Systemic and Mucosal Immune Responses toCryptosporidium-Vaccine Development.
Cryptosporidium sppis a major cause of diarrheal disease worldwide, particularly in malnourished children and untreated AIDS patients in developing countries in whom it can cause severe, chronic and debilitating disease. Unfortunately, there is no consistently effective drug for these vulnerable populations and no vaccine, partly due to a limited understanding of both the parasite and the host immune response. In this review, we will discuss our current understanding of the systemic and mucosal immune responses toCryptosporidiuminfection, discuss the feasibility of developing aCryptosporidiumvaccine and evaluate recent advances inCryptosporidiumvaccine development strategies.
Tufts University Sackler School of Graduate Biomedical Sciences and Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center.
Jacob G
JG
Ludington
Tufts University Sackler School of Graduate Biomedical Sciences and Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center.
Honorine D
HD
Ward
Cryptosporidium; immune response; mucosal; vaccine