Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective, especially for the advanced forms of the disease. In the last year, short double stranded RNA molecules termed small interfering RNAs (siRNAs) and micro interfering RNAs (miRNA), emerged as interesting molecules with potential therapeutic value for HCC. The practical use of these molecules is however limited by the identification of optimal molecular targets and especially by the lack of effective and targeted HCC delivery systems. Here we focus our discussion on the most recent advances in the identification of siRNAs/miRNAs molecular targets and on the development of suitable siRNA/miRNAs delivery systems.
Rossella Farra, Mario Grassi, Department of Industrial Engineering and Information Technology, University of Trieste, 34100 Trieste, Italy.
Rossella
R
Farra
Rossella Farra, Mario Grassi, Department of Industrial Engineering and Information Technology, University of Trieste, 34100 Trieste, Italy.
Mario
M
Grassi
Rossella Farra, Mario Grassi, Department of Industrial Engineering and Information Technology, University of Trieste, 34100 Trieste, Italy.
Gabriele
G
Grassi
Rossella Farra, Mario Grassi, Department of Industrial Engineering and Information Technology, University of Trieste, 34100 Trieste, Italy.
Barbara
B
Dapas
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D015972:Gene Expression Regulation, Neoplastic; D018014:Gene Transfer Techniques; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D035683:MicroRNAs / Q000235:genetics / Q000627:therapeutic use*; D034741:RNA, Small Interfering / Q000235:genetics / Q000627:therapeutic use*; D000067492:RNAi Therapeutics
D035683:MicroRNAs; D034741:RNA, Small Interfering
Delivery; Hepatocellular carcinoma; Micro interfering RNA; Small interfering RNA; Therapeutic potential