Bivalirudin: An expensive heparin?
Bleeding rates with unfractionated heparin (UH) without concomitant use of glycoprotein IIb/IIIa inhibitors as compared to bivalirudin are similar. Ischemic event rates during the index hospitalization are similar in the heparin and bivalirudin subgroups. Low does heparin (60-70 units/kg) with a target ACT of 200-250 sec may obviate the historical improved safety of bivalirudin demonstrated in certain clinical trials.
Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon.
Saurabh
S
Gupta
Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon.
Joaquin E
JE
Cigarroa
D000925:Anticoagulants / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000627:therapeutic use*; D062645:Percutaneous Coronary Intervention
D000925:Anticoagulants; D000991:Antithrombins; D010446:Peptide Fragments; D006493:Heparin