Catalyst-Controlled, Regioselective Reactions of Carbohydrate Derivatives.
Carbohydrates generally possess multiple hydroxyl groups of similar reactivity, and selective monofunctionalization is often difficult. Catalysis provides a versatile and potentially general solution to this problem. This chapter provides an overview of catalyst-controlled methods for the regioselective activation of carbohydrate derivatives. The catalysts discussed include organocatalysts (Lewis bases, Brønsted acids/bases, and others) as well as those based on main group and transition metal elements.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada, M5S 3H6. mtaylor@chem.utoronto.ca.
Mark S
MS
Taylor
Carbohydrates; Catalysis; Glycosylation; Lewis acids; Lewis bases; Organocatalysis; Protective groups; Regioselectivity