Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice.
As nanotheranostics, Congo red/Rutin-MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H2O2 response, and prevent oxidative stress.
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.|Institute of Materials Science and Engineering, Ocean University of China, Qingdao, 266100, P. R. China.
Bingbing
B
Hu
Beijing Center for Physical and Chemical Analysis, Beijing, 100084, P. R. China.
Fengying
F
Dai
Department of Radioloy, Beijing Anzhen Hospital, Capital University, Beijing, 100029, P. R. China.
Zhanming
Z
Fan
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Guanghui
G
Ma
Institute of Materials Science and Engineering, Ocean University of China, Qingdao, 266100, P. R. China.
Qunwei
Q
Tang
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Xin
X
Zhang
D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D003224:Congo Red / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008822:Mice, Transgenic; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D058225:Plaque, Amyloid / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D053764:Presenilin-1 / Q000235:genetics / Q000378:metabolism; D012431:Rutin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000068936:Theranostic Nanomedicine / Q000379:methods*
C545487:APP protein, human; D016564:Amyloid beta-Protein Precursor; D003287:Contrast Media; D004337:Drug Carriers; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D018696:Neuroprotective Agents; C508853:PSEN1 protein, human; D053764:Presenilin-1; C000499:ferric oxide; D003224:Congo Red; D012431:Rutin; D006861:Hydrogen Peroxide
Alzheimer's disease; H2O2-responsive; magnetic resonance imaging; nanotheranostics; therapy