Safety and Efficacy of Staged Percutaneous Coronary Intervention During Index Admission for ST-Elevation Myocardial Infarction With Multivessel Coronary Disease (Insights from the University of Ottawa Heart Institute STEMI Registry).
The optimal management strategy for patients with ST-elevation myocardial infarction (STEMI) and multivessel disease has not been well established. In the present cohort study, we sought to examine the safety and efficacy of inhospital staged PCI for patients with STEMI and multivessel disease. We identified all patients with STEMI referred for primary PCI who were found to have multivessel disease (stenosis ≥50% in nonculprit vessel) and compared clinical outcomes in relation to the management strategy, staged versus culprit-only PCI, for nonculprit vessel disease. The primary outcome was mortality at 180 days, and secondary outcomes included mortality during the index hospitalization and at 30 days, myocardial infarction, stent thrombosis, stroke, and bleeding. Of the 1,038 patients with STEMI meeting inclusion criteria, 259 (25%) underwent staged PCI and 779 (75%) culprit-only PCI during the index admission. Mortality at 180 days was 0.8% in patients with staged PCI and 5.0% in patients with culprit-only PCI (p = 0.003). The association between staged PCI and reduced mortality persisted after adjusting for baseline differences in patient characteristics and angiographic variables between the 2 cohorts (odds ratio 0.2, 95% confidence interval 0.04 to 0.77, p = 0.02). The rates of inhospital reinfarction in the staged and culprit-only PCI cohorts were 0.8% versus 1.3% (p = 0.50), respectively, stent thrombosis 0.8% versus 1.3% (p = 0.50), and stroke 0.4% versus 1.3% (p = 0.31). There were no inhospital adverse events related to acute occlusion of a nonculprit vessel in either cohort. Staged PCI during index admission is a safe and effective revascularization strategy for patients with STEMI and multivessel disease.
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Juan J
JJ
Russo
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
George A
GA
Wells
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Aun Yeong
AY
Chong
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Derek Y
DY
So
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Chris A
CA
Glover
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Michael P V
MP
Froeschl
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Benjamin
B
Hibbert
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Jean-François
JF
Marquis
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Alexander
A
Dick
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Melissa
M
Blondeau
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Jordan
J
Bernick
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Marino
M
Labinaz
Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address: mlemay@ottawaheart.ca.
Michel R
MR
Le May
D000368:Aged; D002170:Canada; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D004562:Electrocardiography; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D062645:Percutaneous Coronary Intervention; D012042:Registries; D016896:Treatment Outcome