Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis.
OBJECTIVE
To examine the association between circulating 25-hydroxyvitamin D [25(OH)D] levels and colorectal adenoma in a case-control study and a meta-analysis.


METHODS
We conducted a matched case-control study (112 cases and 112 matched controls) and combined 15 studies, including our study, in a meta-analysis. The study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a random-effects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis.


RESULTS
In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH)D levels and colorectal adenoma (OR = 0.68; 95%CI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location (proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs (95%CIs) were 0.70 (0.52-0.88) in the US and 0.66 (0.34-0.97) in Asia.


CONCLUSIONS
These data suggest an inverse association between circulating 25(OH)D levels and colorectal adenoma in both Western and Asian populations.
Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
Yoon Ji
YJ
Choi
Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
Young Ha
YH
Kim
Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
Chang Ho
CH
Cho
Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
Sung Hi
SH
Kim
Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
Jung Eun
JE
Lee
D000236:Adenoma / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D000368:Aged; D001317:Austria / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology
D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
25-hydroxyvitamin D levels; Cancer prevention; Colorectal adenoma