RELATIONSHIP BETWEEN ZINCEMIA, SUPEROXIDE DISMUTASE ACTIVITY AND MARKER OF OXIDATIVE STRESS IN WOMEN WITH BREAST CANCER.
BACKGROUND
studies show changes in zinc metabolism in women with breast cancer. This mineral has antioxidant action, and disorders in its biochemical parameters are related to poor prognosis of the disease and increase in the carcinogenic process.


OBJECTIVE
this study evaluated the activity of enzyme superoxide dismutase and biochemical parameters related to zinc, and investigated the existence of correlation between these variables and the marker of oxidative stress in these patients.


METHODS
this was a case-control study with 66 women aged between 20 and 50 years old, distributed into: case group (women with breast cancer, n = 34) and control group (healthy women, n = 32). Zinc intake was analyzed by three-day food diary, using Nutwin software, version 1.5. Plasma and erythrocyte zinc concentrations were determined by flame atomic absorption spectrophotometry method (λ = 213.9). Superoxide dismutase activity was assessed by Griess colorimetric method, and plasma thiobarbituric acid reactive substances (TBARS) were analyzed.


CONCLUSIONS
mean levels of zinc intake, superoxide dismutase and TBARS were higher than recommended for the study participants with statistical difference for enzyme superoxide dismutase (p < 0.05). Mean plasma and erythrocyte concentrations of zinc were reduced in both groups (p > 0.05).


CONCLUSIONS
therefore, it can be assumed that zinc intake in women with breast cancer does not impact plasma and erythrocyte concentrations of this mineral. High superoxide dismutase activity in women with breast cancer may be due to a compensatory mechanism of regulation via oxidative stress found in this disease.
Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina (Piauí).. dilina.marreiro@gmail.com.
Camila Guedes
CG
Borges de Araújo
Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina (Piauí).. dilina.marreiro@gmail.com.
Aldenora
A
Oliveira do Nascimento Holanda
Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina (Piauí).. dilina.marreiro@gmail.com.
Cinthya Vivianne
CV
de Souza Rocha
Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina (Piauí).. dilina.marreiro@gmail.com.
Ayla Patricia
AP
Soares do Nascimento
Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina (Piauí).. dilina.marreiro@gmail.com.
Camila Maria
CM
Simplício Revoredo
Department of Mastology and Gynecology, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí (Brazil).. dilina.marreiro@gmail.com.
Benedito
B
Borges da Silva
Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina (Piauí).. dilina.marreiro@gmail.com.
Nadir
N
do Nascimento Nogueira
Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina (Piauí).. dilina.marreiro@gmail.com.
Dilina
D
do Nascimento Marreiro
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers; D001943:Breast Neoplasms / Q000378:metabolism*; D016022:Case-Control Studies; D004032:Diet; D002149:Energy Intake; D004789:Enzyme Activation; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D055815:Young Adult; D015032:Zinc / Q000097:blood*
D000975:Antioxidants; D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase; D015032:Zinc