[TRIGLYCERIDE LEVELS AS A RISK FACTOR DURING PREGNANCY; BIOLOGICAL MODELING; SYSTEMATIC REVIEW].
BACKGROUND
introduction: Some of the diseases that can appear in pregnancy (gestational diabetes, hypertension and preeclampsia) are being associated with an increased risk of heart throughout life diseases. This should be present in future assessments of the health of women. One of the most important biomarkers in cardiovascular diseases is the triglyceride level, and that undergoes a significant change during pregnancy.


OBJECTIVE
the objective of this review is to analyze the studies that have investigated triglyceride levels during pregnancy as a risk factor for cardiovascular disease in the last weeks of pregnancy and childbirth.


METHODS
a systematic search was made and 14 specific articles on the subject were selected following the PRISMA guidelines.


RESULTS
in normal pregnancy decreased the level of lipids in the first weeks, followed by a gradual increase. Especially high from the 12th week of gestation. This increase in plasma levels of circulating lipids occurs linearly, reaching a peak a few days before delivery. This increase results because of the increased estrogen levels and insulin resistance. It has also been associated with prolactin levels.


CONCLUSIONS
through this review, it has been able to demonstrate the relationship of elevated triglycerides some pathologies or more frequent changes in risk pregnancies, in which a significantly higher elevation occurs compared to normal pregnancies. It is in this context that the biological modeling may be particularly important, facilitating the creation of models and percentile curves applicable to the population, and allow monitoring of changes in triglycerides, which end up pointing situations passing be predictors of a potentially pathological situation. Thus, appropriate interventions would be carried rafter more briefly, and see so favored adequate primary prevention.
Departamento de Enfermería. Facultad de Ciencias de la Salud. Universidad de Granada. Hospital Clínico San Cecilio de Granada, España.. mariajaguilar@telefonica.net.
María José
MJ
Aguilar Cordero
Grupo de Investigación CTS 367. Plan Andaluz de Investigación. Junta de Andalucía. Departamento de Enfermería. Universidad de Granada, España.. mariajaguilar@telefonica.net.
Laura
L
Baena García
Grupo de Investigación CTS 367. Plan Andaluz de Investigación. Junta de Andalucía. Departamento de Enfermería. Universidad de Granada, España.. mariajaguilar@telefonica.net.
Antonio Manuel
AM
Sánchez López
Departamento de Enfermería. Facultad de Ciencias de la Salud. Universidad de Granada. Hospital Clínico San Cecilio de Granada, España.. mariajaguilar@telefonica.net.
Rafael
R
Guisado Barrilao
Departamento de Enfermería. Universidad de Granada, España.. mariajaguilar@telefonica.net.
Enrique
E
Hermoso Rodríguez
Grupo de Investigación CTS 367. Plan Andaluz de Investigación. Junta de Andalucía, España. Facultad de Ciencias Médicas de Cienfuegos, Cuba.. mariajaguilar@telefonica.net.
Norma
N
Mur Villar
Departamento de Lenguajes y Sistemas Informáticos. ETS Ingenierías Informática y Telecomunicación (ETSIIT). Universidad de Granada, España.. mariajaguilar@telefonica.net.
Manuel
M
Capel Tuñón
D000328:Adult; D015415:Biomarkers; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008954:Models, Biological; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood; D011263:Pregnancy Trimester, Third; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
D015415:Biomarkers; D004967:Estrogens; D008055:Lipids; D014280:Triglycerides