Efficacy and Safety of Calcipotriol/Betamethasone Dipropionate Ointment for the Treatment of Trachyonychia: An Open-Label Study.
BACKGROUND
Despite efforts to treat trachyonychia, there is no promising treatment modality.


OBJECTIVE
This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia.


METHODS
A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All patients applied calcipotriol/betamethasone ointment once daily without occlusion for 6 months. Outcome measures were assessed by physician's global assessment (degree of roughness: 0, clear; 1, mild; 2, moderate; 3, marked; 4, severe) at all time points.


RESULTS
After 6 months of therapy, 98.6% (426/432) of nails showed significant clinical improvement; 4.2% were completely free from nail lesions. The mean physician global assessment score decreased significantly from 3.5 to 1.7 points (p< 0.05). No serious side effects were reported, except mild pruritus and erythema in 2 patients.


CONCLUSIONS
This is the first study to prospectively evaluate the efficacy and safety of calcipotriol/betamethasone ointment for the treatment of trachyonychia. The results indicate topical calcipotriol/betamethasone is an effective and safe treatment for symptom improvement of trachyonychia.
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
Jung-Min
JM
Park
Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Hyun-Ho
HH
Cho
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
Won-Jeong
WJ
Kim
Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Je-Ho
JH
Mun
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
Margaret
M
Song
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
Hoon-Soo
HS
Kim
Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea. ; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Hyun-Chang
HC
Ko
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Bio-Medical Research Institute, Pusan National University Hospital, Busan, Korea.
Byung-Soo
BS
Kim
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Bio-Medical Research Institute, Pusan National University Hospital, Busan, Korea.
Moon-Bum
MB
Kim
Calcipotriol/betamethasone; Nails; Psoriasis; Topical; Trachyonychia; Treatment