[Toxic epidermal necrolysis and development of liver abscesses].
Pharmacologic hypersensitivities commonly express cutaneous manifestations, and the highest mortality is found in Stevens Johnson's syndrome and toxic epidermal necrolysis, mostly associated with antibiotics and anticonvulsive drugs. Toxic epidermal necrolysis is related in 80% of cases to pharmacologic hypersensitivity and systemic consequences may be found; hepatic injury has been described, but the finding of liver abscesses has not been reported among common injuries. The case of a patient with a rapid development of multiple liver abscesses in the clinical setting of hypersensitivity due to lamotrigine and the discussion of probable etiologies and management is presented.
Servicio de Medicina Interna, Hospital Regional de Tlalnepantla, ISSEMyM, Edo. de México.
Andrés
A
Domínguez-Borgúa
Servicio de Medicina Interna, Hospital Regional de Tlalnepantla, ISSEMyM, Edo. de México.
Itzel
I
González
Servicio de Medicina Interna, Hospital Regional de Tlalnepantla, ISSEMyM, Edo. de México.
Lucero
L
Morales
Servicio de Medicina Interna, Hospital Regional de Tlalnepantla, ISSEMyM, Edo. de México.
Francisco Manuel
FM
Martínez-Carrillo
Servicio de Medicina Interna, Hospital Regional de Tlalnepantla, ISSEMyM, Edo. de México.
Paul
P
Palacios
D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008100:Liver Abscess / Q000209:etiology*; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000209:etiology*; D014227:Triazines / Q000009:adverse effects*
D014227:Triazines; D000077213:Lamotrigine