Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants (EpoRepair).
BACKGROUND
Preterm infants suffering from intraventricular hemorrhage (IVH) are at increased risk for neurodevelopmental impairment. Observational data suggest that recombinant human erythropoietin (rEPO) improves long-term cognitive outcome in infants with IVH. Recent studies revealed a beneficial effect of early high-dose rEPO on white matter development in preterm infants determined by magnetic resonance imaging (MRI).


OBJECTIVE
To summarize the current evidence and to delineate the study protocol of the EpoRepair trial (Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants).


METHODS
The study involves a review of the literature and the design of a double-blind, placebo-controlled, multicenter trial of repetitive high-dose rEPO administration, enrolling 120 very preterm infants with moderate-to-severe IVH diagnosed by cranial ultrasound in the first days of life, qualitative and quantitative MRI at term-equivalent age and long-term neurodevelopmental follow-up until 5 years of age.


CONCLUSIONS
The hypothesis generated by observational data that rEPO may improve long-term cognitive outcomes of preterm infants suffering from IVH are to be confirmed or refuted by the randomized controlled trial, EpoRepair.
Division of Neonatology, University of Basel Children's Hospital (UKBB), Basel, Germany.
Christoph M
CM
Rüegger
Cornelia F
CF
Hagmann
Christoph
C
Bührer
Leonhard
L
Held
Hans Ulrich
HU
Bucher
Sven
S
Wellmann
D020202:Cerebral Hemorrhage, Traumatic / Q000188:drug therapy*; D004311:Double-Blind Method; D000068817:Epoetin Alfa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008279:Magnetic Resonance Imaging; D008297:Male; D018579:Patient Selection; D066127:White Matter / Q000187:drug effects*
D000068817:Epoetin Alfa