An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug.
We reported a novel injectable doxorubicin-loaded hydrogel based on host-guest interaction and Schiff's base reaction. A supramolecular polymeric prodrug was prepared through the inclusion of adamantane-modified doxorubicin into the β-cyclodextrin cavity on the polyaldehyde dextran chain, which was in situ crosslinked by carboxymethyl chitosan.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China. zhuwp@zju.edu.cn.
Lu
L
Xiong
Qiaojie
Q
Luo
Ying
Y
Wang
Xiaodong
X
Li
Zhiquan
Z
Shen
Weipu
W
Zhu
D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; D011355:Prodrugs; D047392:beta-Cyclodextrins; D004317:Doxorubicin; C031215:betadex