A population-based study on the associations between chronic periodontitis and the risk of cancer.
BACKGROUND
To date, the associations between chronic periodontitis (CP) and cancer lack large-scale population-based epidemiological evidence. This study aimed to investigate the subsequent risk for cancers among subjects with CP.


METHODS
This study cohort included 40,140 subjects with CP and 40,140 subjects who were matched for a comparison cohort. We individually tracked each patient for a 5-year period following their index date to identify those who had received a diagnosis of cancer.


RESULTS
The incidence rate of cancer during the 5-year follow-up period was 14.80 (95 % CI 14.28-15.34) per 1,000 person-years in subjects with CP. Cox proportional hazards regression revealed that the hazard ratio of cancer during the 5-year follow-up period for subjects with CP was 1.23 (95 % CI 1.20-1.27) compared to that of the comparison cohort.


CONCLUSIONS
We observed an increased risk for the subsequent development of a number of cancers among subjects with CP.
Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan.
Shiu-Dong
SD
Chung
Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan.
Ming-Chieh
MC
Tsai
School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
Chung-Chien
CC
Huang
Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan. kaoliting@gmail.com.
Li-Ting
LT
Kao
Department of Thoracic Surgery, Mackay Memorial Hospital, Taipei, Taiwan.|Mackay Medicine Nursing, and Management College, Taipei, Taiwan.
Chao-Hung
CH
Chen
D000328:Adult; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000150:complications*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
Cancer; Chronic periodontitis; Epidemiology