Improvement of Short-Term Outcomes for High-Risk Bleeding Peptic Ulcers With Addition of Argon Plasma Coagulation Following Endoscopic Injection Therapy: A Randomized Controlled Trial.
A second endoscopic method together with injection therapy is recommended to treat high-risk bleeding peptic ulcers. This study investigated whether additional argon plasma coagulation (APC) treatment could influence hemostatic efficacy following endoscopic injection therapy to treat high-risk bleeding ulcers.From October 2010 to January 2012, eligible patients with high-risk bleeding ulcers were admitted to our hospital. They prospectively randomly underwent either APC therapy along with distilled water injection or distilled water injection alone. Episodes of rebleeding were retreated with endoscopic combination therapy. Patients in whom retreatment was ineffective underwent emergency surgery or transarterial embolization (TAE).A total of 116 enrolled patients were analyzed. The hemostatic efficacy in 58 patients treated with APC along with distilled water injection was compared with that in 58 patients treated with distilled water injection alone. The 2 treatment groups were similar with respect to all baseline characteristics. Initial hemostasis was accomplished in 56 patients treated with combined therapy, and 55 patients treated with distilled water injection therapy (97% vs 95%, P = 0.648). Bleeding recurred in 2 patients treated with combined therapy, and 9 patients treated with distilled water injection (3.6% vs 16%, P = 0.029). Treatment method was the only independent prognostic factor for recurrent bleeding (odds ratio 0.17; 95% confidence interval 0.03-0.84; P = 0.029). The 2 groups did not differ significantly in hospital stay, TAE, surgery, and mortality.Endoscopic therapy with APC following distilled water injection is more effective than distilled water injection alone for preventing rebleeding of peptic ulcer.
From the Division of Gastroenterology (H-MW, W-LT, H-CY, H-HC, W-CC, K-HL, T-JT, S-SK, W-CS, P-IH), Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei; and Department of Biological Sciences (H-HC), National Sun Yat-sen University, Kaohsiung, Taiwan.
Huay-Min
HM
Wang
Wei-Lun
WL
Tsai
Hsien-Chung
HC
Yu
Hoi-Hung
HH
Chan
Wen-Chi
WC
Chen
Kung-Hung
KH
Lin
Tzung-Jiun
TJ
Tsai
Sung-Shuo
SS
Kao
Wei-Chih
WC
Sun
Ping-I
PI
Hsu
D000368:Aged; D057908:Argon Plasma Coagulation / Q000379:methods*; D005260:Female; D005773:Gastroscopy / Q000379:methods*; D006470:Hemorrhage / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000628:therapy*; D011446:Prospective Studies; D014867:Water / Q000008:administration & dosage*
D014867:Water