Azaphilone and Diphenyl Ether Derivatives from a Gorgonian-Derived Strain of the Fungus Penicillium pinophilum.
Three new azaphilone derivatives, pinophilins D-F (1-3), and one new diphenyl ether derivative, hydroxypenicillide (10), together with nine known compounds (4-9, 11-13), were isolated from the gorgonian-derived fungus Penicillium pinophilum XS-20090E18. Their structures including absolute configurations were determined by spectroscopic data, chemical conversions, the ECD exciton chirality method, and ECD calculations. Compounds 10-13 exhibited inhibitory activity against the larval settlement of the barnacle Balanus amphitrite at nontoxic concentrations. Compounds 10 and 11 showed cytotoxicity against Hep-2, RD, and HeLa cell lines.
Dong-Lin
DL
Zhao
Chang-Lun
CL
Shao
College of Science, Northwest A&F University , Yangling 712100, People's Republic of China.
Qiang
Q
Zhang
Kai-Ling
KL
Wang
Fei-Fei
FF
Guan
Ting
T
Shi
Chang-Yun
CY
Wang
D000818:Animals; D037421:Anthozoa / Q000382:microbiology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010407:Penicillium / Q000737:chemistry*; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification*; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification*
D001578:Benzopyrans; D010647:Phenyl Ethers; D010860:Pigments, Biological; C494154:azaphilone