Recent trends in the development of vitamin B12 derivatives for medicinal applications.
This Feature Article highlights recent developments in the field of vitamin B12 derivatives for medicinal applications. The following topics are emphasized: (1) the development of aquacorrinoids for cyanide detection and detoxification, (2) the use of vitamin B12 conjugates and (3) antivitamins B12 for therapy and diagnosis, and (4) the design of corrinoids as activators of soluble guanylyl cyclase (sGC).
Department of Chemistry, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland. felix.zelder@chem.uzh.ch.
Felix
F
Zelder
D055808:Drug Discovery / Q000639:trends*; D015394:Molecular Structure; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use*
D014805:Vitamin B 12