Ten Years of Abstinence in Former Opiate Addicts: Medication-Free Non-Patients Compared to Methadone Maintenance Patients.
Fifty-five former opioid addicts who have been methadone maintained patients for 10 or more years and whose urine has tested negative for drugs for 2 or more years were compared to 99 former opioid addicts who have been medication-free for 10 or more years. Groups were comparable in age and education, but the medication-free subjects were younger when having started opioids with more severe addiction scores. Methadone maintained patients presented with a higher proportion of psychiatric comorbidity and chronic pain. Their scores of perceived sleep quality and cognitive state were poorer than the medication-free individuals. Possible explanations of the differences are discussed in this article.
a Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse, Treatment, and Research, Tel-Aviv Sourasky Medical Center , Tel Aviv , Israel.|b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
Einat
E
Peles
a Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse, Treatment, and Research, Tel-Aviv Sourasky Medical Center , Tel Aviv , Israel.
Anat
A
Sason
b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.|c Department of Psychiatry , Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.
Oren
O
Tene
a Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse, Treatment, and Research, Tel-Aviv Sourasky Medical Center , Tel Aviv , Israel.|b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.|c Department of Psychiatry , Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.
Yoav
Y
Domany
a Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse, Treatment, and Research, Tel-Aviv Sourasky Medical Center , Tel Aviv , Israel.|b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.|c Department of Psychiatry , Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.
Shaul
S
Schreiber
a Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse, Treatment, and Research, Tel-Aviv Sourasky Medical Center , Tel Aviv , Israel.
Miriam
M
Adelson
D000328:Adult; D000701:Analgesics, Opioid / Q000652:urine; D016739:Behavior, Addictive / Q000453:epidemiology / Q000534:rehabilitation; D059350:Chronic Pain / Q000453:epidemiology; D003071:Cognition / Q000187:drug effects; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use* / Q000652:urine; D008875:Middle Aged; D058850:Opiate Substitution Treatment / Q000706:statistics & numerical data*; D009293:Opioid-Related Disorders / Q000453:epidemiology / Q000534:rehabilitation*; D012890:Sleep / Q000187:drug effects; D013695:Temperance / Q000706:statistics & numerical data*
D000701:Analgesics, Opioid; D008691:Methadone
Prolonged abstinence; chronic pain; cognitive; methadone maintenance treatment; sleep