Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.
The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.
1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;
Renfa
R
Liu
1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China; ; 3. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
Lijia
L
Jing
2. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;
Dong
D
Peng
3. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
Yong
Y
Li
2. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;
Jie
J
Tian
1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;
Zhifei
Z
Dai
D000818:Animals; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry*; D005260:Female; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D061088:Photoacoustic Techniques / Q000295:instrumentation / Q000379:methods*; D010789:Phototherapy; D011859:Radiography; D013440:Sulfides / Q000737:chemistry*
D013440:Sulfides; D008345:Manganese; D003300:Copper
Copper sulfide nanoparticles; Magnatic resonance imaging; Nanotheranostic agent; Photoacoustic imaging; Photothermal therapy.