Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex.
Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selective dopamine D1 receptor agonist SKF81297 on acquisition and retrieval in the novel object recognition task in male Wistar rats. SKF81297 (0.4 and 0.8 mg/kg s.c.) given 15 min before the sampling phase impaired novel object recognition evaluated 10 min or 24 h later. The same treatments also reduced novel object recognition memory tested 24 h after the sampling phase and when given 15 min before the choice session. These data indicate that D1 receptor stimulation modulates both the encoding and retrieval of object recognition memory. Microinfusion of SKF81297 (0.025 or 0.05 μg/side) into the prelimbic sub-region of the medial prefrontal cortex (mPFC) in this case 10 min before the sampling phase also impaired novel object recognition memory, suggesting that the mPFC is one important site mediating the effects of D1 receptor stimulation on visual recognition memory.
School of Psychology, University of Nottingham, Nottingham, UK. Electronic address: marie.pezze@nottingham.ac.uk.
Marie A
MA
Pezze
School of Psychology, University of Nottingham, Nottingham, UK.
Hayley J
HJ
Marshall
School of Life Sciences, University of Nottingham, Nottingham, UK.
Kevin C F
KC
Fone
School of Psychology, University of Nottingham, Nottingham, UK.
Helen J
HJ
Cassaday
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism*; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000819:agonists* / Q000378:metabolism*; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D001552:Benzazepines; D018697:Nootropic Agents; D017447:Receptors, Dopamine D1; C067113:SK&F 81297
D(1) receptors; Medial prefrontal cortex; Novel object recognition; Rat; SKF81297