Simultaneous occurrence of focal nodular hyperplasia and HNF1A-inactivated hepatocellular adenoma: a collision tumor simulating a composite FNH-HCA.
Mixed focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) within a single tumor mass is rarely reported, and most of these cases are examples of tumors with features intermediate between FNH and HCA. Although a few reported cases are probably examples of true mixed tumors, none was evaluated immunohistochemically or confirmed by molecular analysis. We report a mixed FNH and HCA arising in a woman with several HNF1A-inactivated adenomas. Our case is the first case of mixed FNH and HNF1A-inactivated HCA documented by immunohistochemistry.
*James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA †Inserm U1053, Université de Bordeaux ‡Pathology Department, Pellegrin Hospital, CHU Bordeaux, Bordeaux, France.
Angela
A
Shih
Gregory Y
GY
Lauwers
Charles
C
Balabaud
Paulette
P
Bioulac-Sage
Joseph
J
Misdraji
D018248:Adenoma, Liver Cell / Q000737:chemistry / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D001706:Biopsy; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000473:pathology* / Q000601:surgery; D020868:Gene Silencing; D020022:Genetic Predisposition to Disease; D006498:Hepatectomy; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D010641:Phenotype; D011237:Predictive Value of Tests
D014408:Biomarkers, Tumor; C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha