[IMPACT OF LONG-TERM ADAPTATION TO COLD ON THE STATE OF CARDIOVASCULAR SYSTEM].
The inhabitancy in Far North increases a probability of development of coronary heart disease, acute myocardial infarction and arterial hypertension. Catecholamines and NO deficiency play a substantial role in the development of cold hypertension but are not involved in acclimatization cardiac hypertrophy. Data of in vivo experiments indicate in favor of an involvement of α-adrenergic receptors (ARs) in the mechanism of an appearance of cold hypertension. Cold acclimatization promotes an elevation of β3-AR density and decrease in β1-AR and β2-AR quantity on sarcolemma of cardiomyocytes. Experimental data indicate about the important role of aldosterone and angiotensin-II in the development of acclimatization hypertension. Catecholamines, aldosterone and angiotensin-II are not involved in cold hypertrophy of heart. Experimental data say on the important role of endothelin ETA-receptor in the formation of cold hypertrophy of heart and cardiofibrosis. Thyroid hormones play substantial role in the development of cold hypertension and cardiac hypertrophy.
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Maslov
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Naryzhnaia
D000064:Acclimatization; D000222:Adaptation, Physiological; D000450:Aldosterone / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001110:Arctic Regions; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000503:physiopathology*; D002395:Catecholamines / Q000378:metabolism; D003080:Cold Temperature; D003327:Coronary Disease / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism
D002395:Catecholamines; D011942:Receptors, Adrenergic, alpha; D000804:Angiotensin II; D000450:Aldosterone