Defining Plasma MicroRNAs Associated With Cognitive Impairment In HIV-Infected Patients.
Human Immunodeficiency Virus (HIV)-infected individuals are at increased risk for developing neurocognitive disorders and depression. These conditions collectively affect more than 50% of people living with HIV/AIDS and adversely impact adherence to HIV therapy. Thus, identification of early markers of neurocognitive impairment could lead to interventions that improve psychosocial functioning and slow or reverse disease progression through improved treatment adherence. Evidence has accumulated for the role and function of microRNAs in normal and pathological conditions. We have optimized a protocol to profile microRNAs in body fluids. Using this methodology, we have profiled plasma microRNA expression for 30 age-matched, HIV-infected (HIV(+) ) patients and identified highly sensitive and specific microRNA signatures distinguishing HIV(+) patients with cognitive impairment from those without cognitive impairment. These results justify follow-on studies to determine whether plasma microRNA signatures can be used as a screening or prognostic tool for HIV(+) patients with neurocognitive impairment. J. Cell. Physiol. 231: 829-836, 2016. © 2015 Wiley Periodicals, Inc.
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.|Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, Medical School, New Orleans, Louisiana.
Ferdous
F
Kadri
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Andrea
A
LaPlante
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Mariacristina
M
De Luca
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Lisa
L
Doyle
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Cruz
C
Velasco-Gonzalez
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Jonathan R
JR
Patterson
Department of Physiology, LSU Health Sciences Center, Medical School, New Orleans, Louisiana.
Patricia E
PE
Molina
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Steve
S
Nelson
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Arnold H
AH
Zea
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Christopher H
CH
Parsons
LSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Francesca
F
Peruzzi
D000328:Adult; D060825:Cognitive Dysfunction / Q000097:blood* / Q000150:complications* / Q000235:genetics; D003710:Demography; D015658:HIV Infections / Q000097:blood* / Q000150:complications* / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D012372:ROC Curve; D060888:Real-Time Polymerase Chain Reaction; D012015:Reference Standards; D015203:Reproducibility of Results
D035683:MicroRNAs