Influences of Different Doses of Midazolam on Mother and Fetus in Fetoscopic Surgery for Twin-to-Twin Transfusion Syndrome.
OBJECTIVE
We observed influences of different doses of intravenous midazolam on mother and fetus in fetoscopic surgery for twin-to-twin transfusion syndrome (TTTS).


METHODS
A total of 18 pregnant women with TTTS were randomly divided into groups M1 and M2 according to differing doses of midazolam. Some parameters were respectively recorded as prior to administration of midazolam (T0), instantly after anesthesia induction (T1), at incision (T2), instantly after laser coagulation (T3) and at the end of surgery (T4).


RESULTS
There was no statistical difference in oxygen saturation and respiratory rate between groups M1 and M2 (all p > 0.05); but mean arterial pressure, heart rate, anxiety visual analog test, Observer's Assessment of Alertness/Sedation scale values and Kreb's scores were significantly lower in group M2 than in group M1 from T1 to T4 (all p < 0.05). In both groups, there was no fetal movement during laser coagulation.


CONCLUSIONS
We propose that the appropriate dose for midazolam be 0.02 mg/kg in fetoscopic surgery for TTTS.
Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, China.
Guang
G
Han
Lu
L
Li
Yue
Y
Tian
Hang
H
Xue
Ping
P
Zhao
D000328:Adult; D000773:Anesthesia, Obstetrical; D001007:Anxiety / Q000523:psychology; D005260:Female; D005323:Fetal Monitoring; D005330:Fetofetal Transfusion / Q000601:surgery*; D005332:Fetoscopy / Q000379:methods*; D005333:Fetus / Q000187:drug effects* / Q000601:surgery*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D017075:Laser Coagulation; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D056152:Respiratory Rate / Q000187:drug effects
D006993:Hypnotics and Sedatives; D008874:Midazolam; D010100:Oxygen