Quantitative assessment of non-motor fluctuations in Parkinson's disease using the Non-Motor Symptoms Scale (NMSS).
Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. ΔNMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 ± 9.7 years) with mean total NMSS score in On state of 41.5 ± 37.6 and in Off state of 75.6 ± 42.3 (P < 0.001). Scores were higher in Off compared to On state for all domains except for domain "perceptual problems/hallucinations" (P = 0.608). Clinimetric properties of the NMSS were similar to those reported previously for NMS assessments independent of motor oscillations. NMSSOn, NMSSOff and ΔNMSSOn/Off showed weak to moderate correlations with demographics, indicators of motor symptom severity as well as with other measures of NMS, depression and quality of life. Correlations of NMSS items/domains with independent measures of related constructs were weak to moderate. In conclusion, when assessed with the NMSS, a broad range of NMS fluctuate with motor oscillations, but these fluctuations do neither correlate with motor function nor with measures of disease progression.
Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. Alexander.Storch@med.uni-rostock.de.|German Center for Neurodegenerative Diseases (DZNE) Dresden, 01307, Dresden, Germany. Alexander.Storch@med.uni-rostock.de.|Department of Neurology, University of Rostock, 18147, Rostock, Germany. Alexander.Storch@med.uni-rostock.de.
Alexander
A
Storch
Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Christine B
CB
Schneider
Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Lisa
L
Klingelhöfer
Department of Neurology, Klinikum Bremerhaven, 27574, Bremerhaven, Germany.|Department of Neurology, Skane University Hospital, 221 85, Lund, Sweden.
Per
P
Odin
Parkinson Clinic Wolfach, 77709, Wolfach, Germany.
Gerd
G
Fuchs
Department of Neurology, Deutsche Klinik für Diagnostik, 65191, Wiesbaden, Germany.
Wolfgang H
WH
Jost
Research Unit, Alzheimer Center Reina Sofia Foundation and CIBERNED, Carlos III Institute of Health, 28031, Madrid, Spain.
Pablo
P
Martinez-Martin
Department of Medical Informatics and Biometry, Technische Universität Dresden, 01307, Dresden, Germany.
Rainer
R
Koch
Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.
Heinz
H
Reichmann
National Parkinson Foundation Centre of Excellence, Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
K Ray
KR
Chaudhuri
Movement Disorders Clinic, 14547, Beelitz-Heilstätten, Germany.
Georg
G
Ebersbach
D000368:Aged; D003430:Cross-Sectional Studies; D066264:Datasets as Topic; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology*; D010507:Periodicity; D012720:Severity of Illness Index
Apathy; Autonomic dysfunction; Depression; Motor complications; Non-motor fluctuations; Non-motor symptoms; Parkinson’s disease; Quality of life (QoL)