Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population.
Our results showed that, at the same BMI level, Uygurs have greater WHR values, abdominal visceral fat content, and diabetes risks than Kazaks. In addition, values of HDL-C in Uygur subjects were lower than those in Kazak subjects, and values of creatinine, uric acid, diastolic blood pressure, blood glucose, and fructosamine in Uygur male subjects were lower than those in Kazak male subjects. In contrast, systolic blood pressure values in Uygur subjects were greater than those in Kazak subjects, and blood glucose values were greater in Uygur female subjects than in Kazak female subjects. Additionally, in Uygurs, visceral adipose tissue expression levels of TBX1 and TCF21 were greater in obesity group than in normal and T2DM groups and lower in T2DM group than in normal group (P < 0.01). The visceral adipose tissue expression levels of APN in normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels of TNF-α and MCP-1 in normal group were lower than those in obesity and T2DM groups (P < 0.01). In conclusion, T2DM in Uygurs was mainly associated with not only distribution of adipose tissue in body, but also change in metabolic activity and adipocytokines secretion of adipose tissue.
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Jun
J
Zhang
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Zhiwei
Z
Zhang
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Yulei
Y
Ding
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Peng
P
Xu
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Tingting
T
Wang
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Wenjing
W
Xu
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Huan
H
Lu
Department of Endocrinology and Metabolism, First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
Jun
J
Li
Endocrinology Department of Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
Yan
Y
Wang
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Siyuan
S
Li
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Zongzhi
Z
Liu
Department of Endocrinology, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
Na
N
An
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Li
L
Yang
School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, China.
Jianxin
J
Xie
D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001823:Body Composition; D015992:Body Mass Index; D002681:China; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000473:pathology; D005260:Female; D019270:Fructosamine / Q000097:blood; D020869:Gene Expression Profiling; D006801:Humans; D050152:Intra-Abdominal Fat / Q000473:pathology; D007623:Kazakhstan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology* / Q000473:pathology; D060888:Real-Time Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D014409:Tumor Necrosis Factor-alpha; D014527:Uric Acid; D019270:Fructosamine; D003404:Creatinine