Papular Clear Cell Hyperplasia of the Eccrine Duct: A Precursor Lesion of Clear Cell Syringoma?
We report the case of a 77-year-old diabetic patient with asymptomatic papular eruption developed over a cutaneous scar after the resection of a squamous cell carcinoma. Histological examination revealed a clear cell proliferation involving the secretory portion of the eccrine glands. This entity has been previously named as papular clear cell hyperplasia of the eccrine duct. This clear cell change might be caused by glycogen deposition because of diabetes. We postulate that papular clear cell hyperplasia could be a precursor lesion of clear cell syringoma.
Department of Pathology, Hospital Universitario 12 de Octubre, Instituto de investigación i+12 Madrid, Universidad Complutense, Madrid, Spain.
Marina
M
Alonso-Riaño
Maria
M
Cámara-Jurado
Maria C
MC
Garrido
Jose L
JL
Rodríguez-Peralto
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D002921:Cicatrix / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004439:Eccrine Glands / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D012878:Skin Neoplasms / Q000453:epidemiology; D013544:Sweat Gland Neoplasms / Q000473:pathology; D018252:Syringoma / Q000473:pathology