POPsicle for Fever! Cooling Down the Inflammasome.
Inhibition of the inflammasome might be beneficial for numerous inflammatory pathologies. In this issue of Immunity, de Almeida et al. (2015) report that the PYRIN domain-only protein (POP1) efficiently inhibits inflammasome activation, identifying it as a pan-inflammasome inhibitor.
Departments of Biomedical Sciences and Pediatrics, Divisions of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Kenichi
K
Shimada
Departments of Biomedical Sciences and Pediatrics, Divisions of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Timothy R
TR
Crother
Departments of Biomedical Sciences and Pediatrics, Divisions of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: moshe.arditi@cshs.org.
Moshe
M
Arditi
D000818:Animals; D056587:Cryopyrin-Associated Periodic Syndromes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D010538:Peritonitis / Q000276:immunology*; D012261:Ribonucleoproteins / Q000378:metabolism*
D058847:Inflammasomes; D012261:Ribonucleoproteins