The interface makes a difference: lanthanide ion coated vesicles hydrolyze phosphodiesters.
Lanthanide ions are strong Lewis acids. Their complexation to a variety of ligands can further enhance their Lewis acidity allowing the hydrolysis of phosphoesters and even DNA. We show that the interaction of lanthanide ions with vesicles from zwitterionic phosphatidylcholine lipids gives supramolecular structures in which the metal ion is loosely coordinated to the surface. This assembly provides a high density of Lewis-acidic metal centres, which hydrolyze phosphodiesters with enhanced rates.
Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany. burkhard.koenig@ur.de.
Michal
M
Poznik
Uday
U
Maitra
Burkhard
B
König
D018699:Coated Vesicles / Q000737:chemistry*; D006868:Hydrolysis; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008563:Membrane Lipids / Q000737:chemistry*; D008958:Models, Molecular; D010713:Phosphatidylcholines / Q000737:chemistry*
D028581:Lanthanoid Series Elements; D008563:Membrane Lipids; D010713:Phosphatidylcholines; C017251:1,2-oleoylphosphatidylcholine