Elucidating the Structure of Chiral Molecules by using Amplified Vibrational Circular Dichroism: From Theory to Experimental Realization.
Recent experimental observations of enhanced vibrational circular dichroism (VCD) in molecular systems with low-lying electronically excited states suggest interesting new applications of VCD spectroscopy. The theory describing VCD enhancement through vibronic coupling schemes was derived by Nafie in 1983, but only recently experimental evidence of VCD amplification has demonstrated the extent to which this effect can be exploited as a structure elucidation tool to probe local structure. In this Concept paper, we give an overview of the physics behind vibrational circular dichroism, in particular the equations governing the VCD amplification effect, and review the latest experimental developments with a prospective view on the application of amplified VCD to locally probe biomolecular structure.
Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.|Max Planck Institute for the Structure and Dynamics of Matter at the Center for Free-Electron Laser Science, The Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22671, Hamburg, Germany.
Sérgio R
SR
Domingos
Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, United Kingdom. f.hartl@reading.ac.uk.
František
F
Hartl
Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands. w.j.buma@uva.nl.
Wybren Jan
WJ
Buma
Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands. s.woutersen@uva.nl.
Sander
S
Woutersen
D000818:Animals; D002712:Chlorides / Q000737:chemistry; D002942:Circular Dichroism; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry; D004583:Electrons; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D008962:Models, Theoretical; D009532:Nickel / Q000737:chemistry; D013237:Stereoisomerism; D017967:Zinc Compounds / Q000737:chemistry
D002712:Chlorides; D056831:Coordination Complexes; D006454:Hemoglobins; D017967:Zinc Compounds; D003035:Cobalt; C022838:nickel chloride; D009532:Nickel; C016837:zinc chloride; C018021:cobaltous chloride
biomolecules; chirality; circular dichroism; local amplification; structure elucidation