Early De Novo Donor Specific Antibody Involvement in Delayed Graft Function After Kidney Transplantation: A Report of 2 Cases.
Kidney tubular damage caused by ischemia-reperfusion injury is considered the major cause of delayed graft function (DGF) after renal transplantation. It is not clear whether early generated de novo donor specific antibodies (DSA) play a role in DGF. Here, we report 2 cases of renal transplant with DGF, which seems to be associated with de novo DSA. When the early produced de novo DSA are not potent enough to mediate acute rejection, they may cause mild intra-graft injury, which has a significant impact on the degree of DGF and its recovery. Antibody-targeted therapy seems to be beneficial to the recovery of patients with DGF.
Lan
L
Zhu
Gang
G
Chen
Weijie
W
Zhang
Hui
H
Guo
Zhengbin
Z
Lin
Dunfeng
D
Du
Song
S
Chen
Huibo
H
Shi
Shenwei
S
Liu
Zhishui
Z
Chen
D000328:Adult; D015415:Biomarkers / Q000097:blood; D051799:Delayed Graft Function / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D003888:Desensitization, Immunologic / Q000379:methods; D004359:Drug Therapy, Combination; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006648:Histocompatibility; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007518:Isoantibodies / Q000097:blood*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D019520:Living Donors; D008875:Middle Aged; D020127:Recovery of Function; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D007518:Isoantibodies