Nanoparticle-Loaded Protein-Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery.
A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.
Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK.
Jeong Yu
JY
Lee
Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK.
Dario
D
Carugo
Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK.
Calum
C
Crake
Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK.
Joshua
J
Owen
Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK.
Marie
M
de Saint Victor
Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK.
Anjali
A
Seth
Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK.
Constantin
C
Coussios
Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK.
Eleanor
E
Stride
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D004867:Equipment Design; D005290:Ferric Compounds / Q000737:chemistry; D005466:Fluorocarbons / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000737:chemistry; D019301:Oleic Acid / Q000737:chemistry; D017239:Paclitaxel / Q000008:administration & dosage / Q000493:pharmacokinetics; D011092:Polyethylene Glycols / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012709:Serum Albumin / Q000737:chemistry; D014463:Ultrasonography / Q000379:methods*
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D005290:Ferric Compounds; D005466:Fluorocarbons; D058185:Magnetite Nanoparticles; D000644:Quaternary Ammonium Compounds; D012709:Serum Albumin; C000499:ferric oxide; D019301:Oleic Acid; D011092:Polyethylene Glycols; C022806:dodecyltrimethylammonium; D017239:Paclitaxel
breast cancer; chemotherapy; microbubbles; nanodroplets; ultrasound