Facile Enzymatic Synthesis of Ketoses.
Studies of rare ketoses have been hampered by a lack of efficient preparation methods. A convenient, efficient, and cost-effective platform for the facile synthesis of ketoses is described. This method enables the preparation of difficult-to-access ketopentoses and ketohexoses from common and inexpensive starting materials with high yield and purity and without the need for a tedious isomer separation step.
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).
Liuqing
L
Wen
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).
Kenneth
K
Huang
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).
Mohui
M
Wei
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).|Current Address: Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322 (USA).
Jeffrey
J
Meisner
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).
Yunpeng
Y
Liu
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).
Kristina
K
Garner
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).
Lanlan
L
Zang
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).
Xuan
X
Wang
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA).
Xu
X
Li
National Glycoengineering Research Center, Shandong University, Jinan 250100 (China).
Junqiang
J
Fang
National Glycoengineering Research Center, Shandong University, Jinan 250100 (China).
Houcheng
H
Zhang
Department of Chemistry and Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303 (USA). pwang11@gsu.edu.|National Glycoengineering Research Center, Shandong University, Jinan 250100 (China). pwang11@gsu.edu.
Peng George
PG
Wang
D055162:Biocatalysis; D060326:Chemistry Techniques, Synthetic / Q000191:economics / Q000379:methods; D005631:Fructokinases / Q000378:metabolism; D006801:Humans; D007536:Isomerism; D007661:Ketoses / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism; D014176:Protein Biosynthesis; D020124:Thermotoga maritima / Q000201:enzymology
D007661:Ketoses; D005631:Fructokinases; D017853:Phosphotransferases (Alcohol Group Acceptor); C062877:rhamnulokinase
enzymatic synthesis; ketoses; one-pot reactions; phosphorylation; synthetic methods