Pulmonary Extranodal Marginal Zone Lymphoma with Macroglobulinemia and Mixed Cryoglobulinemia Developed in a Patient with Chronic Hepatitis C.
We report a 65-year-old woman with a chronic hepatitis C virus infection who developed pulmonary extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissues complicated with macroglobulinemia and mixed cryoglobulinemia. She was treated with immunochemotherapy which resulted in the reduction of both the tumors and the serum immunoglobulin (Ig) M level. This case exemplifies an extensive stimulation upon immune system with derangement in the production of immunoglobulines associated with EMZL, and suggests that it is necessary to consider the possibility of B-cell lymphoma when IgM paraprotein is detected.
Internal Medicine, St. Luke's International Hospital, Japan.
Chisun
C
Min
Takakazu
T
Higuchi
Ryosuke
R
Koyamada
Norihiro
N
Yamaguchi
Sadamu
S
Okada
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003449:Cryoglobulinemia / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D007167:Immunotherapy; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D009194:Myeloma Proteins / Q000302:isolation & purification; D015514:Oncogene Proteins, Fusion / Q000378:metabolism*; D013812:Therapeutics; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
C415943:API2-MALT1 fusion protein, human; D000970:Antineoplastic Agents; D007075:Immunoglobulin M; D009194:Myeloma Proteins; D015514:Oncogene Proteins, Fusion; C085016:multiple myeloma M-proteins