Complete Genome Sequences of Low-Passage Virulent and High-Passage Avirulent Variants of Pathogenic Leptospira interrogans Serovar Manilae Strain UP-MMC-NIID, Originally Isolated from a Patient with Severe Leptospirosis, Determined Using PacBio Single-Molecule Real-Time Technology.
Here, we report the complete genome sequences of low-passage virulent and high-passage avirulent variants of pathogenic Leptospira interrogans serovar Manilae strain UP-MMC-NIID, a major causative agent of leptospirosis. While there were no major differences between the genome sequences, the levels of base modifications were higher in the avirulent variant.
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan kazuhito.satou@oias.or.jp.
Kazuhito
http://orcid.org/0000-0003-4230-7644
K
Satou
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Makiko
M
Shimoji
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Hinako
H
Tamotsu
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Ayaka
A
Juan
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Noriko
N
Ashimine
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Misuzu
M
Shinzato
Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
Claudia
C
Toma
Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
Toshitsugu
T
Nohara
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Akino
http://orcid.org/0000-0003-2109-239X
A
Shiroma
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Kazuma
K
Nakano
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Kuniko
K
Teruya
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Yasunobu
Y
Terabayashi
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Shun
S
Ohki
Department of Bacteriology I, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Nobuo
N
Koizumi
Department of Biological Sciences, Okinawa Prefectural Institute of Health and Environment, Nanjo, Okinawa, Japan.
Shou
S
Okano
Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
Toshihiko
T
Suzuki
Okinawa Institute of Advanced Sciences, Uruma, Okinawa, Japan.
Takashi
T
Hirano