The application of antitumor drug-targeting models on liver cancer.
Hepatocarcinoma animal models, such as the induced tumor model, transplanted tumor model, gene animal model, are significant experimental tools for the evaluation of targeting drug delivery system as well as the pre-clinical studies of liver cancer. The application of antitumor drug-targeting models not only furnishes similar biological characteristics to human liver cancer but also offers guarantee of pharmacokinetic indicators of the liver-targeting preparations. In this article, we have reviewed some kinds of antitumor drug-targeting models of hepatoma and speculated that the research on this field would be capable of attaining a deeper level and expecting a superior achievement in the future.
a School of Pharmacy, Xi'an Jiaotong University , Xi'an , Shaanxi , China .
Yan
Y
Yan
b Surgical Department of Emergency Center, The People's Hospital of Sichuan Province , Sichuan , China and.
Ningbo
N
Chen
c National Engineering Research Center in Biomaterials, Sichuan University , Chengdu , Sichuan , China.
Yunbing
Y
Wang
a School of Pharmacy, Xi'an Jiaotong University , Xi'an , Shaanxi , China .
Ke
K
Wang
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000473:pathology*; D016503:Drug Delivery Systems; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology*
D000970:Antineoplastic Agents
Animal models; antitumor drugs; gene knock-out; liver cancer; targeting agents