Pemphigoid Diseases as a Sign of Active Psoriasis: A Case Report and Brief Review.
BACKGROUND
Overlap of bullous pemphigoid (BP) with chronic psoriatic plaques (CPP) is a common condition. However, the association of BP with pustular psoriasis (PP) is uncommon. Moreover, perilesional erythema and pustular lesions on CPP are accepted as a sign of unstable psoriasis. Unstable psoriasis could be triggered by certain irritant topical treatments against psoriasis. These chemical agents could also induce a localized pattern of generalized PP. Here, we describe BP and PP collision in unstable CPP.


OBJECTIVE
By this observation we suggest that BP could be a sign of active psoriasis. Presumably, psoriasis-induced BP is an inflammation activity-dependent condition.


METHODS
This study is a case report and literature review.


RESULTS
The dramatic response of bullo-pustular lesions to short-term methotrexate (MTX) treatment suggests the rule of 'no psoriasis, no BP'. Presumably, MTX supressed the active inflammation of CPP and BP disappeared following CPP control.


CONCLUSIONS
BP can be a sign of active psoriasis in the present case.
Department of Dermatology and Venereology, Faculty of Medicine, Ege University, Izmir, Turkey.
Mehdi
M
Iskandarli
Bengu
B
Gerceker Turk
Banu
B
Yaman
Gunseli
G
Ozturk
D000368:Aged; D006801:Humans; D008297:Male; D010391:Pemphigoid, Bullous / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011565:Psoriasis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology