Relationship between antidepressant prescription and breast cancer: a population based study in Taiwan.
To investigate the association between antidepressant prescription and breast cancer.



The National Health Research Institute in Taiwan provided a database of 1 000 000 random subjects for this study. We identified 14 737 new antidepressant female users who were more than 15 years old during 1999-2005 with at least 10 prescriptions and one year exposure to an antidepressant. These were matched 1:1 by age and residence to non-antidepressant users from the same database to compare the risk of breast cancer.



In a model adjusted by age, residence, insurance amount, and depressive disorder, antidepressant prescription was not associated with breast cancer risk. This held true for both selective serotonin re-uptake inhibitors (SSRIs) and tricyclic antidepressants.



There was no evidence for an association between antidepressant prescription and the risk of breast cancer. Copyright © 2015 John Wiley & Sons, Ltd.
Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.|School of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Chang Gung University, Taiwan.|Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Taiwan.
Vincent Chin-Hung
VC
Chen
Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.|School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Yin-To
YT
Liao
Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
Dah-Cherng
DC
Yeh
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Hsien-Chun
HC
Tseng
King's College London, Institute of Psychiatry, London, UK.
Robert
R
Stewart
Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
Charles Tzu-Chi
CT
Lee
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D015897:Comorbidity; D003866:Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012107:Research Design; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic