IL-1 provokes electrical abnormalities in rat atrial myocardium.
Using a micro-electrode technique we studied the effects of interleukin 1α and interleukin 1β on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching. Perfusion with interleukin 1α increased the duration of the action potential at the level of 90% re-polarization. Stretch induced tachy-arrhythmia in the presence of interleukin 1α is mainly regulated via stretch increased nitric oxide production, while the ionotropic effect of the interleukin-1α during stretching is not pronounced. The perfusion with interleukin 1β did not change the values of the duration of the action potentials at the levels of 25, 50 and 90% repolarization. The interleukin lβ caused an appearance of extra-systolic patterns which turned into normal rhythm, alternating with periods of normal activity. The total intracellular nitric oxide level induced by both interleukin 1β and stretching is balanced by interleukin-1β induced cation influx.
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia. Electronic address: vmitrohin@gmail.com.
V M
VM
Mitrokhin
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, P.O. Box 162, 1000 Skopje, Macedonia. Electronic address: m.mitko@gmail.com.
M I
MI
Mladenov
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
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AG
Kamkin
D000818:Animals; D016280:Atrial Function, Right / Q000187:drug effects* / Q000276:immunology; D001696:Biomechanical Phenomena / Q000187:drug effects / Q000276:immunology; D003627:Data Interpretation, Statistical; D006325:Heart Atria / Q000187:drug effects* / Q000276:immunology / Q000503:physiopathology; D066298:In Vitro Techniques; D053582:Interleukin-1alpha / Q000276:immunology / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000276:immunology / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects* / Q000276:immunology; D017208:Rats, Wistar
D053582:Interleukin-1alpha; D053583:Interleukin-1beta
Action potential; Atrium; Heart; Interleukin 1; Stretch