Cortical and subcortical glutathione levels in adults with autism spectrum disorder.
Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men.
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Alice M S
AMS
Durieux
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Jamie
J
Horder
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
M Andreina
MA
Mendez
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Alice
A
Egerton
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Steven C R
SCR
Williams
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
C Ellie
CE
Wilson
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Debbie
D
Spain
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Clodagh
C
Murphy
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Dene
D
Robertson
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Gareth J
GJ
Barker
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Declan G
DG
Murphy
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Grainne M
GM
McAlonan
D000293:Adolescent; D000328:Adult; D000067877:Autism Spectrum Disorder / Q000000981:diagnostic imaging / Q000378:metabolism*; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D011522:Protons; D055815:Young Adult
D011522:Protons; D005978:Glutathione
autism; glutathione; magnetic resonance spectroscopy; oxidative stress; redox