Applications of bacillus Calmette-Guerin and recombinant bacillus Calmette-Guerin in vaccine development and tumor immunotherapy.
Bacillus Calmette-Guerin (BCG) vaccines are attenuated live strains of Mycobacterium bovis and are among the most widely used vaccines in the world. BCG is proven to be effective in preventing severe infant meningitis and miliary tuberculosis. Intravesical instillation of BCG is also a standard treatment for non-muscle invasive bladder cancer. In the past few decades, recombinant BCG (rBCG) technology had been extensively applied to develop vaccine candidates for a variety of infectious diseases, including bacterial, viral, and parasite infections, and to improve the efficacy of BCG in bladder cancer therapy. This review is intended to show the vast applications of BCG and recombinant BCG (rBCG) in the prevention of infectious diseases and cancer immunotherapy, with a special emphasis on recent approaches and trends on both pre-clinical and clinical levels.
Inner Mongolia Key Laboratory of Molecular Biology, Inner Mongolia Medical University, Hohhot 010059, China.
Yuan-qiang
YQ
Zheng
Youssef W
YW
Naguib
Yixuan
Y
Dong
Yan-chun
YC
Shi
Shorgan
S
Bou
Zhengrong
Z
Cui
D001424:Bacterial Infections / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology*; D019496:Cancer Vaccines / Q000235:genetics / Q000276:immunology*; D004337:Drug Carriers; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D006801:Humans; D009163:Mycobacterium bovis / Q000235:genetics*; D009369:Neoplasms / Q000628:therapy; D010272:Parasitic Diseases / Q000517:prevention & control; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology*; D014777:Virus Diseases / Q000517:prevention & control
D001428:Bacterial Vaccines; D019496:Cancer Vaccines; D004337:Drug Carriers; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
Bacillus Calmette-Guerin; bacterial vector; bladder cancer; clinical applications; infectious disease; recombinant BCG; tumor; vaccine development