Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer.
This review compares the safety and efficacy of boron neutron capture therapy (BNCT) in the treatment of previously irradiated, inoperable locoregional recurrent HNC patients and compares BNCT against the standard treatment of platinum-based chemotherapy. Our analysis of published clinical trials highlights efficacy of BNCT associated with mild side effects. However, the use of BNCT should be explored in stratified randomised trials.
Applied Radiation Therapy Trinity, Discipline of Radiation Therapy, School of Medicine, Trinity Centre for Health sciences, Trinity College Dublin, Ireland.
Diana
D
Lim
Department of Radiation Oncology, National Cancer Centre, Singapore.
Daniel S C
DS
Quah
Applied Radiation Therapy Trinity, Discipline of Radiation Therapy, School of Medicine, Trinity Centre for Health sciences, Trinity College Dublin, Ireland.
Michelle
M
Leech
Applied Radiation Therapy Trinity, Discipline of Radiation Therapy, School of Medicine, Trinity Centre for Health sciences, Trinity College Dublin, Ireland. Electronic address: marignol@tcd.ie.
Laure
L
Marignol
D000328:Adult; D000368:Aged; D016754:Boron Neutron Capture Therapy; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local