Serum matrix metalloproteinase-9 in colorectal cancer family-risk population screening.
Matrix metalloproteinase-9 (MMP-9) is related to tumour development and progression in colorectal cancer (CRC) and its utility as biomarker has been suggested. The aim of our study was to measure serum MMP-9 in asymptomatic first-degree relatives of CRC patients, and to analyse its diagnostic accuracy for the detection of advanced neoplasia (AN: advanced adenomas and CRC). Additionally, we compared its diagnostic capability with the most used non-invasive faecal immunochemical test (FIT). Serum MMP-9 was quantified by ELISA in 516 asymptomatic individuals that underwent a colonoscopy and a FIT. MMP-9 levels were significantly related to age and gender and therefore the concentration was corrected by these confounders. Corrected MMP-9 (cMMP-9) levels were higher in individuals with advanced adenomas (AA; p-value = 0.029) and AN (p-value = 0.056) compared to individuals with no neoplasia. Moreover, elevated cMMP-9 concentration was associated with more severe characteristics of adenomas (number of lesions, size and histology). Nevertheless, the diagnostic accuracy of cMMP-9 was considerably lower than that of FIT for identifying AA (22.64% vs. 47.17% sensitivity, 90% specificity) or AN (19.30% vs. 52.63% sensitivity, 90% specificity). According to our results, serum MMP-9 cannot be considered of utility for the diagnosis of AN in CRC family-risk population screening.
Department of Biochemistry, Genetics and Immunology, Universidade de Vigo. Vigo, Spain.
Olalla
O
Otero-Estévez
Department of Biochemistry, Genetics and Immunology, Universidade de Vigo. Vigo, Spain.
Loretta
L
De Chiara
SiDOR Research Group &Centro de Investigaciones Biomédicas (CINBIO), Universidade de Vigo. Vigo, Spain.
Mar
M
Rodríguez-Girondo
Department of Biochemistry, Genetics and Immunology, Universidade de Vigo. Vigo, Spain.
Francisco Javier
FJ
Rodríguez-Berrocal
Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense. Ourense, Spain.
Joaquín
J
Cubiella
Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense. Ourense, Spain.
Inés
I
Castro
Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo. Vigo, Spain.
Vicent
V
Hernández
Department of Biochemistry, Genetics and Immunology, Universidade de Vigo. Vigo, Spain.
Vicenta Soledad
VS
Martínez-Zorzano
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000201:enzymology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors
D014408:Biomarkers, Tumor; D020780:Matrix Metalloproteinase 9