Interleukin 17-Mediated Host Defense against Candida albicans.
Candida albicans is part of the normal microbiota in most healthy individuals. However, it can cause opportunistic infections if host defenses are breached, with symptoms ranging from superficial lesions to severe systemic disease. The study of rare congenital defects in patients with chronic mucocutaneous candidiasis led to the identification of interleukin-17 (IL-17) as a key factor in host defense against mucosal fungal infection. Experimental infections in mice confirmed the critical role of IL-17 in mucocutaneous immunity against C. albicans. Research on mouse models has also contributed importantly to our current understanding of the regulation of IL-17 production by different cellular sources and its effector functions in distinct tissues. In this review, we highlight recent findings on IL-17-mediated immunity against C. albicans in mouse and man.
Section of Immunology, Institute of Virology, University of Zürich, Winterthurerstrasse 266a, Zürich, CH-8057, Switzerland. florian.sparber@uzh.ch.
Florian
F
Sparber
Section of Immunology, Institute of Virology, University of Zürich, Winterthurerstrasse 266a, Zürich, CH-8057, Switzerland. salome.leibundgut-landmann@uzh.ch.
Salomé
S
LeibundGut-Landmann
chronic mucocutaneous candidiasis; interleukin 17; mouse models