Mucosal CD30-Positive T-Cell Lymphoproliferative Disorder Arising in the Oral Cavity Following Dental Implants: Report of the First Case.
Mucosal CD30-positive T-cell lymphoproliferative disorder (CD30+ T-cell LPD) is a novel entity with unique clinicopathological features and an indolent behavior. Here we report the first case of mucosal CD30+ T-cell LPD arising in the oral cavity following dental implant. A 70-year-old woman presented with swelling and redness of the oral mucosa of right maxilla and left mandible surrounding dental implants that had been placed 8 years previously. Radiological examination revealed enhancing oral lesions and multiple cervical lymph nodes. Microscopic examination showed diffuse infiltration of large anaplastic cells with characteristic morphology of hallmark cells described in anaplastic large cell lymphoma. These cells were diffusely positive for CD30, CD3, CD4, CD2, CD5, CD7, TIA-1, and TCRβF1, but negative for CD20, CD8, CD45, EMA, ALK, and Epstein-Barr virus. T-cell monoclonality was detected in a TCRγ gene rearrangement study. This a unique case of mucosal CD30+ T-cell LPD with unusual presentation following dental implant.
Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Hye-Jung
HJ
Yoon
Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Ji-Young
JY
Choe
Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea junarplus@chol.com.
Yoon Kyung
YK
Jeon
D000368:Aged; D015921:Dental Implants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000096:biosynthesis; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000473:pathology*; D009059:Mouth Diseases / Q000209:etiology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*
D015921:Dental Implants; D017730:Ki-1 Antigen
anaplastic large cell lymphoma; breast implant–associated lymphoma; dental implant; mucosal CD30-positive T-cell lymphoproliferative disorder