pH-Responsive supramolecular vesicles assembled by water-soluble pillar[5]arene and a BODIPY photosensitizer for chemo-photodynamic dual therapy.
Supramolecular vesicles which can successfully encapsulate DOX and exhibit rapid drug release in a low-pH environment are constructed based on the host-guest interaction of water-soluble pillar[5]arene and a BODIPY derivative. They show remarkable combination of chemo- and photodynamic activities, suggesting a promising drug nanocarrier.
Key Laboratory of Mesoscopic Chemistry of MOE and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. lywang@nju.edu.cn huxy@nju.edu.cn.
Lu-Bo
LB
Meng
Wenyi
W
Zhang
Dongqi
D
Li
Yan
Y
Li
Xiao-Yu
XY
Hu
Leyong
L
Wang
Guigen
G
Li
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001896:Boron Compounds / Q000737:chemistry*; D047250:Calixarenes; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000903:Antibiotics, Antineoplastic; D001896:Boron Compounds; D003692:Delayed-Action Preparations; D017319:Photosensitizing Agents; D000644:Quaternary Ammonium Compounds; C570642:pillar(5)arene; D014867:Water; D047250:Calixarenes; D004317:Doxorubicin