The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity.
Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.
Vascular Biology Center, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, United States. Electronic address: Jthompson2@gru.edu.
Jennifer A
JA
Thompson
Department of Physiology, Georgia Regents University, United States.
Trevor A
TA
Hardigan
Department of Physiology, Georgia Regents University, United States.
Maria Alicia
MA
Carrillo-Sepulveda
Vascular Biology Center, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, United States.
James D
JD
Mintz
Department of Physiology, Georgia Regents University, United States.
Adviye
A
Ergul
Department of Obstetrics and Gynecology, Georgia Regents University, United States.
Michael P
MP
Diamond
Department of Physiology, Georgia Regents University, United States.
R Clinton
RC
Webb
D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects; D005260:Female; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D010168:Palmitates / Q000009:adverse effects; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D051193:Toll-Like Receptors / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D010168:Palmitates; D051193:Toll-Like Receptors; D014409:Tumor Necrosis Factor-alpha
Maternal obesity; Placental inflammation; Toll-like receptors