Increased Expressions of Integrin Subunit β1, β2 and β3 in Patients with Acute Infection.
OBJECTIVE
Our previous studies have shown that integrin subunits β1, β2 and β3 were the core proteins of venous thrombi and potential useful biomarker of venous thromboembolism (VTE). Patients with acute infection have a high risk of VTE. In this study we explored that is there any relevance between core proteins and acute infection.


METHODS
A total of 230 patients (112 females) with clinically proven acute infection in the emergency unit were recruited into this study, meanwhile 230 patients without acute infection matched in sex and age were recruited as control group. Flow cytometry was done to measure the expressions of blood integrin β1, β2, β3 and cellular immunity (CD3, CD4, CD8, CD4/CD8, CD16CD56 and CD19). The association degree between increased core proteins and acute infection was analyzed by calculating the relative risk (RR).


RESULTS
The expression of integrin β1, β2 and β3 was markedly increased in patients with acute infection (P=0.000, 0.000 and 0.015, respectively). The relative risk ratio (RR) of increased integrin β1, β2 and β3 in acute infection patients was 1.424 (95%CI: 1.156-1.755, P=0.001), 1.535 (95%CI: 1.263-1.865, P=0.000) and 1.20 (95%CI: 0.947-1.521, P=0.148), respectively. Combined integrin β1, β2 and β3 analysis showed that the relative risk ratio (RR) of increased in patients with acute infection was 2.962 (95%CI: 1.621-5.410, P=0.001), and this relative risk (RR) rise to 3.176 (95%CI: 1.730-5.829, P=0.000) in patients with respiratory tract infection (RTI).


CONCLUSIONS
As the core proteins of venous thrombi, integrinβ1, β2 and β3 were markedly increased expression in patients with acute infection, which maybe explain the increased risk of VTE in acute infection patients. A weakened immune system could be the basic condition of VTE occurrence.
1. Department of Emergency Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China;
Yanli
Y
Song
2. Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China;
Lemin
L
Wang
3. Department of Experimental Diagnosis, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Fan
F
Yang
1. Department of Emergency Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China;
Xianzheng
X
Wu
2. Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China;
Qianglin
Q
Duan
2. Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China;
Zhu
Z
Gong
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D018821:CD18 Antigens / Q000378:metabolism*; D016022:Case-Control Studies; D004636:Emergency Service, Hospital; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D006801:Humans; D007239:Infections / Q000097:blood* / Q000150:complications; D019012:Integrin beta1 / Q000378:metabolism*; D039661:Integrin beta3 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000097:blood / Q000150:complications; D012306:Risk; D012871:Skin Diseases / Q000097:blood / Q000150:complications; D014552:Urinary Tract Infections / Q000097:blood / Q000150:complications; D054556:Venous Thromboembolism / Q000097:blood* / Q000150:complications; D055815:Young Adult
D015415:Biomarkers; D018821:CD18 Antigens; D005338:Fibrin Fibrinogen Degradation Products; D019012:Integrin beta1; D039661:Integrin beta3; C036309:fibrin fragment D
acute infection; core protein; integrinβ1; integrinβ2; integrinβ3; venous thromboembolism