Palladium-Catalyzed Desulfitative Oxidative Coupling between Arenesulfinic Acid Salts and Allylic Alcohols: A Strategy for the Selective Construction of β-Aryl Ketones and Aldehydes.
An efficient palladium-catalyzed desulfitative oxidative coupling of sodium arylsulfinites for highly region-selective Heck-type reaction of allylic alcohols has been developed. The compatibility of the functionalities of -I, -Br, and -F would explore further postfunctionalization of the C-X bonds. This method provides a new and straightforward protocol for the synthesis of β-aryl ketones and aldehydes. The deuterium labeling experiments indicated that this transformation may proceed via a [1, 2-H] shift process.
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, China.|School of Pharmaceutical Sciences, Gannan Medical University , Ganzhou, Jiangxi 341000, China.
Jianhua
J
Liao
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, China.
Zhenming
Z
Zhang
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, China.
Xiaodong
X
Tang
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, China.
Wanqing
W
Wu
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, China.
Wei
W
Guo
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, China.
Huanfeng
H
Jiang