Patch Testing with Dental Screening Series in Oral Disease.
BACKGROUND
The oral mucosa is constantly exposed to several irritants and allergens including dental materials, but the role of contact allergy in oral disease is obscure.


OBJECTIVE
To analyze positive patch test results in patients with oral diseases and evaluate the clinical relevance of oral diseases with contact allergy to dental materials.


METHODS
We retrospectively analyzed patch test results with dental screening series in 44 patients with oral disease from 2004~2011.


RESULTS
Oral diseases included oral lichen planus (54.5%), cheilitis (27.3%), burning mouth syndrome (9.1%), and others (9.1%). Thirty-one of 44 patients (70.5%) had positive reactions to one or more allergens. The most commonly detected allergens were gold sodium thiosulfate (25.0%) and nickel sulfate (25.0%), followed by potassium dichromate (22.7%), cobalt (15.9%), palladium (6.8%), mercury (4.5%), copper (4.5%), and methylhydroquinone (4.5%). Six of 24 patients with oral lichen planus had a symptom in areas adjacent to dental materials and positive patch test reactions to allergens contained in the suspected dental materials.


CONCLUSIONS
Patch tests with dental screening series are worth considering for oral diseases, especially for oral lichen planus.
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
Tae-Wook
TW
Kim
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Woo-Il
WI
Kim
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
Je-Ho
JH
Mun
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
Margaret
M
Song
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
Hoon-Soo
HS
Kim
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Bio-Medical Research Institute, Pusan National University Hospital, Busan, Korea.
Byung-Soo
BS
Kim
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Bio-Medical Research Institute, Pusan National University Hospital, Busan, Korea.
Moon-Bum
MB
Kim
Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea. ; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Hyun-Chang
HC
Ko
Dental materials; Dental screening series; Oral disease; Patch tests