Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden.
OBJECTIVE
Non-alcohol fatty liver disease (NAFLD) is a strong risk factor for insulin resistance and type 2 diabetes. The prevalence of NAFLD varies across populations of different ethnic backgrounds but the prevalence in Middle Eastern populations, which are at high risk of type 2 diabetes, is largely unknown. Using fatty liver index (FLI) as a proxy for NAFLD the aim was to calculate the odds of NAFLD (FLI≥70) given country of origin and further to investigate the associations between ISI and FLI.


METHODS
In 2010-2012 we conducted a population-based study of individuals aged 30-75 years born in Iraq or Sweden, in whom anthropometrics, fasting blood samples and oral glucose tolerance tests were performed and sociodemography and lifestyle behaviors characterized.


RESULTS
A higher proportion of Iraqis (N=1085) than Swedes (N=605) had a high probability of NAFLD (FLI≥70, 32.5 vs. 22.6%, p<0.001, age- and sex-adjusted data) and ISI was more severely impaired (70.7 vs. 95.9%, p<0.001). Independently of traditional risk factors for NAFLD, being born in Iraqi increased the risk of FLI≥70 (OR 1.59: 95% CI 1.15, 2.20). Furthermore, country of birth presented a stronger association between ISI and FLI≥70 in Iraqis than in Swedes (P(interaction)=0.019).


CONCLUSIONS
Our data indicate that immigrants from Iraq are at higher risk of NAFLD. The finding that country of birth modifies the relationship of FLI with ISI, suggests that liver fat may be a stronger determinant of impaired insulin action and increased risk of type 2 diabetes in Iraqis than in Swedes.
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Family Medicine, Lund University, Malmö, Sweden; Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Malmö, Sweden. Electronic address: Louise.Bennet@med.lu.se.
Louise
L
Bennet
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Leif
L
Groop
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Paul W
PW
Franks
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000208:ethnology* / Q000378:metabolism; D054242:Emigrants and Immigrants / Q000706:statistics & numerical data; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin; D007333:Insulin Resistance; D007493:Iraq / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D008877:Middle East / Q000208:ethnology; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000208:ethnology* / Q000378:metabolism; D015995:Prevalence; D044469:Racial Groups / Q000706:statistics & numerical data; D012111:Residence Characteristics / Q000706:statistics & numerical data*; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology
D007328:Insulin
Insulin sensitivity; Middle East; Non-alcohol fatty liver disease; Type 2 diabetes