Establishment and management of a lung cancer biobank in Eastern China.
BACKGROUND
The prevalence of lung cancer, a highly complex neoplasm, increases annually. Thus, a lung cancer biobank, which stores lung cancer tissue and blood matched according to standard methods, is needed to advance lung cancer research and develop promising therapies.


METHODS
To accomplish this aim, we implemented standardized procedures for tissue samples and patient information acquired from consenting donors. The banked tissue includes blood, pleural effusions, and surgical resection samples. An independent information management system was used to match samples and collect data, including clinical cancer manifestation, laboratory tests, and de-identified data about cancer patients.


RESULTS
From 2009 to 2013, more than 2000 lung cancer cases were collected. At this time, we have more than 10 000 biological samples stored in our biobank. DNA, ribonucleic acid (RNA), and protein quality were confirmed to be appropriate for clinical and basic research.


CONCLUSIONS
Our standardized, large-scale lung cancer biobank offers high quality cancer research samples for China and the world.
Department of Biaobank, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China ; Department of Pathology, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Keke
K
Yu
Department of Pathology, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Jie
J
Zhang
Department of Biaobank, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Xin
X
Li
Department of Biaobank, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Lei
L
Xu
Department of Biaobank, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China ; Department of Pathology, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Ye
Y
Zhang
Department of Biaobank, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China ; Department of Pathology, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Jie
J
Xing
Department of Pathology, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Jinchen
J
Shao
Department of Pathology, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Lei
L
Zhu
Department of Pathology, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Jinguo
J
Liu
Department of Pathology, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Lanxiang
L
Zhao
Department of Biaobank, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China ; Department of Pulmonary Medcine, Shanghai Chest Hospital, Shanghai JiaoTong University Shanghai, China.
Baohui
B
Han
Biobank; information; lung cancer; standardization