[Detection of cytochrome P450 3A4 gene polymorphism guides for labor analgesia with sufentanil medication].
OBJECTIVE
To investigate the relationship between single nucleotide polymorphisms (SNPs) of cytochrome P450 (CYP450) 3A4 rs2242480 and inter-individual differences of sufentanil consumption in accouchement sans douleur.


METHODS
A total of 131 parturient women were collected. According to the distribution of genotypes and allele frequencies of rs2242480, the doses of sufentanil were individually designed. CC homozygotes were given the standard analgesia dose, CT heterozygotes and TT homozygotes were given 87.6% of standard sufentanil dose.


RESULTS
Visual analogue score (VAS) between CC group and CT/TT group were 3.67±1.2 and 3.44±1.5, consistent with the expected analgesic standards. The difference was not statistically significant.


CONCLUSIONS
The parturient women carrying CT heterozygotes and TT homozygotes of CYP3A4 rs2242480 required less sufentanil in accouchement sans douleur.
Department of Pharmacy, Haidian Maternal & Health Hospital, Beijing 100080, China.
Li-qun
LQ
Chi
Department of Pharmacy, Haidian Maternal & Health Hospital, Beijing 100080, China.
Xin
X
Lu
Department of Pharmacy, Haidian Maternal & Health Hospital, Beijing 100080, China.
Lei
L
Wang
Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
Shu-ping
SP
Liu
Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
Nan
N
Ding
Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
Hong-ying
HY
Zhang
Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
Wen
W
E
D000698:Analgesia; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D051544:Cytochrome P-450 CYP3A / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D017409:Sufentanil / Q000627:therapeutic use*
D000701:Analgesics, Opioid; D017409:Sufentanil; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human