Changes in functional MRI signals after 3D based radiotherapy of glioblastoma multiforme.
The purpose of our study was to examine the potential effects of conventional 3D based radiotherapy on functional MRI activation areas following the treatment of glioblastoma multiforme. Seventeen patients with a histologically proven glioblastoma multiforme were enrolled in this study. A functional MRI examination was performed alongside the planning CT and conventional MRI prior to the delivery of conventional 3D based radiotherapy. All patients received 3D based postoperative radiotherapy (up to 60 Gy) combined with temozolomide. Follow-up fMRI examinations were performed after completion of the treatment in the 6th week and in 3 months time. Changes of the task related activation areas were registered and analyzed. The difference in changes of high dose and low dose areas of the brain were also registered and analyzed. The comparison of the pretreatment and 6th week control fMRI activation areas revealed significant changes in motor activation and listening tasks in the case of brain areas which received a high dose (over 40 Gy). Based on the population level statistical parametric images (motor activation tasks) acquired at the 6th week control examination, a significant increase of signal was registered in the precuneus region and in the globus pallidus region. When comparing the 6th week and 3rd month activation signals, no significant changes were registered. Our results demonstrate the influence of radiotherapy on functional MRI signals within the human brain. Based on our findings, functional activation transfers from high dose areas to low dose areas. In case of the motor activation tasks, activations of the secondary motor area were observed following radiotherapy.
Department of Diagnostics and Oncoradiology, University of Kaposvár, Guba S. Street 40, Kaposvar, 7400, Hungary. kovacs.arpad1979@gmail.com.|Faculty of Health Science, University of Pécs, Pécs, Hungary. kovacs.arpad1979@gmail.com.
Árpád
Á
Kovács
Department of Nuclear Medicine, University of Debrecen, Debrecen, Hungary.
Miklós
M
Emri
Department of Nuclear Medicine, University of Debrecen, Debrecen, Hungary.
Gábor
G
Opposits
Department of Nuclear Medicine, University of Debrecen, Debrecen, Hungary.
Tamás
T
Pisák
Department of Diagnostics and Oncoradiology, University of Kaposvár, Guba S. Street 40, Kaposvar, 7400, Hungary.
Csaba
C
Vandulek
Department of Diagnostics and Oncoradiology, University of Kaposvár, Guba S. Street 40, Kaposvar, 7400, Hungary.
Csaba
C
Glavák
Department of Diagnostics and Oncoradiology, University of Kaposvár, Guba S. Street 40, Kaposvar, 7400, Hungary.
Zoltán
Z
Szalai
Department of Diagnostics and Oncoradiology, University of Kaposvár, Guba S. Street 40, Kaposvar, 7400, Hungary.
Gergely
G
Biró
Department of Diagnostics and Oncoradiology, University of Kaposvár, Guba S. Street 40, Kaposvar, 7400, Hungary.
Gábor
G
Bajzik
Department of Diagnostics and Oncoradiology, University of Kaposvár, Guba S. Street 40, Kaposvar, 7400, Hungary.
Imre
I
Repa
D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply* / Q000528:radiation effects; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D005260:Female; D007839:Functional Laterality; D005909:Glioblastoma / Q000473:pathology* / Q000532:radiotherapy*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010100:Oxygen / Q000097:blood; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D010100:Oxygen
Radiotherapy; Signal changes; fMRI