Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes.
Acemannan has been previously reported as a direct pulp-capping agent in animal study. This natural material demonstrated its biocompatibility and enhanced reparative dentin formation. The objective of this study was to investigate the action of acemannan as a direct pulp-capping material in human primary teeth with deep caries. Forty-two deeply carious mandibular primary molars from 37 children, aged 7-11 years old diagnosed with reversible pulpitis were studied. After completely removing the infected dentine, teeth with a pinpoint pulpal exposure were randomly divided into two treatment groups: acemannan or calcium hydroxide. A glass-ionomer cement base was applied to all teeth prior to restoration with stainless steel crowns. Clinical and radiographic evaluation was performed 6 months post-treatment. The teeth due to exfoliate were extracted and histopathologically evaluated for inflammation, dentine bridge formation, and soft tissue organization. At 6 months, the overall clinical and radiographic success rates of direct pulp capping with acemannan and calcium hydroxide at 6 months were 72.73 and 70.0 %, respectively. The histopathological results indicated that the acemannan-treated group had significantly better histopathological responses compared with the calcium hydroxide-treated group (p < 0.05). These data suggest acemannan offers a valuable alternative biomaterial for vital pulp therapy in primary teeth.
Dental Biomaterials Science Program, Graduate School, Chulalongkorn University, Bangkok, Thailand.|Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Siriporn
S
Songsiripradubboon
Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Wijit
W
Banlunara
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Polkit
P
Sangvanich
Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Chutima
C
Trairatvorakul
Research Unit of Herbal Medicine, Biomaterial, and Material for Dental Treatment, Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Henri-Dunant Rd, Patumwan, Bangkok, 10330, Thailand. pthunyak@yahoo.com.
Pasutha
P
Thunyakitpisal
D002126:Calcium Hydroxide / Q000627:therapeutic use; D002648:Child; D003782:Dental Pulp / Q000187:drug effects; D003785:Dental Pulp Capping / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008351:Mannans / Q000627:therapeutic use*; D008963:Molar; D010936:Plant Extracts / Q000627:therapeutic use*; D011671:Pulpitis / Q000188:drug therapy*; D014094:Tooth, Deciduous; D016896:Treatment Outcome
D008351:Mannans; D010936:Plant Extracts; D002126:Calcium Hydroxide; C058414:acemannan
Acemannan; Aloe vera; Biomaterial; Clinical study; Histopathological evaluation; Vital pulp therapy