Evaluation of lipid peroxidation and antioxidant status on fenvalerate, nitrate and their co-exposure in Bubalus bubalis.
The toxic effects of pesticides and minerals have been explored in different species, but still there is paucity of information regarding their combined toxicological effects. The present investigation reports oxidative stress induced by oral subacute exposure to fenvalerate (1 mg/kg) and sodium nitrate (20 mg/kg) alone, as well as in combination daily for 21 days in buffalo calves. Fenvalerate exposure produced significant elevation in lipid peroxidation (LPO), glutathione peroxidase (GPx), while it produced significant decline in blood glutathione (GSH) levels, superoxide dismutase (SOD) and catalase (CAT). No significant alteration was evidenced in nitric oxide (NOx) levels. Oral exposure to sodium nitrate produced significant inclination in LPO and NOx, while on the other hand significant depreciation in SOD and CAT with no significant change in GPx activity. Combined exposure to fenvalerate and sodium nitrate produced severe effects with an appreciably more prominent elevation in extent of LPO and decline in blood GSH levels.
Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India. Electronic address: kamalg27@yahoo.com.
Kamalpreet Kaur
KK
Gill
Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
Harpal Singh
HS
Sandhu
Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
Rajdeep
R
Kaur
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002020:Buffaloes; D002374:Catalase / Q000097:blood; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D009566:Nitrates / Q000008:administration & dosage*; D009569:Nitric Oxide / Q000378:metabolism; D009570:Nitriles / Q000008:administration & dosage*; D011722:Pyrethrins / Q000008:administration & dosage*; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D009566:Nitrates; D009570:Nitriles; D011722:Pyrethrins; D009569:Nitric Oxide; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; C017690:fenvalerate
Antioxidant status; Buffalo calves; Fenvalerate; Lipid peroxidation; Nitrate