Lupane- and Friedelane-Type Triterpenoids from Celastrus stylosus.
Two new triterpenoids, 30-hydroxylup-20(29)-ene 3β-caffeate (1) and 24-nor-friedelan-6α,10-dihydroxy-1,2-dioxo-4,7-dien-29-oic acid (2), together with eight known compounds 3-10, were isolated from the roots of Celastrus stylosus. The structures of these compounds were elucidated on the basis of spectroscopic analyses. To the best of our knowledge, this represents the first study on the chemical constituents of C. stylosus. The antiproliferative activities of the triterpenoids against six human cancer cell lines (PANC-1, A549, PC-3, HepG2, SGC-7901, and HCCLM3) were evaluated. Compounds 3, 4, and 10 exhibited comparable activities against PC-3 and HCCLM3 cell lines as the positive control taxol.
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).|Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
You-Min
YM
Ying
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
Cui-Yu
CY
Li
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
Yan
Y
Chen
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
Jia-Gui
JG
Xiang
Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
Ling
L
Fang
Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
Jian-Biao
JB
Yao
Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province and College of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, P. R. China.
Fa-Song
FS
Wang
Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
Ru-Wei
RW
Wang
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)). tianranyaowu@zjut.edu.cn.
Wei-Guang
WG
Shan
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)). zjnpr@zjut.edu.cn.
Zha-Jun
ZJ
Zhan
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031247:Celastrus / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C421805:friedelane; C480546:lupane; D053978:Pentacyclic Triterpenes
Antiproliferative activities; Celastrus stylosus; Friedelanes; Lupanes; Triterpenoids