Systematic review and meta-analysis of the association between IL18RAP rs917997 and CCR3 rs6441961 polymorphisms with celiac disease risks.
OBJECTIVE
We performed a systematic review and meta-analysis to estimate the polymorphism effects of IL18RAP and CCR3 on celiac disease susceptibility.


METHODS
PubMed and Web of Science databases were searched (to June 2015) on IL18RAP rs917997 and CCR3 rs6441961 polymorphisms.


RESULTS
The meta-analysis included 16 and 7 studies for rs917997 and rs6441961, respectively. The minor risk A allele at both rs917997 and rs6441961 carried risks (odds ratios) of 1.24 (95% CI 1.18-1.31) and 1.21 (95% CI 1.12-1.31), respectively. These alleles contributed to increase risks in all celiac disease patients by 5.04 and 6.35%. The estimated lambdas were 0.73 and 0.51, suggesting that an additive model would be the best choice for both gene effects.


CONCLUSIONS
This meta-analysis provides robust estimates that IL18RAP rs917997 and CCR3 rs6441961 are potential risk factors for celiac disease in European populations. Studies are needed to confirm these findings in different ethnicities.
a 1 Department of Parasitology, School of Medicine, Jinan University, Guangzhou, China.
Guang
G
Yang
a 1 Department of Parasitology, School of Medicine, Jinan University, Guangzhou, China.
Baohuan
B
Zhang
b 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
Weihuang
W
Huang
b 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
Na
N
Zhang
b 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
Fang
F
Dong
b 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
Lipeng
L
Jing
b 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
Man
M
Wang
b 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
Yang
Y
Liu
b 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
Congcong
C
Guo
c 3 Department of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China.
Hongwei
H
Pan
d 4 Family Planning Research Institute of Guangdong, Guangzhou, China.
Xiangcai
X
Wei
b 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
Chunxia
C
Jing
D002446:Celiac Disease / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D053728:Interleukin-18 Receptor beta Subunit / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D054397:Receptors, CCR3 / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics*
C515350:CCR3 protein, human; C115629:IL18RAP protein, human; D053728:Interleukin-18 Receptor beta Subunit; D054397:Receptors, CCR3
CCR3; IL18RAP; celiac disease; genetic association studies; meta-analysis