C3dg-CR3 interaction in erythrophagocytosis.
In this issue of Blood, Lin et al elegantly demonstrate that the erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) undergoing eculizumab treatment, which are opsonized with the complement C3dg, can interact with complement receptor 3 (CR3) on activated monocytes, thus leading to erythrophagocytosis.
CENTRE DE RECHERCHE DES CORDELIERS.
Lubka T
http://orcid.org/0000-0002-9940-0324
LT
Roumenina
D006457:Hemoglobinuria, Paroxysmal / Q000097:blood* / Q000276:immunology*; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*
D010446:Peptide Fragments