Studying the effects of dietary body weight-adjusted acute tryptophan depletion on punishment-related behavioral inhibition.
BACKGROUND
Alterations in serotonergic (5-HT) neurotransmission are thought to play a decisive role in affective disorders and impulse control.


OBJECTIVE
This study aims to reproduce and extend previous findings on the effects of acute tryptophan depletion (ATD) and subsequently diminished central 5-HT synthesis in a reinforced categorization task using a refined body weight-adjusted depletion protocol.


METHODS
Twenty-four young healthy adults (12 females, mean age [SD]=25.3 [2.1] years) were subjected to a double-blind within-subject crossover design. Each subject was administered both an ATD challenge and a balanced amino acid load (BAL) in two separate sessions in randomized order. Punishment-related behavioral inhibition was assessed using a forced choice go/no-go task that incorporated a variable payoff schedule.


RESULTS
Administration of ATD resulted in significant reductions in TRP measured in peripheral blood samples, indicating reductions of TRP influx across the blood-brain barrier and related brain 5-HT synthesis. Overall accuracy and response time performance were improved after ATD administration. The ability to adjust behavioral responses to aversive outcome magnitudes and behavioral adjustments following error contingent punishment remained intact after decreased brain 5-HT synthesis. A previously observed dissociation effect of ATD on punishment-induced inhibition was not observed.


CONCLUSIONS
Our results suggest that neurodietary challenges with ATD Moja-De have no detrimental effects on task performance and punishment-related inhibition in healthy adults.
Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.|JARA Translational Brain Medicine, Aachen & Jülich, Germany.
Tilman J
TJ
Gaber
Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Vita L S
VL
Dingerkus
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Molly J
MJ
Crockett
Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.|JARA Translational Brain Medicine, Aachen & Jülich, Germany.
Sarah
S
Bubenzer-Busch
Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.|JARA Translational Brain Medicine, Aachen & Jülich, Germany.
Katrin
K
Helmbold
Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.|JARA Translational Brain Medicine, Aachen & Jülich, Germany.
Cristina L
CL
Sánchez
Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.|JARA Translational Brain Medicine, Aachen & Jülich, Germany.
Brigitte
B
Dahmen
Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.|JARA Translational Brain Medicine, Aachen & Jülich, Germany.
Beate
B
Herpertz-Dahlmann
Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.|JARA Translational Brain Medicine, Aachen & Jülich, Germany.|Institute for Neuroscience and Medicine, Jülich Research Centre, Jülich, Germany.|Department of Child and Adolescent Psychiatry, School of Psychiatry and Clinical Neurosciences & School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Perth, Australia.|Specialised Child and Adolescent Mental Health Services (CAMHS), Department of Health in Western Australia, Perth, WA, Australia; florian.zepf@uwa.edu.au.
Florian D
FD
Zepf
acute tryptophan depletion; decision-making; executive functions; gender; serotonin