The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population.
OBJECTIVE
To investigate the effect of silent information regulator 1 (SIRT1) gene polymorphisms on ambulatory blood pressure in hypertensive patients.


METHODS
Three hundred forty hypertensive patients were recruited from January 2013 to January 2015. SIRT1 Tag single-nucleotide polymorphisms (SNPs; rs2273773, rs4746720, and rs7896005) were genotyped using a PCR-direct sequencing method, and the association between the SIRT1 gene SNPs and ambulatory blood pressure was analyzed.


RESULTS
After adjusting for confounding factors, patients with the rs2273773/CT+CC genotypes had lower 24-h systolic and diastolic blood pressures; there were no associations between rs4746720 and rs7896005 genotypes and blood pressure.


CONCLUSIONS
The SIRT1 gene polymorphism (rs2273773) is significantly associated with ambulatory blood pressure level in Han Chinese patients with hypertension.
1 Department of Cardiology, The Second Affiliated Hospital of Xinjiang Medical University , Urumqi, China .
Xiao-Lan
XL
Zhong
2 No. 1 Department of Cadre Ward, The First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .
Hai-Jun
HJ
Miao
1 Department of Cardiology, The Second Affiliated Hospital of Xinjiang Medical University , Urumqi, China .
Zhi-Min
ZM
Fang
1 Department of Cardiology, The Second Affiliated Hospital of Xinjiang Medical University , Urumqi, China .
Bannu
B
Kuken
1 Department of Cardiology, The Second Affiliated Hospital of Xinjiang Medical University , Urumqi, China .
Hong-Yan
HY
Song
3 Catheterization Laboratory, The Second Affiliated Hospital of Xinjiang Medical University , Urumqi, China .
Hua
H
Zhong
1 Department of Cardiology, The Second Affiliated Hospital of Xinjiang Medical University , Urumqi, China .
Yun
Y
Lu
1 Department of Cardiology, The Second Affiliated Hospital of Xinjiang Medical University , Urumqi, China .
Shun-Min
SM
Liu
D000328:Adult; D000368:Aged; D044466:Asian People; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D056564:Sirtuin 1 / Q000235:genetics*
C447939:SIRT1 protein, human; D056564:Sirtuin 1