Advances in Vascular Hyporeactivity After Shock: The Mechanisms and Managements.
Vascular reactivity to vasoconstrictors and vasodilators is greatly reduced after severe trauma, shock, and sepsis or multiple organ dysfunction syndrome. This reduced vascular reactivity severely interferes with the treatment of shock and other critical conditions. In particular, it interferes with the efficacy of vasoactive agents. Consequently, it is very important to elucidate the mechanisms and search for the effective treatment measures. In recent years, a lot of studies focused on the characteristics and the change rules of vascular hyporeactivity and mechanisms following shock. Also, the treatment approaches based on various mechanisms have been a hot pot these years.
State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, P.R. China.
Chenyang
C
Duan
Guangming
G
Yang
Tao
T
Li
Liangming
L
Liu
D000138:Acidosis; D000328:Adult; D000367:Age Factors; D000368:Aged; D000701:Analgesics, Opioid / Q000737:chemistry; D001808:Blood Vessels / Q000187:drug effects / Q000503:physiopathology*; D002056:Burns / Q000628:therapy; D002118:Calcium / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism; D016638:Critical Illness; D016232:Endothelins / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011493:Protein Kinase C / Q000737:chemistry; D012737:Sex Factors; D012771:Shock, Hemorrhagic / Q000503:physiopathology* / Q000628:therapy*; D012772:Shock, Septic / Q000628:therapy; D013755:Tetradecanoylphorbol Acetate / Q000737:chemistry; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*; D054460:rho-Associated Kinases / Q000378:metabolism
D000701:Analgesics, Opioid; D016232:Endothelins; D010455:Peptides; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009569:Nitric Oxide; D002248:Carbon Monoxide; D054460:rho-Associated Kinases; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium