Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide.
The recurring issue with cell penetrating peptides is how to increase direct translocation vs. endocytosis, to avoid premature degradation. Acylation by a cis unsaturated chain (C22:6) of a short cationic peptide provides a new rational design to favour diffuse cytosolic and dense Golgi localisations.
Sorbonne Universités, UPMC Univ Paris 06, Laboratoire des Biomolécules, UMR 7203, 4, Place Jussieu 75005, Paris, France. solange.lavielle@upmc.fr fabienne.burlina@upmc.fr.
J-M
JM
Swiecicki
M
M
Di Pisa
F
F
Lippi
S
S
Chwetzoff
C
C
Mansuy
G
G
Trugnan
G
G
Chassaing
S
S
Lavielle
F
F
Burlina
D001120:Arginine / Q000378:metabolism*; D001692:Biological Transport; D003600:Cytosol / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D055666:Lipopeptides / Q000378:metabolism*
D055666:Lipopeptides; D001120:Arginine