Advances in functional neurosurgery for Parkinson's disease.
Functional neurosurgery for Parkinson's disease has become a mainstream concept with DBS as the prime modality. This article reviews the latest and, in the eyes of the authors, the most important developments in DBS, lesioning and gene therapy. In DBS, emerging advances have focused on the timing of surgery relative to disease duration and severity, and new targets, technologies, and equipment. For lesions, new ultrasound techniques are emerging based on successes in other movement disorders. Gene and cellular therapies, including stem cells, remain only in the research realm.
Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.
Leo Verhagen
LV
Metman
Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, USA.
Konstantin V
KV
Slavin
D001921:Brain / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures / Q000379:methods*; D010300:Parkinson Disease / Q000628:therapy*; D014057:Tomography, X-Ray Computed
DBS; Parkinson; closed loop; current steering; focused ultrasound; frameless; functional neurosurgery; gene therapy; intra-operative CT; intra-operative MRI; surgery