The management of cytotoxic chemotherapy extravasation: a systematic review of the literature to evaluate the evidence underpinning contemporary practice.
Management of cytotoxic drug extravasation remains contentious, with differing views on the most effective management strategy. With the increasing drive to provide effective, evidence-based healthcare, while ensuring the patient experience of the treatment provided plays a significant part in the development of clinical practice guidelines, the purpose of this literature review was to both critically analyse the quality of evidence that underpins contemporary practice and to determine if the patient experience is taken into account. A literature search was undertaken sourcing publications from the 1960s to July 2014 identifying all studies detailing strategies aimed at preventing the need for surgical debridement and all studies evaluating extravasation management from the patient's perspective. No conclusive evidence was found to suggest one clinical strategy as more effective than the other. No studies were identified that evaluated outcome from the patient's perspective. It is therefore suggested that outcomes-based research should underpin contemporary extravasation management guidelines to determine what the final outcome or 'end result' is and how this impacts on the patient and that the current lack of research into the patient experience of extravasation management is an area that needs to be addressed.
Chemotherapy Unit, Mount Vernon Cancer Centre, Northwood, UK.
K
K
Harrold
Cardiff School of Healthcare Sciences, Cardiff Univeristy, Cardiff, UK.
D
D
Gould
School of Health Sciences, City University, London, UK.
N
N
Drey
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000628:therapy*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D007507:Therapeutic Irrigation / Q000379:methods*
D000931:Antidotes; D000970:Antineoplastic Agents
antidotes; chemotherapy; extravasation; management; patient experience; saline washout