RELATIONSHIPS AMONG THYROID HORMONES AND OBESITY SEVERITY, METABOLIC SYNDROME AND ITS COMPONENTS IN TURKISH CHILDREN WITH OBESITY.
BACKGROUND
we investigated the relationships between thyroid function and obesity severity, metabolic syndrome (MS) and MS components in 260 obese children and adolescents 10-17 years of age.


OBJECTIVE
we aimed to determine the association of thyroid functions with obesity severity and the components of metabolic syndrome (MS) in pediatric obese patients.


METHODS
only obese children and adolescents were included, and divided the obese children into three groups according to body mass index (BMI)-SDS quartiles. The first quartile was group 1, the second and third quartiles were group 2, and the fourth quartile was group 3. Group 3 indicated severe obesity. The modified WHO criteria adapted for children were used to diagnose MS. We assessed anthropometric data and serum biochemical parameters, including the lipid profile and fasting glucose (FG), insulin, thyroid-stimulating hormone (TSH), free thyroxine (fT4), and free triiodothyronine (fT3) levels. Blood pressure (BP) was measured with a standard digital sphygmomanometer. The homeostasis model assessment of insulin resistance was calculated to determine insulin resistance (IR).


RESULTS
TSH level was significantly higher in obese children with MS than that in the others (p = 0.045). Mean TSH level was not different among the BMI-SDS groups (p = 0.590). TSH levels and the fT3/fT4 ratio were not different in children with dyslipidemia, IR or hypertension (p = 0.515, 0.805, 0.973, 0.750, 0.515, and 0.805, respectively).


CONCLUSIONS
obesity severity does not affect TSH level or the fT3/fT4 ratio in obese children and adolescents. IR is in close relationship with TSH level. Elevated TSH level is a risk factor for MS.
Department of Pediatrics, Gaziosmanpasa University School of Medicine, Tokat.. sozerdr@hotmail.com.
Samet
S
Özer
Department of Biochemistry, Gaziosmanpasa University School of Medicine, Tokat.. sozerdr@hotmail.com.
İlknur
İ
Bütün
Department of Pediatrics, Gaziosmanpasa University School of Medicine, Tokat.. sozerdr@hotmail.com.
Ergün
E
Sönmezgöz
Department of Pediatrics, Gaziosmanpasa University School of Medicine, Tokat.. sozerdr@hotmail.com.
Resul
R
Yılmaz
Department of Bioistatistics, Gaziosmanpasa University School of Medicine, Tokat (Turkey).. sozerdr@hotmail.com.
Osman
O
Demir
D000293:Adolescent; D000886:Anthropometry; D015415:Biomarkers; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D009765:Obesity / Q000097:blood* / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013963:Thyroid Hormones / Q000097:blood*; D014421:Turkey / Q000453:epidemiology
D015415:Biomarkers; D013963:Thyroid Hormones