LincRNA-p21: Implications in Human Diseases.
Long noncoding RNAs (lncRNAs), which lack significant protein-coding capacity, regulate various biological processes through diverse and as yet poorly understood molecular mechanisms. However, a number of studies in the past few years have documented important functions for lncRNAs in human diseases. Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases. In this review, we summarize the current knowledge of lincRNA-p21, mainly focus on the known biological functions and its underlying mechanisms. Moreover, we highlight the growing body of evidences for the importance of lincRNA-p21 in diverse human diseases, which indicate lincRNA-p21 as a potential diagnostic marker and/or a valuable therapeutic target for these diseases.
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China. saisaitang1988@126.com.|Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China. saisaitang1988@126.com.|Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China. saisaitang1988@126.com.
Sai-Sai
SS
Tang
Institute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, China. zby88kr@163.com.
Bi-Ying
BY
Zheng
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China. xiongxingdong@126.com.|Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China. xiongxingdong@126.com.|Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China. xiongxingdong@126.com.|Department of Pharmacology and the Penn State Hershey Cancer Institute, Milton S. Hershey Medical Center, the Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. xiongxingdong@126.com.
Xing-Dong
XD
Xiong
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D065150:Cellular Reprogramming / Q000235:genetics; D004249:DNA Damage; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism
D062085:RNA, Long Noncoding
diseases; gene regulation; lincRNA-p21; long non-coding RNA