Three New Isomeric Indole Alkaloids from Nauclea officinalis.
Three new isomeric monoterpene indole alkaloids, naucleofficines I-III (1-3, resp.) were isolated from the stems (with bark) of Nauclea officinalis. Their structures were elucidated on the basis of spectroscopic methods and single-crystal diffraction analyses. The cytotoxic activities of 1-3 against human colon cancer, human gastric cancer, and human hepatoma cells were also investigated.
Key Laboratory of Rare and Uncommon Diseases, Institute of Materia Medica, Shandong Academy of Medical Sciences, Ji'nan, 250062, Shandong, P. R. China, (phone: +86-531-82919963; fax: +86-531-82919963).
Hai-Yang
HY
Wang
Shandong Academy of Medical Sciences Graduate Education Center, Ji'nan, 250062, Shandong, P. R. China.
Ru-Xia
RX
Wang
Shandong Academy of Medical Sciences Graduate Education Center, Ji'nan, 250062, Shandong, P. R. China.
Yan-Xia
YX
Zhao
Suzhou Reina Pharmaceutical R & D Co., Ltd., Suzhou, 215123, Jiangsu, P. R. China.
Ke
K
Liu
Key Laboratory of Rare and Uncommon Diseases, Institute of Materia Medica, Shandong Academy of Medical Sciences, Ji'nan, 250062, Shandong, P. R. China, (phone: +86-531-82919963; fax: +86-531-82919963).
Feng-Ling
FL
Wang
Key Laboratory of Rare and Uncommon Diseases, Institute of Materia Medica, Shandong Academy of Medical Sciences, Ji'nan, 250062, Shandong, P. R. China, (phone: +86-531-82919963; fax: +86-531-82919963). sunjingyong08@hotmail.com.
Jing-Yong
JY
Sun
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D018547:Plant Stems / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids
Cytotoxic activity; Monoterpene indole alkaloids; Nauclea officinalis; Naucleofficines I - III