Bacillus cereus Cerebral Abscess During Induction Chemotherapy for Childhood Acute Leukemia.
A 5-year-old boy with standard-risk B-cell acute lymphoblastic anemia developed fever during induction chemotherapy. The patient had no neurological symptoms. Blood cultures grew Bacillus cereus and neuroimaging studies demonstrated a cerebral abscess. Imaging changes resolved after completion of antibiotics. Bacillus cereus bacteremia is increasingly implicated as the cause of life-threatening infections, including cerebral abscesses, in compromised patients. Positive blood cultures for this organism should prompt neuroimaging and consideration of cerebrospinal fluid sampling, as well as catheter removal. Given the worse outcome with central nervous system involvement, there is a need for increased awareness and early diagnosis, particularly in immunocompromised individuals.
*Department of Neurology, Boston Children's Hospital †Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute, Boston, MA.
Gabriel
G
Dabscheck
Lewis
L
Silverman
Nicole J
NJ
Ullrich
D001409:Bacillus cereus; D001922:Brain Abscess / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D002675:Child, Preschool; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000209:etiology* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D060828:Induction Chemotherapy / Q000009:adverse effects*; D015448:Leukemia, B-Cell / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male