Vaccination in patients with primary immune deficiency, secondary immune deficiency and autoimmunity with immune regulatory abnormalities.
Vaccination has been an important healthcare measure in preventing infectious diseases. The response to vaccination is reduced in immunocompromised patients, primary immune deficiency (PID) and secondary immune deficiency (SID), but vaccination studies still demonstrated a protective effect resulting in reducing complications, hospitalization, treatment costs and even mortality. The primary physician and the specialist directing patient care are responsible for vaccination. Live vaccines are contraindicated in patients with severe immune impairment, killed vaccines are highly recommended in PID and SID. Criteria have been defined to distinguish high- or low-level immune impairment in the different disease entities among PID and SID patients. For patients who do not respond to diagnostic vaccination as characterized by antibody failure immunoglobulin replacement is the mainstay of therapy.
Immunology Outpatient Clinic, Schwarzspanierstrasse 15,1090 Vienna, Austria.
Martha M
MM
Eibl
Immunology Outpatient Clinic, Schwarzspanierstrasse 15,1090 Vienna, Austria.
Hermann M
HM
Wolf
D001327:Autoimmune Diseases / Q000276:immunology; D003140:Communicable Disease Control / Q000592:standards*; D000075202:Contraindications; D006282:Health Personnel; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D016377:Organ Transplantation / Q000009:adverse effects; D017410:Practice Guidelines as Topic; D014611:Vaccination / Q000592:standards*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D062690:Vaccines, Live, Unattenuated / Q000008:administration & dosage / Q000276:immunology
D015164:Vaccines, Inactivated; D062690:Vaccines, Live, Unattenuated
immunization; immunodeficiency; primary; secondary; timing; vaccination