Additive effect of Lygodium venustum SW. in association with gentamicin.
The aim of this work was to evaluate the interactions between gentamicin and the ethanol extract of the fern Lygodium venustum SW (EELV). The ethanol extract of L. venustum was obtained, the phytocompounds were identified and the EELV was assayed by the checkerboard method with gentamicin against two bacterial strains multiresistant to antibiotics. The antibiotic activity of gentamicin, when associated with the extract, was enhanced in an additive manner against both strains. The results indicated that L. venustum can be a source of secondary metabolites to be used in association with antibiotics as aminoglycosides in the antibiotic chemotherapy against resistant bacteria.
a Laboratório de Microbiologia e Biologia Molecular , Universidade Regional do Cariri , Crato , Brasil.
Maria F B
MF
Morais-Braga
a Laboratório de Microbiologia e Biologia Molecular , Universidade Regional do Cariri , Crato , Brasil.
Teógenes M
TM
Souza
a Laboratório de Microbiologia e Biologia Molecular , Universidade Regional do Cariri , Crato , Brasil.
Karla K A
KK
Santos
a Laboratório de Microbiologia e Biologia Molecular , Universidade Regional do Cariri , Crato , Brasil.
Gláucia M M
GM
Guedes
a Laboratório de Microbiologia e Biologia Molecular , Universidade Regional do Cariri , Crato , Brasil.
Jacqueline C
JC
Andrade
a Laboratório de Microbiologia e Biologia Molecular , Universidade Regional do Cariri , Crato , Brasil.
Saulo R
SR
Tintino
a Laboratório de Microbiologia e Biologia Molecular , Universidade Regional do Cariri , Crato , Brasil.
Celestina E
CE
Sobral-Souza
b Laboratório de Pesquisa em Produtos Naturais , Universidade Regional do Cariri , Crato , Brasil.
José G M
JG
Costa
c Laboratório de Paleontologia da , Universidade Regional do Cariri , Crato , Brasil.
Antonio A F
AA
Saraiva
a Laboratório de Microbiologia e Biologia Molecular , Universidade Regional do Cariri , Crato , Brasil.
Henrique D M
HD
Coutinho
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry; D029624:Ferns / Q000737:chemistry*; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010936:Plant Extracts; D000431:Ethanol
Lygodium venustum; checkerboard method; ethanol extract; gentamicin