Levamisole-Induced Vasculitis with Renal Involvement.
A significant amount of cocaine used in the United States today is adulterated with levamisole. In some instances, prolonged use of contaminated cocaine is associated with the development of levamisole-induced vasculitis (LIV) with features of cutaneous vasculitis and agranulocytosis along with other constitutional symptoms and arthritis. We describe a case of a crack cocaine user with LIV, who developed significant renal disease secondary to crescentic glomerulonephritis, confirmed on renal biopsy. Renal vasculitis is an uncommon feature of LIV and significantly affects clinical course and management.
Karan
K
Chawdhary
Ann
A
Parke
D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000328:Adult; D003042:Cocaine / Q000009:adverse effects; D005260:Female; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D007678:Kidney Glomerulus / Q000473:pathology*; D007978:Levamisole / Q000009:adverse effects*; D016896:Treatment Outcome; D014657:Vasculitis / Q000139:chemically induced* / Q000503:physiopathology
D000276:Adjuvants, Immunologic; D007978:Levamisole; D003042:Cocaine