Inherited anomalies of innate immune receptors in pediatric-onset inflammatory diseases.
Pattern-recognition receptors (PRRs) can detect various pathogen-associated molecular patterns such as carbohydrates, nucleic acids or bacterial peptides and play a major role in both innate and adaptive immunity. In physiological conditions, the engagement of PRRs triggers the production of proinflammatory cytokines and promotes pathogen destruction. Inappropriate stimulation or defective regulation of PRR has been recently evidenced in several inherited inflammatory disorders. This new field of childhood-onset inflammatory diseases encompass the so-called type-I interferon-related diseases and autoinflammatory diseases.
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; Inserm U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; CNRS, UMR5308, Lyon, France; Department of Pathology, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, CHU de Lyon, France; Claude Bernard Lyon 1 University, Lyon, France.
Cécile
C
Picard
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; Inserm U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; CNRS, UMR5308, Lyon, France.
Anne-Laure
AL
Mathieu
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; Inserm U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; CNRS, UMR5308, Lyon, France.
Uzma
U
Hasan
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; Inserm U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; CNRS, UMR5308, Lyon, France.
Thomas
T
Henry
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; Inserm U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; CNRS, UMR5308, Lyon, France; Internal Medicine Department, Hôpital de la Croix Rousse, Hospices Civils de Lyon, CHU de Lyon, France.
Yvan
Y
Jamilloux
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; Inserm U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; CNRS, UMR5308, Lyon, France.
Thierry
T
Walzer
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; Inserm U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; CNRS, UMR5308, Lyon, France; Claude Bernard Lyon 1 University, Lyon, France; (h)Pediatric Rheumatology, Nephrology and Dermatology Department, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, CHU de Lyon, France. Electronic address: alexandre.belot@chu-lyon.fr.
Alexandre
A
Belot
D017668:Age of Onset; D001327:Autoimmune Diseases; D002648:Child; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
D051192:Receptors, Pattern Recognition
Autoimmune diseases; Autoinflammatory diseases; Children; Cytokines; Genetics; Interferonopathies; Pathogen recognition receptors