Comparative analysis of the effectiveness of abiraterone before and after docetaxel in patients with metastatic castration-resistant prostate cancer.
OBJECTIVE
To study the efficacy and safety of abiraterone in patients with and without prior chemotherapy.


METHODS
The databases including PubMed and abstracts presented at the American Society of Clinical Oncology meetings up to April 2014 were systematically searched. Eligible studies included randomized controlled trials (RCTs) in which abiraterone plus prednisone was compared to placebo plus prednisone in metastatic castration-resistant prostate cancer (CRPC) patients. The summary incidence, relative risk, hazard ratio and 95%CI were calculated using random or fixed-effects models. Heterogeneity test was performed to test between-study differences in efficacy and toxicity.


RESULTS
A total of two phase III RCTs were included in our analysis, with metastatic CPRC patients before (n = 1088) and after chemotherapy (n = 1195). Prior chemotherapy did not significantly alter the effect of abiraterone on overall survival (P = 0.92) and prostate-specific antigen (PSA) progression-free survival (P = 0.13), but reduced its effect on radiographic-progression-free survival (P = 0.04), objective response rate (P < 0.001), and PSA response rate (P < 0.001). Prior chemotherapy significantly increased the specific risk of fluid retention and edema (P < 0.001) and hypokalemia (P < 0.001), but decreased the risk of all-grade hypertension (P < 0.001) attributable to abiraterone. There was no significant difference of cardiac disorders associated with abiraterone between the two settings (P = 0.58).


CONCLUSIONS
Prior chemotherapy may reduce the effectiveness of abiraterone in patients with metastatic CRPC.
Raji Shameem, Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States.
Raji
R
Shameem
Raji Shameem, Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States.
Muhammad Saad
MS
Hamid
Raji Shameem, Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States.
Kevin Y
KY
Xu
Raji Shameem, Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States.
Shenhong
S
Wu
Abiraterone; Chemotherapy-naïve; Docetaxel; Metastatic castration-resistant prostate cancer; Post-chemotherapy; Pre-chemotherapy