Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes.
Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm(2) power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity.
Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. khachatur.julfakyan@kaust.edu.sa.
Khachatur
K
Julfakyan
Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. yevhen.fatieiev@kaust.edu.sa.
Yevhen
Y
Fatieiev
Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. shahad.alsaiari@kaust.edu.sa.
Shahad
S
Alsaiari
Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. lin.deng@kaust.edu.sa.
Lin
L
Deng
Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. alaa.ezzeddine@kaust.edu.sa.
Alaa
A
Ezzeddine
Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. zhang-chem@hotmail.com.|Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. zhang-chem@hotmail.com.
Dingyuan
D
Zhang
Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Vincent M
VM
Rotello
Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. niveen.khashab@kaust.edu.sa.
Niveen M
NM
Khashab
D001672:Biocompatible Materials; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008422:Materials Testing; D008872:Microwaves / Q000009:adverse effects*; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*
D001672:Biocompatible Materials; D007211:Indoles; D058185:Magnetite Nanoparticles; D011108:Polymers; C568283:polydopamine
FeCo nanocubes; microwave radiation; nanomedicine; polydopamine