Genes and environment as predisposing factors in autoimmunity: acceleration of spontaneous thyroiditis by dietary iodide in NOD.H2(h4) mice.
In the field of autoimmune thyroiditis, NOD.H2(h4) mice have attracted significant and increasing attention since they not only develop spontaneous disease but they present thyroiditis with accelerated incidence and severity if they ingest iodide through their drinking water. This animal model highlights the interplay between genetic and dietary factors in the triggering of autoimmune disease and offers new opportunities to study immunoregulatory parameters influenced by both genes and environment. Here, we review experimental findings with this mouse model of thyroiditis.
a Division of Biomedical Sciences , Memorial University of Newfoundland , St. John's , NL , Canada.
Panayota
P
Kolypetri
a Division of Biomedical Sciences , Memorial University of Newfoundland , St. John's , NL , Canada.
Justin
J
King
a Division of Biomedical Sciences , Memorial University of Newfoundland , St. John's , NL , Canada.
Mani
M
Larijani
a Division of Biomedical Sciences , Memorial University of Newfoundland , St. John's , NL , Canada.|b Division of Endocrinology, Faculty of Medicine , Memorial University of Newfoundland , St. John's , NL , Canada.
George
G
Carayanniotis
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D019587:Dietary Supplements / Q000009:adverse effects; D004195:Disease Models, Animal; D004777:Environment; D015870:Gene Expression; D059647:Gene-Environment Interaction; D006801:Humans; D007454:Iodides / Q000009:adverse effects; D051379:Mice; D016688:Mice, Inbred NOD; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000209:etiology / Q000378:metabolism / Q000473:pathology
D001323:Autoantibodies; D016207:Cytokines; D007454:Iodides; D013954:Thyroglobulin
NOD.H2h4 mice; iodine; thyroglobulin; thyroiditis