Polymorphisms in DNA repair and multidrug resistance genes among Sindhis of Central India.
Polymorphisms in DNA repair and multidrug resistance genes might contribute to interindividual and interethnic differences in DNA repair capacity and drug disposition respectively. In the present study, we determined the allele and genotype frequencies of four single nucleotide polymorphisms (SNPs) located in the DNA repair genes, XRCC1, XRCC3, XPD, OGG1, namely XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, and OGG1 Ser326Cys, respectively and two SNPs located in the multidrug resistance gene, ABCB1, namely ABCB1 C3435T and ABCB1 C1236T, in 33-35 healthy and unrelated Sindhi individuals, residing in the Vidarbha region of Central India and compared them with the Maharashtrian population from the same geographical region and some other HapMap populations from the HapMap database. The study findings reveal that the Indian Sindhis are closely related to the Maharashtrians as well as Utah residents with Northern and Western European ancestry and Gujarati Indians in Houston, Texas in the HapMap database.
Kolkata Zonal Laboratory, CSIR-National Environmental Engineering Research Institute, i-8 Sector-C, East Kolkata Area Development Project, Kolkata 700107, India; Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India. Electronic address: sr_pramanik@neeri.res.in.
Sreemanta
S
Pramanik
Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India.
Subin T
ST
Surendran
Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India.
Sathishkumar
S
Arumugam
Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India.
Saravana
S
Devi
Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India.
Kannan
K
Krishnamurthi
Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India.
Tapan
T
Chakrabarti
D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics*; D000328:Adult; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000208:ethnology* / Q000235:genetics; D000076105:X-ray Repair Cross Complementing Protein 1; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*; D055815:Young Adult
C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human
Cancer; DNA repair; Drug disposition; Indian Sindhis; Multidrug resistance; SNP