Hypertrophic Pulmonary Osteoarthropathy in Anaplastic Lymphoma Kinase (ALK)-positive Lung Cancer.
A 49-year-old man was admitted to a hospital with chest pain and polyarthralgia. Chest radiography showed abnormal findings, and chest computed tomography showed a mass in the right lung. A transbronchial lung biopsy led to a diagnosis of anaplastic lymphoma kinase (ALK)-positive adenocarcinoma. Bone scintigraphy revealed bilateral symmetrical accumulations of (99m)Technetium complexes in the long bones, suggesting co-existing hypertrophic pulmonary osteoarthropathy (HPO). The patient underwent four courses of chemotherapy with cisplatin plus pemetrexed, which led to decreased (99m)Technetium accumulations in the long bones. To the best of our knowledge, this is the first reported case of HPO associated with ALK-positive lung cancer.
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan.
Masamichi
M
Komatsu
Masanori
M
Yasuo
Nobumitsu
N
Kobayashi
Kazunari
K
Tateishi
Atsuhito
A
Ushiki
Kazuhisa
K
Urushihata
Hiroshi
H
Yamamoto
Masayuki
M
Hanaoka
Hisanori
H
Matoba
Takayuki
T
Honda
Kosuke
K
Ichikawa
D000230:Adenocarcinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D000077548:Anaplastic Lymphoma Kinase; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D002637:Chest Pain / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis*; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases; D013669:Technetium Tc 99m Medronate