Serologic testing for celiac disease in young people with elevated transaminases.
OBJECTIVE
A cryptogenic elevation of transaminases is the most common hepatic manifestation in celiac disease (CD). In adult patients and pediatric patients with cryptogenic hypertransaminasemia, the prevalence of CD was 4% and 12%, respectively. However, there are no related data from China in this regard. We aimed to investigate the status of CD in young Chinese patients with elevated transaminases.


METHODS
A total of 125 patients with elevated transaminases and 125 healthy individuals as controls with matched age and sex were involved in the study. Serum markers of hepatitis B were determined in patients with elevated transaminases. All subjects were screened for CD by testing serum IgA antitissue transglutaminase antibodies (anti-tTG IgA), and total serum IgA was determined in order to rule out IgA deficiency.


RESULTS
None of the subjects were seropositive to IgA anti-tTG antibodies. No association between CD and elevated transaminases was found. Hepatitis B viral infections were one of the main causes of raised transaminases.


CONCLUSIONS
Before the exclusion of every known cause of raised transaminase levels, routine serological screening for CD should not be recommended for patients who only present elevated transaminases.
Juanli
J
Yuan
Jinyan
J
Gao
Yonghong
Y
Yao
Hongbing
H
Chen
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood*; D002681:China; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D012698:Serologic Tests; D000637:Transaminases / Q000097:blood*; D011503:Transglutaminases / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D007070:Immunoglobulin A; D011503:Transglutaminases; D000637:Transaminases