Pseudo-Guillain-Barré syndrome masking acute myeloid leukemia relapse: Brief report and review.
Central nervous system (CNS) relapse is not a rare presentation in acute myeloid leukemia (AML) as its incidence ranges between 2% and 9%. It manifests with meningeal leukemia, cranial nerve palsies or cerebral mesenchymal myeloid sarcoma. We herein report the case of a 69 year-old female that presented a pseudo-Guillain-Barré syndrome masking an AML CNS relapse. Her symptoms completely resolved upon administration of a tailored treatment. This case suggests that puzzling neurological manifestations in patients with a history of AML should be considered as a CNS recurrence and investigated accordingly even in the context of normal imaging findings.
Hematology-Oncology Department, Hotel Dieu de France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Fadi
F
El Karak
Hematology-Oncology Department, Hotel Dieu de France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Elie
E
El Rassy
Hematology-Oncology Department, Hotel Dieu de France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Samer
S
Tabchi
Unité de Génétique Médicale et Laboratoire Associé INSERM à l'unité UMR_S 910, Pôle Technologie Santé, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Eliane
E
Chouery
Unité de Génétique Médicale et Laboratoire Associé INSERM à l'unité UMR_S 910, Pôle Technologie Santé, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Andre
A
Megarbane
Hematology-Oncology Department, Hotel Dieu de France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Joseph
J
Kattan
Acute myeloid leukemia; Cerebrospinal fluid; Isolated central nervous system recurrence