Pediatric Metastatic Odontogenic Ghost Cell Carcinoma: A Multimodal Treatment Approach.
Odontogenic ghost cell carcinoma (OGCC) is a rare and aggressive tumor wherein optimal treatment remains uncertain. We report the first pediatric metastatic OGCC case treated with multimodal therapy: surgery, adjuvant chemoradiation, and adjuvant immunotherapy. Adjuvant therapy was utilized due to locally advanced disease with pathologic features indicative of high recurrence risk. This multimodal approach was modeled after management of primary head and neck cancer, where adjuvant chemoradiation and immunotherapy are associated with improved outcomes. Our patient is alive and disease free at 14 months indicating a potentially positive role for multimodal therapy in the management of OGCC.
Department of Radiation Oncology, Mayo Clinic , Rochester, MN.
Safia K
SK
Ahmed
Department of Cancer and Blood Disorders, Phoenix Children's Hospital , AZ.
Masayo
M
Watanabe
Department of Pathology and Laboratory Medicine, Phoenix Children's Hospital , AZ.
Daphne E
DE
deMello
Department of Radiation Oncology, Mayo Clinic , Phoenix, AZ, USA.
Thomas B
TB
Daniels
Odontogenic ghost cell carcinoma; chemotherapy; immunotherapy; pediatric; radiation