Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.
The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells. In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10-independent manner. Our data show that calcitriol represses the expression of BATF, a transcription factor essential for Th9, via suppressing the expression of aryl hydrocarbon receptor, without an increase in IL-10. The data show a novel link between vitamin D and two key transcription factors involved in T cell differentiation.
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;
Mariko
M
Takami
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; Van Kampen Cardio Pulmonary Research Laboratory, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; and.
Kotaro
K
Fujimaki
Department of Surgery, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153.
Michael I
MI
Nishimura
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; Van Kampen Cardio Pulmonary Research Laboratory, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; and miwashima@luc.edu.
Makio
M
Iwashima
D001249:Asthma / Q000276:immunology; D050976:Basic-Leucine Zipper Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002117:Calcitriol / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000037:antagonists & inhibitors / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D034622:RNA Interference; D034741:RNA, Small Interfering; D018336:Receptors, Aryl Hydrocarbon / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology
C099359:BATF protein, human; D050976:Basic-Leucine Zipper Transcription Factors; C508609:IL10 protein, human; D034741:RNA, Small Interfering; D018336:Receptors, Aryl Hydrocarbon; D016753:Interleukin-10; D002117:Calcitriol