Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study.
OBJECTIVE
Electronic cigarettes are growing in popularity, but the physiological consequences of vaporized nicotine are unknown.


METHODS
Twenty healthy non-smokers inhaled vaporized nicotine and placebo (randomized).


RESULTS
Nicotine inhalation was associated with higher arterial pressures in the seated position, and increased arterial pressures in the head-up positions with no other effects on autonomic control.


CONCLUSIONS
Our results show that vaporized nicotine inhalation is not innocuous. Longitudinal studies in otherwise healthy non-smokers should be conducted.
Department of Kinesiology, Health, and Nutrition, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA. william.cooke@utsa.edu.
William H
WH
Cooke
Department of Kinesiology, Health, and Nutrition, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Anusheela
A
Pokhrel
Department of Kinesiology, Health, and Nutrition, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Colin
C
Dowling
Department of Kinesiology, Health, and Nutrition, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Donovan L
DL
Fogt
Department of Integrative Physiology and Anatomy, The University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Caroline A
CA
Rickards
D000280:Administration, Inhalation; D062186:Arterial Pressure / Q000187:drug effects* / Q000502:physiology; D066300:Electronic Nicotine Delivery Systems / Q000009:adverse effects* / Q000639:trends; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D009538:Nicotine / Q000008:administration & dosage*; D010865:Pilot Projects; D018667:Tilt-Table Test / Q000379:methods; D014835:Volatilization; D055815:Young Adult
D009538:Nicotine
Autonomic control; Blood pressure; Electronic cigarettes; Head-up tilt