(210)Po microsphere radiological design for tumor vascular disruption.
The feasibility of disrupting a tumor's vascular structure using (210)Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for (210)Po alpha particles are sufficient to disrupt a tumor's arteriole structure while minimizing the dose outside the blood vessel wall. (210)Po photons contribute minimal dose to healthy tissue. The requisite activity of (210)Po to facilitate vascular disruption is calculated.
Bevelacqua Resources , Richland, WA , USA.
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Bevelacqua
Absorbed dose; Dose assessment; Microspheres; Radiation therapy; Tumor vascular disruption