Differential Roles of Ventral and Dorsal Streams for Conceptual and Production-Related Components of Tool Use in Acute Stroke Patients.
Impaired tool use despite preserved basic motor functions occurs after stroke in the context of apraxia, a cognitive motor disorder. To elucidate the neuroanatomical underpinnings of different tool use deficits, prospective behavioral assessments of 136 acute left-hemisphere stroke patients were combined with lesion delineation on magnetic resonance imaging (MRI) images for voxel-based lesion-symptom mapping. Deficits affecting both the selection of the appropriate recipient for a given tool (ToolSelect, e.g., choosing the nail for the hammer), and the performance of the typical tool-associated action (ToolUse, e.g., hammering in the nail) were associated with ventro-dorsal stream lesions, particularly within inferior parietal lobule. However, ToolSelect compared with ToolUse deficits were specifically related to damage within ventral stream regions including anterior temporal lobe. Additional retrospective error dichotomization based on the videotaped performances of ToolUse revealed that spatio-temporal errors (movement errors) were mainly caused by inferior parietal damage adjacent to the intraparietal sulcus while content errors, that is, perplexity, unrecognizable, or semantically incorrect movements, resulted from lesions within supramarginal gyrus and superior temporal lobe. In summary, our results suggest that in the use of tools, conceptual and production-related aspects can be differentiated and are implemented in anatomically distinct streams.
Department of Neurology Freiburg Brain Imaging Center BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, Germany.
Markus
M
Martin
Department of Neurology Freiburg Brain Imaging Center BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, Germany.
Lena
L
Beume
Department of Neurology Freiburg Brain Imaging Center.
Dorothee
D
Kümmerer
Department of Neurology Freiburg Brain Imaging Center BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, Germany.
Charlotte S M
CS
Schmidt
Department of Neurology Freiburg Brain Imaging Center.
Tobias
T
Bormann
Department of Neurology Freiburg Brain Imaging Center BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, Germany.
Andrea
A
Dressing
Department of Neurology Freiburg Brain Imaging Center.
Vera M
VM
Ludwig
Department of Neurology Freiburg Brain Imaging Center BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, Germany.
Roza M
RM
Umarova
Department of Neuroradiology, University Medical Center Freiburg, Freiburg im Breisgau, Germany Freiburg Brain Imaging Center.
Irina
I
Mader
Department of Neurology Freiburg Brain Imaging Center.
Michel
M
Rijntjes
Department of Neurology Freiburg Brain Imaging Center BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, Germany.
Christoph P
CP
Kaller
Department of Neurology Freiburg Brain Imaging Center BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, Germany.
Cornelius
C
Weiller
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001072:Apraxias / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D003210:Concept Formation; D005260:Female; D006801:Humans; D033182:Intention; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity; D011597:Psychomotor Performance; D020521:Stroke / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology*
apraxia; dual-loop-model; tool use; ventral stream; voxel-based lesion-symptom mapping