Endothelial Changes in Individuals with Prehypertension.
Prehypertension is considered a precursor of systemic arterial hypertension and a predictor of morbidity-mortality due to cardiovascular diseases, which are the main causes of death in Brazil and the world. Thus, early diagnosis and the adoption of therapeutic measures in cases of prehypertension can reduce cardiovascular risk. The aim of the present study was to perform a selective review of the literature to identify and discuss early endothelial changes in individuals with pre-hypertension.



The findings indicate an increase in ET-1-mediated vasoconstrictor tone in prehypertension, with endothelial-dependent vasodilatation impairment. Moreover, significantly high levels of angiotensin, arginine and vasopressin were found in this group of patients. A reduction in endothelial fibrinolytic capacity was another important change found in patients with prehypertention and was associated with an increased risk for atherothrombotic events.



The present findings demonstrate endothelial changes in individuals with prehypertension that contribute to the development of arterial hypertension as well as a high risk for cardiovascular events, underscoring the importance of the early adoption of optimized therapeutic measures for this population.
Department of Physical Therapy, Medical School of Sao Jose do Rio Preto (FAMERP), Av. Brg. Faria Lima, 5416 - Vila Sao Pedro, São José do Rio Preto - SP, 15090-000, Brazil. flaviamvalente@hotmail.com.
Flavia Mariana
FM
Valente
Patricia
P
Vespasiano
Juliana Aparecida
JA
Barbosa
Claudia Bernardi
CB
Cesarino
Days Oliveira
DO
de Andrade
Leticia Aparecida
LA
Barufi Fernandes
Luciana Neves
LN
Cosenso-Martin
Alessandra Beatriz
AB
Balduino-Mendes
Camila
C
Gaglianone
José Fernando
JF
Vilela-Martin
D001938:Brazil; D002318:Cardiovascular Diseases / Q000209:etiology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D058246:Prehypertension / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D012307:Risk Factors; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology