Lower neuronal variability in the monkey dorsolateral prefrontal than posterior parietal cortex.
The dorsolateral prefrontal and posterior parietal cortex are two brain areas involved in cognitive functions such as spatial attention and working memory. When tested with identical tasks, only subtle differences in firing rate are present between neurons recorded in the two areas. In this article we report that major differences in neuronal variability characterize the two areas during working memory. The Fano factors of spike counts in dorsolateral prefrontal neurons were consistently lower than those of the posterior parietal cortex across a range of tasks, epochs, and conditions in the same monkeys. Variability differences were observed despite minor differences in firing rates between the two areas in the tasks tested and higher overall firing rate in the prefrontal than in the posterior parietal sample. Other measures of neuronal discharge variability, such as the coefficient of variation of the interspike interval, displayed the same pattern of lower prefrontal variability. Fano factor values were negatively correlated with performance in the working memory task, suggesting that higher neuronal variability was associated with diminished task performance. The results indicate that information involving remembered stimuli is more reliably represented in the prefrontal than the posterior parietal cortex based on the variability of neuronal responses, and suggest functional differentiation between the two areas beyond differences in firing rate.
Department of Neurobiology & Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Xue-Lian
XL
Qi
Department of Neurobiology & Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina cconstan@wakehealth.edu.
Christos
C
Constantinidis
D000200:Action Potentials; D000818:Animals; D003627:Data Interpretation, Statistical; D005133:Eye Movements / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D014796:Visual Perception / Q000502:physiology
Fano factor; intraparietal sulcus; monkey; principal sulcus; working memory