Three Colon Adenocarcinomas Arising in a Patient with Serrated Polyposis Syndrome: Case Report and Review of the Literature.
BACKGROUND
Serrated polyposis syndrome (SPS) is a rare entity mainly concerning the 6th decade of life and which is characterized by the presence of multiple large hyperplastic polyps, sessile serrated adenomas, and adenomas within the colon.


METHODS
We describe the case of a SPS patient with 3 synchronous adenocarcinomas. The morphologic features of serrated colorectal lesions, their characteristic molecular alterations, and their role in colorectal cancer development are discussed herein.


CONCLUSIONS
Our findings suggest that SPS is a rare condition with an increased risk for colon cancer. Patients suffering from SPS should have regular colonoscopic surveillance, and perhaps those with numerous dysplastic hyperplastic polyps should be treated with colectomy.
Department of Gastroenterology and Endoscopy Unit, Sismanogleion General Hospital, Marousi, Greece.
Emmanouil
E
Pyleris
Department of Gastroenterology and Endoscopy Unit, Sismanogleion General Hospital, Marousi, Greece.
Ioannis S
IS
Koutsounas
Department of Gastroenterology and Endoscopy Unit, Sismanogleion General Hospital, Marousi, Greece.
Panagiotis
P
Karantanos
Hyperplastic polyp; Serrated adenoma; Serrated neoplasia; Serrated polyposis syndrome