Expression of prostaglandin I2 (prostacyclin) receptor in blood of migraine patients: A potential biomarker.
BACKGROUND
Migraine is the most common chronic neurological disorders that may be associated with vasodilatation. According to the role of prostaglandin I2 (prostacyclin) receptor (PTGIR) in migraine as a receptor, which acts in vasodilatation, we decided to study the changes of PTGIR expression in migraine patients in relation to a suitable control group.


METHODS
Extracted mRNA from lymphocytes of 50 cases and 50 controls was used to synthesize cDNA. Real-time polymerase chain reaction was performed, and the data were analyzed. Our results show that PTGIR mRNA expression in cases was significantly higher than the control group (P = 0.010).


RESULTS
In conclusion, mRNA expression of PTGIR in the blood of people with migraines could be considered as a biomarker.


CONCLUSIONS
In addition, repression of PTGIR gene expression by methods such as using siRNA is probably suitable for therapy of migraine patients.
Department of Genetics and Molecular Biology, Pediatric Inherited Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Majid
M
Kheirollahi
Department of Genetics and Molecular Biology, Pediatric Inherited Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad
M
Kazemi
Department of Genetics and Molecular Biology, Pediatric Inherited Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Gilda
G
Amini
Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Fariborz
F
Khorvash
Department of Genetics and Molecular Biology, Pediatric Inherited Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh
F
Ahangari
Department of Genetics and Molecular Biology, Pediatric Inherited Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahsa
M
Kolahdouz
Department of Genetics and Molecular Biology, Pediatric Inherited Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Leila
L
Koulivand
Biomarker; expression; migraine; prostaglandin I2; receptor