P wave duration and dispersion and QT interval in multiple sclerosis.
BACKGROUND
Multiple sclerosis (MS) is one of the most frequent disorders of central nervous system, resulting in autonomic disturbances. Some electrocardiographic changes have been reported in these patients that can lead to arrhythmia. In this study we compared P wave duration and dispersion and QT interval of MS patients to healthy control subjects.


METHODS
Eighty four multiple sclerosis patients and 84 healthy, age and sex-matched volunteers were included. A 12-lead electrocardiogram was undertaken in order to measure minimal and maximal P wave duration, P wave dispersion (PWD) and QT interval.


RESULTS
In patient group, mean P wave duration, maximum P wave duration and PWD were significantly longer than control group. QT interval was longer in patient group but the difference was not significant.


CONCLUSIONS
In this study, P wave duration and P wave dispersion was found to be higher in MS patients than healthy control subjects.
Department of Neurology, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
Nazanin
N
Razazian
Department of Cardiology, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
Neda
N
Hedayati
Department of Neurology, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran. Electronic address: moradiannasrin60@yahoo.com.
Nasrin
N
Moradian
Department of Neurology, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
Arash
A
Bostani
Department of Neurology, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
Daryoush
D
Afshari
Department of Cardiology, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
Nader
N
Asgari
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
Autonomic dysfunction; Cardiac arrhythmia; Multiple sclerosis; P wave dispersion (PWD); QT interval