Numerical Investigation of the Residual Stress Distribution of Flat-Faced and Convexly Curved Tablets Using the Finite Element Method.
The stress distribution of tablets after compression was simulated using a finite element method, where the powder was defined by the Drucker-Prager cap model. The effect of tablet shape, identified by the surface curvature, on the residual stress distribution was investigated. In flat-faced tablets, weak positive shear stress remained from the top and bottom die walls toward the center of the tablet. In the case of the convexly curved tablet, strong positive shear stress remained on the upper side and in the intermediate part between the die wall and the center of the tablet. In the case of x-axial stress, negative values were observed for all tablets, suggesting that the x-axial force always acts from the die wall toward the center of the tablet. In the flat tablet, negative x-axial stress remained from the upper edge to the center bottom. The x-axial stress distribution differed between the flat and convexly curved tablets. Weak stress remained in the y-axial direction of the flat tablet, whereas an upward force remained at the center of the convexly curved tablet. By employing multiple linear regression analysis, the mechanical properties of the tablets were predicted accurately as functions of their residual stress distribution. However, the multiple linear regression prediction of the dissolution parameters of acetaminophen, used here as a model drug, was limited, suggesting that the dissolution of active ingredients is not a simple process; further investigation is needed to enable accurate predictions of dissolution parameters.
Department of Pharmaceutics, Hoshi University.
Saori
S
Otoguro
Yoshihiro
Y
Hayashi
Takahiro
T
Miura
Naoto
N
Uehara
Shunichi
S
Utsumi
Yoshinori
Y
Onuki
Yasuko
Y
Obata
Kozo
K
Takayama
D000082:Acetaminophen / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry*; D003198:Computer Simulation; D055119:Elastic Modulus; D005079:Excipients / Q000737:chemistry; D020342:Finite Element Analysis; D008956:Models, Chemical; D011208:Powders / Q000737:chemistry; D012995:Solubility; D013314:Stress, Mechanical; D013607:Tablets / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013718:Tensile Strength
D018712:Analgesics, Non-Narcotic; D005079:Excipients; D011208:Powders; D013607:Tablets; D000082:Acetaminophen