Expanding the lung donor pool: advancements and emerging pathways.
OBJECTIVE
The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of a shortage of organ donors and a low utilization rate of lungs from those donors who are available. In recent years, novel strategies have been developed to increase the donor lung pool: improved donor management, the use of lungs from donations after cardiac death (DCD), the use of lobar lung living-donors (LLLD) and the use of ex-vivo lung perfusion (EVLP) to assess and repair injured donor lungs.


RESULTS
An adapted donor management strategy could expand the donor pool up to 20%. DCD lung transplant is an increasing part of the donor pool expansion. Outcomes after controlled DCD seem to be similar to donation after brain death. LLLD transplantation has excellent results for small and critically ill patients. EVLP treatment allows for a significant increase in the rate of suitable lungs and represents an optimal platform for lung reconditioning and specific lung therapies.


CONCLUSIONS
A significant increase in the number of available lungs for transplantation is expected in the future because of the wider use of lungs from controlled or uncontrolled DCD and LLLD lungs, and with organ-specific EVLP treatment strategies.
Division of Thoracic Surgery, Toronto Lung Transplant Program, University of Toronto Toronto Lung Transplant Program, Latner Thoracic Surgery Research Laboratories, Toronto, Ontario, Canada.
Jeremie
J
Reeb
Shaf
S
Keshavjee
Marcelo
M
Cypel
D006801:Humans; D008168:Lung / Q000502:physiology* / Q000601:surgery; D016040:Lung Transplantation / Q000379:methods; D010477:Perfusion / Q000379:methods; D014019:Tissue Donors / Q000600:supply & distribution*