A peptide-based pH-sensitive drug delivery system for targeted ablation of cancer cells.
A peptide-guided prodrug incorporating a tumor-specific peptide, doxorubicin, and a pH-sensitive hydrazone bridge was developed for targeted ablation of cancer cells with minimal side cytotoxicity.
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. yyhuang@iccas.ac.cn zhaorui@iccas.ac.cn.
Yulong
Y
Jin
Yanyan
Y
Huang
Hua
H
Yang
Guoquan
G
Liu
Rui
R
Zhao
D000970:Antineoplastic Agents / Q000008:administration & dosage; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010455:Peptides / Q000737:chemistry*
D000970:Antineoplastic Agents; D010455:Peptides