Impact of acoustic airflow on intrasinus drug deposition: New insights into the vibrating mode and the optimal acoustic frequency to enhance the delivery of nebulized antibiotic.
OBJECTIVE
We investigated the impact of vibrating acoustic airflow, the high frequency (f≥100 Hz) and the low frequency (f≤45 Hz) sound waves, on the enhancement of intrasinus drug deposition.


METHODS
(81m)Kr-gas ventilation study was performed in a plastinated human cast with and without the addition of vibrating acoustic airflow. Similarly, intrasinus drug deposition in a nasal replica using gentamicin as a marker was studied with and without the superposition of different modes of acoustic airflow.


RESULTS
Ventilation experiments demonstrate that no sinus ventilation was observed without acoustic airflow although sinus ventilation occurred whatever the modes of acoustic airflow applied. Intrasinus drug deposition experiments showed that the high frequency acoustic airflow led to 4-fold increase in gentamicin deposition into the left maxillary sinus and to 2-fold deposition increase into the right maxillary sinus. Besides, the low frequency acoustic airflow demonstrated a significant increase of 4-fold and 2-fold in the right and left maxillary sinuses, respectively.


CONCLUSIONS
We demonstrated the benefit of different modes of vibrating acoustic airflow for maxillary sinus ventilation and intrasinus drug deposition. The degree of gentamicin deposition varies as a function of frequency of the vibrating acoustic airflow and the geometry of the ostia.
Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624-LINA, SFR FED 4166-IFRESIS, 10 rue de la Marandière-42270 Saint-Priest en Jarez, F-42023 Saint-Etienne, France. Electronic address: leclerc@emse.fr.
Lara
L
Leclerc
Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624-LINA, SFR FED 4166-IFRESIS, 10 rue de la Marandière-42270 Saint-Priest en Jarez, F-42023 Saint-Etienne, France.
Amira El
AE
Merhie
Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624-LINA, SFR FED 4166-IFRESIS, 10 rue de la Marandière-42270 Saint-Priest en Jarez, F-42023 Saint-Etienne, France.
Laurent
L
Navarro
University of Lyon, Jean Monnet University, EA 4624-LINA, SFR FED 4166-IFRESIS, F-42023 Saint-Etienne, France; University Hospital CHU, Nuclear Medicine Department, Saint-Etienne, France.
Nathalie
N
Prévôt
University of Lyon, Jean Monnet University, EA 4624-LINA, SFR FED 4166-IFRESIS, F-42023 Saint-Etienne, France; Centre Hospitalier Emile Roux, ENT Department, F-43012 Le Puy en Velay, France.
Marc
M
Durand
Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624-LINA, SFR FED 4166-IFRESIS, 10 rue de la Marandière-42270 Saint-Priest en Jarez, F-42023 Saint-Etienne, France.
Jérémie
J
Pourchez
D000162:Acoustics; D000281:Administration, Intranasal; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007727:Krypton Radioisotopes / Q000493:pharmacokinetics; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000378:metabolism*; D009330:Nebulizers and Vaporizers; D012123:Pulmonary Ventilation; D011877:Radionuclide Imaging; D013016:Sound; D014732:Vibration
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007727:Krypton Radioisotopes
(81m)Kr-gas ventilation; High frequency; Intrasinus deposition; Low frequency; Vibrating acoustic airflow