Fusing Heterogeneous Data for Alzheimer's Disease Classification.
In multi-view learning, multimodal representations of a real world object or situation are integrated to learn its overall picture. Feature sets from distinct data sources carry different, yet complementary, information which, if analysed together, usually yield better insights and more accurate results. Neuro-degenerative disorders such as dementia are characterized by changes in multiple biomarkers. This work combines the features from neuroimaging and cerebrospinal fluid studies to distinguish Alzheimer's disease patients from healthy subjects. We apply statistical data fusion techniques on 101 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We examine whether fusion of biomarkers helps to improve diagnostic accuracy and how the methods compare against each other for this problem. Our results indicate that multimodal data fusion improves classification accuracy.
Medical Computing Laboratory, School of Computing, National University of Singapore, Singapore.
Parvathy Sudhir
PS
Pillai
Medical Computing Laboratory, School of Computing, National University of Singapore, Singapore.
Tze-Yun
TY
Leong
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D057225:Data Mining / Q000379:methods; D020000:Decision Support Systems, Clinical / Q000458:organization & administration*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D057286:Electronic Health Records / Q000458:organization & administration*; D006801:Humans; D000069550:Machine Learning; D008498:Medical Record Linkage / Q000379:methods; D059906:Neuroimaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D015415:Biomarkers