Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats.
BACKGROUND
The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase of reperfusion (up to 90 min post-ischemia).


METHODS
Ischemia was established in anesthetized and mechanically ventilated male Wistar rats by renal artery clamping. Renal microvascular and venous oxygenation were measured using phosphorimetry. Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function.


RESULTS
The main findings were that BMOV did not affect the systemic and renal hemodynamic and oxygenation variables and partially protected renal sodium reabsorption.


CONCLUSIONS
Pretreatment with the organic vanadium compound BMOV did not protect the kidney from I/R injury.
Department of Intensive Care Adults, Erasmus MC University Medical Center Rotterdam, Center Rotterdam, PO Box 2040, Rotterdam, 3000 CA, The Netherlands, emreal@hotmail.com.
Emre
E
Almac
Rick
R
Bezemer
Asli
A
Kandil
Ugur
U
Aksu
Dan Mj
DM
Milstein
Jan
J
Bakker
Cihan
C
Demirci-Tansel
Can
C
Ince