Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics.
We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.
The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.
Erez Lieberman
EL
Aiden
Genomics and Immunity, NIAMS and NCI, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: rafael.casellas@nih.gov.
Rafael
R
Casellas
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D000076246:CCCTC-Binding Factor; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D008213:Lymphocyte Activation; D012097:Repressor Proteins / Q000378:metabolism; D060152:V(D)J Recombination
D000076246:CCCTC-Binding Factor; C000619697:CTCF protein, human; D012097:Repressor Proteins