Sister chromatid decatenation: bridging the gaps in our knowledge.
Faithful chromosome segregation is critical in preventing genome loss or damage during cell division. Failure to properly disentangle catenated sister chromatids can lead to the formation of bulky or ultrafine anaphase bridges, and ultimately genome instability. In this review we present an overview of the current state of knowledge of how sister chromatid decatenation is carried out, with particular focus on the role of TOP2A and TOPBP1 in this process.
a Department of Oncology ; Weatherall Institute of Molecular Medicine; University of Oxford ; Oxford , UK.
Ronan
R
Broderick
a Department of Oncology ; Weatherall Institute of Molecular Medicine; University of Oxford ; Oxford , UK.
Wojciech
W
Niedzwiedz
D000705:Anaphase / Q000235:genetics / Q000502:physiology; D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D002842:Chromatids / Q000378:metabolism*; D020090:Chromosome Segregation / Q000235:genetics / Q000502:physiology; D004250:DNA Topoisomerases, Type II / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008938:Mitosis / Q000235:genetics / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D000075223:Poly-ADP-Ribose Binding Proteins
D000951:Antigens, Neoplasm; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; C110513:TOPBP1 protein, human; D004250:DNA Topoisomerases, Type II; C000618811:TOP2A protein, human
anaphase bridges, mitosis, sister chromatid decatenation, TOP2A, TOPBP1, UFB