Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives.
In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents.
College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. wangdd@nwsuaf.edu.cn.
Dongdong
D
Wang
College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. wuxia@nwsuaf.edu.cn.
Wuxia
W
Zhang
College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. 2013051706@nwsuaf.edu.cn.
Tingting
T
Wang
College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. 2009010186@nwsuaf.edu.cn.
Na
N
Li
College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. sdnw2528@sina.com.
Haibo
H
Mu
College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. nwzjw@163.com.
Jiwen
J
Zhang
College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. jduan@nwsuaf.edu.cn.
Jinyou
J
Duan
D045784:Abietanes / Q000138:chemical synthesis / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D017665:Hydroxyl Radical / Q000737:chemistry; D008826:Microbial Sensitivity Tests
D045784:Abietanes; D000900:Anti-Bacterial Agents; C021751:tanshinone; D017665:Hydroxyl Radical
antibacterial; membrane; pyrrolidine; reactive oxygen species (ROS); tanshinone