Prognostic Factors of Cholangiocarcinoma After Surgical Resection: A Retrospective Study of 293 Patients.
BACKGROUND
Cholangiocarcinoma is one of the most common malignancies in China. Surgical resection is the only treatment option; however, diagnosis at advanced stage precludes surgery. Comprehensive knowledge of prognostic markers is missing. Hence, the aim of this study was to determine clinicopathological indexes that would be indicative of prognosis in post-operative cases of cholangiocarcinoma.


METHODS
A retrospective analysis of 293 cases of cholangiocarcinoma patients attending the 301 Military Hospital in Beijing, China between January 2004 and December 2010 were included in the study. The patients had follow-up history until August 2012. Cox proportional hazards model analysis was performed to identify indexes of prognosis. All indicators were analyzed by univariate and multivariate analysis.


RESULTS
The median follow-up time was 55.90 months, with recurrence and metastasis in 162 cases (55.3%) and death in 223 cases (76.1%). The 1-year, 3-year, and 5-year survival rates were 71.7%, 38.2%, and 10.6%, respectively. The independent risk factors of overall survival were degree of tumor differentiation, TNM stage, surgical margin, intraoperative blood transfusion, tumor location, alkaline phosphatase levels in blood, and relapse.


CONCLUSIONS
Good prognosis in cholangiocarcinoma patients is indicated by highly differentiated tumor, early stages of TNM staging, no resection margin invaded, no intraoperative blood transfusion, intrahepatic tumor, normal alkaline phosphatase levels, and no relapse.
Department of Oncology, General Hospital of Air Force, Beijing, China (mainland).
Zhi-yuan
ZY
Mao
Department of Oncology, General Hospital of Chinese PLA, Beijing, China (mainland).
Xiao-chuan
XC
Guo
Department of Oncology, General Hospital of Chinese PLA, Beijing, China (mainland).
Dan
D
Su
Department of Oncology, General Hospital of Chinese PLA, Beijing, China (mainland).
Li-jie
LJ
Wang
Department of Oncology, General Hospital of Chinese PLA, Beijing, China (mainland).
Ting-ting
TT
Zhang
Department of Oncology, General Hospital of Chinese PLA, Beijing, China (mainland).
Li
L
Bai
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D002681:China / Q000453:epidemiology; D018281:Cholangiocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate