P(NMe2)3-mediated reductive [1+4] annulation of isatins with enones: a facile synthesis of spirooxindole-dihydrofurans.
A novel P(NMe2)3-mediated reductive [1+4] annulation reaction between isatins and enones has been developed, providing the facile synthesis of spirooxindole-dihydrofurans. This reaction unveils the first practical approach to construct five-membered cyclic motifs via a Kukhtin-Ramirez adduct involved [1+4] annulation mode.
College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan, 030024, P. R. China. zhourong@tyut.edu.cn.
Rong
R
Zhou
Kai
K
Zhang
Yusong
Y
Chen
Qiang
Q
Meng
Yiyi
Y
Liu
Ruifeng
R
Li
Zhengjie
Z
He
D005663:Furans / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D007510:Isatin / Q000737:chemistry*; D010084:Oxidation-Reduction
D005663:Furans; D007211:Indoles; D007510:Isatin