Pitfalls and Limitations of Radionuclide Planar and Hybrid Bone Imaging.
The radionuclide (99m)Tc-MDP bone scan is one of the most commonly performed nuclear medicine studies and helps in the diagnosis of different pathologies relating to the musculoskeletal system. With its increasing utility in clinical practice, it becomes more important to be aware of various limitations of this imaging modality to avoid false interpretation. It is necessary to be able to recognize various technical, radiopharmaceutical, and patient-related artifacts that can occur while carrying out a bone scan. Furthermore, several normal variations of tracer uptake may mimic pathology and should be interpreted cautiously. There is an important limitation of a bone scan in metastatic disease evaluation as the inherent mechanism of tracer uptake is not specific for tumor but primarily relies on an osteoblastic response. Thus, it is crucial to keep in mind uptake in benign lesions, which can resemble malignant pathologies. The utility of a planar bone scan in benign orthopedic diseases, especially at sites with complex anatomy, is limited owing to lack of precise anatomical information. SPECT/CT has been significantly helpful in these cases. With wider use of PET/CT and reintroduction of the (18)F-fluoride bone scan, increasing knowledge of potential pitfalls on an (18)F-fluoride bone scan and (18)F-FDG-PET/CT will help in improving the accuracy of clinical reports.
Department of Nuclear Medicine, Guy׳s & St Thomas׳ NHS Foundation Trust, London, UK. Electronic address: drkanis@gmail.com.
Kanhaiyalal
K
Agrawal
Department of Nuclear Medicine, Kuwait Cancer Control Center (KCCC), King's College, London.
Fahad
F
Marafi
Department of Nuclear Medicine, Guy׳s & St Thomas׳ NHS Foundation Trust, London, UK.
Gopinath
G
Gnanasegaran
Department of Nuclear Medicine, Concord Nuclear Imaging, Concord West, New South Wales, Australia.
Hans
H
Van der Wall
Department of Nuclear Medicine, Kuwait Cancer Control Center (KCCC), King's College, London.
Ignac
I
Fogelman
D000818:Animals; D016477:Artifacts; D001859:Bone Neoplasms / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods*; D011877:Radionuclide Imaging / Q000379:methods*