Fine-needle aspiration cytology in the evaluation of patients with radiographically occult, palpable breast abnormalities.
BACKGROUND
Patients who present with occult, palpable breast abnormalities on radiographs represent a diagnostic challenge. We hypothesized that fine-needle aspiration cytology (FNAC) would be an accurate method for diagnosing and excluding malignancy in these patients.


METHODS
The records of all patients undergoing FNAC at our institution between 2010 and 2012 were queried; 173 patients with 175 palpable breast masses without an imaging correlate were included.


RESULTS
Of 175 FNAC performed, 2 (1%) were malignant, 16 (9%) were suspicious, and 157 (90%) were benign (n = 75) or nondiagnostic (n = 82). All 16 suspicious FNAC underwent an additional biopsy, of which 4 were malignant. FNAC led to the identification of 6 (3.4%) occult malignancies. At a median follow-up of 16.3 months, 1 patient within the benign cohort was found to have an incidental 2.5 mm cancer identified on reduction mammaplasty, which was unrelated to the index mass. The negative predictive value of FNAC in benign patients was 100%.


CONCLUSIONS
FNAC detected malignancy in a small but significant percentage of patients with a palpable mass and negative breast imaging while excluding carcinoma in the remaining patients. FNAC may be included in the evaluation of patients with occult, palpable breast masses demonstrated on radiography.
Department of Surgery, University of Louisville, Louisville, KY.
Nicolas
N
Ajkay
Department of Surgery, The Bryn Mawr Hospital, Bryn Mawr, PA.
Erica V
EV
Bloomquist
Department of Surgery, University of Louisville, Louisville, KY.
Robert C G
RC
Martin
Department of Surgery, The Bryn Mawr Hospital, Bryn Mawr, PA.
Thomas G
TG
Frazier
Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: barrioa@mskcc.org.
Andrea V
AV
Barrio
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D055815:Young Adult