A vine copula mixed effect model for trivariate meta-analysis of diagnostic test accuracy studies accounting for disease prevalence.
A bivariate copula mixed model has been recently proposed to synthesize diagnostic test accuracy studies and it has been shown that it is superior to the standard generalized linear mixed model in this context. Here, we call trivariate vine copulas to extend the bivariate meta-analysis of diagnostic test accuracy studies by accounting for disease prevalence. Our vine copula mixed model includes the trivariate generalized linear mixed model as a special case and can also operate on the original scale of sensitivity, specificity, and disease prevalence. Our general methodology is illustrated by re-analyzing the data of two published meta-analyses. Our study suggests that there can be an improvement on trivariate generalized linear mixed model in fit to data and makes the argument for moving to vine copula random effects models especially because of their richness, including reflection asymmetric tail dependence, and computational feasibility despite their three dimensionality.
School of Computing Sciences, University of East Anglia, Norwich, UK.
Aristidis K
AK
Nikoloulopoulos
D004813:Epidemiology; D006801:Humans; D016014:Linear Models; D015201:Meta-Analysis as Topic; D015233:Models, Statistical; D015999:Multivariate Analysis; D015995:Prevalence; D011933:Reagent Kits, Diagnostic / Q000592:standards* / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D011933:Reagent Kits, Diagnostic
Copula models; diagnostic tests; multivariate meta-analysis; random effects models; sensitivity/specificity/prevalence; vines