Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease.
For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago, LDs are presently considered an active subcellular organelle especially designed for assembling, storing and subsequently supplying lipids for generating energy and membrane synthesis (and in the case of hepatocytes for VLDL secretion). LDs also play a central role in many other cellular functions such as viral assembly and protein degradation. Here, we have explored the structural and functional changes that occur in hepatic and adipose tissue LDs following chronic ethanol consumption in relation to their role in the pathogenesis of alcoholic liver injury.
Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS). 0.
Sathish Kumar
SK
Natarajan
Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS). 0.
Karuna
K
Rasineni
Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS). 0.
Murali
M
Ganesan
Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS). 0.
Dan
D
Feng
Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS). 0.
Benita L
BL
McVicker
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota. United States.
Mark A
MA
McNiven
Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS). 0.
Natalia A
NA
Osna
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center. 0.
Justin L
JL
Mott
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center. 0.
Carol A
CA
Casey
Veterans Affairs Nebraska Western Iowa Health Care System, Research Service (151), 4101 Woolworth Avenue, Omaha, Nebraska, 68105. United States.
Kusum K
KK
Kharbanda
D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001343:Autophagy; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D066292:Lipid Droplets / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000378:metabolism* / Q000473:pathology; D059748:Proteolysis; D015398:Signal Transduction
ATGL; HCV; HSL; Liver; MiRs; Src; TGH; VLDL; adipose; alcohol; betaine; dynamin; lipases; lipid; lipid droplet; lipolysis; lipophagy; perilipin; phosphatidylcholine; phosphatidylethanolamine; rab; steatosis; triglycerides