Do You Believe in ReincaRNAtion? Herpesviruses Reveal Connection between RNA Decay and Synthesis.
Many viruses degrade host mRNAs to reduce competition for proteins/ribosomes and promote viral gene expression. In this issue of Cell Host & Microbe, Abernathy et al. (2015) demonstrate that a herpesviral RNA endonuclease induces host transcriptional repression that is mediated through the decay factor Xrn1 and evaded by viral genes.
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Joseph
J
Russo
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: jeffrey.wilusz@colostate.edu.
Jeffrey
J
Wilusz
D005246:Feedback; D018142:Gammaherpesvirinae / Q000201:enzymology*; D054884:Host-Pathogen Interactions; D006801:Humans; D020871:RNA Stability; D012260:Ribonucleases / Q000378:metabolism*; D014158:Transcription, Genetic
D012260:Ribonucleases