Increasing depth penetration in biological tissue imaging using 808-nm excited Nd3+/Yb3+/Er3+-doped upconverting nanoparticles.
Ytterbium (Yb 3+ )-sensitized upconverting nanoparticles (UCNPs) are excited at 975 nm causing relatively high absorption in tissue. A new type of UCNPs with neodymium (Nd 3+ ) and Yb 3+ codoping is excitable at a 808-nm wavelength. At this wavelength, the tissue absorption is lower. Here we quantify, both experimentally and theoretically, to what extent Nd 3+ -doped UCNPs will provide an increased signal at larger depths in tissue compared to conventional 975-nm excited UCNPs.
Hugo
H
Söderlund
Monirehalsadat
M
Mousavi
Haichun
H
Liu
Stefan
S
Andersson-Engels
D000465:Algorithms; D003287:Contrast Media; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008856:Microscopy, Fluorescence / Q000379:methods*; D010316:Particle Size; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D003287:Contrast Media