Preventive effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD)-like behavior in male C57/B6 mice.
We investigated the preventive effects of Rg1 on a model of mouse post-traumatic stress disorder (PTSD) induced by electric shock combined with situation reminder and explored the underlying mechanism. In the experiment, before the PTSD animal model was developed, Rg1 (10, 5, and 2.5mg/kg) was orally administered for one week. After the animal model was established, PTSD-like behavior was observed using elevated plus maze, black and light box, and open field tests. One hour after the behavior test, all mice were sacrificed, and then serum corticosterone (CORT) and hypothalamus corticotrophin-releasing hormone (CRH) assays were performed. Results showed that Rg1 (5mg/kg) treatments relieved PTSD-like behavior by altering elevated serum corticosterone and hypothalamus CRH levels. By contrast, fluoxetine (3mg/kg) treatment reversed the behavior changes and had no effect on increased CORT and CRH levels. These findings confirmed the preventive effect of Rg1 in PTSD model. Decreasing CORT and CRH levels may be one of the underlying mechanisms.
Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhongli
Z
Wang
Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Kexuan
K
Zhu
Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Lin
L
Chen
Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Liufeng
L
Ou Yang
Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Yufang
Y
Huang
Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: zhaoyunan-js@163.com.
Yunan
Y
Zhao
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D005473:Fluoxetine / Q000494:pharmacology; D036145:Ginsenosides / Q000494:pharmacology / Q000627:therapeutic use*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology
D000928:Antidepressive Agents; D036145:Ginsenosides; D018696:Neuroprotective Agents; D005473:Fluoxetine; D003346:Corticotropin-Releasing Hormone; C035054:ginsenoside Rg1; D003345:Corticosterone
Corticosterone; Corticotrophin-releasing hormone; Ginsenoside Rg1; Post-traumatic stress disorder; Traditional Chinese medicine