Effects of Alendronate Sodium Content on the Interface Strengths of Composite Acrylic Bone Cement.
Objective. Aim to study how the content of alendronate affected shear strengths at bone-bone cement-metal interfaces. Methods. All samples were divided into 6 groups, G0-G5. On the 1st and 60th day after surgery, bone-bone cement interface shear strengths and bone densities were examined. Interface strengths of metal-bone cement specimens were studied before immersion and 4 weeks after immersion. Results. On the 60th day, bone-bone cement interface shear strengths and bone densities showed significant differences (P < 0.05), and compared with G0, G2-G5 values increased significantly (P < 0.05), and the peak value was met in G3. Compared with the 1st day, on the 60th postoperative day both factors decreased significantly in G0 and G1 (P < 0.05). Four weeks after immersion, with the increasing dose of alendronate, the shear strengths decreased gradually and in G5 decreased significantly (P < 0.05). Compared with before immersion, the metal-bone cement interface strengths decreased significantly 4 weeks after immersion (P < 0.05). Conclusions. 50-500 mg alendronate in 50 g cement powders could prevent the decrease of shear strengths at bone-bone cement interfaces and had no effect on metal-bone cement interface strengths. While the addition dose was 100 mg, bone cement showed the best strengths.
Department of Orthopaedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
De-Ye
DY
Song
Department of Orthopaedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Xin-Zhan
XZ
Mao
Department of Orthopaedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Mu-Liang
ML
Ding
Department of Orthopaedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Jiang-Dong
JD
Ni