Memory NK Cells Take Out the (Mitochondrial) Garbage.
The molecular mechanisms important to generate innate natural killer cell "memory" are poorly understood. In this issue of Immunity, O'Sullivan et al. (2015) demonstrate that mitophagy plays a critical role in natural killer cell memory formation following viral infection.
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Julia A
JA
Wagner
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: tfehnige@wustl.edu.
Todd A
TA
Fehniger
D000818:Animals; D006566:Herpesviridae Infections / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D063306:Mitophagy / Q000235:genetics*; D018146:Muromegalovirus / Q000276:immunology*
D008565:Membrane Proteins; D024101:Mitochondrial Proteins