Pandalisines A and B, novel indolizidine alkaloids from the leaves of Pandanus utilis.
Two novel alkaloids named pandalisines A (1) and B (2), constituting a new class of C8-substituted indolizidine moiety, were isolated from the leaves of Pandanus utilis. The structures of these new compounds were established by their mass and spectroscopic data. The absolute configuration was determined by the comparison of experimental CD and calculated ECD spectra. A plausible biosynthetic pathway for compounds 1 and 2 is advanced. The cytotoxic activities of the isolated alkaloids against A-549, Hep-G2, and MDA-MB-231 cancer cell lines were evaluated. The result showed that 1 and 2 are the first non-cytotoxic indolizidine alkaloids.
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yuan-Bin
YB
Cheng
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yi-Hong
YH
Tsai
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
I-Wen
IW
Lo
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chen-Chang
CC
Haung
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yu-Chi
YC
Tsai
Institute of Pharmaceutical Biology, Technische Universität Braunschweig, Braunschweig 38106, Germany.
Ludger
L
Beerhues
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt.
Mohamed
M
El-Shazly
Translational Research Center and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Ming-Feng
MF
Hou
Translational Research Center and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Shyng-Shiou
SS
Yuan
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chin-Chung
CC
Wu
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. Electronic address: aaronfrc@kmu.edu.tw.
Fang-Rong
FR
Chang
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan; Center of Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan. Electronic address: yachwu@mail.cmu.edu.tw.
Yang-Chang
YC
Wu
D045744:Cell Line, Tumor; D056945:Hep G2 Cells; D006801:Humans; D054836:Indolizidines / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D031673:Pandanaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*
D054836:Indolizidines; C000607839:pandalisine A; C000607840:pandalisine B
Alkaloid; Biosynthetic pathway; Indolizidine; Pandanus utilis