Rh(III)-catalyzed cyclization reaction of azoles with alkynes: efficient synthesis of azole-fused-pyridines.
A Rh(iii)-catalyzed cyclization of azoles with alkynes has been developed. A variety of azole-fused-pyridines were obtained in good to excellent yields and regioselectivity. Both the C5 and the C4 position of azoles were suitable for the reaction.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 24 Tong Jia Xiang, 210009, P. R. China.
Xuebing
X
Chen
Youzhi
Y
Wu
Jinyi
J
Xu
Hequan
H
Yao
Aijun
A
Lin
Yue
Y
Huang
D000480:Alkynes / Q000737:chemistry*; D001393:Azoles / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
D000480:Alkynes; D001393:Azoles; D011725:Pyridines; D012238:Rhodium