Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology.
Over the past decade, alternative splicing has been progressively recognized as a major mechanism regulating gene expression patterns in different tissues and disease states through the generation of multiple mRNAs from the same gene transcript. This process requires the joining of selected exons or usage of different pairs of splice sites and is regulated by gene-specific combinations of RNA-binding proteins. One archetypical splicing regulator is SRSF1, for which we review the molecular mechanisms and posttranscriptional modifications involved in its life cycle. These include alternative splicing of SRSF1 itself, regulatory protein phosphorylation events, and the role of nuclear versus cytoplasmic SRSF1 localization. In addition, we resume current knowledge on deregulated SRSF1 expression in tumors and describe SRSF1-regulated alternative transcripts with functional consequences for cancer cell biology at different stages of tumor development.
Department of Human Genetics, National Health Institute Dr. Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal ; Biosystems and Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal.
Vânia
V
Gonçalves
Department of Human Genetics, National Health Institute Dr. Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal ; Biosystems and Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal.
Peter
P
Jordan
D017398:Alternative Splicing / Q000235:genetics*; D002467:Cell Nucleus / Q000235:genetics; D003593:Cytoplasm / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D034622:RNA Interference / Q000502:physiology*; D000068103:Serine-Arginine Splicing Factors / Q000235:genetics*
C000595779:SRSF1 protein, human; D000068103:Serine-Arginine Splicing Factors