AdipoRon: a possible drug for colorectal cancer prevention?
Colorectal cancer (CRC) is in the third place of the most common cancers. Certain risk factors can increase the development of CRC, including diet and inheritance. Several studies have shown that there is a potential link between obesity and CRC. Adipose tissue is known to be a largest endocrine organ in the body, with the ability to produce various cytokines including adiponectin. Two types of adiponectin receptor, AdipoR1 and AdipoR2, have been detected in various cancer tissues such as CRC. There is mounting evidence that AdipoR1 signaling occurs mainly through 5' AMP-activated protein kinase (AMPK) and adiponectin inhibits colorectal cancer cell growth via activation of AMPK, thereby suppression of the mammalian target of rapamycin (mTOR) pathway. Thus, adiponectin replacement-based therapies may represent a novel approach in CRC cell growth inhibition in early stages. AdipoRon is an adiponectin-like synthetic small molecule that activated both adiponectin receptors 1 and 2. We hypothesize that AdipoRon has antiproliferative effects of adiponectin and may suppress the CRC cell growth. With clarification of this drug's role in CRC, it can be used as chemoprevention in patients at risk of developing the disease.
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Sara
S
Malih
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. re.najafi@umsha.ac.ir.
Rezvan
R
Najafi
D055372:AMP-Activated Protein Kinases / Q000235:genetics; D052242:Adiponectin / Q000235:genetics; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D006801:Humans; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D054419:Receptors, Adiponectin / Q000737:chemistry / Q000235:genetics* / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects
C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; C585113:AdipoRon; D052242:Adiponectin; D010880:Piperidines; D054419:Receptors, Adiponectin; D055372:AMP-Activated Protein Kinases
AdipoRon; Adiponectin; Adiponectin receptor 1; Adiponectin receptor 2; Colorectal cancer