Synthesis and characterisation of a pH-sensitive magnetic nanocomposite for controlled delivery of doxorubicin.
We prepared a magnetic chitosan-cis-aconitic anhydride-doxorubicin nanocomposite, denoted by MCS-CAA-DOX. Chitosan (CS) was linked to magnetic nanoparticles (Fe3O4) to decrease cytotoxicity of the composite and provided a large number of reactive sites for coupling of drug molecules. DOX was attached to the magnetic chitosan (MCS) via a pH-sensitive linker, cis-aconitic anhydride, which hydrolyses in the acidic lysosomal environment to allow pH-responsive release of DOX. The prepared nanocomposites were within 15 nm and had good superparamagnetic properties. The loading rate of DOX was up to 83%. It was found that nearly 88% DOX was released within 60 h at pH 5.0, compared with only 29% at pH 7.4.
a National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology , Nanjing , China.
Shan Shan
SS
Xu
Juan
J
Wu
Wei
W
Jiang
D002470:Cell Survival; D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
D004337:Drug Carriers; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D004317:Doxorubicin; D048271:Chitosan
Chitosan; drug delivery; magnetic nanocomposites; pH-sensitive