Biomimetic synthesis of Tramadol.
Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product-precursor relationship has been probed by (13)C position-specific isotope analysis. By further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved using mild conditions that mimic in vivo catalysis.
Univ. Grenoble-Alpes, DPM UMR 5063, F-38041 Grenoble, France. Ahcene.Boumendjel@ujf-grenoble.fr.
Florine
F
Lecerf-Schmidt
Romain
R
Haudecoeur
Basile
B
Peres
Marcos Marçal
MM
Ferreira Queiroz
Laurence
L
Marcourt
Soura
S
Challal
Emerson
E
Ferreira Queiroz
Germain
G
Sotoing Taiwe
Thierry
T
Lomberget
Marc
M
Le Borgne
Jean-Luc
JL
Wolfender
Michel
M
De Waard
Richard J
RJ
Robins
Ahcène
A
Boumendjel
D000701:Analgesics, Opioid / Q000138:chemical synthesis*; D032701:Biomimetics; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D014147:Tramadol / Q000138:chemical synthesis*
D000701:Analgesics, Opioid; D014147:Tramadol