Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum.
In an ongoing program to identify new anti-infective leads, an extract derived from whole plant material of Desmodium congestum collected in the Sarawak rainforest was found to have anti-MRSA activity. Bioassay-guided isolation led to the isolation of two new prenylated chalcones, 5'-O-methyl-3-hydroxyflemingin A (1) and 5'-O-methylflemingin C (2), which were closely related to the flemingins previously isolated from various Flemingia species. Chalcones 1 and 2, which were determined to be 4:6 enantiomeric mixtures by chiral HPLC, exhibited moderate activity against a panel of Gram-positive bacteria and were also cytotoxic to the HEK293 human embryonic kidney cell line.
Karlee A
KA
Rees
Cindy
C
Bermudez
David J
DJ
Edwards
Alysha G
AG
Elliott
Sarawak Biodiversity Centre , KM 20 Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, 93990 Kuching, Sarawak, Malaysia.
Jovita E
JE
Ripen
Sarawak Biodiversity Centre , KM 20 Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, 93990 Kuching, Sarawak, Malaysia.
Cynthia
C
Seta
Johnny X
JX
Huang
Matthew A
MA
Cooper
James A
JA
Fraser
Sarawak Biodiversity Centre , KM 20 Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, 93990 Kuching, Sarawak, Malaysia.
Tiong Chia
TC
Yeo
Mark S
MS
Butler
D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry; D006094:Gram-Positive Bacteria / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D008296:Malaysia; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054876:Prenylation; D065947:Rainforest
D047188:Chalcones