[C-TYPE NATRIURETIC PEP- TIDE: WHAT, WHERE AND WHAT FOR IS THIS?].
The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP)--are summarized in the review. Despite its name, this peptide does not stimulate sodium excretion but shares the prominent vasodilating and antyproliferating effects in different organs and tissues. The special emphasis is attended to CNP functions in central nervous system. The information about the peptide molecular biology, including intracellular processing, blood peptide concentration, specific receptors structure, and signaling pathways in target cells is presented.
I M
IM
Korostyshevskaya
V F
VF
Maksimov
N S
NS
Rudenko
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D051379:Mice; D020098:Natriuretic Peptide, C-Type / Q000097:blood / Q000737:chemistry / Q000235:genetics*; D051381:Rats; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D012964:Sodium / Q000378:metabolism*; D014664:Vasodilation / Q000502:physiology*
D020098:Natriuretic Peptide, C-Type; D012964:Sodium; D017461:Receptors, Atrial Natriuretic Factor; C091715:atrial natriuretic factor receptor A