Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection?
Most research on American cranberry in the prevention of urinary tract infection (UTI) has used juices. The spectrum of components in juice is limited. This study tested whether whole cranberry fruit powder (proanthocyanidin content 0.56%) could prevent recurrent UTI in 182 women with two or more UTI episodes in the last year. Participants were randomized to a cranberry (n = 89) or a placebo group (n = 93) and received daily 500 mg of cranberry for 6 months. The number of UTI diagnoses was counted. The intent-to-treat analyses showed that in the cranberry group, the UTIs were significantly fewer [10.8% vs. 25.8%, p = 0.04, with an age-standardized 12-month UTI history (p = 0.01)]. The Kaplan-Meier survival curves showed that the cranberry group experienced a longer time to first UTI than the placebo group (p = 0.04). Biochemical parameters were normal, and there was no significant difference in urinary phenolics between the groups at baseline or on day180. The results show that cranberry fruit powder (peel, seeds, pulp) may reduce the risk of symptomatic UTI in women with a history of recurrent UTIs.
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515, Olomouc, Czech Republic.
Jitka
J
Vostalova
Department of Urology, University Hospital, I.P. Pavlova 5, 77500, Olomouc, Czech Republic.
Ales
A
Vidlar
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515, Olomouc, Czech Republic.
Vilim
V
Simanek
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515, Olomouc, Czech Republic.
Adela
A
Galandakova
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515, Olomouc, Czech Republic.
Pavel
P
Kosina
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515, Olomouc, Czech Republic.
Jan
J
Vacek
Institute of Molecular and Translational Medicine Department, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515, Olomouc, Czech Republic.
Jana
J
Vrbkova
Department of Nutritional and Food Sciences - Chair of Food and Technology and Food Biotechnology, University of Bonn, Römmerstrasse 164, 53117, Bonn, Germany.|Institut Prof. Dr. Georg Kurz GmbH, Stöckheimer Weg 1, 50829, Köln, Germany.
Benno F
BF
Zimmermann
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515, Olomouc, Czech Republic.
Jitka
J
Ulrichova
Department of Urology, University Hospital, I.P. Pavlova 5, 77500, Olomouc, Czech Republic.
Vladimir
V
Student
D000328:Adult; D005260:Female; D005638:Fruit; D006801:Humans; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D044945:Proanthocyanidins; D012639:Seeds; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000517:prevention & control; D029799:Vaccinium macrocarpon / Q000737:chemistry; D055815:Young Adult
D010936:Plant Extracts; D044945:Proanthocyanidins; C013221:proanthocyanidin
Vaccinium macrocarpon; clinical chemistry markers; haematology; recurrent; urinary metabolites; urinary tract infection