Can adaptive treatment improve outcomes in family-based therapy for adolescents with anorexia nervosa? Feasibility and treatment effects of a multi-site treatment study.
OBJECTIVE
Adolescents with Anorexia Nervosa (AN), treated with family-based treatment (FBT) who fail to gain 2.3 kg by the fourth week of treatment have a 40-50% lower chance of recovery than those who do. Because of the high risk of developing enduring AN, improving outcomes in this group of poor responders is essential. This study examines the feasibility and effects of a novel adaptive treatment (i.e., Intensive Parental Coaching-IPC) aimed at enhancing parental self-efficacy related to re-feeding skills in poor early responders to FBT.


METHODS
45 adolescents (12-18 years of age) meeting DSM TR IV criteria for AN were randomized in an unbalanced design (10 to standard FBT; 35 to the adaptive arm). Attrition, suitability, expectancy rates, weight change, and psychopathology were compared between groups.


RESULTS
There were no differences in rates of attrition, suitability, expectancy ratings, or most clinical outcomes between randomized groups. However, the group of poor early responders that received IPC achieved full weight restoration (>95% of expected mean BMI) by EOT at similar rates as those who had responded early.


CONCLUSIONS
The results of this study suggest that it is feasible to use an adaptive design to study the treatment effect of IPC for those who do not gain adequate weight by session 4 of FBT. The results also suggest that using IPC for poor early responders significantly improves weight recovery rates to levels comparable to those who respond early. A sufficiently powered study is needed to confirm these promising findings.
Department of Psychiatry and Behavioral Sciences, University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA. Electronic address: jimlock@stanford.edu.
James
J
Lock
Department of Psychiatry, UCSF, USA.
Daniel
D
Le Grange
Department of Psychiatry and Behavioral Sciences, University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA.
W Stewart
WS
Agras
Department of Psychiatry and Behavioral Sciences, University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA.
Kathleen Kara
KK
Fitzpatrick
Department of Psychiatry and Behavioral Sciences, University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA.
Booil
B
Jo
Department of Psychiatry, UCSF, USA.
Erin
E
Accurso
Department of Psychiatry and Behavioral Sciences, University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA.
Sarah
S
Forsberg
Department of Psychiatry& Behavioral Neuroscience, The University of Chicago, USA.
Kristen
K
Anderson
Department of Psychiatry and Behavioral Sciences, University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA.
Kate
K
Arnow
Department of Psychiatry& Behavioral Neuroscience, The University of Chicago, USA.
Maya
M
Stainer
D000293:Adolescent; D000856:Anorexia Nervosa / Q000628:therapy*; D001835:Body Weight; D002648:Child; D005196:Family Therapy / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents; D016896:Treatment Outcome; D015430:Weight Gain
Adolescents; Anorexia nervosa; Family therapy