A small-scale open-label study of the treatment of canine flea allergy dermatitis with fluralaner.
BACKGROUND
Fluralaner is an isoxazoline systemic insecticide and acaricide that provides persistent flea-killing activity on dogs for 12 weeks. European and US field studies have shown that fluralaner treatment alleviates the signs of flea allergy dermatitis (FAD) in client-owned dogs.


OBJECTIVE
To assess the clinical response in FAD affected dogs over the 12-week period following a single oral fluralaner treatment.


METHODS
Twenty client-owned dogs were diagnosed with FAD on the basis of compatible clinical signs and a positive response in flea antigen tests, using intradermal and or serological methods.


METHODS
An open-label small-scale study with all dogs receiving a single oral fluralaner treatment. All enrolled dogs were diagnosed with FAD and then clinically monitored at 4-week intervals for 12 weeks. Twenty dogs completed the study.


RESULTS
All dogs were flea-free at all post-treatment assessments except for one dog that had a single flea at the first post-enrollment assessment at 4 weeks. At the 4-week post-treatment assessment active FAD signs had resolved in all dogs; at 8 weeks post-treatment, two dogs showed mild signs. All clinical signs of FAD had resolved at the final assessment of 12 weeks after treatment.


CONCLUSIONS
A single administration of fluralaner alleviated or resolved signs associated with FAD in all treated dogs over the recommended 12-week treatment period.
MSD Animal Health, 26 Artisan Road, Seven Hills, 2147, NSW, Australia.
Petr
P
Fisara
Dermatology for Animals, 263 Appleby Road, Stafford Heights, 4053, NSW, Australia.
Michael
M
Shipstone
von Berky Veterinary Services, 3 Hawthorne street, Woody Point, QLD, 4019, Australia.
Andrew
A
von Berky
von Berky Veterinary Services, 3 Hawthorne street, Woody Point, QLD, 4019, Australia.
Janet
J
von Berky
D000284:Administration, Oral; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology*; D004285:Dogs; D005260:Female; D058267:Flea Infestations / Q000276:immunology / Q000662:veterinary*; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male
C000591860:A1443 compound; D007306:Insecticides; D007555:Isoxazoles