[DYNAMICS OF APOPTOTIC MARKERS (INTERLEUKIN-2 AND TNF-α) IN THE BLOOD SERUM OF CHILDREN WITH CHRONIC GASTRODUODENITES].
The aim was to investigate apoptotic dynamics by IL-2 and TNF-α levels in the blood serum of children with chronic gastroduodenites.


METHODS
There were examined 90 children with chronic gastroduodenitis. Cytokine level in the serum was studied at admission and in dynamics.


RESULTS
Chronic gastroduodenitis is accompanied by the increase of IL-2 and TNF-α concentration thus reflecting the activity of apoptotic processes. The decrease of the markers' (IL-2 and TNF-α) levels after 10-11 days, 3 and 9 months after treatment indicates the decrease of apoptotic activity. In hyperplastic and atrophic gastritis there has been registered the highest and the lowest concentration of the markers, respectively. H. pylori contributes to the TNF-α production mainly.
E Yu
EY
Reuka
V D
VD
Trifonov
Yu V
YV
Chernenkov
T V
TV
Rodionova
D015415:Biomarkers / Q000097:blood; D002648:Child; D002908:Chronic Disease; D004382:Duodenitis / Q000097:blood*; D005260:Female; D005759:Gastroenteritis / Q000097:blood*; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015415:Biomarkers; C508594:IL2 protein, human; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha