A critical role of toll-like receptor 2 (TLR2) and its' in vivo ligands in radio-resistance.
The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(-/-)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(-/-) mice. The cause of death in TLR2(-/-) mice may be severe and persistent bone marrow cell loss. Injection of the TLR2 agonist Pam3CSK4 into wild type (WT) mice induced radio-resistance. Myd88(-/-) mice were more susceptible to radiation. In conclusion, our data indicate that, similar to TLR4, TLR2 plays a critical role in radio-resistance.
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Fu
F
Gao
Department of Centre for Disease Prevention and Control, Chengdu Military Region, Chengdu 610021, China.
Chaoxiong
C
Zhang
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Chuanfeng
C
Zhou
National Key Laboratory of Medical Immunology&Institute of Immunology, Second Military Medical University, Shanghai 200433, China.
Weimin
W
Sun
Model Animal Research Center, Nanjing University, Nanjing, People's Republic of China.
Xin
X
Liu
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Pei
P
Zhang
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Jiaqi
J
Han
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Linfeng
L
Xian
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Dongchen
D
Bai
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Hu
H
Liu
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Ying
Y
Cheng
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Bailong
B
Li
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Jianguo
J
Cui
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Jianming
J
Cai
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China.
Cong
C
Liu
D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology / Q000528:radiation effects*; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage; D051379:Mice; D018345:Mice, Knockout; D011836:Radiation Tolerance / Q000187:drug effects / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000819:agonists / Q000235:genetics*
D055666:Lipopeptides; C508075:Pam(3)CSK(4) peptide; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2