Review of laboratory-based terrestrial bioaccumulation assessment approaches for organic chemicals: Current status and future possibilities.
In the last decade, interest has been renewed in approaches for the assessment of the bioaccumulation potential of chemicals, principally driven by the need to evaluate large numbers of chemicals as part of new chemical legislation, while reducing vertebrate test organism use called for in animal welfare legislation. This renewed interest has inspired research activities and advances in bioaccumulation science for neutral organic chemicals in aquatic environments. In January 2013, ILSI Health and Environmental Sciences Institute convened experts to identify the state of the science and existing shortcomings in terrestrial bioaccumulation assessment of neutral organic chemicals. Potential modifications to existing laboratory methods were identified, including areas in which new laboratory approaches or test methods could be developed to address terrestrial bioaccumulation. The utility of "non-ecotoxicity" data (e.g., mammalian laboratory data) was also discussed. The highlights of the workshop discussions are presented along with potential modifications in laboratory approaches and new test guidelines that could be used for assessing the bioaccumulation of chemicals in terrestrial organisms.
DuPont, Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA.
Robert
R
Hoke
University of North Texas, Denton, Texas, USA.
Duane
D
Huggett
US Army Engineer Research and Development Center, Vicksburg, Mississippi.
Sandra
S
Brasfield
AstraZeneca, Global Environment, Cheshire, United Kingdom; Present address: WCA, Brunel House, Volunteer Way, Faringdon, Oxfordshire, United Kingdom.
Becky
B
Brown
ILSI-HESI, Washington, DC, USA.
Michelle
M
Embry
Exponent, Bellevue, Washington, USA.
Anne
A
Fairbrother
PMRA, Health Canada, Ottawa, Ontario, Canada.
Michelle
M
Kivi
ExxonMobil Biomedical Sciences, Machelen, Belgium.
Miriam Leon
ML
Paumen
Univ Guelph, Guelph, Ontario, Canada.
Ryan
R
Prosser
RIFM, Woodcliff Lake, New Jersey, USA.
Dan
D
Salvito
Environment Canada, Ottawa, Ontario, Canada.
Rick
R
Scroggins
D000818:Animals; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis* / Q000633:toxicity; D020387:Food Chain; D006801:Humans; D007753:Laboratories; D009930:Organic Chemicals / Q000032:analysis* / Q000633:toxicity; D018570:Risk Assessment / Q000379:methods
D004785:Environmental Pollutants; D009930:Organic Chemicals
Bioaccumulation assessment; Chemical regulation; POPs; Terrestrial; Wildlife