The molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteins.
MicroRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs found in most plants and animals. The miRNA pathway regulates posttranscriptional gene expression through the deadenylation and translation repression of target mRNAs. Recent studies revealed that the early step of translation initiation is the target of "pure" translation repression by the miRNA pathway. Moreover, particularly in animals, the miRNA pathway is required for neuronal development, differentiation, and plasticity. In addition, some functions of miRNAs are regulated by RNA-binding proteins (RBPs) in neuronal cells. This review summarizes new insights about the molecular mechanisms of pure translation repression by miRNA pathway and the communication between the miRNA pathway and RBPs in neuronal local translation.
a Laboratory of Biochemistry; Department of Pharmacy; Kinki University ; Higashi-Osaka , Japan.
Akira
A
Fukao
b Graduate School of Pharmaceutical Sciences; Nagoya City University ; Mizuho-ku, Nagoya , Japan.
Tomohiko
T
Aoyama
a Laboratory of Biochemistry; Department of Pharmacy; Kinki University ; Higashi-Osaka , Japan.
Toshinobu
T
Fujiwara
D000818:Animals; D015536:Down-Regulation; D005786:Gene Expression Regulation; D020868:Gene Silencing; D034502:Heterogeneous-Nuclear Ribonucleoprotein D / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D034743:RNA-Induced Silencing Complex / Q000378:metabolism
D034502:Heterogeneous-Nuclear Ribonucleoprotein D; D035683:MicroRNAs; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D034743:RNA-Induced Silencing Complex
RNA-binding protein; deadenylation; local translation; microRNA; pure translation