Staphylococcal manipulation of host immune responses.
Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is their frequent recurrence, even when treated with antibiotics and surgical intervention, which demonstrates the bacterium's ability to manipulate innate and adaptive immune responses. In this Review, we highlight how S. aureus virulence factors inhibit complement activation, block and destroy phagocytic cells and modify host B cell and T cell responses, and we discuss how these insights might be useful for the development of novel therapies against infections with antibiotic resistant strains such as methicillin-resistant S. aureus.
1] Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA. [2] Regeneron Pharmaceuticals, 755 Old Saw Mill River Road, Tarrytown, New York 10591, USA.
Vilasack
V
Thammavongsa
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.
Hwan Keun
HK
Kim
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.
Dominique
D
Missiakas
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.
Olaf
O
Schneewind
D000371:Agglutination / Q000276:immunology; D003167:Complement Activation; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D006801:Humans; D057131:Immune Evasion; D008213:Lymphocyte Activation; D010587:Phagocytosis; D013203:Staphylococcal Infections / Q000276:immunology* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000502:physiology*; D037521:Virulence Factors / Q000378:metabolism
D037521:Virulence Factors