Adsorption removal of antiviral drug oseltamivir and its metabolite oseltamivir carboxylate by carbon nanotubes: Effects of carbon nanotube properties and media.
This investigation evaluated the adsorption behavior of the antiviral drugs of oseltamivir (OE) and its metabolites (i.e., oseltamivir carboxylate (OC)) on three types of carbon nanotubes (CNTs) including single-walled CNT (SWCNT), multi-walled CNT (MWCNT), and carboxylated SWCNT (SWCNT-COOH). CNTs can efficiently remove more than 90% of the OE and OC from aqueous solution when the initial concentration was lower than 10(-4) mmol/L. The Polanyi-Manes model depicted the adsorption isotherms of OE and OC on CNTs better than the Langmuir and Freundlich models. The properties of OE/OC and the characteristics of CNTs, particularly the oxygen functional groups (e.g., SWCNT-COOH) played important roles during the adsorption processes. OE showed a higher adsorption affinity than OC. By comparing the different adsorbates adsorption on each CNT and each adsorbate adsorption on different CNTs, the adsorption mechanisms of hydrophobic interaction, electrostatic interaction, van der Waals force, and H-bonding were proposed as the contributing factors for OE and OC adsorption on CNTs. Particularly, for verifying the contribution of electrostatic interaction, the changes of adsorption partition efficiency (Kd) of OE and OC on CNTs were evaluated by varying pH from 2 to 11 and the importance of isoelectric point (pHIEP) of CNTs on OE and OC adsorption was addressed.
Environmental Simulation and Pollution Control State Key Joint Laboratory, State Environmental Protection Key Laboratory of Microorganism Application and Risk Control (SMARC), School of Environment, Tsinghua University, Beijing 100084, PR China; Shenzhen Laboratory of Microorganism Application and Risk Control, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, PR China.
Wen-Long
WL
Wang
Shenzhen Laboratory of Microorganism Application and Risk Control, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, PR China. Electronic address: wuqianyuan@tsinghua.edu.cn.
Qian-Yuan
QY
Wu
Environmental Management Technology Research Institute, National Institute of Advanced Industrial Science and Technology, Onogawa 16-1, Tsukuba 305-8569, Japan. Electronic address: zm-wang@aist.go.jp.
Zheng-Ming
ZM
Wang
Environmental Simulation and Pollution Control State Key Joint Laboratory, State Environmental Protection Key Laboratory of Microorganism Application and Risk Control (SMARC), School of Environment, Tsinghua University, Beijing 100084, PR China; Shenzhen Laboratory of Microorganism Application and Risk Control, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, PR China.
Li-Xia
LX
Niu
Faculty of Science and Technology, Technological and Higher Education Institute of Hong Kong, Hong Kong, PR China.
Chao
C
Wang
Environmental Management Technology Research Institute, National Institute of Advanced Industrial Science and Technology, Onogawa 16-1, Tsukuba 305-8569, Japan; College of Architecture and Environment, Sichuan University, Chengdu 610065, Sichuan, PR China.
Ming-Chao
MC
Sun
Environmental Simulation and Pollution Control State Key Joint Laboratory, State Environmental Protection Key Laboratory of Microorganism Application and Risk Control (SMARC), School of Environment, Tsinghua University, Beijing 100084, PR China; Shenzhen Laboratory of Microorganism Application and Risk Control, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, PR China.
Hong-Ying
HY
Hu
D000327:Adsorption; D000998:Antiviral Agents / Q000737:chemistry*; D002264:Carboxylic Acids; D004785:Environmental Pollutants / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008962:Models, Theoretical; D037742:Nanotubes, Carbon / Q000737:chemistry*; D053139:Oseltamivir / Q000031:analogs & derivatives* / Q000737:chemistry
D000998:Antiviral Agents; D002264:Carboxylic Acids; D004785:Environmental Pollutants; D037742:Nanotubes, Carbon; D053139:Oseltamivir; C535162:oseltamivir carboxylate
Adsorption; Antiviral drug; Carbon nanotubes; Oseltamivir; Oseltamivir carboxylate