[Risk factors for iron deficiency anemia in infants aged 6 to 12 months and its effects on neuropsychological development].
OBJECTIVE
To study the risk factors for moderate and severe iron deficiency anemia (IDA) in infants aged 6-12 months, and to preliminarily investigate the effects of IDA on the neuromotor development and temperament characteristics of infants.


METHODS
A total of 326 infants aged 6-12 months with IDA were classified into three groups: mild IDA (n=176), moderate IDA (n=111), and severe IDA (n=39) according to the severity of anemia. The risk factors for moderate or severe IDA were investigated by multivariate logistic regression analysis. Three hundred and forty-six infants without IDA who showed matched age, sex, and other backgrounds were selected as the control group. The Gesell Development Diagnosis Scale was used to evaluate children's mental development. The Temperament Scale for infants was used for evaluating children's temperament.


RESULTS
The univariate analysis showed that the severity of IDA was associated with sex, birth weight, gestational age, multiple birth, maternal anemia during pregnancy, and mother's lack of knowledge about IDA (P<0.05). Setting the mild IDA group as control, the multivariate logistic regression analysis showed that multiple birth, premature birth, low birth weight (<2500 g), maternal anemia during pregnancy, breast feeding, and mother's lack of knowledge about IDA were the risk factors for severe IDA (OR>1; P<0.05); premature birth, breast feeding, and mixed feeding were the risk factors for moderate IDA (OR>1; P<0.05). The IDA group had significantly lower scores in Gesell general development quotient, gross motor, adaptive behavior, and fine motor than the control group (P<0.05). The IDA group had higher percentages of children with difficulty and intermediate difficulty temperaments than the control group (P<0.05). The IDA group had significantly higher scores in activity level, rhythmicity, adaptability, and perseverance than the control group (P<0.05).


CONCLUSIONS
The severity of IDA is associated with premature birth, multiple birth, low birth weight, feeding pattern, maternal anemia during pregnancy and mother's lack of knowledge about IDA in infants aged 6-12 months. Infants with IDA have delayed neuromotor development and most of them have negative temperaments. More attention should be paid to mental and behavior problems for the infants. It is necessary to provide guidance for their parents in feeding and education.
Department of Pediatrics, Third Medical College, Zhongshan Bo'ai Hospital Affiliated to Southern Medical University, Zhongshan, Guangdong 528403, China. 495390899@qq.com.
Kang
K
Xu
Cui-Mei
CM
Zhang
Lian-Hong
LH
Huang
Si-Mao
SM
Fu
Yu-Ling
YL
Liu
Ang
A
Chen
Jun-Bin
JB
Ou
D018798:Anemia, Iron-Deficiency / Q000209:etiology*; D002657:Child Development; D005260:Female; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D016015:Logistic Models; D008297:Male; D011597:Psychomotor Performance; D012307:Risk Factors