Role of motor end plate-targeted Botulinum toxin type A injections in children with cerebral palsyitle.
Botulinum toxin type A (BTX) injections are frequently used in children with cerebral palsy (CP) to control spasticity. Injection variables still lead to variable outcomes of this treatment. Using instrumented spasticity assessment and muscle volume assessment the most effective location of the injection was demonstrated for gracilis and psoas muscles in children with CP. It was found that this treatment is most effective when injected in the motor endplate zones of the selected muscles. This review article presents all available research on the role of motor endplate-targeting of BTX injections in children with CP.
Anja
A
Van Campenhout
Lynn
L
Bar-On
Kaat
K
Desloovere
Guy
G
Molenaers
D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D002547:Cerebral Palsy / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D006801:Humans; D007273:Injections, Intramuscular; D009045:Motor Endplate / Q000187:drug effects* / Q000503:physiopathology; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D009465:Neuromuscular Agents / Q000008:administration & dosage; D016658:Psoas Muscles
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A