Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis.
Primary resistance to tyrosine-kinase inhibitors (TKIs) is quite uncommon in chronic-phase Chronic Myeloid Leukemia (CML) and related to still poorly understood mechanisms, as ABL mutations are rarely detected in primary resistant patients. We report the challenging case of a CML patient who was resistant to multiple TKIs because of different emerging ABL mutations and became pregnant while on Nilotinib therapy despite repeated and clear discouragement to conceive. She decided to continue with her pregnancy, showing an admirable and incredible perseverance in the pursuit of her personal aims.
Department of Onco-Hematology, Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100 Pavia, Italy.
Ester M
EM
Orlandi
Department of Onco-Hematology, Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100 Pavia, Italy ; Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
Chiara
C
Elena
Department of Onco-Hematology, Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100 Pavia, Italy.
Silvia
S
Zibellini
Chronic Myeloid Leukemia; Pregnancy; Resistance; Tyrosine-kinase inhibitors