The correlation of resistance exercise-induced myostatin with insulin resistance and plasma cytokines in healthy young men.
OBJECTIVE
This study was designed to examine the correlation of resistance exercise (RE)-induced myostatin (MSTN) with insulin resistance and plasma cytokines in healthy young men.


METHODS
Twenty-four healthy men were randomly divided into RE (n = 12) and control (n = 12) group. After a session of familiarization, one repetition maximum (1-RM) was calculated. Circuit RE program involved 3 sets of 15 repetitions at 55 % of 1-RM. Blood samples were collected before and 24 h after the exercise. Paired t test, independent t test, and Pearson's correlation were used for analyzing data.


RESULTS
A significant decrease in plasma level of MSTN, glucose, insulin, interleukin-6 (IL-6), and homeostasis model assessment of insulin resistance (HOMA-IR) and a significant increase in plasma interleukin-10 (IL-10) were found in RE group 24 h post-exercise versus pre-exercise (p < 0.05). Furthermore, except plasma IL-10, a significant decrease in metabolic variables was found in RE group versus control group (p < 0.05). A significantly positive correlation of plasma MSTN with HOMA-IR and plasma IL-6 and a significantly negative correlation of plasma MSTN with plasma IL-10 were found in RE group versus control group (p < 0.05).


CONCLUSIONS
It seems that a circuit RE bout by reducing HOMA-IR and changing plasma cytokines (decreased IL-6 and increased IL-10) can decrease plasma level of MSTN in healthy young men. In other word, the beneficial effect of acute RE may be reflected by changes in MSTN in healthy young individuals.
School of Physical Education and Sport Sciences, Shahid Beheshti University, Tehran, Iran. kazemi.fahimeh@yahoo.de.
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Kazemi
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D007333:Insulin Resistance; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D055435:Myostatin / Q000378:metabolism*; D011379:Prognosis; D055070:Resistance Training; D055815:Young Adult
D015415:Biomarkers; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; C525911:MSTN protein, human; D055435:Myostatin; D016753:Interleukin-10
Circuit resistance exercise; Insulin resistance; Interleukin-10; Interleukin-6; Myostatin