[THE EFFECTS OF CHRO- NIC ADMINISTRATION OF MODERATE DOSE OF PROINFLAMMATORY CYTOKINE INTERLEUKIN-1β ON RAT INVESTIGATIVE BEHAVIOR AND SPATIAL MEMORY].
The aim of this study was to discover the effects of chronic intraperitoneal administration of proinflammatory cytokine interleukin-1β (IL-1β) on rat investigative behavior and spatial memory. Rats were injected with a moderate pyrogenic dose of IL-1β (0.5 mkg/kg) daily during 14 days (7 days before tests and 7 testing days). The behavior was examined in 23.5 hours after the previous injection of cytokine. The test battery included: "The open field" (within 3 consecutive days), "The exploration of novel objects", and "The Morris water maze". The animals treated with IL-1β differed from the control animals in an essential decrease of locomotor activity, slight increase of anxiety and suppression of exploratory behavior. The impairment of spatial memory was not revealed.
S V
SV
Kalemenev
V V
VV
Sizov
A M
AM
Ischenko
O E
OE
Zubareva
D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D053583:Interleukin-1beta / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D065852:Spatial Memory / Q000187:drug effects* / Q000502:physiology
D053583:Interleukin-1beta