Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging.
To enable tissue function-based tumor diagnosis over the large number of existing digital mammography systems worldwide, we propose a cost-effective and robust approach to incorporate tomographic optical tissue characterization with separately acquired digital mammograms. Using a flexible contour-based registration algorithm, we were able to incorporate an independently measured two-dimensional x-ray mammogram as structural priors in a joint optical/x-ray image reconstruction, resulting in improved spatial details in the optical images and robust optical property estimation. We validated this approach with a retrospective clinical study of 67 patients, including 30 malignant and 37 benign cases, and demonstrated that the proposed approach can help to distinguish malignant from solid benign lesions and fibroglandular tissues, with a performance comparable to the approach using spatially coregistered optical/x-ray measurements.
Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, United States.
Bin
B
Deng
Philips Research Medisys, 33 Rue de Verdun, Suresnes 92156, France.
Maxim
M
Fradkin
Philips Research Medisys, 33 Rue de Verdun, Suresnes 92156, France.
Jean-Michel
JM
Rouet
Massachusetts General Hospital, Department of Radiology, Boston, Massachusetts 02114, United States.
Richard H
RH
Moore
Massachusetts General Hospital, Department of Radiology, Boston, Massachusetts 02114, United States.
Daniel B
DB
Kopans
Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, United States.
David A
DA
Boas
Philips Healthcare, Smidesvägen 5, Solna 171 41, Sweden.
Mats
M
Lundqvist
Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, United States.
Qianqian
Q
Fang
D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008327:Mammography / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D041622:Tomography, Optical / Q000379:methods*