Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.
BMS-641988 (23) is a novel, nonsteroidal androgen receptor antagonist designed for the treatment of prostate cancer. The compound has high binding affinity for the AR and acts as a functional antagonist in vitro. BMS-641988 is efficacious in multiple human prostate cancer xenograft models, including CWR22-BMSLD1 where it displays superior efficacy relative to bicalutamide. Based on its promising preclinical profile, BMS-641988 was selected for clinical development.
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Aaron
A
Balog
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Richard
R
Rampulla
Albany Molecular Research Inc. , 21 Corporate Circle, Albany, New York 12203, United States.
Gregory S
GS
Martin
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Stanley R
SR
Krystek
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Ricardo
R
Attar
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Janet
J
Dell-John
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
John D
JD
DiMarco
Albany Molecular Research Inc. , 21 Corporate Circle, Albany, New York 12203, United States.
David
D
Fairfax
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Jack
J
Gougoutas
Albany Molecular Research Inc. , 21 Corporate Circle, Albany, New York 12203, United States.
Christian L
CL
Holst
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Andrew
A
Nation
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Cheryl
C
Rizzo
Albany Molecular Research Inc. , 21 Corporate Circle, Albany, New York 12203, United States.
Lana M
LM
Rossiter
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Liang
L
Schweizer
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Weifang
W
Shan
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Steven
S
Spergel
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Thomas
T
Spires
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Georgia
G
Cornelius
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Marco
M
Gottardis
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
George
G
Trainor
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Gregory D
GD
Vite
Bristol Myers-Squibb Research and Development , Princeton, New Jersey 08543, United States.
Mark E
ME
Salvati
BMS-641988; CRPC; Prostate cancer; androgen receptor