Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters.
The purpose of this work was to develop a family of cross-linked poly(xylitol adipate salicylate)s with a wide range of tunable release properties for delivering pharmacologically active salicylic acid. The synthesis parameters and release conditions were varied to modulate polyester properties and to understand the mechanism of release. Varying release rates were obtained upon longer curing (35% in the noncured polymer to 10% in the cured polymer in 7 days). Differential salicylic acid loading led to the synthesis of polymers with variable cross-linking and the release could be tuned (100% release for the lowest loading to 30% in the highest loading). Controlled release was monitored by changing various factors, and the release profiles were dependent on the stoichiometric composition, pH, curing time, and presence of enzyme. The polymer released a combination of salicylic acid and disalicylic acid, and the released products were found to be nontoxic. Minimal hemolysis and platelet activation indicated good blood compatibility. These polymers qualify as "bioactive" and "resorbable" and can, therefore, find applications as immunomodulatory resorbable biomaterials with tunable release properties.
Centre for Biosystems Science and Engineering, ‡Department of Materials Engineering, and §Department of Chemical Engineering, Indian Institute of Science , Bangalore 560012, India.
Queeny
Q
Dasgupta
Centre for Biosystems Science and Engineering, ‡Department of Materials Engineering, and §Department of Chemical Engineering, Indian Institute of Science , Bangalore 560012, India.
Kaushik
K
Chatterjee
Centre for Biosystems Science and Engineering, ‡Department of Materials Engineering, and §Department of Chemical Engineering, Indian Institute of Science , Bangalore 560012, India.
Giridhar
G
Madras
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007641:Keratolytic Agents / Q000494:pharmacology*; D051379:Mice; D041681:NIH 3T3 Cells; D010973:Platelet Adhesiveness / Q000187:drug effects; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D020156:Salicylic Acid / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D007641:Keratolytic Agents; D011091:Polyesters; D011108:Polymers; D020156:Salicylic Acid
biodegradable polymers; controlled release; polyester; salicylic acid