Copper(I)-Catalyzed Radical Addition of Acetophenones to Alkynes in Furan Synthesis.
A synthesis of multisubstituted furans from readily available acetophenones and electron-deficient alkynes via direct C(sp(3))-H bond functionalization under radical reaction conditions is described. The developed transformation is catalyzed by copper(I) salts using di-tert-butyl peroxide as an external oxidant. This method offers an efficient access to biologically important scaffolds from simple compounds.
Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie , Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.|Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund , Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Srimanta
S
Manna
Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie , Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.|Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund , Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Andrey P
AP
Antonchick