Copper-Catalyzed Diazo Cross-/Homo-Coupling toward Tetrasubstituted Olefins and Applications on the Synthesis of Maleimide Derivatives.
A challenging selective intermolecular cross-coupling and homocoupling of aryl-aryl or aryl-alkyl diazo compounds has been accomplished via a copper system, which afforded tetrasubstituted olefins in moderate to high yields with good to excellent Z-selectivity. This novel methodology enables rapid synthesis of tetrasubstituted olefins, which would find broad application in accessing maleimide libraries of nature products and bioactive small molecules.
School of Pharmaceutical Engineering & Life Science, and Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University , Changzhou 213164, P. R. China.
Chenghao
C
Zhu
School of Pharmaceutical Engineering & Life Science, and Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University , Changzhou 213164, P. R. China.
Guangyang
G
Xu
School of Pharmaceutical Engineering & Life Science, and Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University , Changzhou 213164, P. R. China.
Dong
D
Ding
School of Pharmaceutical Engineering & Life Science, and Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University , Changzhou 213164, P. R. China.
Lin
L
Qiu
School of Pharmaceutical Engineering & Life Science, and Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University , Changzhou 213164, P. R. China.
Jiangtao
J
Sun
D000475:Alkenes / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000475:Alkenes; D001391:Azo Compounds; D001688:Biological Products; D006847:Hydrocarbons, Iodinated; D008301:Maleimides; D003300:Copper