THE ACTION OF AVOCADO OIL ON THE LIPIDOGRAM OF WISTAR RATS SUBMITTED TO PROLONGED ANDROGENIC STIMULUM.
BACKGROUND
the abuse of steroid hormones administered in chronic form may cause alterations in the lypidic profile, conveying na increase in the levels of LDL, and reduction in the levels of HDL. In average, 53.44% of the lypidic composition of the avocado core is composed of oleic acid (which is a phytosterol) and the study of the hypolipemiating effect of these substances has been performed aiming at the prevention and control of dislypidemias.


OBJECTIVE
to assess the potential hypolipemiant power of the avocado oil on the lypidogram of adult male Wistar rats submitted to prolonged androgenic hiperestimulation.


METHODS
twenty eight Wistar rats were divided in 4 groups of 7 animals: the control group (CG); Avocado Oil Group (AOG) fed with a staple based on Avocado Oil; Induced Grupo (IG); and the Induced Grupo fed with a staple based on Avocado Oil (AOIG). The inducing was performed through surgery to subcutaneously implant sillicon pellets suffed with 1 ml of testosterone propionate which were replaced at every 4 weeks.


RESULTS
VLDL (AOIG: 28.14 ± 4.45; IG:36.83 ± 5.56 mg/ml); Triglicerides (AOIG: 140.07 ± 22.66; IG: 187.2 ± 27 mg/ml); HDL (AOIG: 40, 67 ± 1.2; GI: 35.09 ± 0.8; AOG: 32.31 ± 2.61 e CG: 32.36 ± 4.93 mg/ml) Testosterone (AOIG:1.42 ± 0.46; GI: 2.14 ± 0.88; AOG: 2.97 ± 1.34 e CG:1.86 ± 0.79 ng/ml).


CONCLUSIONS
avocado Oil exerted a direct regulating effect on the lypidic profile, acting efficiently on animals submmited to androgenic stimulation through a prolonged period.
Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University.. chagas.m@gmail.com.
Renato
R
de Souza Abboud
Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University.. chagas.m@gmail.com.
Vivian
V
Alves Pereira
Laboratory of Experimental Nutrition. Departament of Nutrition and Dietetics. Fluminense Federal University. Rio de Janeiro, Brazil.. chagas.m@gmail.com.
Carlos Alberto
CA
Soares da Costa
Laboratory of Experimental Nutrition. Departament of Nutrition and Dietetics. Fluminense Federal University. Rio de Janeiro, Brazil.. chagas.m@gmail.com.
Gilson
G
Teles Boaventura
Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University.. chagas.m@gmail.com.
Mauricio
M
Alves Chagas
D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D027421:Persea / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D000728:Androgens; D008055:Lipids; D010936:Plant Extracts; D010938:Plant Oils