Fatal co-infection with leptospirosis and dengue in a Sri Lankan male.
BACKGROUND
Leptospirosis and dengue are endemic in countries with subtropical or tropical climates and have epidemic potential. The incidence of both these diseases peaks during monsoons and both diseases present with similar clinical manifestations making differentiation of leptospirosis from dengue difficult. It is important to distinguish leptospirosis from dengue as early antibiotic therapy in leptospirosis leads to a favourable outcome, while dengue has no specific treatment, yet early recognition is vital for close monitoring and careful fluid management. Despite the high prevalence of both these infections, co-infection of leptospirosis and dengue has not been reported previously in Sri Lanka. We present the first case of co-infection with leptospirosis and dengue in a Sri Lankan male.


METHODS
A 52 year old previously healthy Sri Lankan male was admitted to our facility with a history of fever for 4 days associated with headache, generalized myalgia, reduced urine output. On examination, he was rational, hypotensive, tacycardic, tacypneic and he did not have clinical evidence of fluid leakage or pneumonitis. His serology showed high titre of dengue IgG and IgM and rising titre of leptospirosis antibody. His course of illness was complicated with septic shock, acute renal failure, acute respiratory distress syndrome and disseminated intravascular coagulation and he succumbed to his illness on the eighth day of admission.


CONCLUSIONS
In areas where both leptospirosis and dengue are endemic, both infections should be include in the differential diagnosis when evaluating patients with acute febrile illness and should consider the possibility of co-infection. Leptospirosis, being a condition having definitive antibiotic therapy, should always be ruled out even if the patient is positive for dengue serology in regions endemic to both these diseases as early initiation of antibiotic therapy can reduce mortality significantly.
National Hospital of Sri Lanka, Colombo, Sri Lanka. arunawijesinghe@gmail.com.
Aruna
A
Wijesinghe
National Hospital of Sri Lanka, Colombo, Sri Lanka. nveeravagu22@yahoo.com.
Nanthini
N
Gnanapragash
National Hospital of Sri Lanka, Colombo, Sri Lanka. ranasinghegayan@ymail.com.
Gayan
G
Ranasinghe
National Hospital of Sri Lanka, Colombo, Sri Lanka. muruguragu@gmail.com.
Murugapillai K
MK
Ragunathan
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D060085:Coinfection; D003715:Dengue / Q000097:blood / Q000150:complications*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005334:Fever / Q000175:diagnosis; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007922:Leptospirosis / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013188:Sri Lanka; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M