Chlamydia pneumoniae-related hemophagocytic lymphohistiocytosis in an adult patient with clonal karyotype abnormality.
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease characterized by a severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages. Herein, we report a 58-year-old male who had Chlamydia pneumoniae-related pneumonia, followed by aggressive HLH. An abnormal cytogenetic profile was also detected. To our knowledge, this is the first report of an adult patient with C. pneumonia-associated HLH.
Zheng-Yi
ZY
Huang
Tzong-Shi
TS
Chieuh
Kwei-Shuai
KS
Hwang
Department of Medical, Division of Hematology and Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Tzu-Chuan
TC
Huang
D059786:Abnormal Karyotype; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D023521:Chlamydophila Infections / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule