Association between 8473T>C polymorphism in the cyclooxygenase-2 gene and the risk of nasopharyngeal carcinoma.
BACKGROUND
No studies have examined the relationship between COX-2 8473T>C polymorphism and the risk of nasopharyngeal carcinoma in Chinese population.


METHODS
296 patients with nasopharyngeal carcinoma and 300 age and gender-matched healthy controls recruited were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Cancer risk associated with the genotypes was estimated as odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditioned logistic regression.


RESULTS
There was significant difference in the distribution of COX-2 8473T>C polymorphism genotype between nasopharyngeal carcinoma patients and healthy controls (P=0.027). When the TT genotype was used as the reference group, the CC genotype was associated with significantly decreased risk for nasopharyngeal carcinoma (adjusted OR=0.67, 95% CI=0.33-0.83; P=0.01). Under the recessive model of inheritance, the CC genotype was associated with significantly decreased risk for nasopharyngeal carcinoma (adjusted OR=0.43, 95% CI=0.37-0.81; P=0.007). Furthermore, the C allele was associated with significantly decreased risk for nasopharyngeal carcinoma (adjusted OR=0.48, 95% CI=0.39-0.85; P=0.009).


CONCLUSIONS
These data suggested that COX-2 8473T>C polymorphism was associated with reduced risk of nasopharyngeal carcinoma.
Department of Otolaryngol Head Neck Surgery, General Hospital of Tianjin Medical University Tianjin 300000, China.
Jian-Ling
JL
Wang
Department of Otolaryngol Head Neck Surgery, General Hospital of Tianjin Medical University Tianjin 300000, China.
Xin
X
Wang
Department of Otolaryngol Head Neck Surgery, General Hospital of Tianjin Medical University Tianjin 300000, China.
Dong
D
Yang
Department of Otolaryngol Head Neck Surgery, Tianjin First Central Hospital Tianjin 300000, China.
Wen-Jie
WJ
Shi
D000368:Aged; D044466:Asian People / Q000235:genetics; D002277:Carcinoma; D051546:Cyclooxygenase 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D051546:Cyclooxygenase 2
Cox-2; Nasopharyngeal carcinoma; polymorphism; risk