Delayed healing of lower limb fractures with bisphosphonate therapy.
BACKGROUND
Bisphosphonate therapy (BT) is used commonly in the management of osteoporosis. A systematic review was conducted investigating delayed union of lower limb, long bone fractures in patients on BT. We specifically assessed whether BT increases the risk of delayed union or non-union in lower limb, long bone fractures.


METHODS
A literature search was conducted in the PubMed and Embase™ on 4 November 2014. Articles that investigated lower limb fractures, history of BT and fracture union were included in the review.


RESULTS
A total of 9,809 papers were retrieved and 14 were deemed suitable for this review. The mean time to union in patients on BT was 8.5 months. A longer time to union was reported in a study investigating BT users versus controls (6.5 vs 4.8 months respectively). The mean rate of delayed or non-union for BT associated atypical fractures was 20% per fracture. Specifically in one study, delayed union was more common in the cohort with more than three years of BT (67%) than in the group with less than three years of BT (26%). Surgical fixation was associated with improved outcomes compared with non-operative management.


CONCLUSIONS
BT has been described to be associated with multiple adverse outcomes related to atypical fractures. Current evidence recommends operative management for this patient group. Further investigation is required to evaluate the exact effects of BT on lower limb fractures, in particular typical femoral fractures.
Royal Melbourne Hospital , Australia.
B
B
Yue
Royal Melbourne Hospital , Australia.
A
A
Ng
University of Melbourne , Australia.
H
H
Tang
Royal Melbourne Hospital , Australia.
S
S
Joseph
University of Melbourne , Australia.
M
M
Richardson
D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D005264:Femoral Fractures / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D017102:Fracture Healing / Q000187:drug effects*; D005599:Fractures, Ununited; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy
D050071:Bone Density Conservation Agents; D004164:Diphosphonates
Bisphosphonate; Bone suppression; Delayed union; Non-union