[A nested case-control study on the relationship of three kinds of cytokines and risk of cardio-cerebrovascular events among Inner Mongolians].
OBJECTIVE
To investigate the relationship between homocysteine (Hcy), von willebrand factor (vWF), soluble intercellular adhesion molecule-1 (sICAM-1) and the risk of cardio-cerebrovascular events among Inner Mongolians.


METHODS
A survey was conducted among 2 589 Inner Mongolians from May 2002 to June 2003, and they were followed up for about ten years. The 182 individuals who developed cardio-cerebrovascular events in the cohort were defined as cases and those whose age, gender and residence 1:1 matched to cases were selected from the individuals who did not developed cardio-cerebrovascular events as controls. Then, a nested case-control study was used to analyze the relationship between Hcy, vWF and sICAM-1 and risk of cardio-cerebrovascular events. Conditonallogistic regression analysis was used to calculate OR values and 95% CI.


RESULTS
The cases had a higher baseline blood pressure, higher prevalence of hypertension and family history of hypertension compared to controls (all P values < 0.05), however, there were no significantly different between TC, TG, LDL-C, HDL-C, FBG, smoking and drinking rates (all P values > 0.05). The M (P(25)-P(75)) of Hcy were 10.68 (7.84-14.98) and 10.02 (6.64-13.94) µmol/L, vWFs were 10.88 (8.14-14.58) and 10.42 (7.97-13.50) mg/L, sICAM-1 were 336.48 (260.68-409.87) and 335.12 (269.87-409.87) ng/ml. They were not significantly different between the two groups (Z values were 0.89, 0.94 and 0.29, respectively, all P values >0.05). After adjustment for the family history of hypertension, hypertension, TC, FPG, BMI, smoking and drinking rate, the conditional logistic regression showed that OR (95% CI) of risk of cardio-cerebrovascular events were 1.00 (0.52-1.93), 2.37 (1.25-4.49), and 0.81 (0.45-1.47) for the participants with increased Hcy, vWF, and sICAM-1, compared with those with normal Hcy, vWF, and sICAM-1, respectively.


CONCLUSIONS
In the Inner Mongolians, increased vWF at baseline may increase the risk of cardio-cerebrovascular events, and increased Hcy and sICAM-1 were not significantly associated with the risk of cardio-cerebrovascular events.
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Yan
Y
Liu
Xiaoqing
X
Bu
Qiuyan
Q
Chen
Juan
J
Xu
Fanlong
F
Kong
Guiyan
G
Wang
Email: yhzhang@suda.edu.cn.
Yonghong
Y
Zhang
D002318:Cardiovascular Diseases; D016022:Case-Control Studies; D016207:Cytokines; D006710:Homocysteine; D006801:Humans; D006973:Hypertension; D018799:Intercellular Adhesion Molecule-1; D016015:Logistic Models; D015995:Prevalence; D012306:Risk; D012307:Risk Factors; D020521:Stroke; D014841:von Willebrand Factor
D016207:Cytokines; D014841:von Willebrand Factor; D006710:Homocysteine; D018799:Intercellular Adhesion Molecule-1