Allocation of patients with liver cirrhosis and organ failure to intensive care: Systematic review and a proposal for clinical practice.
OBJECTIVE
To propose an allocation system of patients with liver cirrhosis to intensive care unit (ICU), and developed a decision tool for clinical practice.


METHODS
A systematic review of the literature was performed in PubMed, MEDLINE and EMBASE databases. The search includes studies on hospitalized patients with cirrhosis and organ failure, or acute on chronic liver failure and/or intensive care therapy.


RESULTS
The initial search identified 660 potentially relevant articles. Ultimately, five articles were selected; two cohort studies and three reviews were found eligible. The literature on this topic is scarce and no studies specifically address allocation of patients with liver cirrhosis to ICU. Throughout the literature, there is consensus that selection criteria for ICU admission should be developed and validated for this group of patients and multidisciplinary approach is mandatory. Based on current available data we developed an algorithm, to determine if a patient is candidate to intensive care if needed, based on three scoring systems: premorbid Child-Pugh Score, Model of End stage Liver Disease score and the liver specific Sequential Organ Failure Assessment score.


CONCLUSIONS
There are no established systems for allocation of patients with liver cirrhosis to the ICU and no evidence-based recommendations can be made.
Katrine Prier Lindvig, Ane Søgaard Teisner, Jens Kjeldsen, Aleksander Krag, Department of Gastroenterology and Hepatology, Odense University Hospital, 5000 Odense, Denmark.
Katrine Prier
KP
Lindvig
Katrine Prier Lindvig, Ane Søgaard Teisner, Jens Kjeldsen, Aleksander Krag, Department of Gastroenterology and Hepatology, Odense University Hospital, 5000 Odense, Denmark.
Ane Søgaard
AS
Teisner
Katrine Prier Lindvig, Ane Søgaard Teisner, Jens Kjeldsen, Aleksander Krag, Department of Gastroenterology and Hepatology, Odense University Hospital, 5000 Odense, Denmark.
Jens
J
Kjeldsen
Katrine Prier Lindvig, Ane Søgaard Teisner, Jens Kjeldsen, Aleksander Krag, Department of Gastroenterology and Hepatology, Odense University Hospital, 5000 Odense, Denmark.
Thomas
T
Strøm
Katrine Prier Lindvig, Ane Søgaard Teisner, Jens Kjeldsen, Aleksander Krag, Department of Gastroenterology and Hepatology, Odense University Hospital, 5000 Odense, Denmark.
Palle
P
Toft
Katrine Prier Lindvig, Ane Søgaard Teisner, Jens Kjeldsen, Aleksander Krag, Department of Gastroenterology and Hepatology, Odense University Hospital, 5000 Odense, Denmark.
Valentin
V
Furhmann
Katrine Prier Lindvig, Ane Søgaard Teisner, Jens Kjeldsen, Aleksander Krag, Department of Gastroenterology and Hepatology, Odense University Hospital, 5000 Odense, Denmark.
Aleksander
A
Krag
D018806:APACHE; D065290:Acute-On-Chronic Liver Failure / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D003422:Critical Care; D020000:Decision Support Systems, Clinical; D003661:Decision Support Techniques; D015276:Health Care Rationing; D006801:Humans; D007362:Intensive Care Units; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D063305:Organ Dysfunction Scores; D018579:Patient Selection; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
Allocation; Cirrhosis; Failure; Intensive care; Treatment