"Two-Step" Raman Imaging Technique To Guide Chemo-Photothermal Cancer Therapy.
Graphene oxide-wrapped gold nanorods (GO@AuNRs) offer efficient drug delivery as well as NIR laser photothermal therapy (PTT) in vitro and in vivo. However, no real-time observation of drug release has been reported to better understand the synergy of chemotherapy and PTT. Herein, surface-enhance Raman spectroscopy (SERS) is employed to guide chemo-photothermal cancer therapy by a two-step mechanism. In the presence of GO as an internal standard, SERS signals of DOX (doxorubicin) loaded onto GO@AuNRs are found to be pH-responsive. Both DOX and GO show strong SERS signals before the DOX@GO@AuNRs are endocytic. However, when the DOX@GO@AuNRs enter acidic microenvironments such as endosomes and/or lysosomes, the DOX signals start decreasing while the GO signals remain the same. This plasmonic antenna could be used to identify the appropriate time to apply the PTT laser during chemo-photothermal therapy.
Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Kingdom of Saudi Arabia).
Lin
L
Deng
Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Kingdom of Saudi Arabia).|School of Textiles, Tianjin Polytechnic University, Key Laboratory of Advanced Textile Composites, Ministry of Education, Tianjin 300387 (P. R. China).
Qiujin
Q
Li
Advanced Nanofabrication and Characterization Core Facilities, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Kingdom of Saudi Arabia).
Yang
Y
Yang
Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Kingdom of Saudi Arabia).
Haneen
H
Omar
Department of Occupational & Environmental Health, Tianjin Medical University, Tianjin 300070 (P. R. China).
Naijun
N
Tang
School of Textiles, Tianjin Polytechnic University, Key Laboratory of Advanced Textile Composites, Ministry of Education, Tianjin 300387 (P. R. China).
Jianfei
J
Zhang
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 (USA).
Zhihong
Z
Nie
Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Kingdom of Saudi Arabia). niveen.khashab@kaust.edu.sa.
Niveen M
NM
Khashab
D000903:Antibiotics, Antineoplastic / Q000737:chemistry; D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D043942:Nanotubes / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D013059:Spectrum Analysis, Raman
D000903:Antibiotics, Antineoplastic; D006046:Gold; D006108:Graphite; D004317:Doxorubicin
chemotherapy; gold nanorods; graphene oxide; photothermal therapy; surface enhanced Raman spectra