New Labdane Diterpenes and Their Glycoside Derivatives from the Roots of Isodon adenantha.
Two new labdane-type diterpenes (adenanthic acids A and B; 1 and 2, resp.) and three new labdane diterpene glycosides (adenanthosides A-C; 3-5, resp.) were isolated from the roots of Isodon adenantha, together with 23 known constituents including seven diterpenoids (6-12), eight triterpenoids (13-20), one lignan glycoside (21), six steroids (22-27), and one ceramide (28). Their structures were elucidated by spectroscopic methods including extensive 2D-NMR techniques. Cytotoxicity and antibacterial activities of the samples were measured by the MTT method and the filter paper disc agar diffusion method. But none of them showed significant activities.
Institute of Materia Medica, College of Pharmacy and Chemistry, Dali University, Dali 671000, P. R. China, (phone: +86-872-2257316; fax: +86-872-2257401; (B. Jiang)).
La-Bin
LB
Wu
Institute of Materia Medica, College of Pharmacy and Chemistry, Dali University, Dali 671000, P. R. China, (phone: +86-872-2257316; fax: +86-872-2257401; (B. Jiang)).
Chao-Jiang
CJ
Xiao
Institute of Materia Medica, College of Pharmacy and Chemistry, Dali University, Dali 671000, P. R. China, (phone: +86-872-2257316; fax: +86-872-2257401; (B. Jiang)).
Xue
X
Jiang
Institute of Materia Medica, College of Pharmacy and Chemistry, Dali University, Dali 671000, P. R. China, (phone: +86-872-2257316; fax: +86-872-2257401; (B. Jiang)).
Lin
L
Qiu
Institute of Materia Medica, College of Pharmacy and Chemistry, Dali University, Dali 671000, P. R. China, (phone: +86-872-2257316; fax: +86-872-2257401; (B. Jiang)).
Xiang
X
Dong
Institute of Materia Medica, College of Pharmacy and Chemistry, Dali University, Dali 671000, P. R. China, (phone: +86-872-2257316; fax: +86-872-2257401; (B. Jiang)). dalinorthjiang@163.com.
Bei
B
Jiang
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D006027:Glycosides
Adenanthic acids A and B; Adenanthosides A - C; Isodon adenantha; Labdane derivatives