Overview of Nrf2 as Therapeutic Target in Epilepsy.
Oxidative stress is a biochemical state of imbalance in the production of reactive oxygen and nitrogen species and antioxidant defenses. It is involved in the physiopathology of degenerative and chronic neuronal disorders, such as epilepsy. Experimental evidence in humans and animals support the involvement of oxidative stress before and after seizures. In the past few years, research has increasingly focused on the molecular pathways of this process, such as that involving transcription factor nuclear factor E2-related factor 2 (Nrf2), which plays a central role in the regulation of antioxidant response elements (ARE) and modulates cellular redox status. The aim of this review is to present experimental evidence on the role of Nrf2 in this neurological disorder and to further determine the therapeutic impact of Nrf2 in epilepsy.
Laboratory of Neurochemistry (Neurosciences), National Institute of Pediatrics, D.F. 04530, Mexico. lgranados_2000@yahoo.com.mx.
Liliana
L
Carmona-Aparicio
Laboratory of Neuroplasticity and Neurodegeneration, Cinvestav, D.F. 07360, Mexico. cau9@yahoo.com.
Claudia
C
Pérez-Cruz
Laboratory of Physiology of the Reticular Formation, National Institute of Neurology and Neurosurgery-MVS, D.F. 14269, Mexico. cztecua@yahoo.com.mx.
Cecilia
C
Zavala-Tecuapetla
Laboratory of Neurochemistry (Neurosciences), National Institute of Pediatrics, D.F. 04530, Mexico. lgranados_2000@yahoo.com.mx.
Leticia
L
Granados-Rojas
Laboratory of Pharmacology, National Institute of Pediatrics, D.F. 04530, Mexico. lili_rives@yahoo.com.
Liliana
L
Rivera-Espinosa
Service of Endocrinology, National Institute of Pediatrics, D.F. 04530, Mexico. hortenciamontesinoscorrea@yahoo.com.
Hortencia
H
Montesinos-Correa
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, D.F. 04150, Mexico. jdamian@email.ifc.unam.mx.
Jacqueline
J
Hernández-Damián
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, D.F. 04150, Mexico.
José
J
Pedraza-Chaverri
Department of Comparative Biology, Faculty of Sciences, National Autonomous University of Mexico, D.F. 04150, Mexico. aris_sampieri@yahoo.com.mx.
Aristides
A
Sampieri
Laboratory of Neurochemistry (Neurosciences), National Institute of Pediatrics, D.F. 04530, Mexico. lgranados_2000@yahoo.com.mx.
Elvia
E
Coballase-Urrutia
Laboratory of Neurochemistry (Neurosciences), National Institute of Pediatrics, D.F. 04530, Mexico. lgranados_2000@yahoo.com.mx.
Noemí
N
Cárdenas-Rodríguez
D000818:Animals; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D051267:NF-E2-Related Factor 2 / Q000737:chemistry / Q000378:metabolism*; D018384:Oxidative Stress; D015398:Signal Transduction
D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human
Nrf2; epilepsy; stress oxidative; transcription factor nuclear