Effects of dexmedetomidine on the protection of hyperoxia-induced lung injury in newborn rats.
Dexmedetomidine (Dex) is a specific agonist of α2-adrenoceptor and was reported to have protective effect on a variety of organs, however the effect of Dex on hyperoxia-induced lung injury remains unknown. In the present study, Dex was administrated to newborn rats and its effect against hyperoxia-induced lung injury was examined. The results showed that, Dex significantly attenuated the aberration, macrophage infiltration, inflammatory responses and pulmonary edema induced by hyperoxia. In addition, the down-regulation of AQP1 was also reversed by Dex. These data indicate that Dex may be a potential therapy in the prevention of hyperoxia-induced lung injury in infants.
Department of Paediatrics, The First Affiliated Hospital of Harbin Medical University Harbin 150001, People's Republic of China.
Qiuyue
Q
Zhang
Department of Paediatrics, The First Affiliated Hospital of Harbin Medical University Harbin 150001, People's Republic of China.
Di
D
Wu
Department of Paediatrics, The First Affiliated Hospital of Harbin Medical University Harbin 150001, People's Republic of China.
Yang
Y
Yang
Department of Paediatrics, The First Affiliated Hospital of Harbin Medical University Harbin 150001, People's Republic of China.
Tingting
T
Liu
Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University Harbin 150001, People's Republic of China.
Hongyu
H
Liu
D058647:Adrenergic alpha-2 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D051398:Aquaporin 1 / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D019610:Cytoprotection; D020927:Dexmedetomidine / Q000494:pharmacology*; D004195:Disease Models, Animal; D018496:Hyperoxia / Q000150:complications / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D011014:Pneumonia / Q000209:etiology / Q000517:prevention & control; D011654:Pulmonary Edema / Q000209:etiology / Q000517:prevention & control; D017207:Rats, Sprague-Dawley
D058647:Adrenergic alpha-2 Receptor Agonists; C496022:Aqp1 protein, rat; D016207:Cytokines; D018836:Inflammation Mediators; D051398:Aquaporin 1; D020927:Dexmedetomidine
AQP1; Dexmedetomidine; hyperoxia-induced lung injury; inflammatory responses; pulmonary edema