Dectin-1 Exerts Dual Control in the Gut.
Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut.
F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address: Iliyan.Iliev@cshs.org.
Iliyan D
ID
Iliev
D000818:Animals; D003092:Colitis / Q000473:pathology*; D003106:Colon / Q000276:immunology* / Q000473:pathology*; D007778:Lactobacillus / Q000276:immunology*; D037181:Lectins, C-Type / Q000037:antagonists & inhibitors*; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D037181:Lectins, C-Type