Diterpene Constituents of Euphorbia exigua L. and Multidrug Resistance Reversing Activity of the Isolated Diterpenes.
Phytochemical investigation of the MeOH extract obtained from the aerial parts of the annual weed Euphorbia exigua L. resulted in the isolation of two novel (1, 2) and one known (3) jatrophane diterpenes. Their structures were established by extensive 1D- and 2D-NMR spectroscopy and HR-ESI-MS. The isolated compounds were evaluated for multidrug resistance (MDR) reversing activity on human MDR gene-transfected L5178 mouse lymphoma cells; and all three compounds were found to modulate the intracellular drug accumulation.
Department of Pharmacognosy, University of Szeged, Eötvös u. 6, HU-6720 Szeged, (phone: +36 62 546451, fax: +36 62 545704). redei@pharm.u-szeged.hu.
Dóra
D
Rédei
Department of Pharmacognosy, University of Szeged, Eötvös u. 6, HU-6720 Szeged, (phone: +36 62 546451, fax: +36 62 545704).
Klára
K
Boros
Department of Pharmacognosy, University of Szeged, Eötvös u. 6, HU-6720 Szeged, (phone: +36 62 546451, fax: +36 62 545704).
Peter
P
Forgo
Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, HU-6720 Szeged.
Joseph
J
Molnár
Department of Medical Chemistry, University of Szeged, Dóm tér 8, HU-6720 Szeged.
Zoltán
Z
Kele
Department of Organic Chemistry, University of Szeged, Dóm tér 8, HU-6720 Szeged.
István
I
Pálinkó
Department of Botany, Faculty of Agricultural and Food Sciences, University of West Hungary, Lucsony u. 15 - 17, HU-9200 Mosonmagyaróvár.
Gyula
G
Pinke
Department of Pharmacognosy, University of Szeged, Eötvös u. 6, HU-6720 Szeged, (phone: +36 62 546451, fax: +36 62 545704).
Judit
J
Hohmann
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D051379:Mice; D014162:Transfection
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004224:Diterpenes; C530345:jatrophane
Diterpene; Euphorbia exigua; Jatrophane; Multidrug resistance; P-Glycoprotein