Associations among depression, suicidal behavior, and quality of life in patients with human immunodeficiency virus.
OBJECTIVE
To investigate the potential associations among major depression, quality of life, and suicidal behavior in human immunodeficiency virus (HIV) patients.


METHODS
A detailed MEDLINE search was carried out to identify all articles and book chapters in English published from January 1995 to January 2015.


RESULTS
Based on the main findings, the prevalence of major depressive disorder (MDD) ranged from 14.0% to 27.2%. Furthermore, the prevalence of suicidal ideation varied from 13.6% to 31.0% whereas, attempted suicides were reported to range from 3.9% to 32.7%. Interestingly, various associated risk factors for both depression and suicide were identified in HIV patients. Finally, consistent associations were reported among MDD, suicidal ideation, and poor quality of life in individuals living with HIV.


CONCLUSIONS
Although additional studies are needed to elucidate this complex association, our results suggest the importance of early detection of both MDD and suicidality in patients living with HIV.
Gianluca Serafini, Mario Amore, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Gianluca
G
Serafini
Gianluca Serafini, Mario Amore, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Franco
F
Montebovi
Gianluca Serafini, Mario Amore, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Dorian A
DA
Lamis
Gianluca Serafini, Mario Amore, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Denise
D
Erbuto
Gianluca Serafini, Mario Amore, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Paolo
P
Girardi
Gianluca Serafini, Mario Amore, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Mario
M
Amore
Gianluca Serafini, Mario Amore, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Maurizio
M
Pompili
Human immunodeficiency virus infection; Major depression; Quality of life; Suicidal behavior