Bioconjugated Hydrogels for Tissue Engineering and Regenerative Medicine.
Hydrogels are hydrophilic polymer networks with high water content, which have played an important role as scaffolds for cells, as carriers for various biomolecules (e.g., drugs, genes, and soluble factors), and as injectable biomaterials in tissue engineering (TE) and regenerative medicine. Bioconjugation is an approach for improving the performance of hydrogels using cell-responsive components, such as proteins and peptides, which have high affinity to regulate cellular behaviors and tissue morphogenesis. However, the current knowledge on the role of those bioconjugated moieties in controlling cellular functions and tissue morphogenesis and bioconjugation methods are limited in the context of TE and organogenesis. Moreover, micro- and nanofabrication techniques have been used to manipulate bioconjugated hydrogels for regulating cell behaviors and function. This Review therefore describes synthesis, characteristics, and manipulation of various bioconjugated hydrogels and their potential in TE applications with special emphasis on preclinical/clinical translation.
WPI-Advanced Institute for Materials Research, Tohoku University , Sendai 980-8577, Japan.
Samad
S
Ahadian
WPI-Advanced Institute for Materials Research, Tohoku University , Sendai 980-8577, Japan.
Ramin Banan
RB
Sadeghian
WPI-Advanced Institute for Materials Research, Tohoku University , Sendai 980-8577, Japan.
Sahar
S
Salehi
WPI-Advanced Institute for Materials Research, Tohoku University , Sendai 980-8577, Japan.
Serge
S
Ostrovidov
College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University , Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea.
Hojae
H
Bae
WPI-Advanced Institute for Materials Research, Tohoku University , Sendai 980-8577, Japan.|Centre for Stem Cell Research, Institute for Stem Cell Biology and Regenerative Medicine, Christian Medical College Campus , Vellore 632002, India.
Murugan
M
Ramalingam
WPI-Advanced Institute for Materials Research, Tohoku University , Sendai 980-8577, Japan.|College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University , Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea.|Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School , Cambridge, Massachusetts 02139, United States.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Wyss Institute for Biologically Inspired Engineering, Harvard University , Boston, Massachusetts 02115, United States.|Department of Physics, Faculty of Science, King Abdulaziz University , Jeddah 21569, Saudi Arabia.
Ali
A
Khademhosseini
D000818:Animals; D001671:Biochemistry / Q000379:methods*; D001672:Biocompatible Materials; D002986:Clinical Trials as Topic; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D044085:Microfluidics / Q000379:methods; D010455:Peptides / Q000737:chemistry; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
D001672:Biocompatible Materials; D020100:Hydrogels; D010455:Peptides