Endogenous thrombin potential in polycystic ovary syndrome: the association to body mass index, insulin resistance, and inflammation.
OBJECTIVE
The objective of this study is to investigate plasma endogenous thrombin generation in four different phenotypes of polycystic ovary syndrome (PCOS) defined by Body Mass Index (BMI) and insulin resistance (IR). PCOS is diagnosed according to the Rotterdam criteria.


METHODS
Multicenter cross-sectional study.


METHODS
Two major University Hospitals in the Capital region of Denmark.


METHODS
Hundred forty-eight European women with PCOS were consecutively recruited during April 2010-February 2012. Clinical examination, blood sampling, and DEXA scan were performed.


METHODS
Endogenous thrombin potential (ETP).


RESULTS
PCOS women with phenotype BMI > 25 + IR have increased potential of thrombin generation. ETP is associated with total body fat mass, IR, and CRP.


CONCLUSIONS
Obese and insulin resistant women with PCOS have elevated level of ETP corresponding to increased risk of CVD. ETP is related to well-known CVD risk factors in PCOS but not in general to the Rotterdam criteria.
a Department of Gynaecology and Obstetrics, Faculty of Health and Medical Sciences , Herlev University Hospital, Copenhagen University , Herlev , Denmark .
Mubeena
M
Aziz
b Unit for Thrombosis Research, Institute of Public Health, University of Southern Denmark , Esbjerg , Denmark .
Johannes J
JJ
Sidelmann
c Department of Endocrinology, Faculty of Health and Medical Sciences , Herlev University Hospital, Copenhagen University , Herlev , Denmark , and.
Marie Louise Muff
ML
Wissing
d Department of Gynaecology and Obstetrics, Faculty of Health and Medical Sciences , Holbaek University Hospital, Copenhagen University , Holbaek , Denmark.
Jens
J
Faber
a Department of Gynaecology and Obstetrics, Faculty of Health and Medical Sciences , Herlev University Hospital, Copenhagen University , Herlev , Denmark .
Sven O
SO
Skouby
D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000000981:diagnostic imaging; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000276:immunology; D008076:Cholesterol, HDL / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D016014:Linear Models; D050177:Overweight / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism; D055105:Waist Circumference; D055815:Young Adult
D008076:Cholesterol, HDL; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D013739:Testosterone; D002097:C-Reactive Protein; D013917:Thrombin
Endogenous thrombin generation; PCOS; inflammation; insulin resistance; obesity