Enantio- and diastereoselective synthesis of γ-amino alcohols.
The γ-amino alcohol structural motif is often encountered in drugs and natural products. We developed two complementary catalytic diastereoselective methods for the synthesis of N-PMP-protected γ-amino alcohols from the corresponding ketones. The anti-products were obtained through Ir-catalyzed asymmetric transfer hydrogenation, the syn-products via Rh-catalyzed asymmetric hydrogenation.
Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, NL-6525 AJ Nijmegen, The Netherlands. f.rutjes@science.ru.nl.
Jorge M M
JM
Verkade
Peter J L M
PJ
Quaedflieg
Gerard K M
GK
Verzijl
Laurent
L
Lefort
Floris L
FL
van Delft
Johannes G
JG
de Vries
Floris P J T
FP
Rutjes
D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D013237:Stereoisomerism
D000605:Amino Alcohols