[Incidence of skin and non-skin cancers in Afro-Caribbean renal transplant recipients: Guadeloupe data from 2004 to 2011].
BACKGROUND
Cancer is the main complication of transplantation surgery. The literature concerning renal transplant recipients among the Afro-Caribbean population is scant. The aim of this study was to determine the incidence of cancer in these patients, with the secondary objective being to identify predisposing factors for cancer.


METHODS
This was an epidemiological and retrospective study that included all Guadeloupians of phototype V-VI undergoing renal transplantation from 01/01/2004 to 31/12/2011. Skin cancer screening was performed before transplantation and during an annual dermatological consultation following transplantation. Screening for non-cutaneous cancers was guided by clinical symptoms or by the results of the screening examinations recommended in the current guidelines. At the study time-point (31/12/2011), all patients were examined by a dermatologist.


RESULTS
One hundred and two patients were included : 42 women and 60 men (mean age: 52.1±11.6 years at transplantation). Eight cancers were diagnosed. The cumulative incidence of cancer was 7.8% at 3 years. Three factors were associated with more rapid onset of cancer: personal history or familial history of cancer, and genital lesion induced by HPV.


CONCLUSIONS
Our results suggest a low incidence of cancer in Afro-Caribbean renal transplant patients. Personal or family history of cancer and HPV-induced genital lesions would appear to accelerate the onset of cancer in this population.
Service de dermatologie, hôpital Morvan, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France.
M
M
Ameline
UF dermatologie-médecine interne, centre hospitalier universitaire de Pointe-à-Pitre, route de Chauvel, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe.
L
L
Bonnecarrere
Centre d'investigation clinique Antilles Guyane, Inserm/DGOS CIC 1424, CHU de Pointe-à-Pitre, route de Chauvel, 97159 Pointe-à-Pitre cedex, Guadeloupe.
B
B
Tressières
Service de néphrologie, clinique de Choisy, D119, 97190 Le Gosier, Guadeloupe.
K
K
Hue
Unité de transplantation rénale, CHU de Pointe-à-Pitre, route de Chauvel, 97159 Pointe-à-Pitre cedex, Guadeloupe.
J
J
Claudeon
Inserm U 1085, service d'urologie, CHU de Pointe-à-Pitre, université Antilles Guyane, route de Chauvel, 97159 Pointe-à-Pitre cedex, Guadeloupe.
P
P
Blanchet
Laboratoire d'hématologie-immunologie-histocompatibilité, CHU de Pointe-à-Pitre, route de Chauvel, 97159 Pointe-à-Pitre cedex, Guadeloupe.
R
R
Chout
Laboratoire d'hygiène et de santé publique, hôpital Morvan, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France.
P
P
Saliou
EA 4546, UF de dermatologie-médecine interne, centre hospitalier universitaire de Pointe-à-Pitre, université Antilles-Guyane, route de Chauvel, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe. Electronic address: nadege.cordel@chu-guadeloupe.fr.
N
N
Cordel
D000328:Adult; D000349:Africa / Q000208:ethnology; D017691:Caribbean Region / Q000208:ethnology; D005260:Female; D019430:Guadeloupe / Q000453:epidemiology; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000208:ethnology* / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000208:ethnology; D009386:Neoplastic Syndromes, Hereditary / Q000208:ethnology; D030361:Papillomavirus Infections / Q000208:ethnology; D011183:Postoperative Complications / Q000208:ethnology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000208:ethnology* / Q000209:etiology; D013472:Sunlight / Q000009:adverse effects; D014412:Tumor Virus Infections / Q000208:ethnology
D007166:Immunosuppressive Agents
Afro-Caribbean; Afro-Caribéens; Antilles; Cancer; Skin phototype; Transplantation; West Indies