ROR1C Regulates Differentiation of Myeloid-Derived Suppressor Cells.
Myeloid-derived suppressor cells (MDSCs) play a major role in cancer. MDSC expansion is closely associated with tumor progression, but molecular mechanisms of this expansion remain poorly understood. In this issue of Cancer Cell, Strauss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation of MDSC differentiation and expansion.
The Wistar Institute, 3601 Spruce Street, Room 180, Philadelphia, PA, 19104, USA. Electronic address: dgabrilovich@wistar.org.
Dmitry
D
Gabrilovich
The Wistar Institute, 3601 Spruce Street, Room 180, Philadelphia, PA, 19104, USA.
Yulia
Y
Nefedova
D000818:Animals; D005260:Female; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D038042:Myelopoiesis / Q000235:genetics*; D009374:Neoplasms, Experimental / Q000235:genetics*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000235:genetics*
D057132:Nuclear Receptor Subfamily 1, Group F, Member 3