Aloe vera Gel: Effective Therapeutic Agent against Multidrug-Resistant Pseudomonas aeruginosa Isolates Recovered from Burn Wound Infections.
Objective. Aloe vera is an herbal medicinal plant with biological activities, such as antimicrobial, anticancer, anti-inflammatory, and antidiabetic ones, and immunomodulatory properties. The purpose of this study was investigation of in vitro antimicrobial activity of A. vera gel against multidrug-resistant (MDR) Pseudomonas aeruginosa isolated from patients with burn wound infections. Methods. During a 6-month study, 140 clinical isolates of P. aeruginosa were collected from patients admitted to the burn wards of a hospital in Tehran, Iran. Antimicrobial susceptibility test was carried out against the pathogens using the A. vera gel and antibiotics (imipenem, gentamicin, and ciprofloxacin). Results. The antibiogram revealed that 47 (33.6%) of all isolates were MDR P. aeruginosa. The extract isolated from A. vera has antibacterial activity against all of isolates. Also, 42 (89.4%) isolates were inhibited by A. vera gel extract at minimum inhibitory concentration (MIC) ≤ 200 µg/mL. MIC value of A. vera gel for other isolates (10.6%) was 800 µg/mL. All of MDR P. aeruginosa strains were inhibited by A. vera at similar MIC50 and MIC90 200 µg/mL. Conclusion. Based on our results, A. vera gel at various concentrations can be used as an effective antibacterial agent in order to prevent wound infection caused by P. aeruginosa.
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Science, Tehran 1985717443, Iran.
Mehdi
M
Goudarzi
WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran 1316943551, Iran.
Maryam
M
Fazeli
Department of Medical Laboratory Sciences, School of Paramedicine, Qazvin University of Medical Sciences, Qazvin 1651135779, Iran.
Mehdi
M
Azad
Department of Medical Mycology, Pasteur Institute of Iran, Tehran 1316943551, Iran.
Sima Sadat
SS
Seyedjavadi
Department of Medical Laboratory Sciences, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
Reza
R
Mousavi