A facile approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives via a three-component domino reaction.
A concise and efficient approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been accomplished by a three-component reaction involving sulfonyl acetonitrile, an aromatic aldehyde, and 6-aminouracil. The method involves the domino Knoevenagel condensation/Michael addition/cyclization cascade in the presence of triethylamine in refluxing ethanol.
Medicinal Chemistry Division, CSIR-North-East Institute of Science and Technology, Jorhat, Assam 785006, India. dr_dprajapati2003@yahoo.co.uk.
Yuvaraj
Y
Dommaraju
Shruti
S
Bora
Dipak
D
Prajapati
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry
D000447:Aldehydes; D011743:Pyrimidines; D014498:Uracil; C013400:6-aminouracil; C030986:pyrimidine