Arterial spin-labeling MR imaging of cerebral hemorrhages.
BACKGROUND
The purpose of this study is to identify the characteristics of brain perfusion measured by arterial spin-labeling magnetic resonance imaging (ASL-MRI) in cerebral hemorrhages.


METHODS
Brain blood flow values (CBF-ASL values) for cerebral and cerebellar hemispheres and segmented cerebral regions were measured by ASL-MRI in 19 putaminal hemorrhage patients and 20 thalamic hemorrhage patients in acute or subacute stages. We assessed the lateralities of CBF-ASL values and the relationships between CBF-ASL values and other imaging findings and clinical manifestations.


RESULTS
Both the 19 putaminal hemorrhage patients and the 20 thalamic hemorrhage patients had significantly low CBF-ASL values of the contralateral cerebellum in subacute stage, suggesting that ASL-MRI might delineate crossed cerebellar diaschisis (CCD). Ipsilateral low CBF-ASL values were observed in frontal lobes and thalami with a putaminal hemorrhage and lentiform nuclei, temporal lobes, and parietal lobes with a thalamic hemorrhage, suggesting that ASL-MRI showed the ipsilateral cerebral diaschisis (ICD). In the putaminal hemorrhage patients, the hematoma volume negatively affected both the bilateral cerebellar and cerebral hemispheric CBF-ASL values. In the thalamic hemorrhage patients, a concomitant intraventricular hemorrhage caused low cerebral hemispheric CBF-ASL values.


CONCLUSIONS
The use of ASL-MRI is sensitive to the perfusion abnormalities and could thus be helpful to estimate functional abnormalities in cerebral hemorrhage patients.
Department of Radiology, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. tnogucci@radiol.med.kyushu-u.ac.jp.|Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan. tnogucci@radiol.med.kyushu-u.ac.jp.
Tomoyuki
T
Noguchi
Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan.
Masashi
M
Nishihara
Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan.
Yoshiaki
Y
Egashira
Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan.
Shinya
S
Azama
Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan.
Tetsuyoshi
T
Hirai
Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan.
Isao
I
Kitano
Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan.
Yusuke
Y
Yakushiji
Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan.
Masatou
M
Kawashima
Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, Saga, Japan.
Hiroyuki
H
Irie
D000368:Aged; D001783:Blood Flow Velocity; D001810:Blood Volume; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000473:pathology / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000517:prevention & control*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
D013113:Spin Labels
Arterial spin-labeling; Brain perfusion; Cerebral hemorrhage; Putaminal hemorrhage; Thalamic hemorrhage