Voltage-responsive reversible self-assembly and controlled drug release of ferrocene-containing polymeric superamphiphiles.
A new type of voltage-responsive comb-like superamphiphilic block polymer PEG113-b-PAA30/FTMA was prepared by the electrostatic interactions of an ionic ferrocenyl surfactant (FTMA) and an oppositely charged double-hydrophilic block polyelectrolyte poly-(ethylene glycol)-b-poly(acrylic acid) (PEG113-b-PAA30) in aqueous solution. An in situ electrochemical redox system was designed to research its electrochemical activity in aqueous solution. The polymeric superamphiphile PEG113-b-PAA30/FTMA could reversibly aggregate to form spherical micelles of 20-30 nm diameter in aqueous solution, and also disaggregate into irregular fragments by an electrochemical redox reaction when its concentration is in the range of the critical aggregation concentration (cacred) of the reduction state to its cacox of the oxidation state. Interestingly, above cacox, the superamphiphile can aggregate into spherical micelles of 20-30 nm diameter, which can be transformed into larger spherical micelles of 40-120 nm diameter after electrochemical oxidation, and reversibly recover initial sizes after electrochemical reduction. Moreover, this reversible self-assembly process can be electrochemically controlled just by changing its electrochemical redox extent without adding any other chemical reagent. Further, rhodamine 6G (R6G)-loaded polymeric superamphiphile aggregates have been successfully used for the voltage-controlled release of loaded molecules based on their voltage-responsive self-assembly, and the release rate of R6G could be mediated by changing electrochemical redox potentials and the concentrations of polymeric superamphiphiles. Our observations witness a new strategy to construct a voltage-responsive reversible self-assembly system.
Research Institute of Materials Science and, The Key Laboratory of Polymer Processing Engineering, Ministry of Education, South China University of Technology, Guangzhou 510641, China. mcbyren@scut.edu.cn.
Xueyi
X
Chang
Zhiyu
Z
Cheng
Biye
B
Ren
Renfeng
R
Dong
Jun
J
Peng
Shiyu
S
Fu
Zhen
Z
Tong
D000180:Acrylic Resins / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D065546:Drug Liberation; D004560:Electricity; D055664:Electrochemical Techniques; D005296:Ferrous Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000008:administration & dosage; D000075163:Metallocenes; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry*; D012235:Rhodamines / Q000008:administration & dosage; D013501:Surface-Active Agents / Q000737:chemistry*
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005296:Ferrous Compounds; D005456:Fluorescent Dyes; D000075163:Metallocenes; D012235:Rhodamines; D013501:Surface-Active Agents; C026188:rhodamine 6G; D011092:Polyethylene Glycols; C006903:carbopol 940; C004998:ferrocene