Resveratrol in the treatment of pancreatic cancer.
Pancreatic cancer (PCa), which is now the fourth most frequent cause of cancer-related death, has a median survival of less than 6 months and a 5-year survival rate of <6%. The hallmarks of this cancer include poor outcome, short survival duration, and resistance to therapy. The poor prognosis of PCa is related to its local recurrence, lymph node and liver metastases, and peritoneal dissemination. Recent studies have indicated that resveratrol has cancer-chemopreventive and anticancer activities. In this short review we summarize the chemopreventive and treatment effects of resveratrol in PCa, as follows: resveratrol inhibits the proliferation of pancreatic cancer cells; induces apoptosis and cell cycle arrest; inhibits metastasis and invasion of PCa cells; inhibits the proliferation and viability of PCa stem cells; enhances the chemoradiosensitization of PCa cells; and can affect diabetes mellitus in addition to PCa. On the basis of these data, resveratrol may be considered a potential anticancer agent for the treatment of PCa.
Department of Hepatobiliary Surgery.
Qinhong
Q
Xu
Department of Hepatobiliary Surgery.
Liang
L
Zong
Department of Hepatobiliary Surgery.
Xin
X
Chen
Department of Hepatobiliary Surgery.
Zhengdong
Z
Jiang
Department of Hepatobiliary Surgery.
Ligang
L
Nan
Department of Hepatobiliary Surgery.
Jiahui
J
Li
Department of Hepatobiliary Surgery.
Wanxing
W
Duan
Department of Hepatobiliary Surgery.
Jianjun
J
Lei
Department of Hepatobiliary Surgery.
Lun
L
Zhang
Department of Oncology.
Jiguang
J
Ma
Department of General Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Shaanxi, China.
Xuqi
X
Li
Department of Hepatobiliary Surgery.
Zheng
Z
Wang
Department of Hepatobiliary Surgery.
Zheng
Z
Wu
Department of Hepatobiliary Surgery.
Qingyong
Q
Ma
Department of Hepatobiliary Surgery.
Zhenhua
Z
Ma
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D059447:Cell Cycle Checkpoints; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D000077185:Resveratrol
apoptosis; cell cycle arrest; chemosensitization; epithelial-mesenchymal transition; proliferation; resveratrol