Docosahexaenoic Acid-Phosphatidylcholine Improves Cognitive Deficits in an Aβ23-35-Induced Alzheimer's Disease Rat Model.
Both Docosahexaenoic acid (DHA) and Phosphatidylcholine (PC) have been shown to halt the pathogenesis of Alzheimer disease (AD) and vascular dementia. This study aimed to investigate the role of DHA-containing PC (DHA-PC) in the improvement of Aβ25-35-induced cognitive deficits in rats. Aβ25-35-induced AD rats were treated for 30 days with DHA-PC, which was extracted from Sthenoteuthis oualaniensis spawns. Cognitive improvement of the AD rats was detected using the Morris water maze (MWM). The results demonstrated that DHA-PC could improve the learning and memory abilities of AD rats in a dose-dependent pattern. Further analyses showed that expression of phosphorylated tau decreased, and the neuronal morphology recovered in brains of DHA-PC-treated AD rats, as compared with mock-treated AD rats. In addition, DHAPC treatment increased the activity of GSH-Px and SOD in the cortex and hippocampus of AD rats. Taken together, these data suggest that DHA-PC is able to improve the cognitive deficits in AD rats, probably through decreasing the phosphorylation of tau in the cortex and hippocampus CA1 area, and increasing the GSH-Px and SOD activities in the brain of AD rats.
7166 Baotong West Street, Key Lab of Applied Pharmacology in Universities of Shandong, Department of Pharmacology, Weifang Medical University, Weifang 261053, China. qumeihua@hotmail.com.
Mei-Hua
MH
Qu
Xiaoyun
X
Yang
Yuming
Y
Wang
Qingjuan
Q
Tang
Hailin
H
Han
Jia
J
Wang
Guo-Du
GD
Wang
Changhu
C
Xue
Zhiqin
Z
Gao
D000544:Alzheimer Disease / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D003072:Cognition Disorders / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D049832:Decapodiformes; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism* / Q000633:toxicity; D010713:Phosphatidylcholines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D010713:Phosphatidylcholines; C074636:amyloid beta-protein (25-35); D004281:Docosahexaenoic Acids