Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions.
Hydrophilic coordinating chiral ionic liquids with an amino alcohol substructure were developed and efficiently applied to the asymmetric reduction of ketones. Their careful design and adaptability to the desired reaction conditions allow for these chiral ionic liquids to be used as the sole source of chirality in a ruthenium-catalyzed transfer hydrogenation reaction of aromatic ketones. When used in this reaction system, these chiral ionic liquids afforded excellent yields and high enantioselectivities.
Institute of Applied Synthetic Chemistry, Vienna University of Technology Getreidemarkt 9/163, 1060 Vienna, Austria E-mail: katharina.bica@tuwien.ac.at http://www.ias.tuwien.ac.at/home/
Maria
M
Vasiloiu
Institute of Applied Synthetic Chemistry, Vienna University of Technology Getreidemarkt 9/163, 1060 Vienna, Austria E-mail: katharina.bica@tuwien.ac.at http://www.ias.tuwien.ac.at/home/
Peter
P
Gaertner
Laboratory for Bioinspired Materials, Department of NanoBiotechnology, BOKU - University of Natural Resources and Life Sciences Vienna Muthgasse 11, 1190 Vienna, Austria.
Ronald
R
Zirbs
Institute of Applied Synthetic Chemistry, Vienna University of Technology Getreidemarkt 9/163, 1060 Vienna, Austria E-mail: katharina.bica@tuwien.ac.at http://www.ias.tuwien.ac.at/home/
Katharina
K
Bica
Asymmetric catalysis; Hydrogenation; Ionic liquids; Ketones; Ruthenium; Self-assembly