Five New Guaiane Sesquiterpenes from the Endophytic Fungus Xylaria sp. YM 311647 of Azadirachta indica.
Five new guaiane sesquiterpenes, 1-5, were isolated from the culture broth of the endophytic fungus Xylaria sp. YM 311647, isolated from Azadirachta indica A. Juss. The structures of these compounds were elucidated on the basis of spectroscopic analyses, and their inhibitory activities against five pathogenic fungi were evaluated. All guaiane sesquiterpenes showed moderate or weak antifungal activities in a broth microdilution assay.
School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Rong
R
Huang
Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P. R. China, (phone: +86-871-65032423).
Xiao-Song
XS
Xie
Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P. R. China, (phone: +86-871-65032423).
Xiao-Wei
XW
Fang
Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P. R. China, (phone: +86-871-65032423).
Kai-Xia
KX
Ma
Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P. R. China, (phone: +86-871-65032423). shwu123@126.com.
Shao-Hua
SH
Wu
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031601:Azadirachta / Q000382:microbiology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013098:Xylariales / Q000737:chemistry*
D000935:Antifungal Agents; D045789:Sesquiterpenes, Guaiane
Antifungal activity; Endophytic fungi; Guaiane sesquiterpenes; Xylaria