Eco-Friendly Synthesis of a New Class of Pyridinium-Based Ionic Liquids with Attractive Antimicrobial Activity.
The present study reports a green synthesis of a new family of ionic liquids (ILs) based on functionalized 4-dimethylaminopyridinium derivatives. The structures of 23 newly synthesized ILs (2-24) were confirmed by FT-IR, (1)H-, (13)C-, (11)B-, (19)F-, and (31)P-NMR spectroscopy and mass spectrometry. The antimicrobial activity of all novel ILs was tested against a panel of bacteria and fungi. The results prove that all tested ILs are effective antibacterial and antifungal agents, especially 4-(dimethylamino)-1-(4-phenoxybutyl) pyridinium derivatives 5 and 19.
Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia. mouslim@mail.be.
Mouslim
M
Messali
D000478:Alkylation; D000838:Anions; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D055772:Green Chemistry Technology / Q000379:methods*; D052578:Ionic Liquids / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D014465:Ultrasonics
D000838:Anions; D000890:Anti-Infective Agents; D052578:Ionic Liquids; D011726:Pyridinium Compounds
antimicrobial activity; eco-friendly synthesis; ionic liquid; ultrasound irradiation