Epithelial Dysplasia in Ameloblastic Fibrosarcoma Arising from Recurrent Ameloblastic Fibroma in a 26-Year-Old Iranian Man.
BACKGROUND Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor with a mesenchymal component, showing sarcomatous features and epithelial nests resembling ameloblastic fibroma (AF). CASE REPORT We report a case of AFS showing epithelial dysplasia arising in a recurrent AF in the left mandible after 3 years in a 26-year-old man, which is regarded as an uncommon histopathologic finding in AFS. We also emphasize the comprehensive clinical, radiographic, and histopathologic evaluation, and immunohistochemical staining of this patient. CONCLUSIONS We conclude that it is important to consider malignancy alternations in the epithelial component of AFS, along with that of the mesenchymal component, to provide a proper diagnosis and treatment of recurrent AF.
Department of Pathology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zhaleh
Z
Mohsenifar
Department of Oral and Maxillofacial Pathology, Shahid Beheshti, Dental School, Tehran, Iran.
Samira
S
Behrad
Department of Oral and Maxillofacial Pathology, Shahid Beheshti, Dental School, Tehran, Iran.
Fatemeh Mashhadi
FM
Abbas
D000328:Adult; D005350:Fibroma / Q000473:pathology* / Q000601:surgery; D005354:Fibrosarcoma / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007492:Iran; D008297:Male; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000601:surgery; D009808:Odontogenic Tumors / Q000175:diagnosis* / Q000601:surgery