One-Pot Selective Homodimerization/Hydrogenation Strategy for Sequential Dicarba Bridge Formation.
The installation of interlocked dicarba bridges into peptide sequences requires the development of a regioselective and chemoselective methodology. This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic acid derivatives from an alkyne, a cobalt-carbonyl protected alkyne, and an alkene using metathesis and homogeneous hydrogenation catalysis.
School of Chemistry, Monash University , Clayton, 3800 Victoria, Australia.
James
J
Burnley
School of Chemistry, Monash University , Clayton, 3800 Victoria, Australia.
W Roy
WR
Jackson
School of Chemistry, Monash University , Clayton, 3800 Victoria, Australia.
Andrea J
AJ
Robinson