[IMMUNOGENETICS AND PROGRESSION OF CHRONIC VIRAL HEPATITES].
OBJECTIVE
To estimate the role of polymorphic variants of genes IL4 (C-590T), IL4RA (I50V), TNF (G-308A) and SLC1IAI (D543N) in chronic viral hepatitis progression.


METHODS
Overall 121 patients with chronic viral hepatitis C and B.


RESULTS
Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (150V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology the <<Val/Val>> IL4RA gene variant (II50Val) is associated with HBV-infection chronization. The allele <<A>> gene TNF-α (G-308A) is protective for chronic viral hepatitis and is associated with a low level of production by mononuclear cells of TNF-α and IL-12, high secretion of IL-4 and low degree of collagenopathy in the liver. Genotype <<CT>> of IL4 (C-590T) gene is an adverse marker for progression of chronic viral hepatitis B. There was significant correlation of polymorphic variants TNF (G-308A) and IL4 (C-590T) genes with production of the key interleukins, that determine type of immune response (Th-1, Th-2) and products of collagen metabolism that testifies genetic determination of system immune response and collagen formation processes in the liver at chronic viral hepatitis.
E V
EV
Beloborodova
I A
IA
Goncharova
E I
EI
Beloborodova
I L
IL
Purlik
T P
TP
Kalacheva
O E
OE
Akbasheva
M I
MI
Rachkovskiy
V A
VA
Burkovskaya
D000293:Adolescent; D000328:Adult; D000368:Aged; D027682:Cation Transport Proteins / Q000235:genetics / Q000276:immunology; D005260:Female; D019694:Hepatitis B, Chronic / Q000235:genetics / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000235:genetics / Q000276:immunology; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics / Q000276:immunology; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D015847:Interleukin-4; D053662:Interleukin-4 Receptor alpha Subunit; D014409:Tumor Necrosis Factor-alpha; D000099173:Natural Resistance-associated Macrophage Protein 1; C508598:IL4 protein, human; C504000:IL4R protein, human