Laser processing of polymer constructs from poly(3-hydroxybutyrate).
CO2 laser radiation was used to process poly(3-hydroxybutyrate) constructs - films and 3D pressed plates. Laser processing increased the biocompatibility of unperforated films treated with moderate uniform radiation, as estimated by the number and degree of adhesion of NIH 3T3 mouse fibroblast cells. The biocompatibility of perforated films modified in the pulsed mode did not change significantly. At the same time, pulsed laser processing of the 3D plates produced perforated scaffolds with improved mechanical properties and high biocompatibility with bone marrow-derived multipotent, mesenchymal stem cells, which show great promise for bone regeneration.
a Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , Akademgorodok, Krasnoyarsk 660036 , Russia.|b School of Fundamental Biology and Biotechnology, Siberian Federal University , 79 Svobodnyi Avenue, Krasnoyarsk 660041 , Russia.
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Volova
c School of Engineering Physics and Radio Electronics, Siberian Federal University , 79 Svobodnyi Avenue, Krasnoyarsk 660041 , Russia.
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Tarasevich
d Special Design and Technological Bureau 'Nauka' Krasnoyarsk Scientific Centre of Siberian Branch Russian Academy of Sciences , 53 Mir Avenue, Krasnoyarsk 660049 , Russia.
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Golubev
a Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , Akademgorodok, Krasnoyarsk 660036 , Russia.|b School of Fundamental Biology and Biotechnology, Siberian Federal University , 79 Svobodnyi Avenue, Krasnoyarsk 660041 , Russia.
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Boyandin
a Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , Akademgorodok, Krasnoyarsk 660036 , Russia.|b School of Fundamental Biology and Biotechnology, Siberian Federal University , 79 Svobodnyi Avenue, Krasnoyarsk 660041 , Russia.
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Shumilova
a Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , Akademgorodok, Krasnoyarsk 660036 , Russia.|b School of Fundamental Biology and Biotechnology, Siberian Federal University , 79 Svobodnyi Avenue, Krasnoyarsk 660041 , Russia.
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Nikolaeva
a Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , Akademgorodok, Krasnoyarsk 660036 , Russia.|b School of Fundamental Biology and Biotechnology, Siberian Federal University , 79 Svobodnyi Avenue, Krasnoyarsk 660041 , Russia.
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Shishatskaya
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000648:ultrastructure; D002448:Cell Adhesion; D002470:Cell Survival; D002478:Cells, Cultured; D020118:Cupriavidus necator / Q000378:metabolism; D055119:Elastic Modulus; D006801:Humans; D006885:Hydroxybutyrates / Q000737:chemistry* / Q000378:metabolism; D054020:Lasers, Gas; D008567:Membranes, Artificial; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000648:ultrastructure; D051379:Mice; D041681:NIH 3T3 Cells; D011091:Polyesters / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D016062:Porosity; D017208:Rats, Wistar; D013499:Surface Properties; D013718:Tensile Strength; D054457:Tissue Scaffolds / Q000737:chemistry*; D000094122:Polyhydroxybutyrates
D006885:Hydroxybutyrates; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates
biocompatibility; biopolymers; laser processing; poly(3-hydroxybutyrate); polymer materials