Drug-induced diseases (DIDs): An experience of a tertiary care teaching hospital from India.
OBJECTIVE
Drug-induced diseases (DIDs) are well known but least studied. Data on DIDs from India are not available. Hence, this retrospective cross-sectional study was undertaken using suspected adverse drug reaction (ADR) data collected form Pharmacovigilance Programme of India (PvPI) to evaluate profile of DIDs over two years, in a tertiary care teaching hospital from north India.


METHODS
The suspected ADRs in the form of DID were evaluated for drug and disease related variables and were classified in terms of causality.


RESULTS
DID rate was 38.80 per cent. Mean duration of developing DIDs was 26.05 ± 9.6 days; 25.16 per cent had more than one co-morbid condition. Geriatric population (53.99%) accounted for maximum DIDs followed by adult (37.79%) and paediatric (8.21%). Maximum events were probable (93.98%) followed by possible (6.04%). All DIDs required intervention. Gastritis (7.43%), diarrhoea (5.92%), anaemia (4.79%), hypotension (2.77%), hepatic dysfunction (2.69%), hypertension (1.51%), myalgia (1.05%), and renal dysfunction (1.01%) were some of the DIDs. Anti tubercular treatment (ATT), anti retroviral treatment (ART), ceftriaxone injection, steroids, non-steroidal anti-inflammatory drugs, antimicrobials and anticancer drugs were found as commonly offending drugs.


CONCLUSIONS
Our findings show that DIDs are a significant health problem in our country, which need more attention.
Postgraduate Department of Pharmacology and Therapeutics, Government Medical College, Jammu, India.
Vishal R
VR
Tandon
Vijay
V
Khajuria
Vivek
V
Mahajan
Aman
A
Sharma
Zahid
Z
Gillani
Annil
A
Mahajan
D000740:Anemia / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology; D003967:Diarrhea / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D005756:Gastritis / Q000139:chemically induced / Q000453:epidemiology* / Q000503:physiopathology*; D006784:Hospitals, Teaching; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology; D007194:India / Q000453:epidemiology; D008297:Male; D063806:Myalgia / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology; D060735:Pharmacovigilance; D051437:Renal Insufficiency / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology; D062606:Tertiary Care Centers