Evaluation of the 2008 World Health Organization classification for non-mycosis fungoides, non-Sezary syndrome T/NK-cell lymphomas with primary cutaneous involvement.
BACKGROUND
Cutaneous non-mycosis fungoides non-Sezary syndrome T/NK cell lymphomas (non-MF/non-SS CTCL) are rare. In 2005, a consensus of the World Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classifications for primary cutaneous lymphomas was established. These guidelines were then adopted into the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 2008. This study aims to assess the applicability of the WHO 2008 classification in a retrospective series of CTCL cases registered in a reference academic center in Brazil.


METHODS
Twenty-seven patients with non-MF/non-SS CTCL were studied. Clinical, histopathological and immunophenotypical features based on an extensive panel of antibodies were applied to classify the cases according to the WHO, 2008.


RESULTS
Overall, diagnostic categories included eight (29.6%) cutaneous anaplastic large-cell lymphoma, five (18.5%) lymphomatoid papulosis, six (22.2%) extranodal natural killer (NK)/T-cell lymphoma, nasal type, five (18.5%) adult T-cell leukemia/lymphoma, one (3.7%) cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma and two (7.4%) of peripheral T-cell lymphoma not otherwise specified (NOS).


CONCLUSIONS
The WHO classification (2008) was applicable to most cases of non-MF/non-SS CTCL, while some cases remained unclassified and were considered NOS-peripheral T-cell lymphoma. An unexpected high frequency of NK/T-cell lymphoma nasal type was observed.
Pathology Laboratory, Fleury Medicine and Health, Sao Paulo, Brazil.|Department of Dermatology, University of São Paulo Medical School, Sao Paulo, Brazil.
Daniel
D
Chang
Department of Pathology, University of São Paulo Medical School, Sao Paulo, Brazil.
Maria Cláudia Nogueira
MCN
Zerbini
Department of Dermatology, University of São Paulo Medical School, Sao Paulo, Brazil.
Mirian Nacagami
MN
Sotto
Department of Pathology, University of São Paulo Medical School, Sao Paulo, Brazil.
Sheila Aparecida Coelho
SAC
Siqueira
Department of Dermatology, University of São Paulo Medical School, Sao Paulo, Brazil.
José Antonio
JA
Sanches
WHO classification; cutaneous T-cell lymphoma; dermatopathology; histopathology; immunocytochemistry