Ofloxacin Induced Cutaneous Reactions in Children.
Cutaneous adverse effects to antimicrobials are a major health problem. Though majority of them are mild and self-limiting, severe variants like Steven Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN) are not uncommon. Ofloxacin, a fluoroquinolone widely used for the treatment of urinary tract infections, acute bacterial diarrheas, enteric fever, STDs and other soft tissue infections either as a single drug or in combination with other drugs. Earlier a case of mucocutaneous maculopapular rash with oral ofloxacin and was reported in an adult. In the present hospital set up there were few reports of such reactions to adults. Here we report three different variants of reactions associated with oral ofloxacin in chlidren. Early detection of cutaneous lesions and immediate withdrawal of the offending drug can prevent progression of such reactions to their severe variants as well as morbidity and mortality.
Assistant Professor, Department of Pharmacology, MKCG Medical College , Berhampur, India .
Yerramalli Roja
YR
Ramani
Post Graduate, Department of Pharmacology, MKCG Medical College , Berhampur, India .
Sailen Kumar
SK
Mishra
Associate Professor, Department of Pharmacology, MKCG Medical College , Berhampur, India .
Bandana
B
Rath
Assistant Professor, Department of Paediatrics, MKCG Medical College , Berhampur, India .
Saroj Sekhar
SS
Rath
Children; Drug eruptions; Fluoroquinolones; Steven johnson syndrome