Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST).
Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.
Departments of Orthopaedic Surgery, Hyogo Cancer Center, Kitaouji 13-70, Akashi, Hyogo, 673-0021, Japan. Electronic address: fujitaku@hp.pref.hyogo.jp.
Takuya
T
Fujimoto
Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
Tooru
T
Andoh
Section of Translational Research, Hyogo Cancer Center, Akashi 673-0021, Japan.
Tamotsu
T
Sudo
Departments of Orthopaedic Surgery, Hyogo Cancer Center, Kitaouji 13-70, Akashi, Hyogo, 673-0021, Japan.
Ikuo
I
Fujita
Departments of Orthopaedic Surgery, Hyogo Cancer Center, Kitaouji 13-70, Akashi, Hyogo, 673-0021, Japan.
Naomasa
N
Fukase
Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Tamotsu
T
Takeuchi
Department of Clinical Laboratory, Chugoku Central Hospital, Fukuyama 720-0001, Japan.
Hiroshi
H
Sonobe
Department of General Thoracic Surgery, Osaka University, Graduate School of Medicine, Suita 565-0871, Japan.
Masayoshi
M
Inoue
Department of Diagnostic Pathology, Hyogo Cancer Center, Akashi 673-0021, Japan.
Tkanori
T
Hirose
Department of Diagnostic Pathology, Hyogo Cancer Center, Akashi 673-0021, Japan.
Toshiko
T
Sakuma
Division of Pediatrics, University of Miyazaki, Miyazaki 889-1692, Japan.
Hiroshi
H
Moritake
Department of Pediatrics, Saiseikai Shiga Hospital, Ritto 520-3046, Japan.
Tohru
T
Sugimoto
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Teruya
T
Kawamoto
Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
Yoshinobu
Y
Fukumori
University of Kansas Cancer Center, Kansas, KS 66160, USA.
Satomi
S
Yamamoto
Department of Internal medicine, Kinki-chuo Chest Medical Center, Sakai 591-8025, Japan.
Shinji
S
Atagi
Division of Radiation Life Science, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
Yoshinori
Y
Sakurai
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Masahiro
M
Kurosaka
Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
Koji
K
Ono
Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
Hideki
H
Ichikawa
Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
Minoru
M
Suzuki
D000818:Animals; D001895:Boron / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009442:Neurilemmoma / Q000473:pathology / Q000532:radiotherapy*; D014018:Tissue Distribution
D001895:Boron
Boron neutron capture therapy (BNCT); Clear cell sarcoma; HS-Sch-2; Malignant peripheral nerve sheath tumors (MPNST); NF1; p-Borono-(L)-phenylalanine