Ertapenem Prophylaxis Associated With an Increased Risk of Clostridium difficile Infection Among Surgical Patients.
A case-control study was conducted to determine risk factors for hospital-onset Clostridium difficile infection among patients admitted to 2 surgical units. Ertapenem prophylaxis was significantly associated with C. difficile infection risk (odds ratio, 3.13 [95% CI, 1.13-8.68], P=.028) and may offer an antimicrobial stewardship target among surgical patients.
1Department of Hospital Epidemiology and Infection Control,University of California San Francisco Medical Center,San Francisco,California.
Seungwon
S
Lee
2Department of Epidemiology and Biostatistics,University of California San Francisco,San Francisco,California.
Priya
P
Prasad
3Department of Surgery,University of California San Francisco,San Francisco,California.
Matthew
M
Lin
1Department of Hospital Epidemiology and Infection Control,University of California San Francisco Medical Center,San Francisco,California.
Susan
S
Garritson
1Department of Hospital Epidemiology and Infection Control,University of California San Francisco Medical Center,San Francisco,California.
Amy
A
Nichols
4Division of Infectious Diseases,Department of Medicine,University of California San Francisco,San Francisco,California.
Catherine
C
Liu
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016022:Case-Control Studies; D016360:Clostridioides difficile / Q000302:isolation & purification; D003015:Clostridium Infections / Q000453:epidemiology*; D003428:Cross Infection / Q000453:epidemiology*; D000077727:Ertapenem; D005260:Female; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011183:Postoperative Complications / Q000175:diagnosis*; D012189:Retrospective Studies; D012307:Risk Factors; D047090:beta-Lactams / Q000008:administration & dosage / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D000077727:Ertapenem