Contemporary approaches for imaging skeletal metastasis.
The skeleton is a common site of cancer metastasis. Notably high incidences of bone lesions are found for breast, prostate, and renal carcinoma. Malignant bone tumors result in significant patient morbidity. Identification of these lesions is a critical step to accurately stratify patients, guide treatment course, monitor disease progression, and evaluate response to therapy. Diagnosis of cancer in the skeleton typically relies on indirect bone-targeted radiotracer uptake at sites of active bone remodeling. In this manuscript, we discuss established and emerging tools and techniques for detection of bone lesions, quantification of skeletal tumor burden, and current clinical challenges.
Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center , New York, NY, USA ; Department of Surgery, Skåne University Hospital , Lund, Sweden.
David
D
Ulmert
Division of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Lilja
L
Solnes
Division of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, MD, USA ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Daniel Lj
DLj
Thorek