Duodenal adenoma surveillance in patients with familial adenomatous polyposis.
Familial adenomatous polyposis (FAP) is a hereditary disorder caused by Adenomatous Polyposis Gene mutations that lead to the development of colorectal polyps with great malignant risk throughout life. Moreover, numerous extracolonic manifestations incorporate different clinical features to produce varied individual phenotypes. Among them, the occurrence of duodenal adenomatous polyps is considered an almost inevitable event, and their incidence rates increase as a patient's age advances. Although the majority of patients exhibit different grades of duodenal adenomatosis as they age, only a small proportion (1%-5%) of patients will ultimately develop duodenal carcinoma. Within this context, the aim of the present study was to review the data regarding the epidemiology, classification, genetic features, endoscopic features, carcinogenesis, surveillance and management of duodenal polyps in patients with FAP.
Fábio Guilherme Campos, Adriana Vaz Safatle-Ribeiro, Gastroenterology Department, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, PC 01411-000, Brazil.
Fábio Guilherme
FG
Campos
Fábio Guilherme Campos, Adriana Vaz Safatle-Ribeiro, Gastroenterology Department, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, PC 01411-000, Brazil.
Marianny
M
Sulbaran
Fábio Guilherme Campos, Adriana Vaz Safatle-Ribeiro, Gastroenterology Department, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, PC 01411-000, Brazil.
Adriana Vaz
AV
Safatle-Ribeiro
Fábio Guilherme Campos, Adriana Vaz Safatle-Ribeiro, Gastroenterology Department, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, PC 01411-000, Brazil.
Carlos Augusto Real
CA
Martinez
Adenoma; Digestive system; Duodenum; Endoscopy; Familial adenomatous polyposis; Surveillance