[Investigations into the relationship between respiratory disorders and excessive body weight in the adolescents presenting with bronchial asthma treated based at a specialized health resort facility].
A total of 71 patients with bronchial asthma (BA) were examined and treated based at a specialized health facility of whom 43 ones presented with mild asthma and 26 patients with moderately severe asthma in remission. The median age of the patients was 12,04 ± 2,08 years. Spirometry parameters: MOS50, MOS75, and PSV, proved to be of high informative value combined with high enough sensitivity and specificity. The significant difference between the groups as a whole (p < 0.05) were documented based on the serum leptin levels that were higher in the overweight patients and especially in the girls (p < 0.05). The leptin level was a similarly sensitive/specific (AUROC > 0.5) and informative (SCDFC > 0.5) parameter which confirms its diagnostic value given it is employed in combination with overweight for the evaluation of the status of the patients suffering from asthma. Negative linear and non-parametric correlation between the functional parameters and the serum leptin levels in the overweight patients with bronchial asthma suggests that the enhanced leptin concentration may serve as a marker of strong obstruction and severe inflammation at all levels of the respiratory tract in the patients presenting with a combination of the two conditions.
GBOU VPO "Samarskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii; GBUZ "Samarskiĭ oblastnoĭ detskiĭ sanatoriĭ "Iunost'".
N A
NA
Mokina
GBOU VPO "Samarskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii.
A V
AV
Iashkov
GBUZ "Samarskiĭ oblastnoĭ detskiĭ sanatoriĭ "Iunost'".
M A
MA
Gudkova
GBUZ "Samarskiĭ oblastnoĭ detskiĭ sanatoriĭ "Iunost'".
E N
EN
Samoĭlova
GBUZ Samarskoĭ oblasti "Koshkinskaia TsRB".
Iu A
IA
Goriainov
D000293:Adolescent; D001249:Asthma / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D002648:Child; D005260:Female; D006294:Health Resorts; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D050177:Overweight / Q000150:complications* / Q000453:epidemiology; D012119:Respiration
D020738:Leptin