Normal liver enzymes are correlated with severity of metabolic syndrome in a large population based cohort.
Key features of the metabolic syndrome are insulin resistance and diabetes. The liver as central metabolic organ is not only affected by the metabolic syndrome as non-alcoholic fatty liver disease (NAFLD), but may contribute to insulin resistance and metabolic alterations. We aimed to identify potential associations between liver injury markers and diabetes in the population-based Heinz Nixdorf RECALL Study. Demographic and laboratory data were analyzed in participants (n = 4814, age 45 to 75 y). ALT and AST values were significantly higher in males than in females. Mean BMI was 27.9 kg/m(2) and type-2-diabetes (known and unkown) was present in 656 participants (13.7%). Adiponectin and vitamin D both correlated inversely with BMI. ALT, AST, and GGT correlated with BMI, CRP and HbA1c and inversely correlated with adiponectin levels. Logistic regression models using HbA1c and adiponectin or HbA1c and BMI were able to predict diabetes with high accuracy. Transaminase levels within normal ranges were closely associated with the BMI and diabetes risk. Transaminase levels and adiponectin were inversely associated. Re-assessment of current normal range limits should be considered, to provide a more exact indicator for chronic metabolic liver injury, in particular to reflect the situation in diabetic or obese individuals.
Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen.
Julia
J
Kälsch
Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen.
Lars P
LP
Bechmann
Department of Bioinformatics, Straubing Center of Science, University of Applied Science Weihenstephan-Triesdorf.
Dominik
D
Heider
Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen.
Jan
J
Best
1] Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen [2] Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK.
Paul
P
Manka
Department of Cardiology, West-German Heart Center, University Hospital, University Duisburg-Essen.
Hagen
H
Kälsch
Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen.
Jan-Peter
JP
Sowa
Institute of Medical Informatics, Biometry and Epidemiology, University Hospital, University Duisburg-Essen.
Susanne
S
Moebus
Institute of Medical Informatics, Biometry and Epidemiology, University Hospital, University Duisburg-Essen.
Uta
U
Slomiany
Institute of Medical Informatics, Biometry and Epidemiology, University Hospital, University Duisburg-Essen.
Karl-Heinz
KH
Jöckel
Department of Cardiology, West-German Heart Center, University Hospital, University Duisburg-Essen.
Raimund
R
Erbel
Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen.
Guido
G
Gerken
Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen.
Ali
A
Canbay
D052242:Adiponectin / Q000097:blood; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D008875:Middle Aged; D012372:ROC Curve; D014807:Vitamin D / Q000097:blood
D052242:Adiponectin; D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D015415:Biomarkers; D006442:Glycated Hemoglobin; D014807:Vitamin D; C499918:ADIPOQ protein, human; C517652:hemoglobin A1c protein, human