Trabecular Plate Loss and Deteriorating Elastic Modulus of Femoral Trabecular Bone in Intertrochanteric Hip Fractures.
Osteoporotic hip fracture is associated with significant trabecular bone loss, which is typically characterized as low bone density by dual-energy X-ray absorptiometry (DXA) and altered microstructure by micro-computed tomography (μCT). Emerging morphological analysis techniques, e.g. individual trabecula segmentation (ITS), can provide additional insights into changes in plate-like and rod-like trabeculae, two major microstructural types serving different roles in determining bone strength. Using ITS, we evaluated trabecular microstructure of intertrochanteric bone cores obtained from 23 patients undergoing hip replacement surgery for intertrochanteric fracture and 22 cadaveric controls. Micro-finite element (μFE) analyses were performed to further understand how the abnormalities seen by ITS might translate into effects on bone strength. ITS analyses revealed that, near fracture site, plate-like trabeculae were seriously depleted in fracture patients, but trabecular rod volume was maintained. Besides, decreased plate area and rod length were observed in fracture patients. Fracture patients also showed decreased elastic moduli and shear moduli of trabecular bone. These results provided evidence that in intertrochanteric hip fracture, preferential loss of plate-like trabeculae led to more rod-like microstructure and deteriorated mechanical competence adjacent to the fracture site, which increased our understanding of the biomechanical pathogenesis of hip fracture in osteoporosis.
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University , New York, New York 10027, USA.
Ji
J
Wang
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University , New York, New York 10027, USA.
Bin
B
Zhou
Bone and Joint Research Lab, SA Pathology and Discipline of Anatomy and Pathology, University of Adelaide , Adelaide, Australia.
Ian
I
Parkinson
Section of Oral Anatomy and Surgery, The Melbourne Dental School, University of Melbourne , Victoria 3010, Australia.
C David L
CD
Thomas
Section of Oral Anatomy and Surgery, The Melbourne Dental School, University of Melbourne , Victoria 3010, Australia.
John G
JG
Clement
Bone and Joint Research Lab, SA Pathology and Discipline of Anatomy and Pathology, University of Adelaide , Adelaide, Australia.
Nick
N
Fazzalari
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University , New York, New York 10027, USA.
X Edward
XE
Guo
finite element; hip fracture; individual trabecula segmentation; intertrochanteric; microstructure