Informative gene network for chemotherapy-induced peripheral neuropathy.
BACKGROUND
Host genetic variability has been implicated in chemotherapy-induced peripheral neuropathy (CIPN). A dose-limiting toxicity for chemotherapy agents, CIPN is also a debilitating condition that may progress to chronic neuropathic pain. We utilized a bioinformatics approach, which captures the complexity of intracellular and intercellular interactions, to identify genes for CIPN.


METHODS
Using genes pooled from the literature as a starting point, we used Ingenuity Pathway Analysis (IPA) to generate gene networks for CIPN.


RESULTS
We performed IPA core analysis for genes associated with platinum-, taxane- and platinum-taxane-induced neuropathy. We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy.


CONCLUSIONS
Neurotoxicity is common in cancer patients treated with platinum compounds and anti-microtubule agents and CIPN is one of the debilitating sequela. The bioinformatic approach helped identify genes associated with CIPN in cancer patients.
Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
Cielito C
CC
Reyes-Gibby
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
Jian
J
Wang
Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
Sai-Ching J
SJ
Yeung
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.|Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
Sanjay
S
Shete