Life Threatening, Allopurinol-related Dress Syndrome as a Rare Cause of Fever of Unknown Origin.
Drug reaction eosinophilia with systemic symptoms (DRESS) syndrome is a potentially life threatening condition secondary to the usage of a wide type of drugs. A 38-year-old woman under allopurinol therapy for hyperuricemia was admitted in our department with fever and a diffuse cutaneous erythematous eruption. A few days after admission she developed rapidly progressive signs of acute liver and kidney failure. Subsequently, her clinical conditions shortly improved. The histologic findings obtained from skin and liver biopsies were consistent with a toxic drug reaction. The patient completely recovered and has been healthy for five years.
Internal Medicine Unit, Val d'Arda Hospital, Italy.
Giuseppe
G
Civardi
Luca
L
Zanlari
Emanuele
E
Bassi
Adriano
A
Zangrandi
Anna
A
Maria Cesinaro
Sofia
S
Nosseir
Nicola
N
De Maria
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000150:complications* / Q000209:etiology; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology*; D006074:Gout Suppressants / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy*; D012867:Skin / Q000473:pathology*; D016896:Treatment Outcome
D006074:Gout Suppressants; D000493:Allopurinol