Splicing Regulators and Their Roles in Cancer Biology and Therapy.
Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed.
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Maria Roméria
MR
da Silva
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Gabriela Alves
GA
Moreira
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Ronni Anderson
RA
Gonçalves da Silva
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Éverton
É
de Almeida Alves Barbosa
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Raoni
R
Pais Siqueira
Departamento de Química, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Róbson Ricardo
RR
Teixera
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Márcia Rogéria
MR
Almeida
Departamento de Veterinária, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Abelardo
A
Silva Júnior
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Juliana Lopes Rangel
JL
Fietto
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
Gustavo Costa
GC
Bressan
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy
D014408:Biomarkers, Tumor; D005819:Genetic Markers; D009363:Neoplasm Proteins