Rhabdomyolysis Caused by Candida parapsilosis in a Patient with Acute Myeloid Leukemia after Bone Marrow Transplantation.
Rhabdomyolysis is characterized by a marked elevation of the creatine kinase (CK) levels and myoglobinuria, thus leading to renal dysfunction. Various viruses or bacteria can be etiologic agents, but mycosis has only rarely been reported to be a cause of rhabdomyolysis. In this report, we describe an adolescent male with acute myeloid leukemia who underwent allogeneic bone marrow transplantation and thereafter developed rhabdomyolysis and Candida parapsilosis fungemia almost at the same time. Following treatment for C. parapsilosis, the transaminase and CK levels both satisfactorily decreased. This case illustrates that C. parapsilosis infection may be a causative agent of rhabdomyolysis in immunocompromised patients.
Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Japan.
Seiji
S
Kakiuchi
Kimikazu
K
Yakushijin
Katsuya
K
Yamamoto
Hideo
H
Tomioka
Yumiko
Y
Inui
Atsuo
A
Okamura
Shinichiro
S
Kawamoto
Yosuke
Y
Minami
Tohru
T
Murayama
Mitsuhiro
M
Ito
Hiroshi
H
Matsuoka
Hironobu
H
Minami
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D016469:Fungemia / Q000382:microbiology*; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000150:complications / Q000628:therapy*; D008297:Male; D008826:Microbial Sensitivity Tests; D012074:Remission Induction; D012206:Rhabdomyolysis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology
D000935:Antifungal Agents