Protein degradation: Prime time for PROTACs.
Howard Hughes Medical Institute and Division of Biology and Biological Engineering, Caltech, Pasadena, California, USA.
Raymond J
RJ
Deshaies
D000818:Animals; D001665:Binding Sites; D006801:Humans; D058990:Molecular Targeted Therapy; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D011485:Protein Binding; D059748:Proteolysis; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry* / Q000378:metabolism; D057149:Ubiquitinated Proteins / Q000737:chemistry* / Q000378:metabolism; D054875:Ubiquitination / Q000187:drug effects
D054852:Small Molecule Libraries; D057149:Ubiquitinated Proteins; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex