The neurotoxicology of uranium.
The brain is a target of environmental toxic pollutants that impair cerebral functions. Uranium is present in the environment as a result of natural deposits and release by human applications. The first part of this review describes the passage of uranium into the brain, and its effects on neurological functions and cognitive abilities. Very few human studies have looked at its cognitive effects. Experimental studies show that after exposure, uranium can reach the brain and lead to neurobehavioral impairments, including increased locomotor activity, perturbation of the sleep-wake cycle, decreased memory, and increased anxiety. The mechanisms underlying these neurobehavioral disturbances are not clearly understood. It is evident that there must be more than one toxic mechanism and that it might include different targets in the brain. In the second part, we therefore review the principal mechanisms that have been investigated in experimental models: imbalance of the anti/pro-oxidant system and neurochemical and neurophysiological pathways. Uranium effects are clearly specific according to brain area, dose, and time. Nonetheless, this review demonstrates the paucity of data about its effects on developmental processes and the need for more attention to the consequences of exposure during development.
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Pôle de la Radioprotection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale, BP 17, F-92262 Fontenay-aux-Roses, France. Electronic address: celine.dinocourt@irsn.fr.
Céline
C
Dinocourt
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Pôle de la Radioprotection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale, BP 17, F-92262 Fontenay-aux-Roses, France. Electronic address: marie.legrand@irsn.fr.
Marie
M
Legrand
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Pôle de la Radioprotection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale, BP 17, F-92262 Fontenay-aux-Roses, France. Electronic address: isabelle.dublineau@irsn.fr.
Isabelle
I
Dublineau
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Pôle de la Radioprotection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale, BP 17, F-92262 Fontenay-aux-Roses, France. Electronic address: philippe.lestaevel@irsn.fr.
Philippe
P
Lestaevel
D000818:Animals; D001519:Behavior / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000473:pathology* / Q000523:psychology*; D014501:Uranium / Q000493:pharmacokinetics / Q000633:toxicity*; D017974:Uranium Compounds / Q000493:pharmacokinetics / Q000633:toxicity*
D017974:Uranium Compounds; D014501:Uranium
Cognition; Locomotion; Neurophysiology; Oxidative stress; Sleep; Uranyl