Pervasive refusal syndrome - A clinical challenge.
Pervasive refusal syndrome is described as a condition comprising varying degrees of refusal across several domains; social withdrawal; resistance to treatment and is potentially life threatening with no detectable organic cause. Female predominance, refusal to eat with low weight, body image distortion, depressive features, premorbid personality issues similar to eating disorders have been noted, with 67% cases having complete recovery. In this paper, we describe what is probably the first case reported from India, of a child, who presented with neuropsychiatric symptoms, and treated with electroconvulsive therapy along with medications, but, sadly had a fatal outcome.
Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India; Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India. Electronic address: sowmeey@gmail.com.
Sowmyashree Mayur
SM
Kaku
Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
John Vijay Sagar
JV
Kommu
Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
Shekhar
S
Seshadri
Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
Satish Chandra
SC
Girimaji
Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
Shoba
S
Srinath
D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D004565:Electroconvulsive Therapy / Q000379:methods*; D017809:Fatal Outcome; D001068:Feeding and Eating Disorders / Q000523:psychology; D005260:Female; D006801:Humans; D010288:Parenteral Nutrition / Q000379:methods; D012720:Severity of Illness Index; D012918:Social Alienation / Q000523:psychology; D016312:Treatment Refusal / Q000523:psychology*
D000928:Antidepressive Agents; D014150:Antipsychotic Agents
Anxiety; Depression; Eating disorders; Electroconvulsive therapy; Neuropsychiatry; Pervasive refusal syndrome