Gorham's disease of the proximal tibia successfully treated with local administration of OK-432, followed by reconstruction with distraction osteogenesis: a case report.
Gorham's disease (GD) is a rare and intractable disease characterized by marked progression of osteolysis associated with lymphangioma and/or hemangioma. Here, we describe a case of GD of the proximal tibia occurring in a 10-year-old boy. Although we could not correctly diagnose it at first, we finally diagnosed him as having GD. Progression of osteolysis of the tibia stopped 3 months after the local administration of OK-432. Thereafter, the huge bone defect with varus and extension deformity was reconstructed successfully by distraction osteogenesis using the Ilizarov method. The present case suggests that local administration of OK-432, followed by distraction osteogenesis is a treatment option for GD.
aDepartment of Orthopaedic Surgery, Iwase General Hospital bDepartment of Orthopaedic Surgery, Fukushima Medical University School of Medicine cDepartment of Orthopaedic Surgery, Fukushima General Health and Welfare Centre, Fukushima dDepartment of Orthopaedic Surgery, Aichi Aoitori Habilitation Center for Challenged, Aichi, Japan.
Eiki
E
Yamagishi
Akira
A
Takeda
Shinichi
S
Konno
Koichiro
K
Takeda
Seita
S
Hagino
Michiyuki
M
Hakozaki
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D008297:Male; D019857:Osteogenesis, Distraction / Q000379:methods*; D010015:Osteolysis, Essential / Q000628:therapy*; D010844:Picibanil / Q000627:therapeutic use*; D013977:Tibia / Q000601:surgery*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D010844:Picibanil