Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye.
OBJECTIVE
To study the repeatability and reproducibility of tear meniscus height (TMH) measurements obtained with a keratograph and Fourier domain optical coherence tomography (FD-OCT) and to assess their agreement in patients with dry eye.


METHODS
Sixty-four eyes with dry eye were analyzed by the Schirmer test, tear breakup time test, and fluorescein corneal staining. The TMH was measured 3 times using both devices by 2 different examiners. The repeatability and reproducibility of measurements were assessed by within-subject standard deviation (Sw), repeatability (2.77 Sw), coefficient of variation (CoV), and intraclass correlation coefficient.


RESULTS
The TMH measured with the keratograph and FD-OCT was 0.232 ± 0.074 mm and 0.308 ± 0.129 mm, respectively (P < 0.01). A close correlation was found between the TMH measured with the keratograph and FD-OCT (r = 0.343). There was a negative correlation between the mean TMH and differences in the TMH measured with the keratograph and FD-OCT (r = 0.359). Both measurements correlated with the Schirmer test score, tear breakup time, and corneal staining score with P < 0.01. Intraexaminer CoV, 2.77 Sw, and intraclass correlation coefficient of the TMH were <6.5%, <0.059 mm, and >0.986, respectively, and interexaminer CoV and 2.77 Sw were 5.58% and 0.039 mm, respectively.


CONCLUSIONS
Although the TMH measured with the keratograph tended to be lower than that measured with FD-OCT, the TMH measured with the keratograph closely correlated with the TMH measured with FD-OCT and conventional tests and had good repeatability and reliability.
*Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea; and †Department of Ophthalmology and Visual Science, St Paul's Hospital, College of Medicine, The Catholic University of Korea.
Jiwon
J
Baek
Sang Hee
SH
Doh
Sung Kun
SK
Chung
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation; D015352:Dry Eye Syndromes / Q000175:diagnosis*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D015203:Reproducibility of Results; D013666:Tears / Q000737:chemistry*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology