Low-frequency oscillations in cerebrovascular and cardiovascular hemodynamics: Their interrelationships and the effect of age.
The aim of this study was to investigate how the interrelationships between low-frequency oscillations (LFOs) in the cerebral and systemic cardiovascular hemodynamic systems change with aging and systemic hemodynamic perturbation. Seventeen young adult (28.4±3.5years) and seventeen elderly subjects (69.4±8.7years) underwent continuous measurements of arterial blood pressure (ABP), heart rate (HR), and cerebral oxygenation (oxy-hemoglobin, deoxy-hemoglobin, and total hemoglobin) using near-infrared spectroscopy. The LFOs were subdivided into three frequency intervals (FI-1: 0.01-0.02Hz, FI-2: 0.02-0.06Hz, and FI-3: 0.06-0.15Hz) via spectral analysis based on continuous wavelet transform. The amplitudes of the LFOs at these FIs were calculated to examine the effects of aging and head-up tilt (HUT) on cerebral and cardiovascular hemodynamics. Granger causality (GC) was used for analyzing the causal relationships between the LFOs observed in ABP, oxy-hemoglobin, and HR. The amplitudes of the LFOs were generally higher in young adults than in the elderly and increased significantly only in the younger subjects after HUT. GCs in FI-3 oscillations were significantly higher in young subjects compared to older participants in the HUT state. These results indicate that aging dampens systemic and cerebral hemodynamic regulatory mechanisms, and the interrelationships between systemic and cerebral hemodynamics become weaker with age.
Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Soohwa
S
Song
Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Dohyun
D
Kim
Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Dong Pyo
DP
Jang
Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Jongshill
J
Lee
Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
Hyon
H
Lee
Department of Neurology, Seoul National University Hospital, Seoul, South Korea. Electronic address: kminlee@snu.ac.kr.
Kyoung-Min
KM
Lee
Department of Biomedical Engineering, Hanyang University, Seoul, South Korea. Electronic address: iykim@hanyang.ac.kr.
In Young
IY
Kim
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000502:physiology*; D062186:Arterial Pressure; D002320:Cardiovascular Physiological Phenomena; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared; D058067:Wavelet Analysis
D006454:Hemoglobins; D010108:Oxyhemoglobins; D010100:Oxygen
Age; Granger causality; Head-up tilt; Low-frequency oscillation; Wavelet transform