Novel regulation of aflatoxin B1 biosynthesis in Aspergillus flavus by piperonal.
The present study investigated its inhibitory role in aflatoxin (AF) biosynthesis. Treating only AFB1- and B2-producing Aspergillus flavus with piperonal completely inhibited AFB1 production with high sclerotial formation, resulting in 20-fold higher AFG2 production. On the other hand, benzodioxole and eugenol suppressed AFB1 production without AFG formation, while methyleugenol showed potent inhibition of AFB1 production with slight production of AFG1. These results indicate that natural products may change aflatoxin biosynthesis, and highlight a novel regulation of AFG2 production by piperonal. It is the first report for chemical regulation on AFG2 production in non-AFG producing-aspergilli.
a School of Applied Sciences , Kyungpook National University , Daegu , Republic of Korea.
Eun-Sil
ES
Park
a School of Applied Sciences , Kyungpook National University , Daegu , Republic of Korea.
In Kyung
IK
Bae
b National Agricultural Products Quality Management Service , Kimcheon , Republic of Korea.
Ho Jin
HJ
Kim
a School of Applied Sciences , Kyungpook National University , Daegu , Republic of Korea.
Sung-Eun
SE
Lee
D016604:Aflatoxin B1 / Q000096:biosynthesis*; D000348:Aflatoxins / Q000378:metabolism; D001231:Aspergillus flavus / Q000187:drug effects* / Q000378:metabolism*; D001547:Benzaldehydes / Q000494:pharmacology*; D052117:Benzodioxoles / Q000494:pharmacology*; D005054:Eugenol / Q000031:analogs & derivatives / Q000494:pharmacology
D000348:Aflatoxins; D001547:Benzaldehydes; D052117:Benzodioxoles; C005223:methyleugenol; C029754:aflatoxin G2; D005054:Eugenol; D016604:Aflatoxin B1; C005454:piperonal
Aspergillus flavus; Piperonal; aflatoxin B1 biosynthesis; aflatoxin G2