A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions.
Goal-directed behavior is often impaired by interference from the external environment, either in the form of distraction by irrelevant information that one attempts to ignore, or by interrupting information that demands attention as part of another (secondary) task goal. Both forms of external interference have been shown to detrimentally impact the ability to maintain information in working memory (WM). Emerging evidence suggests that these different types of external interference exert different effects on behavior and may be mediated by distinct neural mechanisms. Better characterizing the distinct neuro-behavioral impact of irrelevant distractions versus attended interruptions is essential for advancing an understanding of top-down attention, resolution of external interference, and how these abilities become degraded in healthy aging and in neuropsychiatric conditions. This manuscript describes a novel cognitive paradigm developed the Gazzaley lab that has now been modified into several distinct versions used to elucidate behavioral and neural correlates of interference, by to-be-ignored distractors versus to-be-attended interruptors. Details are provided on variants of this paradigm for investigating interference in visual and auditory modalities, at multiple levels of stimulus complexity, and with experimental timing optimized for electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) studies. In addition, data from younger and older adult participants obtained using this paradigm is reviewed and discussed in the context of its relationship with the broader literatures on external interference and age-related neuro-behavioral changes in resolving interference in working memory.
Department of Psychology, University of New Mexico; jackijanowich@gmail.com.
Jacki
J
Janowich
Department of Neurology, University of California, San Francisco.
Jyoti
J
Mishra
Department of Neurology, University of California, San Francisco; Department of Physiology, Center for Integrative Neuroscience, University of California, San Francisco; Department of Psychiatry, University of California, San Francisco.
Adam
A
Gazzaley
D000328:Adult; D000367:Age Factors; D000368:Aged; D001288:Attention / Q000502:physiology*; D001519:Behavior / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult