[Bacterial infection after orthotopic liver transplantation].
BACKGROUND
The authors reviewed the prevalence of postoperative infections, the results of bacterium cultures, and the incidence of multidrug resistance in their liver transplanted patients during a period between 2003 and 2012.


OBJECTIVE
The aim of this study was to analyse risk factors and colonisations of bacterial infections.


METHODS
The files of 408 patients (281 bacterium cultures) were reviewed.


RESULTS
Of the 408 patients 70 had a postoperative infection (17%); 58 patients (14.2%) had positive and 12 patients (2.9%) negative bacterial culture results. Cholangitis was found in 7 cases (12.1%), abdominal infection in 17 cases (29.3%), and pulmonary infection in 28 cases (48.3%). Postoperative infection was more frequent in patients with initial poor graft function, acute renal insufficiency, biliary complication, and in those with intraabdominal bleeding. The 1-, 3- and 5-year cumulative survival of patients who had infection was 70%, 56% and 56%, respectively, whereas the cumulative survival data of patients without infection was 94%, 87% and 85%, respectively (p<0.001). Multidrug resistance was found in 56% of the positive cultures, however, the one-year survival was not different in patients who had multidrug resistance positive and negative bacterial infection (both 70.2%).


CONCLUSIONS
Infection control must target the management of multidrug resistance microbes through encouraging prevention, hygienic, and isolation rules, improving the operative, transfusion, and antimicrobial policy in a teamwork setting.
Sebészeti Intézet, Szervtranszplantációs nem önálló Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Móricz Zs. krt. 22., 4032.
Balázs
B
Nemes
Fanni
F
Gelley
Eszter
E
Dabasi
György
G
Gámán
Imre
I
Fehérvári
Dénes
D
Görög
László
L
Kóbori
János
J
Fazakas
Eszter
E
Vitális
Attila
A
Doros
Zsuzsanna
Z
Gálffy
Zoltán
Z
Máthé
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D001803:Blood Transfusion / Q000592:standards; D002761:Cholangitis / Q000150:complications / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology; D006085:Graft Survival; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D017053:Infection Control / Q000379:methods*; D016031:Liver Transplantation / Q000009:adverse effects / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications / Q000382:microbiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis
bacterial infection; multidrug resistance; multidrug-rezisztencia; májátültetés; orthotopic liver transplantation; posztoperatív fertőzés; sepsis; survival; szepszis; túlélés