Caloric restriction increases ratio of estrogen to androgen receptors expression in murine ovaries--potential therapeutic implications.
Both estrogens and androgens are involved in the development and normal functioning of the ovaries. It is also known that ovarian function is regulated by diet. The goal of this study was to estimate the expression of sex hormone receptors in ovaries of mice that were on a 9-month caloric restriction (alternate-day feeding) as compared to normal control animals fed ad libitum. We found that prolonged caloric restriction in mouse ovaries led to increased expression of estrogen receptors (ERs) but did not affect expression of the androgen receptor (AR). This increase in ER:AR ration as result of caloric restriction may lead to higher sensitivity to estrogens and upon return to normal diet may increase ovulation. Thus our observation shed more light on a role of beneficial effect of calorie restriction on female reproduction.
Department of Physiology Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland. sylwia@pum.edu.pl.
Sylwia
S
Słuczanowska-Głąbowska
Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, 71-210, Szczecin, Poland. maria@laszczynska.pl.
Maria
M
Laszczyńska
Department of Physiology Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland. piot.kata@gmail.com.
Katarzyna
K
Piotrowska
Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, 71-210, Szczecin, Poland. marta.anna@gmail.pl.
Marta
M
Grabowska
Department of Physiology Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland. katgrymula@o2.pl.
Katarzyna
K
Grymuła
Department of Physiology Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland. mzrata01@louisville.edu.|Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, Ky, USA. mzrata01@louisville.edu.
Mariusz Z
MZ
Ratajczak
D000728:Androgens / Q000235:genetics / Q000378:metabolism; D000818:Animals; D031204:Caloric Restriction; D004195:Disease Models, Animal; D004967:Estrogens / Q000235:genetics / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D010060:Ovulation / Q000235:genetics; D011944:Receptors, Androgen / Q000096:biosynthesis* / Q000235:genetics; D011960:Receptors, Estrogen / Q000096:biosynthesis* / Q000235:genetics; D012098:Reproduction / Q000235:genetics*
C410798:AR protein, human; D000728:Androgens; D004967:Estrogens; D011944:Receptors, Androgen; D011960:Receptors, Estrogen