Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
OBJECTIVE
To review the published literature on management strategies for lacrimal gland carcinomas.


METHODS
Review of relevant articles in PubMed published in English from the year of 1970 through September 2014.


RESULTS
A review of literature suggests that treatment strategies for adenoid cystic carcinoma of lacrimal gland are varied, but local control does not necessarily prevent future delayed distant relapse. Tumor size and histologic features of lacrimal gland carcinoma seem to be important prognostic features. With improved imaging modalities providing better tumor diagnosis and staging, and availability of more focused radiation delivery techniques, multimodality globe sparing management of lacrimal gland carcinomas may be possible in selected cases. The availability of targeted drugs based on the molecular signature of an individual lacrimal gland carcinoma may offer possible targeted treatments for patients with nonresectable or metastatic disease.


CONCLUSIONS
Given the rarity of lacrimal gland carcinoma, multi-institutional studies and consistent reporting of size and histologic type of tumors in the literature may be prudent. Particularly, multimodality globe-sparing treatment strategies should be studied further.
*Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.; †Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; ‡Rice University, Houston, Texas, U.S.A.
Kyung In
KI
Woo
Arim
A
Yeom
Bita
B
Esmaeli
D003528:Carcinoma, Adenoid Cystic / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005134:Eye Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D013508:Ophthalmologic Surgical Procedures; D015996:Survival Rate