Intraoperative MRI for optimizing electrode placement for deep brain stimulation of the subthalamic nucleus in Parkinson disease.
OBJECT The degree of clinical improvement achieved by deep brain stimulation (DBS) is largely dependent on the accuracy of lead placement. This study reports on the evaluation of intraoperative MRI (iMRI) for adjusting deviated electrodes to the accurate anatomical position during DBS surgery and acute intracranial changes. METHODS Two hundred and six DBS electrodes were implanted in the subthalamic nucleus (STN) in 110 patients with Parkinson disease. All patients underwent iMRI after implantation to define the accuracy of lead placement. Fifty-six DBS electrode positions in 35 patients deviated from the center of the STN, according to the result of the initial postplacement iMRI scans. Thus, we adjusted the electrode positions for placement in the center of the STN and verified this by means of second or third iMRI scans. Recording was performed in adjusted parameters in the x-, y-, and z-axes. RESULTS Fifty-six (27%) of 206 DBS electrodes were adjusted as guided by iMRI. Electrode position was adjusted on the basis of iMRI 62 times. The sum of target coordinate adjustment was -0.5 mm in the x-axis, -4 mm in the y-axis, and 15.5 mm in the z-axis; the total of distance adjustment was 74.5 mm in the x-axis, 88 mm in the y-axis, and 42.5 mm in the z-axis. After adjustment with the help of iMRI, all electrodes were located in the center of the STN. Intraoperative MRI revealed 2 intraparenchymal hemorrhages in 2 patients, brain shift in all patients, and leads penetrating the lateral ventricle in 3 patients. CONCLUSIONS The iMRI technique can guide surgeons as they adjust deviated electrodes to improve the accuracy of implanting the electrodes into the correct anatomical position. The iMRI technique can also immediately demonstrate acute changes such as hemorrhage and brain shift during DBS surgery.
Department of Neurosurgery, PLA General Hospital, PLA Postgraduate Medical School, Beijing; and.
Zhiqiang
Z
Cui
Department of Neurosurgery, PLA General Hospital, PLA Postgraduate Medical School, Beijing; and.
Longsheng
L
Pan
Department of Neurology, Hebei Province Luan County People's Hospital, Luan County, Hebei Province, China.
Huifang
H
Song
Department of Neurosurgery, PLA General Hospital, PLA Postgraduate Medical School, Beijing; and.
Xin
X
Xu
Department of Neurosurgery, PLA General Hospital, PLA Postgraduate Medical School, Beijing; and.
Bainan
B
Xu
Department of Neurosurgery, PLA General Hospital, PLA Postgraduate Medical School, Beijing; and.
Xinguang
X
Yu
Department of Neurosurgery, PLA General Hospital, PLA Postgraduate Medical School, Beijing; and.
Zhipei
Z
Ling
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D059906:Neuroimaging / Q000379:methods*; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods*; D010300:Parkinson Disease / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D019106:Postoperative Hemorrhage / Q000453:epidemiology; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000033:anatomy & histology / Q000601:surgery*
AC = anterior commissure; DBS = deep brain stimulation; MER = microelectrode recording; MP-RAGE = magnetization-prepared rapid gradient echo; PC = posterior commissure; Parkinson’s disease; STN = subthalamic nucleus; deep brain stimulation; functional neurosurgery; iMRI = intraoperative MRI; intraoperative magnetic resonance imaging; subthalamic nucleus