The effect of budesonide on orthodontic induced root resorption.
BACKGROUND
The aim of this study was to evaluate the hypothesis that budesonide increases the susceptibility of teeth to root resorption during the course of orthodontic treatment.


METHODS
A randomized controlled trial design (animal study) was employed. Budesonide was administered in test group for 14 days during which orthodontic force was applied to upper right molar. Afterwards, root resorption was measured on mesio-cervical and disto-apical parts of the mesial root on transverse histological sections. ANOVA and Bonfferoni tests were used. Statistical significance was considered to be P ≤ 0.05.


RESULTS
In general, the subgroups in which the force was applied showed significantly greater root resorption. Where force was applied there was no significant difference, whether budesonide was administered or not. While where there was no force, a group who received budesonide showed significantly greater root resorption than the other, unless at the coronal level where the difference was not significant.


CONCLUSIONS
Within the limitations of this study, it seems budesonide could increase root resorption, but in the presence of orthodontic force this effect is negligible.
Department of Orthodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hosseinagha
H
Aghili
Department of Orthodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Amir Reza Fatahi
SA
Meybodi
Department of Oral Pathology, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammed Danesh
MD
Ardekani
Department of Paediatrics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Hassan
MH
Bemanianashkezari
Department of Endodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jalil
J
Modaresi
Department of Oral and Maxillofacial Radiologist, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran.
Yousef
Y
Masomi
Department of Orthodontics, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran.
Mahdjoube Goldani
MG
Moghadam
Budesonide; histomorphomtery; orthodontics; rats; root resorption