Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson's disease symptoms without side effects.
A 65-year-old male, Parkinson's disease patient, was evaluated for GPR109A expression, niacin index, UPDRS scale, handwriting test, and quality of sleep with and without niacin treatment. The evaluation was repeated 3 months after niacin was stopped. Niacin modulated the abovementioned parameters and showed the overall improvement without side effects.
Department of Physical Therapy, Georgia Regents University 1120, 15th Street, Augusta, Georgia, 30912, USA.
Chandramohan
C
Wakade
Department of Physical Therapy, Georgia Regents University 1120, 15th Street, Augusta, Georgia, 30912, USA.
Raymond
R
Chong
Department of Physical Therapy, Georgia Regents University 1120, 15th Street, Augusta, Georgia, 30912, USA.
Eric
E
Bradley
Department of Neurology, Georgia Regents University 1120, 15th Street, Augusta, Georgia, 30912, USA.
John C
JC
Morgan
GPR109A; Parkinson’s disease; inflammation; niacin