In vitro degradation of pure Mg in response to glucose.
Magnesium and its alloys are promising biodegradable biomaterials but are still challenging to be used in person with high levels of blood glucose or diabetes. To date, the influence of glucose on magnesium degradation has not yet been elucidated, this issue requires more attention. Herein, we present pure Mg exhibiting different corrosion responses to saline and Hank's solutions with different glucose contents, and the degradation mechanism of pure Mg in the saline solution with glucose in comparison with mannitol as a control. On one hand, the corrosion rate of pure Mg increases with the glucose concentration in saline solutions. Glucose rapidly transforms into gluconic acid, which attacks the oxides of the metal and decreases the pH of the solution; it also promotes the absorption of chloride ions on the Mg surface and consequently accelerates corrosion. On the other hand, better corrosion resistance is obtained with increasing glucose content in Hank's solution due to the fact that glucose coordinates Ca(2+) ions in Hank's solution and thus improves the formation of Ca-P compounds on the pure Mg surface. This finding will open up new avenues for research on the biodegradation of bio-Mg materials in general, which could yield many new and interesting results.
1] College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China [2] State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China.
Rong-Chang
RC
Zeng
1] College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China [2] State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China.
Xiao-Ting
XT
Li
1] College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China [2] State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China.
Shuo-Qi
SQ
Li
1] College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China [2] State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China.
Fen
F
Zhang
National Engineering Center for Corrosion Control, Institute of Metals Research, Chinese Academy of Sciences, Shenyang 110016, China.
En-Hou
EH
Han
D003343:Corrosion; D005947:Glucose / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008274:Magnesium / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D009994:Osmolar Concentration; D014961:X-Ray Diffraction
D008274:Magnesium; D005947:Glucose