Disabling amnestic syndrome following stereotactic laser ablation of a hypothalamic hamartoma in a patient with a prior temporal lobectomy.
A 19-year-old man with cortical dysplasia and intractable focal seizures underwent a right temporal lobectomy. A hypothalamic hamartoma was subsequently recognized, and he then underwent MRI-guided stereotactic laser ablation. Unfortunately, he sustained damage to the bilateral medial mammillary bodies and suffered significant memory loss. We review laser ablation therapy for hypothalamic hamartomas and the anatomy of the memory network. We postulate that his persistent memory disorder resulted from a combination of the right temporal lobectomy and injury to the bilateral medial mammillary bodies.
NYU Langone Medical Center, New York, NY 10016, USA.
Sarah
S
Zubkov
Ferkauf Graduate School of Psychology, Yeshiva University, 1165 Morris Park Avenue, Bronx, NY 10461, USA.
Victor A
VA
Del Bene
NYU Langone Medical Center, New York, NY 10016, USA.
William S
WS
MacAllister
NYU Langone Medical Center, New York, NY 10016, USA.
Timothy M
TM
Shepherd
NYU Langone Medical Center, New York, NY 10016, USA.
Orrin
O
Devinsky
Anterograde amnesia; Epilepsy surgery; Hypothalamic hamartoma; MRI-guided stereotactic laser ablation; Mammillary bodies