Efficacy of Spirulina platensis in improvement of the reproductive performance and easing teratogenicity in hyperglycemic albino mice.
OBJECTIVE
The present study evaluates the therapeutic efficacy of cell suspension of Spirulina platensis (SP) on estrous cycle, fetal development and embryopathy in alloxan (AXN) induced hyperglycemic mice.


METHODS
Diabetes was induced by intra-peritoneal administration of AXN. Mice with blood glucose level above 200 mg/dl were divided into Group I (control), Group II (diabetic control), Group III (diabetic control mice fed with SP), and Group IV (control mice fed with SP). Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.


RESULTS
In hyperglycemic mice, a significant (P < 0.05) increase in duration of diestrus (14.48%), estrus (84.21%), and metestrus (164.15%) with concomitant decrease in proestrus phase by 26.13% was recorded when compared with control. Reduction in litter count and survival of litter was 68.67% and 88.38%, respectively, whereas gestation length increased to 14.51% day in diabetic mice, but recovery in these parameters was observed (P < 0.05) when subjected to SP treatment. SP resulted in increased fertility rate from 77.5% to 82.5% and dropped off resorption of the fetus to 33.73% while the survival rate of offspring of diabetic mice went up to 88.89% from 83.61%.


CONCLUSIONS
These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.
Department of Zoology, Nagaland University, Lumami, Nagaland, India.
Pranay Punj
PP
Pankaj
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D006943:Hyperglycemia / Q000188:drug therapy*; D008098:Litter Size / Q000502:physiology; D051379:Mice; D011247:Pregnancy; D053545:Spirulina
D001786:Blood Glucose; D000496:Alloxan
Diabetes; Spirulina platensis; estrous cycle; fertility rate; fetal development; gestation length