Identifying patients infected with hepatitis B virus in sub-Saharan Africa: potential for misclassification.
Most research in sub-Saharan Africa establishes hepatitis B infection via one-time hepatitis B surface antigen (HBsAg) testing. Of 237 HIV-infected patients from two clinical trials testing HBsAg positive (MiniVidas®), 206 (86.9%) had validated serological tests using another assay (Architect). Discrepancies could be due to inactive infection, highlighting the importance of assessing hepatitis B virus infection phase.
INSERM, UMR_S1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France. Electronic address: anders.boyd@upmc.fr.
Anders
A
Boyd
Laboratoire de Virologie, Hôpital Saint-Louis, AP-HP, Paris, France; Université Paris-Diderot, Paris, France.
Sarah
S
Maylin
Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire.
Raoul
R
Moh
INSERM, U897, Epidémiologie-Biostatistique, Bordeaux, France; University of Bordeaux, ISPED, Bordeaux, France.
Delphine
D
Gabillard
Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire; Centre de Diagnostic et de Recherche sur le SIDA et les Maladies Opportunistes (CeDReS), Centre Hospitalier Universitaires (CHU) de Treichville, Abidjan, Côte d'Ivoire.
Hervé
H
Menan
Laboratoire de Virologie, Hôpital Saint-Louis, AP-HP, Paris, France; Université Paris-Diderot, Paris, France.
Nadia
N
Mahjoub
Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire; INSERM, U897, Epidémiologie-Biostatistique, Bordeaux, France; University of Bordeaux, ISPED, Bordeaux, France.
Christine
C
Danel
Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire; INSERM, U897, Epidémiologie-Biostatistique, Bordeaux, France; University of Bordeaux, ISPED, Bordeaux, France.
Xavier
X
Anglaret
Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire; Department of Infectious and Tropical Diseases, Treichville University Teaching Hospital, Abidjan, Côte d'Ivoire; Medical School, University Felix Houphouet Boigny, Abidjan, Côte d'Ivoire.
Serge Paul
SP
Eholié
Department of Infectious and Tropical Diseases, Saint-Antoine Hospital, AP-HP, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
Pierre-Marie
PM
Girard
Centre de Recherche sur le Cancer de Lyon, Equipes 15 et 16, INSERM, Unité 1052, CNRS, UMR 5286, Lyon, France.
Fabien
F
Zoulim
Laboratoire de Virologie, Hôpital Saint-Louis, AP-HP, Paris, France; INSERM U941, Paris, France; Université Paris-Diderot, Paris, France.
Constance
C
Delaugerre
Department of Infectious and Tropical Diseases, Saint-Antoine Hospital, AP-HP, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
Karine
K
Lacombe
D000328:Adult; D017954:Africa South of the Sahara; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications; D006509:Hepatitis B / Q000175:diagnosis*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
Bias; Hepatitis B virus; Hepatitis surface antigen; Inactive hepatitis B infection; Isolated hepatitis B core antigen