Association of interleukin 3 (IL-3) polymorphisms with schizophrenia in Han Chinese population.
Schizophrenia has been observed to be associated with various abnormalities in multiple cytokines. Recent genetic analyses showed that the interleukin 3 (IL-3) gene and its receptors are significantly associated with schizophrenia, especially in Irish populations. To examine the associations of the Irish-risk single nucleotide polymorphisms (SNPs, e.g., rs3916441) in the IL-3 gene with schizophrenia in Chinese population, we utilized two independent samples from Southwestern China, including a total 901 schizophrenia patients and 1417 healthy controls. However, no statistically significant differences were observed in allelic or genotypic frequencies of the tested 6 SNPs in IL-3 between cases and controls in any sample. Therefore, the results of our analyses were not able to confirm the association of IL-3 SNPs with schizophrenia. The absence of the IL-3's association in Chinese population suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.
Key Laboratory of Special Biological Resource Development and Utilization of Universities in Yunnan Province, Department of Biological Science and Technology, Kunming University, Kunming, Yunnan, PR China.
Zichao
Z
Liu
First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, PR China.
Liang
L
Huang
Key Laboratory of Special Biological Resource Development and Utilization of Universities in Yunnan Province, Department of Biological Science and Technology, Kunming University, Kunming, Yunnan, PR China. Electronic address: wdk117@163.com.
Dingkang
D
Wang
School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, PR China. Electronic address: wulichuan@126.com.
Lichuan
L
Wu
D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
D007377:Interleukin-3
Chinese population; Interleukin 3; Schizophrenia; Single nucleotide polymorphism