[Relevant Parameters of Optic Nerve Analysis from Spectral Domain OCT for Glaucoma Diagnostics].
BACKGROUND
In early diagnosis and follow-up of patients with glaucoma anatomic-diagnostic examinations have become more important in addition to static perimetry. Patients with open angle glaucoma suffer a slow visual field loss due to the loss of ganglion cells, which these examinations could detect earlier than perimetry can.


METHODS
Parameters of the optical coherence tomography (OCT) were analysed in 89 patients (175 eyes) with advanced open angle glaucoma. In a prospective study, the functional findings from static perimetry (HFA-II, 24-2-programme) and the anatomic parameters of optic nerve analysis with SD-OCT (Cirrus-OCT) were evaluated.


RESULTS
The results showed a mean deviation (MD) in perimetry of - 8.31 ± 9.76 dB and in the analysis of the optic nerve head of 71.93 ± 15.86 µm retinal nerve fibre layer (RNFL) as well as 85.54 ± 28.2 µm RNFL for the inferior quadrant, 0.95 ± 0.46 mm(2) for the rim area and 0.69 ± 0.18 for the vertical CD ratio. There was a significant correlation (p < 0.05) between MD und RNFL (r = 0.603), as well as RNFL of the inferior quadrant (r = 0.620), rim area (r = 0.552) and average CD ratio (r = - 0.551). The best correlation for the optical nerve head analysis was found between MD and vertical CD ratio (r = - 0.568).


CONCLUSIONS
There was a good correlation between functional and anatomic parameters in perimetry and OCT. In particular, the mean and inferior retinal nerve fibre layer thickness, the rim area, and the vertical CD ratio revealed to be significant parameters in glaucomatous eyes.
Augenklinik Berlin-Marzahn.
A J
AJ
Berthold
Klinik für Augenheilkunde, Klinikum Frankfurt (Oder).
A M L
AM
Hoang
Klinik für Augenheilkunde, Klinikum Frankfurt (Oder).
A
A
Just
Augenklinik Berlin-Marzahn.
C
C
Wirbelauer
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005902:Glaucoma, Open-Angle / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*; D009900:Optic Nerve / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult