The safety and tolerability of adenosine as a pharmacological stressor in stress perfusion cardiac magnetic resonance imaging in the Chinese population.
OBJECTIVE
To investigate the safety profile and effectiveness of adenosine as a pharmacological stressor in patients with known or suspected coronary artery disease who underwent cardiac magnetic resonance imaging perfusion study.


METHODS
Regional hospital, Hong Kong.


METHODS
All patients who underwent adenosine stress cardiac magnetic resonance imaging from May 2013 to August 2013 were prospectively interviewed during the scan.


METHODS
Common side-effects of adenosine as well as any other discomfort experienced during the scan were recorded. Haemodynamic changes including systolic and diastolic blood pressure and pulse rate before and during adenosine administration were also recorded.


RESULTS
There were 98 consecutive patients with a mean (± standard deviation) age of 64.0 ± 11.4 years (range, 10-83 years) and mean body weight of 67.5 ± 12.0 kg. Male-to-female ratio was 2.5:1. Of the 98 patients interviewed, 62 (63.3%) experienced one or more adenosine-associated adverse effects. Chest discomfort was most frequently experienced (48.0%), followed by dyspnoea (29.6%) and headache (20.4%). No life-threatening event occurred. Following adenosine administration, a significant rise in pulse rate (75.1 ± 14.3 vs 93.2 ± 14.7 beats/min; P<0.01) and a significant drop in diastolic blood pressure (75.1 ± 13.3 vs 68.0 ± 13.9 mm Hg; P<0.01) were noted. There was a general decrease in systolic blood pressure, although no statistically significant difference was observed (144.9 ± 17.6 vs 143.1 ± 21.4 mm Hg; P=0.18).


CONCLUSIONS
Adenosine stress cardiac magnetic resonance perfusion study is safe and well tolerated in clinical practice.
Department of Radiology and Imaging, Queen Elizabeth Hospital, Jordan, Hong Kong.
K H
KH
Tsang
Department of Radiology and Imaging, Queen Elizabeth Hospital, Jordan, Hong Kong.
Winnie S W
WS
Chan
Department of Radiology and Imaging, Queen Elizabeth Hospital, Jordan, Hong Kong.
C K
CK
Shiu
Department of Radiology and Imaging, Queen Elizabeth Hospital, Jordan, Hong Kong.
M K
MK
Chan
D000241:Adenosine / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001794:Blood Pressure / Q000187:drug effects; D002637:Chest Pain / Q000139:chemically induced; D002648:Child; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology; D004417:Dyspnea / Q000139:chemically induced; D005260:Female; D006261:Headache / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006723:Hong Kong; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014665:Vasodilator Agents / Q000009:adverse effects*; D055815:Young Adult
D014665:Vasodilator Agents; D000241:Adenosine
Adenosine; Magnetic resonance imaging, cine; Myocardial ischemia