Chromenone-conjugated magnetic iron oxide nanoparticles. Toward conveyable DNA binders.
Magnetic nanoparticles can transport drug and possibly target cancer. DNA-binding of ligands loaded in dextran coated magnetic nanoparticles, could aid their better target-specific binding. In this work, we report the loading of chromenones onto aminoethylamino-modified dextran coated iron oxide nanoparticles, their loading efficiency, and openness for binding to DNA. The magnetic behavior, the size, and the morphology of the nanoparticles are analyzed. The crystallite size of the magnetic nanoparticles is around 40 nm. The chromenones are present on the surface of the dextran shell, as revealed by their cyclodextrin-binding characteristics, which is a new approach in comprehending the accessibility of the surface-bound molecules by macromolecules. The mode of binding of the chromenones to DNA is not altered on surface loading on dextran shell, although the binding strength is generally diminished, compared to the strength of binding of the free chromenones to DNA.
Department of Chemistry, Karunya University, Coimbatore - 641114 Tamil Nadu, India.
Sameena
S
Yousuf
Department of Chemistry, Karunya University, Coimbatore - 641114 Tamil Nadu, India; Department of Nanosciences and Technology, Karunya University, Coimbatore - 641114, Tamilnadu, India. Electronic address: drisraelenoch@gmail.com.
Israel V M V
IVMV
Enoch
Department of Chemistry, Karunya University, Coimbatore - 641114 Tamil Nadu, India.
Mosae Selvalumar
MS
Paulraj
Department of Bioinformatics, Karunya University, Coimbatore - 641114, Tamilnadu, India.
Premnath
P
Dhanaraj
D017608:Chromium Compounds / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D047392:beta-Cyclodextrins / Q000737:chemistry
D017608:Chromium Compounds; D003911:Dextrans; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D047392:beta-Cyclodextrins; C000499:ferric oxide; D004247:DNA; C427203:calf thymus DNA
Chromenone; DNA; Dextran; Iron oxide; Magnetic nanoparticles; β-Cyclodextrin