Cell traction in collective cell migration and morphogenesis: the chase and run mechanism.
Directional collective cell migration plays an important role in development, physiology, and disease. An increasing number of studies revealed key aspects of how cells coordinate their movement through distances surpassing several cell diameters. While physical modeling and measurements of forces during collective cell movements helped to reveal key mechanisms, most of these studies focus on tightly connected epithelial cultures. Less is known about collective migration of mesenchymal cells. A typical example of such behavior is the migration of the neural crest cells, which migrate large distances as a group. A recent study revealed that this persistent migration is aided by the interaction between the neural crest and the neighboring placode cells, whereby neural crest chase the placodes via chemotaxis, but upon contact both populations undergo contact inhibition of locomotion and a rapid reorganization of cellular traction. The resulting asymmetric traction field of the placodes forces them to run away from the chasers. We argue that this chase and run interaction may not be specific only to the neural crest system, but could serve as the underlying mechanism for several morphogenetic processes involving collective cell migration.
a Department of Cell and Developmental Biology ; University College London ; London UK.
András
A
Szabó
a Department of Cell and Developmental Biology ; University College London ; London UK.
Roberto
R
Mayor
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002633:Chemotaxis; D004848:Epithelium / Q000378:metabolism; D008648:Mesoderm / Q000378:metabolism; D009024:Morphogenesis / Q000502:physiology*; D009432:Neural Crest / Q000166:cytology*
N-Cadherin; Rac1; cell traction; chemotaxis; collective cell migration; contact inhibition of locomotion; mesenchymal cell migration; morphogenesis; neural crest; placodes