Adiponectin and leptin gene polymorphisms in patients with post-transplant diabetes mellitus.
BACKGROUND
Post-transplant diabetes mellitus (PTDM) is a common metabolic complication after organ transplantation and may be associated with the use of calcineurin inhibitors (tacrolimus and cyclosporine). Leptin and adiponectin are adipokines and play an important role in the regulation of insulin secretion as well as glucose and lipid metabolism.


OBJECTIVE
The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and development of PTDM.


METHODS
The study included 323 patients who received kidney transplants and were treated with calcineurin inhibitors (tacrolimus or cyclosporine).


RESULTS
The association between adiponectin and leptin gene polymorphisms and PTDM was studied in three models of Cox regression analysis--additive, dominant and recessive. In these three models, the LEP rs2167270 gene polymorphism was statistically significantly associated with increased risk of PTDM. The association between the LEP rs2167270 polymorphism and PTDM was confirmed by multivariate regression analysis.


CONCLUSIONS
The results of our study suggest an association between the leptin rs2167270 gene A allele and PTDM. Original submitted 27 February 2015; Revision submitted 22 May 2015.
Department of General & Transplantation Surgery, Pomeranian Medical University, Szczecin, Poland.
Maciej
M
Romanowski
Department of Biochemistry & Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Violetta
V
Dziedziejko
Faculty of Physical Education & Health Promotion, University of Szczecin, Szczecin, Poland.
Agnieszka
A
Maciejewska-Karlowska
Faculty of Physical Education & Health Promotion, University of Szczecin, Szczecin, Poland.
Marek
M
Sawczuk
Department of Biochemistry & Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Krzysztof
K
Safranow
Clinical Department of Nephrology, Transplantology & Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
Leszek
L
Domanski
Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
Andrzej
A
Pawlik
D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D000483:Alleles; D016572:Cyclosporine / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D020738:Leptin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D011183:Postoperative Complications / Q000453:epidemiology / Q000235:genetics; D012306:Risk; D016559:Tacrolimus / Q000627:therapeutic use
C499918:ADIPOQ protein, human; D052242:Adiponectin; D007166:Immunosuppressive Agents; D020738:Leptin; D016572:Cyclosporine; D016559:Tacrolimus
adiponectin; calcineurin inhibitors; graft; kidney; leptin; polymorphism; post-transplant diabetes mellitus