


CONCLUSIONS
Longitudinal changes in IGF-1 levels can be used to predict a patient's vertical facial growth. There was no significant correlation between changes in vertical facial development and a single cross-sectional IGF-1 measurement.
Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, 02115, Boston, MA, USA. mohamed_masoud@hsdm.harvard.edu.|Department of Orthodontics, King Abdulaziz University, Jeddah, Saudi Arabia. mohamed_masoud@hsdm.harvard.edu.
Mohamed I
MI
Masoud
Department of Orthodontics, King Abdulaziz University, Jeddah, Saudi Arabia.|Department of Orthodontics, University of Buffalo, Buffalo, NY, USA.
Hussain Y A
HY
Marghalani
Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Najlaa M
NM
Alamoudi
Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.|Public Health and Community Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Douaa
D
El Derw
Dr. Ibrahim Masoud's Dental Specialty Clinic, Jeddah, Saudi Arabia.
Ibrahim M
IM
Masoud
Department of Pediatric Dentistry, Tufts School of Dental Medicine, Boston, MA, USA.
Nour F
NF
Gowharji
D000293:Adolescent; D000375:Aging / Q000097:blood* / Q000502:physiology; D002508:Cephalometry / Q000379:methods; D002648:Child; D005145:Face / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D008445:Maxillofacial Development / Q000502:physiology*; D011861:Radiography, Dental / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014716:Vertical Dimension; D055815:Young Adult
D007334:Insulin-Like Growth Factor I
Craniofacial biology; Dental implants; Developmental biology; Growth prediction; Orthognathics