[The biological functions and regulations of competing endogenous RNA].
Recent studies demonstrate that RNA species could regulate each other by competing for shared microRNA response elements (MREs). This regulatory model is called competing endogenous RNA (ceRNA). Currently, the identified ceRNAs cover coding and non-coding RNAs. The latter includes pseudogene transcripts, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and so on. In this review, we summarize the biological functions of regulatory networks consisting of various types of ceRNAs and their roles in the pathological and physiological processes. Additionally, several factors that may regulate ceRNAs were discussed.
1. Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China; 2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China;
Jing-qiu
JQ
Li
1. Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China; 2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China;
Jie
J
Yang
1. Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China; 2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China;
Ping
P
Zhou
1. Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China; 2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China;
Yan-ping
YP
Le
1. Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China; 2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China;
Zhao-hui
ZH
Gong
D000818:Animals; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D011544:Pseudogenes / Q000502:physiology*; D012313:RNA / Q000502:physiology*; D000079962:RNA, Circular; D062085:RNA, Long Noncoding / Q000502:physiology*; D012333:RNA, Messenger / Q000502:physiology
D035683:MicroRNAs; D000079962:RNA, Circular; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D012313:RNA