Facile Synthesis of 3-N-Alkyl Pyrimidin-2,4-diones from N-Sulfonyloxy Maleimides and Amines.
Reaction of variously substituted N-trifluoromethanesulfonyloxy maleimides with primary amines in the presence of potassium carbonate in DMF at room temperature results in the formation of 3-N-alkyl pyrimidin-2,4-diones in good yield.
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States.
Girish C
GC
Sati
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States.
David
D
Crich
D000588:Amines / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D008301:Maleimides / Q000737:chemistry*; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013463:Sulfuric Acid Esters / Q000737:chemistry*
D000588:Amines; D002254:Carbonates; D008301:Maleimides; D011744:Pyrimidinones; D013463:Sulfuric Acid Esters; C037593:potassium carbonate; D011188:Potassium