Protective efficacy of stockpiled vaccine against H5N8 highly pathogenic avian influenza virus isolated from a chicken in Kumamoto prefecture, Japan, in 2014.
H5 highly pathogenic avian influenza (HPAI) viruses have spread worldwide, and antigenic variants of different clades have been selected. In this study, the national stockpiled vaccine prepared from A/duck/Hokkaido/Vac-1/2004 (H5N1) strain was evaluated for the protective efficacy against H5N8 HPAI virus isolated in Kumamoto prefecture, Japan, in April 2014. In the challenge test, all of the vaccinated chickens survived without showing any clinical signs and reduced virus shedding. It was concluded that the present stockpiled vaccine was effective against the H5N8 HPAI virus.
National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Koichiro
K
Gamoh
Mari
M
Nakamizo
Masatoshi
M
Okamatsu
Yoshihiro
Y
Sakoda
Hiroshi
H
Kida
Shoko
S
Suzuki
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002645:Chickens / Q000821:virology; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D007564:Japan; D011201:Poultry Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology
D000914:Antibodies, Viral; D007252:Influenza Vaccines