Photorefractive keratectomy in 22 adult eyes with infantile nystagmus syndrome.
OBJECTIVE
To analyze visual and refractive outcomes of photorefractive keratectomy (PRK) in adult patients with infantile nystagmus syndrome.


METHODS
Ophthalmology Unit, Department of Experimental Diagnostic and Specialty Medicine, Saint Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.


METHODS
Retrospective case series.


METHODS
Photorefractive keratectomy was performed in both eyes of patients with infantile nystagmus syndrome under topical anesthesia using an eye-tracking excimer laser. Patient satisfaction was tested using a questionnaire. The main outcomes were a decrease in refractive error, an improvement in postoperative corrected distance visual acuity (CDVA), and an uncorrected distance visual acuity (UDVA) equal to or better than the preoperative UDVA.


RESULTS
Twenty-two eyes of 11 patients with infantile nystagmus syndrome were evaluated. The mean patient age was 30.82 years (range 22 to 42 years). All eyes had simple, compound, or mixed astigmatism (mean -3.40 D; range -0.75 to -6.00 diopters [D]). The mean postoperative astigmatism (-0.70 D ± 0.81 [SD]) and spherical equivalent (-0.420 ± 0.652 D) were statistically significantly better than the preoperative values (-3.40 ± 1.31 D and -3.426 ± 3.343 D, respectively (P < .0001 and P = .0002, respectively). The mean monocular postoperative CDVA (0.24 ± 0.19 logMAR) and UDVA (0.25 ± 0.18 logMAR) were better than the mean preoperative CDVA (0.32 ± 0.28 logMAR) (P = .0045 and P = .0338, respectively). The mean binocular postoperative UDVA was better than the mean preoperative CDVA (0.15 ± 0.14 logMAR versus 0.23 ± 0.23 logMAR) (P = .05). No patient required repeat surgery.


CONCLUSIONS
Nystagmus patients are eligible for PRK. The results were promising; gaining a few Snellen lines in visual acuity can be very important to these patients for their daily life.


BACKGROUND
No author has a financial or proprietary interest in any material or method mentioned.
From the Department of Specialist, Diagnostics and Experimental Medicine, Ophthalmology Unit, University of Bologna, Bologna, Italy.
Michela
M
Fresina
From the Department of Specialist, Diagnostics and Experimental Medicine, Ophthalmology Unit, University of Bologna, Bologna, Italy. Electronic address: giuseppe.giannaccare@gmail.com.
Giuseppe
G
Giannaccare
From the Department of Specialist, Diagnostics and Experimental Medicine, Ophthalmology Unit, University of Bologna, Bologna, Italy.
Corrado
C
Gizzi
From the Department of Specialist, Diagnostics and Experimental Medicine, Ophthalmology Unit, University of Bologna, Bologna, Italy.
Piera
P
Versura
From the Department of Specialist, Diagnostics and Experimental Medicine, Ophthalmology Unit, University of Bologna, Bologna, Italy.
Emilio C
EC
Campos
D000328:Adult; D001251:Astigmatism / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D020417:Nystagmus, Congenital / Q000503:physiopathology / Q000601:surgery*; D017060:Patient Satisfaction; D018903:Photorefractive Keratectomy / Q000379:methods*; D012029:Refraction, Ocular / Q000502:physiology*; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D015348:Vision, Binocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult