Developing from child to adult: Risk factors for poor psychosocial outcome in adolescents and young adults with epilepsy.
BACKGROUND
Childhood-onset epilepsy during the years of transition to adulthood may affect normal social, physical, and mental development, frequently leading to psychosocial and health-related problems in the long term.


OBJECTIVE
This study aimed to describe the main characteristics of patients in transition and to identify risk factors for poor psychosocial outcome in adolescents and young adults with epilepsy.


METHODS
Patients with epilepsy, 15-25years of age, who visited the Kempenhaeghe Epilepsy Transition Clinic from March 2012 to December 2014 were included (n=138). Predefined risk scores for medical, educational/occupational status, and independence/separation/identity were obtained, along with individual risk profile scores for poor psychosocial outcome. Multivariate linear regression analysis and discriminant analysis were used to identify variables associated with an increased risk of poor long-term psychosocial outcome.


RESULTS
Demographic, epilepsy-related, and psychosocial variables associated with a high risk of poor long-term outcome were lower intelligence, higher seizure frequency, ongoing seizures, and an unsupportive and unstable family environment. Using the aforementioned factors in combination, we were able to correctly classify the majority (55.1%) of the patients regarding their risk of poor psychosocial outcome.


CONCLUSIONS
Our analysis may allow early identification of patients at high risk of prevention, preferably at pretransition age. The combination of a chronic refractory epilepsy and an unstable family environment constitutes a higher risk of transition problems and poor outcome in adulthood. As a consequence, early interventions should be put into place to protect youth at risk of poor transition outcome.
Epilepsy Center Kempenhaeghe, Heeze, The Netherlands. Electronic address: GeerlingsR@Kempenhaeghe.nl.
R P J
RP
Geerlings
Epilepsy Center Kempenhaeghe, Heeze, The Netherlands; Faculty of Electrical Engineering, University of Technology, Eindhoven, The Netherlands; Department of Neurology, Maastricht University Hospital, The Netherlands; Department of Neurology, Ghent University Hospital, Belgium. Electronic address: AldenkampB@Kempenhaeghe.nl.
A P
AP
Aldenkamp
Epilepsy Center Kempenhaeghe, Heeze, The Netherlands. Electronic address: GottmerL@Kempenhaeghe.nl.
L M C
LM
Gottmer-Welschen
Faculty of Electrical Engineering, University of Technology, Eindhoven, The Netherlands. Electronic address: P.H.N.de.With@tue.nl.
P H N
PH
de With
Faculty of Electrical Engineering, University of Technology, Eindhoven, The Netherlands. Electronic address: ZingerS@Kempenhaeghe.nl.
S
S
Zinger
Institute of Health Policy & Management, Erasmus University Rotterdam, The Netherlands; Research Centre Innovations in Care, Rotterdam University of Applied Sciences, The Netherlands. Electronic address: a.van.staa@hr.nl.
A L
AL
van Staa
Epilepsy Center Kempenhaeghe, Heeze, The Netherlands; Faculty of Electrical Engineering, University of Technology, Eindhoven, The Netherlands. Electronic address: LouwA@Kempenhaeghe.nl.
A J A
AJ
de Louw
D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D041923:Adolescent Development; D000328:Adult; D002648:Child; D002657:Child Development; D004651:Employment / Q000523:psychology; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D005195:Family Relations / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012944:Social Support; D055815:Young Adult
Epilepsy; Risk factors for transition; Transition clinic; Transition to adult care