Mechanisms of Acupuncture Effect on Alzheimer's Disease in Animal- Based Researches.
Alzheimer's disease is the most common type of dementia in the aging population worldwide. The etiology and treatment of Alzheimer's disease are still not very clear. Finding a new treatment is urgent due to the increasing population aging. Acupuncture has been practicing in China for more than 3000 years and reported to be beneficial in treating cognitive impairment of Alzheimer's disease. This paper reviews the recent development on the effect of acupuncture on Alzheimer's disease in animal-based researches. It is suggested that acupuncture improves cognitive function of Alzheimer's disease by regulating glucose metabolism, enhancing neurotransmission as well as reducing oxidative stress, Aβ protein deposition, and neuronal apoptosis. However, it is still difficult to clarify which specific signaling pathway contributes to the acupuncture effect. Better designed studies are recommended to investigate the effects of acupuncture on Alzheimer's disease.
Yan
Y
Cao
Li-Wen
LW
Zhang
Jian
J
Wang
Si-Qi
SQ
Du
Ling-Yong
LY
Xiao
Jian-Feng
JF
Tu
Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, P.R. China. lcz623780@126.com.
Cun-Zhi
CZ
Liu
D015670:Acupuncture Therapy; D000544:Alzheimer Disease / Q000378:metabolism / Q000628:therapy*; D000818:Animals; D003072:Cognition Disorders / Q000378:metabolism / Q000628:therapy; D004195:Disease Models, Animal