Rocuronium: automatic infusion versus manual administration with TOF monitorisation.
TOF (train-of-four) monitoring provides objective data in application of neuromuscular blocking agent. Thus, applicator-based differences are eliminated and optimum muscle relaxation is maintained during operation. In the present study, we aimed to compare the effects of target-controlled infusion system and standard TOF monitoring, on use of rocuronium. ASA I-II patients, who were aged between 18 and 75 years and scheduled for elective abdominal surgery at Haydarpaşa Numune Training and Research Hospital, were enrolled in the study. In order to evaluate neuromuscular blockade, the patients in Group 1 were connected to the acceleromyography device of the target-controlled infusion pump (Veryark-CLMRIS-I-China) while the ones in Group 2 were connected to the routinely used acceleromyography device (TOF Watch SX). There was no significant difference between groups regarding patient characteristics, the durations of anaesthesia and surgery, quality of intubation, time to extubation and time to recovery (TOF ratio of 0.9). Intubation time was significantly longer in Group 1 (Automated group) as compared to Group 2 (Control group) (p < 0.05). The total rocuronium amount used in Group 1 was found to be significantly higher than the amount used in Group 2 (p < 0.05). There was no clinical evidence of residual neuromuscular blockage or reoccurrence of neuromuscular blockage in any patient in either group. Both methods can be used for administration of neuromuscular blocker agent during moderate time anesthesia. No advantage was noted when rocuronium was administered via automatical infusion pump during anaesthesia.
Department of Anaesthesiology and Intensive Care, Nigde Bor State Hospital, Nigde, Turkey. gulcin_ozturk@hotmail.com.
Fatma Gulcin
FG
Ozturk Arikan
Department of Anaesthesiology and Intensive Care, Fatih Sultan Mehmet Teaching and Research Hospital, Istanbul, Turkey.
Guldem
G
Turan
Department of Anaesthesiology and Intensive Care, Haydarpasa Numune Teaching and Research Hospital, Istanbul, Turkey.
Asu
A
Ozgultekin
Department of Anaesthesiology and Intensive Care, Trabzon Surmene State Hospital, Trabzon, Turkey.
Zubeyir
Z
Sivrikaya
Department of Anaesthesiology and Intensive Care, Nigde Bor State Hospital, Nigde, Turkey.
Bekir Cem
BC
Cosar
Department of Anaesthesiology and Intensive Care, Nigde State Hospital, Nigde, Turkey.
Dondu Nisa
DN
Onder
D000293:Adolescent; D000328:Adult; D000368:Aged; D060666:Airway Extubation; D000732:Androstanols / Q000008:administration & dosage*; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000379:methods; D000776:Anesthesiology / Q000379:methods; D002138:Calibration; D005283:Fentanyl / Q000008:administration & dosage; D006339:Heart Rate; D006801:Humans; D007442:Intubation, Intratracheal; D008875:Middle Aged; D015233:Models, Statistical; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D009125:Muscle Relaxants, Central / Q000008:administration & dosage; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage; D012008:Recurrence; D000077123:Rocuronium; D013599:Systole; D055815:Young Adult
D000732:Androstanols; D009125:Muscle Relaxants, Central; D003473:Neuromuscular Nondepolarizing Agents; D005283:Fentanyl; D000077123:Rocuronium; D015742:Propofol
General anaesthesia; Monitoring; Neuromuscular block; Rocuronium