[Gastro-esophageal Reflux Disease and malignant progression--equal risk for men and women?].
Gastroesophageal reflux disease (GERD) is highly prevalent in the Western world. Patients with GERD have a 10 fold increased risk to develop a Barrett's esophagus. Patients with Barrett's esophagus have a higher risk for an esophageal adenocarcinoma. Men have more severe reflux with a higher grade of inflammation and acid reflux. This seems to be the reason why men develop a Barrett's esophagus more frequently--the risk is approximately 2 to 3 fold and the risk for an esophageal adenocarcinoma is even 3 to 6 times higher.
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D000368:Aged; D001471:Barrett Esophagus / Q000175:diagnosis / Q000453:epidemiology*; D015984:Causality; D015897:Comorbidity; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D038622:Internationality; D008297:Male; D054526:Men's Health / Q000706:statistics & numerical data*; D008875:Middle Aged; D011230:Precancerous Conditions / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012727:Sex Characteristics; D017678:Sex Distribution; D016387:Women's Health / Q000706:statistics & numerical data*