[CHALLENGING THE OPTIMAL NUMBER OF RETRIEVED OOCYTES AND ITS IMPACT ON PREGNANCY AND LIVE BIRTH RATES IN IVF/ICSI CYCLES].
BACKGROUND
Large numbers of retrieved oocytes are associated with higher chances of having cryopreservation of embryos. However, the process entailed exposes women to increased risk for ovarian hyperstimulation syndrome. Furthermore, mild ovary stimulation protocols are more patient-friendly and with less adverse effects. Only limited reports exist on the significance of the number of retrieved oocytes achieved in a single stimulation cycle.


OBJECTIVE
To investigate the optimal number of retrieved oocytes to achieve pregnancy and live birth.


METHODS
This retrospective analysis included 1590 IVF cycles. Oocytes maturation, fertilization, cleavage, as well as pregnancy and live birth rates were analyzed according to the number of retrieved oocytes.


RESULTS
Oocyte maturation, fertilization and cleavage rates were lower in cycles with more than 10 retrieved oocytes compared with other groups. Live birth rates were highest when the number of retrieved oocytes was 11-15.


CONCLUSIONS
Retrieval of more than 15 oocytes was not associated with a significant increase in chances of conception and birth.


CONCLUSIONS
The better oocyte quality with 10 or less oocytes retrieved could be the result of a possible interference with the natural selection, or the minimized exposure of growing follicles to the potentially negative effects of ovarian stimulation. Although the average number of available embryos was higher when more than 10 oocytes were retrieved, achievement of more than 15 oocytes did not improve IVF outcome in terms of pregnancy and delivery rates.


CONCLUSIONS
Analysis of 1590 IVF cycles including the frozen-thawed transfers shows that the best outcomes were achieved with an optimal number of 11-15 oocytes.
Idit
I
Blais
Shirly
S
Lahav-Baratz
Mara
M
Koifman
Zofnat
Z
Wiener-Megnazi
Ron
R
Auslender
Martha
M
Dirnfeld
D000293:Adolescent; D000328:Adult; D001723:Birth Rate; D015925:Cryopreservation / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D050498:Live Birth; D008875:Middle Aged; D009865:Oocytes / Q000166:cytology*; D006080:Ovarian Follicle / Q000254:growth & development; D016471:Ovarian Hyperstimulation Syndrome / Q000453:epidemiology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D055815:Young Adult