[Development of anti-cancer drugs mediated by apoptosis and autophagy].
Apoptosis and autophagy usually function to eliminate damaged cells and damaged proteins, respectively. Dysfunction of these events induces oncogenesis and cancer development. Therefore, small compounds that activate apoptosis and autophagy are good candidates for anti-cancer chemotherapeutics to combat cancers. This review focuses on recent advances in apoptosis/autophagy and their relationship with tumorigenesis.
Shigeomi
S
Shimizu
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D001343:Autophagy / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D055808:Drug Discovery; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000502:physiology; D051379:Mice; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000502:physiology
D000970:Antineoplastic Agents; D051034:Inhibitor of Apoptosis Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D053221:TNF-Related Apoptosis-Inducing Ligand