[Multidrug-resistant tuberculosis: challenges of a global emergence].
Drug-resistant tuberculosis, in particular Multi-Drug Resistant (MDR-TB) is an increasing global concern and a major burden for some developing countries, especially the BRICS. It is assumed that every year roughly 350 000 new MDR-TB cases occur in the world, on average in 20.5% of TB patients that have been previously treated but also in 3.5% of persons that have never been on TB treatment before. The global distribution of cases is very heterogeneous and is now better understood thanks to a growing number of specific surveys and routine surveillance systems: incidence is much higher in southern Africa and in all countries formerly part of the USSR. Countries with weak health systems and previously inefficient TB control programs are highly vulnerable to MDR epidemics because program failures do help creating, maintaining and spreading resistances. Global response is slowly rolled out and diagnosis capacities are on the rise (mostly with genotypic methods) but adequate and successful treatment and care is still limited to a minority of global cases. From a public health perspective the MDR-TB growing epidemics will not be controlled merely by the introduction of few new antibiotics because it is also linked to patient's compliance and adequate case management supported by efficient TB program. In depth quality improvement will only be achieved after previous errors are thoroughly analyzed and boldly corrected.
Direction générale de la santé, Ministère de la santé des affaires sociales et des droits des femmes, 14, avenue Duquesne, 75007, Paris, France. Thierry.COMOLET@sante.gouv.fr.
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D000995:Antitubercular Agents / Q000627:therapeutic use; D021821:Communicable Diseases, Emerging / Q000188:drug therapy / Q000453:epidemiology*; D003906:Developing Countries / Q000706:statistics & numerical data; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D058872:Epidemics; D014943:Global Health; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology*
D000995:Antitubercular Agents
Developing countries; Drug resistance; MDR-TB; TB control; Tuberculosis; XDR