Quinoxalines Potential to Target Pathologies.
The study of quinoxalines has increased immeasurably during the last two decades, due firstly to their relatively simple chemical synthesis, which has generated a vast variety of compounds with diverse structural modifications, and secondly, to the wide therapeutic potential and biological activities exhibited by this family of compounds. Quinoxalines constitute a rising biomedical class of low-molecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory, antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents, as well as being of interest for the potential treatment of glaucoma, insomnia, cardiovascular and neurological diseases, among others. However, a deeper knowledge of the molecular targets of quinoxalines that fulfil a key role in certain pathologies is required for the development of new and more specific drugs through a rational design strategy to avoid undesirable side effects. In the present review, we summarize the most important molecular targets of the quinoxaline derivatives discovered to date, thus providing a first reference index for researchers to identify the potential targets of their quinoxalines derived collections, which could facilitate the development of new quinoxaline- based therapies.
María
M
Tristán-Manzano
Antonio
A
Guirado
María
M
Martínez-Esparza
Jesús
J
Gálvez
Pilar
P
García-Peñarrubia
Department of Biochemistry, Molecular Biology B and Immunology, Faculty of Medicine, Murcia University, 30100 Murcia, Spain. ajruiz@um.es.
Antonio J
AJ
Ruiz-Alcaraz
D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D011810:Quinoxalines / Q000494:pharmacology* / Q000627:therapeutic use
D011810:Quinoxalines