Mechanisms of Beta Cell Dysfunction Associated With Viral Infection.
Type 1 diabetes (T1D) results from genetic predisposition and environmental factors leading to the autoimmune destruction of pancreatic beta cells. Recently, a rapid increase in the incidence of childhood T1D has been observed worldwide; this is too fast to be explained by genetic factors alone, pointing to the spreading of environmental factors linked to the disease. Enteroviruses (EVs) are perhaps the most investigated environmental agents in relationship to the pathogenesis of T1D. While several studies point to the likelihood of such correlation, epidemiological evidence in its support is inconclusive or in some instances even against it. Hence, it is still unknown if and how EVs are involved in the development of T1D. Here we review recent findings concerning the biology of EV in beta cells and the potential implications of this knowledge for the understanding of beta cell dysfunction and autoimmune destruction in T1D.
Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, Technische Universität Dresden, Fetscherstr.74, 01307, Dresden, Germany, antje.petzold@mailbox.tu-dresden.de.
Antje
A
Petzold
Michele
M
Solimena
Klaus-Peter
KP
Knoch
D000818:Animals; D003384:Coxsackievirus Infections / Q000150:complications*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000235:genetics; D004769:Enterovirus Infections / Q000150:complications*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000473:pathology
D007328:Insulin