Association of Vitamin D Receptor Cdx-2 Polymorphism With Cancer Risk: A Meta-Analysis.
Vitamin D receptor (VDR) Cdx-2 polymorphism (rs11568820) has been indicated to be associated to cancer susceptibility. However, published studies reported mixed results. This meta-analysis was conducted to get a more accurate estimation of the association between Cdx-2 polymorphism and cancer risk.We identified 25 independent studies with a total of 34,018 subjects published prior to March 2015. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to cancer. Separate analyses were conducted on features of the population such as ethnicity, source of controls, and cancer types.Meta-analysis results showed that Cdx-2 polymorphism significantly increased cancer risk in the homozygous model in overall analysis. According to the further stratified analysis, significant association was found between Cdx-2 variant and cancer risk in American-Africans in the homozygous, recessive, and dominant comparison models. However, no significant associations were found in Caucasians and Asians. When stratified by different cancer types, significant association was observed between Cdx-2 variant and an increased risk of colorectal cancer in the homozygous, recessive, and dominant models. In addition, ovarian cancer susceptibility increased based on the homozygous and dominant comparison models.Our study indicated that VDR Cdx-2 polymorphism was associated with an increased cancer risk, particularly in American-Africans, colorectal, and ovarian cancers. However, other factors may impact on the association. Further multicenter studies are needed to confirm the effects of Cdx-2 polymorphism on cancer susceptibility.
From the Department of Hematology (Z-MD, W-GZ, JL, X-MC); Department of Anesthesia (Z-MD), and Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China (SL, MW, Z-JD); Department of Neurology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China (Y-LF, Q-MQ); and Department of Hematological Genetics, Shaanxi Provincial People's Hospital, Xi'an, China (Y-CL).
Zhi-Ming
ZM
Dai
Yu-Lang
YL
Fei
Wang-Gang
WG
Zhang
Jie
J
Liu
Xing-Mei
XM
Cao
Qiu-Min
QM
Qu
Yan-Chun
YC
Li
Shuai
S
Lin
Meng
M
Wang
Zhi-Jun
ZJ
Dai
D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000145:classification / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol; C579457:VDR protein, human