Efficacy and safety of tigecycline for the treatment of severe infectious diseases: an updated meta-analysis of RCTs.
OBJECTIVE
To assess the efficacy and safety of tigecycline in comparison with other antimicrobial treatments for infectious diseases.


METHODS
Databases of PubMed, Embase and the Cochrane Library were searched through Feb. 2015. The reference lists of the initially identified articles and systemic review articles were manually searched. Randomized controlled trials assessing tigecycline and other antibiotics for infectious diseases in adult patients were included.


RESULTS
Fifteen RCTs including 7689 cases were identified. We found that tigecycline was not as effective as the comparator agents for clinical treatment success (for the clinically evaluable population, odds ratio [OR] = 0.83, 95% confidence interval [CI] = (0.73, 0.96), P=0.01; for the clinically modified intent-to-treat (mITT) population, OR = 0.81, 95% CI = (0.72, 0.92), P=0.001). There was no significant difference in microbiological treatment success with lower eradication rate in tigecycline versus comparators (for the microbiologically evaluable population, OR = 0.94, 95% CI = (0.77, 1.16), P=0.56; for the microbiological mITT populations, OR = 0.91, 95% CI = (0.74, 1.11), P=0.35). Adverse events and all-cause mortality were more common in the tigecycline group.


CONCLUSIONS
Tigecycline is not as effective as other antibiotics with relatively more frequency of adverse events and higher mortality rate.
Department of Critical Care Medicine and Emergency, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China; Shantou University Medical College, Shantou, Guangdong, People's Republic of China. Electronic address: shenfengcai1111@126.com.
Fengcai
F
Shen
Department of Critical Care Medicine and Emergency, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China. Electronic address: hanqp@163.com.
Qianpeng
Q
Han
Department of Critical Care Medicine and Emergency, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China. Electronic address: xdaspiwn@163.com.
Di
D
Xie
Department of Critical Care Medicine and Emergency, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China. Electronic address: wellfm@163.com.
Ming
M
Fang
Department of Critical Care Medicine and Emergency, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China. Electronic address: zenghongke@vip.163.com.
Hongke
H
Zeng
Department of Critical Care Medicine and Emergency, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China. Electronic address: yiyudeng666@163.com.
Yiyu
Y
Deng
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000188:drug therapy; D006801:Humans; D007239:Infections / Q000188:drug therapy; D008911:Minocycline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
Community-acquired pneumonia; Complicated intra-abdominal infections; Complicated skin and skin-structure infections; Infectious diseases; Tigecycline