Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats.
Swertianlarin is an herbal agent abundantly distributed in Swertia mussotii Franch, a Chinese traditional herb used for treatment of jaundice. To study the therapeutic effect of swertianlarin on cholestasis, liver injury, serum proinflammatory cytokines, and bile salt concentrations were measured by comparing rats treated with swertianlarin 100 mg/kg/d or saline for 3, 7, or 14 days after bile duct ligation (BDL). Serum alanine aminotransferase (ATL) and aspartate aminotransferase (AST) levels were significantly decreased in BDL rats treated with swertianlarin for 14 days (P < 0.05). The reduced liver injury in BDL rats by swertianlarin treatment for 14 days was further confirmed by liver histopathology. Levels of serum tumor necrosis factor alpha (TNFα) were decreased by swertianlarin in BDL rats for 3 and 7 days (P < 0.05). Moreover, reductions in serum interleukins IL-1β and IL-6 levels were also observed in BDL rats treated with swertianlarin (P < 0.05). In addition, most of serum toxic bile salt concentrations (e.g., chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA)) in cholestatic rats were decreased by swertianlarin (P < 0.05). In conclusion, the data suggest that swertianlarin derived from Swertia mussotii Franch attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats.
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Liangjun
L
Zhang
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Ying
Y
Cheng
Department of Traditional Chinese Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Xiaohuang
X
Du
Department of Pediatrics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Sheng
S
Chen
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Xinchan
X
Feng
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Yu
Y
Gao
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Shaoxue
S
Li
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Li
L
Liu
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Mei
M
Yang
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Lei
L
Chen
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Zhihong
Z
Peng
Chongqing Academy of Chinese Material Medicine, Chongqing 400065, China.
Yong
Y
Yang
Chongqing Academy of Chinese Material Medicine, Chongqing 400065, China.
Weizao
W
Luo
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Rongquan
R
Wang
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Wensheng
W
Chen
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Jin
J
Chai