Lighting Up Genes in Single Cells at Scale.
In this issue, Shachar et al. report a high-throughput imaging position mapping platform (HIPmap) enabling large-scale, high-resolution localization of 3D gene positions in single cells. Coupling loss-of-function screens with HIPmap, the authors identify DNA replication rather than mitosis as a major determinant of genome positioning.
Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA. Electronic address: liuz11@janelia.hhmi.org.
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D002467:Cell Nucleus / Q000235:genetics*; D005796:Genes; D005821:Genetic Techniques; D006801:Humans