Heavy Metal Bioaccumulation in an Atypical Primitive Neuroectodermal Tumor of the Abdominal Wall.
Heavy metals are able to interfere with the function of vital cellular components. Besides in trace heavy metals, which are essential at low concentration for humans, there are heavy metals with a well-known toxic and oncogenic potential. In this study, for the first time in literature, we report the unique adulthood case of an atypical primitive neuroectodermal tumor of the abdominal wall, diagnosed by histology and immunohistochemistry, with the molecular hybridization support. The neoplasia occurred in a patient chronically exposed to a transdermal delivery of heavy metal salts (aluminum and bismuth), whose intracellular bioaccumulation has been revealed by elemental microanalysis.
Department of Diagnostic and Clinical Medicine and of Public Health, Section of Pathology, University of Modena and Reggio Emilia , Modena (MO) , Italy .
Luca
L
Roncati
Antonietta Morena
AM
Gatti
Federico
F
Capitani
Giuseppe
G
Barbolini
Antonio
A
Maiorana
Beniamino
B
Palmieri
D034861:Abdominal Wall / Q000473:pathology*; D000982:Antipruritics / Q000009:adverse effects; D004577:Electron Probe Microanalysis; D000075322:Heavy Metal Poisoning; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000139:chemically induced* / Q000737:chemistry* / Q000235:genetics; D009824:Ointments / Q000009:adverse effects; D015514:Oncogene Proteins, Fusion / Q000378:metabolism; D011041:Poisoning / Q000150:complications*; D011537:Pruritus / Q000188:drug therapy
D000982:Antipruritics; C576197:EWSR1-FLI1 fusion protein, human; D009824:Ointments; D015514:Oncogene Proteins, Fusion
Aluminum; Ewing’s sarcoma/primitive euroectodermal tumor; bioaccumulation; bismuth; heavy metals; microanalysis; scanning electron microscope