Decreased expression of miR-378 correlates with tumor invasiveness and poor prognosis of patients with glioma.
microRNAs (miRNAs) are a class of small non-coding RNAs that play important roles in a variety of biological process. It has been reported that dysregulation of miRNA is always associated with cancer progression and development, and miR-378 aberrant expression has been found in some types of cancers. However, the association of miR-378 and glioma has not been evaluated. In this work, we measured the expression of miR-378 in glioma tissues and non-neoplastic brain tissues was measured using real-time PCR, and found that miRNA-378 expression level was significantly lower in glioma tissues compared with non-neoplastic brain tissues. Patients with lower miR-378 expression level had significantly poorer overall survival. Multivariate Cox regression analysis showed that miR-378 expression was an independent prognostic factor for 5-year overall survival. Over-expression of miR-378 inhibits glioma cell migration and invasion. In conclusion, our results indicated that miR-378 may serve as a tumor suppressor and play an important role in inhibiting tumor migration and invasion. Our work implicates the potential effect of miR-378 on the prognosis of glioma.
Department of Neurosurgery, Wuxi Second People's Hospital 68 Zhong Shan Road, Wuxi 214002, Jiangsu, China.
Bing
B
Li
Department of Hepatic Surgery, Fudan University Shanghai Cancer Center Shanghai 200032, China.
Yilin
Y
Wang
Department of Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University 1665 Kongjiang Road, Shanghai 200092, China.
Shiting
S
Li
Department of Neurosurgery, Changzheng Hospital, Second Military Medical University 415 Feng Yang Road, Shanghai 200003, China.
Hua
H
He
Department of Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University 1665 Kongjiang Road, Shanghai 200092, China.
Fengbin
F
Sun
Department of Neurosurgery, 105 Hospital of PLA 424 West Changjiang Road, Hefei 230000, Anhui, China.
Chunlin
C
Wang
Department of Neurosurgery, Changzheng Hospital, Second Military Medical University 415 Feng Yang Road, Shanghai 200003, China.
Yicheng
Y
Lu
Department of Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University 1665 Kongjiang Road, Shanghai 200092, China.
Xiaoqiang
X
Wang
Department of Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University 1665 Kongjiang Road, Shanghai 200092, China.
Bangbao
B
Tao
D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000628:therapy; D045744:Cell Line, Tumor; D002465:Cell Movement; D016009:Chi-Square Distribution; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D013997:Time Factors; D014162:Transfection; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; C526012:MIRN378 microRNA, human; D035683:MicroRNAs
cell migration and invasion; glioma; miR-378; prognosis