Risk factors for celiac disease.
Celiac Disease (CD) is an immune-mediated systemic disorder elicited by gluten and related prolamines in genetically susceptible individuals and it is the result of the interaction between genetic and environmental factors. Among genetic risk factors, the strongest association is with the HLA class II DQ region; nevertheless at least 39 non-HLA loci are associated with CD. Gluten is the main environmental trigger of the disease. In addition, infant feeding and weaning practices as well as timing of gluten introduction in the diet have been suggested to contribute to CD risk. Furthermore a role for infectious agents and microbiota composition in disease development has also been proposed.Aim of this short review is to discuss the current knowledge on both genetic and environmental risk factors for the development of CD; moreover we will provide a brief overview of the possible strategies that could be envisaged to prevent this condition, at least in the population at-risk.
Department of Translational Medical Science, Section of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases (ELFID), University of Naples Federico II, via S Pansini 5, 80131, Naples, Italy. marc.sarno4@gmail.com.
Marco
M
Sarno
Department of Translational Medical Science, Section of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases (ELFID), University of Naples Federico II, via S Pansini 5, 80131, Naples, Italy. vale.discepolo@gmail.com.
Valentina
V
Discepolo
Department of Translational Medical Science, Section of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases (ELFID), University of Naples Federico II, via S Pansini 5, 80131, Naples, Italy. troncone@unina.it.
Riccardo
R
Troncone
Department of Translational Medical Science, Section of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases (ELFID), University of Naples Federico II, via S Pansini 5, 80131, Naples, Italy. r.auricchio@unina.it.
Renata
R
Auricchio
D002446:Celiac Disease / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control*; D020022:Genetic Predisposition to Disease; D006801:Humans; D054892:Metagenome / Q000276:immunology; D064307:Microbiota / Q000276:immunology; D012307:Risk Factors