Prognostic value of CD44 expression in renal cell carcinoma: a systematic review and meta-analysis.
CD44 is a marker of cancer stem-like cells in renal cell carcinoma (RCC). However, the prognostic value of CD44 in RCC remains controversial. This study evaluated the correlation of CD44 expression with the clinicopathological features of RCC through a meta-analysis. We systematically searched PubMed, ISI Web of Science and Embase for relevant studies until February 2015. We collected and analysed data on clinical stage, Fuhrman grade, microvascular invasion, recurrence, five-year overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Twenty studies involving 1672 patients satisfied the inclusion criteria. Results showed that high CD44 expression in RCC was a poor prognostic marker for five-year OS (RR = 0.69, 95% CI 0.60-0.78) in a fixed-effects model and for five-year DSS (RR = 0.46, 95% CI 0.27-0.80) and five-year DFS (RR = 0.63, 95% CI 0.43-0.93) in a random-effects model. CD44 expression also correlated with Furhman grade (RR = 0.61, 95% CI 0.48-0.77), tumour recurrence (RR = 7.42, 95% CI 3.74-14.70) and MVI (Microvascular invasion) (RR = 3.63, 95% CI 1.97-6.71). This meta-analysis suggests that CD44 is a prognostic marker in RCC. High CD44 expression correlates with high Fuhrman grade, recurrence, MVI and poor prognosis.
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Xintao
X
Li
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Xin
X
Ma
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Luyao
L
Chen
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Liangyou
L
Gu
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Yu
Y
Zhang
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Fan
F
Zhang
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Yun
Y
Ouyang
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Yu
Y
Gao
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Qingbo
Q
Huang
Department of Urology, State Key Laboratory of Kidney Disease, PLA Medical School, Chinese People's Liberation Army General Hospital, Beijing, China.
Xu
X
Zhang
D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D017594:Publication Bias
D018960:Hyaluronan Receptors