Reduced sweet and fatty fluid intake after Roux-en-Y gastric bypass in rats is dependent on experience without change in stimulus motivational potency.
Here we assessed how intake reductions induced by Roux-en-Y gastric bypass surgery (RYGB) occur within and across access periods by examining drinking microstructure. After training, RYGB (n = 8-10) or sham-operated (SHAM, n = 12) rats were given 60-min access first to 0.3 M sucrose, then to 5% Intralipid, and finally to milk-chocolate Ensure Plus across 5 days each. Initially, total licks taken during the first meal of sucrose and Intralipid by RYGB and SHAM rats did not differ, but, across subsequent test periods, RYGB rats licked less than SHAM rats. First Ensure meal size also did not differ between RYGB and SHAM rats, but SHAM rats increased licking across test periods while the behavior of RYGB rats remained stable. The intake differences between the surgical groups, when they occurred, were most often due to smaller burst sizes in RYGB rats. Importantly, the surgical-group difference in sucrose and Intralipid intakes could not be explained by altered palatability of these solutions because, throughout testing, both groups had similar early meal licking behavior thought to represent the motivational potency of stimulus orosensory features. Although, overall, RYGB rats displayed lower early meal licking of Ensure relative to the SHAM rats, this appeared to be driven primarily by increases in the latter group across test periods; the RYGB group stayed relatively stable. Collectively, these results suggest that some level of postoral experience with these stimuli and/or their components is necessary before intake differences emerge between surgical groups, and, even when differences occur, often immediate taste-motivated ingestive behavior remains unaltered.
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida;
Clare M
CM
Mathes
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida;
Ryan A
RA
Bohnenkamp
Diabetes Complications Research Centre, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland; Investigative Medicine, Imperial College London, London, United Kingdom; and Gastrosurgical Laboratory, University of Gothenburg, Gothenburg, Sweden.
Carel W
CW
le Roux
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida; spector@psy.fsu.edu.
Alan C
AC
Spector
D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage*; D004655:Emulsions; D005247:Feeding Behavior / Q000502:physiology*; D015390:Gastric Bypass; D008297:Male; D010743:Phospholipids; D051381:Rats; D017207:Rats, Sprague-Dawley; D013024:Soybean Oil; D013395:Sucrose; D013549:Sweetening Agents; D014812:Vitamin K
D004041:Dietary Fats; D004655:Emulsions; C029401:Ensure Plus; D010743:Phospholipids; D013549:Sweetening Agents; C545823:soybean oil, phospholipid emulsion; D014812:Vitamin K; D013395:Sucrose; D013024:Soybean Oil
bariatric surgery; conditioned avoidance; fat; licking patterns; sugar