[THE ROLE OF OXIDATIVE STRESS IN THE PATHOGENESIS OF GASTROESOPHAGEAL REFLUX DISEASE].
OBJECTIVE
To study features of lipid peroxidation in patients with different types of gastroesophageal reflux disease (GERD).


METHODS
We examined 120 patients with different clinical variants of GERD and 25 healthy individuals. It was determined the concentration of diene conjugates (DC) ketodienes (KD), conjugated trienes (CT) by biochemical methods in serum and mucosal biopsies of the lower third of the esophagus.


RESULTS
In biopsies of esophagus mucosa the content of DK, CD, CT was increased in patients with complications of GERD (ulcerative esophagitis and Barrett's esophagus) in 2,2-5,3 times compared with healthy individuals. In blood serum registered similar but less pronounced regularities.


CONCLUSIONS
It was revealed a significant intensification of free radical oxidation in the tissues of the esophagus and the blood of patients with GERD, which was exacerbated in proportion to the severity of the disease.
N N
NN
Butorin
T B
TB
Bichurina
A V
AV
Vasyutin
M E
ME
Solodyonova
E V
EV
Onuchina
J L
JL
Tonkikh
V V
VV
Tsukanov
D004947:Esophagus / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D012720:Severity of Illness Index