FlyVar: a database for genetic variation in Drosophila melanogaster.
FlyVar is a publicly and freely available platform that addresses the increasing need of next generation sequencing data analysis in the Drosophila research community. It is composed of three parts. First, a database that contains 5.94 million DNA polymorphisms found in Drosophila melanogaster derived from whole genome shotgun sequencing of 612 genomes of D. melanogaster. In addition, a list of 1094 dispensable genes has been identified. Second, a graphical user interface (GUI) has been implemented to allow easy and flexible queries of the database. Third, a set of interactive online tools enables filtering and annotation of genomic sequences obtained from individual D. melanogaster strains to identify candidate mutations. FlyVar permits the analysis of next generation sequencing data without the need of extensive computational training or resources. Database URL: www.iipl.fudan.edu.cn/FlyVar.
Shanghai Key Lab of Intelligent Information Processing, School of Computer Science and Technology, Fudan University, Shanghai, China; wangfei@fudan.edu.cn.
Fei
F
Wang
Human Genome Sequencing Center, Department of Molecular and Human Genetics, and.
Lichun
L
Jiang
Shanghai Key Lab of Intelligent Information Processing, School of Computer Science and Technology, Fudan University, Shanghai, China;
Yong
Y
Chen
Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA;
Nele A
NA
Haelterman
Department of Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA; Howard Hughes Medical Institute.
Hugo J
HJ
Bellen
Human Genome Sequencing Center, Department of Molecular and Human Genetics, and wangfei@fudan.edu.cn.
Rui
R
Chen
D000818:Animals; D030541:Databases, Genetic; D004331:Drosophila melanogaster; D017344:Genes, Insect; D058977:Molecular Sequence Annotation; D011110:Polymorphism, Genetic; D014584:User-Computer Interface