Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159.
In this study, we revealed that OA and UA significantly inhibited the expression of most genes related to peptidoglycan biosynthesis in S. mutans UA159. To the best of our knowledge, this is the first report to introduce the antimicrobial mechanism of OA and UA against S. mutans.
Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju, >Republic of Korea, Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju, Republic of Korea.
Soon-Nang
SN
Park
Seoul National University, School of Dentistry, Seoul National University, Seoul, >Republic of Korea, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Sug-Joon
SJ
Ahn
Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju, >Republic of Korea, Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju, Republic of Korea.
Joong-Ki
JK
Kook
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D053898:Biosynthetic Pathways / Q000187:drug effects* / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D009828:Oleanolic Acid / Q000494:pharmacology*; D010457:Peptidoglycan / Q000096:biosynthesis*; D013295:Streptococcus mutans / Q000187:drug effects*; D014315:Triterpenes / Q000494:pharmacology*; D000097245:Ursolic Acid
D000900:Anti-Bacterial Agents; D009828:Oleanolic Acid; D010457:Peptidoglycan; D014315:Triterpenes; D000097245:Ursolic Acid
Streptococcus mutans UA159; oleanolic acid; peptidoglycan biosynthesis; ursolic acid