[Prevalence and echocardiographic feature of bicuspid aortic valve in patients with severe aortic stenosis: a echocardiography database analysis].
OBJECTIVE
To evaluate the accuracy of echocardiography in identifying aortic valve structures and determine the prevalence of bicuspid aortic valves (BAV) in severe aortic stenosis (AS) population to provide useful information for transcatheteraortic valve replacement (TAVR).


METHODS
A total of 300 AS patients undergoing surgical aortic valve replacement were included to determine the accuracy of transthoracic echocardiography in indentifying BAV from January 2009 to July 2013. The echocardiographic data of our hospital from 2004 to 2012 was retrospectively reviewed. 1 371 patients with isolated severe native aortic valves stenosis were consecutively enrolled.


RESULTS
The aortic valve structures could be defined by transthoracic echocardiography in 75.7% (227/300) patients with severe AS. With BAV diagnosis during operation as gold standard, the accuracy of transthoracic echocardiography in identifying BAV was 89.4% (203/227). Among 1 371 patients with severe AS, the percentage of BAV in patients aged <40 years, aged 40-59 years, aged 60-69 years, aged 70-79 years and aged ≥ 80 years was 60.0% (57/95), 57.5% (262/456), 42.7% (184/431), 43.2% (133/308) and 21.0% (17/81), respectively. Incidence of BAV in patients with degenerative calcific valve was significant higher than in those with rheumatic heart disease (44.3% (552/1 246) vs. 4.0% (3/76), P<0.01). Proportion of combined aortic regurgitation ≥ grade 2 was significantly lower, ascending aortic diameter was larger and left ventricular end-diastolic dimension was smaller in BAV patients compared to severe AS patients with tricuspid valves (all P<0.01), while aortic valve annuals diameter and accompanying cardiovascular diseases between BAV and tricuspid aortic valve groups were similar (all P>0.05).


CONCLUSIONS
Transthoracic echocardiography could accurately identify aortic valve structures in about 76% patients. BAV is common in severe AS patients across all ages. These results provide important information for the popularization of TVAR.
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Wenzhi
W
Pan
Mingfei
M
Li
Daxin
D
Zhou
Lihua
L
Guan
Leilei
L
Cheng
Email: ge.junbo2@zs-hospital.sh.cn.
Junbo
J
Ge
D001011:Aorta; D001021:Aortic Valve / Q000002:abnormalities; D001024:Aortic Valve Stenosis; D000082882:Bicuspid Aortic Valve Disease; D004452:Echocardiography; D006349:Heart Valve Diseases; D006350:Heart Valve Prosthesis; D006801:Humans; D015994:Incidence; D015995:Prevalence; D012189:Retrospective Studies