The effect of iterative model reconstruction on coronary artery calcium quantification.
Coronary artery calcium (CAC) scoring with computed tomography (CT) is an established tool for quantifying calcified atherosclerotic plaque burden. Despite the widespread use of novel image reconstruction techniques in CT, the effect of iterative model reconstruction on CAC score remains unclear. We sought to assess the impact of iterative model based reconstruction (IMR) on coronary artery calcium quantification as compared to the standard filtered back projection (FBP) algorithm and hybrid iterative reconstruction (HIR). In addition, we aimed to simulate the impact of iterative reconstruction techniques on calcium scoring based risk stratification of a larger asymptomatic population. We studied 63 individuals who underwent CAC scoring. Images were reconstructed with FBP, HIR and IMR and CAC scores were measured. We estimated the cardiovascular risk reclassification rate of IMR versus HIR and FBP in a larger asymptomatic population (n = 504). The median CAC scores were 147.7 (IQR 9.6-582.9), 107.0 (IQR 5.9-526.6) and 115.1 (IQR 9.3-508.3) for FBP, HIR and IMR, respectively. The HIR and IMR resulted in lower CAC scores as compared to FBP (both p < 0.001), however there was no difference between HIR and IMR (p = 0.855). The CAC score decreased by 7.2 % in HIR and 7.3 % in IMR as compared to FBP, resulting in a risk reclassification rate of 2.4 % for both HIR and IMR. The utilization of IMR for CAC scoring reduces the measured calcium quantity. However, the CAC score based risk stratification demonstrated modest reclassification in IMR and HIR versus FBP.
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Bálint
B
Szilveszter
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Hesham
H
Elzomor
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Mihály
M
Károlyi
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Márton
M
Kolossváry
Philips HealthTech, Veenpluis 4-6, 5684 PC, Best, The Netherlands.
Rolf
R
Raaijmakers
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Kálmán
K
Benke
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Csilla
C
Celeng
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Andrea
A
Bartykowszki
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Zsolt
Z
Bagyura
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Árpád
Á
Lux
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary.
Béla
B
Merkely
MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor ut, Budapest, 1122, Hungary. p.maurovich-horvat@cirg.hu.
Pál
P
Maurovich-Horvat
D000368:Aged; D000465:Algorithms; D003198:Computer Simulation; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011379:Prognosis; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D061205:Vascular Calcification / Q000000981:diagnostic imaging*
Computed tomography; Coronary artery calcium scoring; Coronary artery disease; Iterative model reconstruction; Risk stratification